locus-tag	class	description
CYL76_RS00110	COG3883	PFAM NLP P60 protein
CYL76_RS00110	COG0791	NLP P60 protein
CYL76_RS00115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CYL76_RS00310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYL76_RS00390	COG2826	transposase and inactivated derivatives, IS30 family
CYL76_RS00410	COG1595	DNA-templated transcription, initiation
CYL76_RS00440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYL76_RS00500	COG0640	Transcriptional regulator
CYL76_RS00675	COG2801	Transposase and inactivated derivatives
CYL76_RS00715	COG1191	sigma factor activity
CYL76_RS00795	COG2124	cytochrome p450
CYL76_RS00825	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CYL76_RS00850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYL76_RS01075	COG2045	Belongs to the ComB family
CYL76_RS01110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYL76_RS01115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYL76_RS01270	COG1846	Transcriptional regulator
CYL76_RS01275	COG1764	response to oxidative stress
CYL76_RS01285	COG0789	Transcriptional regulator
CYL76_RS01320	COG1902	pentaerythritol trinitrate reductase activity
CYL76_RS01345	COG0702	epimerase
CYL76_RS01400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYL76_RS01415	COG1175	transmembrane transport
CYL76_RS01420	COG1653	transport
CYL76_RS01460	COG1349	DNA-binding transcription factor activity
CYL76_RS01465	COG1105	Belongs to the carbohydrate kinase PfkB family
CYL76_RS01535	COG0254	rRNA binding
CYL76_RS01595	COG1024	Enoyl-CoA hydratase
CYL76_RS01645	COG1653	transport
CYL76_RS01685	COG1349	DNA-binding transcription factor activity
CYL76_RS01760	COG0254	rRNA binding
CYL76_RS01820	COG1024	Enoyl-CoA hydratase
CYL76_RS01855	COG0765	amino acid transport
CYL76_RS01870	COG2366	antibiotic biosynthetic process
CYL76_RS01880	COG2070	2-Nitropropane dioxygenase
CYL76_RS01915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYL76_RS01920	COG0346	lactoylglutathione lyase activity
CYL76_RS01935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYL76_RS01955	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS01960	COG2813	Specifically methylates the guanine in position
CYL76_RS01975	COG2356	endonuclease I
CYL76_RS01995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYL76_RS02020	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CYL76_RS02025	COG2080	2 iron, 2 sulfur cluster binding
CYL76_RS02105	COG1120	ATPase activity
CYL76_RS02110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYL76_RS02130	COG0477	Major facilitator Superfamily
CYL76_RS02135	COG2382	esterase
CYL76_RS02155	COG1021	2,3-dihydroxybenzoate-AMP ligase
CYL76_RS02165	COG1535	isochorismatase
CYL76_RS02165	COG3433	isochorismatase activity
CYL76_RS02220	COG3845	ABC transporter
CYL76_RS02245	COG1470	cell adhesion involved in biofilm formation
CYL76_RS02275	COG1063	alcohol dehydrogenase
CYL76_RS02280	COG0395	ABC-type sugar transport system, permease component
CYL76_RS02360	COG1132	(ABC) transporter
CYL76_RS02365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CYL76_RS02370	COG1120	ATPase activity
CYL76_RS02375	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS02385	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CYL76_RS02400	COG1840	ABC-type Fe3 transport system, periplasmic component
CYL76_RS02440	COG0640	Transcriptional regulator
CYL76_RS02460	COG2072	flavoprotein involved in K transport
CYL76_RS02465	COG0798	PFAM Bile acid sodium symporter
CYL76_RS02475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYL76_RS02480	COG0492	ferredoxin-NADP+ reductase activity
CYL76_RS02490	COG0789	Transcriptional regulator
CYL76_RS02510	COG1461	Dihydroxyacetone kinase
CYL76_RS02555	COG1191	sigma factor activity
CYL76_RS02585	COG1120	ATPase activity
CYL76_RS02590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS02615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYL76_RS02665	COG1295	ribonuclease BN
CYL76_RS02665	COG1959	2 iron, 2 sulfur cluster binding
CYL76_RS02810	COG2264	protein methyltransferase activity
CYL76_RS02855	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYL76_RS02915	COG2205	protein histidine kinase activity
CYL76_RS02945	COG0464	growth
CYL76_RS02960	COG1349	DNA-binding transcription factor activity
CYL76_RS03015	COG1940	carbohydrate kinase activity
CYL76_RS03060	COG0445	tRNA wobble uridine modification
CYL76_RS03105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CYL76_RS03150	COG0584	glycerophosphoryl diester phosphodiesterase
CYL76_RS03160	COG0456	acetyltransferase
CYL76_RS03230	COG2971	BadF BadG BcrA BcrD
CYL76_RS03240	COG2706	6-phosphogluconolactonase activity
CYL76_RS03260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYL76_RS03270	COG0667	Aldo Keto reductase
CYL76_RS03300	COG1253	flavin adenine dinucleotide binding
CYL76_RS03350	COG2186	Transcriptional regulator
CYL76_RS03355	COG0174	glutamine synthetase
CYL76_RS03360	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS03475	COG1357	PFAM Pentapeptide repeats (8 copies)
CYL76_RS03575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS03585	COG4592	Periplasmic binding protein
CYL76_RS03615	COG0385	Bile acid
CYL76_RS03640	COG0583	DNA-binding transcription factor activity
CYL76_RS03660	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CYL76_RS03690	COG2801	Transposase and inactivated derivatives
CYL76_RS03720	COG0589	response to stress
CYL76_RS03735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYL76_RS03735	COG4651	solute:proton antiporter activity
CYL76_RS03745	COG0589	response to stress
CYL76_RS03800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CYL76_RS03810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYL76_RS03810	COG1017	nitric oxide dioxygenase activity
CYL76_RS03825	COG0517	IMP dehydrogenase activity
CYL76_RS03825	COG0516	GMP reductase activity
CYL76_RS03830	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS03830	COG1454	alcohol dehydrogenase
CYL76_RS03855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYL76_RS03890	COG1120	ATPase activity
CYL76_RS03915	COG2072	flavoprotein involved in K transport
CYL76_RS03950	COG1132	(ABC) transporter
CYL76_RS03955	COG1132	(ABC) transporter
CYL76_RS03980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYL76_RS03980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYL76_RS04000	COG1793	dna ligase
CYL76_RS04015	COG1946	Acyl-CoA thioesterase
CYL76_RS04035	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS04045	COG0242	peptide deformylase activity
CYL76_RS04055	COG3442	glutamine amidotransferase
CYL76_RS04060	COG0205	6-phosphofructokinase activity
CYL76_RS04070	COG0204	Acyl-transferase
CYL76_RS04085	COG0829	nickel cation binding
CYL76_RS04105	COG0832	Belongs to the urease beta subunit family
CYL76_RS04110	COG0831	urea catabolic process
CYL76_RS04155	COG0156	8-amino-7-oxononanoate synthase activity
CYL76_RS04160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYL76_RS04165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYL76_RS04175	COG2226	methyltransferase
CYL76_RS04200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYL76_RS04205	COG3663	DNA glycosylase
CYL76_RS04215	COG1940	carbohydrate kinase activity
CYL76_RS04225	COG1595	DNA-templated transcription, initiation
CYL76_RS04255	COG0626	cystathionine gamma-synthase activity
CYL76_RS04275	COG1522	sequence-specific DNA binding
CYL76_RS04280	COG0419	ATPase involved in DNA repair
CYL76_RS04285	COG0420	3'-5' exonuclease activity
CYL76_RS04290	COG1739	Uncharacterized protein family UPF0029
CYL76_RS04295	COG1832	CoA-binding protein
CYL76_RS04350	COG1968	undecaprenyl-diphosphatase activity
CYL76_RS04365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYL76_RS04415	COG2318	DinB family
CYL76_RS04430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CYL76_RS04545	COG2208	phosphoserine phosphatase activity
CYL76_RS04650	COG3629	intracellular signal transduction
CYL76_RS04650	COG3903	Transcriptional regulator
CYL76_RS04690	COG0657	acetylesterase activity
CYL76_RS04695	COG0242	peptide deformylase activity
CYL76_RS04710	COG0431	NADPH-dependent FMN reductase
CYL76_RS04715	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS04795	COG0583	DNA-binding transcription factor activity
CYL76_RS04865	COG1695	Transcriptional regulator
CYL76_RS04910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYL76_RS04910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYL76_RS05000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYL76_RS05045	COG2018	Roadblock/LC7 domain
CYL76_RS05120	COG2364	Membrane
CYL76_RS05130	COG2270	Major facilitator Superfamily
CYL76_RS05140	COG3030	protein affecting phage T7 exclusion by the F plasmid
CYL76_RS05145	COG1216	Glycosyl transferase, family 2
CYL76_RS05170	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS05215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYL76_RS05220	COG0140	phosphoribosyl-ATP diphosphatase activity
CYL76_RS05225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CYL76_RS05235	COG3201	nicotinamide mononucleotide transporter
CYL76_RS05260	COG0738	Major facilitator superfamily
CYL76_RS05280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYL76_RS05290	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS05305	COG2390	Transcriptional regulator
CYL76_RS05310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYL76_RS05320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYL76_RS05335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYL76_RS05345	COG1758	RNA polymerase activity
CYL76_RS05360	COG0284	orotidine-5'-phosphate decarboxylase activity
CYL76_RS05365	COG0167	dihydroorotate dehydrogenase activity
CYL76_RS05375	COG0505	Belongs to the CarA family
CYL76_RS05385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYL76_RS05390	COG0540	Belongs to the ATCase OTCase family
CYL76_RS05395	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYL76_RS05405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYL76_RS05410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYL76_RS05415	COG0006	proline dipeptidase activity
CYL76_RS05425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYL76_RS05430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYL76_RS05435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYL76_RS05455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYL76_RS05460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYL76_RS05480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYL76_RS05500	COG0124	histidyl-tRNA synthetase
CYL76_RS05515	COG1196	nuclear chromosome segregation
CYL76_RS05525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CYL76_RS05530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYL76_RS05535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYL76_RS05545	COG2255	four-way junction helicase activity
CYL76_RS05550	COG0632	four-way junction helicase activity
CYL76_RS05555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYL76_RS05560	COG0217	transcriptional regulatory protein
CYL76_RS05565	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CYL76_RS05570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CYL76_RS05580	COG0438	transferase activity, transferring glycosyl groups
CYL76_RS05590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYL76_RS05615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYL76_RS05630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CYL76_RS05685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYL76_RS05760	COG1464	Belongs to the NlpA lipoprotein family
CYL76_RS05765	COG2011	ABC-type metal ion transport system permease component
CYL76_RS05805	COG0477	Major facilitator Superfamily
CYL76_RS05820	COG3973	AAA domain
CYL76_RS05830	COG0165	Argininosuccinate lyase
CYL76_RS05835	COG0137	argininosuccinate synthase activity
CYL76_RS05845	COG1438	arginine binding
CYL76_RS05850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYL76_RS05855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYL76_RS05860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYL76_RS05865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYL76_RS05910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CYL76_RS05925	COG0697	spore germination
CYL76_RS05935	COG1649	PFAM Uncharacterised BCR, COG1649
CYL76_RS05955	COG0072	phenylalanine-tRNA ligase activity
CYL76_RS05955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYL76_RS05960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYL76_RS05975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYL76_RS05980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYL76_RS05985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYL76_RS06055	COG0517	IMP dehydrogenase activity
CYL76_RS06055	COG4175	Glycine betaine
CYL76_RS06060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYL76_RS06085	COG1595	DNA-templated transcription, initiation
CYL76_RS06150	COG0805	protein transport
CYL76_RS06155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYL76_RS06175	COG2378	regulation of single-species biofilm formation
CYL76_RS06185	COG0545	Peptidyl-prolyl cis-trans isomerase
CYL76_RS06190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CYL76_RS06200	COG1609	Transcriptional regulator
CYL76_RS06210	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CYL76_RS06225	COG4122	O-methyltransferase activity
CYL76_RS06230	COG1222	aaa ATPase
CYL76_RS06265	COG2197	response regulator
CYL76_RS06270	COG4166	transmembrane transport
CYL76_RS06280	COG0646	methionine synthase
CYL76_RS06280	COG1410	methionine synthase
CYL76_RS06285	COG1414	Transcriptional regulator
CYL76_RS06290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CYL76_RS06295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CYL76_RS06300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CYL76_RS06315	COG0215	cysteine-tRNA ligase activity
CYL76_RS06345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL76_RS06350	COG0667	Aldo Keto reductase
CYL76_RS06395	COG0564	pseudouridine synthase activity
CYL76_RS06400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYL76_RS06410	COG2186	Transcriptional regulator
CYL76_RS06445	COG3573	Dehydrogenase
CYL76_RS06450	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CYL76_RS06455	COG2149	membrane
CYL76_RS06475	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS06480	COG4935	Belongs to the peptidase S8 family
CYL76_RS06480	COG2234	aminopeptidase activity
CYL76_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS06500	COG3876	Protein conserved in bacteria
CYL76_RS06520	COG0789	Transcriptional regulator
CYL76_RS06605	COG2326	polyphosphate kinase activity
CYL76_RS06630	COG2851	Citrate transporter
CYL76_RS06635	COG0243	molybdopterin cofactor binding
CYL76_RS06640	COG1309	transcriptional regulator
CYL76_RS06650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CYL76_RS06655	COG2188	Transcriptional regulator
CYL76_RS06720	COG4565	transcriptional regulatory protein
CYL76_RS06750	COG0587	DNA-directed DNA polymerase activity
CYL76_RS06820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL76_RS06830	COG1799	cell septum assembly
CYL76_RS06845	COG0671	phosphoesterase, PA-phosphatase related
CYL76_RS06865	COG0438	transferase activity, transferring glycosyl groups
CYL76_RS06880	COG1160	GTP binding
CYL76_RS06890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYL76_RS06925	COG3541	Predicted nucleotidyltransferase
CYL76_RS06935	COG0494	nUDIX hydrolase
CYL76_RS06950	COG1187	pseudouridine synthase activity
CYL76_RS06955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CYL76_RS06960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CYL76_RS06975	COG0686	Belongs to the AlaDH PNT family
CYL76_RS06985	COG0494	nUDIX hydrolase
CYL76_RS06990	COG0504	CTP synthase activity
CYL76_RS07020	COG0297	glycogen (starch) synthase activity
CYL76_RS07095	COG2094	Belongs to the DNA glycosylase MPG family
CYL76_RS07105	COG1881	PFAM PEBP family protein
CYL76_RS07130	COG1119	ATPase activity
CYL76_RS07160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYL76_RS07170	COG0842	Transport permease protein
CYL76_RS07170	COG1131	(ABC) transporter
CYL76_RS07170	COG1716	ATPase activity
CYL76_RS07175	COG3830	Belongs to the UPF0237 family
CYL76_RS07175	COG0560	Phosphoserine phosphatase
CYL76_RS07195	COG2186	Transcriptional regulator
CYL76_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS07225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYL76_RS07245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYL76_RS07250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYL76_RS07300	COG3387	PFAM Glycoside hydrolase 15-related
CYL76_RS07340	COG1024	Enoyl-CoA hydratase
CYL76_RS07350	COG0488	(ABC) transporter
CYL76_RS07375	COG0235	Class ii aldolase
CYL76_RS07390	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CYL76_RS07410	COG1797	cobyrinic acid a,c-diamide synthase activity
CYL76_RS07465	COG1902	pentaerythritol trinitrate reductase activity
CYL76_RS07470	COG1846	Transcriptional regulator
CYL76_RS07490	COG2205	protein histidine kinase activity
CYL76_RS07495	COG0745	RESPONSE REGULATOR receiver
CYL76_RS07505	COG1929	Belongs to the glycerate kinase type-1 family
CYL76_RS07520	COG4977	sequence-specific DNA binding
CYL76_RS07535	COG3634	alkyl hydroperoxide reductase activity
CYL76_RS07555	COG0768	penicillin binding
CYL76_RS07605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYL76_RS07610	COG2171	N-acyltransferase activity
CYL76_RS07625	COG3226	Transcriptional regulator
CYL76_RS07645	COG2151	metal-sulfur cluster biosynthetic enzyme
CYL76_RS07650	COG0822	iron-sulfur transferase activity
CYL76_RS07655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYL76_RS07660	COG0396	ATPase activity
CYL76_RS07670	COG0719	Fe-S assembly protein
CYL76_RS07685	COG1131	(ABC) transporter
CYL76_RS07695	COG1612	heme a metabolic process
CYL76_RS07715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYL76_RS07730	COG0363	glucosamine-6-phosphate deaminase activity
CYL76_RS07740	COG4195	phage-related replication protein
CYL76_RS07755	COG0166	Belongs to the GPI family
CYL76_RS07765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYL76_RS07775	COG0126	phosphoglycerate kinase activity
CYL76_RS07780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYL76_RS07785	COG1481	regulation of sporulation
CYL76_RS07790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYL76_RS07795	COG1660	Displays ATPase and GTPase activities
CYL76_RS07800	COG0322	excinuclease ABC activity
CYL76_RS07825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYL76_RS07865	COG0556	nucleotide-excision repair
CYL76_RS07885	COG2814	Major facilitator Superfamily
CYL76_RS07895	COG2313	pseudouridylate synthase activity
CYL76_RS07960	COG0237	dephospho-CoA kinase activity
CYL76_RS08020	COG2050	protein possibly involved in aromatic compounds catabolism
CYL76_RS08105	COG2824	Alkylphosphonate utilization operon protein PhnA
CYL76_RS08125	COG1605	Chorismate mutase
CYL76_RS08125	COG0287	Prephenate dehydrogenase
CYL76_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS08170	COG1024	Enoyl-CoA hydratase
CYL76_RS08195	COG1278	Cold shock
CYL76_RS08200	COG0183	Belongs to the thiolase family
CYL76_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS08240	COG0705	Rhomboid family
CYL76_RS08250	COG0070	glutamate synthase
CYL76_RS08250	COG0069	glutamate synthase activity
CYL76_RS08250	COG0067	glutamate synthase
CYL76_RS08280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYL76_RS08285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CYL76_RS08295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYL76_RS08305	COG0159	tryptophan synthase activity
CYL76_RS08310	COG0133	tryptophan synthase activity
CYL76_RS08320	COG0134	indole-3-glycerol-phosphate synthase activity
CYL76_RS08340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYL76_RS08345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYL76_RS08355	COG2508	Transcriptional regulator
CYL76_RS08370	COG0107	imidazoleglycerol-phosphate synthase activity
CYL76_RS08375	COG0251	oxidation-reduction process
CYL76_RS08380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYL76_RS08385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYL76_RS08390	COG0131	Imidazoleglycerol-phosphate dehydratase
CYL76_RS08395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYL76_RS08400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYL76_RS08415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYL76_RS08440	COG1432	Conserved Protein
CYL76_RS08450	COG0587	DNA-directed DNA polymerase activity
CYL76_RS08500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYL76_RS08510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYL76_RS08515	COG3599	regulation of cell shape
CYL76_RS08525	COG1799	cell septum assembly
CYL76_RS08530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYL76_RS08555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYL76_RS08565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYL76_RS08570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYL76_RS08585	COG0768	penicillin binding
CYL76_RS08595	COG0275	rRNA processing
CYL76_RS08605	COG0714	Associated with various cellular activities
CYL76_RS08625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYL76_RS08635	COG1131	(ABC) transporter
CYL76_RS08640	COG1511	domain protein
CYL76_RS08675	COG0352	thiamine-phosphate diphosphorylase activity
CYL76_RS08705	COG2022	thiamine diphosphate biosynthetic process
CYL76_RS08715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CYL76_RS08720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYL76_RS08725	COG2193	ferroxidase activity
CYL76_RS08735	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CYL76_RS08750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYL76_RS08755	COG2197	response regulator
CYL76_RS08785	COG1940	carbohydrate kinase activity
CYL76_RS08860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYL76_RS08865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYL76_RS08870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYL76_RS08875	COG0723	plastoquinol--plastocyanin reductase activity
CYL76_RS08880	COG2010	Cytochrome c
CYL76_RS08885	COG1845	cytochrome c oxidase, subunit III
CYL76_RS08895	COG1376	ErfK ybiS ycfS ynhG family protein
CYL76_RS08905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYL76_RS08915	COG1104	cysteine desulfurase activity
CYL76_RS08920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYL76_RS08940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CYL76_RS08950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYL76_RS08960	COG4585	Histidine kinase
CYL76_RS09000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CYL76_RS09005	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CYL76_RS09005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYL76_RS09020	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CYL76_RS09025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYL76_RS09030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYL76_RS09035	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYL76_RS09045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CYL76_RS09080	COG0321	lipoyl(octanoyl) transferase activity
CYL76_RS09165	COG0745	RESPONSE REGULATOR receiver
CYL76_RS09240	COG3833	ABC-type maltose transport systems, permease component
CYL76_RS09245	COG1175	transmembrane transport
CYL76_RS09255	COG1609	Transcriptional regulator
CYL76_RS09300	COG2890	protein-(glutamine-N5) methyltransferase activity
CYL76_RS09380	COG0488	(ABC) transporter
CYL76_RS09385	COG0477	Major facilitator Superfamily
CYL76_RS09405	COG2801	Transposase and inactivated derivatives
CYL76_RS09405	COG3415	Transposase
CYL76_RS09410	COG0174	glutamine synthetase
CYL76_RS09425	COG2132	Multicopper oxidase
CYL76_RS09430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYL76_RS09430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYL76_RS09450	COG0477	Major facilitator Superfamily
CYL76_RS09475	COG1994	Peptidase M50
CYL76_RS09510	COG5398	heme oxygenase
CYL76_RS09530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYL76_RS09535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS09540	COG1120	ATPase activity
CYL76_RS09560	COG1834	amidinotransferase
CYL76_RS09580	COG2814	Major facilitator Superfamily
CYL76_RS09590	COG3540	Alkaline phosphatase
CYL76_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS09605	COG0384	phenazine biosynthesis protein PhzF
CYL76_RS09655	COG3022	response to hydroperoxide
CYL76_RS09660	COG0800	Aldolase
CYL76_RS09715	COG0183	Belongs to the thiolase family
CYL76_RS09740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYL76_RS09755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CYL76_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS09780	COG0655	NAD(P)H dehydrogenase (quinone) activity
CYL76_RS09815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL76_RS09850	COG0438	transferase activity, transferring glycosyl groups
CYL76_RS09855	COG1309	transcriptional regulator
CYL76_RS09925	COG3845	ABC transporter
CYL76_RS09935	COG0183	Belongs to the thiolase family
CYL76_RS09940	COG2124	cytochrome p450
CYL76_RS09995	COG2259	Doxx family
CYL76_RS10030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CYL76_RS10050	COG0494	nUDIX hydrolase
CYL76_RS10130	COG0582	viral genome integration into host DNA
CYL76_RS10220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CYL76_RS10230	COG0477	Major facilitator Superfamily
CYL76_RS10235	COG1309	transcriptional regulator
CYL76_RS10250	COG4585	Histidine kinase
CYL76_RS10255	COG2197	response regulator
CYL76_RS10270	COG0667	Aldo Keto reductase
CYL76_RS10275	COG0789	Transcriptional regulator
CYL76_RS10320	COG1741	Belongs to the pirin family
CYL76_RS10340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL76_RS10345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYL76_RS10375	COG1309	transcriptional regulator
CYL76_RS10385	COG1764	response to oxidative stress
CYL76_RS10390	COG2130	NADP-dependent
CYL76_RS10420	COG1522	sequence-specific DNA binding
CYL76_RS10440	COG0318	PFAM AMP-dependent synthetase and ligase
CYL76_RS10445	COG0825	malonyl-CoA metabolic process
CYL76_RS10445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYL76_RS10495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYL76_RS10510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYL76_RS10555	COG1942	4-Oxalocrotonate Tautomerase
CYL76_RS10565	COG1914	H( )-stimulated, divalent metal cation uptake system
CYL76_RS10570	COG0438	transferase activity, transferring glycosyl groups
CYL76_RS10580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CYL76_RS10590	COG0733	neurotransmitter:sodium symporter activity
CYL76_RS10630	COG1070	Carbohydrate kinase
CYL76_RS10645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYL76_RS10655	COG2226	methyltransferase
CYL76_RS10675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CYL76_RS10730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYL76_RS10730	COG2146	nitrite reductase [NAD(P)H] activity
CYL76_RS10755	COG0574	Belongs to the PEP-utilizing enzyme family
CYL76_RS10755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYL76_RS10765	COG3842	ATPase activity
CYL76_RS10770	COG2011	ABC-type metal ion transport system permease component
CYL76_RS10785	COG2188	Transcriptional regulator
CYL76_RS10835	COG2066	Belongs to the glutaminase family
CYL76_RS10885	COG0702	epimerase
CYL76_RS10900	COG2197	response regulator
CYL76_RS10930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYL76_RS10960	COG0423	glycine-tRNA ligase activity
CYL76_RS10965	COG3443	Belongs to the bacterial solute-binding protein 9 family
CYL76_RS10965	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYL76_RS10970	COG1121	(ABC) transporter
CYL76_RS10975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYL76_RS10985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYL76_RS11000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYL76_RS11030	COG2315	Protein conserved in bacteria
CYL76_RS11040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYL76_RS11060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CYL76_RS11065	COG1234	tRNA 3'-trailer cleavage
CYL76_RS11070	COG0537	adenosine 5'-monophosphoramidase activity
CYL76_RS11085	COG0484	heat shock protein binding
CYL76_RS11090	COG1420	regulation of RNA biosynthetic process
CYL76_RS11115	COG1022	Amp-dependent synthetase and ligase
CYL76_RS11120	COG0481	GTPase activity
CYL76_RS11125	COG0268	Binds directly to 16S ribosomal RNA
CYL76_RS11140	COG2353	YceI-like domain
CYL76_RS11155	COG1555	photosystem II stabilization
CYL76_RS11160	COG1307	EDD domain protein, DegV family
CYL76_RS11170	COG0495	leucyl-tRNA aminoacylation
CYL76_RS11205	COG0588	phosphoglycerate mutase activity
CYL76_RS11210	COG0799	negative regulation of ribosome biogenesis
CYL76_RS11220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYL76_RS11225	COG0501	Belongs to the peptidase M48B family
CYL76_RS11240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYL76_RS11275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYL76_RS11280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYL76_RS11285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYL76_RS11355	COG0772	Belongs to the SEDS family
CYL76_RS11360	COG0768	penicillin binding
CYL76_RS11375	COG1077	Cell shape determining protein MreB Mrl
CYL76_RS11380	COG0105	UTP biosynthetic process
CYL76_RS11395	COG0525	valine-tRNA ligase activity
CYL76_RS11405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYL76_RS11410	COG0740	serine-type endopeptidase activity
CYL76_RS11415	COG0740	serine-type endopeptidase activity
CYL76_RS11420	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYL76_RS11440	COG3594	Acyltransferase
CYL76_RS11445	COG0475	glutathione-regulated potassium exporter activity
CYL76_RS11455	COG4552	Acetyltransferase involved in intracellular survival and related
CYL76_RS11470	COG1113	amino acid transport
CYL76_RS11475	COG1268	BioY protein
CYL76_RS11480	COG1113	amino acid transport
CYL76_RS11485	COG1113	amino acid transport
CYL76_RS11495	COG0783	Belongs to the Dps family
CYL76_RS11505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYL76_RS11510	COG0640	Transcriptional regulator
CYL76_RS11525	COG0110	maltose O-acetyltransferase activity
CYL76_RS11545	COG3655	Transcriptional regulator
CYL76_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS11570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CYL76_RS11595	COG2337	Toxic component of a toxin-antitoxin (TA) module
CYL76_RS11620	COG4266	Belongs to the allantoicase family
CYL76_RS11655	COG0668	transmembrane transport
CYL76_RS11670	COG1175	transmembrane transport
CYL76_RS11675	COG0395	ABC-type sugar transport system, permease component
CYL76_RS11680	COG1486	melibiose metabolic process
CYL76_RS11695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL76_RS11730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYL76_RS11735	COG2346	COG2346, Truncated hemoglobins
CYL76_RS11760	COG0629	single-stranded DNA binding
CYL76_RS11780	COG4974	Belongs to the 'phage' integrase family
CYL76_RS12100	COG4585	Histidine kinase
CYL76_RS12125	COG1131	(ABC) transporter
CYL76_RS12145	COG3962	Belongs to the TPP enzyme family
CYL76_RS12150	COG3718	enzyme involved in inositol metabolism
CYL76_RS12170	COG2318	DinB family
CYL76_RS12180	COG3615	Tellurite resistance protein tehB
CYL76_RS12180	COG0500	methyltransferase
CYL76_RS12185	COG2409	Drug exporters of the RND superfamily
CYL76_RS12210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CYL76_RS12260	COG2409	Drug exporters of the RND superfamily
CYL76_RS12285	COG0673	inositol 2-dehydrogenase activity
CYL76_RS12345	COG1404	Belongs to the peptidase S8 family
CYL76_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS12395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYL76_RS12400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL76_RS12405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYL76_RS12410	COG1472	Belongs to the glycosyl hydrolase 3 family
CYL76_RS12440	COG3960	tartronate-semialdehyde synthase activity
CYL76_RS12510	COG1946	Acyl-CoA thioesterase
CYL76_RS12550	COG1309	transcriptional regulator
CYL76_RS12570	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS12580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CYL76_RS12610	COG0076	glutamate decarboxylase activity
CYL76_RS12615	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CYL76_RS12640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYL76_RS12645	COG0589	response to stress
CYL76_RS12650	COG4977	sequence-specific DNA binding
CYL76_RS12685	COG0395	ABC-type sugar transport system, permease component
CYL76_RS12700	COG2985	domain, Protein
CYL76_RS12815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL76_RS12820	COG0765	amino acid transport
CYL76_RS12825	COG0765	amino acid transport
CYL76_RS12830	COG1126	abc transporter atp-binding protein
CYL76_RS12845	COG3397	chitin binding
CYL76_RS12915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYL76_RS12955	COG0673	inositol 2-dehydrogenase activity
CYL76_RS12960	COG4702	Belongs to the UPF0303 family
CYL76_RS12970	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
CYL76_RS12970	COG0706	membrane insertase activity
CYL76_RS12980	COG3764	Sortase (surface protein transpeptidase)
CYL76_RS13035	COG1215	transferase activity, transferring glycosyl groups
CYL76_RS13075	COG0789	Transcriptional regulator
CYL76_RS13100	COG0596	Alpha beta hydrolase
CYL76_RS13120	COG0546	phosphoglycolate phosphatase activity
CYL76_RS13130	COG2313	pseudouridylate synthase activity
CYL76_RS13135	COG2733	membrane
CYL76_RS13150	COG4555	ABC transporter
CYL76_RS13190	COG0477	Major facilitator Superfamily
CYL76_RS13205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYL76_RS13215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYL76_RS13220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYL76_RS13225	COG1263	PTS System
CYL76_RS13230	COG1263	PTS System
CYL76_RS13235	COG1234	tRNA 3'-trailer cleavage
CYL76_RS13260	COG1120	ATPase activity
CYL76_RS13265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS13280	COG1113	amino acid transport
CYL76_RS13290	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYL76_RS13300	COG1335	isochorismatase
CYL76_RS13335	COG0277	FAD linked oxidase domain protein
CYL76_RS13345	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYL76_RS13355	COG1174	glycine betaine transport
CYL76_RS13365	COG1174	glycine betaine transport
CYL76_RS13370	COG1732	Glycine betaine
CYL76_RS13385	COG1061	Type III restriction enzyme res subunit
CYL76_RS13390	COG3654	unkown
CYL76_RS13435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CYL76_RS13440	COG0395	ABC-type sugar transport system, permease component
CYL76_RS13445	COG1175	transmembrane transport
CYL76_RS13460	COG1678	Uncharacterized ACR, COG1678
CYL76_RS13465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYL76_RS13470	COG0776	regulation of translation
CYL76_RS13480	COG3973	AAA domain
CYL76_RS13515	COG0583	DNA-binding transcription factor activity
CYL76_RS13555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYL76_RS13560	COG0793	Belongs to the peptidase S41A family
CYL76_RS13565	COG2177	Part of the ABC transporter FtsEX involved in
CYL76_RS13570	COG2884	Cell division ATP-binding protein ftsE
CYL76_RS13585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYL76_RS13620	COG1175	transmembrane transport
CYL76_RS13625	COG0395	ABC-type sugar transport system, permease component
CYL76_RS13635	COG1309	transcriptional regulator
CYL76_RS13650	COG2902	Dehydrogenase
CYL76_RS13675	COG0653	protein targeting
CYL76_RS13690	COG2197	response regulator
CYL76_RS13695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYL76_RS13710	COG5002	protein histidine kinase activity
CYL76_RS13710	COG5000	phosphorelay sensor kinase activity
CYL76_RS13715	COG0745	RESPONSE REGULATOR receiver
CYL76_RS13740	COG0714	Associated with various cellular activities
CYL76_RS13785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYL76_RS13795	COG1482	cell wall glycoprotein biosynthetic process
CYL76_RS13805	COG2835	tetraacyldisaccharide 4'-kinase activity
CYL76_RS13810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYL76_RS13850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYL76_RS13865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYL76_RS13880	COG1316	TRANSCRIPTIONal
CYL76_RS13885	COG1316	TRANSCRIPTIONal
CYL76_RS13905	COG1316	TRANSCRIPTIONal
CYL76_RS13935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYL76_RS13975	COG2205	protein histidine kinase activity
CYL76_RS13980	COG0745	RESPONSE REGULATOR receiver
CYL76_RS13985	COG3104	oligopeptide transport
CYL76_RS14015	COG1366	Belongs to the anti-sigma-factor antagonist family
CYL76_RS14025	COG1228	amidohydrolase
CYL76_RS14035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYL76_RS14040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CYL76_RS14045	COG0531	amino acid
CYL76_RS14090	COG2755	lipolytic protein G-D-S-L family
CYL76_RS14095	COG0183	Belongs to the thiolase family
CYL76_RS14120	COG1136	(ABC) transporter
CYL76_RS14120	COG0577	efflux transmembrane transporter activity
CYL76_RS14125	COG0577	efflux transmembrane transporter activity
CYL76_RS14125	COG1136	(ABC) transporter
CYL76_RS14130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYL76_RS14135	COG1252	NADH dehydrogenase
CYL76_RS14190	COG2124	cytochrome p450
CYL76_RS14285	COG1994	Peptidase M50
CYL76_RS14320	COG3629	intracellular signal transduction
CYL76_RS14320	COG3903	Transcriptional regulator
CYL76_RS14330	COG0577	efflux transmembrane transporter activity
CYL76_RS14335	COG1136	(ABC) transporter
CYL76_RS14375	COG2124	cytochrome p450
CYL76_RS14395	COG1917	Cupin 2, conserved barrel domain protein
CYL76_RS14410	COG1607	acyl-coa hydrolase
CYL76_RS14460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYL76_RS14465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYL76_RS14470	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CYL76_RS14475	COG0193	aminoacyl-tRNA hydrolase activity
CYL76_RS14485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYL76_RS14505	COG4106	trans-aconitate 2-methyltransferase activity
CYL76_RS14515	COG2197	response regulator
CYL76_RS14525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CYL76_RS14540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYL76_RS14590	COG2318	DinB family
CYL76_RS14595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYL76_RS14600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYL76_RS14610	COG0084	hydrolase, TatD family'
CYL76_RS14680	COG0442	prolyl-tRNA aminoacylation
CYL76_RS14735	COG1115	amino acid carrier protein
CYL76_RS14780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CYL76_RS14785	COG1122	ATPase activity
CYL76_RS14795	COG0310	cobalt ion transport
CYL76_RS14805	COG2409	Drug exporters of the RND superfamily
CYL76_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS14840	COG2072	flavoprotein involved in K transport
CYL76_RS14850	COG0708	Exodeoxyribonuclease III
CYL76_RS14865	COG2340	Cysteine-rich secretory protein family
CYL76_RS14910	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYL76_RS14915	COG0315	cyclic pyranopterin monophosphate synthase activity
CYL76_RS14925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYL76_RS14930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYL76_RS14955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CYL76_RS14965	COG1970	mechanosensitive ion channel activity
CYL76_RS14990	COG0243	molybdopterin cofactor binding
CYL76_RS15015	COG0477	Major facilitator Superfamily
CYL76_RS15035	COG3384	dioxygenase
CYL76_RS15040	COG1846	Transcriptional regulator
CYL76_RS15060	COG1021	2,3-dihydroxybenzoate-AMP ligase
CYL76_RS15070	COG2197	response regulator
CYL76_RS15100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYL76_RS15105	COG0475	glutathione-regulated potassium exporter activity
CYL76_RS15130	COG0463	Glycosyl transferase, family 2
CYL76_RS15140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYL76_RS15160	COG3903	Transcriptional regulator
CYL76_RS15160	COG3629	intracellular signal transduction
CYL76_RS15170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYL76_RS15275	COG3655	Transcriptional regulator
CYL76_RS15305	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CYL76_RS15315	COG0768	penicillin binding
CYL76_RS15355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CYL76_RS15380	COG0667	Aldo Keto reductase
CYL76_RS15385	COG1309	transcriptional regulator
CYL76_RS15465	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
CYL76_RS15475	COG0183	Belongs to the thiolase family
CYL76_RS15480	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS15495	COG1309	transcriptional regulator
CYL76_RS15525	COG0318	PFAM AMP-dependent synthetase and ligase
CYL76_RS15540	COG1301	dicarboxylic acid transport
CYL76_RS15555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CYL76_RS15565	COG0163	prenyltransferase activity
CYL76_RS15575	COG0109	protoheme IX farnesyltransferase activity
CYL76_RS15580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYL76_RS15590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYL76_RS15595	COG1333	cytochrome c biogenesis protein
CYL76_RS15600	COG0785	Cytochrome C biogenesis protein
CYL76_RS15685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYL76_RS15705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYL76_RS15740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CYL76_RS15770	COG0113	porphobilinogen synthase activity
CYL76_RS15775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYL76_RS15775	COG1648	precorrin-2 dehydrogenase activity
CYL76_RS15780	COG0181	hydroxymethylbilane synthase activity
CYL76_RS15785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYL76_RS15790	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CYL76_RS15845	COG2223	nitrite transmembrane transporter activity
CYL76_RS15850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYL76_RS15870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYL76_RS15880	COG0842	Transport permease protein
CYL76_RS15880	COG1129	ABC transporter
CYL76_RS15890	COG4991	sh3 domain protein
CYL76_RS15900	COG0129	dihydroxy-acid dehydratase activity
CYL76_RS15910	COG1082	Xylose isomerase domain protein TIM barrel
CYL76_RS15915	COG0248	Ppx GppA phosphatase
CYL76_RS15935	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CYL76_RS15950	COG1194	a g-specific adenine glycosylase
CYL76_RS15955	COG1595	DNA-templated transcription, initiation
CYL76_RS15965	COG0745	RESPONSE REGULATOR receiver
CYL76_RS15970	COG2205	protein histidine kinase activity
CYL76_RS15975	COG0739	heme binding
CYL76_RS16010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CYL76_RS16030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CYL76_RS16045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYL76_RS16070	COG2197	response regulator
CYL76_RS16085	COG0649	NAD binding
CYL76_RS16100	COG1174	glycine betaine transport
CYL76_RS16120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYL76_RS16120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CYL76_RS16140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYL76_RS16155	COG0302	gtp cyclohydrolase
CYL76_RS16170	COG0037	tRNA processing
CYL76_RS16180	COG2027	D-alanyl-D-alanine carboxypeptidase
CYL76_RS16185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYL76_RS16200	COG0586	Pfam SNARE associated Golgi protein
CYL76_RS16205	COG0393	Putative heavy-metal-binding
CYL76_RS16275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYL76_RS16275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYL76_RS16305	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CYL76_RS16330	COG0326	Molecular chaperone. Has ATPase activity
CYL76_RS16340	COG2197	response regulator
CYL76_RS16345	COG4585	Histidine kinase
CYL76_RS16410	COG0494	nUDIX hydrolase
CYL76_RS16440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYL76_RS16455	COG2890	protein-(glutamine-N5) methyltransferase activity
CYL76_RS16465	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CYL76_RS16475	COG1366	Belongs to the anti-sigma-factor antagonist family
CYL76_RS16545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYL76_RS16560	COG2267	carboxylic ester hydrolase activity
CYL76_RS16590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYL76_RS16635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYL76_RS16640	COG1610	YqeY-like protein
CYL76_RS16645	COG1408	metallophosphoesterase
CYL76_RS16740	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CYL76_RS16745	COG1937	Protein conserved in bacteria
CYL76_RS16760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYL76_RS16760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYL76_RS16775	COG0659	secondary active sulfate transmembrane transporter activity
CYL76_RS16795	COG2755	lipolytic protein G-D-S-L family
CYL76_RS16805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CYL76_RS16825	COG1595	DNA-templated transcription, initiation
CYL76_RS16850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYL76_RS16855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYL76_RS16870	COG1802	Transcriptional regulator
CYL76_RS16895	COG0738	Major facilitator superfamily
CYL76_RS16905	COG3226	Transcriptional regulator
CYL76_RS16915	COG0592	DNA-directed DNA polymerase activity
CYL76_RS16925	COG0667	Aldo Keto reductase
CYL76_RS16960	COG0662	Cupin 2, conserved barrel domain protein
CYL76_RS16965	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS17020	COG0590	tRNA wobble adenosine to inosine editing
CYL76_RS17030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CYL76_RS17035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYL76_RS17055	COG2124	cytochrome p450
CYL76_RS17060	COG2197	response regulator
CYL76_RS17070	COG0702	epimerase
CYL76_RS17095	COG0477	Major facilitator Superfamily
CYL76_RS17105	COG0191	fructose-bisphosphate aldolase activity
CYL76_RS17110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYL76_RS17125	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYL76_RS17150	COG0542	response to heat
CYL76_RS17180	COG0789	Transcriptional regulator
CYL76_RS17185	COG0484	heat shock protein binding
CYL76_RS17190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYL76_RS17195	COG0443	Heat shock 70 kDa protein
CYL76_RS17205	COG2181	nitrate reductase activity
CYL76_RS17205	COG0247	lactate metabolic process
CYL76_RS17220	COG0717	Belongs to the dCTP deaminase family
CYL76_RS17255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYL76_RS17275	COG2217	Heavy metal translocating P-type atpase
CYL76_RS17330	COG1309	transcriptional regulator
CYL76_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS17350	COG3851	Histidine kinase
CYL76_RS17360	COG0477	Major facilitator Superfamily
CYL76_RS17375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYL76_RS17390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYL76_RS17395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL76_RS17420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYL76_RS17425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL76_RS17430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CYL76_RS17435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYL76_RS17480	COG2205	protein histidine kinase activity
CYL76_RS17485	COG0745	RESPONSE REGULATOR receiver
CYL76_RS17510	COG1533	DNA photolyase activity
CYL76_RS17520	COG2130	NADP-dependent
CYL76_RS17540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYL76_RS17550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYL76_RS17570	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS17585	COG0367	asparagine synthase
CYL76_RS17600	COG1902	pentaerythritol trinitrate reductase activity
CYL76_RS17625	COG2205	protein histidine kinase activity
CYL76_RS17630	COG0745	RESPONSE REGULATOR receiver
CYL76_RS17655	COG1609	Transcriptional regulator
CYL76_RS17695	COG2124	cytochrome p450
CYL76_RS17700	COG2124	cytochrome p450
CYL76_RS17725	COG3585	molybdate ion transport
CYL76_RS17760	COG0475	glutathione-regulated potassium exporter activity
CYL76_RS17770	COG2409	Drug exporters of the RND superfamily
CYL76_RS17775	COG0513	Belongs to the DEAD box helicase family
CYL76_RS17780	COG1278	Cold shock
CYL76_RS17845	COG2268	Band 7 protein
CYL76_RS17910	COG2255	four-way junction helicase activity
CYL76_RS17925	COG0180	Tryptophanyl-tRNA synthetase
CYL76_RS17935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL76_RS17950	COG1672	PFAM Archaeal ATPase
CYL76_RS17950	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CYL76_RS17965	COG0431	NADPH-dependent FMN reductase
CYL76_RS17995	COG2205	protein histidine kinase activity
CYL76_RS18000	COG0745	RESPONSE REGULATOR receiver
CYL76_RS18005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYL76_RS18020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYL76_RS18035	COG1741	Belongs to the pirin family
CYL76_RS18045	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS18050	COG1362	aminopeptidase activity
CYL76_RS18070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYL76_RS18125	COG0022	dehydrogenase e1 component
CYL76_RS18170	COG4591	ABC-type transport system involved in lipoprotein release permease component
CYL76_RS18170	COG1136	(ABC) transporter
CYL76_RS18190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYL76_RS18200	COG0746	molybdenum cofactor guanylyltransferase activity
CYL76_RS18220	COG1522	sequence-specific DNA binding
CYL76_RS18225	COG1309	transcriptional regulator
CYL76_RS18250	COG3396	Phenylacetate-CoA oxygenase
CYL76_RS18255	COG3460	Phenylacetate-CoA oxygenase
CYL76_RS18260	COG3396	Phenylacetate-CoA oxygenase
CYL76_RS18265	COG2151	metal-sulfur cluster biosynthetic enzyme
CYL76_RS18275	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS18280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYL76_RS18310	COG1716	ATPase activity
CYL76_RS18325	COG0768	penicillin binding
CYL76_RS18330	COG0515	serine threonine protein kinase
CYL76_RS18335	COG3764	Sortase (surface protein transpeptidase)
CYL76_RS18370	COG0705	Rhomboid family
CYL76_RS18425	COG0582	viral genome integration into host DNA
CYL76_RS18445	COG1595	DNA-templated transcription, initiation
CYL76_RS18840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYL76_RS18850	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CYL76_RS18855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYL76_RS18860	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CYL76_RS18865	COG0592	DNA-directed DNA polymerase activity
CYL76_RS18885	COG0594	ribonuclease P activity
CYL76_RS18890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYL76_RS18895	COG0706	membrane insertase activity
CYL76_RS18910	COG1192	Involved in chromosome partitioning
CYL76_RS18925	COG3118	belongs to the thioredoxin family
CYL76_RS18930	COG0492	ferredoxin-NADP+ reductase activity
CYL76_RS18940	COG1595	DNA-templated transcription, initiation
CYL76_RS18945	COG2815	serine threonine protein kinase
CYL76_RS18945	COG0515	serine threonine protein kinase
CYL76_RS18960	COG0617	tRNA 3'-terminal CCA addition
CYL76_RS19005	COG0360	Binds together with S18 to 16S ribosomal RNA
CYL76_RS19010	COG0629	single-stranded DNA binding
CYL76_RS19015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYL76_RS19020	COG0359	binds to the 23S rRNA
CYL76_RS19025	COG0534	Mate efflux family protein
CYL76_RS19030	COG0305	Participates in initiation and elongation during chromosome replication
CYL76_RS19060	COG2814	Major facilitator Superfamily
CYL76_RS19080	COG0626	cystathionine gamma-synthase activity
CYL76_RS19085	COG1950	PFAM Membrane protein of
CYL76_RS19090	COG0662	Cupin 2, conserved barrel domain protein
CYL76_RS19115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CYL76_RS19120	COG3152	Membrane
CYL76_RS19135	COG1609	Transcriptional regulator
CYL76_RS19140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYL76_RS19145	COG1271	oxidase subunit
CYL76_RS19150	COG1294	oxidase, subunit
CYL76_RS19155	COG4988	ABC transporter
CYL76_RS19165	COG0561	phosphatase activity
CYL76_RS19175	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CYL76_RS19180	COG0789	Transcriptional regulator
CYL76_RS19195	COG1131	(ABC) transporter
CYL76_RS19220	COG0561	phosphatase activity
CYL76_RS19225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYL76_RS19230	COG0077	Prephenate dehydratase
CYL76_RS19235	COG2837	iron assimilation
CYL76_RS19240	COG2372	response to copper ion
CYL76_RS19250	COG1999	signal sequence binding
CYL76_RS19270	COG0006	proline dipeptidase activity
CYL76_RS19290	COG0653	protein targeting
CYL76_RS19370	COG1725	Transcriptional regulator
CYL76_RS19415	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS19440	COG1595	DNA-templated transcription, initiation
CYL76_RS19445	COG0318	PFAM AMP-dependent synthetase and ligase
CYL76_RS19480	COG2186	Transcriptional regulator
CYL76_RS19525	COG0745	RESPONSE REGULATOR receiver
CYL76_RS19530	COG2205	protein histidine kinase activity
CYL76_RS19555	COG0477	Major facilitator Superfamily
CYL76_RS19570	COG3467	pyridoxamine 5'-phosphate
CYL76_RS19575	COG2353	YceI-like domain
CYL76_RS19600	COG1191	sigma factor activity
CYL76_RS19605	COG1191	sigma factor activity
CYL76_RS19620	COG1518	maintenance of DNA repeat elements
CYL76_RS19690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYL76_RS19750	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CYL76_RS19785	COG0492	ferredoxin-NADP+ reductase activity
CYL76_RS19825	COG0151	Belongs to the GarS family
CYL76_RS19840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYL76_RS19850	COG2197	response regulator
CYL76_RS19870	COG1131	(ABC) transporter
CYL76_RS19890	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYL76_RS19895	COG0047	phosphoribosylformylglycinamidine synthase activity
CYL76_RS19900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYL76_RS19910	COG0739	heme binding
CYL76_RS19910	COG0741	lytic transglycosylase activity
CYL76_RS19910	COG1196	nuclear chromosome segregation
CYL76_RS19930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYL76_RS19965	COG1643	Atp-dependent helicase
CYL76_RS19975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYL76_RS19975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYL76_RS19980	COG0785	Cytochrome C biogenesis protein
CYL76_RS20015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYL76_RS20025	COG0513	Belongs to the DEAD box helicase family
CYL76_RS20075	COG0789	Transcriptional regulator
CYL76_RS20085	COG0741	lytic transglycosylase activity
CYL76_RS20085	COG1196	nuclear chromosome segregation
CYL76_RS20085	COG0739	heme binding
CYL76_RS20095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYL76_RS20125	COG1252	NADH dehydrogenase
CYL76_RS20140	COG1846	Transcriptional regulator
CYL76_RS20215	COG1196	nuclear chromosome segregation
CYL76_RS20215	COG0741	lytic transglycosylase activity
CYL76_RS20215	COG0739	heme binding
CYL76_RS20220	COG0671	phosphoesterase, PA-phosphatase related
CYL76_RS20235	COG1937	Protein conserved in bacteria
CYL76_RS20245	COG0306	phosphate transporter
CYL76_RS20265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYL76_RS20290	COG1116	anion transmembrane transporter activity
CYL76_RS20305	COG0456	acetyltransferase
CYL76_RS20330	COG0737	Belongs to the 5'-nucleotidase family
CYL76_RS20355	COG0154	amidase activity
CYL76_RS20380	COG0640	Transcriptional regulator
CYL76_RS20385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYL76_RS20430	COG0789	Transcriptional regulator
CYL76_RS20465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYL76_RS20475	COG0745	RESPONSE REGULATOR receiver
CYL76_RS20500	COG2897	thiosulfate sulfurtransferase activity
CYL76_RS20540	COG3485	protocatechuate 3,4-dioxygenase
CYL76_RS20545	COG0735	belongs to the Fur family
CYL76_RS20555	COG1490	D-aminoacyl-tRNA deacylase activity
CYL76_RS20570	COG4552	Acetyltransferase involved in intracellular survival and related
CYL76_RS20605	COG2318	DinB family
CYL76_RS20685	COG0588	phosphoglycerate mutase activity
CYL76_RS20700	COG5002	protein histidine kinase activity
CYL76_RS20720	COG1329	Transcriptional regulator
CYL76_RS20725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYL76_RS20730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYL76_RS20740	COG0215	cysteine-tRNA ligase activity
CYL76_RS20755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYL76_RS20765	COG3842	ATPase activity
CYL76_RS20905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYL76_RS20930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CYL76_RS20950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYL76_RS20950	COG1877	trehalose-phosphatase activity
CYL76_RS20960	COG0463	Glycosyl transferase, family 2
CYL76_RS21010	COG1132	(ABC) transporter
CYL76_RS21025	COG1595	DNA-templated transcription, initiation
CYL76_RS21065	COG0395	ABC-type sugar transport system, permease component
CYL76_RS21070	COG1175	transmembrane transport
CYL76_RS21120	COG2197	response regulator
CYL76_RS21140	COG1263	PTS System
CYL76_RS21140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYL76_RS21145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CYL76_RS21150	COG1737	Transcriptional regulator
CYL76_RS21185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CYL76_RS21190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CYL76_RS21195	COG1984	allophanate hydrolase subunit 2
CYL76_RS21205	COG3142	Participates in the control of copper homeostasis
CYL76_RS21210	COG3973	AAA domain
CYL76_RS21225	COG1061	Type III restriction enzyme res subunit
CYL76_RS21230	COG1846	Transcriptional regulator
CYL76_RS21255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYL76_RS21260	COG1120	ATPase activity
CYL76_RS21265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS21270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS21290	COG1278	Cold shock
CYL76_RS21295	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CYL76_RS21300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYL76_RS21330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CYL76_RS21340	COG2252	PERMEase
CYL76_RS21380	COG0667	Aldo Keto reductase
CYL76_RS21385	COG2267	carboxylic ester hydrolase activity
CYL76_RS21420	COG0515	serine threonine protein kinase
CYL76_RS21425	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS21435	COG0583	DNA-binding transcription factor activity
CYL76_RS21505	COG1051	belongs to the nudix hydrolase family
CYL76_RS21525	COG1309	transcriptional regulator
CYL76_RS21535	COG0697	spore germination
CYL76_RS21600	COG1335	isochorismatase
CYL76_RS21620	COG1302	Protein conserved in bacteria
CYL76_RS21630	COG2318	DinB family
CYL76_RS21640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CYL76_RS21670	COG2205	protein histidine kinase activity
CYL76_RS21680	COG3896	Chloramphenicol phosphotransferase-like protein
CYL76_RS21710	COG1051	belongs to the nudix hydrolase family
CYL76_RS21725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYL76_RS21745	COG1024	Enoyl-CoA hydratase
CYL76_RS21785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYL76_RS21810	COG2124	cytochrome p450
CYL76_RS21840	COG0259	pyridoxamine-phosphate oxidase activity
CYL76_RS21850	COG1136	(ABC) transporter
CYL76_RS21850	COG0577	efflux transmembrane transporter activity
CYL76_RS21855	COG1136	(ABC) transporter
CYL76_RS21855	COG0577	efflux transmembrane transporter activity
CYL76_RS21870	COG0745	RESPONSE REGULATOR receiver
CYL76_RS21875	COG2205	protein histidine kinase activity
CYL76_RS21880	COG4821	SIS domain
CYL76_RS21890	COG2267	carboxylic ester hydrolase activity
CYL76_RS21930	COG0477	Major facilitator Superfamily
CYL76_RS21945	COG2264	protein methyltransferase activity
CYL76_RS21960	COG0151	Belongs to the GarS family
CYL76_RS22040	COG0318	PFAM AMP-dependent synthetase and ligase
CYL76_RS22055	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS22075	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS22080	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS22180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYL76_RS22210	COG1024	Enoyl-CoA hydratase
CYL76_RS22225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYL76_RS22240	COG2072	flavoprotein involved in K transport
CYL76_RS22250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS22255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS22285	COG0501	Belongs to the peptidase M48B family
CYL76_RS22290	COG0259	pyridoxamine-phosphate oxidase activity
CYL76_RS22310	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS22320	COG1309	transcriptional regulator
CYL76_RS22395	COG1278	Cold shock
CYL76_RS22400	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CYL76_RS22410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CYL76_RS22440	COG2226	methyltransferase
CYL76_RS22460	COG2364	Membrane
CYL76_RS22465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYL76_RS22530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYL76_RS22535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYL76_RS22540	COG0649	NAD binding
CYL76_RS22550	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CYL76_RS22555	COG1034	ATP synthesis coupled electron transport
CYL76_RS22560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CYL76_RS22565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYL76_RS22570	COG0839	Belongs to the complex I subunit 6 family
CYL76_RS22575	COG0713	ATP synthesis coupled electron transport
CYL76_RS22580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYL76_RS22590	COG1007	ATP synthesis coupled electron transport
CYL76_RS22635	COG1131	(ABC) transporter
CYL76_RS22660	COG0561	phosphatase activity
CYL76_RS22700	COG0702	epimerase
CYL76_RS22705	COG1733	regulation of RNA biosynthetic process
CYL76_RS22710	COG1013	pyruvate-flavodoxin oxidoreductase activity
CYL76_RS22735	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYL76_RS22750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CYL76_RS22755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYL76_RS22760	COG0839	Belongs to the complex I subunit 6 family
CYL76_RS22765	COG0713	ATP synthesis coupled electron transport
CYL76_RS22785	COG1970	mechanosensitive ion channel activity
CYL76_RS22790	COG0501	Belongs to the peptidase M48B family
CYL76_RS22795	COG3304	Inner membrane component domain
CYL76_RS22800	COG2261	transglycosylase associated protein
CYL76_RS22810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CYL76_RS22815	COG1666	GTP binding
CYL76_RS22845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYL76_RS22850	COG2030	dehydratase
CYL76_RS22860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYL76_RS22875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CYL76_RS22880	COG0436	Aminotransferase
CYL76_RS22900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYL76_RS22905	COG0081	regulation of translation
CYL76_RS22915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYL76_RS22920	COG0222	ribosome binding
CYL76_RS22930	COG0085	RNA polymerase activity
CYL76_RS23045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYL76_RS23050	COG0049	tRNA binding
CYL76_RS23055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYL76_RS23060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYL76_RS23085	COG0051	transcription antitermination factor activity, RNA binding
CYL76_RS23090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYL76_RS23095	COG0088	Forms part of the polypeptide exit tunnel
CYL76_RS23100	COG0089	rRNA binding
CYL76_RS23105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYL76_RS23110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYL76_RS23115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYL76_RS23120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYL76_RS23125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYL76_RS23130	COG0255	Belongs to the universal ribosomal protein uL29 family
CYL76_RS23135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYL76_RS23140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CYL76_RS23145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYL76_RS23150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYL76_RS23155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYL76_RS23165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYL76_RS23170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYL76_RS23175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYL76_RS23180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYL76_RS23185	COG1841	ribosomal large subunit assembly
CYL76_RS23190	COG0200	Binds to the 23S rRNA
CYL76_RS23200	COG0563	adenylate kinase activity
CYL76_RS23210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYL76_RS23215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYL76_RS23220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYL76_RS23225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYL76_RS23230	COG0202	RNA polymerase activity
CYL76_RS23235	COG0203	ribosomal protein L17
CYL76_RS23250	COG0488	(ABC) transporter
CYL76_RS23255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYL76_RS23260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYL76_RS23265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYL76_RS23275	COG1072	(Pantothenic acid kinase))
CYL76_RS23300	COG0747	negative chemotaxis
CYL76_RS23305	COG3795	YCII-related domain
CYL76_RS23310	COG4941	Belongs to the sigma-70 factor family
CYL76_RS23330	COG0736	holo-[acyl-carrier-protein] synthase activity
CYL76_RS23340	COG3189	MarR family transcriptional regulator
CYL76_RS23345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYL76_RS23355	COG0802	atpase or kinase
CYL76_RS23380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYL76_RS23415	COG0726	polysaccharide deacetylase
CYL76_RS23420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYL76_RS23440	COG0583	DNA-binding transcription factor activity
CYL76_RS23455	COG1595	DNA-templated transcription, initiation
CYL76_RS23470	COG0516	GMP reductase activity
CYL76_RS23485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CYL76_RS23505	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS23565	COG2197	response regulator
CYL76_RS23600	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYL76_RS23600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYL76_RS23625	COG0714	Associated with various cellular activities
CYL76_RS23640	COG0045	succinate-CoA ligase (ADP-forming) activity
CYL76_RS23670	COG0138	bifunctional purine biosynthesis protein purh
CYL76_RS23680	COG1714	RDD family
CYL76_RS23685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYL76_RS23700	COG0039	L-malate dehydrogenase activity
CYL76_RS23705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYL76_RS23710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYL76_RS23720	COG0754	glutathionylspermidine amidase activity
CYL76_RS23725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYL76_RS23730	COG0180	Tryptophanyl-tRNA synthetase
CYL76_RS23750	COG1295	ribonuclease BN
CYL76_RS23755	COG1686	Belongs to the peptidase S11 family
CYL76_RS23765	COG1408	metallophosphoesterase
CYL76_RS23795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CYL76_RS23810	COG2009	succinate dehydrogenase
CYL76_RS23860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYL76_RS23930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYL76_RS23940	COG1216	Glycosyl transferase, family 2
CYL76_RS23955	COG2089	acid synthase
CYL76_RS23965	COG1473	amidohydrolase
CYL76_RS23965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYL76_RS23970	COG1744	ABC transporter substrate-binding protein PnrA-like
CYL76_RS23975	COG3845	ABC transporter
CYL76_RS23980	COG4603	Belongs to the binding-protein-dependent transport system permease family
CYL76_RS23985	COG1079	Belongs to the binding-protein-dependent transport system permease family
CYL76_RS24005	COG1404	Belongs to the peptidase S8 family
CYL76_RS24025	COG2814	Major facilitator Superfamily
CYL76_RS24030	COG0583	DNA-binding transcription factor activity
CYL76_RS24045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CYL76_RS24070	COG2205	protein histidine kinase activity
CYL76_RS24075	COG0745	RESPONSE REGULATOR receiver
CYL76_RS24080	COG1595	DNA-templated transcription, initiation
CYL76_RS24110	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS24115	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS24130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYL76_RS24155	COG1349	DNA-binding transcription factor activity
CYL76_RS24165	COG4770	biotin carboxylase activity
CYL76_RS24175	COG0424	maF-like protein
CYL76_RS24185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYL76_RS24200	COG1024	Enoyl-CoA hydratase
CYL76_RS24240	COG1376	ErfK ybiS ycfS ynhG family protein
CYL76_RS24260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYL76_RS24265	COG1396	sequence-specific DNA binding
CYL76_RS24280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYL76_RS24300	COG1595	DNA-templated transcription, initiation
CYL76_RS24305	COG2255	four-way junction helicase activity
CYL76_RS24310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYL76_RS24325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYL76_RS24335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CYL76_RS24365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYL76_RS24365	COG0515	serine threonine protein kinase
CYL76_RS24385	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CYL76_RS24455	COG2188	Transcriptional regulator
CYL76_RS24465	COG1674	ftsk spoiiie
CYL76_RS24480	COG4974	Belongs to the 'phage' integrase family
CYL76_RS24530	COG0251	oxidation-reduction process
CYL76_RS24535	COG2610	gluconate transmembrane transporter activity
CYL76_RS24565	COG2894	cell division
CYL76_RS24595	COG3920	Histidine kinase
CYL76_RS24620	COG2885	chlorophyll binding
CYL76_RS24675	COG0667	Aldo Keto reductase
CYL76_RS24680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYL76_RS24685	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CYL76_RS24700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYL76_RS24705	COG0450	alkyl hydroperoxide reductase
CYL76_RS24720	COG1136	(ABC) transporter
CYL76_RS24740	COG4499	WXG100 protein secretion system (Wss), protein YukC
CYL76_RS24740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYL76_RS24755	COG0114	fumarate hydratase activity
CYL76_RS24765	COG1362	aminopeptidase activity
CYL76_RS24770	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CYL76_RS24770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CYL76_RS24795	COG0778	Nitroreductase
CYL76_RS24800	COG1722	exodeoxyribonuclease VII activity
CYL76_RS24805	COG1570	exodeoxyribonuclease VII activity
CYL76_RS24815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYL76_RS24830	COG0012	GTP binding
CYL76_RS25045	COG0463	Glycosyl transferase, family 2
CYL76_RS25055	COG4941	Belongs to the sigma-70 factor family
CYL76_RS25060	COG3795	YCII-related domain
CYL76_RS25095	COG0148	phosphopyruvate hydratase activity
CYL76_RS25125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CYL76_RS25130	COG2226	methyltransferase
CYL76_RS25145	COG1217	gtp-binding protein TYPA
CYL76_RS25155	COG0747	negative chemotaxis
CYL76_RS25160	COG0601	transmembrane transport
CYL76_RS25170	COG0444	Belongs to the ABC transporter superfamily
CYL76_RS25175	COG4608	Belongs to the ABC transporter superfamily
CYL76_RS25180	COG4166	transmembrane transport
CYL76_RS25185	COG0601	transmembrane transport
CYL76_RS25190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL76_RS25200	COG4608	Belongs to the ABC transporter superfamily
CYL76_RS25205	COG2197	response regulator
CYL76_RS25220	COG0577	efflux transmembrane transporter activity
CYL76_RS25220	COG1136	(ABC) transporter
CYL76_RS25250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CYL76_RS25280	COG0110	maltose O-acetyltransferase activity
CYL76_RS25295	COG0515	serine threonine protein kinase
CYL76_RS25305	COG1132	(ABC) transporter
CYL76_RS25310	COG1132	(ABC) transporter
CYL76_RS25315	COG2197	response regulator
CYL76_RS25320	COG2912	Transglutaminase-like superfamily
CYL76_RS25350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYL76_RS25355	COG1611	Belongs to the LOG family
CYL76_RS25360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYL76_RS25370	COG0519	Catalyzes the synthesis of GMP from XMP
CYL76_RS25375	COG1024	Enoyl-CoA hydratase
CYL76_RS25390	COG1595	DNA-templated transcription, initiation
CYL76_RS25400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYL76_RS25405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYL76_RS25440	COG0598	Magnesium transport protein CorA
CYL76_RS25460	COG2095	MarC family integral membrane protein
CYL76_RS25465	COG1432	Conserved Protein
CYL76_RS25480	COG0513	Belongs to the DEAD box helicase family
CYL76_RS25520	COG0747	negative chemotaxis
CYL76_RS25685	COG3480	Lon protease (S16) C-terminal proteolytic domain
CYL76_RS25720	COG0753	catalase activity
CYL76_RS25730	COG0483	inositol monophosphate 1-phosphatase activity
CYL76_RS25740	COG2076	Multidrug Resistance protein
CYL76_RS25745	COG1162	GTPase activity
CYL76_RS25750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYL76_RS25760	COG2135	peptidase activity
CYL76_RS25770	COG1595	DNA-templated transcription, initiation
CYL76_RS25775	COG5662	AntiSigma factor
CYL76_RS25785	COG0242	peptide deformylase activity
CYL76_RS25870	COG1966	Carbon starvation protein
CYL76_RS25880	COG2182	Extracellular solute-binding protein
CYL76_RS25885	COG1175	transmembrane transport
CYL76_RS25890	COG0395	ABC-type sugar transport system, permease component
CYL76_RS25900	COG0363	glucosamine-6-phosphate deaminase activity
CYL76_RS25905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYL76_RS25920	COG1597	lipid kinase activity
CYL76_RS25935	COG2172	sigma factor antagonist activity
CYL76_RS26000	COG1959	2 iron, 2 sulfur cluster binding
CYL76_RS26010	COG0142	geranyltranstransferase activity
CYL76_RS26090	COG4106	trans-aconitate 2-methyltransferase activity
CYL76_RS26095	COG1126	abc transporter atp-binding protein
CYL76_RS26100	COG0765	amino acid transport
CYL76_RS26105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL76_RS26115	COG0281	malic enzyme
CYL76_RS26120	COG0604	alcohol dehydrogenase
CYL76_RS26140	COG0542	response to heat
CYL76_RS26165	COG0567	Dehydrogenase, E1 component
CYL76_RS26165	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYL76_RS26180	COG0745	RESPONSE REGULATOR receiver
CYL76_RS26220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL76_RS26245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYL76_RS26255	COG0438	transferase activity, transferring glycosyl groups
CYL76_RS26270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYL76_RS26295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYL76_RS26300	COG0726	polysaccharide deacetylase
CYL76_RS26345	COG0791	NLP P60 protein
CYL76_RS26345	COG3883	PFAM NLP P60 protein
CYL76_RS26360	COG1309	transcriptional regulator
CYL76_RS26390	COG0768	penicillin binding
CYL76_RS26445	COG1201	RNA secondary structure unwinding
CYL76_RS26550	COG0018	arginyl-trna synthetase
CYL76_RS26555	COG0019	diaminopimelate decarboxylase activity
CYL76_RS26560	COG0460	homoserine dehydrogenase
CYL76_RS26565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYL76_RS26570	COG0083	homoserine kinase activity
CYL76_RS26580	COG1316	TRANSCRIPTIONal
CYL76_RS26585	COG0254	rRNA binding
CYL76_RS26590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYL76_RS26595	COG2890	protein-(glutamine-N5) methyltransferase activity
CYL76_RS26610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYL76_RS26630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYL76_RS26635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYL76_RS26640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYL76_RS26645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYL76_RS26650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYL76_RS26655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYL76_RS26660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYL76_RS26675	COG2197	response regulator
CYL76_RS26680	COG3850	Histidine kinase
CYL76_RS26695	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYL76_RS26710	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CYL76_RS26765	COG0183	Belongs to the thiolase family
CYL76_RS26870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYL76_RS26870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYL76_RS26915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CYL76_RS26935	COG4565	transcriptional regulatory protein
CYL76_RS26945	COG1301	dicarboxylic acid transport
CYL76_RS26955	COG3281	Trehalose synthase
CYL76_RS26960	COG0366	Alpha amylase catalytic
CYL76_RS26965	COG0366	Alpha amylase catalytic
CYL76_RS26970	COG0058	SHG alpha-glucan phosphorylase activity
CYL76_RS26995	COG1132	(ABC) transporter
CYL76_RS27000	COG1132	(ABC) transporter
CYL76_RS27005	COG1131	(ABC) transporter
CYL76_RS27185	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS27200	COG2235	arginine
CYL76_RS27275	COG1760	l-serine dehydratase
CYL76_RS27335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYL76_RS27370	COG0252	asparaginase activity
CYL76_RS27435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYL76_RS27480	COG1760	l-serine dehydratase
CYL76_RS27485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYL76_RS27490	COG0509	glycine decarboxylation via glycine cleavage system
CYL76_RS27495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYL76_RS27515	COG4166	transmembrane transport
CYL76_RS27520	COG0601	transmembrane transport
CYL76_RS27525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL76_RS27530	COG0444	Belongs to the ABC transporter superfamily
CYL76_RS27535	COG4608	Belongs to the ABC transporter superfamily
CYL76_RS27540	COG2860	membrane
CYL76_RS27590	COG4221	oxidoreductase activity
CYL76_RS27600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYL76_RS27610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYL76_RS27615	COG0154	amidase activity
CYL76_RS27625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYL76_RS27630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CYL76_RS27640	COG2409	Drug exporters of the RND superfamily
CYL76_RS27655	COG2133	pyrroloquinoline quinone binding
CYL76_RS27660	COG0667	Aldo Keto reductase
CYL76_RS27680	COG0440	acetolactate synthase activity
CYL76_RS27685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYL76_RS27720	COG0506	proline dehydrogenase activity
CYL76_RS27750	COG0473	3-isopropylmalate dehydrogenase activity
CYL76_RS27755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYL76_RS27760	COG2957	Belongs to the agmatine deiminase family
CYL76_RS27770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYL76_RS27785	COG4608	Belongs to the ABC transporter superfamily
CYL76_RS27795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL76_RS27800	COG0444	Belongs to the ABC transporter superfamily
CYL76_RS27810	COG1472	Belongs to the glycosyl hydrolase 3 family
CYL76_RS27830	COG2207	Transcriptional regulator
CYL76_RS27830	COG3708	Transcriptional regulator
CYL76_RS27855	COG0492	ferredoxin-NADP+ reductase activity
CYL76_RS27880	COG1733	regulation of RNA biosynthetic process
CYL76_RS27980	COG2018	Roadblock/LC7 domain
CYL76_RS28000	COG2018	Roadblock/LC7 domain
CYL76_RS28015	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYL76_RS28020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYL76_RS28055	COG1414	Transcriptional regulator
CYL76_RS28060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYL76_RS28065	COG0066	3-isopropylmalate dehydratase activity
CYL76_RS28075	COG0776	regulation of translation
CYL76_RS28085	COG1920	GTP binding
CYL76_RS28115	COG0351	phosphomethylpyrimidine kinase
CYL76_RS28120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYL76_RS28125	COG1461	Dihydroxyacetone kinase
CYL76_RS28135	COG0742	ribosomal rna small subunit methyltransferase
CYL76_RS28140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYL76_RS28155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYL76_RS28170	COG1733	regulation of RNA biosynthetic process
CYL76_RS28175	COG2340	Cysteine-rich secretory protein family
CYL76_RS28185	COG1254	Belongs to the acylphosphatase family
CYL76_RS28205	COG0477	Major facilitator Superfamily
CYL76_RS28260	COG0228	four-way junction DNA binding
CYL76_RS28265	COG1837	Belongs to the UPF0109 family
CYL76_RS28270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYL76_RS28275	COG0336	Belongs to the RNA methyltransferase TrmD family
CYL76_RS28280	COG0335	large ribosomal subunit rRNA binding
CYL76_RS28295	COG0681	Belongs to the peptidase S26 family
CYL76_RS28300	COG0681	Belongs to the peptidase S26 family
CYL76_RS28330	COG1191	sigma factor activity
CYL76_RS28345	COG0052	Belongs to the universal ribosomal protein uS2 family
CYL76_RS28350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYL76_RS28355	COG0528	UMP kinase activity
CYL76_RS28360	COG0233	cytoplasmic translational termination
CYL76_RS28385	COG3842	ATPase activity
CYL76_RS28400	COG1136	(ABC) transporter
CYL76_RS28405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYL76_RS28415	COG1012	belongs to the aldehyde dehydrogenase family
CYL76_RS28440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CYL76_RS28460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CYL76_RS28465	COG3842	ATPase activity
CYL76_RS28470	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYL76_RS28475	COG1177	transmembrane transport
CYL76_RS28480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYL76_RS28515	COG2508	Transcriptional regulator
CYL76_RS28550	COG0750	zinc metalloprotease
CYL76_RS28555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYL76_RS28570	COG0442	prolyl-tRNA aminoacylation
CYL76_RS28590	COG0779	Required for maturation of 30S ribosomal subunits
CYL76_RS28615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYL76_RS28620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYL76_RS28650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL76_RS28655	COG0601	transmembrane transport
CYL76_RS28660	COG0747	negative chemotaxis
CYL76_RS28665	COG0455	bacterial-type flagellum organization
CYL76_RS28685	COG3266	domain, Protein
CYL76_RS28690	COG1404	Belongs to the peptidase S8 family
CYL76_RS28730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYL76_RS28735	COG1185	polyribonucleotide nucleotidyltransferase activity
CYL76_RS28745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYL76_RS28765	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CYL76_RS28775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CYL76_RS28840	COG1058	Belongs to the CinA family
CYL76_RS28840	COG1546	Belongs to the CinA family
CYL76_RS28845	COG1396	sequence-specific DNA binding
CYL76_RS28850	COG0783	Belongs to the Dps family
CYL76_RS28865	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS28925	COG2197	response regulator
CYL76_RS28955	COG0640	Transcriptional regulator
CYL76_RS28960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYL76_RS28990	COG0765	amino acid transport
CYL76_RS28995	COG0765	amino acid transport
CYL76_RS29000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL76_RS29005	COG1126	abc transporter atp-binding protein
CYL76_RS29015	COG2205	protein histidine kinase activity
CYL76_RS29020	COG2358	TRAP transporter, solute receptor (TAXI family
CYL76_RS29025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYL76_RS29040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYL76_RS29060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYL76_RS29075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYL76_RS29115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYL76_RS29125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYL76_RS29160	COG2197	response regulator
CYL76_RS29170	COG0596	Alpha beta hydrolase
CYL76_RS29250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYL76_RS29295	COG2186	Transcriptional regulator
CYL76_RS29305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYL76_RS29330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYL76_RS29335	COG4565	transcriptional regulatory protein
CYL76_RS29340	COG3290	protein histidine kinase activity
CYL76_RS29355	COG0372	Belongs to the citrate synthase family
CYL76_RS29365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYL76_RS29370	COG0612	Peptidase, M16
CYL76_RS29385	COG1802	Transcriptional regulator
CYL76_RS29390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYL76_RS29410	COG1435	thymidine kinase activity
CYL76_RS29450	COG0483	inositol monophosphate 1-phosphatase activity
CYL76_RS29455	COG0745	RESPONSE REGULATOR receiver
CYL76_RS29460	COG2205	protein histidine kinase activity
CYL76_RS29485	COG0756	dUTP diphosphatase activity
CYL76_RS29520	COG0569	domain protein
CYL76_RS29525	COG0531	amino acid
CYL76_RS29530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYL76_RS29570	COG0596	Alpha beta hydrolase
CYL76_RS29580	COG0745	RESPONSE REGULATOR receiver
CYL76_RS29615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYL76_RS29665	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYL76_RS29670	COG3629	intracellular signal transduction
CYL76_RS29685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYL76_RS29710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYL76_RS29725	COG0515	serine threonine protein kinase
CYL76_RS29725	COG2815	serine threonine protein kinase
CYL76_RS29745	COG2366	antibiotic biosynthetic process
CYL76_RS29765	COG3629	intracellular signal transduction
CYL76_RS29765	COG3903	Transcriptional regulator
CYL76_RS29785	COG0464	growth
CYL76_RS29950	COG0505	Belongs to the CarA family
CYL76_RS29960	COG1280	lysine exporter protein (LysE YggA)
CYL76_RS29965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYL76_RS29975	COG3291	Pkd domain containing protein
CYL76_RS29980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYL76_RS30000	COG3938	Belongs to the proline racemase family
CYL76_RS30040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS30100	COG0586	Pfam SNARE associated Golgi protein
CYL76_RS30105	COG1349	DNA-binding transcription factor activity
CYL76_RS30110	COG1799	cell septum assembly
CYL76_RS30130	COG2040	homocysteine
CYL76_RS30140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYL76_RS30150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYL76_RS30155	COG0531	amino acid
CYL76_RS30165	COG1024	Enoyl-CoA hydratase
CYL76_RS30185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYL76_RS30210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYL76_RS30210	COG2111	Na H antiporter
CYL76_RS30215	COG1006	Multisubunit Na H antiporter MnhC subunit
CYL76_RS30220	COG0651	ATP synthesis coupled electron transport
CYL76_RS30235	COG1320	monovalent cation:proton antiporter activity
CYL76_RS30250	COG0297	glycogen (starch) synthase activity
CYL76_RS30255	COG0489	protein tyrosine kinase activity
CYL76_RS30290	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CYL76_RS30295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYL76_RS30300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYL76_RS30355	COG3629	intracellular signal transduction
CYL76_RS30355	COG3903	Transcriptional regulator
CYL76_RS30375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYL76_RS30390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CYL76_RS30400	COG0406	alpha-ribazole phosphatase activity
CYL76_RS30410	COG1653	transport
CYL76_RS30415	COG1175	transmembrane transport
CYL76_RS30420	COG0395	ABC-type sugar transport system, permease component
CYL76_RS30425	COG1940	carbohydrate kinase activity
CYL76_RS30430	COG4213	ABC transporter substrate-binding protein
CYL76_RS30440	COG4214	carbohydrate transport
CYL76_RS30445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYL76_RS30450	COG0531	amino acid
CYL76_RS30465	COG1316	TRANSCRIPTIONal
CYL76_RS30470	COG1024	Enoyl-CoA hydratase
CYL76_RS30470	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYL76_RS30475	COG0183	Belongs to the thiolase family
CYL76_RS30500	COG0446	pyridine nucleotide-disulphide oxidoreductase
CYL76_RS30510	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CYL76_RS30515	COG3253	May function as heme-dependent peroxidase
CYL76_RS30590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYL76_RS30595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYL76_RS30710	COG1063	alcohol dehydrogenase
CYL76_RS30715	COG0156	8-amino-7-oxononanoate synthase activity
CYL76_RS30720	COG0583	DNA-binding transcription factor activity
CYL76_RS30730	COG0346	lactoylglutathione lyase activity
CYL76_RS30735	COG1072	(Pantothenic acid kinase))
CYL76_RS30810	COG1175	transmembrane transport
CYL76_RS30830	COG1404	Belongs to the peptidase S8 family
CYL76_RS30850	COG1132	(ABC) transporter
CYL76_RS30860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CYL76_RS30875	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CYL76_RS30895	COG0529	Catalyzes the synthesis of activated sulfate
CYL76_RS30900	COG0175	sulfate reduction
CYL76_RS30925	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS30945	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYL76_RS30950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CYL76_RS30955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CYL76_RS30960	COG0583	DNA-binding transcription factor activity
CYL76_RS30965	COG0183	Belongs to the thiolase family
CYL76_RS31070	COG1802	Transcriptional regulator
CYL76_RS31095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CYL76_RS31100	COG2252	PERMEase
CYL76_RS31105	COG3608	succinylglutamate desuccinylase aspartoacylase
CYL76_RS31105	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CYL76_RS31135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYL76_RS31165	COG0435	Glutathione S-transferase
CYL76_RS31180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYL76_RS31185	COG0318	PFAM AMP-dependent synthetase and ligase
CYL76_RS31230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CYL76_RS31255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYL76_RS31270	COG0753	catalase activity
CYL76_RS31275	COG2084	Dehydrogenase
CYL76_RS31280	COG3622	Belongs to the hyi family
CYL76_RS31290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CYL76_RS31300	COG0395	ABC-type sugar transport system, permease component
CYL76_RS31305	COG1175	transmembrane transport
CYL76_RS31315	COG2188	Transcriptional regulator
CYL76_RS31335	COG2351	hydroxyisourate hydrolase activity
CYL76_RS31345	COG2233	PERMEase
CYL76_RS31355	COG2233	PERMEase
CYL76_RS31400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CYL76_RS31415	COG2197	response regulator
CYL76_RS31420	COG4585	Histidine kinase
CYL76_RS31440	COG1414	Transcriptional regulator
CYL76_RS31445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYL76_RS31455	COG0656	L-ascorbic acid biosynthetic process
CYL76_RS31460	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS31505	COG0673	inositol 2-dehydrogenase activity
CYL76_RS31525	COG1129	ABC transporter
CYL76_RS31545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CYL76_RS31655	COG1126	abc transporter atp-binding protein
CYL76_RS31665	COG0765	amino acid transport
CYL76_RS31670	COG0765	amino acid transport
CYL76_RS31680	COG1376	ErfK ybiS ycfS ynhG family protein
CYL76_RS31730	COG0667	Aldo Keto reductase
CYL76_RS31740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CYL76_RS31745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYL76_RS31795	COG2838	Isocitrate dehydrogenase
CYL76_RS31805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYL76_RS31815	COG0095	Lipoate-protein ligase
CYL76_RS31820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYL76_RS31835	COG1024	Enoyl-CoA hydratase
CYL76_RS31840	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS31860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYL76_RS31875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CYL76_RS31955	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS31960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYL76_RS31965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYL76_RS31975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYL76_RS31985	COG1131	(ABC) transporter
CYL76_RS31990	COG1024	Enoyl-CoA hydratase
CYL76_RS32025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CYL76_RS32040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CYL76_RS32055	COG1929	Belongs to the glycerate kinase type-1 family
CYL76_RS32075	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYL76_RS32080	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYL76_RS32110	COG0688	phosphatidylethanolamine metabolic process
CYL76_RS32125	COG2301	Belongs to the HpcH HpaI aldolase family
CYL76_RS32130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYL76_RS32130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYL76_RS32135	COG0604	alcohol dehydrogenase
CYL76_RS32140	COG0456	acetyltransferase
CYL76_RS32185	COG0583	DNA-binding transcription factor activity
CYL76_RS32190	COG0667	Aldo Keto reductase
CYL76_RS32200	COG2362	D-Aminopeptidase
CYL76_RS32205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYL76_RS32215	COG1619	proteins homologs of microcin C7 resistance protein MccF
CYL76_RS32230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CYL76_RS32250	COG2226	methyltransferase
CYL76_RS32285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CYL76_RS32335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYL76_RS32335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYL76_RS32345	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYL76_RS32365	COG4106	trans-aconitate 2-methyltransferase activity
CYL76_RS32375	COG0656	L-ascorbic acid biosynthetic process
CYL76_RS32385	COG0583	DNA-binding transcription factor activity
CYL76_RS32400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CYL76_RS32405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYL76_RS32415	COG1129	ABC transporter
CYL76_RS32420	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYL76_RS32430	COG0673	inositol 2-dehydrogenase activity
CYL76_RS32450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYL76_RS32520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYL76_RS32530	COG1881	PFAM PEBP family protein
CYL76_RS32545	COG0589	response to stress
CYL76_RS32565	COG2208	phosphoserine phosphatase activity
CYL76_RS32565	COG2770	Histidine kinase
CYL76_RS32620	COG0569	domain protein
CYL76_RS32630	COG1131	(ABC) transporter
CYL76_RS32635	COG3559	Exporter of polyketide antibiotics
CYL76_RS32645	COG1129	ABC transporter
CYL76_RS32655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYL76_RS32660	COG1869	D-ribose catabolic process
CYL76_RS32675	COG0714	Associated with various cellular activities
CYL76_RS32710	COG0745	RESPONSE REGULATOR receiver
CYL76_RS32750	COG0517	IMP dehydrogenase activity
CYL76_RS32750	COG4175	Glycine betaine
CYL76_RS32755	COG4176	ABC-type proline glycine betaine transport system permease component
CYL76_RS32785	COG1070	Carbohydrate kinase
CYL76_RS32820	COG1846	Transcriptional regulator
CYL76_RS32850	COG1486	melibiose metabolic process
CYL76_RS32890	COG3012	SEC-C Motif Domain Protein
CYL76_RS32945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYL76_RS33025	COG1793	dna ligase
CYL76_RS33100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYL76_RS33120	COG1515	deoxyribonuclease V activity
CYL76_RS33130	COG3268	Saccharopine dehydrogenase
CYL76_RS33135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CYL76_RS33145	COG0183	Belongs to the thiolase family
CYL76_RS33155	COG0789	Transcriptional regulator
CYL76_RS33180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CYL76_RS33225	COG1024	Enoyl-CoA hydratase
CYL76_RS33240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CYL76_RS33275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYL76_RS33290	COG1388	LysM domain
CYL76_RS33290	COG1134	teichoic acid transport
CYL76_RS33305	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CYL76_RS33315	COG1657	PFAM Prenyltransferase squalene oxidase
CYL76_RS33340	COG2365	Tyrosine phosphatase family
CYL76_RS33360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYL76_RS33400	COG3467	pyridoxamine 5'-phosphate
CYL76_RS33440	COG1609	Transcriptional regulator
CYL76_RS33485	COG3958	Transketolase
CYL76_RS33490	COG3959	Transketolase, thiamine diphosphate binding domain
CYL76_RS33525	COG1215	transferase activity, transferring glycosyl groups
CYL76_RS33555	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS33570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYL76_RS33605	COG0318	PFAM AMP-dependent synthetase and ligase
CYL76_RS33625	COG3511	phospholipase C
CYL76_RS33635	COG2197	response regulator
CYL76_RS33640	COG3851	Histidine kinase
CYL76_RS33650	COG0247	lactate metabolic process
CYL76_RS33655	COG1139	Iron-sulfur cluster binding protein
CYL76_RS33660	COG1556	Lactate utilization protein
CYL76_RS33680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CYL76_RS33680	COG1672	PFAM Archaeal ATPase
CYL76_RS33730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CYL76_RS33750	COG0714	Associated with various cellular activities
CYL76_RS33820	COG0446	pyridine nucleotide-disulphide oxidoreductase
CYL76_RS33820	COG1902	pentaerythritol trinitrate reductase activity
CYL76_RS33840	COG1846	Transcriptional regulator
CYL76_RS33905	COG1233	COG1233 Phytoene dehydrogenase and related
CYL76_RS33910	COG2130	NADP-dependent
CYL76_RS33930	COG2080	2 iron, 2 sulfur cluster binding
CYL76_RS33935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CYL76_RS33940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CYL76_RS33955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CYL76_RS33980	COG0019	diaminopimelate decarboxylase activity
CYL76_RS33990	COG2837	iron assimilation
CYL76_RS34010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYL76_RS34020	COG0789	Transcriptional regulator
CYL76_RS34045	COG0596	Alpha beta hydrolase
CYL76_RS34055	COG0395	ABC-type sugar transport system, permease component
CYL76_RS34060	COG1175	transmembrane transport
CYL76_RS34080	COG1652	LysM domain
CYL76_RS34115	COG0784	Response regulator, receiver
CYL76_RS34120	COG4251	negative regulation of phosphorylation
CYL76_RS34190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYL76_RS34195	COG3275	phosphorelay sensor kinase activity
CYL76_RS34270	COG0583	DNA-binding transcription factor activity
CYL76_RS34305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYL76_RS34315	COG3360	Dodecin
CYL76_RS34335	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CYL76_RS34340	COG0121	glutamine amidotransferase
CYL76_RS34345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CYL76_RS34350	COG3572	ergothioneine biosynthetic process
CYL76_RS34365	COG1609	Transcriptional regulator
CYL76_RS34375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYL76_RS34430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYL76_RS34445	COG1834	amidinotransferase
CYL76_RS34460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYL76_RS34500	COG1028	Short-chain dehydrogenase reductase Sdr
CYL76_RS34530	COG1309	transcriptional regulator
CYL76_RS34560	COG0574	Belongs to the PEP-utilizing enzyme family
CYL76_RS34560	COG3848	Pyruvate phosphate dikinase
CYL76_RS34565	COG0574	Belongs to the PEP-utilizing enzyme family
CYL76_RS34565	COG3848	Pyruvate phosphate dikinase
CYL76_RS34580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CYL76_RS34645	COG0477	Major facilitator Superfamily
CYL76_RS34650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYL76_RS34660	COG0254	rRNA binding
CYL76_RS34665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYL76_RS34670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYL76_RS34675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYL76_RS34695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS34700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYL76_RS34705	COG1120	ATPase activity
CYL76_RS34780	COG0438	transferase activity, transferring glycosyl groups
CYL76_RS34805	COG0297	glycogen (starch) synthase activity
CYL76_RS34805	COG0438	transferase activity, transferring glycosyl groups
CYL76_RS34870	COG0517	IMP dehydrogenase activity
CYL76_RS34870	COG1125	glycine betaine transport
CYL76_RS34880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYL76_RS34900	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS34905	COG1960	acyl-CoA dehydrogenase activity
CYL76_RS34920	COG0601	transmembrane transport
CYL76_RS34925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYL76_RS34930	COG0444	Belongs to the ABC transporter superfamily
CYL76_RS34990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CYL76_RS34990	COG1796	DNA polymerase
CYL76_RS35075	COG1278	Cold shock
CYL76_RS35110	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CYL76_RS35145	COG5297	Belongs to the glycosyl hydrolase family 6
CYL76_RS35190	COG2223	nitrite transmembrane transporter activity
CYL76_RS35205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYL76_RS35245	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CYL76_RS35275	COG0745	RESPONSE REGULATOR receiver
CYL76_RS35360	COG3239	Fatty acid desaturase
CYL76_RS35395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYL76_RS35405	COG0640	Transcriptional regulator
CYL76_RS35455	COG1024	Enoyl-CoA hydratase
CYL76_RS35490	COG1595	DNA-templated transcription, initiation
CYL76_RS35510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYL76_RS35520	COG2340	Cysteine-rich secretory protein family
CYL76_RS35550	COG0488	(ABC) transporter
CYL76_RS35565	COG0009	L-threonylcarbamoyladenylate synthase
CYL76_RS35600	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CYL76_RS35635	COG0789	Transcriptional regulator
CYL76_RS35640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CYL76_RS35665	COG2890	protein-(glutamine-N5) methyltransferase activity
CYL76_RS35700	COG1175	transmembrane transport
CYL76_RS35705	COG0395	ABC-type sugar transport system, permease component
CYL76_RS35710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYL76_RS35725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYL76_RS35750	COG2367	Beta-lactamase
CYL76_RS35805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CYL76_RS35840	COG2814	Major facilitator Superfamily
CYL76_RS35845	COG1505	serine-type exopeptidase activity
CYL76_RS35880	COG1122	ATPase activity
CYL76_RS35920	COG3328	transposase activity