locus-tag	class	description
AA958_RS00110	COG0395	ABC-type sugar transport system, permease component
AA958_RS00115	COG1175	transmembrane transport
AA958_RS00125	COG0445	tRNA wobble uridine modification
AA958_RS00270	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA958_RS00300	COG1397	ADP-ribosylglycohydrolase
AA958_RS00310	COG0831	urea catabolic process
AA958_RS00315	COG0832	Belongs to the urease beta subunit family
AA958_RS00320	COG0804	urea catabolic process
AA958_RS00330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA958_RS00335	COG0829	nickel cation binding
AA958_RS00345	COG1349	DNA-binding transcription factor activity
AA958_RS00350	COG1653	transport
AA958_RS00370	COG0673	inositol 2-dehydrogenase activity
AA958_RS00390	COG2423	ornithine cyclodeaminase activity
AA958_RS00400	COG0252	asparaginase activity
AA958_RS00405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA958_RS00410	COG0402	S-adenosylhomocysteine deaminase activity
AA958_RS00445	COG0515	serine threonine protein kinase
AA958_RS00445	COG2815	serine threonine protein kinase
AA958_RS00460	COG1349	DNA-binding transcription factor activity
AA958_RS00470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA958_RS00475	COG0579	oxidoreductase
AA958_RS00495	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AA958_RS00520	COG0251	oxidation-reduction process
AA958_RS00525	COG2080	2 iron, 2 sulfur cluster binding
AA958_RS00530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA958_RS00530	COG2010	Cytochrome c
AA958_RS00535	COG0134	indole-3-glycerol-phosphate synthase activity
AA958_RS00610	COG2197	response regulator
AA958_RS00625	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA958_RS00635	COG0586	Pfam SNARE associated Golgi protein
AA958_RS00660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA958_RS00670	COG0604	alcohol dehydrogenase
AA958_RS00670	COG3321	synthase
AA958_RS00675	COG3321	synthase
AA958_RS00675	COG0604	alcohol dehydrogenase
AA958_RS00680	COG3321	synthase
AA958_RS00680	COG0604	alcohol dehydrogenase
AA958_RS00700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA958_RS00725	COG4221	oxidoreductase activity
AA958_RS00725	COG3321	synthase
AA958_RS00725	COG0300	oxidoreductase activity
AA958_RS00725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA958_RS00730	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS00735	COG1309	transcriptional regulator
AA958_RS00745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA958_RS00780	COG2197	response regulator
AA958_RS00790	COG1609	Transcriptional regulator
AA958_RS00815	COG3442	glutamine amidotransferase
AA958_RS00830	COG1960	acyl-CoA dehydrogenase activity
AA958_RS00835	COG0204	Acyl-transferase
AA958_RS00855	COG4585	Histidine kinase
AA958_RS00860	COG2409	Drug exporters of the RND superfamily
AA958_RS00870	COG4941	Belongs to the sigma-70 factor family
AA958_RS00885	COG0740	serine-type endopeptidase activity
AA958_RS00930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA958_RS00935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA958_RS00940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AA958_RS00945	COG2226	methyltransferase
AA958_RS00950	COG1136	(ABC) transporter
AA958_RS00955	COG1136	(ABC) transporter
AA958_RS00955	COG0577	efflux transmembrane transporter activity
AA958_RS00960	COG0456	acetyltransferase
AA958_RS00980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA958_RS00990	COG1131	(ABC) transporter
AA958_RS00995	COG4585	Histidine kinase
AA958_RS01000	COG2197	response regulator
AA958_RS01005	COG1940	carbohydrate kinase activity
AA958_RS01010	COG2188	Transcriptional regulator
AA958_RS01015	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS01020	COG1595	DNA-templated transcription, initiation
AA958_RS01040	COG1902	pentaerythritol trinitrate reductase activity
AA958_RS01070	COG1309	transcriptional regulator
AA958_RS01115	COG0626	cystathionine gamma-synthase activity
AA958_RS01130	COG0419	ATPase involved in DNA repair
AA958_RS01135	COG0420	3'-5' exonuclease activity
AA958_RS01140	COG1739	Uncharacterized protein family UPF0029
AA958_RS01145	COG1832	CoA-binding protein
AA958_RS01165	COG0110	maltose O-acetyltransferase activity
AA958_RS01195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA958_RS01210	COG1968	undecaprenyl-diphosphatase activity
AA958_RS01235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AA958_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS01265	COG3119	arylsulfatase activity
AA958_RS01275	COG1309	transcriptional regulator
AA958_RS01290	COG0515	serine threonine protein kinase
AA958_RS01290	COG2815	serine threonine protein kinase
AA958_RS01315	COG0366	Alpha amylase catalytic
AA958_RS01320	COG3119	arylsulfatase activity
AA958_RS01345	COG1175	transmembrane transport
AA958_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS01380	COG3537	Alpha-1,2-mannosidase
AA958_RS01385	COG3537	Alpha-1,2-mannosidase
AA958_RS01390	COG1609	Transcriptional regulator
AA958_RS01395	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS01415	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA958_RS01460	COG0583	DNA-binding transcription factor activity
AA958_RS01525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA958_RS01525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA958_RS01535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA958_RS01575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA958_RS01590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA958_RS01600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA958_RS01615	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AA958_RS01625	COG0564	pseudouridine synthase activity
AA958_RS01630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AA958_RS01635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA958_RS01640	COG2018	Roadblock/LC7 domain
AA958_RS01745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA958_RS01755	COG0515	serine threonine protein kinase
AA958_RS01770	COG2376	Dihydroxyacetone kinase
AA958_RS01775	COG1461	Dihydroxyacetone kinase
AA958_RS01785	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA958_RS01800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA958_RS01815	COG0464	growth
AA958_RS01825	COG1349	DNA-binding transcription factor activity
AA958_RS01840	COG0577	efflux transmembrane transporter activity
AA958_RS01845	COG1136	(ABC) transporter
AA958_RS01860	COG1051	belongs to the nudix hydrolase family
AA958_RS01910	COG2201	protein-glutamate methylesterase activity
AA958_RS01920	COG2197	response regulator
AA958_RS01925	COG4585	Histidine kinase
AA958_RS01930	COG0445	tRNA wobble uridine modification
AA958_RS01950	COG0494	nUDIX hydrolase
AA958_RS01955	COG0395	ABC-type sugar transport system, permease component
AA958_RS01960	COG1175	transmembrane transport
AA958_RS01970	COG3345	alpha-galactosidase
AA958_RS01995	COG2814	Major facilitator Superfamily
AA958_RS02010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AA958_RS02055	COG0584	glycerophosphoryl diester phosphodiesterase
AA958_RS02070	COG0671	phosphoesterase, PA-phosphatase related
AA958_RS02095	COG1309	transcriptional regulator
AA958_RS02115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AA958_RS02140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA958_RS02170	COG2072	flavoprotein involved in K transport
AA958_RS02175	COG1609	Transcriptional regulator
AA958_RS02190	COG3254	rhamnose metabolic process
AA958_RS02195	COG1879	ABC-type sugar transport system periplasmic component
AA958_RS02200	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA958_RS02210	COG1129	ABC transporter
AA958_RS02215	COG3250	beta-galactosidase activity
AA958_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS02225	COG3347	Dehydrogenase
AA958_RS02230	COG1070	Carbohydrate kinase
AA958_RS02235	COG0247	lactate metabolic process
AA958_RS02240	COG1139	Iron-sulfur cluster binding protein
AA958_RS02245	COG1556	Lactate utilization protein
AA958_RS02250	COG3876	Protein conserved in bacteria
AA958_RS02280	COG1404	Belongs to the peptidase S8 family
AA958_RS02305	COG1132	(ABC) transporter
AA958_RS02330	COG1132	(ABC) transporter
AA958_RS02335	COG1132	(ABC) transporter
AA958_RS02395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA958_RS02410	COG0372	Belongs to the citrate synthase family
AA958_RS02425	COG0765	amino acid transport
AA958_RS02445	COG2115	Belongs to the xylose isomerase family
AA958_RS02450	COG1070	Carbohydrate kinase
AA958_RS02455	COG1349	DNA-binding transcription factor activity
AA958_RS02460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA958_RS02465	COG3395	kinase activity
AA958_RS02470	COG2610	gluconate transmembrane transporter activity
AA958_RS02475	COG1940	carbohydrate kinase activity
AA958_RS02490	COG1414	Transcriptional regulator
AA958_RS02515	COG0395	ABC-type sugar transport system, permease component
AA958_RS02520	COG1175	transmembrane transport
AA958_RS02530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AA958_RS02560	COG0444	Belongs to the ABC transporter superfamily
AA958_RS02565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA958_RS02570	COG0601	transmembrane transport
AA958_RS02590	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA958_RS02600	COG1129	ABC transporter
AA958_RS02605	COG1879	ABC-type sugar transport system periplasmic component
AA958_RS02610	COG1609	Transcriptional regulator
AA958_RS02615	COG5183	chlorophyll binding
AA958_RS02615	COG2133	pyrroloquinoline quinone binding
AA958_RS02685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA958_RS02735	COG2409	Drug exporters of the RND superfamily
AA958_RS02745	COG0531	amino acid
AA958_RS02765	COG1940	carbohydrate kinase activity
AA958_RS02780	COG0395	ABC-type sugar transport system, permease component
AA958_RS02785	COG2723	6-phospho-beta-galactosidase activity
AA958_RS02805	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
AA958_RS02825	COG2890	protein-(glutamine-N5) methyltransferase activity
AA958_RS02830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA958_RS02830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA958_RS02845	COG1063	alcohol dehydrogenase
AA958_RS02855	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AA958_RS02860	COG1691	(AIR) carboxylase
AA958_RS02865	COG1606	tRNA processing
AA958_RS02890	COG2755	lipolytic protein G-D-S-L family
AA958_RS02905	COG0277	FAD linked oxidase domain protein
AA958_RS02950	COG0668	transmembrane transport
AA958_RS02995	COG2186	Transcriptional regulator
AA958_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS03015	COG1175	transmembrane transport
AA958_RS03020	COG0395	ABC-type sugar transport system, permease component
AA958_RS03025	COG4948	Mandelate Racemase Muconate Lactonizing
AA958_RS03030	COG2814	Major facilitator Superfamily
AA958_RS03035	COG3594	Acyltransferase
AA958_RS03045	COG2390	Transcriptional regulator
AA958_RS03050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA958_RS03060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA958_RS03075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA958_RS03090	COG0194	GDP metabolic process
AA958_RS03100	COG0284	orotidine-5'-phosphate decarboxylase activity
AA958_RS03105	COG0167	dihydroorotate dehydrogenase activity
AA958_RS03110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA958_RS03115	COG0505	Belongs to the CarA family
AA958_RS03125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA958_RS03130	COG0540	Belongs to the ATCase OTCase family
AA958_RS03135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AA958_RS03145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA958_RS03150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA958_RS03155	COG0006	proline dipeptidase activity
AA958_RS03175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS03175	COG0515	serine threonine protein kinase
AA958_RS03180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA958_RS03185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA958_RS03190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA958_RS03195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AA958_RS03200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA958_RS03210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA958_RS03215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA958_RS03230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA958_RS03245	COG0124	histidyl-tRNA synthetase
AA958_RS03255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA958_RS03260	COG1196	nuclear chromosome segregation
AA958_RS03265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA958_RS03270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA958_RS03275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA958_RS03280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA958_RS03290	COG2255	four-way junction helicase activity
AA958_RS03295	COG0632	four-way junction helicase activity
AA958_RS03300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA958_RS03305	COG0217	transcriptional regulatory protein
AA958_RS03310	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AA958_RS03315	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AA958_RS03325	COG0438	transferase activity, transferring glycosyl groups
AA958_RS03330	COG1560	Kdo2-lipid A biosynthetic process
AA958_RS03335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AA958_RS03350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA958_RS03355	COG0626	cystathionine gamma-synthase activity
AA958_RS03370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA958_RS03385	COG2176	DNA-directed DNA polymerase activity
AA958_RS03385	COG5002	protein histidine kinase activity
AA958_RS03425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA958_RS03445	COG4552	Acetyltransferase involved in intracellular survival and related
AA958_RS03490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA958_RS03490	COG1648	precorrin-2 dehydrogenase activity
AA958_RS03495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA958_RS03510	COG2011	ABC-type metal ion transport system permease component
AA958_RS03515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA958_RS03535	COG0584	glycerophosphoryl diester phosphodiesterase
AA958_RS03540	COG0204	Acyl-transferase
AA958_RS03540	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS03545	COG2205	protein histidine kinase activity
AA958_RS03550	COG0745	RESPONSE REGULATOR receiver
AA958_RS03555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA958_RS03560	COG2304	oxidoreductase activity
AA958_RS03570	COG0714	Associated with various cellular activities
AA958_RS03585	COG0165	Argininosuccinate lyase
AA958_RS03590	COG0137	argininosuccinate synthase activity
AA958_RS03595	COG0471	metal ion transport
AA958_RS03600	COG0473	3-isopropylmalate dehydrogenase activity
AA958_RS03610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA958_RS03620	COG2076	Multidrug Resistance protein
AA958_RS03625	COG1438	arginine binding
AA958_RS03630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA958_RS03635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA958_RS03640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA958_RS03645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA958_RS03675	COG1649	PFAM Uncharacterised BCR, COG1649
AA958_RS03715	COG1518	maintenance of DNA repeat elements
AA958_RS03775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA958_RS03775	COG0072	phenylalanine-tRNA ligase activity
AA958_RS03780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA958_RS03785	COG5002	protein histidine kinase activity
AA958_RS03790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA958_RS03795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA958_RS03800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AA958_RS03805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA958_RS03820	COG1404	Belongs to the peptidase S8 family
AA958_RS03845	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS03860	COG1113	amino acid transport
AA958_RS03865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA958_RS03885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA958_RS03895	COG0517	IMP dehydrogenase activity
AA958_RS03895	COG4175	Glycine betaine
AA958_RS03900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA958_RS03945	COG0805	protein transport
AA958_RS03950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA958_RS03975	COG1047	Peptidyl-prolyl cis-trans
AA958_RS03980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AA958_RS03990	COG1609	Transcriptional regulator
AA958_RS03995	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AA958_RS04000	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AA958_RS04010	COG4122	O-methyltransferase activity
AA958_RS04015	COG1222	aaa ATPase
AA958_RS04030	COG1994	Peptidase M50
AA958_RS04030	COG0517	IMP dehydrogenase activity
AA958_RS04040	COG2197	response regulator
AA958_RS04045	COG0747	negative chemotaxis
AA958_RS04060	COG1410	methionine synthase
AA958_RS04060	COG0646	methionine synthase
AA958_RS04065	COG1414	Transcriptional regulator
AA958_RS04070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AA958_RS04075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA958_RS04080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA958_RS04085	COG2186	Transcriptional regulator
AA958_RS04100	COG4211	Belongs to the binding-protein-dependent transport system permease family
AA958_RS04105	COG1129	ABC transporter
AA958_RS04115	COG4948	Mandelate Racemase Muconate Lactonizing
AA958_RS04125	COG0215	cysteine-tRNA ligase activity
AA958_RS04145	COG0598	Magnesium transport protein CorA
AA958_RS04155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA958_RS04160	COG0667	Aldo Keto reductase
AA958_RS04190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA958_RS04235	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS04245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA958_RS04255	COG0477	Major facilitator Superfamily
AA958_RS04275	COG0477	Major facilitator Superfamily
AA958_RS04295	COG2814	Major facilitator Superfamily
AA958_RS04320	COG0076	glutamate decarboxylase activity
AA958_RS04325	COG1609	Transcriptional regulator
AA958_RS04335	COG1175	transmembrane transport
AA958_RS04340	COG0395	ABC-type sugar transport system, permease component
AA958_RS04365	COG3958	Transketolase
AA958_RS04405	COG0596	Alpha beta hydrolase
AA958_RS04405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA958_RS04405	COG2226	methyltransferase
AA958_RS04415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA958_RS04425	COG1309	transcriptional regulator
AA958_RS04430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA958_RS04430	COG2124	cytochrome p450
AA958_RS04445	COG3119	arylsulfatase activity
AA958_RS04450	COG0028	Belongs to the TPP enzyme family
AA958_RS04455	COG0183	Belongs to the thiolase family
AA958_RS04470	COG0747	negative chemotaxis
AA958_RS04480	COG0444	Belongs to the ABC transporter superfamily
AA958_RS04485	COG4608	Belongs to the ABC transporter superfamily
AA958_RS04490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA958_RS04500	COG2223	nitrite transmembrane transporter activity
AA958_RS04510	COG2149	membrane
AA958_RS04520	COG3265	gluconokinase activity
AA958_RS04530	COG1960	acyl-CoA dehydrogenase activity
AA958_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS04570	COG0154	amidase activity
AA958_RS04600	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AA958_RS04605	COG2188	Transcriptional regulator
AA958_RS04640	COG1725	Transcriptional regulator
AA958_RS04655	COG3409	Peptidoglycan-binding domain 1 protein
AA958_RS04655	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA958_RS04700	COG3629	intracellular signal transduction
AA958_RS04700	COG3903	Transcriptional regulator
AA958_RS04705	COG1834	amidinotransferase
AA958_RS04720	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS04725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA958_RS04730	COG0587	DNA-directed DNA polymerase activity
AA958_RS04735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AA958_RS04740	COG2197	response regulator
AA958_RS04745	COG4585	Histidine kinase
AA958_RS04775	COG2910	NAD(P)H-binding
AA958_RS04785	COG0531	amino acid
AA958_RS04790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AA958_RS04795	COG0529	Catalyzes the synthesis of activated sulfate
AA958_RS04805	COG0330	HflC and HflK could
AA958_RS04815	COG1799	cell septum assembly
AA958_RS04820	COG1960	acyl-CoA dehydrogenase activity
AA958_RS04825	COG0477	Major facilitator Superfamily
AA958_RS04830	COG0671	phosphoesterase, PA-phosphatase related
AA958_RS04840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA958_RS04845	COG0438	transferase activity, transferring glycosyl groups
AA958_RS04865	COG1137	ATPase activity
AA958_RS04875	COG3583	domain protein
AA958_RS04890	COG3293	Transposase
AA958_RS04895	COG1160	GTP binding
AA958_RS04905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA958_RS04915	COG1187	pseudouridine synthase activity
AA958_RS04920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA958_RS04940	COG0686	Belongs to the AlaDH PNT family
AA958_RS04950	COG0494	nUDIX hydrolase
AA958_RS04955	COG0504	CTP synthase activity
AA958_RS04960	COG3387	PFAM Glycoside hydrolase 15-related
AA958_RS04970	COG0497	DNA recombination
AA958_RS04975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA958_RS04990	COG1120	ATPase activity
AA958_RS04995	COG0647	UMP catabolic process
AA958_RS05025	COG2094	Belongs to the DNA glycosylase MPG family
AA958_RS05035	COG1881	PFAM PEBP family protein
AA958_RS05055	COG1119	ATPase activity
AA958_RS05075	COG2197	response regulator
AA958_RS05085	COG1131	(ABC) transporter
AA958_RS05085	COG0842	Transport permease protein
AA958_RS05085	COG1716	ATPase activity
AA958_RS05090	COG3830	Belongs to the UPF0237 family
AA958_RS05090	COG0560	Phosphoserine phosphatase
AA958_RS05105	COG2807	transmembrane transport
AA958_RS05110	COG2186	Transcriptional regulator
AA958_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS05140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA958_RS05160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA958_RS05175	COG0583	DNA-binding transcription factor activity
AA958_RS05185	COG3851	Histidine kinase
AA958_RS05190	COG2197	response regulator
AA958_RS05195	COG2176	DNA-directed DNA polymerase activity
AA958_RS05230	COG1302	Protein conserved in bacteria
AA958_RS05240	COG1024	Enoyl-CoA hydratase
AA958_RS05250	COG0488	(ABC) transporter
AA958_RS05270	COG0235	Class ii aldolase
AA958_RS05285	COG1492	cobalamin metabolic process
AA958_RS05310	COG1917	Cupin 2, conserved barrel domain protein
AA958_RS05315	COG5285	phytanoyl-CoA dioxygenase
AA958_RS05320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AA958_RS05350	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AA958_RS05355	COG1797	cobyrinic acid a,c-diamide synthase activity
AA958_RS05370	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AA958_RS05415	COG1414	Transcriptional regulator
AA958_RS05450	COG2252	PERMEase
AA958_RS05455	COG3866	Pectate lyase
AA958_RS05460	COG1653	transport
AA958_RS05475	COG0395	ABC-type sugar transport system, permease component
AA958_RS05480	COG1175	transmembrane transport
AA958_RS05495	COG1802	Transcriptional regulator
AA958_RS05545	COG2171	N-acyltransferase activity
AA958_RS05560	COG2151	metal-sulfur cluster biosynthetic enzyme
AA958_RS05565	COG0822	iron-sulfur transferase activity
AA958_RS05570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA958_RS05575	COG0396	ATPase activity
AA958_RS05585	COG0719	Fe-S assembly protein
AA958_RS05600	COG1131	(ABC) transporter
AA958_RS05610	COG1612	heme a metabolic process
AA958_RS05620	COG0109	protoheme IX farnesyltransferase activity
AA958_RS05630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA958_RS05645	COG0363	glucosamine-6-phosphate deaminase activity
AA958_RS05655	COG4821	SIS domain
AA958_RS05665	COG0166	Belongs to the GPI family
AA958_RS05680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AA958_RS05685	COG0149	triose-phosphate isomerase activity
AA958_RS05690	COG0126	phosphoglycerate kinase activity
AA958_RS05695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA958_RS05705	COG1481	regulation of sporulation
AA958_RS05710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AA958_RS05715	COG1660	Displays ATPase and GTPase activities
AA958_RS05720	COG0322	excinuclease ABC activity
AA958_RS05725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA958_RS05725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA958_RS05735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA958_RS05750	COG3509	depolymerase
AA958_RS05780	COG0556	nucleotide-excision repair
AA958_RS05785	COG0584	glycerophosphoryl diester phosphodiesterase
AA958_RS05795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA958_RS05815	COG2313	pseudouridylate synthase activity
AA958_RS05820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA958_RS05870	COG0778	Nitroreductase
AA958_RS05880	COG0237	dephospho-CoA kinase activity
AA958_RS05895	COG2409	Drug exporters of the RND superfamily
AA958_RS05900	COG2197	response regulator
AA958_RS05905	COG4585	Histidine kinase
AA958_RS05910	COG0539	negative regulation of cytoplasmic translation
AA958_RS05920	COG1643	Atp-dependent helicase
AA958_RS05985	COG0529	Catalyzes the synthesis of activated sulfate
AA958_RS05990	COG0438	transferase activity, transferring glycosyl groups
AA958_RS06005	COG2050	protein possibly involved in aromatic compounds catabolism
AA958_RS06050	COG1605	Chorismate mutase
AA958_RS06050	COG0287	Prephenate dehydrogenase
AA958_RS06055	COG0697	spore germination
AA958_RS06070	COG4585	Histidine kinase
AA958_RS06075	COG2197	response regulator
AA958_RS06090	COG3467	pyridoxamine 5'-phosphate
AA958_RS06100	COG0395	ABC-type sugar transport system, permease component
AA958_RS06105	COG1175	transmembrane transport
AA958_RS06110	COG1653	transport
AA958_RS06125	COG0067	glutamate synthase
AA958_RS06125	COG0070	glutamate synthase
AA958_RS06125	COG0069	glutamate synthase activity
AA958_RS06135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA958_RS06150	COG0159	tryptophan synthase activity
AA958_RS06155	COG0133	tryptophan synthase activity
AA958_RS06160	COG0134	indole-3-glycerol-phosphate synthase activity
AA958_RS06180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA958_RS06185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA958_RS06205	COG0745	RESPONSE REGULATOR receiver
AA958_RS06220	COG1472	Belongs to the glycosyl hydrolase 3 family
AA958_RS06225	COG0583	DNA-binding transcription factor activity
AA958_RS06235	COG1053	succinate dehydrogenase
AA958_RS06240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA958_RS06245	COG2814	Major facilitator Superfamily
AA958_RS06280	COG1131	(ABC) transporter
AA958_RS06310	COG5297	Belongs to the glycosyl hydrolase family 6
AA958_RS06315	COG4733	cellulase activity
AA958_RS06315	COG5297	Belongs to the glycosyl hydrolase family 6
AA958_RS06320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA958_RS06345	COG0183	Belongs to the thiolase family
AA958_RS06360	COG0107	imidazoleglycerol-phosphate synthase activity
AA958_RS06365	COG0251	oxidation-reduction process
AA958_RS06370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA958_RS06375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA958_RS06385	COG0131	Imidazoleglycerol-phosphate dehydratase
AA958_RS06390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA958_RS06395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA958_RS06410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA958_RS06445	COG0587	DNA-directed DNA polymerase activity
AA958_RS06480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA958_RS06490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA958_RS06505	COG1799	cell septum assembly
AA958_RS06510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AA958_RS06520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA958_RS06525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AA958_RS06530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA958_RS06540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA958_RS06545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA958_RS06555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA958_RS06560	COG0768	penicillin binding
AA958_RS06570	COG0275	rRNA processing
AA958_RS06580	COG0714	Associated with various cellular activities
AA958_RS06625	COG0352	thiamine-phosphate diphosphorylase activity
AA958_RS06640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA958_RS06640	COG2022	thiamine diphosphate biosynthetic process
AA958_RS06650	COG2022	thiamine diphosphate biosynthetic process
AA958_RS06655	COG2815	serine threonine protein kinase
AA958_RS06655	COG0515	serine threonine protein kinase
AA958_RS06660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AA958_RS06665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA958_RS06670	COG2193	ferroxidase activity
AA958_RS06675	COG0243	molybdopterin cofactor binding
AA958_RS06680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA958_RS06690	COG0205	6-phosphofructokinase activity
AA958_RS06695	COG2197	response regulator
AA958_RS06730	COG1940	carbohydrate kinase activity
AA958_RS06740	COG0003	Pfam Anion-transporting ATPase
AA958_RS06760	COG0438	transferase activity, transferring glycosyl groups
AA958_RS06805	COG2205	protein histidine kinase activity
AA958_RS06815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA958_RS06820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA958_RS06825	COG0723	plastoquinol--plastocyanin reductase activity
AA958_RS06830	COG2010	Cytochrome c
AA958_RS06835	COG1845	cytochrome c oxidase, subunit III
AA958_RS06845	COG1376	ErfK ybiS ycfS ynhG family protein
AA958_RS06855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA958_RS06860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA958_RS06865	COG1104	cysteine desulfurase activity
AA958_RS06870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA958_RS06890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AA958_RS06900	COG2197	response regulator
AA958_RS06905	COG4585	Histidine kinase
AA958_RS06935	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA958_RS06940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA958_RS06945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA958_RS06950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA958_RS06955	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA958_RS06960	COG2319	Wd-40 repeat
AA958_RS06960	COG4249	Peptidase C14 caspase catalytic subunit p20
AA958_RS06985	COG0733	neurotransmitter:sodium symporter activity
AA958_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS07025	COG0321	lipoyl(octanoyl) transferase activity
AA958_RS07030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA958_RS07070	COG0583	DNA-binding transcription factor activity
AA958_RS07075	COG2755	lipolytic protein G-D-S-L family
AA958_RS07080	COG3835	regulator
AA958_RS07085	COG4106	trans-aconitate 2-methyltransferase activity
AA958_RS07135	COG4585	Histidine kinase
AA958_RS07140	COG2197	response regulator
AA958_RS07155	COG0174	glutamine synthetase
AA958_RS07170	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AA958_RS07180	COG3973	AAA domain
AA958_RS07185	COG1309	transcriptional regulator
AA958_RS07225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA958_RS07230	COG0477	Major facilitator Superfamily
AA958_RS07250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA958_RS07250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA958_RS07285	COG0667	Aldo Keto reductase
AA958_RS07290	COG1609	Transcriptional regulator
AA958_RS07300	COG1175	transmembrane transport
AA958_RS07305	COG0395	ABC-type sugar transport system, permease component
AA958_RS07315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA958_RS07320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA958_RS07325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AA958_RS07340	COG0463	Glycosyl transferase, family 2
AA958_RS07345	COG2249	NAD(P)H dehydrogenase (quinone) activity
AA958_RS07350	COG3547	Transposase (IS116 IS110 IS902 family)
AA958_RS07365	COG0438	transferase activity, transferring glycosyl groups
AA958_RS07380	COG1834	amidinotransferase
AA958_RS07405	COG0297	glycogen (starch) synthase activity
AA958_RS07410	COG0489	protein tyrosine kinase activity
AA958_RS07420	COG3540	Alkaline phosphatase
AA958_RS07430	COG2346	COG2346, Truncated hemoglobins
AA958_RS07440	COG1793	dna ligase
AA958_RS07440	COG3285	dna ligase
AA958_RS07445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AA958_RS07470	COG1609	Transcriptional regulator
AA958_RS07480	COG0673	inositol 2-dehydrogenase activity
AA958_RS07525	COG0557	exoribonuclease II activity
AA958_RS07535	COG0076	glutamate decarboxylase activity
AA958_RS07575	COG1201	RNA secondary structure unwinding
AA958_RS07600	COG0589	response to stress
AA958_RS07685	COG3022	response to hydroperoxide
AA958_RS07690	COG0800	Aldolase
AA958_RS07705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AA958_RS07715	COG2030	dehydratase
AA958_RS07730	COG3510	cephalosporin hydroxylase
AA958_RS07755	COG1309	transcriptional regulator
AA958_RS07760	COG0438	transferase activity, transferring glycosyl groups
AA958_RS07775	COG1657	PFAM Prenyltransferase squalene oxidase
AA958_RS07790	COG3845	ABC transporter
AA958_RS07800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA958_RS07860	COG1295	ribonuclease BN
AA958_RS07885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA958_RS07890	COG3226	Transcriptional regulator
AA958_RS07935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AA958_RS07950	COG0640	Transcriptional regulator
AA958_RS07995	COG1234	tRNA 3'-trailer cleavage
AA958_RS08010	COG3409	Peptidoglycan-binding domain 1 protein
AA958_RS08010	COG3757	hydrolase, family 25
AA958_RS08035	COG1090	epimerase
AA958_RS08050	COG2409	Drug exporters of the RND superfamily
AA958_RS08055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA958_RS08065	COG1309	transcriptional regulator
AA958_RS08070	COG3629	intracellular signal transduction
AA958_RS08105	COG1358	cellular component organization or biogenesis
AA958_RS08140	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AA958_RS08145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA958_RS08150	COG0667	Aldo Keto reductase
AA958_RS08155	COG0789	Transcriptional regulator
AA958_RS08180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA958_RS08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA958_RS08190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA958_RS08210	COG4948	Mandelate Racemase Muconate Lactonizing
AA958_RS08230	COG1129	ABC transporter
AA958_RS08235	COG4214	carbohydrate transport
AA958_RS08250	COG0667	Aldo Keto reductase
AA958_RS08255	COG3386	PFAM SMP-30 Gluconolaconase
AA958_RS08260	COG1414	Transcriptional regulator
AA958_RS08290	COG4981	capsule polysaccharide biosynthetic process
AA958_RS08310	COG2835	tetraacyldisaccharide 4'-kinase activity
AA958_RS08315	COG1196	nuclear chromosome segregation
AA958_RS08315	COG0741	lytic transglycosylase activity
AA958_RS08315	COG0739	heme binding
AA958_RS08330	COG1653	transport
AA958_RS08365	COG0366	Alpha amylase catalytic
AA958_RS08380	COG0604	alcohol dehydrogenase
AA958_RS08450	COG1396	sequence-specific DNA binding
AA958_RS08490	COG2837	iron assimilation
AA958_RS08520	COG1309	transcriptional regulator
AA958_RS08545	COG1846	Transcriptional regulator
AA958_RS08550	COG2814	Major facilitator Superfamily
AA958_RS08555	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AA958_RS08575	COG4106	trans-aconitate 2-methyltransferase activity
AA958_RS08600	COG0659	secondary active sulfate transmembrane transporter activity
AA958_RS08605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA958_RS08610	COG1595	DNA-templated transcription, initiation
AA958_RS08625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA958_RS08630	COG1595	DNA-templated transcription, initiation
AA958_RS08655	COG2706	6-phosphogluconolactonase activity
AA958_RS08660	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS08675	COG3209	COG3209 Rhs family protein
AA958_RS08675	COG3209	COG3209 Rhs family protein
AA958_RS08705	COG3751	2OG-Fe(II) oxygenase superfamily
AA958_RS08740	COG2192	nodulation
AA958_RS08780	COG1070	Carbohydrate kinase
AA958_RS08800	COG0366	Alpha amylase catalytic
AA958_RS08805	COG0395	ABC-type sugar transport system, permease component
AA958_RS08810	COG1175	transmembrane transport
AA958_RS08830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA958_RS08840	COG0358	DNA primase activity
AA958_RS08895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA958_RS08910	COG2226	methyltransferase
AA958_RS08925	COG2197	response regulator
AA958_RS08930	COG4585	Histidine kinase
AA958_RS08945	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AA958_RS08955	COG2146	nitrite reductase [NAD(P)H] activity
AA958_RS08955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA958_RS08960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA958_RS08995	COG2949	membrane
AA958_RS09010	COG0243	molybdopterin cofactor binding
AA958_RS09025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS09025	COG0515	serine threonine protein kinase
AA958_RS09035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA958_RS09035	COG0574	Belongs to the PEP-utilizing enzyme family
AA958_RS09055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AA958_RS09060	COG0494	nUDIX hydrolase
AA958_RS09065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA958_RS09070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA958_RS09070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA958_RS09115	COG0515	serine threonine protein kinase
AA958_RS09115	COG2815	serine threonine protein kinase
AA958_RS09120	COG0477	Major facilitator Superfamily
AA958_RS09160	COG3547	Transposase (IS116 IS110 IS902 family)
AA958_RS09165	COG0667	Aldo Keto reductase
AA958_RS09180	COG0423	glycine-tRNA ligase activity
AA958_RS09190	COG1121	(ABC) transporter
AA958_RS09195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA958_RS09205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA958_RS09210	COG1381	Involved in DNA repair and RecF pathway recombination
AA958_RS09220	COG2186	Transcriptional regulator
AA958_RS09225	COG2197	response regulator
AA958_RS09235	COG2409	Drug exporters of the RND superfamily
AA958_RS09250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA958_RS09260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA958_RS09265	COG0667	Aldo Keto reductase
AA958_RS09270	COG0583	DNA-binding transcription factor activity
AA958_RS09290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA958_RS09325	COG1234	tRNA 3'-trailer cleavage
AA958_RS09330	COG0537	adenosine 5'-monophosphoramidase activity
AA958_RS09335	COG0793	Belongs to the peptidase S41A family
AA958_RS09335	COG4946	Tricorn protease homolog
AA958_RS09350	COG0484	heat shock protein binding
AA958_RS09355	COG1420	regulation of RNA biosynthetic process
AA958_RS09385	COG1022	Amp-dependent synthetase and ligase
AA958_RS09390	COG0481	GTPase activity
AA958_RS09395	COG0268	Binds directly to 16S ribosomal RNA
AA958_RS09410	COG2353	YceI-like domain
AA958_RS09420	COG1596	polysaccharide export
AA958_RS09420	COG1555	photosystem II stabilization
AA958_RS09425	COG1307	EDD domain protein, DegV family
AA958_RS09435	COG0495	leucyl-tRNA aminoacylation
AA958_RS09450	COG0477	Major facilitator Superfamily
AA958_RS09465	COG0588	phosphoglycerate mutase activity
AA958_RS09480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA958_RS09490	COG0501	Belongs to the peptidase M48B family
AA958_RS09505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA958_RS09515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA958_RS09525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA958_RS09530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA958_RS09535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA958_RS09545	COG1530	ribonuclease E activity
AA958_RS09590	COG0772	Belongs to the SEDS family
AA958_RS09610	COG1077	Cell shape determining protein MreB Mrl
AA958_RS09615	COG0105	UTP biosynthetic process
AA958_RS09625	COG0285	dihydrofolate synthase activity
AA958_RS09630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA958_RS09635	COG0525	valine-tRNA ligase activity
AA958_RS09645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA958_RS09650	COG0740	serine-type endopeptidase activity
AA958_RS09655	COG0740	serine-type endopeptidase activity
AA958_RS09660	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA958_RS09680	COG3594	Acyltransferase
AA958_RS09690	COG1136	(ABC) transporter
AA958_RS09700	COG2208	phosphoserine phosphatase activity
AA958_RS09715	COG1268	BioY protein
AA958_RS09720	COG1113	amino acid transport
AA958_RS09775	COG1302	Protein conserved in bacteria
AA958_RS09820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AA958_RS09830	COG1486	melibiose metabolic process
AA958_RS09835	COG0395	ABC-type sugar transport system, permease component
AA958_RS09845	COG1653	transport
AA958_RS09870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA958_RS09940	COG4257	antibiotic catabolic process
AA958_RS09960	COG1136	(ABC) transporter
AA958_RS09985	COG0629	single-stranded DNA binding
AA958_RS10045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA958_RS10055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA958_RS10090	COG3903	Transcriptional regulator
AA958_RS10090	COG3629	intracellular signal transduction
AA958_RS10095	COG0596	Alpha beta hydrolase
AA958_RS10105	COG2197	response regulator
AA958_RS10110	COG4585	Histidine kinase
AA958_RS10115	COG2409	Drug exporters of the RND superfamily
AA958_RS10120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AA958_RS10130	COG4935	Belongs to the peptidase S8 family
AA958_RS10130	COG2234	aminopeptidase activity
AA958_RS10145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AA958_RS10155	COG0726	polysaccharide deacetylase
AA958_RS10170	COG0531	amino acid
AA958_RS10175	COG0586	Pfam SNARE associated Golgi protein
AA958_RS10200	COG2409	Drug exporters of the RND superfamily
AA958_RS10220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AA958_RS10240	COG0673	inositol 2-dehydrogenase activity
AA958_RS10245	COG1609	Transcriptional regulator
AA958_RS10275	COG0583	DNA-binding transcription factor activity
AA958_RS10315	COG1946	Acyl-CoA thioesterase
AA958_RS10325	COG1309	transcriptional regulator
AA958_RS10330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA958_RS10345	COG1960	acyl-CoA dehydrogenase activity
AA958_RS10365	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AA958_RS10370	COG4264	IucA IucC family
AA958_RS10375	COG4941	Belongs to the sigma-70 factor family
AA958_RS10380	COG3795	YCII-related domain
AA958_RS10400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AA958_RS10405	COG4977	sequence-specific DNA binding
AA958_RS10420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA958_RS10425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA958_RS10445	COG4733	cellulase activity
AA958_RS10445	COG5297	Belongs to the glycosyl hydrolase family 6
AA958_RS10560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA958_RS10565	COG0154	amidase activity
AA958_RS10580	COG0765	amino acid transport
AA958_RS10585	COG0765	amino acid transport
AA958_RS10590	COG1126	abc transporter atp-binding protein
AA958_RS10615	COG0673	inositol 2-dehydrogenase activity
AA958_RS10645	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA958_RS10655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA958_RS10670	COG4555	ABC transporter
AA958_RS10685	COG2733	membrane
AA958_RS10690	COG0706	membrane insertase activity
AA958_RS10695	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA958_RS10700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA958_RS10710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA958_RS10715	COG1234	tRNA 3'-trailer cleavage
AA958_RS10740	COG1113	amino acid transport
AA958_RS10750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA958_RS10760	COG1335	isochorismatase
AA958_RS10795	COG4977	sequence-specific DNA binding
AA958_RS10820	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AA958_RS10830	COG0277	FAD linked oxidase domain protein
AA958_RS10850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA958_RS10875	COG1733	regulation of RNA biosynthetic process
AA958_RS10895	COG1733	regulation of RNA biosynthetic process
AA958_RS10920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA958_RS10935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AA958_RS10945	COG1678	Uncharacterized ACR, COG1678
AA958_RS10950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA958_RS10955	COG0776	regulation of translation
AA958_RS10965	COG3973	AAA domain
AA958_RS11000	COG0640	Transcriptional regulator
AA958_RS11020	COG0583	DNA-binding transcription factor activity
AA958_RS11040	COG2706	6-phosphogluconolactonase activity
AA958_RS11045	COG1653	transport
AA958_RS11050	COG1175	transmembrane transport
AA958_RS11055	COG0395	ABC-type sugar transport system, permease component
AA958_RS11060	COG1501	Belongs to the glycosyl hydrolase 31 family
AA958_RS11070	COG1472	Belongs to the glycosyl hydrolase 3 family
AA958_RS11080	COG0395	ABC-type sugar transport system, permease component
AA958_RS11090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AA958_RS11095	COG0604	alcohol dehydrogenase
AA958_RS11095	COG3321	synthase
AA958_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS11140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA958_RS11145	COG0793	Belongs to the peptidase S41A family
AA958_RS11150	COG2177	Part of the ABC transporter FtsEX involved in
AA958_RS11155	COG2884	Cell division ATP-binding protein ftsE
AA958_RS11165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AA958_RS11170	COG0515	serine threonine protein kinase
AA958_RS11175	COG0515	serine threonine protein kinase
AA958_RS11180	COG1716	ATPase activity
AA958_RS11185	COG1653	transport
AA958_RS11190	COG1175	transmembrane transport
AA958_RS11195	COG0395	ABC-type sugar transport system, permease component
AA958_RS11200	COG1216	Glycosyl transferase, family 2
AA958_RS11205	COG0438	transferase activity, transferring glycosyl groups
AA958_RS11220	COG0438	transferase activity, transferring glycosyl groups
AA958_RS11225	COG0438	transferase activity, transferring glycosyl groups
AA958_RS11235	COG0438	transferase activity, transferring glycosyl groups
AA958_RS11240	COG2902	Dehydrogenase
AA958_RS11245	COG0546	phosphoglycolate phosphatase activity
AA958_RS11260	COG0653	protein targeting
AA958_RS11275	COG3214	Protein conserved in bacteria
AA958_RS11280	COG2197	response regulator
AA958_RS11285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA958_RS11295	COG0823	Involved in the tonB-independent uptake of proteins
AA958_RS11300	COG5002	protein histidine kinase activity
AA958_RS11305	COG0745	RESPONSE REGULATOR receiver
AA958_RS11310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AA958_RS11335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA958_RS11345	COG1482	cell wall glycoprotein biosynthetic process
AA958_RS11360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA958_RS11400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AA958_RS11405	COG0778	Nitroreductase
AA958_RS11405	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AA958_RS11410	COG1316	TRANSCRIPTIONal
AA958_RS11420	COG1316	TRANSCRIPTIONal
AA958_RS11430	COG1316	TRANSCRIPTIONal
AA958_RS11435	COG1316	TRANSCRIPTIONal
AA958_RS11440	COG1316	TRANSCRIPTIONal
AA958_RS11465	COG1316	TRANSCRIPTIONal
AA958_RS11470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AA958_RS11485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AA958_RS11500	COG2205	protein histidine kinase activity
AA958_RS11505	COG0745	RESPONSE REGULATOR receiver
AA958_RS11525	COG1191	sigma factor activity
AA958_RS11535	COG1228	amidohydrolase
AA958_RS11550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AA958_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS11575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AA958_RS11580	COG0531	amino acid
AA958_RS11595	COG0183	Belongs to the thiolase family
AA958_RS11615	COG0577	efflux transmembrane transporter activity
AA958_RS11620	COG1136	(ABC) transporter
AA958_RS11650	COG2755	lipolytic protein G-D-S-L family
AA958_RS11680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA958_RS11685	COG1252	NADH dehydrogenase
AA958_RS11690	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AA958_RS11695	COG2188	Transcriptional regulator
AA958_RS11730	COG0148	phosphopyruvate hydratase activity
AA958_RS11740	COG1652	LysM domain
AA958_RS11745	COG2124	cytochrome p450
AA958_RS11770	COG1216	Glycosyl transferase, family 2
AA958_RS11795	COG2814	Major facilitator Superfamily
AA958_RS11800	COG0640	Transcriptional regulator
AA958_RS11850	COG2318	DinB family
AA958_RS11885	COG1136	(ABC) transporter
AA958_RS11890	COG0577	efflux transmembrane transporter activity
AA958_RS11925	COG1966	Carbon starvation protein
AA958_RS11985	COG4585	Histidine kinase
AA958_RS12000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA958_RS12005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA958_RS12010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA958_RS12015	COG0193	aminoacyl-tRNA hydrolase activity
AA958_RS12025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AA958_RS12035	COG1309	transcriptional regulator
AA958_RS12045	COG4106	trans-aconitate 2-methyltransferase activity
AA958_RS12055	COG2197	response regulator
AA958_RS12060	COG2197	response regulator
AA958_RS12085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AA958_RS12095	COG0488	(ABC) transporter
AA958_RS12100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AA958_RS12105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA958_RS12110	COG0084	hydrolase, TatD family'
AA958_RS12135	COG0442	prolyl-tRNA aminoacylation
AA958_RS12155	COG1122	ATPase activity
AA958_RS12165	COG0310	cobalt ion transport
AA958_RS12170	COG0793	Belongs to the peptidase S41A family
AA958_RS12170	COG4946	Tricorn protease homolog
AA958_RS12185	COG2267	carboxylic ester hydrolase activity
AA958_RS12190	COG2072	flavoprotein involved in K transport
AA958_RS12210	COG4941	Belongs to the sigma-70 factor family
AA958_RS12230	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA958_RS12235	COG2050	protein possibly involved in aromatic compounds catabolism
AA958_RS12270	COG1609	Transcriptional regulator
AA958_RS12285	COG1509	lysine 2,3-aminomutase activity
AA958_RS12290	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA958_RS12305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA958_RS12330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA958_RS12335	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA958_RS12340	COG0315	cyclic pyranopterin monophosphate synthase activity
AA958_RS12350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AA958_RS12355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA958_RS12365	COG3263	regulation of cellular component size
AA958_RS12380	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AA958_RS12395	COG3191	aminopeptidase activity
AA958_RS12415	COG3384	dioxygenase
AA958_RS12430	COG1764	response to oxidative stress
AA958_RS12490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA958_RS12520	COG3835	regulator
AA958_RS12535	COG1309	transcriptional regulator
AA958_RS12550	COG0183	Belongs to the thiolase family
AA958_RS12605	COG2837	iron assimilation
AA958_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS12690	COG1132	(ABC) transporter
AA958_RS12695	COG1132	(ABC) transporter
AA958_RS12695	COG2375	cellular response to nickel ion
AA958_RS12705	COG0477	Major facilitator Superfamily
AA958_RS12725	COG3118	belongs to the thioredoxin family
AA958_RS12800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA958_RS12835	COG0500	methyltransferase
AA958_RS12840	COG2072	flavoprotein involved in K transport
AA958_RS12855	COG0515	serine threonine protein kinase
AA958_RS12855	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS12865	COG1733	regulation of RNA biosynthetic process
AA958_RS12900	COG2318	DinB family
AA958_RS12910	COG0438	transferase activity, transferring glycosyl groups
AA958_RS13090	COG1674	ftsk spoiiie
AA958_RS13100	COG2945	thiolester hydrolase activity
AA958_RS13100	COG0596	Alpha beta hydrolase
AA958_RS13115	COG0259	pyridoxamine-phosphate oxidase activity
AA958_RS13145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA958_RS13160	COG0247	lactate metabolic process
AA958_RS13160	COG0277	FAD linked oxidase domain protein
AA958_RS13170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AA958_RS13195	COG0667	Aldo Keto reductase
AA958_RS13210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA958_RS13220	COG2252	PERMEase
AA958_RS13225	COG1846	Transcriptional regulator
AA958_RS13255	COG1278	Cold shock
AA958_RS13260	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AA958_RS13265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA958_RS13275	COG2814	Major facilitator Superfamily
AA958_RS13305	COG1061	Type III restriction enzyme res subunit
AA958_RS13315	COG0673	inositol 2-dehydrogenase activity
AA958_RS13320	COG1082	Xylose isomerase domain protein TIM barrel
AA958_RS13330	COG3962	Belongs to the TPP enzyme family
AA958_RS13335	COG3718	enzyme involved in inositol metabolism
AA958_RS13345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA958_RS13350	COG0395	ABC-type sugar transport system, permease component
AA958_RS13355	COG1175	transmembrane transport
AA958_RS13365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA958_RS13380	COG1486	melibiose metabolic process
AA958_RS13395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA958_RS13410	COG2814	Major facilitator Superfamily
AA958_RS13420	COG3842	ATPase activity
AA958_RS13430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA958_RS13440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA958_RS13445	COG0215	cysteine-tRNA ligase activity
AA958_RS13450	COG0259	pyridoxamine-phosphate oxidase activity
AA958_RS13455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AA958_RS13460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA958_RS13465	COG1329	Transcriptional regulator
AA958_RS13480	COG5002	protein histidine kinase activity
AA958_RS13490	COG0588	phosphoglycerate mutase activity
AA958_RS13520	COG0438	transferase activity, transferring glycosyl groups
AA958_RS13530	COG1309	transcriptional regulator
AA958_RS13540	COG0494	nUDIX hydrolase
AA958_RS13540	COG0406	alpha-ribazole phosphatase activity
AA958_RS13550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA958_RS13555	COG0456	acetyltransferase
AA958_RS13560	COG0737	Belongs to the 5'-nucleotidase family
AA958_RS13575	COG0745	RESPONSE REGULATOR receiver
AA958_RS13580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA958_RS13600	COG1609	Transcriptional regulator
AA958_RS13605	COG0745	RESPONSE REGULATOR receiver
AA958_RS13640	COG2897	thiosulfate sulfurtransferase activity
AA958_RS13680	COG3485	protocatechuate 3,4-dioxygenase
AA958_RS13685	COG0735	belongs to the Fur family
AA958_RS13690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA958_RS13695	COG1490	D-aminoacyl-tRNA deacylase activity
AA958_RS13710	COG4552	Acetyltransferase involved in intracellular survival and related
AA958_RS13780	COG2027	D-alanyl-D-alanine carboxypeptidase
AA958_RS13785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA958_RS13815	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS13840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AA958_RS13845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA958_RS13855	COG5002	protein histidine kinase activity
AA958_RS13860	COG0745	RESPONSE REGULATOR receiver
AA958_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS13935	COG1309	transcriptional regulator
AA958_RS13940	COG1960	acyl-CoA dehydrogenase activity
AA958_RS13965	COG1764	response to oxidative stress
AA958_RS13970	COG0739	heme binding
AA958_RS13990	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA958_RS13995	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA958_RS14000	COG1129	ABC transporter
AA958_RS14020	COG1595	DNA-templated transcription, initiation
AA958_RS14025	COG0737	Belongs to the 5'-nucleotidase family
AA958_RS14025	COG1525	nuclease
AA958_RS14025	COG4085	toxin activity
AA958_RS14065	COG0477	Major facilitator Superfamily
AA958_RS14075	COG3619	membrane
AA958_RS14085	COG0583	DNA-binding transcription factor activity
AA958_RS14090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA958_RS14090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA958_RS14100	COG3291	Pkd domain containing protein
AA958_RS14140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AA958_RS14165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AA958_RS14185	COG0789	Transcriptional regulator
AA958_RS14205	COG0596	Alpha beta hydrolase
AA958_RS14210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA958_RS14215	COG0459	protein refolding
AA958_RS14225	COG4948	Mandelate Racemase Muconate Lactonizing
AA958_RS14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA958_RS14245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA958_RS14250	COG4521	taurine ABC transporter
AA958_RS14255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA958_RS14260	COG0473	3-isopropylmalate dehydrogenase activity
AA958_RS14260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA958_RS14265	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS14280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA958_RS14285	COG1754	DNA topoisomerase type I activity
AA958_RS14285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA958_RS14310	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AA958_RS14315	COG2172	sigma factor antagonist activity
AA958_RS14320	COG1366	Belongs to the anti-sigma-factor antagonist family
AA958_RS14325	COG1205	dead DEAH box helicase
AA958_RS14325	COG1111	helicase
AA958_RS14390	COG0659	secondary active sulfate transmembrane transporter activity
AA958_RS14395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA958_RS14410	COG2267	carboxylic ester hydrolase activity
AA958_RS14435	COG2268	Band 7 protein
AA958_RS14460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA958_RS14475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA958_RS14495	COG0003	Pfam Anion-transporting ATPase
AA958_RS14505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA958_RS14515	COG1408	metallophosphoesterase
AA958_RS14540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA958_RS14580	COG3903	Transcriptional regulator
AA958_RS14580	COG3629	intracellular signal transduction
AA958_RS14595	COG1595	DNA-templated transcription, initiation
AA958_RS14600	COG2318	DinB family
AA958_RS14615	COG0477	Major facilitator Superfamily
AA958_RS14630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA958_RS14685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA958_RS14690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA958_RS14725	COG1959	2 iron, 2 sulfur cluster binding
AA958_RS14725	COG1295	ribonuclease BN
AA958_RS14755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA958_RS14760	COG3328	transposase activity
AA958_RS14800	COG2815	serine threonine protein kinase
AA958_RS14800	COG0515	serine threonine protein kinase
AA958_RS14815	COG2409	Drug exporters of the RND superfamily
AA958_RS14825	COG0640	Transcriptional regulator
AA958_RS14830	COG0662	Cupin 2, conserved barrel domain protein
AA958_RS14835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA958_RS14840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA958_RS14845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA958_RS14850	COG2867	negative regulation of translational initiation
AA958_RS14850	COG2226	methyltransferase
AA958_RS14870	COG0210	DNA helicase
AA958_RS14875	COG1278	Cold shock
AA958_RS14885	COG0745	RESPONSE REGULATOR receiver
AA958_RS14905	COG1073	alpha beta
AA958_RS14930	COG0640	Transcriptional regulator
AA958_RS15015	COG1295	ribonuclease BN
AA958_RS15025	COG1597	lipid kinase activity
AA958_RS15030	COG1191	sigma factor activity
AA958_RS15055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA958_RS15060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA958_RS15075	COG0640	Transcriptional regulator
AA958_RS15080	COG2814	Major facilitator Superfamily
AA958_RS15105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA958_RS15110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA958_RS15120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA958_RS15125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AA958_RS15130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA958_RS15160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA958_RS15170	COG2814	Major facilitator Superfamily
AA958_RS15215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA958_RS15235	COG3189	MarR family transcriptional regulator
AA958_RS15265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA958_RS15305	COG1191	sigma factor activity
AA958_RS15310	COG1191	sigma factor activity
AA958_RS15385	COG2188	Transcriptional regulator
AA958_RS15400	COG3415	Transposase
AA958_RS15400	COG2801	Transposase and inactivated derivatives
AA958_RS15410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA958_RS15410	COG0116	Belongs to the methyltransferase superfamily
AA958_RS15415	COG2318	DinB family
AA958_RS15420	COG1396	sequence-specific DNA binding
AA958_RS15425	COG0740	serine-type endopeptidase activity
AA958_RS15430	COG0740	serine-type endopeptidase activity
AA958_RS15435	COG2204	response regulator
AA958_RS15440	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS15445	COG1595	DNA-templated transcription, initiation
AA958_RS15485	COG0456	acetyltransferase
AA958_RS15500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA958_RS15515	COG0653	protein targeting
AA958_RS15530	COG0006	proline dipeptidase activity
AA958_RS15535	COG2205	protein histidine kinase activity
AA958_RS15540	COG0745	RESPONSE REGULATOR receiver
AA958_RS15575	COG0076	glutamate decarboxylase activity
AA958_RS15600	COG1064	alcohol dehydrogenase
AA958_RS15605	COG1309	transcriptional regulator
AA958_RS15650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA958_RS15710	COG2372	response to copper ion
AA958_RS15715	COG2837	iron assimilation
AA958_RS15725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA958_RS15730	COG0561	phosphatase activity
AA958_RS15740	COG0583	DNA-binding transcription factor activity
AA958_RS15745	COG1280	lysine exporter protein (LysE YggA)
AA958_RS15755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA958_RS15770	COG1131	(ABC) transporter
AA958_RS15775	COG4585	Histidine kinase
AA958_RS15780	COG2197	response regulator
AA958_RS15785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA958_RS15790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA958_RS15795	COG0583	DNA-binding transcription factor activity
AA958_RS15825	COG2814	Major facilitator Superfamily
AA958_RS15840	COG1733	regulation of RNA biosynthetic process
AA958_RS15870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA958_RS15885	COG0662	Cupin 2, conserved barrel domain protein
AA958_RS15890	COG1950	PFAM Membrane protein of
AA958_RS15895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA958_RS15900	COG3001	Fructosamine kinase
AA958_RS15905	COG0626	cystathionine gamma-synthase activity
AA958_RS15930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA958_RS15935	COG1609	Transcriptional regulator
AA958_RS15940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA958_RS15945	COG1271	oxidase subunit
AA958_RS15950	COG1294	oxidase, subunit
AA958_RS15955	COG4988	ABC transporter
AA958_RS15965	COG0561	phosphatase activity
AA958_RS15975	COG0583	DNA-binding transcription factor activity
AA958_RS15985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA958_RS16030	COG1131	(ABC) transporter
AA958_RS16040	COG1131	(ABC) transporter
AA958_RS16055	COG0305	Participates in initiation and elongation during chromosome replication
AA958_RS16055	COG1372	Participates in initiation and elongation during chromosome replication
AA958_RS16065	COG0359	binds to the 23S rRNA
AA958_RS16070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AA958_RS16080	COG0360	Binds together with S18 to 16S ribosomal RNA
AA958_RS16105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA958_RS16110	COG1695	Transcriptional regulator
AA958_RS16115	COG1260	myo-inositol-1-phosphate synthase
AA958_RS16125	COG0617	tRNA 3'-terminal CCA addition
AA958_RS16135	COG0728	peptidoglycan biosynthetic process
AA958_RS16140	COG0515	serine threonine protein kinase
AA958_RS16140	COG2815	serine threonine protein kinase
AA958_RS16145	COG1595	DNA-templated transcription, initiation
AA958_RS16155	COG0492	ferredoxin-NADP+ reductase activity
AA958_RS16160	COG3118	belongs to the thioredoxin family
AA958_RS16175	COG1192	Involved in chromosome partitioning
AA958_RS16180	COG0357	Ribosomal RNA small subunit methyltransferase G
AA958_RS16190	COG0706	membrane insertase activity
AA958_RS16195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA958_RS16200	COG0594	ribonuclease P activity
AA958_RS16205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AA958_RS16210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA958_RS16215	COG0592	DNA-directed DNA polymerase activity
AA958_RS16220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AA958_RS16225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA958_RS16230	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AA958_RS16240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA958_RS16280	COG0515	serine threonine protein kinase
AA958_RS16290	COG3764	Sortase (surface protein transpeptidase)
AA958_RS16320	COG0705	Rhomboid family
AA958_RS16340	COG0515	serine threonine protein kinase
AA958_RS16360	COG1716	ATPase activity
AA958_RS16365	COG1716	ATPase activity
AA958_RS16390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA958_RS16395	COG2151	metal-sulfur cluster biosynthetic enzyme
AA958_RS16400	COG3396	Phenylacetate-CoA oxygenase
AA958_RS16405	COG3460	Phenylacetate-CoA oxygenase
AA958_RS16410	COG3396	Phenylacetate-CoA oxygenase
AA958_RS16445	COG1309	transcriptional regulator
AA958_RS16450	COG1522	sequence-specific DNA binding
AA958_RS16470	COG0746	molybdenum cofactor guanylyltransferase activity
AA958_RS16475	COG0303	'Molybdopterin
AA958_RS16480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA958_RS16485	COG0604	alcohol dehydrogenase
AA958_RS16495	COG0456	acetyltransferase
AA958_RS16495	COG0454	-acetyltransferase
AA958_RS16505	COG0515	serine threonine protein kinase
AA958_RS16510	COG0515	serine threonine protein kinase
AA958_RS16525	COG0022	dehydrogenase e1 component
AA958_RS16530	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA958_RS16540	COG2271	Major facilitator Superfamily
AA958_RS16545	COG1077	Cell shape determining protein MreB Mrl
AA958_RS16580	COG1362	aminopeptidase activity
AA958_RS16590	COG1960	acyl-CoA dehydrogenase activity
AA958_RS16615	COG0596	Alpha beta hydrolase
AA958_RS16630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA958_RS16640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA958_RS16655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA958_RS16660	COG0745	RESPONSE REGULATOR receiver
AA958_RS16665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA958_RS16705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA958_RS16730	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA958_RS16750	COG0542	response to heat
AA958_RS16815	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA958_RS16815	COG1672	PFAM Archaeal ATPase
AA958_RS16825	COG1733	regulation of RNA biosynthetic process
AA958_RS16840	COG1595	DNA-templated transcription, initiation
AA958_RS16855	COG0477	Major facilitator Superfamily
AA958_RS16890	COG0789	Transcriptional regulator
AA958_RS16945	COG1846	Transcriptional regulator
AA958_RS16955	COG1595	DNA-templated transcription, initiation
AA958_RS17010	COG1960	acyl-CoA dehydrogenase activity
AA958_RS17015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA958_RS17030	COG4172	Belongs to the ABC transporter superfamily
AA958_RS17040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA958_RS17045	COG0601	transmembrane transport
AA958_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS17175	COG2814	Major facilitator Superfamily
AA958_RS17185	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA958_RS17235	COG0328	RNA-DNA hybrid ribonuclease activity
AA958_RS17260	COG1309	transcriptional regulator
AA958_RS17295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA958_RS17325	COG0601	transmembrane transport
AA958_RS17340	COG4608	Belongs to the ABC transporter superfamily
AA958_RS17375	COG0515	serine threonine protein kinase
AA958_RS17395	COG2208	phosphoserine phosphatase activity
AA958_RS17395	COG2172	sigma factor antagonist activity
AA958_RS17395	COG1366	Belongs to the anti-sigma-factor antagonist family
AA958_RS17415	COG3383	formate dehydrogenase (NAD+) activity
AA958_RS17440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA958_RS17475	COG0129	dihydroxy-acid dehydratase activity
AA958_RS17485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA958_RS17505	COG2226	methyltransferase
AA958_RS17510	COG0398	Pfam SNARE associated Golgi protein
AA958_RS17520	COG4134	Bacterial extracellular solute-binding protein
AA958_RS17530	COG4149	molybdate abc transporter
AA958_RS17535	COG3842	ATPase activity
AA958_RS17560	COG0717	Belongs to the dCTP deaminase family
AA958_RS17585	COG2181	nitrate reductase activity
AA958_RS17585	COG0247	lactate metabolic process
AA958_RS17590	COG0443	Heat shock 70 kDa protein
AA958_RS17595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA958_RS17600	COG0484	heat shock protein binding
AA958_RS17605	COG0789	Transcriptional regulator
AA958_RS17615	COG2197	response regulator
AA958_RS17635	COG0542	response to heat
AA958_RS17650	COG3844	kynureninase activity
AA958_RS17675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA958_RS17685	COG3293	Transposase
AA958_RS17695	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA958_RS17715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA958_RS17720	COG2226	methyltransferase
AA958_RS17725	COG3559	Exporter of polyketide antibiotics
AA958_RS17730	COG1131	(ABC) transporter
AA958_RS17750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA958_RS17790	COG0151	Belongs to the GarS family
AA958_RS17825	COG1902	pentaerythritol trinitrate reductase activity
AA958_RS17825	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA958_RS17830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA958_RS17835	COG1309	transcriptional regulator
AA958_RS17840	COG1082	Xylose isomerase domain protein TIM barrel
AA958_RS17845	COG0248	Ppx GppA phosphatase
AA958_RS17870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AA958_RS17880	COG0129	dihydroxy-acid dehydratase activity
AA958_RS17895	COG2814	Major facilitator Superfamily
AA958_RS17910	COG2409	Drug exporters of the RND superfamily
AA958_RS17915	COG1129	ABC transporter
AA958_RS17915	COG0842	Transport permease protein
AA958_RS17925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA958_RS17930	COG2197	response regulator
AA958_RS17940	COG4585	Histidine kinase
AA958_RS17950	COG0180	Tryptophanyl-tRNA synthetase
AA958_RS18010	COG0739	heme binding
AA958_RS18010	COG1196	nuclear chromosome segregation
AA958_RS18010	COG0741	lytic transglycosylase activity
AA958_RS18015	COG0671	phosphoesterase, PA-phosphatase related
AA958_RS18020	COG0277	FAD linked oxidase domain protein
AA958_RS18040	COG1937	Protein conserved in bacteria
AA958_RS18050	COG0306	phosphate transporter
AA958_RS18055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA958_RS18060	COG0581	inorganic phosphate transmembrane transporter activity
AA958_RS18080	COG0037	tRNA processing
AA958_RS18085	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AA958_RS18095	COG0302	gtp cyclohydrolase
AA958_RS18100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA958_RS18110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA958_RS18125	COG0649	NAD binding
AA958_RS18175	COG1174	glycine betaine transport
AA958_RS18185	COG1125	glycine betaine transport
AA958_RS18185	COG0517	IMP dehydrogenase activity
AA958_RS18200	COG2197	response regulator
AA958_RS18205	COG0640	Transcriptional regulator
AA958_RS18220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA958_RS18225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA958_RS18235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AA958_RS18255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AA958_RS18275	COG0657	acetylesterase activity
AA958_RS18290	COG0300	oxidoreductase activity
AA958_RS18310	COG0346	lactoylglutathione lyase activity
AA958_RS18315	COG1194	a g-specific adenine glycosylase
AA958_RS18325	COG2197	response regulator
AA958_RS18330	COG3851	Histidine kinase
AA958_RS18340	COG1131	(ABC) transporter
AA958_RS18360	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA958_RS18365	COG0047	phosphoribosylformylglycinamidine synthase activity
AA958_RS18370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA958_RS18425	COG1335	isochorismatase
AA958_RS18450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA958_RS18455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA958_RS18465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA958_RS18490	COG1643	Atp-dependent helicase
AA958_RS18530	COG1404	Belongs to the peptidase S8 family
AA958_RS18545	COG5297	Belongs to the glycosyl hydrolase family 6
AA958_RS18555	COG1595	DNA-templated transcription, initiation
AA958_RS18560	COG2409	Drug exporters of the RND superfamily
AA958_RS18570	COG3265	gluconokinase activity
AA958_RS18575	COG2610	gluconate transmembrane transporter activity
AA958_RS18595	COG2226	methyltransferase
AA958_RS18600	COG2318	DinB family
AA958_RS18610	COG0142	geranyltranstransferase activity
AA958_RS18615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA958_RS18655	COG1522	sequence-specific DNA binding
AA958_RS18660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AA958_RS18665	COG1687	branched-chain amino acid
AA958_RS18670	COG1082	Xylose isomerase domain protein TIM barrel
AA958_RS18730	COG1061	Type III restriction enzyme res subunit
AA958_RS18750	COG0482	sulfurtransferase activity
AA958_RS18915	COG0714	Associated with various cellular activities
AA958_RS18995	COG1388	LysM domain
AA958_RS18995	COG3103	Sh3 type 3 domain protein
AA958_RS18995	COG0791	NLP P60 protein
AA958_RS19095	COG4974	Belongs to the 'phage' integrase family
AA958_RS19165	COG1725	Transcriptional regulator
AA958_RS19175	COG4249	Peptidase C14 caspase catalytic subunit p20
AA958_RS19175	COG2319	Wd-40 repeat
AA958_RS19185	COG2319	Wd-40 repeat
AA958_RS19185	COG4249	Peptidase C14 caspase catalytic subunit p20
AA958_RS19275	COG0124	histidyl-tRNA synthetase
AA958_RS19290	COG2319	Wd-40 repeat
AA958_RS19290	COG4249	Peptidase C14 caspase catalytic subunit p20
AA958_RS19320	COG4974	Belongs to the 'phage' integrase family
AA958_RS19340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA958_RS19425	COG2018	Roadblock/LC7 domain
AA958_RS19445	COG1960	acyl-CoA dehydrogenase activity
AA958_RS19455	COG0596	Alpha beta hydrolase
AA958_RS19540	COG4977	sequence-specific DNA binding
AA958_RS19560	COG0443	Heat shock 70 kDa protein
AA958_RS19580	COG3903	Transcriptional regulator
AA958_RS19580	COG3629	intracellular signal transduction
AA958_RS19615	COG1131	(ABC) transporter
AA958_RS19635	COG1473	amidohydrolase
AA958_RS19700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AA958_RS19730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA958_RS19740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA958_RS19760	COG0596	Alpha beta hydrolase
AA958_RS19775	COG0463	Glycosyl transferase, family 2
AA958_RS19790	COG1278	Cold shock
AA958_RS19800	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA958_RS19805	COG1737	Transcriptional regulator
AA958_RS19855	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA958_RS19860	COG1609	Transcriptional regulator
AA958_RS19875	COG1175	transmembrane transport
AA958_RS19880	COG0395	ABC-type sugar transport system, permease component
AA958_RS19890	COG1129	ABC transporter
AA958_RS19895	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA958_RS19905	COG1070	Carbohydrate kinase
AA958_RS19940	COG3973	AAA domain
AA958_RS19950	COG0515	serine threonine protein kinase
AA958_RS19950	COG2815	serine threonine protein kinase
AA958_RS19955	COG1247	-acetyltransferase
AA958_RS19995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA958_RS20080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA958_RS20085	COG0579	oxidoreductase
AA958_RS20145	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA958_RS20190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AA958_RS20195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA958_RS20200	COG0181	hydroxymethylbilane synthase activity
AA958_RS20205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA958_RS20205	COG1648	precorrin-2 dehydrogenase activity
AA958_RS20210	COG0113	porphobilinogen synthase activity
AA958_RS20220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA958_RS20240	COG0018	arginyl-trna synthetase
AA958_RS20245	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AA958_RS20265	COG0406	alpha-ribazole phosphatase activity
AA958_RS20270	COG3387	PFAM Glycoside hydrolase 15-related
AA958_RS20320	COG4977	sequence-specific DNA binding
AA958_RS20325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA958_RS20345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA958_RS20350	COG1333	cytochrome c biogenesis protein
AA958_RS20355	COG0785	Cytochrome C biogenesis protein
AA958_RS20360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA958_RS20365	COG0406	alpha-ribazole phosphatase activity
AA958_RS20370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA958_RS20390	COG1278	Cold shock
AA958_RS20450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA958_RS20470	COG0163	prenyltransferase activity
AA958_RS20480	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA958_RS20495	COG1823	symporter activity
AA958_RS20545	COG1278	Cold shock
AA958_RS20550	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AA958_RS20560	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA958_RS20565	COG2226	methyltransferase
AA958_RS20585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS20590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS20595	COG0649	NAD binding
AA958_RS20605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AA958_RS20610	COG1034	ATP synthesis coupled electron transport
AA958_RS20615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA958_RS20620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS20625	COG0839	Belongs to the complex I subunit 6 family
AA958_RS20630	COG0713	ATP synthesis coupled electron transport
AA958_RS20635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA958_RS20645	COG1007	ATP synthesis coupled electron transport
AA958_RS20655	COG0142	geranyltranstransferase activity
AA958_RS20695	COG0702	epimerase
AA958_RS20700	COG1733	regulation of RNA biosynthetic process
AA958_RS20705	COG1013	pyruvate-flavodoxin oxidoreductase activity
AA958_RS20710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AA958_RS20710	COG0674	pyruvate-flavodoxin oxidoreductase activity
AA958_RS20720	COG4585	Histidine kinase
AA958_RS20725	COG4585	Histidine kinase
AA958_RS20730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS20735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS20740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS20745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA958_RS20750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS20755	COG0839	Belongs to the complex I subunit 6 family
AA958_RS20760	COG0713	ATP synthesis coupled electron transport
AA958_RS20765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA958_RS20775	COG1007	ATP synthesis coupled electron transport
AA958_RS20780	COG0501	Belongs to the peptidase M48B family
AA958_RS20800	COG0477	Major facilitator Superfamily
AA958_RS20815	COG2030	dehydratase
AA958_RS20820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA958_RS20840	COG0702	epimerase
AA958_RS20855	COG0346	lactoylglutathione lyase activity
AA958_RS20870	COG1959	2 iron, 2 sulfur cluster binding
AA958_RS20905	COG1666	GTP binding
AA958_RS20925	COG0604	alcohol dehydrogenase
AA958_RS20925	COG3321	synthase
AA958_RS20925	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS20960	COG2201	protein-glutamate methylesterase activity
AA958_RS20965	COG4585	Histidine kinase
AA958_RS20970	COG0586	Pfam SNARE associated Golgi protein
AA958_RS20975	COG1846	Transcriptional regulator
AA958_RS20985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA958_RS21000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA958_RS21005	COG0436	Aminotransferase
AA958_RS21025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA958_RS21030	COG0081	regulation of translation
AA958_RS21045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA958_RS21050	COG0222	ribosome binding
AA958_RS21055	COG0085	RNA polymerase activity
AA958_RS21060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA958_RS21070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AA958_RS21075	COG0049	tRNA binding
AA958_RS21080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA958_RS21085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA958_RS21125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA958_RS21130	COG1515	deoxyribonuclease V activity
AA958_RS21150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA958_RS21170	COG0051	transcription antitermination factor activity, RNA binding
AA958_RS21175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA958_RS21180	COG0088	Forms part of the polypeptide exit tunnel
AA958_RS21185	COG0089	rRNA binding
AA958_RS21190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA958_RS21195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA958_RS21200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA958_RS21205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA958_RS21210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA958_RS21215	COG0255	Belongs to the universal ribosomal protein uL29 family
AA958_RS21220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA958_RS21225	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA958_RS21230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA958_RS21235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AA958_RS21240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA958_RS21245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA958_RS21250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA958_RS21255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA958_RS21260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AA958_RS21265	COG1841	ribosomal large subunit assembly
AA958_RS21270	COG0200	Binds to the 23S rRNA
AA958_RS21280	COG0563	adenylate kinase activity
AA958_RS21290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA958_RS21295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AA958_RS21300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA958_RS21305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA958_RS21310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA958_RS21315	COG0202	RNA polymerase activity
AA958_RS21320	COG0203	ribosomal protein L17
AA958_RS21325	COG0101	tRNA pseudouridine synthase activity
AA958_RS21330	COG1472	Belongs to the glycosyl hydrolase 3 family
AA958_RS21345	COG0488	(ABC) transporter
AA958_RS21350	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA958_RS21355	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA958_RS21360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA958_RS21370	COG1072	(Pantothenic acid kinase))
AA958_RS21380	COG0736	holo-[acyl-carrier-protein] synthase activity
AA958_RS21390	COG2186	Transcriptional regulator
AA958_RS21405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA958_RS21415	COG0802	atpase or kinase
AA958_RS21440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA958_RS21460	COG0726	polysaccharide deacetylase
AA958_RS21465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA958_RS21475	COG0300	oxidoreductase activity
AA958_RS21480	COG2132	Multicopper oxidase
AA958_RS21490	COG0583	DNA-binding transcription factor activity
AA958_RS21505	COG1595	DNA-templated transcription, initiation
AA958_RS21515	COG0516	GMP reductase activity
AA958_RS21540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AA958_RS21565	COG0515	serine threonine protein kinase
AA958_RS21565	COG2815	serine threonine protein kinase
AA958_RS21570	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS21585	COG1309	transcriptional regulator
AA958_RS21610	COG0519	Catalyzes the synthesis of GMP from XMP
AA958_RS21610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA958_RS21640	COG2197	response regulator
AA958_RS21670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA958_RS21685	COG0714	Associated with various cellular activities
AA958_RS21690	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AA958_RS21695	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AA958_RS21700	COG0045	succinate-CoA ligase (ADP-forming) activity
AA958_RS21730	COG0138	bifunctional purine biosynthesis protein purh
AA958_RS21740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA958_RS21755	COG0039	L-malate dehydrogenase activity
AA958_RS21775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA958_RS21780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA958_RS21785	COG1408	metallophosphoesterase
AA958_RS21815	COG1686	Belongs to the peptidase S11 family
AA958_RS21830	COG0180	Tryptophanyl-tRNA synthetase
AA958_RS21835	COG1595	DNA-templated transcription, initiation
AA958_RS21850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA958_RS21855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA958_RS21865	COG0745	RESPONSE REGULATOR receiver
AA958_RS21895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA958_RS21900	COG0477	Major facilitator Superfamily
AA958_RS21915	COG1216	Glycosyl transferase, family 2
AA958_RS21925	COG1083	cytidylyl-transferase
AA958_RS21930	COG2089	acid synthase
AA958_RS21940	COG1473	amidohydrolase
AA958_RS21940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AA958_RS21970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA958_RS21970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA958_RS21985	COG1595	DNA-templated transcription, initiation
AA958_RS22015	COG2009	succinate dehydrogenase
AA958_RS22025	COG1053	succinate dehydrogenase
AA958_RS22030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA958_RS22055	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA958_RS22060	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA958_RS22065	COG3845	ABC transporter
AA958_RS22070	COG1744	ABC transporter substrate-binding protein PnrA-like
AA958_RS22075	COG2814	Major facilitator Superfamily
AA958_RS22080	COG0583	DNA-binding transcription factor activity
AA958_RS22090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA958_RS22120	COG2205	protein histidine kinase activity
AA958_RS22125	COG0745	RESPONSE REGULATOR receiver
AA958_RS22130	COG1595	DNA-templated transcription, initiation
AA958_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS22140	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS22170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA958_RS22205	COG4770	biotin carboxylase activity
AA958_RS22215	COG0424	maF-like protein
AA958_RS22225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA958_RS22235	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA958_RS22245	COG1024	Enoyl-CoA hydratase
AA958_RS22250	COG2986	histidine ammonia-lyase
AA958_RS22255	COG1376	ErfK ybiS ycfS ynhG family protein
AA958_RS22260	COG0577	efflux transmembrane transporter activity
AA958_RS22265	COG1136	(ABC) transporter
AA958_RS22290	COG4977	sequence-specific DNA binding
AA958_RS22310	COG2770	Histidine kinase
AA958_RS22310	COG2208	phosphoserine phosphatase activity
AA958_RS22330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA958_RS22360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA958_RS22375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA958_RS22385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA958_RS22395	COG2255	four-way junction helicase activity
AA958_RS22400	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AA958_RS22420	COG1309	transcriptional regulator
AA958_RS22425	COG1331	Highly conserved protein containing a thioredoxin domain
AA958_RS22455	COG1414	Transcriptional regulator
AA958_RS22460	COG0251	oxidation-reduction process
AA958_RS22465	COG4977	sequence-specific DNA binding
AA958_RS22500	COG2894	cell division
AA958_RS22545	COG2885	chlorophyll binding
AA958_RS22580	COG0667	Aldo Keto reductase
AA958_RS22585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA958_RS22590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AA958_RS22605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA958_RS22615	COG1136	(ABC) transporter
AA958_RS22655	COG0114	fumarate hydratase activity
AA958_RS22665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AA958_RS22665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AA958_RS22690	COG1722	exodeoxyribonuclease VII activity
AA958_RS22695	COG1570	exodeoxyribonuclease VII activity
AA958_RS22700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA958_RS22710	COG0012	GTP binding
AA958_RS22795	COG2326	polyphosphate kinase activity
AA958_RS22845	COG0501	Belongs to the peptidase M48B family
AA958_RS22900	COG0702	epimerase
AA958_RS22910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA958_RS22910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA958_RS22915	COG0730	response to heat
AA958_RS22920	COG1937	Protein conserved in bacteria
AA958_RS22930	COG3629	intracellular signal transduction
AA958_RS22930	COG3903	Transcriptional regulator
AA958_RS22950	COG2146	nitrite reductase [NAD(P)H] activity
AA958_RS22950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA958_RS22955	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA958_RS22960	COG0243	molybdopterin cofactor binding
AA958_RS22980	COG0488	(ABC) transporter
AA958_RS22990	COG1136	(ABC) transporter
AA958_RS22990	COG0577	efflux transmembrane transporter activity
AA958_RS23015	COG0681	Belongs to the peptidase S26 family
AA958_RS23020	COG1132	(ABC) transporter
AA958_RS23045	COG1136	(ABC) transporter
AA958_RS23055	COG0789	Transcriptional regulator
AA958_RS23070	COG2239	Acts as a magnesium transporter
AA958_RS23095	COG1842	Phage shock protein A
AA958_RS23105	COG2027	D-alanyl-D-alanine carboxypeptidase
AA958_RS23110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA958_RS23135	COG1217	gtp-binding protein TYPA
AA958_RS23145	COG0601	transmembrane transport
AA958_RS23150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA958_RS23155	COG0444	Belongs to the ABC transporter superfamily
AA958_RS23160	COG4608	Belongs to the ABC transporter superfamily
AA958_RS23180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA958_RS23195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA958_RS23200	COG0747	negative chemotaxis
AA958_RS23215	COG4608	Belongs to the ABC transporter superfamily
AA958_RS23225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA958_RS23225	COG0456	acetyltransferase
AA958_RS23250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA958_RS23255	COG1611	Belongs to the LOG family
AA958_RS23260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA958_RS23270	COG0519	Catalyzes the synthesis of GMP from XMP
AA958_RS23275	COG1024	Enoyl-CoA hydratase
AA958_RS23285	COG1595	DNA-templated transcription, initiation
AA958_RS23295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA958_RS23300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA958_RS23325	COG0598	Magnesium transport protein CorA
AA958_RS23340	COG0613	PHP domain protein
AA958_RS23345	COG2095	MarC family integral membrane protein
AA958_RS23360	COG0513	Belongs to the DEAD box helicase family
AA958_RS23445	COG0210	DNA helicase
AA958_RS23455	COG0210	DNA helicase
AA958_RS23460	COG2816	NAD+ diphosphatase activity
AA958_RS23490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA958_RS23525	COG3480	Lon protease (S16) C-terminal proteolytic domain
AA958_RS23535	COG1615	UPF0182 protein
AA958_RS23565	COG0483	inositol monophosphate 1-phosphatase activity
AA958_RS23575	COG2076	Multidrug Resistance protein
AA958_RS23580	COG1162	GTPase activity
AA958_RS23585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA958_RS23595	COG2135	peptidase activity
AA958_RS23605	COG1595	DNA-templated transcription, initiation
AA958_RS23610	COG5662	AntiSigma factor
AA958_RS23630	COG0242	peptide deformylase activity
AA958_RS23640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA958_RS23660	COG1966	Carbon starvation protein
AA958_RS23665	COG2188	Transcriptional regulator
AA958_RS23670	COG2182	Extracellular solute-binding protein
AA958_RS23675	COG1175	transmembrane transport
AA958_RS23680	COG0395	ABC-type sugar transport system, permease component
AA958_RS23685	COG1472	Belongs to the glycosyl hydrolase 3 family
AA958_RS23690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA958_RS23695	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS23700	COG1309	transcriptional regulator
AA958_RS23715	COG1597	lipid kinase activity
AA958_RS23745	COG5006	permease, DMT superfamily
AA958_RS23775	COG4941	Belongs to the sigma-70 factor family
AA958_RS23800	COG4106	trans-aconitate 2-methyltransferase activity
AA958_RS23810	COG0667	Aldo Keto reductase
AA958_RS23825	COG0765	amino acid transport
AA958_RS23830	COG1126	abc transporter atp-binding protein
AA958_RS23835	COG0604	alcohol dehydrogenase
AA958_RS23840	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
AA958_RS23860	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS23865	COG4585	Histidine kinase
AA958_RS23870	COG2197	response regulator
AA958_RS23930	COG2267	carboxylic ester hydrolase activity
AA958_RS23935	COG0567	Dehydrogenase, E1 component
AA958_RS23935	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA958_RS23940	COG2205	protein histidine kinase activity
AA958_RS23945	COG0745	RESPONSE REGULATOR receiver
AA958_RS23955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA958_RS23980	COG1846	Transcriptional regulator
AA958_RS23985	COG1846	Transcriptional regulator
AA958_RS24010	COG0791	NLP P60 protein
AA958_RS24030	COG0768	penicillin binding
AA958_RS24040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA958_RS24040	COG0519	Catalyzes the synthesis of GMP from XMP
AA958_RS24050	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS24055	COG0583	DNA-binding transcription factor activity
AA958_RS24060	COG1733	regulation of RNA biosynthetic process
AA958_RS24085	COG0477	Major facilitator Superfamily
AA958_RS24090	COG0384	phenazine biosynthesis protein PhzF
AA958_RS24095	COG1595	DNA-templated transcription, initiation
AA958_RS24135	COG4948	Mandelate Racemase Muconate Lactonizing
AA958_RS24140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA958_RS24145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA958_RS24155	COG1063	alcohol dehydrogenase
AA958_RS24160	COG0129	dihydroxy-acid dehydratase activity
AA958_RS24185	COG3467	pyridoxamine 5'-phosphate
AA958_RS24190	COG2409	Drug exporters of the RND superfamily
AA958_RS24195	COG4585	Histidine kinase
AA958_RS24200	COG2197	response regulator
AA958_RS24205	COG3903	Transcriptional regulator
AA958_RS24205	COG3629	intracellular signal transduction
AA958_RS24250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA958_RS24280	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AA958_RS24300	COG0439	Biotin carboxylase
AA958_RS24310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA958_RS24320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA958_RS24330	COG1595	DNA-templated transcription, initiation
AA958_RS24335	COG4106	trans-aconitate 2-methyltransferase activity
AA958_RS24340	COG1595	DNA-templated transcription, initiation
AA958_RS24370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA958_RS24380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA958_RS24385	COG3424	synthase
AA958_RS24395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA958_RS24405	COG2197	response regulator
AA958_RS24485	COG0181	hydroxymethylbilane synthase activity
AA958_RS24500	COG1309	transcriptional regulator
AA958_RS24530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA958_RS24540	COG1131	(ABC) transporter
AA958_RS24540	COG0842	Transport permease protein
AA958_RS24540	COG1716	ATPase activity
AA958_RS24550	COG0789	Transcriptional regulator
AA958_RS24585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AA958_RS24595	COG1397	ADP-ribosylglycohydrolase
AA958_RS24630	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA958_RS24650	COG0142	geranyltranstransferase activity
AA958_RS24655	COG3046	protein related to deoxyribodipyrimidine photolyase
AA958_RS24695	COG0189	ligase activity
AA958_RS24715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA958_RS24735	COG2814	Major facilitator Superfamily
AA958_RS24765	COG0745	RESPONSE REGULATOR receiver
AA958_RS24770	COG0018	arginyl-trna synthetase
AA958_RS24775	COG0019	diaminopimelate decarboxylase activity
AA958_RS24785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA958_RS24795	COG0083	homoserine kinase activity
AA958_RS24805	COG1316	TRANSCRIPTIONal
AA958_RS24810	COG0254	rRNA binding
AA958_RS24815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA958_RS24820	COG2890	protein-(glutamine-N5) methyltransferase activity
AA958_RS24830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA958_RS24850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA958_RS24855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA958_RS24860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA958_RS24865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AA958_RS24870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA958_RS24875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA958_RS24880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA958_RS24915	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AA958_RS24930	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA958_RS24950	COG4585	Histidine kinase
AA958_RS24955	COG2197	response regulator
AA958_RS24995	COG0183	Belongs to the thiolase family
AA958_RS25065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA958_RS25065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA958_RS25100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AA958_RS25105	COG0280	phosphate acetyltransferase
AA958_RS25105	COG0857	belongs to the CobB CobQ family
AA958_RS25110	COG0205	6-phosphofructokinase activity
AA958_RS25115	COG0667	Aldo Keto reductase
AA958_RS25135	COG0395	ABC-type sugar transport system, permease component
AA958_RS25140	COG1175	transmembrane transport
AA958_RS25150	COG4565	transcriptional regulatory protein
AA958_RS25155	COG3290	protein histidine kinase activity
AA958_RS25160	COG1301	dicarboxylic acid transport
AA958_RS25185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA958_RS25185	COG2755	lipolytic protein G-D-S-L family
AA958_RS25220	COG1309	transcriptional regulator
AA958_RS25245	COG1132	(ABC) transporter
AA958_RS25250	COG1132	(ABC) transporter
AA958_RS25255	COG1376	ErfK ybiS ycfS ynhG family protein
AA958_RS25310	COG1280	lysine exporter protein (LysE YggA)
AA958_RS25330	COG0583	DNA-binding transcription factor activity
AA958_RS25335	COG5640	endopeptidase activity
AA958_RS25370	COG1760	l-serine dehydratase
AA958_RS25375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA958_RS25380	COG0509	glycine decarboxylation via glycine cleavage system
AA958_RS25385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA958_RS25410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA958_RS25415	COG0747	negative chemotaxis
AA958_RS25425	COG0444	Belongs to the ABC transporter superfamily
AA958_RS25430	COG4608	Belongs to the ABC transporter superfamily
AA958_RS25435	COG2860	membrane
AA958_RS25450	COG0482	sulfurtransferase activity
AA958_RS25460	COG4221	oxidoreductase activity
AA958_RS25470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA958_RS25480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA958_RS25485	COG0154	amidase activity
AA958_RS25495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA958_RS25500	COG2409	Drug exporters of the RND superfamily
AA958_RS25510	COG1672	PFAM Archaeal ATPase
AA958_RS25510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA958_RS25520	COG2197	response regulator
AA958_RS25525	COG2197	response regulator
AA958_RS25530	COG1672	PFAM Archaeal ATPase
AA958_RS25530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AA958_RS25535	COG2133	pyrroloquinoline quinone binding
AA958_RS25540	COG0667	Aldo Keto reductase
AA958_RS25560	COG0440	acetolactate synthase activity
AA958_RS25565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA958_RS25570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA958_RS25590	COG0506	proline dehydrogenase activity
AA958_RS25595	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS25600	COG0069	glutamate synthase activity
AA958_RS25615	COG0473	3-isopropylmalate dehydrogenase activity
AA958_RS25620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA958_RS25630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA958_RS25645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA958_RS25655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA958_RS25660	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA958_RS25675	COG2018	Roadblock/LC7 domain
AA958_RS25695	COG2018	Roadblock/LC7 domain
AA958_RS25725	COG1414	Transcriptional regulator
AA958_RS25730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA958_RS25735	COG0066	3-isopropylmalate dehydratase activity
AA958_RS25745	COG0776	regulation of translation
AA958_RS25755	COG1920	GTP binding
AA958_RS25765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA958_RS25770	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA958_RS25790	COG0351	phosphomethylpyrimidine kinase
AA958_RS25795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA958_RS25800	COG1461	Dihydroxyacetone kinase
AA958_RS25810	COG0326	Molecular chaperone. Has ATPase activity
AA958_RS25820	COG0742	ribosomal rna small subunit methyltransferase
AA958_RS25825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA958_RS25840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA958_RS25845	COG0571	ribonuclease III activity
AA958_RS25850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA958_RS25855	COG2340	Cysteine-rich secretory protein family
AA958_RS25860	COG1254	Belongs to the acylphosphatase family
AA958_RS25870	COG1196	nuclear chromosome segregation
AA958_RS25900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AA958_RS25910	COG0442	prolyl-tRNA aminoacylation
AA958_RS25920	COG0228	four-way junction DNA binding
AA958_RS25925	COG1837	Belongs to the UPF0109 family
AA958_RS25930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA958_RS25935	COG0336	Belongs to the RNA methyltransferase TrmD family
AA958_RS25940	COG0335	large ribosomal subunit rRNA binding
AA958_RS25945	COG0681	Belongs to the peptidase S26 family
AA958_RS25955	COG0681	Belongs to the peptidase S26 family
AA958_RS25970	COG0792	nuclease activity
AA958_RS25985	COG1191	sigma factor activity
AA958_RS26000	COG0052	Belongs to the universal ribosomal protein uS2 family
AA958_RS26005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA958_RS26010	COG0528	UMP kinase activity
AA958_RS26015	COG0233	cytoplasmic translational termination
AA958_RS26020	COG0575	Belongs to the CDS family
AA958_RS26025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA958_RS26035	COG1177	transmembrane transport
AA958_RS26040	COG3842	ATPase activity
AA958_RS26045	COG1136	(ABC) transporter
AA958_RS26045	COG0577	efflux transmembrane transporter activity
AA958_RS26050	COG0577	efflux transmembrane transporter activity
AA958_RS26050	COG1136	(ABC) transporter
AA958_RS26065	COG0745	RESPONSE REGULATOR receiver
AA958_RS26070	COG2205	protein histidine kinase activity
AA958_RS26080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA958_RS26090	COG1136	(ABC) transporter
AA958_RS26095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA958_RS26100	COG1522	sequence-specific DNA binding
AA958_RS26105	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS26125	COG3842	ATPase activity
AA958_RS26130	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA958_RS26135	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA958_RS26140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA958_RS26160	COG0477	Major facilitator Superfamily
AA958_RS26170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA958_RS26205	COG1595	DNA-templated transcription, initiation
AA958_RS26215	COG2508	Transcriptional regulator
AA958_RS26225	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS26235	COG0640	Transcriptional regulator
AA958_RS26240	COG0730	response to heat
AA958_RS26245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AA958_RS26250	COG0750	zinc metalloprotease
AA958_RS26255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA958_RS26270	COG0442	prolyl-tRNA aminoacylation
AA958_RS26290	COG0779	Required for maturation of 30S ribosomal subunits
AA958_RS26305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA958_RS26315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA958_RS26320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA958_RS26335	COG4608	Belongs to the ABC transporter superfamily
AA958_RS26340	COG0444	Belongs to the ABC transporter superfamily
AA958_RS26345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA958_RS26350	COG0601	transmembrane transport
AA958_RS26355	COG0747	negative chemotaxis
AA958_RS26360	COG0455	bacterial-type flagellum organization
AA958_RS26370	COG0515	serine threonine protein kinase
AA958_RS26370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS26385	COG0741	lytic transglycosylase activity
AA958_RS26385	COG1196	nuclear chromosome segregation
AA958_RS26385	COG0739	heme binding
AA958_RS26390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA958_RS26395	COG1185	polyribonucleotide nucleotidyltransferase activity
AA958_RS26400	COG0612	Peptidase, M16
AA958_RS26405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA958_RS26425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA958_RS26430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AA958_RS26450	COG2770	Histidine kinase
AA958_RS26450	COG2208	phosphoserine phosphatase activity
AA958_RS26455	COG3437	response regulator, receiver
AA958_RS26455	COG4999	Histidine kinase
AA958_RS26455	COG2205	protein histidine kinase activity
AA958_RS26455	COG3850	Histidine kinase
AA958_RS26465	COG1674	ftsk spoiiie
AA958_RS26475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA958_RS26485	COG1546	Belongs to the CinA family
AA958_RS26485	COG1058	Belongs to the CinA family
AA958_RS26490	COG1396	sequence-specific DNA binding
AA958_RS26495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA958_RS26510	COG1201	RNA secondary structure unwinding
AA958_RS26515	COG2207	Transcriptional regulator
AA958_RS26515	COG1917	Cupin 2, conserved barrel domain protein
AA958_RS26545	COG2205	protein histidine kinase activity
AA958_RS26550	COG0745	RESPONSE REGULATOR receiver
AA958_RS26555	COG1126	abc transporter atp-binding protein
AA958_RS26560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA958_RS26565	COG0765	amino acid transport
AA958_RS26570	COG0765	amino acid transport
AA958_RS26575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA958_RS26580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AA958_RS26590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA958_RS26605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA958_RS26610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA958_RS26620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA958_RS26635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA958_RS26660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA958_RS26670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA958_RS26675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA958_RS26680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA958_RS26685	COG0583	DNA-binding transcription factor activity
AA958_RS26710	COG1309	transcriptional regulator
AA958_RS26715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA958_RS26755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA958_RS26760	COG2186	Transcriptional regulator
AA958_RS26770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA958_RS26795	COG0187	DNA topoisomerase II activity
AA958_RS26810	COG0366	Alpha amylase catalytic
AA958_RS26815	COG0395	ABC-type sugar transport system, permease component
AA958_RS26820	COG1175	transmembrane transport
AA958_RS26840	COG3290	protein histidine kinase activity
AA958_RS26845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA958_RS26860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA958_RS26865	COG0612	Peptidase, M16
AA958_RS26875	COG1802	Transcriptional regulator
AA958_RS26880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA958_RS26925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA958_RS26935	COG0745	RESPONSE REGULATOR receiver
AA958_RS26940	COG2205	protein histidine kinase activity
AA958_RS26965	COG0756	dUTP diphosphatase activity
AA958_RS26975	COG0577	efflux transmembrane transporter activity
AA958_RS26975	COG1136	(ABC) transporter
AA958_RS26980	COG1136	(ABC) transporter
AA958_RS27010	COG0569	domain protein
AA958_RS27015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA958_RS27075	COG2208	phosphoserine phosphatase activity
AA958_RS27075	COG2770	Histidine kinase
AA958_RS27095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA958_RS27100	COG0569	domain protein
AA958_RS27120	COG2267	carboxylic ester hydrolase activity
AA958_RS27150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA958_RS27190	COG0174	glutamine synthetase
AA958_RS27195	COG2188	Transcriptional regulator
AA958_RS27200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA958_RS27205	COG3395	kinase activity
AA958_RS27225	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS27230	COG0640	Transcriptional regulator
AA958_RS27245	COG4585	Histidine kinase
AA958_RS27250	COG2197	response regulator
AA958_RS27260	COG0254	rRNA binding
AA958_RS27265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA958_RS27295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA958_RS27295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA958_RS27305	COG1802	Transcriptional regulator
AA958_RS27335	COG2755	lipolytic protein G-D-S-L family
AA958_RS27345	COG2188	Transcriptional regulator
AA958_RS27355	COG4213	ABC transporter substrate-binding protein
AA958_RS27360	COG1129	ABC transporter
AA958_RS27365	COG3547	Transposase (IS116 IS110 IS902 family)
AA958_RS27375	COG1070	Carbohydrate kinase
AA958_RS27380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA958_RS27385	COG0800	Aldolase
AA958_RS27415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA958_RS27420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AA958_RS27425	COG2080	2 iron, 2 sulfur cluster binding
AA958_RS27430	COG0514	ATP-dependent DNA helicase (RecQ)
AA958_RS27440	COG3938	Belongs to the proline racemase family
AA958_RS27455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA958_RS27485	COG2132	Multicopper oxidase
AA958_RS27550	COG3119	arylsulfatase activity
AA958_RS27595	COG0739	heme binding
AA958_RS27595	COG1196	nuclear chromosome segregation
AA958_RS27595	COG0741	lytic transglycosylase activity
AA958_RS27615	COG3540	Alkaline phosphatase
AA958_RS27620	COG1799	cell septum assembly
AA958_RS27630	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS27640	COG3629	intracellular signal transduction
AA958_RS27640	COG3903	Transcriptional regulator
AA958_RS27665	COG2040	homocysteine
AA958_RS27675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA958_RS27680	COG2235	arginine
AA958_RS27695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA958_RS27700	COG1024	Enoyl-CoA hydratase
AA958_RS27710	COG2267	carboxylic ester hydrolase activity
AA958_RS27755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AA958_RS27785	COG1653	transport
AA958_RS27790	COG1175	transmembrane transport
AA958_RS27795	COG0395	ABC-type sugar transport system, permease component
AA958_RS27800	COG1940	carbohydrate kinase activity
AA958_RS27805	COG4213	ABC transporter substrate-binding protein
AA958_RS27815	COG4214	carbohydrate transport
AA958_RS27820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA958_RS27830	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA958_RS27830	COG1024	Enoyl-CoA hydratase
AA958_RS27835	COG0183	Belongs to the thiolase family
AA958_RS27855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA958_RS27870	COG3253	May function as heme-dependent peroxidase
AA958_RS27885	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA958_RS27925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA958_RS27930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA958_RS27960	COG4214	carbohydrate transport
AA958_RS27970	COG4213	ABC transporter substrate-binding protein
AA958_RS27975	COG1349	DNA-binding transcription factor activity
AA958_RS28005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AA958_RS28010	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
AA958_RS28040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA958_RS28055	COG1132	(ABC) transporter
AA958_RS28095	COG2409	Drug exporters of the RND superfamily
AA958_RS28100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA958_RS28105	COG1116	anion transmembrane transporter activity
AA958_RS28115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA958_RS28120	COG1116	anion transmembrane transporter activity
AA958_RS28125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA958_RS28130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA958_RS28145	COG0175	sulfate reduction
AA958_RS28160	COG3284	Transcriptional regulator
AA958_RS28165	COG1960	acyl-CoA dehydrogenase activity
AA958_RS28175	COG1796	DNA polymerase
AA958_RS28175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AA958_RS28180	COG1162	GTPase activity
AA958_RS28185	COG1309	transcriptional regulator
AA958_RS28215	COG1802	Transcriptional regulator
AA958_RS28220	COG3458	cephalosporin-C deacetylase activity
AA958_RS28225	COG1609	Transcriptional regulator
AA958_RS28235	COG0673	inositol 2-dehydrogenase activity
AA958_RS28240	COG0583	DNA-binding transcription factor activity
AA958_RS28245	COG1522	sequence-specific DNA binding
AA958_RS28260	COG3835	regulator
AA958_RS28275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA958_RS28280	COG2252	PERMEase
AA958_RS28285	COG3608	succinylglutamate desuccinylase aspartoacylase
AA958_RS28285	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA958_RS28305	COG2264	protein methyltransferase activity
AA958_RS28315	COG2197	response regulator
AA958_RS28320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA958_RS28325	COG0318	PFAM AMP-dependent synthetase and ligase
AA958_RS28335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA958_RS28340	COG2197	response regulator
AA958_RS28355	COG3960	tartronate-semialdehyde synthase activity
AA958_RS28360	COG2084	Dehydrogenase
AA958_RS28365	COG3622	Belongs to the hyi family
AA958_RS28370	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AA958_RS28375	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA958_RS28385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA958_RS28395	COG2205	protein histidine kinase activity
AA958_RS28420	COG2351	hydroxyisourate hydrolase activity
AA958_RS28435	COG4821	SIS domain
AA958_RS28440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA958_RS28450	COG1414	Transcriptional regulator
AA958_RS28455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA958_RS28460	COG4266	Belongs to the allantoicase family
AA958_RS28465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AA958_RS28465	COG3291	Pkd domain containing protein
AA958_RS28475	COG0800	Aldolase
AA958_RS28485	COG2188	Transcriptional regulator
AA958_RS28505	COG1940	carbohydrate kinase activity
AA958_RS28560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA958_RS28570	COG1953	Uracil, thiamine, allantoin
AA958_RS28575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AA958_RS28580	COG0483	inositol monophosphate 1-phosphatase activity
AA958_RS28600	COG1929	Belongs to the glycerate kinase type-1 family
AA958_RS28620	COG0688	phosphatidylethanolamine metabolic process
AA958_RS28625	COG1960	acyl-CoA dehydrogenase activity
AA958_RS28635	COG2301	Belongs to the HpcH HpaI aldolase family
AA958_RS28640	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA958_RS28640	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AA958_RS28675	COG2362	D-Aminopeptidase
AA958_RS28680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA958_RS28685	COG1619	proteins homologs of microcin C7 resistance protein MccF
AA958_RS28720	COG2226	methyltransferase
AA958_RS28765	COG3119	arylsulfatase activity
AA958_RS28770	COG3119	arylsulfatase activity
AA958_RS28780	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA958_RS28785	COG2365	Tyrosine phosphatase family
AA958_RS28790	COG0656	L-ascorbic acid biosynthetic process
AA958_RS28820	COG3903	Transcriptional regulator
AA958_RS28820	COG3629	intracellular signal transduction
AA958_RS28835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA958_RS28840	COG1940	carbohydrate kinase activity
AA958_RS28845	COG1129	ABC transporter
AA958_RS28850	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA958_RS28855	COG4213	ABC transporter substrate-binding protein
AA958_RS28860	COG0673	inositol 2-dehydrogenase activity
AA958_RS28885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA958_RS28995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA958_RS29005	COG0443	Heat shock 70 kDa protein
AA958_RS29030	COG1140	nitrate reductase beta subunit
AA958_RS29055	COG1366	Belongs to the anti-sigma-factor antagonist family
AA958_RS29060	COG1366	Belongs to the anti-sigma-factor antagonist family
AA958_RS29085	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AA958_RS29090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA958_RS29100	COG0516	GMP reductase activity
AA958_RS29100	COG0517	IMP dehydrogenase activity
AA958_RS29120	COG0516	GMP reductase activity
AA958_RS29120	COG0517	IMP dehydrogenase activity
AA958_RS29145	COG0574	Belongs to the PEP-utilizing enzyme family
AA958_RS29145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA958_RS29185	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS29205	COG1012	belongs to the aldehyde dehydrogenase family
AA958_RS29210	COG1414	Transcriptional regulator
AA958_RS29235	COG0683	leucine binding
AA958_RS29250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA958_RS29255	COG3485	protocatechuate 3,4-dioxygenase
AA958_RS29260	COG3485	protocatechuate 3,4-dioxygenase
AA958_RS29265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AA958_RS29270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AA958_RS29295	COG0604	alcohol dehydrogenase
AA958_RS29295	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS29295	COG3321	synthase
AA958_RS29330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA958_RS29345	COG1620	l-lactate permease
AA958_RS29350	COG2186	Transcriptional regulator
AA958_RS29360	COG0640	Transcriptional regulator
AA958_RS29365	COG0640	Transcriptional regulator
AA958_RS29385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA958_RS29390	COG0573	inorganic phosphate transmembrane transporter activity
AA958_RS29395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA958_RS29400	COG0492	ferredoxin-NADP+ reductase activity
AA958_RS29405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA958_RS29415	COG0798	PFAM Bile acid sodium symporter
AA958_RS29420	COG0640	Transcriptional regulator
AA958_RS29445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA958_RS29465	COG0243	molybdopterin cofactor binding
AA958_RS29470	COG0504	CTP synthase activity
AA958_RS29480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA958_RS29485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA958_RS29490	COG0604	alcohol dehydrogenase
AA958_RS29490	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS29490	COG3321	synthase
AA958_RS29495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA958_RS29500	COG0028	Belongs to the TPP enzyme family
AA958_RS29500	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AA958_RS29505	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AA958_RS29510	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA958_RS29515	COG3639	organic phosphonate transmembrane transporter activity
AA958_RS29520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA958_RS29525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA958_RS29545	COG3707	response regulator
AA958_RS29550	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS29590	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS29625	COG3903	Transcriptional regulator
AA958_RS29625	COG3629	intracellular signal transduction
AA958_RS29670	COG0395	ABC-type sugar transport system, permease component
AA958_RS29675	COG3547	Transposase (IS116 IS110 IS902 family)
AA958_RS29695	COG1653	transport
AA958_RS29720	COG2207	Transcriptional regulator
AA958_RS29720	COG1609	Transcriptional regulator
AA958_RS29725	COG0673	inositol 2-dehydrogenase activity
AA958_RS29800	COG3507	Belongs to the glycosyl hydrolase 43 family
AA958_RS29810	COG1175	transmembrane transport
AA958_RS29820	COG1472	Belongs to the glycosyl hydrolase 3 family
AA958_RS29830	COG3693	PFAM glycoside hydrolase, family 10
AA958_RS29855	COG3875	lactate racemase activity
AA958_RS29860	COG2186	Transcriptional regulator
AA958_RS29885	COG0395	ABC-type sugar transport system, permease component
AA958_RS29890	COG4948	Mandelate Racemase Muconate Lactonizing
AA958_RS29900	COG3661	Belongs to the glycosyl hydrolase 67 family
AA958_RS29910	COG3345	alpha-galactosidase
AA958_RS29945	COG3387	PFAM Glycoside hydrolase 15-related
AA958_RS30025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA958_RS30065	COG0443	Heat shock 70 kDa protein
AA958_RS30080	COG0542	response to heat
AA958_RS30085	COG0515	serine threonine protein kinase
AA958_RS30140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA958_RS30155	COG2239	Acts as a magnesium transporter
AA958_RS30190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA958_RS30210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA958_RS30220	COG3903	Transcriptional regulator
AA958_RS30220	COG3629	intracellular signal transduction
AA958_RS30285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA958_RS30305	COG1595	DNA-templated transcription, initiation
AA958_RS30335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA958_RS30350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA958_RS30355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA958_RS30375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA958_RS30385	COG0745	RESPONSE REGULATOR receiver
AA958_RS30445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA958_RS30455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA958_RS30505	COG1228	amidohydrolase
AA958_RS30520	COG2133	pyrroloquinoline quinone binding
AA958_RS30520	COG5183	chlorophyll binding
AA958_RS30540	COG2197	response regulator
AA958_RS30545	COG2409	Drug exporters of the RND superfamily
AA958_RS30560	COG4941	Belongs to the sigma-70 factor family
AA958_RS30625	COG0477	Major facilitator Superfamily
AA958_RS30665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA958_RS30705	COG0248	Ppx GppA phosphatase
AA958_RS30710	COG0477	Major facilitator Superfamily
AA958_RS30800	COG1595	DNA-templated transcription, initiation
AA958_RS30815	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AA958_RS30820	COG1940	carbohydrate kinase activity
AA958_RS30860	COG0596	Alpha beta hydrolase
AA958_RS30875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA958_RS30890	COG0697	spore germination
AA958_RS30900	COG0477	Major facilitator Superfamily
AA958_RS30905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA958_RS30950	COG0488	(ABC) transporter
AA958_RS30970	COG2197	response regulator
AA958_RS31000	COG1175	transmembrane transport
AA958_RS31005	COG0395	ABC-type sugar transport system, permease component
AA958_RS31025	COG0395	ABC-type sugar transport system, permease component
AA958_RS31045	COG1609	Transcriptional regulator
AA958_RS31055	COG0277	FAD linked oxidase domain protein
AA958_RS31085	COG1131	(ABC) transporter
AA958_RS31100	COG0655	NAD(P)H dehydrogenase (quinone) activity
AA958_RS31105	COG1132	(ABC) transporter
AA958_RS31145	COG1129	ABC transporter
AA958_RS31170	COG3903	Transcriptional regulator
AA958_RS31170	COG3629	intracellular signal transduction
AA958_RS31185	COG1472	Belongs to the glycosyl hydrolase 3 family
AA958_RS31200	COG0019	diaminopimelate decarboxylase activity
AA958_RS31225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA958_RS31235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA958_RS31245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA958_RS31270	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA958_RS31275	COG2267	carboxylic ester hydrolase activity
AA958_RS31310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA958_RS31340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AA958_RS31355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA958_RS31370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA958_RS31375	COG1414	Transcriptional regulator
AA958_RS31380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA958_RS31385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA958_RS31385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA958_RS31395	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AA958_RS31400	COG1082	Xylose isomerase domain protein TIM barrel
AA958_RS31405	COG1063	alcohol dehydrogenase
AA958_RS31415	COG1175	transmembrane transport
AA958_RS31420	COG0395	ABC-type sugar transport system, permease component
AA958_RS31425	COG1846	Transcriptional regulator
AA958_RS31425	COG1940	carbohydrate kinase activity
AA958_RS31440	COG0515	serine threonine protein kinase
AA958_RS31440	COG2815	serine threonine protein kinase
AA958_RS31455	COG1446	asparaginase
AA958_RS31460	COG5006	permease, DMT superfamily
AA958_RS31465	COG0583	DNA-binding transcription factor activity
AA958_RS31475	COG1404	Belongs to the peptidase S8 family
AA958_RS31480	COG2197	response regulator
AA958_RS31485	COG1404	Belongs to the peptidase S8 family
AA958_RS31490	COG1132	(ABC) transporter
AA958_RS31500	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS31570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA958_RS31580	COG0584	glycerophosphoryl diester phosphodiesterase
AA958_RS31585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA958_RS31590	COG0667	Aldo Keto reductase
AA958_RS31645	COG1940	carbohydrate kinase activity
AA958_RS31645	COG1846	Transcriptional regulator
AA958_RS31655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA958_RS31695	COG1609	Transcriptional regulator
AA958_RS31700	COG1653	transport
AA958_RS31705	COG1175	transmembrane transport
AA958_RS31710	COG0395	ABC-type sugar transport system, permease component
AA958_RS31715	COG1472	Belongs to the glycosyl hydrolase 3 family
AA958_RS31730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA958_RS31760	COG1366	Belongs to the anti-sigma-factor antagonist family
AA958_RS31765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA958_RS31770	COG3119	arylsulfatase activity
AA958_RS31780	COG0583	DNA-binding transcription factor activity
AA958_RS31785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA958_RS31795	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA958_RS31810	COG3275	phosphorelay sensor kinase activity
AA958_RS31820	COG1132	(ABC) transporter
AA958_RS31830	COG1595	DNA-templated transcription, initiation
AA958_RS31870	COG3424	synthase
AA958_RS31875	COG1024	Enoyl-CoA hydratase
AA958_RS31880	COG1024	Enoyl-CoA hydratase
AA958_RS31890	COG0745	RESPONSE REGULATOR receiver
AA958_RS31895	COG2205	protein histidine kinase activity
AA958_RS31905	COG1132	(ABC) transporter
AA958_RS31930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA958_RS31935	COG2124	cytochrome p450
AA958_RS31940	COG2124	cytochrome p450
AA958_RS31960	COG1136	(ABC) transporter
AA958_RS31960	COG0577	efflux transmembrane transporter activity
AA958_RS31965	COG0577	efflux transmembrane transporter activity
AA958_RS31970	COG0745	RESPONSE REGULATOR receiver
AA958_RS31975	COG2205	protein histidine kinase activity
AA958_RS32000	COG1793	dna ligase
AA958_RS32050	COG3268	Saccharopine dehydrogenase
AA958_RS32055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA958_RS32060	COG1960	acyl-CoA dehydrogenase activity
AA958_RS32065	COG0183	Belongs to the thiolase family
AA958_RS32070	COG1024	Enoyl-CoA hydratase
AA958_RS32070	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA958_RS32080	COG0789	Transcriptional regulator
AA958_RS32110	COG1280	lysine exporter protein (LysE YggA)
AA958_RS32115	COG2183	response to ionizing radiation
AA958_RS32125	COG1024	Enoyl-CoA hydratase
AA958_RS32130	COG0488	(ABC) transporter
AA958_RS32140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AA958_RS32165	COG0371	Dehydrogenase
AA958_RS32185	COG1134	teichoic acid transport
AA958_RS32185	COG1388	LysM domain
AA958_RS32190	COG2409	Drug exporters of the RND superfamily
AA958_RS32200	COG1562	ergosterol biosynthetic process
AA958_RS32210	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AA958_RS32220	COG1657	PFAM Prenyltransferase squalene oxidase
AA958_RS32235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA958_RS32295	COG3540	Alkaline phosphatase
AA958_RS32305	COG2267	carboxylic ester hydrolase activity
AA958_RS32315	COG3958	Transketolase
AA958_RS32320	COG3959	Transketolase, thiamine diphosphate binding domain
AA958_RS32330	COG3119	arylsulfatase activity
AA958_RS32350	COG1609	Transcriptional regulator
AA958_RS32360	COG0783	Belongs to the Dps family
AA958_RS32370	COG0405	Gamma-glutamyltransferase
AA958_RS32375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA958_RS32380	COG2964	Protein conserved in bacteria
AA958_RS32395	COG1024	Enoyl-CoA hydratase
AA958_RS32405	COG0515	serine threonine protein kinase
AA958_RS32410	COG1793	dna ligase
AA958_RS32475	COG0723	plastoquinol--plastocyanin reductase activity
AA958_RS32505	COG2409	Drug exporters of the RND superfamily
AA958_RS32510	COG2205	protein histidine kinase activity
AA958_RS32515	COG0745	RESPONSE REGULATOR receiver
AA958_RS32525	COG0477	Major facilitator Superfamily
AA958_RS32535	COG0697	spore germination
AA958_RS32555	COG1136	(ABC) transporter
AA958_RS32620	COG0346	lactoylglutathione lyase activity
AA958_RS32650	COG3547	Transposase (IS116 IS110 IS902 family)
AA958_RS32670	COG2329	Antibiotic biosynthesis monooxygenase
AA958_RS32675	COG1595	DNA-templated transcription, initiation
AA958_RS32685	COG2356	endonuclease I
AA958_RS32710	COG2080	2 iron, 2 sulfur cluster binding
AA958_RS32715	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AA958_RS32720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA958_RS32725	COG0300	oxidoreductase activity
AA958_RS32745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA958_RS32750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA958_RS32840	COG1982	Orn Lys Arg decarboxylase major
AA958_RS32845	COG0028	Belongs to the TPP enzyme family
AA958_RS32880	COG2770	Histidine kinase
AA958_RS32880	COG2208	phosphoserine phosphatase activity
AA958_RS32910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS32910	COG0515	serine threonine protein kinase
AA958_RS32920	COG1960	acyl-CoA dehydrogenase activity
AA958_RS32925	COG1024	Enoyl-CoA hydratase
AA958_RS32935	COG1960	acyl-CoA dehydrogenase activity
AA958_RS33000	COG0386	Belongs to the glutathione peroxidase family
AA958_RS33035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA958_RS33070	COG0019	diaminopimelate decarboxylase activity
AA958_RS33075	COG4264	IucA IucC family
AA958_RS33090	COG0738	Major facilitator superfamily
AA958_RS33105	COG3547	Transposase (IS116 IS110 IS902 family)
AA958_RS33115	COG4585	Histidine kinase
AA958_RS33120	COG2197	response regulator
AA958_RS33135	COG1695	Transcriptional regulator
AA958_RS33155	COG0456	acetyltransferase
AA958_RS33160	COG0435	Glutathione S-transferase
AA958_RS33195	COG2207	Transcriptional regulator
AA958_RS33195	COG0662	Cupin 2, conserved barrel domain protein
AA958_RS33215	COG3291	Pkd domain containing protein
AA958_RS33215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AA958_RS33220	COG3540	Alkaline phosphatase
AA958_RS33225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA958_RS33235	COG1921	L-seryl-tRNASec selenium transferase activity
AA958_RS33280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA958_RS33285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA958_RS33290	COG2301	Belongs to the HpcH HpaI aldolase family
AA958_RS33295	COG2838	Isocitrate dehydrogenase
AA958_RS33330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA958_RS33355	COG3201	nicotinamide mononucleotide transporter
AA958_RS33365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA958_RS33370	COG0140	phosphoribosyl-ATP diphosphatase activity
AA958_RS33375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA958_RS33420	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS33430	COG1960	acyl-CoA dehydrogenase activity
AA958_RS33440	COG1522	sequence-specific DNA binding
AA958_RS33445	COG1228	amidohydrolase
AA958_RS33450	COG1216	Glycosyl transferase, family 2
AA958_RS33465	COG2364	Membrane
AA958_RS33470	COG2186	Transcriptional regulator
AA958_RS33525	COG0395	ABC-type sugar transport system, permease component
AA958_RS33530	COG1175	transmembrane transport
AA958_RS33540	COG0673	inositol 2-dehydrogenase activity
AA958_RS33550	COG1414	Transcriptional regulator
AA958_RS33555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA958_RS33560	COG4948	Mandelate Racemase Muconate Lactonizing
AA958_RS33570	COG1028	Short-chain dehydrogenase reductase Sdr
AA958_RS33585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA958_RS33600	COG1063	alcohol dehydrogenase
AA958_RS33630	COG0402	S-adenosylhomocysteine deaminase activity
AA958_RS33650	COG1309	transcriptional regulator
AA958_RS33680	COG0587	DNA-directed DNA polymerase activity
AA958_RS33700	COG0477	Major facilitator Superfamily
AA958_RS33710	COG2223	nitrite transmembrane transporter activity
AA958_RS33715	COG2207	Transcriptional regulator
AA958_RS33730	COG3250	beta-galactosidase activity
AA958_RS33785	COG0583	DNA-binding transcription factor activity
AA958_RS33805	COG4221	oxidoreductase activity
AA958_RS33820	COG2272	Belongs to the type-B carboxylesterase lipase family
AA958_RS33860	COG1335	isochorismatase
AA958_RS33875	COG0702	epimerase
AA958_RS33880	COG2066	Belongs to the glutaminase family
AA958_RS33905	COG0747	negative chemotaxis
AA958_RS33910	COG0601	transmembrane transport
AA958_RS33915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA958_RS33925	COG4608	Belongs to the ABC transporter superfamily
AA958_RS33935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AA958_RS33950	COG1595	DNA-templated transcription, initiation
AA958_RS33970	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AA958_RS33975	COG0395	ABC-type sugar transport system, permease component
AA958_RS33980	COG1175	transmembrane transport
AA958_RS33995	COG5492	domain, Protein
AA958_RS34040	COG0277	FAD linked oxidase domain protein
AA958_RS34040	COG0247	lactate metabolic process
AA958_RS34045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA958_RS34100	COG2508	Transcriptional regulator
AA958_RS34135	COG0445	tRNA wobble uridine modification
AA958_RS34145	COG1175	transmembrane transport
AA958_RS34150	COG0395	ABC-type sugar transport system, permease component
AA958_RS34320	COG0443	Heat shock 70 kDa protein
AA958_RS34350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS34350	COG0515	serine threonine protein kinase
AA958_RS34420	COG0583	DNA-binding transcription factor activity
AA958_RS34425	COG2815	serine threonine protein kinase
AA958_RS34425	COG0515	serine threonine protein kinase
AA958_RS34435	COG3764	Sortase (surface protein transpeptidase)
AA958_RS34550	COG2226	methyltransferase
AA958_RS34585	COG0596	Alpha beta hydrolase
AA958_RS34625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA958_RS34640	COG3629	intracellular signal transduction
AA958_RS34640	COG3903	Transcriptional regulator
AA958_RS34650	COG0443	Heat shock 70 kDa protein
AA958_RS34655	COG0515	serine threonine protein kinase
AA958_RS34655	COG2815	serine threonine protein kinase
AA958_RS34660	COG0515	serine threonine protein kinase
AA958_RS34660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS34665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA958_RS34665	COG0515	serine threonine protein kinase
AA958_RS34675	COG0515	serine threonine protein kinase
AA958_RS34675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane