locus-tag	class	description
IAG43_RS00050	COG3629	intracellular signal transduction
IAG43_RS00050	COG3903	Transcriptional regulator
IAG43_RS00060	COG0778	Nitroreductase
IAG43_RS00095	COG3547	Transposase (IS116 IS110 IS902 family)
IAG43_RS00155	COG1595	DNA-templated transcription, initiation
IAG43_RS00180	COG1032	radical SAM domain protein
IAG43_RS00190	COG1064	alcohol dehydrogenase
IAG43_RS00210	COG2274	protein secretion by the type I secretion system
IAG43_RS00220	COG4977	sequence-specific DNA binding
IAG43_RS00285	COG1595	DNA-templated transcription, initiation
IAG43_RS00305	COG3629	intracellular signal transduction
IAG43_RS00305	COG3903	Transcriptional regulator
IAG43_RS00340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG43_RS00380	COG0346	lactoylglutathione lyase activity
IAG43_RS00385	COG0640	Transcriptional regulator
IAG43_RS00400	COG0789	Transcriptional regulator
IAG43_RS00410	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS00415	COG2072	flavoprotein involved in K transport
IAG43_RS00470	COG1595	DNA-templated transcription, initiation
IAG43_RS00505	COG1132	(ABC) transporter
IAG43_RS00515	COG2197	response regulator
IAG43_RS00525	COG1131	(ABC) transporter
IAG43_RS00535	COG0697	spore germination
IAG43_RS00555	COG0738	Major facilitator superfamily
IAG43_RS00560	COG3226	Transcriptional regulator
IAG43_RS00565	COG2197	response regulator
IAG43_RS00570	COG4585	Histidine kinase
IAG43_RS00585	COG4106	trans-aconitate 2-methyltransferase activity
IAG43_RS00595	COG2226	methyltransferase
IAG43_RS00625	COG1228	amidohydrolase
IAG43_RS00655	COG2267	carboxylic ester hydrolase activity
IAG43_RS00675	COG0387	Pfam Sodium calcium exchanger
IAG43_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS00690	COG2814	Major facilitator Superfamily
IAG43_RS00700	COG0745	RESPONSE REGULATOR receiver
IAG43_RS00710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAG43_RS00720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IAG43_RS00735	COG0519	Catalyzes the synthesis of GMP from XMP
IAG43_RS00735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IAG43_RS00740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IAG43_RS00745	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS00760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS00765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS00785	COG4977	sequence-specific DNA binding
IAG43_RS00800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAG43_RS00805	COG1609	Transcriptional regulator
IAG43_RS00810	COG1879	ABC-type sugar transport system periplasmic component
IAG43_RS00820	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAG43_RS00825	COG1129	ABC transporter
IAG43_RS00835	COG3347	Dehydrogenase
IAG43_RS00835	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS00840	COG1070	Carbohydrate kinase
IAG43_RS00875	COG2172	sigma factor antagonist activity
IAG43_RS00875	COG2208	phosphoserine phosphatase activity
IAG43_RS00875	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS00895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IAG43_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS01025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IAG43_RS01030	COG0402	S-adenosylhomocysteine deaminase activity
IAG43_RS01045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS01055	COG0431	NADPH-dependent FMN reductase
IAG43_RS01070	COG0784	Response regulator, receiver
IAG43_RS01070	COG2205	protein histidine kinase activity
IAG43_RS01070	COG5002	protein histidine kinase activity
IAG43_RS01105	COG2249	NAD(P)H dehydrogenase (quinone) activity
IAG43_RS01130	COG1970	mechanosensitive ion channel activity
IAG43_RS01175	COG1295	ribonuclease BN
IAG43_RS01215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IAG43_RS01220	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IAG43_RS01225	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IAG43_RS01245	COG0531	amino acid
IAG43_RS01275	COG0583	DNA-binding transcription factor activity
IAG43_RS01300	COG0789	Transcriptional regulator
IAG43_RS01340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAG43_RS01345	COG0183	Belongs to the thiolase family
IAG43_RS01355	COG1609	Transcriptional regulator
IAG43_RS01370	COG3572	ergothioneine biosynthetic process
IAG43_RS01375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IAG43_RS01380	COG0121	glutamine amidotransferase
IAG43_RS01385	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IAG43_RS01400	COG2182	Extracellular solute-binding protein
IAG43_RS01405	COG3360	Dodecin
IAG43_RS01420	COG0328	RNA-DNA hybrid ribonuclease activity
IAG43_RS01430	COG1733	regulation of RNA biosynthetic process
IAG43_RS01445	COG2208	phosphoserine phosphatase activity
IAG43_RS01445	COG2770	Histidine kinase
IAG43_RS01475	COG2770	Histidine kinase
IAG43_RS01475	COG2208	phosphoserine phosphatase activity
IAG43_RS01485	COG2172	sigma factor antagonist activity
IAG43_RS01490	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS01495	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS01510	COG1278	Cold shock
IAG43_RS01520	COG0666	response to abiotic stimulus
IAG43_RS01540	COG1309	transcriptional regulator
IAG43_RS01585	COG4981	capsule polysaccharide biosynthetic process
IAG43_RS01590	COG0500	methyltransferase
IAG43_RS01625	COG1132	(ABC) transporter
IAG43_RS01630	COG1720	tRNA m6t6A37 methyltransferase activity
IAG43_RS01645	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IAG43_RS01655	COG1454	alcohol dehydrogenase
IAG43_RS01665	COG0494	nUDIX hydrolase
IAG43_RS01690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IAG43_RS01735	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IAG43_RS01740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG43_RS01745	COG0477	Major facilitator Superfamily
IAG43_RS01750	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS01775	COG0515	serine threonine protein kinase
IAG43_RS01775	COG2815	serine threonine protein kinase
IAG43_RS01910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS01925	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG43_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS01965	COG3386	PFAM SMP-30 Gluconolaconase
IAG43_RS01970	COG1414	Transcriptional regulator
IAG43_RS01985	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS01995	COG2755	lipolytic protein G-D-S-L family
IAG43_RS02010	COG2208	phosphoserine phosphatase activity
IAG43_RS02100	COG0277	FAD linked oxidase domain protein
IAG43_RS02120	COG1742	UPF0060 membrane protein
IAG43_RS02160	COG3290	protein histidine kinase activity
IAG43_RS02190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAG43_RS02260	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS02265	COG2366	antibiotic biosynthetic process
IAG43_RS02270	COG0387	Pfam Sodium calcium exchanger
IAG43_RS02275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG43_RS02290	COG2815	serine threonine protein kinase
IAG43_RS02290	COG0515	serine threonine protein kinase
IAG43_RS02300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG43_RS02305	COG1024	Enoyl-CoA hydratase
IAG43_RS02350	COG2226	methyltransferase
IAG43_RS02355	COG1132	(ABC) transporter
IAG43_RS02380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG43_RS02385	COG0583	DNA-binding transcription factor activity
IAG43_RS02410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS02430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAG43_RS02475	COG2205	protein histidine kinase activity
IAG43_RS02475	COG0784	Response regulator, receiver
IAG43_RS02485	COG1191	sigma factor activity
IAG43_RS02495	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS02505	COG2271	Major facilitator Superfamily
IAG43_RS02555	COG3851	Histidine kinase
IAG43_RS02560	COG2197	response regulator
IAG43_RS02565	COG0583	DNA-binding transcription factor activity
IAG43_RS02580	COG4264	IucA IucC family
IAG43_RS02590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAG43_RS02610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IAG43_RS02625	COG2376	Dihydroxyacetone kinase
IAG43_RS02630	COG1461	Dihydroxyacetone kinase
IAG43_RS02640	COG0310	cobalt ion transport
IAG43_RS02645	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
IAG43_RS02655	COG1122	ATPase activity
IAG43_RS02675	COG2226	methyltransferase
IAG43_RS02690	COG0363	glucosamine-6-phosphate deaminase activity
IAG43_RS02750	COG1131	(ABC) transporter
IAG43_RS02750	COG0842	Transport permease protein
IAG43_RS02750	COG1716	ATPase activity
IAG43_RS02800	COG2080	2 iron, 2 sulfur cluster binding
IAG43_RS02805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IAG43_RS02810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG43_RS02830	COG1132	(ABC) transporter
IAG43_RS02870	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG43_RS02880	COG1175	transmembrane transport
IAG43_RS02890	COG1609	Transcriptional regulator
IAG43_RS02895	COG4213	ABC transporter substrate-binding protein
IAG43_RS02905	COG4214	carbohydrate transport
IAG43_RS02960	COG2172	sigma factor antagonist activity
IAG43_RS02960	COG2208	phosphoserine phosphatase activity
IAG43_RS02960	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS02965	COG0435	Glutathione S-transferase
IAG43_RS02990	COG2838	Isocitrate dehydrogenase
IAG43_RS02995	COG0395	ABC-type sugar transport system, permease component
IAG43_RS03000	COG1175	transmembrane transport
IAG43_RS03010	COG0366	Alpha amylase catalytic
IAG43_RS03015	COG1653	transport
IAG43_RS03025	COG1136	(ABC) transporter
IAG43_RS03035	COG2197	response regulator
IAG43_RS03040	COG3851	Histidine kinase
IAG43_RS03100	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS03120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IAG43_RS03125	COG1215	transferase activity, transferring glycosyl groups
IAG43_RS03155	COG1349	DNA-binding transcription factor activity
IAG43_RS03165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAG43_RS03195	COG1940	carbohydrate kinase activity
IAG43_RS03200	COG2223	nitrite transmembrane transporter activity
IAG43_RS03215	COG0644	oxidoreductase
IAG43_RS03225	COG0494	nUDIX hydrolase
IAG43_RS03250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IAG43_RS03270	COG0204	Acyl-transferase
IAG43_RS03295	COG0584	glycerophosphoryl diester phosphodiesterase
IAG43_RS03315	COG0671	phosphoesterase, PA-phosphatase related
IAG43_RS03320	COG1309	transcriptional regulator
IAG43_RS03335	COG0640	Transcriptional regulator
IAG43_RS03340	COG1902	pentaerythritol trinitrate reductase activity
IAG43_RS03350	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IAG43_RS03380	COG1522	sequence-specific DNA binding
IAG43_RS03405	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IAG43_RS03425	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IAG43_RS03445	COG1408	metallophosphoesterase
IAG43_RS03455	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IAG43_RS03460	COG0783	Belongs to the Dps family
IAG43_RS03485	COG5632	N-Acetylmuramoyl-L-alanine amidase
IAG43_RS03485	COG3409	Peptidoglycan-binding domain 1 protein
IAG43_RS03495	COG3537	Alpha-1,2-mannosidase
IAG43_RS03505	COG3634	alkyl hydroperoxide reductase activity
IAG43_RS03510	COG0432	Pfam Uncharacterised protein family UPF0047
IAG43_RS03515	COG2072	flavoprotein involved in K transport
IAG43_RS03540	COG1132	(ABC) transporter
IAG43_RS03545	COG1132	(ABC) transporter
IAG43_RS03560	COG1946	Acyl-CoA thioesterase
IAG43_RS03565	COG0386	Belongs to the glutathione peroxidase family
IAG43_RS03570	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS03580	COG0242	peptide deformylase activity
IAG43_RS03590	COG3442	glutamine amidotransferase
IAG43_RS03595	COG0205	6-phosphofructokinase activity
IAG43_RS03615	COG4608	Belongs to the ABC transporter superfamily
IAG43_RS03620	COG0444	Belongs to the ABC transporter superfamily
IAG43_RS03630	COG0747	negative chemotaxis
IAG43_RS03635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG43_RS03640	COG3458	cephalosporin-C deacetylase activity
IAG43_RS03650	COG2186	Transcriptional regulator
IAG43_RS03655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG43_RS03665	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IAG43_RS03720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAG43_RS03725	COG0204	Acyl-transferase
IAG43_RS03730	COG0829	nickel cation binding
IAG43_RS03735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IAG43_RS03740	COG0830	nickel cation binding
IAG43_RS03745	COG0804	urea catabolic process
IAG43_RS03750	COG0832	Belongs to the urease beta subunit family
IAG43_RS03755	COG0831	urea catabolic process
IAG43_RS03760	COG1309	transcriptional regulator
IAG43_RS03775	COG0740	serine-type endopeptidase activity
IAG43_RS03800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IAG43_RS03805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAG43_RS03810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IAG43_RS03820	COG2226	methyltransferase
IAG43_RS03860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IAG43_RS03865	COG3663	DNA glycosylase
IAG43_RS03875	COG1940	carbohydrate kinase activity
IAG43_RS03900	COG2188	Transcriptional regulator
IAG43_RS03905	COG1595	DNA-templated transcription, initiation
IAG43_RS03925	COG0626	cystathionine gamma-synthase activity
IAG43_RS03945	COG1522	sequence-specific DNA binding
IAG43_RS03950	COG0419	ATPase involved in DNA repair
IAG43_RS03955	COG0420	3'-5' exonuclease activity
IAG43_RS03960	COG1739	Uncharacterized protein family UPF0029
IAG43_RS03965	COG1832	CoA-binding protein
IAG43_RS04005	COG2124	cytochrome p450
IAG43_RS04035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAG43_RS04045	COG1968	undecaprenyl-diphosphatase activity
IAG43_RS04055	COG2813	Specifically methylates the guanine in position
IAG43_RS04060	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IAG43_RS04080	COG2318	DinB family
IAG43_RS04095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IAG43_RS04125	COG0395	ABC-type sugar transport system, permease component
IAG43_RS04130	COG1175	transmembrane transport
IAG43_RS04150	COG1609	Transcriptional regulator
IAG43_RS04180	COG0723	plastoquinol--plastocyanin reductase activity
IAG43_RS04185	COG0583	DNA-binding transcription factor activity
IAG43_RS04190	COG0697	spore germination
IAG43_RS04215	COG1695	Transcriptional regulator
IAG43_RS04220	COG0384	phenazine biosynthesis protein PhzF
IAG43_RS04250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAG43_RS04250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAG43_RS04260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAG43_RS04280	COG1716	ATPase activity
IAG43_RS04300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAG43_RS04330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAG43_RS04340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG43_RS04355	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IAG43_RS04375	COG2018	Roadblock/LC7 domain
IAG43_RS04410	COG2814	Major facilitator Superfamily
IAG43_RS04420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IAG43_RS04425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IAG43_RS04430	COG1984	allophanate hydrolase subunit 2
IAG43_RS04440	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS04470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG43_RS04475	COG2364	Membrane
IAG43_RS04485	COG2270	Major facilitator Superfamily
IAG43_RS04500	COG0463	Glycosyl transferase, family 2
IAG43_RS04520	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS04560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IAG43_RS04565	COG0140	phosphoribosyl-ATP diphosphatase activity
IAG43_RS04570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IAG43_RS04575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAG43_RS04575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAG43_RS04580	COG3201	nicotinamide mononucleotide transporter
IAG43_RS04600	COG1940	carbohydrate kinase activity
IAG43_RS04605	COG0738	Major facilitator superfamily
IAG43_RS04615	COG2233	PERMEase
IAG43_RS04630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAG43_RS04640	COG0531	amino acid
IAG43_RS04650	COG1191	sigma factor activity
IAG43_RS04660	COG2390	Transcriptional regulator
IAG43_RS04665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IAG43_RS04680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAG43_RS04690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IAG43_RS04695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAG43_RS04710	COG0194	GDP metabolic process
IAG43_RS04720	COG0284	orotidine-5'-phosphate decarboxylase activity
IAG43_RS04725	COG0167	dihydroorotate dehydrogenase activity
IAG43_RS04730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAG43_RS04735	COG0505	Belongs to the CarA family
IAG43_RS04745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAG43_RS04750	COG0540	Belongs to the ATCase OTCase family
IAG43_RS04755	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IAG43_RS04765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAG43_RS04770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IAG43_RS04775	COG0006	proline dipeptidase activity
IAG43_RS04785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IAG43_RS04790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IAG43_RS04795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IAG43_RS04800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IAG43_RS04810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAG43_RS04820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IAG43_RS04825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAG43_RS04845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IAG43_RS04865	COG0124	histidyl-tRNA synthetase
IAG43_RS04880	COG1196	nuclear chromosome segregation
IAG43_RS04885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAG43_RS04890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAG43_RS04895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAG43_RS04900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAG43_RS04910	COG2255	four-way junction helicase activity
IAG43_RS04915	COG0632	four-way junction helicase activity
IAG43_RS04920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IAG43_RS04925	COG0217	transcriptional regulatory protein
IAG43_RS04930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IAG43_RS04935	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IAG43_RS04945	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS04950	COG1560	Kdo2-lipid A biosynthetic process
IAG43_RS04955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IAG43_RS04975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IAG43_RS04990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IAG43_RS05070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAG43_RS05070	COG0512	Glutamine amidotransferase of anthranilate synthase
IAG43_RS05130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAG43_RS05130	COG1648	precorrin-2 dehydrogenase activity
IAG43_RS05135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IAG43_RS05150	COG1464	Belongs to the NlpA lipoprotein family
IAG43_RS05155	COG2011	ABC-type metal ion transport system permease component
IAG43_RS05185	COG0584	glycerophosphoryl diester phosphodiesterase
IAG43_RS05190	COG0204	Acyl-transferase
IAG43_RS05190	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS05195	COG0477	Major facilitator Superfamily
IAG43_RS05210	COG0165	Argininosuccinate lyase
IAG43_RS05215	COG0137	argininosuccinate synthase activity
IAG43_RS05235	COG1438	arginine binding
IAG43_RS05240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG43_RS05245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IAG43_RS05250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IAG43_RS05255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IAG43_RS05270	COG0697	spore germination
IAG43_RS05280	COG1649	PFAM Uncharacterised BCR, COG1649
IAG43_RS05300	COG0072	phenylalanine-tRNA ligase activity
IAG43_RS05300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG43_RS05305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IAG43_RS05310	COG5002	protein histidine kinase activity
IAG43_RS05315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAG43_RS05320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IAG43_RS05325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IAG43_RS05330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IAG43_RS05360	COG2910	NAD(P)H-binding
IAG43_RS05365	COG0697	spore germination
IAG43_RS05370	COG1846	Transcriptional regulator
IAG43_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS05390	COG0174	glutamine synthetase
IAG43_RS05395	COG2186	Transcriptional regulator
IAG43_RS05400	COG0531	amino acid
IAG43_RS05405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IAG43_RS05440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAG43_RS05470	COG1595	DNA-templated transcription, initiation
IAG43_RS05485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAG43_RS05490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAG43_RS05515	COG0805	protein transport
IAG43_RS05520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAG43_RS05555	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAG43_RS05570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAG43_RS05575	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAG43_RS05585	COG4122	O-methyltransferase activity
IAG43_RS05590	COG1222	aaa ATPase
IAG43_RS05610	COG1994	Peptidase M50
IAG43_RS05610	COG0517	IMP dehydrogenase activity
IAG43_RS05620	COG2197	response regulator
IAG43_RS05635	COG1410	methionine synthase
IAG43_RS05635	COG0646	methionine synthase
IAG43_RS05640	COG1414	Transcriptional regulator
IAG43_RS05645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAG43_RS05650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IAG43_RS05655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAG43_RS05660	COG2186	Transcriptional regulator
IAG43_RS05670	COG0215	cysteine-tRNA ligase activity
IAG43_RS05685	COG0588	phosphoglycerate mutase activity
IAG43_RS05690	COG0598	Magnesium transport protein CorA
IAG43_RS05700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS05705	COG0667	Aldo Keto reductase
IAG43_RS05735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG43_RS05750	COG0564	pseudouridine synthase activity
IAG43_RS05765	COG1113	amino acid transport
IAG43_RS05770	COG2186	Transcriptional regulator
IAG43_RS05775	COG3265	gluconokinase activity
IAG43_RS05820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IAG43_RS05825	COG2149	membrane
IAG43_RS05850	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS05880	COG3876	Protein conserved in bacteria
IAG43_RS05905	COG0789	Transcriptional regulator
IAG43_RS05925	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS05935	COG0640	Transcriptional regulator
IAG43_RS06015	COG3842	ATPase activity
IAG43_RS06035	COG2851	Citrate transporter
IAG43_RS06040	COG0243	molybdopterin cofactor binding
IAG43_RS06045	COG1309	transcriptional regulator
IAG43_RS06050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IAG43_RS06055	COG2188	Transcriptional regulator
IAG43_RS06065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG43_RS06080	COG2755	lipolytic protein G-D-S-L family
IAG43_RS06090	COG1725	Transcriptional regulator
IAG43_RS06120	COG4565	transcriptional regulatory protein
IAG43_RS06140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAG43_RS06145	COG0587	DNA-directed DNA polymerase activity
IAG43_RS06170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS06175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS06180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG43_RS06185	COG1126	abc transporter atp-binding protein
IAG43_RS06190	COG0765	amino acid transport
IAG43_RS06200	COG0765	amino acid transport
IAG43_RS06210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG43_RS06220	COG1799	cell septum assembly
IAG43_RS06225	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS06235	COG0671	phosphoesterase, PA-phosphatase related
IAG43_RS06250	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS06265	COG2197	response regulator
IAG43_RS06270	COG4585	Histidine kinase
IAG43_RS06280	COG1160	GTP binding
IAG43_RS06290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IAG43_RS06300	COG3547	Transposase (IS116 IS110 IS902 family)
IAG43_RS06310	COG1309	transcriptional regulator
IAG43_RS06320	COG0723	plastoquinol--plastocyanin reductase activity
IAG43_RS06345	COG1187	pseudouridine synthase activity
IAG43_RS06350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IAG43_RS06355	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IAG43_RS06370	COG0686	Belongs to the AlaDH PNT family
IAG43_RS06380	COG0494	nUDIX hydrolase
IAG43_RS06385	COG0504	CTP synthase activity
IAG43_RS06390	COG3387	PFAM Glycoside hydrolase 15-related
IAG43_RS06405	COG0497	DNA recombination
IAG43_RS06410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IAG43_RS06430	COG1120	ATPase activity
IAG43_RS06435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS06440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS06445	COG0647	UMP catabolic process
IAG43_RS06475	COG2094	Belongs to the DNA glycosylase MPG family
IAG43_RS06485	COG1881	PFAM PEBP family protein
IAG43_RS06510	COG1119	ATPase activity
IAG43_RS06525	COG2197	response regulator
IAG43_RS06535	COG0300	oxidoreductase activity
IAG43_RS06540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IAG43_RS06550	COG1716	ATPase activity
IAG43_RS06550	COG1131	(ABC) transporter
IAG43_RS06550	COG0842	Transport permease protein
IAG43_RS06555	COG0560	Phosphoserine phosphatase
IAG43_RS06555	COG3830	Belongs to the UPF0237 family
IAG43_RS06570	COG2807	transmembrane transport
IAG43_RS06575	COG2186	Transcriptional regulator
IAG43_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS06630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IAG43_RS06650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IAG43_RS06655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG43_RS06665	COG1404	Belongs to the peptidase S8 family
IAG43_RS06670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG43_RS06685	COG1199	ATP-dependent helicase activity
IAG43_RS06685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IAG43_RS06700	COG3387	PFAM Glycoside hydrolase 15-related
IAG43_RS06735	COG1024	Enoyl-CoA hydratase
IAG43_RS06745	COG0488	(ABC) transporter
IAG43_RS06770	COG0235	Class ii aldolase
IAG43_RS06785	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IAG43_RS06790	COG1492	cobalamin metabolic process
IAG43_RS06835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IAG43_RS06845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG43_RS06850	COG1917	Cupin 2, conserved barrel domain protein
IAG43_RS06860	COG0156	8-amino-7-oxononanoate synthase activity
IAG43_RS06885	COG1414	Transcriptional regulator
IAG43_RS06890	COG0768	penicillin binding
IAG43_RS06910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG43_RS06915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG43_RS06955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG43_RS06975	COG2171	N-acyltransferase activity
IAG43_RS07000	COG2151	metal-sulfur cluster biosynthetic enzyme
IAG43_RS07005	COG0822	iron-sulfur transferase activity
IAG43_RS07010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAG43_RS07015	COG0396	ATPase activity
IAG43_RS07025	COG0719	Fe-S assembly protein
IAG43_RS07055	COG1612	heme a metabolic process
IAG43_RS07065	COG0109	protoheme IX farnesyltransferase activity
IAG43_RS07075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IAG43_RS07090	COG0363	glucosamine-6-phosphate deaminase activity
IAG43_RS07105	COG0166	Belongs to the GPI family
IAG43_RS07115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAG43_RS07120	COG0149	triose-phosphate isomerase activity
IAG43_RS07125	COG0126	phosphoglycerate kinase activity
IAG43_RS07130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IAG43_RS07135	COG1481	regulation of sporulation
IAG43_RS07140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IAG43_RS07145	COG1660	Displays ATPase and GTPase activities
IAG43_RS07150	COG0322	excinuclease ABC activity
IAG43_RS07170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAG43_RS07205	COG0556	nucleotide-excision repair
IAG43_RS07215	COG0584	glycerophosphoryl diester phosphodiesterase
IAG43_RS07220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAG43_RS07225	COG2814	Major facilitator Superfamily
IAG43_RS07230	COG2313	pseudouridylate synthase activity
IAG43_RS07235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IAG43_RS07235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IAG43_RS07250	COG0436	Aminotransferase
IAG43_RS07295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IAG43_RS07300	COG0330	HflC and HflK could
IAG43_RS07315	COG0237	dephospho-CoA kinase activity
IAG43_RS07330	COG0539	negative regulation of cytoplasmic translation
IAG43_RS07335	COG2226	methyltransferase
IAG43_RS07340	COG1643	Atp-dependent helicase
IAG43_RS07365	COG2050	protein possibly involved in aromatic compounds catabolism
IAG43_RS07420	COG0737	Belongs to the 5'-nucleotidase family
IAG43_RS07440	COG1605	Chorismate mutase
IAG43_RS07440	COG0287	Prephenate dehydrogenase
IAG43_RS07470	COG0513	Belongs to the DEAD box helicase family
IAG43_RS07475	COG1278	Cold shock
IAG43_RS07495	COG0069	glutamate synthase activity
IAG43_RS07495	COG0070	glutamate synthase
IAG43_RS07495	COG0067	glutamate synthase
IAG43_RS07525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG43_RS07530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG43_RS07540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IAG43_RS07550	COG0159	tryptophan synthase activity
IAG43_RS07555	COG0133	tryptophan synthase activity
IAG43_RS07560	COG0134	indole-3-glycerol-phosphate synthase activity
IAG43_RS07585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IAG43_RS07600	COG0107	imidazoleglycerol-phosphate synthase activity
IAG43_RS07605	COG0251	oxidation-reduction process
IAG43_RS07610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IAG43_RS07615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IAG43_RS07625	COG0131	Imidazoleglycerol-phosphate dehydratase
IAG43_RS07630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAG43_RS07635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IAG43_RS07675	COG1432	Conserved Protein
IAG43_RS07685	COG0587	DNA-directed DNA polymerase activity
IAG43_RS07735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IAG43_RS07745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IAG43_RS07760	COG1799	cell septum assembly
IAG43_RS07765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IAG43_RS07780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IAG43_RS07785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAG43_RS07795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IAG43_RS07800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAG43_RS07810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IAG43_RS07815	COG0768	penicillin binding
IAG43_RS07825	COG0275	rRNA processing
IAG43_RS07835	COG0714	Associated with various cellular activities
IAG43_RS07875	COG1131	(ABC) transporter
IAG43_RS07885	COG1309	transcriptional regulator
IAG43_RS07910	COG0352	thiamine-phosphate diphosphorylase activity
IAG43_RS07930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAG43_RS07930	COG2022	thiamine diphosphate biosynthetic process
IAG43_RS07940	COG2022	thiamine diphosphate biosynthetic process
IAG43_RS07945	COG2815	serine threonine protein kinase
IAG43_RS07945	COG0515	serine threonine protein kinase
IAG43_RS07950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IAG43_RS07960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAG43_RS07965	COG2193	ferroxidase activity
IAG43_RS07975	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IAG43_RS07990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAG43_RS08000	COG4585	Histidine kinase
IAG43_RS08025	COG1940	carbohydrate kinase activity
IAG43_RS08035	COG0003	Pfam Anion-transporting ATPase
IAG43_RS08055	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS08075	COG3103	Sh3 type 3 domain protein
IAG43_RS08075	COG0791	NLP P60 protein
IAG43_RS08075	COG1388	LysM domain
IAG43_RS08105	COG2205	protein histidine kinase activity
IAG43_RS08110	COG0745	RESPONSE REGULATOR receiver
IAG43_RS08120	COG1929	Belongs to the glycerate kinase type-1 family
IAG43_RS08125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAG43_RS08130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IAG43_RS08135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IAG43_RS08140	COG0723	plastoquinol--plastocyanin reductase activity
IAG43_RS08145	COG2010	Cytochrome c
IAG43_RS08150	COG1845	cytochrome c oxidase, subunit III
IAG43_RS08160	COG1376	ErfK ybiS ycfS ynhG family protein
IAG43_RS08170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IAG43_RS08175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IAG43_RS08185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG43_RS08205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IAG43_RS08210	COG1086	Polysaccharide biosynthesis protein
IAG43_RS08220	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS08225	COG0297	glycogen (starch) synthase activity
IAG43_RS08235	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS08255	COG1216	Glycosyl transferase, family 2
IAG43_RS08265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAG43_RS08270	COG2197	response regulator
IAG43_RS08275	COG4585	Histidine kinase
IAG43_RS08310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IAG43_RS08315	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IAG43_RS08315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IAG43_RS08330	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IAG43_RS08345	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS08355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IAG43_RS08360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAG43_RS08365	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAG43_RS08380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IAG43_RS08385	COG0515	serine threonine protein kinase
IAG43_RS08385	COG2815	serine threonine protein kinase
IAG43_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS08430	COG0321	lipoyl(octanoyl) transferase activity
IAG43_RS08435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IAG43_RS08490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG43_RS08495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG43_RS08505	COG0673	inositol 2-dehydrogenase activity
IAG43_RS08515	COG0745	RESPONSE REGULATOR receiver
IAG43_RS08535	COG2197	response regulator
IAG43_RS08565	COG0789	Transcriptional regulator
IAG43_RS08600	COG1609	Transcriptional regulator
IAG43_RS08610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IAG43_RS08630	COG0515	serine threonine protein kinase
IAG43_RS08630	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG43_RS08660	COG0395	ABC-type sugar transport system, permease component
IAG43_RS08665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAG43_RS08680	COG0174	glutamine synthetase
IAG43_RS08695	COG2409	Drug exporters of the RND superfamily
IAG43_RS08720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IAG43_RS08720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAG43_RS08725	COG2814	Major facilitator Superfamily
IAG43_RS08735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IAG43_RS08760	COG1994	Peptidase M50
IAG43_RS08790	COG5398	heme oxygenase
IAG43_RS08810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IAG43_RS08815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS08820	COG1120	ATPase activity
IAG43_RS08855	COG2814	Major facilitator Superfamily
IAG43_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS08870	COG0235	Class ii aldolase
IAG43_RS08875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAG43_RS08880	COG1522	sequence-specific DNA binding
IAG43_RS08890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IAG43_RS08970	COG0557	exoribonuclease II activity
IAG43_RS08975	COG3022	response to hydroperoxide
IAG43_RS08980	COG0800	Aldolase
IAG43_RS08995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IAG43_RS09010	COG2197	response regulator
IAG43_RS09045	COG0860	N-Acetylmuramoyl-L-alanine amidase
IAG43_RS09075	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS09080	COG1309	transcriptional regulator
IAG43_RS09100	COG3845	ABC transporter
IAG43_RS09125	COG4122	O-methyltransferase activity
IAG43_RS09350	COG0586	Pfam SNARE associated Golgi protein
IAG43_RS09360	COG1358	cellular component organization or biogenesis
IAG43_RS09405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IAG43_RS09415	COG0477	Major facilitator Superfamily
IAG43_RS09420	COG1309	transcriptional regulator
IAG43_RS09435	COG4585	Histidine kinase
IAG43_RS09440	COG2197	response regulator
IAG43_RS09455	COG0667	Aldo Keto reductase
IAG43_RS09460	COG0789	Transcriptional regulator
IAG43_RS09480	COG2205	protein histidine kinase activity
IAG43_RS09485	COG0745	RESPONSE REGULATOR receiver
IAG43_RS09505	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IAG43_RS09530	COG1741	Belongs to the pirin family
IAG43_RS09545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAG43_RS09550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG43_RS09555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG43_RS09580	COG0515	serine threonine protein kinase
IAG43_RS09595	COG1764	response to oxidative stress
IAG43_RS09600	COG2130	NADP-dependent
IAG43_RS09635	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS09640	COG0825	malonyl-CoA metabolic process
IAG43_RS09640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IAG43_RS09645	COG1404	Belongs to the peptidase S8 family
IAG43_RS09675	COG2003	Belongs to the UPF0758 family
IAG43_RS09725	COG1070	Carbohydrate kinase
IAG43_RS09740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAG43_RS09745	COG0358	DNA primase activity
IAG43_RS09755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IAG43_RS09770	COG2949	membrane
IAG43_RS09780	COG0243	molybdopterin cofactor binding
IAG43_RS09820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAG43_RS09825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAG43_RS09825	COG2146	nitrite reductase [NAD(P)H] activity
IAG43_RS09850	COG0574	Belongs to the PEP-utilizing enzyme family
IAG43_RS09850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAG43_RS09870	COG0667	Aldo Keto reductase
IAG43_RS09880	COG0423	glycine-tRNA ligase activity
IAG43_RS09885	COG0803	Belongs to the bacterial solute-binding protein 9 family
IAG43_RS09885	COG3443	Belongs to the bacterial solute-binding protein 9 family
IAG43_RS09890	COG1121	(ABC) transporter
IAG43_RS09895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAG43_RS09905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAG43_RS09910	COG1381	Involved in DNA repair and RecF pathway recombination
IAG43_RS09915	COG2318	DinB family
IAG43_RS09935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAG43_RS09950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IAG43_RS09965	COG2315	Protein conserved in bacteria
IAG43_RS09975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IAG43_RS09985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG43_RS09990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG43_RS09995	COG1234	tRNA 3'-trailer cleavage
IAG43_RS10000	COG0537	adenosine 5'-monophosphoramidase activity
IAG43_RS10005	COG4946	Tricorn protease homolog
IAG43_RS10005	COG0793	Belongs to the peptidase S41A family
IAG43_RS10025	COG0484	heat shock protein binding
IAG43_RS10030	COG1420	regulation of RNA biosynthetic process
IAG43_RS10060	COG0481	GTPase activity
IAG43_RS10065	COG0268	Binds directly to 16S ribosomal RNA
IAG43_RS10095	COG1307	EDD domain protein, DegV family
IAG43_RS10105	COG0495	leucyl-tRNA aminoacylation
IAG43_RS10115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IAG43_RS10140	COG0588	phosphoglycerate mutase activity
IAG43_RS10145	COG0799	negative regulation of ribosome biogenesis
IAG43_RS10155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IAG43_RS10165	COG0501	Belongs to the peptidase M48B family
IAG43_RS10180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IAG43_RS10190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IAG43_RS10240	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS10260	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS10265	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS10270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IAG43_RS10275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IAG43_RS10280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IAG43_RS10285	COG1530	ribonuclease E activity
IAG43_RS10310	COG0772	Belongs to the SEDS family
IAG43_RS10315	COG0768	penicillin binding
IAG43_RS10330	COG1077	Cell shape determining protein MreB Mrl
IAG43_RS10335	COG0105	UTP biosynthetic process
IAG43_RS10345	COG0285	dihydrofolate synthase activity
IAG43_RS10350	COG0525	valine-tRNA ligase activity
IAG43_RS10360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IAG43_RS10365	COG0740	serine-type endopeptidase activity
IAG43_RS10370	COG0740	serine-type endopeptidase activity
IAG43_RS10375	COG0544	peptidyl-prolyl cis-trans isomerase activity
IAG43_RS10400	COG3594	Acyltransferase
IAG43_RS10405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAG43_RS10410	COG0475	glutathione-regulated potassium exporter activity
IAG43_RS10420	COG4552	Acetyltransferase involved in intracellular survival and related
IAG43_RS10435	COG1113	amino acid transport
IAG43_RS10445	COG1113	amino acid transport
IAG43_RS10450	COG1113	amino acid transport
IAG43_RS10455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IAG43_RS10460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IAG43_RS10475	COG0494	nUDIX hydrolase
IAG43_RS10495	COG5002	protein histidine kinase activity
IAG43_RS10515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAG43_RS10520	COG2124	cytochrome p450
IAG43_RS10550	COG3291	Pkd domain containing protein
IAG43_RS10550	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG43_RS10560	COG0668	transmembrane transport
IAG43_RS10575	COG1175	transmembrane transport
IAG43_RS10580	COG0395	ABC-type sugar transport system, permease component
IAG43_RS10585	COG1486	melibiose metabolic process
IAG43_RS10600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG43_RS10650	COG1136	(ABC) transporter
IAG43_RS10650	COG0577	efflux transmembrane transporter activity
IAG43_RS10675	COG0629	single-stranded DNA binding
IAG43_RS10715	COG1131	(ABC) transporter
IAG43_RS10730	COG3962	Belongs to the TPP enzyme family
IAG43_RS10735	COG3718	enzyme involved in inositol metabolism
IAG43_RS10760	COG2409	Drug exporters of the RND superfamily
IAG43_RS10780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IAG43_RS10790	COG1473	amidohydrolase
IAG43_RS10850	COG0673	inositol 2-dehydrogenase activity
IAG43_RS10855	COG1609	Transcriptional regulator
IAG43_RS10870	COG0697	spore germination
IAG43_RS10880	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG43_RS10910	COG1131	(ABC) transporter
IAG43_RS10915	COG4585	Histidine kinase
IAG43_RS10920	COG2826	transposase and inactivated derivatives, IS30 family
IAG43_RS10925	COG2197	response regulator
IAG43_RS10955	COG0028	Belongs to the TPP enzyme family
IAG43_RS10965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG43_RS11050	COG1946	Acyl-CoA thioesterase
IAG43_RS11060	COG4585	Histidine kinase
IAG43_RS11065	COG2197	response regulator
IAG43_RS11080	COG1309	transcriptional regulator
IAG43_RS11085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG43_RS11100	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS11115	COG0076	glutamate decarboxylase activity
IAG43_RS11120	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IAG43_RS11145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAG43_RS11155	COG0589	response to stress
IAG43_RS11165	COG4977	sequence-specific DNA binding
IAG43_RS11170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IAG43_RS11190	COG1175	transmembrane transport
IAG43_RS11195	COG0395	ABC-type sugar transport system, permease component
IAG43_RS11205	COG0745	RESPONSE REGULATOR receiver
IAG43_RS11230	COG0588	phosphoglycerate mutase activity
IAG43_RS11285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS11305	COG0765	amino acid transport
IAG43_RS11310	COG0765	amino acid transport
IAG43_RS11315	COG1126	abc transporter atp-binding protein
IAG43_RS11335	COG2197	response regulator
IAG43_RS11345	COG3397	chitin binding
IAG43_RS11390	COG0673	inositol 2-dehydrogenase activity
IAG43_RS11395	COG4702	Belongs to the UPF0303 family
IAG43_RS11405	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
IAG43_RS11405	COG0706	membrane insertase activity
IAG43_RS11420	COG1595	DNA-templated transcription, initiation
IAG43_RS11465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IAG43_RS11500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAG43_RS11505	COG2733	membrane
IAG43_RS11520	COG4555	ABC transporter
IAG43_RS11535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAG43_RS11545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IAG43_RS11560	COG0477	Major facilitator Superfamily
IAG43_RS11575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IAG43_RS11585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IAG43_RS11590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAG43_RS11595	COG1263	PTS System
IAG43_RS11600	COG1263	PTS System
IAG43_RS11645	COG1113	amino acid transport
IAG43_RS11655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IAG43_RS11665	COG1335	isochorismatase
IAG43_RS11700	COG0277	FAD linked oxidase domain protein
IAG43_RS11710	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IAG43_RS11750	COG3654	unkown
IAG43_RS11770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG43_RS11785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG43_RS11790	COG0395	ABC-type sugar transport system, permease component
IAG43_RS11810	COG1678	Uncharacterized ACR, COG1678
IAG43_RS11815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAG43_RS11820	COG0776	regulation of translation
IAG43_RS11830	COG3973	AAA domain
IAG43_RS11860	COG0583	DNA-binding transcription factor activity
IAG43_RS11875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IAG43_RS11880	COG0793	Belongs to the peptidase S41A family
IAG43_RS11890	COG2884	Cell division ATP-binding protein ftsE
IAG43_RS11905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IAG43_RS11910	COG0515	serine threonine protein kinase
IAG43_RS11915	COG0515	serine threonine protein kinase
IAG43_RS11925	COG1216	Glycosyl transferase, family 2
IAG43_RS11940	COG2902	Dehydrogenase
IAG43_RS11965	COG0653	protein targeting
IAG43_RS11975	COG3214	Protein conserved in bacteria
IAG43_RS11980	COG2197	response regulator
IAG43_RS11985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IAG43_RS11995	COG0823	Involved in the tonB-independent uptake of proteins
IAG43_RS12000	COG5000	phosphorelay sensor kinase activity
IAG43_RS12000	COG5002	protein histidine kinase activity
IAG43_RS12005	COG0745	RESPONSE REGULATOR receiver
IAG43_RS12030	COG0714	Associated with various cellular activities
IAG43_RS12070	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IAG43_RS12080	COG1482	cell wall glycoprotein biosynthetic process
IAG43_RS12090	COG2835	tetraacyldisaccharide 4'-kinase activity
IAG43_RS12095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAG43_RS12130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IAG43_RS12135	COG0778	Nitroreductase
IAG43_RS12135	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IAG43_RS12165	COG1316	TRANSCRIPTIONal
IAG43_RS12170	COG1316	TRANSCRIPTIONal
IAG43_RS12180	COG1316	TRANSCRIPTIONal
IAG43_RS12190	COG1316	TRANSCRIPTIONal
IAG43_RS12310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAG43_RS12335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IAG43_RS12350	COG2205	protein histidine kinase activity
IAG43_RS12355	COG0745	RESPONSE REGULATOR receiver
IAG43_RS12360	COG3104	oligopeptide transport
IAG43_RS12375	COG1191	sigma factor activity
IAG43_RS12385	COG1228	amidohydrolase
IAG43_RS12400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IAG43_RS12450	COG2755	lipolytic protein G-D-S-L family
IAG43_RS12455	COG0183	Belongs to the thiolase family
IAG43_RS12480	COG4993	Dehydrogenase
IAG43_RS12495	COG1136	(ABC) transporter
IAG43_RS12500	COG1136	(ABC) transporter
IAG43_RS12500	COG0577	efflux transmembrane transporter activity
IAG43_RS12505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAG43_RS12510	COG1252	NADH dehydrogenase
IAG43_RS12545	COG0148	phosphopyruvate hydratase activity
IAG43_RS12550	COG1652	LysM domain
IAG43_RS12580	COG0463	Glycosyl transferase, family 2
IAG43_RS12625	COG0577	efflux transmembrane transporter activity
IAG43_RS12630	COG1136	(ABC) transporter
IAG43_RS12635	COG2814	Major facilitator Superfamily
IAG43_RS12645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG43_RS12670	COG4585	Histidine kinase
IAG43_RS12685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IAG43_RS12690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IAG43_RS12695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IAG43_RS12700	COG0193	aminoacyl-tRNA hydrolase activity
IAG43_RS12715	COG4251	negative regulation of phosphorylation
IAG43_RS12740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IAG43_RS12750	COG1309	transcriptional regulator
IAG43_RS12755	COG4106	trans-aconitate 2-methyltransferase activity
IAG43_RS12760	COG1846	Transcriptional regulator
IAG43_RS12765	COG2197	response regulator
IAG43_RS12770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IAG43_RS12810	COG0488	(ABC) transporter
IAG43_RS12820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IAG43_RS12825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IAG43_RS12830	COG3583	domain protein
IAG43_RS12830	COG3584	3D domain protein
IAG43_RS12835	COG0084	hydrolase, TatD family'
IAG43_RS12865	COG0442	prolyl-tRNA aminoacylation
IAG43_RS12875	COG3739	integral membrane protein
IAG43_RS12880	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS12885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG43_RS12890	COG1764	response to oxidative stress
IAG43_RS12900	COG1122	ATPase activity
IAG43_RS12910	COG0310	cobalt ion transport
IAG43_RS12920	COG2409	Drug exporters of the RND superfamily
IAG43_RS12930	COG4946	Tricorn protease homolog
IAG43_RS12930	COG0793	Belongs to the peptidase S41A family
IAG43_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS12940	COG2267	carboxylic ester hydrolase activity
IAG43_RS12980	COG0521	Mo-molybdopterin cofactor biosynthetic process
IAG43_RS12985	COG0315	cyclic pyranopterin monophosphate synthase activity
IAG43_RS12995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAG43_RS13000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IAG43_RS13025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IAG43_RS13035	COG1970	mechanosensitive ion channel activity
IAG43_RS13055	COG0437	4 iron, 4 sulfur cluster binding
IAG43_RS13060	COG0243	molybdopterin cofactor binding
IAG43_RS13080	COG0477	Major facilitator Superfamily
IAG43_RS13095	COG3384	dioxygenase
IAG43_RS13100	COG1846	Transcriptional regulator
IAG43_RS13135	COG0659	secondary active sulfate transmembrane transporter activity
IAG43_RS13150	COG5293	efflux transmembrane transporter activity
IAG43_RS13160	COG2188	Transcriptional regulator
IAG43_RS13210	COG1686	Belongs to the peptidase S11 family
IAG43_RS13245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAG43_RS13290	COG2205	protein histidine kinase activity
IAG43_RS13305	COG3845	ABC transporter
IAG43_RS13315	COG2124	cytochrome p450
IAG43_RS13330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG43_RS13330	COG0515	serine threonine protein kinase
IAG43_RS13340	COG1309	transcriptional regulator
IAG43_RS13345	COG0259	pyridoxamine-phosphate oxidase activity
IAG43_RS13350	COG2072	flavoprotein involved in K transport
IAG43_RS13375	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS13420	COG1131	(ABC) transporter
IAG43_RS13430	COG0596	Alpha beta hydrolase
IAG43_RS13430	COG2945	thiolester hydrolase activity
IAG43_RS13440	COG4821	SIS domain
IAG43_RS13445	COG0259	pyridoxamine-phosphate oxidase activity
IAG43_RS13470	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS13485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG43_RS13515	COG0583	DNA-binding transcription factor activity
IAG43_RS13520	COG0277	FAD linked oxidase domain protein
IAG43_RS13530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IAG43_RS13600	COG0667	Aldo Keto reductase
IAG43_RS13605	COG2755	lipolytic protein G-D-S-L family
IAG43_RS13620	COG1846	Transcriptional regulator
IAG43_RS13635	COG2252	PERMEase
IAG43_RS13645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IAG43_RS13705	COG2814	Major facilitator Superfamily
IAG43_RS13715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IAG43_RS13720	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IAG43_RS13725	COG1278	Cold shock
IAG43_RS13750	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS13760	COG1061	Type III restriction enzyme res subunit
IAG43_RS13770	COG3973	AAA domain
IAG43_RS13805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IAG43_RS13810	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IAG43_RS13815	COG1136	(ABC) transporter
IAG43_RS13835	COG1404	Belongs to the peptidase S8 family
IAG43_RS13965	COG2161	toxin-antitoxin pair type II binding
IAG43_RS13970	COG4115	mRNA cleavage
IAG43_RS13995	COG0463	Glycosyl transferase, family 2
IAG43_RS14010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG43_RS14010	COG1877	trehalose-phosphatase activity
IAG43_RS14030	COG0402	S-adenosylhomocysteine deaminase activity
IAG43_RS14035	COG1105	Belongs to the carbohydrate kinase PfkB family
IAG43_RS14055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IAG43_RS14080	COG2197	response regulator
IAG43_RS14115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAG43_RS14135	COG3842	ATPase activity
IAG43_RS14145	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IAG43_RS14155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAG43_RS14160	COG0215	cysteine-tRNA ligase activity
IAG43_RS14165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IAG43_RS14170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IAG43_RS14175	COG1329	Transcriptional regulator
IAG43_RS14190	COG5002	protein histidine kinase activity
IAG43_RS14215	COG0588	phosphoglycerate mutase activity
IAG43_RS14220	COG2814	Major facilitator Superfamily
IAG43_RS14235	COG0438	transferase activity, transferring glycosyl groups
IAG43_RS14315	COG0546	phosphoglycolate phosphatase activity
IAG43_RS14320	COG2186	Transcriptional regulator
IAG43_RS14330	COG4552	Acetyltransferase involved in intracellular survival and related
IAG43_RS14345	COG1490	D-aminoacyl-tRNA deacylase activity
IAG43_RS14350	COG0354	folic acid binding
IAG43_RS14360	COG3485	protocatechuate 3,4-dioxygenase
IAG43_RS14395	COG2897	thiosulfate sulfurtransferase activity
IAG43_RS14420	COG0745	RESPONSE REGULATOR receiver
IAG43_RS14425	COG1609	Transcriptional regulator
IAG43_RS14435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG43_RS14440	COG0745	RESPONSE REGULATOR receiver
IAG43_RS14450	COG0488	(ABC) transporter
IAG43_RS14460	COG0737	Belongs to the 5'-nucleotidase family
IAG43_RS14465	COG0456	acetyltransferase
IAG43_RS14470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IAG43_RS14480	COG0406	alpha-ribazole phosphatase activity
IAG43_RS14480	COG0494	nUDIX hydrolase
IAG43_RS14500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IAG43_RS14505	COG0306	phosphate transporter
IAG43_RS14515	COG1937	Protein conserved in bacteria
IAG43_RS14535	COG0277	FAD linked oxidase domain protein
IAG43_RS14540	COG0671	phosphoesterase, PA-phosphatase related
IAG43_RS14545	COG0739	heme binding
IAG43_RS14545	COG1196	nuclear chromosome segregation
IAG43_RS14545	COG0741	lytic transglycosylase activity
IAG43_RS14595	COG3866	Pectate lyase
IAG43_RS14665	COG1131	(ABC) transporter
IAG43_RS14675	COG4585	Histidine kinase
IAG43_RS14680	COG2197	response regulator
IAG43_RS14700	COG1846	Transcriptional regulator
IAG43_RS14740	COG0579	oxidoreductase
IAG43_RS14745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IAG43_RS14755	COG0667	Aldo Keto reductase
IAG43_RS14760	COG1196	nuclear chromosome segregation
IAG43_RS14760	COG0741	lytic transglycosylase activity
IAG43_RS14760	COG0739	heme binding
IAG43_RS14775	COG1595	DNA-templated transcription, initiation
IAG43_RS14780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAG43_RS14780	COG1017	nitric oxide dioxygenase activity
IAG43_RS14785	COG1959	2 iron, 2 sulfur cluster binding
IAG43_RS14810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAG43_RS14815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAG43_RS14845	COG0785	Cytochrome C biogenesis protein
IAG43_RS14850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IAG43_RS14850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IAG43_RS14860	COG1643	Atp-dependent helicase
IAG43_RS14895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IAG43_RS14905	COG3119	arylsulfatase activity
IAG43_RS14920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAG43_RS14925	COG0047	phosphoribosylformylglycinamidine synthase activity
IAG43_RS14930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAG43_RS14965	COG2197	response regulator
IAG43_RS14975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAG43_RS14990	COG0151	Belongs to the GarS family
IAG43_RS15085	COG1309	transcriptional regulator
IAG43_RS15105	COG4941	Belongs to the sigma-70 factor family
IAG43_RS15135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IAG43_RS15170	COG1191	sigma factor activity
IAG43_RS15175	COG1191	sigma factor activity
IAG43_RS15195	COG2353	YceI-like domain
IAG43_RS15200	COG3467	pyridoxamine 5'-phosphate
IAG43_RS15210	COG0477	Major facilitator Superfamily
IAG43_RS15215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IAG43_RS15225	COG2205	protein histidine kinase activity
IAG43_RS15230	COG0745	RESPONSE REGULATOR receiver
IAG43_RS15245	COG2318	DinB family
IAG43_RS15270	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS15275	COG1595	DNA-templated transcription, initiation
IAG43_RS15345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG43_RS15380	COG0006	proline dipeptidase activity
IAG43_RS15400	COG1999	signal sequence binding
IAG43_RS15410	COG2372	response to copper ion
IAG43_RS15415	COG2837	iron assimilation
IAG43_RS15425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IAG43_RS15430	COG0561	phosphatase activity
IAG43_RS15455	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IAG43_RS15465	COG0561	phosphatase activity
IAG43_RS15470	COG0739	heme binding
IAG43_RS15480	COG4988	ABC transporter
IAG43_RS15485	COG1294	oxidase, subunit
IAG43_RS15490	COG1271	oxidase subunit
IAG43_RS15495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAG43_RS15500	COG1609	Transcriptional regulator
IAG43_RS15505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IAG43_RS15515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IAG43_RS15540	COG0662	Cupin 2, conserved barrel domain protein
IAG43_RS15545	COG1950	PFAM Membrane protein of
IAG43_RS15550	COG0626	cystathionine gamma-synthase activity
IAG43_RS15575	COG2814	Major facilitator Superfamily
IAG43_RS15595	COG0305	Participates in initiation and elongation during chromosome replication
IAG43_RS15605	COG0359	binds to the 23S rRNA
IAG43_RS15610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAG43_RS15615	COG0629	single-stranded DNA binding
IAG43_RS15620	COG0360	Binds together with S18 to 16S ribosomal RNA
IAG43_RS15650	COG4499	WXG100 protein secretion system (Wss), protein YukC
IAG43_RS15650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAG43_RS15675	COG0617	tRNA 3'-terminal CCA addition
IAG43_RS15690	COG0515	serine threonine protein kinase
IAG43_RS15690	COG2815	serine threonine protein kinase
IAG43_RS15695	COG1595	DNA-templated transcription, initiation
IAG43_RS15705	COG0492	ferredoxin-NADP+ reductase activity
IAG43_RS15710	COG3118	belongs to the thioredoxin family
IAG43_RS15725	COG1192	Involved in chromosome partitioning
IAG43_RS15730	COG0357	Ribosomal RNA small subunit methyltransferase G
IAG43_RS15740	COG0706	membrane insertase activity
IAG43_RS15745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IAG43_RS15750	COG0594	ribonuclease P activity
IAG43_RS15765	COG0592	DNA-directed DNA polymerase activity
IAG43_RS15770	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IAG43_RS15775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAG43_RS15780	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IAG43_RS15790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAG43_RS15815	COG0515	serine threonine protein kinase
IAG43_RS15830	COG0583	DNA-binding transcription factor activity
IAG43_RS15835	COG0477	Major facilitator Superfamily
IAG43_RS15845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS15855	COG0300	oxidoreductase activity
IAG43_RS15865	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS15890	COG0475	glutathione-regulated potassium exporter activity
IAG43_RS15935	COG0705	Rhomboid family
IAG43_RS15960	COG3764	Sortase (surface protein transpeptidase)
IAG43_RS15965	COG3764	Sortase (surface protein transpeptidase)
IAG43_RS15970	COG0515	serine threonine protein kinase
IAG43_RS15975	COG0768	penicillin binding
IAG43_RS15990	COG1716	ATPase activity
IAG43_RS15995	COG1716	ATPase activity
IAG43_RS16020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAG43_RS16025	COG2151	metal-sulfur cluster biosynthetic enzyme
IAG43_RS16030	COG3396	Phenylacetate-CoA oxygenase
IAG43_RS16035	COG3460	Phenylacetate-CoA oxygenase
IAG43_RS16040	COG3396	Phenylacetate-CoA oxygenase
IAG43_RS16065	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG43_RS16070	COG1309	transcriptional regulator
IAG43_RS16075	COG1522	sequence-specific DNA binding
IAG43_RS16100	COG0303	'Molybdopterin
IAG43_RS16105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IAG43_RS16110	COG0604	alcohol dehydrogenase
IAG43_RS16125	COG1136	(ABC) transporter
IAG43_RS16125	COG4591	ABC-type transport system involved in lipoprotein release permease component
IAG43_RS16140	COG0515	serine threonine protein kinase
IAG43_RS16145	COG0515	serine threonine protein kinase
IAG43_RS16170	COG0022	dehydrogenase e1 component
IAG43_RS16175	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAG43_RS16185	COG2271	Major facilitator Superfamily
IAG43_RS16215	COG1136	(ABC) transporter
IAG43_RS16230	COG1362	aminopeptidase activity
IAG43_RS16235	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS16245	COG1741	Belongs to the pirin family
IAG43_RS16255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IAG43_RS16265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG43_RS16270	COG2304	oxidoreductase activity
IAG43_RS16290	COG1289	transmembrane transporter activity
IAG43_RS16350	COG1902	pentaerythritol trinitrate reductase activity
IAG43_RS16350	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAG43_RS16375	COG1937	Protein conserved in bacteria
IAG43_RS16380	COG0730	response to heat
IAG43_RS16400	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAG43_RS16445	COG0326	Molecular chaperone. Has ATPase activity
IAG43_RS16455	COG0717	Belongs to the dCTP deaminase family
IAG43_RS16475	COG2181	nitrate reductase activity
IAG43_RS16475	COG0247	lactate metabolic process
IAG43_RS16480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAG43_RS16485	COG0443	Heat shock 70 kDa protein
IAG43_RS16490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IAG43_RS16495	COG0484	heat shock protein binding
IAG43_RS16500	COG0789	Transcriptional regulator
IAG43_RS16525	COG0542	response to heat
IAG43_RS16545	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IAG43_RS16560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IAG43_RS16565	COG0191	fructose-bisphosphate aldolase activity
IAG43_RS16570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IAG43_RS16575	COG0477	Major facilitator Superfamily
IAG43_RS16590	COG3844	kynureninase activity
IAG43_RS16600	COG0702	epimerase
IAG43_RS16605	COG4585	Histidine kinase
IAG43_RS16610	COG2197	response regulator
IAG43_RS16630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IAG43_RS16655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IAG43_RS16680	COG0693	protein deglycase activity
IAG43_RS16685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG43_RS16705	COG1802	Transcriptional regulator
IAG43_RS16710	COG0463	Glycosyl transferase, family 2
IAG43_RS16725	COG2755	lipolytic protein G-D-S-L family
IAG43_RS16735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IAG43_RS16740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IAG43_RS16760	COG1595	DNA-templated transcription, initiation
IAG43_RS16790	COG2255	four-way junction helicase activity
IAG43_RS16865	COG1408	metallophosphoesterase
IAG43_RS16870	COG5650	phosphatidylinositol metabolic process
IAG43_RS16880	COG1610	YqeY-like protein
IAG43_RS16885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IAG43_RS16895	COG0003	Pfam Anion-transporting ATPase
IAG43_RS16920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG43_RS16945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG43_RS16950	COG2267	carboxylic ester hydrolase activity
IAG43_RS16960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IAG43_RS16965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG43_RS17030	COG1111	helicase
IAG43_RS17030	COG1205	dead DEAH box helicase
IAG43_RS17035	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS17040	COG2172	sigma factor antagonist activity
IAG43_RS17045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IAG43_RS17065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IAG43_RS17065	COG1754	DNA topoisomerase type I activity
IAG43_RS17070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IAG43_RS17075	COG0470	DNA polymerase III
IAG43_RS17160	COG2188	Transcriptional regulator
IAG43_RS17165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IAG43_RS17185	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS17205	COG2124	cytochrome p450
IAG43_RS17210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG43_RS17215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG43_RS17220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG43_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS17280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG43_RS17285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IAG43_RS17290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG43_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS17325	COG0477	Major facilitator Superfamily
IAG43_RS17350	COG2508	Transcriptional regulator
IAG43_RS17350	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IAG43_RS17355	COG0477	Major facilitator Superfamily
IAG43_RS17385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAG43_RS17385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAG43_RS17390	COG0110	maltose O-acetyltransferase activity
IAG43_RS17415	COG1136	(ABC) transporter
IAG43_RS17425	COG1556	Lactate utilization protein
IAG43_RS17430	COG1139	Iron-sulfur cluster binding protein
IAG43_RS17435	COG0247	lactate metabolic process
IAG43_RS17465	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS17470	COG2318	DinB family
IAG43_RS17485	COG0076	glutamate decarboxylase activity
IAG43_RS17490	COG0393	Putative heavy-metal-binding
IAG43_RS17495	COG0586	Pfam SNARE associated Golgi protein
IAG43_RS17505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IAG43_RS17510	COG2027	D-alanyl-D-alanine carboxypeptidase
IAG43_RS17520	COG0037	tRNA processing
IAG43_RS17535	COG0302	gtp cyclohydrolase
IAG43_RS17550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IAG43_RS17565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IAG43_RS17565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IAG43_RS17580	COG1174	glycine betaine transport
IAG43_RS17600	COG0649	NAD binding
IAG43_RS17615	COG2197	response regulator
IAG43_RS17620	COG1660	Displays ATPase and GTPase activities
IAG43_RS17635	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IAG43_RS17645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IAG43_RS17650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IAG43_RS17660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IAG43_RS17680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IAG43_RS17700	COG2027	D-alanyl-D-alanine carboxypeptidase
IAG43_RS17705	COG0739	heme binding
IAG43_RS17720	COG2205	protein histidine kinase activity
IAG43_RS17725	COG0745	RESPONSE REGULATOR receiver
IAG43_RS17735	COG1595	DNA-templated transcription, initiation
IAG43_RS17740	COG1194	a g-specific adenine glycosylase
IAG43_RS17745	COG0671	phosphoesterase, PA-phosphatase related
IAG43_RS17755	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IAG43_RS17775	COG0248	Ppx GppA phosphatase
IAG43_RS17780	COG1082	Xylose isomerase domain protein TIM barrel
IAG43_RS17790	COG0129	dihydroxy-acid dehydratase activity
IAG43_RS17795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG43_RS17795	COG0515	serine threonine protein kinase
IAG43_RS17800	COG4991	sh3 domain protein
IAG43_RS17810	COG2226	methyltransferase
IAG43_RS17815	COG1129	ABC transporter
IAG43_RS17815	COG0842	Transport permease protein
IAG43_RS17825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IAG43_RS17830	COG0180	Tryptophanyl-tRNA synthetase
IAG43_RS17850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG43_RS17855	COG2223	nitrite transmembrane transporter activity
IAG43_RS17860	COG0123	including yeast histone deacetylase and acetoin utilization protein
IAG43_RS17895	COG1595	DNA-templated transcription, initiation
IAG43_RS17910	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IAG43_RS17915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IAG43_RS17920	COG0181	hydroxymethylbilane synthase activity
IAG43_RS17925	COG1648	precorrin-2 dehydrogenase activity
IAG43_RS17925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAG43_RS17930	COG2226	methyltransferase
IAG43_RS17935	COG0113	porphobilinogen synthase activity
IAG43_RS17995	COG0018	arginyl-trna synthetase
IAG43_RS18000	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IAG43_RS18020	COG1690	Belongs to the RtcB family
IAG43_RS18040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAG43_RS18055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IAG43_RS18095	COG1309	transcriptional regulator
IAG43_RS18100	COG0596	Alpha beta hydrolase
IAG43_RS18115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAG43_RS18120	COG0406	alpha-ribazole phosphatase activity
IAG43_RS18135	COG0785	Cytochrome C biogenesis protein
IAG43_RS18140	COG1333	cytochrome c biogenesis protein
IAG43_RS18145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IAG43_RS18165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IAG43_RS18175	COG0109	protoheme IX farnesyltransferase activity
IAG43_RS18185	COG0163	prenyltransferase activity
IAG43_RS18200	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAG43_RS18215	COG1301	dicarboxylic acid transport
IAG43_RS18220	COG1309	transcriptional regulator
IAG43_RS18245	COG1278	Cold shock
IAG43_RS18250	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IAG43_RS18260	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAG43_RS18270	COG2226	methyltransferase
IAG43_RS18275	COG2066	Belongs to the glutaminase family
IAG43_RS18300	COG1388	LysM domain
IAG43_RS18300	COG3103	Sh3 type 3 domain protein
IAG43_RS18300	COG0791	NLP P60 protein
IAG43_RS18310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG43_RS18315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG43_RS18320	COG0649	NAD binding
IAG43_RS18330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IAG43_RS18335	COG1034	ATP synthesis coupled electron transport
IAG43_RS18340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IAG43_RS18345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG43_RS18350	COG0839	Belongs to the complex I subunit 6 family
IAG43_RS18355	COG0713	ATP synthesis coupled electron transport
IAG43_RS18360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAG43_RS18370	COG1007	ATP synthesis coupled electron transport
IAG43_RS18380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IAG43_RS18385	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IAG43_RS18390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAG43_RS18405	COG2188	Transcriptional regulator
IAG43_RS18415	COG3485	protocatechuate 3,4-dioxygenase
IAG43_RS18430	COG0142	geranyltranstransferase activity
IAG43_RS18440	COG2234	aminopeptidase activity
IAG43_RS18440	COG4935	Belongs to the peptidase S8 family
IAG43_RS18460	COG0702	epimerase
IAG43_RS18465	COG1733	regulation of RNA biosynthetic process
IAG43_RS18470	COG1013	pyruvate-flavodoxin oxidoreductase activity
IAG43_RS18475	COG0674	pyruvate-flavodoxin oxidoreductase activity
IAG43_RS18475	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IAG43_RS18495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG43_RS18500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG43_RS18505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG43_RS18510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IAG43_RS18515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG43_RS18525	COG0713	ATP synthesis coupled electron transport
IAG43_RS18530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAG43_RS18540	COG1007	ATP synthesis coupled electron transport
IAG43_RS18545	COG0501	Belongs to the peptidase M48B family
IAG43_RS18550	COG3304	Inner membrane component domain
IAG43_RS18560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAG43_RS18565	COG1666	GTP binding
IAG43_RS18580	COG0702	epimerase
IAG43_RS18600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAG43_RS18605	COG2030	dehydratase
IAG43_RS18620	COG0477	Major facilitator Superfamily
IAG43_RS18625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IAG43_RS18630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG43_RS18635	COG0436	Aminotransferase
IAG43_RS18645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAG43_RS18655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IAG43_RS18660	COG0081	regulation of translation
IAG43_RS18670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IAG43_RS18675	COG0222	ribosome binding
IAG43_RS18680	COG0085	RNA polymerase activity
IAG43_RS18685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IAG43_RS18690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IAG43_RS18695	COG0049	tRNA binding
IAG43_RS18700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IAG43_RS18705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAG43_RS18740	COG0051	transcription antitermination factor activity, RNA binding
IAG43_RS18745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IAG43_RS18750	COG0088	Forms part of the polypeptide exit tunnel
IAG43_RS18755	COG0089	rRNA binding
IAG43_RS18760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IAG43_RS18765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IAG43_RS18770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IAG43_RS18775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IAG43_RS18780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IAG43_RS18785	COG0255	Belongs to the universal ribosomal protein uL29 family
IAG43_RS18790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IAG43_RS18795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IAG43_RS18800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IAG43_RS18805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IAG43_RS18810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAG43_RS18815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IAG43_RS18820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IAG43_RS18825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IAG43_RS18830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IAG43_RS18835	COG1841	ribosomal large subunit assembly
IAG43_RS18840	COG0200	Binds to the 23S rRNA
IAG43_RS18850	COG0563	adenylate kinase activity
IAG43_RS18860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IAG43_RS18865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IAG43_RS18870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IAG43_RS18875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IAG43_RS18880	COG0202	RNA polymerase activity
IAG43_RS18885	COG0203	ribosomal protein L17
IAG43_RS18890	COG0101	tRNA pseudouridine synthase activity
IAG43_RS18905	COG0488	(ABC) transporter
IAG43_RS18910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IAG43_RS18915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAG43_RS18920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAG43_RS18930	COG1072	(Pantothenic acid kinase))
IAG43_RS18945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAG43_RS18950	COG0736	holo-[acyl-carrier-protein] synthase activity
IAG43_RS18960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAG43_RS18970	COG0802	atpase or kinase
IAG43_RS18995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IAG43_RS19010	COG4941	Belongs to the sigma-70 factor family
IAG43_RS19025	COG0726	polysaccharide deacetylase
IAG43_RS19045	COG4221	oxidoreductase activity
IAG43_RS19055	COG0583	DNA-binding transcription factor activity
IAG43_RS19065	COG2197	response regulator
IAG43_RS19070	COG1595	DNA-templated transcription, initiation
IAG43_RS19080	COG0516	GMP reductase activity
IAG43_RS19085	COG2826	transposase and inactivated derivatives, IS30 family
IAG43_RS19100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAG43_RS19115	COG0515	serine threonine protein kinase
IAG43_RS19120	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS19135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IAG43_RS19135	COG0519	Catalyzes the synthesis of GMP from XMP
IAG43_RS19155	COG2197	response regulator
IAG43_RS19190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG43_RS19210	COG0714	Associated with various cellular activities
IAG43_RS19220	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IAG43_RS19225	COG0045	succinate-CoA ligase (ADP-forming) activity
IAG43_RS19255	COG0138	bifunctional purine biosynthesis protein purh
IAG43_RS19260	COG0515	serine threonine protein kinase
IAG43_RS19260	COG2815	serine threonine protein kinase
IAG43_RS19275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IAG43_RS19285	COG0039	L-malate dehydrogenase activity
IAG43_RS19305	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS19315	COG4175	Glycine betaine
IAG43_RS19315	COG0517	IMP dehydrogenase activity
IAG43_RS19320	COG4176	ABC-type proline glycine betaine transport system permease component
IAG43_RS19370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG43_RS19375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG43_RS19405	COG0754	glutathionylspermidine amidase activity
IAG43_RS19410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG43_RS19415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAG43_RS19420	COG0180	Tryptophanyl-tRNA synthetase
IAG43_RS19430	COG1295	ribonuclease BN
IAG43_RS19435	COG1686	Belongs to the peptidase S11 family
IAG43_RS19440	COG1408	metallophosphoesterase
IAG43_RS19460	COG2267	carboxylic ester hydrolase activity
IAG43_RS19470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IAG43_RS19475	COG1053	succinate dehydrogenase
IAG43_RS19485	COG2009	succinate dehydrogenase
IAG43_RS19515	COG1247	-acetyltransferase
IAG43_RS19520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAG43_RS19525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAG43_RS19530	COG0640	Transcriptional regulator
IAG43_RS19545	COG0681	Belongs to the peptidase S26 family
IAG43_RS19625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IAG43_RS19630	COG1595	DNA-templated transcription, initiation
IAG43_RS19645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG43_RS19645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG43_RS19660	COG1216	Glycosyl transferase, family 2
IAG43_RS19675	COG2089	acid synthase
IAG43_RS19685	COG1473	amidohydrolase
IAG43_RS19685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IAG43_RS19690	COG1744	ABC transporter substrate-binding protein PnrA-like
IAG43_RS19695	COG3845	ABC transporter
IAG43_RS19705	COG1079	Belongs to the binding-protein-dependent transport system permease family
IAG43_RS19735	COG2814	Major facilitator Superfamily
IAG43_RS19740	COG0583	DNA-binding transcription factor activity
IAG43_RS19750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG43_RS19785	COG0745	RESPONSE REGULATOR receiver
IAG43_RS19790	COG1595	DNA-templated transcription, initiation
IAG43_RS19810	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS19815	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS19820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IAG43_RS19830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAG43_RS19860	COG4770	biotin carboxylase activity
IAG43_RS19870	COG0424	maF-like protein
IAG43_RS19890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG43_RS19905	COG1024	Enoyl-CoA hydratase
IAG43_RS19915	COG2986	histidine ammonia-lyase
IAG43_RS19930	COG1376	ErfK ybiS ycfS ynhG family protein
IAG43_RS19985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAG43_RS20020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IAG43_RS20035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IAG43_RS20045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG43_RS20085	COG1331	Highly conserved protein containing a thioredoxin domain
IAG43_RS20100	COG0463	Glycosyl transferase, family 2
IAG43_RS20120	COG1309	transcriptional regulator
IAG43_RS20130	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IAG43_RS20140	COG0436	Aminotransferase
IAG43_RS20145	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG43_RS20185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAG43_RS20195	COG0728	peptidoglycan biosynthetic process
IAG43_RS20275	COG2318	DinB family
IAG43_RS20285	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IAG43_RS20300	COG1414	Transcriptional regulator
IAG43_RS20305	COG0251	oxidation-reduction process
IAG43_RS20310	COG2610	gluconate transmembrane transporter activity
IAG43_RS20360	COG2894	cell division
IAG43_RS20395	COG2197	response regulator
IAG43_RS20415	COG2885	chlorophyll binding
IAG43_RS20440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IAG43_RS20450	COG0667	Aldo Keto reductase
IAG43_RS20455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAG43_RS20460	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG43_RS20460	COG0515	serine threonine protein kinase
IAG43_RS20465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IAG43_RS20485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG43_RS20490	COG0450	alkyl hydroperoxide reductase
IAG43_RS20505	COG1136	(ABC) transporter
IAG43_RS20525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAG43_RS20525	COG4499	WXG100 protein secretion system (Wss), protein YukC
IAG43_RS20545	COG0114	fumarate hydratase activity
IAG43_RS20550	COG2755	lipolytic protein G-D-S-L family
IAG43_RS20560	COG3209	COG3209 Rhs family protein
IAG43_RS20565	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IAG43_RS20565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IAG43_RS20595	COG0778	Nitroreductase
IAG43_RS20600	COG1722	exodeoxyribonuclease VII activity
IAG43_RS20605	COG1570	exodeoxyribonuclease VII activity
IAG43_RS20610	COG0531	amino acid
IAG43_RS20615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IAG43_RS20630	COG0012	GTP binding
IAG43_RS20665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IAG43_RS20675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IAG43_RS20685	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IAG43_RS20725	COG4607	ABC-type enterochelin transport system periplasmic component
IAG43_RS20730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS20735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS20740	COG1120	ATPase activity
IAG43_RS20755	COG1132	(ABC) transporter
IAG43_RS20765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IAG43_RS20770	COG3547	Transposase (IS116 IS110 IS902 family)
IAG43_RS20815	COG1842	Phage shock protein A
IAG43_RS20830	COG1053	succinate dehydrogenase
IAG43_RS20850	COG1217	gtp-binding protein TYPA
IAG43_RS20855	COG4166	transmembrane transport
IAG43_RS20860	COG0601	transmembrane transport
IAG43_RS20865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG43_RS20875	COG4608	Belongs to the ABC transporter superfamily
IAG43_RS20890	COG0601	transmembrane transport
IAG43_RS20895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG43_RS20900	COG0444	Belongs to the ABC transporter superfamily
IAG43_RS20925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG43_RS20970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG43_RS20975	COG1611	Belongs to the LOG family
IAG43_RS20980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IAG43_RS20990	COG0519	Catalyzes the synthesis of GMP from XMP
IAG43_RS20995	COG1024	Enoyl-CoA hydratase
IAG43_RS21010	COG1595	DNA-templated transcription, initiation
IAG43_RS21020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG43_RS21025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAG43_RS21060	COG0598	Magnesium transport protein CorA
IAG43_RS21075	COG0477	Major facilitator Superfamily
IAG43_RS21080	COG2814	Major facilitator Superfamily
IAG43_RS21095	COG2095	MarC family integral membrane protein
IAG43_RS21105	COG1432	Conserved Protein
IAG43_RS21115	COG0513	Belongs to the DEAD box helicase family
IAG43_RS21170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IAG43_RS21205	COG0210	DNA helicase
IAG43_RS21210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG43_RS21250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IAG43_RS21305	COG3480	Lon protease (S16) C-terminal proteolytic domain
IAG43_RS21315	COG1615	UPF0182 protein
IAG43_RS21340	COG0753	catalase activity
IAG43_RS21350	COG0483	inositol monophosphate 1-phosphatase activity
IAG43_RS21365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IAG43_RS21375	COG2135	peptidase activity
IAG43_RS21385	COG1595	DNA-templated transcription, initiation
IAG43_RS21390	COG5662	AntiSigma factor
IAG43_RS21400	COG0242	peptide deformylase activity
IAG43_RS21435	COG2188	Transcriptional regulator
IAG43_RS21440	COG2182	Extracellular solute-binding protein
IAG43_RS21445	COG1175	transmembrane transport
IAG43_RS21450	COG0395	ABC-type sugar transport system, permease component
IAG43_RS21455	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG43_RS21460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAG43_RS21475	COG1597	lipid kinase activity
IAG43_RS21510	COG0142	geranyltranstransferase activity
IAG43_RS21520	COG5640	endopeptidase activity
IAG43_RS21545	COG4106	trans-aconitate 2-methyltransferase activity
IAG43_RS21550	COG1126	abc transporter atp-binding protein
IAG43_RS21555	COG0765	amino acid transport
IAG43_RS21570	COG0604	alcohol dehydrogenase
IAG43_RS21595	COG0567	Dehydrogenase, E1 component
IAG43_RS21595	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAG43_RS21600	COG2205	protein histidine kinase activity
IAG43_RS21605	COG0745	RESPONSE REGULATOR receiver
IAG43_RS21625	COG1131	(ABC) transporter
IAG43_RS21635	COG1595	DNA-templated transcription, initiation
IAG43_RS21645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IAG43_RS21650	COG1357	PFAM Pentapeptide repeats (8 copies)
IAG43_RS21670	COG2205	protein histidine kinase activity
IAG43_RS21730	COG0768	penicillin binding
IAG43_RS21760	COG3285	dna ligase
IAG43_RS21760	COG1793	dna ligase
IAG43_RS21765	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IAG43_RS21775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG43_RS21815	COG0745	RESPONSE REGULATOR receiver
IAG43_RS21820	COG0018	arginyl-trna synthetase
IAG43_RS21825	COG0019	diaminopimelate decarboxylase activity
IAG43_RS21830	COG0460	homoserine dehydrogenase
IAG43_RS21835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IAG43_RS21840	COG0083	homoserine kinase activity
IAG43_RS21850	COG1316	TRANSCRIPTIONal
IAG43_RS21855	COG0254	rRNA binding
IAG43_RS21860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IAG43_RS21865	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG43_RS21875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAG43_RS21880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAG43_RS21900	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAG43_RS21905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IAG43_RS21910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAG43_RS21915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IAG43_RS21920	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IAG43_RS21925	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IAG43_RS21930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IAG43_RS21945	COG2197	response regulator
IAG43_RS21950	COG4585	Histidine kinase
IAG43_RS21965	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG43_RS21980	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IAG43_RS22035	COG0183	Belongs to the thiolase family
IAG43_RS22050	COG0745	RESPONSE REGULATOR receiver
IAG43_RS22055	COG2205	protein histidine kinase activity
IAG43_RS22060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAG43_RS22115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG43_RS22115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG43_RS22150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IAG43_RS22155	COG0280	phosphate acetyltransferase
IAG43_RS22155	COG0857	belongs to the CobB CobQ family
IAG43_RS22160	COG0205	6-phosphofructokinase activity
IAG43_RS22170	COG4565	transcriptional regulatory protein
IAG43_RS22175	COG3290	protein histidine kinase activity
IAG43_RS22180	COG1301	dicarboxylic acid transport
IAG43_RS22195	COG0789	Transcriptional regulator
IAG43_RS22200	COG3118	belongs to the thioredoxin family
IAG43_RS22215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IAG43_RS22220	COG3281	Trehalose synthase
IAG43_RS22225	COG0366	Alpha amylase catalytic
IAG43_RS22230	COG0366	Alpha amylase catalytic
IAG43_RS22235	COG0058	SHG alpha-glucan phosphorylase activity
IAG43_RS22285	COG2252	PERMEase
IAG43_RS22290	COG4585	Histidine kinase
IAG43_RS22310	COG1132	(ABC) transporter
IAG43_RS22315	COG1132	(ABC) transporter
IAG43_RS22330	COG4585	Histidine kinase
IAG43_RS22335	COG2197	response regulator
IAG43_RS22345	COG1695	Transcriptional regulator
IAG43_RS22360	COG1376	ErfK ybiS ycfS ynhG family protein
IAG43_RS22365	COG1376	ErfK ybiS ycfS ynhG family protein
IAG43_RS22370	COG1024	Enoyl-CoA hydratase
IAG43_RS22410	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IAG43_RS22440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAG43_RS22445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG43_RS22460	COG1760	l-serine dehydratase
IAG43_RS22465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAG43_RS22470	COG0509	glycine decarboxylation via glycine cleavage system
IAG43_RS22475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAG43_RS22495	COG0747	negative chemotaxis
IAG43_RS22500	COG0601	transmembrane transport
IAG43_RS22505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG43_RS22510	COG0444	Belongs to the ABC transporter superfamily
IAG43_RS22515	COG4608	Belongs to the ABC transporter superfamily
IAG43_RS22520	COG2860	membrane
IAG43_RS22560	COG0789	Transcriptional regulator
IAG43_RS22570	COG1192	Involved in chromosome partitioning
IAG43_RS22605	COG0482	sulfurtransferase activity
IAG43_RS22610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IAG43_RS22615	COG3119	arylsulfatase activity
IAG43_RS22630	COG4221	oxidoreductase activity
IAG43_RS22640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAG43_RS22650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAG43_RS22655	COG0154	amidase activity
IAG43_RS22665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAG43_RS22685	COG2409	Drug exporters of the RND superfamily
IAG43_RS22690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG43_RS22700	COG2197	response regulator
IAG43_RS22705	COG2133	pyrroloquinoline quinone binding
IAG43_RS22710	COG0667	Aldo Keto reductase
IAG43_RS22730	COG0440	acetolactate synthase activity
IAG43_RS22735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IAG43_RS22745	COG0477	Major facilitator Superfamily
IAG43_RS22760	COG0506	proline dehydrogenase activity
IAG43_RS22765	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS22780	COG0473	3-isopropylmalate dehydrogenase activity
IAG43_RS22785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAG43_RS22790	COG0832	Belongs to the urease beta subunit family
IAG43_RS22790	COG0831	urea catabolic process
IAG43_RS22795	COG0804	urea catabolic process
IAG43_RS22800	COG2957	Belongs to the agmatine deiminase family
IAG43_RS22810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAG43_RS22820	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG43_RS22835	COG2353	YceI-like domain
IAG43_RS22855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG43_RS22875	COG2018	Roadblock/LC7 domain
IAG43_RS22895	COG2018	Roadblock/LC7 domain
IAG43_RS22900	COG5002	protein histidine kinase activity
IAG43_RS22910	COG0179	Fumarylacetoacetate (FAA) hydrolase
IAG43_RS22915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IAG43_RS22925	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IAG43_RS22960	COG1414	Transcriptional regulator
IAG43_RS22965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IAG43_RS22970	COG0066	3-isopropylmalate dehydratase activity
IAG43_RS22980	COG0776	regulation of translation
IAG43_RS22990	COG1920	GTP binding
IAG43_RS23000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IAG43_RS23005	COG1181	Belongs to the D-alanine--D-alanine ligase family
IAG43_RS23025	COG0351	phosphomethylpyrimidine kinase
IAG43_RS23030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IAG43_RS23035	COG1461	Dihydroxyacetone kinase
IAG43_RS23045	COG0742	ribosomal rna small subunit methyltransferase
IAG43_RS23050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IAG43_RS23065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IAG43_RS23070	COG0571	ribonuclease III activity
IAG43_RS23075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAG43_RS23085	COG2340	Cysteine-rich secretory protein family
IAG43_RS23090	COG1254	Belongs to the acylphosphatase family
IAG43_RS23105	COG0477	Major facilitator Superfamily
IAG43_RS23135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IAG43_RS23155	COG0228	four-way junction DNA binding
IAG43_RS23160	COG1837	Belongs to the UPF0109 family
IAG43_RS23165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IAG43_RS23170	COG0336	Belongs to the RNA methyltransferase TrmD family
IAG43_RS23175	COG0335	large ribosomal subunit rRNA binding
IAG43_RS23180	COG0681	Belongs to the peptidase S26 family
IAG43_RS23190	COG0681	Belongs to the peptidase S26 family
IAG43_RS23195	COG0681	Belongs to the peptidase S26 family
IAG43_RS23210	COG0792	nuclease activity
IAG43_RS23225	COG1191	sigma factor activity
IAG43_RS23240	COG0052	Belongs to the universal ribosomal protein uS2 family
IAG43_RS23245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IAG43_RS23250	COG0528	UMP kinase activity
IAG43_RS23255	COG0233	cytoplasmic translational termination
IAG43_RS23260	COG0575	Belongs to the CDS family
IAG43_RS23265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IAG43_RS23275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IAG43_RS23280	COG3842	ATPase activity
IAG43_RS23290	COG1136	(ABC) transporter
IAG43_RS23295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAG43_RS23305	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS23315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG43_RS23320	COG2197	response regulator
IAG43_RS23325	COG4585	Histidine kinase
IAG43_RS23340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG43_RS23360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IAG43_RS23365	COG3842	ATPase activity
IAG43_RS23370	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAG43_RS23375	COG1177	transmembrane transport
IAG43_RS23380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAG43_RS23410	COG2508	Transcriptional regulator
IAG43_RS23415	COG2124	cytochrome p450
IAG43_RS23420	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS23430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IAG43_RS23440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IAG43_RS23445	COG0750	zinc metalloprotease
IAG43_RS23450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IAG43_RS23465	COG0442	prolyl-tRNA aminoacylation
IAG43_RS23470	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
IAG43_RS23485	COG0779	Required for maturation of 30S ribosomal subunits
IAG43_RS23500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IAG43_RS23510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IAG43_RS23515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IAG43_RS23535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG43_RS23540	COG0601	transmembrane transport
IAG43_RS23550	COG0455	bacterial-type flagellum organization
IAG43_RS23570	COG3266	domain, Protein
IAG43_RS23575	COG1404	Belongs to the peptidase S8 family
IAG43_RS23590	COG1404	Belongs to the peptidase S8 family
IAG43_RS23625	COG1674	ftsk spoiiie
IAG43_RS23635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IAG43_RS23640	COG1185	polyribonucleotide nucleotidyltransferase activity
IAG43_RS23645	COG0612	Peptidase, M16
IAG43_RS23650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IAG43_RS23670	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IAG43_RS23675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG43_RS23680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IAG43_RS23705	COG2208	phosphoserine phosphatase activity
IAG43_RS23705	COG2770	Histidine kinase
IAG43_RS23710	COG0784	Response regulator, receiver
IAG43_RS23710	COG2205	protein histidine kinase activity
IAG43_RS23720	COG1674	ftsk spoiiie
IAG43_RS23730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAG43_RS23740	COG1546	Belongs to the CinA family
IAG43_RS23740	COG1058	Belongs to the CinA family
IAG43_RS23745	COG1396	sequence-specific DNA binding
IAG43_RS23750	COG0783	Belongs to the Dps family
IAG43_RS23760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAG43_RS23765	COG1201	RNA secondary structure unwinding
IAG43_RS23770	COG1917	Cupin 2, conserved barrel domain protein
IAG43_RS23770	COG2207	Transcriptional regulator
IAG43_RS23800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IAG43_RS23820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAG43_RS23825	COG0765	amino acid transport
IAG43_RS23830	COG0765	amino acid transport
IAG43_RS23835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG43_RS23840	COG1126	abc transporter atp-binding protein
IAG43_RS23850	COG2205	protein histidine kinase activity
IAG43_RS23860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAG43_RS23880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IAG43_RS23890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IAG43_RS23895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAG43_RS23905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IAG43_RS23945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IAG43_RS23950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IAG43_RS23955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAG43_RS23975	COG0588	phosphoglycerate mutase activity
IAG43_RS23995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAG43_RS24030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IAG43_RS24035	COG1802	Transcriptional regulator
IAG43_RS24040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAG43_RS24055	COG0187	DNA topoisomerase II activity
IAG43_RS24065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG43_RS24070	COG4565	transcriptional regulatory protein
IAG43_RS24075	COG3290	protein histidine kinase activity
IAG43_RS24085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAG43_RS24090	COG0612	Peptidase, M16
IAG43_RS24105	COG1802	Transcriptional regulator
IAG43_RS24110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAG43_RS24115	COG0045	succinate-CoA ligase (ADP-forming) activity
IAG43_RS24115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAG43_RS24115	COG1042	CoA-binding domain protein
IAG43_RS24130	COG1435	thymidine kinase activity
IAG43_RS24165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IAG43_RS24180	COG0745	RESPONSE REGULATOR receiver
IAG43_RS24185	COG2205	protein histidine kinase activity
IAG43_RS24210	COG0756	dUTP diphosphatase activity
IAG43_RS24220	COG1136	(ABC) transporter
IAG43_RS24220	COG4591	ABC-type transport system involved in lipoprotein release permease component
IAG43_RS24250	COG0569	domain protein
IAG43_RS24255	COG0531	amino acid
IAG43_RS24260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IAG43_RS24300	COG5002	protein histidine kinase activity
IAG43_RS24335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAG43_RS24340	COG0183	Belongs to the thiolase family
IAG43_RS24350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IAG43_RS24355	COG1309	transcriptional regulator
IAG43_RS24380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG43_RS24395	COG0583	DNA-binding transcription factor activity
IAG43_RS24400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IAG43_RS24405	COG0402	S-adenosylhomocysteine deaminase activity
IAG43_RS24440	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IAG43_RS24455	COG1105	Belongs to the carbohydrate kinase PfkB family
IAG43_RS24465	COG0483	inositol monophosphate 1-phosphatase activity
IAG43_RS24510	COG3845	ABC transporter
IAG43_RS24570	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IAG43_RS24570	COG1672	PFAM Archaeal ATPase
IAG43_RS24580	COG1404	Belongs to the peptidase S8 family
IAG43_RS24580	COG4412	M6 family metalloprotease domain protein
IAG43_RS24585	COG4124	Belongs to the glycosyl hydrolase 26 family
IAG43_RS24590	COG2301	Belongs to the HpcH HpaI aldolase family
IAG43_RS24595	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IAG43_RS24600	COG0477	Major facilitator Superfamily
IAG43_RS24605	COG2267	carboxylic ester hydrolase activity
IAG43_RS24610	COG0583	DNA-binding transcription factor activity
IAG43_RS24615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG43_RS24670	COG3507	Belongs to the glycosyl hydrolase 43 family
IAG43_RS24675	COG1609	Transcriptional regulator
IAG43_RS24685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS24690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IAG43_RS24720	COG0604	alcohol dehydrogenase
IAG43_RS24720	COG3321	synthase
IAG43_RS24725	COG0604	alcohol dehydrogenase
IAG43_RS24725	COG3321	synthase
IAG43_RS24730	COG0604	alcohol dehydrogenase
IAG43_RS24730	COG3321	synthase
IAG43_RS24795	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS24800	COG0500	methyltransferase
IAG43_RS24815	COG1253	flavin adenine dinucleotide binding
IAG43_RS24835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAG43_RS24875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAG43_RS24890	COG1487	ribonuclease activity
IAG43_RS24915	COG1175	transmembrane transport
IAG43_RS24920	COG0395	ABC-type sugar transport system, permease component
IAG43_RS24925	COG0366	Alpha amylase catalytic
IAG43_RS25015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IAG43_RS25035	COG1132	(ABC) transporter
IAG43_RS25040	COG3833	ABC-type maltose transport systems, permease component
IAG43_RS25045	COG1175	transmembrane transport
IAG43_RS25055	COG3250	beta-galactosidase activity
IAG43_RS25060	COG1609	Transcriptional regulator
IAG43_RS25085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IAG43_RS25095	COG0181	hydroxymethylbilane synthase activity
IAG43_RS25120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG43_RS25125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG43_RS25150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IAG43_RS25155	COG0366	Alpha amylase catalytic
IAG43_RS25155	COG1874	Beta-galactosidase
IAG43_RS25175	COG5297	Belongs to the glycosyl hydrolase family 6
IAG43_RS25175	COG2273	Hydrolase Family 16
IAG43_RS25190	COG1175	transmembrane transport
IAG43_RS25195	COG0395	ABC-type sugar transport system, permease component
IAG43_RS25210	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IAG43_RS25215	COG0714	Associated with various cellular activities
IAG43_RS25225	COG1609	Transcriptional regulator
IAG43_RS25230	COG2182	Extracellular solute-binding protein
IAG43_RS25235	COG1175	transmembrane transport
IAG43_RS25245	COG0366	Alpha amylase catalytic
IAG43_RS25265	COG1799	cell septum assembly
IAG43_RS25295	COG2040	homocysteine
IAG43_RS25305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IAG43_RS25315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IAG43_RS25325	COG1024	Enoyl-CoA hydratase
IAG43_RS25345	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS25395	COG1733	regulation of RNA biosynthetic process
IAG43_RS25450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG43_RS25465	COG1605	Chorismate mutase
IAG43_RS25470	COG1280	lysine exporter protein (LysE YggA)
IAG43_RS25500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAG43_RS25520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG43_RS25520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG43_RS25550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG43_RS25560	COG3629	intracellular signal transduction
IAG43_RS25610	COG2271	Major facilitator Superfamily
IAG43_RS25620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAG43_RS25625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IAG43_RS25630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG43_RS25635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG43_RS25640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAG43_RS25665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG43_RS25705	COG1597	lipid kinase activity
IAG43_RS25725	COG0477	Major facilitator Superfamily
IAG43_RS25770	COG1309	transcriptional regulator
IAG43_RS25810	COG1621	beta-fructofuranosidase activity
IAG43_RS25815	COG0395	ABC-type sugar transport system, permease component
IAG43_RS25820	COG1175	transmembrane transport
IAG43_RS25825	COG1653	transport
IAG43_RS25830	COG1609	Transcriptional regulator
IAG43_RS25835	COG1621	beta-fructofuranosidase activity
IAG43_RS25840	COG1621	beta-fructofuranosidase activity
IAG43_RS25845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAG43_RS25855	COG0477	Major facilitator Superfamily
IAG43_RS25860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IAG43_RS25890	COG1653	transport
IAG43_RS25895	COG1175	transmembrane transport
IAG43_RS25900	COG0395	ABC-type sugar transport system, permease component
IAG43_RS25905	COG1940	carbohydrate kinase activity
IAG43_RS25910	COG4213	ABC transporter substrate-binding protein
IAG43_RS25920	COG4214	carbohydrate transport
IAG43_RS25925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAG43_RS25930	COG0531	amino acid
IAG43_RS25945	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG43_RS25945	COG1024	Enoyl-CoA hydratase
IAG43_RS25950	COG0183	Belongs to the thiolase family
IAG43_RS25975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IAG43_RS25980	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAG43_RS25990	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IAG43_RS25995	COG3253	May function as heme-dependent peroxidase
IAG43_RS26005	COG3220	belongs to the UPF0276 family
IAG43_RS26060	COG1846	Transcriptional regulator
IAG43_RS26065	COG1764	response to oxidative stress
IAG43_RS26070	COG2326	polyphosphate kinase activity
IAG43_RS26100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IAG43_RS26105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAG43_RS26115	COG2197	response regulator
IAG43_RS26120	COG4585	Histidine kinase
IAG43_RS26125	COG1131	(ABC) transporter
IAG43_RS26140	COG0346	lactoylglutathione lyase activity
IAG43_RS26215	COG1175	transmembrane transport
IAG43_RS26255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAG43_RS26260	COG1116	anion transmembrane transporter activity
IAG43_RS26280	COG0529	Catalyzes the synthesis of activated sulfate
IAG43_RS26280	COG2046	Belongs to the sulfate adenylyltransferase family
IAG43_RS26285	COG0175	sulfate reduction
IAG43_RS26310	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS26355	COG1796	DNA polymerase
IAG43_RS26355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IAG43_RS26360	COG1162	GTPase activity
IAG43_RS26385	COG0028	Belongs to the TPP enzyme family
IAG43_RS26405	COG1802	Transcriptional regulator
IAG43_RS26430	COG3835	regulator
IAG43_RS26445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG43_RS26450	COG2252	PERMEase
IAG43_RS26455	COG3608	succinylglutamate desuccinylase aspartoacylase
IAG43_RS26455	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IAG43_RS26465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAG43_RS26475	COG2197	response regulator
IAG43_RS26480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG43_RS26485	COG0318	PFAM AMP-dependent synthetase and ligase
IAG43_RS26500	COG3960	tartronate-semialdehyde synthase activity
IAG43_RS26510	COG0753	catalase activity
IAG43_RS26515	COG2084	Dehydrogenase
IAG43_RS26520	COG3622	Belongs to the hyi family
IAG43_RS26525	COG1289	transmembrane transporter activity
IAG43_RS26545	COG2351	hydroxyisourate hydrolase activity
IAG43_RS26555	COG2233	PERMEase
IAG43_RS26565	COG2233	PERMEase
IAG43_RS26615	COG0745	RESPONSE REGULATOR receiver
IAG43_RS26620	COG2205	protein histidine kinase activity
IAG43_RS26635	COG2340	Cysteine-rich secretory protein family
IAG43_RS26650	COG0515	serine threonine protein kinase
IAG43_RS26655	COG5297	Belongs to the glycosyl hydrolase family 6
IAG43_RS26655	COG4733	cellulase activity
IAG43_RS26690	COG2226	methyltransferase
IAG43_RS26695	COG1309	transcriptional regulator
IAG43_RS26705	COG0154	amidase activity
IAG43_RS26740	COG2356	endonuclease I
IAG43_RS26745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG43_RS26745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG43_RS26760	COG2985	domain, Protein
IAG43_RS26765	COG2985	domain, Protein
IAG43_RS26785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IAG43_RS26815	COG1414	Transcriptional regulator
IAG43_RS26820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAG43_RS26825	COG4266	Belongs to the allantoicase family
IAG43_RS26830	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS26855	COG2197	response regulator
IAG43_RS26870	COG0673	inositol 2-dehydrogenase activity
IAG43_RS26875	COG2188	Transcriptional regulator
IAG43_RS26895	COG1940	carbohydrate kinase activity
IAG43_RS26945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAG43_RS26960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG43_RS26965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAG43_RS26980	COG1126	abc transporter atp-binding protein
IAG43_RS26990	COG0405	Gamma-glutamyltransferase
IAG43_RS27050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG43_RS27055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAG43_RS27065	COG1953	Uracil, thiamine, allantoin
IAG43_RS27080	COG0477	Major facilitator Superfamily
IAG43_RS27130	COG0477	Major facilitator Superfamily
IAG43_RS27160	COG2124	cytochrome p450
IAG43_RS27165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IAG43_RS27170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAG43_RS27190	COG0405	Gamma-glutamyltransferase
IAG43_RS27195	COG0483	inositol monophosphate 1-phosphatase activity
IAG43_RS27210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IAG43_RS27225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAG43_RS27235	COG1929	Belongs to the glycerate kinase type-1 family
IAG43_RS27245	COG0688	phosphatidylethanolamine metabolic process
IAG43_RS27250	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS27265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG43_RS27265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG43_RS27270	COG0604	alcohol dehydrogenase
IAG43_RS27280	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG43_RS27320	COG1834	amidinotransferase
IAG43_RS27325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG43_RS27330	COG2362	D-Aminopeptidase
IAG43_RS27335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG43_RS27345	COG1619	proteins homologs of microcin C7 resistance protein MccF
IAG43_RS27350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAG43_RS27375	COG2226	methyltransferase
IAG43_RS27380	COG1819	glycosyl
IAG43_RS27400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IAG43_RS27440	COG1793	dna ligase
IAG43_RS27450	COG2154	pterin-4-alpha-carbinolamine dehydratase
IAG43_RS27465	COG0656	L-ascorbic acid biosynthetic process
IAG43_RS27490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IAG43_RS27495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAG43_RS27505	COG1940	carbohydrate kinase activity
IAG43_RS27510	COG1129	ABC transporter
IAG43_RS27515	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAG43_RS27520	COG1879	ABC-type sugar transport system periplasmic component
IAG43_RS27525	COG0673	inositol 2-dehydrogenase activity
IAG43_RS27545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IAG43_RS27560	COG0084	hydrolase, TatD family'
IAG43_RS27630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IAG43_RS27640	COG2188	Transcriptional regulator
IAG43_RS27645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAG43_RS27690	COG3321	synthase
IAG43_RS27690	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS27690	COG0604	alcohol dehydrogenase
IAG43_RS27695	COG3250	beta-galactosidase activity
IAG43_RS27715	COG0494	nUDIX hydrolase
IAG43_RS27720	COG3401	FG-GAP repeat protein
IAG43_RS27725	COG1120	ATPase activity
IAG43_RS27790	COG5635	Nacht domain
IAG43_RS27790	COG2319	Wd-40 repeat
IAG43_RS27795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAG43_RS27820	COG4106	trans-aconitate 2-methyltransferase activity
IAG43_RS27835	COG0019	diaminopimelate decarboxylase activity
IAG43_RS27845	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IAG43_RS27860	COG1132	(ABC) transporter
IAG43_RS27885	COG1070	Carbohydrate kinase
IAG43_RS27950	COG3903	Transcriptional regulator
IAG43_RS27950	COG3629	intracellular signal transduction
IAG43_RS27960	COG1486	melibiose metabolic process
IAG43_RS27965	COG3012	SEC-C Motif Domain Protein
IAG43_RS27970	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS28010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IAG43_RS28070	COG1793	dna ligase
IAG43_RS28150	COG1515	deoxyribonuclease V activity
IAG43_RS28175	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS28205	COG3268	Saccharopine dehydrogenase
IAG43_RS28210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG43_RS28215	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS28220	COG0183	Belongs to the thiolase family
IAG43_RS28225	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG43_RS28225	COG1024	Enoyl-CoA hydratase
IAG43_RS28235	COG0789	Transcriptional regulator
IAG43_RS28245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAG43_RS28280	COG0395	ABC-type sugar transport system, permease component
IAG43_RS28285	COG1175	transmembrane transport
IAG43_RS28305	COG3226	Transcriptional regulator
IAG43_RS28315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAG43_RS28320	COG0488	(ABC) transporter
IAG43_RS28330	COG2183	response to ionizing radiation
IAG43_RS28340	COG4977	sequence-specific DNA binding
IAG43_RS28350	COG1024	Enoyl-CoA hydratase
IAG43_RS28360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IAG43_RS28385	COG0371	Dehydrogenase
IAG43_RS28405	COG1388	LysM domain
IAG43_RS28405	COG1134	teichoic acid transport
IAG43_RS28410	COG1562	ergosterol biosynthetic process
IAG43_RS28420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IAG43_RS28430	COG1657	PFAM Prenyltransferase squalene oxidase
IAG43_RS28460	COG2365	Tyrosine phosphatase family
IAG43_RS28470	COG2755	lipolytic protein G-D-S-L family
IAG43_RS28495	COG0494	nUDIX hydrolase
IAG43_RS28500	COG3540	Alkaline phosphatase
IAG43_RS28530	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS28545	COG0789	Transcriptional regulator
IAG43_RS28555	COG3958	Transketolase
IAG43_RS28560	COG3959	Transketolase, thiamine diphosphate binding domain
IAG43_RS28570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IAG43_RS28575	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IAG43_RS28590	COG3511	phospholipase C
IAG43_RS28605	COG1349	DNA-binding transcription factor activity
IAG43_RS28625	COG3189	MarR family transcriptional regulator
IAG43_RS28645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAG43_RS28680	COG4733	cellulase activity
IAG43_RS28680	COG5297	Belongs to the glycosyl hydrolase family 6
IAG43_RS28685	COG5297	Belongs to the glycosyl hydrolase family 6
IAG43_RS28690	COG1609	Transcriptional regulator
IAG43_RS28695	COG1595	DNA-templated transcription, initiation
IAG43_RS28705	COG4677	pectinesterase activity
IAG43_RS28710	COG3866	Pectate lyase
IAG43_RS28715	COG2755	lipolytic protein G-D-S-L family
IAG43_RS28720	COG1653	transport
IAG43_RS28740	COG0395	ABC-type sugar transport system, permease component
IAG43_RS28760	COG1802	Transcriptional regulator
IAG43_RS28765	COG1501	Belongs to the glycosyl hydrolase 31 family
IAG43_RS28770	COG2755	lipolytic protein G-D-S-L family
IAG43_RS28775	COG0789	Transcriptional regulator
IAG43_RS28820	COG4209	transmembrane transport
IAG43_RS28825	COG0395	ABC-type sugar transport system, permease component
IAG43_RS28850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IAG43_RS28885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IAG43_RS28915	COG1121	(ABC) transporter
IAG43_RS28955	COG2226	methyltransferase
IAG43_RS28960	COG1794	racemase activity, acting on amino acids and derivatives
IAG43_RS28965	COG0784	Response regulator, receiver
IAG43_RS28980	COG3547	Transposase (IS116 IS110 IS902 family)
IAG43_RS29090	COG0464	growth
IAG43_RS29110	COG2080	2 iron, 2 sulfur cluster binding
IAG43_RS29115	COG2010	Cytochrome c
IAG43_RS29115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG43_RS29140	COG1309	transcriptional regulator
IAG43_RS29160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG43_RS29165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS29170	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS29175	COG0183	Belongs to the thiolase family
IAG43_RS29180	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG43_RS29180	COG1024	Enoyl-CoA hydratase
IAG43_RS29185	COG1022	Amp-dependent synthetase and ligase
IAG43_RS29210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAG43_RS29225	COG1215	transferase activity, transferring glycosyl groups
IAG43_RS29235	COG4310	Domain of unknown function (DUF2172)
IAG43_RS29250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAG43_RS29285	COG0367	asparagine synthase
IAG43_RS29305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAG43_RS29315	COG3618	amidohydrolase
IAG43_RS29330	COG4948	Mandelate Racemase Muconate Lactonizing
IAG43_RS29370	COG4166	transmembrane transport
IAG43_RS29375	COG2274	protein secretion by the type I secretion system
IAG43_RS29380	COG1132	(ABC) transporter
IAG43_RS29395	COG2366	antibiotic biosynthetic process
IAG43_RS29400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS29405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS29410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS29445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS29460	COG2022	thiamine diphosphate biosynthetic process
IAG43_RS29530	COG0582	viral genome integration into host DNA
IAG43_RS29570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IAG43_RS29585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IAG43_RS29590	COG0573	inorganic phosphate transmembrane transporter activity
IAG43_RS29615	COG2226	methyltransferase
IAG43_RS29620	COG0640	Transcriptional regulator
IAG43_RS29625	COG0492	ferredoxin-NADP+ reductase activity
IAG43_RS29630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAG43_RS29640	COG0798	PFAM Bile acid sodium symporter
IAG43_RS29645	COG2072	flavoprotein involved in K transport
IAG43_RS29655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAG43_RS29665	COG1181	Belongs to the D-alanine--D-alanine ligase family
IAG43_RS29670	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IAG43_RS29670	COG0235	Class ii aldolase
IAG43_RS29675	COG0235	Class ii aldolase
IAG43_RS29675	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IAG43_RS29680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IAG43_RS29685	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IAG43_RS29690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IAG43_RS29695	COG0456	acetyltransferase
IAG43_RS29705	COG0640	Transcriptional regulator
IAG43_RS29710	COG0640	Transcriptional regulator
IAG43_RS29715	COG1247	-acetyltransferase
IAG43_RS29720	COG0640	Transcriptional regulator
IAG43_RS29735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IAG43_RS29745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IAG43_RS29795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAG43_RS29820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG43_RS29825	COG3275	phosphorelay sensor kinase activity
IAG43_RS29850	COG0726	polysaccharide deacetylase
IAG43_RS29875	COG2267	carboxylic ester hydrolase activity
IAG43_RS29895	COG0583	DNA-binding transcription factor activity
IAG43_RS29905	COG1053	succinate dehydrogenase
IAG43_RS29910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IAG43_RS29920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG43_RS29940	COG1609	Transcriptional regulator
IAG43_RS29960	COG1879	ABC-type sugar transport system periplasmic component
IAG43_RS29965	COG3250	beta-galactosidase activity
IAG43_RS29980	COG1733	regulation of RNA biosynthetic process
IAG43_RS29990	COG0326	Molecular chaperone. Has ATPase activity
IAG43_RS30005	COG2826	transposase and inactivated derivatives, IS30 family
IAG43_RS30015	COG1131	(ABC) transporter
IAG43_RS30030	COG2261	transglycosylase associated protein
IAG43_RS30115	COG1846	Transcriptional regulator
IAG43_RS30140	COG3507	Belongs to the glycosyl hydrolase 43 family
IAG43_RS30145	COG3940	Belongs to the glycosyl hydrolase 43 family
IAG43_RS30150	COG0009	L-threonylcarbamoyladenylate synthase
IAG43_RS30155	COG3254	rhamnose metabolic process
IAG43_RS30160	COG1609	Transcriptional regulator
IAG43_RS30195	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS30210	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IAG43_RS30215	COG0346	lactoylglutathione lyase activity
IAG43_RS30220	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS30225	COG2814	Major facilitator Superfamily
IAG43_RS30260	COG1846	Transcriptional regulator
IAG43_RS30270	COG1653	transport
IAG43_RS30280	COG0673	inositol 2-dehydrogenase activity
IAG43_RS30290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAG43_RS30295	COG3540	Alkaline phosphatase
IAG43_RS30330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG43_RS30355	COG3458	cephalosporin-C deacetylase activity
IAG43_RS30385	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS30390	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS30400	COG0601	transmembrane transport
IAG43_RS30405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG43_RS30410	COG0444	Belongs to the ABC transporter superfamily
IAG43_RS30455	COG0488	(ABC) transporter
IAG43_RS30500	COG1960	acyl-CoA dehydrogenase activity
IAG43_RS30510	COG2409	Drug exporters of the RND superfamily
IAG43_RS30515	COG3046	protein related to deoxyribodipyrimidine photolyase
IAG43_RS30540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAG43_RS30540	COG1024	Enoyl-CoA hydratase
IAG43_RS30555	COG0667	Aldo Keto reductase
IAG43_RS30595	COG2211	Major facilitator Superfamily
IAG43_RS30640	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IAG43_RS30655	COG0277	FAD linked oxidase domain protein
IAG43_RS30665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAG43_RS30685	COG0488	(ABC) transporter
IAG43_RS30695	COG1191	sigma factor activity
IAG43_RS30710	COG3903	Transcriptional regulator
IAG43_RS30710	COG3629	intracellular signal transduction
IAG43_RS30740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS30745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS30745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS30765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG43_RS30785	COG0017	Asparaginyl-tRNA synthetase
IAG43_RS30790	COG0069	glutamate synthase activity
IAG43_RS30810	COG0513	Belongs to the DEAD box helicase family
IAG43_RS30825	COG0697	spore germination
IAG43_RS30850	COG0326	Molecular chaperone. Has ATPase activity
IAG43_RS30865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAG43_RS30880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IAG43_RS30885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IAG43_RS30890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS30895	COG1120	ATPase activity
IAG43_RS30905	COG1428	Deoxynucleoside kinase
IAG43_RS30915	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IAG43_RS30925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IAG43_RS30940	COG1120	ATPase activity
IAG43_RS30945	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS30950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS30955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IAG43_RS30965	COG1535	isochorismatase
IAG43_RS30965	COG3433	isochorismatase activity
IAG43_RS30970	COG1535	isochorismatase
IAG43_RS30970	COG3433	isochorismatase activity
IAG43_RS30975	COG1021	2,3-dihydroxybenzoate-AMP ligase
IAG43_RS30980	COG1169	isochorismate synthase
IAG43_RS30985	COG1028	Short-chain dehydrogenase reductase Sdr
IAG43_RS30995	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IAG43_RS31015	COG0142	geranyltranstransferase activity
IAG43_RS31020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IAG43_RS31045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG43_RS31050	COG1120	ATPase activity
IAG43_RS31060	COG1073	alpha beta
IAG43_RS31075	COG1132	(ABC) transporter
IAG43_RS31080	COG1132	(ABC) transporter
IAG43_RS31085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAG43_RS31095	COG0254	rRNA binding
IAG43_RS31100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAG43_RS31105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IAG43_RS31110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAG43_RS31115	COG2826	transposase and inactivated derivatives, IS30 family
IAG43_RS31135	COG0572	uridine kinase
IAG43_RS31235	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS31255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IAG43_RS31315	COG2018	Roadblock/LC7 domain
IAG43_RS31320	COG1063	alcohol dehydrogenase
IAG43_RS31325	COG0156	8-amino-7-oxononanoate synthase activity
IAG43_RS31330	COG0583	DNA-binding transcription factor activity
IAG43_RS31345	COG0583	DNA-binding transcription factor activity
IAG43_RS31355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAG43_RS31395	COG2226	methyltransferase
IAG43_RS31450	COG2409	Drug exporters of the RND superfamily
IAG43_RS31550	COG3387	PFAM Glycoside hydrolase 15-related
IAG43_RS31565	COG2124	cytochrome p450
IAG43_RS31610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG43_RS31620	COG2508	Transcriptional regulator
IAG43_RS31650	COG4989	oxidoreductase activity
IAG43_RS31670	COG1064	alcohol dehydrogenase
IAG43_RS31675	COG2235	arginine
IAG43_RS31695	COG5006	permease, DMT superfamily
IAG43_RS31720	COG1216	Glycosyl transferase, family 2
IAG43_RS31740	COG2723	6-phospho-beta-galactosidase activity
IAG43_RS31745	COG3833	ABC-type maltose transport systems, permease component
IAG43_RS31750	COG1175	transmembrane transport
IAG43_RS31760	COG1940	carbohydrate kinase activity
IAG43_RS31785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IAG43_RS31790	COG1349	DNA-binding transcription factor activity
IAG43_RS31795	COG1105	Belongs to the carbohydrate kinase PfkB family
IAG43_RS31800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAG43_RS31800	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IAG43_RS31800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAG43_RS31810	COG2326	polyphosphate kinase activity
IAG43_RS31820	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG43_RS31820	COG2172	sigma factor antagonist activity
IAG43_RS31820	COG2208	phosphoserine phosphatase activity
IAG43_RS31850	COG0395	ABC-type sugar transport system, permease component
IAG43_RS31855	COG1175	transmembrane transport
IAG43_RS31880	COG1175	transmembrane transport
IAG43_RS31885	COG0395	ABC-type sugar transport system, permease component
IAG43_RS31905	COG0673	inositol 2-dehydrogenase activity
IAG43_RS31910	COG2188	Transcriptional regulator
IAG43_RS31915	COG2188	Transcriptional regulator
IAG43_RS31925	COG2264	protein methyltransferase activity
IAG43_RS31930	COG3708	Transcriptional regulator
IAG43_RS31930	COG2207	Transcriptional regulator
IAG43_RS31935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IAG43_RS31940	COG1414	Transcriptional regulator
IAG43_RS31950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IAG43_RS31955	COG0667	Aldo Keto reductase
IAG43_RS31965	COG2076	Multidrug Resistance protein
IAG43_RS31990	COG4214	carbohydrate transport
IAG43_RS32015	COG0741	lytic transglycosylase activity
IAG43_RS32015	COG0739	heme binding
IAG43_RS32015	COG1196	nuclear chromosome segregation
IAG43_RS32040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IAG43_RS32050	COG1132	(ABC) transporter
IAG43_RS32090	COG2356	endonuclease I
IAG43_RS32155	COG0656	L-ascorbic acid biosynthetic process
IAG43_RS32185	COG0702	epimerase
IAG43_RS32220	COG0300	oxidoreductase activity
IAG43_RS32225	COG3548	integral membrane protein
IAG43_RS32265	COG1051	belongs to the nudix hydrolase family
IAG43_RS32275	COG3795	YCII-related domain
IAG43_RS32280	COG4941	Belongs to the sigma-70 factor family
IAG43_RS32340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAG43_RS32350	COG0515	serine threonine protein kinase
IAG43_RS32360	COG1132	(ABC) transporter
IAG43_RS32365	COG1132	(ABC) transporter
IAG43_RS32370	COG2197	response regulator
IAG43_RS32390	COG0366	Alpha amylase catalytic
IAG43_RS32395	COG0142	geranyltranstransferase activity
IAG43_RS32410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IAG43_RS32460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IAG43_RS32485	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IAG43_RS32490	COG0714	Associated with various cellular activities
IAG43_RS32510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAG43_RS32520	COG1012	belongs to the aldehyde dehydrogenase family
IAG43_RS32525	COG0659	secondary active sulfate transmembrane transporter activity
IAG43_RS32530	COG0789	Transcriptional regulator
IAG43_RS32565	COG0640	Transcriptional regulator
IAG43_RS32575	COG0640	Transcriptional regulator
IAG43_RS32625	COG0420	3'-5' exonuclease activity
IAG43_RS32630	COG0419	ATPase involved in DNA repair
IAG43_RS32680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAG43_RS32690	COG1017	nitric oxide dioxygenase activity
IAG43_RS32690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAG43_RS32700	COG0783	Belongs to the Dps family
IAG43_RS32725	COG3629	intracellular signal transduction
IAG43_RS32725	COG3903	Transcriptional regulator
IAG43_RS32800	COG0596	Alpha beta hydrolase
IAG43_RS32845	COG0583	DNA-binding transcription factor activity
IAG43_RS32935	COG4948	Mandelate Racemase Muconate Lactonizing
IAG43_RS32940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG43_RS32955	COG0667	Aldo Keto reductase
IAG43_RS32965	COG3835	regulator
IAG43_RS33070	COG0604	alcohol dehydrogenase
IAG43_RS33110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IAG43_RS33140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAG43_RS33150	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IAG43_RS33220	COG0604	alcohol dehydrogenase
IAG43_RS33220	COG3321	synthase
IAG43_RS33425	COG1475	DNA binding
IAG43_RS33530	COG2197	response regulator
IAG43_RS33585	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IAG43_RS33620	COG0529	Catalyzes the synthesis of activated sulfate
IAG43_RS33620	COG2046	Belongs to the sulfate adenylyltransferase family
IAG43_RS33650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IAG43_RS33660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAG43_RS33665	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IAG43_RS33675	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG43_RS33710	COG3321	synthase
IAG43_RS33710	COG0604	alcohol dehydrogenase
IAG43_RS33715	COG0604	alcohol dehydrogenase
IAG43_RS33715	COG3321	synthase
IAG43_RS33735	COG0604	alcohol dehydrogenase
IAG43_RS33735	COG3321	synthase
IAG43_RS33740	COG0477	Major facilitator Superfamily
IAG43_RS33755	COG0702	epimerase
IAG43_RS33765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IAG43_RS33775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAG43_RS33800	COG3321	synthase
IAG43_RS33800	COG0604	alcohol dehydrogenase
IAG43_RS33810	COG1051	belongs to the nudix hydrolase family
IAG43_RS33875	COG0305	Participates in initiation and elongation during chromosome replication
IAG43_RS33885	COG0019	diaminopimelate decarboxylase activity
IAG43_RS33890	COG2186	Transcriptional regulator
IAG43_RS33940	COG0741	lytic transglycosylase activity
IAG43_RS33940	COG1196	nuclear chromosome segregation
IAG43_RS33940	COG0739	heme binding
IAG43_RS33995	COG1475	DNA binding
IAG43_RS34000	COG1192	Involved in chromosome partitioning
IAG43_RS34025	COG1857	crispr-associated protein
IAG43_RS34040	COG1518	maintenance of DNA repeat elements
IAG43_RS34045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease