locus-tag	class	description
NNW99_RS00090	COG2205	protein histidine kinase activity
NNW99_RS00090	COG3437	response regulator, receiver
NNW99_RS00090	COG3850	Histidine kinase
NNW99_RS00090	COG4999	Histidine kinase
NNW99_RS00115	COG4249	Peptidase C14 caspase catalytic subunit p20
NNW99_RS00115	COG2319	Wd-40 repeat
NNW99_RS00125	COG3739	integral membrane protein
NNW99_RS00145	COG2353	YceI-like domain
NNW99_RS00155	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS00190	COG2301	Belongs to the HpcH HpaI aldolase family
NNW99_RS00195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNW99_RS00220	COG0747	negative chemotaxis
NNW99_RS00235	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS00245	COG2329	Antibiotic biosynthesis monooxygenase
NNW99_RS00260	COG2723	6-phospho-beta-galactosidase activity
NNW99_RS00290	COG3290	protein histidine kinase activity
NNW99_RS00305	COG0596	Alpha beta hydrolase
NNW99_RS00375	COG1136	(ABC) transporter
NNW99_RS00390	COG0154	amidase activity
NNW99_RS00425	COG0725	ABC transporter, periplasmic molybdate-binding protein
NNW99_RS00490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NNW99_RS00495	COG4521	taurine ABC transporter
NNW99_RS00505	COG2175	clavaminate synthase activity
NNW99_RS00520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NNW99_RS00530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS00555	COG2197	response regulator
NNW99_RS00565	COG1846	Transcriptional regulator
NNW99_RS00570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NNW99_RS00575	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS00585	COG1309	transcriptional regulator
NNW99_RS00590	COG0179	Fumarylacetoacetate (FAA) hydrolase
NNW99_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS00605	COG4689	acetoacetate decarboxylase
NNW99_RS00620	COG0174	glutamine synthetase
NNW99_RS00630	COG2267	carboxylic ester hydrolase activity
NNW99_RS00635	COG0436	Aminotransferase
NNW99_RS00645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NNW99_RS00645	COG0473	3-isopropylmalate dehydrogenase activity
NNW99_RS00650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NNW99_RS00655	COG0583	DNA-binding transcription factor activity
NNW99_RS00665	COG0789	Transcriptional regulator
NNW99_RS00670	COG0598	Magnesium transport protein CorA
NNW99_RS00675	COG0598	Magnesium transport protein CorA
NNW99_RS00690	COG1120	ATPase activity
NNW99_RS00695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS00705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NNW99_RS00710	COG1535	isochorismatase
NNW99_RS00710	COG3433	isochorismatase activity
NNW99_RS00775	COG3158	transport of potassium into the cell
NNW99_RS00800	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NNW99_RS00805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NNW99_RS00810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NNW99_RS00820	COG0531	amino acid
NNW99_RS00825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NNW99_RS00835	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NNW99_RS00850	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NNW99_RS00860	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NNW99_RS00875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NNW99_RS00905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NNW99_RS00915	COG3800	Transcriptional regulator
NNW99_RS00915	COG1396	sequence-specific DNA binding
NNW99_RS00950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NNW99_RS00965	COG2084	Dehydrogenase
NNW99_RS00970	COG3395	kinase activity
NNW99_RS00975	COG0235	Class ii aldolase
NNW99_RS00980	COG2271	Major facilitator Superfamily
NNW99_RS00985	COG3622	Belongs to the hyi family
NNW99_RS00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NNW99_RS00995	COG2186	Transcriptional regulator
NNW99_RS01000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNW99_RS01005	COG0738	Major facilitator superfamily
NNW99_RS01010	COG1132	(ABC) transporter
NNW99_RS01035	COG0583	DNA-binding transcription factor activity
NNW99_RS01055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NNW99_RS01060	COG1116	anion transmembrane transporter activity
NNW99_RS01065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NNW99_RS01070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS01075	COG0277	FAD linked oxidase domain protein
NNW99_RS01085	COG0395	ABC-type sugar transport system, permease component
NNW99_RS01090	COG1175	transmembrane transport
NNW99_RS01110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS01120	COG0431	NADPH-dependent FMN reductase
NNW99_RS01130	COG0583	DNA-binding transcription factor activity
NNW99_RS01150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NNW99_RS01155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NNW99_RS01165	COG0436	Aminotransferase
NNW99_RS01185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NNW99_RS01190	COG0477	Major facilitator Superfamily
NNW99_RS01195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NNW99_RS01200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NNW99_RS01215	COG2080	2 iron, 2 sulfur cluster binding
NNW99_RS01220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NNW99_RS01225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NNW99_RS01270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NNW99_RS01275	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS01280	COG3321	synthase
NNW99_RS01280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NNW99_RS01310	COG0667	Aldo Keto reductase
NNW99_RS01325	COG2814	Major facilitator Superfamily
NNW99_RS01330	COG3973	AAA domain
NNW99_RS01335	COG0673	inositol 2-dehydrogenase activity
NNW99_RS01385	COG0395	ABC-type sugar transport system, permease component
NNW99_RS01390	COG1175	transmembrane transport
NNW99_RS01400	COG1940	carbohydrate kinase activity
NNW99_RS01475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NNW99_RS01495	COG1846	Transcriptional regulator
NNW99_RS01495	COG1940	carbohydrate kinase activity
NNW99_RS01500	COG1175	transmembrane transport
NNW99_RS01520	COG1376	ErfK ybiS ycfS ynhG family protein
NNW99_RS01530	COG0583	DNA-binding transcription factor activity
NNW99_RS01540	COG4221	oxidoreductase activity
NNW99_RS01555	COG1132	(ABC) transporter
NNW99_RS01575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NNW99_RS01585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NNW99_RS01610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NNW99_RS01620	COG2130	NADP-dependent
NNW99_RS01680	COG0515	serine threonine protein kinase
NNW99_RS01690	COG1132	(ABC) transporter
NNW99_RS01700	COG2197	response regulator
NNW99_RS01730	COG2274	protein secretion by the type I secretion system
NNW99_RS01745	COG0248	Ppx GppA phosphatase
NNW99_RS01760	COG2890	protein-(glutamine-N5) methyltransferase activity
NNW99_RS01825	COG3250	beta-galactosidase activity
NNW99_RS01855	COG0667	Aldo Keto reductase
NNW99_RS01885	COG2124	cytochrome p450
NNW99_RS01905	COG0435	Glutathione S-transferase
NNW99_RS01915	COG1522	sequence-specific DNA binding
NNW99_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS02020	COG1796	DNA polymerase
NNW99_RS02020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NNW99_RS02035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NNW99_RS02055	COG2124	cytochrome p450
NNW99_RS02055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NNW99_RS02075	COG2706	6-phosphogluconolactonase activity
NNW99_RS02085	COG1309	transcriptional regulator
NNW99_RS02095	COG1357	PFAM Pentapeptide repeats (8 copies)
NNW99_RS02100	COG1595	DNA-templated transcription, initiation
NNW99_RS02115	COG1609	Transcriptional regulator
NNW99_RS02140	COG1172	Belongs to the binding-protein-dependent transport system permease family
NNW99_RS02145	COG1129	ABC transporter
NNW99_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS02155	COG3347	Dehydrogenase
NNW99_RS02160	COG1070	Carbohydrate kinase
NNW99_RS02165	COG0247	lactate metabolic process
NNW99_RS02170	COG1139	Iron-sulfur cluster binding protein
NNW99_RS02175	COG1556	Lactate utilization protein
NNW99_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS02185	COG1136	(ABC) transporter
NNW99_RS02200	COG0542	response to heat
NNW99_RS02230	COG0803	Belongs to the bacterial solute-binding protein 9 family
NNW99_RS02235	COG1116	anion transmembrane transporter activity
NNW99_RS02260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NNW99_RS02275	COG0019	diaminopimelate decarboxylase activity
NNW99_RS02320	COG0456	acetyltransferase
NNW99_RS02335	COG0515	serine threonine protein kinase
NNW99_RS02335	COG2815	serine threonine protein kinase
NNW99_RS02340	COG0310	cobalt ion transport
NNW99_RS02345	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NNW99_RS02355	COG1122	ATPase activity
NNW99_RS02360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NNW99_RS02385	COG0596	Alpha beta hydrolase
NNW99_RS02410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NNW99_RS02415	COG1132	(ABC) transporter
NNW99_RS02440	COG0477	Major facilitator Superfamily
NNW99_RS02445	COG0477	Major facilitator Superfamily
NNW99_RS02475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NNW99_RS02480	COG0436	Aminotransferase
NNW99_RS02485	COG4221	oxidoreductase activity
NNW99_RS02495	COG1984	allophanate hydrolase subunit 2
NNW99_RS02500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NNW99_RS02505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NNW99_RS02525	COG2271	Major facilitator Superfamily
NNW99_RS02540	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NNW99_RS02550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NNW99_RS02580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NNW99_RS02585	COG1819	glycosyl
NNW99_RS02590	COG0477	Major facilitator Superfamily
NNW99_RS02600	COG1595	DNA-templated transcription, initiation
NNW99_RS02620	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS02635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NNW99_RS02680	COG1335	isochorismatase
NNW99_RS02685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NNW99_RS02705	COG1733	regulation of RNA biosynthetic process
NNW99_RS02725	COG0789	Transcriptional regulator
NNW99_RS02730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS02735	COG1902	pentaerythritol trinitrate reductase activity
NNW99_RS02765	COG0242	peptide deformylase activity
NNW99_RS02770	COG0488	(ABC) transporter
NNW99_RS02780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NNW99_RS02790	COG1609	Transcriptional regulator
NNW99_RS02810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NNW99_RS02815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NNW99_RS02820	COG2080	2 iron, 2 sulfur cluster binding
NNW99_RS02830	COG0583	DNA-binding transcription factor activity
NNW99_RS02855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNW99_RS02875	COG4977	sequence-specific DNA binding
NNW99_RS02895	COG1881	PFAM PEBP family protein
NNW99_RS02915	COG4991	sh3 domain protein
NNW99_RS02940	COG2815	serine threonine protein kinase
NNW99_RS02940	COG0515	serine threonine protein kinase
NNW99_RS02960	COG0739	heme binding
NNW99_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS02980	COG0477	Major facilitator Superfamily
NNW99_RS02995	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS03005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NNW99_RS03015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NNW99_RS03020	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS03035	COG0477	Major facilitator Superfamily
NNW99_RS03045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NNW99_RS03065	COG0446	pyridine nucleotide-disulphide oxidoreductase
NNW99_RS03065	COG1902	pentaerythritol trinitrate reductase activity
NNW99_RS03070	COG1846	Transcriptional regulator
NNW99_RS03090	COG2268	Band 7 protein
NNW99_RS03110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NNW99_RS03115	COG0121	glutamine amidotransferase
NNW99_RS03120	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NNW99_RS03125	COG3360	Dodecin
NNW99_RS03145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NNW99_RS03160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS03170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NNW99_RS03185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NNW99_RS03190	COG1053	succinate dehydrogenase
NNW99_RS03200	COG0583	DNA-binding transcription factor activity
NNW99_RS03250	COG0726	polysaccharide deacetylase
NNW99_RS03255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NNW99_RS03255	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NNW99_RS03290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NNW99_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS03330	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS03340	COG1129	ABC transporter
NNW99_RS03345	COG1879	ABC-type sugar transport system periplasmic component
NNW99_RS03350	COG2186	Transcriptional regulator
NNW99_RS03355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS03375	COG0395	ABC-type sugar transport system, permease component
NNW99_RS03380	COG1175	transmembrane transport
NNW99_RS03390	COG1609	Transcriptional regulator
NNW99_RS03445	COG3250	beta-galactosidase activity
NNW99_RS03450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NNW99_RS03455	COG0297	glycogen (starch) synthase activity
NNW99_RS03475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NNW99_RS03485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NNW99_RS03490	COG1535	isochorismatase
NNW99_RS03490	COG3433	isochorismatase activity
NNW99_RS03495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NNW99_RS03520	COG1132	(ABC) transporter
NNW99_RS03530	COG1132	(ABC) transporter
NNW99_RS03535	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NNW99_RS03540	COG1120	ATPase activity
NNW99_RS03545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS03550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS03555	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NNW99_RS03585	COG1132	(ABC) transporter
NNW99_RS03595	COG1024	Enoyl-CoA hydratase
NNW99_RS03600	COG0668	transmembrane transport
NNW99_RS03610	COG2838	Isocitrate dehydrogenase
NNW99_RS03625	COG2124	cytochrome p450
NNW99_RS03650	COG2197	response regulator
NNW99_RS03710	COG0531	amino acid
NNW99_RS03730	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS03735	COG1132	(ABC) transporter
NNW99_RS03740	COG1132	(ABC) transporter
NNW99_RS03750	COG1120	ATPase activity
NNW99_RS03755	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS03760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS03765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NNW99_RS03815	COG2814	Major facilitator Superfamily
NNW99_RS03830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NNW99_RS03835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NNW99_RS03850	COG1609	Transcriptional regulator
NNW99_RS03855	COG0673	inositol 2-dehydrogenase activity
NNW99_RS03860	COG3548	integral membrane protein
NNW99_RS03865	COG1609	Transcriptional regulator
NNW99_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS03880	COG0673	inositol 2-dehydrogenase activity
NNW99_RS03895	COG0673	inositol 2-dehydrogenase activity
NNW99_RS03920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NNW99_RS03930	COG3718	enzyme involved in inositol metabolism
NNW99_RS03935	COG3962	Belongs to the TPP enzyme family
NNW99_RS03945	COG2188	Transcriptional regulator
NNW99_RS03980	COG0647	UMP catabolic process
NNW99_RS03990	COG0183	Belongs to the thiolase family
NNW99_RS04015	COG0402	S-adenosylhomocysteine deaminase activity
NNW99_RS04020	COG0022	dehydrogenase e1 component
NNW99_RS04025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NNW99_RS04030	COG0006	proline dipeptidase activity
NNW99_RS04055	COG0174	glutamine synthetase
NNW99_RS04095	COG0583	DNA-binding transcription factor activity
NNW99_RS04100	COG0156	8-amino-7-oxononanoate synthase activity
NNW99_RS04105	COG1063	alcohol dehydrogenase
NNW99_RS04150	COG2755	lipolytic protein G-D-S-L family
NNW99_RS04170	COG2365	Tyrosine phosphatase family
NNW99_RS04190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NNW99_RS04195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NNW99_RS04210	COG1657	PFAM Prenyltransferase squalene oxidase
NNW99_RS04220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NNW99_RS04230	COG1562	ergosterol biosynthetic process
NNW99_RS04235	COG1134	teichoic acid transport
NNW99_RS04280	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NNW99_RS04290	COG1024	Enoyl-CoA hydratase
NNW99_RS04315	COG2183	response to ionizing radiation
NNW99_RS04325	COG0488	(ABC) transporter
NNW99_RS04340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NNW99_RS04350	COG2936	dipeptidyl-peptidase activity
NNW99_RS04360	COG0010	Belongs to the arginase family
NNW99_RS04370	COG1113	amino acid transport
NNW99_RS04380	COG1024	Enoyl-CoA hydratase
NNW99_RS04380	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNW99_RS04385	COG0183	Belongs to the thiolase family
NNW99_RS04390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNW99_RS04400	COG3268	Saccharopine dehydrogenase
NNW99_RS04410	COG1515	deoxyribonuclease V activity
NNW99_RS04435	COG0488	(ABC) transporter
NNW99_RS04440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NNW99_RS04445	COG1834	amidinotransferase
NNW99_RS04495	COG1793	dna ligase
NNW99_RS04510	COG1846	Transcriptional regulator
NNW99_RS04525	COG0183	Belongs to the thiolase family
NNW99_RS04530	COG3485	protocatechuate 3,4-dioxygenase
NNW99_RS04535	COG3485	protocatechuate 3,4-dioxygenase
NNW99_RS04540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NNW99_RS04545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS04560	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NNW99_RS04585	COG3511	phospholipase C
NNW99_RS04590	COG0477	Major facilitator Superfamily
NNW99_RS04595	COG4552	Acetyltransferase involved in intracellular survival and related
NNW99_RS04620	COG3938	Belongs to the proline racemase family
NNW99_RS04625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNW99_RS04640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNW99_RS04670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NNW99_RS04695	COG1486	melibiose metabolic process
NNW99_RS04700	COG1349	DNA-binding transcription factor activity
NNW99_RS04705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NNW99_RS04725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NNW99_RS04735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NNW99_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS04775	COG0477	Major facilitator Superfamily
NNW99_RS04815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NNW99_RS04830	COG0166	Belongs to the GPI family
NNW99_RS04835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NNW99_RS04840	COG0406	alpha-ribazole phosphatase activity
NNW99_RS04855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NNW99_RS04865	COG0477	Major facilitator Superfamily
NNW99_RS04870	COG0346	lactoylglutathione lyase activity
NNW99_RS04875	COG0346	lactoylglutathione lyase activity
NNW99_RS04895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NNW99_RS04915	COG0297	glycogen (starch) synthase activity
NNW99_RS04935	COG1733	regulation of RNA biosynthetic process
NNW99_RS04940	COG0251	oxidation-reduction process
NNW99_RS04960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NNW99_RS04970	COG0702	epimerase
NNW99_RS04985	COG1454	alcohol dehydrogenase
NNW99_RS04990	COG3485	protocatechuate 3,4-dioxygenase
NNW99_RS05000	COG3284	Transcriptional regulator
NNW99_RS05015	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS05025	COG0045	succinate-CoA ligase (ADP-forming) activity
NNW99_RS05035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNW99_RS05045	COG2223	nitrite transmembrane transporter activity
NNW99_RS05080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NNW99_RS05100	COG0673	inositol 2-dehydrogenase activity
NNW99_RS05110	COG1172	Belongs to the binding-protein-dependent transport system permease family
NNW99_RS05115	COG1129	ABC transporter
NNW99_RS05120	COG1940	carbohydrate kinase activity
NNW99_RS05125	COG2050	protein possibly involved in aromatic compounds catabolism
NNW99_RS05135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NNW99_RS05150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NNW99_RS05155	COG3383	formate dehydrogenase (NAD+) activity
NNW99_RS05170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NNW99_RS05180	COG1063	alcohol dehydrogenase
NNW99_RS05210	COG0656	L-ascorbic acid biosynthetic process
NNW99_RS05220	COG5297	Belongs to the glycosyl hydrolase family 6
NNW99_RS05225	COG5297	Belongs to the glycosyl hydrolase family 6
NNW99_RS05225	COG4733	cellulase activity
NNW99_RS05240	COG3401	FG-GAP repeat protein
NNW99_RS05245	COG2378	regulation of single-species biofilm formation
NNW99_RS05260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NNW99_RS05260	COG4106	trans-aconitate 2-methyltransferase activity
NNW99_RS05265	COG2154	pterin-4-alpha-carbinolamine dehydratase
NNW99_RS05290	COG0443	Heat shock 70 kDa protein
NNW99_RS05325	COG0586	Pfam SNARE associated Golgi protein
NNW99_RS05370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NNW99_RS05370	COG0517	IMP dehydrogenase activity
NNW99_RS05375	COG0693	protein deglycase activity
NNW99_RS05395	COG1597	lipid kinase activity
NNW99_RS05470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS05495	COG1619	proteins homologs of microcin C7 resistance protein MccF
NNW99_RS05505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NNW99_RS05510	COG2362	D-Aminopeptidase
NNW99_RS05515	COG2755	lipolytic protein G-D-S-L family
NNW99_RS05540	COG2226	methyltransferase
NNW99_RS05545	COG2172	sigma factor antagonist activity
NNW99_RS05545	COG2208	phosphoserine phosphatase activity
NNW99_RS05545	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS05550	COG0477	Major facilitator Superfamily
NNW99_RS05565	COG0596	Alpha beta hydrolase
NNW99_RS05580	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNW99_RS05590	COG0604	alcohol dehydrogenase
NNW99_RS05595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS05595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS05610	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS05615	COG0688	phosphatidylethanolamine metabolic process
NNW99_RS05625	COG1929	Belongs to the glycerate kinase type-1 family
NNW99_RS05645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NNW99_RS05660	COG0640	Transcriptional regulator
NNW99_RS05680	COG0488	(ABC) transporter
NNW99_RS05695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NNW99_RS05720	COG0121	glutamine amidotransferase
NNW99_RS05725	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NNW99_RS05735	COG0483	inositol monophosphate 1-phosphatase activity
NNW99_RS05750	COG1953	Uracil, thiamine, allantoin
NNW99_RS05760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NNW99_RS05775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNW99_RS05800	COG0542	response to heat
NNW99_RS05805	COG0405	Gamma-glutamyltransferase
NNW99_RS05815	COG1073	alpha beta
NNW99_RS05820	COG1126	abc transporter atp-binding protein
NNW99_RS05840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NNW99_RS05845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS05870	COG0252	asparaginase activity
NNW99_RS05895	COG0367	asparagine synthase
NNW99_RS05940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NNW99_RS05950	COG1940	carbohydrate kinase activity
NNW99_RS05955	COG2188	Transcriptional regulator
NNW99_RS05960	COG0673	inositol 2-dehydrogenase activity
NNW99_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS06000	COG4266	Belongs to the allantoicase family
NNW99_RS06005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NNW99_RS06010	COG1414	Transcriptional regulator
NNW99_RS06025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NNW99_RS06045	COG1120	ATPase activity
NNW99_RS06085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NNW99_RS06090	COG1181	Belongs to the D-alanine--D-alanine ligase family
NNW99_RS06100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NNW99_RS06105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NNW99_RS06110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS06115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NNW99_RS06140	COG1733	regulation of RNA biosynthetic process
NNW99_RS06145	COG0436	Aminotransferase
NNW99_RS06185	COG2233	PERMEase
NNW99_RS06200	COG2351	hydroxyisourate hydrolase activity
NNW99_RS06220	COG0668	transmembrane transport
NNW99_RS06225	COG3622	Belongs to the hyi family
NNW99_RS06230	COG2084	Dehydrogenase
NNW99_RS06235	COG0753	catalase activity
NNW99_RS06250	COG3960	tartronate-semialdehyde synthase activity
NNW99_RS06265	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS06270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NNW99_RS06300	COG0628	permease
NNW99_RS06320	COG0137	argininosuccinate synthase activity
NNW99_RS06335	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NNW99_RS06340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NNW99_RS06360	COG1522	sequence-specific DNA binding
NNW99_RS06375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NNW99_RS06385	COG0726	polysaccharide deacetylase
NNW99_RS06395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NNW99_RS06395	COG3608	succinylglutamate desuccinylase aspartoacylase
NNW99_RS06400	COG2252	PERMEase
NNW99_RS06405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NNW99_RS06430	COG1802	Transcriptional regulator
NNW99_RS06460	COG0028	Belongs to the TPP enzyme family
NNW99_RS06475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NNW99_RS06495	COG3629	intracellular signal transduction
NNW99_RS06495	COG3903	Transcriptional regulator
NNW99_RS06500	COG1162	GTPase activity
NNW99_RS06520	COG0277	FAD linked oxidase domain protein
NNW99_RS06540	COG0395	ABC-type sugar transport system, permease component
NNW99_RS06555	COG1131	(ABC) transporter
NNW99_RS06660	COG0531	amino acid
NNW99_RS06665	COG2040	homocysteine
NNW99_RS06670	COG1609	Transcriptional regulator
NNW99_RS06730	COG0395	ABC-type sugar transport system, permease component
NNW99_RS06735	COG1175	transmembrane transport
NNW99_RS06755	COG1609	Transcriptional regulator
NNW99_RS06765	COG1175	transmembrane transport
NNW99_RS06780	COG0673	inositol 2-dehydrogenase activity
NNW99_RS06785	COG1609	Transcriptional regulator
NNW99_RS06820	COG1917	Cupin 2, conserved barrel domain protein
NNW99_RS06820	COG4977	sequence-specific DNA binding
NNW99_RS06835	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS06855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NNW99_RS06865	COG0175	sulfate reduction
NNW99_RS06870	COG0529	Catalyzes the synthesis of activated sulfate
NNW99_RS06890	COG1116	anion transmembrane transporter activity
NNW99_RS06895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NNW99_RS06955	COG2409	Drug exporters of the RND superfamily
NNW99_RS06970	COG2205	protein histidine kinase activity
NNW99_RS06975	COG0745	RESPONSE REGULATOR receiver
NNW99_RS07065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NNW99_RS07085	COG1309	transcriptional regulator
NNW99_RS07090	COG1404	Belongs to the peptidase S8 family
NNW99_RS07120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NNW99_RS07130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NNW99_RS07135	COG0640	Transcriptional regulator
NNW99_RS07175	COG1174	glycine betaine transport
NNW99_RS07180	COG1174	glycine betaine transport
NNW99_RS07190	COG2205	protein histidine kinase activity
NNW99_RS07195	COG0745	RESPONSE REGULATOR receiver
NNW99_RS07230	COG0395	ABC-type sugar transport system, permease component
NNW99_RS07235	COG1175	transmembrane transport
NNW99_RS07265	COG4821	SIS domain
NNW99_RS07270	COG1737	Transcriptional regulator
NNW99_RS07290	COG1175	transmembrane transport
NNW99_RS07295	COG0395	ABC-type sugar transport system, permease component
NNW99_RS07315	COG1472	Belongs to the glycosyl hydrolase 3 family
NNW99_RS07325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NNW99_RS07330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NNW99_RS07355	COG0288	reversible hydration of carbon dioxide
NNW99_RS07365	COG0330	HflC and HflK could
NNW99_RS07375	COG2326	polyphosphate kinase activity
NNW99_RS07390	COG0723	plastoquinol--plastocyanin reductase activity
NNW99_RS07390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNW99_RS07410	COG1116	anion transmembrane transporter activity
NNW99_RS07440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NNW99_RS07445	COG3220	belongs to the UPF0276 family
NNW99_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS07480	COG3253	May function as heme-dependent peroxidase
NNW99_RS07485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NNW99_RS07500	COG0446	pyridine nucleotide-disulphide oxidoreductase
NNW99_RS07515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NNW99_RS07525	COG0673	inositol 2-dehydrogenase activity
NNW99_RS07535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NNW99_RS07550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NNW99_RS07555	COG3833	ABC-type maltose transport systems, permease component
NNW99_RS07560	COG1175	transmembrane transport
NNW99_RS07570	COG3250	beta-galactosidase activity
NNW99_RS07575	COG1609	Transcriptional regulator
NNW99_RS07580	COG0183	Belongs to the thiolase family
NNW99_RS07585	COG1024	Enoyl-CoA hydratase
NNW99_RS07585	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNW99_RS07610	COG0531	amino acid
NNW99_RS07615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NNW99_RS07620	COG4214	carbohydrate transport
NNW99_RS07630	COG4213	ABC transporter substrate-binding protein
NNW99_RS07635	COG1940	carbohydrate kinase activity
NNW99_RS07640	COG0395	ABC-type sugar transport system, permease component
NNW99_RS07645	COG1175	transmembrane transport
NNW99_RS07650	COG1653	transport
NNW99_RS07670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NNW99_RS07675	COG0069	glutamate synthase activity
NNW99_RS07675	COG0067	glutamate synthase
NNW99_RS07675	COG0070	glutamate synthase
NNW99_RS07700	COG0395	ABC-type sugar transport system, permease component
NNW99_RS07705	COG4209	transmembrane transport
NNW99_RS07710	COG3458	cephalosporin-C deacetylase activity
NNW99_RS07715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NNW99_RS07725	COG0456	acetyltransferase
NNW99_RS07730	COG0583	DNA-binding transcription factor activity
NNW99_RS07775	COG4213	ABC transporter substrate-binding protein
NNW99_RS07785	COG4214	carbohydrate transport
NNW99_RS07795	COG2205	protein histidine kinase activity
NNW99_RS07800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NNW99_RS07815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NNW99_RS07825	COG0019	diaminopimelate decarboxylase activity
NNW99_RS07830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NNW99_RS07835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NNW99_RS07855	COG0444	Belongs to the ABC transporter superfamily
NNW99_RS07860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS07865	COG0601	transmembrane transport
NNW99_RS07905	COG1335	isochorismatase
NNW99_RS07915	COG1024	Enoyl-CoA hydratase
NNW99_RS07925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NNW99_RS07930	COG2235	arginine
NNW99_RS07955	COG0475	glutathione-regulated potassium exporter activity
NNW99_RS07965	COG2255	four-way junction helicase activity
NNW99_RS07975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NNW99_RS08010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NNW99_RS08015	COG1799	cell septum assembly
NNW99_RS08020	COG0243	molybdopterin cofactor binding
NNW99_RS08050	COG3594	Acyltransferase
NNW99_RS08055	COG4172	Belongs to the ABC transporter superfamily
NNW99_RS08060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS08065	COG0601	transmembrane transport
NNW99_RS08085	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS08090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NNW99_RS08100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NNW99_RS08135	COG1929	Belongs to the glycerate kinase type-1 family
NNW99_RS08160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NNW99_RS08160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NNW99_RS08170	COG2197	response regulator
NNW99_RS08215	COG1546	Belongs to the CinA family
NNW99_RS08215	COG1058	Belongs to the CinA family
NNW99_RS08225	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS08230	COG2197	response regulator
NNW99_RS08240	COG1136	(ABC) transporter
NNW99_RS08255	COG0659	secondary active sulfate transmembrane transporter activity
NNW99_RS08265	COG5002	protein histidine kinase activity
NNW99_RS08270	COG0745	RESPONSE REGULATOR receiver
NNW99_RS08350	COG0596	Alpha beta hydrolase
NNW99_RS08385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NNW99_RS08390	COG0531	amino acid
NNW99_RS08395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NNW99_RS08400	COG0569	domain protein
NNW99_RS08440	COG0756	dUTP diphosphatase activity
NNW99_RS08465	COG2205	protein histidine kinase activity
NNW99_RS08470	COG0745	RESPONSE REGULATOR receiver
NNW99_RS08485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NNW99_RS08520	COG1435	thymidine kinase activity
NNW99_RS08535	COG1042	CoA-binding domain protein
NNW99_RS08535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NNW99_RS08535	COG0045	succinate-CoA ligase (ADP-forming) activity
NNW99_RS08540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NNW99_RS08545	COG1802	Transcriptional regulator
NNW99_RS08560	COG0612	Peptidase, M16
NNW99_RS08565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NNW99_RS08585	COG0372	Belongs to the citrate synthase family
NNW99_RS08600	COG3290	protein histidine kinase activity
NNW99_RS08605	COG4565	transcriptional regulatory protein
NNW99_RS08610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NNW99_RS08620	COG0187	DNA topoisomerase II activity
NNW99_RS08635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NNW99_RS08640	COG1802	Transcriptional regulator
NNW99_RS08645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NNW99_RS08680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NNW99_RS08700	COG0588	phosphoglycerate mutase activity
NNW99_RS08715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NNW99_RS08720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NNW99_RS08725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NNW99_RS08760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NNW99_RS08770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NNW99_RS08775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NNW99_RS08785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NNW99_RS08805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NNW99_RS08810	COG1349	DNA-binding transcription factor activity
NNW99_RS08815	COG0800	Aldolase
NNW99_RS08820	COG2271	Major facilitator Superfamily
NNW99_RS08830	COG2197	response regulator
NNW99_RS08855	COG2358	TRAP transporter, solute receptor (TAXI family
NNW99_RS08860	COG2205	protein histidine kinase activity
NNW99_RS08865	COG0745	RESPONSE REGULATOR receiver
NNW99_RS08870	COG1126	abc transporter atp-binding protein
NNW99_RS08875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NNW99_RS08880	COG0765	amino acid transport
NNW99_RS08885	COG0765	amino acid transport
NNW99_RS08910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NNW99_RS08915	COG0628	permease
NNW99_RS08945	COG1201	RNA secondary structure unwinding
NNW99_RS08950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NNW99_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS08965	COG0783	Belongs to the Dps family
NNW99_RS08970	COG1396	sequence-specific DNA binding
NNW99_RS08985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NNW99_RS08995	COG1674	ftsk spoiiie
NNW99_RS09005	COG4999	Histidine kinase
NNW99_RS09005	COG2205	protein histidine kinase activity
NNW99_RS09005	COG3437	response regulator, receiver
NNW99_RS09005	COG3850	Histidine kinase
NNW99_RS09010	COG2770	Histidine kinase
NNW99_RS09010	COG2208	phosphoserine phosphatase activity
NNW99_RS09040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NNW99_RS09045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNW99_RS09050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NNW99_RS09070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NNW99_RS09075	COG0612	Peptidase, M16
NNW99_RS09080	COG1185	polyribonucleotide nucleotidyltransferase activity
NNW99_RS09085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NNW99_RS09095	COG0455	bacterial-type flagellum organization
NNW99_RS09105	COG0601	transmembrane transport
NNW99_RS09110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS09115	COG0444	Belongs to the ABC transporter superfamily
NNW99_RS09135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NNW99_RS09140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NNW99_RS09150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NNW99_RS09165	COG0779	Required for maturation of 30S ribosomal subunits
NNW99_RS09185	COG0442	prolyl-tRNA aminoacylation
NNW99_RS09210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NNW99_RS09215	COG0750	zinc metalloprotease
NNW99_RS09220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NNW99_RS09260	COG0395	ABC-type sugar transport system, permease component
NNW99_RS09265	COG4209	transmembrane transport
NNW99_RS09280	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS09285	COG2508	Transcriptional regulator
NNW99_RS09285	COG2508	Transcriptional regulator
NNW99_RS09305	COG2318	DinB family
NNW99_RS09320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNW99_RS09325	COG1177	transmembrane transport
NNW99_RS09335	COG3842	ATPase activity
NNW99_RS09365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NNW99_RS09395	COG0464	growth
NNW99_RS09465	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS09475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NNW99_RS09510	COG3842	ATPase activity
NNW99_RS09515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NNW99_RS09525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NNW99_RS09535	COG0575	Belongs to the CDS family
NNW99_RS09540	COG0233	cytoplasmic translational termination
NNW99_RS09545	COG0528	UMP kinase activity
NNW99_RS09550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NNW99_RS09555	COG0052	Belongs to the universal ribosomal protein uS2 family
NNW99_RS09560	COG4942	peptidase
NNW99_RS09570	COG1191	sigma factor activity
NNW99_RS09585	COG0792	nuclease activity
NNW99_RS09600	COG0681	Belongs to the peptidase S26 family
NNW99_RS09605	COG0681	Belongs to the peptidase S26 family
NNW99_RS09615	COG0681	Belongs to the peptidase S26 family
NNW99_RS09620	COG0335	large ribosomal subunit rRNA binding
NNW99_RS09625	COG0336	Belongs to the RNA methyltransferase TrmD family
NNW99_RS09630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NNW99_RS09635	COG1837	Belongs to the UPF0109 family
NNW99_RS09640	COG0228	four-way junction DNA binding
NNW99_RS09650	COG0442	prolyl-tRNA aminoacylation
NNW99_RS09655	COG4106	trans-aconitate 2-methyltransferase activity
NNW99_RS09670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NNW99_RS09710	COG0477	Major facilitator Superfamily
NNW99_RS09715	COG1196	nuclear chromosome segregation
NNW99_RS09725	COG1254	Belongs to the acylphosphatase family
NNW99_RS09730	COG2340	Cysteine-rich secretory protein family
NNW99_RS09735	COG1733	regulation of RNA biosynthetic process
NNW99_RS09740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NNW99_RS09745	COG0571	ribonuclease III activity
NNW99_RS09750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NNW99_RS09765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NNW99_RS09770	COG0742	ribosomal rna small subunit methyltransferase
NNW99_RS09780	COG0326	Molecular chaperone. Has ATPase activity
NNW99_RS09790	COG1461	Dihydroxyacetone kinase
NNW99_RS09795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NNW99_RS09800	COG0351	phosphomethylpyrimidine kinase
NNW99_RS09820	COG1181	Belongs to the D-alanine--D-alanine ligase family
NNW99_RS09825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NNW99_RS09835	COG1920	GTP binding
NNW99_RS09845	COG0776	regulation of translation
NNW99_RS09855	COG0066	3-isopropylmalate dehydratase activity
NNW99_RS09860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NNW99_RS09865	COG1414	Transcriptional regulator
NNW99_RS09905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NNW99_RS09910	COG0179	Fumarylacetoacetate (FAA) hydrolase
NNW99_RS09920	COG5002	protein histidine kinase activity
NNW99_RS09925	COG2018	Roadblock/LC7 domain
NNW99_RS09945	COG2018	Roadblock/LC7 domain
NNW99_RS09965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NNW99_RS09975	COG0300	oxidoreductase activity
NNW99_RS09980	COG2353	YceI-like domain
NNW99_RS10020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NNW99_RS10035	COG2957	Belongs to the agmatine deiminase family
NNW99_RS10040	COG0804	urea catabolic process
NNW99_RS10045	COG0832	Belongs to the urease beta subunit family
NNW99_RS10045	COG0831	urea catabolic process
NNW99_RS10055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NNW99_RS10060	COG0473	3-isopropylmalate dehydrogenase activity
NNW99_RS10080	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS10085	COG0506	proline dehydrogenase activity
NNW99_RS10090	COG3835	regulator
NNW99_RS10100	COG0747	negative chemotaxis
NNW99_RS10105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS10115	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS10125	COG0477	Major facilitator Superfamily
NNW99_RS10130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NNW99_RS10135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NNW99_RS10140	COG0440	acetolactate synthase activity
NNW99_RS10150	COG5001	Diguanylate cyclase
NNW99_RS10160	COG0667	Aldo Keto reductase
NNW99_RS10185	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NNW99_RS10185	COG1672	PFAM Archaeal ATPase
NNW99_RS10200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NNW99_RS10205	COG2409	Drug exporters of the RND superfamily
NNW99_RS10215	COG2226	methyltransferase
NNW99_RS10220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NNW99_RS10230	COG0154	amidase activity
NNW99_RS10235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NNW99_RS10245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NNW99_RS10255	COG4221	oxidoreductase activity
NNW99_RS10260	COG1611	Belongs to the LOG family
NNW99_RS10280	COG0482	sulfurtransferase activity
NNW99_RS10305	COG1309	transcriptional regulator
NNW99_RS10320	COG2860	membrane
NNW99_RS10325	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS10330	COG0444	Belongs to the ABC transporter superfamily
NNW99_RS10340	COG0747	negative chemotaxis
NNW99_RS10345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS10365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NNW99_RS10370	COG0509	glycine decarboxylation via glycine cleavage system
NNW99_RS10375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NNW99_RS10380	COG1760	l-serine dehydratase
NNW99_RS10385	COG1181	Belongs to the D-alanine--D-alanine ligase family
NNW99_RS10430	COG3757	hydrolase, family 25
NNW99_RS10430	COG3409	Peptidoglycan-binding domain 1 protein
NNW99_RS10440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NNW99_RS10445	COG1119	ATPase activity
NNW99_RS10455	COG0789	Transcriptional regulator
NNW99_RS10480	COG1376	ErfK ybiS ycfS ynhG family protein
NNW99_RS10485	COG1376	ErfK ybiS ycfS ynhG family protein
NNW99_RS10495	COG3119	arylsulfatase activity
NNW99_RS10500	COG2197	response regulator
NNW99_RS10505	COG4585	Histidine kinase
NNW99_RS10515	COG1131	(ABC) transporter
NNW99_RS10520	COG1132	(ABC) transporter
NNW99_RS10525	COG1132	(ABC) transporter
NNW99_RS10535	COG1132	(ABC) transporter
NNW99_RS10555	COG0058	SHG alpha-glucan phosphorylase activity
NNW99_RS10565	COG0366	Alpha amylase catalytic
NNW99_RS10570	COG0366	Alpha amylase catalytic
NNW99_RS10575	COG3281	Trehalose synthase
NNW99_RS10580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NNW99_RS10595	COG3118	belongs to the thioredoxin family
NNW99_RS10595	COG0492	ferredoxin-NADP+ reductase activity
NNW99_RS10605	COG1522	sequence-specific DNA binding
NNW99_RS10615	COG0667	Aldo Keto reductase
NNW99_RS10620	COG2409	Drug exporters of the RND superfamily
NNW99_RS10635	COG2124	cytochrome p450
NNW99_RS10650	COG3290	protein histidine kinase activity
NNW99_RS10655	COG4565	transcriptional regulatory protein
NNW99_RS10665	COG1175	transmembrane transport
NNW99_RS10670	COG0395	ABC-type sugar transport system, permease component
NNW99_RS10675	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS10680	COG2610	gluconate transmembrane transporter activity
NNW99_RS10685	COG1414	Transcriptional regulator
NNW99_RS10700	COG0205	6-phosphofructokinase activity
NNW99_RS10705	COG0280	phosphate acetyltransferase
NNW99_RS10705	COG0857	belongs to the CobB CobQ family
NNW99_RS10710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NNW99_RS10755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS10755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS10820	COG0745	RESPONSE REGULATOR receiver
NNW99_RS10835	COG0183	Belongs to the thiolase family
NNW99_RS10840	COG0346	lactoylglutathione lyase activity
NNW99_RS10855	COG1131	(ABC) transporter
NNW99_RS10890	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NNW99_RS10905	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNW99_RS10940	COG4585	Histidine kinase
NNW99_RS10945	COG2197	response regulator
NNW99_RS10960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NNW99_RS10965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NNW99_RS10970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NNW99_RS10975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NNW99_RS10980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NNW99_RS10985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NNW99_RS10990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NNW99_RS11010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NNW99_RS11015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NNW99_RS11025	COG2890	protein-(glutamine-N5) methyltransferase activity
NNW99_RS11030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NNW99_RS11035	COG0254	rRNA binding
NNW99_RS11055	COG0083	homoserine kinase activity
NNW99_RS11060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NNW99_RS11065	COG0460	homoserine dehydrogenase
NNW99_RS11070	COG0019	diaminopimelate decarboxylase activity
NNW99_RS11075	COG0018	arginyl-trna synthetase
NNW99_RS11095	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NNW99_RS11100	COG1793	dna ligase
NNW99_RS11100	COG3285	dna ligase
NNW99_RS11120	COG2205	protein histidine kinase activity
NNW99_RS11175	COG3883	PFAM NLP P60 protein
NNW99_RS11175	COG0791	NLP P60 protein
NNW99_RS11200	COG5002	protein histidine kinase activity
NNW99_RS11215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NNW99_RS11230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NNW99_RS11235	COG0745	RESPONSE REGULATOR receiver
NNW99_RS11240	COG2205	protein histidine kinase activity
NNW99_RS11245	COG0508	dehydrogenase complex catalyzes the overall conversion of
NNW99_RS11245	COG0567	Dehydrogenase, E1 component
NNW99_RS11270	COG0542	response to heat
NNW99_RS11280	COG0604	alcohol dehydrogenase
NNW99_RS11285	COG0281	malic enzyme
NNW99_RS11290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NNW99_RS11300	COG1126	abc transporter atp-binding protein
NNW99_RS11305	COG4106	trans-aconitate 2-methyltransferase activity
NNW99_RS11345	COG4941	Belongs to the sigma-70 factor family
NNW99_RS11365	COG0456	acetyltransferase
NNW99_RS11370	COG0142	geranyltranstransferase activity
NNW99_RS11375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NNW99_RS11385	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NNW99_RS11415	COG1597	lipid kinase activity
NNW99_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS11440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NNW99_RS11445	COG0363	glucosamine-6-phosphate deaminase activity
NNW99_RS11455	COG1476	TRANSCRIPTIONal
NNW99_RS11460	COG1472	Belongs to the glycosyl hydrolase 3 family
NNW99_RS11465	COG0395	ABC-type sugar transport system, permease component
NNW99_RS11470	COG1175	transmembrane transport
NNW99_RS11475	COG2182	Extracellular solute-binding protein
NNW99_RS11480	COG2188	Transcriptional regulator
NNW99_RS11505	COG4977	sequence-specific DNA binding
NNW99_RS11510	COG2124	cytochrome p450
NNW99_RS11520	COG0242	peptide deformylase activity
NNW99_RS11535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NNW99_RS11535	COG2199	diguanylate cyclase activity
NNW99_RS11540	COG5662	AntiSigma factor
NNW99_RS11545	COG1595	DNA-templated transcription, initiation
NNW99_RS11555	COG2135	peptidase activity
NNW99_RS11565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NNW99_RS11570	COG1162	GTPase activity
NNW99_RS11575	COG2076	Multidrug Resistance protein
NNW99_RS11585	COG0483	inositol monophosphate 1-phosphatase activity
NNW99_RS11630	COG1615	UPF0182 protein
NNW99_RS11640	COG3480	Lon protease (S16) C-terminal proteolytic domain
NNW99_RS11690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NNW99_RS11725	COG2816	NAD+ diphosphatase activity
NNW99_RS11730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NNW99_RS11735	COG0210	DNA helicase
NNW99_RS11760	COG0596	Alpha beta hydrolase
NNW99_RS11795	COG0601	transmembrane transport
NNW99_RS11800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS11805	COG0747	negative chemotaxis
NNW99_RS11845	COG0513	Belongs to the DEAD box helicase family
NNW99_RS11855	COG1432	Conserved Protein
NNW99_RS11865	COG1864	DNA RNA non-specific endonuclease
NNW99_RS11865	COG3591	Belongs to the peptidase S1B family
NNW99_RS11870	COG2095	MarC family integral membrane protein
NNW99_RS11875	COG0613	PHP domain protein
NNW99_RS11885	COG2814	Major facilitator Superfamily
NNW99_RS11895	COG0598	Magnesium transport protein CorA
NNW99_RS11930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NNW99_RS11935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NNW99_RS11945	COG1595	DNA-templated transcription, initiation
NNW99_RS11960	COG1024	Enoyl-CoA hydratase
NNW99_RS11965	COG0519	Catalyzes the synthesis of GMP from XMP
NNW99_RS11975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NNW99_RS11985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NNW99_RS12020	COG2197	response regulator
NNW99_RS12025	COG4585	Histidine kinase
NNW99_RS12035	COG1131	(ABC) transporter
NNW99_RS12050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NNW99_RS12070	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS12080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS12085	COG0601	transmembrane transport
NNW99_RS12095	COG1217	gtp-binding protein TYPA
NNW99_RS12120	COG1053	succinate dehydrogenase
NNW99_RS12170	COG4585	Histidine kinase
NNW99_RS12175	COG2197	response regulator
NNW99_RS12200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS12220	COG0012	GTP binding
NNW99_RS12230	COG1940	carbohydrate kinase activity
NNW99_RS12235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NNW99_RS12240	COG1570	exodeoxyribonuclease VII activity
NNW99_RS12245	COG1722	exodeoxyribonuclease VII activity
NNW99_RS12250	COG0778	Nitroreductase
NNW99_RS12275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NNW99_RS12275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NNW99_RS12280	COG0114	fumarate hydratase activity
NNW99_RS12295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NNW99_RS12315	COG1136	(ABC) transporter
NNW99_RS12330	COG0450	alkyl hydroperoxide reductase
NNW99_RS12335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS12350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NNW99_RS12355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NNW99_RS12365	COG2226	methyltransferase
NNW99_RS12370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NNW99_RS12445	COG3920	Histidine kinase
NNW99_RS12475	COG2894	cell division
NNW99_RS12535	COG2610	gluconate transmembrane transporter activity
NNW99_RS12545	COG1414	Transcriptional regulator
NNW99_RS12560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NNW99_RS12570	COG0436	Aminotransferase
NNW99_RS12585	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NNW99_RS12595	COG1309	transcriptional regulator
NNW99_RS12605	COG1331	Highly conserved protein containing a thioredoxin domain
NNW99_RS12630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NNW99_RS12640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NNW99_RS12655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NNW99_RS12660	COG2255	four-way junction helicase activity
NNW99_RS12665	COG1595	DNA-templated transcription, initiation
NNW99_RS12685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NNW99_RS12705	COG1090	epimerase
NNW99_RS12720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS12725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS12730	COG1064	alcohol dehydrogenase
NNW99_RS12740	COG1404	Belongs to the peptidase S8 family
NNW99_RS12745	COG1136	(ABC) transporter
NNW99_RS12770	COG2986	histidine ammonia-lyase
NNW99_RS12780	COG1024	Enoyl-CoA hydratase
NNW99_RS12790	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NNW99_RS12800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NNW99_RS12815	COG0424	maF-like protein
NNW99_RS12825	COG4770	biotin carboxylase activity
NNW99_RS12850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NNW99_RS12860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NNW99_RS12865	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS12870	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS12885	COG1595	DNA-templated transcription, initiation
NNW99_RS12890	COG0745	RESPONSE REGULATOR receiver
NNW99_RS12895	COG2205	protein histidine kinase activity
NNW99_RS12920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NNW99_RS12930	COG0583	DNA-binding transcription factor activity
NNW99_RS12935	COG2814	Major facilitator Superfamily
NNW99_RS12940	COG0592	DNA-directed DNA polymerase activity
NNW99_RS12975	COG1079	Belongs to the binding-protein-dependent transport system permease family
NNW99_RS12985	COG3845	ABC transporter
NNW99_RS12990	COG1744	ABC transporter substrate-binding protein PnrA-like
NNW99_RS12995	COG1744	ABC transporter substrate-binding protein PnrA-like
NNW99_RS13000	COG1473	amidohydrolase
NNW99_RS13000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NNW99_RS13005	COG2226	methyltransferase
NNW99_RS13015	COG2089	acid synthase
NNW99_RS13030	COG1216	Glycosyl transferase, family 2
NNW99_RS13040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NNW99_RS13065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS13065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS13085	COG4221	oxidoreductase activity
NNW99_RS13095	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NNW99_RS13100	COG0697	spore germination
NNW99_RS13105	COG0583	DNA-binding transcription factor activity
NNW99_RS13135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NNW99_RS13160	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS13250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NNW99_RS13260	COG2009	succinate dehydrogenase
NNW99_RS13270	COG1053	succinate dehydrogenase
NNW99_RS13310	COG0747	negative chemotaxis
NNW99_RS13320	COG1408	metallophosphoesterase
NNW99_RS13330	COG1686	Belongs to the peptidase S11 family
NNW99_RS13335	COG1295	ribonuclease BN
NNW99_RS13350	COG0671	phosphoesterase, PA-phosphatase related
NNW99_RS13370	COG0180	Tryptophanyl-tRNA synthetase
NNW99_RS13375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NNW99_RS13380	COG0754	glutathionylspermidine amidase activity
NNW99_RS13400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NNW99_RS13400	COG0512	Glutamine amidotransferase of anthranilate synthase
NNW99_RS13405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NNW99_RS13415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNW99_RS13425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS13430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NNW99_RS13435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS13440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS13455	COG4176	ABC-type proline glycine betaine transport system permease component
NNW99_RS13460	COG4175	Glycine betaine
NNW99_RS13460	COG0517	IMP dehydrogenase activity
NNW99_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS13475	COG2318	DinB family
NNW99_RS13480	COG0039	L-malate dehydrogenase activity
NNW99_RS13495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NNW99_RS13510	COG2815	serine threonine protein kinase
NNW99_RS13510	COG0515	serine threonine protein kinase
NNW99_RS13525	COG1063	alcohol dehydrogenase
NNW99_RS13535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NNW99_RS13595	COG0138	bifunctional purine biosynthesis protein purh
NNW99_RS13625	COG0045	succinate-CoA ligase (ADP-forming) activity
NNW99_RS13635	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NNW99_RS13650	COG0714	Associated with various cellular activities
NNW99_RS13665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS13665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NNW99_RS13670	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NNW99_RS13675	COG0739	heme binding
NNW99_RS13705	COG2197	response regulator
NNW99_RS13750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NNW99_RS13750	COG0519	Catalyzes the synthesis of GMP from XMP
NNW99_RS13775	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS13780	COG0515	serine threonine protein kinase
NNW99_RS13785	COG0515	serine threonine protein kinase
NNW99_RS13795	COG0515	serine threonine protein kinase
NNW99_RS13800	COG2815	serine threonine protein kinase
NNW99_RS13800	COG0515	serine threonine protein kinase
NNW99_RS13815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NNW99_RS13825	COG0516	GMP reductase activity
NNW99_RS13835	COG1595	DNA-templated transcription, initiation
NNW99_RS13850	COG0583	DNA-binding transcription factor activity
NNW99_RS13860	COG4221	oxidoreductase activity
NNW99_RS13905	COG0459	protein refolding
NNW99_RS13910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NNW99_RS13915	COG0726	polysaccharide deacetylase
NNW99_RS13920	COG0726	polysaccharide deacetylase
NNW99_RS13930	COG4941	Belongs to the sigma-70 factor family
NNW99_RS13940	COG1316	TRANSCRIPTIONal
NNW99_RS13945	COG1609	Transcriptional regulator
NNW99_RS13960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NNW99_RS13970	COG0456	acetyltransferase
NNW99_RS13970	COG1214	PFAM Peptidase M22, glycoprotease
NNW99_RS13985	COG0802	atpase or kinase
NNW99_RS13995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NNW99_RS14010	COG0736	holo-[acyl-carrier-protein] synthase activity
NNW99_RS14025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NNW99_RS14040	COG1072	(Pantothenic acid kinase))
NNW99_RS14050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NNW99_RS14055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NNW99_RS14060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NNW99_RS14095	COG2843	Capsule synthesis protein
NNW99_RS14105	COG0101	tRNA pseudouridine synthase activity
NNW99_RS14110	COG0203	ribosomal protein L17
NNW99_RS14115	COG0202	RNA polymerase activity
NNW99_RS14120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NNW99_RS14125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NNW99_RS14130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NNW99_RS14135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NNW99_RS14155	COG0563	adenylate kinase activity
NNW99_RS14160	COG0201	protein transport
NNW99_RS14165	COG0200	Binds to the 23S rRNA
NNW99_RS14170	COG1841	ribosomal large subunit assembly
NNW99_RS14175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NNW99_RS14180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NNW99_RS14185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NNW99_RS14190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NNW99_RS14195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NNW99_RS14200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NNW99_RS14205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NNW99_RS14210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NNW99_RS14215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NNW99_RS14220	COG0255	Belongs to the universal ribosomal protein uL29 family
NNW99_RS14225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NNW99_RS14230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NNW99_RS14235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NNW99_RS14240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NNW99_RS14245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NNW99_RS14250	COG0089	rRNA binding
NNW99_RS14255	COG0088	Forms part of the polypeptide exit tunnel
NNW99_RS14260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NNW99_RS14265	COG0051	transcription antitermination factor activity, RNA binding
NNW99_RS14280	COG3210	domain, Protein
NNW99_RS14300	COG0793	Belongs to the peptidase S41A family
NNW99_RS14330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NNW99_RS14335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NNW99_RS14340	COG0049	tRNA binding
NNW99_RS14345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NNW99_RS14380	COG0501	Belongs to the peptidase M48B family
NNW99_RS14385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NNW99_RS14390	COG0085	RNA polymerase activity
NNW99_RS14395	COG0222	ribosome binding
NNW99_RS14400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NNW99_RS14415	COG0081	regulation of translation
NNW99_RS14420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NNW99_RS14425	COG0250	Participates in transcription elongation, termination and antitermination
NNW99_RS14430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NNW99_RS14440	COG0436	Aminotransferase
NNW99_RS14445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NNW99_RS14450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NNW99_RS14460	COG0477	Major facilitator Superfamily
NNW99_RS14475	COG2030	dehydratase
NNW99_RS14480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NNW99_RS14500	COG0702	epimerase
NNW99_RS14515	COG1666	GTP binding
NNW99_RS14520	COG2261	transglycosylase associated protein
NNW99_RS14530	COG3304	Inner membrane component domain
NNW99_RS14535	COG0501	Belongs to the peptidase M48B family
NNW99_RS14540	COG1007	ATP synthesis coupled electron transport
NNW99_RS14550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NNW99_RS14555	COG0713	ATP synthesis coupled electron transport
NNW99_RS14560	COG0839	Belongs to the complex I subunit 6 family
NNW99_RS14565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NNW99_RS14570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NNW99_RS14575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NNW99_RS14580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NNW99_RS14585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NNW99_RS14605	COG0674	pyruvate-flavodoxin oxidoreductase activity
NNW99_RS14605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NNW99_RS14610	COG1013	pyruvate-flavodoxin oxidoreductase activity
NNW99_RS14615	COG1733	regulation of RNA biosynthetic process
NNW99_RS14620	COG0702	epimerase
NNW99_RS14635	COG1733	regulation of RNA biosynthetic process
NNW99_RS14645	COG4935	Belongs to the peptidase S8 family
NNW99_RS14645	COG2234	aminopeptidase activity
NNW99_RS14675	COG1131	(ABC) transporter
NNW99_RS14685	COG0142	geranyltranstransferase activity
NNW99_RS14695	COG0561	phosphatase activity
NNW99_RS14750	COG2188	Transcriptional regulator
NNW99_RS14765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NNW99_RS14775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NNW99_RS14785	COG1007	ATP synthesis coupled electron transport
NNW99_RS14795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NNW99_RS14800	COG0713	ATP synthesis coupled electron transport
NNW99_RS14805	COG0839	Belongs to the complex I subunit 6 family
NNW99_RS14810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NNW99_RS14815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NNW99_RS14820	COG1034	ATP synthesis coupled electron transport
NNW99_RS14825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NNW99_RS14835	COG0649	NAD binding
NNW99_RS14840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NNW99_RS14845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NNW99_RS14855	COG0791	NLP P60 protein
NNW99_RS14855	COG1388	LysM domain
NNW99_RS14855	COG3103	Sh3 type 3 domain protein
NNW99_RS14880	COG2226	methyltransferase
NNW99_RS14900	COG3979	chitinase
NNW99_RS14910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NNW99_RS15010	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
NNW99_RS15050	COG1316	TRANSCRIPTIONal
NNW99_RS15060	COG2188	Transcriptional regulator
NNW99_RS15180	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NNW99_RS15185	COG1278	Cold shock
NNW99_RS15195	COG2226	methyltransferase
NNW99_RS15200	COG1053	succinate dehydrogenase
NNW99_RS15205	COG4213	ABC transporter substrate-binding protein
NNW99_RS15215	COG0183	Belongs to the thiolase family
NNW99_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS15235	COG1309	transcriptional regulator
NNW99_RS15240	COG1301	dicarboxylic acid transport
NNW99_RS15255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NNW99_RS15265	COG0163	prenyltransferase activity
NNW99_RS15280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NNW99_RS15310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NNW99_RS15325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NNW99_RS15330	COG1333	cytochrome c biogenesis protein
NNW99_RS15335	COG0785	Cytochrome C biogenesis protein
NNW99_RS15340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NNW99_RS15350	COG0406	alpha-ribazole phosphatase activity
NNW99_RS15355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NNW99_RS15365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NNW99_RS15395	COG1309	transcriptional regulator
NNW99_RS15415	COG2828	Protein conserved in bacteria
NNW99_RS15420	COG0583	DNA-binding transcription factor activity
NNW99_RS15450	COG0642	Histidine kinase
NNW99_RS15450	COG3850	Histidine kinase
NNW99_RS15460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS15475	COG1742	UPF0060 membrane protein
NNW99_RS15495	COG1690	Belongs to the RtcB family
NNW99_RS15515	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NNW99_RS15520	COG0018	arginyl-trna synthetase
NNW99_RS15540	COG2318	DinB family
NNW99_RS15570	COG0113	porphobilinogen synthase activity
NNW99_RS15580	COG1648	precorrin-2 dehydrogenase activity
NNW99_RS15580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NNW99_RS15585	COG0181	hydroxymethylbilane synthase activity
NNW99_RS15590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NNW99_RS15595	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NNW99_RS15645	COG0123	including yeast histone deacetylase and acetoin utilization protein
NNW99_RS15650	COG0738	Major facilitator superfamily
NNW99_RS15675	COG0180	Tryptophanyl-tRNA synthetase
NNW99_RS15680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NNW99_RS15690	COG1129	ABC transporter
NNW99_RS15690	COG0842	Transport permease protein
NNW99_RS15705	COG4991	sh3 domain protein
NNW99_RS15710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NNW99_RS15710	COG0515	serine threonine protein kinase
NNW99_RS15715	COG0129	dihydroxy-acid dehydratase activity
NNW99_RS15725	COG1082	Xylose isomerase domain protein TIM barrel
NNW99_RS15730	COG0248	Ppx GppA phosphatase
NNW99_RS15750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NNW99_RS15760	COG0671	phosphoesterase, PA-phosphatase related
NNW99_RS15770	COG4585	Histidine kinase
NNW99_RS15775	COG1194	a g-specific adenine glycosylase
NNW99_RS15780	COG1595	DNA-templated transcription, initiation
NNW99_RS15790	COG0745	RESPONSE REGULATOR receiver
NNW99_RS15795	COG2205	protein histidine kinase activity
NNW99_RS15800	COG0346	lactoylglutathione lyase activity
NNW99_RS15820	COG0739	heme binding
NNW99_RS15820	COG0741	lytic transglycosylase activity
NNW99_RS15820	COG1196	nuclear chromosome segregation
NNW99_RS15845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NNW99_RS15865	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NNW99_RS15875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NNW99_RS15880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NNW99_RS15900	COG0640	Transcriptional regulator
NNW99_RS15920	COG0649	NAD binding
NNW99_RS15945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NNW99_RS15945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NNW99_RS15960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NNW99_RS15975	COG0302	gtp cyclohydrolase
NNW99_RS15990	COG0037	tRNA processing
NNW99_RS16000	COG2027	D-alanyl-D-alanine carboxypeptidase
NNW99_RS16005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NNW99_RS16015	COG0586	Pfam SNARE associated Golgi protein
NNW99_RS16020	COG0393	Putative heavy-metal-binding
NNW99_RS16065	COG1132	(ABC) transporter
NNW99_RS16070	COG0789	Transcriptional regulator
NNW99_RS16080	COG0076	glutamate decarboxylase activity
NNW99_RS16090	COG2318	DinB family
NNW99_RS16095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NNW99_RS16100	COG0386	Belongs to the glutathione peroxidase family
NNW99_RS16140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NNW99_RS16145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NNW99_RS16195	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NNW99_RS16290	COG0667	Aldo Keto reductase
NNW99_RS16305	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS16325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NNW99_RS16335	COG0254	rRNA binding
NNW99_RS16340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NNW99_RS16345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NNW99_RS16350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NNW99_RS16375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NNW99_RS16375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NNW99_RS16380	COG3629	intracellular signal transduction
NNW99_RS16380	COG3903	Transcriptional regulator
NNW99_RS16390	COG2207	Transcriptional regulator
NNW99_RS16390	COG3708	Transcriptional regulator
NNW99_RS16415	COG0419	ATPase involved in DNA repair
NNW99_RS16475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NNW99_RS16480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NNW99_RS16480	COG1754	DNA topoisomerase type I activity
NNW99_RS16500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NNW99_RS16510	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS16515	COG1111	helicase
NNW99_RS16515	COG1205	dead DEAH box helicase
NNW99_RS16585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NNW99_RS16590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NNW99_RS16600	COG2267	carboxylic ester hydrolase activity
NNW99_RS16630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NNW99_RS16655	COG0003	Pfam Anion-transporting ATPase
NNW99_RS16675	COG1408	metallophosphoesterase
NNW99_RS16760	COG0701	Predicted permease
NNW99_RS16785	COG1595	DNA-templated transcription, initiation
NNW99_RS16805	COG2205	protein histidine kinase activity
NNW99_RS16825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NNW99_RS16830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NNW99_RS16840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NNW99_RS16855	COG0693	protein deglycase activity
NNW99_RS16860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NNW99_RS16865	COG1802	Transcriptional regulator
NNW99_RS16880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NNW99_RS16900	COG1131	(ABC) transporter
NNW99_RS16905	COG3559	Exporter of polyketide antibiotics
NNW99_RS16915	COG2124	cytochrome p450
NNW99_RS16930	COG2197	response regulator
NNW99_RS16935	COG4585	Histidine kinase
NNW99_RS16940	COG2197	response regulator
NNW99_RS16945	COG4585	Histidine kinase
NNW99_RS16965	COG3844	kynureninase activity
NNW99_RS16980	COG0477	Major facilitator Superfamily
NNW99_RS16985	COG0191	fructose-bisphosphate aldolase activity
NNW99_RS16990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NNW99_RS17005	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NNW99_RS17030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NNW99_RS17055	COG0577	efflux transmembrane transporter activity
NNW99_RS17055	COG1136	(ABC) transporter
NNW99_RS17060	COG0577	efflux transmembrane transporter activity
NNW99_RS17060	COG1136	(ABC) transporter
NNW99_RS17070	COG2205	protein histidine kinase activity
NNW99_RS17075	COG0745	RESPONSE REGULATOR receiver
NNW99_RS17100	COG4152	abc transporter atp-binding protein
NNW99_RS17110	COG0515	serine threonine protein kinase
NNW99_RS17140	COG1454	alcohol dehydrogenase
NNW99_RS17145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNW99_RS17160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS17185	COG0542	response to heat
NNW99_RS17215	COG2311	Membrane
NNW99_RS17220	COG4213	ABC transporter substrate-binding protein
NNW99_RS17225	COG0789	Transcriptional regulator
NNW99_RS17230	COG0484	heat shock protein binding
NNW99_RS17235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NNW99_RS17240	COG0443	Heat shock 70 kDa protein
NNW99_RS17245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NNW99_RS17250	COG0247	lactate metabolic process
NNW99_RS17250	COG2181	nitrate reductase activity
NNW99_RS17300	COG1733	regulation of RNA biosynthetic process
NNW99_RS17305	COG1902	pentaerythritol trinitrate reductase activity
NNW99_RS17310	COG0604	alcohol dehydrogenase
NNW99_RS17315	COG1733	regulation of RNA biosynthetic process
NNW99_RS17380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NNW99_RS17385	COG0717	Belongs to the dCTP deaminase family
NNW99_RS17450	COG2188	Transcriptional regulator
NNW99_RS17460	COG2188	Transcriptional regulator
NNW99_RS17495	COG1309	transcriptional regulator
NNW99_RS17505	COG1280	lysine exporter protein (LysE YggA)
NNW99_RS17520	COG1191	sigma factor activity
NNW99_RS17550	COG0477	Major facilitator Superfamily
NNW99_RS17570	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
NNW99_RS17595	COG1295	ribonuclease BN
NNW99_RS17615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NNW99_RS17620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NNW99_RS17635	COG1595	DNA-templated transcription, initiation
NNW99_RS17650	COG0477	Major facilitator Superfamily
NNW99_RS17660	COG0656	L-ascorbic acid biosynthetic process
NNW99_RS17735	COG0667	Aldo Keto reductase
NNW99_RS17745	COG3961	Belongs to the TPP enzyme family
NNW99_RS17750	COG1231	oxidoreductase activity
NNW99_RS17755	COG2814	Major facilitator Superfamily
NNW99_RS17760	COG0640	Transcriptional regulator
NNW99_RS17775	COG0577	efflux transmembrane transporter activity
NNW99_RS17775	COG1136	(ABC) transporter
NNW99_RS17785	COG2197	response regulator
NNW99_RS17810	COG4585	Histidine kinase
NNW99_RS17815	COG2197	response regulator
NNW99_RS17825	COG2197	response regulator
NNW99_RS17830	COG4585	Histidine kinase
NNW99_RS17835	COG2409	Drug exporters of the RND superfamily
NNW99_RS17840	COG1278	Cold shock
NNW99_RS17855	COG2072	flavoprotein involved in K transport
NNW99_RS17860	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS17865	COG1309	transcriptional regulator
NNW99_RS17870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS17880	COG1609	Transcriptional regulator
NNW99_RS17885	COG0697	spore germination
NNW99_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS17900	COG0076	glutamate decarboxylase activity
NNW99_RS17915	COG3903	Transcriptional regulator
NNW99_RS17915	COG3629	intracellular signal transduction
NNW99_RS17925	COG0596	Alpha beta hydrolase
NNW99_RS17930	COG3842	ATPase activity
NNW99_RS17955	COG0539	negative regulation of cytoplasmic translation
NNW99_RS17995	COG0714	Associated with various cellular activities
NNW99_RS18045	COG2367	Beta-lactamase
NNW99_RS18065	COG1132	(ABC) transporter
NNW99_RS18070	COG1309	transcriptional regulator
NNW99_RS18105	COG0366	Alpha amylase catalytic
NNW99_RS18120	COG1957	nucleoside hydrolase
NNW99_RS18145	COG0701	Predicted permease
NNW99_RS18165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NNW99_RS18195	COG1653	transport
NNW99_RS18225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NNW99_RS18245	COG0583	DNA-binding transcription factor activity
NNW99_RS18260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NNW99_RS18290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NNW99_RS18320	COG1741	Belongs to the pirin family
NNW99_RS18325	COG0477	Major facilitator Superfamily
NNW99_RS18345	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS18350	COG1362	aminopeptidase activity
NNW99_RS18400	COG2814	Major facilitator Superfamily
NNW99_RS18415	COG0508	dehydrogenase complex catalyzes the overall conversion of
NNW99_RS18420	COG0022	dehydrogenase e1 component
NNW99_RS18430	COG0515	serine threonine protein kinase
NNW99_RS18435	COG0515	serine threonine protein kinase
NNW99_RS18455	COG0604	alcohol dehydrogenase
NNW99_RS18455	COG3321	synthase
NNW99_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS18500	COG1522	sequence-specific DNA binding
NNW99_RS18505	COG1309	transcriptional regulator
NNW99_RS18510	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNW99_RS18575	COG2197	response regulator
NNW99_RS18585	COG0577	efflux transmembrane transporter activity
NNW99_RS18585	COG1136	(ABC) transporter
NNW99_RS18600	COG1131	(ABC) transporter
NNW99_RS18610	COG1716	ATPase activity
NNW99_RS18615	COG1716	ATPase activity
NNW99_RS18630	COG0768	penicillin binding
NNW99_RS18635	COG0515	serine threonine protein kinase
NNW99_RS18660	COG3764	Sortase (surface protein transpeptidase)
NNW99_RS18665	COG3764	Sortase (surface protein transpeptidase)
NNW99_RS18680	COG3764	Sortase (surface protein transpeptidase)
NNW99_RS18695	COG0705	Rhomboid family
NNW99_RS18710	COG2226	methyltransferase
NNW99_RS18725	COG0488	(ABC) transporter
NNW99_RS18750	COG0515	serine threonine protein kinase
NNW99_RS18780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NNW99_RS18785	COG0187	DNA topoisomerase II activity
NNW99_RS18790	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NNW99_RS18795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NNW99_RS18800	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NNW99_RS18805	COG0592	DNA-directed DNA polymerase activity
NNW99_RS18810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NNW99_RS18820	COG0594	ribonuclease P activity
NNW99_RS18825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NNW99_RS18830	COG0706	membrane insertase activity
NNW99_RS18840	COG0357	Ribosomal RNA small subunit methyltransferase G
NNW99_RS18845	COG1192	Involved in chromosome partitioning
NNW99_RS18860	COG3118	belongs to the thioredoxin family
NNW99_RS18865	COG0492	ferredoxin-NADP+ reductase activity
NNW99_RS18875	COG1595	DNA-templated transcription, initiation
NNW99_RS18880	COG2815	serine threonine protein kinase
NNW99_RS18880	COG0515	serine threonine protein kinase
NNW99_RS18895	COG0617	tRNA 3'-terminal CCA addition
NNW99_RS18920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NNW99_RS18945	COG0360	Binds together with S18 to 16S ribosomal RNA
NNW99_RS18950	COG0629	single-stranded DNA binding
NNW99_RS18955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NNW99_RS18960	COG0359	binds to the 23S rRNA
NNW99_RS18970	COG0305	Participates in initiation and elongation during chromosome replication
NNW99_RS18990	COG2814	Major facilitator Superfamily
NNW99_RS19020	COG0626	cystathionine gamma-synthase activity
NNW99_RS19025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NNW99_RS19030	COG1950	PFAM Membrane protein of
NNW99_RS19035	COG0662	Cupin 2, conserved barrel domain protein
NNW99_RS19060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NNW99_RS19090	COG2186	Transcriptional regulator
NNW99_RS19135	COG1609	Transcriptional regulator
NNW99_RS19140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NNW99_RS19150	COG1271	oxidase subunit
NNW99_RS19155	COG1294	oxidase, subunit
NNW99_RS19160	COG4988	ABC transporter
NNW99_RS19165	COG0739	heme binding
NNW99_RS19170	COG0561	phosphatase activity
NNW99_RS19180	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NNW99_RS19220	COG0561	phosphatase activity
NNW99_RS19225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NNW99_RS19230	COG0077	Prephenate dehydratase
NNW99_RS19235	COG2837	iron assimilation
NNW99_RS19270	COG0751	glycine-tRNA ligase activity
NNW99_RS19270	COG0752	glycyl-tRNA synthetase alpha subunit
NNW99_RS19280	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NNW99_RS19285	COG0006	proline dipeptidase activity
NNW99_RS19305	COG0653	protein targeting
NNW99_RS19320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NNW99_RS19345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NNW99_RS19360	COG2319	Wd-40 repeat
NNW99_RS19360	COG4249	Peptidase C14 caspase catalytic subunit p20
NNW99_RS19410	COG1595	DNA-templated transcription, initiation
NNW99_RS19415	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS19420	COG2814	Major facilitator Superfamily
NNW99_RS19425	COG1309	transcriptional regulator
NNW99_RS19430	COG0784	Response regulator, receiver
NNW99_RS19460	COG0494	nUDIX hydrolase
NNW99_RS19465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NNW99_RS19490	COG0745	RESPONSE REGULATOR receiver
NNW99_RS19495	COG2205	protein histidine kinase activity
NNW99_RS19505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NNW99_RS19510	COG0477	Major facilitator Superfamily
NNW99_RS19520	COG3467	pyridoxamine 5'-phosphate
NNW99_RS19540	COG2353	YceI-like domain
NNW99_RS19560	COG1191	sigma factor activity
NNW99_RS19565	COG1191	sigma factor activity
NNW99_RS19600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NNW99_RS19615	COG0433	COG0433 Predicted ATPase
NNW99_RS19635	COG2375	cellular response to nickel ion
NNW99_RS19635	COG1132	(ABC) transporter
NNW99_RS19680	COG0640	Transcriptional regulator
NNW99_RS19685	COG0798	PFAM Bile acid sodium symporter
NNW99_RS19690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NNW99_RS19710	COG0151	Belongs to the GarS family
NNW99_RS19725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NNW99_RS19735	COG2197	response regulator
NNW99_RS19770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NNW99_RS19775	COG0047	phosphoribosylformylglycinamidine synthase activity
NNW99_RS19780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NNW99_RS19810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NNW99_RS19820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NNW99_RS19845	COG1643	Atp-dependent helicase
NNW99_RS19850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNW99_RS19885	COG0513	Belongs to the DEAD box helicase family
NNW99_RS19940	COG1191	sigma factor activity
NNW99_RS19955	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS19960	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS19965	COG2172	sigma factor antagonist activity
NNW99_RS19980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NNW99_RS19990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NNW99_RS19990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NNW99_RS20005	COG0667	Aldo Keto reductase
NNW99_RS20015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NNW99_RS20020	COG0579	oxidoreductase
NNW99_RS20050	COG1252	NADH dehydrogenase
NNW99_RS20085	COG2197	response regulator
NNW99_RS20090	COG4585	Histidine kinase
NNW99_RS20100	COG1131	(ABC) transporter
NNW99_RS20155	COG1196	nuclear chromosome segregation
NNW99_RS20155	COG0739	heme binding
NNW99_RS20155	COG0741	lytic transglycosylase activity
NNW99_RS20160	COG0671	phosphoesterase, PA-phosphatase related
NNW99_RS20165	COG0277	FAD linked oxidase domain protein
NNW99_RS20180	COG1937	Protein conserved in bacteria
NNW99_RS20190	COG0306	phosphate transporter
NNW99_RS20195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NNW99_RS20215	COG0406	alpha-ribazole phosphatase activity
NNW99_RS20215	COG0494	nUDIX hydrolase
NNW99_RS20225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NNW99_RS20245	COG1725	Transcriptional regulator
NNW99_RS20260	COG1131	(ABC) transporter
NNW99_RS20280	COG0456	acetyltransferase
NNW99_RS20285	COG0737	Belongs to the 5'-nucleotidase family
NNW99_RS20350	COG2205	protein histidine kinase activity
NNW99_RS20365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NNW99_RS20370	COG1609	Transcriptional regulator
NNW99_RS20375	COG0745	RESPONSE REGULATOR receiver
NNW99_RS20400	COG2897	thiosulfate sulfurtransferase activity
NNW99_RS20420	COG3485	protocatechuate 3,4-dioxygenase
NNW99_RS20430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NNW99_RS20435	COG1490	D-aminoacyl-tRNA deacylase activity
NNW99_RS20445	COG4552	Acetyltransferase involved in intracellular survival and related
NNW99_RS20450	COG2186	Transcriptional regulator
NNW99_RS20470	COG2188	Transcriptional regulator
NNW99_RS20480	COG1309	transcriptional regulator
NNW99_RS20490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NNW99_RS20510	COG2226	methyltransferase
NNW99_RS20525	COG0583	DNA-binding transcription factor activity
NNW99_RS20580	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS20590	COG2207	Transcriptional regulator
NNW99_RS20610	COG2318	DinB family
NNW99_RS20645	COG0588	phosphoglycerate mutase activity
NNW99_RS20670	COG5002	protein histidine kinase activity
NNW99_RS20685	COG1329	Transcriptional regulator
NNW99_RS20690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NNW99_RS20695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NNW99_RS20700	COG0215	cysteine-tRNA ligase activity
NNW99_RS20725	COG3842	ATPase activity
NNW99_RS20880	COG3300	MHYT domain
NNW99_RS20880	COG5001	Diguanylate cyclase
NNW99_RS20925	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NNW99_RS20930	COG0463	Glycosyl transferase, family 2
NNW99_RS20945	COG1278	Cold shock
NNW99_RS21000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NNW99_RS21005	COG1737	Transcriptional regulator
NNW99_RS21060	COG3973	AAA domain
NNW99_RS21070	COG1061	Type III restriction enzyme res subunit
NNW99_RS21115	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NNW99_RS21120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NNW99_RS21130	COG2814	Major facilitator Superfamily
NNW99_RS21155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NNW99_RS21170	COG2252	PERMEase
NNW99_RS21205	COG0667	Aldo Keto reductase
NNW99_RS21225	COG1309	transcriptional regulator
NNW99_RS21240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NNW99_RS21260	COG0596	Alpha beta hydrolase
NNW99_RS21265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NNW99_RS21270	COG0247	lactate metabolic process
NNW99_RS21270	COG0277	FAD linked oxidase domain protein
NNW99_RS21300	COG3467	pyridoxamine 5'-phosphate
NNW99_RS21340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NNW99_RS21355	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS21375	COG0259	pyridoxamine-phosphate oxidase activity
NNW99_RS21395	COG4821	SIS domain
NNW99_RS21405	COG0596	Alpha beta hydrolase
NNW99_RS21405	COG2945	thiolester hydrolase activity
NNW99_RS21415	COG1131	(ABC) transporter
NNW99_RS21455	COG1595	DNA-templated transcription, initiation
NNW99_RS21460	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS21480	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS21485	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS21500	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS21505	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS21510	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NNW99_RS21520	COG2271	Major facilitator Superfamily
NNW99_RS21525	COG3795	YCII-related domain
NNW99_RS21530	COG4941	Belongs to the sigma-70 factor family
NNW99_RS21560	COG2813	Specifically methylates the guanine in position
NNW99_RS21570	COG1024	Enoyl-CoA hydratase
NNW99_RS21580	COG2072	flavoprotein involved in K transport
NNW99_RS21610	COG0259	pyridoxamine-phosphate oxidase activity
NNW99_RS21625	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS21635	COG1309	transcriptional regulator
NNW99_RS21645	COG0515	serine threonine protein kinase
NNW99_RS21645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NNW99_RS21650	COG2267	carboxylic ester hydrolase activity
NNW99_RS21655	COG1024	Enoyl-CoA hydratase
NNW99_RS21680	COG3629	intracellular signal transduction
NNW99_RS21680	COG3903	Transcriptional regulator
NNW99_RS21720	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS21745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NNW99_RS21840	COG1686	Belongs to the peptidase S11 family
NNW99_RS21925	COG1414	Transcriptional regulator
NNW99_RS21945	COG1846	Transcriptional regulator
NNW99_RS21950	COG3384	dioxygenase
NNW99_RS21955	COG1247	-acetyltransferase
NNW99_RS21975	COG0477	Major facilitator Superfamily
NNW99_RS21980	COG1349	DNA-binding transcription factor activity
NNW99_RS21990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NNW99_RS21990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NNW99_RS21990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NNW99_RS22005	COG1376	ErfK ybiS ycfS ynhG family protein
NNW99_RS22025	COG1970	mechanosensitive ion channel activity
NNW99_RS22035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NNW99_RS22060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NNW99_RS22065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NNW99_RS22075	COG0315	cyclic pyranopterin monophosphate synthase activity
NNW99_RS22080	COG0315	cyclic pyranopterin monophosphate synthase activity
NNW99_RS22080	COG0521	Mo-molybdopterin cofactor biosynthetic process
NNW99_RS22085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NNW99_RS22135	COG2072	flavoprotein involved in K transport
NNW99_RS22140	COG2267	carboxylic ester hydrolase activity
NNW99_RS22155	COG0793	Belongs to the peptidase S41A family
NNW99_RS22155	COG4946	Tricorn protease homolog
NNW99_RS22165	COG2409	Drug exporters of the RND superfamily
NNW99_RS22190	COG0442	prolyl-tRNA aminoacylation
NNW99_RS22205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NNW99_RS22210	COG1764	response to oxidative stress
NNW99_RS22215	COG1846	Transcriptional regulator
NNW99_RS22220	COG1122	ATPase activity
NNW99_RS22230	COG0310	cobalt ion transport
NNW99_RS22265	COG0084	hydrolase, TatD family'
NNW99_RS22270	COG3583	domain protein
NNW99_RS22270	COG3584	3D domain protein
NNW99_RS22275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NNW99_RS22280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NNW99_RS22290	COG0488	(ABC) transporter
NNW99_RS22330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NNW99_RS22350	COG2197	response regulator
NNW99_RS22360	COG4106	trans-aconitate 2-methyltransferase activity
NNW99_RS22370	COG1309	transcriptional regulator
NNW99_RS22380	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NNW99_RS22390	COG0193	aminoacyl-tRNA hydrolase activity
NNW99_RS22395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NNW99_RS22400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NNW99_RS22405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NNW99_RS22420	COG4585	Histidine kinase
NNW99_RS22455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NNW99_RS22470	COG0477	Major facilitator Superfamily
NNW99_RS22475	COG1136	(ABC) transporter
NNW99_RS22480	COG0577	efflux transmembrane transporter activity
NNW99_RS22550	COG0148	phosphopyruvate hydratase activity
NNW99_RS22570	COG1252	NADH dehydrogenase
NNW99_RS22575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NNW99_RS22580	COG0577	efflux transmembrane transporter activity
NNW99_RS22585	COG1136	(ABC) transporter
NNW99_RS22620	COG0183	Belongs to the thiolase family
NNW99_RS22625	COG2755	lipolytic protein G-D-S-L family
NNW99_RS22640	COG4221	oxidoreductase activity
NNW99_RS22665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NNW99_RS22680	COG1228	amidohydrolase
NNW99_RS22690	COG1191	sigma factor activity
NNW99_RS22695	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS22715	COG3104	oligopeptide transport
NNW99_RS22720	COG0745	RESPONSE REGULATOR receiver
NNW99_RS22725	COG2205	protein histidine kinase activity
NNW99_RS22740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NNW99_RS22750	COG1902	pentaerythritol trinitrate reductase activity
NNW99_RS22780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NNW99_RS22795	COG1316	TRANSCRIPTIONal
NNW99_RS22805	COG1316	TRANSCRIPTIONal
NNW99_RS22820	COG1316	TRANSCRIPTIONal
NNW99_RS22825	COG1316	TRANSCRIPTIONal
NNW99_RS22830	COG1316	TRANSCRIPTIONal
NNW99_RS22835	COG1316	TRANSCRIPTIONal
NNW99_RS22860	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NNW99_RS22860	COG0778	Nitroreductase
NNW99_RS22865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NNW99_RS22900	COG1620	l-lactate permease
NNW99_RS22905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NNW99_RS22910	COG2835	tetraacyldisaccharide 4'-kinase activity
NNW99_RS22920	COG1482	cell wall glycoprotein biosynthetic process
NNW99_RS22930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NNW99_RS22930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NNW99_RS22930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NNW99_RS22935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NNW99_RS22975	COG0714	Associated with various cellular activities
NNW99_RS22995	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NNW99_RS23000	COG0745	RESPONSE REGULATOR receiver
NNW99_RS23005	COG5000	phosphorelay sensor kinase activity
NNW99_RS23005	COG5002	protein histidine kinase activity
NNW99_RS23010	COG0823	Involved in the tonB-independent uptake of proteins
NNW99_RS23020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NNW99_RS23025	COG2197	response regulator
NNW99_RS23030	COG3214	Protein conserved in bacteria
NNW99_RS23040	COG0653	protein targeting
NNW99_RS23060	COG2902	Dehydrogenase
NNW99_RS23070	COG1215	transferase activity, transferring glycosyl groups
NNW99_RS23075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NNW99_RS23080	COG1134	teichoic acid transport
NNW99_RS23105	COG1846	Transcriptional regulator
NNW99_RS23110	COG1764	response to oxidative stress
NNW99_RS23120	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NNW99_RS23125	COG1216	Glycosyl transferase, family 2
NNW99_RS23130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NNW99_RS23135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NNW99_RS23140	COG0395	ABC-type sugar transport system, permease component
NNW99_RS23145	COG1175	transmembrane transport
NNW99_RS23160	COG0515	serine threonine protein kinase
NNW99_RS23165	COG0515	serine threonine protein kinase
NNW99_RS23170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NNW99_RS23185	COG2884	Cell division ATP-binding protein ftsE
NNW99_RS23195	COG0793	Belongs to the peptidase S41A family
NNW99_RS23200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NNW99_RS23210	COG1501	Belongs to the glycosyl hydrolase 31 family
NNW99_RS23255	COG2223	nitrite transmembrane transporter activity
NNW99_RS23280	COG3973	AAA domain
NNW99_RS23290	COG0776	regulation of translation
NNW99_RS23295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NNW99_RS23300	COG1678	Uncharacterized ACR, COG1678
NNW99_RS23315	COG1175	transmembrane transport
NNW99_RS23320	COG0395	ABC-type sugar transport system, permease component
NNW99_RS23325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NNW99_RS23380	COG3654	unkown
NNW99_RS23415	COG1174	glycine betaine transport
NNW99_RS23420	COG0517	IMP dehydrogenase activity
NNW99_RS23420	COG1125	glycine betaine transport
NNW99_RS23425	COG1174	glycine betaine transport
NNW99_RS23435	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NNW99_RS23445	COG0277	FAD linked oxidase domain protein
NNW99_RS23480	COG1335	isochorismatase
NNW99_RS23490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NNW99_RS23500	COG1113	amino acid transport
NNW99_RS23525	COG1234	tRNA 3'-trailer cleavage
NNW99_RS23530	COG1263	PTS System
NNW99_RS23535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NNW99_RS23540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NNW99_RS23550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NNW99_RS23575	COG1131	(ABC) transporter
NNW99_RS23600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NNW99_RS23620	COG4555	ABC transporter
NNW99_RS23635	COG2733	membrane
NNW99_RS23670	COG0142	geranyltranstransferase activity
NNW99_RS23680	COG2267	carboxylic ester hydrolase activity
NNW99_RS23760	COG0706	membrane insertase activity
NNW99_RS23765	COG0179	Fumarylacetoacetate (FAA) hydrolase
NNW99_RS23775	COG4702	Belongs to the UPF0303 family
NNW99_RS23780	COG0673	inositol 2-dehydrogenase activity
NNW99_RS23835	COG2186	Transcriptional regulator
NNW99_RS23855	COG3397	chitin binding
NNW99_RS23865	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS23880	COG1126	abc transporter atp-binding protein
NNW99_RS23885	COG0765	amino acid transport
NNW99_RS23890	COG0765	amino acid transport
NNW99_RS23895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NNW99_RS23905	COG0154	amidase activity
NNW99_RS23910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NNW99_RS23925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS23975	COG0406	alpha-ribazole phosphatase activity
NNW99_RS23990	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NNW99_RS24000	COG0745	RESPONSE REGULATOR receiver
NNW99_RS24015	COG1175	transmembrane transport
NNW99_RS24020	COG0395	ABC-type sugar transport system, permease component
NNW99_RS24035	COG0395	ABC-type sugar transport system, permease component
NNW99_RS24065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NNW99_RS24070	COG4977	sequence-specific DNA binding
NNW99_RS24080	COG0589	response to stress
NNW99_RS24090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NNW99_RS24125	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NNW99_RS24165	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS24180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NNW99_RS24185	COG1309	transcriptional regulator
NNW99_RS24195	COG1946	Acyl-CoA thioesterase
NNW99_RS24210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NNW99_RS24220	COG0028	Belongs to the TPP enzyme family
NNW99_RS24235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NNW99_RS24235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NNW99_RS24290	COG1472	Belongs to the glycosyl hydrolase 3 family
NNW99_RS24320	COG0673	inositol 2-dehydrogenase activity
NNW99_RS24330	COG2226	methyltransferase
NNW99_RS24340	COG1846	Transcriptional regulator
NNW99_RS24340	COG0456	acetyltransferase
NNW99_RS24355	COG1869	D-ribose catabolic process
NNW99_RS24370	COG1129	ABC transporter
NNW99_RS24435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NNW99_RS24460	COG2409	Drug exporters of the RND superfamily
NNW99_RS24480	COG0657	acetylesterase activity
NNW99_RS24490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NNW99_RS24505	COG3962	Belongs to the TPP enzyme family
NNW99_RS24545	COG0492	ferredoxin-NADP+ reductase activity
NNW99_RS24565	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS24585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NNW99_RS24590	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS24645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NNW99_RS24730	COG1609	Transcriptional regulator
NNW99_RS24805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NNW99_RS24810	COG0629	single-stranded DNA binding
NNW99_RS24825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NNW99_RS24855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NNW99_RS24920	COG1486	melibiose metabolic process
NNW99_RS24925	COG0395	ABC-type sugar transport system, permease component
NNW99_RS24930	COG1175	transmembrane transport
NNW99_RS24935	COG1653	transport
NNW99_RS24940	COG1940	carbohydrate kinase activity
NNW99_RS24945	COG0668	transmembrane transport
NNW99_RS24960	COG1136	(ABC) transporter
NNW99_RS24990	COG1846	Transcriptional regulator
NNW99_RS24995	COG0697	spore germination
NNW99_RS25080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NNW99_RS25095	COG1595	DNA-templated transcription, initiation
NNW99_RS25110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NNW99_RS25120	COG0584	glycerophosphoryl diester phosphodiesterase
NNW99_RS25135	COG3842	ATPase activity
NNW99_RS25140	COG1349	DNA-binding transcription factor activity
NNW99_RS25145	COG3842	ATPase activity
NNW99_RS25150	COG0395	ABC-type sugar transport system, permease component
NNW99_RS25155	COG1175	transmembrane transport
NNW99_RS25160	COG1653	transport
NNW99_RS25165	COG1070	Carbohydrate kinase
NNW99_RS25170	COG0406	alpha-ribazole phosphatase activity
NNW99_RS25180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NNW99_RS25185	COG1113	amino acid transport
NNW99_RS25190	COG1268	BioY protein
NNW99_RS25200	COG0515	serine threonine protein kinase
NNW99_RS25205	COG1113	amino acid transport
NNW99_RS25220	COG4552	Acetyltransferase involved in intracellular survival and related
NNW99_RS25230	COG0577	efflux transmembrane transporter activity
NNW99_RS25230	COG1136	(ABC) transporter
NNW99_RS25245	COG3594	Acyltransferase
NNW99_RS25270	COG2188	Transcriptional regulator
NNW99_RS25345	COG0544	peptidyl-prolyl cis-trans isomerase activity
NNW99_RS25350	COG0740	serine-type endopeptidase activity
NNW99_RS25355	COG0740	serine-type endopeptidase activity
NNW99_RS25360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NNW99_RS25375	COG0525	valine-tRNA ligase activity
NNW99_RS25380	COG0285	dihydrofolate synthase activity
NNW99_RS25390	COG0105	UTP biosynthetic process
NNW99_RS25395	COG1077	Cell shape determining protein MreB Mrl
NNW99_RS25410	COG0768	penicillin binding
NNW99_RS25415	COG0772	Belongs to the SEDS family
NNW99_RS25440	COG3655	Transcriptional regulator
NNW99_RS25460	COG1530	ribonuclease E activity
NNW99_RS25465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NNW99_RS25470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NNW99_RS25475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NNW99_RS25490	COG3540	Alkaline phosphatase
NNW99_RS25505	COG1215	transferase activity, transferring glycosyl groups
NNW99_RS25515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NNW99_RS25525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NNW99_RS25540	COG0501	Belongs to the peptidase M48B family
NNW99_RS25555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NNW99_RS25565	COG0799	negative regulation of ribosome biogenesis
NNW99_RS25570	COG0588	phosphoglycerate mutase activity
NNW99_RS25595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NNW99_RS25605	COG0495	leucyl-tRNA aminoacylation
NNW99_RS25615	COG1307	EDD domain protein, DegV family
NNW99_RS25620	COG1555	photosystem II stabilization
NNW99_RS25625	COG1234	tRNA 3'-trailer cleavage
NNW99_RS25635	COG2353	YceI-like domain
NNW99_RS25655	COG0268	Binds directly to 16S ribosomal RNA
NNW99_RS25660	COG0481	GTPase activity
NNW99_RS25700	COG1420	regulation of RNA biosynthetic process
NNW99_RS25705	COG0484	heat shock protein binding
NNW99_RS25710	COG2070	2-Nitropropane dioxygenase
NNW99_RS25725	COG0793	Belongs to the peptidase S41A family
NNW99_RS25725	COG4946	Tricorn protease homolog
NNW99_RS25730	COG0537	adenosine 5'-monophosphoramidase activity
NNW99_RS25735	COG1234	tRNA 3'-trailer cleavage
NNW99_RS25740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NNW99_RS25775	COG1414	Transcriptional regulator
NNW99_RS25780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNW99_RS25785	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS25790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NNW99_RS25800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NNW99_RS25810	COG2315	Protein conserved in bacteria
NNW99_RS25835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NNW99_RS25845	COG2723	6-phospho-beta-galactosidase activity
NNW99_RS25860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NNW99_RS25870	COG2409	Drug exporters of the RND superfamily
NNW99_RS25875	COG4585	Histidine kinase
NNW99_RS25880	COG2197	response regulator
NNW99_RS25890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNW99_RS25895	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS25910	COG0747	negative chemotaxis
NNW99_RS25915	COG2186	Transcriptional regulator
NNW99_RS25935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NNW99_RS25995	COG1381	Involved in DNA repair and RecF pathway recombination
NNW99_RS26000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NNW99_RS26020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NNW99_RS26025	COG1121	(ABC) transporter
NNW99_RS26030	COG0803	Belongs to the bacterial solute-binding protein 9 family
NNW99_RS26030	COG3443	Belongs to the bacterial solute-binding protein 9 family
NNW99_RS26035	COG0423	glycine-tRNA ligase activity
NNW99_RS26045	COG1280	lysine exporter protein (LysE YggA)
NNW99_RS26050	COG0667	Aldo Keto reductase
NNW99_RS26105	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NNW99_RS26110	COG1940	carbohydrate kinase activity
NNW99_RS26110	COG1846	Transcriptional regulator
NNW99_RS26115	COG0574	Belongs to the PEP-utilizing enzyme family
NNW99_RS26115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NNW99_RS26130	COG0494	nUDIX hydrolase
NNW99_RS26145	COG0642	Histidine kinase
NNW99_RS26150	COG0745	RESPONSE REGULATOR receiver
NNW99_RS26160	COG0659	secondary active sulfate transmembrane transporter activity
NNW99_RS26190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NNW99_RS26190	COG2146	nitrite reductase [NAD(P)H] activity
NNW99_RS26195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NNW99_RS26240	COG0431	NADPH-dependent FMN reductase
NNW99_RS26265	COG0243	molybdopterin cofactor binding
NNW99_RS26275	COG2949	membrane
NNW99_RS26285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NNW99_RS26295	COG0358	DNA primase activity
NNW99_RS26310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NNW99_RS26325	COG1070	Carbohydrate kinase
NNW99_RS26370	COG2197	response regulator
NNW99_RS26415	COG1077	Cell shape determining protein MreB Mrl
NNW99_RS26425	COG2255	four-way junction helicase activity
NNW99_RS26440	COG0825	malonyl-CoA metabolic process
NNW99_RS26440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NNW99_RS26445	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS26455	COG2186	Transcriptional regulator
NNW99_RS26470	COG0477	Major facilitator Superfamily
NNW99_RS26505	COG4981	capsule polysaccharide biosynthetic process
NNW99_RS26535	COG2310	stress, protein
NNW99_RS26540	COG1414	Transcriptional regulator
NNW99_RS26545	COG3386	PFAM SMP-30 Gluconolaconase
NNW99_RS26625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NNW99_RS26635	COG4214	carbohydrate transport
NNW99_RS26640	COG1129	ABC transporter
NNW99_RS26675	COG2130	NADP-dependent
NNW99_RS26680	COG1764	response to oxidative stress
NNW99_RS26725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NNW99_RS26730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NNW99_RS26735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NNW99_RS26750	COG1741	Belongs to the pirin family
NNW99_RS26765	COG0789	Transcriptional regulator
NNW99_RS26770	COG0667	Aldo Keto reductase
NNW99_RS26785	COG1309	transcriptional regulator
NNW99_RS26790	COG0477	Major facilitator Superfamily
NNW99_RS26800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NNW99_RS26805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NNW99_RS26850	COG1358	cellular component organization or biogenesis
NNW99_RS26860	COG0586	Pfam SNARE associated Golgi protein
NNW99_RS26870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NNW99_RS26960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NNW99_RS26980	COG2259	Doxx family
NNW99_RS27010	COG3896	Chloramphenicol phosphotransferase-like protein
NNW99_RS27050	COG4122	O-methyltransferase activity
NNW99_RS27065	COG0477	Major facilitator Superfamily
NNW99_RS27095	COG0183	Belongs to the thiolase family
NNW99_RS27100	COG2124	cytochrome p450
NNW99_RS27115	COG3845	ABC transporter
NNW99_RS27130	COG1657	PFAM Prenyltransferase squalene oxidase
NNW99_RS27165	COG1309	transcriptional regulator
NNW99_RS27170	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS27190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS27200	COG0860	N-Acetylmuramoyl-L-alanine amidase
NNW99_RS27200	COG2247	cell wall binding repeat
NNW99_RS27215	COG0477	Major facilitator Superfamily
NNW99_RS27230	COG2197	response regulator
NNW99_RS27240	COG4585	Histidine kinase
NNW99_RS27245	COG2030	dehydratase
NNW99_RS27255	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS27270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NNW99_RS27285	COG0800	Aldolase
NNW99_RS27290	COG3022	response to hydroperoxide
NNW99_RS27345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NNW99_RS27350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNW99_RS27355	COG0179	Fumarylacetoacetate (FAA) hydrolase
NNW99_RS27380	COG0477	Major facilitator Superfamily
NNW99_RS27400	COG2259	Doxx family
NNW99_RS27410	COG0667	Aldo Keto reductase
NNW99_RS27415	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS27430	COG2814	Major facilitator Superfamily
NNW99_RS27435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NNW99_RS27455	COG1309	transcriptional regulator
NNW99_RS27475	COG0672	)-iron permease
NNW99_RS27480	COG2837	iron assimilation
NNW99_RS27490	COG1120	ATPase activity
NNW99_RS27495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS27505	COG5398	heme oxygenase
NNW99_RS27540	COG1994	Peptidase M50
NNW99_RS27565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NNW99_RS27570	COG0477	Major facilitator Superfamily
NNW99_RS27585	COG2814	Major facilitator Superfamily
NNW99_RS27610	COG0174	glutamine synthetase
NNW99_RS27620	COG1959	2 iron, 2 sulfur cluster binding
NNW99_RS27640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NNW99_RS27640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NNW99_RS27670	COG1309	transcriptional regulator
NNW99_RS27680	COG3226	Transcriptional regulator
NNW99_RS27695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NNW99_RS27705	COG1609	Transcriptional regulator
NNW99_RS27710	COG2182	Extracellular solute-binding protein
NNW99_RS27715	COG1175	transmembrane transport
NNW99_RS27720	COG3833	ABC-type maltose transport systems, permease component
NNW99_RS27725	COG0366	Alpha amylase catalytic
NNW99_RS27760	COG1309	transcriptional regulator
NNW99_RS27795	COG2197	response regulator
NNW99_RS27810	COG0745	RESPONSE REGULATOR receiver
NNW99_RS27845	COG0667	Aldo Keto reductase
NNW99_RS27865	COG0501	Belongs to the peptidase M48B family
NNW99_RS27880	COG2197	response regulator
NNW99_RS27885	COG4585	Histidine kinase
NNW99_RS27890	COG0577	efflux transmembrane transporter activity
NNW99_RS27890	COG1136	(ABC) transporter
NNW99_RS27925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NNW99_RS27930	COG0321	lipoyl(octanoyl) transferase activity
NNW99_RS27945	COG1090	epimerase
NNW99_RS27980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NNW99_RS27990	COG0508	dehydrogenase complex catalyzes the overall conversion of
NNW99_RS27995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NNW99_RS28000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NNW99_RS28030	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NNW99_RS28045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NNW99_RS28065	COG2226	methyltransferase
NNW99_RS28090	COG2197	response regulator
NNW99_RS28095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NNW99_RS28140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NNW99_RS28160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NNW99_RS28170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NNW99_RS28175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NNW99_RS28185	COG1376	ErfK ybiS ycfS ynhG family protein
NNW99_RS28195	COG1845	cytochrome c oxidase, subunit III
NNW99_RS28200	COG2010	Cytochrome c
NNW99_RS28205	COG0723	plastoquinol--plastocyanin reductase activity
NNW99_RS28210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NNW99_RS28215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NNW99_RS28220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NNW99_RS28225	COG1929	Belongs to the glycerate kinase type-1 family
NNW99_RS28235	COG0745	RESPONSE REGULATOR receiver
NNW99_RS28240	COG5002	protein histidine kinase activity
NNW99_RS28290	COG0534	Mate efflux family protein
NNW99_RS28310	COG1022	Amp-dependent synthetase and ligase
NNW99_RS28325	COG0003	Pfam Anion-transporting ATPase
NNW99_RS28335	COG1940	carbohydrate kinase activity
NNW99_RS28360	COG4585	Histidine kinase
NNW99_RS28370	COG0205	6-phosphofructokinase activity
NNW99_RS28380	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NNW99_RS28385	COG0243	molybdopterin cofactor binding
NNW99_RS28390	COG2193	ferroxidase activity
NNW99_RS28395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NNW99_RS28400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NNW99_RS28405	COG0515	serine threonine protein kinase
NNW99_RS28405	COG2815	serine threonine protein kinase
NNW99_RS28410	COG2022	thiamine diphosphate biosynthetic process
NNW99_RS28420	COG2022	thiamine diphosphate biosynthetic process
NNW99_RS28420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNW99_RS28440	COG0352	thiamine-phosphate diphosphorylase activity
NNW99_RS28460	COG1309	transcriptional regulator
NNW99_RS28470	COG1129	ABC transporter
NNW99_RS28480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NNW99_RS28500	COG0714	Associated with various cellular activities
NNW99_RS28510	COG0275	rRNA processing
NNW99_RS28520	COG0768	penicillin binding
NNW99_RS28525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NNW99_RS28530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NNW99_RS28535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NNW99_RS28540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NNW99_RS28550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NNW99_RS28560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NNW99_RS28565	COG1496	oxidoreductase activity
NNW99_RS28575	COG1799	cell septum assembly
NNW99_RS28585	COG3599	regulation of cell shape
NNW99_RS28590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NNW99_RS28600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NNW99_RS28655	COG0587	DNA-directed DNA polymerase activity
NNW99_RS28665	COG1432	Conserved Protein
NNW99_RS28685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NNW99_RS28705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NNW99_RS28710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NNW99_RS28715	COG0131	Imidazoleglycerol-phosphate dehydratase
NNW99_RS28725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NNW99_RS28730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NNW99_RS28735	COG0251	oxidation-reduction process
NNW99_RS28740	COG0107	imidazoleglycerol-phosphate synthase activity
NNW99_RS28750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NNW99_RS28755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NNW99_RS28775	COG0134	indole-3-glycerol-phosphate synthase activity
NNW99_RS28785	COG0133	tryptophan synthase activity
NNW99_RS28790	COG0159	tryptophan synthase activity
NNW99_RS28800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NNW99_RS28810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNW99_RS28840	COG0067	glutamate synthase
NNW99_RS28840	COG0069	glutamate synthase activity
NNW99_RS28840	COG0070	glutamate synthase
NNW99_RS28865	COG1136	(ABC) transporter
NNW99_RS28870	COG2304	oxidoreductase activity
NNW99_RS28875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NNW99_RS28880	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS28885	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS28890	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS28895	COG1309	transcriptional regulator
NNW99_RS28900	COG0183	Belongs to the thiolase family
NNW99_RS28920	COG1024	Enoyl-CoA hydratase
NNW99_RS28930	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS28945	COG0287	Prephenate dehydrogenase
NNW99_RS28945	COG1605	Chorismate mutase
NNW99_RS28950	COG0745	RESPONSE REGULATOR receiver
NNW99_RS28970	COG0737	Belongs to the 5'-nucleotidase family
NNW99_RS28975	COG2968	Membrane
NNW99_RS29025	COG2050	protein possibly involved in aromatic compounds catabolism
NNW99_RS29075	COG0539	negative regulation of cytoplasmic translation
NNW99_RS29085	COG0237	dephospho-CoA kinase activity
NNW99_RS29100	COG2226	methyltransferase
NNW99_RS29135	COG1802	Transcriptional regulator
NNW99_RS29140	COG1953	Uracil, thiamine, allantoin
NNW99_RS29155	COG0251	oxidation-reduction process
NNW99_RS29165	COG0402	S-adenosylhomocysteine deaminase activity
NNW99_RS29210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NNW99_RS29215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NNW99_RS29245	COG0598	Magnesium transport protein CorA
NNW99_RS29260	COG2313	pseudouridylate synthase activity
NNW99_RS29275	COG0584	glycerophosphoryl diester phosphodiesterase
NNW99_RS29285	COG0556	nucleotide-excision repair
NNW99_RS29310	COG0387	Pfam Sodium calcium exchanger
NNW99_RS29315	COG0477	Major facilitator Superfamily
NNW99_RS29320	COG1619	proteins homologs of microcin C7 resistance protein MccF
NNW99_RS29325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NNW99_RS29335	COG0765	amino acid transport
NNW99_RS29340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NNW99_RS29355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NNW99_RS29360	COG2353	YceI-like domain
NNW99_RS29370	COG1105	Belongs to the carbohydrate kinase PfkB family
NNW99_RS29390	COG0322	excinuclease ABC activity
NNW99_RS29395	COG1660	Displays ATPase and GTPase activities
NNW99_RS29400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NNW99_RS29405	COG1481	regulation of sporulation
NNW99_RS29415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NNW99_RS29420	COG0126	phosphoglycerate kinase activity
NNW99_RS29425	COG0149	triose-phosphate isomerase activity
NNW99_RS29430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NNW99_RS29445	COG0166	Belongs to the GPI family
NNW99_RS29455	COG1136	(ABC) transporter
NNW99_RS29460	COG1695	Transcriptional regulator
NNW99_RS29470	COG0366	Alpha amylase catalytic
NNW99_RS29475	COG1653	transport
NNW99_RS29480	COG1175	transmembrane transport
NNW99_RS29485	COG0395	ABC-type sugar transport system, permease component
NNW99_RS29490	COG0363	glucosamine-6-phosphate deaminase activity
NNW99_RS29505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NNW99_RS29515	COG0109	protoheme IX farnesyltransferase activity
NNW99_RS29530	COG1612	heme a metabolic process
NNW99_RS29540	COG1131	(ABC) transporter
NNW99_RS29545	COG2746	aminoglycoside 3-N-acetyltransferase activity
NNW99_RS29560	COG0719	Fe-S assembly protein
NNW99_RS29570	COG0396	ATPase activity
NNW99_RS29575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NNW99_RS29580	COG0822	iron-sulfur transferase activity
NNW99_RS29585	COG2151	metal-sulfur cluster biosynthetic enzyme
NNW99_RS29595	COG2076	Multidrug Resistance protein
NNW99_RS29600	COG3226	Transcriptional regulator
NNW99_RS29605	COG2171	N-acyltransferase activity
NNW99_RS29615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNW99_RS29655	COG1802	Transcriptional regulator
NNW99_RS29670	COG1609	Transcriptional regulator
NNW99_RS29680	COG1175	transmembrane transport
NNW99_RS29685	COG0395	ABC-type sugar transport system, permease component
NNW99_RS29695	COG1309	transcriptional regulator
NNW99_RS29710	COG2045	Belongs to the ComB family
NNW99_RS29715	COG1063	alcohol dehydrogenase
NNW99_RS29720	COG0395	ABC-type sugar transport system, permease component
NNW99_RS29740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NNW99_RS29745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNW99_RS29770	COG1802	Transcriptional regulator
NNW99_RS29785	COG1175	transmembrane transport
NNW99_RS29790	COG0395	ABC-type sugar transport system, permease component
NNW99_RS29795	COG3866	Pectate lyase
NNW99_RS29810	COG3507	Belongs to the glycosyl hydrolase 43 family
NNW99_RS29815	COG4677	pectinesterase activity
NNW99_RS29825	COG2755	lipolytic protein G-D-S-L family
NNW99_RS29835	COG4677	pectinesterase activity
NNW99_RS29855	COG4733	cellulase activity
NNW99_RS29875	COG1595	DNA-templated transcription, initiation
NNW99_RS29880	COG2252	PERMEase
NNW99_RS29885	COG0768	penicillin binding
NNW99_RS29890	COG2197	response regulator
NNW99_RS29895	COG4585	Histidine kinase
NNW99_RS29910	COG1414	Transcriptional regulator
NNW99_RS29930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NNW99_RS29940	COG5285	phytanoyl-CoA dioxygenase
NNW99_RS29945	COG1917	Cupin 2, conserved barrel domain protein
NNW99_RS29950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NNW99_RS29955	COG0456	acetyltransferase
NNW99_RS29960	COG2318	DinB family
NNW99_RS29965	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NNW99_RS29985	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NNW99_RS29995	COG1797	cobyrinic acid a,c-diamide synthase activity
NNW99_RS30010	COG1492	cobalamin metabolic process
NNW99_RS30015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NNW99_RS30035	COG0235	Class ii aldolase
NNW99_RS30055	COG0488	(ABC) transporter
NNW99_RS30105	COG3387	PFAM Glycoside hydrolase 15-related
NNW99_RS30125	COG1966	Carbon starvation protein
NNW99_RS30140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NNW99_RS30160	COG1404	Belongs to the peptidase S8 family
NNW99_RS30175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NNW99_RS30180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NNW99_RS30195	COG2261	transglycosylase associated protein
NNW99_RS30200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NNW99_RS30230	COG2186	Transcriptional regulator
NNW99_RS30235	COG2807	transmembrane transport
NNW99_RS30250	COG0588	phosphoglycerate mutase activity
NNW99_RS30255	COG0560	Phosphoserine phosphatase
NNW99_RS30255	COG3830	Belongs to the UPF0237 family
NNW99_RS30265	COG0842	Transport permease protein
NNW99_RS30265	COG1716	ATPase activity
NNW99_RS30265	COG1131	(ABC) transporter
NNW99_RS30275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NNW99_RS30290	COG2197	response regulator
NNW99_RS30305	COG1119	ATPase activity
NNW99_RS30325	COG1881	PFAM PEBP family protein
NNW99_RS30335	COG2094	Belongs to the DNA glycosylase MPG family
NNW99_RS30370	COG0647	UMP catabolic process
NNW99_RS30375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS30380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS30385	COG1120	ATPase activity
NNW99_RS30405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NNW99_RS30410	COG0497	DNA recombination
NNW99_RS30415	COG0297	glycogen (starch) synthase activity
NNW99_RS30430	COG3387	PFAM Glycoside hydrolase 15-related
NNW99_RS30435	COG0504	CTP synthase activity
NNW99_RS30440	COG0494	nUDIX hydrolase
NNW99_RS30450	COG0686	Belongs to the AlaDH PNT family
NNW99_RS30465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NNW99_RS30470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NNW99_RS30475	COG1187	pseudouridine synthase activity
NNW99_RS30500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NNW99_RS30510	COG1160	GTP binding
NNW99_RS30525	COG3583	domain protein
NNW99_RS30535	COG0411	ABC transporter
NNW99_RS30560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NNW99_RS30570	COG0671	phosphoesterase, PA-phosphatase related
NNW99_RS30580	COG0477	Major facilitator Superfamily
NNW99_RS30585	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS30590	COG1799	cell septum assembly
NNW99_RS30615	COG0587	DNA-directed DNA polymerase activity
NNW99_RS30620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NNW99_RS30625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NNW99_RS30625	COG0662	Cupin 2, conserved barrel domain protein
NNW99_RS30655	COG2226	methyltransferase
NNW99_RS30670	COG1725	Transcriptional regulator
NNW99_RS30685	COG0726	polysaccharide deacetylase
NNW99_RS30690	COG1216	Glycosyl transferase, family 2
NNW99_RS30695	COG0463	Glycosyl transferase, family 2
NNW99_RS30705	COG2755	lipolytic protein G-D-S-L family
NNW99_RS30710	COG0515	serine threonine protein kinase
NNW99_RS30710	COG2815	serine threonine protein kinase
NNW99_RS30730	COG1595	DNA-templated transcription, initiation
NNW99_RS30765	COG2188	Transcriptional regulator
NNW99_RS30770	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NNW99_RS30780	COG1309	transcriptional regulator
NNW99_RS30785	COG0243	molybdopterin cofactor binding
NNW99_RS30790	COG2851	Citrate transporter
NNW99_RS30825	COG0477	Major facilitator Superfamily
NNW99_RS30835	COG0640	Transcriptional regulator
NNW99_RS30845	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS30865	COG0789	Transcriptional regulator
NNW99_RS30890	COG3876	Protein conserved in bacteria
NNW99_RS30900	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS30910	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS30930	COG2149	membrane
NNW99_RS30935	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NNW99_RS30965	COG1063	alcohol dehydrogenase
NNW99_RS30970	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS30980	COG3265	gluconokinase activity
NNW99_RS30985	COG2186	Transcriptional regulator
NNW99_RS30990	COG3012	SEC-C Motif Domain Protein
NNW99_RS30995	COG0308	aminopeptidase N
NNW99_RS31010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NNW99_RS31045	COG0667	Aldo Keto reductase
NNW99_RS31050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS31060	COG0598	Magnesium transport protein CorA
NNW99_RS31065	COG0406	alpha-ribazole phosphatase activity
NNW99_RS31080	COG0215	cysteine-tRNA ligase activity
NNW99_RS31090	COG2186	Transcriptional regulator
NNW99_RS31095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NNW99_RS31100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NNW99_RS31105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NNW99_RS31110	COG1414	Transcriptional regulator
NNW99_RS31115	COG0646	methionine synthase
NNW99_RS31115	COG1410	methionine synthase
NNW99_RS31120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NNW99_RS31125	COG4166	transmembrane transport
NNW99_RS31130	COG0747	negative chemotaxis
NNW99_RS31135	COG2197	response regulator
NNW99_RS31145	COG0517	IMP dehydrogenase activity
NNW99_RS31145	COG1994	Peptidase M50
NNW99_RS31165	COG1222	aaa ATPase
NNW99_RS31170	COG4122	O-methyltransferase activity
NNW99_RS31185	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NNW99_RS31190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NNW99_RS31195	COG1609	Transcriptional regulator
NNW99_RS31205	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NNW99_RS31210	COG0545	Peptidyl-prolyl cis-trans isomerase
NNW99_RS31240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NNW99_RS31245	COG0805	protein transport
NNW99_RS31285	COG0564	pseudouridine synthase activity
NNW99_RS31300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NNW99_RS31305	COG4175	Glycine betaine
NNW99_RS31305	COG0517	IMP dehydrogenase activity
NNW99_RS31310	COG4176	ABC-type proline glycine betaine transport system permease component
NNW99_RS31335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NNW99_RS31340	COG0531	amino acid
NNW99_RS31350	COG0174	glutamine synthetase
NNW99_RS31355	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS31360	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS31395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NNW99_RS31400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NNW99_RS31405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NNW99_RS31410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NNW99_RS31415	COG5002	protein histidine kinase activity
NNW99_RS31420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NNW99_RS31425	COG0072	phenylalanine-tRNA ligase activity
NNW99_RS31425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NNW99_RS31460	COG1649	PFAM Uncharacterised BCR, COG1649
NNW99_RS31470	COG0697	spore germination
NNW99_RS31505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NNW99_RS31510	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NNW99_RS31515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NNW99_RS31520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNW99_RS31525	COG1438	arginine binding
NNW99_RS31540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NNW99_RS31540	COG1017	nitric oxide dioxygenase activity
NNW99_RS31560	COG0137	argininosuccinate synthase activity
NNW99_RS31565	COG0165	Argininosuccinate lyase
NNW99_RS31580	COG0477	Major facilitator Superfamily
NNW99_RS31585	COG0204	Acyl-transferase
NNW99_RS31585	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS31590	COG0584	glycerophosphoryl diester phosphodiesterase
NNW99_RS31620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NNW99_RS31625	COG2011	ABC-type metal ion transport system permease component
NNW99_RS31630	COG1464	Belongs to the NlpA lipoprotein family
NNW99_RS31645	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NNW99_RS31650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NNW99_RS31650	COG1648	precorrin-2 dehydrogenase activity
NNW99_RS31710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NNW99_RS31765	COG1175	transmembrane transport
NNW99_RS31770	COG0395	ABC-type sugar transport system, permease component
NNW99_RS31800	COG2176	DNA-directed DNA polymerase activity
NNW99_RS31800	COG5002	protein histidine kinase activity
NNW99_RS31815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NNW99_RS31835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NNW99_RS31840	COG1560	Kdo2-lipid A biosynthetic process
NNW99_RS31845	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS31875	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NNW99_RS31880	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NNW99_RS31885	COG0217	transcriptional regulatory protein
NNW99_RS31890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NNW99_RS31895	COG0632	four-way junction helicase activity
NNW99_RS31900	COG2255	four-way junction helicase activity
NNW99_RS31910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NNW99_RS31915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NNW99_RS31920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NNW99_RS31925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NNW99_RS31930	COG1196	nuclear chromosome segregation
NNW99_RS31935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NNW99_RS31945	COG0124	histidyl-tRNA synthetase
NNW99_RS31950	COG2197	response regulator
NNW99_RS31955	COG4585	Histidine kinase
NNW99_RS31965	COG1131	(ABC) transporter
NNW99_RS31980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NNW99_RS31995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NNW99_RS32000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NNW99_RS32010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NNW99_RS32020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NNW99_RS32025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NNW99_RS32030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NNW99_RS32040	COG0006	proline dipeptidase activity
NNW99_RS32045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NNW99_RS32050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NNW99_RS32060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NNW99_RS32065	COG0540	Belongs to the ATCase OTCase family
NNW99_RS32070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NNW99_RS32080	COG0505	Belongs to the CarA family
NNW99_RS32085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NNW99_RS32090	COG0167	dihydroorotate dehydrogenase activity
NNW99_RS32095	COG0284	orotidine-5'-phosphate decarboxylase activity
NNW99_RS32105	COG0194	GDP metabolic process
NNW99_RS32110	COG1758	RNA polymerase activity
NNW99_RS32120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NNW99_RS32135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NNW99_RS32145	COG2409	Drug exporters of the RND superfamily
NNW99_RS32150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NNW99_RS32155	COG2390	Transcriptional regulator
NNW99_RS32160	COG2732	(Barnase) inhibitor
NNW99_RS32170	COG0531	amino acid
NNW99_RS32190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NNW99_RS32210	COG2233	PERMEase
NNW99_RS32215	COG2223	nitrite transmembrane transporter activity
NNW99_RS32220	COG1846	Transcriptional regulator
NNW99_RS32220	COG1940	carbohydrate kinase activity
NNW99_RS32225	COG1090	epimerase
NNW99_RS32230	COG1595	DNA-templated transcription, initiation
NNW99_RS32240	COG3201	nicotinamide mononucleotide transporter
NNW99_RS32245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NNW99_RS32245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NNW99_RS32250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NNW99_RS32255	COG0140	phosphoribosyl-ATP diphosphatase activity
NNW99_RS32260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NNW99_RS32310	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS32330	COG1216	Glycosyl transferase, family 2
NNW99_RS32345	COG2270	Major facilitator Superfamily
NNW99_RS32355	COG2364	Membrane
NNW99_RS32360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NNW99_RS32385	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS32390	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS32400	COG1984	allophanate hydrolase subunit 2
NNW99_RS32405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NNW99_RS32410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NNW99_RS32415	COG4336	lyase activity
NNW99_RS32420	COG2814	Major facilitator Superfamily
NNW99_RS32450	COG0531	amino acid
NNW99_RS32455	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS32475	COG1414	Transcriptional regulator
NNW99_RS32480	COG2146	nitrite reductase [NAD(P)H] activity
NNW99_RS32485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NNW99_RS32500	COG2018	Roadblock/LC7 domain
NNW99_RS32520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NNW99_RS32525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NNW99_RS32535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NNW99_RS32545	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NNW99_RS32560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NNW99_RS32570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NNW99_RS32600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NNW99_RS32640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NNW99_RS32650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NNW99_RS32650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NNW99_RS32670	COG1175	transmembrane transport
NNW99_RS32675	COG0395	ABC-type sugar transport system, permease component
NNW99_RS32685	COG1609	Transcriptional regulator
NNW99_RS32760	COG0697	spore germination
NNW99_RS32810	COG0747	negative chemotaxis
NNW99_RS32815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NNW99_RS32830	COG2318	DinB family
NNW99_RS32850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NNW99_RS32865	COG1968	undecaprenyl-diphosphatase activity
NNW99_RS32875	COG0183	Belongs to the thiolase family
NNW99_RS32885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NNW99_RS32910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NNW99_RS32925	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NNW99_RS32940	COG0110	maltose O-acetyltransferase activity
NNW99_RS32965	COG0640	Transcriptional regulator
NNW99_RS32975	COG1832	CoA-binding protein
NNW99_RS32985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NNW99_RS32990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NNW99_RS32995	COG0215	cysteine-tRNA ligase activity
NNW99_RS33010	COG1739	Uncharacterized protein family UPF0029
NNW99_RS33015	COG0420	3'-5' exonuclease activity
NNW99_RS33020	COG0419	ATPase involved in DNA repair
NNW99_RS33040	COG0626	cystathionine gamma-synthase activity
NNW99_RS33055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NNW99_RS33070	COG1595	DNA-templated transcription, initiation
NNW99_RS33080	COG1940	carbohydrate kinase activity
NNW99_RS33085	COG2197	response regulator
NNW99_RS33090	COG4585	Histidine kinase
NNW99_RS33110	COG3663	DNA glycosylase
NNW99_RS33115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NNW99_RS33165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NNW99_RS33170	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NNW99_RS33180	COG0463	Glycosyl transferase, family 2
NNW99_RS33190	COG4310	Domain of unknown function (DUF2172)
NNW99_RS33205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NNW99_RS33215	COG0438	transferase activity, transferring glycosyl groups
NNW99_RS33240	COG0367	asparagine synthase
NNW99_RS33260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NNW99_RS33270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NNW99_RS33285	COG1136	(ABC) transporter
NNW99_RS33300	COG2226	methyltransferase
NNW99_RS33315	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NNW99_RS33320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NNW99_RS33325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NNW99_RS33360	COG0740	serine-type endopeptidase activity
NNW99_RS33370	COG0831	urea catabolic process
NNW99_RS33375	COG0832	Belongs to the urease beta subunit family
NNW99_RS33380	COG0804	urea catabolic process
NNW99_RS33390	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NNW99_RS33395	COG0829	nickel cation binding
NNW99_RS33410	COG0204	Acyl-transferase
NNW99_RS33430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NNW99_RS33435	COG1834	amidinotransferase
NNW99_RS33440	COG1522	sequence-specific DNA binding
NNW99_RS33445	COG3279	Response regulator of the LytR AlgR family
NNW99_RS33455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NNW99_RS33460	COG3275	phosphorelay sensor kinase activity
NNW99_RS33475	COG0205	6-phosphofructokinase activity
NNW99_RS33480	COG3442	glutamine amidotransferase
NNW99_RS33490	COG0242	peptide deformylase activity
NNW99_RS33500	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS33510	COG2124	cytochrome p450
NNW99_RS33530	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS33540	COG1793	dna ligase
NNW99_RS33550	COG1396	sequence-specific DNA binding
NNW99_RS33550	COG3800	Transcriptional regulator
NNW99_RS33560	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS33565	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS33600	COG1846	Transcriptional regulator
NNW99_RS33600	COG1940	carbohydrate kinase activity
NNW99_RS33625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NNW99_RS33685	COG2018	Roadblock/LC7 domain
NNW99_RS33710	COG1946	Acyl-CoA thioesterase
NNW99_RS33725	COG0254	rRNA binding
NNW99_RS33735	COG1132	(ABC) transporter
NNW99_RS33740	COG1132	(ABC) transporter
NNW99_RS33760	COG1132	(ABC) transporter
NNW99_RS33770	COG2072	flavoprotein involved in K transport
NNW99_RS33780	COG1116	anion transmembrane transporter activity
NNW99_RS33785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NNW99_RS33790	COG0432	Pfam Uncharacterised protein family UPF0047
NNW99_RS33850	COG3250	beta-galactosidase activity
NNW99_RS33855	COG0395	ABC-type sugar transport system, permease component
NNW99_RS33860	COG1175	transmembrane transport
NNW99_RS33870	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS33875	COG1802	Transcriptional regulator
NNW99_RS33880	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS33885	COG0800	Aldolase
NNW99_RS33895	COG3386	PFAM SMP-30 Gluconolaconase
NNW99_RS33955	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS33960	COG0800	Aldolase
NNW99_RS33970	COG3386	PFAM SMP-30 Gluconolaconase
NNW99_RS33975	COG0477	Major facilitator Superfamily
NNW99_RS33980	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS33990	COG1653	transport
NNW99_RS34000	COG0395	ABC-type sugar transport system, permease component
NNW99_RS34005	COG1802	Transcriptional regulator
NNW99_RS34010	COG1172	Belongs to the binding-protein-dependent transport system permease family
NNW99_RS34015	COG1129	ABC transporter
NNW99_RS34025	COG1082	Xylose isomerase domain protein TIM barrel
NNW99_RS34035	COG1063	alcohol dehydrogenase
NNW99_RS34040	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS34055	COG1175	transmembrane transport
NNW99_RS34065	COG1609	Transcriptional regulator
NNW99_RS34105	COG1316	TRANSCRIPTIONal
NNW99_RS34125	COG1404	Belongs to the peptidase S8 family
NNW99_RS34155	COG0395	ABC-type sugar transport system, permease component
NNW99_RS34170	COG1609	Transcriptional regulator
NNW99_RS34190	COG2197	response regulator
NNW99_RS34200	COG3345	alpha-galactosidase
NNW99_RS34225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NNW99_RS34245	COG2409	Drug exporters of the RND superfamily
NNW99_RS34250	COG1846	Transcriptional regulator
NNW99_RS34260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNW99_RS34275	COG2208	phosphoserine phosphatase activity
NNW99_RS34285	COG1172	Belongs to the binding-protein-dependent transport system permease family
NNW99_RS34295	COG0446	pyridine nucleotide-disulphide oxidoreductase
NNW99_RS34310	COG3250	beta-galactosidase activity
NNW99_RS34315	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS34325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS34370	COG2124	cytochrome p450
NNW99_RS34390	COG2197	response regulator
NNW99_RS34445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NNW99_RS34480	COG1280	lysine exporter protein (LysE YggA)
NNW99_RS34485	COG1522	sequence-specific DNA binding
NNW99_RS34495	COG0673	inositol 2-dehydrogenase activity
NNW99_RS34505	COG0395	ABC-type sugar transport system, permease component
NNW99_RS34510	COG1175	transmembrane transport
NNW99_RS34520	COG1609	Transcriptional regulator
NNW99_RS34540	COG1396	sequence-specific DNA binding
NNW99_RS34545	COG1335	isochorismatase
NNW99_RS34555	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS34560	COG1250	3-hydroxyacyl-CoA dehydrogenase
NNW99_RS34575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NNW99_RS34580	COG0583	DNA-binding transcription factor activity
NNW99_RS34630	COG3046	protein related to deoxyribodipyrimidine photolyase
NNW99_RS34640	COG0702	epimerase
NNW99_RS34645	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS34665	COG1252	NADH dehydrogenase
NNW99_RS34670	COG1595	DNA-templated transcription, initiation
NNW99_RS34685	COG0745	RESPONSE REGULATOR receiver
NNW99_RS34690	COG0477	Major facilitator Superfamily
NNW99_RS34725	COG3321	synthase
NNW99_RS34725	COG0604	alcohol dehydrogenase
NNW99_RS34725	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS34740	COG4172	Belongs to the ABC transporter superfamily
NNW99_RS34745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS34755	COG0747	negative chemotaxis
NNW99_RS34765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NNW99_RS34815	COG1408	metallophosphoesterase
NNW99_RS34825	COG2318	DinB family
NNW99_RS34865	COG1404	Belongs to the peptidase S8 family
NNW99_RS34895	COG1864	DNA RNA non-specific endonuclease
NNW99_RS34895	COG3591	Belongs to the peptidase S1B family
NNW99_RS34900	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS34945	COG1222	aaa ATPase
NNW99_RS35020	COG4948	Mandelate Racemase Muconate Lactonizing
NNW99_RS35025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NNW99_RS35030	COG0395	ABC-type sugar transport system, permease component
NNW99_RS35035	COG1175	transmembrane transport
NNW99_RS35040	COG1653	transport
NNW99_RS35065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NNW99_RS35105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NNW99_RS35125	COG1674	ftsk spoiiie
NNW99_RS35155	COG0477	Major facilitator Superfamily
NNW99_RS35185	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS35205	COG3509	depolymerase
NNW99_RS35210	COG1902	pentaerythritol trinitrate reductase activity
NNW99_RS35215	COG0640	Transcriptional regulator
NNW99_RS35240	COG1309	transcriptional regulator
NNW99_RS35250	COG0671	phosphoesterase, PA-phosphatase related
NNW99_RS35290	COG0584	glycerophosphoryl diester phosphodiesterase
NNW99_RS35320	COG0204	Acyl-transferase
NNW99_RS35345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NNW99_RS35360	COG0515	serine threonine protein kinase
NNW99_RS35395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NNW99_RS35410	COG1660	Displays ATPase and GTPase activities
NNW99_RS35415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS35420	COG0747	negative chemotaxis
NNW99_RS35425	COG0601	transmembrane transport
NNW99_RS35435	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS35470	COG0445	tRNA wobble uridine modification
NNW99_RS35485	COG4585	Histidine kinase
NNW99_RS35490	COG2197	response regulator
NNW99_RS35515	COG0738	Major facilitator superfamily
NNW99_RS35525	COG0673	inositol 2-dehydrogenase activity
NNW99_RS35535	COG2226	methyltransferase
NNW99_RS35540	COG0789	Transcriptional regulator
NNW99_RS35545	COG1349	DNA-binding transcription factor activity
NNW99_RS35550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NNW99_RS35555	COG3395	kinase activity
NNW99_RS35560	COG0747	negative chemotaxis
NNW99_RS35565	COG0601	transmembrane transport
NNW99_RS35570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS35575	COG0444	Belongs to the ABC transporter superfamily
NNW99_RS35580	COG4608	Belongs to the ABC transporter superfamily
NNW99_RS35585	COG0667	Aldo Keto reductase
NNW99_RS35600	COG1609	Transcriptional regulator
NNW99_RS35620	COG0475	glutathione-regulated potassium exporter activity
NNW99_RS35625	COG2197	response regulator
NNW99_RS35655	COG0326	Molecular chaperone. Has ATPase activity
NNW99_RS35660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NNW99_RS35685	COG4326	sporulation control protein
NNW99_RS35700	COG1175	transmembrane transport
NNW99_RS35720	COG3594	Acyltransferase
NNW99_RS35755	COG4209	transmembrane transport
NNW99_RS35760	COG0395	ABC-type sugar transport system, permease component
NNW99_RS35770	COG1609	Transcriptional regulator
NNW99_RS35795	COG4565	transcriptional regulatory protein
NNW99_RS35805	COG0673	inositol 2-dehydrogenase activity
NNW99_RS35825	COG1175	transmembrane transport
NNW99_RS35830	COG0395	ABC-type sugar transport system, permease component
NNW99_RS35845	COG4106	trans-aconitate 2-methyltransferase activity
NNW99_RS35860	COG3387	PFAM Glycoside hydrolase 15-related
NNW99_RS35870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NNW99_RS35880	COG2813	Specifically methylates the guanine in position
NNW99_RS35890	COG1940	carbohydrate kinase activity
NNW99_RS35895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NNW99_RS35900	COG3467	pyridoxamine 5'-phosphate
NNW99_RS35945	COG1349	DNA-binding transcription factor activity
NNW99_RS35955	COG0464	growth
NNW99_RS35980	COG0463	Glycosyl transferase, family 2
NNW99_RS36010	COG1028	Short-chain dehydrogenase reductase Sdr
NNW99_RS36030	COG3835	regulator
NNW99_RS36035	COG3290	protein histidine kinase activity
NNW99_RS36040	COG2770	Histidine kinase
NNW99_RS36040	COG2208	phosphoserine phosphatase activity
NNW99_RS36075	COG1840	ABC-type Fe3 transport system, periplasmic component
NNW99_RS36105	COG1914	H( )-stimulated, divalent metal cation uptake system
NNW99_RS36120	COG0667	Aldo Keto reductase
NNW99_RS36135	COG2986	histidine ammonia-lyase
NNW99_RS36180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS36205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS36210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS36245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NNW99_RS36265	COG0583	DNA-binding transcription factor activity
NNW99_RS36295	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS36305	COG3842	ATPase activity
NNW99_RS36310	COG1177	transmembrane transport
NNW99_RS36315	COG1176	ABC-type spermidine putrescine transport system, permease component I
NNW99_RS36335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NNW99_RS36345	COG0045	succinate-CoA ligase (ADP-forming) activity
NNW99_RS36345	COG1042	CoA-binding domain protein
NNW99_RS36345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NNW99_RS36350	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS36365	COG1309	transcriptional regulator
NNW99_RS36375	COG1595	DNA-templated transcription, initiation
NNW99_RS36380	COG0281	malic enzyme
NNW99_RS36420	COG0375	protein maturation
NNW99_RS36435	COG0298	carbon dioxide binding
NNW99_RS36440	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NNW99_RS36450	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NNW99_RS36455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NNW99_RS36455	COG1024	Enoyl-CoA hydratase
NNW99_RS36470	COG3507	Belongs to the glycosyl hydrolase 43 family
NNW99_RS36490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NNW99_RS36495	COG0601	transmembrane transport
NNW99_RS36520	COG2319	Wd-40 repeat
NNW99_RS36520	COG4249	Peptidase C14 caspase catalytic subunit p20
NNW99_RS36530	COG2050	protein possibly involved in aromatic compounds catabolism
NNW99_RS36535	COG3396	Phenylacetate-CoA oxygenase
NNW99_RS36540	COG3460	Phenylacetate-CoA oxygenase
NNW99_RS36545	COG3396	Phenylacetate-CoA oxygenase
NNW99_RS36550	COG2151	metal-sulfur cluster biosynthetic enzyme
NNW99_RS36555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NNW99_RS36570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NNW99_RS36575	COG0247	lactate metabolic process
NNW99_RS36575	COG0277	FAD linked oxidase domain protein
NNW99_RS36585	COG1414	Transcriptional regulator
NNW99_RS36590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNW99_RS36595	COG3608	succinylglutamate desuccinylase aspartoacylase
NNW99_RS36605	COG3842	ATPase activity
NNW99_RS36615	COG1177	transmembrane transport
NNW99_RS36620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NNW99_RS36635	COG0667	Aldo Keto reductase
NNW99_RS36645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNW99_RS36645	COG0723	plastoquinol--plastocyanin reductase activity
NNW99_RS36655	COG1609	Transcriptional regulator
NNW99_RS36680	COG3340	Belongs to the peptidase S51 family
NNW99_RS36700	COG0395	ABC-type sugar transport system, permease component
NNW99_RS36705	COG1175	transmembrane transport
NNW99_RS36735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NNW99_RS36740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NNW99_RS36745	COG1968	undecaprenyl-diphosphatase activity
NNW99_RS36750	COG2186	Transcriptional regulator
NNW99_RS36755	COG1113	amino acid transport
NNW99_RS36770	COG2066	Belongs to the glutaminase family
NNW99_RS36785	COG1686	Belongs to the peptidase S11 family
NNW99_RS36790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NNW99_RS36810	COG2226	methyltransferase
NNW99_RS36815	COG2188	Transcriptional regulator
NNW99_RS36820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NNW99_RS36825	COG3458	cephalosporin-C deacetylase activity
NNW99_RS36840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NNW99_RS36845	COG1846	Transcriptional regulator
NNW99_RS36850	COG2890	protein-(glutamine-N5) methyltransferase activity
NNW99_RS36865	COG0446	pyridine nucleotide-disulphide oxidoreductase
NNW99_RS36865	COG1902	pentaerythritol trinitrate reductase activity
NNW99_RS36895	COG1461	Dihydroxyacetone kinase
NNW99_RS36900	COG2376	Dihydroxyacetone kinase
NNW99_RS36930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NNW99_RS36935	COG0483	inositol monophosphate 1-phosphatase activity
NNW99_RS36940	COG0583	DNA-binding transcription factor activity
NNW99_RS36945	COG0745	RESPONSE REGULATOR receiver
NNW99_RS36950	COG2205	protein histidine kinase activity
NNW99_RS36955	COG2409	Drug exporters of the RND superfamily
NNW99_RS36970	COG0202	RNA polymerase activity
NNW99_RS37020	COG0516	GMP reductase activity
NNW99_RS37020	COG0517	IMP dehydrogenase activity
NNW99_RS37080	COG0443	Heat shock 70 kDa protein
NNW99_RS37090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NNW99_RS37120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NNW99_RS37145	COG0574	Belongs to the PEP-utilizing enzyme family
NNW99_RS37145	COG3848	Pyruvate phosphate dikinase
NNW99_RS37155	COG5640	endopeptidase activity
NNW99_RS37190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NNW99_RS37205	COG0129	dihydroxy-acid dehydratase activity
NNW99_RS37220	COG1733	regulation of RNA biosynthetic process
NNW99_RS37225	COG0702	epimerase
NNW99_RS37260	COG0765	amino acid transport
NNW99_RS37265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS37285	COG1126	abc transporter atp-binding protein
NNW99_RS37290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NNW99_RS37295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS37360	COG1960	acyl-CoA dehydrogenase activity
NNW99_RS37365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NNW99_RS37370	COG4569	acetaldehyde dehydrogenase (acetylating) activity
NNW99_RS37375	COG3971	2-oxopent-4-enoate hydratase activity
NNW99_RS37380	COG1414	Transcriptional regulator
NNW99_RS37410	COG1802	Transcriptional regulator
NNW99_RS37415	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NNW99_RS37430	COG1012	belongs to the aldehyde dehydrogenase family
NNW99_RS37445	COG0515	serine threonine protein kinase
NNW99_RS37445	COG2815	serine threonine protein kinase
NNW99_RS37455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NNW99_RS37460	COG2070	2-Nitropropane dioxygenase
NNW99_RS37470	COG2366	antibiotic biosynthetic process
NNW99_RS37475	COG0318	PFAM AMP-dependent synthetase and ligase
NNW99_RS37500	COG1024	Enoyl-CoA hydratase
NNW99_RS37525	COG0589	response to stress
NNW99_RS37580	COG3300	MHYT domain
NNW99_RS37580	COG5001	Diguanylate cyclase
NNW99_RS37610	COG0431	NADPH-dependent FMN reductase
NNW99_RS37645	COG0667	Aldo Keto reductase
NNW99_RS37660	COG0346	lactoylglutathione lyase activity
NNW99_RS37665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NNW99_RS37675	COG0583	DNA-binding transcription factor activity
NNW99_RS37680	COG0667	Aldo Keto reductase
NNW99_RS37695	COG1131	(ABC) transporter
NNW99_RS37695	COG1716	ATPase activity
NNW99_RS37695	COG0842	Transport permease protein
NNW99_RS37740	COG1191	sigma factor activity
NNW99_RS37750	COG0740	serine-type endopeptidase activity
NNW99_RS37755	COG0740	serine-type endopeptidase activity
NNW99_RS37760	COG0596	Alpha beta hydrolase
NNW99_RS37780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NNW99_RS37790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NNW99_RS37800	COG0328	RNA-DNA hybrid ribonuclease activity
NNW99_RS37815	COG0477	Major facilitator Superfamily
NNW99_RS37830	COG0667	Aldo Keto reductase
NNW99_RS37855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS37865	COG0515	serine threonine protein kinase
NNW99_RS37865	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NNW99_RS37875	COG0142	geranyltranstransferase activity
NNW99_RS37890	COG2340	Cysteine-rich secretory protein family
NNW99_RS37900	COG1672	PFAM Archaeal ATPase
NNW99_RS37900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NNW99_RS37910	COG3852	Histidine kinase
NNW99_RS37930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NNW99_RS37950	COG3189	MarR family transcriptional regulator
NNW99_RS38040	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS38045	COG1366	Belongs to the anti-sigma-factor antagonist family
NNW99_RS38070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NNW99_RS38075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NNW99_RS38090	COG0366	Alpha amylase catalytic
NNW99_RS38145	COG0181	hydroxymethylbilane synthase activity
NNW99_RS38160	COG3285	dna ligase
NNW99_RS38160	COG1793	dna ligase
NNW99_RS38170	COG2223	nitrite transmembrane transporter activity
NNW99_RS38175	COG2207	Transcriptional regulator
NNW99_RS38195	COG0656	L-ascorbic acid biosynthetic process
NNW99_RS38200	COG1609	Transcriptional regulator
NNW99_RS38210	COG0395	ABC-type sugar transport system, permease component
NNW99_RS38215	COG1175	transmembrane transport
NNW99_RS38225	COG1621	beta-fructofuranosidase activity
NNW99_RS38240	COG1846	Transcriptional regulator
NNW99_RS38265	COG0009	L-threonylcarbamoyladenylate synthase
NNW99_RS38275	COG2124	cytochrome p450
NNW99_RS38285	COG3845	ABC transporter
NNW99_RS38335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NNW99_RS38380	COG3540	Alkaline phosphatase
NNW99_RS38405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NNW99_RS38420	COG1295	ribonuclease BN
NNW99_RS38425	COG3397	chitin binding
NNW99_RS38440	COG2409	Drug exporters of the RND superfamily
NNW99_RS38505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NNW99_RS38525	COG1090	epimerase
NNW99_RS38570	COG1819	glycosyl
NNW99_RS38585	COG1175	transmembrane transport
NNW99_RS38590	COG0395	ABC-type sugar transport system, permease component
NNW99_RS38640	COG0326	Molecular chaperone. Has ATPase activity
NNW99_RS38675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NNW99_RS38695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NNW99_RS38790	COG0305	Participates in initiation and elongation during chromosome replication
NNW99_RS38815	COG2186	Transcriptional regulator
NNW99_RS38870	COG1196	nuclear chromosome segregation
NNW99_RS38870	COG0741	lytic transglycosylase activity
NNW99_RS38870	COG0739	heme binding