locus-tag	class	description
CXR04_RS00095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR04_RS00130	COG0604	alcohol dehydrogenase
CXR04_RS00130	COG3321	synthase
CXR04_RS00130	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS00225	COG2172	sigma factor antagonist activity
CXR04_RS00230	COG2172	sigma factor antagonist activity
CXR04_RS00235	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR04_RS00240	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR04_RS00310	COG1595	DNA-templated transcription, initiation
CXR04_RS00325	COG3119	arylsulfatase activity
CXR04_RS00335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXR04_RS00345	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS00350	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS00355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS00360	COG0601	transmembrane transport
CXR04_RS00365	COG0747	negative chemotaxis
CXR04_RS00375	COG1609	Transcriptional regulator
CXR04_RS00400	COG2066	Belongs to the glutaminase family
CXR04_RS00425	COG1335	isochorismatase
CXR04_RS00445	COG2409	Drug exporters of the RND superfamily
CXR04_RS00500	COG0583	DNA-binding transcription factor activity
CXR04_RS00525	COG4977	sequence-specific DNA binding
CXR04_RS00580	COG2814	Major facilitator Superfamily
CXR04_RS00585	COG1733	regulation of RNA biosynthetic process
CXR04_RS00590	COG3250	beta-galactosidase activity
CXR04_RS00605	COG2207	Transcriptional regulator
CXR04_RS00610	COG2223	nitrite transmembrane transporter activity
CXR04_RS00630	COG0477	Major facilitator Superfamily
CXR04_RS00645	COG0587	DNA-directed DNA polymerase activity
CXR04_RS00675	COG1309	transcriptional regulator
CXR04_RS00685	COG2084	Dehydrogenase
CXR04_RS00695	COG0402	S-adenosylhomocysteine deaminase activity
CXR04_RS00725	COG1063	alcohol dehydrogenase
CXR04_RS00740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXR04_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS00765	COG4948	Mandelate Racemase Muconate Lactonizing
CXR04_RS00770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXR04_RS00775	COG1414	Transcriptional regulator
CXR04_RS00785	COG0673	inositol 2-dehydrogenase activity
CXR04_RS00795	COG1175	transmembrane transport
CXR04_RS00800	COG0395	ABC-type sugar transport system, permease component
CXR04_RS00855	COG2186	Transcriptional regulator
CXR04_RS00875	COG1216	Glycosyl transferase, family 2
CXR04_RS00880	COG1228	amidohydrolase
CXR04_RS00885	COG1522	sequence-specific DNA binding
CXR04_RS00895	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS00955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXR04_RS00960	COG0140	phosphoribosyl-ATP diphosphatase activity
CXR04_RS00965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXR04_RS00975	COG3201	nicotinamide mononucleotide transporter
CXR04_RS01000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXR04_RS01025	COG2838	Isocitrate dehydrogenase
CXR04_RS01030	COG2301	Belongs to the HpcH HpaI aldolase family
CXR04_RS01035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR04_RS01040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR04_RS01085	COG1921	L-seryl-tRNASec selenium transferase activity
CXR04_RS01095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR04_RS01125	COG2207	Transcriptional regulator
CXR04_RS01125	COG0662	Cupin 2, conserved barrel domain protein
CXR04_RS01150	COG0435	Glutathione S-transferase
CXR04_RS01155	COG0456	acetyltransferase
CXR04_RS01160	COG2801	Transposase and inactivated derivatives
CXR04_RS01160	COG3415	Transposase
CXR04_RS01180	COG1695	Transcriptional regulator
CXR04_RS01195	COG2197	response regulator
CXR04_RS01200	COG4585	Histidine kinase
CXR04_RS01210	COG3547	Transposase (IS116 IS110 IS902 family)
CXR04_RS01285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXR04_RS01315	COG0386	Belongs to the glutathione peroxidase family
CXR04_RS01335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXR04_RS01395	COG0640	Transcriptional regulator
CXR04_RS01400	COG0346	lactoylglutathione lyase activity
CXR04_RS01420	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS01430	COG1024	Enoyl-CoA hydratase
CXR04_RS01435	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS01470	COG2205	protein histidine kinase activity
CXR04_RS01475	COG0745	RESPONSE REGULATOR receiver
CXR04_RS01510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXR04_RS01515	COG2124	cytochrome p450
CXR04_RS01620	COG0805	protein transport
CXR04_RS01625	COG0640	Transcriptional regulator
CXR04_RS01645	COG3119	arylsulfatase activity
CXR04_RS01685	COG0519	Catalyzes the synthesis of GMP from XMP
CXR04_RS01710	COG2169	Transcriptional regulator
CXR04_RS01710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXR04_RS01715	COG1595	DNA-templated transcription, initiation
CXR04_RS01720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXR04_RS01740	COG0534	Mate efflux family protein
CXR04_RS01745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXR04_RS01750	COG0019	diaminopimelate decarboxylase activity
CXR04_RS01765	COG4166	transmembrane transport
CXR04_RS01770	COG0601	transmembrane transport
CXR04_RS01775	COG4171	peptide transport system, permease
CXR04_RS01780	COG4172	Belongs to the ABC transporter superfamily
CXR04_RS01790	COG0671	phosphoesterase, PA-phosphatase related
CXR04_RS01855	COG1793	dna ligase
CXR04_RS01865	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS01870	COG0202	RNA polymerase activity
CXR04_RS01885	COG0515	serine threonine protein kinase
CXR04_RS01895	COG1024	Enoyl-CoA hydratase
CXR04_RS01915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CXR04_RS01920	COG0405	Gamma-glutamyltransferase
CXR04_RS01930	COG0783	Belongs to the Dps family
CXR04_RS01935	COG0739	heme binding
CXR04_RS01935	COG0741	lytic transglycosylase activity
CXR04_RS01935	COG1196	nuclear chromosome segregation
CXR04_RS01940	COG1609	Transcriptional regulator
CXR04_RS01945	COG1653	transport
CXR04_RS01960	COG3119	arylsulfatase activity
CXR04_RS01970	COG3959	Transketolase, thiamine diphosphate binding domain
CXR04_RS01975	COG3958	Transketolase
CXR04_RS01995	COG3540	Alkaline phosphatase
CXR04_RS02040	COG2365	Tyrosine phosphatase family
CXR04_RS02050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXR04_RS02065	COG1657	PFAM Prenyltransferase squalene oxidase
CXR04_RS02075	COG1233	COG1233 Phytoene dehydrogenase and related
CXR04_RS02085	COG1562	ergosterol biosynthetic process
CXR04_RS02095	COG2409	Drug exporters of the RND superfamily
CXR04_RS02100	COG1134	teichoic acid transport
CXR04_RS02100	COG1388	LysM domain
CXR04_RS02120	COG0371	Dehydrogenase
CXR04_RS02145	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CXR04_RS02155	COG0488	(ABC) transporter
CXR04_RS02170	COG2183	response to ionizing radiation
CXR04_RS02195	COG0789	Transcriptional regulator
CXR04_RS02205	COG1024	Enoyl-CoA hydratase
CXR04_RS02205	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR04_RS02210	COG0183	Belongs to the thiolase family
CXR04_RS02215	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS02220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR04_RS02225	COG3268	Saccharopine dehydrogenase
CXR04_RS02235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CXR04_RS02275	COG1793	dna ligase
CXR04_RS02295	COG2205	protein histidine kinase activity
CXR04_RS02300	COG0745	RESPONSE REGULATOR receiver
CXR04_RS02305	COG0577	efflux transmembrane transporter activity
CXR04_RS02310	COG1136	(ABC) transporter
CXR04_RS02310	COG0577	efflux transmembrane transporter activity
CXR04_RS02330	COG2124	cytochrome p450
CXR04_RS02335	COG2124	cytochrome p450
CXR04_RS02340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR04_RS02365	COG1132	(ABC) transporter
CXR04_RS02375	COG2205	protein histidine kinase activity
CXR04_RS02380	COG0745	RESPONSE REGULATOR receiver
CXR04_RS02390	COG1024	Enoyl-CoA hydratase
CXR04_RS02395	COG1024	Enoyl-CoA hydratase
CXR04_RS02400	COG3424	synthase
CXR04_RS02440	COG1595	DNA-templated transcription, initiation
CXR04_RS02450	COG1132	(ABC) transporter
CXR04_RS02460	COG3275	phosphorelay sensor kinase activity
CXR04_RS02475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR04_RS02485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR04_RS02490	COG0583	DNA-binding transcription factor activity
CXR04_RS02505	COG3119	arylsulfatase activity
CXR04_RS02510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXR04_RS02515	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR04_RS02550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXR04_RS02565	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR04_RS02570	COG0395	ABC-type sugar transport system, permease component
CXR04_RS02575	COG1175	transmembrane transport
CXR04_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS02605	COG3119	arylsulfatase activity
CXR04_RS02610	COG0745	RESPONSE REGULATOR receiver
CXR04_RS02700	COG0667	Aldo Keto reductase
CXR04_RS02705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR04_RS02710	COG0584	glycerophosphoryl diester phosphodiesterase
CXR04_RS02720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR04_RS02790	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS02795	COG1309	transcriptional regulator
CXR04_RS02800	COG1132	(ABC) transporter
CXR04_RS02805	COG1404	Belongs to the peptidase S8 family
CXR04_RS02810	COG2197	response regulator
CXR04_RS02815	COG1404	Belongs to the peptidase S8 family
CXR04_RS02830	COG5006	permease, DMT superfamily
CXR04_RS02835	COG1446	asparaginase
CXR04_RS02850	COG2815	serine threonine protein kinase
CXR04_RS02850	COG0515	serine threonine protein kinase
CXR04_RS02865	COG1846	Transcriptional regulator
CXR04_RS02865	COG1940	carbohydrate kinase activity
CXR04_RS02870	COG0395	ABC-type sugar transport system, permease component
CXR04_RS02875	COG1175	transmembrane transport
CXR04_RS02885	COG1063	alcohol dehydrogenase
CXR04_RS02890	COG1082	Xylose isomerase domain protein TIM barrel
CXR04_RS02895	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CXR04_RS02905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXR04_RS02905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXR04_RS02910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR04_RS02915	COG1414	Transcriptional regulator
CXR04_RS02920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR04_RS02935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS02950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXR04_RS02980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR04_RS03020	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR04_RS03045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS03105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR04_RS03110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR04_RS03110	COG3321	synthase
CXR04_RS03110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR04_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS03110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR04_RS03145	COG0019	diaminopimelate decarboxylase activity
CXR04_RS03160	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR04_RS03185	COG3903	Transcriptional regulator
CXR04_RS03185	COG3629	intracellular signal transduction
CXR04_RS03190	COG0589	response to stress
CXR04_RS03200	COG1129	ABC transporter
CXR04_RS03230	COG1132	(ABC) transporter
CXR04_RS03240	COG0655	NAD(P)H dehydrogenase (quinone) activity
CXR04_RS03285	COG0277	FAD linked oxidase domain protein
CXR04_RS03295	COG1609	Transcriptional regulator
CXR04_RS03315	COG0395	ABC-type sugar transport system, permease component
CXR04_RS03340	COG0395	ABC-type sugar transport system, permease component
CXR04_RS03345	COG1175	transmembrane transport
CXR04_RS03380	COG2197	response regulator
CXR04_RS03400	COG0488	(ABC) transporter
CXR04_RS03445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CXR04_RS03450	COG0477	Major facilitator Superfamily
CXR04_RS03460	COG0697	spore germination
CXR04_RS03475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CXR04_RS03530	COG1940	carbohydrate kinase activity
CXR04_RS03535	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CXR04_RS03655	COG0477	Major facilitator Superfamily
CXR04_RS03660	COG0248	Ppx GppA phosphatase
CXR04_RS03745	COG0477	Major facilitator Superfamily
CXR04_RS03755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR04_RS03780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR04_RS03805	COG0515	serine threonine protein kinase
CXR04_RS03805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS03810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS03810	COG0515	serine threonine protein kinase
CXR04_RS03830	COG2801	Transposase and inactivated derivatives
CXR04_RS03830	COG3415	Transposase
CXR04_RS03850	COG3209	COG3209 Rhs family protein
CXR04_RS03860	COG2409	Drug exporters of the RND superfamily
CXR04_RS03865	COG3851	Histidine kinase
CXR04_RS03870	COG2197	response regulator
CXR04_RS03890	COG5183	chlorophyll binding
CXR04_RS03890	COG2133	pyrroloquinoline quinone binding
CXR04_RS03900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR04_RS03905	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CXR04_RS03910	COG3971	2-oxopent-4-enoate hydratase activity
CXR04_RS03925	COG1335	isochorismatase
CXR04_RS03955	COG1116	anion transmembrane transporter activity
CXR04_RS03960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS03965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS03985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXR04_RS03985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXR04_RS04005	COG1228	amidohydrolase
CXR04_RS04030	COG1007	ATP synthesis coupled electron transport
CXR04_RS04040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXR04_RS04055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CXR04_RS04065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS04080	COG1473	amidohydrolase
CXR04_RS04150	COG2132	Multicopper oxidase
CXR04_RS04160	COG0745	RESPONSE REGULATOR receiver
CXR04_RS04170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXR04_RS04180	COG0154	amidase activity
CXR04_RS04190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CXR04_RS04205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CXR04_RS04210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR04_RS04220	COG2409	Drug exporters of the RND superfamily
CXR04_RS04225	COG1595	DNA-templated transcription, initiation
CXR04_RS04240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR04_RS04320	COG3629	intracellular signal transduction
CXR04_RS04360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR04_RS04395	COG0589	response to stress
CXR04_RS04420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CXR04_RS04455	COG2815	serine threonine protein kinase
CXR04_RS04455	COG0515	serine threonine protein kinase
CXR04_RS04465	COG0443	Heat shock 70 kDa protein
CXR04_RS04485	COG0515	serine threonine protein kinase
CXR04_RS04490	COG0542	response to heat
CXR04_RS04505	COG0443	Heat shock 70 kDa protein
CXR04_RS04525	COG3437	response regulator, receiver
CXR04_RS04545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR04_RS04655	COG3387	PFAM Glycoside hydrolase 15-related
CXR04_RS04725	COG1940	carbohydrate kinase activity
CXR04_RS04735	COG1175	transmembrane transport
CXR04_RS04740	COG0395	ABC-type sugar transport system, permease component
CXR04_RS04755	COG1609	Transcriptional regulator
CXR04_RS04760	COG1554	hydrolase, family 65, central catalytic
CXR04_RS04775	COG1653	transport
CXR04_RS04805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR04_RS04845	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CXR04_RS04870	COG0673	inositol 2-dehydrogenase activity
CXR04_RS04875	COG4213	ABC transporter substrate-binding protein
CXR04_RS04880	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS04885	COG1129	ABC transporter
CXR04_RS04890	COG1940	carbohydrate kinase activity
CXR04_RS04895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXR04_RS04930	COG0656	L-ascorbic acid biosynthetic process
CXR04_RS04935	COG2365	Tyrosine phosphatase family
CXR04_RS04940	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXR04_RS04950	COG3119	arylsulfatase activity
CXR04_RS04955	COG3119	arylsulfatase activity
CXR04_RS05000	COG2226	methyltransferase
CXR04_RS05025	COG0076	glutamate decarboxylase activity
CXR04_RS05040	COG1619	proteins homologs of microcin C7 resistance protein MccF
CXR04_RS05045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR04_RS05050	COG2362	D-Aminopeptidase
CXR04_RS05085	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CXR04_RS05085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CXR04_RS05090	COG2301	Belongs to the HpcH HpaI aldolase family
CXR04_RS05100	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS05105	COG0688	phosphatidylethanolamine metabolic process
CXR04_RS05120	COG0583	DNA-binding transcription factor activity
CXR04_RS05125	COG1929	Belongs to the glycerate kinase type-1 family
CXR04_RS05130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXR04_RS05145	COG0483	inositol monophosphate 1-phosphatase activity
CXR04_RS05155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXR04_RS05165	COG1953	Uracil, thiamine, allantoin
CXR04_RS05175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR04_RS05180	COG0515	serine threonine protein kinase
CXR04_RS05195	COG1132	(ABC) transporter
CXR04_RS05200	COG2197	response regulator
CXR04_RS05205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXR04_RS05225	COG3415	Transposase
CXR04_RS05225	COG2801	Transposase and inactivated derivatives
CXR04_RS05260	COG1940	carbohydrate kinase activity
CXR04_RS05280	COG2188	Transcriptional regulator
CXR04_RS05295	COG0800	Aldolase
CXR04_RS05305	COG3291	Pkd domain containing protein
CXR04_RS05305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CXR04_RS05310	COG4266	Belongs to the allantoicase family
CXR04_RS05315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR04_RS05320	COG1414	Transcriptional regulator
CXR04_RS05330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXR04_RS05335	COG4821	SIS domain
CXR04_RS05350	COG2351	hydroxyisourate hydrolase activity
CXR04_RS05370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR04_RS05375	COG2197	response regulator
CXR04_RS05380	COG2197	response regulator
CXR04_RS05400	COG2205	protein histidine kinase activity
CXR04_RS05410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CXR04_RS05420	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXR04_RS05425	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CXR04_RS05430	COG3622	Belongs to the hyi family
CXR04_RS05435	COG2084	Dehydrogenase
CXR04_RS05440	COG3960	tartronate-semialdehyde synthase activity
CXR04_RS05455	COG2197	response regulator
CXR04_RS05460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR04_RS05470	COG0318	PFAM AMP-dependent synthetase and ligase
CXR04_RS05475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR04_RS05480	COG2197	response regulator
CXR04_RS05490	COG2264	protein methyltransferase activity
CXR04_RS05510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXR04_RS05515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CXR04_RS05515	COG3608	succinylglutamate desuccinylase aspartoacylase
CXR04_RS05520	COG2252	PERMEase
CXR04_RS05525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXR04_RS05540	COG3835	regulator
CXR04_RS05555	COG1522	sequence-specific DNA binding
CXR04_RS05575	COG0673	inositol 2-dehydrogenase activity
CXR04_RS05590	COG3458	cephalosporin-C deacetylase activity
CXR04_RS05595	COG1802	Transcriptional regulator
CXR04_RS05625	COG1309	transcriptional regulator
CXR04_RS05630	COG1162	GTPase activity
CXR04_RS05635	COG1796	DNA polymerase
CXR04_RS05635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CXR04_RS05645	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS05650	COG3284	Transcriptional regulator
CXR04_RS05670	COG0175	sulfate reduction
CXR04_RS05690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS05695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXR04_RS05700	COG1116	anion transmembrane transporter activity
CXR04_RS05710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR04_RS05720	COG1116	anion transmembrane transporter activity
CXR04_RS05725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS05730	COG2409	Drug exporters of the RND superfamily
CXR04_RS05770	COG1132	(ABC) transporter
CXR04_RS05785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXR04_RS05815	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
CXR04_RS05820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR04_RS05850	COG1349	DNA-binding transcription factor activity
CXR04_RS05855	COG4213	ABC transporter substrate-binding protein
CXR04_RS05865	COG4214	carbohydrate transport
CXR04_RS05885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXR04_RS05895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXR04_RS05900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXR04_RS05940	COG1280	lysine exporter protein (LysE YggA)
CXR04_RS05945	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXR04_RS05955	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CXR04_RS05960	COG3253	May function as heme-dependent peroxidase
CXR04_RS05975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXR04_RS05995	COG0183	Belongs to the thiolase family
CXR04_RS06000	COG1024	Enoyl-CoA hydratase
CXR04_RS06000	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR04_RS06010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXR04_RS06015	COG4214	carbohydrate transport
CXR04_RS06025	COG4213	ABC transporter substrate-binding protein
CXR04_RS06030	COG1940	carbohydrate kinase activity
CXR04_RS06035	COG0395	ABC-type sugar transport system, permease component
CXR04_RS06040	COG1175	transmembrane transport
CXR04_RS06045	COG1653	transport
CXR04_RS06065	COG3209	COG3209 Rhs family protein
CXR04_RS06070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXR04_RS06110	COG2267	carboxylic ester hydrolase activity
CXR04_RS06125	COG1024	Enoyl-CoA hydratase
CXR04_RS06130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXR04_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS06145	COG2235	arginine
CXR04_RS06150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXR04_RS06160	COG2040	homocysteine
CXR04_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS06180	COG1799	cell septum assembly
CXR04_RS06185	COG3540	Alkaline phosphatase
CXR04_RS06205	COG0739	heme binding
CXR04_RS06205	COG0741	lytic transglycosylase activity
CXR04_RS06205	COG1196	nuclear chromosome segregation
CXR04_RS06250	COG3119	arylsulfatase activity
CXR04_RS06290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CXR04_RS06340	COG2132	Multicopper oxidase
CXR04_RS06345	COG2409	Drug exporters of the RND superfamily
CXR04_RS06375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR04_RS06390	COG3938	Belongs to the proline racemase family
CXR04_RS06400	COG0514	ATP-dependent DNA helicase (RecQ)
CXR04_RS06420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR04_RS06425	COG1070	Carbohydrate kinase
CXR04_RS06430	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS06435	COG1129	ABC transporter
CXR04_RS06450	COG2188	Transcriptional regulator
CXR04_RS06460	COG1879	ABC-type sugar transport system periplasmic component
CXR04_RS06465	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS06470	COG1129	ABC transporter
CXR04_RS06490	COG1609	Transcriptional regulator
CXR04_RS06500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS06510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR04_RS06545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR04_RS06555	COG4221	oxidoreductase activity
CXR04_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS06565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR04_RS06570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CXR04_RS06590	COG0527	aspartate kinase activity
CXR04_RS06595	COG4585	Histidine kinase
CXR04_RS06600	COG2197	response regulator
CXR04_RS06620	COG2409	Drug exporters of the RND superfamily
CXR04_RS06630	COG2814	Major facilitator Superfamily
CXR04_RS06640	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS06650	COG0601	transmembrane transport
CXR04_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS06660	COG4166	transmembrane transport
CXR04_RS06665	COG0006	proline dipeptidase activity
CXR04_RS06670	COG1802	Transcriptional regulator
CXR04_RS06675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR04_RS06680	COG3291	Pkd domain containing protein
CXR04_RS06685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR04_RS06685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR04_RS06715	COG2197	response regulator
CXR04_RS06720	COG4585	Histidine kinase
CXR04_RS06730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR04_RS06745	COG3395	kinase activity
CXR04_RS06750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXR04_RS06755	COG2188	Transcriptional regulator
CXR04_RS06760	COG0174	glutamine synthetase
CXR04_RS06785	COG1609	Transcriptional regulator
CXR04_RS06795	COG0395	ABC-type sugar transport system, permease component
CXR04_RS06805	COG1653	transport
CXR04_RS06850	COG2205	protein histidine kinase activity
CXR04_RS06855	COG0745	RESPONSE REGULATOR receiver
CXR04_RS06870	COG1136	(ABC) transporter
CXR04_RS06870	COG0577	efflux transmembrane transporter activity
CXR04_RS06875	COG0577	efflux transmembrane transporter activity
CXR04_RS06875	COG1136	(ABC) transporter
CXR04_RS06880	COG2755	lipolytic protein G-D-S-L family
CXR04_RS06930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR04_RS06950	COG2356	endonuclease I
CXR04_RS06985	COG0402	S-adenosylhomocysteine deaminase activity
CXR04_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS07045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR04_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS07080	COG0753	catalase activity
CXR04_RS07090	COG1418	mRNA catabolic process
CXR04_RS07165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXR04_RS07170	COG0569	domain protein
CXR04_RS07200	COG1136	(ABC) transporter
CXR04_RS07205	COG0577	efflux transmembrane transporter activity
CXR04_RS07205	COG1136	(ABC) transporter
CXR04_RS07245	COG0756	dUTP diphosphatase activity
CXR04_RS07270	COG2205	protein histidine kinase activity
CXR04_RS07275	COG0745	RESPONSE REGULATOR receiver
CXR04_RS07285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXR04_RS07335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXR04_RS07340	COG1802	Transcriptional regulator
CXR04_RS07350	COG0612	Peptidase, M16
CXR04_RS07355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR04_RS07370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXR04_RS07375	COG3290	protein histidine kinase activity
CXR04_RS07395	COG1175	transmembrane transport
CXR04_RS07400	COG0395	ABC-type sugar transport system, permease component
CXR04_RS07405	COG0366	Alpha amylase catalytic
CXR04_RS07445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXR04_RS07450	COG2186	Transcriptional regulator
CXR04_RS07455	COG1129	ABC transporter
CXR04_RS07495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXR04_RS07500	COG1309	transcriptional regulator
CXR04_RS07530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR04_RS07535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXR04_RS07540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXR04_RS07550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CXR04_RS07555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CXR04_RS07590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXR04_RS07600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXR04_RS07605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXR04_RS07620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXR04_RS07630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXR04_RS07635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR04_RS07640	COG0765	amino acid transport
CXR04_RS07645	COG0765	amino acid transport
CXR04_RS07650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR04_RS07655	COG1126	abc transporter atp-binding protein
CXR04_RS07665	COG2205	protein histidine kinase activity
CXR04_RS07695	COG2207	Transcriptional regulator
CXR04_RS07695	COG1917	Cupin 2, conserved barrel domain protein
CXR04_RS07700	COG1201	RNA secondary structure unwinding
CXR04_RS07705	COG2197	response regulator
CXR04_RS07715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR04_RS07720	COG1396	sequence-specific DNA binding
CXR04_RS07725	COG1546	Belongs to the CinA family
CXR04_RS07725	COG1058	Belongs to the CinA family
CXR04_RS07735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXR04_RS07745	COG1674	ftsk spoiiie
CXR04_RS07760	COG2770	Histidine kinase
CXR04_RS07760	COG2208	phosphoserine phosphatase activity
CXR04_RS07780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CXR04_RS07785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR04_RS07805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXR04_RS07810	COG0612	Peptidase, M16
CXR04_RS07815	COG1185	polyribonucleotide nucleotidyltransferase activity
CXR04_RS07820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXR04_RS07825	COG1196	nuclear chromosome segregation
CXR04_RS07825	COG0741	lytic transglycosylase activity
CXR04_RS07825	COG0739	heme binding
CXR04_RS07830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS07840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS07840	COG0515	serine threonine protein kinase
CXR04_RS07850	COG0455	bacterial-type flagellum organization
CXR04_RS07855	COG0747	negative chemotaxis
CXR04_RS07860	COG0601	transmembrane transport
CXR04_RS07865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS07870	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS07875	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS07895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXR04_RS07900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXR04_RS07910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXR04_RS07925	COG0779	Required for maturation of 30S ribosomal subunits
CXR04_RS07945	COG0768	penicillin binding
CXR04_RS07950	COG0442	prolyl-tRNA aminoacylation
CXR04_RS07965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXR04_RS07970	COG0750	zinc metalloprotease
CXR04_RS07975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXR04_RS07985	COG0640	Transcriptional regulator
CXR04_RS07995	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS08005	COG2508	Transcriptional regulator
CXR04_RS08015	COG1595	DNA-templated transcription, initiation
CXR04_RS08045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CXR04_RS08055	COG0477	Major facilitator Superfamily
CXR04_RS08080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR04_RS08085	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXR04_RS08090	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXR04_RS08095	COG3842	ATPase activity
CXR04_RS08115	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS08120	COG1522	sequence-specific DNA binding
CXR04_RS08125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR04_RS08130	COG1136	(ABC) transporter
CXR04_RS08140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR04_RS08150	COG2205	protein histidine kinase activity
CXR04_RS08155	COG0745	RESPONSE REGULATOR receiver
CXR04_RS08170	COG0577	efflux transmembrane transporter activity
CXR04_RS08170	COG1136	(ABC) transporter
CXR04_RS08175	COG1136	(ABC) transporter
CXR04_RS08175	COG0577	efflux transmembrane transporter activity
CXR04_RS08180	COG3842	ATPase activity
CXR04_RS08195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXR04_RS08205	COG0575	Belongs to the CDS family
CXR04_RS08210	COG0233	cytoplasmic translational termination
CXR04_RS08215	COG0528	UMP kinase activity
CXR04_RS08220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXR04_RS08225	COG0052	Belongs to the universal ribosomal protein uS2 family
CXR04_RS08240	COG1191	sigma factor activity
CXR04_RS08255	COG0792	nuclease activity
CXR04_RS08270	COG0681	Belongs to the peptidase S26 family
CXR04_RS08280	COG0681	Belongs to the peptidase S26 family
CXR04_RS08285	COG0335	large ribosomal subunit rRNA binding
CXR04_RS08290	COG0336	Belongs to the RNA methyltransferase TrmD family
CXR04_RS08295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXR04_RS08300	COG1837	Belongs to the UPF0109 family
CXR04_RS08305	COG0228	four-way junction DNA binding
CXR04_RS08315	COG0442	prolyl-tRNA aminoacylation
CXR04_RS08325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CXR04_RS08355	COG1196	nuclear chromosome segregation
CXR04_RS08365	COG1254	Belongs to the acylphosphatase family
CXR04_RS08370	COG2340	Cysteine-rich secretory protein family
CXR04_RS08375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR04_RS08380	COG0571	ribonuclease III activity
CXR04_RS08385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXR04_RS08400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CXR04_RS08405	COG0742	ribosomal rna small subunit methyltransferase
CXR04_RS08415	COG0326	Molecular chaperone. Has ATPase activity
CXR04_RS08425	COG1461	Dihydroxyacetone kinase
CXR04_RS08430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXR04_RS08435	COG0351	phosphomethylpyrimidine kinase
CXR04_RS08455	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXR04_RS08460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXR04_RS08470	COG1920	GTP binding
CXR04_RS08480	COG0776	regulation of translation
CXR04_RS08490	COG0066	3-isopropylmalate dehydratase activity
CXR04_RS08495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXR04_RS08500	COG1414	Transcriptional regulator
CXR04_RS08530	COG2018	Roadblock/LC7 domain
CXR04_RS08555	COG2018	Roadblock/LC7 domain
CXR04_RS08570	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXR04_RS08575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXR04_RS08585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR04_RS08600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR04_RS08610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXR04_RS08615	COG0473	3-isopropylmalate dehydrogenase activity
CXR04_RS08630	COG0069	glutamate synthase activity
CXR04_RS08635	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS08640	COG0506	proline dehydrogenase activity
CXR04_RS08660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR04_RS08665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXR04_RS08670	COG0440	acetolactate synthase activity
CXR04_RS08690	COG0667	Aldo Keto reductase
CXR04_RS08695	COG2133	pyrroloquinoline quinone binding
CXR04_RS08700	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CXR04_RS08700	COG1672	PFAM Archaeal ATPase
CXR04_RS08705	COG2197	response regulator
CXR04_RS08715	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CXR04_RS08715	COG1672	PFAM Archaeal ATPase
CXR04_RS08725	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CXR04_RS08725	COG1672	PFAM Archaeal ATPase
CXR04_RS08735	COG2409	Drug exporters of the RND superfamily
CXR04_RS08740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXR04_RS08750	COG0154	amidase activity
CXR04_RS08755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXR04_RS08765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXR04_RS08775	COG4221	oxidoreductase activity
CXR04_RS08785	COG0482	sulfurtransferase activity
CXR04_RS08800	COG2860	membrane
CXR04_RS08805	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS08810	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS08820	COG0747	negative chemotaxis
CXR04_RS08825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS08850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXR04_RS08855	COG0509	glycine decarboxylation via glycine cleavage system
CXR04_RS08860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXR04_RS08865	COG1760	l-serine dehydratase
CXR04_RS08920	COG5640	endopeptidase activity
CXR04_RS08925	COG0583	DNA-binding transcription factor activity
CXR04_RS08945	COG1280	lysine exporter protein (LysE YggA)
CXR04_RS09000	COG1376	ErfK ybiS ycfS ynhG family protein
CXR04_RS09010	COG1132	(ABC) transporter
CXR04_RS09015	COG1132	(ABC) transporter
CXR04_RS09040	COG1309	transcriptional regulator
CXR04_RS09060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CXR04_RS09070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CXR04_RS09070	COG2755	lipolytic protein G-D-S-L family
CXR04_RS09095	COG1301	dicarboxylic acid transport
CXR04_RS09100	COG3290	protein histidine kinase activity
CXR04_RS09105	COG4565	transcriptional regulatory protein
CXR04_RS09115	COG1175	transmembrane transport
CXR04_RS09120	COG0395	ABC-type sugar transport system, permease component
CXR04_RS09140	COG0667	Aldo Keto reductase
CXR04_RS09145	COG0583	DNA-binding transcription factor activity
CXR04_RS09165	COG0205	6-phosphofructokinase activity
CXR04_RS09170	COG0857	belongs to the CobB CobQ family
CXR04_RS09170	COG0280	phosphate acetyltransferase
CXR04_RS09175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CXR04_RS09215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CXR04_RS09215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CXR04_RS09280	COG0183	Belongs to the thiolase family
CXR04_RS09320	COG2197	response regulator
CXR04_RS09325	COG4585	Histidine kinase
CXR04_RS09355	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR04_RS09370	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CXR04_RS09405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXR04_RS09410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXR04_RS09415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXR04_RS09420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXR04_RS09425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXR04_RS09430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXR04_RS09435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXR04_RS09455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR04_RS09465	COG2890	protein-(glutamine-N5) methyltransferase activity
CXR04_RS09470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXR04_RS09475	COG0254	rRNA binding
CXR04_RS09480	COG1316	TRANSCRIPTIONal
CXR04_RS09490	COG0083	homoserine kinase activity
CXR04_RS09495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CXR04_RS09500	COG0460	homoserine dehydrogenase
CXR04_RS09505	COG0019	diaminopimelate decarboxylase activity
CXR04_RS09510	COG0018	arginyl-trna synthetase
CXR04_RS09510	COG0018	arginyl-trna synthetase
CXR04_RS09515	COG0745	RESPONSE REGULATOR receiver
CXR04_RS09540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXR04_RS09595	COG3620	sequence-specific DNA binding
CXR04_RS09630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXR04_RS09640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR04_RS09740	COG4249	Peptidase C14 caspase catalytic subunit p20
CXR04_RS09740	COG2319	Wd-40 repeat
CXR04_RS09785	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXR04_RS09885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CXR04_RS09945	COG0714	Associated with various cellular activities
CXR04_RS10110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXR04_RS10115	COG1518	maintenance of DNA repeat elements
CXR04_RS10130	COG1857	crispr-associated protein
CXR04_RS10165	COG0789	Transcriptional regulator
CXR04_RS10180	COG1716	ATPase activity
CXR04_RS10180	COG0842	Transport permease protein
CXR04_RS10180	COG1131	(ABC) transporter
CXR04_RS10195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXR04_RS10200	COG2226	methyltransferase
CXR04_RS10205	COG3119	arylsulfatase activity
CXR04_RS10220	COG1309	transcriptional regulator
CXR04_RS10235	COG0181	hydroxymethylbilane synthase activity
CXR04_RS10240	COG0154	amidase activity
CXR04_RS10315	COG0583	DNA-binding transcription factor activity
CXR04_RS10340	COG0515	serine threonine protein kinase
CXR04_RS10340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS10365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXR04_RS10375	COG3424	synthase
CXR04_RS10380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXR04_RS10395	COG4106	trans-aconitate 2-methyltransferase activity
CXR04_RS10400	COG1595	DNA-templated transcription, initiation
CXR04_RS10410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXR04_RS10415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXR04_RS10425	COG0439	Biotin carboxylase
CXR04_RS10445	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CXR04_RS10475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR04_RS10520	COG3629	intracellular signal transduction
CXR04_RS10520	COG3903	Transcriptional regulator
CXR04_RS10525	COG2197	response regulator
CXR04_RS10530	COG4585	Histidine kinase
CXR04_RS10535	COG2409	Drug exporters of the RND superfamily
CXR04_RS10540	COG3467	pyridoxamine 5'-phosphate
CXR04_RS10555	COG3540	Alkaline phosphatase
CXR04_RS10565	COG2309	aminopeptidase activity
CXR04_RS10575	COG0129	dihydroxy-acid dehydratase activity
CXR04_RS10580	COG1063	alcohol dehydrogenase
CXR04_RS10595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR04_RS10600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR04_RS10605	COG4948	Mandelate Racemase Muconate Lactonizing
CXR04_RS10650	COG1595	DNA-templated transcription, initiation
CXR04_RS10655	COG0384	phenazine biosynthesis protein PhzF
CXR04_RS10660	COG0477	Major facilitator Superfamily
CXR04_RS10685	COG1733	regulation of RNA biosynthetic process
CXR04_RS10695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXR04_RS10695	COG0519	Catalyzes the synthesis of GMP from XMP
CXR04_RS10705	COG0768	penicillin binding
CXR04_RS10725	COG0791	NLP P60 protein
CXR04_RS10750	COG1846	Transcriptional regulator
CXR04_RS10755	COG1846	Transcriptional regulator
CXR04_RS10790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXR04_RS10800	COG0745	RESPONSE REGULATOR receiver
CXR04_RS10805	COG2205	protein histidine kinase activity
CXR04_RS10810	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR04_RS10810	COG0567	Dehydrogenase, E1 component
CXR04_RS10875	COG0604	alcohol dehydrogenase
CXR04_RS10880	COG1126	abc transporter atp-binding protein
CXR04_RS10885	COG0765	amino acid transport
CXR04_RS10900	COG0667	Aldo Keto reductase
CXR04_RS10910	COG4106	trans-aconitate 2-methyltransferase activity
CXR04_RS10950	COG2815	serine threonine protein kinase
CXR04_RS10950	COG0515	serine threonine protein kinase
CXR04_RS10955	COG4941	Belongs to the sigma-70 factor family
CXR04_RS10995	COG0583	DNA-binding transcription factor activity
CXR04_RS11025	COG1597	lipid kinase activity
CXR04_RS11040	COG1309	transcriptional regulator
CXR04_RS11045	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS11050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXR04_RS11055	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR04_RS11060	COG0395	ABC-type sugar transport system, permease component
CXR04_RS11065	COG1175	transmembrane transport
CXR04_RS11070	COG2182	Extracellular solute-binding protein
CXR04_RS11075	COG2188	Transcriptional regulator
CXR04_RS11080	COG0667	Aldo Keto reductase
CXR04_RS11085	COG1966	Carbon starvation protein
CXR04_RS11105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXR04_RS11115	COG0242	peptide deformylase activity
CXR04_RS11135	COG5662	AntiSigma factor
CXR04_RS11140	COG1595	DNA-templated transcription, initiation
CXR04_RS11150	COG2135	peptidase activity
CXR04_RS11160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXR04_RS11165	COG1162	GTPase activity
CXR04_RS11170	COG2076	Multidrug Resistance protein
CXR04_RS11180	COG0483	inositol monophosphate 1-phosphatase activity
CXR04_RS11210	COG1615	UPF0182 protein
CXR04_RS11220	COG3480	Lon protease (S16) C-terminal proteolytic domain
CXR04_RS11255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXR04_RS11285	COG2816	NAD+ diphosphatase activity
CXR04_RS11290	COG0210	DNA helicase
CXR04_RS11385	COG0513	Belongs to the DEAD box helicase family
CXR04_RS11400	COG2095	MarC family integral membrane protein
CXR04_RS11405	COG0613	PHP domain protein
CXR04_RS11420	COG0598	Magnesium transport protein CorA
CXR04_RS11445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR04_RS11450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR04_RS11460	COG1595	DNA-templated transcription, initiation
CXR04_RS11475	COG1024	Enoyl-CoA hydratase
CXR04_RS11480	COG0519	Catalyzes the synthesis of GMP from XMP
CXR04_RS11490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CXR04_RS11495	COG1611	Belongs to the LOG family
CXR04_RS11500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR04_RS11535	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS11545	COG0601	transmembrane transport
CXR04_RS11550	COG0747	negative chemotaxis
CXR04_RS11555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS11570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR04_RS11590	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS11595	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS11600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS11605	COG0601	transmembrane transport
CXR04_RS11615	COG1217	gtp-binding protein TYPA
CXR04_RS11640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXR04_RS11645	COG2027	D-alanyl-D-alanine carboxypeptidase
CXR04_RS11660	COG1842	Phage shock protein A
CXR04_RS11685	COG2239	Acts as a magnesium transporter
CXR04_RS11700	COG0789	Transcriptional regulator
CXR04_RS11710	COG1136	(ABC) transporter
CXR04_RS11735	COG0577	efflux transmembrane transporter activity
CXR04_RS11735	COG1136	(ABC) transporter
CXR04_RS11740	COG0577	efflux transmembrane transporter activity
CXR04_RS11745	COG0488	(ABC) transporter
CXR04_RS11765	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS11770	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS11775	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS11780	COG0601	transmembrane transport
CXR04_RS11785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS11830	COG2409	Drug exporters of the RND superfamily
CXR04_RS11835	COG0243	molybdopterin cofactor binding
CXR04_RS11845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXR04_RS11845	COG2146	nitrite reductase [NAD(P)H] activity
CXR04_RS11880	COG4585	Histidine kinase
CXR04_RS11885	COG2197	response regulator
CXR04_RS11890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXR04_RS11895	COG1937	Protein conserved in bacteria
CXR04_RS11900	COG0730	response to heat
CXR04_RS11915	COG0702	epimerase
CXR04_RS11975	COG0501	Belongs to the peptidase M48B family
CXR04_RS12070	COG0012	GTP binding
CXR04_RS12080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXR04_RS12085	COG1570	exodeoxyribonuclease VII activity
CXR04_RS12090	COG1722	exodeoxyribonuclease VII activity
CXR04_RS12115	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CXR04_RS12115	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CXR04_RS12125	COG0114	fumarate hydratase activity
CXR04_RS12165	COG1136	(ABC) transporter
CXR04_RS12175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR04_RS12190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXR04_RS12195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR04_RS12200	COG0667	Aldo Keto reductase
CXR04_RS12235	COG2885	chlorophyll binding
CXR04_RS12320	COG0251	oxidation-reduction process
CXR04_RS12325	COG1414	Transcriptional regulator
CXR04_RS12335	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CXR04_RS12350	COG1331	Highly conserved protein containing a thioredoxin domain
CXR04_RS12355	COG1309	transcriptional regulator
CXR04_RS12360	COG0477	Major facilitator Superfamily
CXR04_RS12375	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CXR04_RS12380	COG2255	four-way junction helicase activity
CXR04_RS12390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CXR04_RS12400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXR04_RS12415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXR04_RS12445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXR04_RS12450	COG3467	pyridoxamine 5'-phosphate
CXR04_RS12470	COG4977	sequence-specific DNA binding
CXR04_RS12480	COG2226	methyltransferase
CXR04_RS12495	COG1136	(ABC) transporter
CXR04_RS12500	COG0577	efflux transmembrane transporter activity
CXR04_RS12505	COG1376	ErfK ybiS ycfS ynhG family protein
CXR04_RS12510	COG2986	histidine ammonia-lyase
CXR04_RS12515	COG1024	Enoyl-CoA hydratase
CXR04_RS12525	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CXR04_RS12535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR04_RS12545	COG0424	maF-like protein
CXR04_RS12555	COG4770	biotin carboxylase activity
CXR04_RS12585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR04_RS12605	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS12610	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS12615	COG1595	DNA-templated transcription, initiation
CXR04_RS12620	COG0745	RESPONSE REGULATOR receiver
CXR04_RS12625	COG2205	protein histidine kinase activity
CXR04_RS12655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CXR04_RS12665	COG0583	DNA-binding transcription factor activity
CXR04_RS12670	COG2814	Major facilitator Superfamily
CXR04_RS12675	COG1744	ABC transporter substrate-binding protein PnrA-like
CXR04_RS12680	COG3845	ABC transporter
CXR04_RS12685	COG4603	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS12690	COG1079	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS12710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXR04_RS12725	COG2009	succinate dehydrogenase
CXR04_RS12735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CXR04_RS12755	COG1595	DNA-templated transcription, initiation
CXR04_RS12775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CXR04_RS12775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CXR04_RS12800	COG1309	transcriptional regulator
CXR04_RS12810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CXR04_RS12810	COG1473	amidohydrolase
CXR04_RS12820	COG2089	acid synthase
CXR04_RS12825	COG1083	cytidylyl-transferase
CXR04_RS12835	COG1216	Glycosyl transferase, family 2
CXR04_RS12850	COG0477	Major facilitator Superfamily
CXR04_RS12855	COG2409	Drug exporters of the RND superfamily
CXR04_RS12860	COG2205	protein histidine kinase activity
CXR04_RS12880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXR04_RS12885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXR04_RS12900	COG0180	Tryptophanyl-tRNA synthetase
CXR04_RS12915	COG1686	Belongs to the peptidase S11 family
CXR04_RS12945	COG1408	metallophosphoesterase
CXR04_RS12950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR04_RS12955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR04_RS12975	COG0039	L-malate dehydrogenase activity
CXR04_RS12990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXR04_RS13000	COG0138	bifunctional purine biosynthesis protein purh
CXR04_RS13030	COG0045	succinate-CoA ligase (ADP-forming) activity
CXR04_RS13035	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CXR04_RS13040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CXR04_RS13045	COG0714	Associated with various cellular activities
CXR04_RS13060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CXR04_RS13090	COG2197	response regulator
CXR04_RS13120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXR04_RS13120	COG0519	Catalyzes the synthesis of GMP from XMP
CXR04_RS13140	COG0483	inositol monophosphate 1-phosphatase activity
CXR04_RS13165	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS13170	COG2815	serine threonine protein kinase
CXR04_RS13170	COG0515	serine threonine protein kinase
CXR04_RS13195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CXR04_RS13225	COG0516	GMP reductase activity
CXR04_RS13235	COG1595	DNA-templated transcription, initiation
CXR04_RS13250	COG0583	DNA-binding transcription factor activity
CXR04_RS13260	COG2132	Multicopper oxidase
CXR04_RS13265	COG0300	oxidoreductase activity
CXR04_RS13270	COG0459	protein refolding
CXR04_RS13275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXR04_RS13280	COG0726	polysaccharide deacetylase
CXR04_RS13300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXR04_RS13350	COG0802	atpase or kinase
CXR04_RS13360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXR04_RS13375	COG0736	holo-[acyl-carrier-protein] synthase activity
CXR04_RS13385	COG1072	(Pantothenic acid kinase))
CXR04_RS13395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR04_RS13400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXR04_RS13405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXR04_RS13410	COG0488	(ABC) transporter
CXR04_RS13425	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR04_RS13430	COG0101	tRNA pseudouridine synthase activity
CXR04_RS13435	COG0203	ribosomal protein L17
CXR04_RS13440	COG0202	RNA polymerase activity
CXR04_RS13445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXR04_RS13450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXR04_RS13455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXR04_RS13460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXR04_RS13465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXR04_RS13475	COG0563	adenylate kinase activity
CXR04_RS13485	COG0200	Binds to the 23S rRNA
CXR04_RS13490	COG1841	ribosomal large subunit assembly
CXR04_RS13495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXR04_RS13500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CXR04_RS13505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXR04_RS13510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXR04_RS13520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXR04_RS13525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXR04_RS13530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXR04_RS13535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXR04_RS13540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXR04_RS13545	COG0255	Belongs to the universal ribosomal protein uL29 family
CXR04_RS13550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXR04_RS13555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXR04_RS13560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXR04_RS13565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXR04_RS13570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXR04_RS13575	COG0089	rRNA binding
CXR04_RS13580	COG0088	Forms part of the polypeptide exit tunnel
CXR04_RS13585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXR04_RS13590	COG0051	transcription antitermination factor activity, RNA binding
CXR04_RS13600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR04_RS13615	COG1515	deoxyribonuclease V activity
CXR04_RS13635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXR04_RS13640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXR04_RS13645	COG0049	tRNA binding
CXR04_RS13650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXR04_RS13660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXR04_RS13665	COG0085	RNA polymerase activity
CXR04_RS13675	COG0222	ribosome binding
CXR04_RS13680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXR04_RS13695	COG0081	regulation of translation
CXR04_RS13700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXR04_RS13720	COG0436	Aminotransferase
CXR04_RS13725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CXR04_RS13740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXR04_RS13755	COG0586	Pfam SNARE associated Golgi protein
CXR04_RS13760	COG4585	Histidine kinase
CXR04_RS13765	COG2201	protein-glutamate methylesterase activity
CXR04_RS13815	COG0604	alcohol dehydrogenase
CXR04_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS13815	COG3321	synthase
CXR04_RS13835	COG1666	GTP binding
CXR04_RS13870	COG3152	Membrane
CXR04_RS13875	COG0590	tRNA wobble adenosine to inosine editing
CXR04_RS13890	COG0346	lactoylglutathione lyase activity
CXR04_RS13910	COG0640	Transcriptional regulator
CXR04_RS13915	COG0154	amidase activity
CXR04_RS13920	COG0702	epimerase
CXR04_RS13940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXR04_RS13945	COG2030	dehydratase
CXR04_RS13960	COG0477	Major facilitator Superfamily
CXR04_RS13995	COG0501	Belongs to the peptidase M48B family
CXR04_RS14000	COG1007	ATP synthesis coupled electron transport
CXR04_RS14015	COG0713	ATP synthesis coupled electron transport
CXR04_RS14020	COG0839	Belongs to the complex I subunit 6 family
CXR04_RS14025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS14035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS14040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS14045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS14050	COG4585	Histidine kinase
CXR04_RS14055	COG4585	Histidine kinase
CXR04_RS14065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CXR04_RS14065	COG0674	pyruvate-flavodoxin oxidoreductase activity
CXR04_RS14070	COG1013	pyruvate-flavodoxin oxidoreductase activity
CXR04_RS14075	COG1733	regulation of RNA biosynthetic process
CXR04_RS14080	COG0702	epimerase
CXR04_RS14120	COG0142	geranyltranstransferase activity
CXR04_RS14130	COG1007	ATP synthesis coupled electron transport
CXR04_RS14140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXR04_RS14145	COG0713	ATP synthesis coupled electron transport
CXR04_RS14150	COG0839	Belongs to the complex I subunit 6 family
CXR04_RS14155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS14160	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CXR04_RS14165	COG1034	ATP synthesis coupled electron transport
CXR04_RS14170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CXR04_RS14180	COG0649	NAD binding
CXR04_RS14185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS14190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXR04_RS14210	COG2226	methyltransferase
CXR04_RS14215	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CXR04_RS14225	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CXR04_RS14230	COG1278	Cold shock
CXR04_RS14330	COG1301	dicarboxylic acid transport
CXR04_RS14345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CXR04_RS14355	COG0163	prenyltransferase activity
CXR04_RS14380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CXR04_RS14445	COG1278	Cold shock
CXR04_RS14450	COG0513	Belongs to the DEAD box helicase family
CXR04_RS14460	COG1056	cytidyltransferase-related domain
CXR04_RS14460	COG1051	belongs to the nudix hydrolase family
CXR04_RS14490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXR04_RS14495	COG0406	alpha-ribazole phosphatase activity
CXR04_RS14500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXR04_RS14505	COG0785	Cytochrome C biogenesis protein
CXR04_RS14510	COG1333	cytochrome c biogenesis protein
CXR04_RS14515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXR04_RS14535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXR04_RS14585	COG3387	PFAM Glycoside hydrolase 15-related
CXR04_RS14590	COG0406	alpha-ribazole phosphatase activity
CXR04_RS14610	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CXR04_RS14615	COG0018	arginyl-trna synthetase
CXR04_RS14620	COG0596	Alpha beta hydrolase
CXR04_RS14635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXR04_RS14650	COG0113	porphobilinogen synthase activity
CXR04_RS14655	COG1648	precorrin-2 dehydrogenase activity
CXR04_RS14655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXR04_RS14660	COG0181	hydroxymethylbilane synthase activity
CXR04_RS14665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXR04_RS14670	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CXR04_RS14720	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXR04_RS14780	COG0579	oxidoreductase
CXR04_RS14785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CXR04_RS14940	COG3973	AAA domain
CXR04_RS14945	COG0515	serine threonine protein kinase
CXR04_RS14945	COG2815	serine threonine protein kinase
CXR04_RS14950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXR04_RS14990	COG1070	Carbohydrate kinase
CXR04_RS15000	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS15005	COG1129	ABC transporter
CXR04_RS15015	COG0395	ABC-type sugar transport system, permease component
CXR04_RS15025	COG1175	transmembrane transport
CXR04_RS15045	COG1609	Transcriptional regulator
CXR04_RS15080	COG1737	Transcriptional regulator
CXR04_RS15085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CXR04_RS15095	COG1278	Cold shock
CXR04_RS15110	COG0463	Glycosyl transferase, family 2
CXR04_RS15125	COG0596	Alpha beta hydrolase
CXR04_RS15145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXR04_RS15185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXR04_RS15240	COG4948	Mandelate Racemase Muconate Lactonizing
CXR04_RS15280	COG2226	methyltransferase
CXR04_RS15295	COG1473	amidohydrolase
CXR04_RS15315	COG1131	(ABC) transporter
CXR04_RS15350	COG3629	intracellular signal transduction
CXR04_RS15350	COG3903	Transcriptional regulator
CXR04_RS15370	COG0443	Heat shock 70 kDa protein
CXR04_RS15395	COG3629	intracellular signal transduction
CXR04_RS15395	COG3903	Transcriptional regulator
CXR04_RS15455	COG1082	Xylose isomerase domain protein TIM barrel
CXR04_RS15460	COG1687	branched-chain amino acid
CXR04_RS15465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CXR04_RS15470	COG1522	sequence-specific DNA binding
CXR04_RS15485	COG1940	carbohydrate kinase activity
CXR04_RS15490	COG3291	Pkd domain containing protein
CXR04_RS15530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXR04_RS15555	COG2226	methyltransferase
CXR04_RS15590	COG2610	gluconate transmembrane transporter activity
CXR04_RS15595	COG3265	gluconokinase activity
CXR04_RS15600	COG2186	Transcriptional regulator
CXR04_RS15605	COG2409	Drug exporters of the RND superfamily
CXR04_RS15610	COG1595	DNA-templated transcription, initiation
CXR04_RS15620	COG5297	Belongs to the glycosyl hydrolase family 6
CXR04_RS15635	COG1404	Belongs to the peptidase S8 family
CXR04_RS15670	COG1643	Atp-dependent helicase
CXR04_RS15695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CXR04_RS15705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXR04_RS15710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CXR04_RS15765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXR04_RS15770	COG0047	phosphoribosylformylglycinamidine synthase activity
CXR04_RS15775	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXR04_RS15795	COG1131	(ABC) transporter
CXR04_RS15805	COG3851	Histidine kinase
CXR04_RS15810	COG2197	response regulator
CXR04_RS15820	COG1194	a g-specific adenine glycosylase
CXR04_RS15825	COG0346	lactoylglutathione lyase activity
CXR04_RS15865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CXR04_RS15880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CXR04_RS15885	COG0157	Belongs to the NadC ModD family
CXR04_RS15890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CXR04_RS15895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXR04_RS15910	COG0640	Transcriptional regulator
CXR04_RS15935	COG0517	IMP dehydrogenase activity
CXR04_RS15935	COG1125	glycine betaine transport
CXR04_RS15945	COG1174	glycine betaine transport
CXR04_RS15970	COG0649	NAD binding
CXR04_RS15985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CXR04_RS15995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CXR04_RS16000	COG0302	gtp cyclohydrolase
CXR04_RS16010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXR04_RS16015	COG0037	tRNA processing
CXR04_RS16035	COG0581	inorganic phosphate transmembrane transporter activity
CXR04_RS16040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR04_RS16045	COG0306	phosphate transporter
CXR04_RS16055	COG1937	Protein conserved in bacteria
CXR04_RS16075	COG0277	FAD linked oxidase domain protein
CXR04_RS16080	COG0671	phosphoesterase, PA-phosphatase related
CXR04_RS16085	COG1196	nuclear chromosome segregation
CXR04_RS16085	COG0741	lytic transglycosylase activity
CXR04_RS16085	COG0739	heme binding
CXR04_RS16155	COG0180	Tryptophanyl-tRNA synthetase
CXR04_RS16165	COG4585	Histidine kinase
CXR04_RS16175	COG2197	response regulator
CXR04_RS16180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CXR04_RS16190	COG0842	Transport permease protein
CXR04_RS16190	COG1129	ABC transporter
CXR04_RS16195	COG2409	Drug exporters of the RND superfamily
CXR04_RS16210	COG2814	Major facilitator Superfamily
CXR04_RS16225	COG0129	dihydroxy-acid dehydratase activity
CXR04_RS16235	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CXR04_RS16245	COG0671	phosphoesterase, PA-phosphatase related
CXR04_RS16260	COG0248	Ppx GppA phosphatase
CXR04_RS16265	COG1082	Xylose isomerase domain protein TIM barrel
CXR04_RS16270	COG1309	transcriptional regulator
CXR04_RS16275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXR04_RS16280	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXR04_RS16280	COG1902	pentaerythritol trinitrate reductase activity
CXR04_RS16310	COG0596	Alpha beta hydrolase
CXR04_RS16330	COG0151	Belongs to the GarS family
CXR04_RS16365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS16365	COG0515	serine threonine protein kinase
CXR04_RS16370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXR04_RS16400	COG1131	(ABC) transporter
CXR04_RS16405	COG3559	Exporter of polyketide antibiotics
CXR04_RS16410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXR04_RS16445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXR04_RS16465	COG3844	kynureninase activity
CXR04_RS16480	COG0542	response to heat
CXR04_RS16505	COG2197	response regulator
CXR04_RS16515	COG0789	Transcriptional regulator
CXR04_RS16520	COG0484	heat shock protein binding
CXR04_RS16525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXR04_RS16530	COG0443	Heat shock 70 kDa protein
CXR04_RS16535	COG0247	lactate metabolic process
CXR04_RS16535	COG2181	nitrate reductase activity
CXR04_RS16560	COG0717	Belongs to the dCTP deaminase family
CXR04_RS16720	COG0494	nUDIX hydrolase
CXR04_RS16735	COG2326	polyphosphate kinase activity
CXR04_RS16760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CXR04_RS16770	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CXR04_RS16780	COG0569	domain protein
CXR04_RS16785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXR04_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS16840	COG1309	transcriptional regulator
CXR04_RS16895	COG1253	flavin adenine dinucleotide binding
CXR04_RS16920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR04_RS16930	COG3903	Transcriptional regulator
CXR04_RS16930	COG3629	intracellular signal transduction
CXR04_RS16940	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS16945	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS16950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS16955	COG0601	transmembrane transport
CXR04_RS16985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXR04_RS17000	COG3119	arylsulfatase activity
CXR04_RS17035	COG5650	phosphatidylinositol metabolic process
CXR04_RS17060	COG0328	RNA-DNA hybrid ribonuclease activity
CXR04_RS17070	COG3209	COG3209 Rhs family protein
CXR04_RS17080	COG0142	geranyltranstransferase activity
CXR04_RS17150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXR04_RS17150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXR04_RS17210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CXR04_RS17215	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS17225	COG2815	serine threonine protein kinase
CXR04_RS17225	COG0515	serine threonine protein kinase
CXR04_RS17265	COG0601	transmembrane transport
CXR04_RS17270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS17280	COG4172	Belongs to the ABC transporter superfamily
CXR04_RS17295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXR04_RS17300	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS17355	COG1595	DNA-templated transcription, initiation
CXR04_RS17400	COG0789	Transcriptional regulator
CXR04_RS17415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXR04_RS17455	COG1595	DNA-templated transcription, initiation
CXR04_RS17480	COG1733	regulation of RNA biosynthetic process
CXR04_RS17490	COG1672	PFAM Archaeal ATPase
CXR04_RS17490	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CXR04_RS17580	COG0542	response to heat
CXR04_RS17630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR04_RS17675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CXR04_RS17680	COG0745	RESPONSE REGULATOR receiver
CXR04_RS17685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CXR04_RS17700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR04_RS17710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXR04_RS17720	COG1741	Belongs to the pirin family
CXR04_RS17730	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS17740	COG1362	aminopeptidase activity
CXR04_RS17775	COG1077	Cell shape determining protein MreB Mrl
CXR04_RS17780	COG2271	Major facilitator Superfamily
CXR04_RS17790	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR04_RS17795	COG0022	dehydrogenase e1 component
CXR04_RS17810	COG0515	serine threonine protein kinase
CXR04_RS17815	COG0515	serine threonine protein kinase
CXR04_RS17835	COG0604	alcohol dehydrogenase
CXR04_RS17840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXR04_RS17870	COG1522	sequence-specific DNA binding
CXR04_RS17875	COG1309	transcriptional regulator
CXR04_RS17905	COG3396	Phenylacetate-CoA oxygenase
CXR04_RS17910	COG3460	Phenylacetate-CoA oxygenase
CXR04_RS17915	COG3396	Phenylacetate-CoA oxygenase
CXR04_RS17920	COG2151	metal-sulfur cluster biosynthetic enzyme
CXR04_RS17925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXR04_RS17950	COG1716	ATPase activity
CXR04_RS17955	COG1716	ATPase activity
CXR04_RS17975	COG0515	serine threonine protein kinase
CXR04_RS17995	COG0705	Rhomboid family
CXR04_RS18015	COG3764	Sortase (surface protein transpeptidase)
CXR04_RS18020	COG3764	Sortase (surface protein transpeptidase)
CXR04_RS18030	COG0515	serine threonine protein kinase
CXR04_RS18060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CXR04_RS18070	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CXR04_RS18075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXR04_RS18080	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CXR04_RS18085	COG0592	DNA-directed DNA polymerase activity
CXR04_RS18090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXR04_RS18100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CXR04_RS18105	COG0594	ribonuclease P activity
CXR04_RS18110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXR04_RS18115	COG0706	membrane insertase activity
CXR04_RS18125	COG0357	Ribosomal RNA small subunit methyltransferase G
CXR04_RS18130	COG1192	Involved in chromosome partitioning
CXR04_RS18145	COG3118	belongs to the thioredoxin family
CXR04_RS18150	COG0492	ferredoxin-NADP+ reductase activity
CXR04_RS18160	COG1595	DNA-templated transcription, initiation
CXR04_RS18165	COG2815	serine threonine protein kinase
CXR04_RS18165	COG0515	serine threonine protein kinase
CXR04_RS18170	COG0728	peptidoglycan biosynthetic process
CXR04_RS18180	COG0617	tRNA 3'-terminal CCA addition
CXR04_RS18190	COG1260	myo-inositol-1-phosphate synthase
CXR04_RS18195	COG1695	Transcriptional regulator
CXR04_RS18200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR04_RS18225	COG0360	Binds together with S18 to 16S ribosomal RNA
CXR04_RS18235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXR04_RS18240	COG0359	binds to the 23S rRNA
CXR04_RS18275	COG0242	peptide deformylase activity
CXR04_RS18295	COG1131	(ABC) transporter
CXR04_RS18305	COG1131	(ABC) transporter
CXR04_RS18350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR04_RS18360	COG0583	DNA-binding transcription factor activity
CXR04_RS18370	COG0561	phosphatase activity
CXR04_RS18380	COG4988	ABC transporter
CXR04_RS18385	COG1294	oxidase, subunit
CXR04_RS18390	COG1271	oxidase subunit
CXR04_RS18395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR04_RS18400	COG1609	Transcriptional regulator
CXR04_RS18405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXR04_RS18430	COG0626	cystathionine gamma-synthase activity
CXR04_RS18435	COG3001	Fructosamine kinase
CXR04_RS18440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR04_RS18445	COG1950	PFAM Membrane protein of
CXR04_RS18450	COG0662	Cupin 2, conserved barrel domain protein
CXR04_RS18465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CXR04_RS18505	COG1733	regulation of RNA biosynthetic process
CXR04_RS18520	COG2814	Major facilitator Superfamily
CXR04_RS18560	COG0583	DNA-binding transcription factor activity
CXR04_RS18565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR04_RS18570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR04_RS18575	COG2197	response regulator
CXR04_RS18585	COG1131	(ABC) transporter
CXR04_RS18620	COG1280	lysine exporter protein (LysE YggA)
CXR04_RS18625	COG0583	DNA-binding transcription factor activity
CXR04_RS18635	COG0561	phosphatase activity
CXR04_RS18640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXR04_RS18650	COG2837	iron assimilation
CXR04_RS18655	COG2372	response to copper ion
CXR04_RS18705	COG0076	glutamate decarboxylase activity
CXR04_RS18710	COG0402	S-adenosylhomocysteine deaminase activity
CXR04_RS18725	COG0387	Pfam Sodium calcium exchanger
CXR04_RS18750	COG0745	RESPONSE REGULATOR receiver
CXR04_RS18755	COG2972	Histidine kinase
CXR04_RS18755	COG2205	protein histidine kinase activity
CXR04_RS18760	COG0006	proline dipeptidase activity
CXR04_RS18775	COG0653	protein targeting
CXR04_RS18790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR04_RS18840	COG1595	DNA-templated transcription, initiation
CXR04_RS18845	COG0318	PFAM AMP-dependent synthetase and ligase
CXR04_RS18850	COG2204	response regulator
CXR04_RS18860	COG0740	serine-type endopeptidase activity
CXR04_RS18865	COG0740	serine-type endopeptidase activity
CXR04_RS18875	COG1396	sequence-specific DNA binding
CXR04_RS18880	COG2318	DinB family
CXR04_RS18930	COG2188	Transcriptional regulator
CXR04_RS19000	COG1191	sigma factor activity
CXR04_RS19005	COG1191	sigma factor activity
CXR04_RS19030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXR04_RS19060	COG3189	MarR family transcriptional regulator
CXR04_RS19120	COG2814	Major facilitator Superfamily
CXR04_RS19130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXR04_RS19160	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CXR04_RS19165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CXR04_RS19170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CXR04_RS19180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXR04_RS19185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXR04_RS19215	COG2814	Major facilitator Superfamily
CXR04_RS19220	COG0640	Transcriptional regulator
CXR04_RS19260	COG1191	sigma factor activity
CXR04_RS19275	COG1295	ribonuclease BN
CXR04_RS19310	COG1120	ATPase activity
CXR04_RS19355	COG0640	Transcriptional regulator
CXR04_RS19410	COG1136	(ABC) transporter
CXR04_RS19415	COG0577	efflux transmembrane transporter activity
CXR04_RS19425	COG0745	RESPONSE REGULATOR receiver
CXR04_RS19430	COG2205	protein histidine kinase activity
CXR04_RS19435	COG1278	Cold shock
CXR04_RS19460	COG2226	methyltransferase
CXR04_RS19460	COG2867	negative regulation of translational initiation
CXR04_RS19465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR04_RS19470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR04_RS19475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR04_RS19480	COG0662	Cupin 2, conserved barrel domain protein
CXR04_RS19485	COG2226	methyltransferase
CXR04_RS19500	COG0640	Transcriptional regulator
CXR04_RS19560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXR04_RS19565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXR04_RS19605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXR04_RS19635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXR04_RS19660	COG2318	DinB family
CXR04_RS19710	COG2815	serine threonine protein kinase
CXR04_RS19710	COG0515	serine threonine protein kinase
CXR04_RS19720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CXR04_RS19750	COG1401	restriction endodeoxyribonuclease activity
CXR04_RS19800	COG1408	metallophosphoesterase
CXR04_RS19810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR04_RS19825	COG0003	Pfam Anion-transporting ATPase
CXR04_RS19845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXR04_RS19870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CXR04_RS19895	COG2268	Band 7 protein
CXR04_RS19920	COG2267	carboxylic ester hydrolase activity
CXR04_RS19935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR04_RS19940	COG0659	secondary active sulfate transmembrane transporter activity
CXR04_RS20005	COG1111	helicase
CXR04_RS20005	COG1205	dead DEAH box helicase
CXR04_RS20010	COG1366	Belongs to the anti-sigma-factor antagonist family
CXR04_RS20015	COG2172	sigma factor antagonist activity
CXR04_RS20020	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CXR04_RS20045	COG1754	DNA topoisomerase type I activity
CXR04_RS20045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CXR04_RS20050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXR04_RS20065	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS20075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR04_RS20080	COG4521	taurine ABC transporter
CXR04_RS20085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS20090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXR04_RS20105	COG4948	Mandelate Racemase Muconate Lactonizing
CXR04_RS20115	COG0459	protein refolding
CXR04_RS20120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CXR04_RS20245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXR04_RS20265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXR04_RS20275	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CXR04_RS20285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CXR04_RS20320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXR04_RS20325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CXR04_RS20330	COG2080	2 iron, 2 sulfur cluster binding
CXR04_RS20395	COG3291	Pkd domain containing protein
CXR04_RS20405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXR04_RS20405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CXR04_RS20410	COG0583	DNA-binding transcription factor activity
CXR04_RS20430	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS20435	COG2508	Transcriptional regulator
CXR04_RS20435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CXR04_RS20455	COG3069	C4-dicarboxylate transmembrane transporter activity
CXR04_RS20485	COG1525	nuclease
CXR04_RS20485	COG0737	Belongs to the 5'-nucleotidase family
CXR04_RS20485	COG4085	toxin activity
CXR04_RS20520	COG1129	ABC transporter
CXR04_RS20525	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS20530	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS20550	COG0739	heme binding
CXR04_RS20555	COG1764	response to oxidative stress
CXR04_RS20580	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS20585	COG1309	transcriptional regulator
CXR04_RS20645	COG0745	RESPONSE REGULATOR receiver
CXR04_RS20650	COG5002	protein histidine kinase activity
CXR04_RS20660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXR04_RS20665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CXR04_RS20695	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS20725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CXR04_RS20730	COG2027	D-alanyl-D-alanine carboxypeptidase
CXR04_RS20835	COG4552	Acetyltransferase involved in intracellular survival and related
CXR04_RS20850	COG1490	D-aminoacyl-tRNA deacylase activity
CXR04_RS20855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXR04_RS20860	COG0735	belongs to the Fur family
CXR04_RS20865	COG3485	protocatechuate 3,4-dioxygenase
CXR04_RS20905	COG2897	thiosulfate sulfurtransferase activity
CXR04_RS20945	COG0745	RESPONSE REGULATOR receiver
CXR04_RS20950	COG1609	Transcriptional regulator
CXR04_RS20975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR04_RS20980	COG0745	RESPONSE REGULATOR receiver
CXR04_RS21005	COG0737	Belongs to the 5'-nucleotidase family
CXR04_RS21010	COG0456	acetyltransferase
CXR04_RS21015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CXR04_RS21025	COG0494	nUDIX hydrolase
CXR04_RS21025	COG0406	alpha-ribazole phosphatase activity
CXR04_RS21045	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS21065	COG0588	phosphoglycerate mutase activity
CXR04_RS21075	COG5002	protein histidine kinase activity
CXR04_RS21095	COG1329	Transcriptional regulator
CXR04_RS21100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CXR04_RS21105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXR04_RS21115	COG0215	cysteine-tRNA ligase activity
CXR04_RS21120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXR04_RS21130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CXR04_RS21140	COG3842	ATPase activity
CXR04_RS21150	COG2814	Major facilitator Superfamily
CXR04_RS21190	COG0395	ABC-type sugar transport system, permease component
CXR04_RS21235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CXR04_RS21250	COG1486	melibiose metabolic process
CXR04_RS21260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR04_RS21270	COG1175	transmembrane transport
CXR04_RS21275	COG0395	ABC-type sugar transport system, permease component
CXR04_RS21280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR04_RS21290	COG3718	enzyme involved in inositol metabolism
CXR04_RS21295	COG3962	Belongs to the TPP enzyme family
CXR04_RS21305	COG1082	Xylose isomerase domain protein TIM barrel
CXR04_RS21310	COG0673	inositol 2-dehydrogenase activity
CXR04_RS21320	COG1061	Type III restriction enzyme res subunit
CXR04_RS21345	COG2814	Major facilitator Superfamily
CXR04_RS21360	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CXR04_RS21365	COG1278	Cold shock
CXR04_RS21400	COG1846	Transcriptional regulator
CXR04_RS21410	COG2252	PERMEase
CXR04_RS21420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CXR04_RS21430	COG0667	Aldo Keto reductase
CXR04_RS21455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXR04_RS21475	COG0277	FAD linked oxidase domain protein
CXR04_RS21475	COG0247	lactate metabolic process
CXR04_RS21490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR04_RS21495	COG4770	biotin carboxylase activity
CXR04_RS21505	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CXR04_RS21520	COG0259	pyridoxamine-phosphate oxidase activity
CXR04_RS21535	COG0596	Alpha beta hydrolase
CXR04_RS21535	COG2945	thiolester hydrolase activity
CXR04_RS21545	COG1674	ftsk spoiiie
CXR04_RS21680	COG1476	TRANSCRIPTIONal
CXR04_RS21700	COG0477	Major facilitator Superfamily
CXR04_RS21730	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS21745	COG2318	DinB family
CXR04_RS21795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXR04_RS21800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS21800	COG0515	serine threonine protein kinase
CXR04_RS21810	COG1309	transcriptional regulator
CXR04_RS21815	COG2072	flavoprotein involved in K transport
CXR04_RS21820	COG2813	Specifically methylates the guanine in position
CXR04_RS21825	COG2197	response regulator
CXR04_RS21875	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CXR04_RS21895	COG1733	regulation of RNA biosynthetic process
CXR04_RS21970	COG3118	belongs to the thioredoxin family
CXR04_RS21990	COG0477	Major facilitator Superfamily
CXR04_RS22020	COG0484	heat shock protein binding
CXR04_RS22035	COG0667	Aldo Keto reductase
CXR04_RS22100	COG2837	iron assimilation
CXR04_RS22155	COG3835	regulator
CXR04_RS22190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXR04_RS22215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXR04_RS22250	COG1764	response to oxidative stress
CXR04_RS22265	COG3384	dioxygenase
CXR04_RS22295	COG1970	mechanosensitive ion channel activity
CXR04_RS22305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CXR04_RS22320	COG3263	regulation of cellular component size
CXR04_RS22330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CXR04_RS22330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CXR04_RS22335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CXR04_RS22345	COG0315	cyclic pyranopterin monophosphate synthase activity
CXR04_RS22350	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXR04_RS22355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR04_RS22385	COG0366	Alpha amylase catalytic
CXR04_RS22390	COG3119	arylsulfatase activity
CXR04_RS22415	COG1175	transmembrane transport
CXR04_RS22445	COG1609	Transcriptional regulator
CXR04_RS22475	COG2050	protein possibly involved in aromatic compounds catabolism
CXR04_RS22480	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXR04_RS22500	COG4941	Belongs to the sigma-70 factor family
CXR04_RS22520	COG2072	flavoprotein involved in K transport
CXR04_RS22525	COG2267	carboxylic ester hydrolase activity
CXR04_RS22540	COG4946	Tricorn protease homolog
CXR04_RS22540	COG0793	Belongs to the peptidase S41A family
CXR04_RS22560	COG0442	prolyl-tRNA aminoacylation
CXR04_RS22565	COG0768	penicillin binding
CXR04_RS22590	COG0084	hydrolase, TatD family'
CXR04_RS22595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXR04_RS22600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXR04_RS22605	COG0488	(ABC) transporter
CXR04_RS22615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CXR04_RS22645	COG2197	response regulator
CXR04_RS22650	COG2197	response regulator
CXR04_RS22660	COG4106	trans-aconitate 2-methyltransferase activity
CXR04_RS22670	COG1309	transcriptional regulator
CXR04_RS22680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CXR04_RS22690	COG0193	aminoacyl-tRNA hydrolase activity
CXR04_RS22695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXR04_RS22700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXR04_RS22705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXR04_RS22720	COG4585	Histidine kinase
CXR04_RS22755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXR04_RS22780	COG0577	efflux transmembrane transporter activity
CXR04_RS22785	COG1136	(ABC) transporter
CXR04_RS22805	COG2318	DinB family
CXR04_RS22835	COG0640	Transcriptional regulator
CXR04_RS22860	COG1216	Glycosyl transferase, family 2
CXR04_RS22890	COG2124	cytochrome p450
CXR04_RS22895	COG1652	LysM domain
CXR04_RS22900	COG1652	LysM domain
CXR04_RS22905	COG0148	phosphopyruvate hydratase activity
CXR04_RS22940	COG2188	Transcriptional regulator
CXR04_RS22945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CXR04_RS22955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CXR04_RS22985	COG2755	lipolytic protein G-D-S-L family
CXR04_RS23015	COG1136	(ABC) transporter
CXR04_RS23020	COG0577	efflux transmembrane transporter activity
CXR04_RS23040	COG0183	Belongs to the thiolase family
CXR04_RS23050	COG0259	pyridoxamine-phosphate oxidase activity
CXR04_RS23065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CXR04_RS23080	COG1228	amidohydrolase
CXR04_RS23090	COG1191	sigma factor activity
CXR04_RS23110	COG0745	RESPONSE REGULATOR receiver
CXR04_RS23115	COG2205	protein histidine kinase activity
CXR04_RS23130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CXR04_RS23165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CXR04_RS23170	COG1316	TRANSCRIPTIONal
CXR04_RS23195	COG1316	TRANSCRIPTIONal
CXR04_RS23200	COG1316	TRANSCRIPTIONal
CXR04_RS23205	COG1316	TRANSCRIPTIONal
CXR04_RS23215	COG1316	TRANSCRIPTIONal
CXR04_RS23225	COG1316	TRANSCRIPTIONal
CXR04_RS23230	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CXR04_RS23230	COG0778	Nitroreductase
CXR04_RS23235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CXR04_RS23270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXR04_RS23285	COG1482	cell wall glycoprotein biosynthetic process
CXR04_RS23295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXR04_RS23320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CXR04_RS23325	COG0745	RESPONSE REGULATOR receiver
CXR04_RS23330	COG5000	phosphorelay sensor kinase activity
CXR04_RS23330	COG5002	protein histidine kinase activity
CXR04_RS23335	COG0823	Involved in the tonB-independent uptake of proteins
CXR04_RS23345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CXR04_RS23350	COG2197	response regulator
CXR04_RS23355	COG3214	Protein conserved in bacteria
CXR04_RS23370	COG0653	protein targeting
CXR04_RS23400	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS23415	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS23420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CXR04_RS23425	COG0395	ABC-type sugar transport system, permease component
CXR04_RS23430	COG1175	transmembrane transport
CXR04_RS23435	COG1653	transport
CXR04_RS23440	COG1716	ATPase activity
CXR04_RS23445	COG0515	serine threonine protein kinase
CXR04_RS23450	COG0515	serine threonine protein kinase
CXR04_RS23455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CXR04_RS23470	COG2884	Cell division ATP-binding protein ftsE
CXR04_RS23475	COG2177	Part of the ABC transporter FtsEX involved in
CXR04_RS23480	COG0793	Belongs to the peptidase S41A family
CXR04_RS23485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXR04_RS23530	COG0583	DNA-binding transcription factor activity
CXR04_RS23535	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CXR04_RS23545	COG0395	ABC-type sugar transport system, permease component
CXR04_RS23555	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR04_RS23560	COG1609	Transcriptional regulator
CXR04_RS23565	COG1501	Belongs to the glycosyl hydrolase 31 family
CXR04_RS23570	COG0395	ABC-type sugar transport system, permease component
CXR04_RS23575	COG1175	transmembrane transport
CXR04_RS23585	COG2130	NADP-dependent
CXR04_RS23590	COG0583	DNA-binding transcription factor activity
CXR04_RS23595	COG2706	6-phosphogluconolactonase activity
CXR04_RS23615	COG0583	DNA-binding transcription factor activity
CXR04_RS23625	COG2223	nitrite transmembrane transporter activity
CXR04_RS23645	COG3973	AAA domain
CXR04_RS23660	COG0776	regulation of translation
CXR04_RS23665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXR04_RS23670	COG1678	Uncharacterized ACR, COG1678
CXR04_RS23680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CXR04_RS23695	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXR04_RS23765	COG1733	regulation of RNA biosynthetic process
CXR04_RS23790	COG0277	FAD linked oxidase domain protein
CXR04_RS23795	COG2755	lipolytic protein G-D-S-L family
CXR04_RS23795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CXR04_RS23800	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CXR04_RS23820	COG4977	sequence-specific DNA binding
CXR04_RS23855	COG1335	isochorismatase
CXR04_RS23865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXR04_RS23875	COG1113	amino acid transport
CXR04_RS23905	COG1234	tRNA 3'-trailer cleavage
CXR04_RS23915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXR04_RS23925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXR04_RS23930	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXR04_RS23935	COG0706	membrane insertase activity
CXR04_RS23945	COG2733	membrane
CXR04_RS23950	COG1309	transcriptional regulator
CXR04_RS23955	COG0477	Major facilitator Superfamily
CXR04_RS23970	COG4555	ABC transporter
CXR04_RS23985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXR04_RS23995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXR04_RS24025	COG0673	inositol 2-dehydrogenase activity
CXR04_RS24035	COG2255	four-way junction helicase activity
CXR04_RS24050	COG1126	abc transporter atp-binding protein
CXR04_RS24055	COG0765	amino acid transport
CXR04_RS24060	COG0765	amino acid transport
CXR04_RS24075	COG0154	amidase activity
CXR04_RS24080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXR04_RS24195	COG5297	Belongs to the glycosyl hydrolase family 6
CXR04_RS24195	COG4733	cellulase activity
CXR04_RS24215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXR04_RS24220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXR04_RS24235	COG4977	sequence-specific DNA binding
CXR04_RS24240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXR04_RS24260	COG3795	YCII-related domain
CXR04_RS24265	COG4941	Belongs to the sigma-70 factor family
CXR04_RS24275	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXR04_RS24305	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS24320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXR04_RS24325	COG1309	transcriptional regulator
CXR04_RS24335	COG1946	Acyl-CoA thioesterase
CXR04_RS24375	COG0583	DNA-binding transcription factor activity
CXR04_RS24405	COG1609	Transcriptional regulator
CXR04_RS24410	COG0673	inositol 2-dehydrogenase activity
CXR04_RS24430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CXR04_RS24450	COG2409	Drug exporters of the RND superfamily
CXR04_RS24475	COG0586	Pfam SNARE associated Golgi protein
CXR04_RS24480	COG0531	amino acid
CXR04_RS24505	COG0726	polysaccharide deacetylase
CXR04_RS24515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CXR04_RS24520	COG2353	YceI-like domain
CXR04_RS24530	COG2234	aminopeptidase activity
CXR04_RS24530	COG4935	Belongs to the peptidase S8 family
CXR04_RS24545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXR04_RS24550	COG2409	Drug exporters of the RND superfamily
CXR04_RS24555	COG4585	Histidine kinase
CXR04_RS24560	COG2197	response regulator
CXR04_RS24570	COG0596	Alpha beta hydrolase
CXR04_RS24575	COG3629	intracellular signal transduction
CXR04_RS24575	COG3903	Transcriptional regulator
CXR04_RS24590	COG0436	Aminotransferase
CXR04_RS24625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXR04_RS24645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXR04_RS24665	COG2239	Acts as a magnesium transporter
CXR04_RS24670	COG0531	amino acid
CXR04_RS24700	COG0629	single-stranded DNA binding
CXR04_RS24725	COG1136	(ABC) transporter
CXR04_RS24725	COG0577	efflux transmembrane transporter activity
CXR04_RS24750	COG1131	(ABC) transporter
CXR04_RS24755	COG1653	transport
CXR04_RS24770	COG0515	serine threonine protein kinase
CXR04_RS24810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXR04_RS24835	COG1653	transport
CXR04_RS24845	COG0395	ABC-type sugar transport system, permease component
CXR04_RS24850	COG1486	melibiose metabolic process
CXR04_RS24860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CXR04_RS24955	COG1113	amino acid transport
CXR04_RS24960	COG1268	BioY protein
CXR04_RS24970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR04_RS24975	COG2208	phosphoserine phosphatase activity
CXR04_RS24980	COG0475	glutathione-regulated potassium exporter activity
CXR04_RS24985	COG1136	(ABC) transporter
CXR04_RS24995	COG3594	Acyltransferase
CXR04_RS25015	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXR04_RS25020	COG0740	serine-type endopeptidase activity
CXR04_RS25025	COG0740	serine-type endopeptidase activity
CXR04_RS25030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXR04_RS25040	COG0525	valine-tRNA ligase activity
CXR04_RS25045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXR04_RS25050	COG0285	dihydrofolate synthase activity
CXR04_RS25060	COG0105	UTP biosynthetic process
CXR04_RS25065	COG1077	Cell shape determining protein MreB Mrl
CXR04_RS25080	COG0768	penicillin binding
CXR04_RS25085	COG0772	Belongs to the SEDS family
CXR04_RS25090	COG2259	Doxx family
CXR04_RS25135	COG1530	ribonuclease E activity
CXR04_RS25145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXR04_RS25150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXR04_RS25155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXR04_RS25165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXR04_RS25175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXR04_RS25190	COG0501	Belongs to the peptidase M48B family
CXR04_RS25200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXR04_RS25215	COG0588	phosphoglycerate mutase activity
CXR04_RS25230	COG0477	Major facilitator Superfamily
CXR04_RS25245	COG0495	leucyl-tRNA aminoacylation
CXR04_RS25255	COG1307	EDD domain protein, DegV family
CXR04_RS25260	COG1555	photosystem II stabilization
CXR04_RS25260	COG1596	polysaccharide export
CXR04_RS25270	COG2353	YceI-like domain
CXR04_RS25285	COG0268	Binds directly to 16S ribosomal RNA
CXR04_RS25290	COG0481	GTPase activity
CXR04_RS25295	COG1022	Amp-dependent synthetase and ligase
CXR04_RS25335	COG1420	regulation of RNA biosynthetic process
CXR04_RS25340	COG0484	heat shock protein binding
CXR04_RS25365	COG0537	adenosine 5'-monophosphoramidase activity
CXR04_RS25370	COG1234	tRNA 3'-trailer cleavage
CXR04_RS25400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXR04_RS25420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXR04_RS25430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXR04_RS25445	COG2409	Drug exporters of the RND superfamily
CXR04_RS25455	COG2197	response regulator
CXR04_RS25460	COG2186	Transcriptional regulator
CXR04_RS25470	COG1381	Involved in DNA repair and RecF pathway recombination
CXR04_RS25475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXR04_RS25485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CXR04_RS25490	COG1121	(ABC) transporter
CXR04_RS25495	COG3443	Belongs to the bacterial solute-binding protein 9 family
CXR04_RS25495	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXR04_RS25500	COG0423	glycine-tRNA ligase activity
CXR04_RS25515	COG0667	Aldo Keto reductase
CXR04_RS25535	COG0515	serine threonine protein kinase
CXR04_RS25535	COG2815	serine threonine protein kinase
CXR04_RS25595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CXR04_RS25615	COG0574	Belongs to the PEP-utilizing enzyme family
CXR04_RS25615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXR04_RS25625	COG0515	serine threonine protein kinase
CXR04_RS25625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS25640	COG0243	molybdopterin cofactor binding
CXR04_RS25660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXR04_RS25665	COG2146	nitrite reductase [NAD(P)H] activity
CXR04_RS25665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXR04_RS25675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CXR04_RS25690	COG4585	Histidine kinase
CXR04_RS25700	COG2197	response regulator
CXR04_RS25710	COG3135	benzoate transporter
CXR04_RS25715	COG2226	methyltransferase
CXR04_RS25730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR04_RS25785	COG0358	DNA primase activity
CXR04_RS25790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXR04_RS25810	COG1175	transmembrane transport
CXR04_RS25815	COG0395	ABC-type sugar transport system, permease component
CXR04_RS25820	COG0366	Alpha amylase catalytic
CXR04_RS25840	COG1070	Carbohydrate kinase
CXR04_RS25870	COG3209	COG3209 Rhs family protein
CXR04_RS25890	COG2706	6-phosphogluconolactonase activity
CXR04_RS25915	COG1595	DNA-templated transcription, initiation
CXR04_RS25935	COG1595	DNA-templated transcription, initiation
CXR04_RS25940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXR04_RS25945	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CXR04_RS26010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CXR04_RS26015	COG2814	Major facilitator Superfamily
CXR04_RS26045	COG1309	transcriptional regulator
CXR04_RS26075	COG2837	iron assimilation
CXR04_RS26115	COG1396	sequence-specific DNA binding
CXR04_RS26190	COG0604	alcohol dehydrogenase
CXR04_RS26210	COG1653	transport
CXR04_RS26225	COG0739	heme binding
CXR04_RS26225	COG1196	nuclear chromosome segregation
CXR04_RS26225	COG0741	lytic transglycosylase activity
CXR04_RS26230	COG2835	tetraacyldisaccharide 4'-kinase activity
CXR04_RS26250	COG4981	capsule polysaccharide biosynthetic process
CXR04_RS26280	COG1414	Transcriptional regulator
CXR04_RS26285	COG3386	PFAM SMP-30 Gluconolaconase
CXR04_RS26290	COG0667	Aldo Keto reductase
CXR04_RS26310	COG4214	carbohydrate transport
CXR04_RS26315	COG1129	ABC transporter
CXR04_RS26350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXR04_RS26355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR04_RS26360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR04_RS26380	COG1132	(ABC) transporter
CXR04_RS26430	COG0789	Transcriptional regulator
CXR04_RS26435	COG0667	Aldo Keto reductase
CXR04_RS26440	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXR04_RS26475	COG1358	cellular component organization or biogenesis
CXR04_RS26525	COG3629	intracellular signal transduction
CXR04_RS26530	COG1309	transcriptional regulator
CXR04_RS26540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR04_RS26545	COG2409	Drug exporters of the RND superfamily
CXR04_RS26560	COG1090	epimerase
CXR04_RS26595	COG1234	tRNA 3'-trailer cleavage
CXR04_RS26680	COG3226	Transcriptional regulator
CXR04_RS26685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR04_RS26725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXR04_RS26735	COG3845	ABC transporter
CXR04_RS26750	COG1657	PFAM Prenyltransferase squalene oxidase
CXR04_RS26765	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS26770	COG1309	transcriptional regulator
CXR04_RS26805	COG2030	dehydratase
CXR04_RS26815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CXR04_RS26840	COG0800	Aldolase
CXR04_RS26845	COG3022	response to hydroperoxide
CXR04_RS26885	COG1073	alpha beta
CXR04_RS26925	COG0076	glutamate decarboxylase activity
CXR04_RS26995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CXR04_RS27000	COG1793	dna ligase
CXR04_RS27000	COG3285	dna ligase
CXR04_RS27015	COG2346	COG2346, Truncated hemoglobins
CXR04_RS27025	COG3540	Alkaline phosphatase
CXR04_RS27035	COG0489	protein tyrosine kinase activity
CXR04_RS27040	COG0297	glycogen (starch) synthase activity
CXR04_RS27065	COG1834	amidinotransferase
CXR04_RS27080	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS27085	COG0463	Glycosyl transferase, family 2
CXR04_RS27100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CXR04_RS27105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXR04_RS27110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXR04_RS27120	COG0395	ABC-type sugar transport system, permease component
CXR04_RS27125	COG1175	transmembrane transport
CXR04_RS27135	COG1609	Transcriptional regulator
CXR04_RS27140	COG0667	Aldo Keto reductase
CXR04_RS27185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CXR04_RS27185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXR04_RS27215	COG0477	Major facilitator Superfamily
CXR04_RS27220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXR04_RS27265	COG3973	AAA domain
CXR04_RS27275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXR04_RS27280	COG0174	glutamine synthetase
CXR04_RS27295	COG2197	response regulator
CXR04_RS27300	COG4585	Histidine kinase
CXR04_RS27355	COG4106	trans-aconitate 2-methyltransferase activity
CXR04_RS27360	COG3835	regulator
CXR04_RS27365	COG2755	lipolytic protein G-D-S-L family
CXR04_RS27370	COG0583	DNA-binding transcription factor activity
CXR04_RS27395	COG0500	methyltransferase
CXR04_RS27400	COG0640	Transcriptional regulator
CXR04_RS27420	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS27420	COG0604	alcohol dehydrogenase
CXR04_RS27420	COG3321	synthase
CXR04_RS27430	COG0586	Pfam SNARE associated Golgi protein
CXR04_RS27435	COG0028	Belongs to the TPP enzyme family
CXR04_RS27435	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CXR04_RS27445	COG0477	Major facilitator Superfamily
CXR04_RS27450	COG0504	CTP synthase activity
CXR04_RS27455	COG3383	formate dehydrogenase (NAD+) activity
CXR04_RS27460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXR04_RS27465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CXR04_RS27480	COG0573	inorganic phosphate transmembrane transporter activity
CXR04_RS27485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXR04_RS27490	COG0640	Transcriptional regulator
CXR04_RS27495	COG0640	Transcriptional regulator
CXR04_RS27510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXR04_RS27520	COG0798	PFAM Bile acid sodium symporter
CXR04_RS27545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXR04_RS27550	COG0321	lipoyl(octanoyl) transferase activity
CXR04_RS27580	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS27590	COG0733	neurotransmitter:sodium symporter activity
CXR04_RS27600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CXR04_RS27620	COG2319	Wd-40 repeat
CXR04_RS27620	COG4249	Peptidase C14 caspase catalytic subunit p20
CXR04_RS27625	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR04_RS27630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXR04_RS27635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXR04_RS27640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CXR04_RS27645	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CXR04_RS27675	COG4585	Histidine kinase
CXR04_RS27690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CXR04_RS27710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXR04_RS27715	COG1104	cysteine desulfurase activity
CXR04_RS27720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXR04_RS27725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXR04_RS27735	COG1376	ErfK ybiS ycfS ynhG family protein
CXR04_RS27745	COG1845	cytochrome c oxidase, subunit III
CXR04_RS27750	COG2010	Cytochrome c
CXR04_RS27755	COG0723	plastoquinol--plastocyanin reductase activity
CXR04_RS27760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXR04_RS27765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXR04_RS27775	COG1929	Belongs to the glycerate kinase type-1 family
CXR04_RS27785	COG0745	RESPONSE REGULATOR receiver
CXR04_RS27790	COG2205	protein histidine kinase activity
CXR04_RS27835	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS27855	COG0003	Pfam Anion-transporting ATPase
CXR04_RS27865	COG1940	carbohydrate kinase activity
CXR04_RS27905	COG2197	response regulator
CXR04_RS27910	COG0205	6-phosphofructokinase activity
CXR04_RS27925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CXR04_RS27930	COG0243	molybdopterin cofactor binding
CXR04_RS27935	COG2193	ferroxidase activity
CXR04_RS27940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXR04_RS27945	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CXR04_RS27950	COG0515	serine threonine protein kinase
CXR04_RS27950	COG2815	serine threonine protein kinase
CXR04_RS27955	COG2022	thiamine diphosphate biosynthetic process
CXR04_RS27965	COG2022	thiamine diphosphate biosynthetic process
CXR04_RS27965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXR04_RS27980	COG0352	thiamine-phosphate diphosphorylase activity
CXR04_RS28025	COG0714	Associated with various cellular activities
CXR04_RS28035	COG0275	rRNA processing
CXR04_RS28045	COG0768	penicillin binding
CXR04_RS28050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXR04_RS28060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXR04_RS28065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXR04_RS28075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXR04_RS28080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CXR04_RS28085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CXR04_RS28090	COG1496	oxidoreductase activity
CXR04_RS28095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CXR04_RS28100	COG1799	cell septum assembly
CXR04_RS28115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXR04_RS28125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXR04_RS28160	COG0587	DNA-directed DNA polymerase activity
CXR04_RS28195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXR04_RS28210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXR04_RS28215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXR04_RS28220	COG0131	Imidazoleglycerol-phosphate dehydratase
CXR04_RS28225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXR04_RS28230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXR04_RS28235	COG0251	oxidation-reduction process
CXR04_RS28240	COG0107	imidazoleglycerol-phosphate synthase activity
CXR04_RS28255	COG0183	Belongs to the thiolase family
CXR04_RS28280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR04_RS28285	COG5297	Belongs to the glycosyl hydrolase family 6
CXR04_RS28285	COG4733	cellulase activity
CXR04_RS28290	COG5297	Belongs to the glycosyl hydrolase family 6
CXR04_RS28305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXR04_RS28310	COG1053	succinate dehydrogenase
CXR04_RS28325	COG1472	Belongs to the glycosyl hydrolase 3 family
CXR04_RS28340	COG0745	RESPONSE REGULATOR receiver
CXR04_RS28365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXR04_RS28370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CXR04_RS28390	COG0134	indole-3-glycerol-phosphate synthase activity
CXR04_RS28400	COG0133	tryptophan synthase activity
CXR04_RS28405	COG0159	tryptophan synthase activity
CXR04_RS28420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXR04_RS28430	COG0067	glutamate synthase
CXR04_RS28430	COG0069	glutamate synthase activity
CXR04_RS28430	COG0070	glutamate synthase
CXR04_RS28445	COG1653	transport
CXR04_RS28450	COG1175	transmembrane transport
CXR04_RS28455	COG0395	ABC-type sugar transport system, permease component
CXR04_RS28465	COG3467	pyridoxamine 5'-phosphate
CXR04_RS28480	COG2197	response regulator
CXR04_RS28485	COG4585	Histidine kinase
CXR04_RS28500	COG0697	spore germination
CXR04_RS28505	COG0287	Prephenate dehydrogenase
CXR04_RS28505	COG1605	Chorismate mutase
CXR04_RS28550	COG2050	protein possibly involved in aromatic compounds catabolism
CXR04_RS28565	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS28570	COG0529	Catalyzes the synthesis of activated sulfate
CXR04_RS28635	COG1643	Atp-dependent helicase
CXR04_RS28640	COG2226	methyltransferase
CXR04_RS28645	COG0539	negative regulation of cytoplasmic translation
CXR04_RS28650	COG4585	Histidine kinase
CXR04_RS28655	COG2197	response regulator
CXR04_RS28660	COG2409	Drug exporters of the RND superfamily
CXR04_RS28675	COG0237	dephospho-CoA kinase activity
CXR04_RS28740	COG2313	pseudouridylate synthase activity
CXR04_RS28760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXR04_RS28770	COG0584	glycerophosphoryl diester phosphodiesterase
CXR04_RS28775	COG0556	nucleotide-excision repair
CXR04_RS28805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXR04_RS28815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXR04_RS28815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CXR04_RS28820	COG0322	excinuclease ABC activity
CXR04_RS28825	COG1660	Displays ATPase and GTPase activities
CXR04_RS28830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CXR04_RS28835	COG1481	regulation of sporulation
CXR04_RS28845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXR04_RS28850	COG0126	phosphoglycerate kinase activity
CXR04_RS28855	COG0149	triose-phosphate isomerase activity
CXR04_RS28860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXR04_RS28875	COG0166	Belongs to the GPI family
CXR04_RS28885	COG4821	SIS domain
CXR04_RS28895	COG0363	glucosamine-6-phosphate deaminase activity
CXR04_RS28910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXR04_RS28920	COG0109	protoheme IX farnesyltransferase activity
CXR04_RS28930	COG1612	heme a metabolic process
CXR04_RS28940	COG1131	(ABC) transporter
CXR04_RS28955	COG0719	Fe-S assembly protein
CXR04_RS28965	COG0396	ATPase activity
CXR04_RS28970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXR04_RS28975	COG0822	iron-sulfur transferase activity
CXR04_RS28980	COG2151	metal-sulfur cluster biosynthetic enzyme
CXR04_RS28995	COG2171	N-acyltransferase activity
CXR04_RS29040	COG3866	Pectate lyase
CXR04_RS29045	COG2252	PERMEase
CXR04_RS29065	COG1185	polyribonucleotide nucleotidyltransferase activity
CXR04_RS29075	COG2197	response regulator
CXR04_RS29080	COG4585	Histidine kinase
CXR04_RS29090	COG1414	Transcriptional regulator
CXR04_RS29140	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CXR04_RS29155	COG1797	cobyrinic acid a,c-diamide synthase activity
CXR04_RS29160	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CXR04_RS29175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CXR04_RS29200	COG5285	phytanoyl-CoA dioxygenase
CXR04_RS29205	COG1917	Cupin 2, conserved barrel domain protein
CXR04_RS29215	COG0456	acetyltransferase
CXR04_RS29230	COG1492	cobalamin metabolic process
CXR04_RS29245	COG0235	Class ii aldolase
CXR04_RS29265	COG0488	(ABC) transporter
CXR04_RS29275	COG1024	Enoyl-CoA hydratase
CXR04_RS29325	COG2197	response regulator
CXR04_RS29330	COG4585	Histidine kinase
CXR04_RS29340	COG0583	DNA-binding transcription factor activity
CXR04_RS29355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXR04_RS29375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXR04_RS29390	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS29405	COG2186	Transcriptional regulator
CXR04_RS29410	COG2807	transmembrane transport
CXR04_RS29425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXR04_RS29435	COG3830	Belongs to the UPF0237 family
CXR04_RS29435	COG0560	Phosphoserine phosphatase
CXR04_RS29440	COG0842	Transport permease protein
CXR04_RS29440	COG1716	ATPase activity
CXR04_RS29440	COG1131	(ABC) transporter
CXR04_RS29450	COG2197	response regulator
CXR04_RS29470	COG1119	ATPase activity
CXR04_RS29490	COG1881	PFAM PEBP family protein
CXR04_RS29500	COG2094	Belongs to the DNA glycosylase MPG family
CXR04_RS29535	COG0647	UMP catabolic process
CXR04_RS29540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR04_RS29545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXR04_RS29550	COG1120	ATPase activity
CXR04_RS29560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXR04_RS29565	COG0497	DNA recombination
CXR04_RS29575	COG3387	PFAM Glycoside hydrolase 15-related
CXR04_RS29580	COG0504	CTP synthase activity
CXR04_RS29585	COG0494	nUDIX hydrolase
CXR04_RS29595	COG0686	Belongs to the AlaDH PNT family
CXR04_RS29615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXR04_RS29620	COG1187	pseudouridine synthase activity
CXR04_RS29630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXR04_RS29640	COG1160	GTP binding
CXR04_RS29655	COG1652	LysM domain
CXR04_RS29685	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS29690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXR04_RS29700	COG0671	phosphoesterase, PA-phosphatase related
CXR04_RS29705	COG0477	Major facilitator Superfamily
CXR04_RS29710	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS29715	COG1799	cell septum assembly
CXR04_RS29725	COG0330	HflC and HflK could
CXR04_RS29730	COG0529	Catalyzes the synthesis of activated sulfate
CXR04_RS29735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CXR04_RS29740	COG0531	amino acid
CXR04_RS29750	COG2910	NAD(P)H-binding
CXR04_RS29780	COG4585	Histidine kinase
CXR04_RS29785	COG2197	response regulator
CXR04_RS29795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CXR04_RS29800	COG0587	DNA-directed DNA polymerase activity
CXR04_RS29805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CXR04_RS29810	COG0318	PFAM AMP-dependent synthetase and ligase
CXR04_RS29825	COG1834	amidinotransferase
CXR04_RS29830	COG3903	Transcriptional regulator
CXR04_RS29830	COG3629	intracellular signal transduction
CXR04_RS29845	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXR04_RS29845	COG3409	Peptidoglycan-binding domain 1 protein
CXR04_RS29860	COG1725	Transcriptional regulator
CXR04_RS29905	COG2188	Transcriptional regulator
CXR04_RS29910	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CXR04_RS29925	COG3507	Belongs to the glycosyl hydrolase 43 family
CXR04_RS29940	COG0154	amidase activity
CXR04_RS29980	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS29990	COG3265	gluconokinase activity
CXR04_RS30000	COG2149	membrane
CXR04_RS30010	COG2223	nitrite transmembrane transporter activity
CXR04_RS30020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR04_RS30025	COG4608	Belongs to the ABC transporter superfamily
CXR04_RS30030	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS30040	COG0747	negative chemotaxis
CXR04_RS30060	COG0183	Belongs to the thiolase family
CXR04_RS30065	COG0028	Belongs to the TPP enzyme family
CXR04_RS30070	COG3119	arylsulfatase activity
CXR04_RS30085	COG2124	cytochrome p450
CXR04_RS30085	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXR04_RS30100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXR04_RS30110	COG0596	Alpha beta hydrolase
CXR04_RS30110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXR04_RS30110	COG2226	methyltransferase
CXR04_RS30155	COG0604	alcohol dehydrogenase
CXR04_RS30165	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS30170	COG2140	Oxalate decarboxylase
CXR04_RS30175	COG1914	H( )-stimulated, divalent metal cation uptake system
CXR04_RS30200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXR04_RS30230	COG3708	Transcriptional regulator
CXR04_RS30230	COG2207	Transcriptional regulator
CXR04_RS30240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXR04_RS30270	COG0667	Aldo Keto reductase
CXR04_RS30275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXR04_RS30285	COG0598	Magnesium transport protein CorA
CXR04_RS30305	COG0215	cysteine-tRNA ligase activity
CXR04_RS30315	COG4948	Mandelate Racemase Muconate Lactonizing
CXR04_RS30325	COG1129	ABC transporter
CXR04_RS30330	COG4211	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS30345	COG2186	Transcriptional regulator
CXR04_RS30350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CXR04_RS30355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR04_RS30360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CXR04_RS30365	COG1414	Transcriptional regulator
CXR04_RS30370	COG0646	methionine synthase
CXR04_RS30370	COG1410	methionine synthase
CXR04_RS30380	COG0747	negative chemotaxis
CXR04_RS30385	COG0747	negative chemotaxis
CXR04_RS30390	COG2197	response regulator
CXR04_RS30400	COG0517	IMP dehydrogenase activity
CXR04_RS30400	COG1994	Peptidase M50
CXR04_RS30415	COG1222	aaa ATPase
CXR04_RS30420	COG4122	O-methyltransferase activity
CXR04_RS30430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR04_RS30435	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR04_RS30440	COG1609	Transcriptional regulator
CXR04_RS30450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CXR04_RS30455	COG1047	Peptidyl-prolyl cis-trans
CXR04_RS30480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXR04_RS30485	COG0805	protein transport
CXR04_RS30530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR04_RS30535	COG4175	Glycine betaine
CXR04_RS30535	COG0517	IMP dehydrogenase activity
CXR04_RS30565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CXR04_RS30570	COG1113	amino acid transport
CXR04_RS30585	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS30625	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXR04_RS30630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXR04_RS30635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXR04_RS30640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXR04_RS30645	COG5002	protein histidine kinase activity
CXR04_RS30650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXR04_RS30655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXR04_RS30655	COG0072	phenylalanine-tRNA ligase activity
CXR04_RS30665	COG1649	PFAM Uncharacterised BCR, COG1649
CXR04_RS30690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXR04_RS30695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXR04_RS30700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXR04_RS30705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXR04_RS30710	COG1438	arginine binding
CXR04_RS30715	COG2076	Multidrug Resistance protein
CXR04_RS30725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXR04_RS30735	COG0473	3-isopropylmalate dehydrogenase activity
CXR04_RS30740	COG0471	metal ion transport
CXR04_RS30745	COG0137	argininosuccinate synthase activity
CXR04_RS30750	COG0165	Argininosuccinate lyase
CXR04_RS30765	COG0714	Associated with various cellular activities
CXR04_RS30775	COG2304	oxidoreductase activity
CXR04_RS30780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXR04_RS30785	COG0745	RESPONSE REGULATOR receiver
CXR04_RS30790	COG2205	protein histidine kinase activity
CXR04_RS30795	COG0204	Acyl-transferase
CXR04_RS30795	COG0318	PFAM AMP-dependent synthetase and ligase
CXR04_RS30800	COG0584	glycerophosphoryl diester phosphodiesterase
CXR04_RS30825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXR04_RS30830	COG2011	ABC-type metal ion transport system permease component
CXR04_RS30845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CXR04_RS30850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXR04_RS30850	COG1648	precorrin-2 dehydrogenase activity
CXR04_RS30895	COG4552	Acetyltransferase involved in intracellular survival and related
CXR04_RS30915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CXR04_RS30955	COG5002	protein histidine kinase activity
CXR04_RS30955	COG2176	DNA-directed DNA polymerase activity
CXR04_RS30965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXR04_RS30980	COG0626	cystathionine gamma-synthase activity
CXR04_RS30985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXR04_RS31000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CXR04_RS31005	COG1560	Kdo2-lipid A biosynthetic process
CXR04_RS31010	COG0438	transferase activity, transferring glycosyl groups
CXR04_RS31020	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CXR04_RS31025	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CXR04_RS31030	COG0217	transcriptional regulatory protein
CXR04_RS31035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXR04_RS31040	COG0632	four-way junction helicase activity
CXR04_RS31045	COG2255	four-way junction helicase activity
CXR04_RS31055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR04_RS31060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXR04_RS31065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CXR04_RS31070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXR04_RS31075	COG1196	nuclear chromosome segregation
CXR04_RS31080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CXR04_RS31090	COG0124	histidyl-tRNA synthetase
CXR04_RS31105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXR04_RS31120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXR04_RS31125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXR04_RS31135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXR04_RS31140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXR04_RS31145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXR04_RS31150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXR04_RS31155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXR04_RS31160	COG0515	serine threonine protein kinase
CXR04_RS31160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXR04_RS31180	COG0006	proline dipeptidase activity
CXR04_RS31185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXR04_RS31190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXR04_RS31200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CXR04_RS31205	COG0540	Belongs to the ATCase OTCase family
CXR04_RS31210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR04_RS31220	COG0505	Belongs to the CarA family
CXR04_RS31225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXR04_RS31230	COG0167	dihydroorotate dehydrogenase activity
CXR04_RS31235	COG0284	orotidine-5'-phosphate decarboxylase activity
CXR04_RS31245	COG0194	GDP metabolic process
CXR04_RS31260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXR04_RS31275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXR04_RS31285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXR04_RS31290	COG2390	Transcriptional regulator
CXR04_RS31300	COG3594	Acyltransferase
CXR04_RS31305	COG2814	Major facilitator Superfamily
CXR04_RS31310	COG4948	Mandelate Racemase Muconate Lactonizing
CXR04_RS31315	COG0395	ABC-type sugar transport system, permease component
CXR04_RS31320	COG1175	transmembrane transport
CXR04_RS31335	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS31340	COG2186	Transcriptional regulator
CXR04_RS31385	COG0668	transmembrane transport
CXR04_RS31390	COG2197	response regulator
CXR04_RS31425	COG0277	FAD linked oxidase domain protein
CXR04_RS31445	COG1012	belongs to the aldehyde dehydrogenase family
CXR04_RS31460	COG0045	succinate-CoA ligase (ADP-forming) activity
CXR04_RS31470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR04_RS31480	COG2223	nitrite transmembrane transporter activity
CXR04_RS31490	COG0303	'Molybdopterin
CXR04_RS31495	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CXR04_RS31500	COG3383	formate dehydrogenase (NAD+) activity
CXR04_RS31515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXR04_RS31530	COG1606	tRNA processing
CXR04_RS31535	COG1691	(AIR) carboxylase
CXR04_RS31540	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CXR04_RS31550	COG1063	alcohol dehydrogenase
CXR04_RS31565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR04_RS31565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXR04_RS31590	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
CXR04_RS31610	COG2723	6-phospho-beta-galactosidase activity
CXR04_RS31615	COG0395	ABC-type sugar transport system, permease component
CXR04_RS31630	COG1940	carbohydrate kinase activity
CXR04_RS31660	COG0531	amino acid
CXR04_RS31670	COG2409	Drug exporters of the RND superfamily
CXR04_RS31720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXR04_RS31725	COG3360	Dodecin
CXR04_RS31770	COG5183	chlorophyll binding
CXR04_RS31770	COG2133	pyrroloquinoline quinone binding
CXR04_RS31775	COG1609	Transcriptional regulator
CXR04_RS31780	COG1879	ABC-type sugar transport system periplasmic component
CXR04_RS31785	COG1129	ABC transporter
CXR04_RS31790	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS31795	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS31805	COG1316	TRANSCRIPTIONal
CXR04_RS31815	COG0601	transmembrane transport
CXR04_RS31820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CXR04_RS31825	COG0444	Belongs to the ABC transporter superfamily
CXR04_RS31830	COG1124	(ABC) transporter
CXR04_RS31845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXR04_RS31855	COG1175	transmembrane transport
CXR04_RS31860	COG0395	ABC-type sugar transport system, permease component
CXR04_RS31885	COG1414	Transcriptional regulator
CXR04_RS31900	COG0395	ABC-type sugar transport system, permease component
CXR04_RS31905	COG1175	transmembrane transport
CXR04_RS31935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXR04_RS31940	COG4948	Mandelate Racemase Muconate Lactonizing
CXR04_RS31950	COG1940	carbohydrate kinase activity
CXR04_RS31955	COG2610	gluconate transmembrane transporter activity
CXR04_RS31960	COG3395	kinase activity
CXR04_RS31965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXR04_RS31970	COG1349	DNA-binding transcription factor activity
CXR04_RS31975	COG1070	Carbohydrate kinase
CXR04_RS31980	COG2115	Belongs to the xylose isomerase family
CXR04_RS32000	COG0765	amino acid transport
CXR04_RS32015	COG0372	Belongs to the citrate synthase family
CXR04_RS32025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXR04_RS32085	COG1132	(ABC) transporter
CXR04_RS32090	COG1132	(ABC) transporter
CXR04_RS32115	COG1132	(ABC) transporter
CXR04_RS32120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CXR04_RS32140	COG1404	Belongs to the peptidase S8 family
CXR04_RS32170	COG3876	Protein conserved in bacteria
CXR04_RS32175	COG1556	Lactate utilization protein
CXR04_RS32180	COG1139	Iron-sulfur cluster binding protein
CXR04_RS32185	COG0247	lactate metabolic process
CXR04_RS32190	COG1070	Carbohydrate kinase
CXR04_RS32195	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS32195	COG3347	Dehydrogenase
CXR04_RS32205	COG3250	beta-galactosidase activity
CXR04_RS32210	COG1129	ABC transporter
CXR04_RS32220	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS32225	COG1879	ABC-type sugar transport system periplasmic component
CXR04_RS32230	COG3254	rhamnose metabolic process
CXR04_RS32245	COG1609	Transcriptional regulator
CXR04_RS32250	COG2072	flavoprotein involved in K transport
CXR04_RS32275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXR04_RS32300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXR04_RS32320	COG1309	transcriptional regulator
CXR04_RS32345	COG0671	phosphoesterase, PA-phosphatase related
CXR04_RS32360	COG0584	glycerophosphoryl diester phosphodiesterase
CXR04_RS32405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CXR04_RS32450	COG3345	alpha-galactosidase
CXR04_RS32460	COG1175	transmembrane transport
CXR04_RS32465	COG0395	ABC-type sugar transport system, permease component
CXR04_RS32470	COG0494	nUDIX hydrolase
CXR04_RS32490	COG0445	tRNA wobble uridine modification
CXR04_RS32505	COG4585	Histidine kinase
CXR04_RS32510	COG2197	response regulator
CXR04_RS32520	COG2201	protein-glutamate methylesterase activity
CXR04_RS32570	COG1051	belongs to the nudix hydrolase family
CXR04_RS32585	COG1136	(ABC) transporter
CXR04_RS32590	COG0577	efflux transmembrane transporter activity
CXR04_RS32605	COG1349	DNA-binding transcription factor activity
CXR04_RS32615	COG0464	growth
CXR04_RS32630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXR04_RS32645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CXR04_RS32655	COG1461	Dihydroxyacetone kinase
CXR04_RS32660	COG2376	Dihydroxyacetone kinase
CXR04_RS32675	COG0515	serine threonine protein kinase
CXR04_RS32685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXR04_RS32805	COG2018	Roadblock/LC7 domain
CXR04_RS32810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR04_RS32815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CXR04_RS32830	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CXR04_RS32840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXR04_RS32850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXR04_RS32865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXR04_RS32905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CXR04_RS32915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXR04_RS32915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXR04_RS33045	COG0318	PFAM AMP-dependent synthetase and ligase
CXR04_RS33050	COG0583	DNA-binding transcription factor activity
CXR04_RS33060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXR04_RS33065	COG2610	gluconate transmembrane transporter activity
CXR04_RS33070	COG1609	Transcriptional regulator
CXR04_RS33075	COG3537	Alpha-1,2-mannosidase
CXR04_RS33080	COG3537	Alpha-1,2-mannosidase
CXR04_RS33105	COG1404	Belongs to the peptidase S8 family
CXR04_RS33115	COG0673	inositol 2-dehydrogenase activity
CXR04_RS33120	COG2186	Transcriptional regulator
CXR04_RS33125	COG0395	ABC-type sugar transport system, permease component
CXR04_RS33130	COG1175	transmembrane transport
CXR04_RS33135	COG1653	transport
CXR04_RS33155	COG2197	response regulator
CXR04_RS33160	COG4585	Histidine kinase
CXR04_RS33190	COG1162	GTPase activity
CXR04_RS33220	COG3321	synthase
CXR04_RS33220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR04_RS33220	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS33220	COG4221	oxidoreductase activity
CXR04_RS33225	COG3321	synthase
CXR04_RS33225	COG0604	alcohol dehydrogenase
CXR04_RS33240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR04_RS33260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR04_RS33265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXR04_RS33285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR04_RS33350	COG2267	carboxylic ester hydrolase activity
CXR04_RS33355	COG0596	Alpha beta hydrolase
CXR04_RS33395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXR04_RS33425	COG1968	undecaprenyl-diphosphatase activity
CXR04_RS33440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXR04_RS33470	COG0110	maltose O-acetyltransferase activity
CXR04_RS33490	COG1832	CoA-binding protein
CXR04_RS33495	COG1739	Uncharacterized protein family UPF0029
CXR04_RS33500	COG0420	3'-5' exonuclease activity
CXR04_RS33505	COG0419	ATPase involved in DNA repair
CXR04_RS33520	COG0626	cystathionine gamma-synthase activity
CXR04_RS33540	COG1595	DNA-templated transcription, initiation
CXR04_RS33545	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS33550	COG2188	Transcriptional regulator
CXR04_RS33555	COG1940	carbohydrate kinase activity
CXR04_RS33560	COG2197	response regulator
CXR04_RS33565	COG4585	Histidine kinase
CXR04_RS33570	COG1131	(ABC) transporter
CXR04_RS33580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CXR04_RS33605	COG1136	(ABC) transporter
CXR04_RS33605	COG0577	efflux transmembrane transporter activity
CXR04_RS33610	COG1136	(ABC) transporter
CXR04_RS33615	COG2226	methyltransferase
CXR04_RS33620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXR04_RS33625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXR04_RS33630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXR04_RS33640	COG2801	Transposase and inactivated derivatives
CXR04_RS33640	COG3415	Transposase
CXR04_RS33680	COG0740	serine-type endopeptidase activity
CXR04_RS33690	COG2814	Major facilitator Superfamily
CXR04_RS33695	COG3795	YCII-related domain
CXR04_RS33700	COG4941	Belongs to the sigma-70 factor family
CXR04_RS33710	COG2409	Drug exporters of the RND superfamily
CXR04_RS33730	COG2814	Major facilitator Superfamily
CXR04_RS33740	COG0204	Acyl-transferase
CXR04_RS33745	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS33760	COG3442	glutamine amidotransferase
CXR04_RS33790	COG2197	response regulator
CXR04_RS33820	COG3469	chitinase activity
CXR04_RS33835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXR04_RS33845	COG1309	transcriptional regulator
CXR04_RS33850	COG0318	PFAM AMP-dependent synthetase and ligase
CXR04_RS33855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXR04_RS33855	COG0300	oxidoreductase activity
CXR04_RS33855	COG3321	synthase
CXR04_RS33855	COG4221	oxidoreductase activity
CXR04_RS33880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXR04_RS33950	COG3321	synthase
CXR04_RS33950	COG0604	alcohol dehydrogenase
CXR04_RS33970	COG0604	alcohol dehydrogenase
CXR04_RS33970	COG3321	synthase
CXR04_RS33980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CXR04_RS34005	COG0586	Pfam SNARE associated Golgi protein
CXR04_RS34015	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXR04_RS34030	COG2197	response regulator
CXR04_RS34095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXR04_RS34100	COG1960	acyl-CoA dehydrogenase activity
CXR04_RS34110	COG0134	indole-3-glycerol-phosphate synthase activity
CXR04_RS34120	COG2080	2 iron, 2 sulfur cluster binding
CXR04_RS34125	COG0251	oxidation-reduction process
CXR04_RS34130	COG1733	regulation of RNA biosynthetic process
CXR04_RS34150	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CXR04_RS34170	COG1028	Short-chain dehydrogenase reductase Sdr
CXR04_RS34185	COG0579	oxidoreductase
CXR04_RS34190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXR04_RS34195	COG0531	amino acid
CXR04_RS34200	COG1349	DNA-binding transcription factor activity
CXR04_RS34220	COG0515	serine threonine protein kinase
CXR04_RS34235	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS34255	COG0402	S-adenosylhomocysteine deaminase activity
CXR04_RS34260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXR04_RS34265	COG0252	asparaginase activity
CXR04_RS34275	COG2801	Transposase and inactivated derivatives
CXR04_RS34275	COG3415	Transposase
CXR04_RS34280	COG3119	arylsulfatase activity
CXR04_RS34300	COG2267	carboxylic ester hydrolase activity
CXR04_RS34350	COG0673	inositol 2-dehydrogenase activity
CXR04_RS34370	COG1653	transport
CXR04_RS34375	COG1349	DNA-binding transcription factor activity
CXR04_RS34390	COG1609	Transcriptional regulator
CXR04_RS34400	COG1172	Belongs to the binding-protein-dependent transport system permease family
CXR04_RS34430	COG0384	phenazine biosynthesis protein PhzF
CXR04_RS34435	COG0395	ABC-type sugar transport system, permease component
CXR04_RS34440	COG1175	transmembrane transport
CXR04_RS34460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXR04_RS34465	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CXR04_RS34470	COG2080	2 iron, 2 sulfur cluster binding
CXR04_RS34490	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CXR04_RS34515	COG0789	Transcriptional regulator
CXR04_RS34520	COG1819	glycosyl
CXR04_RS34530	COG1309	transcriptional regulator