locus-tag class description HB370_RS00125 ENOG4105ESF Peptidoglycan binding domain protein HB370_RS00190 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS00240 ENOG4108XG2 Histidine kinase HB370_RS00245 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS00270 ENOG4105PWE CRISPR-associated protein cas2 HB370_RS00275 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HB370_RS00315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HB370_RS00355 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HB370_RS00360 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HB370_RS00375 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HB370_RS00385 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HB370_RS00390 ENOG4105CHR reductase HB370_RS00420 ENOG4105C0W non-ribosomal peptide synthetase HB370_RS00475 ENOG4108J2P Alpha beta hydrolase fold HB370_RS00510 ENOG4107R4N Cell wall formation (By similarity) HB370_RS00575 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HB370_RS00640 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS00665 ENOG4105CPQ Dehydrogenase HB370_RS00740 ENOG4105DRS transport system, permease HB370_RS00835 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HB370_RS00855 ENOG4105FB9 CRISPR-associated protein HB370_RS00900 ENOG4105CT3 Monooxygenase HB370_RS00905 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HB370_RS00920 ENOG4105C26 Dehydrogenase HB370_RS00925 ENOG4107QPD alcohol dehydrogenase HB370_RS00935 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS00940 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS00955 ENOG410836F Transposase HB370_RS00985 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HB370_RS01025 ENOG4105FDF Could be involved in DNA repair (By similarity) HB370_RS01035 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HB370_RS01040 ENOG4105ENX hydrolase HB370_RS01180 ENOG4108ZT0 50S ribosomal protein l17 HB370_RS01215 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HB370_RS01220 ENOG4105EMU Dehydrogenase HB370_RS01225 ENOG4108JGH Tetr family transcriptional regulator HB370_RS01240 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HB370_RS01265 ENOG4105BZ9 Cytochrome C oxidase, subunit I HB370_RS01285 ENOG4105CIR epoxide hydrolase HB370_RS01330 ENOG4108QBF Transcriptional regulator HB370_RS01340 ENOG4105JSC dimethylmenaquinone methyltransferase HB370_RS01355 ENOG4105D2S major facilitator superfamily HB370_RS01360 ENOG4105TVJ transport system, permease HB370_RS01365 ENOG4105DQ5 transport system permease protein HB370_RS01370 ENOG4105E93 esterase HB370_RS01375 ENOG4108HUF Transporter HB370_RS01380 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HB370_RS01385 ENOG4105E4F Isochorismate synthase HB370_RS01390 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HB370_RS01395 ENOG4105WQI isochorismatase HB370_RS01400 ENOG4105WQI isochorismatase HB370_RS01405 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS01420 ENOG4105E93 esterase HB370_RS01445 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HB370_RS01450 ENOG4105CPC Aldo Keto reductase HB370_RS01460 ENOG4108RZE Tetr family transcriptional regulator HB370_RS01480 ENOG4108IG5 Transcriptional regulator HB370_RS01505 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HB370_RS01515 ENOG4108UU4 oxidoreductase (Short chain dehydrogenase reductase family) HB370_RS01560 ENOG4107RSM transcriptional regulator HB370_RS01575 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HB370_RS01660 ENOG4105EMN RNA polymerase sigma factor HB370_RS01665 ENOG4105VBF alkaline shock protein HB370_RS01690 ENOG4105VEQ Cold shock protein HB370_RS01700 ENOG4105EMN RNA polymerase sigma factor HB370_RS01730 ENOG4105F27 Major Facilitator HB370_RS01745 ENOG4105CV8 reductase HB370_RS01750 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HB370_RS01785 ENOG4107WFU Glutamate mutase subunit sigma HB370_RS01790 ENOG4105CIH Imidazole acetol-phosphate transaminase HB370_RS01800 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HB370_RS01820 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HB370_RS01830 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HB370_RS01845 ENOG4106YKD Cytochrome p-450 HB370_RS01870 ENOG4105CIH Imidazole acetol-phosphate transaminase HB370_RS01885 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HB370_RS01930 ENOG4105DGI Alkaline phosphatase HB370_RS01940 ENOG4105EU0 Major facilitator Superfamily HB370_RS01945 ENOG4105R1U AraC Family Transcriptional Regulator HB370_RS01960 ENOG4105W1Y Transcriptional regulator HB370_RS01965 ENOG4105CHH sulfate transporter HB370_RS02070 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HB370_RS02085 ENOG41067TZ transcriptional regulator, MarR family HB370_RS02090 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HB370_RS02095 ENOG4108KB2 LysR family Transcriptional regulator HB370_RS02105 ENOG4106A3M Cytochrome p-450 HB370_RS02160 ENOG4105SUT Transcriptional Regulator AraC Family HB370_RS02185 ENOG4108PC0 lipolytic protein G-D-S-L family HB370_RS02285 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HB370_RS02325 ENOG4105F27 Major Facilitator HB370_RS02340 ENOG4107S46 esterase, PHB depolymerase HB370_RS02350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HB370_RS02385 ENOG4105C0Z ABC transporter HB370_RS02390 ENOG4108IV0 ABC, transporter HB370_RS02395 ENOG4105G9B Transcriptional regulator HB370_RS02400 ENOG4108W5M transcriptional regulator HB370_RS02455 ENOG4108NNZ chitinase HB370_RS02470 ENOG4105BZU Histidine kinase HB370_RS02485 ENOG4107S2E monooxygenase HB370_RS02545 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HB370_RS02550 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HB370_RS02555 ENOG4107B2H carbonic anhydrase HB370_RS02560 ENOG4105DND Transcriptional regulator HB370_RS02575 ENOG4108RWI nicotinamidase HB370_RS02580 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HB370_RS02605 ENOG4105CJ1 ABC, transporter HB370_RS02610 ENOG4107RCI amp-dependent synthetase and ligase HB370_RS02615 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB370_RS02635 ENOG4107SQU synthase HB370_RS02670 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS02705 ENOG4105EQX glucarate dehydratase HB370_RS02740 ENOG4105CGD Nad-dependent epimerase dehydratase HB370_RS02755 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HB370_RS02770 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB370_RS02785 ENOG4108YYC ycei family HB370_RS02815 ENOG4105CHR reductase HB370_RS02835 ENOG4108SC4 )-transporter HB370_RS02935 ENOG4105CH2 amidohydrolase HB370_RS02950 ENOG41064MX Tetr family transcriptional regulator HB370_RS02960 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HB370_RS02965 ENOG4108UTZ Dihydroxyacetone kinase HB370_RS02970 ENOG4105CMT Dihydroxyacetone kinase HB370_RS02975 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HB370_RS02985 ENOG4107FKK extracellular solute-binding protein family 1 HB370_RS02990 ENOG4105CJQ hydrolase, family 31 HB370_RS03035 ENOG4108IG5 Transcriptional regulator HB370_RS03040 ENOG4107RDB Major Facilitator HB370_RS03045 ENOG4108RYK Nad-dependent epimerase dehydratase HB370_RS03050 ENOG4105KVH Transcriptional regulator HB370_RS03085 ENOG4105ECQ AraC Family Transcriptional Regulator HB370_RS03090 ENOG4105DND Transcriptional regulator HB370_RS03100 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HB370_RS03105 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS03175 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS03185 ENOG4105C5I Dehydrogenase HB370_RS03190 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HB370_RS03235 ENOG4107S9F NmrA family HB370_RS03240 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HB370_RS03250 ENOG4108YXU transcriptional regulator AsnC family HB370_RS03255 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HB370_RS03260 ENOG4105CI2 imidazolone-5-propionate hydrolase HB370_RS03270 ENOG41067TZ transcriptional regulator, MarR family HB370_RS03275 ENOG4105G6Z alkaline phosphatase HB370_RS03325 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HB370_RS03330 ENOG4107RJ1 sodium solute HB370_RS03360 ENOG41066UM arsR family transcriptional regulator HB370_RS03390 ENOG41067HS methyltransferase HB370_RS03395 ENOG4105CUB amino acid HB370_RS03420 ENOG4108IXY short-chain dehydrogenase reductase HB370_RS03475 ENOG4108TKH Nitroreductase HB370_RS03480 ENOG4108IG5 Transcriptional regulator HB370_RS03530 ENOG4105DIK (ABC) transporter HB370_RS03635 ENOG41068HZ 50S ribosomal protein L32 HB370_RS03650 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HB370_RS03665 ENOG4107S8C mandelate racemase muconate lactonizing HB370_RS03680 ENOG4105E43 Extracellular solute-binding protein, family 5 HB370_RS03690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS03695 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HB370_RS03715 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HB370_RS03730 ENOG4105DMF Dehydrogenase HB370_RS03765 ENOG4108HMN Caspase domain HB370_RS03805 ENOG4105C6Y Udp-glucose 6-dehydrogenase HB370_RS03830 ENOG4105BZN citrate synthase HB370_RS03835 ENOG4107QM5 aconitate hydratase HB370_RS03845 ENOG4105DTQ mandelate racemase muconate lactonizing HB370_RS03850 ENOG4105C5I Dehydrogenase HB370_RS03870 ENOG4108MRH transcriptional regulatory protein HB370_RS03875 ENOG4108TQ9 Histidine kinase HB370_RS03880 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS03910 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HB370_RS03915 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HB370_RS03930 ENOG4105EBM Alpha Beta Hydrolase Fold protein HB370_RS03945 ENOG4105E09 nadh pyrophosphatase HB370_RS03955 ENOG41061H0 Monooxygenase HB370_RS03970 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HB370_RS03975 ENOG4105E6M Sulphatase-modifying factor protein HB370_RS03990 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HB370_RS03995 ENOG4105EHG Permease protein HB370_RS04005 ENOG4108HMN Caspase domain HB370_RS04035 ENOG4105EQ0 Major Facilitator superfamily HB370_RS04055 ENOG4105KVH Transcriptional regulator HB370_RS04090 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HB370_RS04110 ENOG4105KME endoribonuclease L-psp HB370_RS04140 ENOG4105F27 Major Facilitator HB370_RS04160 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HB370_RS04180 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HB370_RS04185 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HB370_RS04195 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HB370_RS04205 ENOG4105D49 3-dehydroquinate synthase HB370_RS04230 ENOG4108IG5 Transcriptional regulator HB370_RS04265 ENOG4107SCK Monooxygenase HB370_RS04275 ENOG4105EEM helicase HB370_RS04280 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HB370_RS04295 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HB370_RS04300 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HB370_RS04305 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HB370_RS04315 ENOG4105C0X amino acid HB370_RS04320 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HB370_RS04340 ENOG4105DJI Methylaspartate mutase, E subunit HB370_RS04400 ENOG4106YKD Cytochrome p-450 HB370_RS04420 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS04435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB370_RS04475 ENOG4105DZ2 Transcriptional regulator HB370_RS04485 ENOG4108YYQ gCN5-related N-acetyltransferase HB370_RS04515 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HB370_RS04535 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS04540 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HB370_RS04545 ENOG4107U9T Pfam:Ribonuclease_BN HB370_RS04560 ENOG4108PJD permease HB370_RS04580 ENOG4108YYC ycei family HB370_RS04585 ENOG4108YYC ycei family HB370_RS04615 ENOG4105KT7 mgtC SapB transporter HB370_RS04630 ENOG4105C02 permease HB370_RS04640 ENOG4105EBR Carboxylesterase HB370_RS04650 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HB370_RS04675 ENOG4105CMR udp-glucose 4-epimerase HB370_RS04685 ENOG4108IAJ Nad-dependent epimerase dehydratase HB370_RS04695 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HB370_RS04725 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HB370_RS04730 ENOG4105CSH Transporter HB370_RS04750 ENOG4107T5V SNARE associated Golgi HB370_RS04815 ENOG4107MM9 BNR Asp-box repeat-containing protein HB370_RS04825 ENOG4108KXM LysR family Transcriptional regulator HB370_RS04845 ENOG4105KVH Transcriptional regulator HB370_RS04925 ENOG4107RTD sua5 ycio yrdc ywlc family protein HB370_RS04965 ENOG4105DQE DNA ligase HB370_RS05000 ENOG4108K8U Glycerol operon regulatory protein HB370_RS05005 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HB370_RS05010 ENOG4105DQE DNA ligase HB370_RS05015 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HB370_RS05055 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HB370_RS05070 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HB370_RS05075 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HB370_RS05095 ENOG4105CEP NADH dehydrogenase HB370_RS05175 ENOG4105C5X domain protein HB370_RS05220 ENOG4105C7B Threonine dehydratase HB370_RS05235 ENOG4108R5S membrane HB370_RS05245 ENOG4107SET aldo keto reductase HB370_RS05255 ENOG4107RSM transcriptional regulator HB370_RS05280 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HB370_RS05295 ENOG4105WBV Transcriptional regulator HB370_RS05300 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS05315 ENOG4105CPC Aldo Keto reductase HB370_RS05320 ENOG4108M0I Transcriptional regulator HB370_RS05330 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HB370_RS05335 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HB370_RS05370 ENOG4108K8S endonuclease I HB370_RS05375 ENOG4107S5I aldo keto reductase HB370_RS05385 ENOG4105C26 Dehydrogenase HB370_RS05395 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HB370_RS05420 ENOG4107QHQ amino acid HB370_RS05465 ENOG4105CAQ asparagine synthetase HB370_RS05475 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HB370_RS05550 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS05560 ENOG4107S1E Beta-lactamase HB370_RS05635 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HB370_RS05640 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HB370_RS05645 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HB370_RS05650 ENOG4105CPK Glycosyl transferase (Group 1 HB370_RS05660 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HB370_RS05675 ENOG4108IAJ Nad-dependent epimerase dehydratase HB370_RS05695 ENOG4105CMT Dihydroxyacetone kinase HB370_RS05700 ENOG4108UTZ Dihydroxyacetone kinase HB370_RS05705 ENOG4105VDH Dihydroxyacetone kinase HB370_RS05730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB370_RS05735 ENOG41090U3 tautomerase HB370_RS05755 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HB370_RS05790 ENOG4105I82 acetyl xylan esterase HB370_RS05800 ENOG4105FDP GntR family transcriptional regulator HB370_RS05830 ENOG4105DZ1 carboxypeptidase HB370_RS05835 ENOG41090CE integral membrane protein HB370_RS05845 ENOG4108IJ0 Aspartate ammonia-lyase HB370_RS05860 ENOG41073TP transcriptional regulator HB370_RS05865 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HB370_RS05875 ENOG4105KJJ Uncharacterized ACR, COG1993 HB370_RS05905 ENOG4107YY3 extracellular solute-binding protein family 1 HB370_RS05920 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS05925 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS05930 ENOG4105BZU Histidine kinase HB370_RS05935 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HB370_RS05945 ENOG4108UYE Lactoylglutathione lyase HB370_RS06015 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HB370_RS06030 ENOG4108SGR YheO domain-containing protein HB370_RS06045 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HB370_RS06050 ENOG4105E39 Enoyl-CoA hydratase HB370_RS06065 ENOG4105ZXK Dehydrogenase HB370_RS06080 ENOG4105FP9 thiamine pyrophosphate HB370_RS06100 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HB370_RS06105 ENOG4105DG6 mannose-6-phosphate isomerase HB370_RS06115 ENOG4105DSG hydrolase family 43 HB370_RS06145 ENOG4105CVK Glutamate decarboxylase HB370_RS06220 ENOG4105C9U ATP-dependent DNA helicase RecQ HB370_RS06230 ENOG4105CAQ asparagine synthetase HB370_RS06235 ENOG4105C0I Conserved Protein HB370_RS06245 ENOG4105EMU Dehydrogenase HB370_RS06250 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS06255 ENOG4108Z40 Transcriptional regulator HB370_RS06310 ENOG4105CYP glycoside hydrolase, family HB370_RS06325 ENOG4105KF0 sporulation and cell division protein, SsgA HB370_RS06370 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HB370_RS06375 ENOG4108UZX fmn reductase HB370_RS06400 ENOG4105C7K acetolactate synthase HB370_RS06460 ENOG4105CVR type I restriction-modification system HB370_RS06485 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HB370_RS06570 ENOG4107RRZ synthase HB370_RS06610 ENOG4105MVE transcriptional regulator HB370_RS06660 ENOG4105DKQ ROK family HB370_RS06670 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HB370_RS06680 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HB370_RS06685 ENOG4105E98 transcriptional regulator DeoR family HB370_RS06705 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HB370_RS06720 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HB370_RS06735 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HB370_RS06740 ENOG4107PP3 Acetylornithine deacetylase HB370_RS06745 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HB370_RS06750 ENOG4105I1F Resistance protein HB370_RS06760 ENOG4105EX0 alpha-galactosidase HB370_RS06785 ENOG41060NJ transcriptional regulator HB370_RS06800 ENOG4105C10 Electron transfer flavoprotein HB370_RS06820 ENOG4105PSQ Acyl-transferase HB370_RS06845 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HB370_RS06860 ENOG4105CPC Aldo Keto reductase HB370_RS06880 ENOG410841Q phosphoesterase PA-phosphatase related protein HB370_RS06895 ENOG4105EQH reductase HB370_RS06905 ENOG4105YVS arsR family transcriptional regulator HB370_RS06910 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB370_RS06915 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HB370_RS06925 ENOG4107S46 esterase, PHB depolymerase HB370_RS06935 ENOG4105DKK Benzoate HB370_RS06945 ENOG4105CSU acyl-Coa dehydrogenase HB370_RS06960 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HB370_RS06975 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HB370_RS06990 ENOG4107VXZ Hydrolase HB370_RS07030 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HB370_RS07035 ENOG4105E2Y ABC, transporter HB370_RS07045 ENOG4105CT3 Monooxygenase HB370_RS07055 ENOG4105BZ1 (ABC) transporter HB370_RS07085 ENOG4105BZ1 (ABC) transporter HB370_RS07110 ENOG4105C29 acyl-CoA thioesterase HB370_RS07120 ENOG4105GWZ Roadblock lc7 family protein HB370_RS07180 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HB370_RS07185 ENOG4105C85 amino acid HB370_RS07190 ENOG4107SCA Formamidase (EC 3.5.1.49) HB370_RS07200 ENOG4108W2Y isochorismatase HB370_RS07210 ENOG4105E8R UPF0173 metal-dependent hydrolase HB370_RS07230 ENOG4105VEQ Cold shock protein HB370_RS07240 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HB370_RS07260 ENOG4106W5V Membrane HB370_RS07315 ENOG4105D2B acyl-CoA dehydrogenase HB370_RS07320 ENOG4105D2B acyl-CoA dehydrogenase HB370_RS07325 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HB370_RS07335 ENOG4105C3M thioredoxin reductase HB370_RS07340 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HB370_RS07350 ENOG4105C26 Dehydrogenase HB370_RS07360 ENOG41065KQ synthase HB370_RS07365 ENOG4106A3M Cytochrome p-450 HB370_RS07375 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS07385 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HB370_RS07395 ENOG4105F1K Glutamine amidotransferase HB370_RS07400 ENOG4105CTQ phosphohexokinase HB370_RS07415 ENOG4108VVK transcriptional Regulator, AsnC HB370_RS07420 ENOG4105CIK Amidinotransferase HB370_RS07425 ENOG4105C8Y Acetylornithine aminotransferase HB370_RS07440 ENOG4105F6E Acyl-transferase HB370_RS07460 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HB370_RS07470 ENOG4105CQM Urea amidohydrolase subunit alpha HB370_RS07475 ENOG4105KI2 Urea amidohydrolase subunit beta HB370_RS07480 ENOG4108YZ9 Urea amidohydrolase subunit gamma HB370_RS07525 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HB370_RS07530 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HB370_RS07555 ENOG4105FBW Monooxygenase HB370_RS07560 ENOG4108R6G acetyltransferase HB370_RS07580 ENOG4105C83 adenylosuccinate lyase HB370_RS07585 ENOG4108VCA G U mismatch-specific DNA glycosylase HB370_RS07610 ENOG4105BZU Histidine kinase HB370_RS07615 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS07625 ENOG4105FDP GntR family transcriptional regulator HB370_RS07630 ENOG4108KPJ rna polymerase sigma factor HB370_RS07665 ENOG4108PSK reductase HB370_RS07715 ENOG4105EYH Exonuclease HB370_RS07725 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HB370_RS07740 ENOG4105K4P CoA-binding domain protein HB370_RS07745 ENOG41082SX arsR family transcriptional regulator HB370_RS07770 ENOG4108UW5 maltose o-acetyltransferase HB370_RS07775 ENOG4108Z0R Transferase HB370_RS07840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HB370_RS07860 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HB370_RS07865 ENOG4105EP9 oxidoreductase HB370_RS07875 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HB370_RS07880 ENOG4105DEF Extracellular solute-binding protein, family 5 HB370_RS07885 ENOG4105CHR reductase HB370_RS07925 ENOG4105DXI Major Facilitator superfamily HB370_RS07950 ENOG4108Q5Y Membrane HB370_RS07955 ENOG4105CSW GntR family transcriptional regulator HB370_RS08005 ENOG4105JAB phenazine biosynthesis protein, phzf family HB370_RS08050 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HB370_RS08065 ENOG4105F4R Transcriptional regulator mode HB370_RS08070 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HB370_RS08080 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HB370_RS08150 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HB370_RS08160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HB370_RS08185 ENOG4105BZU Histidine kinase HB370_RS08205 ENOG4105GWZ Roadblock lc7 family protein HB370_RS08220 ENOG41069M3 Transcriptional regulator HB370_RS08250 ENOG4105E7W lamb ycsf family protein HB370_RS08255 ENOG4105P4J Allophanate hydrolase, subunit 1 HB370_RS08265 ENOG4108MJN Glycosyl Transferase HB370_RS08280 ENOG4105JXB ankyrin repeat-containing protein HB370_RS08295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HB370_RS08300 ENOG4108VW9 Membrane HB370_RS08310 ENOG4105Q70 HB370_RS08315 ENOG4105FS0 cytoplasmic membrane protein HB370_RS08320 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HB370_RS08330 ENOG4105EW9 transcriptional regulator AsnC family HB370_RS08345 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS08375 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HB370_RS08400 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HB370_RS08405 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HB370_RS08410 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HB370_RS08415 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HB370_RS08430 ENOG4105E2R ROK family HB370_RS08440 ENOG4105C2W permease HB370_RS08465 ENOG4105CUB amino acid HB370_RS08490 ENOG4105DKT Transcriptional regulator HB370_RS08495 ENOG4105DJV ribulose-phosphate 3-epimerase HB370_RS08505 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HB370_RS08520 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HB370_RS08535 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HB370_RS08545 ENOG4105SKN orotidine 5''-phosphate decarboxylase HB370_RS08550 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HB370_RS08555 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HB370_RS08560 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HB370_RS08570 ENOG4105CD3 dihydroorotase HB370_RS08575 ENOG4105CXT aspartate transcarbamylase HB370_RS08580 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HB370_RS08590 ENOG410803B Involved in the transcription termination process (By similarity) HB370_RS08595 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HB370_RS08600 ENOG4105DC7 peptidase M24 HB370_RS08610 ENOG4105D49 3-dehydroquinate synthase HB370_RS08615 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HB370_RS08620 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HB370_RS08625 ENOG4105E2X shikimate dehydrogenase HB370_RS08630 ENOG4105HHA aminodeoxychorismate lyase HB370_RS08635 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HB370_RS08640 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HB370_RS08660 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HB370_RS08675 ENOG4105CUT histidyl-tRNA synthetase HB370_RS08685 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HB370_RS08690 ENOG4105C99 atpase involved in dna repair HB370_RS08695 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HB370_RS08705 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HB370_RS08710 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HB370_RS08715 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HB370_RS08725 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HB370_RS08730 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HB370_RS08735 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HB370_RS08740 ENOG4105CDY transcriptional regulatory protein HB370_RS08745 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HB370_RS08750 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HB370_RS08760 ENOG4105E2K Glycosyl transferase (Group 1 HB370_RS08765 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HB370_RS08790 ENOG4105C22 threonyL-tRNA synthetase HB370_RS08795 ENOG4108IRC dna polymerase iii HB370_RS08810 ENOG4105EKC HB370_RS08820 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HB370_RS08825 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HB370_RS08850 ENOG4105KF0 sporulation and cell division protein, SsgA HB370_RS08885 ENOG4105CRQ synthase (Component I) HB370_RS08940 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HB370_RS08945 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HB370_RS08960 ENOG4105D01 (LipO)protein HB370_RS08965 ENOG4105D01 (LipO)protein HB370_RS08970 ENOG4108UMI ABC transporter, permease HB370_RS08975 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HB370_RS09010 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS09015 ENOG4107R16 Multicopper oxidase HB370_RS09020 ENOG4105C57 major facilitator superfamily HB370_RS09025 ENOG4105RJZ Transcriptional regulator HB370_RS09035 ENOG4105CH7 arginosuccinase HB370_RS09040 ENOG4105CDH Citrulline--aspartate ligase HB370_RS09070 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HB370_RS09075 ENOG4105C8Y Acetylornithine aminotransferase HB370_RS09080 ENOG4105CAS nag kinase HB370_RS09085 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HB370_RS09090 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HB370_RS09100 ENOG4105CKK Glycosyl transferase, family 2 HB370_RS09140 ENOG4105T38 integral membrane protein HB370_RS09150 ENOG4105F32 YngK protein HB370_RS09180 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HB370_RS09185 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HB370_RS09190 ENOG4105BZU Histidine kinase HB370_RS09195 ENOG4108RWN rrna methyltransferase HB370_RS09200 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HB370_RS09205 ENOG41084BS 50S ribosomal protein L35 HB370_RS09210 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HB370_RS09250 ENOG4105C26 Dehydrogenase HB370_RS09255 ENOG4105C5F glutamine synthetase HB370_RS09260 ENOG41073TP transcriptional regulator HB370_RS09265 ENOG4108Z86 Glutamine amidotransferase HB370_RS09285 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HB370_RS09295 ENOG4108HQS Glycine betaine HB370_RS09300 ENOG4108IJ7 Glycine betaine HB370_RS09305 ENOG4105HFS 5'-3' exonuclease HB370_RS09320 ENOG4105D3G Pseudouridine synthase HB370_RS09355 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HB370_RS09360 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HB370_RS09395 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HB370_RS09405 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS09410 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HB370_RS09415 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HB370_RS09425 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HB370_RS09430 ENOG4105E5F proteasome HB370_RS09435 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HB370_RS09470 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS09475 ENOG4105DEF Extracellular solute-binding protein, family 5 HB370_RS09480 ENOG4105DEF Extracellular solute-binding protein, family 5 HB370_RS09485 ENOG4107URF beta-phospho-glucomutase HB370_RS09490 ENOG4105C3R Methionine synthase HB370_RS09495 ENOG4108K8U Glycerol operon regulatory protein HB370_RS09500 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HB370_RS09505 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HB370_RS09510 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HB370_RS09520 ENOG4105C8N cysteinyl-tRNA synthetase HB370_RS09535 ENOG4108RH7 phosphoglycerate mutase HB370_RS09540 ENOG4105D7N magnesium and cobalt transport protein CorA HB370_RS09550 ENOG4105DYW oxidoreductase HB370_RS09555 ENOG4105CPC Aldo Keto reductase HB370_RS09575 ENOG4105S2J secreted protein HB370_RS09585 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HB370_RS09595 ENOG4105DCG PHP domain protein HB370_RS09615 ENOG4105K5B UPF0225 protein HB370_RS09620 ENOG4105C6F GntR Family Transcriptional Regulator HB370_RS09625 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HB370_RS09630 ENOG4105C6Z Gluconate HB370_RS09645 ENOG4105PTV Nudix Hydrolase HB370_RS09650 ENOG4105VG5 Membrane HB370_RS09665 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HB370_RS09690 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HB370_RS09700 ENOG4108IG5 Transcriptional regulator HB370_RS09705 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS09715 ENOG4105EHZ conserved protein UCP016719 HB370_RS09740 ENOG4108Z4X TRANSCRIPTIONal HB370_RS09755 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS09765 ENOG4108ZHR arsR family transcriptional regulator HB370_RS09795 ENOG4105D4T Citrate transporter HB370_RS09800 ENOG4108SGK Tetr family transcriptional regulator HB370_RS09810 ENOG4105F1J Homogentisate 1,2-dioxygenase HB370_RS09840 ENOG4108TCJ secreted hydrolase HB370_RS09860 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HB370_RS09870 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HB370_RS09900 ENOG4105C0B DNA polymerase III (alpha subunit) HB370_RS09905 ENOG4106NMR serine protease HB370_RS09935 ENOG4105EAD ABC transporter HB370_RS09945 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HB370_RS09950 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS09955 ENOG4105C57 major facilitator superfamily HB370_RS09970 ENOG410841Q phosphoesterase PA-phosphatase related protein HB370_RS09980 ENOG4105BZ9 Cytochrome C oxidase, subunit I HB370_RS10000 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HB370_RS10010 ENOG4105CAT Cytidine monophosphate kinase HB370_RS10035 ENOG410756H nucleotidyltransferase HB370_RS10040 ENOG41065RQ ADP-ribosylation crystallin J1 HB370_RS10045 ENOG4105FE9 pseudouridine synthase HB370_RS10050 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HB370_RS10055 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HB370_RS10070 ENOG4105DCF alanine dehydrogenase HB370_RS10080 ENOG4108YZ4 nudix hydrolase HB370_RS10085 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HB370_RS10090 ENOG4105BZP glycoside hydrolase 15-related HB370_RS10095 ENOG4105DNP FAD linked oxidase domain protein HB370_RS10100 ENOG4105CVN desaturase HB370_RS10120 ENOG4107QPH glycogen) synthase HB370_RS10130 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HB370_RS10135 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HB370_RS10155 ENOG4105E0A ABC, transporter HB370_RS10160 ENOG4105TVJ transport system, permease HB370_RS10165 ENOG4105DQ5 transport system permease protein HB370_RS10170 ENOG4105DSU hydrolase HB370_RS10200 ENOG4108VX5 3-methyladenine DNA glycosylase HB370_RS10210 ENOG4108V1U phospholipid-binding protein HB370_RS10230 ENOG4105DKW ABC transporter HB370_RS10245 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS10250 ENOG4105BZU Histidine kinase HB370_RS10260 ENOG4105IDI abc transporter atp-binding protein HB370_RS10265 ENOG4105EAC phosphoserine phosphatase HB370_RS10285 ENOG4107YCY Transcriptional regulator HB370_RS10330 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HB370_RS10350 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HB370_RS10355 ENOG4107QN1 sodium solute HB370_RS10370 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HB370_RS10375 ENOG4105E2A Dehydrogenase HB370_RS10395 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HB370_RS10410 ENOG4105BZP glycoside hydrolase 15-related HB370_RS10420 ENOG4106YT9 Enoyl-CoA hydratase HB370_RS10430 ENOG4105C5H ABC transporter HB370_RS10450 ENOG4107W7X Aldolase HB370_RS10470 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HB370_RS10475 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HB370_RS10480 ENOG4105CTK cobaltochelatase, cobn subunit HB370_RS10490 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HB370_RS10495 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HB370_RS10510 ENOG4105CIA precorrin-4 C(11)-methyltransferase HB370_RS10520 ENOG4105E4R Precorrin-3B C17-methyltransferase HB370_RS10525 ENOG41081F0 Precorrin-8x methylmutase HB370_RS10555 ENOG4105EAD ABC transporter HB370_RS10560 ENOG4105CT1 (ABC) transporter HB370_RS10565 ENOG4105C5R Aminotransferase HB370_RS10570 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HB370_RS10575 ENOG4108JPW Aminotransferase HB370_RS10580 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HB370_RS10585 ENOG4105EV8 ectoine hydroxylase HB370_RS10590 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB370_RS10595 ENOG4108ZT1 Transcriptional regulator HB370_RS10600 ENOG4105C9B Cysteine desulfurase HB370_RS10630 ENOG4107HP6 Transcriptional regulator HB370_RS10645 ENOG4105NAF rna polymerase sigma factor HB370_RS10660 ENOG4105NBR Pectinesterase HB370_RS10670 ENOG4107TDE lipolytic protein G-D-S-L family HB370_RS10705 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HB370_RS10715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB370_RS10720 ENOG4105DRR Transcriptional regulator, GntR family HB370_RS10740 ENOG4105E9Z Nad-dependent epimerase dehydratase HB370_RS10745 ENOG4105E98 transcriptional regulator DeoR family HB370_RS10765 ENOG4105CPQ Dehydrogenase HB370_RS10775 ENOG4105XEA Tetr family transcriptional regulator HB370_RS10815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB370_RS10820 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HB370_RS10825 ENOG4108RFG Tetr family transcriptional regulator HB370_RS10830 ENOG410814C multidrug resistance protein HB370_RS10835 ENOG4105VG1 fes assembly suf system protein HB370_RS10840 ENOG4108UNV SUF system FeS assembly protein, NifU family HB370_RS10845 ENOG4105C9B Cysteine desulfurase HB370_RS10850 ENOG4105C3K feS assembly ATPase SufC HB370_RS10860 ENOG4105JRK feS assembly protein SufD HB370_RS10875 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HB370_RS10880 ENOG4105CJ1 ABC, transporter HB370_RS10890 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HB370_RS10905 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HB370_RS10915 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HB370_RS10930 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HB370_RS10935 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HB370_RS10940 ENOG4108WFR AraC Family Transcriptional Regulator HB370_RS10960 ENOG4108IND Tetr family transcriptional regulator HB370_RS10970 ENOG4108M8W Monooxygenase HB370_RS10980 ENOG4105C0W non-ribosomal peptide synthetase HB370_RS11005 ENOG4105DEN Luciferase family HB370_RS11010 ENOG4107QP8 phosphohexose isomerase HB370_RS11030 ENOG4105CP7 Triose-phosphate isomerase HB370_RS11035 ENOG4105BZA Phosphoglycerate kinase HB370_RS11040 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HB370_RS11050 ENOG4105CIE May be required for sporulation (By similarity) HB370_RS11055 ENOG4105CHW UPF0052 protein HB370_RS11060 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HB370_RS11065 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HB370_RS11085 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HB370_RS11095 ENOG4107VMB Beta-lactamase domain protein HB370_RS11105 ENOG4105E5Q amino acid AbC transporter HB370_RS11115 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HB370_RS11120 ENOG4105CSH Transporter HB370_RS11140 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HB370_RS11145 ENOG4105BZU Histidine kinase HB370_RS11150 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HB370_RS11155 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HB370_RS11165 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HB370_RS11170 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HB370_RS11180 ENOG4105D7N magnesium and cobalt transport protein CorA HB370_RS11195 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HB370_RS11200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HB370_RS11240 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HB370_RS11250 ENOG4105K5X acetyltransferase HB370_RS11260 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HB370_RS11265 ENOG4105DRR Transcriptional regulator, GntR family HB370_RS11280 ENOG4108D32 Methyltransferase HB370_RS11295 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HB370_RS11305 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HB370_RS11310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HB370_RS11315 ENOG4105CQ7 ATP-dependent helicase HB370_RS11355 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HB370_RS11365 ENOG4105C32 Amino acid ABC transporter (Permease) HB370_RS11370 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HB370_RS11380 ENOG4108IV0 ABC, transporter HB370_RS11405 ENOG4105CGH 5'-nucleotidase HB370_RS11420 ENOG4105ECR NmrA family HB370_RS11430 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HB370_RS11455 ENOG4105CHU acetyl-coa acetyltransferase HB370_RS11460 ENOG4108RZE Tetr family transcriptional regulator HB370_RS11480 ENOG4107S5I aldo keto reductase HB370_RS11490 ENOG4105CBC glutamate synthase HB370_RS11510 ENOG4108RVA ribokinase HB370_RS11525 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HB370_RS11530 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HB370_RS11535 ENOG4105DK0 Indole-3-glycerol phosphate synthase HB370_RS11555 ENOG4105CRQ synthase (Component I) HB370_RS11560 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HB370_RS11580 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HB370_RS11585 ENOG4108176 endoribonuclease L-psp HB370_RS11590 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HB370_RS11595 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HB370_RS11605 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HB370_RS11610 ENOG4105CIH Imidazole acetol-phosphate transaminase HB370_RS11615 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HB370_RS11635 ENOG4108Z66 YbaK ebsC protein HB370_RS11665 ENOG4105C0B DNA polymerase III (alpha subunit) HB370_RS11705 ENOG41082BV acetyltransferase HB370_RS11715 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HB370_RS11725 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HB370_RS11730 ENOG4107VQS DivIVA family HB370_RS11740 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HB370_RS11745 ENOG4105DFA alanine racemase domain protein HB370_RS11750 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HB370_RS11755 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HB370_RS11765 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HB370_RS11775 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HB370_RS11780 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HB370_RS11790 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HB370_RS11795 ENOG4105CJN penicillin-binding protein HB370_RS11805 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HB370_RS11815 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HB370_RS11835 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HB370_RS11845 ENOG4107Z3H Transcriptional regulator, TetR family HB370_RS11870 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HB370_RS11900 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HB370_RS11910 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HB370_RS11925 ENOG4108UQY Iron-storage protein HB370_RS11935 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HB370_RS11955 ENOG4105CTQ phosphohexokinase HB370_RS11965 ENOG4105ENE Histidine kinase HB370_RS11990 ENOG4105DKQ ROK family HB370_RS12000 ENOG4105D0U Arsenite-activated ATPase (ArsA) HB370_RS12020 ENOG4105JNK Glycosyl transferase (Group 1 HB370_RS12035 ENOG4105ZXU NLP P60 protein HB370_RS12065 ENOG4105C9B Cysteine desulfurase HB370_RS12070 ENOG4108I0Q anthranilate phosphoribosyltransferase HB370_RS12075 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HB370_RS12080 ENOG4107EUI c reductase, iron-sulfur HB370_RS12085 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HB370_RS12095 ENOG4105C7K acetolactate synthase HB370_RS12115 ENOG4105CIH Imidazole acetol-phosphate transaminase HB370_RS12120 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HB370_RS12125 ENOG4106A3M Cytochrome p-450 HB370_RS12130 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HB370_RS12135 ENOG4107EUI c reductase, iron-sulfur HB370_RS12140 ENOG4107UDY cytochrome C HB370_RS12145 ENOG4105CCU oxidase (Subunit III) HB370_RS12155 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HB370_RS12160 ENOG4105MCD Part of cytochrome c oxidase, its function is HB370_RS12165 ENOG4105BZ9 Cytochrome C oxidase, subunit I HB370_RS12170 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HB370_RS12180 ENOG4107T4Z adenosine kinase HB370_RS12200 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HB370_RS12210 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS12215 ENOG4105BZU Histidine kinase HB370_RS12240 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HB370_RS12245 ENOG4105C0H protease HB370_RS12255 ENOG4108YZT Adenosylcobinamide kinase HB370_RS12265 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HB370_RS12270 ENOG4105CRK lysyL-tRNA synthetase HB370_RS12290 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HB370_RS12310 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HB370_RS12355 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HB370_RS12360 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HB370_RS12385 ENOG4105KTE polyketide synthesis cyclase HB370_RS12395 ENOG41079R3 acyl carrier protein HB370_RS12400 ENOG4108PDG Beta-ketoacyl synthase HB370_RS12415 ENOG4105PEJ SchA CurD domain protein HB370_RS12430 ENOG4105C5F glutamine synthetase HB370_RS12440 ENOG4105D0M Protease HtpX homolog HB370_RS12465 ENOG4108222 arsenate reductase HB370_RS12470 ENOG4107R5B glutamine synthetase HB370_RS12475 ENOG4107NHD transcriptional regulator HB370_RS12490 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS12525 ENOG41060BG Tetr family transcriptional regulator HB370_RS12545 ENOG4105CG3 alpha amylase, catalytic region HB370_RS12550 ENOG4105EG2 ABC transporter, permease HB370_RS12555 ENOG4105D56 permease protein HB370_RS12565 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS12575 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HB370_RS12585 ENOG4105FBN Acid phosphatase HB370_RS12600 ENOG4105CXN decarboxylase HB370_RS12605 ENOG4105C5F glutamine synthetase HB370_RS12630 ENOG4107ZXU DSBA oxidoreductase HB370_RS12635 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HB370_RS12655 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HB370_RS12660 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS12690 ENOG41081JD Transcriptional regulator HB370_RS12710 ENOG4108VQR secreted hydrolase HB370_RS12760 ENOG4108JGH Tetr family transcriptional regulator HB370_RS12765 ENOG4105F27 Major Facilitator HB370_RS12780 ENOG4105C57 major facilitator superfamily HB370_RS12785 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HB370_RS12825 ENOG4107XZ0 Peptidase M50 HB370_RS12870 ENOG410650H (LipO)protein HB370_RS12875 ENOG4105DBE peroxidase HB370_RS12885 ENOG4106A0S HB370_RS12905 ENOG4107S1E Beta-lactamase HB370_RS12910 ENOG4105C2C drug resistance transporter, Bcr CflA HB370_RS12930 ENOG4105CPC Aldo Keto reductase HB370_RS12935 ENOG4108VGI doxx family HB370_RS12940 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HB370_RS12945 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HB370_RS12955 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS12980 ENOG4105D9P serine threonine protein kinase HB370_RS13005 ENOG4105D9P serine threonine protein kinase HB370_RS13010 ENOG4108DT4 serine threonine protein kinase HB370_RS13050 ENOG4105ENA helicase HB370_RS13110 ENOG4107XFJ UPF0246 protein HB370_RS13115 ENOG4108UHU Aldolase HB370_RS13130 ENOG4105EGD dinuclear metal center protein, YbgI family HB370_RS13170 ENOG4108S01 response regulator HB370_RS13200 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase HB370_RS13230 ENOG4107QVI Methyltransferase, type 11 HB370_RS13235 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HB370_RS13240 ENOG4108SGK Tetr family transcriptional regulator HB370_RS13300 ENOG4108JJB ABC transporter HB370_RS13315 ENOG4105XPP Protein of unknown function (DUF1275) HB370_RS13365 ENOG4105CSH Transporter HB370_RS13465 ENOG41068SY HB370_RS13475 ENOG4105BZ4 penicillin-binding protein HB370_RS13490 ENOG4105DAX Pfam:DUF2983 HB370_RS13535 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HB370_RS13540 ENOG4105EYW Ion transport protein HB370_RS13570 ENOG4108FN7 Aldo keto reductase HB370_RS13575 ENOG4105VUF Transcriptional regulator HB370_RS13605 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HB370_RS13610 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HB370_RS13630 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HB370_RS13635 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HB370_RS13640 ENOG4105N14 lysine exporter protein LysE YggA HB370_RS13645 ENOG4105EXN Sulfate transport protein CysZ HB370_RS13655 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HB370_RS13660 ENOG4108ZHJ Organic hydroperoxide resistance protein HB370_RS13670 ENOG4105CXK mandelate racemase muconate lactonizing HB370_RS13685 ENOG4105DFW ABC transporter HB370_RS13695 ENOG4108HWW ABC transporter HB370_RS13700 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HB370_RS13725 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS13730 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HB370_RS13790 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HB370_RS13795 ENOG4105J4Q Transcriptional regulator HB370_RS13815 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS13820 ENOG4105D8K carboxyl transferase HB370_RS13860 ENOG4105DFF Rod shape-determining protein mreb HB370_RS13890 ENOG4107QTZ amino acid HB370_RS13965 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS13970 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HB370_RS13980 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HB370_RS13990 ENOG4107GZ4 SanA protein HB370_RS13995 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HB370_RS14025 ENOG4105KVH Transcriptional regulator HB370_RS14040 ENOG4107QZF nitrite reductase NADPH large subunit HB370_RS14050 ENOG4108IND Tetr family transcriptional regulator HB370_RS14055 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HB370_RS14060 ENOG4105DRS transport system, permease HB370_RS14065 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HB370_RS14070 ENOG4107FKK extracellular solute-binding protein family 1 HB370_RS14085 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HB370_RS14090 ENOG4105E2R ROK family HB370_RS14155 ENOG4108FN7 Aldo keto reductase HB370_RS14165 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HB370_RS14170 ENOG4105DSE periplasmic solute binding protein HB370_RS14175 ENOG4105FDK ABC transporter HB370_RS14190 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HB370_RS14195 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HB370_RS14210 ENOG4105DEF Extracellular solute-binding protein, family 5 HB370_RS14220 ENOG4105C3U ABC transporter HB370_RS14225 ENOG4108JQ7 (ABC) transporter HB370_RS14230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB370_RS14235 ENOG4108KPJ rna polymerase sigma factor HB370_RS14240 ENOG4108478 ec 3.2.1.18 HB370_RS14250 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HB370_RS14260 ENOG4105D4Y metalloprotease HB370_RS14275 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HB370_RS14295 ENOG4105MSB protein, conserved in bacteria HB370_RS14305 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HB370_RS14320 ENOG4105EQX glucarate dehydratase HB370_RS14330 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HB370_RS14335 ENOG4107YU2 histidine triad (hIT) protein HB370_RS14340 ENOG4107RE3 peptidase, S41 HB370_RS14355 ENOG4105EA8 2-Nitropropane dioxygenase HB370_RS14360 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HB370_RS14365 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HB370_RS14400 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HB370_RS14410 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HB370_RS14425 ENOG4108YYC ycei family HB370_RS14435 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HB370_RS14440 ENOG4105EPR degv family HB370_RS14450 ENOG4105C8T Leucyl-tRNA synthetase HB370_RS14460 ENOG4107QIZ NADH dehydrogenase HB370_RS14490 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HB370_RS14495 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HB370_RS14505 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HB370_RS14520 ENOG4105D0M Protease HtpX homolog HB370_RS14535 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HB370_RS14545 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HB370_RS14555 ENOG4105CG5 Glycosyl transferase (Group 1 HB370_RS14560 ENOG4107SJB teichoic acid biosynthesis HB370_RS14565 ENOG4107SJB teichoic acid biosynthesis HB370_RS14575 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HB370_RS14580 ENOG4105K46 50S ribosomal protein l27 HB370_RS14585 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HB370_RS14590 ENOG4108MDK Dehydrogenase HB370_RS14600 ENOG4105C03 ribonuclease HB370_RS14630 ENOG4105CNI cell division protein FtsW HB370_RS14635 ENOG4105CJN penicillin-binding protein HB370_RS14650 ENOG4105DFF Rod shape-determining protein mreb HB370_RS14655 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HB370_RS14665 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HB370_RS14670 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HB370_RS14680 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HB370_RS14685 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HB370_RS14690 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HB370_RS14695 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HB370_RS14715 ENOG4108TGC Acyltransferase HB370_RS14750 ENOG4105C85 amino acid HB370_RS14760 ENOG4105C85 amino acid HB370_RS14765 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HB370_RS14770 ENOG4105MC2 DSBA oxidoreductase HB370_RS14785 ENOG4108TCJ secreted hydrolase HB370_RS14810 ENOG4105F27 Major Facilitator HB370_RS14815 ENOG4106NZI LysR family Transcriptional regulator HB370_RS14830 ENOG4105EVZ LysR family transcriptional regulator HB370_RS14860 ENOG4105D8X mechanosensitive ion channel HB370_RS14875 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HB370_RS14880 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HB370_RS14885 ENOG4105F8D glycoside hydrolase family 4 HB370_RS14900 ENOG4105CT1 (ABC) transporter HB370_RS14930 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HB370_RS14975 ENOG4105CZE histidine utilization repressor HB370_RS15060 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HB370_RS15070 ENOG4105VHU single-stranded DNA-binding protein HB370_RS15105 ENOG4105C5I Dehydrogenase HB370_RS15150 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HB370_RS15165 ENOG4105CJR Integral membrane protein (MviN HB370_RS15175 ENOG4108KMV Glycosyl transferase (Group 1 HB370_RS15195 ENOG4105CAY ferredoxin--nadp reductase HB370_RS15200 ENOG4105S2J secreted protein HB370_RS15225 ENOG4105CJ1 ABC, transporter HB370_RS15235 ENOG4105C26 Dehydrogenase HB370_RS15240 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HB370_RS15245 ENOG4105DH8 myo-inositol catabolism HB370_RS15255 ENOG4105EDK PfkB domain protein HB370_RS15285 ENOG4105C7H Helicase, RecD TraA family HB370_RS15325 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS15330 ENOG4105C2J ABC transporter HB370_RS15335 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HB370_RS15340 ENOG4108RVA ribokinase HB370_RS15345 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HB370_RS15350 ENOG4105CN8 Transcriptional regulator HB370_RS15360 ENOG4105KNA -acetyltransferase HB370_RS15390 ENOG4108Z40 Transcriptional regulator HB370_RS15395 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HB370_RS15405 ENOG41082YX Transcriptional regulator, arsr family HB370_RS15445 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS15470 ENOG4105D17 glycoside hydrolase, family 3 domain protein HB370_RS15505 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HB370_RS15515 ENOG4105F27 Major Facilitator HB370_RS15520 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HB370_RS15545 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HB370_RS15570 ENOG4105C7K acetolactate synthase HB370_RS15580 ENOG4105CK7 Sodium proline symporter HB370_RS15590 ENOG4108XFF HB370_RS15600 ENOG4105C29 acyl-CoA thioesterase HB370_RS15615 ENOG4107QX3 carboxylase HB370_RS15625 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HB370_RS15630 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS15650 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HB370_RS15660 ENOG4105DUU IucA IucC family protein HB370_RS15665 ENOG4105E2D ec 3.2.1.52 HB370_RS15685 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HB370_RS15710 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HB370_RS15720 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS15745 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS15765 ENOG4106UDK Cellulose-binding, family II HB370_RS15770 ENOG4105BZU Histidine kinase HB370_RS15785 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HB370_RS15800 ENOG4108ZM9 phosphoglycerate mutase HB370_RS15825 ENOG4105DEN Luciferase family HB370_RS15830 ENOG4105BZU Histidine kinase HB370_RS15895 ENOG4108M1A Chitin-binding protein HB370_RS15915 ENOG41073TP transcriptional regulator HB370_RS15945 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HB370_RS15950 ENOG4108MP3 ABC transporter, permease HB370_RS15955 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HB370_RS15965 ENOG4105MWK D-amino acid dehydrogenase, small subunit HB370_RS15970 ENOG41080U6 GntR family transcriptional regulator HB370_RS15980 ENOG4105E2R ROK family HB370_RS15985 ENOG4105D9R oxidoreductase HB370_RS15990 ENOG41090KN UPF0303 protein HB370_RS16005 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HB370_RS16045 ENOG4108PJD permease HB370_RS16060 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HB370_RS16070 ENOG41087EV Hsp20/alpha crystallin family HB370_RS16090 ENOG4105C54 Major Facilitator superfamily HB370_RS16095 ENOG4106BRA Membrane HB370_RS16100 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HB370_RS16130 ENOG4105BZ4 penicillin-binding protein HB370_RS16145 ENOG4108IUW ABC transporter HB370_RS16155 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HB370_RS16205 ENOG4105C85 amino acid HB370_RS16215 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HB370_RS16225 ENOG4108RWI nicotinamidase HB370_RS16260 ENOG4105KF0 sporulation and cell division protein, SsgA HB370_RS16265 ENOG4105CQB FAD linked oxidase domain protein HB370_RS16275 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HB370_RS16335 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HB370_RS16350 ENOG4105E2D ec 3.2.1.52 HB370_RS16360 ENOG4108UJU UPF0301 protein HB370_RS16365 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HB370_RS16370 ENOG4108426 dNA-binding protein HB370_RS16380 ENOG4105EEM helicase HB370_RS16405 ENOG4105DQQ Major facilitator superfamily MFS_1 HB370_RS16415 ENOG4106NZI LysR family Transcriptional regulator HB370_RS16430 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HB370_RS16435 ENOG4105CN1 protease HB370_RS16440 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HB370_RS16445 ENOG4105CAK Cell division ATP-binding protein ftsE HB370_RS16460 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HB370_RS16465 ENOG4108QVN serine threonine protein kinase HB370_RS16470 ENOG4108UGD Serine Threonine protein kinase HB370_RS16475 ENOG4105EC2 ftsk spoIIIe HB370_RS16490 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HB370_RS16495 ENOG4107SJB teichoic acid biosynthesis HB370_RS16500 ENOG4107SJB teichoic acid biosynthesis HB370_RS16505 ENOG4108ZHJ Organic hydroperoxide resistance protein HB370_RS16510 ENOG4105K56 Transcriptional regulator HB370_RS16545 ENOG4105EY8 ABC transporter HB370_RS16550 ENOG4107SJB teichoic acid biosynthesis HB370_RS16555 ENOG4105K64 Glycosyl transferase, family 2 HB370_RS16565 ENOG4105C7I Dehydrogenase HB370_RS16590 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HB370_RS16600 ENOG4105T0Z Conserved Protein HB370_RS16605 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS16610 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HB370_RS16620 ENOG4105G3P Lipoprotein lpqB HB370_RS16625 ENOG4105BZU Histidine kinase HB370_RS16630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HB370_RS16645 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HB370_RS16715 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HB370_RS16730 ENOG4108WQ6 secreted protein HB370_RS16735 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HB370_RS16775 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HB370_RS16795 ENOG4105EIP mannose-6-phosphate isomerase HB370_RS16805 ENOG4105W49 UPF0434 protein HB370_RS16830 ENOG4107RGC Glycosyl transferase, family 2 HB370_RS16835 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HB370_RS16850 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HB370_RS16860 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HB370_RS16875 ENOG4107TB5 TRANSCRIPTIONal HB370_RS16885 ENOG4107TB5 TRANSCRIPTIONal HB370_RS16905 ENOG4108KGH TRANSCRIPTIONal HB370_RS16920 ENOG4105C6Y Udp-glucose 6-dehydrogenase HB370_RS16965 ENOG41065SU Two-component system sensor kinase HB370_RS16970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HB370_RS16975 ENOG4105DUX Transporter HB370_RS16990 ENOG41082AN stage II sporulation protein HB370_RS16995 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS17000 ENOG4105CI2 imidazolone-5-propionate hydrolase HB370_RS17015 ENOG4105CGP Urocanate hydratase HB370_RS17065 ENOG4107GJV short-chain dehydrogenase reductase HB370_RS17085 ENOG4105CHU acetyl-coa acetyltransferase HB370_RS17120 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB370_RS17125 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB370_RS17130 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HB370_RS17135 ENOG4105CEP NADH dehydrogenase HB370_RS17155 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HB370_RS17170 ENOG4106A3M Cytochrome p-450 HB370_RS17245 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB370_RS17250 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB370_RS17255 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS17285 ENOG4105BZU Histidine kinase HB370_RS17300 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HB370_RS17305 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HB370_RS17310 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HB370_RS17315 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HB370_RS17325 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HB370_RS17335 ENOG41067SE Tetr family transcriptional regulator HB370_RS17345 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HB370_RS17350 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HB370_RS17355 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS17365 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HB370_RS17405 ENOG4105C5H ABC transporter HB370_RS17415 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HB370_RS17420 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HB370_RS17430 ENOG4105F8V Hydrolase, tatD family HB370_RS17465 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HB370_RS17475 ENOG4108JJB ABC transporter HB370_RS17490 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HB370_RS17510 ENOG4105EYF MMPL domain protein HB370_RS17530 ENOG4108R85 Short chain dehydrogenase HB370_RS17535 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HB370_RS17540 ENOG4105F95 Monooxygenase HB370_RS17550 ENOG4105CGK Exodeoxyribonuclease III HB370_RS17555 ENOG4105VEV -acetyltransferase HB370_RS17570 ENOG4105D9U N-acetyltransferase HB370_RS17575 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HB370_RS17580 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HB370_RS17590 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HB370_RS17595 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HB370_RS17610 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS17620 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HB370_RS17630 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HB370_RS17645 ENOG4105KXX peptidase s58 dmpa HB370_RS17650 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HB370_RS17665 ENOG4105DM4 PTS System HB370_RS17675 ENOG410804X Transcriptional regulator HB370_RS17700 ENOG4108Z7F N-acetyltransferase HB370_RS17705 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HB370_RS17730 ENOG4107HP6 Transcriptional regulator HB370_RS17790 ENOG4108V06 Glutathione peroxidase HB370_RS17840 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HB370_RS17900 ENOG4108762 serine threonine protein kinase HB370_RS17920 ENOG4105F7P transcriptional regulator AsnC family HB370_RS17925 ENOG4105N14 lysine exporter protein LysE YggA HB370_RS17940 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HB370_RS17955 ENOG4105H3G oxidoreductase HB370_RS17965 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HB370_RS17970 ENOG4105D2S major facilitator superfamily HB370_RS17975 ENOG4105ECQ AraC Family Transcriptional Regulator HB370_RS18015 ENOG41082AN stage II sporulation protein HB370_RS18060 ENOG4108SU4 UPF0309 protein HB370_RS18070 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HB370_RS18085 ENOG4108IG5 Transcriptional regulator HB370_RS18095 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS18110 ENOG4107QX3 carboxylase HB370_RS18125 ENOG4105C6K Malic enzyme HB370_RS18130 ENOG4107AQZ Membrane HB370_RS18135 ENOG4105CQB FAD linked oxidase domain protein HB370_RS18140 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HB370_RS18180 ENOG410834F Transcriptional regulator HB370_RS18185 ENOG4105CHR reductase HB370_RS18195 ENOG4106R7G Glycoside hydrolase family 5 HB370_RS18225 ENOG4105CPC Aldo Keto reductase HB370_RS18250 ENOG4105C7N Xanthine uracil vitamin C permease HB370_RS18260 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HB370_RS18295 ENOG4108N0W Major Facilitator superfamily HB370_RS18305 ENOG4108UIH futalosine nucleosidase HB370_RS18310 ENOG4105E63 Pfam:DUF178 HB370_RS18315 ENOG4105VEQ Cold shock protein HB370_RS18345 ENOG4105CFI type iii restriction protein res subunit HB370_RS18360 ENOG4105EEM helicase HB370_RS18370 ENOG4106N3A copper homeostasis protein cutc HB370_RS18395 ENOG4105QEK Transcriptional regulator HB370_RS18400 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HB370_RS18420 ENOG4107QQG Dehydrogenase HB370_RS18425 ENOG4107QJZ Glycosyl transferase, family 2 HB370_RS18440 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HB370_RS18445 ENOG4105VEQ Cold shock protein HB370_RS18460 ENOG4105C3Q Glycosyl transferase, family 2 HB370_RS18490 ENOG4105CE4 GlcNAc 6-P deacetylase HB370_RS18495 ENOG4105DE4 1-phosphofructokinase HB370_RS18505 ENOG4105BZU Histidine kinase HB370_RS18525 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HB370_RS18675 ENOG4105C2N RNA methyltransferase TrmH family group 3 HB370_RS18680 ENOG4105C8N cysteinyl-tRNA synthetase HB370_RS18685 ENOG410905P Pyridoxamine 5-phosphate HB370_RS18690 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HB370_RS18695 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HB370_RS18700 ENOG4108VJ1 Transcriptional regulator (CarD family HB370_RS18720 ENOG4105BZU Histidine kinase HB370_RS18755 ENOG4105CHR reductase HB370_RS18800 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HB370_RS18830 ENOG4108YZJ Pfam:DUF2596 HB370_RS18835 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HB370_RS18875 ENOG41061H0 Monooxygenase HB370_RS18905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HB370_RS18915 ENOG4105YIP Tetr family transcriptional regulator HB370_RS18925 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HB370_RS18930 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HB370_RS18935 ENOG41090R7 Ferric uptake HB370_RS18940 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HB370_RS18980 ENOG4105KHC sulfurtransferase HB370_RS18985 ENOG4105PKJ carbohydrate binding HB370_RS19030 ENOG4107NHD transcriptional regulator HB370_RS19035 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS19040 ENOG4105C0H protease HB370_RS19050 ENOG4105ETX regulatoR HB370_RS19065 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HB370_RS19070 ENOG4105DBA pectate lyase HB370_RS19115 ENOG4105CGH 5'-nucleotidase HB370_RS19120 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HB370_RS19135 ENOG4105CIG ABC transporter HB370_RS19150 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HB370_RS19180 ENOG4105VPX protein, conserved in bacteria HB370_RS19195 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HB370_RS19215 ENOG4105DNP FAD linked oxidase domain protein HB370_RS19220 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HB370_RS19225 ENOG4105K4H Nlp p60 protein HB370_RS19330 ENOG4105D5U fad dependent oxidoreductase HB370_RS19335 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HB370_RS19345 ENOG4105CPC Aldo Keto reductase HB370_RS19360 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HB370_RS19370 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HB370_RS19375 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS19410 ENOG4105C1J atp-dependent rna helicase HB370_RS19460 ENOG4105CQ7 ATP-dependent helicase HB370_RS19480 ENOG4108TAC HB370_RS19495 ENOG4105CXB phosphoribosylaminoimidazole synthetase HB370_RS19515 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HB370_RS19520 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HB370_RS19525 ENOG410839H phosphoribosylformylglycinamidine synthase HB370_RS19570 ENOG4105C8V SAICAR synthetase HB370_RS19590 ENOG4105C12 Phosphoribosylglycinamide synthetase HB370_RS19610 ENOG4107T65 Integrase HB370_RS19615 ENOG4106CY5 excisionase HB370_RS19705 ENOG4108T5E Copper resistance protein HB370_RS19710 ENOG4105CHR reductase HB370_RS19740 ENOG4105D7A ATP-binding protein HB370_RS19755 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HB370_RS19770 ENOG4108Z6B deaminase HB370_RS19785 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HB370_RS19790 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS19795 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS19805 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HB370_RS19815 ENOG4108YYC ycei family HB370_RS19820 ENOG410905P Pyridoxamine 5-phosphate HB370_RS19830 ENOG4105C57 major facilitator superfamily HB370_RS19835 ENOG4105EDW glycosyl transferase, family 39 HB370_RS19845 ENOG4105BZU Histidine kinase HB370_RS19850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HB370_RS19905 ENOG4106CY5 excisionase HB370_RS19945 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS19950 ENOG4105NAF rna polymerase sigma factor HB370_RS20000 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HB370_RS20020 ENOG4107T6F Xaa-Pro aminopeptidase HB370_RS20065 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HB370_RS20070 ENOG410667J hydrolase HB370_RS20115 ENOG410667J hydrolase HB370_RS20120 ENOG4108JJ9 ABC, transporter HB370_RS20125 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HB370_RS20130 ENOG4105C4M (Ubiquinol oxidase) subunit I HB370_RS20140 ENOG4105CIH Imidazole acetol-phosphate transaminase HB370_RS20145 ENOG4107P2S Transcriptional regulator HB370_RS20150 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HB370_RS20160 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HB370_RS20185 ENOG4106048 Cupin 2, conserved barrel domain protein HB370_RS20190 ENOG41082T9 Membrane HB370_RS20195 ENOG4105KJF protein tyrosine phosphatase HB370_RS20200 ENOG4105C28 cystathionine HB370_RS20230 ENOG4105F27 Major Facilitator HB370_RS20255 ENOG4105CDU Replicative dna helicase HB370_RS20265 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HB370_RS20270 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HB370_RS20275 ENOG4107YH6 single-stranded DNA-binding protein HB370_RS20280 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HB370_RS20305 ENOG4105BZ4 penicillin-binding protein HB370_RS20325 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HB370_RS20340 ENOG4105D9P serine threonine protein kinase HB370_RS20355 ENOG4105C3M thioredoxin reductase HB370_RS20360 ENOG4105K63 Thioredoxin HB370_RS20375 ENOG4107QJE Chromosome Partitioning Protein HB370_RS20380 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HB370_RS20390 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HB370_RS20395 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HB370_RS20400 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HB370_RS20405 ENOG41084CH 50S ribosomal protein l34 HB370_RS20415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HB370_RS20420 ENOG4108J5G 6-phosphogluconate dehydrogenase HB370_RS20425 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HB370_RS20430 ENOG4105K7N UPF0232 protein HB370_RS20435 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB370_RS20440 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB370_RS20465 ENOG410905P Pyridoxamine 5-phosphate HB370_RS20470 ENOG4108HMN Caspase domain HB370_RS20505 ENOG4108UGD Serine Threonine protein kinase HB370_RS20535 ENOG4105CHR reductase HB370_RS20540 ENOG4105F27 Major Facilitator HB370_RS20545 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HB370_RS20570 ENOG4105ZJT Cell division protein CrgA HB370_RS20595 ENOG4108U4N (sortase) family HB370_RS20600 ENOG4108RN7 integral membrane protein HB370_RS20610 ENOG4105CJN penicillin-binding protein HB370_RS20625 ENOG4105HZM Fha domain containing protein HB370_RS20630 ENOG4105TV9 FHA Domain-Containing protein HB370_RS20670 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HB370_RS20675 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HB370_RS20680 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HB370_RS20685 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HB370_RS20690 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HB370_RS20715 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB370_RS20720 ENOG4108IG5 Transcriptional regulator HB370_RS20740 ENOG4107QSN dihydrolipoamide acetyltransferase HB370_RS20745 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HB370_RS20775 ENOG4107QPV Serine Threonine protein kinase HB370_RS20795 ENOG4105CPP Dehydrogenase, E1 component HB370_RS20800 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HB370_RS20830 ENOG4107QNK )-transporter HB370_RS20850 ENOG4105ECQ AraC Family Transcriptional Regulator HB370_RS20875 ENOG4105DFM M18 family aminopeptidase HB370_RS20880 ENOG4105CSU acyl-Coa dehydrogenase HB370_RS20895 ENOG4105EUB pirin domain protein HB370_RS20940 ENOG4105VBF alkaline shock protein HB370_RS20945 ENOG4108WQI RNA Polymerase HB370_RS20965 ENOG4105C9M aspartyl-trna synthetase HB370_RS20975 ENOG4108J20 pectate lyase HB370_RS20980 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HB370_RS20990 ENOG4105EM2 membrane HB370_RS20995 ENOG4105F2Z 3-oxoadipate enol-lactonase HB370_RS21000 ENOG4107U9B transcriptional regulator HB370_RS21040 ENOG4105CG3 alpha amylase, catalytic region HB370_RS21045 ENOG41066UM arsR family transcriptional regulator HB370_RS21050 ENOG4105D9G High-affinity HB370_RS21055 ENOG4105DHU Bile acid HB370_RS21070 ENOG4105C22 threonyL-tRNA synthetase HB370_RS21090 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HB370_RS21115 ENOG4105BZ9 Cytochrome C oxidase, subunit I HB370_RS21125 ENOG4105NAF rna polymerase sigma factor HB370_RS21135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS21150 ENOG4105C1J atp-dependent rna helicase HB370_RS21155 ENOG4105VEQ Cold shock protein HB370_RS21265 ENOG4105F0K SARP family transcriptional regulator HB370_RS21300 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HB370_RS21305 ENOG4105C5Q Transcriptional regulator HB370_RS21330 ENOG4105DUM transcriptional regulator, lysR family HB370_RS21365 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HB370_RS21370 ENOG4107T4Z adenosine kinase HB370_RS21395 ENOG4105C1J atp-dependent rna helicase HB370_RS21400 ENOG4105VEQ Cold shock protein HB370_RS21425 ENOG4107MMM Anti-sigma-factor antagonist HB370_RS21435 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HB370_RS21450 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS21530 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HB370_RS21545 ENOG4107SBK Acetylornithine deacetylase HB370_RS21550 ENOG4107TJV N-acetylglutamate semialdehyde dehydrogenase HB370_RS21565 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HB370_RS21585 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HB370_RS21615 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS21625 ENOG4105EYF MMPL domain protein HB370_RS21640 ENOG4105DHP deoxycytidine triphosphate deaminase HB370_RS21645 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HB370_RS21660 ENOG4105DF6 Fe-S oxidoreductase HB370_RS21670 ENOG4105CFG Acts as a chaperone (By similarity) HB370_RS21675 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HB370_RS21680 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HB370_RS21685 ENOG4105KNI merR family transcriptional Regulator HB370_RS21690 ENOG4105DFW ABC transporter HB370_RS21715 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HB370_RS21740 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HB370_RS21755 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HB370_RS21780 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HB370_RS21800 ENOG4105BZU Histidine kinase HB370_RS21805 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS21820 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HB370_RS21830 ENOG4108WYP Transcriptional regulator HB370_RS21835 ENOG4108JPW Aminotransferase HB370_RS21850 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HB370_RS21855 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HB370_RS21865 ENOG4105CFH Aspartokinase HB370_RS21940 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HB370_RS21965 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HB370_RS21975 ENOG4105YVS arsR family transcriptional regulator HB370_RS21980 ENOG4108RWP Major Facilitator Superfamily protein HB370_RS22015 ENOG4105KTE polyketide synthesis cyclase HB370_RS22025 ENOG4105CZS beta-ketoacyl synthase HB370_RS22050 ENOG4107SCK Monooxygenase HB370_RS22060 ENOG4105D8K carboxyl transferase HB370_RS22070 ENOG4108JIK carboxylase HB370_RS22080 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HB370_RS22245 ENOG4105DFU Cell wall formation (By similarity) HB370_RS22275 ENOG4105GFG DUF218 domain HB370_RS22395 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HB370_RS22425 ENOG4105D74 hydrolase HB370_RS22440 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HB370_RS22500 ENOG4108I5C dEAD DEAH box helicase HB370_RS22505 ENOG4105WN5 stage II sporulation protein HB370_RS22515 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HB370_RS22535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HB370_RS22540 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HB370_RS22550 ENOG4106JDR secreted HB370_RS22580 ENOG4105C2M dna polymerase I HB370_RS22600 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HB370_RS22605 ENOG4105KDC 50s ribosomal protein l28 HB370_RS22615 ENOG4105NRA 50s ribosomal protein l31 type b HB370_RS22625 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HB370_RS22645 ENOG4105C26 Dehydrogenase HB370_RS22660 ENOG4107TXC Transcriptional regulator HB370_RS22665 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HB370_RS22675 ENOG4105F0N pyrophosphate phospho-hydrolase HB370_RS22690 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HB370_RS22695 ENOG4108UGV hypoxanthine phosphoribosyltransferase HB370_RS22705 ENOG4105EUJ GTP cyclohydrolase i HB370_RS22715 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HB370_RS22735 ENOG4105CRK lysyL-tRNA synthetase HB370_RS22760 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS22775 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS22800 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HB370_RS22805 ENOG4108IYU L-aspartate oxidase HB370_RS22815 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HB370_RS22870 ENOG4105DR5 peptidase HB370_RS22875 ENOG4108IG5 Transcriptional regulator HB370_RS22885 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HB370_RS22890 ENOG4108FKE two-component system sensor kinase HB370_RS22895 ENOG4108PYU two-component system response regulator HB370_RS22900 ENOG41075QH Lipoprotein CseA HB370_RS22905 ENOG4105NAF rna polymerase sigma factor HB370_RS22920 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HB370_RS22935 ENOG4108JWX HB370_RS22940 ENOG4107R33 ppx gppa phosphatase HB370_RS22945 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HB370_RS22950 ENOG4105PF9 Transcriptional regulator HB370_RS22955 ENOG4105C01 Dihydroxy-acid dehydratase HB370_RS22965 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HB370_RS22980 ENOG4105II7 pyrroline-5-carboxylate reductase HB370_RS22985 ENOG4105C31 Tryptophanyl-tRNA synthetase HB370_RS23005 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HB370_RS23015 ENOG4106UW1 Major Facilitator superfamily HB370_RS23020 ENOG4105DGU Histone deacetylase HB370_RS23070 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HB370_RS23075 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HB370_RS23080 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HB370_RS23085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HB370_RS23090 ENOG4105D52 delta-aminolevulinic acid dehydratase HB370_RS23150 ENOG4105C75 arginyL-tRNA synthetase HB370_RS23155 ENOG4105DK7 lysyl-tRNA synthetase HB370_RS23175 ENOG4105E0Y RtcB Protein HB370_RS23195 ENOG4105KK4 UPF0060 membrane protein HB370_RS23200 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HB370_RS23205 ENOG4108UZX fmn reductase HB370_RS23215 ENOG41062D9 Histidine kinase HB370_RS23230 ENOG4108ME1 Peptidase M55 D-aminopeptidase HB370_RS23245 ENOG4107R11 Transcriptional regulator HB370_RS23250 ENOG4108KTG Membrane protein, drug metabolite transporter HB370_RS23255 ENOG4108UW5 maltose o-acetyltransferase HB370_RS23275 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HB370_RS23280 ENOG4105XTG Pfam:DUF156 HB370_RS23285 ENOG4108VCT Sulfite exporter TauE/SafE HB370_RS23295 ENOG4107TPS domain protein HB370_RS23310 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HB370_RS23315 ENOG4108RH7 phosphoglycerate mutase HB370_RS23330 ENOG4107QIV Cytochrome c biogenesis protein HB370_RS23335 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HB370_RS23340 ENOG4105CRE cytochrome C HB370_RS23365 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HB370_RS23375 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HB370_RS23380 ENOG4105EW9 transcriptional regulator AsnC family HB370_RS23385 ENOG4105DVY radical SAM domain protein HB370_RS23390 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HB370_RS23405 ENOG4108R86 Transcriptional regulator HB370_RS23460 ENOG4105VEQ Cold shock protein HB370_RS23465 ENOG4105EV6 Pfam:DUF178 HB370_RS23475 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HB370_RS23485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HB370_RS23500 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HB370_RS23515 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23520 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HB370_RS23525 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23535 ENOG4107QIZ NADH dehydrogenase HB370_RS23540 ENOG4108IEH NADH dehydrogenase subunit g HB370_RS23545 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HB370_RS23550 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23560 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23565 ENOG4105D65 subunit l HB370_RS23575 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23585 ENOG4105C9U ATP-dependent DNA helicase RecQ HB370_RS23600 ENOG410667J hydrolase HB370_RS23620 ENOG4105CJ1 ABC, transporter HB370_RS23645 ENOG4105ECR NmrA family HB370_RS23650 ENOG4105KVH Transcriptional regulator HB370_RS23655 ENOG4105DQU oxidoreductase, subunit beta HB370_RS23660 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HB370_RS23680 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HB370_RS23685 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23690 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HB370_RS23695 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HB370_RS23700 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23705 ENOG4107YX3 NADH dehydrogenase subunit j HB370_RS23710 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23715 ENOG4105D65 subunit l HB370_RS23720 ENOG4105C8S subunit m HB370_RS23725 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HB370_RS23730 ENOG4105D0M Protease HtpX homolog HB370_RS23735 ENOG410901E Membrane HB370_RS23745 ENOG4105Y3U Transglycosylase-associated protein HB370_RS23750 ENOG4108VPT UPF0234 protein HB370_RS23785 ENOG4105DZC cytosine deaminase HB370_RS23800 ENOG4105WDJ 50S ribosomal protein L33 HB370_RS23805 ENOG410900P UPF0336 protein HB370_RS23815 ENOG4107R4N Cell wall formation (By similarity) HB370_RS23830 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HB370_RS23850 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HB370_RS23860 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HB370_RS23865 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HB370_RS23885 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HB370_RS23890 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HB370_RS23895 ENOG4108K0D peptidase, M48 HB370_RS23925 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HB370_RS23930 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HB370_RS23935 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HB370_RS24055 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HB370_RS24060 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HB370_RS24065 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HB370_RS24070 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HB370_RS24075 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HB370_RS24080 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HB370_RS24085 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HB370_RS24090 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HB370_RS24095 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HB370_RS24100 ENOG41082SA 50s ribosomal protein l29 HB370_RS24105 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HB370_RS24110 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HB370_RS24115 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HB370_RS24120 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HB370_RS24125 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HB370_RS24135 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HB370_RS24140 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HB370_RS24145 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HB370_RS24150 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HB370_RS24155 ENOG410849U 50S ribosomal protein L30 HB370_RS24160 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HB370_RS24170 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HB370_RS24185 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HB370_RS24190 ENOG41067V7 50S ribosomal protein L36 HB370_RS24195 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HB370_RS24200 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HB370_RS24205 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HB370_RS24210 ENOG4108ZT0 50S ribosomal protein l17 HB370_RS24215 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HB370_RS24235 ENOG4105C6Y Udp-glucose 6-dehydrogenase HB370_RS24240 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HB370_RS24250 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HB370_RS24255 ENOG4108UJD 30S ribosomal protein S9 HB370_RS24260 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HB370_RS24270 ENOG4105CS9 pantothenic acid kinase HB370_RS24285 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HB370_RS24290 ENOG4105CHR reductase HB370_RS24305 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HB370_RS24315 ENOG4108097 ATP-binding protein HB370_RS24335 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HB370_RS24345 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS24350 ENOG4107TB5 TRANSCRIPTIONal HB370_RS24360 ENOG4105CHP RNA polymerase HB370_RS24385 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HB370_RS24395 ENOG4105EMU Dehydrogenase HB370_RS24405 ENOG4105DND Transcriptional regulator HB370_RS24410 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HB370_RS24420 ENOG4108MMM RNA Polymerase HB370_RS24430 ENOG4107QVP Dehydrogenase HB370_RS24435 ENOG4107QQG Dehydrogenase HB370_RS24440 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HB370_RS24450 ENOG4105D9P serine threonine protein kinase HB370_RS24455 ENOG4107TPY serine threonine protein kinase HB370_RS24460 ENOG4108UGD Serine Threonine protein kinase HB370_RS24465 ENOG4105C26 Dehydrogenase HB370_RS24480 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HB370_RS24515 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS24530 ENOG4105CAT Cytidine monophosphate kinase HB370_RS24545 ENOG4105DR5 peptidase HB370_RS24570 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HB370_RS24575 ENOG4105RD5 HB370_RS24580 ENOG4105DEG Vwa containing coxe family protein HB370_RS24585 ENOG4105CMV Succinyl-CoA synthetase subunit beta HB370_RS24615 ENOG4105DC1 bifunctional purine biosynthesis protein purh HB370_RS24625 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HB370_RS24640 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HB370_RS24650 ENOG4105C57 major facilitator superfamily HB370_RS24675 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component HB370_RS24690 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HB370_RS24695 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HB370_RS24700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HB370_RS24710 ENOG4106032 Glutathionylspermidine synthase HB370_RS24725 ENOG4105C8Y Acetylornithine aminotransferase HB370_RS24730 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HB370_RS24735 ENOG4105C31 Tryptophanyl-tRNA synthetase HB370_RS24750 ENOG4107H3J ribonuclease HB370_RS24770 ENOG4105U5Y Transcriptional regulator HB370_RS24795 ENOG4108J01 L-aspartate oxidase HB370_RS24815 ENOG4105E2D ec 3.2.1.52 HB370_RS24840 ENOG4108MMM RNA Polymerase HB370_RS24860 ENOG4108NIW Leucine export protein LeuE HB370_RS24875 ENOG4105K64 Glycosyl transferase, family 2 HB370_RS24890 ENOG4105K64 Glycosyl transferase, family 2 HB370_RS24900 ENOG4105F0R Cytidylyltransferase HB370_RS24905 ENOG4105D2T synthase HB370_RS24915 ENOG4107RM1 amidohydrolase HB370_RS24920 ENOG4105DIH basic membrane HB370_RS24925 ENOG4108JQ9 ABC transporter HB370_RS24930 ENOG4105UIB (ABC) transporter HB370_RS24965 ENOG4105D94 Major Facilitator Superfamily HB370_RS24970 ENOG4107RSM transcriptional regulator HB370_RS24985 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HB370_RS25010 ENOG41065SU Two-component system sensor kinase HB370_RS25015 ENOG4108KXV response regulator HB370_RS25020 ENOG4105NAF rna polymerase sigma factor HB370_RS25035 ENOG4105C26 Dehydrogenase HB370_RS25040 ENOG4105C26 Dehydrogenase HB370_RS25055 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HB370_RS25075 ENOG4105E98 transcriptional regulator DeoR family HB370_RS25080 ENOG4108JIK carboxylase HB370_RS25090 ENOG4107WR6 Maf-like protein HB370_RS25100 ENOG4105D8K carboxyl transferase HB370_RS25110 ENOG4108QER Adenylate cyclase HB370_RS25115 ENOG4105E39 Enoyl-CoA hydratase HB370_RS25120 ENOG4105KDM Diguanylate cyclase with gaf sensor HB370_RS25125 ENOG4105C84 Histidine ammonia-lyase HB370_RS25170 ENOG4105DQ4 alcohol dehydrogenase HB370_RS25180 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HB370_RS25190 ENOG4105D0M Protease HtpX homolog HB370_RS25215 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HB370_RS25220 ENOG4105C7B Threonine dehydratase HB370_RS25235 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HB370_RS25245 ENOG4105T1M mycothiol conjugate amidase mca HB370_RS25255 ENOG4105C7Z Conserved Protein HB370_RS25270 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HB370_RS25280 ENOG4105CHM Aminotransferase HB370_RS25315 ENOG4108FUF Transcriptional regulator, IclR family HB370_RS25320 ENOG4105KME endoribonuclease L-psp HB370_RS25325 ENOG4105C6Z Gluconate HB370_RS25370 ENOG4105CNA YD repeat protein HB370_RS25435 ENOG4105BZU Histidine kinase HB370_RS25475 ENOG4105F2W methyltransferase HB370_RS25480 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HB370_RS25485 ENOG4108IAB Phoh family HB370_RS25490 ENOG4106770 Is able to cleave peptidoglycan (By similarity) HB370_RS25500 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HB370_RS25505 ENOG4105D3R alkyl hydroperoxide reductase HB370_RS25520 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HB370_RS25540 ENOG4105BZ4 penicillin-binding protein HB370_RS25555 ENOG4105C9Q fumarate hydratase class II HB370_RS25565 ENOG4107GFK fumarate HB370_RS25595 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HB370_RS25600 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HB370_RS25605 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HB370_RS25615 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HB370_RS25630 ENOG4105C3G gtp-binding protein HB370_RS25665 ENOG4105CHR reductase HB370_RS25680 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HB370_RS25700 ENOG4105C3M thioredoxin reductase HB370_RS25715 ENOG4108S01 response regulator HB370_RS25720 ENOG4105BZU Histidine kinase HB370_RS25770 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS25780 ENOG4107RB3 L-asparaginase HB370_RS25815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB370_RS25825 ENOG4105DBV ornithine carbamoyltransferase HB370_RS25895 ENOG4105E33 succinate dehydrogenase HB370_RS25920 ENOG4105CI3 gtp-binding protein typa HB370_RS25925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS25930 ENOG4108J59 Extracellular solute-binding protein, family 5 HB370_RS25945 ENOG4108JQ7 (ABC) transporter HB370_RS25950 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HB370_RS25955 ENOG4108JQ7 (ABC) transporter HB370_RS25975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS25985 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HB370_RS25990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS25995 ENOG4105C3U ABC transporter HB370_RS26000 ENOG4108JQ7 (ABC) transporter HB370_RS26030 ENOG4108M15 ABC transporter HB370_RS26040 ENOG4105BZU Histidine kinase HB370_RS26045 ENOG4108S01 response regulator HB370_RS26060 ENOG4108Z4U Ferredoxin HB370_RS26080 ENOG4107R4C succinyl-diaminopimelate desuccinylase HB370_RS26085 ENOG4108URH decarboxylase HB370_RS26090 ENOG4105EEI dihydropteroate synthase HB370_RS26100 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HB370_RS26105 ENOG4105CGU Enoyl-CoA hydratase HB370_RS26120 ENOG4105DU6 RNA polymerase HB370_RS26140 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HB370_RS26175 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HB370_RS26185 ENOG4105D7N magnesium and cobalt transport protein CorA HB370_RS26195 ENOG4105DXB Major Facilitator superfamily HB370_RS26210 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HB370_RS26230 ENOG4105C1J atp-dependent rna helicase HB370_RS26280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS26290 ENOG4108JQ6 ABC transporter HB370_RS26355 ENOG4105C4R Atp-dependent dna helicase HB370_RS26360 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HB370_RS26365 ENOG4105E09 nadh pyrophosphatase HB370_RS26385 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HB370_RS26450 ENOG41063PX domain protein HB370_RS26460 ENOG4105DJZ UPF0182 protein HB370_RS26495 ENOG4107TK4 histidinol-phosphate phosphatase HB370_RS26505 ENOG4105KPY Small multidrug resistance protein HB370_RS26515 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HB370_RS26525 ENOG4108RAV Conserved protein HB370_RS26535 ENOG4105EMN RNA polymerase sigma factor HB370_RS26540 ENOG4105WMN AntiSigma factor HB370_RS26545 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HB370_RS26560 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HB370_RS26570 ENOG41068W2 Cytochrome p-450 HB370_RS26585 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HB370_RS26590 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HB370_RS26610 ENOG4105FDP GntR family transcriptional regulator HB370_RS26615 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HB370_RS26620 ENOG4105CHR reductase HB370_RS26640 ENOG4105CBD Diacylglycerol kinase HB370_RS26655 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HB370_RS26685 ENOG4105ESN nucleotide-binding protein HB370_RS26710 ENOG4108VEQ Superoxide dismutase HB370_RS26725 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HB370_RS26730 ENOG4105CDA abc transporter atp-binding protein HB370_RS26745 ENOG4105C6K Malic enzyme HB370_RS26750 ENOG4105CB2 alcohol dehydrogenase HB370_RS26780 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HB370_RS26785 ENOG4105EB3 Histidine kinase HB370_RS26790 ENOG4108PYU two-component system response regulator HB370_RS26800 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HB370_RS26855 ENOG4105K4H Nlp p60 protein HB370_RS26895 ENOG4108FKE two-component system sensor kinase HB370_RS26915 ENOG4105DQE DNA ligase HB370_RS26920 ENOG4105FDF Could be involved in DNA repair (By similarity) HB370_RS26930 ENOG4105YVS arsR family transcriptional regulator HB370_RS26955 ENOG4105C75 arginyL-tRNA synthetase HB370_RS26960 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HB370_RS26965 ENOG4105D6E homoserine dehydrogenase HB370_RS26970 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HB370_RS26975 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HB370_RS26985 ENOG4108KGH TRANSCRIPTIONal HB370_RS26990 ENOG4105VFB Binds the 23S rRNA (By similarity) HB370_RS26995 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HB370_RS27000 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HB370_RS27010 ENOG4107ZF2 Phosphatase HB370_RS27015 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HB370_RS27020 ENOG4105ESV Glycosyl transferase, family 4 HB370_RS27025 ENOG4105Z3P ATP synthase HB370_RS27035 ENOG4105ZA1 atp synthase HB370_RS27040 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HB370_RS27045 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HB370_RS27050 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HB370_RS27055 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HB370_RS27060 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HB370_RS27065 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HB370_RS27080 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS27085 ENOG4105BZU Histidine kinase HB370_RS27110 ENOG410630P Transcriptional regulator HB370_RS27115 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB370_RS27130 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HB370_RS27175 ENOG4105CHU acetyl-coa acetyltransferase HB370_RS27250 ENOG4105WX6 Membrane HB370_RS27290 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HB370_RS27295 ENOG4105C6K Malic enzyme HB370_RS27300 ENOG4105CTQ phosphohexokinase HB370_RS27310 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HB370_RS27315 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HB370_RS27325 ENOG4108MRH transcriptional regulatory protein HB370_RS27335 ENOG4107QJT sodium dicarboxylate symporter HB370_RS27345 ENOG4105C57 major facilitator superfamily HB370_RS27365 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HB370_RS27370 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HB370_RS27380 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HB370_RS27385 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HB370_RS27405 ENOG4105BZ1 (ABC) transporter HB370_RS27410 ENOG4105BZ1 (ABC) transporter HB370_RS27460 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HB370_RS27490 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HB370_RS27500 ENOG4105UPE Enoyl-CoA hydratase HB370_RS27525 ENOG4105DKW ABC transporter HB370_RS27530 ENOG4107SNV Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HB370_RS27540 ENOG4105E7U AraC family transcriptional regulator HB370_RS27550 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HB370_RS27575 ENOG4105EJQ L-serine dehydratase HB370_RS27580 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HB370_RS27585 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HB370_RS27590 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HB370_RS27610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS27640 ENOG4105EN6 Membrane HB370_RS27645 ENOG4108SEA Esterase HB370_RS27660 ENOG4105D29 Helix-turn-helix type 11 domain protein HB370_RS27690 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HB370_RS27705 ENOG4108URH decarboxylase HB370_RS27710 ENOG4105EMU Dehydrogenase HB370_RS27720 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HB370_RS27725 ENOG4105BZU Histidine kinase HB370_RS27735 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HB370_RS27740 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HB370_RS27750 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HB370_RS27765 ENOG4105D9U N-acetyltransferase HB370_RS27780 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS27795 ENOG4105CPC Aldo Keto reductase HB370_RS27820 ENOG4108ZP8 Acetolactate synthase small subunit HB370_RS27825 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HB370_RS27830 ENOG4108JQ1 Dehydrogenase HB370_RS27835 ENOG4105C57 major facilitator superfamily HB370_RS27850 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HB370_RS27860 ENOG4105C26 Dehydrogenase HB370_RS27870 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HB370_RS27875 ENOG4105CM2 brancheD-chain amino acid aminotransferase HB370_RS27890 ENOG4105CQM Urea amidohydrolase subunit alpha HB370_RS27895 ENOG4105DWY Agmatine deiminase HB370_RS27900 ENOG4108RF4 Tetr family transcriptional regulator HB370_RS27905 ENOG4105CSH Transporter HB370_RS27910 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HB370_RS27960 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS27965 ENOG4105BZU Histidine kinase HB370_RS27975 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HB370_RS27980 ENOG4108YYC ycei family HB370_RS27990 ENOG4106AM8 polysaccharide lyase family 8 HB370_RS27995 ENOG4105D8K carboxyl transferase HB370_RS28020 ENOG4105GWZ Roadblock lc7 family protein HB370_RS28040 ENOG4105GWZ Roadblock lc7 family protein HB370_RS28055 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HB370_RS28060 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HB370_RS28105 ENOG41069M3 Transcriptional regulator HB370_RS28110 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HB370_RS28115 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HB370_RS28125 ENOG4105K70 DNA-binding protein HB370_RS28145 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HB370_RS28150 ENOG4105CPF Cell wall formation (By similarity) HB370_RS28170 ENOG4105DWF phosphomethylpyrimidine kinase HB370_RS28175 ENOG4105VB9 50S ribosomal protein l28 HB370_RS28180 ENOG4105DP4 dak2 domain fusion protein ylov HB370_RS28200 ENOG4106H78 methyltransferase HB370_RS28205 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HB370_RS28220 ENOG41084BZ 50S ribosomal protein L32 HB370_RS28225 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HB370_RS28230 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HB370_RS28235 ENOG4105KVH Transcriptional regulator HB370_RS28240 ENOG4105CS1 NAD(P)H quinone oxidoreductase HB370_RS28250 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HB370_RS28265 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HB370_RS28310 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HB370_RS28320 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HB370_RS28335 ENOG4105K5M 30s ribosomal protein S16 HB370_RS28340 ENOG41082KU UPF0109 protein HB370_RS28345 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HB370_RS28350 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HB370_RS28355 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HB370_RS28370 ENOG4107QYR Signal peptidase i HB370_RS28375 ENOG4107QYR Signal peptidase i HB370_RS28390 ENOG41080R2 UPF0102 protein HB370_RS28405 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS28415 ENOG41063SB peptidase HB370_RS28420 ENOG4105CE9 30S ribosomal protein S2 HB370_RS28425 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HB370_RS28430 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HB370_RS28435 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HB370_RS28440 ENOG4105KNE Phosphatidate cytidylyltransferase HB370_RS28445 ENOG4106A3M Cytochrome p-450 HB370_RS28450 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HB370_RS28460 ENOG4105ECW sulfate abc transporter HB370_RS28465 ENOG4108UCS ABC, transporter HB370_RS28480 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HB370_RS28485 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HB370_RS28495 ENOG4105C26 Dehydrogenase HB370_RS28500 ENOG4108FN7 Aldo keto reductase HB370_RS28520 ENOG4107HP6 Transcriptional regulator HB370_RS28540 ENOG4105KVH Transcriptional regulator HB370_RS28550 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HB370_RS28555 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HB370_RS28580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HB370_RS28585 ENOG4105F38 ABC transporter, permease HB370_RS28590 ENOG4105D38 putrescine abc transporter HB370_RS28595 ENOG4105CJP fad dependent oxidoreductase HB370_RS28625 ENOG4105G9B Transcriptional regulator HB370_RS28630 ENOG4105C26 Dehydrogenase HB370_RS28650 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HB370_RS28665 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HB370_RS28705 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HB370_RS28710 ENOG4105DZP Membrane-associated zinc metalloprotease HB370_RS28715 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HB370_RS28755 ENOG4108Z7F N-acetyltransferase HB370_RS28760 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HB370_RS28765 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HB370_RS28785 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HB370_RS28800 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HB370_RS28810 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HB370_RS28815 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HB370_RS28850 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HB370_RS28925 ENOG4105EC2 ftsk spoIIIe HB370_RS28945 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HB370_RS28950 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HB370_RS28955 ENOG4105C1V Peptidase, M16 HB370_RS28960 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HB370_RS28980 ENOG4107V6K Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HB370_RS28985 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB370_RS28990 ENOG4105CN5 Metallo-Beta-Lactamase HB370_RS29030 ENOG4105BZU Histidine kinase HB370_RS29035 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HB370_RS29050 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HB370_RS29060 ENOG4105CEV competence damage-inducible protein HB370_RS29065 ENOG4105WBV Transcriptional regulator HB370_RS29070 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HB370_RS29080 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HB370_RS29085 ENOG4107QRT dEAD DEAH box helicase HB370_RS29115 ENOG4105DSF transport protein HB370_RS29155 ENOG4105DRP amino acid AbC transporter HB370_RS29160 ENOG4108Q1T ABC transporter HB370_RS29165 ENOG4107UBR Extracellular solute-binding protein family 3 HB370_RS29170 ENOG4105CDA abc transporter atp-binding protein HB370_RS29175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HB370_RS29180 ENOG4105EB3 Histidine kinase HB370_RS29215 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HB370_RS29220 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS29240 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HB370_RS29255 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HB370_RS29265 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HB370_RS29275 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HB370_RS29285 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HB370_RS29320 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HB370_RS29325 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HB370_RS29330 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HB370_RS29345 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HB370_RS29365 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HB370_RS29380 ENOG4105C9U ATP-dependent DNA helicase RecQ HB370_RS29405 ENOG4105DRR Transcriptional regulator, GntR family HB370_RS29410 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB370_RS29425 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB370_RS29440 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS29445 ENOG4108MRH transcriptional regulatory protein HB370_RS29450 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HB370_RS29460 ENOG4105BZN citrate synthase HB370_RS29465 ENOG4105CKI cobalamin synthesis protein HB370_RS29470 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB370_RS29490 ENOG4105DRR Transcriptional regulator, GntR family HB370_RS29495 ENOG410849S phosphocarrier protein (HPr) HB370_RS29505 ENOG4105CD5 CoA-binding domain protein HB370_RS29520 ENOG4107W53 thymidine kinase HB370_RS29555 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HB370_RS29570 ENOG4105F44 Two component transcriptional regulator, winged helix family HB370_RS29575 ENOG4106F60 Histidine kinase HB370_RS29600 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HB370_RS29615 ENOG410836F Transposase HB370_RS29645 ENOG4107VEG TrkA-N domain protein HB370_RS29650 ENOG4105C0X amino acid HB370_RS29655 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HB370_RS29665 ENOG4108IND Tetr family transcriptional regulator HB370_RS29700 ENOG4107R6F Alpha Beta Hydrolase Fold protein HB370_RS29735 ENOG4105YVS arsR family transcriptional regulator HB370_RS29760 ENOG4107XWI flavin reductase domain protein, FMN-binding HB370_RS29775 ENOG4105EW9 transcriptional regulator AsnC family HB370_RS29780 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HB370_RS29855 ENOG4108UQS dipeptidase HB370_RS29860 ENOG4105CPF Cell wall formation (By similarity) HB370_RS29880 ENOG4106F60 Histidine kinase HB370_RS29885 ENOG4105F44 Two component transcriptional regulator, winged helix family HB370_RS29890 ENOG4105CX8 fg-gap repeat protein HB370_RS29985 ENOG4107S1Q Phosphatase HB370_RS30030 ENOG4105CEU Arginine dihydrolase HB370_RS30035 ENOG4105DBV ornithine carbamoyltransferase HB370_RS30040 ENOG4105CUB amino acid HB370_RS30060 ENOG4105FDP GntR family transcriptional regulator HB370_RS30080 ENOG4105D17 glycoside hydrolase, family 3 domain protein HB370_RS30145 ENOG4108NA0 Uncharacterized conserved protein (COG2071) HB370_RS30160 ENOG4107HP6 Transcriptional regulator HB370_RS30175 ENOG4105F27 Major Facilitator HB370_RS30190 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HB370_RS30195 ENOG4108R85 Short chain dehydrogenase HB370_RS30200 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HB370_RS30215 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HB370_RS30220 ENOG4105DRS transport system, permease HB370_RS30225 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HB370_RS30240 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS30260 ENOG4108M1A Chitin-binding protein HB370_RS30265 ENOG4105II7 pyrroline-5-carboxylate reductase HB370_RS30280 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HB370_RS30300 ENOG4107QM5 aconitate hydratase HB370_RS30305 ENOG4105CB2 alcohol dehydrogenase HB370_RS30345 ENOG4105E2R ROK family HB370_RS30350 ENOG4105DFW ABC transporter HB370_RS30355 ENOG4105C2J ABC transporter HB370_RS30360 ENOG4108HWW ABC transporter HB370_RS30365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HB370_RS30370 ENOG4105CUB amino acid HB370_RS30375 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HB370_RS30390 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB370_RS30395 ENOG4105CHU acetyl-coa acetyltransferase HB370_RS30400 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HB370_RS30425 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HB370_RS30435 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HB370_RS30445 ENOG4107JTW chlorite dismutase HB370_RS30460 ENOG4105E18 UPF0276 protein HB370_RS30465 ENOG4105MXW flavin reductase domain protein, FMN-binding HB370_RS30475 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS30485 ENOG4105CAQ asparagine synthetase HB370_RS30510 ENOG4105C57 major facilitator superfamily HB370_RS30515 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HB370_RS30520 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HB370_RS30545 ENOG41064MX Tetr family transcriptional regulator HB370_RS30565 ENOG4105FDK ABC transporter HB370_RS30600 ENOG4107B2H carbonic anhydrase HB370_RS30625 ENOG4105DFU Cell wall formation (By similarity) HB370_RS30630 ENOG4105E0X reductase HB370_RS30635 ENOG4108IJ8 ABC transporter HB370_RS30640 ENOG4105E90 ABC transporter HB370_RS30645 ENOG4105E90 ABC transporter HB370_RS30660 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HB370_RS30670 ENOG41064MX Tetr family transcriptional regulator HB370_RS30685 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HB370_RS30800 ENOG4105E90 ABC transporter HB370_RS30805 ENOG4105D7T ABC transporter HB370_RS30835 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HB370_RS30850 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HB370_RS30860 ENOG4107RR1 TRANSCRIPTIONal HB370_RS30865 ENOG4105CSU acyl-Coa dehydrogenase HB370_RS30910 ENOG4105CR4 methylisocitrate lyase HB370_RS30925 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS30930 ENOG4108Z6Z Transcriptional regulator HB370_RS30940 ENOG4105EBR Carboxylesterase HB370_RS30945 ENOG4108J5H Homocysteine s-methyltransferase HB370_RS30965 ENOG4107TDE lipolytic protein G-D-S-L family HB370_RS31000 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HB370_RS31020 ENOG4105QE3 oxidoreductase HB370_RS31035 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HB370_RS31050 ENOG4105EWC Purine nucleoside phosphorylase HB370_RS31090 ENOG4105C7K acetolactate synthase HB370_RS31110 ENOG4105DRR Transcriptional regulator, GntR family HB370_RS31130 ENOG4105C7N Xanthine uracil vitamin C permease HB370_RS31140 ENOG4108ZJ4 polysaccharide deacetylase HB370_RS31150 ENOG4107Q25 Serine Threonine protein kinase HB370_RS31165 ENOG4105EPJ extracellular solute-binding protein family 1 HB370_RS31170 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HB370_RS31180 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HB370_RS31185 ENOG4105CPQ Dehydrogenase HB370_RS31190 ENOG4107QP3 malate synthase g HB370_RS31210 ENOG4105F27 Major Facilitator HB370_RS31215 ENOG4107RDP Dehydrogenase HB370_RS31225 ENOG41060W2 glyoxylate carboligase HB370_RS31235 ENOG4105CH6 catalase HB370_RS31240 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HB370_RS31245 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HB370_RS31265 ENOG4105VT2 5-hydroxyisourate hydrolase HB370_RS31275 ENOG4105C2W permease HB370_RS31280 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HB370_RS31305 ENOG4108ZM9 phosphoglycerate mutase HB370_RS31320 ENOG4105CHM Aminotransferase HB370_RS31340 ENOG4105DUU IucA IucC family protein HB370_RS31355 ENOG4107VIJ nudix hydrolase HB370_RS31365 ENOG4105E98 transcriptional regulator DeoR family HB370_RS31375 ENOG4108KPJ rna polymerase sigma factor HB370_RS31400 ENOG4107R9S Malate synthase HB370_RS31405 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HB370_RS31420 ENOG4105J4Q Transcriptional regulator HB370_RS31430 ENOG4105DHG Allantoate amidinohydrolase HB370_RS31455 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS31460 ENOG4105FDP GntR family transcriptional regulator HB370_RS31470 ENOG41062B0 ABC transporter, permease HB370_RS31475 ENOG4105C2J ABC transporter HB370_RS31480 ENOG4105DKQ ROK family HB370_RS31490 ENOG4105C0D helicase HB370_RS31515 ENOG41064MX Tetr family transcriptional regulator HB370_RS31535 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HB370_RS31545 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS31585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HB370_RS31605 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HB370_RS31665 ENOG4108K6T Protein of unknown function (DUF1205) HB370_RS31670 ENOG4108K6T Protein of unknown function (DUF1205) HB370_RS31705 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HB370_RS31740 ENOG4105CHR reductase HB370_RS31765 ENOG4105CDA abc transporter atp-binding protein HB370_RS31775 ENOG4105EAD ABC transporter HB370_RS31780 ENOG4105DRP amino acid AbC transporter HB370_RS31785 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HB370_RS31790 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HB370_RS31810 ENOG4105C8Y Acetylornithine aminotransferase HB370_RS31820 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HB370_RS31825 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HB370_RS31845 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HB370_RS31850 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HB370_RS31855 ENOG4105ECY inositol monophosphatase HB370_RS31885 ENOG4105DAE Methylenetetrahydrofolate reductase HB370_RS31900 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HB370_RS31920 ENOG4105BZW Glycerate kinase HB370_RS31930 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HB370_RS31935 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS31945 ENOG4105CI0 Citrate lyase HB370_RS31965 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB370_RS31980 ENOG4106JDR secreted HB370_RS32025 ENOG4105CHR reductase HB370_RS32035 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HB370_RS32045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HB370_RS32050 ENOG4105EWK phytoene HB370_RS32055 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS32060 ENOG4105BZU Histidine kinase HB370_RS32090 ENOG4105CPC Aldo Keto reductase HB370_RS32095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HB370_RS32105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HB370_RS32110 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HB370_RS32115 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HB370_RS32120 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HB370_RS32125 ENOG4105CHR reductase HB370_RS32130 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HB370_RS32135 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HB370_RS32140 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HB370_RS32155 ENOG4108JIK carboxylase HB370_RS32170 ENOG4108Q50 Histidine kinase HB370_RS32175 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HB370_RS32180 ENOG4108ME1 Peptidase M55 D-aminopeptidase HB370_RS32185 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HB370_RS32195 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HB370_RS32225 ENOG4105CV1 Transketolase (EC 2.2.1.1) HB370_RS32240 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HB370_RS32265 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HB370_RS32275 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HB370_RS32300 ENOG4105GCF PGAM HB370_RS32305 ENOG4105C5H ABC transporter HB370_RS32360 ENOG4105E8R UPF0173 metal-dependent hydrolase HB370_RS32390 ENOG4108IUE nitrate reductase beta subunit HB370_RS32415 ENOG4106GCT Dehydratase HB370_RS32420 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HB370_RS32435 ENOG4105CYP glycoside hydrolase, family HB370_RS32440 ENOG41065HY 1,4-beta-cellobiosidase HB370_RS32445 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HB370_RS32465 ENOG4105CV8 reductase HB370_RS32485 ENOG4105DUM transcriptional regulator, lysR family HB370_RS32490 ENOG4105DHU Bile acid HB370_RS32495 ENOG4108478 ec 3.2.1.18 HB370_RS32510 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HB370_RS32515 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HB370_RS32555 ENOG4108IG5 Transcriptional regulator HB370_RS32575 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HB370_RS32585 ENOG4108RZ2 Glycoside hydrolase family 16 HB370_RS32595 ENOG4105DZS Phenylacetate-CoA ligase HB370_RS32620 ENOG4105C01 Dihydroxy-acid dehydratase HB370_RS32625 ENOG4108Z0R Transferase HB370_RS32630 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HB370_RS32645 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS32650 ENOG4108Z0R Transferase HB370_RS32665 ENOG4108IPT Naphthoate synthase HB370_RS32670 ENOG4105CC9 acyl-Coa dehydrogenase HB370_RS32675 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS32680 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HB370_RS32690 ENOG4107YCY Transcriptional regulator HB370_RS32700 ENOG4105F27 Major Facilitator HB370_RS32710 ENOG4107RRN ABC transporter substrate-binding protein HB370_RS32715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS32740 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HB370_RS32760 ENOG4107QJN gtp cyclohydrolase ii HB370_RS32785 ENOG410905P Pyridoxamine 5-phosphate HB370_RS32805 ENOG4107QQG Dehydrogenase HB370_RS32815 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HB370_RS32820 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HB370_RS32840 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HB370_RS32845 ENOG4108J5G 6-phosphogluconate dehydrogenase HB370_RS32850 ENOG4107QP8 phosphohexose isomerase HB370_RS32865 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HB370_RS32895 ENOG4108HH4 Major Facilitator Superfamily HB370_RS32910 ENOG4105DU1 integral membrane protein, terc HB370_RS32915 ENOG4105F8D glycoside hydrolase family 4 HB370_RS32925 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS32985 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HB370_RS32995 ENOG4105CG3 alpha amylase, catalytic region HB370_RS33005 ENOG4105CSH Transporter HB370_RS33065 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HB370_RS33070 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HB370_RS33075 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HB370_RS33085 ENOG4105CHU acetyl-coa acetyltransferase HB370_RS33115 ENOG4105DQE DNA ligase HB370_RS33125 ENOG4105EUJ GTP cyclohydrolase i HB370_RS33135 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS33145 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HB370_RS33155 ENOG4106V2I dimethylaminohydrolase HB370_RS33160 ENOG4105C5H ABC transporter HB370_RS33165 ENOG4105KF0 sporulation and cell division protein, SsgA HB370_RS33185 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HB370_RS33190 ENOG4105EG6 Saccharopine dehydrogenase HB370_RS33195 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HB370_RS33200 ENOG4105CHU acetyl-coa acetyltransferase HB370_RS33205 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB370_RS33225 ENOG4108U3T pfkb domain protein HB370_RS33245 ENOG4105C5H ABC transporter HB370_RS33255 ENOG4105BZM domain protein HB370_RS33260 ENOG4105E39 Enoyl-CoA hydratase HB370_RS33270 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HB370_RS33290 ENOG4108MDK Dehydrogenase HB370_RS33310 ENOG4105EY8 ABC transporter HB370_RS33315 ENOG4105FBD synthase HB370_RS33335 ENOG4105EWU Squalene--hopene cyclase HB370_RS33350 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HB370_RS33385 ENOG41090WU lipolytic protein G-D-S-L family HB370_RS33415 ENOG4105EUB pirin domain protein HB370_RS33420 ENOG4107SFI Major Facilitator superfamily HB370_RS33425 ENOG4108VGI doxx family HB370_RS33430 ENOG4105CHJ isochorismatase hydrolase HB370_RS33435 ENOG4105CPN adenine deaminase HB370_RS33485 ENOG4105CPQ Dehydrogenase HB370_RS33490 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HB370_RS33495 ENOG4106NZI LysR family Transcriptional regulator HB370_RS33570 ENOG4105ERH Fumarylacetoacetate hydrolase HB370_RS33585 ENOG41061H0 Monooxygenase HB370_RS33595 ENOG4105ERH Fumarylacetoacetate hydrolase HB370_RS33615 ENOG4105CZS beta-ketoacyl synthase HB370_RS33655 ENOG4108JIK carboxylase HB370_RS33675 ENOG4108S01 response regulator HB370_RS33680 ENOG4105BZU Histidine kinase HB370_RS33695 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HB370_RS33705 ENOG41067TZ transcriptional regulator, MarR family HB370_RS33715 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HB370_RS33720 ENOG4105MXW flavin reductase domain protein, FMN-binding HB370_RS33760 ENOG4108X4Q Hydrolase HB370_RS33780 ENOG4105E5G Alpha beta hydrolase fold HB370_RS33790 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS33905 ENOG4107RN3 metallophosphoesterase HB370_RS33930 ENOG4105DHJ ABC, transporter HB370_RS34020 ENOG4105C3F Signal peptidase i HB370_RS34025 ENOG4105BZ1 (ABC) transporter HB370_RS34065 ENOG4107T94 Endo-14-beta-xylanase HB370_RS34070 ENOG4107T94 Endo-14-beta-xylanase HB370_RS34080 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS34085 ENOG4108JP0 extracellular solute-binding protein family 1 HB370_RS34120 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HB370_RS34125 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HB370_RS34140 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS34180 ENOG4105C4R Atp-dependent dna helicase HB370_RS34225 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HB370_RS34260 ENOG4105EBR Carboxylesterase HB370_RS34320 ENOG4108HRK Histidine kinase HB370_RS34325 ENOG4105D5Q Arginine ornithine antiporter HB370_RS34335 ENOG4105CTU Proline racemase HB370_RS34340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB370_RS34355 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HB370_RS34370 ENOG4105DRP amino acid AbC transporter HB370_RS34375 ENOG4105EAB amino acid AbC transporter HB370_RS34390 ENOG4105DEN Luciferase family HB370_RS34450 ENOG4105E9K Isocitrate dehydrogenase HB370_RS34455 ENOG4105M0C cytoplasmic protein HB370_RS34460 ENOG4105D64 Mechanosensitive ion channel HB370_RS34465 ENOG4105CUB amino acid HB370_RS34475 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HB370_RS34480 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HB370_RS34495 ENOG4105BZ1 (ABC) transporter HB370_RS34500 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HB370_RS34505 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HB370_RS34510 ENOG4105C7W Xanthine dehydrogenase HB370_RS34520 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HB370_RS34535 ENOG4105DRS transport system, permease HB370_RS34540 ENOG4108NEV two component transcriptional regulator, LytTR family HB370_RS34570 ENOG4108IG5 Transcriptional regulator HB370_RS34575 ENOG4105VEQ Cold shock protein HB370_RS34585 ENOG4105ECQ AraC Family Transcriptional Regulator HB370_RS34595 ENOG4108478 ec 3.2.1.18 HB370_RS34625 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HB370_RS34670 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HB370_RS34680 ENOG4108W5M transcriptional regulator HB370_RS34695 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HB370_RS34715 ENOG4105CWX Alpha-1,2-mannosidase HB370_RS34745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HB370_RS34750 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS34755 ENOG4105BZ7 extracellular solute-binding protein family 1 HB370_RS34800 ENOG41073TP transcriptional regulator HB370_RS34805 ENOG4105DIA mandelate racemase muconate lactonizing HB370_RS34860 ENOG4105CUB amino acid HB370_RS34900 ENOG4105BZU Histidine kinase HB370_RS34905 ENOG4107RSM transcriptional regulator HB370_RS34915 ENOG4105C5Q Transcriptional regulator HB370_RS34930 ENOG4105E33 succinate dehydrogenase HB370_RS34945 ENOG4108Z20 Acyl-transferase HB370_RS34960 ENOG4105DEN Luciferase family HB370_RS34970 ENOG4105WKW Pfam:DUF1458 HB370_RS34980 ENOG41067HS methyltransferase HB370_RS34985 ENOG4108V75 Glutamine amidotransferase HB370_RS34990 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HB370_RS35045 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HB370_RS35050 ENOG4107TYH extracellular solute-binding protein family 1 HB370_RS35055 ENOG4105D81 ABC transporter, permease HB370_RS35060 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HB370_RS35065 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HB370_RS35080 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HB370_RS35090 ENOG4105BZ1 (ABC) transporter HB370_RS35120 ENOG41080RH Thioredoxin HB370_RS35125 ENOG4107QN2 dihydrolipoyl dehydrogenase HB370_RS35130 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HB370_RS35145 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein HB370_RS35160 ENOG4108KPJ rna polymerase sigma factor HB370_RS35165 ENOG4106A3M Cytochrome p-450 HB370_RS35170 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB370_RS35175 ENOG41067TZ transcriptional regulator, MarR family HB370_RS35220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HB370_RS35225 ENOG4105E90 ABC transporter HB370_RS35240 ENOG4108IJ8 ABC transporter HB370_RS35245 ENOG41080R8 Conserved Protein HB370_RS35250 ENOG4107QR9 Iron-sulfur cluster binding protein HB370_RS35255 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HB370_RS35260 ENOG4105DET Rhamnulokinase HB370_RS35270 ENOG4105C9F isomerase HB370_RS35280 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HB370_RS35290 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS35300 ENOG4107TXC Transcriptional regulator HB370_RS35310 ENOG4105DDN Pentapeptide repeat-containing protein HB370_RS35315 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HB370_RS35320 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HB370_RS35330 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HB370_RS35350 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HB370_RS35355 ENOG4105E2R ROK family HB370_RS35380 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HB370_RS35385 ENOG4105CFG Acts as a chaperone (By similarity) HB370_RS35415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB370_RS35460 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HB370_RS35465 ENOG4105DCG PHP domain protein HB370_RS35470 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HB370_RS35510 ENOG4105C8S subunit m HB370_RS35535 ENOG4105CHF Glutathione S-transferase HB370_RS35550 ENOG4106YKD Cytochrome p-450 HB370_RS35565 ENOG4105CPC Aldo Keto reductase HB370_RS35585 ENOG4105D9P serine threonine protein kinase HB370_RS35600 ENOG4105CNT hydrolase family 2 HB370_RS35625 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HB370_RS35640 ENOG4105EMU Dehydrogenase HB370_RS35650 ENOG4108ZJ4 polysaccharide deacetylase HB370_RS35665 ENOG4108JJA ABC, transporter HB370_RS35670 ENOG4108JJA ABC, transporter HB370_RS35700 ENOG4106A3M Cytochrome p-450 HB370_RS35720 ENOG41085A6 mbth domain-containing protein HB370_RS35765 ENOG4105CQB FAD linked oxidase domain protein HB370_RS35770 ENOG4105CXK mandelate racemase muconate lactonizing HB370_RS35775 ENOG4108W6C Dehydrogenase HB370_RS35785 ENOG4105CD3 dihydroorotase HB370_RS35820 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HB370_RS35825 ENOG4108NIW Leucine export protein LeuE HB370_RS35860 ENOG4105FDK ABC transporter HB370_RS35875 ENOG4105EWU Squalene--hopene cyclase HB370_RS35905 ENOG4105CHR reductase HB370_RS35910 ENOG4105DY8 decarboxylase HB370_RS35960 ENOG41067SE Tetr family transcriptional regulator HB370_RS35995 ENOG4105DBI uridine monophosphokinase HB370_RS36035 ENOG4105D4M Lactamase_B HB370_RS36045 ENOG4105BZP glycoside hydrolase 15-related HB370_RS36060 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HB370_RS36100 ENOG4108ZBR Gcn5-related n-acetyltransferase HB370_RS36195 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HB370_RS36230 ENOG4105CPC Aldo Keto reductase HB370_RS36250 ENOG4106A3M Cytochrome p-450 HB370_RS36280 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HB370_RS36310 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HB370_RS36325 ENOG4105EGE secreted protein HB370_RS36335 ENOG4105CXN decarboxylase HB370_RS36360 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HB370_RS36365 ENOG4105FUA antagonist HB370_RS36370 ENOG4107MMM Anti-sigma-factor antagonist HB370_RS36380 ENOG4105FDF Could be involved in DNA repair (By similarity) HB370_RS36405 ENOG4105ENE Histidine kinase HB370_RS36410 ENOG4105WH1 Two component transcriptional regulator luxr family HB370_RS36455 ENOG4105CUB amino acid HB370_RS36485 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HB370_RS36525 ENOG4108VQR secreted hydrolase HB370_RS36535 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HB370_RS36595 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HB370_RS36620 ENOG4105C5H ABC transporter HB370_RS36625 ENOG4105CHR reductase HB370_RS36640 ENOG4105EC3 peptidase S51, dipeptidase E HB370_RS36655 ENOG4107R3A FAD linked oxidase domain protein HB370_RS36660 ENOG4107TE5 Lipid kinase HB370_RS36670 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HB370_RS36690 ENOG4107TB5 TRANSCRIPTIONal HB370_RS36705 ENOG41064MX Tetr family transcriptional regulator HB370_RS36710 ENOG4108XEP Alpha Beta Hydrolase Fold protein HB370_RS36720 ENOG4105EYF MMPL domain protein HB370_RS36750 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HB370_RS36765 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HB370_RS36770 ENOG4105J3Q acyl carrier protein HB370_RS36775 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HB370_RS36780 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HB370_RS36785 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HB370_RS36815 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HB370_RS36820 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HB370_RS36825 ENOG4107T4Z adenosine kinase HB370_RS36845 ENOG4108SUT Major Facilitator Superfamily HB370_RS36850 ENOG4105CAQ asparagine synthetase HB370_RS36860 ENOG4108KPJ rna polymerase sigma factor HB370_RS36870 ENOG4108762 serine threonine protein kinase HB370_RS36900 ENOG410880H cysteine synthase HB370_RS36950 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HB370_RS36970 ENOG4105VPX protein, conserved in bacteria HB370_RS37015 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HB370_RS37075 ENOG4105CSA Coproporphyrinogen iii oxidase HB370_RS37095 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HB370_RS37115 ENOG4105D74 hydrolase HB370_RS37120 ENOG4105R1U AraC Family Transcriptional Regulator HB370_RS37130 ENOG4106T9R serine protease HB370_RS37145 ENOG4106T9R serine protease HB370_RS37155 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HB370_RS37170 ENOG4105S7M extracellular small neutral protease HB370_RS37175 ENOG4108KXM LysR family Transcriptional regulator HB370_RS37185 ENOG4105YVS arsR family transcriptional regulator HB370_RS37195 ENOG4105KVH Transcriptional regulator HB370_RS37210 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS37215 ENOG4105DXX methyltransferase HB370_RS37275 ENOG41060M0 Crispr-associated protein, cse4 family HB370_RS37280 ENOG4108VWQ crispr-associated protein HB370_RS37290 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HB370_RS37295 ENOG4105PWE CRISPR-associated protein cas2 HB370_RS37330 ENOG4105FB9 CRISPR-associated protein HB370_RS37350 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HB370_RS37485 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HB370_RS37500 ENOG4105BZU Histidine kinase HB370_RS37520 ENOG4108VGI doxx family HB370_RS37525 ENOG4105CHJ isochorismatase hydrolase HB370_RS37530 ENOG4105CPN adenine deaminase HB370_RS37570 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS37615 ENOG4105DRS transport system, permease HB370_RS37635 ENOG4105E2R ROK family HB370_RS37670 ENOG4105D9U N-acetyltransferase HB370_RS37935 ENOG41068JE domain protein HB370_RS38000 ENOG4105CPF Cell wall formation (By similarity) HB370_RS38075 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HB370_RS38105 ENOG4105GN4 DNA ligase HB370_RS38135 ENOG4105F5W AtP-binding protein HB370_RS38185 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HB370_RS38190 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HB370_RS38195 ENOG4108IQE Amp-dependent synthetase and ligase HB370_RS38200 ENOG4105ECB domain protein HB370_RS38275 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HB370_RS38340 ENOG4107RSM transcriptional regulator HB370_RS38380 ENOG4108I0Q anthranilate phosphoribosyltransferase HB370_RS38385 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HB370_RS38405 ENOG4108IAJ Nad-dependent epimerase dehydratase HB370_RS38415 ENOG4108UW5 maltose o-acetyltransferase HB370_RS38450 ENOG4105DEG Vwa containing coxe family protein HB370_RS38455 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HB370_RS38465 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HB370_RS38480 ENOG4105D5G Transposase HB370_RS38490 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HB370_RS38500 ENOG4105E09 nadh pyrophosphatase HB370_RS38630 ENOG4105BZP glycoside hydrolase 15-related HB370_RS38760 ENOG4107RB3 L-asparaginase HB370_RS38785 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HB370_RS38830 ENOG4105RKW reductase (By HB370_RS38930 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HB370_RS38965 ENOG4108J59 Extracellular solute-binding protein, family 5 HB370_RS38970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB370_RS38980 ENOG4105DWV Homoserine O-trans-acetylase HB370_RS38990 ENOG4105E2B Taurine dioxygenase HB370_RS39000 ENOG4106FTQ Taurine ABC transporter, periplasmic HB370_RS39005 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HB370_RS39015 ENOG4105E2A Dehydrogenase HB370_RS39035 ENOG4107Y2X deaminase HB370_RS39110 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HB370_RS39160 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HB370_RS39165 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HB370_RS39175 ENOG4105FQP Beta-lactamase HB370_RS39195 ENOG4105EV8 ectoine hydroxylase HB370_RS39200 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HB370_RS39220 ENOG4105CHR reductase HB370_RS39225 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HB370_RS39235 ENOG4105BZ8 glutamate synthase HB370_RS39245 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HB370_RS39270 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HB370_RS39280 ENOG4108KPJ rna polymerase sigma factor HB370_RS39330 ENOG4107QM2 Aldo Keto reductase HB370_RS39350 ENOG4105W06 Cupin 2, conserved barrel domain protein HB370_RS39370 ENOG4108U3T pfkb domain protein HB370_RS39375 ENOG4108PVU Nucleotidyl transferase HB370_RS39400 ENOG4105CJ1 ABC, transporter HB370_RS39405 ENOG4108JPW Aminotransferase HB370_RS39450 ENOG4105EG2 ABC transporter, permease HB370_RS39455 ENOG4105CG3 alpha amylase, catalytic region HB370_RS39460 ENOG4105ETE Transcriptional regulator (LacI family HB370_RS39475 ENOG4105C26 Dehydrogenase HB370_RS39485 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB370_RS39500 ENOG4105CJ1 ABC, transporter HB370_RS39550 ENOG41086D8 Transcriptional regulator HB370_RS39610 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HB370_RS39615 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HB370_RS39620 ENOG4105C7W Xanthine dehydrogenase HB370_RS39625 ENOG4105XRQ Xanthine dehydrogenase accessory factor HB370_RS39690 ENOG4105C57 major facilitator superfamily HB370_RS39705 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HB370_RS39730 ENOG4105EX0 alpha-galactosidase HB370_RS39735 ENOG4107SYN Glycosyl hydrolases family 43 HB370_RS39740 ENOG4106R7G Glycoside hydrolase family 5 HB370_RS39810 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HB370_RS39830 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HB370_RS39870 ENOG4106A3M Cytochrome p-450 HB370_RS39890 ENOG4105ENX hydrolase HB370_RS39895 ENOG4105CHR reductase HB370_RS39900 ENOG4108R86 Transcriptional regulator HB370_RS39925 ENOG4105EMN RNA polymerase sigma factor HB370_RS39935 ENOG4108ZHJ Organic hydroperoxide resistance protein HB370_RS40015 ENOG4105CAY ferredoxin--nadp reductase HB370_RS40020 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS40100 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HB370_RS40110 ENOG4107RSM transcriptional regulator HB370_RS40115 ENOG4105FBW Monooxygenase HB370_RS40175 ENOG4105E1F short-chain dehydrogenase reductase HB370_RS40215 ENOG4108R86 Transcriptional regulator HB370_RS40220 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HB370_RS40230 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HB370_RS40325 ENOG4107WDG serine threonine protein kinase HB370_RS40385 ENOG4105CEY Amp-dependent synthetase and ligase HB370_RS40390 ENOG4105C7B Threonine dehydratase HB370_RS40405 ENOG4105DBV ornithine carbamoyltransferase HB370_RS40420 ENOG4108S01 response regulator HB370_RS40470 ENOG4107R37 Glutamate dehydrogenase HB370_RS40490 ENOG4108D32 Methyltransferase HB370_RS40510 ENOG4107T94 Endo-14-beta-xylanase HB370_RS40520 ENOG4108ZJ4 polysaccharide deacetylase HB370_RS40530 ENOG4105C1G acyl-Coa dehydrogenase HB370_RS40535 ENOG4108S8N class II Aldolase HB370_RS40565 ENOG4105CVI Transcriptional regulator HB370_RS40580 ENOG4105NGS secreted protein HB370_RS40610 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HB370_RS40635 ENOG4107QKG PfaD family HB370_RS40645 ENOG4107QJQ Mate efflux family protein HB370_RS40660 ENOG4107R6F Alpha Beta Hydrolase Fold protein HB370_RS40695 ENOG4105D9P serine threonine protein kinase HB370_RS40700 ENOG4105EC2 ftsk spoIIIe HB370_RS40715 ENOG4107RIQ Sulfate adenylate transferase HB370_RS40720 ENOG4105CSR polyphosphate kinase 2 HB370_RS40730 ENOG4105KVH Transcriptional regulator HB370_RS40735 ENOG4105KME endoribonuclease L-psp HB370_RS40760 ENOG4108TCJ secreted hydrolase HB370_RS40810 ENOG4105CYP glycoside hydrolase, family HB370_RS40870 ENOG4105CYP glycoside hydrolase, family HB370_RS40895 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HB370_RS40920 ENOG4105PTV Nudix Hydrolase HB370_RS40925 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HB370_RS40940 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HB370_RS40955 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HB370_RS40970 ENOG4105BZ1 (ABC) transporter HB370_RS41000 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HB370_RS41195 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)