locus-tag	class	description
HB370_RS00125	COG3409	Peptidoglycan-binding domain 1 protein
HB370_RS00190	COG0477	Major facilitator Superfamily
HB370_RS00240	COG4585	Histidine kinase
HB370_RS00245	COG2197	response regulator
HB370_RS00270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB370_RS00275	COG1518	maintenance of DNA repeat elements
HB370_RS00315	COG2226	methyltransferase
HB370_RS00355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB370_RS00360	COG0019	diaminopimelate decarboxylase activity
HB370_RS00375	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HB370_RS00385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HB370_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS00420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS00420	COG3433	isochorismatase activity
HB370_RS00420	COG2226	methyltransferase
HB370_RS00475	COG0596	Alpha beta hydrolase
HB370_RS00510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HB370_RS00575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB370_RS00580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB370_RS00640	COG0477	Major facilitator Superfamily
HB370_RS00665	COG1063	alcohol dehydrogenase
HB370_RS00740	COG0395	ABC-type sugar transport system, permease component
HB370_RS00835	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HB370_RS00900	COG2072	flavoprotein involved in K transport
HB370_RS00905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB370_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS00930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HB370_RS00935	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS00940	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS00955	COG3547	Transposase (IS116 IS110 IS902 family)
HB370_RS00985	COG2124	cytochrome p450
HB370_RS00985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB370_RS01025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB370_RS01035	COG0300	oxidoreductase activity
HB370_RS01180	COG0203	ribosomal protein L17
HB370_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS01220	COG4221	oxidoreductase activity
HB370_RS01225	COG1309	transcriptional regulator
HB370_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS01265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB370_RS01285	COG0596	Alpha beta hydrolase
HB370_RS01330	COG2186	Transcriptional regulator
HB370_RS01335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB370_RS01340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB370_RS01345	COG2828	Protein conserved in bacteria
HB370_RS01355	COG2814	Major facilitator Superfamily
HB370_RS01360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB370_RS01365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB370_RS01370	COG2382	esterase
HB370_RS01375	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HB370_RS01380	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS01385	COG1169	isochorismate synthase
HB370_RS01390	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB370_RS01395	COG1535	isochorismatase
HB370_RS01395	COG3433	isochorismatase activity
HB370_RS01400	COG1535	isochorismatase
HB370_RS01400	COG3433	isochorismatase activity
HB370_RS01405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS01415	COG2091	lysine biosynthetic process via aminoadipic acid
HB370_RS01420	COG2382	esterase
HB370_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS01450	COG0667	Aldo Keto reductase
HB370_RS01460	COG1309	transcriptional regulator
HB370_RS01480	COG1309	transcriptional regulator
HB370_RS01505	COG0300	oxidoreductase activity
HB370_RS01510	COG1309	transcriptional regulator
HB370_RS01515	COG0300	oxidoreductase activity
HB370_RS01560	COG0583	DNA-binding transcription factor activity
HB370_RS01575	COG0604	alcohol dehydrogenase
HB370_RS01660	COG1595	DNA-templated transcription, initiation
HB370_RS01690	COG1278	Cold shock
HB370_RS01700	COG1595	DNA-templated transcription, initiation
HB370_RS01730	COG2814	Major facilitator Superfamily
HB370_RS01745	COG0656	L-ascorbic acid biosynthetic process
HB370_RS01775	COG3629	intracellular signal transduction
HB370_RS01785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS01790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB370_RS01800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HB370_RS01820	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HB370_RS01830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB370_RS01835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB370_RS01835	COG2022	thiamine diphosphate biosynthetic process
HB370_RS01845	COG2124	cytochrome p450
HB370_RS01850	COG3959	Transketolase, thiamine diphosphate binding domain
HB370_RS01870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB370_RS01885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB370_RS01930	COG3540	Alkaline phosphatase
HB370_RS01940	COG2223	nitrite transmembrane transporter activity
HB370_RS01945	COG2207	Transcriptional regulator
HB370_RS01960	COG0789	Transcriptional regulator
HB370_RS01965	COG0659	secondary active sulfate transmembrane transporter activity
HB370_RS01970	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HB370_RS02045	COG3629	intracellular signal transduction
HB370_RS02045	COG3903	Transcriptional regulator
HB370_RS02050	COG1476	TRANSCRIPTIONal
HB370_RS02070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB370_RS02085	COG1846	Transcriptional regulator
HB370_RS02090	COG0604	alcohol dehydrogenase
HB370_RS02095	COG0583	DNA-binding transcription factor activity
HB370_RS02105	COG2124	cytochrome p450
HB370_RS02160	COG2207	Transcriptional regulator
HB370_RS02185	COG2755	lipolytic protein G-D-S-L family
HB370_RS02285	COG1222	aaa ATPase
HB370_RS02320	COG0673	inositol 2-dehydrogenase activity
HB370_RS02325	COG2814	Major facilitator Superfamily
HB370_RS02340	COG3509	depolymerase
HB370_RS02350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HB370_RS02385	COG0411	ABC transporter
HB370_RS02390	COG0410	ABC transporter
HB370_RS02395	COG2508	Transcriptional regulator
HB370_RS02400	COG0583	DNA-binding transcription factor activity
HB370_RS02455	COG3979	chitinase
HB370_RS02470	COG2205	protein histidine kinase activity
HB370_RS02470	COG5002	protein histidine kinase activity
HB370_RS02470	COG0784	Response regulator, receiver
HB370_RS02485	COG2072	flavoprotein involved in K transport
HB370_RS02545	COG0009	L-threonylcarbamoyladenylate synthase
HB370_RS02560	COG0583	DNA-binding transcription factor activity
HB370_RS02575	COG1335	isochorismatase
HB370_RS02580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HB370_RS02605	COG1131	(ABC) transporter
HB370_RS02610	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS02615	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS02670	COG1960	acyl-CoA dehydrogenase activity
HB370_RS02700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS02705	COG4948	Mandelate Racemase Muconate Lactonizing
HB370_RS02740	COG0702	epimerase
HB370_RS02755	COG2264	protein methyltransferase activity
HB370_RS02770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS02785	COG2353	YceI-like domain
HB370_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS02835	COG2814	Major facilitator Superfamily
HB370_RS02935	COG1473	amidohydrolase
HB370_RS02960	COG0546	phosphoglycolate phosphatase activity
HB370_RS02965	COG1461	Dihydroxyacetone kinase
HB370_RS02970	COG2376	Dihydroxyacetone kinase
HB370_RS02975	COG0395	ABC-type sugar transport system, permease component
HB370_RS02980	COG1175	transmembrane transport
HB370_RS02985	COG2182	Extracellular solute-binding protein
HB370_RS02990	COG1501	Belongs to the glycosyl hydrolase 31 family
HB370_RS02995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB370_RS03035	COG1309	transcriptional regulator
HB370_RS03040	COG2814	Major facilitator Superfamily
HB370_RS03045	COG2910	NAD(P)H-binding
HB370_RS03050	COG1733	regulation of RNA biosynthetic process
HB370_RS03085	COG4977	sequence-specific DNA binding
HB370_RS03090	COG0583	DNA-binding transcription factor activity
HB370_RS03100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB370_RS03105	COG1960	acyl-CoA dehydrogenase activity
HB370_RS03140	COG2318	DinB family
HB370_RS03175	COG2197	response regulator
HB370_RS03185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB370_RS03190	COG0346	lactoylglutathione lyase activity
HB370_RS03235	COG0702	epimerase
HB370_RS03250	COG1522	sequence-specific DNA binding
HB370_RS03255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB370_RS03260	COG1228	amidohydrolase
HB370_RS03270	COG1846	Transcriptional regulator
HB370_RS03320	COG1472	Belongs to the glycosyl hydrolase 3 family
HB370_RS03325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB370_RS03330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB370_RS03360	COG0640	Transcriptional regulator
HB370_RS03390	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HB370_RS03395	COG0531	amino acid
HB370_RS03420	COG0300	oxidoreductase activity
HB370_RS03435	COG2233	PERMEase
HB370_RS03475	COG0778	Nitroreductase
HB370_RS03485	COG1309	transcriptional regulator
HB370_RS03530	COG1121	(ABC) transporter
HB370_RS03570	COG2318	DinB family
HB370_RS03650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB370_RS03665	COG4948	Mandelate Racemase Muconate Lactonizing
HB370_RS03680	COG4166	transmembrane transport
HB370_RS03695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB370_RS03715	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS03720	COG1309	transcriptional regulator
HB370_RS03765	COG4249	Peptidase C14 caspase catalytic subunit p20
HB370_RS03765	COG2319	Wd-40 repeat
HB370_RS03795	COG0477	Major facilitator Superfamily
HB370_RS03835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB370_RS03845	COG4948	Mandelate Racemase Muconate Lactonizing
HB370_RS03850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB370_RS03855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS03870	COG4565	transcriptional regulatory protein
HB370_RS03875	COG2205	protein histidine kinase activity
HB370_RS03880	COG0477	Major facilitator Superfamily
HB370_RS03910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB370_RS03930	COG0596	Alpha beta hydrolase
HB370_RS03945	COG2816	NAD+ diphosphatase activity
HB370_RS03955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS03970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB370_RS03975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB370_RS03990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HB370_RS03995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB370_RS04005	COG2319	Wd-40 repeat
HB370_RS04005	COG4249	Peptidase C14 caspase catalytic subunit p20
HB370_RS04035	COG2814	Major facilitator Superfamily
HB370_RS04055	COG1733	regulation of RNA biosynthetic process
HB370_RS04070	COG3629	intracellular signal transduction
HB370_RS04070	COG3903	Transcriptional regulator
HB370_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS04110	COG0251	oxidation-reduction process
HB370_RS04140	COG2814	Major facilitator Superfamily
HB370_RS04160	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS04180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB370_RS04185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB370_RS04195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HB370_RS04205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HB370_RS04215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB370_RS04230	COG1309	transcriptional regulator
HB370_RS04265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS04270	COG1819	glycosyl
HB370_RS04275	COG3973	AAA domain
HB370_RS04280	COG0456	acetyltransferase
HB370_RS04295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HB370_RS04300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB370_RS04305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB370_RS04315	COG0531	amino acid
HB370_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS04340	COG4865	methylaspartate mutase activity
HB370_RS04360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS04375	COG2267	carboxylic ester hydrolase activity
HB370_RS04400	COG2124	cytochrome p450
HB370_RS04420	COG2197	response regulator
HB370_RS04435	COG1136	(ABC) transporter
HB370_RS04435	COG0577	efflux transmembrane transporter activity
HB370_RS04475	COG0583	DNA-binding transcription factor activity
HB370_RS04535	COG2197	response regulator
HB370_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS04545	COG1295	ribonuclease BN
HB370_RS04560	COG0701	Predicted permease
HB370_RS04580	COG2353	YceI-like domain
HB370_RS04585	COG2353	YceI-like domain
HB370_RS04615	COG1285	pathogenesis
HB370_RS04630	COG0628	permease
HB370_RS04645	COG2770	Histidine kinase
HB370_RS04645	COG2208	phosphoserine phosphatase activity
HB370_RS04650	COG0596	Alpha beta hydrolase
HB370_RS04675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB370_RS04680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB370_RS04685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB370_RS04695	COG0438	transferase activity, transferring glycosyl groups
HB370_RS04725	COG0402	S-adenosylhomocysteine deaminase activity
HB370_RS04750	COG0586	Pfam SNARE associated Golgi protein
HB370_RS04815	COG3291	Pkd domain containing protein
HB370_RS04825	COG0583	DNA-binding transcription factor activity
HB370_RS04845	COG1733	regulation of RNA biosynthetic process
HB370_RS04895	COG0673	inositol 2-dehydrogenase activity
HB370_RS04915	COG0477	Major facilitator Superfamily
HB370_RS04925	COG0009	L-threonylcarbamoyladenylate synthase
HB370_RS04965	COG1793	dna ligase
HB370_RS04965	COG3285	dna ligase
HB370_RS05000	COG1414	Transcriptional regulator
HB370_RS05005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB370_RS05010	COG3285	dna ligase
HB370_RS05010	COG1793	dna ligase
HB370_RS05015	COG0181	hydroxymethylbilane synthase activity
HB370_RS05055	COG0366	Alpha amylase catalytic
HB370_RS05070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB370_RS05075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HB370_RS05095	COG1252	NADH dehydrogenase
HB370_RS05175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB370_RS05220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB370_RS05235	COG3647	Membrane
HB370_RS05245	COG0667	Aldo Keto reductase
HB370_RS05255	COG0583	DNA-binding transcription factor activity
HB370_RS05275	COG2304	oxidoreductase activity
HB370_RS05280	COG0328	RNA-DNA hybrid ribonuclease activity
HB370_RS05295	COG1396	sequence-specific DNA binding
HB370_RS05300	COG1191	sigma factor activity
HB370_RS05315	COG0667	Aldo Keto reductase
HB370_RS05320	COG0583	DNA-binding transcription factor activity
HB370_RS05330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB370_RS05335	COG0346	lactoylglutathione lyase activity
HB370_RS05370	COG2356	endonuclease I
HB370_RS05375	COG0667	Aldo Keto reductase
HB370_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS05395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS05400	COG0431	NADPH-dependent FMN reductase
HB370_RS05420	COG0531	amino acid
HB370_RS05425	COG3250	beta-galactosidase activity
HB370_RS05465	COG0367	asparagine synthase
HB370_RS05475	COG0673	inositol 2-dehydrogenase activity
HB370_RS05495	COG0510	thiamine kinase activity
HB370_RS05550	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS05560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB370_RS05635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB370_RS05635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HB370_RS05640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HB370_RS05645	COG0297	glycogen (starch) synthase activity
HB370_RS05650	COG0438	transferase activity, transferring glycosyl groups
HB370_RS05670	COG2192	nodulation
HB370_RS05675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB370_RS05695	COG2376	Dihydroxyacetone kinase
HB370_RS05700	COG1461	Dihydroxyacetone kinase
HB370_RS05705	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HB370_RS05730	COG1902	pentaerythritol trinitrate reductase activity
HB370_RS05730	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB370_RS05735	COG1942	4-Oxalocrotonate Tautomerase
HB370_RS05755	COG2890	protein-(glutamine-N5) methyltransferase activity
HB370_RS05775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB370_RS05790	COG3458	cephalosporin-C deacetylase activity
HB370_RS05800	COG2188	Transcriptional regulator
HB370_RS05825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HB370_RS05840	COG2066	Belongs to the glutaminase family
HB370_RS05855	COG1113	amino acid transport
HB370_RS05860	COG2186	Transcriptional regulator
HB370_RS05865	COG1968	undecaprenyl-diphosphatase activity
HB370_RS05870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HB370_RS05875	COG1993	acr, cog1993
HB370_RS05880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HB370_RS05905	COG1653	transport
HB370_RS05915	COG0395	ABC-type sugar transport system, permease component
HB370_RS05925	COG2197	response regulator
HB370_RS05930	COG4585	Histidine kinase
HB370_RS05935	COG1136	(ABC) transporter
HB370_RS05945	COG0346	lactoylglutathione lyase activity
HB370_RS06015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB370_RS06045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB370_RS06050	COG1024	Enoyl-CoA hydratase
HB370_RS06065	COG2084	Dehydrogenase
HB370_RS06095	COG1309	transcriptional regulator
HB370_RS06100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB370_RS06105	COG1482	cell wall glycoprotein biosynthetic process
HB370_RS06115	COG3507	Belongs to the glycosyl hydrolase 43 family
HB370_RS06135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB370_RS06145	COG0076	glutamate decarboxylase activity
HB370_RS06220	COG0514	ATP-dependent DNA helicase (RecQ)
HB370_RS06230	COG0367	asparagine synthase
HB370_RS06235	COG2308	Evidence 4 Homologs of previously reported genes of
HB370_RS06235	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HB370_RS06245	COG4221	oxidoreductase activity
HB370_RS06250	COG0477	Major facilitator Superfamily
HB370_RS06255	COG1959	2 iron, 2 sulfur cluster binding
HB370_RS06345	COG0783	Belongs to the Dps family
HB370_RS06370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS06400	COG0028	Belongs to the TPP enzyme family
HB370_RS06460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HB370_RS06485	COG0494	nUDIX hydrolase
HB370_RS06540	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS06570	COG1215	transferase activity, transferring glycosyl groups
HB370_RS06610	COG1349	DNA-binding transcription factor activity
HB370_RS06655	COG1619	proteins homologs of microcin C7 resistance protein MccF
HB370_RS06660	COG1940	carbohydrate kinase activity
HB370_RS06670	COG2813	Specifically methylates the guanine in position
HB370_RS06680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB370_RS06685	COG1349	DNA-binding transcription factor activity
HB370_RS06720	COG1846	Transcriptional regulator
HB370_RS06735	COG0445	tRNA wobble uridine modification
HB370_RS06740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB370_RS06745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB370_RS06750	COG1660	Displays ATPase and GTPase activities
HB370_RS06760	COG3345	alpha-galactosidase
HB370_RS06800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HB370_RS06820	COG0204	Acyl-transferase
HB370_RS06845	COG0584	glycerophosphoryl diester phosphodiesterase
HB370_RS06860	COG0667	Aldo Keto reductase
HB370_RS06880	COG0671	phosphoesterase, PA-phosphatase related
HB370_RS06890	COG1309	transcriptional regulator
HB370_RS06895	COG0493	'glutamate synthase
HB370_RS06900	COG2233	PERMEase
HB370_RS06905	COG0640	Transcriptional regulator
HB370_RS06910	COG1902	pentaerythritol trinitrate reductase activity
HB370_RS06915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB370_RS06925	COG3509	depolymerase
HB370_RS06935	COG3135	benzoate transporter
HB370_RS06945	COG1960	acyl-CoA dehydrogenase activity
HB370_RS06960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HB370_RS06975	COG2706	6-phosphogluconolactonase activity
HB370_RS06990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB370_RS06995	COG0477	Major facilitator Superfamily
HB370_RS07030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB370_RS07035	COG1116	anion transmembrane transporter activity
HB370_RS07045	COG2072	flavoprotein involved in K transport
HB370_RS07055	COG1132	(ABC) transporter
HB370_RS07085	COG1132	(ABC) transporter
HB370_RS07095	COG0254	rRNA binding
HB370_RS07110	COG1946	Acyl-CoA thioesterase
HB370_RS07120	COG2018	Roadblock/LC7 domain
HB370_RS07185	COG1113	amino acid transport
HB370_RS07200	COG1335	isochorismatase
HB370_RS07210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HB370_RS07230	COG1278	Cold shock
HB370_RS07260	COG0586	Pfam SNARE associated Golgi protein
HB370_RS07315	COG1960	acyl-CoA dehydrogenase activity
HB370_RS07320	COG1960	acyl-CoA dehydrogenase activity
HB370_RS07335	COG0492	ferredoxin-NADP+ reductase activity
HB370_RS07340	COG1793	dna ligase
HB370_RS07350	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS07360	COG3424	synthase
HB370_RS07365	COG2124	cytochrome p450
HB370_RS07375	COG1960	acyl-CoA dehydrogenase activity
HB370_RS07385	COG0242	peptide deformylase activity
HB370_RS07395	COG3442	glutamine amidotransferase
HB370_RS07400	COG0205	6-phosphofructokinase activity
HB370_RS07415	COG1522	sequence-specific DNA binding
HB370_RS07420	COG1834	amidinotransferase
HB370_RS07425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB370_RS07440	COG0204	Acyl-transferase
HB370_RS07455	COG0829	nickel cation binding
HB370_RS07460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HB370_RS07470	COG0804	urea catabolic process
HB370_RS07475	COG0832	Belongs to the urease beta subunit family
HB370_RS07480	COG0831	urea catabolic process
HB370_RS07490	COG0740	serine-type endopeptidase activity
HB370_RS07500	COG0791	NLP P60 protein
HB370_RS07500	COG1388	LysM domain
HB370_RS07525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HB370_RS07530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB370_RS07580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB370_RS07585	COG3663	DNA glycosylase
HB370_RS07610	COG4585	Histidine kinase
HB370_RS07615	COG2197	response regulator
HB370_RS07625	COG2188	Transcriptional regulator
HB370_RS07630	COG1595	DNA-templated transcription, initiation
HB370_RS07650	COG0626	cystathionine gamma-synthase activity
HB370_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS07695	COG1522	sequence-specific DNA binding
HB370_RS07715	COG0419	ATPase involved in DNA repair
HB370_RS07720	COG0420	3'-5' exonuclease activity
HB370_RS07725	COG1739	Uncharacterized protein family UPF0029
HB370_RS07740	COG1832	CoA-binding protein
HB370_RS07745	COG0640	Transcriptional regulator
HB370_RS07770	COG0110	maltose O-acetyltransferase activity
HB370_RS07840	COG1968	undecaprenyl-diphosphatase activity
HB370_RS07860	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HB370_RS07875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HB370_RS07880	COG0747	negative chemotaxis
HB370_RS07925	COG0477	Major facilitator Superfamily
HB370_RS07950	COG0697	spore germination
HB370_RS07995	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HB370_RS08050	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB370_RS08070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HB370_RS08070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HB370_RS08080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB370_RS08120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB370_RS08150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB370_RS08160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB370_RS08205	COG2018	Roadblock/LC7 domain
HB370_RS08220	COG1414	Transcriptional regulator
HB370_RS08245	COG2814	Major facilitator Superfamily
HB370_RS08250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HB370_RS08255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HB370_RS08260	COG1984	allophanate hydrolase subunit 2
HB370_RS08265	COG0438	transferase activity, transferring glycosyl groups
HB370_RS08270	COG0438	transferase activity, transferring glycosyl groups
HB370_RS08295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB370_RS08300	COG2364	Membrane
HB370_RS08315	COG3030	protein affecting phage T7 exclusion by the F plasmid
HB370_RS08320	COG0463	Glycosyl transferase, family 2
HB370_RS08345	COG1960	acyl-CoA dehydrogenase activity
HB370_RS08375	COG0237	dephospho-CoA kinase activity
HB370_RS08400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB370_RS08405	COG0140	phosphoribosyl-ATP diphosphatase activity
HB370_RS08410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HB370_RS08415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB370_RS08415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB370_RS08420	COG3201	nicotinamide mononucleotide transporter
HB370_RS08430	COG1846	Transcriptional regulator
HB370_RS08430	COG1940	carbohydrate kinase activity
HB370_RS08435	COG0738	Major facilitator superfamily
HB370_RS08440	COG2233	PERMEase
HB370_RS08455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB370_RS08465	COG0531	amino acid
HB370_RS08490	COG2390	Transcriptional regulator
HB370_RS08495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB370_RS08505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HB370_RS08520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HB370_RS08535	COG0194	GDP metabolic process
HB370_RS08545	COG0284	orotidine-5'-phosphate decarboxylase activity
HB370_RS08550	COG0167	dihydroorotate dehydrogenase activity
HB370_RS08555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB370_RS08560	COG0505	Belongs to the CarA family
HB370_RS08570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB370_RS08575	COG0540	Belongs to the ATCase OTCase family
HB370_RS08580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HB370_RS08590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HB370_RS08595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HB370_RS08600	COG0006	proline dipeptidase activity
HB370_RS08610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HB370_RS08615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB370_RS08620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HB370_RS08625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB370_RS08630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB370_RS08635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB370_RS08640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HB370_RS08660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HB370_RS08675	COG0124	histidyl-tRNA synthetase
HB370_RS08685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB370_RS08690	COG1196	nuclear chromosome segregation
HB370_RS08695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB370_RS08705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HB370_RS08710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB370_RS08715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB370_RS08725	COG2255	four-way junction helicase activity
HB370_RS08730	COG0632	four-way junction helicase activity
HB370_RS08735	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HB370_RS08740	COG0217	transcriptional regulatory protein
HB370_RS08745	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HB370_RS08750	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HB370_RS08760	COG0438	transferase activity, transferring glycosyl groups
HB370_RS08765	COG1560	Kdo2-lipid A biosynthetic process
HB370_RS08770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB370_RS08790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB370_RS08795	COG2176	DNA-directed DNA polymerase activity
HB370_RS08795	COG5002	protein histidine kinase activity
HB370_RS08820	COG0395	ABC-type sugar transport system, permease component
HB370_RS08825	COG1175	transmembrane transport
HB370_RS08835	COG0596	Alpha beta hydrolase
HB370_RS08885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB370_RS08940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB370_RS08940	COG1648	precorrin-2 dehydrogenase activity
HB370_RS08945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB370_RS08965	COG1464	Belongs to the NlpA lipoprotein family
HB370_RS08970	COG2011	ABC-type metal ion transport system permease component
HB370_RS08975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB370_RS09010	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS09010	COG0204	Acyl-transferase
HB370_RS09015	COG2132	Multicopper oxidase
HB370_RS09020	COG0477	Major facilitator Superfamily
HB370_RS09035	COG0165	Argininosuccinate lyase
HB370_RS09040	COG0137	argininosuccinate synthase activity
HB370_RS09070	COG1438	arginine binding
HB370_RS09075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB370_RS09080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HB370_RS09085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB370_RS09090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HB370_RS09100	COG0463	Glycosyl transferase, family 2
HB370_RS09140	COG0697	spore germination
HB370_RS09150	COG1649	PFAM Uncharacterised BCR, COG1649
HB370_RS09180	COG0072	phenylalanine-tRNA ligase activity
HB370_RS09180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB370_RS09185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HB370_RS09190	COG5002	protein histidine kinase activity
HB370_RS09195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB370_RS09200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HB370_RS09205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HB370_RS09210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HB370_RS09250	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS09255	COG0174	glutamine synthetase
HB370_RS09260	COG2186	Transcriptional regulator
HB370_RS09265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HB370_RS09285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HB370_RS09295	COG4176	ABC-type proline glycine betaine transport system permease component
HB370_RS09300	COG4175	Glycine betaine
HB370_RS09300	COG0517	IMP dehydrogenase activity
HB370_RS09305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB370_RS09320	COG0564	pseudouridine synthase activity
HB370_RS09355	COG0805	protein transport
HB370_RS09360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB370_RS09395	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HB370_RS09405	COG1609	Transcriptional regulator
HB370_RS09410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HB370_RS09415	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HB370_RS09430	COG4122	O-methyltransferase activity
HB370_RS09435	COG1222	aaa ATPase
HB370_RS09460	COG1994	Peptidase M50
HB370_RS09460	COG0517	IMP dehydrogenase activity
HB370_RS09470	COG2197	response regulator
HB370_RS09475	COG0747	negative chemotaxis
HB370_RS09480	COG0747	negative chemotaxis
HB370_RS09485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB370_RS09490	COG1410	methionine synthase
HB370_RS09490	COG0646	methionine synthase
HB370_RS09495	COG1414	Transcriptional regulator
HB370_RS09500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB370_RS09505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB370_RS09510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HB370_RS09520	COG0215	cysteine-tRNA ligase activity
HB370_RS09535	COG0406	alpha-ribazole phosphatase activity
HB370_RS09540	COG0598	Magnesium transport protein CorA
HB370_RS09550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS09555	COG0667	Aldo Keto reductase
HB370_RS09585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB370_RS09595	COG1796	DNA polymerase
HB370_RS09595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HB370_RS09615	COG3012	SEC-C Motif Domain Protein
HB370_RS09620	COG2186	Transcriptional regulator
HB370_RS09625	COG3265	gluconokinase activity
HB370_RS09645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HB370_RS09650	COG2149	membrane
HB370_RS09690	COG0019	diaminopimelate decarboxylase activity
HB370_RS09705	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS09715	COG3876	Protein conserved in bacteria
HB370_RS09755	COG1960	acyl-CoA dehydrogenase activity
HB370_RS09765	COG0640	Transcriptional regulator
HB370_RS09795	COG2851	Citrate transporter
HB370_RS09800	COG1309	transcriptional regulator
HB370_RS09810	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HB370_RS09815	COG2188	Transcriptional regulator
HB370_RS09840	COG2755	lipolytic protein G-D-S-L family
HB370_RS09860	COG1725	Transcriptional regulator
HB370_RS09870	COG2226	methyltransferase
HB370_RS09900	COG0587	DNA-directed DNA polymerase activity
HB370_RS09935	COG0765	amino acid transport
HB370_RS09945	COG1799	cell septum assembly
HB370_RS09950	COG1960	acyl-CoA dehydrogenase activity
HB370_RS09955	COG0477	Major facilitator Superfamily
HB370_RS09970	COG0671	phosphoesterase, PA-phosphatase related
HB370_RS09980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB370_RS10000	COG1160	GTP binding
HB370_RS10010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HB370_RS10035	COG3541	Predicted nucleotidyltransferase
HB370_RS10040	COG1397	ADP-ribosylglycohydrolase
HB370_RS10045	COG1187	pseudouridine synthase activity
HB370_RS10050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB370_RS10055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB370_RS10070	COG0686	Belongs to the AlaDH PNT family
HB370_RS10080	COG0494	nUDIX hydrolase
HB370_RS10085	COG0504	CTP synthase activity
HB370_RS10090	COG3387	PFAM Glycoside hydrolase 15-related
HB370_RS10095	COG0277	FAD linked oxidase domain protein
HB370_RS10100	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HB370_RS10120	COG0297	glycogen (starch) synthase activity
HB370_RS10130	COG0497	DNA recombination
HB370_RS10135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB370_RS10155	COG1120	ATPase activity
HB370_RS10160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB370_RS10165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB370_RS10170	COG0647	UMP catabolic process
HB370_RS10200	COG2094	Belongs to the DNA glycosylase MPG family
HB370_RS10210	COG1881	PFAM PEBP family protein
HB370_RS10230	COG1119	ATPase activity
HB370_RS10245	COG2197	response regulator
HB370_RS10250	COG3850	Histidine kinase
HB370_RS10260	COG1716	ATPase activity
HB370_RS10260	COG1131	(ABC) transporter
HB370_RS10260	COG0842	Transport permease protein
HB370_RS10265	COG3830	Belongs to the UPF0237 family
HB370_RS10265	COG0560	Phosphoserine phosphatase
HB370_RS10285	COG2186	Transcriptional regulator
HB370_RS10330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB370_RS10350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB370_RS10355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB370_RS10365	COG1404	Belongs to the peptidase S8 family
HB370_RS10375	COG1063	alcohol dehydrogenase
HB370_RS10395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HB370_RS10410	COG3387	PFAM Glycoside hydrolase 15-related
HB370_RS10430	COG0488	(ABC) transporter
HB370_RS10450	COG0235	Class ii aldolase
HB370_RS10470	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HB370_RS10475	COG1492	cobalamin metabolic process
HB370_RS10495	COG1797	cobyrinic acid a,c-diamide synthase activity
HB370_RS10530	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HB370_RS10555	COG0765	amino acid transport
HB370_RS10560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB370_RS10565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB370_RS10570	COG0456	acetyltransferase
HB370_RS10575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB370_RS10580	COG1917	Cupin 2, conserved barrel domain protein
HB370_RS10585	COG5285	phytanoyl-CoA dioxygenase
HB370_RS10590	COG1902	pentaerythritol trinitrate reductase activity
HB370_RS10595	COG1846	Transcriptional regulator
HB370_RS10600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB370_RS10630	COG1414	Transcriptional regulator
HB370_RS10645	COG1595	DNA-templated transcription, initiation
HB370_RS10660	COG4677	pectinesterase activity
HB370_RS10670	COG2755	lipolytic protein G-D-S-L family
HB370_RS10685	COG3507	Belongs to the glycosyl hydrolase 43 family
HB370_RS10700	COG0395	ABC-type sugar transport system, permease component
HB370_RS10705	COG1175	transmembrane transport
HB370_RS10715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS10720	COG1802	Transcriptional regulator
HB370_RS10735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS10740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB370_RS10745	COG1349	DNA-binding transcription factor activity
HB370_RS10760	COG0395	ABC-type sugar transport system, permease component
HB370_RS10765	COG1063	alcohol dehydrogenase
HB370_RS10775	COG1309	transcriptional regulator
HB370_RS10815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS10820	COG2171	N-acyltransferase activity
HB370_RS10825	COG3226	Transcriptional regulator
HB370_RS10830	COG2076	Multidrug Resistance protein
HB370_RS10835	COG2151	metal-sulfur cluster biosynthetic enzyme
HB370_RS10840	COG0822	iron-sulfur transferase activity
HB370_RS10845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB370_RS10850	COG0396	ATPase activity
HB370_RS10860	COG0719	Fe-S assembly protein
HB370_RS10875	COG2746	aminoglycoside 3-N-acetyltransferase activity
HB370_RS10880	COG1131	(ABC) transporter
HB370_RS10890	COG1612	heme a metabolic process
HB370_RS10905	COG0109	protoheme IX farnesyltransferase activity
HB370_RS10915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB370_RS10930	COG0363	glucosamine-6-phosphate deaminase activity
HB370_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS10940	COG2207	Transcriptional regulator
HB370_RS10960	COG1309	transcriptional regulator
HB370_RS10970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS10980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS10980	COG3321	synthase
HB370_RS10980	COG0300	oxidoreductase activity
HB370_RS10980	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS11005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS11010	COG0166	Belongs to the GPI family
HB370_RS11025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HB370_RS11030	COG0149	triose-phosphate isomerase activity
HB370_RS11035	COG0126	phosphoglycerate kinase activity
HB370_RS11040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB370_RS11050	COG1481	regulation of sporulation
HB370_RS11055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HB370_RS11060	COG1660	Displays ATPase and GTPase activities
HB370_RS11065	COG0322	excinuclease ABC activity
HB370_RS11085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB370_RS11095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB370_RS11105	COG0765	amino acid transport
HB370_RS11115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HB370_RS11120	COG0477	Major facilitator Superfamily
HB370_RS11125	COG0387	Pfam Sodium calcium exchanger
HB370_RS11140	COG0556	nucleotide-excision repair
HB370_RS11150	COG0584	glycerophosphoryl diester phosphodiesterase
HB370_RS11155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB370_RS11165	COG2313	pseudouridylate synthase activity
HB370_RS11170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HB370_RS11170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB370_RS11180	COG0598	Magnesium transport protein CorA
HB370_RS11195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB370_RS11200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB370_RS11240	COG0402	S-adenosylhomocysteine deaminase activity
HB370_RS11260	COG1953	Uracil, thiamine, allantoin
HB370_RS11265	COG1802	Transcriptional regulator
HB370_RS11280	COG2226	methyltransferase
HB370_RS11295	COG0237	dephospho-CoA kinase activity
HB370_RS11305	COG0539	negative regulation of cytoplasmic translation
HB370_RS11310	COG2226	methyltransferase
HB370_RS11315	COG1643	Atp-dependent helicase
HB370_RS11355	COG2050	protein possibly involved in aromatic compounds catabolism
HB370_RS11405	COG0737	Belongs to the 5'-nucleotidase family
HB370_RS11420	COG0702	epimerase
HB370_RS11430	COG1605	Chorismate mutase
HB370_RS11430	COG0287	Prephenate dehydrogenase
HB370_RS11460	COG1309	transcriptional regulator
HB370_RS11480	COG0667	Aldo Keto reductase
HB370_RS11490	COG0070	glutamate synthase
HB370_RS11490	COG0067	glutamate synthase
HB370_RS11490	COG0069	glutamate synthase activity
HB370_RS11510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS11525	COG0159	tryptophan synthase activity
HB370_RS11530	COG0133	tryptophan synthase activity
HB370_RS11535	COG0134	indole-3-glycerol-phosphate synthase activity
HB370_RS11555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB370_RS11560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB370_RS11580	COG0107	imidazoleglycerol-phosphate synthase activity
HB370_RS11585	COG0251	oxidation-reduction process
HB370_RS11590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HB370_RS11595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB370_RS11605	COG0131	Imidazoleglycerol-phosphate dehydratase
HB370_RS11610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB370_RS11615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB370_RS11635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB370_RS11655	COG1432	Conserved Protein
HB370_RS11665	COG0587	DNA-directed DNA polymerase activity
HB370_RS11705	COG2153	protein acetylation
HB370_RS11715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HB370_RS11725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB370_RS11730	COG3599	regulation of cell shape
HB370_RS11740	COG1799	cell septum assembly
HB370_RS11755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB370_RS11765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HB370_RS11775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HB370_RS11780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB370_RS11790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB370_RS11795	COG0768	penicillin binding
HB370_RS11805	COG0275	rRNA processing
HB370_RS11815	COG0714	Associated with various cellular activities
HB370_RS11835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB370_RS11845	COG1309	transcriptional regulator
HB370_RS11870	COG0352	thiamine-phosphate diphosphorylase activity
HB370_RS11890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB370_RS11890	COG2022	thiamine diphosphate biosynthetic process
HB370_RS11900	COG2022	thiamine diphosphate biosynthetic process
HB370_RS11905	COG2815	serine threonine protein kinase
HB370_RS11905	COG0515	serine threonine protein kinase
HB370_RS11910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HB370_RS11920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB370_RS11925	COG2193	ferroxidase activity
HB370_RS11935	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HB370_RS11955	COG0205	6-phosphofructokinase activity
HB370_RS11965	COG4585	Histidine kinase
HB370_RS11990	COG1940	carbohydrate kinase activity
HB370_RS12000	COG0003	Pfam Anion-transporting ATPase
HB370_RS12020	COG0438	transferase activity, transferring glycosyl groups
HB370_RS12035	COG0791	NLP P60 protein
HB370_RS12035	COG3883	PFAM NLP P60 protein
HB370_RS12065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB370_RS12070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB370_RS12075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HB370_RS12080	COG0723	plastoquinol--plastocyanin reductase activity
HB370_RS12085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB370_RS12095	COG0028	Belongs to the TPP enzyme family
HB370_RS12115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB370_RS12120	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HB370_RS12125	COG2124	cytochrome p450
HB370_RS12130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HB370_RS12135	COG0723	plastoquinol--plastocyanin reductase activity
HB370_RS12140	COG2010	Cytochrome c
HB370_RS12145	COG1845	cytochrome c oxidase, subunit III
HB370_RS12155	COG1376	ErfK ybiS ycfS ynhG family protein
HB370_RS12165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB370_RS12170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB370_RS12180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS12200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB370_RS12205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB370_RS12210	COG2197	response regulator
HB370_RS12215	COG4585	Histidine kinase
HB370_RS12240	COG2226	methyltransferase
HB370_RS12245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB370_RS12265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB370_RS12270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HB370_RS12270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HB370_RS12290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HB370_RS12295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB370_RS12300	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB370_RS12310	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HB370_RS12330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB370_RS12355	COG0321	lipoyl(octanoyl) transferase activity
HB370_RS12360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB370_RS12395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB370_RS12400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS12415	COG2329	Antibiotic biosynthesis monooxygenase
HB370_RS12430	COG0174	glutamine synthetase
HB370_RS12440	COG0501	Belongs to the peptidase M48B family
HB370_RS12475	COG0745	RESPONSE REGULATOR receiver
HB370_RS12490	COG2197	response regulator
HB370_RS12525	COG1309	transcriptional regulator
HB370_RS12545	COG0366	Alpha amylase catalytic
HB370_RS12550	COG3833	ABC-type maltose transport systems, permease component
HB370_RS12555	COG1175	transmembrane transport
HB370_RS12565	COG1609	Transcriptional regulator
HB370_RS12575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB370_RS12585	COG3511	phospholipase C
HB370_RS12600	COG1982	Orn Lys Arg decarboxylase major
HB370_RS12605	COG0174	glutamine synthetase
HB370_RS12630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB370_RS12635	COG0037	tRNA processing
HB370_RS12635	COG0590	tRNA wobble adenosine to inosine editing
HB370_RS12645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS12655	COG0662	Cupin 2, conserved barrel domain protein
HB370_RS12660	COG1960	acyl-CoA dehydrogenase activity
HB370_RS12690	COG1959	2 iron, 2 sulfur cluster binding
HB370_RS12710	COG2755	lipolytic protein G-D-S-L family
HB370_RS12760	COG1309	transcriptional regulator
HB370_RS12765	COG2814	Major facilitator Superfamily
HB370_RS12780	COG0477	Major facilitator Superfamily
HB370_RS12785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HB370_RS12825	COG1994	Peptidase M50
HB370_RS12875	COG2837	iron assimilation
HB370_RS12880	COG0672	)-iron permease
HB370_RS12905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB370_RS12910	COG2814	Major facilitator Superfamily
HB370_RS12930	COG0667	Aldo Keto reductase
HB370_RS12935	COG2259	Doxx family
HB370_RS12955	COG2197	response regulator
HB370_RS12980	COG2815	serine threonine protein kinase
HB370_RS12980	COG0515	serine threonine protein kinase
HB370_RS13005	COG0515	serine threonine protein kinase
HB370_RS13005	COG2815	serine threonine protein kinase
HB370_RS13010	COG2815	serine threonine protein kinase
HB370_RS13010	COG0515	serine threonine protein kinase
HB370_RS13050	COG0210	DNA helicase
HB370_RS13110	COG3022	response to hydroperoxide
HB370_RS13115	COG0800	Aldolase
HB370_RS13130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB370_RS13155	COG2030	dehydratase
HB370_RS13170	COG2197	response regulator
HB370_RS13190	COG0477	Major facilitator Superfamily
HB370_RS13200	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB370_RS13235	COG0438	transferase activity, transferring glycosyl groups
HB370_RS13240	COG1309	transcriptional regulator
HB370_RS13300	COG3845	ABC transporter
HB370_RS13315	COG3619	membrane
HB370_RS13365	COG0477	Major facilitator Superfamily
HB370_RS13370	COG4122	O-methyltransferase activity
HB370_RS13475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB370_RS13490	COG1358	cellular component organization or biogenesis
HB370_RS13535	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HB370_RS13540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB370_RS13550	COG0477	Major facilitator Superfamily
HB370_RS13555	COG1309	transcriptional regulator
HB370_RS13570	COG0667	Aldo Keto reductase
HB370_RS13575	COG0789	Transcriptional regulator
HB370_RS13605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB370_RS13610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB370_RS13615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS13640	COG1280	lysine exporter protein (LysE YggA)
HB370_RS13655	COG2130	NADP-dependent
HB370_RS13660	COG1764	response to oxidative stress
HB370_RS13695	COG4214	carbohydrate transport
HB370_RS13725	COG2197	response regulator
HB370_RS13730	COG3507	Belongs to the glycosyl hydrolase 43 family
HB370_RS13765	COG0395	ABC-type sugar transport system, permease component
HB370_RS13770	COG1175	transmembrane transport
HB370_RS13790	COG3386	PFAM SMP-30 Gluconolaconase
HB370_RS13795	COG1414	Transcriptional regulator
HB370_RS13815	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS13820	COG0825	malonyl-CoA metabolic process
HB370_RS13820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HB370_RS13860	COG1077	Cell shape determining protein MreB Mrl
HB370_RS13880	COG0477	Major facilitator Superfamily
HB370_RS13885	COG1473	amidohydrolase
HB370_RS13890	COG0531	amino acid
HB370_RS13950	COG1070	Carbohydrate kinase
HB370_RS13965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB370_RS13970	COG0358	DNA primase activity
HB370_RS13980	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HB370_RS13990	COG2949	membrane
HB370_RS13995	COG0243	molybdopterin cofactor binding
HB370_RS14025	COG1733	regulation of RNA biosynthetic process
HB370_RS14035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB370_RS14040	COG2146	nitrite reductase [NAD(P)H] activity
HB370_RS14040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB370_RS14050	COG1309	transcriptional regulator
HB370_RS14055	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS14060	COG0395	ABC-type sugar transport system, permease component
HB370_RS14065	COG1175	transmembrane transport
HB370_RS14070	COG2182	Extracellular solute-binding protein
HB370_RS14085	COG0574	Belongs to the PEP-utilizing enzyme family
HB370_RS14085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB370_RS14090	COG1940	carbohydrate kinase activity
HB370_RS14090	COG1846	Transcriptional regulator
HB370_RS14120	COG0477	Major facilitator Superfamily
HB370_RS14155	COG0667	Aldo Keto reductase
HB370_RS14165	COG0423	glycine-tRNA ligase activity
HB370_RS14170	COG3443	Belongs to the bacterial solute-binding protein 9 family
HB370_RS14170	COG0803	Belongs to the bacterial solute-binding protein 9 family
HB370_RS14175	COG1121	(ABC) transporter
HB370_RS14180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB370_RS14190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB370_RS14195	COG1381	Involved in DNA repair and RecF pathway recombination
HB370_RS14210	COG0747	negative chemotaxis
HB370_RS14220	COG0444	Belongs to the ABC transporter superfamily
HB370_RS14225	COG4608	Belongs to the ABC transporter superfamily
HB370_RS14230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS14235	COG1595	DNA-templated transcription, initiation
HB370_RS14250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB370_RS14275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB370_RS14295	COG2315	Protein conserved in bacteria
HB370_RS14305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HB370_RS14320	COG4948	Mandelate Racemase Muconate Lactonizing
HB370_RS14325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB370_RS14330	COG1234	tRNA 3'-trailer cleavage
HB370_RS14335	COG0537	adenosine 5'-monophosphoramidase activity
HB370_RS14340	COG0793	Belongs to the peptidase S41A family
HB370_RS14340	COG4946	Tricorn protease homolog
HB370_RS14355	COG2070	2-Nitropropane dioxygenase
HB370_RS14360	COG0484	heat shock protein binding
HB370_RS14365	COG1420	regulation of RNA biosynthetic process
HB370_RS14400	COG0481	GTPase activity
HB370_RS14410	COG0268	Binds directly to 16S ribosomal RNA
HB370_RS14425	COG2353	YceI-like domain
HB370_RS14435	COG1555	photosystem II stabilization
HB370_RS14440	COG1307	EDD domain protein, DegV family
HB370_RS14450	COG0495	leucyl-tRNA aminoacylation
HB370_RS14460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB370_RS14490	COG0588	phosphoglycerate mutase activity
HB370_RS14495	COG0799	negative regulation of ribosome biogenesis
HB370_RS14505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HB370_RS14520	COG0501	Belongs to the peptidase M48B family
HB370_RS14535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HB370_RS14545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HB370_RS14555	COG0438	transferase activity, transferring glycosyl groups
HB370_RS14560	COG0463	Glycosyl transferase, family 2
HB370_RS14560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB370_RS14565	COG0463	Glycosyl transferase, family 2
HB370_RS14565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB370_RS14575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HB370_RS14580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HB370_RS14585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HB370_RS14590	COG0371	Dehydrogenase
HB370_RS14600	COG1530	ribonuclease E activity
HB370_RS14630	COG0772	Belongs to the SEDS family
HB370_RS14635	COG0768	penicillin binding
HB370_RS14650	COG1077	Cell shape determining protein MreB Mrl
HB370_RS14655	COG0105	UTP biosynthetic process
HB370_RS14665	COG0285	dihydrofolate synthase activity
HB370_RS14670	COG0525	valine-tRNA ligase activity
HB370_RS14680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HB370_RS14685	COG0740	serine-type endopeptidase activity
HB370_RS14690	COG0740	serine-type endopeptidase activity
HB370_RS14695	COG0544	peptidyl-prolyl cis-trans isomerase activity
HB370_RS14715	COG3594	Acyltransferase
HB370_RS14735	COG4552	Acetyltransferase involved in intracellular survival and related
HB370_RS14750	COG1113	amino acid transport
HB370_RS14760	COG1113	amino acid transport
HB370_RS14765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB370_RS14770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB370_RS14785	COG2755	lipolytic protein G-D-S-L family
HB370_RS14810	COG2814	Major facilitator Superfamily
HB370_RS14815	COG0583	DNA-binding transcription factor activity
HB370_RS14860	COG0668	transmembrane transport
HB370_RS14875	COG1175	transmembrane transport
HB370_RS14880	COG0395	ABC-type sugar transport system, permease component
HB370_RS14885	COG1486	melibiose metabolic process
HB370_RS14900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB370_RS14975	COG2188	Transcriptional regulator
HB370_RS15070	COG0629	single-stranded DNA binding
HB370_RS15105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB370_RS15115	COG2304	oxidoreductase activity
HB370_RS15150	COG0438	transferase activity, transferring glycosyl groups
HB370_RS15175	COG0438	transferase activity, transferring glycosyl groups
HB370_RS15195	COG0492	ferredoxin-NADP+ reductase activity
HB370_RS15225	COG1131	(ABC) transporter
HB370_RS15240	COG3962	Belongs to the TPP enzyme family
HB370_RS15245	COG3718	enzyme involved in inositol metabolism
HB370_RS15255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS15285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB370_RS15330	COG1129	ABC transporter
HB370_RS15340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS15345	COG1869	D-ribose catabolic process
HB370_RS15350	COG0583	DNA-binding transcription factor activity
HB370_RS15390	COG1959	2 iron, 2 sulfur cluster binding
HB370_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS15405	COG0640	Transcriptional regulator
HB370_RS15410	COG0798	PFAM Bile acid sodium symporter
HB370_RS15415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB370_RS15440	COG0673	inositol 2-dehydrogenase activity
HB370_RS15445	COG1609	Transcriptional regulator
HB370_RS15470	COG1472	Belongs to the glycosyl hydrolase 3 family
HB370_RS15505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB370_RS15515	COG2814	Major facilitator Superfamily
HB370_RS15520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS15545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HB370_RS15570	COG0028	Belongs to the TPP enzyme family
HB370_RS15580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB370_RS15600	COG1946	Acyl-CoA thioesterase
HB370_RS15610	COG1309	transcriptional regulator
HB370_RS15615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB370_RS15630	COG1960	acyl-CoA dehydrogenase activity
HB370_RS15650	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HB370_RS15685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB370_RS15695	COG0589	response to stress
HB370_RS15710	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB370_RS15730	COG0395	ABC-type sugar transport system, permease component
HB370_RS15760	COG3903	Transcriptional regulator
HB370_RS15760	COG3629	intracellular signal transduction
HB370_RS15765	COG3469	chitinase activity
HB370_RS15770	COG5002	protein histidine kinase activity
HB370_RS15785	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HB370_RS15800	COG0406	alpha-ribazole phosphatase activity
HB370_RS15825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS15860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB370_RS15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB370_RS15870	COG0765	amino acid transport
HB370_RS15875	COG0765	amino acid transport
HB370_RS15880	COG1126	abc transporter atp-binding protein
HB370_RS15895	COG3397	chitin binding
HB370_RS15915	COG2186	Transcriptional regulator
HB370_RS15965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB370_RS15970	COG2188	Transcriptional regulator
HB370_RS15980	COG1940	carbohydrate kinase activity
HB370_RS15985	COG0673	inositol 2-dehydrogenase activity
HB370_RS15990	COG4702	Belongs to the UPF0303 family
HB370_RS16005	COG0706	membrane insertase activity
HB370_RS16045	COG0701	Predicted permease
HB370_RS16060	COG0556	nucleotide-excision repair
HB370_RS16070	COG0071	Belongs to the small heat shock protein (HSP20) family
HB370_RS16090	COG2271	Major facilitator Superfamily
HB370_RS16095	COG2733	membrane
HB370_RS16100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HB370_RS16130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB370_RS16145	COG4555	ABC transporter
HB370_RS16155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HB370_RS16160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB370_RS16165	COG1263	PTS System
HB370_RS16170	COG1263	PTS System
HB370_RS16205	COG1113	amino acid transport
HB370_RS16215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB370_RS16225	COG1335	isochorismatase
HB370_RS16245	COG1714	RDD family
HB370_RS16265	COG0277	FAD linked oxidase domain protein
HB370_RS16275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HB370_RS16335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB370_RS16350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HB370_RS16360	COG1678	Uncharacterized ACR, COG1678
HB370_RS16365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB370_RS16370	COG0776	regulation of translation
HB370_RS16380	COG3973	AAA domain
HB370_RS16405	COG2223	nitrite transmembrane transporter activity
HB370_RS16415	COG0583	DNA-binding transcription factor activity
HB370_RS16430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HB370_RS16435	COG0793	Belongs to the peptidase S41A family
HB370_RS16440	COG2177	Part of the ABC transporter FtsEX involved in
HB370_RS16445	COG2884	Cell division ATP-binding protein ftsE
HB370_RS16460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HB370_RS16465	COG0515	serine threonine protein kinase
HB370_RS16470	COG0515	serine threonine protein kinase
HB370_RS16475	COG1674	ftsk spoiiie
HB370_RS16490	COG0395	ABC-type sugar transport system, permease component
HB370_RS16495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB370_RS16500	COG0463	Glycosyl transferase, family 2
HB370_RS16500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB370_RS16505	COG1764	response to oxidative stress
HB370_RS16510	COG1846	Transcriptional regulator
HB370_RS16545	COG1134	teichoic acid transport
HB370_RS16550	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HB370_RS16555	COG1215	transferase activity, transferring glycosyl groups
HB370_RS16565	COG2902	Dehydrogenase
HB370_RS16590	COG0653	protein targeting
HB370_RS16600	COG3214	Protein conserved in bacteria
HB370_RS16605	COG2197	response regulator
HB370_RS16610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HB370_RS16620	COG0823	Involved in the tonB-independent uptake of proteins
HB370_RS16625	COG5000	phosphorelay sensor kinase activity
HB370_RS16625	COG5002	protein histidine kinase activity
HB370_RS16630	COG0745	RESPONSE REGULATOR receiver
HB370_RS16645	COG0546	phosphoglycolate phosphatase activity
HB370_RS16715	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HB370_RS16735	COG0714	Associated with various cellular activities
HB370_RS16775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB370_RS16795	COG1482	cell wall glycoprotein biosynthetic process
HB370_RS16805	COG2835	tetraacyldisaccharide 4'-kinase activity
HB370_RS16845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HB370_RS16850	COG0778	Nitroreductase
HB370_RS16850	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HB370_RS16875	COG1316	TRANSCRIPTIONal
HB370_RS16885	COG1316	TRANSCRIPTIONal
HB370_RS16895	COG1316	TRANSCRIPTIONal
HB370_RS16905	COG1316	TRANSCRIPTIONal
HB370_RS16920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB370_RS16965	COG2205	protein histidine kinase activity
HB370_RS16970	COG0745	RESPONSE REGULATOR receiver
HB370_RS16975	COG3104	oligopeptide transport
HB370_RS16990	COG1366	Belongs to the anti-sigma-factor antagonist family
HB370_RS16995	COG1191	sigma factor activity
HB370_RS17000	COG1228	amidohydrolase
HB370_RS17010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB370_RS17015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HB370_RS17065	COG4221	oxidoreductase activity
HB370_RS17080	COG2755	lipolytic protein G-D-S-L family
HB370_RS17085	COG0183	Belongs to the thiolase family
HB370_RS17120	COG0577	efflux transmembrane transporter activity
HB370_RS17120	COG1136	(ABC) transporter
HB370_RS17125	COG1136	(ABC) transporter
HB370_RS17125	COG0577	efflux transmembrane transporter activity
HB370_RS17130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB370_RS17135	COG1252	NADH dehydrogenase
HB370_RS17155	COG0148	phosphopyruvate hydratase activity
HB370_RS17170	COG2124	cytochrome p450
HB370_RS17250	COG1136	(ABC) transporter
HB370_RS17255	COG0477	Major facilitator Superfamily
HB370_RS17285	COG4585	Histidine kinase
HB370_RS17300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HB370_RS17305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB370_RS17310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HB370_RS17315	COG0193	aminoacyl-tRNA hydrolase activity
HB370_RS17325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HB370_RS17335	COG1309	transcriptional regulator
HB370_RS17345	COG4106	trans-aconitate 2-methyltransferase activity
HB370_RS17355	COG2197	response regulator
HB370_RS17365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HB370_RS17405	COG0488	(ABC) transporter
HB370_RS17415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HB370_RS17420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB370_RS17430	COG0084	hydrolase, TatD family'
HB370_RS17465	COG0310	cobalt ion transport
HB370_RS17475	COG1122	ATPase activity
HB370_RS17490	COG0442	prolyl-tRNA aminoacylation
HB370_RS17510	COG2409	Drug exporters of the RND superfamily
HB370_RS17520	COG0793	Belongs to the peptidase S41A family
HB370_RS17520	COG4946	Tricorn protease homolog
HB370_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS17535	COG2267	carboxylic ester hydrolase activity
HB370_RS17540	COG2072	flavoprotein involved in K transport
HB370_RS17550	COG0708	Exodeoxyribonuclease III
HB370_RS17555	COG0454	-acetyltransferase
HB370_RS17570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB370_RS17575	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB370_RS17575	COG0315	cyclic pyranopterin monophosphate synthase activity
HB370_RS17580	COG0315	cyclic pyranopterin monophosphate synthase activity
HB370_RS17590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB370_RS17595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB370_RS17610	COG0477	Major facilitator Superfamily
HB370_RS17620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HB370_RS17630	COG1970	mechanosensitive ion channel activity
HB370_RS17645	COG3191	aminopeptidase activity
HB370_RS17650	COG1376	ErfK ybiS ycfS ynhG family protein
HB370_RS17665	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB370_RS17665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB370_RS17665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB370_RS17675	COG1349	DNA-binding transcription factor activity
HB370_RS17680	COG0477	Major facilitator Superfamily
HB370_RS17700	COG1247	-acetyltransferase
HB370_RS17705	COG3384	dioxygenase
HB370_RS17710	COG1846	Transcriptional regulator
HB370_RS17730	COG1414	Transcriptional regulator
HB370_RS17790	COG0386	Belongs to the glutathione peroxidase family
HB370_RS17810	COG1686	Belongs to the peptidase S11 family
HB370_RS17840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HB370_RS17880	COG3903	Transcriptional regulator
HB370_RS17880	COG3629	intracellular signal transduction
HB370_RS17900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB370_RS17900	COG0515	serine threonine protein kinase
HB370_RS17920	COG1522	sequence-specific DNA binding
HB370_RS17925	COG1280	lysine exporter protein (LysE YggA)
HB370_RS17940	COG0259	pyridoxamine-phosphate oxidase activity
HB370_RS17955	COG2072	flavoprotein involved in K transport
HB370_RS17965	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HB370_RS17970	COG2814	Major facilitator Superfamily
HB370_RS18060	COG4821	SIS domain
HB370_RS18070	COG0259	pyridoxamine-phosphate oxidase activity
HB370_RS18085	COG1309	transcriptional regulator
HB370_RS18095	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS18110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB370_RS18125	COG0281	malic enzyme
HB370_RS18130	COG5006	permease, DMT superfamily
HB370_RS18135	COG0247	lactate metabolic process
HB370_RS18135	COG0277	FAD linked oxidase domain protein
HB370_RS18140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HB370_RS18180	COG1846	Transcriptional regulator
HB370_RS18185	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS18195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HB370_RS18225	COG0667	Aldo Keto reductase
HB370_RS18250	COG2252	PERMEase
HB370_RS18260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB370_RS18295	COG2814	Major facilitator Superfamily
HB370_RS18305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB370_RS18310	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HB370_RS18315	COG1278	Cold shock
HB370_RS18345	COG1061	Type III restriction enzyme res subunit
HB370_RS18360	COG3973	AAA domain
HB370_RS18395	COG1737	Transcriptional regulator
HB370_RS18400	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HB370_RS18425	COG1215	transferase activity, transferring glycosyl groups
HB370_RS18440	COG0459	protein refolding
HB370_RS18445	COG1278	Cold shock
HB370_RS18460	COG0463	Glycosyl transferase, family 2
HB370_RS18495	COG1105	Belongs to the carbohydrate kinase PfkB family
HB370_RS18505	COG5001	Diguanylate cyclase
HB370_RS18505	COG3300	MHYT domain
HB370_RS18525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HB370_RS18655	COG3842	ATPase activity
HB370_RS18680	COG0215	cysteine-tRNA ligase activity
HB370_RS18685	COG3467	pyridoxamine 5'-phosphate
HB370_RS18690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HB370_RS18695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HB370_RS18700	COG1329	Transcriptional regulator
HB370_RS18720	COG5002	protein histidine kinase activity
HB370_RS18800	COG0588	phosphoglycerate mutase activity
HB370_RS18835	COG0438	transferase activity, transferring glycosyl groups
HB370_RS18875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS18905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB370_RS18915	COG1309	transcriptional regulator
HB370_RS18925	COG1490	D-aminoacyl-tRNA deacylase activity
HB370_RS18935	COG0735	belongs to the Fur family
HB370_RS18940	COG3485	protocatechuate 3,4-dioxygenase
HB370_RS18980	COG2897	thiosulfate sulfurtransferase activity
HB370_RS19030	COG0745	RESPONSE REGULATOR receiver
HB370_RS19035	COG1609	Transcriptional regulator
HB370_RS19040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB370_RS19050	COG0745	RESPONSE REGULATOR receiver
HB370_RS19065	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB370_RS19070	COG3866	Pectate lyase
HB370_RS19115	COG0737	Belongs to the 5'-nucleotidase family
HB370_RS19120	COG0456	acetyltransferase
HB370_RS19150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HB370_RS19180	COG1937	Protein conserved in bacteria
HB370_RS19195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB370_RS19215	COG0277	FAD linked oxidase domain protein
HB370_RS19220	COG0671	phosphoesterase, PA-phosphatase related
HB370_RS19300	COG1252	NADH dehydrogenase
HB370_RS19330	COG0579	oxidoreductase
HB370_RS19335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB370_RS19345	COG0667	Aldo Keto reductase
HB370_RS19360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB370_RS19360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB370_RS19365	COG1846	Transcriptional regulator
HB370_RS19370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB370_RS19375	COG0477	Major facilitator Superfamily
HB370_RS19395	COG0137	argininosuccinate synthase activity
HB370_RS19410	COG0513	Belongs to the DEAD box helicase family
HB370_RS19460	COG1643	Atp-dependent helicase
HB370_RS19495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HB370_RS19515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB370_RS19520	COG0047	phosphoribosylformylglycinamidine synthase activity
HB370_RS19525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB370_RS19560	COG2197	response regulator
HB370_RS19570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HB370_RS19590	COG0151	Belongs to the GarS family
HB370_RS19685	COG0494	nUDIX hydrolase
HB370_RS19705	COG2372	response to copper ion
HB370_RS19705	COG1276	copper resistance
HB370_RS19710	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS19740	COG0433	COG0433 Predicted ATPase
HB370_RS19755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HB370_RS19790	COG1191	sigma factor activity
HB370_RS19795	COG1191	sigma factor activity
HB370_RS19815	COG2353	YceI-like domain
HB370_RS19820	COG3467	pyridoxamine 5'-phosphate
HB370_RS19830	COG0477	Major facilitator Superfamily
HB370_RS19835	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HB370_RS19845	COG2205	protein histidine kinase activity
HB370_RS19850	COG0745	RESPONSE REGULATOR receiver
HB370_RS19935	COG1309	transcriptional regulator
HB370_RS19940	COG2814	Major facilitator Superfamily
HB370_RS19945	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS19950	COG1595	DNA-templated transcription, initiation
HB370_RS20000	COG0653	protein targeting
HB370_RS20020	COG0006	proline dipeptidase activity
HB370_RS20040	COG1999	signal sequence binding
HB370_RS20065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HB370_RS20070	COG0561	phosphatase activity
HB370_RS20115	COG0561	phosphatase activity
HB370_RS20120	COG4988	ABC transporter
HB370_RS20125	COG1294	oxidase, subunit
HB370_RS20130	COG1271	oxidase subunit
HB370_RS20140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB370_RS20145	COG1609	Transcriptional regulator
HB370_RS20160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HB370_RS20185	COG0662	Cupin 2, conserved barrel domain protein
HB370_RS20190	COG1950	PFAM Membrane protein of
HB370_RS20195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB370_RS20200	COG0626	cystathionine gamma-synthase activity
HB370_RS20230	COG2814	Major facilitator Superfamily
HB370_RS20255	COG0305	Participates in initiation and elongation during chromosome replication
HB370_RS20265	COG0359	binds to the 23S rRNA
HB370_RS20270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HB370_RS20275	COG0629	single-stranded DNA binding
HB370_RS20280	COG0360	Binds together with S18 to 16S ribosomal RNA
HB370_RS20305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB370_RS20325	COG0617	tRNA 3'-terminal CCA addition
HB370_RS20340	COG0515	serine threonine protein kinase
HB370_RS20340	COG2815	serine threonine protein kinase
HB370_RS20345	COG1595	DNA-templated transcription, initiation
HB370_RS20355	COG0492	ferredoxin-NADP+ reductase activity
HB370_RS20360	COG3118	belongs to the thioredoxin family
HB370_RS20375	COG1192	Involved in chromosome partitioning
HB370_RS20380	COG0357	Ribosomal RNA small subunit methyltransferase G
HB370_RS20390	COG0706	membrane insertase activity
HB370_RS20395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HB370_RS20400	COG0594	ribonuclease P activity
HB370_RS20405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HB370_RS20415	COG0592	DNA-directed DNA polymerase activity
HB370_RS20420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HB370_RS20425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HB370_RS20430	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HB370_RS20435	COG0187	DNA topoisomerase II activity
HB370_RS20440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB370_RS20465	COG3467	pyridoxamine 5'-phosphate
HB370_RS20470	COG2319	Wd-40 repeat
HB370_RS20470	COG4249	Peptidase C14 caspase catalytic subunit p20
HB370_RS20505	COG0515	serine threonine protein kinase
HB370_RS20520	COG1917	Cupin 2, conserved barrel domain protein
HB370_RS20540	COG2814	Major facilitator Superfamily
HB370_RS20545	COG0596	Alpha beta hydrolase
HB370_RS20550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS20565	COG0705	Rhomboid family
HB370_RS20595	COG3764	Sortase (surface protein transpeptidase)
HB370_RS20600	COG3764	Sortase (surface protein transpeptidase)
HB370_RS20605	COG0515	serine threonine protein kinase
HB370_RS20610	COG0768	penicillin binding
HB370_RS20625	COG1716	ATPase activity
HB370_RS20630	COG1716	ATPase activity
HB370_RS20645	COG1309	transcriptional regulator
HB370_RS20670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB370_RS20675	COG2151	metal-sulfur cluster biosynthetic enzyme
HB370_RS20680	COG3396	Phenylacetate-CoA oxygenase
HB370_RS20685	COG3460	Phenylacetate-CoA oxygenase
HB370_RS20690	COG3396	Phenylacetate-CoA oxygenase
HB370_RS20715	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS20720	COG1309	transcriptional regulator
HB370_RS20725	COG1522	sequence-specific DNA binding
HB370_RS20745	COG0746	molybdenum cofactor guanylyltransferase activity
HB370_RS20760	COG0604	alcohol dehydrogenase
HB370_RS20760	COG3321	synthase
HB370_RS20760	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS20775	COG0515	serine threonine protein kinase
HB370_RS20780	COG0515	serine threonine protein kinase
HB370_RS20795	COG0022	dehydrogenase e1 component
HB370_RS20800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB370_RS20830	COG2814	Major facilitator Superfamily
HB370_RS20875	COG1362	aminopeptidase activity
HB370_RS20880	COG1960	acyl-CoA dehydrogenase activity
HB370_RS20895	COG1741	Belongs to the pirin family
HB370_RS20945	COG1595	DNA-templated transcription, initiation
HB370_RS20965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HB370_RS20975	COG3866	Pectate lyase
HB370_RS20980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB370_RS20990	COG1289	transmembrane transporter activity
HB370_RS20995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB370_RS21000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB370_RS21040	COG0366	Alpha amylase catalytic
HB370_RS21045	COG0640	Transcriptional regulator
HB370_RS21050	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HB370_RS21060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HB370_RS21070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB370_RS21090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB370_RS21115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB370_RS21125	COG1595	DNA-templated transcription, initiation
HB370_RS21135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB370_RS21150	COG0513	Belongs to the DEAD box helicase family
HB370_RS21155	COG1278	Cold shock
HB370_RS21270	COG3903	Transcriptional regulator
HB370_RS21270	COG3629	intracellular signal transduction
HB370_RS21300	COG0326	Molecular chaperone. Has ATPase activity
HB370_RS21305	COG0583	DNA-binding transcription factor activity
HB370_RS21310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS21365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HB370_RS21370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS21395	COG0513	Belongs to the DEAD box helicase family
HB370_RS21400	COG1278	Cold shock
HB370_RS21425	COG1366	Belongs to the anti-sigma-factor antagonist family
HB370_RS21435	COG2172	sigma factor antagonist activity
HB370_RS21450	COG1191	sigma factor activity
HB370_RS21530	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HB370_RS21535	COG3958	Transketolase
HB370_RS21540	COG3959	Transketolase, thiamine diphosphate binding domain
HB370_RS21545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB370_RS21550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HB370_RS21565	COG0189	ligase activity
HB370_RS21575	COG3629	intracellular signal transduction
HB370_RS21575	COG3903	Transcriptional regulator
HB370_RS21585	COG0509	glycine decarboxylation via glycine cleavage system
HB370_RS21615	COG2197	response regulator
HB370_RS21625	COG2409	Drug exporters of the RND superfamily
HB370_RS21640	COG0717	Belongs to the dCTP deaminase family
HB370_RS21645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HB370_RS21660	COG2181	nitrate reductase activity
HB370_RS21660	COG0247	lactate metabolic process
HB370_RS21665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB370_RS21670	COG0443	Heat shock 70 kDa protein
HB370_RS21675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HB370_RS21680	COG0484	heat shock protein binding
HB370_RS21685	COG0789	Transcriptional regulator
HB370_RS21690	COG4213	ABC transporter substrate-binding protein
HB370_RS21715	COG0542	response to heat
HB370_RS21740	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HB370_RS21755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HB370_RS21765	COG0477	Major facilitator Superfamily
HB370_RS21780	COG3844	kynureninase activity
HB370_RS21800	COG4585	Histidine kinase
HB370_RS21805	COG2197	response regulator
HB370_RS21820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB370_RS21830	COG1802	Transcriptional regulator
HB370_RS21850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HB370_RS21855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB370_RS21965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB370_RS21975	COG0640	Transcriptional regulator
HB370_RS21980	COG2814	Major facilitator Superfamily
HB370_RS22025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS22045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS22050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS22060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB370_RS22070	COG4770	biotin carboxylase activity
HB370_RS22080	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS22245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB370_RS22275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HB370_RS22345	COG1408	metallophosphoesterase
HB370_RS22370	COG0003	Pfam Anion-transporting ATPase
HB370_RS22395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB370_RS22425	COG2267	carboxylic ester hydrolase activity
HB370_RS22440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB370_RS22500	COG1205	dead DEAH box helicase
HB370_RS22500	COG1111	helicase
HB370_RS22505	COG1366	Belongs to the anti-sigma-factor antagonist family
HB370_RS22515	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HB370_RS22535	COG1754	DNA topoisomerase type I activity
HB370_RS22535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB370_RS22540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HB370_RS22550	COG0596	Alpha beta hydrolase
HB370_RS22560	COG3642	lipopolysaccharide core region biosynthetic process
HB370_RS22580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB370_RS22580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB370_RS22600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HB370_RS22605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HB370_RS22610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HB370_RS22615	COG0254	rRNA binding
HB370_RS22625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HB370_RS22645	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS22650	COG2318	DinB family
HB370_RS22660	COG0789	Transcriptional regulator
HB370_RS22665	COG0586	Pfam SNARE associated Golgi protein
HB370_RS22675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB370_RS22680	COG2027	D-alanyl-D-alanine carboxypeptidase
HB370_RS22690	COG0037	tRNA processing
HB370_RS22705	COG0302	gtp cyclohydrolase
HB370_RS22720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HB370_RS22735	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HB370_RS22735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HB370_RS22760	COG0649	NAD binding
HB370_RS22775	COG2197	response regulator
HB370_RS22800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HB370_RS22805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HB370_RS22815	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HB370_RS22835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HB370_RS22870	COG0739	heme binding
HB370_RS22885	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS22890	COG2205	protein histidine kinase activity
HB370_RS22895	COG0745	RESPONSE REGULATOR receiver
HB370_RS22905	COG1595	DNA-templated transcription, initiation
HB370_RS22920	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HB370_RS22940	COG0248	Ppx GppA phosphatase
HB370_RS22945	COG1082	Xylose isomerase domain protein TIM barrel
HB370_RS22950	COG1309	transcriptional regulator
HB370_RS22955	COG0129	dihydroxy-acid dehydratase activity
HB370_RS22965	COG4991	sh3 domain protein
HB370_RS22980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB370_RS22985	COG0180	Tryptophanyl-tRNA synthetase
HB370_RS23005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB370_RS23015	COG2223	nitrite transmembrane transporter activity
HB370_RS23020	COG0123	including yeast histone deacetylase and acetoin utilization protein
HB370_RS23070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HB370_RS23075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HB370_RS23080	COG0181	hydroxymethylbilane synthase activity
HB370_RS23085	COG1648	precorrin-2 dehydrogenase activity
HB370_RS23085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB370_RS23090	COG0113	porphobilinogen synthase activity
HB370_RS23150	COG0018	arginyl-trna synthetase
HB370_RS23155	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HB370_RS23175	COG1690	Belongs to the RtcB family
HB370_RS23195	COG1742	UPF0060 membrane protein
HB370_RS23200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS23205	COG0431	NADPH-dependent FMN reductase
HB370_RS23215	COG2205	protein histidine kinase activity
HB370_RS23230	COG2362	D-Aminopeptidase
HB370_RS23245	COG0583	DNA-binding transcription factor activity
HB370_RS23250	COG0697	spore germination
HB370_RS23255	COG0110	maltose O-acetyltransferase activity
HB370_RS23275	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HB370_RS23280	COG1937	Protein conserved in bacteria
HB370_RS23285	COG0730	response to heat
HB370_RS23295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB370_RS23295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HB370_RS23310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HB370_RS23315	COG0406	alpha-ribazole phosphatase activity
HB370_RS23330	COG0785	Cytochrome C biogenesis protein
HB370_RS23335	COG1333	cytochrome c biogenesis protein
HB370_RS23340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB370_RS23365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HB370_RS23375	COG0163	prenyltransferase activity
HB370_RS23385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HB370_RS23390	COG1573	uracil-dna glycosylase
HB370_RS23405	COG1309	transcriptional regulator
HB370_RS23465	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HB370_RS23475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HB370_RS23485	COG2226	methyltransferase
HB370_RS23500	COG0242	peptide deformylase activity
HB370_RS23515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS23520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS23525	COG0649	NAD binding
HB370_RS23535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB370_RS23540	COG1034	ATP synthesis coupled electron transport
HB370_RS23545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HB370_RS23550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS23555	COG0839	Belongs to the complex I subunit 6 family
HB370_RS23560	COG0713	ATP synthesis coupled electron transport
HB370_RS23565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB370_RS23575	COG1007	ATP synthesis coupled electron transport
HB370_RS23585	COG0514	ATP-dependent DNA helicase (RecQ)
HB370_RS23600	COG0561	phosphatase activity
HB370_RS23620	COG1131	(ABC) transporter
HB370_RS23645	COG0702	epimerase
HB370_RS23650	COG1733	regulation of RNA biosynthetic process
HB370_RS23655	COG1013	pyruvate-flavodoxin oxidoreductase activity
HB370_RS23660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HB370_RS23660	COG0674	pyruvate-flavodoxin oxidoreductase activity
HB370_RS23680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS23685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS23690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS23695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HB370_RS23700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS23705	COG0839	Belongs to the complex I subunit 6 family
HB370_RS23710	COG0713	ATP synthesis coupled electron transport
HB370_RS23725	COG1007	ATP synthesis coupled electron transport
HB370_RS23730	COG0501	Belongs to the peptidase M48B family
HB370_RS23735	COG3304	Inner membrane component domain
HB370_RS23745	COG2261	transglycosylase associated protein
HB370_RS23750	COG1666	GTP binding
HB370_RS23780	COG0702	epimerase
HB370_RS23785	COG0402	S-adenosylhomocysteine deaminase activity
HB370_RS23800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HB370_RS23805	COG2030	dehydratase
HB370_RS23815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HB370_RS23830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB370_RS23835	COG0436	Aminotransferase
HB370_RS23850	COG0250	Participates in transcription elongation, termination and antitermination
HB370_RS23860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HB370_RS23865	COG0081	regulation of translation
HB370_RS23885	COG0085	RNA polymerase activity
HB370_RS23890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HB370_RS23895	COG0501	Belongs to the peptidase M48B family
HB370_RS23925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HB370_RS23930	COG0049	tRNA binding
HB370_RS23935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB370_RS24055	COG0051	transcription antitermination factor activity, RNA binding
HB370_RS24060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HB370_RS24065	COG0088	Forms part of the polypeptide exit tunnel
HB370_RS24070	COG0089	rRNA binding
HB370_RS24075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HB370_RS24080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HB370_RS24085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HB370_RS24090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HB370_RS24095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HB370_RS24100	COG0255	Belongs to the universal ribosomal protein uL29 family
HB370_RS24105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HB370_RS24110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HB370_RS24115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HB370_RS24120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HB370_RS24125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HB370_RS24135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HB370_RS24140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HB370_RS24145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HB370_RS24150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HB370_RS24155	COG1841	ribosomal large subunit assembly
HB370_RS24160	COG0200	Binds to the 23S rRNA
HB370_RS24170	COG0563	adenylate kinase activity
HB370_RS24185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HB370_RS24190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HB370_RS24195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HB370_RS24200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HB370_RS24205	COG0202	RNA polymerase activity
HB370_RS24210	COG0203	ribosomal protein L17
HB370_RS24215	COG0101	tRNA pseudouridine synthase activity
HB370_RS24235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB370_RS24240	COG0463	Glycosyl transferase, family 2
HB370_RS24250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HB370_RS24255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB370_RS24260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB370_RS24270	COG1072	(Pantothenic acid kinase))
HB370_RS24285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB370_RS24295	COG0736	holo-[acyl-carrier-protein] synthase activity
HB370_RS24305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB370_RS24315	COG0802	atpase or kinase
HB370_RS24335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HB370_RS24345	COG1609	Transcriptional regulator
HB370_RS24350	COG1316	TRANSCRIPTIONal
HB370_RS24360	COG4941	Belongs to the sigma-70 factor family
HB370_RS24370	COG0726	polysaccharide deacetylase
HB370_RS24375	COG0726	polysaccharide deacetylase
HB370_RS24385	COG0459	protein refolding
HB370_RS24395	COG4221	oxidoreductase activity
HB370_RS24405	COG0583	DNA-binding transcription factor activity
HB370_RS24420	COG1595	DNA-templated transcription, initiation
HB370_RS24430	COG0516	GMP reductase activity
HB370_RS24440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HB370_RS24450	COG2815	serine threonine protein kinase
HB370_RS24450	COG0515	serine threonine protein kinase
HB370_RS24455	COG0515	serine threonine protein kinase
HB370_RS24460	COG0515	serine threonine protein kinase
HB370_RS24465	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS24480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB370_RS24480	COG0519	Catalyzes the synthesis of GMP from XMP
HB370_RS24515	COG2197	response regulator
HB370_RS24530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HB370_RS24545	COG0739	heme binding
HB370_RS24555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS24555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS24570	COG0714	Associated with various cellular activities
HB370_RS24575	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HB370_RS24580	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HB370_RS24585	COG0045	succinate-CoA ligase (ADP-forming) activity
HB370_RS24615	COG0138	bifunctional purine biosynthesis protein purh
HB370_RS24625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HB370_RS24640	COG0039	L-malate dehydrogenase activity
HB370_RS24650	COG0477	Major facilitator Superfamily
HB370_RS24660	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS24675	COG4176	ABC-type proline glycine betaine transport system permease component
HB370_RS24690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB370_RS24695	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB370_RS24700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB370_RS24710	COG0754	glutathionylspermidine amidase activity
HB370_RS24725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB370_RS24730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB370_RS24735	COG0180	Tryptophanyl-tRNA synthetase
HB370_RS24750	COG1295	ribonuclease BN
HB370_RS24770	COG1309	transcriptional regulator
HB370_RS24795	COG1053	succinate dehydrogenase
HB370_RS24805	COG2009	succinate dehydrogenase
HB370_RS24815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HB370_RS24840	COG1595	DNA-templated transcription, initiation
HB370_RS24855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS24855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS24875	COG1216	Glycosyl transferase, family 2
HB370_RS24890	COG1216	Glycosyl transferase, family 2
HB370_RS24900	COG1083	cytidylyl-transferase
HB370_RS24905	COG2089	acid synthase
HB370_RS24915	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HB370_RS24915	COG1473	amidohydrolase
HB370_RS24965	COG2814	Major facilitator Superfamily
HB370_RS24970	COG0583	DNA-binding transcription factor activity
HB370_RS24985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB370_RS25010	COG2205	protein histidine kinase activity
HB370_RS25015	COG0745	RESPONSE REGULATOR receiver
HB370_RS25020	COG1595	DNA-templated transcription, initiation
HB370_RS25035	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS25040	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS25055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB370_RS25075	COG1349	DNA-binding transcription factor activity
HB370_RS25080	COG4770	biotin carboxylase activity
HB370_RS25090	COG0424	maF-like protein
HB370_RS25100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB370_RS25110	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HB370_RS25115	COG1024	Enoyl-CoA hydratase
HB370_RS25125	COG2986	histidine ammonia-lyase
HB370_RS25155	COG1404	Belongs to the peptidase S8 family
HB370_RS25170	COG1064	alcohol dehydrogenase
HB370_RS25180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB370_RS25190	COG0501	Belongs to the peptidase M48B family
HB370_RS25215	COG2255	four-way junction helicase activity
HB370_RS25220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB370_RS25235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB370_RS25245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB370_RS25255	COG1331	Highly conserved protein containing a thioredoxin domain
HB370_RS25270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HB370_RS25280	COG0436	Aminotransferase
HB370_RS25300	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HB370_RS25315	COG1414	Transcriptional regulator
HB370_RS25320	COG0251	oxidation-reduction process
HB370_RS25325	COG2610	gluconate transmembrane transporter activity
HB370_RS25370	COG3209	COG3209 Rhs family protein
HB370_RS25405	COG2894	cell division
HB370_RS25435	COG3851	Histidine kinase
HB370_RS25460	COG3047	cAMP biosynthetic process
HB370_RS25460	COG2885	chlorophyll binding
HB370_RS25475	COG2226	methyltransferase
HB370_RS25480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB370_RS25485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HB370_RS25490	COG0741	lytic transglycosylase activity
HB370_RS25500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB370_RS25505	COG0450	alkyl hydroperoxide reductase
HB370_RS25520	COG1136	(ABC) transporter
HB370_RS25540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB370_RS25555	COG0114	fumarate hydratase activity
HB370_RS25565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB370_RS25565	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB370_RS25595	COG0778	Nitroreductase
HB370_RS25600	COG1722	exodeoxyribonuclease VII activity
HB370_RS25605	COG1570	exodeoxyribonuclease VII activity
HB370_RS25615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HB370_RS25630	COG0012	GTP binding
HB370_RS25660	COG3321	synthase
HB370_RS25660	COG0604	alcohol dehydrogenase
HB370_RS25660	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS25680	COG1082	Xylose isomerase domain protein TIM barrel
HB370_RS25700	COG0492	ferredoxin-NADP+ reductase activity
HB370_RS25715	COG2197	response regulator
HB370_RS25720	COG4585	Histidine kinase
HB370_RS25765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS25770	COG1960	acyl-CoA dehydrogenase activity
HB370_RS25780	COG0252	asparaginase activity
HB370_RS25785	COG2175	clavaminate synthase activity
HB370_RS25795	COG0475	glutathione-regulated potassium exporter activity
HB370_RS25815	COG1136	(ABC) transporter
HB370_RS25815	COG0577	efflux transmembrane transporter activity
HB370_RS25825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HB370_RS25840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB370_RS25895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB370_RS25930	COG4166	transmembrane transport
HB370_RS25935	COG0601	transmembrane transport
HB370_RS25940	COG0444	Belongs to the ABC transporter superfamily
HB370_RS25945	COG4608	Belongs to the ABC transporter superfamily
HB370_RS25955	COG4608	Belongs to the ABC transporter superfamily
HB370_RS25960	COG0444	Belongs to the ABC transporter superfamily
HB370_RS25970	COG0747	negative chemotaxis
HB370_RS25975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB370_RS25985	COG0601	transmembrane transport
HB370_RS26000	COG4608	Belongs to the ABC transporter superfamily
HB370_RS26015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB370_RS26030	COG1131	(ABC) transporter
HB370_RS26040	COG4585	Histidine kinase
HB370_RS26045	COG2197	response regulator
HB370_RS26080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB370_RS26090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB370_RS26100	COG0519	Catalyzes the synthesis of GMP from XMP
HB370_RS26105	COG1024	Enoyl-CoA hydratase
HB370_RS26120	COG1595	DNA-templated transcription, initiation
HB370_RS26140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB370_RS26175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB370_RS26185	COG0598	Magnesium transport protein CorA
HB370_RS26195	COG2814	Major facilitator Superfamily
HB370_RS26210	COG2095	MarC family integral membrane protein
HB370_RS26220	COG1432	Conserved Protein
HB370_RS26230	COG0513	Belongs to the DEAD box helicase family
HB370_RS26280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB370_RS26290	COG4172	Belongs to the ABC transporter superfamily
HB370_RS26355	COG0210	DNA helicase
HB370_RS26360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB370_RS26365	COG2816	NAD+ diphosphatase activity
HB370_RS26395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB370_RS26450	COG3480	Lon protease (S16) C-terminal proteolytic domain
HB370_RS26460	COG1615	UPF0182 protein
HB370_RS26485	COG0753	catalase activity
HB370_RS26495	COG0483	inositol monophosphate 1-phosphatase activity
HB370_RS26505	COG2076	Multidrug Resistance protein
HB370_RS26515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB370_RS26525	COG2135	peptidase activity
HB370_RS26535	COG1595	DNA-templated transcription, initiation
HB370_RS26540	COG5662	AntiSigma factor
HB370_RS26560	COG0242	peptide deformylase activity
HB370_RS26570	COG2124	cytochrome p450
HB370_RS26610	COG2188	Transcriptional regulator
HB370_RS26615	COG0363	glucosamine-6-phosphate deaminase activity
HB370_RS26620	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS26640	COG1597	lipid kinase activity
HB370_RS26655	COG2172	sigma factor antagonist activity
HB370_RS26685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB370_RS26725	COG4106	trans-aconitate 2-methyltransferase activity
HB370_RS26730	COG1126	abc transporter atp-binding protein
HB370_RS26745	COG0281	malic enzyme
HB370_RS26750	COG0604	alcohol dehydrogenase
HB370_RS26780	COG0567	Dehydrogenase, E1 component
HB370_RS26780	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB370_RS26785	COG2205	protein histidine kinase activity
HB370_RS26790	COG0745	RESPONSE REGULATOR receiver
HB370_RS26800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HB370_RS26855	COG0791	NLP P60 protein
HB370_RS26895	COG2205	protein histidine kinase activity
HB370_RS26915	COG3285	dna ligase
HB370_RS26915	COG1793	dna ligase
HB370_RS26920	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB370_RS26930	COG0640	Transcriptional regulator
HB370_RS26955	COG0018	arginyl-trna synthetase
HB370_RS26960	COG0019	diaminopimelate decarboxylase activity
HB370_RS26965	COG0460	homoserine dehydrogenase
HB370_RS26970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB370_RS26975	COG0083	homoserine kinase activity
HB370_RS26985	COG1316	TRANSCRIPTIONal
HB370_RS26990	COG0254	rRNA binding
HB370_RS26995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HB370_RS27000	COG2890	protein-(glutamine-N5) methyltransferase activity
HB370_RS27010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB370_RS27015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB370_RS27020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB370_RS27035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HB370_RS27040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HB370_RS27045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HB370_RS27050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HB370_RS27055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HB370_RS27060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HB370_RS27065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HB370_RS27080	COG2197	response regulator
HB370_RS27085	COG4585	Histidine kinase
HB370_RS27115	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS27130	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HB370_RS27175	COG0183	Belongs to the thiolase family
HB370_RS27255	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS27255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS27290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB370_RS27295	COG0280	phosphate acetyltransferase
HB370_RS27295	COG0857	belongs to the CobB CobQ family
HB370_RS27300	COG0205	6-phosphofructokinase activity
HB370_RS27310	COG0395	ABC-type sugar transport system, permease component
HB370_RS27315	COG1175	transmembrane transport
HB370_RS27325	COG4565	transcriptional regulatory protein
HB370_RS27335	COG1301	dicarboxylic acid transport
HB370_RS27345	COG0477	Major facilitator Superfamily
HB370_RS27365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB370_RS27370	COG3281	Trehalose synthase
HB370_RS27380	COG0366	Alpha amylase catalytic
HB370_RS27385	COG0058	SHG alpha-glucan phosphorylase activity
HB370_RS27405	COG1132	(ABC) transporter
HB370_RS27410	COG1132	(ABC) transporter
HB370_RS27430	COG2192	nodulation
HB370_RS27470	COG1215	transferase activity, transferring glycosyl groups
HB370_RS27490	COG1376	ErfK ybiS ycfS ynhG family protein
HB370_RS27500	COG1024	Enoyl-CoA hydratase
HB370_RS27525	COG1119	ATPase activity
HB370_RS27530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB370_RS27550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB370_RS27575	COG1760	l-serine dehydratase
HB370_RS27580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB370_RS27585	COG0509	glycine decarboxylation via glycine cleavage system
HB370_RS27590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB370_RS27610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB370_RS27615	COG0747	negative chemotaxis
HB370_RS27625	COG0444	Belongs to the ABC transporter superfamily
HB370_RS27640	COG2860	membrane
HB370_RS27645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB370_RS27660	COG2378	regulation of single-species biofilm formation
HB370_RS27690	COG0482	sulfurtransferase activity
HB370_RS27705	COG1611	Belongs to the LOG family
HB370_RS27710	COG4221	oxidoreductase activity
HB370_RS27720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HB370_RS27735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB370_RS27740	COG0154	amidase activity
HB370_RS27750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB370_RS27755	COG2226	methyltransferase
HB370_RS27765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB370_RS27780	COG2197	response regulator
HB370_RS27790	COG2133	pyrroloquinoline quinone binding
HB370_RS27795	COG0667	Aldo Keto reductase
HB370_RS27810	COG5001	Diguanylate cyclase
HB370_RS27820	COG0440	acetolactate synthase activity
HB370_RS27825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HB370_RS27830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB370_RS27835	COG0477	Major facilitator Superfamily
HB370_RS27850	COG3835	regulator
HB370_RS27855	COG0506	proline dehydrogenase activity
HB370_RS27860	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS27870	COG0473	3-isopropylmalate dehydrogenase activity
HB370_RS27875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB370_RS27885	COG0832	Belongs to the urease beta subunit family
HB370_RS27885	COG0831	urea catabolic process
HB370_RS27890	COG0804	urea catabolic process
HB370_RS27895	COG2957	Belongs to the agmatine deiminase family
HB370_RS27905	COG0477	Major facilitator Superfamily
HB370_RS27910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB370_RS27930	COG1472	Belongs to the glycosyl hydrolase 3 family
HB370_RS27960	COG2197	response regulator
HB370_RS27965	COG4585	Histidine kinase
HB370_RS27975	COG1136	(ABC) transporter
HB370_RS27980	COG2353	YceI-like domain
HB370_RS27990	COG5492	domain, Protein
HB370_RS27995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB370_RS28020	COG2018	Roadblock/LC7 domain
HB370_RS28040	COG2018	Roadblock/LC7 domain
HB370_RS28045	COG5002	protein histidine kinase activity
HB370_RS28055	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB370_RS28060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB370_RS28105	COG1414	Transcriptional regulator
HB370_RS28110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HB370_RS28115	COG0066	3-isopropylmalate dehydratase activity
HB370_RS28125	COG0776	regulation of translation
HB370_RS28135	COG1920	GTP binding
HB370_RS28145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HB370_RS28150	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB370_RS28170	COG0351	phosphomethylpyrimidine kinase
HB370_RS28175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HB370_RS28180	COG1461	Dihydroxyacetone kinase
HB370_RS28200	COG0742	ribosomal rna small subunit methyltransferase
HB370_RS28205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HB370_RS28220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HB370_RS28225	COG0571	ribonuclease III activity
HB370_RS28230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HB370_RS28235	COG1733	regulation of RNA biosynthetic process
HB370_RS28240	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB370_RS28250	COG1254	Belongs to the acylphosphatase family
HB370_RS28265	COG1196	nuclear chromosome segregation
HB370_RS28270	COG0477	Major facilitator Superfamily
HB370_RS28310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HB370_RS28320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB370_RS28335	COG0228	four-way junction DNA binding
HB370_RS28340	COG1837	Belongs to the UPF0109 family
HB370_RS28345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB370_RS28350	COG0336	Belongs to the RNA methyltransferase TrmD family
HB370_RS28355	COG0335	large ribosomal subunit rRNA binding
HB370_RS28370	COG0681	Belongs to the peptidase S26 family
HB370_RS28375	COG0681	Belongs to the peptidase S26 family
HB370_RS28390	COG0792	nuclease activity
HB370_RS28405	COG1191	sigma factor activity
HB370_RS28415	COG4942	peptidase
HB370_RS28420	COG0052	Belongs to the universal ribosomal protein uS2 family
HB370_RS28425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HB370_RS28430	COG0528	UMP kinase activity
HB370_RS28435	COG0233	cytoplasmic translational termination
HB370_RS28440	COG0575	Belongs to the CDS family
HB370_RS28445	COG2124	cytochrome p450
HB370_RS28450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HB370_RS28460	COG4208	sulfate ABC transporter
HB370_RS28465	COG3842	ATPase activity
HB370_RS28485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB370_RS28495	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS28500	COG0667	Aldo Keto reductase
HB370_RS28520	COG1414	Transcriptional regulator
HB370_RS28540	COG1733	regulation of RNA biosynthetic process
HB370_RS28550	COG0584	glycerophosphoryl diester phosphodiesterase
HB370_RS28555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB370_RS28580	COG3842	ATPase activity
HB370_RS28585	COG1176	ABC-type spermidine putrescine transport system, permease component I
HB370_RS28590	COG1177	transmembrane transport
HB370_RS28595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB370_RS28625	COG2508	Transcriptional regulator
HB370_RS28630	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS28660	COG4209	transmembrane transport
HB370_RS28665	COG0395	ABC-type sugar transport system, permease component
HB370_RS28705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HB370_RS28710	COG0750	zinc metalloprotease
HB370_RS28715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HB370_RS28755	COG1247	-acetyltransferase
HB370_RS28760	COG0442	prolyl-tRNA aminoacylation
HB370_RS28785	COG0779	Required for maturation of 30S ribosomal subunits
HB370_RS28800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HB370_RS28810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HB370_RS28815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB370_RS28850	COG1404	Belongs to the peptidase S8 family
HB370_RS28895	COG1404	Belongs to the peptidase S8 family
HB370_RS28925	COG1674	ftsk spoiiie
HB370_RS28945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HB370_RS28950	COG1185	polyribonucleotide nucleotidyltransferase activity
HB370_RS28955	COG0612	Peptidase, M16
HB370_RS28960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HB370_RS28980	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HB370_RS28985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS28990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HB370_RS29020	COG2208	phosphoserine phosphatase activity
HB370_RS29020	COG2770	Histidine kinase
HB370_RS29030	COG3437	response regulator, receiver
HB370_RS29030	COG3850	Histidine kinase
HB370_RS29030	COG2205	protein histidine kinase activity
HB370_RS29030	COG4999	Histidine kinase
HB370_RS29040	COG1674	ftsk spoiiie
HB370_RS29050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB370_RS29060	COG1058	Belongs to the CinA family
HB370_RS29060	COG1546	Belongs to the CinA family
HB370_RS29065	COG1396	sequence-specific DNA binding
HB370_RS29070	COG0783	Belongs to the Dps family
HB370_RS29080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HB370_RS29085	COG1201	RNA secondary structure unwinding
HB370_RS29115	COG0628	permease
HB370_RS29155	COG0765	amino acid transport
HB370_RS29160	COG0765	amino acid transport
HB370_RS29165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB370_RS29170	COG1126	abc transporter atp-binding protein
HB370_RS29175	COG0745	RESPONSE REGULATOR receiver
HB370_RS29180	COG2205	protein histidine kinase activity
HB370_RS29205	COG0475	glutathione-regulated potassium exporter activity
HB370_RS29240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB370_RS29255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HB370_RS29265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HB370_RS29275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB370_RS29285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB370_RS29320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB370_RS29325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HB370_RS29330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB370_RS29345	COG0588	phosphoglycerate mutase activity
HB370_RS29365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB370_RS29405	COG1802	Transcriptional regulator
HB370_RS29410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB370_RS29425	COG0187	DNA topoisomerase II activity
HB370_RS29440	COG2197	response regulator
HB370_RS29445	COG4565	transcriptional regulatory protein
HB370_RS29450	COG3290	protein histidine kinase activity
HB370_RS29465	COG0523	cobalamin synthesis protein
HB370_RS29470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB370_RS29475	COG0612	Peptidase, M16
HB370_RS29490	COG1802	Transcriptional regulator
HB370_RS29495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB370_RS29505	COG1042	CoA-binding domain protein
HB370_RS29505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB370_RS29505	COG0045	succinate-CoA ligase (ADP-forming) activity
HB370_RS29520	COG1435	thymidine kinase activity
HB370_RS29570	COG0745	RESPONSE REGULATOR receiver
HB370_RS29575	COG2205	protein histidine kinase activity
HB370_RS29600	COG0756	dUTP diphosphatase activity
HB370_RS29615	COG3547	Transposase (IS116 IS110 IS902 family)
HB370_RS29645	COG0569	domain protein
HB370_RS29650	COG0531	amino acid
HB370_RS29655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB370_RS29665	COG1309	transcriptional regulator
HB370_RS29700	COG0596	Alpha beta hydrolase
HB370_RS29705	COG2208	phosphoserine phosphatase activity
HB370_RS29705	COG2770	Histidine kinase
HB370_RS29735	COG0640	Transcriptional regulator
HB370_RS29760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB370_RS29775	COG1522	sequence-specific DNA binding
HB370_RS29780	COG0525	valine-tRNA ligase activity
HB370_RS29785	COG3693	PFAM glycoside hydrolase, family 10
HB370_RS29855	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HB370_RS29860	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB370_RS29870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB370_RS29880	COG2205	protein histidine kinase activity
HB370_RS29885	COG0745	RESPONSE REGULATOR receiver
HB370_RS29890	COG3401	FG-GAP repeat protein
HB370_RS29935	COG1799	cell septum assembly
HB370_RS29985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB370_RS30030	COG2235	arginine
HB370_RS30035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HB370_RS30040	COG0531	amino acid
HB370_RS30060	COG2188	Transcriptional regulator
HB370_RS30065	COG2182	Extracellular solute-binding protein
HB370_RS30070	COG1175	transmembrane transport
HB370_RS30075	COG0395	ABC-type sugar transport system, permease component
HB370_RS30080	COG1472	Belongs to the glycosyl hydrolase 3 family
HB370_RS30110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB370_RS30145	COG3361	conserved protein (COG2071)
HB370_RS30160	COG1414	Transcriptional regulator
HB370_RS30175	COG2814	Major facilitator Superfamily
HB370_RS30190	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS30195	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS30200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB370_RS30215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB370_RS30220	COG0395	ABC-type sugar transport system, permease component
HB370_RS30225	COG1175	transmembrane transport
HB370_RS30235	COG3250	beta-galactosidase activity
HB370_RS30240	COG1609	Transcriptional regulator
HB370_RS30260	COG3397	chitin binding
HB370_RS30265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB370_RS30280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB370_RS30290	COG3629	intracellular signal transduction
HB370_RS30290	COG3903	Transcriptional regulator
HB370_RS30300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB370_RS30305	COG0604	alcohol dehydrogenase
HB370_RS30330	COG1653	transport
HB370_RS30335	COG1175	transmembrane transport
HB370_RS30340	COG0395	ABC-type sugar transport system, permease component
HB370_RS30345	COG1940	carbohydrate kinase activity
HB370_RS30350	COG4213	ABC transporter substrate-binding protein
HB370_RS30360	COG4214	carbohydrate transport
HB370_RS30365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HB370_RS30370	COG0531	amino acid
HB370_RS30390	COG1024	Enoyl-CoA hydratase
HB370_RS30390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS30395	COG0183	Belongs to the thiolase family
HB370_RS30400	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS30425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HB370_RS30435	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB370_RS30460	COG3220	belongs to the UPF0276 family
HB370_RS30465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB370_RS30470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB370_RS30475	COG1960	acyl-CoA dehydrogenase activity
HB370_RS30485	COG0367	asparagine synthase
HB370_RS30515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB370_RS30520	COG2313	pseudouridylate synthase activity
HB370_RS30565	COG1121	(ABC) transporter
HB370_RS30585	COG0723	plastoquinol--plastocyanin reductase activity
HB370_RS30585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB370_RS30590	COG0330	HflC and HflK could
HB370_RS30625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB370_RS30630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB370_RS30645	COG1174	glycine betaine transport
HB370_RS30660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB370_RS30770	COG1175	transmembrane transport
HB370_RS30805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB370_RS30805	COG1116	anion transmembrane transporter activity
HB370_RS30830	COG0529	Catalyzes the synthesis of activated sulfate
HB370_RS30835	COG0175	sulfate reduction
HB370_RS30850	COG0456	acetyltransferase
HB370_RS30865	COG1960	acyl-CoA dehydrogenase activity
HB370_RS30910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HB370_RS30925	COG1609	Transcriptional regulator
HB370_RS30930	COG0789	Transcriptional regulator
HB370_RS30945	COG2040	homocysteine
HB370_RS30965	COG2755	lipolytic protein G-D-S-L family
HB370_RS31000	COG0395	ABC-type sugar transport system, permease component
HB370_RS31005	COG1175	transmembrane transport
HB370_RS31020	COG0277	FAD linked oxidase domain protein
HB370_RS31035	COG1162	GTPase activity
HB370_RS31050	COG1683	Conserved Protein
HB370_RS31090	COG0028	Belongs to the TPP enzyme family
HB370_RS31110	COG1802	Transcriptional regulator
HB370_RS31130	COG2252	PERMEase
HB370_RS31140	COG0726	polysaccharide deacetylase
HB370_RS31150	COG0515	serine threonine protein kinase
HB370_RS31165	COG1653	transport
HB370_RS31180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB370_RS31185	COG1063	alcohol dehydrogenase
HB370_RS31190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB370_RS31210	COG2814	Major facilitator Superfamily
HB370_RS31220	COG3835	regulator
HB370_RS31225	COG3960	tartronate-semialdehyde synthase activity
HB370_RS31235	COG0753	catalase activity
HB370_RS31240	COG2084	Dehydrogenase
HB370_RS31245	COG3622	Belongs to the hyi family
HB370_RS31265	COG2351	hydroxyisourate hydrolase activity
HB370_RS31275	COG2233	PERMEase
HB370_RS31285	COG2233	PERMEase
HB370_RS31305	COG0406	alpha-ribazole phosphatase activity
HB370_RS31320	COG0436	Aminotransferase
HB370_RS31325	COG1733	regulation of RNA biosynthetic process
HB370_RS31340	COG4264	IucA IucC family
HB370_RS31355	COG0494	nUDIX hydrolase
HB370_RS31375	COG1595	DNA-templated transcription, initiation
HB370_RS31405	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HB370_RS31405	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HB370_RS31420	COG1414	Transcriptional regulator
HB370_RS31425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB370_RS31430	COG4266	Belongs to the allantoicase family
HB370_RS31455	COG2197	response regulator
HB370_RS31460	COG2188	Transcriptional regulator
HB370_RS31470	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB370_RS31480	COG1940	carbohydrate kinase activity
HB370_RS31490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HB370_RS31585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB370_RS31660	COG2124	cytochrome p450
HB370_RS31665	COG1819	glycosyl
HB370_RS31670	COG1819	glycosyl
HB370_RS31690	COG0488	(ABC) transporter
HB370_RS31700	COG2211	Major facilitator Superfamily
HB370_RS31705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB370_RS31725	COG1309	transcriptional regulator
HB370_RS31735	COG0583	DNA-binding transcription factor activity
HB370_RS31765	COG1126	abc transporter atp-binding protein
HB370_RS31775	COG0765	amino acid transport
HB370_RS31780	COG0765	amino acid transport
HB370_RS31785	COG0405	Gamma-glutamyltransferase
HB370_RS31790	COG0542	response to heat
HB370_RS31810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB370_RS31820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB370_RS31825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS31845	COG0095	Lipoate-protein ligase
HB370_RS31855	COG0483	inositol monophosphate 1-phosphatase activity
HB370_RS31885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB370_RS31900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB370_RS31920	COG1929	Belongs to the glycerate kinase type-1 family
HB370_RS31930	COG0688	phosphatidylethanolamine metabolic process
HB370_RS31935	COG1960	acyl-CoA dehydrogenase activity
HB370_RS31945	COG2301	Belongs to the HpcH HpaI aldolase family
HB370_RS31950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS31950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HB370_RS31965	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS31980	COG0596	Alpha beta hydrolase
HB370_RS32000	COG3629	intracellular signal transduction
HB370_RS32020	COG1011	Hydrolase
HB370_RS32035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB370_RS32040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS32045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS32050	COG1233	COG1233 Phytoene dehydrogenase and related
HB370_RS32055	COG2197	response regulator
HB370_RS32060	COG4585	Histidine kinase
HB370_RS32060	COG2203	Gaf domain
HB370_RS32090	COG0667	Aldo Keto reductase
HB370_RS32095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB370_RS32100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS32105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS32110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB370_RS32115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS32120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB370_RS32125	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS32130	COG0736	holo-[acyl-carrier-protein] synthase activity
HB370_RS32135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB370_RS32145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB370_RS32155	COG4770	biotin carboxylase activity
HB370_RS32175	COG4106	trans-aconitate 2-methyltransferase activity
HB370_RS32180	COG2362	D-Aminopeptidase
HB370_RS32185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB370_RS32195	COG1619	proteins homologs of microcin C7 resistance protein MccF
HB370_RS32215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS32300	COG0406	alpha-ribazole phosphatase activity
HB370_RS32305	COG0488	(ABC) transporter
HB370_RS32335	COG0028	Belongs to the TPP enzyme family
HB370_RS32360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HB370_RS32390	COG1140	nitrate reductase beta subunit
HB370_RS32415	COG2154	pterin-4-alpha-carbinolamine dehydratase
HB370_RS32420	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HB370_RS32420	COG4106	trans-aconitate 2-methyltransferase activity
HB370_RS32435	COG5297	Belongs to the glycosyl hydrolase family 6
HB370_RS32435	COG4733	cellulase activity
HB370_RS32440	COG5297	Belongs to the glycosyl hydrolase family 6
HB370_RS32445	COG4106	trans-aconitate 2-methyltransferase activity
HB370_RS32465	COG0656	L-ascorbic acid biosynthetic process
HB370_RS32510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB370_RS32515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB370_RS32535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB370_RS32555	COG1309	transcriptional regulator
HB370_RS32565	COG2182	Extracellular solute-binding protein
HB370_RS32570	COG1175	transmembrane transport
HB370_RS32575	COG0395	ABC-type sugar transport system, permease component
HB370_RS32580	COG2723	6-phospho-beta-galactosidase activity
HB370_RS32585	COG2273	Hydrolase Family 16
HB370_RS32615	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS32620	COG0129	dihydroxy-acid dehydratase activity
HB370_RS32630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HB370_RS32645	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS32650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB370_RS32665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HB370_RS32670	COG1960	acyl-CoA dehydrogenase activity
HB370_RS32675	COG1960	acyl-CoA dehydrogenase activity
HB370_RS32680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HB370_RS32690	COG2186	Transcriptional regulator
HB370_RS32700	COG2814	Major facilitator Superfamily
HB370_RS32710	COG0747	negative chemotaxis
HB370_RS32715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB370_RS32740	COG0297	glycogen (starch) synthase activity
HB370_RS32760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB370_RS32775	COG0477	Major facilitator Superfamily
HB370_RS32785	COG3467	pyridoxamine 5'-phosphate
HB370_RS32790	COG2084	Dehydrogenase
HB370_RS32820	COG2226	methyltransferase
HB370_RS32840	COG0588	phosphoglycerate mutase activity
HB370_RS32845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HB370_RS32850	COG0166	Belongs to the GPI family
HB370_RS32865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB370_RS32895	COG2814	Major facilitator Superfamily
HB370_RS32915	COG1486	melibiose metabolic process
HB370_RS32925	COG2197	response regulator
HB370_RS32985	COG1175	transmembrane transport
HB370_RS32990	COG0395	ABC-type sugar transport system, permease component
HB370_RS32995	COG0366	Alpha amylase catalytic
HB370_RS33005	COG0477	Major facilitator Superfamily
HB370_RS33010	COG3511	phospholipase C
HB370_RS33065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB370_RS33070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB370_RS33075	COG3485	protocatechuate 3,4-dioxygenase
HB370_RS33080	COG3485	protocatechuate 3,4-dioxygenase
HB370_RS33085	COG0183	Belongs to the thiolase family
HB370_RS33110	COG1793	dna ligase
HB370_RS33120	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS33125	COG0302	gtp cyclohydrolase
HB370_RS33155	COG1834	amidinotransferase
HB370_RS33160	COG0488	(ABC) transporter
HB370_RS33185	COG1515	deoxyribonuclease V activity
HB370_RS33190	COG3268	Saccharopine dehydrogenase
HB370_RS33195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB370_RS33200	COG0183	Belongs to the thiolase family
HB370_RS33205	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS33205	COG1024	Enoyl-CoA hydratase
HB370_RS33215	COG1113	amino acid transport
HB370_RS33225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS33235	COG2936	dipeptidyl-peptidase activity
HB370_RS33245	COG0488	(ABC) transporter
HB370_RS33250	COG2318	DinB family
HB370_RS33255	COG2183	response to ionizing radiation
HB370_RS33260	COG1024	Enoyl-CoA hydratase
HB370_RS33270	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HB370_RS33310	COG1134	teichoic acid transport
HB370_RS33315	COG1562	ergosterol biosynthetic process
HB370_RS33325	COG1233	COG1233 Phytoene dehydrogenase and related
HB370_RS33335	COG1657	PFAM Prenyltransferase squalene oxidase
HB370_RS33350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HB370_RS33355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HB370_RS33385	COG2755	lipolytic protein G-D-S-L family
HB370_RS33395	COG2267	carboxylic ester hydrolase activity
HB370_RS33420	COG2814	Major facilitator Superfamily
HB370_RS33425	COG2259	Doxx family
HB370_RS33430	COG1335	isochorismatase
HB370_RS33435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HB370_RS33450	COG3629	intracellular signal transduction
HB370_RS33450	COG3903	Transcriptional regulator
HB370_RS33485	COG1063	alcohol dehydrogenase
HB370_RS33490	COG0156	8-amino-7-oxononanoate synthase activity
HB370_RS33495	COG0583	DNA-binding transcription factor activity
HB370_RS33520	COG3958	Transketolase
HB370_RS33525	COG3959	Transketolase, thiamine diphosphate binding domain
HB370_RS33560	COG2226	methyltransferase
HB370_RS33570	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB370_RS33585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS33615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS33655	COG4770	biotin carboxylase activity
HB370_RS33665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB370_RS33675	COG2197	response regulator
HB370_RS33680	COG4585	Histidine kinase
HB370_RS33705	COG1846	Transcriptional regulator
HB370_RS33715	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS33720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB370_RS33760	COG0561	phosphatase activity
HB370_RS33780	COG2267	carboxylic ester hydrolase activity
HB370_RS33785	COG0183	Belongs to the thiolase family
HB370_RS33790	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS33905	COG1408	metallophosphoesterase
HB370_RS33930	COG1127	ABC transporter
HB370_RS33940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB370_RS33965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB370_RS34025	COG1132	(ABC) transporter
HB370_RS34070	COG0726	polysaccharide deacetylase
HB370_RS34085	COG1653	transport
HB370_RS34090	COG1175	transmembrane transport
HB370_RS34100	COG1472	Belongs to the glycosyl hydrolase 3 family
HB370_RS34120	COG0673	inositol 2-dehydrogenase activity
HB370_RS34125	COG0673	inositol 2-dehydrogenase activity
HB370_RS34140	COG0477	Major facilitator Superfamily
HB370_RS34180	COG0210	DNA helicase
HB370_RS34225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB370_RS34315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB370_RS34320	COG3275	phosphorelay sensor kinase activity
HB370_RS34325	COG0531	amino acid
HB370_RS34335	COG3938	Belongs to the proline racemase family
HB370_RS34340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB370_RS34345	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB370_RS34355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HB370_RS34370	COG0765	amino acid transport
HB370_RS34380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS34385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS34390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS34395	COG2175	clavaminate synthase activity
HB370_RS34450	COG2838	Isocitrate dehydrogenase
HB370_RS34460	COG0668	transmembrane transport
HB370_RS34465	COG0531	amino acid
HB370_RS34475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB370_RS34495	COG1132	(ABC) transporter
HB370_RS34500	COG2080	2 iron, 2 sulfur cluster binding
HB370_RS34505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HB370_RS34510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB370_RS34520	COG0456	acetyltransferase
HB370_RS34520	COG0454	-acetyltransferase
HB370_RS34535	COG0395	ABC-type sugar transport system, permease component
HB370_RS34570	COG1309	transcriptional regulator
HB370_RS34575	COG1278	Cold shock
HB370_RS34585	COG4977	sequence-specific DNA binding
HB370_RS34615	COG3591	Belongs to the peptidase S1B family
HB370_RS34615	COG1864	DNA RNA non-specific endonuclease
HB370_RS34625	COG1404	Belongs to the peptidase S8 family
HB370_RS34670	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HB370_RS34680	COG0583	DNA-binding transcription factor activity
HB370_RS34695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HB370_RS34715	COG3537	Alpha-1,2-mannosidase
HB370_RS34745	COG0154	amidase activity
HB370_RS34750	COG1609	Transcriptional regulator
HB370_RS34755	COG1653	transport
HB370_RS34760	COG1175	transmembrane transport
HB370_RS34765	COG0395	ABC-type sugar transport system, permease component
HB370_RS34795	COG0515	serine threonine protein kinase
HB370_RS34800	COG2186	Transcriptional regulator
HB370_RS34805	COG4948	Mandelate Racemase Muconate Lactonizing
HB370_RS34860	COG0531	amino acid
HB370_RS34905	COG0583	DNA-binding transcription factor activity
HB370_RS34915	COG0583	DNA-binding transcription factor activity
HB370_RS34925	COG1053	succinate dehydrogenase
HB370_RS34930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB370_RS34960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB370_RS34970	COG3360	Dodecin
HB370_RS34975	COG2182	Extracellular solute-binding protein
HB370_RS34980	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HB370_RS34985	COG0121	glutamine amidotransferase
HB370_RS34990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB370_RS35045	COG3842	ATPase activity
HB370_RS35050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HB370_RS35055	COG1176	ABC-type spermidine putrescine transport system, permease component I
HB370_RS35060	COG1177	transmembrane transport
HB370_RS35065	COG0456	acetyltransferase
HB370_RS35090	COG1132	(ABC) transporter
HB370_RS35100	COG0681	Belongs to the peptidase S26 family
HB370_RS35120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB370_RS35130	COG0242	peptide deformylase activity
HB370_RS35145	COG3336	cytochrome c oxidase
HB370_RS35160	COG1595	DNA-templated transcription, initiation
HB370_RS35165	COG2124	cytochrome p450
HB370_RS35170	COG0477	Major facilitator Superfamily
HB370_RS35175	COG1846	Transcriptional regulator
HB370_RS35220	COG0542	response to heat
HB370_RS35225	COG1174	glycine betaine transport
HB370_RS35245	COG1556	Lactate utilization protein
HB370_RS35250	COG1139	Iron-sulfur cluster binding protein
HB370_RS35255	COG0247	lactate metabolic process
HB370_RS35260	COG1070	Carbohydrate kinase
HB370_RS35265	COG3347	Dehydrogenase
HB370_RS35265	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS35270	COG4952	isomerase
HB370_RS35280	COG3254	rhamnose metabolic process
HB370_RS35290	COG1609	Transcriptional regulator
HB370_RS35300	COG0789	Transcriptional regulator
HB370_RS35310	COG1357	PFAM Pentapeptide repeats (8 copies)
HB370_RS35330	COG2706	6-phosphogluconolactonase activity
HB370_RS35350	COG2124	cytochrome p450
HB370_RS35350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB370_RS35355	COG1846	Transcriptional regulator
HB370_RS35355	COG1940	carbohydrate kinase activity
HB370_RS35380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HB370_RS35385	COG0443	Heat shock 70 kDa protein
HB370_RS35415	COG1136	(ABC) transporter
HB370_RS35415	COG0577	efflux transmembrane transporter activity
HB370_RS35460	COG0546	phosphoglycolate phosphatase activity
HB370_RS35465	COG1796	DNA polymerase
HB370_RS35465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HB370_RS35470	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS35510	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB370_RS35535	COG0435	Glutathione S-transferase
HB370_RS35550	COG2124	cytochrome p450
HB370_RS35565	COG0667	Aldo Keto reductase
HB370_RS35585	COG0515	serine threonine protein kinase
HB370_RS35585	COG2815	serine threonine protein kinase
HB370_RS35600	COG3250	beta-galactosidase activity
HB370_RS35625	COG2890	protein-(glutamine-N5) methyltransferase activity
HB370_RS35640	COG4221	oxidoreductase activity
HB370_RS35650	COG0726	polysaccharide deacetylase
HB370_RS35700	COG2124	cytochrome p450
HB370_RS35720	COG3251	PFAM MbtH domain protein
HB370_RS35765	COG0277	FAD linked oxidase domain protein
HB370_RS35765	COG0247	lactate metabolic process
HB370_RS35770	COG4948	Mandelate Racemase Muconate Lactonizing
HB370_RS35775	COG0300	oxidoreductase activity
HB370_RS35785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB370_RS35820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HB370_RS35820	COG3608	succinylglutamate desuccinylase aspartoacylase
HB370_RS35875	COG1657	PFAM Prenyltransferase squalene oxidase
HB370_RS35910	COG0076	glutamate decarboxylase activity
HB370_RS35960	COG1309	transcriptional regulator
HB370_RS35995	COG0572	uridine kinase
HB370_RS36025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HB370_RS36035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HB370_RS36045	COG3387	PFAM Glycoside hydrolase 15-related
HB370_RS36060	COG3290	protein histidine kinase activity
HB370_RS36100	COG0456	acetyltransferase
HB370_RS36165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB370_RS36195	COG0584	glycerophosphoryl diester phosphodiesterase
HB370_RS36230	COG0667	Aldo Keto reductase
HB370_RS36250	COG2124	cytochrome p450
HB370_RS36280	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HB370_RS36305	COG0248	Ppx GppA phosphatase
HB370_RS36310	COG0222	ribosome binding
HB370_RS36335	COG1982	Orn Lys Arg decarboxylase major
HB370_RS36360	COG2172	sigma factor antagonist activity
HB370_RS36365	COG1366	Belongs to the anti-sigma-factor antagonist family
HB370_RS36370	COG1366	Belongs to the anti-sigma-factor antagonist family
HB370_RS36380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB370_RS36405	COG4585	Histidine kinase
HB370_RS36410	COG2197	response regulator
HB370_RS36455	COG0531	amino acid
HB370_RS36485	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS36495	COG0395	ABC-type sugar transport system, permease component
HB370_RS36525	COG2755	lipolytic protein G-D-S-L family
HB370_RS36535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB370_RS36595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB370_RS36600	COG1733	regulation of RNA biosynthetic process
HB370_RS36610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HB370_RS36620	COG0488	(ABC) transporter
HB370_RS36625	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS36640	COG3340	Belongs to the peptidase S51 family
HB370_RS36655	COG0277	FAD linked oxidase domain protein
HB370_RS36660	COG1597	lipid kinase activity
HB370_RS36670	COG0542	response to heat
HB370_RS36680	COG1366	Belongs to the anti-sigma-factor antagonist family
HB370_RS36690	COG1316	TRANSCRIPTIONal
HB370_RS36710	COG2945	thiolester hydrolase activity
HB370_RS36710	COG0596	Alpha beta hydrolase
HB370_RS36720	COG2409	Drug exporters of the RND superfamily
HB370_RS36750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB370_RS36765	COG0736	holo-[acyl-carrier-protein] synthase activity
HB370_RS36770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB370_RS36775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HB370_RS36780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB370_RS36785	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HB370_RS36815	COG0736	holo-[acyl-carrier-protein] synthase activity
HB370_RS36820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HB370_RS36825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS36845	COG2814	Major facilitator Superfamily
HB370_RS36850	COG0367	asparagine synthase
HB370_RS36860	COG1595	DNA-templated transcription, initiation
HB370_RS36870	COG0515	serine threonine protein kinase
HB370_RS36870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB370_RS36900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB370_RS36950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB370_RS36955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS36970	COG1937	Protein conserved in bacteria
HB370_RS37015	COG0326	Molecular chaperone. Has ATPase activity
HB370_RS37040	COG0477	Major facilitator Superfamily
HB370_RS37075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB370_RS37095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB370_RS37115	COG2267	carboxylic ester hydrolase activity
HB370_RS37120	COG2207	Transcriptional regulator
HB370_RS37155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB370_RS37170	COG5640	endopeptidase activity
HB370_RS37175	COG0583	DNA-binding transcription factor activity
HB370_RS37185	COG0640	Transcriptional regulator
HB370_RS37195	COG1733	regulation of RNA biosynthetic process
HB370_RS37215	COG2226	methyltransferase
HB370_RS37275	COG1857	crispr-associated protein
HB370_RS37290	COG1518	maintenance of DNA repeat elements
HB370_RS37295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB370_RS37350	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HB370_RS37500	COG4566	intracellular signal transduction
HB370_RS37515	COG0783	Belongs to the Dps family
HB370_RS37520	COG2259	Doxx family
HB370_RS37525	COG1335	isochorismatase
HB370_RS37530	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HB370_RS37570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS37600	COG3293	Transposase
HB370_RS37615	COG0395	ABC-type sugar transport system, permease component
HB370_RS37630	COG0366	Alpha amylase catalytic
HB370_RS37635	COG1846	Transcriptional regulator
HB370_RS37635	COG1940	carbohydrate kinase activity
HB370_RS37670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB370_RS38000	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB370_RS38075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB370_RS38090	COG1024	Enoyl-CoA hydratase
HB370_RS38105	COG1793	dna ligase
HB370_RS38135	COG1484	DNA-dependent DNA replication
HB370_RS38185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HB370_RS38185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB370_RS38190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB370_RS38195	COG1022	Amp-dependent synthetase and ligase
HB370_RS38200	COG1511	domain protein
HB370_RS38340	COG0583	DNA-binding transcription factor activity
HB370_RS38380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB370_RS38385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB370_RS38405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB370_RS38450	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HB370_RS38455	COG0714	Associated with various cellular activities
HB370_RS38465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB370_RS38480	COG3328	transposase activity
HB370_RS38490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB370_RS38500	COG2816	NAD+ diphosphatase activity
HB370_RS38550	COG2211	Major facilitator Superfamily
HB370_RS38630	COG3387	PFAM Glycoside hydrolase 15-related
HB370_RS38760	COG0252	asparaginase activity
HB370_RS38785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB370_RS38830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB370_RS38930	COG4974	Belongs to the 'phage' integrase family
HB370_RS38965	COG4166	transmembrane transport
HB370_RS38980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB370_RS38990	COG2175	clavaminate synthase activity
HB370_RS39000	COG4521	taurine ABC transporter
HB370_RS39005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB370_RS39015	COG1063	alcohol dehydrogenase
HB370_RS39035	COG0590	tRNA wobble adenosine to inosine editing
HB370_RS39115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB370_RS39160	COG1216	Glycosyl transferase, family 2
HB370_RS39165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB370_RS39175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HB370_RS39195	COG5285	phytanoyl-CoA dioxygenase
HB370_RS39200	COG1917	Cupin 2, conserved barrel domain protein
HB370_RS39210	COG0475	glutathione-regulated potassium exporter activity
HB370_RS39220	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS39235	COG0493	'glutamate synthase
HB370_RS39245	COG0456	acetyltransferase
HB370_RS39280	COG1595	DNA-templated transcription, initiation
HB370_RS39330	COG4989	oxidoreductase activity
HB370_RS39350	COG0662	Cupin 2, conserved barrel domain protein
HB370_RS39355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HB370_RS39370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB370_RS39375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HB370_RS39400	COG1131	(ABC) transporter
HB370_RS39405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB370_RS39450	COG3833	ABC-type maltose transport systems, permease component
HB370_RS39455	COG0366	Alpha amylase catalytic
HB370_RS39460	COG1609	Transcriptional regulator
HB370_RS39475	COG1012	belongs to the aldehyde dehydrogenase family
HB370_RS39485	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB370_RS39485	COG1902	pentaerythritol trinitrate reductase activity
HB370_RS39500	COG1131	(ABC) transporter
HB370_RS39550	COG3708	Transcriptional regulator
HB370_RS39550	COG2207	Transcriptional regulator
HB370_RS39610	COG2080	2 iron, 2 sulfur cluster binding
HB370_RS39615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HB370_RS39620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB370_RS39625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HB370_RS39690	COG0477	Major facilitator Superfamily
HB370_RS39705	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS39730	COG3345	alpha-galactosidase
HB370_RS39735	COG3507	Belongs to the glycosyl hydrolase 43 family
HB370_RS39830	COG0714	Associated with various cellular activities
HB370_RS39845	COG0488	(ABC) transporter
HB370_RS39850	COG0488	(ABC) transporter
HB370_RS39870	COG2124	cytochrome p450
HB370_RS39890	COG1073	alpha beta
HB370_RS39895	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS39900	COG1309	transcriptional regulator
HB370_RS39925	COG1595	DNA-templated transcription, initiation
HB370_RS39935	COG1764	response to oxidative stress
HB370_RS40000	COG0475	glutathione-regulated potassium exporter activity
HB370_RS40015	COG0492	ferredoxin-NADP+ reductase activity
HB370_RS40020	COG0318	PFAM AMP-dependent synthetase and ligase
HB370_RS40100	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB370_RS40110	COG0583	DNA-binding transcription factor activity
HB370_RS40125	COG0431	NADPH-dependent FMN reductase
HB370_RS40160	COG1846	Transcriptional regulator
HB370_RS40175	COG0300	oxidoreductase activity
HB370_RS40215	COG1309	transcriptional regulator
HB370_RS40220	COG1028	Short-chain dehydrogenase reductase Sdr
HB370_RS40230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB370_RS40325	COG0515	serine threonine protein kinase
HB370_RS40325	COG3266	domain, Protein
HB370_RS40350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB370_RS40375	COG2175	clavaminate synthase activity
HB370_RS40385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB370_RS40390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB370_RS40405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HB370_RS40420	COG2197	response regulator
HB370_RS40470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB370_RS40490	COG2226	methyltransferase
HB370_RS40510	COG0726	polysaccharide deacetylase
HB370_RS40520	COG0726	polysaccharide deacetylase
HB370_RS40530	COG1960	acyl-CoA dehydrogenase activity
HB370_RS40535	COG0235	Class ii aldolase
HB370_RS40565	COG0583	DNA-binding transcription factor activity
HB370_RS40635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB370_RS40635	COG2070	2-Nitropropane dioxygenase
HB370_RS40645	COG0534	Mate efflux family protein
HB370_RS40660	COG0596	Alpha beta hydrolase
HB370_RS40695	COG2815	serine threonine protein kinase
HB370_RS40695	COG0515	serine threonine protein kinase
HB370_RS40700	COG1674	ftsk spoiiie
HB370_RS40715	COG2046	Belongs to the sulfate adenylyltransferase family
HB370_RS40715	COG0529	Catalyzes the synthesis of activated sulfate
HB370_RS40720	COG2326	polyphosphate kinase activity
HB370_RS40730	COG1733	regulation of RNA biosynthetic process
HB370_RS40760	COG2755	lipolytic protein G-D-S-L family
HB370_RS40870	COG5297	Belongs to the glycosyl hydrolase family 6
HB370_RS40870	COG4733	cellulase activity
HB370_RS40880	COG1215	transferase activity, transferring glycosyl groups
HB370_RS40895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB370_RS40910	COG1091	dTDP-4-dehydrorhamnose reductase activity
HB370_RS40940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB370_RS40955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB370_RS40970	COG1132	(ABC) transporter
HB370_RS41000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB370_RS41015	COG1834	amidinotransferase
HB370_RS41195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase