locus-tag	class	description
LXH13_RS00100	COG1609	Transcriptional regulator
LXH13_RS00110	COG3250	beta-galactosidase activity
LXH13_RS00115	COG3833	ABC-type maltose transport systems, permease component
LXH13_RS00120	COG1175	transmembrane transport
LXH13_RS00155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LXH13_RS00195	COG2909	trisaccharide binding
LXH13_RS00205	COG3485	protocatechuate 3,4-dioxygenase
LXH13_RS00225	COG0183	Belongs to the thiolase family
LXH13_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS00275	COG0583	DNA-binding transcription factor activity
LXH13_RS00280	COG1309	transcriptional regulator
LXH13_RS00285	COG0667	Aldo Keto reductase
LXH13_RS00310	COG3433	isochorismatase activity
LXH13_RS00310	COG1535	isochorismatase
LXH13_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS00325	COG1024	Enoyl-CoA hydratase
LXH13_RS00350	COG0483	inositol monophosphate 1-phosphatase activity
LXH13_RS00355	COG0583	DNA-binding transcription factor activity
LXH13_RS00375	COG1595	DNA-templated transcription, initiation
LXH13_RS00390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LXH13_RS00400	COG0583	DNA-binding transcription factor activity
LXH13_RS00440	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LXH13_RS00445	COG1082	Xylose isomerase domain protein TIM barrel
LXH13_RS00450	COG1063	alcohol dehydrogenase
LXH13_RS00465	COG0395	ABC-type sugar transport system, permease component
LXH13_RS00485	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS00500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LXH13_RS00535	COG4974	Belongs to the 'phage' integrase family
LXH13_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS00645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LXH13_RS00670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXH13_RS00715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LXH13_RS00735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LXH13_RS00740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXH13_RS00760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LXH13_RS00780	COG1131	(ABC) transporter
LXH13_RS00790	COG1595	DNA-templated transcription, initiation
LXH13_RS00805	COG1472	Belongs to the glycosyl hydrolase 3 family
LXH13_RS00815	COG3507	Belongs to the glycosyl hydrolase 43 family
LXH13_RS00830	COG3408	Glycogen debranching enzyme
LXH13_RS00855	COG1819	glycosyl
LXH13_RS00865	COG0069	glutamate synthase activity
LXH13_RS00885	COG1175	transmembrane transport
LXH13_RS00890	COG0395	ABC-type sugar transport system, permease component
LXH13_RS00895	COG1609	Transcriptional regulator
LXH13_RS00930	COG0693	protein deglycase activity
LXH13_RS00950	COG0395	ABC-type sugar transport system, permease component
LXH13_RS00955	COG1501	Belongs to the glycosyl hydrolase 31 family
LXH13_RS00985	COG0395	ABC-type sugar transport system, permease component
LXH13_RS01000	COG2188	Transcriptional regulator
LXH13_RS01015	COG2205	protein histidine kinase activity
LXH13_RS01050	COG0395	ABC-type sugar transport system, permease component
LXH13_RS01065	COG1609	Transcriptional regulator
LXH13_RS01070	COG0583	DNA-binding transcription factor activity
LXH13_RS01075	COG0251	oxidation-reduction process
LXH13_RS01105	COG0477	Major facilitator Superfamily
LXH13_RS01115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LXH13_RS01145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LXH13_RS01170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LXH13_RS01215	COG1846	Transcriptional regulator
LXH13_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS01270	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS01275	COG0477	Major facilitator Superfamily
LXH13_RS01290	COG1295	ribonuclease BN
LXH13_RS01295	COG2814	Major facilitator Superfamily
LXH13_RS01305	COG2770	Histidine kinase
LXH13_RS01305	COG2208	phosphoserine phosphatase activity
LXH13_RS01310	COG0596	Alpha beta hydrolase
LXH13_RS01325	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS01330	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS01365	COG0300	oxidoreductase activity
LXH13_RS01370	COG0577	efflux transmembrane transporter activity
LXH13_RS01370	COG1136	(ABC) transporter
LXH13_RS01380	COG1309	transcriptional regulator
LXH13_RS01390	COG3119	arylsulfatase activity
LXH13_RS01415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LXH13_RS01420	COG0477	Major facilitator Superfamily
LXH13_RS01425	COG3387	PFAM Glycoside hydrolase 15-related
LXH13_RS01495	COG1131	(ABC) transporter
LXH13_RS01500	COG3158	transport of potassium into the cell
LXH13_RS01505	COG1090	epimerase
LXH13_RS01550	COG1940	carbohydrate kinase activity
LXH13_RS01555	COG3345	alpha-galactosidase
LXH13_RS01565	COG0395	ABC-type sugar transport system, permease component
LXH13_RS01575	COG3458	cephalosporin-C deacetylase activity
LXH13_RS01590	COG1609	Transcriptional regulator
LXH13_RS01605	COG0395	ABC-type sugar transport system, permease component
LXH13_RS01650	COG3548	integral membrane protein
LXH13_RS01660	COG2814	Major facilitator Superfamily
LXH13_RS01665	COG1247	-acetyltransferase
LXH13_RS01670	COG1396	sequence-specific DNA binding
LXH13_RS01715	COG0583	DNA-binding transcription factor activity
LXH13_RS01760	COG0009	L-threonylcarbamoyladenylate synthase
LXH13_RS01780	COG2226	methyltransferase
LXH13_RS01785	COG0640	Transcriptional regulator
LXH13_RS01790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LXH13_RS01795	COG0531	amino acid
LXH13_RS01805	COG2205	protein histidine kinase activity
LXH13_RS01810	COG0745	RESPONSE REGULATOR receiver
LXH13_RS01865	COG2207	Transcriptional regulator
LXH13_RS01870	COG2223	nitrite transmembrane transporter activity
LXH13_RS01885	COG2197	response regulator
LXH13_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS01905	COG1793	dna ligase
LXH13_RS01925	COG2409	Drug exporters of the RND superfamily
LXH13_RS01935	COG0667	Aldo Keto reductase
LXH13_RS01945	COG0477	Major facilitator Superfamily
LXH13_RS01965	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS01970	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS01980	COG1454	alcohol dehydrogenase
LXH13_RS01990	COG0723	plastoquinol--plastocyanin reductase activity
LXH13_RS01990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LXH13_RS02000	COG1335	isochorismatase
LXH13_RS02015	COG3387	PFAM Glycoside hydrolase 15-related
LXH13_RS02040	COG0709	Synthesizes selenophosphate from selenide and ATP
LXH13_RS02055	COG0437	4 iron, 4 sulfur cluster binding
LXH13_RS02070	COG2814	Major facilitator Superfamily
LXH13_RS02075	COG0181	hydroxymethylbilane synthase activity
LXH13_RS02085	COG0842	Transport permease protein
LXH13_RS02125	COG0366	Alpha amylase catalytic
LXH13_RS02140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LXH13_RS02145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LXH13_RS02165	COG1366	Belongs to the anti-sigma-factor antagonist family
LXH13_RS02170	COG1366	Belongs to the anti-sigma-factor antagonist family
LXH13_RS02175	COG1366	Belongs to the anti-sigma-factor antagonist family
LXH13_RS02180	COG2172	sigma factor antagonist activity
LXH13_RS02195	COG1252	NADH dehydrogenase
LXH13_RS02235	COG1982	Orn Lys Arg decarboxylase major
LXH13_RS02245	COG0477	Major facilitator Superfamily
LXH13_RS02275	COG5002	protein histidine kinase activity
LXH13_RS02325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXH13_RS02360	COG1672	PFAM Archaeal ATPase
LXH13_RS02360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS02375	COG3345	alpha-galactosidase
LXH13_RS02380	COG1846	Transcriptional regulator
LXH13_RS02380	COG1940	carbohydrate kinase activity
LXH13_RS02390	COG2340	Cysteine-rich secretory protein family
LXH13_RS02405	COG0142	geranyltranstransferase activity
LXH13_RS02425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS02435	COG3647	Membrane
LXH13_RS02450	COG0667	Aldo Keto reductase
LXH13_RS02460	COG2814	Major facilitator Superfamily
LXH13_RS02465	COG0328	RNA-DNA hybrid ribonuclease activity
LXH13_RS02480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LXH13_RS02490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LXH13_RS02505	COG0596	Alpha beta hydrolase
LXH13_RS02510	COG0740	serine-type endopeptidase activity
LXH13_RS02515	COG0740	serine-type endopeptidase activity
LXH13_RS02525	COG1191	sigma factor activity
LXH13_RS02555	COG0842	Transport permease protein
LXH13_RS02555	COG1131	(ABC) transporter
LXH13_RS02555	COG1716	ATPase activity
LXH13_RS02580	COG0667	Aldo Keto reductase
LXH13_RS02585	COG0583	DNA-binding transcription factor activity
LXH13_RS02595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LXH13_RS02600	COG0346	lactoylglutathione lyase activity
LXH13_RS02620	COG0667	Aldo Keto reductase
LXH13_RS02640	COG0640	Transcriptional regulator
LXH13_RS02645	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS02650	COG4941	Belongs to the sigma-70 factor family
LXH13_RS02675	COG0702	epimerase
LXH13_RS02685	COG3046	protein related to deoxyribodipyrimidine photolyase
LXH13_RS02725	COG0531	amino acid
LXH13_RS02730	COG1940	carbohydrate kinase activity
LXH13_RS02735	COG3250	beta-galactosidase activity
LXH13_RS02760	COG1309	transcriptional regulator
LXH13_RS02825	COG2159	amidohydrolase
LXH13_RS02830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LXH13_RS02850	COG2267	carboxylic ester hydrolase activity
LXH13_RS02855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LXH13_RS02875	COG0588	phosphoglycerate mutase activity
LXH13_RS02885	COG4819	ethanolamine utilization protein
LXH13_RS02900	COG1178	ABC-type Fe3 transport system permease component
LXH13_RS02905	COG3842	ATPase activity
LXH13_RS02920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LXH13_RS02930	COG2186	Transcriptional regulator
LXH13_RS03000	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS03010	COG2070	2-Nitropropane dioxygenase
LXH13_RS03015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS03050	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS03070	COG2376	Dihydroxyacetone kinase
LXH13_RS03075	COG1461	Dihydroxyacetone kinase
LXH13_RS03080	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LXH13_RS03105	COG0446	pyridine nucleotide-disulphide oxidoreductase
LXH13_RS03105	COG1902	pentaerythritol trinitrate reductase activity
LXH13_RS03130	COG2890	protein-(glutamine-N5) methyltransferase activity
LXH13_RS03155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LXH13_RS03170	COG3458	cephalosporin-C deacetylase activity
LXH13_RS03180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS03185	COG2188	Transcriptional regulator
LXH13_RS03220	COG4941	Belongs to the sigma-70 factor family
LXH13_RS03230	COG3795	YCII-related domain
LXH13_RS03235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS03260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LXH13_RS03265	COG2050	protein possibly involved in aromatic compounds catabolism
LXH13_RS03270	COG2226	methyltransferase
LXH13_RS03280	COG0596	Alpha beta hydrolase
LXH13_RS03285	COG4941	Belongs to the sigma-70 factor family
LXH13_RS03290	COG3795	YCII-related domain
LXH13_RS03295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LXH13_RS03295	COG1017	nitric oxide dioxygenase activity
LXH13_RS03305	COG1686	Belongs to the peptidase S11 family
LXH13_RS03325	COG2066	Belongs to the glutaminase family
LXH13_RS03335	COG2186	Transcriptional regulator
LXH13_RS03340	COG1968	undecaprenyl-diphosphatase activity
LXH13_RS03345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LXH13_RS03350	COG1993	acr, cog1993
LXH13_RS03355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LXH13_RS03375	COG1846	Transcriptional regulator
LXH13_RS03410	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS03415	COG3340	Belongs to the peptidase S51 family
LXH13_RS03430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LXH13_RS03445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LXH13_RS03450	COG2197	response regulator
LXH13_RS03465	COG1309	transcriptional regulator
LXH13_RS03480	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS03485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXH13_RS03485	COG0045	succinate-CoA ligase (ADP-forming) activity
LXH13_RS03485	COG1042	CoA-binding domain protein
LXH13_RS03515	COG1176	ABC-type spermidine putrescine transport system, permease component I
LXH13_RS03520	COG1177	transmembrane transport
LXH13_RS03525	COG3842	ATPase activity
LXH13_RS03535	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS03550	COG2340	Cysteine-rich secretory protein family
LXH13_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS03590	COG1051	belongs to the nudix hydrolase family
LXH13_RS03610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LXH13_RS03615	COG0463	Glycosyl transferase, family 2
LXH13_RS03630	COG0633	Ferredoxin
LXH13_RS03630	COG3217	Mosc domain protein beta barrel domain protein
LXH13_RS03650	COG1349	DNA-binding transcription factor activity
LXH13_RS03675	COG1136	(ABC) transporter
LXH13_RS03675	COG0577	efflux transmembrane transporter activity
LXH13_RS03680	COG1136	(ABC) transporter
LXH13_RS03715	COG2313	pseudouridylate synthase activity
LXH13_RS03720	COG1522	sequence-specific DNA binding
LXH13_RS03720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXH13_RS03730	COG1940	carbohydrate kinase activity
LXH13_RS03740	COG2813	Specifically methylates the guanine in position
LXH13_RS03750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LXH13_RS03755	COG1349	DNA-binding transcription factor activity
LXH13_RS03760	COG3387	PFAM Glycoside hydrolase 15-related
LXH13_RS03820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LXH13_RS03845	COG0395	ABC-type sugar transport system, permease component
LXH13_RS03850	COG1175	transmembrane transport
LXH13_RS03885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LXH13_RS03890	COG0789	Transcriptional regulator
LXH13_RS03895	COG2226	methyltransferase
LXH13_RS03905	COG0673	inositol 2-dehydrogenase activity
LXH13_RS03945	COG1595	DNA-templated transcription, initiation
LXH13_RS03955	COG3903	Transcriptional regulator
LXH13_RS03955	COG3629	intracellular signal transduction
LXH13_RS03960	COG0596	Alpha beta hydrolase
LXH13_RS03965	COG1609	Transcriptional regulator
LXH13_RS03975	COG2814	Major facilitator Superfamily
LXH13_RS03985	COG3537	Alpha-1,2-mannosidase
LXH13_RS04010	COG0515	serine threonine protein kinase
LXH13_RS04025	COG1653	transport
LXH13_RS04035	COG1063	alcohol dehydrogenase
LXH13_RS04045	COG4213	ABC transporter substrate-binding protein
LXH13_RS04055	COG4214	carbohydrate transport
LXH13_RS04065	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS04070	COG2223	nitrite transmembrane transporter activity
LXH13_RS04100	COG1472	Belongs to the glycosyl hydrolase 3 family
LXH13_RS04105	COG2188	Transcriptional regulator
LXH13_RS04115	COG1376	ErfK ybiS ycfS ynhG family protein
LXH13_RS04140	COG2197	response regulator
LXH13_RS04145	COG4585	Histidine kinase
LXH13_RS04160	COG0492	ferredoxin-NADP+ reductase activity
LXH13_RS04170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXH13_RS04180	COG4608	Belongs to the ABC transporter superfamily
LXH13_RS04200	COG4166	transmembrane transport
LXH13_RS04205	COG1660	Displays ATPase and GTPase activities
LXH13_RS04220	COG3345	alpha-galactosidase
LXH13_RS04240	COG2815	serine threonine protein kinase
LXH13_RS04240	COG0515	serine threonine protein kinase
LXH13_RS04260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LXH13_RS04285	COG0204	Acyl-transferase
LXH13_RS04315	COG0584	glycerophosphoryl diester phosphodiesterase
LXH13_RS04355	COG0671	phosphoesterase, PA-phosphatase related
LXH13_RS04380	COG2233	PERMEase
LXH13_RS04385	COG0640	Transcriptional regulator
LXH13_RS04390	COG1902	pentaerythritol trinitrate reductase activity
LXH13_RS04405	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS04440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LXH13_RS04470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LXH13_RS04480	COG4770	biotin carboxylase activity
LXH13_RS04490	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS04490	COG1672	PFAM Archaeal ATPase
LXH13_RS04500	COG0701	Predicted permease
LXH13_RS04545	COG0235	Class ii aldolase
LXH13_RS04580	COG0667	Aldo Keto reductase
LXH13_RS04585	COG1733	regulation of RNA biosynthetic process
LXH13_RS04595	COG0714	Associated with various cellular activities
LXH13_RS04605	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS04665	COG2124	cytochrome p450
LXH13_RS04690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LXH13_RS04695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXH13_RS04705	COG0662	Cupin 2, conserved barrel domain protein
LXH13_RS04710	COG2329	Antibiotic biosynthesis monooxygenase
LXH13_RS04790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LXH13_RS04795	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LXH13_RS04800	COG0432	Pfam Uncharacterised protein family UPF0047
LXH13_RS04805	COG2072	flavoprotein involved in K transport
LXH13_RS04815	COG1132	(ABC) transporter
LXH13_RS04830	COG1132	(ABC) transporter
LXH13_RS04835	COG1132	(ABC) transporter
LXH13_RS04860	COG0254	rRNA binding
LXH13_RS04875	COG1946	Acyl-CoA thioesterase
LXH13_RS04885	COG2018	Roadblock/LC7 domain
LXH13_RS04925	COG3239	Fatty acid desaturase
LXH13_RS04930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LXH13_RS04965	COG1846	Transcriptional regulator
LXH13_RS04965	COG1940	carbohydrate kinase activity
LXH13_RS04970	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LXH13_RS04975	COG1113	amino acid transport
LXH13_RS04995	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS05005	COG1136	(ABC) transporter
LXH13_RS05015	COG0300	oxidoreductase activity
LXH13_RS05025	COG4221	oxidoreductase activity
LXH13_RS05045	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS05070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXH13_RS05075	COG0179	Fumarylacetoacetate (FAA) hydrolase
LXH13_RS05085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LXH13_RS05090	COG1408	metallophosphoesterase
LXH13_RS05095	COG3537	Alpha-1,2-mannosidase
LXH13_RS05105	COG3483	tryptophan 2,3-dioxygenase activity
LXH13_RS05130	COG1937	Protein conserved in bacteria
LXH13_RS05215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LXH13_RS05220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LXH13_RS05235	COG4176	ABC-type proline glycine betaine transport system permease component
LXH13_RS05240	COG4175	Glycine betaine
LXH13_RS05240	COG0517	IMP dehydrogenase activity
LXH13_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS05260	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LXH13_RS05280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LXH13_RS05300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LXH13_RS05310	COG3386	PFAM SMP-30 Gluconolaconase
LXH13_RS05315	COG0800	Aldolase
LXH13_RS05325	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS05345	COG0395	ABC-type sugar transport system, permease component
LXH13_RS05350	COG1175	transmembrane transport
LXH13_RS05360	COG3345	alpha-galactosidase
LXH13_RS05365	COG3250	beta-galactosidase activity
LXH13_RS05370	COG2197	response regulator
LXH13_RS05380	COG1136	(ABC) transporter
LXH13_RS05380	COG0577	efflux transmembrane transporter activity
LXH13_RS05410	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS05415	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS05430	COG0492	ferredoxin-NADP+ reductase activity
LXH13_RS05435	COG1793	dna ligase
LXH13_RS05445	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS05460	COG3424	synthase
LXH13_RS05465	COG2124	cytochrome p450
LXH13_RS05475	COG0577	efflux transmembrane transporter activity
LXH13_RS05480	COG1136	(ABC) transporter
LXH13_RS05485	COG4585	Histidine kinase
LXH13_RS05490	COG2197	response regulator
LXH13_RS05495	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS05510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LXH13_RS05515	COG3442	glutamine amidotransferase
LXH13_RS05520	COG0205	6-phosphofructokinase activity
LXH13_RS05535	COG2815	serine threonine protein kinase
LXH13_RS05535	COG0515	serine threonine protein kinase
LXH13_RS05545	COG3275	phosphorelay sensor kinase activity
LXH13_RS05550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXH13_RS05560	COG3279	Response regulator of the LytR AlgR family
LXH13_RS05565	COG1522	sequence-specific DNA binding
LXH13_RS05570	COG1834	amidinotransferase
LXH13_RS05575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LXH13_RS05600	COG0829	nickel cation binding
LXH13_RS05605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LXH13_RS05615	COG0804	urea catabolic process
LXH13_RS05620	COG0832	Belongs to the urease beta subunit family
LXH13_RS05625	COG0831	urea catabolic process
LXH13_RS05630	COG1309	transcriptional regulator
LXH13_RS05645	COG0740	serine-type endopeptidase activity
LXH13_RS05680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LXH13_RS05685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LXH13_RS05690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LXH13_RS05705	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
LXH13_RS05710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LXH13_RS05720	COG2133	pyrroloquinoline quinone binding
LXH13_RS05740	COG1136	(ABC) transporter
LXH13_RS05745	COG0577	efflux transmembrane transporter activity
LXH13_RS05780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LXH13_RS05795	COG1940	carbohydrate kinase activity
LXH13_RS05800	COG2188	Transcriptional regulator
LXH13_RS05805	COG1595	DNA-templated transcription, initiation
LXH13_RS05815	COG0596	Alpha beta hydrolase
LXH13_RS05825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXH13_RS05850	COG0626	cystathionine gamma-synthase activity
LXH13_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS05880	COG1522	sequence-specific DNA binding
LXH13_RS05885	COG0419	ATPase involved in DNA repair
LXH13_RS05890	COG0420	3'-5' exonuclease activity
LXH13_RS05895	COG1739	Uncharacterized protein family UPF0029
LXH13_RS05905	COG0215	cysteine-tRNA ligase activity
LXH13_RS05910	COG1832	CoA-binding protein
LXH13_RS05915	COG0531	amino acid
LXH13_RS05925	COG0640	Transcriptional regulator
LXH13_RS05960	COG0110	maltose O-acetyltransferase activity
LXH13_RS06010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LXH13_RS06040	COG2188	Transcriptional regulator
LXH13_RS06045	COG2226	methyltransferase
LXH13_RS06050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LXH13_RS06370	COG0463	Glycosyl transferase, family 2
LXH13_RS06500	COG0183	Belongs to the thiolase family
LXH13_RS06515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS06525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LXH13_RS06545	COG2318	DinB family
LXH13_RS06560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LXH13_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS06610	COG0697	spore germination
LXH13_RS06675	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LXH13_RS06715	COG0395	ABC-type sugar transport system, permease component
LXH13_RS06720	COG1175	transmembrane transport
LXH13_RS06730	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LXH13_RS06735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LXH13_RS06740	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LXH13_RS06760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LXH13_RS06760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LXH13_RS06770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LXH13_RS06790	COG1716	ATPase activity
LXH13_RS06810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LXH13_RS06840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LXH13_RS06855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXH13_RS06860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LXH13_RS06875	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LXH13_RS06885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LXH13_RS06890	COG3706	GGDEF domain
LXH13_RS06895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LXH13_RS06915	COG2018	Roadblock/LC7 domain
LXH13_RS06950	COG2814	Major facilitator Superfamily
LXH13_RS06955	COG4336	lyase activity
LXH13_RS06960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LXH13_RS06965	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LXH13_RS06970	COG1984	allophanate hydrolase subunit 2
LXH13_RS06975	COG2755	lipolytic protein G-D-S-L family
LXH13_RS06980	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS06985	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS07010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXH13_RS07015	COG2364	Membrane
LXH13_RS07025	COG2270	Major facilitator Superfamily
LXH13_RS07040	COG1216	Glycosyl transferase, family 2
LXH13_RS07075	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS07135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LXH13_RS07140	COG0140	phosphoribosyl-ATP diphosphatase activity
LXH13_RS07145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LXH13_RS07150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXH13_RS07150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXH13_RS07155	COG3201	nicotinamide mononucleotide transporter
LXH13_RS07170	COG0702	epimerase
LXH13_RS07175	COG1940	carbohydrate kinase activity
LXH13_RS07175	COG1846	Transcriptional regulator
LXH13_RS07180	COG2223	nitrite transmembrane transporter activity
LXH13_RS07190	COG2233	PERMEase
LXH13_RS07215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LXH13_RS07230	COG0531	amino acid
LXH13_RS07245	COG2390	Transcriptional regulator
LXH13_RS07250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LXH13_RS07255	COG2409	Drug exporters of the RND superfamily
LXH13_RS07265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LXH13_RS07280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LXH13_RS07290	COG1758	RNA polymerase activity
LXH13_RS07295	COG0194	GDP metabolic process
LXH13_RS07305	COG0284	orotidine-5'-phosphate decarboxylase activity
LXH13_RS07310	COG0167	dihydroorotate dehydrogenase activity
LXH13_RS07315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LXH13_RS07320	COG0505	Belongs to the CarA family
LXH13_RS07330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LXH13_RS07335	COG0540	Belongs to the ATCase OTCase family
LXH13_RS07340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LXH13_RS07350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LXH13_RS07355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LXH13_RS07360	COG0006	proline dipeptidase activity
LXH13_RS07370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LXH13_RS07375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LXH13_RS07380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LXH13_RS07390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LXH13_RS07400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LXH13_RS07405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LXH13_RS07425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LXH13_RS07440	COG1131	(ABC) transporter
LXH13_RS07450	COG4585	Histidine kinase
LXH13_RS07455	COG2197	response regulator
LXH13_RS07460	COG0124	histidyl-tRNA synthetase
LXH13_RS07470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LXH13_RS07475	COG1196	nuclear chromosome segregation
LXH13_RS07480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LXH13_RS07485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LXH13_RS07490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LXH13_RS07495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LXH13_RS07505	COG2255	four-way junction helicase activity
LXH13_RS07510	COG0632	four-way junction helicase activity
LXH13_RS07515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LXH13_RS07520	COG0217	transcriptional regulatory protein
LXH13_RS07525	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LXH13_RS07530	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LXH13_RS07540	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS07545	COG1560	Kdo2-lipid A biosynthetic process
LXH13_RS07550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LXH13_RS07570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LXH13_RS07575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LXH13_RS07590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LXH13_RS07655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LXH13_RS07710	COG2816	NAD+ diphosphatase activity
LXH13_RS07720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LXH13_RS07720	COG1648	precorrin-2 dehydrogenase activity
LXH13_RS07725	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LXH13_RS07740	COG1464	Belongs to the NlpA lipoprotein family
LXH13_RS07745	COG2011	ABC-type metal ion transport system permease component
LXH13_RS07750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LXH13_RS07785	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS07785	COG0204	Acyl-transferase
LXH13_RS07790	COG0477	Major facilitator Superfamily
LXH13_RS07805	COG0165	Argininosuccinate lyase
LXH13_RS07825	COG2205	protein histidine kinase activity
LXH13_RS07830	COG0745	RESPONSE REGULATOR receiver
LXH13_RS07860	COG1438	arginine binding
LXH13_RS07865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LXH13_RS07870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LXH13_RS07875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LXH13_RS07880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LXH13_RS07925	COG0697	spore germination
LXH13_RS07935	COG1649	PFAM Uncharacterised BCR, COG1649
LXH13_RS07965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LXH13_RS07965	COG0072	phenylalanine-tRNA ligase activity
LXH13_RS07970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LXH13_RS07975	COG5002	protein histidine kinase activity
LXH13_RS07980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LXH13_RS07985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LXH13_RS07990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LXH13_RS07995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LXH13_RS08040	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS08045	COG0174	glutamine synthetase
LXH13_RS08055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LXH13_RS08070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LXH13_RS08080	COG4176	ABC-type proline glycine betaine transport system permease component
LXH13_RS08085	COG4175	Glycine betaine
LXH13_RS08085	COG0517	IMP dehydrogenase activity
LXH13_RS08090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LXH13_RS08155	COG0805	protein transport
LXH13_RS08160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LXH13_RS08190	COG0545	Peptidyl-prolyl cis-trans isomerase
LXH13_RS08195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LXH13_RS08205	COG1609	Transcriptional regulator
LXH13_RS08210	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LXH13_RS08215	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LXH13_RS08230	COG4122	O-methyltransferase activity
LXH13_RS08235	COG1222	aaa ATPase
LXH13_RS08255	COG1994	Peptidase M50
LXH13_RS08255	COG0517	IMP dehydrogenase activity
LXH13_RS08265	COG2197	response regulator
LXH13_RS08270	COG0747	negative chemotaxis
LXH13_RS08275	COG4166	transmembrane transport
LXH13_RS08280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LXH13_RS08285	COG0646	methionine synthase
LXH13_RS08285	COG1410	methionine synthase
LXH13_RS08290	COG1414	Transcriptional regulator
LXH13_RS08295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LXH13_RS08300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LXH13_RS08305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LXH13_RS08310	COG2186	Transcriptional regulator
LXH13_RS08320	COG1404	Belongs to the peptidase S8 family
LXH13_RS08330	COG0215	cysteine-tRNA ligase activity
LXH13_RS08345	COG0588	phosphoglycerate mutase activity
LXH13_RS08350	COG0598	Magnesium transport protein CorA
LXH13_RS08360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS08365	COG0667	Aldo Keto reductase
LXH13_RS08415	COG0308	aminopeptidase N
LXH13_RS08490	COG1222	aaa ATPase
LXH13_RS08520	COG3012	SEC-C Motif Domain Protein
LXH13_RS08525	COG2186	Transcriptional regulator
LXH13_RS08530	COG3265	gluconokinase activity
LXH13_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS08545	COG1063	alcohol dehydrogenase
LXH13_RS08585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LXH13_RS08590	COG2149	membrane
LXH13_RS08620	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS08630	COG3876	Protein conserved in bacteria
LXH13_RS08680	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS08690	COG0640	Transcriptional regulator
LXH13_RS08725	COG0243	molybdopterin cofactor binding
LXH13_RS08730	COG1309	transcriptional regulator
LXH13_RS08740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LXH13_RS08745	COG2188	Transcriptional regulator
LXH13_RS08765	COG1595	DNA-templated transcription, initiation
LXH13_RS08790	COG2755	lipolytic protein G-D-S-L family
LXH13_RS08810	COG0726	polysaccharide deacetylase
LXH13_RS08835	COG1725	Transcriptional regulator
LXH13_RS08875	COG0662	Cupin 2, conserved barrel domain protein
LXH13_RS08875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LXH13_RS08880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LXH13_RS08885	COG0587	DNA-directed DNA polymerase activity
LXH13_RS08895	COG0330	HflC and HflK could
LXH13_RS08925	COG1799	cell septum assembly
LXH13_RS08930	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS08935	COG0477	Major facilitator Superfamily
LXH13_RS08945	COG0671	phosphoesterase, PA-phosphatase related
LXH13_RS08985	COG1129	ABC transporter
LXH13_RS09015	COG1160	GTP binding
LXH13_RS09025	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LXH13_RS09060	COG3541	Predicted nucleotidyltransferase
LXH13_RS09070	COG0494	nUDIX hydrolase
LXH13_RS09085	COG1187	pseudouridine synthase activity
LXH13_RS09090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LXH13_RS09095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LXH13_RS09110	COG0686	Belongs to the AlaDH PNT family
LXH13_RS09120	COG0494	nUDIX hydrolase
LXH13_RS09125	COG0504	CTP synthase activity
LXH13_RS09130	COG3387	PFAM Glycoside hydrolase 15-related
LXH13_RS09145	COG0297	glycogen (starch) synthase activity
LXH13_RS09155	COG0497	DNA recombination
LXH13_RS09160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LXH13_RS09180	COG1120	ATPase activity
LXH13_RS09190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXH13_RS09195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXH13_RS09200	COG0647	UMP catabolic process
LXH13_RS09235	COG2094	Belongs to the DNA glycosylase MPG family
LXH13_RS09245	COG1881	PFAM PEBP family protein
LXH13_RS09265	COG1119	ATPase activity
LXH13_RS09280	COG2197	response regulator
LXH13_RS09285	COG4585	Histidine kinase
LXH13_RS09290	COG4221	oxidoreductase activity
LXH13_RS09295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LXH13_RS09305	COG1131	(ABC) transporter
LXH13_RS09305	COG1716	ATPase activity
LXH13_RS09305	COG0842	Transport permease protein
LXH13_RS09315	COG0560	Phosphoserine phosphatase
LXH13_RS09315	COG3830	Belongs to the UPF0237 family
LXH13_RS09335	COG2186	Transcriptional regulator
LXH13_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS09365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LXH13_RS09385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LXH13_RS09390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXH13_RS09405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXH13_RS09415	COG1063	alcohol dehydrogenase
LXH13_RS09420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LXH13_RS09435	COG3387	PFAM Glycoside hydrolase 15-related
LXH13_RS09475	COG1024	Enoyl-CoA hydratase
LXH13_RS09485	COG0488	(ABC) transporter
LXH13_RS09500	COG0235	Class ii aldolase
LXH13_RS09520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LXH13_RS09525	COG1492	cobalamin metabolic process
LXH13_RS09545	COG1797	cobyrinic acid a,c-diamide synthase activity
LXH13_RS09600	COG1126	abc transporter atp-binding protein
LXH13_RS09605	COG0765	amino acid transport
LXH13_RS09610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXH13_RS09615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LXH13_RS09620	COG0456	acetyltransferase
LXH13_RS09625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LXH13_RS09630	COG1917	Cupin 2, conserved barrel domain protein
LXH13_RS09635	COG5285	phytanoyl-CoA dioxygenase
LXH13_RS09645	COG1595	DNA-templated transcription, initiation
LXH13_RS09670	COG0477	Major facilitator Superfamily
LXH13_RS09685	COG1414	Transcriptional regulator
LXH13_RS09695	COG4585	Histidine kinase
LXH13_RS09700	COG2197	response regulator
LXH13_RS09705	COG0768	penicillin binding
LXH13_RS09710	COG2252	PERMEase
LXH13_RS09730	COG4677	pectinesterase activity
LXH13_RS09735	COG4677	pectinesterase activity
LXH13_RS09745	COG2755	lipolytic protein G-D-S-L family
LXH13_RS09750	COG1653	transport
LXH13_RS09755	COG3507	Belongs to the glycosyl hydrolase 43 family
LXH13_RS09770	COG0395	ABC-type sugar transport system, permease component
LXH13_RS09775	COG1175	transmembrane transport
LXH13_RS09785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS09790	COG1802	Transcriptional regulator
LXH13_RS09815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS09820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LXH13_RS09825	COG1349	DNA-binding transcription factor activity
LXH13_RS09840	COG0395	ABC-type sugar transport system, permease component
LXH13_RS09845	COG1063	alcohol dehydrogenase
LXH13_RS09860	COG1802	Transcriptional regulator
LXH13_RS09920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS09930	COG2171	N-acyltransferase activity
LXH13_RS09935	COG3226	Transcriptional regulator
LXH13_RS09950	COG2151	metal-sulfur cluster biosynthetic enzyme
LXH13_RS09955	COG0822	iron-sulfur transferase activity
LXH13_RS09960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LXH13_RS09965	COG0396	ATPase activity
LXH13_RS09975	COG0719	Fe-S assembly protein
LXH13_RS09990	COG1131	(ABC) transporter
LXH13_RS10000	COG1612	heme a metabolic process
LXH13_RS10015	COG0109	protoheme IX farnesyltransferase activity
LXH13_RS10025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LXH13_RS10040	COG0363	glucosamine-6-phosphate deaminase activity
LXH13_RS10045	COG0395	ABC-type sugar transport system, permease component
LXH13_RS10050	COG1175	transmembrane transport
LXH13_RS10055	COG1653	transport
LXH13_RS10060	COG0366	Alpha amylase catalytic
LXH13_RS10070	COG1695	Transcriptional regulator
LXH13_RS10075	COG1136	(ABC) transporter
LXH13_RS10075	COG0577	efflux transmembrane transporter activity
LXH13_RS10090	COG0166	Belongs to the GPI family
LXH13_RS10105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LXH13_RS10110	COG0149	triose-phosphate isomerase activity
LXH13_RS10115	COG0126	phosphoglycerate kinase activity
LXH13_RS10120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LXH13_RS10125	COG1481	regulation of sporulation
LXH13_RS10130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LXH13_RS10135	COG1660	Displays ATPase and GTPase activities
LXH13_RS10140	COG0322	excinuclease ABC activity
LXH13_RS10150	COG1609	Transcriptional regulator
LXH13_RS10160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LXH13_RS10175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXH13_RS10180	COG0765	amino acid transport
LXH13_RS10190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LXH13_RS10195	COG1619	proteins homologs of microcin C7 resistance protein MccF
LXH13_RS10200	COG0387	Pfam Sodium calcium exchanger
LXH13_RS10220	COG0556	nucleotide-excision repair
LXH13_RS10230	COG0584	glycerophosphoryl diester phosphodiesterase
LXH13_RS10235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LXH13_RS10240	COG1063	alcohol dehydrogenase
LXH13_RS10255	COG0598	Magnesium transport protein CorA
LXH13_RS10325	COG2124	cytochrome p450
LXH13_RS10330	COG0402	S-adenosylhomocysteine deaminase activity
LXH13_RS10355	COG2197	response regulator
LXH13_RS10375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LXH13_RS10380	COG1584	GPR1 FUN34 yaaH family protein
LXH13_RS10390	COG1953	Uracil, thiamine, allantoin
LXH13_RS10395	COG1802	Transcriptional regulator
LXH13_RS10400	COG2267	carboxylic ester hydrolase activity
LXH13_RS10440	COG0237	dephospho-CoA kinase activity
LXH13_RS10455	COG2226	methyltransferase
LXH13_RS10460	COG1643	Atp-dependent helicase
LXH13_RS10495	COG2050	protein possibly involved in aromatic compounds catabolism
LXH13_RS10570	COG4566	intracellular signal transduction
LXH13_RS10575	COG1605	Chorismate mutase
LXH13_RS10575	COG0287	Prephenate dehydrogenase
LXH13_RS10595	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS10605	COG1024	Enoyl-CoA hydratase
LXH13_RS10630	COG0183	Belongs to the thiolase family
LXH13_RS10635	COG1309	transcriptional regulator
LXH13_RS10640	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS10645	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS10655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXH13_RS10660	COG2304	oxidoreductase activity
LXH13_RS10675	COG0067	glutamate synthase
LXH13_RS10675	COG0069	glutamate synthase activity
LXH13_RS10675	COG0070	glutamate synthase
LXH13_RS10685	COG1397	ADP-ribosylglycohydrolase
LXH13_RS10705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXH13_RS10715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LXH13_RS10725	COG0159	tryptophan synthase activity
LXH13_RS10730	COG0133	tryptophan synthase activity
LXH13_RS10740	COG0134	indole-3-glycerol-phosphate synthase activity
LXH13_RS10760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LXH13_RS10765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LXH13_RS10785	COG0107	imidazoleglycerol-phosphate synthase activity
LXH13_RS10790	COG0251	oxidation-reduction process
LXH13_RS10795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LXH13_RS10800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LXH13_RS10810	COG0131	Imidazoleglycerol-phosphate dehydratase
LXH13_RS10815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LXH13_RS10820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LXH13_RS10840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LXH13_RS10860	COG1432	Conserved Protein
LXH13_RS10870	COG0587	DNA-directed DNA polymerase activity
LXH13_RS10925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LXH13_RS10935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LXH13_RS10940	COG3599	regulation of cell shape
LXH13_RS10950	COG1799	cell septum assembly
LXH13_RS10960	COG1496	oxidoreductase activity
LXH13_RS10965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LXH13_RS10970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LXH13_RS10975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LXH13_RS10985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LXH13_RS10990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LXH13_RS11000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LXH13_RS11005	COG0768	penicillin binding
LXH13_RS11015	COG0275	rRNA processing
LXH13_RS11025	COG0714	Associated with various cellular activities
LXH13_RS11045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LXH13_RS11055	COG1129	ABC transporter
LXH13_RS11065	COG1309	transcriptional regulator
LXH13_RS11085	COG0352	thiamine-phosphate diphosphorylase activity
LXH13_RS11100	COG2022	thiamine diphosphate biosynthetic process
LXH13_RS11100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LXH13_RS11110	COG2022	thiamine diphosphate biosynthetic process
LXH13_RS11115	COG0515	serine threonine protein kinase
LXH13_RS11115	COG2815	serine threonine protein kinase
LXH13_RS11120	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LXH13_RS11130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LXH13_RS11135	COG2193	ferroxidase activity
LXH13_RS11140	COG0243	molybdopterin cofactor binding
LXH13_RS11145	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LXH13_RS11155	COG0205	6-phosphofructokinase activity
LXH13_RS11190	COG1940	carbohydrate kinase activity
LXH13_RS11200	COG0003	Pfam Anion-transporting ATPase
LXH13_RS11235	COG0791	NLP P60 protein
LXH13_RS11235	COG3883	PFAM NLP P60 protein
LXH13_RS11265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LXH13_RS11270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LXH13_RS11275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXH13_RS11280	COG0723	plastoquinol--plastocyanin reductase activity
LXH13_RS11285	COG2010	Cytochrome c
LXH13_RS11290	COG1845	cytochrome c oxidase, subunit III
LXH13_RS11300	COG1376	ErfK ybiS ycfS ynhG family protein
LXH13_RS11310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LXH13_RS11315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LXH13_RS11325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXH13_RS11345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LXH13_RS11350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LXH13_RS11355	COG2197	response regulator
LXH13_RS11365	COG4585	Histidine kinase
LXH13_RS11390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXH13_RS11415	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LXH13_RS11420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LXH13_RS11420	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LXH13_RS11435	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LXH13_RS11445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LXH13_RS11450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LXH13_RS11455	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXH13_RS11465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LXH13_RS11470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LXH13_RS11505	COG1090	epimerase
LXH13_RS11520	COG0321	lipoyl(octanoyl) transferase activity
LXH13_RS11525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LXH13_RS11545	COG0174	glutamine synthetase
LXH13_RS11555	COG0501	Belongs to the peptidase M48B family
LXH13_RS11585	COG2201	protein-glutamate methylesterase activity
LXH13_RS11610	COG2267	carboxylic ester hydrolase activity
LXH13_RS11625	COG0745	RESPONSE REGULATOR receiver
LXH13_RS11640	COG2197	response regulator
LXH13_RS11685	COG0366	Alpha amylase catalytic
LXH13_RS11690	COG3833	ABC-type maltose transport systems, permease component
LXH13_RS11695	COG1175	transmembrane transport
LXH13_RS11705	COG1609	Transcriptional regulator
LXH13_RS11715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LXH13_RS11740	COG0174	glutamine synthetase
LXH13_RS11745	COG1017	nitric oxide dioxygenase activity
LXH13_RS11745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LXH13_RS11750	COG1959	2 iron, 2 sulfur cluster binding
LXH13_RS11795	COG0477	Major facilitator Superfamily
LXH13_RS11800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LXH13_RS11825	COG1994	Peptidase M50
LXH13_RS11880	COG2837	iron assimilation
LXH13_RS11885	COG0672	)-iron permease
LXH13_RS11910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS11915	COG2814	Major facilitator Superfamily
LXH13_RS11930	COG1686	Belongs to the peptidase S11 family
LXH13_RS11935	COG0667	Aldo Keto reductase
LXH13_RS11945	COG2259	Doxx family
LXH13_RS11955	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS11975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXH13_RS11990	COG2814	Major facilitator Superfamily
LXH13_RS12005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LXH13_RS12040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXH13_RS12050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LXH13_RS12055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LXH13_RS12080	COG0022	dehydrogenase e1 component
LXH13_RS12090	COG0513	Belongs to the DEAD box helicase family
LXH13_RS12095	COG1278	Cold shock
LXH13_RS12100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS12145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12150	COG0431	NADPH-dependent FMN reductase
LXH13_RS12155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12185	COG1126	abc transporter atp-binding protein
LXH13_RS12200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXH13_RS12230	COG4172	Belongs to the ABC transporter superfamily
LXH13_RS12335	COG3629	intracellular signal transduction
LXH13_RS12335	COG3903	Transcriptional regulator
LXH13_RS12370	COG0557	exoribonuclease II activity
LXH13_RS12375	COG3022	response to hydroperoxide
LXH13_RS12380	COG0800	Aldolase
LXH13_RS12405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LXH13_RS12430	COG2030	dehydratase
LXH13_RS12435	COG1131	(ABC) transporter
LXH13_RS12445	COG4585	Histidine kinase
LXH13_RS12455	COG2197	response regulator
LXH13_RS12465	COG0183	Belongs to the thiolase family
LXH13_RS12470	COG0477	Major facilitator Superfamily
LXH13_RS12480	COG3655	Transcriptional regulator
LXH13_RS12490	COG2247	cell wall binding repeat
LXH13_RS12490	COG0860	N-Acetylmuramoyl-L-alanine amidase
LXH13_RS12500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS12520	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS12525	COG1309	transcriptional regulator
LXH13_RS12555	COG0251	oxidation-reduction process
LXH13_RS12565	COG1657	PFAM Prenyltransferase squalene oxidase
LXH13_RS12580	COG3845	ABC transporter
LXH13_RS12600	COG3619	membrane
LXH13_RS12625	COG0183	Belongs to the thiolase family
LXH13_RS12630	COG2124	cytochrome p450
LXH13_RS12650	COG4122	O-methyltransferase activity
LXH13_RS12690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LXH13_RS12770	COG1358	cellular component organization or biogenesis
LXH13_RS12815	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LXH13_RS12820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LXH13_RS12830	COG0477	Major facilitator Superfamily
LXH13_RS12835	COG1309	transcriptional regulator
LXH13_RS12850	COG0667	Aldo Keto reductase
LXH13_RS12855	COG0789	Transcriptional regulator
LXH13_RS12870	COG1741	Belongs to the pirin family
LXH13_RS12885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LXH13_RS12890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LXH13_RS12895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXH13_RS12920	COG1309	transcriptional regulator
LXH13_RS12950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS12955	COG1764	response to oxidative stress
LXH13_RS12960	COG2130	NADP-dependent
LXH13_RS12975	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS12995	COG1129	ABC transporter
LXH13_RS13000	COG4214	carbohydrate transport
LXH13_RS13010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LXH13_RS13015	COG3507	Belongs to the glycosyl hydrolase 43 family
LXH13_RS13050	COG0395	ABC-type sugar transport system, permease component
LXH13_RS13055	COG1175	transmembrane transport
LXH13_RS13080	COG3386	PFAM SMP-30 Gluconolaconase
LXH13_RS13085	COG1414	Transcriptional regulator
LXH13_RS13125	COG4981	capsule polysaccharide biosynthetic process
LXH13_RS13145	COG2835	tetraacyldisaccharide 4'-kinase activity
LXH13_RS13180	COG2186	Transcriptional regulator
LXH13_RS13190	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS13195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LXH13_RS13195	COG0825	malonyl-CoA metabolic process
LXH13_RS13200	COG1404	Belongs to the peptidase S8 family
LXH13_RS13225	COG1077	Cell shape determining protein MreB Mrl
LXH13_RS13280	COG1070	Carbohydrate kinase
LXH13_RS13295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LXH13_RS13300	COG0358	DNA primase activity
LXH13_RS13310	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LXH13_RS13320	COG2949	membrane
LXH13_RS13325	COG0243	molybdopterin cofactor binding
LXH13_RS13340	COG1136	(ABC) transporter
LXH13_RS13380	COG3896	Chloramphenicol phosphotransferase-like protein
LXH13_RS13385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LXH13_RS13390	COG2146	nitrite reductase [NAD(P)H] activity
LXH13_RS13390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LXH13_RS13400	COG1309	transcriptional regulator
LXH13_RS13420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LXH13_RS13420	COG0574	Belongs to the PEP-utilizing enzyme family
LXH13_RS13445	COG0477	Major facilitator Superfamily
LXH13_RS13460	COG0477	Major facilitator Superfamily
LXH13_RS13480	COG0667	Aldo Keto reductase
LXH13_RS13500	COG0423	glycine-tRNA ligase activity
LXH13_RS13505	COG3443	Belongs to the bacterial solute-binding protein 9 family
LXH13_RS13505	COG0803	Belongs to the bacterial solute-binding protein 9 family
LXH13_RS13510	COG1121	(ABC) transporter
LXH13_RS13515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LXH13_RS13525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LXH13_RS13530	COG1381	Involved in DNA repair and RecF pathway recombination
LXH13_RS13560	COG1396	sequence-specific DNA binding
LXH13_RS13565	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
LXH13_RS13570	COG2197	response regulator
LXH13_RS13575	COG4585	Histidine kinase
LXH13_RS13580	COG1131	(ABC) transporter
LXH13_RS13610	COG2186	Transcriptional regulator
LXH13_RS13615	COG0747	negative chemotaxis
LXH13_RS13625	COG0444	Belongs to the ABC transporter superfamily
LXH13_RS13630	COG4608	Belongs to the ABC transporter superfamily
LXH13_RS13635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS13650	COG4585	Histidine kinase
LXH13_RS13655	COG2409	Drug exporters of the RND superfamily
LXH13_RS13665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LXH13_RS13680	COG2723	6-phospho-beta-galactosidase activity
LXH13_RS13695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LXH13_RS13740	COG2315	Protein conserved in bacteria
LXH13_RS13750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LXH13_RS13760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXH13_RS13765	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS13770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS13785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LXH13_RS13790	COG1234	tRNA 3'-trailer cleavage
LXH13_RS13795	COG0537	adenosine 5'-monophosphoramidase activity
LXH13_RS13800	COG4946	Tricorn protease homolog
LXH13_RS13800	COG0793	Belongs to the peptidase S41A family
LXH13_RS13825	COG0484	heat shock protein binding
LXH13_RS13830	COG1420	regulation of RNA biosynthetic process
LXH13_RS13855	COG2205	protein histidine kinase activity
LXH13_RS13855	COG0784	Response regulator, receiver
LXH13_RS13870	COG0481	GTPase activity
LXH13_RS13875	COG0268	Binds directly to 16S ribosomal RNA
LXH13_RS13890	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS13900	COG2197	response regulator
LXH13_RS13905	COG4585	Histidine kinase
LXH13_RS13930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LXH13_RS13935	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LXH13_RS13940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXH13_RS13945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXH13_RS13970	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS13980	COG0667	Aldo Keto reductase
LXH13_RS14015	COG1131	(ABC) transporter
LXH13_RS14030	COG1819	glycosyl
LXH13_RS14040	COG0477	Major facilitator Superfamily
LXH13_RS14050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LXH13_RS14065	COG0431	NADPH-dependent FMN reductase
LXH13_RS14110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXH13_RS14145	COG1307	EDD domain protein, DegV family
LXH13_RS14155	COG0495	leucyl-tRNA aminoacylation
LXH13_RS14165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LXH13_RS14190	COG0588	phosphoglycerate mutase activity
LXH13_RS14195	COG0799	negative regulation of ribosome biogenesis
LXH13_RS14205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LXH13_RS14220	COG0501	Belongs to the peptidase M48B family
LXH13_RS14235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LXH13_RS14245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LXH13_RS14255	COG1215	transferase activity, transferring glycosyl groups
LXH13_RS14275	COG3540	Alkaline phosphatase
LXH13_RS14280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LXH13_RS14285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LXH13_RS14290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LXH13_RS14295	COG1530	ribonuclease E activity
LXH13_RS14345	COG0539	negative regulation of cytoplasmic translation
LXH13_RS14375	COG2186	Transcriptional regulator
LXH13_RS14400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LXH13_RS14405	COG1518	maintenance of DNA repeat elements
LXH13_RS14450	COG0772	Belongs to the SEDS family
LXH13_RS14455	COG0768	penicillin binding
LXH13_RS14470	COG1077	Cell shape determining protein MreB Mrl
LXH13_RS14475	COG0105	UTP biosynthetic process
LXH13_RS14485	COG0285	dihydrofolate synthase activity
LXH13_RS14490	COG0525	valine-tRNA ligase activity
LXH13_RS14500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LXH13_RS14505	COG0740	serine-type endopeptidase activity
LXH13_RS14510	COG0740	serine-type endopeptidase activity
LXH13_RS14515	COG0544	peptidyl-prolyl cis-trans isomerase activity
LXH13_RS14540	COG3594	Acyltransferase
LXH13_RS14555	COG1136	(ABC) transporter
LXH13_RS14555	COG0577	efflux transmembrane transporter activity
LXH13_RS14565	COG4552	Acetyltransferase involved in intracellular survival and related
LXH13_RS14575	COG0698	ribose 5-phosphate isomerase
LXH13_RS14580	COG1113	amino acid transport
LXH13_RS14585	COG0515	serine threonine protein kinase
LXH13_RS14600	COG1940	carbohydrate kinase activity
LXH13_RS14610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXH13_RS14615	COG1116	anion transmembrane transporter activity
LXH13_RS14620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS14630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LXH13_RS14640	COG0588	phosphoglycerate mutase activity
LXH13_RS14650	COG1070	Carbohydrate kinase
LXH13_RS14655	COG1653	transport
LXH13_RS14660	COG1175	transmembrane transport
LXH13_RS14665	COG0395	ABC-type sugar transport system, permease component
LXH13_RS14670	COG3842	ATPase activity
LXH13_RS14675	COG1349	DNA-binding transcription factor activity
LXH13_RS14690	COG1070	Carbohydrate kinase
LXH13_RS14695	COG0584	glycerophosphoryl diester phosphodiesterase
LXH13_RS14710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LXH13_RS14795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LXH13_RS14830	COG0668	transmembrane transport
LXH13_RS14835	COG1940	carbohydrate kinase activity
LXH13_RS14845	COG1175	transmembrane transport
LXH13_RS14850	COG0395	ABC-type sugar transport system, permease component
LXH13_RS14855	COG1486	melibiose metabolic process
LXH13_RS14870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXH13_RS14900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LXH13_RS14905	COG2346	COG2346, Truncated hemoglobins
LXH13_RS14920	COG0577	efflux transmembrane transporter activity
LXH13_RS14920	COG1136	(ABC) transporter
LXH13_RS15040	COG0629	single-stranded DNA binding
LXH13_RS15050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LXH13_RS15060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LXH13_RS15070	COG1316	TRANSCRIPTIONal
LXH13_RS15075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LXH13_RS15080	COG0640	Transcriptional regulator
LXH13_RS15100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LXH13_RS15105	COG2304	oxidoreductase activity
LXH13_RS15155	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS15160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LXH13_RS15170	COG0728	peptidoglycan biosynthetic process
LXH13_RS15180	COG0297	glycogen (starch) synthase activity
LXH13_RS15205	COG2304	oxidoreductase activity
LXH13_RS15225	COG3962	Belongs to the TPP enzyme family
LXH13_RS15240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXH13_RS15280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LXH13_RS15290	COG1129	ABC transporter
LXH13_RS15300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXH13_RS15305	COG1869	D-ribose catabolic process
LXH13_RS15320	COG0673	inositol 2-dehydrogenase activity
LXH13_RS15325	COG1609	Transcriptional regulator
LXH13_RS15335	COG0456	acetyltransferase
LXH13_RS15335	COG1846	Transcriptional regulator
LXH13_RS15350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LXH13_RS15365	COG1472	Belongs to the glycosyl hydrolase 3 family
LXH13_RS15400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LXH13_RS15420	COG0028	Belongs to the TPP enzyme family
LXH13_RS15430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXH13_RS15455	COG1946	Acyl-CoA thioesterase
LXH13_RS15465	COG1309	transcriptional regulator
LXH13_RS15470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXH13_RS15485	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS15505	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LXH13_RS15540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LXH13_RS15550	COG0589	response to stress
LXH13_RS15560	COG4977	sequence-specific DNA binding
LXH13_RS15565	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LXH13_RS15605	COG3979	chitinase
LXH13_RS15615	COG0745	RESPONSE REGULATOR receiver
LXH13_RS15640	COG0406	alpha-ribazole phosphatase activity
LXH13_RS15690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS15720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXH13_RS15725	COG0765	amino acid transport
LXH13_RS15730	COG0765	amino acid transport
LXH13_RS15735	COG1126	abc transporter atp-binding protein
LXH13_RS15750	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS15755	COG3397	chitin binding
LXH13_RS15775	COG2186	Transcriptional regulator
LXH13_RS15815	COG0673	inositol 2-dehydrogenase activity
LXH13_RS15820	COG4702	Belongs to the UPF0303 family
LXH13_RS15830	COG0706	membrane insertase activity
LXH13_RS15850	COG1595	DNA-templated transcription, initiation
LXH13_RS15865	COG2610	gluconate transmembrane transporter activity
LXH13_RS15870	COG0251	oxidation-reduction process
LXH13_RS15875	COG1414	Transcriptional regulator
LXH13_RS15890	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LXH13_RS15900	COG0436	Aminotransferase
LXH13_RS15915	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LXH13_RS15925	COG0477	Major facilitator Superfamily
LXH13_RS15930	COG1309	transcriptional regulator
LXH13_RS15940	COG1331	Highly conserved protein containing a thioredoxin domain
LXH13_RS15960	COG2814	Major facilitator Superfamily
LXH13_RS15970	COG1136	(ABC) transporter
LXH13_RS15975	COG2197	response regulator
LXH13_RS15980	COG4585	Histidine kinase
LXH13_RS15985	COG1309	transcriptional regulator
LXH13_RS15995	COG2255	four-way junction helicase activity
LXH13_RS16005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXH13_RS16015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LXH13_RS16030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LXH13_RS16035	COG2255	four-way junction helicase activity
LXH13_RS16040	COG1595	DNA-templated transcription, initiation
LXH13_RS16060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LXH13_RS16075	COG2197	response regulator
LXH13_RS16080	COG4585	Histidine kinase
LXH13_RS16100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS16105	COG1064	alcohol dehydrogenase
LXH13_RS16115	COG1404	Belongs to the peptidase S8 family
LXH13_RS16120	COG1136	(ABC) transporter
LXH13_RS16145	COG2986	histidine ammonia-lyase
LXH13_RS16155	COG1024	Enoyl-CoA hydratase
LXH13_RS16165	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS16170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LXH13_RS16170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LXH13_RS16175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXH13_RS16185	COG0424	maF-like protein
LXH13_RS16195	COG4770	biotin carboxylase activity
LXH13_RS16230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LXH13_RS16245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LXH13_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS16270	COG1595	DNA-templated transcription, initiation
LXH13_RS16275	COG0745	RESPONSE REGULATOR receiver
LXH13_RS16280	COG2205	protein histidine kinase activity
LXH13_RS16305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LXH13_RS16315	COG0583	DNA-binding transcription factor activity
LXH13_RS16320	COG2814	Major facilitator Superfamily
LXH13_RS16355	COG1079	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS16360	COG4603	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS16365	COG3845	ABC transporter
LXH13_RS16370	COG1744	ABC transporter substrate-binding protein PnrA-like
LXH13_RS16375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LXH13_RS16375	COG1473	amidohydrolase
LXH13_RS16385	COG2089	acid synthase
LXH13_RS16400	COG1216	Glycosyl transferase, family 2
LXH13_RS16425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS16425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS16440	COG1595	DNA-templated transcription, initiation
LXH13_RS16465	COG2205	protein histidine kinase activity
LXH13_RS16520	COG0726	polysaccharide deacetylase
LXH13_RS16530	COG0671	phosphoesterase, PA-phosphatase related
LXH13_RS16570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LXH13_RS16580	COG2009	succinate dehydrogenase
LXH13_RS16590	COG1053	succinate dehydrogenase
LXH13_RS16615	COG1309	transcriptional regulator
LXH13_RS16620	COG2409	Drug exporters of the RND superfamily
LXH13_RS16625	COG0745	RESPONSE REGULATOR receiver
LXH13_RS16630	COG2205	protein histidine kinase activity
LXH13_RS16640	COG1408	metallophosphoesterase
LXH13_RS16650	COG1686	Belongs to the peptidase S11 family
LXH13_RS16655	COG1295	ribonuclease BN
LXH13_RS16670	COG0180	Tryptophanyl-tRNA synthetase
LXH13_RS16675	COG1595	DNA-templated transcription, initiation
LXH13_RS16695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LXH13_RS16700	COG0754	glutathionylspermidine amidase activity
LXH13_RS16715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXH13_RS16720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXH13_RS16725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXH13_RS16740	COG4176	ABC-type proline glycine betaine transport system permease component
LXH13_RS16745	COG0517	IMP dehydrogenase activity
LXH13_RS16745	COG4175	Glycine betaine
LXH13_RS16755	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS16790	COG0039	L-malate dehydrogenase activity
LXH13_RS16810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LXH13_RS16835	COG0138	bifunctional purine biosynthesis protein purh
LXH13_RS16865	COG0045	succinate-CoA ligase (ADP-forming) activity
LXH13_RS16875	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LXH13_RS16880	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LXH13_RS16885	COG0714	Associated with various cellular activities
LXH13_RS16900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS16900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS16935	COG0791	NLP P60 protein
LXH13_RS16940	COG2197	response regulator
LXH13_RS16985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LXH13_RS16985	COG0519	Catalyzes the synthesis of GMP from XMP
LXH13_RS17005	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS17010	COG0515	serine threonine protein kinase
LXH13_RS17015	COG0515	serine threonine protein kinase
LXH13_RS17020	COG0515	serine threonine protein kinase
LXH13_RS17030	COG0515	serine threonine protein kinase
LXH13_RS17035	COG0515	serine threonine protein kinase
LXH13_RS17035	COG2815	serine threonine protein kinase
LXH13_RS17040	COG2815	serine threonine protein kinase
LXH13_RS17040	COG0515	serine threonine protein kinase
LXH13_RS17050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LXH13_RS17060	COG0516	GMP reductase activity
LXH13_RS17070	COG1595	DNA-templated transcription, initiation
LXH13_RS17090	COG0583	DNA-binding transcription factor activity
LXH13_RS17100	COG4221	oxidoreductase activity
LXH13_RS17105	COG0459	protein refolding
LXH13_RS17115	COG0726	polysaccharide deacetylase
LXH13_RS17120	COG0726	polysaccharide deacetylase
LXH13_RS17130	COG4941	Belongs to the sigma-70 factor family
LXH13_RS17145	COG1609	Transcriptional regulator
LXH13_RS17150	COG1472	Belongs to the glycosyl hydrolase 3 family
LXH13_RS17165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LXH13_RS17190	COG0802	atpase or kinase
LXH13_RS17200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LXH13_RS17215	COG0736	holo-[acyl-carrier-protein] synthase activity
LXH13_RS17220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LXH13_RS17225	COG1072	(Pantothenic acid kinase))
LXH13_RS17235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LXH13_RS17240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LXH13_RS17245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LXH13_RS17255	COG0101	tRNA pseudouridine synthase activity
LXH13_RS17260	COG0203	ribosomal protein L17
LXH13_RS17265	COG0202	RNA polymerase activity
LXH13_RS17270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LXH13_RS17275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LXH13_RS17280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LXH13_RS17285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LXH13_RS17295	COG0563	adenylate kinase activity
LXH13_RS17305	COG0200	Binds to the 23S rRNA
LXH13_RS17310	COG1841	ribosomal large subunit assembly
LXH13_RS17315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LXH13_RS17320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LXH13_RS17325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LXH13_RS17330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LXH13_RS17335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LXH13_RS17340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LXH13_RS17345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LXH13_RS17350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LXH13_RS17355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LXH13_RS17360	COG0255	Belongs to the universal ribosomal protein uL29 family
LXH13_RS17365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LXH13_RS17370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LXH13_RS17375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LXH13_RS17380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LXH13_RS17385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LXH13_RS17390	COG0089	rRNA binding
LXH13_RS17395	COG0088	Forms part of the polypeptide exit tunnel
LXH13_RS17400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LXH13_RS17405	COG0051	transcription antitermination factor activity, RNA binding
LXH13_RS17410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LXH13_RS17410	COG2755	lipolytic protein G-D-S-L family
LXH13_RS17415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LXH13_RS17420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LXH13_RS17425	COG0049	tRNA binding
LXH13_RS17430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LXH13_RS17440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LXH13_RS17445	COG0085	RNA polymerase activity
LXH13_RS17450	COG0222	ribosome binding
LXH13_RS17455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LXH13_RS17470	COG0081	regulation of translation
LXH13_RS17475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LXH13_RS17495	COG0436	Aminotransferase
LXH13_RS17500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LXH13_RS17520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LXH13_RS17525	COG0477	Major facilitator Superfamily
LXH13_RS17540	COG2030	dehydratase
LXH13_RS17545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LXH13_RS17565	COG0702	epimerase
LXH13_RS17605	COG1666	GTP binding
LXH13_RS17610	COG2261	transglycosylase associated protein
LXH13_RS17625	COG3304	Inner membrane component domain
LXH13_RS17630	COG0501	Belongs to the peptidase M48B family
LXH13_RS17635	COG1007	ATP synthesis coupled electron transport
LXH13_RS17645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LXH13_RS17650	COG0713	ATP synthesis coupled electron transport
LXH13_RS17655	COG0839	Belongs to the complex I subunit 6 family
LXH13_RS17660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS17665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LXH13_RS17670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS17675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS17680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS17700	COG0674	pyruvate-flavodoxin oxidoreductase activity
LXH13_RS17700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LXH13_RS17705	COG1013	pyruvate-flavodoxin oxidoreductase activity
LXH13_RS17710	COG1733	regulation of RNA biosynthetic process
LXH13_RS17715	COG0702	epimerase
LXH13_RS17745	COG1131	(ABC) transporter
LXH13_RS17755	COG0142	geranyltranstransferase activity
LXH13_RS17765	COG0561	phosphatase activity
LXH13_RS17790	COG2188	Transcriptional regulator
LXH13_RS17820	COG0514	ATP-dependent DNA helicase (RecQ)
LXH13_RS17825	COG1007	ATP synthesis coupled electron transport
LXH13_RS17835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LXH13_RS17840	COG0713	ATP synthesis coupled electron transport
LXH13_RS17845	COG0839	Belongs to the complex I subunit 6 family
LXH13_RS17850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS17855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LXH13_RS17860	COG1034	ATP synthesis coupled electron transport
LXH13_RS17865	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LXH13_RS17875	COG0649	NAD binding
LXH13_RS17880	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS17885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS17900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LXH13_RS17900	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LXH13_RS17905	COG0242	peptide deformylase activity
LXH13_RS17925	COG2226	methyltransferase
LXH13_RS17955	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LXH13_RS18000	COG3209	COG3209 Rhs family protein
LXH13_RS18180	COG1674	ftsk spoiiie
LXH13_RS18190	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LXH13_RS18195	COG1278	Cold shock
LXH13_RS18225	COG0583	DNA-binding transcription factor activity
LXH13_RS18250	COG1309	transcriptional regulator
LXH13_RS18265	COG1573	uracil-dna glycosylase
LXH13_RS18270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LXH13_RS18280	COG0163	prenyltransferase activity
LXH13_RS18290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LXH13_RS18300	COG0640	Transcriptional regulator
LXH13_RS18305	COG0604	alcohol dehydrogenase
LXH13_RS18305	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS18305	COG3321	synthase
LXH13_RS18320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LXH13_RS18325	COG1333	cytochrome c biogenesis protein
LXH13_RS18330	COG0785	Cytochrome C biogenesis protein
LXH13_RS18335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXH13_RS18345	COG0406	alpha-ribazole phosphatase activity
LXH13_RS18350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LXH13_RS18400	COG2205	protein histidine kinase activity
LXH13_RS18415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS18425	COG0604	alcohol dehydrogenase
LXH13_RS18430	COG1733	regulation of RNA biosynthetic process
LXH13_RS18435	COG1846	Transcriptional regulator
LXH13_RS18440	COG1742	UPF0060 membrane protein
LXH13_RS18465	COG1690	Belongs to the RtcB family
LXH13_RS18485	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LXH13_RS18490	COG0018	arginyl-trna synthetase
LXH13_RS18495	COG4106	trans-aconitate 2-methyltransferase activity
LXH13_RS18520	COG0113	porphobilinogen synthase activity
LXH13_RS18535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LXH13_RS18535	COG1648	precorrin-2 dehydrogenase activity
LXH13_RS18540	COG0181	hydroxymethylbilane synthase activity
LXH13_RS18545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LXH13_RS18550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LXH13_RS18600	COG0123	including yeast histone deacetylase and acetoin utilization protein
LXH13_RS18635	COG0180	Tryptophanyl-tRNA synthetase
LXH13_RS18645	COG1335	isochorismatase
LXH13_RS18650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LXH13_RS18660	COG0842	Transport permease protein
LXH13_RS18660	COG1129	ABC transporter
LXH13_RS18680	COG0515	serine threonine protein kinase
LXH13_RS18680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LXH13_RS18685	COG0129	dihydroxy-acid dehydratase activity
LXH13_RS18695	COG1082	Xylose isomerase domain protein TIM barrel
LXH13_RS18700	COG0248	Ppx GppA phosphatase
LXH13_RS18720	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LXH13_RS18730	COG1194	a g-specific adenine glycosylase
LXH13_RS18735	COG1595	DNA-templated transcription, initiation
LXH13_RS18745	COG0745	RESPONSE REGULATOR receiver
LXH13_RS18750	COG2205	protein histidine kinase activity
LXH13_RS18755	COG0477	Major facilitator Superfamily
LXH13_RS18765	COG0739	heme binding
LXH13_RS18790	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LXH13_RS18810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LXH13_RS18820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LXH13_RS18825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LXH13_RS18835	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LXH13_RS18850	COG1660	Displays ATPase and GTPase activities
LXH13_RS18870	COG0649	NAD binding
LXH13_RS18895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LXH13_RS18895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LXH13_RS18910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LXH13_RS18925	COG0302	gtp cyclohydrolase
LXH13_RS18940	COG0037	tRNA processing
LXH13_RS18950	COG2027	D-alanyl-D-alanine carboxypeptidase
LXH13_RS18955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LXH13_RS18965	COG0586	Pfam SNARE associated Golgi protein
LXH13_RS18970	COG0789	Transcriptional regulator
LXH13_RS18980	COG0076	glutamate decarboxylase activity
LXH13_RS18990	COG2318	DinB family
LXH13_RS18995	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS19045	COG0667	Aldo Keto reductase
LXH13_RS19055	COG1280	lysine exporter protein (LysE YggA)
LXH13_RS19065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LXH13_RS19065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LXH13_RS19090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LXH13_RS19095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LXH13_RS19100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LXH13_RS19100	COG1754	DNA topoisomerase type I activity
LXH13_RS19120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LXH13_RS19125	COG2172	sigma factor antagonist activity
LXH13_RS19130	COG1366	Belongs to the anti-sigma-factor antagonist family
LXH13_RS19135	COG1205	dead DEAH box helicase
LXH13_RS19135	COG1111	helicase
LXH13_RS19210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LXH13_RS19215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LXH13_RS19225	COG0596	Alpha beta hydrolase
LXH13_RS19260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXH13_RS19270	COG0251	oxidation-reduction process
LXH13_RS19290	COG0003	Pfam Anion-transporting ATPase
LXH13_RS19300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXH13_RS19305	COG1610	YqeY-like protein
LXH13_RS19310	COG1408	metallophosphoesterase
LXH13_RS19360	COG1674	ftsk spoiiie
LXH13_RS19460	COG2319	Wd-40 repeat
LXH13_RS19460	COG4249	Peptidase C14 caspase catalytic subunit p20
LXH13_RS19475	COG0701	Predicted permease
LXH13_RS19520	COG1595	DNA-templated transcription, initiation
LXH13_RS19545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LXH13_RS19550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LXH13_RS19580	COG1802	Transcriptional regulator
LXH13_RS19585	COG0463	Glycosyl transferase, family 2
LXH13_RS19605	COG0737	Belongs to the 5'-nucleotidase family
LXH13_RS19645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LXH13_RS19665	COG1131	(ABC) transporter
LXH13_RS19670	COG3559	Exporter of polyketide antibiotics
LXH13_RS19685	COG2197	response regulator
LXH13_RS19700	COG3844	kynureninase activity
LXH13_RS19715	COG0477	Major facilitator Superfamily
LXH13_RS19720	COG0191	fructose-bisphosphate aldolase activity
LXH13_RS19725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LXH13_RS19740	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LXH13_RS19765	COG0542	response to heat
LXH13_RS19795	COG4213	ABC transporter substrate-binding protein
LXH13_RS19800	COG0789	Transcriptional regulator
LXH13_RS19805	COG0484	heat shock protein binding
LXH13_RS19810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LXH13_RS19815	COG0443	Heat shock 70 kDa protein
LXH13_RS19820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LXH13_RS19825	COG0247	lactate metabolic process
LXH13_RS19825	COG2181	nitrate reductase activity
LXH13_RS19865	COG4585	Histidine kinase
LXH13_RS19870	COG2197	response regulator
LXH13_RS19890	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LXH13_RS19895	COG0717	Belongs to the dCTP deaminase family
LXH13_RS19920	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
LXH13_RS19980	COG1252	NADH dehydrogenase
LXH13_RS19985	COG1595	DNA-templated transcription, initiation
LXH13_RS20040	COG4213	ABC transporter substrate-binding protein
LXH13_RS20080	COG1957	nucleoside hydrolase
LXH13_RS20085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LXH13_RS20095	COG0222	ribosome binding
LXH13_RS20100	COG1396	sequence-specific DNA binding
LXH13_RS20150	COG0583	DNA-binding transcription factor activity
LXH13_RS20160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LXH13_RS20170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LXH13_RS20180	COG1741	Belongs to the pirin family
LXH13_RS20190	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS20195	COG1362	aminopeptidase activity
LXH13_RS20245	COG2814	Major facilitator Superfamily
LXH13_RS20260	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXH13_RS20265	COG0022	dehydrogenase e1 component
LXH13_RS20280	COG0515	serine threonine protein kinase
LXH13_RS20285	COG0515	serine threonine protein kinase
LXH13_RS20300	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS20300	COG3321	synthase
LXH13_RS20300	COG0604	alcohol dehydrogenase
LXH13_RS20335	COG1522	sequence-specific DNA binding
LXH13_RS20340	COG1309	transcriptional regulator
LXH13_RS20345	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXH13_RS20405	COG1716	ATPase activity
LXH13_RS20410	COG1716	ATPase activity
LXH13_RS20430	COG0515	serine threonine protein kinase
LXH13_RS20440	COG3764	Sortase (surface protein transpeptidase)
LXH13_RS20445	COG3764	Sortase (surface protein transpeptidase)
LXH13_RS20460	COG3764	Sortase (surface protein transpeptidase)
LXH13_RS20475	COG0705	Rhomboid family
LXH13_RS20490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LXH13_RS20510	COG0515	serine threonine protein kinase
LXH13_RS20545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LXH13_RS20550	COG0187	DNA topoisomerase II activity
LXH13_RS20555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LXH13_RS20560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LXH13_RS20565	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LXH13_RS20570	COG0592	DNA-directed DNA polymerase activity
LXH13_RS20575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LXH13_RS20585	COG0594	ribonuclease P activity
LXH13_RS20590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LXH13_RS20595	COG0706	membrane insertase activity
LXH13_RS20605	COG0357	Ribosomal RNA small subunit methyltransferase G
LXH13_RS20610	COG1192	Involved in chromosome partitioning
LXH13_RS20625	COG3118	belongs to the thioredoxin family
LXH13_RS20630	COG0492	ferredoxin-NADP+ reductase activity
LXH13_RS20640	COG1595	DNA-templated transcription, initiation
LXH13_RS20645	COG0515	serine threonine protein kinase
LXH13_RS20645	COG2815	serine threonine protein kinase
LXH13_RS20660	COG0617	tRNA 3'-terminal CCA addition
LXH13_RS20685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXH13_RS20710	COG0360	Binds together with S18 to 16S ribosomal RNA
LXH13_RS20715	COG0629	single-stranded DNA binding
LXH13_RS20720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LXH13_RS20725	COG0359	binds to the 23S rRNA
LXH13_RS20735	COG0305	Participates in initiation and elongation during chromosome replication
LXH13_RS20770	COG0626	cystathionine gamma-synthase activity
LXH13_RS20775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LXH13_RS20780	COG1950	PFAM Membrane protein of
LXH13_RS20785	COG0662	Cupin 2, conserved barrel domain protein
LXH13_RS20810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LXH13_RS20825	COG1609	Transcriptional regulator
LXH13_RS20830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LXH13_RS20835	COG1271	oxidase subunit
LXH13_RS20840	COG1294	oxidase, subunit
LXH13_RS20845	COG4988	ABC transporter
LXH13_RS20850	COG0561	phosphatase activity
LXH13_RS20865	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LXH13_RS20870	COG0789	Transcriptional regulator
LXH13_RS20905	COG0561	phosphatase activity
LXH13_RS20910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LXH13_RS20920	COG2837	iron assimilation
LXH13_RS20935	COG1999	signal sequence binding
LXH13_RS20960	COG0006	proline dipeptidase activity
LXH13_RS20980	COG0653	protein targeting
LXH13_RS20995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXH13_RS21015	COG0367	asparagine synthase
LXH13_RS21050	COG1595	DNA-templated transcription, initiation
LXH13_RS21055	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS21110	COG0745	RESPONSE REGULATOR receiver
LXH13_RS21115	COG2205	protein histidine kinase activity
LXH13_RS21125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LXH13_RS21135	COG3467	pyridoxamine 5'-phosphate
LXH13_RS21140	COG2353	YceI-like domain
LXH13_RS21165	COG1191	sigma factor activity
LXH13_RS21170	COG1191	sigma factor activity
LXH13_RS21275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LXH13_RS21290	COG0433	COG0433 Predicted ATPase
LXH13_RS21315	COG2372	response to copper ion
LXH13_RS21315	COG1276	copper resistance
LXH13_RS21330	COG0395	ABC-type sugar transport system, permease component
LXH13_RS21340	COG0202	RNA polymerase activity
LXH13_RS21360	COG0590	tRNA wobble adenosine to inosine editing
LXH13_RS21370	COG3260	NADH ubiquinone oxidoreductase 20
LXH13_RS21380	COG0650	Formate hydrogenlyase subunit 4
LXH13_RS21400	COG3261	NADH dehydrogenase
LXH13_RS21400	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LXH13_RS21445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LXH13_RS21460	COG2188	Transcriptional regulator
LXH13_RS21570	COG0151	Belongs to the GarS family
LXH13_RS21585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LXH13_RS21595	COG2197	response regulator
LXH13_RS21600	COG3851	Histidine kinase
LXH13_RS21630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LXH13_RS21635	COG0047	phosphoribosylformylglycinamidine synthase activity
LXH13_RS21640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LXH13_RS21645	COG0477	Major facilitator Superfamily
LXH13_RS21670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LXH13_RS21680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LXH13_RS21705	COG1643	Atp-dependent helicase
LXH13_RS21745	COG0513	Belongs to the DEAD box helicase family
LXH13_RS21765	COG0741	lytic transglycosylase activity
LXH13_RS21765	COG1196	nuclear chromosome segregation
LXH13_RS21765	COG0739	heme binding
LXH13_RS21790	COG2197	response regulator
LXH13_RS21795	COG4585	Histidine kinase
LXH13_RS21805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXH13_RS21815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LXH13_RS21815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LXH13_RS21835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LXH13_RS21840	COG0579	oxidoreductase
LXH13_RS21860	COG0366	Alpha amylase catalytic
LXH13_RS21860	COG1470	cell adhesion involved in biofilm formation
LXH13_RS21870	COG1252	NADH dehydrogenase
LXH13_RS21945	COG0739	heme binding
LXH13_RS21945	COG0741	lytic transglycosylase activity
LXH13_RS21945	COG1196	nuclear chromosome segregation
LXH13_RS21950	COG0671	phosphoesterase, PA-phosphatase related
LXH13_RS21955	COG0277	FAD linked oxidase domain protein
LXH13_RS21970	COG0581	inorganic phosphate transmembrane transporter activity
LXH13_RS21975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LXH13_RS21980	COG0306	phosphate transporter
LXH13_RS21990	COG1937	Protein conserved in bacteria
LXH13_RS22005	COG0494	nUDIX hydrolase
LXH13_RS22005	COG0406	alpha-ribazole phosphatase activity
LXH13_RS22015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LXH13_RS22025	COG1131	(ABC) transporter
LXH13_RS22030	COG1725	Transcriptional regulator
LXH13_RS22060	COG0456	acetyltransferase
LXH13_RS22090	COG0745	RESPONSE REGULATOR receiver
LXH13_RS22100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXH13_RS22110	COG1609	Transcriptional regulator
LXH13_RS22115	COG0745	RESPONSE REGULATOR receiver
LXH13_RS22140	COG2897	thiosulfate sulfurtransferase activity
LXH13_RS22175	COG3485	protocatechuate 3,4-dioxygenase
LXH13_RS22185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LXH13_RS22190	COG1490	D-aminoacyl-tRNA deacylase activity
LXH13_RS22200	COG4552	Acetyltransferase involved in intracellular survival and related
LXH13_RS22210	COG2188	Transcriptional regulator
LXH13_RS22220	COG2188	Transcriptional regulator
LXH13_RS22225	COG0546	phosphoglycolate phosphatase activity
LXH13_RS22255	COG3973	AAA domain
LXH13_RS22255	COG3973	AAA domain
LXH13_RS22265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LXH13_RS22280	COG1595	DNA-templated transcription, initiation
LXH13_RS22360	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS22390	COG0588	phosphoglycerate mutase activity
LXH13_RS22405	COG5002	protein histidine kinase activity
LXH13_RS22420	COG1329	Transcriptional regulator
LXH13_RS22425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LXH13_RS22430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LXH13_RS22435	COG0215	cysteine-tRNA ligase activity
LXH13_RS22440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LXH13_RS22460	COG3842	ATPase activity
LXH13_RS22545	COG0723	plastoquinol--plastocyanin reductase activity
LXH13_RS22545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LXH13_RS22620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LXH13_RS22640	COG5001	Diguanylate cyclase
LXH13_RS22640	COG3300	MHYT domain
LXH13_RS22650	COG1105	Belongs to the carbohydrate kinase PfkB family
LXH13_RS22660	COG1940	carbohydrate kinase activity
LXH13_RS22685	COG0463	Glycosyl transferase, family 2
LXH13_RS22705	COG0459	protein refolding
LXH13_RS22715	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LXH13_RS22740	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LXH13_RS22745	COG1737	Transcriptional regulator
LXH13_RS22780	COG3973	AAA domain
LXH13_RS22790	COG1061	Type III restriction enzyme res subunit
LXH13_RS22820	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LXH13_RS22825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LXH13_RS22835	COG2814	Major facilitator Superfamily
LXH13_RS22855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LXH13_RS22865	COG2252	PERMEase
LXH13_RS22895	COG0667	Aldo Keto reductase
LXH13_RS22920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LXH13_RS22955	COG0277	FAD linked oxidase domain protein
LXH13_RS22955	COG0247	lactate metabolic process
LXH13_RS22960	COG5006	permease, DMT superfamily
LXH13_RS22995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXH13_RS23010	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS23020	COG1309	transcriptional regulator
LXH13_RS23030	COG0259	pyridoxamine-phosphate oxidase activity
LXH13_RS23045	COG4821	SIS domain
LXH13_RS23055	COG0596	Alpha beta hydrolase
LXH13_RS23055	COG2945	thiolester hydrolase activity
LXH13_RS23105	COG1595	DNA-templated transcription, initiation
LXH13_RS23120	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS23130	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS23135	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS23155	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS23185	COG2188	Transcriptional regulator
LXH13_RS23200	COG1024	Enoyl-CoA hydratase
LXH13_RS23210	COG1231	oxidoreductase activity
LXH13_RS23215	COG2072	flavoprotein involved in K transport
LXH13_RS23235	COG0259	pyridoxamine-phosphate oxidase activity
LXH13_RS23255	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS23260	COG1309	transcriptional regulator
LXH13_RS23270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LXH13_RS23270	COG0515	serine threonine protein kinase
LXH13_RS23280	COG1024	Enoyl-CoA hydratase
LXH13_RS23380	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LXH13_RS23450	COG0386	Belongs to the glutathione peroxidase family
LXH13_RS23470	COG0596	Alpha beta hydrolase
LXH13_RS23485	COG0583	DNA-binding transcription factor activity
LXH13_RS23515	COG1271	oxidase subunit
LXH13_RS23575	COG1309	transcriptional regulator
LXH13_RS23580	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS23595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXH13_RS23615	COG1309	transcriptional regulator
LXH13_RS23630	COG1414	Transcriptional regulator
LXH13_RS23650	COG1846	Transcriptional regulator
LXH13_RS23655	COG3384	dioxygenase
LXH13_RS23660	COG1247	-acetyltransferase
LXH13_RS23665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LXH13_RS23680	COG0477	Major facilitator Superfamily
LXH13_RS23685	COG1349	DNA-binding transcription factor activity
LXH13_RS23695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXH13_RS23695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXH13_RS23695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXH13_RS23710	COG3191	aminopeptidase activity
LXH13_RS23735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LXH13_RS23760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LXH13_RS23765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LXH13_RS23775	COG0315	cyclic pyranopterin monophosphate synthase activity
LXH13_RS23780	COG0521	Mo-molybdopterin cofactor biosynthetic process
LXH13_RS23780	COG0315	cyclic pyranopterin monophosphate synthase activity
LXH13_RS23785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXH13_RS23805	COG0708	Exodeoxyribonuclease III
LXH13_RS23815	COG2072	flavoprotein involved in K transport
LXH13_RS23820	COG2267	carboxylic ester hydrolase activity
LXH13_RS23825	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS23835	COG0793	Belongs to the peptidase S41A family
LXH13_RS23835	COG4946	Tricorn protease homolog
LXH13_RS23845	COG2409	Drug exporters of the RND superfamily
LXH13_RS23855	COG0442	prolyl-tRNA aminoacylation
LXH13_RS23880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS23885	COG1122	ATPase activity
LXH13_RS23895	COG0310	cobalt ion transport
LXH13_RS23915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS23940	COG0084	hydrolase, TatD family'
LXH13_RS23945	COG3583	domain protein
LXH13_RS23945	COG3584	3D domain protein
LXH13_RS23950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LXH13_RS23955	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LXH13_RS23965	COG0488	(ABC) transporter
LXH13_RS24005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LXH13_RS24015	COG2197	response regulator
LXH13_RS24025	COG4106	trans-aconitate 2-methyltransferase activity
LXH13_RS24040	COG1309	transcriptional regulator
LXH13_RS24050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LXH13_RS24065	COG0193	aminoacyl-tRNA hydrolase activity
LXH13_RS24070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LXH13_RS24075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LXH13_RS24080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LXH13_RS24095	COG4585	Histidine kinase
LXH13_RS24125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXH13_RS24135	COG2814	Major facilitator Superfamily
LXH13_RS24140	COG1136	(ABC) transporter
LXH13_RS24145	COG0577	efflux transmembrane transporter activity
LXH13_RS24205	COG2124	cytochrome p450
LXH13_RS24220	COG0148	phosphopyruvate hydratase activity
LXH13_RS24240	COG1252	NADH dehydrogenase
LXH13_RS24245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LXH13_RS24250	COG0577	efflux transmembrane transporter activity
LXH13_RS24255	COG1136	(ABC) transporter
LXH13_RS24290	COG0183	Belongs to the thiolase family
LXH13_RS24295	COG2755	lipolytic protein G-D-S-L family
LXH13_RS24315	COG1174	glycine betaine transport
LXH13_RS24320	COG1174	glycine betaine transport
LXH13_RS24330	COG2986	histidine ammonia-lyase
LXH13_RS24360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LXH13_RS24370	COG1228	amidohydrolase
LXH13_RS24375	COG1191	sigma factor activity
LXH13_RS24380	COG1366	Belongs to the anti-sigma-factor antagonist family
LXH13_RS24410	COG3104	oligopeptide transport
LXH13_RS24415	COG0745	RESPONSE REGULATOR receiver
LXH13_RS24420	COG2205	protein histidine kinase activity
LXH13_RS24475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LXH13_RS24500	COG1316	TRANSCRIPTIONal
LXH13_RS24505	COG1607	acyl-coa hydrolase
LXH13_RS24510	COG1316	TRANSCRIPTIONal
LXH13_RS24520	COG1316	TRANSCRIPTIONal
LXH13_RS24525	COG1316	TRANSCRIPTIONal
LXH13_RS24530	COG1316	TRANSCRIPTIONal
LXH13_RS24535	COG1316	TRANSCRIPTIONal
LXH13_RS24560	COG0778	Nitroreductase
LXH13_RS24560	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LXH13_RS24565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LXH13_RS24600	COG1620	l-lactate permease
LXH13_RS24605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LXH13_RS24610	COG2835	tetraacyldisaccharide 4'-kinase activity
LXH13_RS24620	COG1482	cell wall glycoprotein biosynthetic process
LXH13_RS24630	COG0681	Belongs to the peptidase S26 family
LXH13_RS24635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LXH13_RS24675	COG0714	Associated with various cellular activities
LXH13_RS24695	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LXH13_RS24700	COG0745	RESPONSE REGULATOR receiver
LXH13_RS24705	COG5002	protein histidine kinase activity
LXH13_RS24710	COG0823	Involved in the tonB-independent uptake of proteins
LXH13_RS24720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LXH13_RS24725	COG2197	response regulator
LXH13_RS24730	COG3214	Protein conserved in bacteria
LXH13_RS24740	COG0653	protein targeting
LXH13_RS24765	COG2902	Dehydrogenase
LXH13_RS24770	COG1134	teichoic acid transport
LXH13_RS24800	COG1846	Transcriptional regulator
LXH13_RS24805	COG1764	response to oxidative stress
LXH13_RS24810	COG1216	Glycosyl transferase, family 2
LXH13_RS24815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LXH13_RS24820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LXH13_RS24825	COG0395	ABC-type sugar transport system, permease component
LXH13_RS24830	COG1175	transmembrane transport
LXH13_RS24835	COG1653	transport
LXH13_RS24845	COG0515	serine threonine protein kinase
LXH13_RS24850	COG0515	serine threonine protein kinase
LXH13_RS24855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LXH13_RS24870	COG2884	Cell division ATP-binding protein ftsE
LXH13_RS24880	COG0793	Belongs to the peptidase S41A family
LXH13_RS24885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LXH13_RS24900	COG1501	Belongs to the glycosyl hydrolase 31 family
LXH13_RS24905	COG0395	ABC-type sugar transport system, permease component
LXH13_RS24910	COG1175	transmembrane transport
LXH13_RS24960	COG2223	nitrite transmembrane transporter activity
LXH13_RS24990	COG3973	AAA domain
LXH13_RS25000	COG0776	regulation of translation
LXH13_RS25005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LXH13_RS25010	COG1678	Uncharacterized ACR, COG1678
LXH13_RS25030	COG0395	ABC-type sugar transport system, permease component
LXH13_RS25035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LXH13_RS25085	COG1174	glycine betaine transport
LXH13_RS25090	COG1125	glycine betaine transport
LXH13_RS25090	COG0517	IMP dehydrogenase activity
LXH13_RS25095	COG1174	glycine betaine transport
LXH13_RS25105	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LXH13_RS25115	COG0277	FAD linked oxidase domain protein
LXH13_RS25150	COG1335	isochorismatase
LXH13_RS25160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LXH13_RS25170	COG1113	amino acid transport
LXH13_RS25200	COG1263	PTS System
LXH13_RS25205	COG1263	PTS System
LXH13_RS25210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXH13_RS25215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LXH13_RS25225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LXH13_RS25260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXH13_RS25275	COG4555	ABC transporter
LXH13_RS25290	COG2733	membrane
LXH13_RS25295	COG2271	Major facilitator Superfamily
LXH13_RS25300	COG0596	Alpha beta hydrolase
LXH13_RS25405	COG3764	Sortase (surface protein transpeptidase)
LXH13_RS25450	COG2894	cell division
LXH13_RS25480	COG3920	Histidine kinase
LXH13_RS25485	COG2197	response regulator
LXH13_RS25590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LXH13_RS25595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LXH13_RS25605	COG0590	tRNA wobble adenosine to inosine editing
LXH13_RS25605	COG0037	tRNA processing
LXH13_RS25615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LXH13_RS25620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LXH13_RS25640	COG1136	(ABC) transporter
LXH13_RS25660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXH13_RS25680	COG0114	fumarate hydratase activity
LXH13_RS25685	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LXH13_RS25685	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LXH13_RS25710	COG0778	Nitroreductase
LXH13_RS25715	COG1722	exodeoxyribonuclease VII activity
LXH13_RS25720	COG1570	exodeoxyribonuclease VII activity
LXH13_RS25725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LXH13_RS25740	COG0012	GTP binding
LXH13_RS25760	COG1595	DNA-templated transcription, initiation
LXH13_RS25785	COG0596	Alpha beta hydrolase
LXH13_RS25810	COG0583	DNA-binding transcription factor activity
LXH13_RS25860	COG1053	succinate dehydrogenase
LXH13_RS25880	COG1217	gtp-binding protein TYPA
LXH13_RS25885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXH13_RS25890	COG4166	transmembrane transport
LXH13_RS25895	COG0601	transmembrane transport
LXH13_RS25900	COG0444	Belongs to the ABC transporter superfamily
LXH13_RS25905	COG4608	Belongs to the ABC transporter superfamily
LXH13_RS25940	COG0346	lactoylglutathione lyase activity
LXH13_RS25955	COG4608	Belongs to the ABC transporter superfamily
LXH13_RS25960	COG0444	Belongs to the ABC transporter superfamily
LXH13_RS25965	COG0601	transmembrane transport
LXH13_RS25970	COG0747	negative chemotaxis
LXH13_RS25975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXH13_RS25985	COG0601	transmembrane transport
LXH13_RS25990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXH13_RS26000	COG4608	Belongs to the ABC transporter superfamily
LXH13_RS26035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXH13_RS26060	COG1131	(ABC) transporter
LXH13_RS26070	COG4585	Histidine kinase
LXH13_RS26075	COG2197	response regulator
LXH13_RS26110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LXH13_RS26120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LXH13_RS26130	COG2818	Glycosylase
LXH13_RS26135	COG1024	Enoyl-CoA hydratase
LXH13_RS26150	COG1595	DNA-templated transcription, initiation
LXH13_RS26160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXH13_RS26165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LXH13_RS26200	COG0598	Magnesium transport protein CorA
LXH13_RS26210	COG2814	Major facilitator Superfamily
LXH13_RS26225	COG2095	MarC family integral membrane protein
LXH13_RS26235	COG1432	Conserved Protein
LXH13_RS26245	COG0513	Belongs to the DEAD box helicase family
LXH13_RS26285	COG0747	negative chemotaxis
LXH13_RS26290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXH13_RS26295	COG0601	transmembrane transport
LXH13_RS26305	COG0297	glycogen (starch) synthase activity
LXH13_RS26365	COG2816	NAD+ diphosphatase activity
LXH13_RS26395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LXH13_RS26450	COG3480	Lon protease (S16) C-terminal proteolytic domain
LXH13_RS26460	COG1615	UPF0182 protein
LXH13_RS26505	COG0483	inositol monophosphate 1-phosphatase activity
LXH13_RS26520	COG1162	GTPase activity
LXH13_RS26525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LXH13_RS26535	COG2135	peptidase activity
LXH13_RS26545	COG1595	DNA-templated transcription, initiation
LXH13_RS26550	COG5662	AntiSigma factor
LXH13_RS26555	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LXH13_RS26555	COG2199	diguanylate cyclase activity
LXH13_RS26570	COG0242	peptide deformylase activity
LXH13_RS26575	COG4977	sequence-specific DNA binding
LXH13_RS26620	COG2188	Transcriptional regulator
LXH13_RS26625	COG2182	Extracellular solute-binding protein
LXH13_RS26630	COG1175	transmembrane transport
LXH13_RS26635	COG0395	ABC-type sugar transport system, permease component
LXH13_RS26640	COG1472	Belongs to the glycosyl hydrolase 3 family
LXH13_RS26645	COG0363	glucosamine-6-phosphate deaminase activity
LXH13_RS26660	COG1597	lipid kinase activity
LXH13_RS26685	COG0025	NhaP-type Na H and K H
LXH13_RS26690	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LXH13_RS26700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LXH13_RS26705	COG0142	geranyltranstransferase activity
LXH13_RS26760	COG4106	trans-aconitate 2-methyltransferase activity
LXH13_RS26765	COG1126	abc transporter atp-binding protein
LXH13_RS26770	COG0765	amino acid transport
LXH13_RS26780	COG0281	malic enzyme
LXH13_RS26785	COG0604	alcohol dehydrogenase
LXH13_RS26820	COG0567	Dehydrogenase, E1 component
LXH13_RS26820	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXH13_RS26825	COG2205	protein histidine kinase activity
LXH13_RS26830	COG0745	RESPONSE REGULATOR receiver
LXH13_RS26860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LXH13_RS26880	COG2205	protein histidine kinase activity
LXH13_RS26935	COG0768	penicillin binding
LXH13_RS26950	COG2205	protein histidine kinase activity
LXH13_RS26970	COG1793	dna ligase
LXH13_RS26970	COG3285	dna ligase
LXH13_RS26975	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LXH13_RS27030	COG0018	arginyl-trna synthetase
LXH13_RS27035	COG0019	diaminopimelate decarboxylase activity
LXH13_RS27040	COG0460	homoserine dehydrogenase
LXH13_RS27045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LXH13_RS27050	COG0083	homoserine kinase activity
LXH13_RS27070	COG0254	rRNA binding
LXH13_RS27075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LXH13_RS27080	COG2890	protein-(glutamine-N5) methyltransferase activity
LXH13_RS27090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LXH13_RS27095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LXH13_RS27100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LXH13_RS27115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LXH13_RS27120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LXH13_RS27125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LXH13_RS27130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LXH13_RS27135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LXH13_RS27140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LXH13_RS27145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LXH13_RS27160	COG2197	response regulator
LXH13_RS27175	COG0745	RESPONSE REGULATOR receiver
LXH13_RS27215	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXH13_RS27230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LXH13_RS27265	COG1131	(ABC) transporter
LXH13_RS27280	COG0346	lactoylglutathione lyase activity
LXH13_RS27285	COG0183	Belongs to the thiolase family
LXH13_RS27340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS27340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS27375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LXH13_RS27380	COG0857	belongs to the CobB CobQ family
LXH13_RS27380	COG0280	phosphate acetyltransferase
LXH13_RS27385	COG0205	6-phosphofructokinase activity
LXH13_RS27395	COG0395	ABC-type sugar transport system, permease component
LXH13_RS27400	COG1175	transmembrane transport
LXH13_RS27405	COG1653	transport
LXH13_RS27410	COG4565	transcriptional regulatory protein
LXH13_RS27415	COG3290	protein histidine kinase activity
LXH13_RS27420	COG1301	dicarboxylic acid transport
LXH13_RS27435	COG3118	belongs to the thioredoxin family
LXH13_RS27445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LXH13_RS27450	COG3281	Trehalose synthase
LXH13_RS27455	COG0366	Alpha amylase catalytic
LXH13_RS27460	COG0366	Alpha amylase catalytic
LXH13_RS27470	COG0058	SHG alpha-glucan phosphorylase activity
LXH13_RS27510	COG1132	(ABC) transporter
LXH13_RS27515	COG1132	(ABC) transporter
LXH13_RS27520	COG1132	(ABC) transporter
LXH13_RS27525	COG1132	(ABC) transporter
LXH13_RS27530	COG1131	(ABC) transporter
LXH13_RS27545	COG2197	response regulator
LXH13_RS27555	COG1376	ErfK ybiS ycfS ynhG family protein
LXH13_RS27560	COG1376	ErfK ybiS ycfS ynhG family protein
LXH13_RS27590	COG0789	Transcriptional regulator
LXH13_RS27610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LXH13_RS27620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LXH13_RS27645	COG0702	epimerase
LXH13_RS27650	COG1733	regulation of RNA biosynthetic process
LXH13_RS27655	COG1760	l-serine dehydratase
LXH13_RS27660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LXH13_RS27665	COG0509	glycine decarboxylation via glycine cleavage system
LXH13_RS27670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LXH13_RS27690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXH13_RS27695	COG0747	negative chemotaxis
LXH13_RS27705	COG0444	Belongs to the ABC transporter superfamily
LXH13_RS27710	COG4608	Belongs to the ABC transporter superfamily
LXH13_RS27720	COG2860	membrane
LXH13_RS27735	COG2378	regulation of single-species biofilm formation
LXH13_RS27765	COG0482	sulfurtransferase activity
LXH13_RS27780	COG1611	Belongs to the LOG family
LXH13_RS27785	COG4221	oxidoreductase activity
LXH13_RS27795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LXH13_RS27820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LXH13_RS27825	COG0154	amidase activity
LXH13_RS27835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LXH13_RS27840	COG2226	methyltransferase
LXH13_RS27850	COG2409	Drug exporters of the RND superfamily
LXH13_RS27855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXH13_RS27870	COG1672	PFAM Archaeal ATPase
LXH13_RS27870	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS27880	COG2133	pyrroloquinoline quinone binding
LXH13_RS27885	COG0667	Aldo Keto reductase
LXH13_RS27895	COG5001	Diguanylate cyclase
LXH13_RS27895	COG3300	MHYT domain
LXH13_RS27905	COG0440	acetolactate synthase activity
LXH13_RS27910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LXH13_RS27915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LXH13_RS27920	COG0477	Major facilitator Superfamily
LXH13_RS27935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXH13_RS27940	COG2508	Transcriptional regulator
LXH13_RS27945	COG0506	proline dehydrogenase activity
LXH13_RS27950	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS27960	COG0473	3-isopropylmalate dehydrogenase activity
LXH13_RS27965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LXH13_RS27985	COG0831	urea catabolic process
LXH13_RS27985	COG0832	Belongs to the urease beta subunit family
LXH13_RS27990	COG0804	urea catabolic process
LXH13_RS27995	COG2957	Belongs to the agmatine deiminase family
LXH13_RS28010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LXH13_RS28035	COG2197	response regulator
LXH13_RS28065	COG5492	domain, Protein
LXH13_RS28070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXH13_RS28090	COG2018	Roadblock/LC7 domain
LXH13_RS28110	COG2018	Roadblock/LC7 domain
LXH13_RS28115	COG5002	protein histidine kinase activity
LXH13_RS28125	COG0179	Fumarylacetoacetate (FAA) hydrolase
LXH13_RS28130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LXH13_RS28175	COG1414	Transcriptional regulator
LXH13_RS28180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LXH13_RS28185	COG0066	3-isopropylmalate dehydratase activity
LXH13_RS28195	COG0776	regulation of translation
LXH13_RS28205	COG1920	GTP binding
LXH13_RS28215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LXH13_RS28220	COG1181	Belongs to the D-alanine--D-alanine ligase family
LXH13_RS28240	COG0351	phosphomethylpyrimidine kinase
LXH13_RS28255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LXH13_RS28260	COG1461	Dihydroxyacetone kinase
LXH13_RS28270	COG0326	Molecular chaperone. Has ATPase activity
LXH13_RS28280	COG0742	ribosomal rna small subunit methyltransferase
LXH13_RS28285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LXH13_RS28300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LXH13_RS28305	COG0571	ribonuclease III activity
LXH13_RS28310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LXH13_RS28315	COG1733	regulation of RNA biosynthetic process
LXH13_RS28320	COG2340	Cysteine-rich secretory protein family
LXH13_RS28325	COG1254	Belongs to the acylphosphatase family
LXH13_RS28335	COG1196	nuclear chromosome segregation
LXH13_RS28340	COG0477	Major facilitator Superfamily
LXH13_RS28375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LXH13_RS28385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LXH13_RS28400	COG0228	four-way junction DNA binding
LXH13_RS28405	COG1837	Belongs to the UPF0109 family
LXH13_RS28410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LXH13_RS28415	COG0336	Belongs to the RNA methyltransferase TrmD family
LXH13_RS28420	COG0335	large ribosomal subunit rRNA binding
LXH13_RS28445	COG1051	belongs to the nudix hydrolase family
LXH13_RS28455	COG0792	nuclease activity
LXH13_RS28470	COG1191	sigma factor activity
LXH13_RS28480	COG4942	peptidase
LXH13_RS28485	COG0052	Belongs to the universal ribosomal protein uS2 family
LXH13_RS28490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LXH13_RS28495	COG0528	UMP kinase activity
LXH13_RS28500	COG0233	cytoplasmic translational termination
LXH13_RS28505	COG0575	Belongs to the CDS family
LXH13_RS28520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LXH13_RS28530	COG4208	sulfate ABC transporter
LXH13_RS28535	COG3842	ATPase activity
LXH13_RS28560	COG1136	(ABC) transporter
LXH13_RS28565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LXH13_RS28575	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS28585	COG0745	RESPONSE REGULATOR receiver
LXH13_RS28590	COG2205	protein histidine kinase activity
LXH13_RS28600	COG0604	alcohol dehydrogenase
LXH13_RS28600	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS28600	COG3321	synthase
LXH13_RS28605	COG2205	protein histidine kinase activity
LXH13_RS28610	COG0745	RESPONSE REGULATOR receiver
LXH13_RS28620	COG2353	YceI-like domain
LXH13_RS28650	COG0584	glycerophosphoryl diester phosphodiesterase
LXH13_RS28655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LXH13_RS28685	COG3842	ATPase activity
LXH13_RS28690	COG1176	ABC-type spermidine putrescine transport system, permease component I
LXH13_RS28695	COG1177	transmembrane transport
LXH13_RS28700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LXH13_RS28735	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS28750	COG4209	transmembrane transport
LXH13_RS28755	COG0395	ABC-type sugar transport system, permease component
LXH13_RS28770	COG1605	Chorismate mutase
LXH13_RS28790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LXH13_RS28795	COG0750	zinc metalloprotease
LXH13_RS28800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LXH13_RS28805	COG1609	Transcriptional regulator
LXH13_RS28815	COG3842	ATPase activity
LXH13_RS28820	COG1176	ABC-type spermidine putrescine transport system, permease component I
LXH13_RS28840	COG0442	prolyl-tRNA aminoacylation
LXH13_RS28860	COG0779	Required for maturation of 30S ribosomal subunits
LXH13_RS28875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LXH13_RS28885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LXH13_RS28890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LXH13_RS28905	COG0455	bacterial-type flagellum organization
LXH13_RS28920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LXH13_RS28925	COG1185	polyribonucleotide nucleotidyltransferase activity
LXH13_RS28930	COG0612	Peptidase, M16
LXH13_RS28935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LXH13_RS28955	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LXH13_RS28960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS28965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LXH13_RS28995	COG2208	phosphoserine phosphatase activity
LXH13_RS28995	COG2770	Histidine kinase
LXH13_RS29000	COG4999	Histidine kinase
LXH13_RS29000	COG3437	response regulator, receiver
LXH13_RS29000	COG2205	protein histidine kinase activity
LXH13_RS29000	COG3850	Histidine kinase
LXH13_RS29010	COG1674	ftsk spoiiie
LXH13_RS29020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LXH13_RS29030	COG1058	Belongs to the CinA family
LXH13_RS29030	COG1546	Belongs to the CinA family
LXH13_RS29035	COG1396	sequence-specific DNA binding
LXH13_RS29045	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS29050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LXH13_RS29055	COG1201	RNA secondary structure unwinding
LXH13_RS29060	COG1917	Cupin 2, conserved barrel domain protein
LXH13_RS29060	COG2207	Transcriptional regulator
LXH13_RS29085	COG0628	permease
LXH13_RS29095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LXH13_RS29105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LXH13_RS29115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LXH13_RS29120	COG0765	amino acid transport
LXH13_RS29125	COG0765	amino acid transport
LXH13_RS29130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXH13_RS29135	COG1126	abc transporter atp-binding protein
LXH13_RS29140	COG0745	RESPONSE REGULATOR receiver
LXH13_RS29145	COG2205	protein histidine kinase activity
LXH13_RS29160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LXH13_RS29180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LXH13_RS29190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LXH13_RS29195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LXH13_RS29205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LXH13_RS29240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LXH13_RS29245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LXH13_RS29250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LXH13_RS29265	COG0588	phosphoglycerate mutase activity
LXH13_RS29285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LXH13_RS29300	COG0514	ATP-dependent DNA helicase (RecQ)
LXH13_RS29320	COG1121	(ABC) transporter
LXH13_RS29325	COG1802	Transcriptional regulator
LXH13_RS29330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LXH13_RS29345	COG0187	DNA topoisomerase II activity
LXH13_RS29360	COG2197	response regulator
LXH13_RS29370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXH13_RS29385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXH13_RS29395	COG4565	transcriptional regulatory protein
LXH13_RS29400	COG3290	protein histidine kinase activity
LXH13_RS29415	COG0372	Belongs to the citrate synthase family
LXH13_RS29435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LXH13_RS29440	COG0612	Peptidase, M16
LXH13_RS29455	COG1802	Transcriptional regulator
LXH13_RS29460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXH13_RS29480	COG1435	thymidine kinase activity
LXH13_RS29510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LXH13_RS29515	COG0483	inositol monophosphate 1-phosphatase activity
LXH13_RS29525	COG0745	RESPONSE REGULATOR receiver
LXH13_RS29530	COG2205	protein histidine kinase activity
LXH13_RS29555	COG0756	dUTP diphosphatase activity
LXH13_RS29570	COG1136	(ABC) transporter
LXH13_RS29570	COG4591	ABC-type transport system involved in lipoprotein release permease component
LXH13_RS29600	COG0569	domain protein
LXH13_RS29605	COG0531	amino acid
LXH13_RS29610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LXH13_RS29660	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS29675	COG3321	synthase
LXH13_RS29675	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS29675	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS29675	COG0300	oxidoreductase activity
LXH13_RS29675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LXH13_RS29700	COG3958	Transketolase
LXH13_RS29705	COG3959	Transketolase, thiamine diphosphate binding domain
LXH13_RS29730	COG0189	ligase activity
LXH13_RS29735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LXH13_RS29740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LXH13_RS29745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LXH13_RS29750	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS29755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LXH13_RS29770	COG0596	Alpha beta hydrolase
LXH13_RS29795	COG2271	Major facilitator Superfamily
LXH13_RS29800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS29805	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS29905	COG0247	lactate metabolic process
LXH13_RS29905	COG0277	FAD linked oxidase domain protein
LXH13_RS29915	COG2353	YceI-like domain
LXH13_RS29925	COG1799	cell septum assembly
LXH13_RS29955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LXH13_RS29970	COG2235	arginine
LXH13_RS29975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LXH13_RS29985	COG1024	Enoyl-CoA hydratase
LXH13_RS29995	COG0529	Catalyzes the synthesis of activated sulfate
LXH13_RS30055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LXH13_RS30060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LXH13_RS30070	COG1653	transport
LXH13_RS30075	COG1175	transmembrane transport
LXH13_RS30080	COG0395	ABC-type sugar transport system, permease component
LXH13_RS30085	COG1940	carbohydrate kinase activity
LXH13_RS30090	COG4213	ABC transporter substrate-binding protein
LXH13_RS30100	COG4214	carbohydrate transport
LXH13_RS30105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LXH13_RS30110	COG0531	amino acid
LXH13_RS30135	COG1316	TRANSCRIPTIONal
LXH13_RS30140	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS30145	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS30150	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS30155	COG0438	transferase activity, transferring glycosyl groups
LXH13_RS30165	COG1024	Enoyl-CoA hydratase
LXH13_RS30165	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXH13_RS30170	COG0183	Belongs to the thiolase family
LXH13_RS30175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LXH13_RS30190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LXH13_RS30205	COG0446	pyridine nucleotide-disulphide oxidoreductase
LXH13_RS30220	COG3253	May function as heme-dependent peroxidase
LXH13_RS30240	COG3220	belongs to the UPF0276 family
LXH13_RS30250	COG3842	ATPase activity
LXH13_RS30270	COG2326	polyphosphate kinase activity
LXH13_RS30275	COG1881	PFAM PEBP family protein
LXH13_RS30280	COG0330	HflC and HflK could
LXH13_RS30300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LXH13_RS30305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LXH13_RS30315	COG2226	methyltransferase
LXH13_RS30325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LXH13_RS30325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LXH13_RS30365	COG0745	RESPONSE REGULATOR receiver
LXH13_RS30370	COG5002	protein histidine kinase activity
LXH13_RS30380	COG2205	protein histidine kinase activity
LXH13_RS30385	COG0745	RESPONSE REGULATOR receiver
LXH13_RS30400	COG1174	glycine betaine transport
LXH13_RS30405	COG1174	glycine betaine transport
LXH13_RS30420	COG2018	Roadblock/LC7 domain
LXH13_RS30425	COG5002	protein histidine kinase activity
LXH13_RS30435	COG1940	carbohydrate kinase activity
LXH13_RS30435	COG1846	Transcriptional regulator
LXH13_RS30485	COG0642	Histidine kinase
LXH13_RS30525	COG1309	transcriptional regulator
LXH13_RS30555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXH13_RS30560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LXH13_RS30600	COG0443	Heat shock 70 kDa protein
LXH13_RS30605	COG0443	Heat shock 70 kDa protein
LXH13_RS30610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LXH13_RS30650	COG1280	lysine exporter protein (LysE YggA)
LXH13_RS30660	COG3173	Aminoglycoside phosphotransferase
LXH13_RS30690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LXH13_RS30695	COG0583	DNA-binding transcription factor activity
LXH13_RS30740	COG0583	DNA-binding transcription factor activity
LXH13_RS30765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LXH13_RS30775	COG2409	Drug exporters of the RND superfamily
LXH13_RS30785	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LXH13_RS30795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LXH13_RS30835	COG0529	Catalyzes the synthesis of activated sulfate
LXH13_RS30840	COG0175	sulfate reduction
LXH13_RS30870	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS30875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LXH13_RS30880	COG2423	ornithine cyclodeaminase activity
LXH13_RS30885	COG2175	clavaminate synthase activity
LXH13_RS30910	COG4977	sequence-specific DNA binding
LXH13_RS30910	COG1917	Cupin 2, conserved barrel domain protein
LXH13_RS30930	COG2040	homocysteine
LXH13_RS30965	COG0596	Alpha beta hydrolase
LXH13_RS30995	COG0395	ABC-type sugar transport system, permease component
LXH13_RS31000	COG1175	transmembrane transport
LXH13_RS31015	COG0277	FAD linked oxidase domain protein
LXH13_RS31035	COG1162	GTPase activity
LXH13_RS31045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LXH13_RS31070	COG0028	Belongs to the TPP enzyme family
LXH13_RS31095	COG1802	Transcriptional regulator
LXH13_RS31110	COG3835	regulator
LXH13_RS31125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LXH13_RS31130	COG2252	PERMEase
LXH13_RS31155	COG0583	DNA-binding transcription factor activity
LXH13_RS31170	COG2197	response regulator
LXH13_RS31175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LXH13_RS31180	COG0318	PFAM AMP-dependent synthetase and ligase
LXH13_RS31190	COG3960	tartronate-semialdehyde synthase activity
LXH13_RS31205	COG0753	catalase activity
LXH13_RS31210	COG2084	Dehydrogenase
LXH13_RS31215	COG3622	Belongs to the hyi family
LXH13_RS31235	COG2351	hydroxyisourate hydrolase activity
LXH13_RS31250	COG2233	PERMEase
LXH13_RS31275	COG1733	regulation of RNA biosynthetic process
LXH13_RS31290	COG0406	alpha-ribazole phosphatase activity
LXH13_RS31295	COG0436	Aminotransferase
LXH13_RS31300	COG1733	regulation of RNA biosynthetic process
LXH13_RS31315	COG4264	IucA IucC family
LXH13_RS31330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LXH13_RS31345	COG1414	Transcriptional regulator
LXH13_RS31350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LXH13_RS31355	COG4266	Belongs to the allantoicase family
LXH13_RS31360	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS31385	COG2197	response regulator
LXH13_RS31395	COG0673	inositol 2-dehydrogenase activity
LXH13_RS31400	COG2188	Transcriptional regulator
LXH13_RS31405	COG1940	carbohydrate kinase activity
LXH13_RS31415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LXH13_RS31440	COG0515	serine threonine protein kinase
LXH13_RS31440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LXH13_RS31445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXH13_RS31450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LXH13_RS31475	COG0405	Gamma-glutamyltransferase
LXH13_RS31480	COG0542	response to heat
LXH13_RS31505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LXH13_RS31520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LXH13_RS31530	COG1953	Uracil, thiamine, allantoin
LXH13_RS31545	COG3851	Histidine kinase
LXH13_RS31550	COG2197	response regulator
LXH13_RS31560	COG0483	inositol monophosphate 1-phosphatase activity
LXH13_RS31570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LXH13_RS31580	COG1595	DNA-templated transcription, initiation
LXH13_RS31590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXH13_RS31595	COG0586	Pfam SNARE associated Golgi protein
LXH13_RS31605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LXH13_RS31615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LXH13_RS31635	COG1929	Belongs to the glycerate kinase type-1 family
LXH13_RS31655	COG0559	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS31675	COG0688	phosphatidylethanolamine metabolic process
LXH13_RS31695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS31695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LXH13_RS31710	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXH13_RS31755	COG2226	methyltransferase
LXH13_RS31760	COG2362	D-Aminopeptidase
LXH13_RS31765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LXH13_RS31775	COG1619	proteins homologs of microcin C7 resistance protein MccF
LXH13_RS31810	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS31815	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS31820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS31835	COG3285	dna ligase
LXH13_RS31835	COG1793	dna ligase
LXH13_RS31890	COG2226	methyltransferase
LXH13_RS31900	COG0406	alpha-ribazole phosphatase activity
LXH13_RS31905	COG0488	(ABC) transporter
LXH13_RS31915	COG0693	protein deglycase activity
LXH13_RS31935	COG0028	Belongs to the TPP enzyme family
LXH13_RS31995	COG0443	Heat shock 70 kDa protein
LXH13_RS32020	COG2154	pterin-4-alpha-carbinolamine dehydratase
LXH13_RS32025	COG2226	methyltransferase
LXH13_RS32040	COG2378	regulation of single-species biofilm formation
LXH13_RS32065	COG2319	Wd-40 repeat
LXH13_RS32065	COG4249	Peptidase C14 caspase catalytic subunit p20
LXH13_RS32070	COG4221	oxidoreductase activity
LXH13_RS32080	COG0656	L-ascorbic acid biosynthetic process
LXH13_RS32100	COG0583	DNA-binding transcription factor activity
LXH13_RS32120	COG1063	alcohol dehydrogenase
LXH13_RS32130	COG1335	isochorismatase
LXH13_RS32135	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS32145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LXH13_RS32160	COG3383	formate dehydrogenase (NAD+) activity
LXH13_RS32165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LXH13_RS32175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LXH13_RS32185	COG1940	carbohydrate kinase activity
LXH13_RS32190	COG1129	ABC transporter
LXH13_RS32195	COG1172	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS32205	COG0673	inositol 2-dehydrogenase activity
LXH13_RS32245	COG0084	hydrolase, TatD family'
LXH13_RS32280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXH13_RS32290	COG0045	succinate-CoA ligase (ADP-forming) activity
LXH13_RS32300	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS32315	COG3594	Acyltransferase
LXH13_RS32325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LXH13_RS32335	COG2182	Extracellular solute-binding protein
LXH13_RS32340	COG1175	transmembrane transport
LXH13_RS32345	COG0395	ABC-type sugar transport system, permease component
LXH13_RS32350	COG2723	6-phospho-beta-galactosidase activity
LXH13_RS32415	COG3903	Transcriptional regulator
LXH13_RS32415	COG3629	intracellular signal transduction
LXH13_RS32475	COG1201	RNA secondary structure unwinding
LXH13_RS32520	COG0297	glycogen (starch) synthase activity
LXH13_RS32540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXH13_RS32550	COG3467	pyridoxamine 5'-phosphate
LXH13_RS32555	COG1501	Belongs to the glycosyl hydrolase 31 family
LXH13_RS32560	COG0346	lactoylglutathione lyase activity
LXH13_RS32565	COG0477	Major facilitator Superfamily
LXH13_RS32575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LXH13_RS32580	COG1082	Xylose isomerase domain protein TIM barrel
LXH13_RS32580	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LXH13_RS32595	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LXH13_RS32600	COG0166	Belongs to the GPI family
LXH13_RS32615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LXH13_RS32645	COG2409	Drug exporters of the RND superfamily
LXH13_RS32650	COG2197	response regulator
LXH13_RS32655	COG4585	Histidine kinase
LXH13_RS32670	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS32695	COG1486	melibiose metabolic process
LXH13_RS32705	COG3469	chitinase activity
LXH13_RS32715	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LXH13_RS32755	COG3842	ATPase activity
LXH13_RS32760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LXH13_RS32765	COG1176	ABC-type spermidine putrescine transport system, permease component I
LXH13_RS32770	COG1177	transmembrane transport
LXH13_RS32775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LXH13_RS32785	COG0446	pyridine nucleotide-disulphide oxidoreductase
LXH13_RS32790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXH13_RS32795	COG3938	Belongs to the proline racemase family
LXH13_RS32800	COG1802	Transcriptional regulator
LXH13_RS32815	COG1175	transmembrane transport
LXH13_RS32820	COG0395	ABC-type sugar transport system, permease component
LXH13_RS32825	COG0366	Alpha amylase catalytic
LXH13_RS32835	COG2346	COG2346, Truncated hemoglobins
LXH13_RS32845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXH13_RS32850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXH13_RS32860	COG1414	Transcriptional regulator
LXH13_RS32885	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LXH13_RS32940	COG0477	Major facilitator Superfamily
LXH13_RS32945	COG3511	phospholipase C
LXH13_RS32975	COG1672	PFAM Archaeal ATPase
LXH13_RS32975	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS32985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXH13_RS32990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LXH13_RS32995	COG3485	protocatechuate 3,4-dioxygenase
LXH13_RS33000	COG3485	protocatechuate 3,4-dioxygenase
LXH13_RS33005	COG0183	Belongs to the thiolase family
LXH13_RS33035	COG1793	dna ligase
LXH13_RS33125	COG1834	amidinotransferase
LXH13_RS33130	COG0488	(ABC) transporter
LXH13_RS33140	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LXH13_RS33165	COG1515	deoxyribonuclease V activity
LXH13_RS33180	COG3268	Saccharopine dehydrogenase
LXH13_RS33190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXH13_RS33195	COG1960	acyl-CoA dehydrogenase activity
LXH13_RS33200	COG0183	Belongs to the thiolase family
LXH13_RS33205	COG1024	Enoyl-CoA hydratase
LXH13_RS33205	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXH13_RS33215	COG1113	amino acid transport
LXH13_RS33225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXH13_RS33235	COG2936	dipeptidyl-peptidase activity
LXH13_RS33245	COG0488	(ABC) transporter
LXH13_RS33250	COG2183	response to ionizing radiation
LXH13_RS33260	COG4977	sequence-specific DNA binding
LXH13_RS33270	COG1024	Enoyl-CoA hydratase
LXH13_RS33280	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LXH13_RS33320	COG1134	teichoic acid transport
LXH13_RS33320	COG1388	LysM domain
LXH13_RS33325	COG1562	ergosterol biosynthetic process
LXH13_RS33335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LXH13_RS33345	COG1657	PFAM Prenyltransferase squalene oxidase
LXH13_RS33360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LXH13_RS33365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LXH13_RS33390	COG2365	Tyrosine phosphatase family
LXH13_RS33395	COG0739	heme binding
LXH13_RS33400	COG2755	lipolytic protein G-D-S-L family
LXH13_RS33440	COG2124	cytochrome p450
LXH13_RS33520	COG2205	protein histidine kinase activity
LXH13_RS33525	COG0745	RESPONSE REGULATOR receiver
LXH13_RS33550	COG1063	alcohol dehydrogenase
LXH13_RS33555	COG0156	8-amino-7-oxononanoate synthase activity
LXH13_RS33560	COG0583	DNA-binding transcription factor activity
LXH13_RS33600	COG0395	ABC-type sugar transport system, permease component
LXH13_RS33645	COG0477	Major facilitator Superfamily
LXH13_RS33650	COG2814	Major facilitator Superfamily
LXH13_RS33685	COG2268	Band 7 protein
LXH13_RS33720	COG0494	nUDIX hydrolase
LXH13_RS33755	COG0174	glutamine synthetase
LXH13_RS33770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LXH13_RS33780	COG0561	phosphatase activity
LXH13_RS33785	COG1396	sequence-specific DNA binding
LXH13_RS33790	COG0006	proline dipeptidase activity
LXH13_RS33795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LXH13_RS33800	COG0022	dehydrogenase e1 component
LXH13_RS33805	COG0402	S-adenosylhomocysteine deaminase activity
LXH13_RS33810	COG1917	Cupin 2, conserved barrel domain protein
LXH13_RS33815	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS33835	COG2267	carboxylic ester hydrolase activity
LXH13_RS33845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LXH13_RS33850	COG0254	rRNA binding
LXH13_RS33885	COG1132	(ABC) transporter
LXH13_RS33895	COG1595	DNA-templated transcription, initiation
LXH13_RS33900	COG2188	Transcriptional regulator
LXH13_RS33910	COG3962	Belongs to the TPP enzyme family
LXH13_RS33915	COG3718	enzyme involved in inositol metabolism
LXH13_RS33940	COG0673	inositol 2-dehydrogenase activity
LXH13_RS33950	COG0673	inositol 2-dehydrogenase activity
LXH13_RS33960	COG0673	inositol 2-dehydrogenase activity
LXH13_RS33965	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS33975	COG1609	Transcriptional regulator
LXH13_RS33985	COG0673	inositol 2-dehydrogenase activity
LXH13_RS33990	COG1609	Transcriptional regulator
LXH13_RS34005	COG3485	protocatechuate 3,4-dioxygenase
LXH13_RS34010	COG1454	alcohol dehydrogenase
LXH13_RS34020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXH13_RS34025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LXH13_RS34030	COG2828	Protein conserved in bacteria
LXH13_RS34040	COG2814	Major facilitator Superfamily
LXH13_RS34055	COG4585	Histidine kinase
LXH13_RS34060	COG2197	response regulator
LXH13_RS34070	COG0477	Major facilitator Superfamily
LXH13_RS34095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LXH13_RS34105	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS34110	COG0179	Fumarylacetoacetate (FAA) hydrolase
LXH13_RS34135	COG2197	response regulator
LXH13_RS34165	COG2124	cytochrome p450
LXH13_RS34175	COG2838	Isocitrate dehydrogenase
LXH13_RS34180	COG0668	transmembrane transport
LXH13_RS34185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LXH13_RS34195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LXH13_RS34200	COG1024	Enoyl-CoA hydratase
LXH13_RS34205	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS34215	COG1132	(ABC) transporter
LXH13_RS34220	COG0477	Major facilitator Superfamily
LXH13_RS34230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LXH13_RS34235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LXH13_RS34245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LXH13_RS34265	COG0297	glycogen (starch) synthase activity
LXH13_RS34270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LXH13_RS34275	COG3537	Alpha-1,2-mannosidase
LXH13_RS34295	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS34305	COG3842	ATPase activity
LXH13_RS34340	COG0586	Pfam SNARE associated Golgi protein
LXH13_RS34345	COG1012	belongs to the aldehyde dehydrogenase family
LXH13_RS34345	COG2030	dehydratase
LXH13_RS34365	COG2207	Transcriptional regulator
LXH13_RS34370	COG0667	Aldo Keto reductase
LXH13_RS34375	COG1191	sigma factor activity
LXH13_RS34380	COG1295	ribonuclease BN
LXH13_RS34385	COG1609	Transcriptional regulator
LXH13_RS34395	COG1175	transmembrane transport
LXH13_RS34400	COG0395	ABC-type sugar transport system, permease component
LXH13_RS34415	COG2186	Transcriptional regulator
LXH13_RS34420	COG1879	ABC-type sugar transport system periplasmic component
LXH13_RS34425	COG1129	ABC transporter
LXH13_RS34435	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS34440	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS34455	COG3618	amidohydrolase
LXH13_RS34470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LXH13_RS34495	COG0531	amino acid
LXH13_RS34510	COG0726	polysaccharide deacetylase
LXH13_RS34555	COG2814	Major facilitator Superfamily
LXH13_RS34565	COG0583	DNA-binding transcription factor activity
LXH13_RS34575	COG1053	succinate dehydrogenase
LXH13_RS34580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LXH13_RS34600	COG1234	tRNA 3'-trailer cleavage
LXH13_RS34605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LXH13_RS34610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LXH13_RS34620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LXH13_RS34620	COG0515	serine threonine protein kinase
LXH13_RS34635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS34660	COG2182	Extracellular solute-binding protein
LXH13_RS34665	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LXH13_RS34670	COG0121	glutamine amidotransferase
LXH13_RS34675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LXH13_RS34680	COG3572	ergothioneine biosynthetic process
LXH13_RS34725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LXH13_RS34735	COG1181	Belongs to the D-alanine--D-alanine ligase family
LXH13_RS34740	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LXH13_RS34770	COG0673	inositol 2-dehydrogenase activity
LXH13_RS34775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LXH13_RS34780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LXH13_RS34820	COG1215	transferase activity, transferring glycosyl groups
LXH13_RS34890	COG0477	Major facilitator Superfamily
LXH13_RS34915	COG2271	Major facilitator Superfamily
LXH13_RS34925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LXH13_RS34930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXH13_RS34975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXH13_RS34985	COG1053	succinate dehydrogenase
LXH13_RS34990	COG1595	DNA-templated transcription, initiation
LXH13_RS35060	COG1131	(ABC) transporter
LXH13_RS35070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXH13_RS35075	COG1595	DNA-templated transcription, initiation
LXH13_RS35085	COG1309	transcriptional regulator
LXH13_RS35090	COG3973	AAA domain
LXH13_RS35095	COG0667	Aldo Keto reductase
LXH13_RS35105	COG0587	DNA-directed DNA polymerase activity
LXH13_RS35125	COG0596	Alpha beta hydrolase
LXH13_RS35155	COG0583	DNA-binding transcription factor activity
LXH13_RS35180	COG0583	DNA-binding transcription factor activity
LXH13_RS35190	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS35195	COG2267	carboxylic ester hydrolase activity
LXH13_RS35210	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS35230	COG0137	argininosuccinate synthase activity
LXH13_RS35285	COG1609	Transcriptional regulator
LXH13_RS35305	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS35310	COG0667	Aldo Keto reductase
LXH13_RS35320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXH13_RS35325	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LXH13_RS35340	COG0656	L-ascorbic acid biosynthetic process
LXH13_RS35345	COG2814	Major facilitator Superfamily
LXH13_RS35395	COG1609	Transcriptional regulator
LXH13_RS35415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXH13_RS35425	COG0242	peptide deformylase activity
LXH13_RS35455	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS35490	COG0542	response to heat
LXH13_RS35505	COG1136	(ABC) transporter
LXH13_RS35510	COG1174	glycine betaine transport
LXH13_RS35515	COG1174	glycine betaine transport
LXH13_RS35530	COG0517	IMP dehydrogenase activity
LXH13_RS35530	COG1125	glycine betaine transport
LXH13_RS35535	COG3250	beta-galactosidase activity
LXH13_RS35540	COG1556	Lactate utilization protein
LXH13_RS35545	COG1139	Iron-sulfur cluster binding protein
LXH13_RS35550	COG0247	lactate metabolic process
LXH13_RS35555	COG1070	Carbohydrate kinase
LXH13_RS35560	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS35560	COG3347	Dehydrogenase
LXH13_RS35570	COG1129	ABC transporter
LXH13_RS35575	COG1172	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS35585	COG1879	ABC-type sugar transport system periplasmic component
LXH13_RS35600	COG1609	Transcriptional regulator
LXH13_RS35620	COG1357	PFAM Pentapeptide repeats (8 copies)
LXH13_RS35630	COG1309	transcriptional regulator
LXH13_RS35640	COG2706	6-phosphogluconolactonase activity
LXH13_RS35670	COG0366	Alpha amylase catalytic
LXH13_RS35675	COG1609	Transcriptional regulator
LXH13_RS35720	COG1796	DNA polymerase
LXH13_RS35720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LXH13_RS35755	COG1006	Multisubunit Na H antiporter MnhC subunit
LXH13_RS35760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LXH13_RS35775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LXH13_RS35835	COG0435	Glutathione S-transferase
LXH13_RS35860	COG2124	cytochrome p450
LXH13_RS35885	COG1486	melibiose metabolic process
LXH13_RS35895	COG0395	ABC-type sugar transport system, permease component
LXH13_RS35900	COG1175	transmembrane transport
LXH13_RS35905	COG1653	transport
LXH13_RS35915	COG0667	Aldo Keto reductase
LXH13_RS35950	COG1595	DNA-templated transcription, initiation
LXH13_RS35960	COG3250	beta-galactosidase activity
LXH13_RS35970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXH13_RS35990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LXH13_RS36010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LXH13_RS36035	COG2890	protein-(glutamine-N5) methyltransferase activity
LXH13_RS36045	COG0248	Ppx GppA phosphatase
LXH13_RS36095	COG2197	response regulator
LXH13_RS36105	COG1132	(ABC) transporter
LXH13_RS36115	COG0515	serine threonine protein kinase
LXH13_RS36190	COG3608	succinylglutamate desuccinylase aspartoacylase
LXH13_RS36190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LXH13_RS36200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LXH13_RS36240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LXH13_RS36265	COG1132	(ABC) transporter
LXH13_RS36280	COG4221	oxidoreductase activity
LXH13_RS36300	COG1846	Transcriptional regulator
LXH13_RS36300	COG1940	carbohydrate kinase activity
LXH13_RS36375	COG1072	(Pantothenic acid kinase))
LXH13_RS36395	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LXH13_RS36425	COG2409	Drug exporters of the RND superfamily
LXH13_RS36435	COG0673	inositol 2-dehydrogenase activity
LXH13_RS36440	COG0667	Aldo Keto reductase
LXH13_RS36510	COG1595	DNA-templated transcription, initiation
LXH13_RS36525	COG3290	protein histidine kinase activity
LXH13_RS36535	COG0456	acetyltransferase
LXH13_RS36545	COG3537	Alpha-1,2-mannosidase
LXH13_RS36595	COG0277	FAD linked oxidase domain protein
LXH13_RS36600	COG1597	lipid kinase activity
LXH13_RS36605	COG0667	Aldo Keto reductase
LXH13_RS36635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LXH13_RS36640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LXH13_RS36640	COG3608	succinylglutamate desuccinylase aspartoacylase
LXH13_RS36690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXH13_RS36725	COG3469	chitinase activity
LXH13_RS36735	COG1609	Transcriptional regulator
LXH13_RS36755	COG2770	Histidine kinase
LXH13_RS36755	COG2208	phosphoserine phosphatase activity
LXH13_RS36760	COG1765	OsmC-like protein
LXH13_RS36765	COG0205	6-phosphofructokinase activity
LXH13_RS36785	COG0789	Transcriptional regulator
LXH13_RS36795	COG2814	Major facilitator Superfamily
LXH13_RS36805	COG1309	transcriptional regulator
LXH13_RS36815	COG0477	Major facilitator Superfamily
LXH13_RS36825	COG1522	sequence-specific DNA binding
LXH13_RS36840	COG2814	Major facilitator Superfamily
LXH13_RS36860	COG3250	beta-galactosidase activity
LXH13_RS36870	COG1175	transmembrane transport
LXH13_RS36875	COG0395	ABC-type sugar transport system, permease component
LXH13_RS36905	COG0697	spore germination
LXH13_RS36915	COG1663	tetraacyldisaccharide 4'-kinase activity
LXH13_RS36980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LXH13_RS36985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXH13_RS36990	COG2050	protein possibly involved in aromatic compounds catabolism
LXH13_RS37000	COG3396	Phenylacetate-CoA oxygenase
LXH13_RS37005	COG3460	Phenylacetate-CoA oxygenase
LXH13_RS37010	COG3396	Phenylacetate-CoA oxygenase
LXH13_RS37015	COG2151	metal-sulfur cluster biosynthetic enzyme
LXH13_RS37020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LXH13_RS37030	COG0513	Belongs to the DEAD box helicase family
LXH13_RS37035	COG1278	Cold shock
LXH13_RS37040	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LXH13_RS37050	COG0583	DNA-binding transcription factor activity
LXH13_RS37055	COG1733	regulation of RNA biosynthetic process
LXH13_RS37065	COG0395	ABC-type sugar transport system, permease component
LXH13_RS37070	COG1175	transmembrane transport
LXH13_RS37090	COG0477	Major facilitator Superfamily
LXH13_RS37090	COG2814	Major facilitator Superfamily
LXH13_RS37100	COG2159	amidohydrolase
LXH13_RS37105	COG0745	RESPONSE REGULATOR receiver
LXH13_RS37110	COG2205	protein histidine kinase activity
LXH13_RS37140	COG2814	Major facilitator Superfamily
LXH13_RS37155	COG0583	DNA-binding transcription factor activity
LXH13_RS37185	COG1802	Transcriptional regulator
LXH13_RS37200	COG0656	L-ascorbic acid biosynthetic process
LXH13_RS37210	COG0667	Aldo Keto reductase
LXH13_RS37240	COG3250	beta-galactosidase activity
LXH13_RS37245	COG1609	Transcriptional regulator
LXH13_RS37250	COG1879	ABC-type sugar transport system periplasmic component
LXH13_RS37255	COG1129	ABC transporter
LXH13_RS37260	COG1172	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS37265	COG1172	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS37310	COG2197	response regulator
LXH13_RS37320	COG2272	Belongs to the type-B carboxylesterase lipase family
LXH13_RS37325	COG3938	Belongs to the proline racemase family
LXH13_RS37330	COG0583	DNA-binding transcription factor activity
LXH13_RS37420	COG2267	carboxylic ester hydrolase activity
LXH13_RS37435	COG0477	Major facilitator Superfamily
LXH13_RS37440	COG0477	Major facilitator Superfamily
LXH13_RS37460	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS37470	COG2080	2 iron, 2 sulfur cluster binding
LXH13_RS37475	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LXH13_RS37480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LXH13_RS37485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LXH13_RS37485	COG3608	succinylglutamate desuccinylase aspartoacylase
LXH13_RS37500	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS37575	COG0667	Aldo Keto reductase
LXH13_RS37590	COG0574	Belongs to the PEP-utilizing enzyme family
LXH13_RS37590	COG3848	Pyruvate phosphate dikinase
LXH13_RS37610	COG1609	Transcriptional regulator
LXH13_RS37630	COG0395	ABC-type sugar transport system, permease component
LXH13_RS37665	COG2197	response regulator
LXH13_RS37675	COG3537	Alpha-1,2-mannosidase
LXH13_RS37685	COG0702	epimerase
LXH13_RS37710	COG2197	response regulator
LXH13_RS37715	COG4585	Histidine kinase
LXH13_RS37730	COG2130	NADP-dependent
LXH13_RS37735	COG0583	DNA-binding transcription factor activity
LXH13_RS37740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LXH13_RS37760	COG1131	(ABC) transporter
LXH13_RS37795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXH13_RS37805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LXH13_RS37840	COG0237	dephospho-CoA kinase activity
LXH13_RS37870	COG1595	DNA-templated transcription, initiation
LXH13_RS37875	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS37875	COG1672	PFAM Archaeal ATPase
LXH13_RS37930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LXH13_RS37945	COG2084	Dehydrogenase
LXH13_RS37960	COG0022	dehydrogenase e1 component
LXH13_RS37965	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXH13_RS37970	COG0006	proline dipeptidase activity
LXH13_RS37985	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS37985	COG1672	PFAM Archaeal ATPase
LXH13_RS37990	COG1053	succinate dehydrogenase
LXH13_RS38015	COG0725	ABC transporter, periplasmic molybdate-binding protein
LXH13_RS38040	COG0395	ABC-type sugar transport system, permease component
LXH13_RS38045	COG1175	transmembrane transport
LXH13_RS38065	COG1609	Transcriptional regulator
LXH13_RS38095	COG0604	alcohol dehydrogenase
LXH13_RS38095	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS38095	COG3321	synthase
LXH13_RS38100	COG1129	ABC transporter
LXH13_RS38105	COG1172	Belongs to the binding-protein-dependent transport system permease family
LXH13_RS38125	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS38165	COG0596	Alpha beta hydrolase
LXH13_RS38165	COG2945	thiolester hydrolase activity
LXH13_RS38190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LXH13_RS38205	COG1609	Transcriptional regulator
LXH13_RS38260	COG0604	alcohol dehydrogenase
LXH13_RS38265	COG2362	D-Aminopeptidase
LXH13_RS38275	COG0006	proline dipeptidase activity
LXH13_RS38325	COG1802	Transcriptional regulator
LXH13_RS38340	COG0456	acetyltransferase
LXH13_RS38370	COG0154	amidase activity
LXH13_RS38380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LXH13_RS38380	COG3153	acetyltransferase
LXH13_RS38395	COG1970	mechanosensitive ion channel activity
LXH13_RS38400	COG4221	oxidoreductase activity
LXH13_RS38405	COG0789	Transcriptional regulator
LXH13_RS38410	COG0671	phosphoesterase, PA-phosphatase related
LXH13_RS38415	COG0671	phosphoesterase, PA-phosphatase related
LXH13_RS38420	COG0586	Pfam SNARE associated Golgi protein
LXH13_RS38450	COG4585	Histidine kinase
LXH13_RS38480	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS38480	COG0604	alcohol dehydrogenase
LXH13_RS38480	COG3321	synthase
LXH13_RS38500	COG1733	regulation of RNA biosynthetic process
LXH13_RS38540	COG0745	RESPONSE REGULATOR receiver
LXH13_RS38545	COG2205	protein histidine kinase activity
LXH13_RS38580	COG1136	(ABC) transporter
LXH13_RS38600	COG0601	transmembrane transport
LXH13_RS38605	COG0444	Belongs to the ABC transporter superfamily
LXH13_RS38610	COG4608	Belongs to the ABC transporter superfamily
LXH13_RS38630	COG4948	Mandelate Racemase Muconate Lactonizing
LXH13_RS38675	COG3321	synthase
LXH13_RS38675	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS38675	COG0604	alcohol dehydrogenase
LXH13_RS38680	COG1309	transcriptional regulator
LXH13_RS38690	COG1764	response to oxidative stress
LXH13_RS38710	COG2124	cytochrome p450
LXH13_RS38745	COG1120	ATPase activity
LXH13_RS38785	COG1116	anion transmembrane transporter activity
LXH13_RS38800	COG2159	amidohydrolase
LXH13_RS38805	COG0028	Belongs to the TPP enzyme family
LXH13_RS38850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXH13_RS38855	COG2706	6-phosphogluconolactonase activity
LXH13_RS38910	COG1609	Transcriptional regulator
LXH13_RS38920	COG1175	transmembrane transport
LXH13_RS38930	COG1472	Belongs to the glycosyl hydrolase 3 family
LXH13_RS38940	COG0129	dihydroxy-acid dehydratase activity
LXH13_RS38945	COG2186	Transcriptional regulator
LXH13_RS38965	COG0789	Transcriptional regulator
LXH13_RS38970	COG2130	NADP-dependent
LXH13_RS39005	COG0596	Alpha beta hydrolase
LXH13_RS39040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LXH13_RS39055	COG3350	monooxygenase activity
LXH13_RS39060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LXH13_RS39090	COG0459	protein refolding
LXH13_RS39115	COG4989	oxidoreductase activity
LXH13_RS39135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LXH13_RS39160	COG2353	YceI-like domain
LXH13_RS39170	COG0604	alcohol dehydrogenase
LXH13_RS39225	COG1595	DNA-templated transcription, initiation
LXH13_RS39230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LXH13_RS39245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LXH13_RS39260	COG2837	iron assimilation
LXH13_RS39275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LXH13_RS39300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXH13_RS39305	COG1028	Short-chain dehydrogenase reductase Sdr
LXH13_RS39310	COG3118	belongs to the thioredoxin family
LXH13_RS39315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LXH13_RS39325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LXH13_RS39340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LXH13_RS39350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXH13_RS39370	COG1672	PFAM Archaeal ATPase
LXH13_RS39370	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LXH13_RS39375	COG3629	intracellular signal transduction
LXH13_RS39375	COG3903	Transcriptional regulator
LXH13_RS39410	COG1414	Transcriptional regulator
LXH13_RS39415	COG2814	Major facilitator Superfamily
LXH13_RS39425	COG2315	Protein conserved in bacteria
LXH13_RS39430	COG0604	alcohol dehydrogenase
LXH13_RS39435	COG0778	Nitroreductase
LXH13_RS39660	COG0515	serine threonine protein kinase
LXH13_RS39730	COG0651	ATP synthesis coupled electron transport
LXH13_RS39755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system