locus-tag class description GR131_RS00255 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GR131_RS00260 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme GR131_RS00290 ENOG4105C57 major facilitator superfamily GR131_RS00300 ENOG4105DGU Histone deacetylase GR131_RS00310 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GR131_RS00315 ENOG4105F1N DNA alkylation repair GR131_RS00320 ENOG4107EEY synthase GR131_RS00325 ENOG4107SQU synthase GR131_RS00345 ENOG4108KXM LysR family Transcriptional regulator GR131_RS00355 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GR131_RS00370 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GR131_RS00400 ENOG4105CJA serine threonine protein kinase GR131_RS00440 ENOG4105EMN RNA polymerase sigma factor GR131_RS00450 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS00460 ENOG4105EE1 crotonyl-CoA reductase GR131_RS00475 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GR131_RS00485 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GR131_RS00490 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GR131_RS00495 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GR131_RS00500 ENOG4105CHR reductase GR131_RS00505 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GR131_RS00535 ENOG4105C2J ABC transporter GR131_RS00540 ENOG4108IV0 ABC, transporter GR131_RS00545 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR131_RS00580 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GR131_RS00585 ENOG4106YKD Cytochrome p-450 GR131_RS00605 ENOG4108JA1 polyketide synthase GR131_RS00605 ENOG4108JA1 polyketide synthase GR131_RS00645 ENOG4105C0K Gdp-mannose 4,6-dehydratase GR131_RS00685 ENOG4108R85 Short chain dehydrogenase GR131_RS00690 ENOG4105C3F Signal peptidase i GR131_RS00735 ENOG4107QNK )-transporter GR131_RS00745 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GR131_RS00790 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GR131_RS00795 ENOG4105C3U ABC transporter GR131_RS00800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS00815 ENOG4105D2B acyl-CoA dehydrogenase GR131_RS00820 ENOG4105D2B acyl-CoA dehydrogenase GR131_RS00825 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GR131_RS00845 ENOG4108IJ8 ABC transporter GR131_RS00855 ENOG4105E90 ABC transporter GR131_RS00860 ENOG4105E90 ABC transporter GR131_RS00865 ENOG4106A3M Cytochrome p-450 GR131_RS00870 ENOG41065KQ synthase GR131_RS00880 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GR131_RS00905 ENOG4108JQ7 (ABC) transporter GR131_RS00915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS00945 ENOG4105FB2 class II Aldolase GR131_RS00950 ENOG4105G63 Type III effector Hrp-dependent GR131_RS00960 ENOG4105C6Z Gluconate GR131_RS00965 ENOG4105MVE transcriptional regulator GR131_RS00985 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GR131_RS00995 ENOG4105IKQ hydratase GR131_RS01000 ENOG4107HP6 Transcriptional regulator GR131_RS01025 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GR131_RS01040 ENOG4108UW5 maltose o-acetyltransferase GR131_RS01050 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GR131_RS01055 ENOG4105BZ1 (ABC) transporter GR131_RS01060 ENOG4105BZ1 (ABC) transporter GR131_RS01085 ENOG4105E0A ABC, transporter GR131_RS01090 ENOG4105S6R Iron-hydroxamate transporter permease subunit GR131_RS01095 ENOG4108U1V ABC transporter, permease GR131_RS01125 ENOG4107R7A Allophanate hydrolase subunit 2 GR131_RS01130 ENOG4105P4J Allophanate hydrolase, subunit 1 GR131_RS01135 ENOG4105E7W lamb ycsf family protein GR131_RS01165 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GR131_RS01170 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GR131_RS01185 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GR131_RS01215 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GR131_RS01220 ENOG4107Y2X deaminase GR131_RS01225 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GR131_RS01230 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GR131_RS01240 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GR131_RS01250 ENOG4105I82 acetyl xylan esterase GR131_RS01260 ENOG4105DEF Extracellular solute-binding protein, family 5 GR131_RS01265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS01270 ENOG4105C3U ABC transporter GR131_RS01275 ENOG4108JQ7 (ABC) transporter GR131_RS01280 ENOG4105DIK (ABC) transporter GR131_RS01285 ENOG4105CC5 ABC transporter GR131_RS01295 ENOG4107XSR periplasmic solute binding protein GR131_RS01305 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid GR131_RS01315 ENOG4105VMP Transcriptional regulator GR131_RS01335 ENOG4106F1P AAA ATPase, central domain protein GR131_RS01405 ENOG4105CXK mandelate racemase muconate lactonizing GR131_RS01425 ENOG41061MV Arylsulfatase GR131_RS01455 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR131_RS01485 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GR131_RS01490 ENOG4105KDC 50s ribosomal protein l28 GR131_RS01495 ENOG4105W0E 50S ribosomal protein L33 GR131_RS01500 ENOG4105NRA 50s ribosomal protein l31 type b GR131_RS01510 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GR131_RS01535 ENOG4105CVN desaturase GR131_RS01550 ENOG410829K Lysine exporter protein (Lyse ygga) GR131_RS01575 ENOG4105DCG PHP domain protein GR131_RS01585 ENOG4105EZR dyp-type peroxidase family protein GR131_RS01610 ENOG4107QN2 dihydrolipoyl dehydrogenase GR131_RS01615 ENOG41080RH Thioredoxin GR131_RS01635 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process GR131_RS01640 ENOG4108V75 Glutamine amidotransferase GR131_RS01645 ENOG41067HS methyltransferase GR131_RS01655 ENOG4105WKW Pfam:DUF1458 GR131_RS01665 ENOG4105DEN Luciferase family GR131_RS01670 ENOG4105E33 succinate dehydrogenase GR131_RS01685 ENOG4105C5Q Transcriptional regulator GR131_RS01690 ENOG4105BZU Histidine kinase GR131_RS01720 ENOG4108ZJ4 polysaccharide deacetylase GR131_RS01745 ENOG4107YPT transcriptional regulator GR131_RS01750 ENOG4108HRK Histidine kinase GR131_RS01765 ENOG4105DY9 regulatoR GR131_RS01805 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GR131_RS01810 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GR131_RS01820 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS01825 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GR131_RS01830 ENOG4108KTG Membrane protein, drug metabolite transporter GR131_RS01835 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GR131_RS01855 ENOG4105BZ1 (ABC) transporter GR131_RS01865 ENOG4108KPJ rna polymerase sigma factor GR131_RS01875 ENOG4105CV8 reductase GR131_RS01900 ENOG4105BZU Histidine kinase GR131_RS01940 ENOG4106T9R serine protease GR131_RS01945 ENOG4105D0M Protease HtpX homolog GR131_RS01960 ENOG4105D56 permease protein GR131_RS01985 ENOG4105C5X domain protein GR131_RS02005 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS02015 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GR131_RS02025 ENOG4105F1K Glutamine amidotransferase GR131_RS02030 ENOG4105CTQ phosphohexokinase GR131_RS02050 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GR131_RS02055 ENOG4105CHF Glutathione S-transferase GR131_RS02065 ENOG4105E2B Taurine dioxygenase GR131_RS02110 ENOG4105F6E Acyl-transferase GR131_RS02115 ENOG4105HHS UPF0256 protein GR131_RS02125 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GR131_RS02140 ENOG4105KI2 Urea amidohydrolase subunit beta GR131_RS02145 ENOG4108YZ9 Urea amidohydrolase subunit gamma GR131_RS02160 ENOG4107SN7 NLP P60 protein GR131_RS02185 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GR131_RS02190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GR131_RS02195 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GR131_RS02245 ENOG4108KX4 response regulator GR131_RS02260 ENOG4105DEN Luciferase family GR131_RS02265 ENOG4105DEN Luciferase family GR131_RS02275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS02320 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR131_RS02365 ENOG4105C83 adenylosuccinate lyase GR131_RS02370 ENOG4108VCA G U mismatch-specific DNA glycosylase GR131_RS02385 ENOG4105DKQ ROK family GR131_RS02390 ENOG4105FDP GntR family transcriptional regulator GR131_RS02395 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GR131_RS02430 ENOG4108PSK reductase GR131_RS02435 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GR131_RS02440 ENOG4105F7P transcriptional regulator AsnC family GR131_RS02445 ENOG4105EYH Exonuclease GR131_RS02450 ENOG4107RH8 nuclease SbcCD subunit D GR131_RS02465 ENOG4105EMN RNA polymerase sigma factor GR131_RS02485 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GR131_RS02490 ENOG4105K4P CoA-binding domain protein GR131_RS02500 ENOG4108UW5 maltose o-acetyltransferase GR131_RS02505 ENOG4108Z0R Transferase GR131_RS02560 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GR131_RS02580 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GR131_RS02590 ENOG4105CXN decarboxylase GR131_RS02610 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GR131_RS02615 ENOG4105EP9 oxidoreductase GR131_RS02640 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GR131_RS02645 ENOG4108J59 Extracellular solute-binding protein, family 5 GR131_RS02650 ENOG4105CHR reductase GR131_RS02680 ENOG4105DV0 amidase (EC 3.5.1.4 GR131_RS02690 ENOG4105BZU Histidine kinase GR131_RS02710 ENOG4108Q5Y Membrane GR131_RS02715 ENOG4105CSW GntR family transcriptional regulator GR131_RS02725 ENOG4108RNG Permease of the drug metabolite transporter GR131_RS02745 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GR131_RS02755 ENOG4105JAB phenazine biosynthesis protein, phzf family GR131_RS02785 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GR131_RS02795 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GR131_RS02815 ENOG4108UW8 fha domain-containing protein GR131_RS02865 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GR131_RS02875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR131_RS02895 ENOG4108UQS dipeptidase GR131_RS02970 ENOG4105JXB ankyrin repeat-containing protein GR131_RS02985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GR131_RS02990 ENOG4108VW9 Membrane GR131_RS03000 ENOG4105DEU major facilitator superfamily GR131_RS03005 ENOG4105Q70 GR131_RS03010 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GR131_RS03015 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GR131_RS03025 ENOG4105EW9 transcriptional regulator AsnC family GR131_RS03035 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS03065 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GR131_RS03070 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GR131_RS03075 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GR131_RS03080 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GR131_RS03100 ENOG4105ECP epimerase GR131_RS03105 ENOG4105E2R ROK family GR131_RS03120 ENOG4105C2W permease GR131_RS03125 ENOG4105FDR Membrane GR131_RS03130 ENOG4105DUM transcriptional regulator, lysR family GR131_RS03185 ENOG4105DKT Transcriptional regulator GR131_RS03190 ENOG4105DJV ribulose-phosphate 3-epimerase GR131_RS03210 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GR131_RS03225 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GR131_RS03235 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GR131_RS03250 ENOG4105SKN orotidine 5''-phosphate decarboxylase GR131_RS03255 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GR131_RS03260 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GR131_RS03265 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GR131_RS03275 ENOG4105CD3 dihydroorotase GR131_RS03280 ENOG4105CXT aspartate transcarbamylase GR131_RS03285 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GR131_RS03295 ENOG410803B Involved in the transcription termination process (By similarity) GR131_RS03300 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GR131_RS03305 ENOG4105DC7 peptidase M24 GR131_RS03315 ENOG4105D49 3-dehydroquinate synthase GR131_RS03320 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GR131_RS03325 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GR131_RS03330 ENOG4105E2X shikimate dehydrogenase GR131_RS03335 ENOG4105HHA aminodeoxychorismate lyase GR131_RS03340 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GR131_RS03345 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GR131_RS03360 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GR131_RS03375 ENOG4105CUT histidyl-tRNA synthetase GR131_RS03385 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GR131_RS03390 ENOG4105C99 atpase involved in dna repair GR131_RS03400 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GR131_RS03405 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GR131_RS03410 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GR131_RS03415 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GR131_RS03425 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GR131_RS03430 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GR131_RS03435 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GR131_RS03440 ENOG4105CDY transcriptional regulatory protein GR131_RS03445 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GR131_RS03450 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GR131_RS03460 ENOG4105E2K Glycosyl transferase (Group 1 GR131_RS03465 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GR131_RS03470 ENOG4108VTU Cdp-alcohol phosphatidyltransferase GR131_RS03485 ENOG4105EYW Ion transport protein GR131_RS03490 ENOG4105C22 threonyL-tRNA synthetase GR131_RS03525 ENOG4105KF0 sporulation and cell division protein, SsgA GR131_RS03545 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GR131_RS03555 ENOG4105CRQ synthase (Component I) GR131_RS03620 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GR131_RS03625 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GR131_RS03640 ENOG4105D01 (LipO)protein GR131_RS03645 ENOG4105D01 (LipO)protein GR131_RS03650 ENOG4108UMI ABC transporter, permease GR131_RS03655 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GR131_RS03660 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GR131_RS03685 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GR131_RS03690 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS03695 ENOG4105C57 major facilitator superfamily GR131_RS03700 ENOG4105RJZ Transcriptional regulator GR131_RS03715 ENOG4105CH7 arginosuccinase GR131_RS03725 ENOG4105C09 Bile acid GR131_RS03730 ENOG4105EYF MMPL domain protein GR131_RS03740 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS03745 ENOG4105BZU Histidine kinase GR131_RS03750 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GR131_RS03755 ENOG4105C8Y Acetylornithine aminotransferase GR131_RS03760 ENOG4105CAS nag kinase GR131_RS03765 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GR131_RS03770 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GR131_RS03785 ENOG4108Z6Z Transcriptional regulator GR131_RS03800 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GR131_RS03830 ENOG4105E9K Isocitrate dehydrogenase GR131_RS03850 ENOG4105C57 major facilitator superfamily GR131_RS03875 ENOG4105T38 integral membrane protein GR131_RS03905 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GR131_RS03910 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GR131_RS03915 ENOG4105BZU Histidine kinase GR131_RS03925 ENOG4108RWN rrna methyltransferase GR131_RS03930 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GR131_RS03935 ENOG41084BS 50S ribosomal protein L35 GR131_RS03940 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GR131_RS03950 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GR131_RS03985 ENOG4105C26 Dehydrogenase GR131_RS03990 ENOG4105C5F glutamine synthetase GR131_RS03995 ENOG41073TP transcriptional regulator GR131_RS04000 ENOG4105CUB amino acid GR131_RS04005 ENOG4108Z86 Glutamine amidotransferase GR131_RS04030 ENOG4108IJ7 Glycine betaine GR131_RS04035 ENOG4105HFS 5'-3' exonuclease GR131_RS04045 ENOG4105K6V RNA polymerase GR131_RS04050 ENOG4105RNG membrane GR131_RS04055 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GR131_RS04095 ENOG4105JZI cytochrome P450 GR131_RS04110 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GR131_RS04115 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GR131_RS04150 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GR131_RS04165 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GR131_RS04170 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GR131_RS04180 ENOG4105E5F proteasome GR131_RS04185 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GR131_RS04215 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS04220 ENOG4105DEF Extracellular solute-binding protein, family 5 GR131_RS04225 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GR131_RS04230 ENOG4105C3R Methionine synthase GR131_RS04240 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GR131_RS04245 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GR131_RS04250 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GR131_RS04265 ENOG4105C8N cysteinyl-tRNA synthetase GR131_RS04285 ENOG4105D7N magnesium and cobalt transport protein CorA GR131_RS04295 ENOG4105DYW oxidoreductase GR131_RS04300 ENOG4105CPC Aldo Keto reductase GR131_RS04330 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GR131_RS04340 ENOG4105K78 MarR family Transcriptional regulator GR131_RS04345 ENOG4105K5B UPF0225 protein GR131_RS04355 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GR131_RS04360 ENOG4105C6Z Gluconate GR131_RS04395 ENOG4105PTV Nudix Hydrolase GR131_RS04400 ENOG4105VG5 Membrane GR131_RS04405 ENOG4105JP4 Inner membrane protein yidG GR131_RS04420 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS04425 ENOG4108IG5 Transcriptional regulator GR131_RS04430 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS04455 ENOG4105EHZ conserved protein UCP016719 GR131_RS04480 ENOG4108Z4X TRANSCRIPTIONal GR131_RS04500 ENOG4108SGK Tetr family transcriptional regulator GR131_RS04520 ENOG4105F1J Homogentisate 1,2-dioxygenase GR131_RS04525 ENOG4105FDP GntR family transcriptional regulator GR131_RS04530 ENOG4105EEM helicase GR131_RS04550 ENOG4108TCJ secreted hydrolase GR131_RS04575 ENOG4105K64 Glycosyl transferase, family 2 GR131_RS04635 ENOG4107IFA Lipase (EC 3.1.1.3) GR131_RS04640 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GR131_RS04645 ENOG4105C0B DNA polymerase III (alpha subunit) GR131_RS04665 ENOG4106NMR serine protease GR131_RS04680 ENOG4105CPU Monooxygenase GR131_RS04685 ENOG4105EAB amino acid AbC transporter GR131_RS04695 ENOG4105E5Q amino acid AbC transporter GR131_RS04705 ENOG4105E5Q amino acid AbC transporter GR131_RS04720 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GR131_RS04725 ENOG4105C57 major facilitator superfamily GR131_RS04735 ENOG410841Q phosphoesterase PA-phosphatase related protein GR131_RS04755 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GR131_RS04775 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GR131_RS04785 ENOG4105CAT Cytidine monophosphate kinase GR131_RS04800 ENOG410756H nucleotidyltransferase GR131_RS04805 ENOG41065RQ ADP-ribosylation crystallin J1 GR131_RS04815 ENOG4105FE9 pseudouridine synthase GR131_RS04820 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GR131_RS04825 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GR131_RS04840 ENOG4105DCF alanine dehydrogenase GR131_RS04850 ENOG4108YZ4 nudix hydrolase GR131_RS04855 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GR131_RS04860 ENOG4105BZP glycoside hydrolase 15-related GR131_RS04895 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GR131_RS04900 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GR131_RS04920 ENOG4105DSU hydrolase GR131_RS04955 ENOG4108VX5 3-methyladenine DNA glycosylase GR131_RS04965 ENOG4108V1U phospholipid-binding protein GR131_RS04985 ENOG4105DKW ABC transporter GR131_RS05000 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS05015 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GR131_RS05025 ENOG4105IDI abc transporter atp-binding protein GR131_RS05030 ENOG4105EAC phosphoserine phosphatase GR131_RS05045 ENOG4105DJ2 Major Facilitator Superfamily GR131_RS05050 ENOG4107YCY Transcriptional regulator GR131_RS05060 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GR131_RS05070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GR131_RS05075 ENOG4105Y3U Transglycosylase-associated protein GR131_RS05095 ENOG4105CFC Transporter GR131_RS05105 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GR131_RS05110 ENOG4107QN1 sodium solute GR131_RS05125 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F GR131_RS05145 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GR131_RS05155 ENOG4105CHR reductase GR131_RS05200 ENOG4105C5H ABC transporter GR131_RS05220 ENOG4107W7X Aldolase GR131_RS05235 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GR131_RS05240 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GR131_RS05255 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GR131_RS05285 ENOG4105C5R Aminotransferase GR131_RS05290 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GR131_RS05305 ENOG4105EV8 ectoine hydroxylase GR131_RS05310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GR131_RS05340 ENOG4105BZU Histidine kinase GR131_RS05345 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS05380 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GR131_RS05390 ENOG4108UNV SUF system FeS assembly protein, NifU family GR131_RS05395 ENOG4105C9B Cysteine desulfurase GR131_RS05400 ENOG4105C3K feS assembly ATPase SufC GR131_RS05410 ENOG4105JRK feS assembly protein SufD GR131_RS05425 ENOG4105CJ1 ABC, transporter GR131_RS05450 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GR131_RS05455 ENOG4105CV1 Transketolase (EC 2.2.1.1) GR131_RS05460 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GR131_RS05475 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GR131_RS05480 ENOG4107QP8 phosphohexose isomerase GR131_RS05495 ENOG4105CP7 Triose-phosphate isomerase GR131_RS05500 ENOG4105BZA Phosphoglycerate kinase GR131_RS05505 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GR131_RS05510 ENOG4105CIE May be required for sporulation (By similarity) GR131_RS05520 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GR131_RS05525 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GR131_RS05540 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GR131_RS05550 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GR131_RS05555 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GR131_RS05575 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GR131_RS05580 ENOG4105BZU Histidine kinase GR131_RS05585 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GR131_RS05590 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GR131_RS05595 ENOG4105DXI Major Facilitator superfamily GR131_RS05645 ENOG4105CSX c4-dicarboxylate anaerobic carrier GR131_RS05675 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GR131_RS05695 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR131_RS05700 ENOG4105CQ7 ATP-dependent helicase GR131_RS05720 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) GR131_RS05725 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GR131_RS05735 ENOG4105C32 Amino acid ABC transporter (Permease) GR131_RS05740 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GR131_RS05745 ENOG4105C0Z ABC transporter GR131_RS05750 ENOG4108IV0 ABC, transporter GR131_RS05775 ENOG4105CGH 5'-nucleotidase GR131_RS05780 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GR131_RS05810 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GR131_RS05820 ENOG4105C1J atp-dependent rna helicase GR131_RS05825 ENOG4105VEQ Cold shock protein GR131_RS05840 ENOG4105CBC glutamate synthase GR131_RS05870 ENOG4108RVA ribokinase GR131_RS05875 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GR131_RS05885 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GR131_RS05895 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GR131_RS05900 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GR131_RS05905 ENOG4105DK0 Indole-3-glycerol phosphate synthase GR131_RS05935 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GR131_RS05945 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GR131_RS05950 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GR131_RS05955 ENOG4108176 endoribonuclease L-psp GR131_RS05960 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GR131_RS05965 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GR131_RS05970 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GR131_RS05975 ENOG4105CIH Imidazole acetol-phosphate transaminase GR131_RS05980 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GR131_RS06000 ENOG4108Z66 YbaK ebsC protein GR131_RS06025 ENOG4105C0B DNA polymerase III (alpha subunit) GR131_RS06045 ENOG4108UGD Serine Threonine protein kinase GR131_RS06060 ENOG41082BV acetyltransferase GR131_RS06070 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GR131_RS06075 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GR131_RS06080 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GR131_RS06090 ENOG4107VQS DivIVA family GR131_RS06100 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GR131_RS06110 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GR131_RS06115 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GR131_RS06125 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GR131_RS06135 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GR131_RS06140 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GR131_RS06150 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GR131_RS06155 ENOG4105CJN penicillin-binding protein GR131_RS06165 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GR131_RS06175 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GR131_RS06195 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GR131_RS06210 ENOG4107Z3H Transcriptional regulator, TetR family GR131_RS06230 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GR131_RS06240 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase GR131_RS06245 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GR131_RS06255 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GR131_RS06265 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GR131_RS06275 ENOG4108UQY Iron-storage protein GR131_RS06285 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GR131_RS06300 ENOG4105C5I Dehydrogenase GR131_RS06305 ENOG4108WQH regulatoR GR131_RS06310 ENOG4105ENE Histidine kinase GR131_RS06335 ENOG4105DKQ ROK family GR131_RS06345 ENOG4105D0U Arsenite-activated ATPase (ArsA) GR131_RS06365 ENOG4105JNK Glycosyl transferase (Group 1 GR131_RS06400 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GR131_RS06415 ENOG4105BZU Histidine kinase GR131_RS06420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR131_RS06430 ENOG4105BZW Glycerate kinase GR131_RS06440 ENOG4108I0Q anthranilate phosphoribosyltransferase GR131_RS06445 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GR131_RS06450 ENOG4107EUI c reductase, iron-sulfur GR131_RS06455 ENOG4107UDY cytochrome C GR131_RS06460 ENOG4105CCU oxidase (Subunit III) GR131_RS06470 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GR131_RS06475 ENOG4105MCD Part of cytochrome c oxidase, its function is GR131_RS06480 ENOG4105BZ9 Cytochrome C oxidase, subunit I GR131_RS06485 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GR131_RS06490 ENOG4105C3J Cysteine desulfurase GR131_RS06520 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GR131_RS06530 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS06565 ENOG4108YZT Adenosylcobinamide kinase GR131_RS06575 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GR131_RS06585 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GR131_RS06590 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GR131_RS06610 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GR131_RS06625 ENOG4105EMU Dehydrogenase GR131_RS06660 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GR131_RS06665 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GR131_RS06695 ENOG41064MX Tetr family transcriptional regulator GR131_RS06700 ENOG4107VXZ Hydrolase GR131_RS06710 ENOG4105CMT Dihydroxyacetone kinase GR131_RS06720 ENOG4105CSR polyphosphate kinase 2 GR131_RS06725 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GR131_RS06735 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase GR131_RS06755 ENOG41081F0 Precorrin-8x methylmutase GR131_RS06765 ENOG4105CTK cobaltochelatase, cobn subunit GR131_RS06785 ENOG4105C26 Dehydrogenase GR131_RS06795 ENOG4108222 arsenate reductase GR131_RS06810 ENOG4107R5B glutamine synthetase GR131_RS06815 ENOG4107NHD transcriptional regulator GR131_RS06840 ENOG41060BG Tetr family transcriptional regulator GR131_RS06845 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GR131_RS06865 ENOG4105CG3 alpha amylase, catalytic region GR131_RS06870 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GR131_RS06875 ENOG4105D56 permease protein GR131_RS06880 ENOG4107FKK extracellular solute-binding protein family 1 GR131_RS06885 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS06900 ENOG4105CI2 imidazolone-5-propionate hydrolase GR131_RS06905 ENOG4105CUB amino acid GR131_RS06920 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GR131_RS06965 ENOG4108QBF Transcriptional regulator GR131_RS07035 ENOG4105C5F glutamine synthetase GR131_RS07055 ENOG4107R16 Multicopper oxidase GR131_RS07060 ENOG4105C4K Nad synthetase GR131_RS07075 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GR131_RS07080 ENOG4107XZ0 Peptidase M50 GR131_RS07110 ENOG4105JAB phenazine biosynthesis protein, phzf family GR131_RS07125 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GR131_RS07130 ENOG4105EHG Permease protein GR131_RS07135 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GR131_RS07140 ENOG4106A0S GR131_RS07155 ENOG4105CIK Amidinotransferase GR131_RS07165 ENOG4105FQP Beta-lactamase GR131_RS07170 ENOG4105C2C drug resistance transporter, Bcr CflA GR131_RS07180 ENOG4105CVK Glutamate decarboxylase GR131_RS07200 ENOG4105JAB phenazine biosynthesis protein, phzf family GR131_RS07205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR131_RS07210 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR131_RS07225 ENOG4105KVH Transcriptional regulator GR131_RS07265 ENOG4107XFJ UPF0246 protein GR131_RS07270 ENOG4108UHU Aldolase GR131_RS07275 ENOG4105CVJ phosphoglycerate mutase GR131_RS07285 ENOG4105EGD dinuclear metal center protein, YbgI family GR131_RS07295 ENOG4108M15 ABC transporter GR131_RS07305 ENOG4105BZU Histidine kinase GR131_RS07310 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase GR131_RS07315 ENOG4108S01 response regulator GR131_RS07330 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS07335 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GR131_RS07365 ENOG4107QVI Methyltransferase, type 11 GR131_RS07370 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GR131_RS07390 ENOG4105BZ1 (ABC) transporter GR131_RS07495 ENOG4107T5V SNARE associated Golgi GR131_RS07510 ENOG4105DAX Pfam:DUF2983 GR131_RS07560 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GR131_RS07580 ENOG4108ZGX Histidine kinase GR131_RS07585 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS07600 ENOG4105CPC Aldo Keto reductase GR131_RS07605 ENOG4105VUF Transcriptional regulator GR131_RS07640 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GR131_RS07660 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GR131_RS07675 ENOG4108ZHJ Organic hydroperoxide resistance protein GR131_RS07680 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GR131_RS07700 ENOG4105E8G Major facilitator Superfamily GR131_RS07705 ENOG4105DFF Rod shape-determining protein mreb GR131_RS07720 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR131_RS07735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GR131_RS07750 ENOG4105CH6 catalase GR131_RS07760 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GR131_RS07785 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GR131_RS07795 ENOG4105D4T Citrate transporter GR131_RS07800 ENOG4108MRH transcriptional regulatory protein GR131_RS07815 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GR131_RS07820 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS07880 ENOG4105DXX methyltransferase GR131_RS07895 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GR131_RS07910 ENOG4105KI2 Urea amidohydrolase subunit beta GR131_RS07915 ENOG4105CQM Urea amidohydrolase subunit alpha GR131_RS07920 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GR131_RS07925 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GR131_RS07930 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GR131_RS07940 ENOG4105VF7 tolerance protein GR131_RS07955 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GR131_RS07990 ENOG4105E2R ROK family GR131_RS08020 ENOG410905P Pyridoxamine 5-phosphate GR131_RS08030 ENOG4106IPI cyclase, family GR131_RS08035 ENOG4105CM2 brancheD-chain amino acid aminotransferase GR131_RS08050 ENOG4107EPV Aminotransferase class V GR131_RS08060 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GR131_RS08105 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GR131_RS08115 ENOG4105FDK ABC transporter GR131_RS08130 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GR131_RS08135 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GR131_RS08150 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GR131_RS08155 ENOG4105D4Y metalloprotease GR131_RS08165 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GR131_RS08175 ENOG4105MSB protein, conserved in bacteria GR131_RS08185 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GR131_RS08210 ENOG4105F8D glycoside hydrolase family 4 GR131_RS08240 ENOG4105K6H D-cysteine desulfhydrase GR131_RS08260 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GR131_RS08265 ENOG4107YU2 histidine triad (hIT) protein GR131_RS08270 ENOG4107RE3 peptidase, S41 GR131_RS08280 ENOG4107QWG 2-Nitropropane dioxygenase GR131_RS08285 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GR131_RS08320 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GR131_RS08325 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GR131_RS08340 ENOG4108YYC ycei family GR131_RS08350 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GR131_RS08355 ENOG4105EPR degv family GR131_RS08365 ENOG4105C8T Leucyl-tRNA synthetase GR131_RS08390 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GR131_RS08395 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GR131_RS08405 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GR131_RS08410 ENOG4105D0M Protease HtpX homolog GR131_RS08430 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GR131_RS08440 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GR131_RS08460 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GR131_RS08465 ENOG4105K46 50S ribosomal protein l27 GR131_RS08470 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GR131_RS08475 ENOG4105C03 ribonuclease GR131_RS08500 ENOG4105CNI cell division protein FtsW GR131_RS08520 ENOG4105DFF Rod shape-determining protein mreb GR131_RS08525 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GR131_RS08535 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GR131_RS08540 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GR131_RS08550 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GR131_RS08555 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GR131_RS08560 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GR131_RS08565 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GR131_RS08585 ENOG4108TGC Acyltransferase GR131_RS08590 ENOG4107S91 Sodium hydrogen exchanger GR131_RS08615 ENOG4105C85 amino acid GR131_RS08630 ENOG4105ENX hydrolase GR131_RS08645 ENOG4105C85 amino acid GR131_RS08650 ENOG4105C85 amino acid GR131_RS08655 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GR131_RS08660 ENOG4105CVK Glutamate decarboxylase GR131_RS08665 ENOG4105MC2 DSBA oxidoreductase GR131_RS08745 ENOG4106NZI LysR family Transcriptional regulator GR131_RS08765 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 GR131_RS08780 ENOG4105D8X mechanosensitive ion channel GR131_RS08790 ENOG4105F8D glycoside hydrolase family 4 GR131_RS08820 ENOG4105CT1 (ABC) transporter GR131_RS08850 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR131_RS08855 ENOG4107SET aldo keto reductase GR131_RS08875 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GR131_RS08960 ENOG4105VHU single-stranded DNA-binding protein GR131_RS09060 ENOG4105CJ1 ABC, transporter GR131_RS09070 ENOG4105C26 Dehydrogenase GR131_RS09075 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GR131_RS09080 ENOG4105DH8 myo-inositol catabolism GR131_RS09090 ENOG4105D7K pfkb domain protein GR131_RS09125 ENOG4105C7H Helicase, RecD TraA family GR131_RS09130 ENOG4105D17 glycoside hydrolase, family 3 domain protein GR131_RS09150 ENOG41060W2 glyoxylate carboligase GR131_RS09170 ENOG4108XFF GR131_RS09200 ENOG4105C29 acyl-CoA thioesterase GR131_RS09215 ENOG4107QX3 carboxylase GR131_RS09225 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GR131_RS09230 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS09245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GR131_RS09250 ENOG4108QIU Dehydrogenase GR131_RS09270 ENOG4105VMP Transcriptional regulator GR131_RS09280 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GR131_RS09310 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GR131_RS09320 ENOG4105DUU IucA IucC family protein GR131_RS09335 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GR131_RS09350 ENOG4105ECQ AraC Family Transcriptional Regulator GR131_RS09355 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GR131_RS09380 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS09415 ENOG410804D Sensor Signal Transduction Histidine Kinase GR131_RS09420 ENOG4108RQS Two component transcriptional regulator (Winged helix family GR131_RS09445 ENOG4108ZM9 phosphoglycerate mutase GR131_RS09465 ENOG4105EM7 Selenocysteine-specific translation elongation factor GR131_RS09470 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GR131_RS09480 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GR131_RS09510 ENOG4105C3G gtp-binding protein GR131_RS09525 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GR131_RS09530 ENOG4105CUB amino acid GR131_RS09535 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GR131_RS09540 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GR131_RS09545 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GR131_RS09560 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR131_RS09580 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GR131_RS09585 ENOG4107GFK fumarate GR131_RS09595 ENOG4105C9Q fumarate hydratase class II GR131_RS09605 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GR131_RS09615 ENOG4105CH6 catalase GR131_RS09620 ENOG4105BZ4 penicillin-binding protein GR131_RS09640 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GR131_RS09650 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GR131_RS09655 ENOG4105D3R alkyl hydroperoxide reductase GR131_RS09675 ENOG4108IAB Phoh family GR131_RS09680 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GR131_RS09685 ENOG4105CPC Aldo Keto reductase GR131_RS09730 ENOG4105CV8 reductase GR131_RS09735 ENOG4105F27 Major Facilitator GR131_RS09740 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR131_RS09775 ENOG4105BZU Histidine kinase GR131_RS09835 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GR131_RS09935 ENOG4105KME endoribonuclease L-psp GR131_RS09940 ENOG4108FUF Transcriptional regulator, IclR family GR131_RS09965 ENOG4106T9R serine protease GR131_RS09985 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GR131_RS10005 ENOG4105C7Z Conserved Protein GR131_RS10015 ENOG410826E Dna repair protein radc GR131_RS10100 ENOG4105T1M mycothiol conjugate amidase mca GR131_RS10110 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GR131_RS10125 ENOG4105C7B Threonine dehydratase GR131_RS10130 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GR131_RS10155 ENOG4105DQ4 alcohol dehydrogenase GR131_RS10160 ENOG4105C19 ABC transporter GR131_RS10180 ENOG4105C84 Histidine ammonia-lyase GR131_RS10185 ENOG4105KDM Diguanylate cyclase with gaf sensor GR131_RS10190 ENOG4105E39 Enoyl-CoA hydratase GR131_RS10195 ENOG4108QER Adenylate cyclase GR131_RS10205 ENOG4105D8K carboxyl transferase GR131_RS10215 ENOG4107WR6 Maf-like protein GR131_RS10225 ENOG4108JIK carboxylase GR131_RS10265 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GR131_RS10285 ENOG4105C26 Dehydrogenase GR131_RS10330 ENOG4105NAF rna polymerase sigma factor GR131_RS10335 ENOG4108KXV response regulator GR131_RS10340 ENOG41065SU Two-component system sensor kinase GR131_RS10365 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GR131_RS10390 ENOG4107RSM transcriptional regulator GR131_RS10395 ENOG4105D94 Major Facilitator Superfamily GR131_RS10405 ENOG4105BZU Histidine kinase GR131_RS10440 ENOG4105UIB (ABC) transporter GR131_RS10445 ENOG4108JQ9 ABC transporter GR131_RS10450 ENOG4105DIH basic membrane GR131_RS10480 ENOG4105E6M Sulphatase-modifying factor protein GR131_RS10495 ENOG4107RM1 amidohydrolase GR131_RS10510 ENOG4105F0R Cytidylyltransferase GR131_RS10520 ENOG4105K64 Glycosyl transferase, family 2 GR131_RS10530 ENOG4108NIW Leucine export protein LeuE GR131_RS10590 ENOG4108MMM RNA Polymerase GR131_RS10625 ENOG4105E2D ec 3.2.1.52 GR131_RS10645 ENOG4108J01 L-aspartate oxidase GR131_RS10665 ENOG41067SE Tetr family transcriptional regulator GR131_RS10685 ENOG4107RN3 metallophosphoesterase GR131_RS10700 ENOG4107H3J ribonuclease GR131_RS10745 ENOG4105C31 Tryptophanyl-tRNA synthetase GR131_RS10760 ENOG4108TM9 integral membrane protein GR131_RS10775 ENOG4105C8Y Acetylornithine aminotransferase GR131_RS10785 ENOG4106032 Glutathionylspermidine synthase GR131_RS10795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GR131_RS10800 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GR131_RS10810 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS10815 ENOG4108ME1 Peptidase M55 D-aminopeptidase GR131_RS10835 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GR131_RS10840 ENOG4105DRS transport system, permease GR131_RS10855 ENOG4107XDR Lactoylglutathione lyase GR131_RS10865 ENOG4108HQS Glycine betaine GR131_RS10870 ENOG4108IJ7 Glycine betaine GR131_RS10880 ENOG4105C26 Dehydrogenase GR131_RS10900 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GR131_RS10935 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GR131_RS10945 ENOG4105DC1 bifunctional purine biosynthesis protein purh GR131_RS10975 ENOG4105CMV Succinyl-CoA synthetase subunit beta GR131_RS10980 ENOG4105DEG Vwa containing coxe family protein GR131_RS10985 ENOG4105RD5 GR131_RS10990 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GR131_RS11010 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold GR131_RS11015 ENOG4105E4C Lytic transglycosylase catalytic GR131_RS11020 ENOG4105CSV Glutaminase GR131_RS11060 ENOG4105K4H Nlp p60 protein GR131_RS11080 ENOG4105CI2 imidazolone-5-propionate hydrolase GR131_RS11090 ENOG410645S MarR family Transcriptional regulator GR131_RS11135 ENOG4105C94 Transporter GR131_RS11140 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS11180 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GR131_RS11190 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GR131_RS11210 ENOG4105C26 Dehydrogenase GR131_RS11255 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GR131_RS11260 ENOG4107QQG Dehydrogenase GR131_RS11265 ENOG4107QVP Dehydrogenase GR131_RS11275 ENOG4108MMM RNA Polymerase GR131_RS11280 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS11285 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR131_RS11290 ENOG4105DND Transcriptional regulator GR131_RS11295 ENOG4105EMU Dehydrogenase GR131_RS11345 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GR131_RS11370 ENOG4108097 ATP-binding protein GR131_RS11375 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GR131_RS11380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GR131_RS11445 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GR131_RS11460 ENOG4105ECQ AraC Family Transcriptional Regulator GR131_RS11475 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GR131_RS11490 ENOG4105CS9 pantothenic acid kinase GR131_RS11495 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GR131_RS11500 ENOG4108UJD 30S ribosomal protein S9 GR131_RS11505 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GR131_RS11515 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GR131_RS11520 ENOG4108ZT0 50S ribosomal protein l17 GR131_RS11530 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GR131_RS11535 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GR131_RS11540 ENOG41067V7 50S ribosomal protein L36 GR131_RS11545 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GR131_RS11555 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GR131_RS11560 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GR131_RS11565 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GR131_RS11570 ENOG410849U 50S ribosomal protein L30 GR131_RS11575 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GR131_RS11580 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GR131_RS11585 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GR131_RS11590 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GR131_RS11600 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GR131_RS11605 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GR131_RS11610 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GR131_RS11615 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GR131_RS11620 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GR131_RS11625 ENOG41082SA 50s ribosomal protein l29 GR131_RS11630 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GR131_RS11635 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GR131_RS11640 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GR131_RS11645 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GR131_RS11650 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GR131_RS11655 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GR131_RS11660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GR131_RS11665 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GR131_RS11670 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GR131_RS11680 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GR131_RS11700 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GR131_RS11705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GR131_RS11710 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GR131_RS11745 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GR131_RS11750 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GR131_RS11755 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GR131_RS11760 ENOG4108VZM 50s ribosomal protein L10 GR131_RS11765 ENOG4105QCJ Lipoprotein GR131_RS11780 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GR131_RS11810 ENOG4107R4N Cell wall formation (By similarity) GR131_RS11820 ENOG410900P UPF0336 protein GR131_RS11825 ENOG4105WDJ 50S ribosomal protein L33 GR131_RS11840 ENOG4105DZC cytosine deaminase GR131_RS11860 ENOG4108VPT UPF0234 protein GR131_RS11865 ENOG4105Y3U Transglycosylase-associated protein GR131_RS11870 ENOG410901E Membrane GR131_RS11875 ENOG4105D0M Protease HtpX homolog GR131_RS11880 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS11885 ENOG4105C8S subunit m GR131_RS11890 ENOG4105D65 subunit l GR131_RS11895 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS11900 ENOG4107YX3 NADH dehydrogenase subunit j GR131_RS11905 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS11910 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GR131_RS11915 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GR131_RS11920 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS11925 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GR131_RS11940 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS11945 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GR131_RS11950 ENOG4105DQU oxidoreductase, subunit beta GR131_RS11955 ENOG4105KVH Transcriptional regulator GR131_RS11960 ENOG4105ECR NmrA family GR131_RS11995 ENOG4105DUX Transporter GR131_RS12020 ENOG410667J hydrolase GR131_RS12035 ENOG4105C9U ATP-dependent DNA helicase RecQ GR131_RS12040 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS12050 ENOG4105D65 subunit l GR131_RS12055 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS12060 ENOG41087XN oxidoreductase GR131_RS12065 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS12070 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GR131_RS12075 ENOG4108IEH NADH dehydrogenase subunit g GR131_RS12080 ENOG4107QIZ NADH dehydrogenase GR131_RS12090 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS12095 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GR131_RS12100 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS12125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR131_RS12135 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GR131_RS12185 ENOG4108EHY type IV secretion system GR131_RS12285 ENOG4105EC2 ftsk spoIIIe GR131_RS12290 ENOG4105EV6 Pfam:DUF178 GR131_RS12295 ENOG4105VEQ Cold shock protein GR131_RS12305 ENOG4105CHU acetyl-coa acetyltransferase GR131_RS12310 ENOG4105CHR reductase GR131_RS12335 ENOG4105DIM ABC transporter GR131_RS12340 ENOG4105CIG ABC transporter GR131_RS12355 ENOG4105CK2 sodium dicarboxylate symporter GR131_RS12370 ENOG4105DVY radical SAM domain protein GR131_RS12380 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GR131_RS12385 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GR131_RS12390 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GR131_RS12405 ENOG4105CRE cytochrome C GR131_RS12415 ENOG4107QIV Cytochrome c biogenesis protein GR131_RS12420 ENOG4107ZT5 Thiol disulfide interchange protein GR131_RS12430 ENOG4108RH7 phosphoglycerate mutase GR131_RS12435 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GR131_RS12455 ENOG4108UZX fmn reductase GR131_RS12485 ENOG4105CHH sulfate transporter GR131_RS12490 ENOG4105E0Y RtcB Protein GR131_RS12515 ENOG4105DK7 lysyl-tRNA synthetase GR131_RS12520 ENOG4105C75 arginyL-tRNA synthetase GR131_RS12525 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GR131_RS12545 ENOG4105D52 delta-aminolevulinic acid dehydratase GR131_RS12550 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GR131_RS12555 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GR131_RS12560 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GR131_RS12565 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GR131_RS12575 ENOG4108RXW HAD-superfamily subfamily IB hydrolase GR131_RS12590 ENOG4105HHS UPF0256 protein GR131_RS12620 ENOG4105DGU Histone deacetylase GR131_RS12650 ENOG4105C31 Tryptophanyl-tRNA synthetase GR131_RS12655 ENOG4105II7 pyrroline-5-carboxylate reductase GR131_RS12665 ENOG4105CJ1 ABC, transporter GR131_RS12685 ENOG410825M Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GR131_RS12695 ENOG4105C01 Dihydroxy-acid dehydratase GR131_RS12700 ENOG4105PF9 Transcriptional regulator GR131_RS12705 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GR131_RS12715 ENOG4107R33 ppx gppa phosphatase GR131_RS12720 ENOG4108JWX GR131_RS12750 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GR131_RS12760 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GR131_RS12770 ENOG4105NAF rna polymerase sigma factor GR131_RS12775 ENOG41075QH Lipoprotein CseA GR131_RS12780 ENOG4108PYU two-component system response regulator GR131_RS12785 ENOG4108FKE two-component system sensor kinase GR131_RS12790 ENOG4105DR5 peptidase GR131_RS12800 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GR131_RS12835 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GR131_RS12845 ENOG4108IYU L-aspartate oxidase GR131_RS12850 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GR131_RS12865 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS12880 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS12905 ENOG4105BZU Histidine kinase GR131_RS12920 ENOG4108EKI Dehydrogenase GR131_RS12960 ENOG41066YJ Beta-lactamase GR131_RS13000 ENOG4105C57 major facilitator superfamily GR131_RS13010 ENOG4108HQR Glycine betaine GR131_RS13015 ENOG4105E90 ABC transporter GR131_RS13020 ENOG4105E90 ABC transporter GR131_RS13025 ENOG4108IJ8 ABC transporter GR131_RS13045 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GR131_RS13055 ENOG4105EUJ GTP cyclohydrolase i GR131_RS13070 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GR131_RS13085 ENOG4105F0N pyrophosphate phospho-hydrolase GR131_RS13095 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN GR131_RS13100 ENOG4107TXC Transcriptional regulator GR131_RS13105 ENOG4105CS1 NAD(P)H quinone oxidoreductase GR131_RS13120 ENOG4105C26 Dehydrogenase GR131_RS13145 ENOG4105EM2 membrane GR131_RS13185 ENOG4105C2M dna polymerase I GR131_RS13190 ENOG4105D0M Protease HtpX homolog GR131_RS13210 ENOG4105C57 major facilitator superfamily GR131_RS13220 ENOG4108QBF Transcriptional regulator GR131_RS13230 ENOG4105KHM amidohydrolase 2 GR131_RS13240 ENOG4105GAK amidohydrolase 2 GR131_RS13260 ENOG4105DR5 peptidase GR131_RS13290 ENOG4105CMD Transcriptional regulator, GntR family GR131_RS13295 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GR131_RS13315 ENOG4108YZJ Pfam:DUF2596 GR131_RS13320 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GR131_RS13330 ENOG4105K4H Nlp p60 protein GR131_RS13375 ENOG4105DXX methyltransferase GR131_RS13490 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GR131_RS13495 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GR131_RS13500 ENOG41090R7 Ferric uptake GR131_RS13505 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GR131_RS13540 ENOG4105PKJ carbohydrate binding GR131_RS13545 ENOG4105KHC sulfurtransferase GR131_RS13570 ENOG4107NHD transcriptional regulator GR131_RS13575 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS13580 ENOG4105C0H protease GR131_RS13585 ENOG4105ETX regulatoR GR131_RS13600 ENOG4108HWW ABC transporter GR131_RS13605 ENOG4105C2J ABC transporter GR131_RS13615 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS13620 ENOG4108HK0 -acetyltransferase GR131_RS13645 ENOG4105EF1 ribulokinase GR131_RS13650 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GR131_RS13655 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GR131_RS13660 ENOG4105CGH 5'-nucleotidase GR131_RS13665 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GR131_RS13730 ENOG4105CHP RNA polymerase GR131_RS13735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GR131_RS13745 ENOG4108IJ6 ABC transporter GR131_RS13760 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GR131_RS13795 ENOG4108MUZ hydrolase GR131_RS13830 ENOG4108R0M Aminoglycoside GR131_RS13850 ENOG4105NAF rna polymerase sigma factor GR131_RS13875 ENOG4108RWP Major Facilitator Superfamily protein GR131_RS13905 ENOG4105EBM Alpha Beta Hydrolase Fold protein GR131_RS13960 ENOG4107R37 Glutamate dehydrogenase GR131_RS14010 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GR131_RS14015 ENOG4105CJ3 phosphate transporter GR131_RS14025 ENOG4105VPX protein, conserved in bacteria GR131_RS14035 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GR131_RS14045 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GR131_RS14050 ENOG4105E4C Lytic transglycosylase catalytic GR131_RS14080 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GR131_RS14105 ENOG4106JUT Streptomycin 3''-adenylyltransferase GR131_RS14140 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GR131_RS14145 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GR131_RS14190 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GR131_RS14205 ENOG4105CHJ isochorismatase hydrolase GR131_RS14215 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS14220 ENOG4105BZU Histidine kinase GR131_RS14235 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GR131_RS14265 ENOG4107RCW fructose-bisphosphate aldolase GR131_RS14270 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GR131_RS14285 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GR131_RS14315 ENOG4105D29 Helix-turn-helix type 11 domain protein GR131_RS14330 ENOG4105CSH Transporter GR131_RS14355 ENOG4105KNI merR family transcriptional Regulator GR131_RS14360 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GR131_RS14365 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GR131_RS14370 ENOG4105CFG Acts as a chaperone (By similarity) GR131_RS14395 ENOG4105K59 histidine triad (HIT) protein GR131_RS14405 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GR131_RS14410 ENOG4108M15 ABC transporter GR131_RS14420 ENOG4107R9S Malate synthase GR131_RS14440 ENOG4108HUF Transporter GR131_RS14450 ENOG4105E0A ABC, transporter GR131_RS14455 ENOG4105TVJ transport system, permease GR131_RS14460 ENOG4105DQ5 transport system permease protein GR131_RS14475 ENOG4105KWG Pfam:DUF1696 GR131_RS14495 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS14495 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS14535 ENOG4105F27 Major Facilitator GR131_RS14585 ENOG4105DHP deoxycytidine triphosphate deaminase GR131_RS14615 ENOG4105DF6 Fe-S oxidoreductase GR131_RS14665 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GR131_RS14700 ENOG4105DQ4 alcohol dehydrogenase GR131_RS14705 ENOG4105XTG Pfam:DUF156 GR131_RS14710 ENOG4105DZ6 Band 7 protein GR131_RS14725 ENOG4108KGH TRANSCRIPTIONal GR131_RS14765 ENOG41068WN GR131_RS14775 ENOG4105C9M aspartyl-trna synthetase GR131_RS14785 ENOG4105C02 permease GR131_RS14790 ENOG4105EUB pirin domain protein GR131_RS14800 ENOG4105CSU acyl-Coa dehydrogenase GR131_RS14810 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GR131_RS14820 ENOG4105DFM M18 family aminopeptidase GR131_RS14875 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GR131_RS14880 ENOG4105CPP Dehydrogenase, E1 component GR131_RS14900 ENOG4107QPV Serine Threonine protein kinase GR131_RS14925 ENOG4107SVH Potassium channel protein GR131_RS14930 ENOG4105CVM Molybdenum cofactor synthesis domain protein GR131_RS14940 ENOG4107QSN dihydrolipoamide acetyltransferase GR131_RS15000 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GR131_RS15010 ENOG4105TV9 FHA Domain-Containing protein GR131_RS15015 ENOG4105HZM Fha domain containing protein GR131_RS15040 ENOG4108RN7 integral membrane protein GR131_RS15045 ENOG4108U4N (sortase) family GR131_RS15065 ENOG4105ZJT Cell division protein CrgA GR131_RS15090 ENOG4108Q5F Tetr family transcriptional regulator GR131_RS15105 ENOG4108UGD Serine Threonine protein kinase GR131_RS15145 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GR131_RS15150 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GR131_RS15155 ENOG4105K7N UPF0232 protein GR131_RS15160 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GR131_RS15165 ENOG4108J5G 6-phosphogluconate dehydrogenase GR131_RS15170 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GR131_RS15175 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GR131_RS15180 ENOG41084CH 50S ribosomal protein l34 GR131_RS15185 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GR131_RS15190 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GR131_RS15195 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GR131_RS15205 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GR131_RS15210 ENOG4107QJE Chromosome Partitioning Protein GR131_RS15225 ENOG4105K63 Thioredoxin GR131_RS15230 ENOG4105C3M thioredoxin reductase GR131_RS15245 ENOG4105D9P serine threonine protein kinase GR131_RS15260 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GR131_RS15285 ENOG4105BZ4 penicillin-binding protein GR131_RS15310 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GR131_RS15315 ENOG4107YH6 single-stranded DNA-binding protein GR131_RS15320 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GR131_RS15325 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GR131_RS15335 ENOG4105CDU Replicative dna helicase GR131_RS15340 ENOG4105NAE bifunctional deaminase-reductase domain protein GR131_RS15345 ENOG4108UW5 maltose o-acetyltransferase GR131_RS15370 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) GR131_RS15390 ENOG4105C28 cystathionine GR131_RS15395 ENOG41082T9 Membrane GR131_RS15400 ENOG4106048 Cupin 2, conserved barrel domain protein GR131_RS15415 ENOG4105KF0 sporulation and cell division protein, SsgA GR131_RS15425 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GR131_RS15440 ENOG4107P2S Transcriptional regulator GR131_RS15445 ENOG4105CIH Imidazole acetol-phosphate transaminase GR131_RS15450 ENOG4105C4M (Ubiquinol oxidase) subunit I GR131_RS15455 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GR131_RS15460 ENOG4108JJ9 ABC, transporter GR131_RS15470 ENOG4105E4C Lytic transglycosylase catalytic GR131_RS15475 ENOG410667J hydrolase GR131_RS15495 ENOG4105DA5 (ABC) transporter GR131_RS15515 ENOG410667J hydrolase GR131_RS15520 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GR131_RS15525 ENOG4105CQC Prephenate dehydratase GR131_RS15530 ENOG4105DBE peroxidase GR131_RS15565 ENOG4107T6F Xaa-Pro aminopeptidase GR131_RS15580 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GR131_RS15595 ENOG4105C0H protease GR131_RS15615 ENOG4105NAF rna polymerase sigma factor GR131_RS15620 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS15625 ENOG4108UXN response regulator GR131_RS15645 ENOG4105VTR Integrase GR131_RS15685 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GR131_RS15725 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GR131_RS15730 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GR131_RS15735 ENOG4107XZC Restriction modification system DNA (Specificity GR131_RS15740 ENOG4105CVR type I restriction-modification system GR131_RS15760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR131_RS15770 ENOG4105C57 major facilitator superfamily GR131_RS15790 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR131_RS15795 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GR131_RS15805 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS15810 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS15825 ENOG4108Z6B deaminase GR131_RS15840 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GR131_RS15865 ENOG4105CHR reductase GR131_RS15900 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GR131_RS15905 ENOG4105EZR dyp-type peroxidase family protein GR131_RS15915 ENOG4105CHH sulfate transporter GR131_RS15940 ENOG4105C12 Phosphoribosylglycinamide synthetase GR131_RS15955 ENOG4105C8V SAICAR synthetase GR131_RS16000 ENOG410839H phosphoribosylformylglycinamidine synthase GR131_RS16005 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GR131_RS16010 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GR131_RS16025 ENOG4105CXB phosphoribosylaminoimidazole synthetase GR131_RS16045 ENOG4108TAC GR131_RS16065 ENOG4105CQ7 ATP-dependent helicase GR131_RS16100 ENOG4105C1J atp-dependent rna helicase GR131_RS16115 ENOG4105KDP XRE family GR131_RS16335 ENOG4105CFI type iii restriction protein res subunit GR131_RS16425 ENOG4105CPC Aldo Keto reductase GR131_RS16435 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GR131_RS16440 ENOG4105D5U fad dependent oxidoreductase GR131_RS16455 ENOG4105ESP cell wall surface anchor family protein GR131_RS16540 ENOG4105CVA phosphate GR131_RS16600 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS16615 ENOG4107SNB ankyrin repeat protein YahD GR131_RS16620 ENOG4105KME endoribonuclease L-psp GR131_RS16625 ENOG4105KVH Transcriptional regulator GR131_RS16665 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GR131_RS16685 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GR131_RS16690 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GR131_RS16705 ENOG4105CFH Aspartokinase GR131_RS16735 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GR131_RS16750 ENOG4105D9P serine threonine protein kinase GR131_RS16810 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS16825 ENOG4105NI8 Cytosine-specific methyltransferase GR131_RS16845 ENOG4105BZ4 penicillin-binding protein GR131_RS16865 ENOG4105KME endoribonuclease L-psp GR131_RS16875 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GR131_RS16890 ENOG4105P8F nudix hydrolase GR131_RS16905 ENOG4105D74 hydrolase GR131_RS16915 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GR131_RS16920 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR131_RS16925 ENOG4105CHH sulfate transporter GR131_RS16985 ENOG4108I5C dEAD DEAH box helicase GR131_RS16990 ENOG4105WN5 stage II sporulation protein GR131_RS17005 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR131_RS17015 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GR131_RS17020 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GR131_RS17050 ENOG4108Z6Z Transcriptional regulator GR131_RS17065 ENOG4105C5I Dehydrogenase GR131_RS17070 ENOG4105JSC dimethylmenaquinone methyltransferase GR131_RS17085 ENOG4105W1Y Transcriptional regulator GR131_RS17095 ENOG4105D8K carboxyl transferase GR131_RS17100 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS17110 ENOG4105C6F GntR Family Transcriptional Regulator GR131_RS17150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GR131_RS17200 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GR131_RS17205 ENOG4105CEP NADH dehydrogenase GR131_RS17215 ENOG41082SX arsR family transcriptional regulator GR131_RS17225 ENOG4107TB5 TRANSCRIPTIONal GR131_RS17230 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GR131_RS17245 ENOG4105CN1 protease GR131_RS17250 ENOG4105CGP Urocanate hydratase GR131_RS17285 ENOG4105EHG Permease protein GR131_RS17290 ENOG4105E0A ABC, transporter GR131_RS17295 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GR131_RS17330 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GR131_RS17335 ENOG4107UJ9 cyclopropane-fatty-acyl-phospholipid synthase GR131_RS17355 ENOG4108QER Adenylate cyclase GR131_RS17395 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GR131_RS17475 ENOG410814C multidrug resistance protein GR131_RS17485 ENOG4105BZU Histidine kinase GR131_RS17490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR131_RS17505 ENOG4108VJ1 Transcriptional regulator (CarD family GR131_RS17510 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GR131_RS17515 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GR131_RS17535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS17550 ENOG4105C8N cysteinyl-tRNA synthetase GR131_RS17555 ENOG4105C2N RNA methyltransferase TrmH family group 3 GR131_RS17565 ENOG4105C37 (CBS) domain GR131_RS17575 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GR131_RS17585 ENOG4108IJ9 (ABC) transporter GR131_RS17595 ENOG4107RDB Major Facilitator GR131_RS17630 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GR131_RS17640 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GR131_RS17660 ENOG4108JPW Aminotransferase GR131_RS17665 ENOG4107YPT transcriptional regulator GR131_RS17670 ENOG4105CHM Aminotransferase GR131_RS17680 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GR131_RS17690 ENOG4107B2H carbonic anhydrase GR131_RS17745 ENOG4105VEQ Cold shock protein GR131_RS17750 ENOG4105C1J atp-dependent rna helicase GR131_RS17770 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GR131_RS17790 ENOG41083YR Protein CrcB homolog GR131_RS17795 ENOG41083TI Protein CrcB homolog GR131_RS17800 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS17805 ENOG4105ENE Histidine kinase GR131_RS17840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GR131_RS17850 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GR131_RS17855 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR131_RS17870 ENOG4105BZU Histidine kinase GR131_RS17880 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GR131_RS17885 ENOG4105FUA antagonist GR131_RS17890 ENOG4107MMM Anti-sigma-factor antagonist GR131_RS17965 ENOG4105CMR udp-glucose 4-epimerase GR131_RS18035 ENOG4105CJP fad dependent oxidoreductase GR131_RS18095 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GR131_RS18105 ENOG4105BZU Histidine kinase GR131_RS18120 ENOG4106VEM tagatose-6-phosphate kinase GR131_RS18135 ENOG4105CE4 GlcNAc 6-P deacetylase GR131_RS18155 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GR131_RS18180 ENOG4105C3Q Glycosyl transferase, family 2 GR131_RS18200 ENOG4105VEQ Cold shock protein GR131_RS18240 ENOG4107S5I aldo keto reductase GR131_RS18245 ENOG4105C5Y PTS System GR131_RS18250 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GR131_RS18255 ENOG4105QEK Transcriptional regulator GR131_RS18265 ENOG4105CVJ phosphoglycerate mutase GR131_RS18300 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS18330 ENOG4106N3A copper homeostasis protein cutc GR131_RS18350 ENOG4105EEM helicase GR131_RS18385 ENOG4105VUF Transcriptional regulator GR131_RS18390 ENOG4105CPC Aldo Keto reductase GR131_RS18425 ENOG4105CFI type iii restriction protein res subunit GR131_RS18475 ENOG4106A3M Cytochrome p-450 GR131_RS18485 ENOG4107U9T Pfam:Ribonuclease_BN GR131_RS18495 ENOG4105DQ5 transport system permease protein GR131_RS18500 ENOG4105TVJ transport system, permease GR131_RS18505 ENOG4105E0A ABC, transporter GR131_RS18510 ENOG4108HUF Transporter GR131_RS18515 ENOG4105CJA serine threonine protein kinase GR131_RS18545 ENOG4105VEQ Cold shock protein GR131_RS18550 ENOG4105E63 Pfam:DUF178 GR131_RS18555 ENOG4108UIH futalosine nucleosidase GR131_RS18565 ENOG4108N0W Major Facilitator superfamily GR131_RS18590 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GR131_RS18600 ENOG4105C7N Xanthine uracil vitamin C permease GR131_RS18625 ENOG4105CPC Aldo Keto reductase GR131_RS18705 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GR131_RS18715 ENOG4106A3M Cytochrome p-450 GR131_RS18735 ENOG4108TQ9 Histidine kinase GR131_RS18740 ENOG4105CQB FAD linked oxidase domain protein GR131_RS18750 ENOG4106NZI LysR family Transcriptional regulator GR131_RS18805 ENOG4107QX3 carboxylase GR131_RS18820 ENOG4108UKI Enoyl-CoA hydratase GR131_RS18845 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GR131_RS18855 ENOG4108SU4 UPF0309 protein GR131_RS18940 ENOG4105WN5 stage II sporulation protein GR131_RS18960 ENOG4105DCM major facilitator superfamily GR131_RS18965 ENOG4105H3G oxidoreductase GR131_RS18985 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GR131_RS18990 ENOG4108762 serine threonine protein kinase GR131_RS19010 ENOG4105F0K SARP family transcriptional regulator GR131_RS19025 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GR131_RS19055 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GR131_RS19085 ENOG41065HY 1,4-beta-cellobiosidase GR131_RS19170 ENOG4105VEQ Cold shock protein GR131_RS19185 ENOG4108KXH Ybak prolyl-tRNA synthetase associated GR131_RS19200 ENOG4108J9M Transporter GR131_RS19220 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GR131_RS19225 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GR131_RS19230 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GR131_RS19235 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GR131_RS19240 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GR131_RS19245 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR131_RS19250 ENOG4105E39 Enoyl-CoA hydratase GR131_RS19255 ENOG4105CHU acetyl-coa acetyltransferase GR131_RS19265 ENOG4108ZJI phenylacetic acid degradation protein GR131_RS19270 ENOG4105DZS Phenylacetate-CoA ligase GR131_RS19325 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GR131_RS19345 ENOG4105KXX peptidase s58 dmpa GR131_RS19360 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GR131_RS19370 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GR131_RS19385 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GR131_RS19395 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GR131_RS19400 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GR131_RS19410 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GR131_RS19415 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GR131_RS19455 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS19465 ENOG4106JDR secreted GR131_RS19475 ENOG4105F2Z 3-oxoadipate enol-lactonase GR131_RS19485 ENOG4105CGK Exodeoxyribonuclease III GR131_RS19495 ENOG4105F95 Monooxygenase GR131_RS19505 ENOG4105EMU Dehydrogenase GR131_RS19525 ENOG4105EYF MMPL domain protein GR131_RS19600 ENOG4105F8V Hydrolase, tatD family GR131_RS19605 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GR131_RS19610 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GR131_RS19615 ENOG4105C5H ABC transporter GR131_RS19660 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GR131_RS19665 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS19670 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GR131_RS19675 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GR131_RS19685 ENOG4108IG5 Transcriptional regulator GR131_RS19695 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GR131_RS19705 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GR131_RS19710 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GR131_RS19735 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GR131_RS19740 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GR131_RS19750 ENOG4105BZU Histidine kinase GR131_RS19775 ENOG4107TXC Transcriptional regulator GR131_RS19790 ENOG4105CHR reductase GR131_RS19795 ENOG4108KGH TRANSCRIPTIONal GR131_RS19805 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) GR131_RS19835 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR131_RS19900 ENOG4105CH2 amidohydrolase GR131_RS19910 ENOG4105W1N transcriptional regulator GR131_RS19915 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GR131_RS19955 ENOG4105KVH Transcriptional regulator GR131_RS19995 ENOG4106A3M Cytochrome p-450 GR131_RS20010 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GR131_RS20040 ENOG4105CEP NADH dehydrogenase GR131_RS20045 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GR131_RS20050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR131_RS20055 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR131_RS20065 ENOG4105RHY Pfam:UPF0157 GR131_RS20080 ENOG4105VZ8 Transcriptional regulator GR131_RS20100 ENOG4105CHU acetyl-coa acetyltransferase GR131_RS20150 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS20165 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GR131_RS20195 ENOG4105CI2 imidazolone-5-propionate hydrolase GR131_RS20200 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS20215 ENOG4105DUX Transporter GR131_RS20220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR131_RS20225 ENOG41065SU Two-component system sensor kinase GR131_RS20240 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GR131_RS20275 ENOG4105C6Y Udp-glucose 6-dehydrogenase GR131_RS20305 ENOG4105CH6 catalase GR131_RS20355 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GR131_RS20360 ENOG4108KGH TRANSCRIPTIONal GR131_RS20380 ENOG4108KGH TRANSCRIPTIONal GR131_RS20400 ENOG4107V9E glucose-1-phosphate thymidylyltransferase GR131_RS20410 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) GR131_RS20415 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase GR131_RS20425 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR131_RS20430 ENOG4106BQ7 Glycosyl Transferase GR131_RS20450 ENOG4105DAA L-lactate GR131_RS20460 ENOG4107QKV phosphomannomutase GR131_RS20470 ENOG4105W49 UPF0434 protein GR131_RS20480 ENOG4105EIP mannose-6-phosphate isomerase GR131_RS20490 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GR131_RS20530 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GR131_RS20535 ENOG4108WQ6 secreted protein GR131_RS20550 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GR131_RS20555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR131_RS20560 ENOG4105BZU Histidine kinase GR131_RS20565 ENOG4105G3P Lipoprotein lpqB GR131_RS20575 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GR131_RS20580 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS20585 ENOG4105T0Z Conserved Protein GR131_RS20595 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GR131_RS20610 ENOG4106NZI LysR family Transcriptional regulator GR131_RS20630 ENOG4105C7I Dehydrogenase GR131_RS20645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR131_RS20655 ENOG4107SJB teichoic acid biosynthesis GR131_RS20660 ENOG4107SJB teichoic acid biosynthesis GR131_RS20665 ENOG4108I69 Glycosyl transferases group 1 GR131_RS20670 ENOG4107SJB teichoic acid biosynthesis GR131_RS20675 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GR131_RS20690 ENOG4105II7 pyrroline-5-carboxylate reductase GR131_RS20695 ENOG4105TV9 FHA Domain-Containing protein GR131_RS20700 ENOG4108UGD Serine Threonine protein kinase GR131_RS20705 ENOG4108QVN serine threonine protein kinase GR131_RS20710 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GR131_RS20725 ENOG4105CAK Cell division ATP-binding protein ftsE GR131_RS20735 ENOG4105CN1 protease GR131_RS20740 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GR131_RS20755 ENOG4106NZI LysR family Transcriptional regulator GR131_RS20800 ENOG4105EEM helicase GR131_RS20810 ENOG4108426 dNA-binding protein GR131_RS20815 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GR131_RS20820 ENOG4108UJU UPF0301 protein GR131_RS20840 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GR131_RS20845 ENOG4105E2D ec 3.2.1.52 GR131_RS20860 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GR131_RS20885 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR131_RS20925 ENOG4105E2Y ABC, transporter GR131_RS20970 ENOG4105E90 ABC transporter GR131_RS20975 ENOG4108IJ8 ABC transporter GR131_RS20980 ENOG4105E90 ABC transporter GR131_RS20990 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GR131_RS21000 ENOG4105CQB FAD linked oxidase domain protein GR131_RS21005 ENOG4105KF0 sporulation and cell division protein, SsgA GR131_RS21025 ENOG4107G87 m6 family metalloprotease domain protein GR131_RS21035 ENOG4105BZU Histidine kinase GR131_RS21040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR131_RS21070 ENOG4108RWI nicotinamidase GR131_RS21080 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GR131_RS21095 ENOG4105C85 amino acid GR131_RS21115 ENOG4108RQ5 Beta-lactamase domain-containing protein GR131_RS21130 ENOG4105CI1 PTS System GR131_RS21135 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GR131_RS21145 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GR131_RS21155 ENOG4105CSH Transporter GR131_RS21170 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GR131_RS21180 ENOG4105BZ4 penicillin-binding protein GR131_RS21210 ENOG4106BRA Membrane GR131_RS21240 ENOG4107R4E Membrane GR131_RS21250 ENOG4105D9R oxidoreductase GR131_RS21275 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GR131_RS21305 ENOG4108M1A Chitin-binding protein GR131_RS21325 ENOG4105ECQ AraC Family Transcriptional Regulator GR131_RS21360 ENOG4105DV0 amidase (EC 3.5.1.4 GR131_RS21365 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GR131_RS21380 ENOG4105DEN Luciferase family GR131_RS21395 ENOG4105BZU Histidine kinase GR131_RS21450 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GR131_RS21500 ENOG4105CI3 gtp-binding protein typa GR131_RS21505 ENOG4105DEF Extracellular solute-binding protein, family 5 GR131_RS21510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS21515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS21525 ENOG4108JQ7 (ABC) transporter GR131_RS21535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS21540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS21545 ENOG4105C3U ABC transporter GR131_RS21550 ENOG4108JQ7 (ABC) transporter GR131_RS21575 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GR131_RS21600 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GR131_RS21605 ENOG4105C2J ABC transporter GR131_RS21610 ENOG4107R9N ABC transporter GR131_RS21615 ENOG4105CNN ABC, transporter GR131_RS21620 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS21625 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GR131_RS21630 ENOG41063JG Transcriptional regulator GR131_RS21635 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GR131_RS21640 ENOG4108Z4U Ferredoxin GR131_RS21665 ENOG4107R4C succinyl-diaminopimelate desuccinylase GR131_RS21670 ENOG4108URH decarboxylase GR131_RS21700 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GR131_RS21710 ENOG4105CGU Enoyl-CoA hydratase GR131_RS21725 ENOG4105DU6 RNA polymerase GR131_RS21735 ENOG4105C0H protease GR131_RS21740 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GR131_RS21780 ENOG4105D7N magnesium and cobalt transport protein CorA GR131_RS21790 ENOG4105DXB Major Facilitator superfamily GR131_RS21795 ENOG4105DB7 PHP domain protein GR131_RS21800 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GR131_RS21815 ENOG4105C1J atp-dependent rna helicase GR131_RS21910 ENOG4105C4R Atp-dependent dna helicase GR131_RS21915 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GR131_RS21940 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR131_RS22005 ENOG41063PX domain protein GR131_RS22015 ENOG4105DJZ UPF0182 protein GR131_RS22045 ENOG4107TK4 histidinol-phosphate phosphatase GR131_RS22055 ENOG4105KPY Small multidrug resistance protein GR131_RS22065 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GR131_RS22075 ENOG4108RAV Conserved protein GR131_RS22085 ENOG4105EMN RNA polymerase sigma factor GR131_RS22090 ENOG4105WMN AntiSigma factor GR131_RS22100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GR131_RS22110 ENOG41068W2 Cytochrome p-450 GR131_RS22115 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GR131_RS22120 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GR131_RS22130 ENOG4105D22 carbon starvation protein GR131_RS22135 ENOG4105FDP GntR family transcriptional regulator GR131_RS22155 ENOG4105D17 glycoside hydrolase, family 3 domain protein GR131_RS22160 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GR131_RS22175 ENOG4105CBD Diacylglycerol kinase GR131_RS22190 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GR131_RS22205 ENOG4105K6H D-cysteine desulfhydrase GR131_RS22220 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GR131_RS22225 ENOG41081JD Transcriptional regulator GR131_RS22230 ENOG4105ESN nucleotide-binding protein GR131_RS22275 ENOG4108VEQ Superoxide dismutase GR131_RS22290 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GR131_RS22295 ENOG4105CDA abc transporter atp-binding protein GR131_RS22310 ENOG4105C6K Malic enzyme GR131_RS22315 ENOG4105CB2 alcohol dehydrogenase GR131_RS22355 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GR131_RS22385 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GR131_RS22390 ENOG4105EB3 Histidine kinase GR131_RS22395 ENOG4108PYU two-component system response regulator GR131_RS22415 ENOG4105CJ1 ABC, transporter GR131_RS22440 ENOG4105C57 major facilitator superfamily GR131_RS22445 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GR131_RS22450 ENOG4108ZJ4 polysaccharide deacetylase GR131_RS22525 ENOG4107QHZ cell cycle protein GR131_RS22540 ENOG4105FDF Could be involved in DNA repair (By similarity) GR131_RS22545 ENOG4105E8V Alpha Beta Hydrolase Fold protein GR131_RS22555 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GR131_RS22560 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS22570 ENOG4105C26 Dehydrogenase GR131_RS22605 ENOG4105C75 arginyL-tRNA synthetase GR131_RS22610 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GR131_RS22615 ENOG4105D6E homoserine dehydrogenase GR131_RS22620 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GR131_RS22625 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GR131_RS22635 ENOG4108KGH TRANSCRIPTIONal GR131_RS22640 ENOG4105VFB Binds the 23S rRNA (By similarity) GR131_RS22645 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GR131_RS22650 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR131_RS22660 ENOG4107ZF2 Phosphatase GR131_RS22665 ENOG4105ESV Glycosyl transferase, family 4 GR131_RS22680 ENOG4105ZA1 atp synthase GR131_RS22685 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GR131_RS22690 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GR131_RS22695 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GR131_RS22700 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GR131_RS22705 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GR131_RS22710 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GR131_RS22730 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS22735 ENOG4105ENE Histidine kinase GR131_RS22740 ENOG4105IIP Membrane GR131_RS22750 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR131_RS22765 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GR131_RS22800 ENOG4105CJ1 ABC, transporter GR131_RS22820 ENOG4105CHU acetyl-coa acetyltransferase GR131_RS22845 ENOG41062D9 Histidine kinase GR131_RS22850 ENOG4105CHJ isochorismatase hydrolase GR131_RS22910 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GR131_RS22920 ENOG4105WX6 Membrane GR131_RS22970 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GR131_RS22975 ENOG4105C6K Malic enzyme GR131_RS22980 ENOG4105CTQ phosphohexokinase GR131_RS22985 ENOG4108MRH transcriptional regulatory protein GR131_RS22990 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GR131_RS22995 ENOG4107QJT sodium dicarboxylate symporter GR131_RS23010 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GR131_RS23015 ENOG4105DKW ABC transporter GR131_RS23030 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GR131_RS23035 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GR131_RS23040 ENOG4105CG3 alpha amylase, catalytic region GR131_RS23045 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GR131_RS23050 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GR131_RS23065 ENOG4105KVH Transcriptional regulator GR131_RS23075 ENOG4105BZ1 (ABC) transporter GR131_RS23080 ENOG4105BZ1 (ABC) transporter GR131_RS23105 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GR131_RS23155 ENOG4105ES4 Nitrilase GR131_RS23170 ENOG4105CSH Transporter GR131_RS23185 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GR131_RS23190 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GR131_RS23195 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GR131_RS23215 ENOG4105EJQ L-serine dehydratase GR131_RS23220 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GR131_RS23225 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GR131_RS23230 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GR131_RS23250 ENOG4105DEF Extracellular solute-binding protein, family 5 GR131_RS23255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS23260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS23265 ENOG4105C3U ABC transporter GR131_RS23270 ENOG4108JQ7 (ABC) transporter GR131_RS23275 ENOG4105EN6 Membrane GR131_RS23300 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GR131_RS23320 ENOG4105EMU Dehydrogenase GR131_RS23330 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GR131_RS23335 ENOG4105BZU Histidine kinase GR131_RS23340 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GR131_RS23345 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GR131_RS23355 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GR131_RS23360 ENOG4105EYF MMPL domain protein GR131_RS23375 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS23395 ENOG4105CPC Aldo Keto reductase GR131_RS23405 ENOG4105BZU Histidine kinase GR131_RS23415 ENOG4108ZP8 Acetolactate synthase small subunit GR131_RS23420 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GR131_RS23430 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR131_RS23450 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GR131_RS23460 ENOG4105C26 Dehydrogenase GR131_RS23485 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GR131_RS23490 ENOG4105CM2 brancheD-chain amino acid aminotransferase GR131_RS23500 ENOG4105CQM Urea amidohydrolase subunit alpha GR131_RS23505 ENOG4105DWY Agmatine deiminase GR131_RS23510 ENOG4105CSH Transporter GR131_RS23515 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GR131_RS23525 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein GR131_RS23545 ENOG4105PDP Short chain dehydrogenase GR131_RS23565 ENOG4107TXC Transcriptional regulator GR131_RS23610 ENOG4108YYC ycei family GR131_RS23620 ENOG4105D8K carboxyl transferase GR131_RS23640 ENOG4105GWZ Roadblock lc7 family protein GR131_RS23665 ENOG4105GWZ Roadblock lc7 family protein GR131_RS23680 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GR131_RS23685 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GR131_RS23730 ENOG41069M3 Transcriptional regulator GR131_RS23735 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GR131_RS23740 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GR131_RS23750 ENOG4105K70 DNA-binding protein GR131_RS23760 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) GR131_RS23770 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GR131_RS23775 ENOG4105CPF Cell wall formation (By similarity) GR131_RS23795 ENOG4105DWF phosphomethylpyrimidine kinase GR131_RS23800 ENOG4105VB9 50S ribosomal protein l28 GR131_RS23805 ENOG4105DP4 dak2 domain fusion protein ylov GR131_RS23815 ENOG4106H78 methyltransferase GR131_RS23820 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GR131_RS23835 ENOG41084BZ 50S ribosomal protein L32 GR131_RS23840 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GR131_RS23845 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GR131_RS23880 ENOG4105K4I Scp-like extracellular GR131_RS23885 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GR131_RS23895 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GR131_RS23930 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GR131_RS23940 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GR131_RS23955 ENOG4105K5M 30s ribosomal protein S16 GR131_RS23960 ENOG41082KU UPF0109 protein GR131_RS23965 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GR131_RS23970 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GR131_RS23975 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GR131_RS23980 ENOG4107QYR Signal peptidase i GR131_RS23985 ENOG4107QYR Signal peptidase i GR131_RS23990 ENOG4107QYR Signal peptidase i GR131_RS23995 ENOG4107QYR Signal peptidase i GR131_RS24000 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GR131_RS24010 ENOG41080R2 UPF0102 protein GR131_RS24015 ENOG4105C0P Mg chelatase subunit ChlI GR131_RS24025 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS24040 ENOG4105CE9 30S ribosomal protein S2 GR131_RS24045 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GR131_RS24050 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GR131_RS24055 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GR131_RS24060 ENOG4105KNE Phosphatidate cytidylyltransferase GR131_RS24065 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GR131_RS24075 ENOG4108I5D sulfate abc transporter GR131_RS24080 ENOG4108UCS ABC, transporter GR131_RS24100 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GR131_RS24105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GR131_RS24115 ENOG4105C26 Dehydrogenase GR131_RS24120 ENOG4105FQP Beta-lactamase GR131_RS24135 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GR131_RS24150 ENOG4105C26 Dehydrogenase GR131_RS24160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GR131_RS24165 ENOG4105F38 ABC transporter, permease GR131_RS24170 ENOG4105D38 putrescine abc transporter GR131_RS24175 ENOG4105CJP fad dependent oxidoreductase GR131_RS24205 ENOG4105G9B Transcriptional regulator GR131_RS24215 ENOG4105DKQ ROK family GR131_RS24220 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GR131_RS24225 ENOG4105DZP Membrane-associated zinc metalloprotease GR131_RS24230 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GR131_RS24245 ENOG4105DEF Extracellular solute-binding protein, family 5 GR131_RS24250 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS24255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS24260 ENOG4105C3U ABC transporter GR131_RS24275 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GR131_RS24295 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GR131_RS24310 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GR131_RS24320 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GR131_RS24325 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GR131_RS24340 ENOG4105DDN Pentapeptide repeat-containing protein GR131_RS24345 ENOG4108JQ7 (ABC) transporter GR131_RS24355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS24360 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS24365 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GR131_RS24380 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GR131_RS24385 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GR131_RS24390 ENOG4105C1V Peptidase, M16 GR131_RS24395 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GR131_RS24420 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GR131_RS24425 ENOG4105CN5 Metallo-Beta-Lactamase GR131_RS24460 ENOG4105BZU Histidine kinase GR131_RS24465 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GR131_RS24470 ENOG4107QZI cell division protein FtsK GR131_RS24480 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GR131_RS24490 ENOG4105CEV competence damage-inducible protein GR131_RS24495 ENOG4105WBV Transcriptional regulator GR131_RS24500 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GR131_RS24510 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GR131_RS24530 ENOG4105CIR epoxide hydrolase GR131_RS24535 ENOG4107QRT dEAD DEAH box helicase GR131_RS24540 ENOG41063TF transcriptional regulator (AraC GR131_RS24560 ENOG4105DSF transport protein GR131_RS24590 ENOG4105KC9 Modulates RecA activity (By similarity) GR131_RS24595 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GR131_RS24605 ENOG4107SCK Monooxygenase GR131_RS24610 ENOG4105DRP amino acid AbC transporter GR131_RS24615 ENOG4108Q1T ABC transporter GR131_RS24620 ENOG4107UBR Extracellular solute-binding protein family 3 GR131_RS24625 ENOG4105CDA abc transporter atp-binding protein GR131_RS24630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR131_RS24635 ENOG4105EB3 Histidine kinase GR131_RS24645 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GR131_RS24665 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GR131_RS24675 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GR131_RS24680 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GR131_RS24690 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GR131_RS24730 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GR131_RS24735 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GR131_RS24740 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GR131_RS24760 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GR131_RS24775 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GR131_RS24790 ENOG4105C9U ATP-dependent DNA helicase RecQ GR131_RS24810 ENOG4105DRR Transcriptional regulator, GntR family GR131_RS24815 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR131_RS24830 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GR131_RS24850 ENOG4107QN1 sodium solute GR131_RS24865 ENOG4105BZ7 extracellular solute-binding protein family 1 GR131_RS24875 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GR131_RS24880 ENOG4105CG3 alpha amylase, catalytic region GR131_RS24885 ENOG4107QRP cobalamin biosynthesis protein CobW GR131_RS24890 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GR131_RS24905 ENOG41061JJ Peptidase family M23 GR131_RS24910 ENOG4105DRR Transcriptional regulator, GntR family GR131_RS24915 ENOG410849S phosphocarrier protein (HPr) GR131_RS24965 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GR131_RS24975 ENOG4105F44 Two component transcriptional regulator, winged helix family GR131_RS24980 ENOG4106F60 Histidine kinase GR131_RS25005 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GR131_RS25025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GR131_RS25055 ENOG4107VEG TrkA-N domain protein GR131_RS25060 ENOG4105C0X amino acid GR131_RS25065 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GR131_RS25095 ENOG4106IBS oxygenase GR131_RS25105 ENOG4105WQT MbtH domain protein GR131_RS25115 ENOG41066YJ Beta-lactamase GR131_RS25125 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS25135 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR131_RS25145 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS25150 ENOG4105JNK Glycosyl transferase (Group 1 GR131_RS25170 ENOG4105CPQ Dehydrogenase GR131_RS25175 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GR131_RS25195 ENOG4108IV0 ABC, transporter GR131_RS25200 ENOG4105C0Z ABC transporter GR131_RS25210 ENOG4105C32 Amino acid ABC transporter (Permease) GR131_RS25215 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein GR131_RS25225 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GR131_RS25230 ENOG4105C2W permease GR131_RS25305 ENOG4105DHJ ABC, transporter GR131_RS25375 ENOG4105CV8 reductase GR131_RS25390 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GR131_RS25400 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GR131_RS25410 ENOG4105E2A Dehydrogenase GR131_RS25430 ENOG4105CHR reductase GR131_RS25445 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GR131_RS25465 ENOG4105CHR reductase GR131_RS25475 ENOG4107RB3 L-asparaginase GR131_RS25480 ENOG4105E2R ROK family GR131_RS25485 ENOG4105C2J ABC transporter GR131_RS25490 ENOG4105CNN ABC, transporter GR131_RS25495 ENOG4105CNN ABC, transporter GR131_RS25500 ENOG4105DFW ABC transporter GR131_RS25505 ENOG4107TTA Xylose isomerase domain protein TIM barrel GR131_RS25515 ENOG4106UW1 Major Facilitator superfamily GR131_RS25520 ENOG4108RFG Tetr family transcriptional regulator GR131_RS25525 ENOG4105C39 capsular polysaccharide phosphotransferase GR131_RS25550 ENOG4105EGE secreted protein GR131_RS25555 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR131_RS25575 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GR131_RS25595 ENOG4108ZHR arsR family transcriptional regulator GR131_RS25615 ENOG4105KA0 thioesterase Superfamily protein GR131_RS25625 ENOG4105DGI Alkaline phosphatase GR131_RS25645 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GR131_RS25660 ENOG4105DWV Homoserine O-trans-acetylase GR131_RS25685 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GR131_RS25695 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS25700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS25705 ENOG4108JQ6 ABC transporter GR131_RS25720 ENOG4105KVH Transcriptional regulator GR131_RS25730 ENOG4105DQ5 transport system permease protein GR131_RS25735 ENOG4105TVJ transport system, permease GR131_RS25740 ENOG4105E0A ABC, transporter GR131_RS25755 ENOG4105W0E 50S ribosomal protein L33 GR131_RS25765 ENOG4105BZ9 Cytochrome C oxidase, subunit I GR131_RS25805 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GR131_RS25815 ENOG4105DAA L-lactate GR131_RS25820 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GR131_RS25830 ENOG41080R8 Conserved Protein GR131_RS25845 ENOG4107QRI Phosphoketolase GR131_RS25885 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR131_RS25890 ENOG4107S1Q Phosphatase GR131_RS25905 ENOG4105CEU Arginine dihydrolase GR131_RS25910 ENOG4105DBV ornithine carbamoyltransferase GR131_RS25915 ENOG4105CUB amino acid GR131_RS25945 ENOG4106A3M Cytochrome p-450 GR131_RS25955 ENOG4105D65 subunit l GR131_RS25960 ENOG4105MKQ Monovalent cation H antiporter subunit C GR131_RS25965 ENOG4108JPZ Monovalent cation H antiporter subunit D GR131_RS25980 ENOG4105KJM monovalent cation h antiporter subunit g GR131_RS25985 ENOG4105CEU Arginine dihydrolase GR131_RS26005 ENOG4105S10 periplasmic binding protein GR131_RS26010 ENOG4105EHG Permease protein GR131_RS26015 ENOG4108W0P ABC transporter GR131_RS26035 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GR131_RS26060 ENOG4107QM5 aconitate hydratase GR131_RS26070 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GR131_RS26075 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GR131_RS26090 ENOG4105C2J ABC transporter GR131_RS26095 ENOG4107RNG ABC transporter GR131_RS26100 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GR131_RS26105 ENOG4105CUB amino acid GR131_RS26125 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR131_RS26130 ENOG4105CHU acetyl-coa acetyltransferase GR131_RS26150 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GR131_RS26155 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GR131_RS26165 ENOG4105C1Q protoporphyrinogen oxidase GR131_RS26170 ENOG4107JTW chlorite dismutase GR131_RS26180 ENOG4105E18 UPF0276 protein GR131_RS26190 ENOG4108ZJ4 polysaccharide deacetylase GR131_RS26200 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GR131_RS26215 ENOG4108KPJ rna polymerase sigma factor GR131_RS26220 ENOG4105CR4 methylisocitrate lyase GR131_RS26240 ENOG4105DFU Cell wall formation (By similarity) GR131_RS26245 ENOG4105E0X reductase GR131_RS26310 ENOG4108IRC dna polymerase iii GR131_RS26340 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GR131_RS26345 ENOG4108V06 Glutathione peroxidase GR131_RS26360 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GR131_RS26365 ENOG4105D7T ABC transporter GR131_RS26390 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) GR131_RS26395 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GR131_RS26405 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GR131_RS26415 ENOG4107RR1 TRANSCRIPTIONal GR131_RS26435 ENOG4105CSU acyl-Coa dehydrogenase GR131_RS26455 ENOG4107QK5 Homocysteine s-methyltransferase GR131_RS26480 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GR131_RS26490 ENOG4105E0A ABC, transporter GR131_RS26495 ENOG4105EHG Permease protein GR131_RS26515 ENOG4105CGD Nad-dependent epimerase dehydratase GR131_RS26520 ENOG4105CVP deoxyribo-dipyrimidine photolyase GR131_RS26525 ENOG4107TXC Transcriptional regulator GR131_RS26535 ENOG4105K6V RNA polymerase GR131_RS26575 ENOG4105M2Z protein tyrosine serine phosphatase GR131_RS26585 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GR131_RS26590 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GR131_RS26610 ENOG4105C7K acetolactate synthase GR131_RS26625 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GR131_RS26640 ENOG4105DRR Transcriptional regulator, GntR family GR131_RS26650 ENOG4105DTA methyltransferase GR131_RS26670 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GR131_RS26675 ENOG4105C7N Xanthine uracil vitamin C permease GR131_RS26730 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR131_RS26735 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS26745 ENOG41060W2 glyoxylate carboligase GR131_RS26750 ENOG4105CH6 catalase GR131_RS26755 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GR131_RS26760 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GR131_RS26780 ENOG4105VT2 5-hydroxyisourate hydrolase GR131_RS26790 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GR131_RS26840 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GR131_RS26845 ENOG4108HKT sucrose-6-phosphate hydrolase GR131_RS26850 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS26865 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS26870 ENOG4108HKT sucrose-6-phosphate hydrolase GR131_RS26875 ENOG4105BZ9 Cytochrome C oxidase, subunit I GR131_RS26880 ENOG4105GRZ Ycii-related protein GR131_RS26885 ENOG4105CHP RNA polymerase GR131_RS26890 ENOG41061JJ Peptidase family M23 GR131_RS26900 ENOG4107R9S Malate synthase GR131_RS26905 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GR131_RS26910 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GR131_RS26915 ENOG4105C7W Xanthine dehydrogenase GR131_RS26930 ENOG4107HP6 Transcriptional regulator GR131_RS26950 ENOG4105BZU Histidine kinase GR131_RS26955 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS26970 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GR131_RS26975 ENOG4105FDP GntR family transcriptional regulator GR131_RS26985 ENOG41062B0 ABC transporter, permease GR131_RS26990 ENOG4105C2J ABC transporter GR131_RS26995 ENOG4105DKQ ROK family GR131_RS27005 ENOG4105C0D helicase GR131_RS27095 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS27135 ENOG4105Q26 Siderophore-interacting protein GR131_RS27140 ENOG4105DQ5 transport system permease protein GR131_RS27145 ENOG4105TVJ transport system, permease GR131_RS27150 ENOG4105E0A ABC, transporter GR131_RS27160 ENOG4105BZ1 (ABC) transporter GR131_RS27165 ENOG41086IN PA14 GR131_RS27195 ENOG4105CSU acyl-Coa dehydrogenase GR131_RS27215 ENOG41088PD hydrolase GR131_RS27225 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GR131_RS27230 ENOG4105CI2 imidazolone-5-propionate hydrolase GR131_RS27260 ENOG4105CDA abc transporter atp-binding protein GR131_RS27265 ENOG4107UBR Extracellular solute-binding protein family 3 GR131_RS27270 ENOG4105EAD ABC transporter GR131_RS27275 ENOG4105DRP amino acid AbC transporter GR131_RS27295 ENOG4105E4C Lytic transglycosylase catalytic GR131_RS27330 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS27380 ENOG4105M4P Tetr family transcriptional regulator GR131_RS27395 ENOG4105DND Transcriptional regulator GR131_RS27425 ENOG410836F Transposase GR131_RS27435 ENOG4105E1F short-chain dehydrogenase reductase GR131_RS27480 ENOG4105BZU Histidine kinase GR131_RS27600 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GR131_RS27605 ENOG4105CSH Transporter GR131_RS27610 ENOG4105CMT Dihydroxyacetone kinase GR131_RS27615 ENOG4105CMT Dihydroxyacetone kinase GR131_RS27620 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GR131_RS27675 ENOG4105M4P Tetr family transcriptional regulator GR131_RS27680 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GR131_RS27710 ENOG4105FB9 CRISPR-associated protein GR131_RS27760 ENOG4105CDU Replicative dna helicase GR131_RS27850 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GR131_RS27910 ENOG4105ZXU NLP P60 protein GR131_RS27960 ENOG4105CPF Cell wall formation (By similarity) GR131_RS27980 ENOG4105GN4 DNA ligase GR131_RS28085 ENOG4108IAJ Nad-dependent epimerase dehydratase GR131_RS28105 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR131_RS28125 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GR131_RS28135 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GR131_RS28145 ENOG4105VF7 tolerance protein GR131_RS28175 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS28205 ENOG4105BZP glycoside hydrolase 15-related GR131_RS28255 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GR131_RS28280 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GR131_RS28300 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GR131_RS28305 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GR131_RS28310 ENOG4105ECY inositol monophosphatase GR131_RS28325 ENOG4108UVJ appr-1-p processing domain protein GR131_RS28340 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GR131_RS28365 ENOG4107T0D ABC, transporter GR131_RS28380 ENOG4105ECR NmrA family GR131_RS28385 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GR131_RS28400 ENOG4105C5H ABC transporter GR131_RS28405 ENOG4105BZW Glycerate kinase GR131_RS28415 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GR131_RS28420 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS28430 ENOG4105CI0 Citrate lyase GR131_RS28435 ENOG4105RFZ Methylmalonyl-coA mutase GR131_RS28440 ENOG4105EE1 crotonyl-CoA reductase GR131_RS28450 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR131_RS28455 ENOG4105E0A ABC, transporter GR131_RS28460 ENOG4105TVJ transport system, permease GR131_RS28465 ENOG4105DQ5 transport system permease protein GR131_RS28485 ENOG4106JDR secreted GR131_RS28510 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GR131_RS28520 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GR131_RS28540 ENOG4105D9U N-acetyltransferase GR131_RS28565 ENOG4105W1N transcriptional regulator GR131_RS28575 ENOG41061JJ Peptidase family M23 GR131_RS28580 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GR131_RS28595 ENOG4108Z0Z intracellular protease Pfpi family GR131_RS28655 ENOG4108IUE nitrate reductase beta subunit GR131_RS28685 ENOG410842T Pterin carbinolamine dehydratase GR131_RS28710 ENOG4107NQ8 LysR family Transcriptional regulator GR131_RS28715 ENOG4105DHU Bile acid GR131_RS28720 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GR131_RS28730 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR131_RS28735 ENOG4105DKQ ROK family GR131_RS28740 ENOG4105C2J ABC transporter GR131_RS28745 ENOG4105CNN ABC, transporter GR131_RS28750 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GR131_RS28820 ENOG4107U9T Pfam:Ribonuclease_BN GR131_RS28840 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS28845 ENOG4105C2J ABC transporter GR131_RS28850 ENOG4105CNN ABC, transporter GR131_RS28855 ENOG4108RVA ribokinase GR131_RS28860 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GR131_RS28875 ENOG4105D2S major facilitator superfamily GR131_RS28895 ENOG4105C26 Dehydrogenase GR131_RS28930 ENOG4105C7K acetolactate synthase GR131_RS28960 ENOG4108JJA ABC, transporter GR131_RS28980 ENOG4105XYF acetyltransferase GR131_RS29000 ENOG4108Z6Z Transcriptional regulator GR131_RS29035 ENOG4105E39 Enoyl-CoA hydratase GR131_RS29045 ENOG4105DQE DNA ligase GR131_RS29075 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS29085 ENOG4105JNK Glycosyl transferase (Group 1 GR131_RS29095 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR131_RS29105 ENOG4105C5H ABC transporter GR131_RS29110 ENOG4105KF0 sporulation and cell division protein, SsgA GR131_RS29115 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GR131_RS29125 ENOG4106ETB IIa component GR131_RS29155 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GR131_RS29160 ENOG4105EWC Purine nucleoside phosphorylase GR131_RS29165 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GR131_RS29175 ENOG4105CHU acetyl-coa acetyltransferase GR131_RS29180 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR131_RS29185 ENOG4108Z6Z Transcriptional regulator GR131_RS29190 ENOG4105C94 Transporter GR131_RS29215 ENOG4105DZC cytosine deaminase GR131_RS29220 ENOG4105CD3 dihydroorotase GR131_RS29225 ENOG4108WYP Transcriptional regulator GR131_RS29240 ENOG4105BZM domain protein GR131_RS29255 ENOG41060WC Enoyl-CoA hydratase GR131_RS29270 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GR131_RS29285 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GR131_RS29310 ENOG4105EY8 ABC transporter GR131_RS29315 ENOG4105FBD synthase GR131_RS29325 ENOG4107S11 squalene-associated FAD-dependent desaturase GR131_RS29335 ENOG4105EWU Squalene--hopene cyclase GR131_RS29370 ENOG41090WU lipolytic protein G-D-S-L family GR131_RS29465 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GR131_RS29470 ENOG4106FTQ Taurine ABC transporter, periplasmic GR131_RS29475 ENOG4108IY8 ABC, transporter GR131_RS29505 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GR131_RS29510 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GR131_RS29540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GR131_RS29555 ENOG4105CUC YeeE YedE family protein GR131_RS29560 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS29565 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR131_RS29580 ENOG4107RSM transcriptional regulator GR131_RS29585 ENOG4105CHU acetyl-coa acetyltransferase GR131_RS29590 ENOG4105CSH Transporter GR131_RS29665 ENOG4105EWK phytoene GR131_RS29670 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GR131_RS29675 ENOG4106A3M Cytochrome p-450 GR131_RS29685 ENOG4105CMG Carbohydrate kinase GR131_RS29710 ENOG4105C0D helicase GR131_RS29755 ENOG4105GWZ Roadblock lc7 family protein GR131_RS29770 ENOG4105C29 acyl-CoA thioesterase GR131_RS29785 ENOG4105BZ1 (ABC) transporter GR131_RS29790 ENOG4105BZ1 (ABC) transporter GR131_RS29810 ENOG4105BZ1 (ABC) transporter GR131_RS29820 ENOG4105H3G oxidoreductase GR131_RS29825 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GR131_RS29835 ENOG4105E2Y ABC, transporter GR131_RS29840 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GR131_RS29845 ENOG4107ZED Uncharacterised protein family UPF0047 GR131_RS29850 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS29860 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GR131_RS29870 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GR131_RS29880 ENOG4105YA8 Transcriptional regulator GR131_RS29885 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR131_RS29890 ENOG4105EJ2 Transcriptional regulator GR131_RS29895 ENOG4105C26 Dehydrogenase GR131_RS29905 ENOG4108IPT Naphthoate synthase GR131_RS29925 ENOG4105CR4 methylisocitrate lyase GR131_RS29940 ENOG4107R9S Malate synthase GR131_RS29965 ENOG4107QNK )-transporter GR131_RS29970 ENOG41075H3 AraC family transcriptional regulator GR131_RS29975 ENOG4105E0A ABC, transporter GR131_RS29985 ENOG4105S6R Iron-hydroxamate transporter permease subunit GR131_RS30000 ENOG4107VXZ Hydrolase GR131_RS30025 ENOG4105DND Transcriptional regulator GR131_RS30030 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GR131_RS30045 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GR131_RS30050 ENOG4105CVM Molybdenum cofactor synthesis domain protein GR131_RS30065 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GR131_RS30070 ENOG4105CVK Glutamate decarboxylase GR131_RS30075 ENOG4105VN1 Heat shock protein GR131_RS30090 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GR131_RS30105 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GR131_RS30120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GR131_RS30125 ENOG4105YVS arsR family transcriptional regulator GR131_RS30130 ENOG4105C2W permease GR131_RS30160 ENOG410841Q phosphoesterase PA-phosphatase related protein GR131_RS30195 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GR131_RS30210 ENOG4105C5W Aldolase GR131_RS30235 ENOG4105C10 Electron transfer flavoprotein GR131_RS30245 ENOG41060NJ transcriptional regulator GR131_RS30265 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GR131_RS30275 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS30290 ENOG4106UW1 Major Facilitator superfamily GR131_RS30300 ENOG4105DKQ ROK family GR131_RS30320 ENOG4105MVE transcriptional regulator GR131_RS30340 ENOG4105QVC MOSC domain-containing protein GR131_RS30355 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GR131_RS30365 ENOG4105C1J atp-dependent rna helicase GR131_RS30375 ENOG4108JW7 Maf-like protein GR131_RS30405 ENOG4105NTW Transcriptional regulator GR131_RS30420 ENOG41068HZ 50S ribosomal protein L32 GR131_RS30460 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GR131_RS30465 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GR131_RS30470 ENOG4105DM4 PTS System GR131_RS30475 ENOG4105DE4 1-phosphofructokinase GR131_RS30480 ENOG410804X Transcriptional regulator GR131_RS30505 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR131_RS30515 ENOG4105C1G acyl-Coa dehydrogenase GR131_RS30525 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR131_RS30545 ENOG4105E0A ABC, transporter GR131_RS30550 ENOG4105J76 Periplasmic binding protein GR131_RS30555 ENOG4105S6R Iron-hydroxamate transporter permease subunit GR131_RS30560 ENOG4105NPE arsR family transcriptional regulator GR131_RS30565 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GR131_RS30575 ENOG4107S9F NmrA family GR131_RS30595 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GR131_RS30615 ENOG4105CJ1 ABC, transporter GR131_RS30620 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GR131_RS30625 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GR131_RS30655 ENOG4105CPC Aldo Keto reductase GR131_RS30680 ENOG4105CP7 Triose-phosphate isomerase GR131_RS30700 ENOG4105NAF rna polymerase sigma factor GR131_RS30735 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GR131_RS30740 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GR131_RS30755 ENOG4105CSH Transporter GR131_RS30780 ENOG4105EG6 Saccharopine dehydrogenase GR131_RS30800 ENOG4105EUB pirin domain protein GR131_RS30805 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GR131_RS30820 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS30840 ENOG4107S91 Sodium hydrogen exchanger GR131_RS30885 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GR131_RS30905 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GR131_RS30915 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GR131_RS30930 ENOG4105D65 subunit l GR131_RS30935 ENOG4105C8S subunit m GR131_RS30940 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR131_RS30975 ENOG4106KE4 Dehydrogenase GR131_RS31005 ENOG4108K8S endonuclease I GR131_RS31015 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) GR131_RS31025 ENOG4108YV4 Universal stress protein GR131_RS31030 ENOG4105CEY Amp-dependent synthetase and ligase GR131_RS31085 ENOG4105CQB FAD linked oxidase domain protein GR131_RS31105 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS31110 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GR131_RS31120 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GR131_RS31145 ENOG4107S1E Beta-lactamase GR131_RS31160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR131_RS31165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR131_RS31175 ENOG4108JQ7 (ABC) transporter GR131_RS31190 ENOG4105DTQ mandelate racemase muconate lactonizing GR131_RS31225 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GR131_RS31280 ENOG4105CSH Transporter GR131_RS31305 ENOG4105BZU Histidine kinase GR131_RS31310 ENOG4105WH1 Two component transcriptional regulator luxr family GR131_RS31320 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GR131_RS31325 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GR131_RS31330 ENOG4105C7W Xanthine dehydrogenase GR131_RS31355 ENOG4105CSH Transporter GR131_RS31360 ENOG4108KEZ Dehydrogenase GR131_RS31380 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GR131_RS31385 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GR131_RS31390 ENOG4105ETE Transcriptional regulator (LacI family GR131_RS31395 ENOG4105C4C beta-galactosidase GR131_RS31400 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GR131_RS31440 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)