locus-tag	class	description
GR131_RS00200	COG1396	sequence-specific DNA binding
GR131_RS00255	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS00260	COG3246	L-lysine catabolic process to acetate
GR131_RS00290	COG0477	Major facilitator Superfamily
GR131_RS00310	COG0156	8-amino-7-oxononanoate synthase activity
GR131_RS00315	COG4335	DNA alkylation repair
GR131_RS00325	COG4221	oxidoreductase activity
GR131_RS00325	COG3321	synthase
GR131_RS00325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR131_RS00325	COG0300	oxidoreductase activity
GR131_RS00345	COG0583	DNA-binding transcription factor activity
GR131_RS00370	COG1404	Belongs to the peptidase S8 family
GR131_RS00400	COG0515	serine threonine protein kinase
GR131_RS00450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR131_RS00475	COG3396	Phenylacetate-CoA oxygenase
GR131_RS00485	COG3396	Phenylacetate-CoA oxygenase
GR131_RS00490	COG2151	metal-sulfur cluster biosynthetic enzyme
GR131_RS00495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GR131_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS00505	COG3483	tryptophan 2,3-dioxygenase activity
GR131_RS00535	COG1129	ABC transporter
GR131_RS00545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR131_RS00580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GR131_RS00585	COG2124	cytochrome p450
GR131_RS00605	COG3321	synthase
GR131_RS00605	COG0604	alcohol dehydrogenase
GR131_RS00605	COG3321	synthase
GR131_RS00605	COG0604	alcohol dehydrogenase
GR131_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS00735	COG2814	Major facilitator Superfamily
GR131_RS00745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GR131_RS00750	COG0277	FAD linked oxidase domain protein
GR131_RS00775	COG2318	DinB family
GR131_RS00780	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GR131_RS00790	COG1124	(ABC) transporter
GR131_RS00795	COG0444	Belongs to the ABC transporter superfamily
GR131_RS00800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR131_RS00805	COG0601	transmembrane transport
GR131_RS00815	COG1960	acyl-CoA dehydrogenase activity
GR131_RS00820	COG1960	acyl-CoA dehydrogenase activity
GR131_RS00845	COG0517	IMP dehydrogenase activity
GR131_RS00845	COG1125	glycine betaine transport
GR131_RS00855	COG1174	glycine betaine transport
GR131_RS00860	COG1174	glycine betaine transport
GR131_RS00865	COG2124	cytochrome p450
GR131_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS00900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS00905	COG4608	Belongs to the ABC transporter superfamily
GR131_RS00945	COG0235	Class ii aldolase
GR131_RS00950	COG3395	kinase activity
GR131_RS00965	COG1349	DNA-binding transcription factor activity
GR131_RS00985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GR131_RS00995	COG3971	2-oxopent-4-enoate hydratase activity
GR131_RS01000	COG1414	Transcriptional regulator
GR131_RS01025	COG0242	peptide deformylase activity
GR131_RS01040	COG0110	maltose O-acetyltransferase activity
GR131_RS01050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GR131_RS01055	COG1132	(ABC) transporter
GR131_RS01060	COG1132	(ABC) transporter
GR131_RS01085	COG1120	ATPase activity
GR131_RS01095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS01125	COG1984	allophanate hydrolase subunit 2
GR131_RS01130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GR131_RS01135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GR131_RS01170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GR131_RS01180	COG0300	oxidoreductase activity
GR131_RS01185	COG2201	protein-glutamate methylesterase activity
GR131_RS01215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR131_RS01220	COG0590	tRNA wobble adenosine to inosine editing
GR131_RS01225	COG0363	glucosamine-6-phosphate deaminase activity
GR131_RS01230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GR131_RS01240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GR131_RS01250	COG3458	cephalosporin-C deacetylase activity
GR131_RS01260	COG0747	negative chemotaxis
GR131_RS01265	COG0601	transmembrane transport
GR131_RS01270	COG0444	Belongs to the ABC transporter superfamily
GR131_RS01275	COG4608	Belongs to the ABC transporter superfamily
GR131_RS01280	COG1121	(ABC) transporter
GR131_RS01285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GR131_RS01295	COG0803	Belongs to the bacterial solute-binding protein 9 family
GR131_RS01305	COG4257	antibiotic catabolic process
GR131_RS01315	COG3655	Transcriptional regulator
GR131_RS01335	COG0464	growth
GR131_RS01405	COG4948	Mandelate Racemase Muconate Lactonizing
GR131_RS01425	COG3119	arylsulfatase activity
GR131_RS01455	COG0477	Major facilitator Superfamily
GR131_RS01485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GR131_RS01490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GR131_RS01495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GR131_RS01500	COG0254	rRNA binding
GR131_RS01510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GR131_RS01535	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GR131_RS01545	COG3293	Transposase
GR131_RS01575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GR131_RS01575	COG1796	DNA polymerase
GR131_RS01585	COG2837	iron assimilation
GR131_RS01610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GR131_RS01615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GR131_RS01635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GR131_RS01640	COG0121	glutamine amidotransferase
GR131_RS01645	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GR131_RS01655	COG3360	Dodecin
GR131_RS01665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS01670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GR131_RS01675	COG1053	succinate dehydrogenase
GR131_RS01685	COG0583	DNA-binding transcription factor activity
GR131_RS01720	COG0726	polysaccharide deacetylase
GR131_RS01745	COG1733	regulation of RNA biosynthetic process
GR131_RS01750	COG3275	phosphorelay sensor kinase activity
GR131_RS01755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR131_RS01765	COG3279	Response regulator of the LytR AlgR family
GR131_RS01770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GR131_RS01805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GR131_RS01810	COG2313	pseudouridylate synthase activity
GR131_RS01820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR131_RS01825	COG0546	phosphoglycolate phosphatase activity
GR131_RS01830	COG0697	spore germination
GR131_RS01835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GR131_RS01855	COG1132	(ABC) transporter
GR131_RS01865	COG1595	DNA-templated transcription, initiation
GR131_RS01875	COG0656	L-ascorbic acid biosynthetic process
GR131_RS01895	COG0784	Response regulator, receiver
GR131_RS01900	COG4251	negative regulation of phosphorylation
GR131_RS01945	COG0501	Belongs to the peptidase M48B family
GR131_RS01950	COG2723	6-phospho-beta-galactosidase activity
GR131_RS01955	COG0395	ABC-type sugar transport system, permease component
GR131_RS01985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GR131_RS02005	COG1960	acyl-CoA dehydrogenase activity
GR131_RS02015	COG0242	peptide deformylase activity
GR131_RS02025	COG3442	glutamine amidotransferase
GR131_RS02030	COG0205	6-phosphofructokinase activity
GR131_RS02040	COG2208	phosphoserine phosphatase activity
GR131_RS02040	COG2770	Histidine kinase
GR131_RS02055	COG0435	Glutathione S-transferase
GR131_RS02065	COG2175	clavaminate synthase activity
GR131_RS02110	COG0204	Acyl-transferase
GR131_RS02115	COG4552	Acetyltransferase involved in intracellular survival and related
GR131_RS02120	COG0829	nickel cation binding
GR131_RS02125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GR131_RS02135	COG0804	urea catabolic process
GR131_RS02140	COG0832	Belongs to the urease beta subunit family
GR131_RS02145	COG0831	urea catabolic process
GR131_RS02155	COG0740	serine-type endopeptidase activity
GR131_RS02160	COG0791	NLP P60 protein
GR131_RS02185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GR131_RS02190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GR131_RS02195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GR131_RS02205	COG0488	(ABC) transporter
GR131_RS02210	COG0488	(ABC) transporter
GR131_RS02245	COG2197	response regulator
GR131_RS02260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS02265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS02365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GR131_RS02370	COG3663	DNA glycosylase
GR131_RS02385	COG1940	carbohydrate kinase activity
GR131_RS02390	COG2188	Transcriptional regulator
GR131_RS02415	COG0626	cystathionine gamma-synthase activity
GR131_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS02440	COG1522	sequence-specific DNA binding
GR131_RS02445	COG0419	ATPase involved in DNA repair
GR131_RS02450	COG0420	3'-5' exonuclease activity
GR131_RS02465	COG1595	DNA-templated transcription, initiation
GR131_RS02485	COG1739	Uncharacterized protein family UPF0029
GR131_RS02490	COG1832	CoA-binding protein
GR131_RS02500	COG0110	maltose O-acetyltransferase activity
GR131_RS02560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GR131_RS02580	COG1968	undecaprenyl-diphosphatase activity
GR131_RS02590	COG1982	Orn Lys Arg decarboxylase major
GR131_RS02610	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GR131_RS02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GR131_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS02680	COG0154	amidase activity
GR131_RS02690	COG4251	negative regulation of phosphorylation
GR131_RS02710	COG0697	spore germination
GR131_RS02725	COG0697	spore germination
GR131_RS02745	COG0539	negative regulation of cytoplasmic translation
GR131_RS02785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GR131_RS02785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GR131_RS02795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GR131_RS02815	COG1716	ATPase activity
GR131_RS02835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GR131_RS02865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GR131_RS02875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GR131_RS02895	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GR131_RS02985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR131_RS02990	COG2364	Membrane
GR131_RS03000	COG2270	Major facilitator Superfamily
GR131_RS03010	COG3030	protein affecting phage T7 exclusion by the F plasmid
GR131_RS03015	COG0463	Glycosyl transferase, family 2
GR131_RS03035	COG1960	acyl-CoA dehydrogenase activity
GR131_RS03065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GR131_RS03070	COG0140	phosphoribosyl-ATP diphosphatase activity
GR131_RS03075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GR131_RS03080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GR131_RS03080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GR131_RS03085	COG3201	nicotinamide mononucleotide transporter
GR131_RS03100	COG1090	epimerase
GR131_RS03105	COG1940	carbohydrate kinase activity
GR131_RS03105	COG1846	Transcriptional regulator
GR131_RS03110	COG0738	Major facilitator superfamily
GR131_RS03120	COG2233	PERMEase
GR131_RS03125	COG0697	spore germination
GR131_RS03145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR131_RS03185	COG2390	Transcriptional regulator
GR131_RS03190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GR131_RS03195	COG2318	DinB family
GR131_RS03210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GR131_RS03225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GR131_RS03235	COG1758	RNA polymerase activity
GR131_RS03250	COG0284	orotidine-5'-phosphate decarboxylase activity
GR131_RS03255	COG0167	dihydroorotate dehydrogenase activity
GR131_RS03260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GR131_RS03265	COG0505	Belongs to the CarA family
GR131_RS03275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR131_RS03280	COG0540	Belongs to the ATCase OTCase family
GR131_RS03285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GR131_RS03295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GR131_RS03300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GR131_RS03305	COG0006	proline dipeptidase activity
GR131_RS03315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GR131_RS03320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GR131_RS03325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GR131_RS03330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GR131_RS03335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GR131_RS03340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GR131_RS03345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GR131_RS03360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GR131_RS03375	COG0124	histidyl-tRNA synthetase
GR131_RS03385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GR131_RS03390	COG1196	nuclear chromosome segregation
GR131_RS03400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GR131_RS03405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GR131_RS03410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GR131_RS03415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GR131_RS03425	COG2255	four-way junction helicase activity
GR131_RS03430	COG0632	four-way junction helicase activity
GR131_RS03435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GR131_RS03440	COG0217	transcriptional regulatory protein
GR131_RS03445	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GR131_RS03450	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GR131_RS03460	COG0438	transferase activity, transferring glycosyl groups
GR131_RS03465	COG1560	Kdo2-lipid A biosynthetic process
GR131_RS03485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR131_RS03490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GR131_RS03545	COG0456	acetyltransferase
GR131_RS03620	COG1648	precorrin-2 dehydrogenase activity
GR131_RS03620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GR131_RS03625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GR131_RS03640	COG1464	Belongs to the NlpA lipoprotein family
GR131_RS03645	COG1464	Belongs to the NlpA lipoprotein family
GR131_RS03650	COG2011	ABC-type metal ion transport system permease component
GR131_RS03655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GR131_RS03660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GR131_RS03685	COG0584	glycerophosphoryl diester phosphodiesterase
GR131_RS03690	COG0204	Acyl-transferase
GR131_RS03690	COG0318	PFAM AMP-dependent synthetase and ligase
GR131_RS03695	COG0477	Major facilitator Superfamily
GR131_RS03715	COG0165	Argininosuccinate lyase
GR131_RS03725	COG0385	Bile acid
GR131_RS03730	COG2409	Drug exporters of the RND superfamily
GR131_RS03740	COG2197	response regulator
GR131_RS03745	COG4585	Histidine kinase
GR131_RS03750	COG1438	arginine binding
GR131_RS03755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GR131_RS03760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GR131_RS03765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GR131_RS03770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GR131_RS03800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GR131_RS03815	COG1309	transcriptional regulator
GR131_RS03830	COG2838	Isocitrate dehydrogenase
GR131_RS03850	COG0477	Major facilitator Superfamily
GR131_RS03870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR131_RS03875	COG0697	spore germination
GR131_RS03905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR131_RS03905	COG0072	phenylalanine-tRNA ligase activity
GR131_RS03910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GR131_RS03915	COG5002	protein histidine kinase activity
GR131_RS03925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GR131_RS03930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GR131_RS03935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GR131_RS03940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GR131_RS03950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GR131_RS03985	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS03990	COG0174	glutamine synthetase
GR131_RS03995	COG2186	Transcriptional regulator
GR131_RS04000	COG0531	amino acid
GR131_RS04005	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GR131_RS04030	COG0517	IMP dehydrogenase activity
GR131_RS04030	COG4175	Glycine betaine
GR131_RS04035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GR131_RS04045	COG1595	DNA-templated transcription, initiation
GR131_RS04055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GR131_RS04065	COG0564	pseudouridine synthase activity
GR131_RS04095	COG2124	cytochrome p450
GR131_RS04110	COG0805	protein transport
GR131_RS04115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GR131_RS04150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GR131_RS04165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GR131_RS04170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GR131_RS04180	COG4122	O-methyltransferase activity
GR131_RS04185	COG1222	aaa ATPase
GR131_RS04205	COG0517	IMP dehydrogenase activity
GR131_RS04205	COG1994	Peptidase M50
GR131_RS04215	COG2197	response regulator
GR131_RS04220	COG0747	negative chemotaxis
GR131_RS04230	COG1410	methionine synthase
GR131_RS04230	COG0646	methionine synthase
GR131_RS04240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GR131_RS04245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GR131_RS04250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GR131_RS04265	COG0215	cysteine-tRNA ligase activity
GR131_RS04285	COG0598	Magnesium transport protein CorA
GR131_RS04295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS04300	COG0667	Aldo Keto reductase
GR131_RS04330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR131_RS04340	COG3189	MarR family transcriptional regulator
GR131_RS04345	COG3012	SEC-C Motif Domain Protein
GR131_RS04355	COG3265	gluconokinase activity
GR131_RS04395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GR131_RS04400	COG2149	membrane
GR131_RS04420	COG1960	acyl-CoA dehydrogenase activity
GR131_RS04430	COG0318	PFAM AMP-dependent synthetase and ligase
GR131_RS04445	COG0488	(ABC) transporter
GR131_RS04455	COG3876	Protein conserved in bacteria
GR131_RS04500	COG1309	transcriptional regulator
GR131_RS04520	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GR131_RS04530	COG3973	AAA domain
GR131_RS04550	COG2755	lipolytic protein G-D-S-L family
GR131_RS04575	COG1216	Glycosyl transferase, family 2
GR131_RS04640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GR131_RS04645	COG0587	DNA-directed DNA polymerase activity
GR131_RS04660	COG0330	HflC and HflK could
GR131_RS04720	COG1799	cell septum assembly
GR131_RS04725	COG0477	Major facilitator Superfamily
GR131_RS04735	COG0671	phosphoesterase, PA-phosphatase related
GR131_RS04755	COG0438	transferase activity, transferring glycosyl groups
GR131_RS04775	COG1160	GTP binding
GR131_RS04785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GR131_RS04800	COG3541	Predicted nucleotidyltransferase
GR131_RS04805	COG1397	ADP-ribosylglycohydrolase
GR131_RS04815	COG1187	pseudouridine synthase activity
GR131_RS04820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GR131_RS04825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GR131_RS04840	COG0686	Belongs to the AlaDH PNT family
GR131_RS04850	COG0494	nUDIX hydrolase
GR131_RS04855	COG0504	CTP synthase activity
GR131_RS04860	COG3387	PFAM Glycoside hydrolase 15-related
GR131_RS04875	COG3896	Chloramphenicol phosphotransferase-like protein
GR131_RS04895	COG0497	DNA recombination
GR131_RS04900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GR131_RS04920	COG0647	UMP catabolic process
GR131_RS04955	COG2094	Belongs to the DNA glycosylase MPG family
GR131_RS04965	COG1881	PFAM PEBP family protein
GR131_RS04985	COG1119	ATPase activity
GR131_RS05000	COG2197	response regulator
GR131_RS05015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GR131_RS05025	COG1716	ATPase activity
GR131_RS05025	COG0842	Transport permease protein
GR131_RS05025	COG1131	(ABC) transporter
GR131_RS05030	COG3830	Belongs to the UPF0237 family
GR131_RS05030	COG0560	Phosphoserine phosphatase
GR131_RS05045	COG2807	transmembrane transport
GR131_RS05050	COG2186	Transcriptional regulator
GR131_RS05060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GR131_RS05070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GR131_RS05075	COG2261	transglycosylase associated protein
GR131_RS05095	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GR131_RS05105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GR131_RS05110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR131_RS05125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR131_RS05145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GR131_RS05200	COG0488	(ABC) transporter
GR131_RS05220	COG0235	Class ii aldolase
GR131_RS05235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GR131_RS05240	COG1492	cobalamin metabolic process
GR131_RS05255	COG1797	cobyrinic acid a,c-diamide synthase activity
GR131_RS05285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GR131_RS05290	COG0456	acetyltransferase
GR131_RS05300	COG1917	Cupin 2, conserved barrel domain protein
GR131_RS05305	COG5285	phytanoyl-CoA dioxygenase
GR131_RS05310	COG1902	pentaerythritol trinitrate reductase activity
GR131_RS05340	COG4585	Histidine kinase
GR131_RS05345	COG2197	response regulator
GR131_RS05380	COG2171	N-acyltransferase activity
GR131_RS05390	COG0822	iron-sulfur transferase activity
GR131_RS05395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GR131_RS05400	COG0396	ATPase activity
GR131_RS05410	COG0719	Fe-S assembly protein
GR131_RS05425	COG1131	(ABC) transporter
GR131_RS05450	COG0109	protoheme IX farnesyltransferase activity
GR131_RS05455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GR131_RS05460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GR131_RS05475	COG0363	glucosamine-6-phosphate deaminase activity
GR131_RS05480	COG0166	Belongs to the GPI family
GR131_RS05490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GR131_RS05495	COG0149	triose-phosphate isomerase activity
GR131_RS05500	COG0126	phosphoglycerate kinase activity
GR131_RS05505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GR131_RS05510	COG1481	regulation of sporulation
GR131_RS05520	COG1660	Displays ATPase and GTPase activities
GR131_RS05525	COG0322	excinuclease ABC activity
GR131_RS05540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GR131_RS05550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GR131_RS05555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GR131_RS05560	COG0861	Integral membrane protein TerC family
GR131_RS05575	COG0556	nucleotide-excision repair
GR131_RS05585	COG0584	glycerophosphoryl diester phosphodiesterase
GR131_RS05590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GR131_RS05595	COG0477	Major facilitator Superfamily
GR131_RS05645	COG1288	antiporter activity
GR131_RS05675	COG0237	dephospho-CoA kinase activity
GR131_RS05695	COG2226	methyltransferase
GR131_RS05700	COG1643	Atp-dependent helicase
GR131_RS05720	COG2050	protein possibly involved in aromatic compounds catabolism
GR131_RS05725	COG2746	aminoglycoside 3-N-acetyltransferase activity
GR131_RS05735	COG0559	Belongs to the binding-protein-dependent transport system permease family
GR131_RS05745	COG0411	ABC transporter
GR131_RS05750	COG0410	ABC transporter
GR131_RS05775	COG0737	Belongs to the 5'-nucleotidase family
GR131_RS05780	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GR131_RS05810	COG1605	Chorismate mutase
GR131_RS05810	COG0287	Prephenate dehydrogenase
GR131_RS05820	COG0513	Belongs to the DEAD box helicase family
GR131_RS05825	COG1278	Cold shock
GR131_RS05840	COG0070	glutamate synthase
GR131_RS05840	COG0069	glutamate synthase activity
GR131_RS05840	COG0067	glutamate synthase
GR131_RS05870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GR131_RS05875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR131_RS05885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GR131_RS05895	COG0159	tryptophan synthase activity
GR131_RS05900	COG0133	tryptophan synthase activity
GR131_RS05905	COG0134	indole-3-glycerol-phosphate synthase activity
GR131_RS05935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GR131_RS05945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GR131_RS05950	COG0107	imidazoleglycerol-phosphate synthase activity
GR131_RS05955	COG0251	oxidation-reduction process
GR131_RS05960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GR131_RS05965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GR131_RS05970	COG0131	Imidazoleglycerol-phosphate dehydratase
GR131_RS05975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GR131_RS05980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GR131_RS06000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GR131_RS06020	COG1432	Conserved Protein
GR131_RS06025	COG0587	DNA-directed DNA polymerase activity
GR131_RS06045	COG0515	serine threonine protein kinase
GR131_RS06060	COG2153	protein acetylation
GR131_RS06070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GR131_RS06075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GR131_RS06080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GR131_RS06090	COG3599	regulation of cell shape
GR131_RS06100	COG1799	cell septum assembly
GR131_RS06115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GR131_RS06120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GR131_RS06125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GR131_RS06135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GR131_RS06140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GR131_RS06150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GR131_RS06165	COG0275	rRNA processing
GR131_RS06175	COG0714	Associated with various cellular activities
GR131_RS06195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GR131_RS06200	COG1121	(ABC) transporter
GR131_RS06210	COG1309	transcriptional regulator
GR131_RS06230	COG0352	thiamine-phosphate diphosphorylase activity
GR131_RS06240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR131_RS06255	COG2022	thiamine diphosphate biosynthetic process
GR131_RS06260	COG2815	serine threonine protein kinase
GR131_RS06260	COG0515	serine threonine protein kinase
GR131_RS06265	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GR131_RS06270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GR131_RS06275	COG2193	ferroxidase activity
GR131_RS06280	COG0243	molybdopterin cofactor binding
GR131_RS06285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GR131_RS06300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GR131_RS06305	COG2197	response regulator
GR131_RS06310	COG4585	Histidine kinase
GR131_RS06335	COG1940	carbohydrate kinase activity
GR131_RS06345	COG0003	Pfam Anion-transporting ATPase
GR131_RS06365	COG0438	transferase activity, transferring glycosyl groups
GR131_RS06400	COG0705	Rhomboid family
GR131_RS06415	COG5002	protein histidine kinase activity
GR131_RS06420	COG0745	RESPONSE REGULATOR receiver
GR131_RS06430	COG1929	Belongs to the glycerate kinase type-1 family
GR131_RS06435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GR131_RS06440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GR131_RS06445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GR131_RS06450	COG0723	plastoquinol--plastocyanin reductase activity
GR131_RS06455	COG2010	Cytochrome c
GR131_RS06460	COG1845	cytochrome c oxidase, subunit III
GR131_RS06470	COG1376	ErfK ybiS ycfS ynhG family protein
GR131_RS06480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GR131_RS06485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GR131_RS06490	COG1104	cysteine desulfurase activity
GR131_RS06520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GR131_RS06525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GR131_RS06530	COG2197	response regulator
GR131_RS06575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GR131_RS06585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GR131_RS06590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GR131_RS06595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GR131_RS06600	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR131_RS06610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GR131_RS06625	COG4221	oxidoreductase activity
GR131_RS06660	COG0321	lipoyl(octanoyl) transferase activity
GR131_RS06665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GR131_RS06700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GR131_RS06710	COG2376	Dihydroxyacetone kinase
GR131_RS06720	COG2326	polyphosphate kinase activity
GR131_RS06785	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS06815	COG0745	RESPONSE REGULATOR receiver
GR131_RS06840	COG1309	transcriptional regulator
GR131_RS06845	COG0454	-acetyltransferase
GR131_RS06845	COG0456	acetyltransferase
GR131_RS06870	COG0395	ABC-type sugar transport system, permease component
GR131_RS06875	COG1175	transmembrane transport
GR131_RS06880	COG2182	Extracellular solute-binding protein
GR131_RS06885	COG1609	Transcriptional regulator
GR131_RS06900	COG1228	amidohydrolase
GR131_RS06905	COG0531	amino acid
GR131_RS06920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GR131_RS06965	COG2186	Transcriptional regulator
GR131_RS07035	COG0174	glutamine synthetase
GR131_RS07055	COG2132	Multicopper oxidase
GR131_RS07060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR131_RS07060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GR131_RS07075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GR131_RS07080	COG1994	Peptidase M50
GR131_RS07125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GR131_RS07130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS07135	COG1120	ATPase activity
GR131_RS07155	COG1834	amidinotransferase
GR131_RS07165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GR131_RS07170	COG2814	Major facilitator Superfamily
GR131_RS07180	COG0076	glutamate decarboxylase activity
GR131_RS07200	COG0384	phenazine biosynthesis protein PhzF
GR131_RS07205	COG2226	methyltransferase
GR131_RS07225	COG1733	regulation of RNA biosynthetic process
GR131_RS07265	COG3022	response to hydroperoxide
GR131_RS07270	COG0800	Aldolase
GR131_RS07275	COG0406	alpha-ribazole phosphatase activity
GR131_RS07275	COG0328	RNA-DNA hybrid ribonuclease activity
GR131_RS07285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GR131_RS07295	COG1131	(ABC) transporter
GR131_RS07305	COG4585	Histidine kinase
GR131_RS07310	COG0346	lactoylglutathione lyase activity
GR131_RS07315	COG2197	response regulator
GR131_RS07330	COG1960	acyl-CoA dehydrogenase activity
GR131_RS07335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR131_RS07340	COG0477	Major facilitator Superfamily
GR131_RS07370	COG0438	transferase activity, transferring glycosyl groups
GR131_RS07375	COG1657	PFAM Prenyltransferase squalene oxidase
GR131_RS07390	COG3845	ABC transporter
GR131_RS07495	COG0586	Pfam SNARE associated Golgi protein
GR131_RS07510	COG1358	cellular component organization or biogenesis
GR131_RS07560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GR131_RS07580	COG4585	Histidine kinase
GR131_RS07585	COG2197	response regulator
GR131_RS07600	COG0667	Aldo Keto reductase
GR131_RS07605	COG0789	Transcriptional regulator
GR131_RS07620	COG1741	Belongs to the pirin family
GR131_RS07635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR131_RS07640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR131_RS07645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR131_RS07675	COG1764	response to oxidative stress
GR131_RS07680	COG2130	NADP-dependent
GR131_RS07705	COG1077	Cell shape determining protein MreB Mrl
GR131_RS07720	COG2890	protein-(glutamine-N5) methyltransferase activity
GR131_RS07735	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS07785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GR131_RS07795	COG2851	Citrate transporter
GR131_RS07800	COG4565	transcriptional regulatory protein
GR131_RS07805	COG3290	protein histidine kinase activity
GR131_RS07815	COG0358	DNA primase activity
GR131_RS07820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GR131_RS07840	COG1070	Carbohydrate kinase
GR131_RS07880	COG2226	methyltransferase
GR131_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS07910	COG0832	Belongs to the urease beta subunit family
GR131_RS07915	COG0804	urea catabolic process
GR131_RS07920	COG0830	nickel cation binding
GR131_RS07925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GR131_RS07930	COG0829	nickel cation binding
GR131_RS07940	COG1324	tolerance protein
GR131_RS07955	COG0574	Belongs to the PEP-utilizing enzyme family
GR131_RS07955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GR131_RS07990	COG1846	Transcriptional regulator
GR131_RS07990	COG1940	carbohydrate kinase activity
GR131_RS08020	COG3467	pyridoxamine 5'-phosphate
GR131_RS08030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GR131_RS08035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GR131_RS08050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GR131_RS08060	COG0189	ligase activity
GR131_RS08105	COG0423	glycine-tRNA ligase activity
GR131_RS08115	COG1121	(ABC) transporter
GR131_RS08120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GR131_RS08130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GR131_RS08135	COG1381	Involved in DNA repair and RecF pathway recombination
GR131_RS08150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GR131_RS08165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GR131_RS08175	COG2315	Protein conserved in bacteria
GR131_RS08185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GR131_RS08210	COG1486	melibiose metabolic process
GR131_RS08235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR131_RS08240	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GR131_RS08260	COG1234	tRNA 3'-trailer cleavage
GR131_RS08265	COG0537	adenosine 5'-monophosphoramidase activity
GR131_RS08270	COG4946	Tricorn protease homolog
GR131_RS08270	COG0793	Belongs to the peptidase S41A family
GR131_RS08285	COG0484	heat shock protein binding
GR131_RS08320	COG0481	GTPase activity
GR131_RS08325	COG0268	Binds directly to 16S ribosomal RNA
GR131_RS08340	COG2353	YceI-like domain
GR131_RS08350	COG1555	photosystem II stabilization
GR131_RS08355	COG1307	EDD domain protein, DegV family
GR131_RS08365	COG0495	leucyl-tRNA aminoacylation
GR131_RS08390	COG0588	phosphoglycerate mutase activity
GR131_RS08395	COG0799	negative regulation of ribosome biogenesis
GR131_RS08405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GR131_RS08410	COG0501	Belongs to the peptidase M48B family
GR131_RS08430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GR131_RS08440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GR131_RS08460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GR131_RS08465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GR131_RS08470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GR131_RS08475	COG1530	ribonuclease E activity
GR131_RS08500	COG0772	Belongs to the SEDS family
GR131_RS08520	COG1077	Cell shape determining protein MreB Mrl
GR131_RS08525	COG0105	UTP biosynthetic process
GR131_RS08535	COG0285	dihydrofolate synthase activity
GR131_RS08540	COG0525	valine-tRNA ligase activity
GR131_RS08550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GR131_RS08555	COG0740	serine-type endopeptidase activity
GR131_RS08560	COG0740	serine-type endopeptidase activity
GR131_RS08565	COG0544	peptidyl-prolyl cis-trans isomerase activity
GR131_RS08585	COG3594	Acyltransferase
GR131_RS08590	COG0475	glutathione-regulated potassium exporter activity
GR131_RS08600	COG4552	Acetyltransferase involved in intracellular survival and related
GR131_RS08615	COG1113	amino acid transport
GR131_RS08630	COG1073	alpha beta
GR131_RS08640	COG1268	BioY protein
GR131_RS08645	COG1113	amino acid transport
GR131_RS08650	COG1113	amino acid transport
GR131_RS08655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GR131_RS08660	COG0076	glutamate decarboxylase activity
GR131_RS08665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GR131_RS08700	COG4266	Belongs to the allantoicase family
GR131_RS08745	COG0583	DNA-binding transcription factor activity
GR131_RS08765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GR131_RS08780	COG0668	transmembrane transport
GR131_RS08790	COG1486	melibiose metabolic process
GR131_RS08820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR131_RS08850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GR131_RS08855	COG0667	Aldo Keto reductase
GR131_RS08875	COG1136	(ABC) transporter
GR131_RS08960	COG0629	single-stranded DNA binding
GR131_RS09030	COG3629	intracellular signal transduction
GR131_RS09030	COG3903	Transcriptional regulator
GR131_RS09060	COG1131	(ABC) transporter
GR131_RS09075	COG3962	Belongs to the TPP enzyme family
GR131_RS09080	COG3718	enzyme involved in inositol metabolism
GR131_RS09125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GR131_RS09130	COG1472	Belongs to the glycosyl hydrolase 3 family
GR131_RS09150	COG3960	tartronate-semialdehyde synthase activity
GR131_RS09160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR131_RS09200	COG1946	Acyl-CoA thioesterase
GR131_RS09210	COG1309	transcriptional regulator
GR131_RS09215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR131_RS09230	COG1960	acyl-CoA dehydrogenase activity
GR131_RS09245	COG1902	pentaerythritol trinitrate reductase activity
GR131_RS09245	COG0446	pyridine nucleotide-disulphide oxidoreductase
GR131_RS09270	COG3655	Transcriptional regulator
GR131_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS09310	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GR131_RS09335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GR131_RS09350	COG4977	sequence-specific DNA binding
GR131_RS09355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GR131_RS09405	COG2985	domain, Protein
GR131_RS09420	COG0745	RESPONSE REGULATOR receiver
GR131_RS09445	COG0406	alpha-ribazole phosphatase activity
GR131_RS09480	COG0709	Synthesizes selenophosphate from selenide and ATP
GR131_RS09510	COG0012	GTP binding
GR131_RS09525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GR131_RS09530	COG0531	amino acid
GR131_RS09535	COG1570	exodeoxyribonuclease VII activity
GR131_RS09540	COG1722	exodeoxyribonuclease VII activity
GR131_RS09545	COG0778	Nitroreductase
GR131_RS09585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GR131_RS09585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GR131_RS09595	COG0114	fumarate hydratase activity
GR131_RS09605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GR131_RS09620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GR131_RS09640	COG1136	(ABC) transporter
GR131_RS09650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR131_RS09655	COG0450	alkyl hydroperoxide reductase
GR131_RS09675	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GR131_RS09680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GR131_RS09685	COG0667	Aldo Keto reductase
GR131_RS09715	COG3548	integral membrane protein
GR131_RS09730	COG0656	L-ascorbic acid biosynthetic process
GR131_RS09735	COG2814	Major facilitator Superfamily
GR131_RS09800	COG2894	cell division
GR131_RS09835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GR131_RS09935	COG0251	oxidation-reduction process
GR131_RS09940	COG1414	Transcriptional regulator
GR131_RS09955	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GR131_RS09985	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GR131_RS10005	COG1331	Highly conserved protein containing a thioredoxin domain
GR131_RS10015	COG2003	Belongs to the UPF0758 family
GR131_RS10065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GR131_RS10100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GR131_RS10110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GR131_RS10125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GR131_RS10130	COG2255	four-way junction helicase activity
GR131_RS10150	COG2318	DinB family
GR131_RS10155	COG1064	alcohol dehydrogenase
GR131_RS10160	COG1136	(ABC) transporter
GR131_RS10180	COG2986	histidine ammonia-lyase
GR131_RS10190	COG1024	Enoyl-CoA hydratase
GR131_RS10195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GR131_RS10205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR131_RS10215	COG0424	maF-like protein
GR131_RS10225	COG4770	biotin carboxylase activity
GR131_RS10265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GR131_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS10330	COG1595	DNA-templated transcription, initiation
GR131_RS10335	COG0745	RESPONSE REGULATOR receiver
GR131_RS10340	COG2205	protein histidine kinase activity
GR131_RS10365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR131_RS10390	COG0583	DNA-binding transcription factor activity
GR131_RS10395	COG2814	Major facilitator Superfamily
GR131_RS10480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GR131_RS10495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GR131_RS10495	COG1473	amidohydrolase
GR131_RS10505	COG2089	acid synthase
GR131_RS10510	COG1083	cytidylyl-transferase
GR131_RS10520	COG1216	Glycosyl transferase, family 2
GR131_RS10590	COG1595	DNA-templated transcription, initiation
GR131_RS10595	COG1215	transferase activity, transferring glycosyl groups
GR131_RS10635	COG2009	succinate dehydrogenase
GR131_RS10645	COG1053	succinate dehydrogenase
GR131_RS10650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GR131_RS10665	COG1309	transcriptional regulator
GR131_RS10685	COG1408	metallophosphoesterase
GR131_RS10700	COG1295	ribonuclease BN
GR131_RS10745	COG0180	Tryptophanyl-tRNA synthetase
GR131_RS10775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GR131_RS10785	COG0754	glutathionylspermidine amidase activity
GR131_RS10795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR131_RS10800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR131_RS10810	COG1609	Transcriptional regulator
GR131_RS10815	COG2362	D-Aminopeptidase
GR131_RS10835	COG1175	transmembrane transport
GR131_RS10840	COG0395	ABC-type sugar transport system, permease component
GR131_RS10870	COG0517	IMP dehydrogenase activity
GR131_RS10870	COG4175	Glycine betaine
GR131_RS10900	COG0039	L-malate dehydrogenase activity
GR131_RS10935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GR131_RS10945	COG0138	bifunctional purine biosynthesis protein purh
GR131_RS10975	COG0045	succinate-CoA ligase (ADP-forming) activity
GR131_RS10980	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GR131_RS10985	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GR131_RS10990	COG0714	Associated with various cellular activities
GR131_RS11010	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GR131_RS11015	COG0741	lytic transglycosylase activity
GR131_RS11015	COG0739	heme binding
GR131_RS11015	COG1196	nuclear chromosome segregation
GR131_RS11020	COG2066	Belongs to the glutaminase family
GR131_RS11060	COG0791	NLP P60 protein
GR131_RS11080	COG1228	amidohydrolase
GR131_RS11090	COG1846	Transcriptional regulator
GR131_RS11090	COG0456	acetyltransferase
GR131_RS11135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GR131_RS11140	COG2197	response regulator
GR131_RS11180	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS11190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GR131_RS11190	COG0519	Catalyzes the synthesis of GMP from XMP
GR131_RS11210	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS11255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GR131_RS11265	COG0516	GMP reductase activity
GR131_RS11275	COG1595	DNA-templated transcription, initiation
GR131_RS11280	COG2197	response regulator
GR131_RS11290	COG0583	DNA-binding transcription factor activity
GR131_RS11295	COG4221	oxidoreductase activity
GR131_RS11310	COG0726	polysaccharide deacetylase
GR131_RS11345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GR131_RS11370	COG0802	atpase or kinase
GR131_RS11380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GR131_RS11445	COG0736	holo-[acyl-carrier-protein] synthase activity
GR131_RS11460	COG4977	sequence-specific DNA binding
GR131_RS11475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GR131_RS11490	COG1072	(Pantothenic acid kinase))
GR131_RS11495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GR131_RS11500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GR131_RS11505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GR131_RS11515	COG0101	tRNA pseudouridine synthase activity
GR131_RS11520	COG0203	ribosomal protein L17
GR131_RS11530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GR131_RS11535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GR131_RS11540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GR131_RS11545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GR131_RS11555	COG0563	adenylate kinase activity
GR131_RS11560	COG0201	protein transport
GR131_RS11565	COG0200	Binds to the 23S rRNA
GR131_RS11570	COG1841	ribosomal large subunit assembly
GR131_RS11575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GR131_RS11580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GR131_RS11585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GR131_RS11590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GR131_RS11600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GR131_RS11605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GR131_RS11610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GR131_RS11615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GR131_RS11620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GR131_RS11625	COG0255	Belongs to the universal ribosomal protein uL29 family
GR131_RS11630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GR131_RS11635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GR131_RS11640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GR131_RS11645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GR131_RS11650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GR131_RS11655	COG0089	rRNA binding
GR131_RS11660	COG0088	Forms part of the polypeptide exit tunnel
GR131_RS11665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GR131_RS11670	COG0051	transcription antitermination factor activity, RNA binding
GR131_RS11680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GR131_RS11700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GR131_RS11705	COG0049	tRNA binding
GR131_RS11710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GR131_RS11745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GR131_RS11750	COG0085	RNA polymerase activity
GR131_RS11755	COG0222	ribosome binding
GR131_RS11760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GR131_RS11770	COG0081	regulation of translation
GR131_RS11795	COG0436	Aminotransferase
GR131_RS11800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR131_RS11810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GR131_RS11820	COG2030	dehydratase
GR131_RS11825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GR131_RS11840	COG0402	S-adenosylhomocysteine deaminase activity
GR131_RS11845	COG0702	epimerase
GR131_RS11860	COG1666	GTP binding
GR131_RS11865	COG2261	transglycosylase associated protein
GR131_RS11870	COG3304	Inner membrane component domain
GR131_RS11875	COG0501	Belongs to the peptidase M48B family
GR131_RS11880	COG1007	ATP synthesis coupled electron transport
GR131_RS11890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GR131_RS11895	COG0713	ATP synthesis coupled electron transport
GR131_RS11900	COG0839	Belongs to the complex I subunit 6 family
GR131_RS11905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS11910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GR131_RS11915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS11920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS11925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS11935	COG4585	Histidine kinase
GR131_RS11940	COG2197	response regulator
GR131_RS11945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GR131_RS11945	COG0674	pyruvate-flavodoxin oxidoreductase activity
GR131_RS11950	COG1013	pyruvate-flavodoxin oxidoreductase activity
GR131_RS11955	COG1733	regulation of RNA biosynthetic process
GR131_RS11960	COG0702	epimerase
GR131_RS11970	COG0488	(ABC) transporter
GR131_RS11995	COG3104	oligopeptide transport
GR131_RS12020	COG0561	phosphatase activity
GR131_RS12035	COG0514	ATP-dependent DNA helicase (RecQ)
GR131_RS12040	COG1007	ATP synthesis coupled electron transport
GR131_RS12050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GR131_RS12055	COG0713	ATP synthesis coupled electron transport
GR131_RS12060	COG0839	Belongs to the complex I subunit 6 family
GR131_RS12065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS12070	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GR131_RS12075	COG1034	ATP synthesis coupled electron transport
GR131_RS12080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GR131_RS12090	COG0649	NAD binding
GR131_RS12095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS12100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS12125	COG2226	methyltransferase
GR131_RS12135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GR131_RS12185	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GR131_RS12285	COG1674	ftsk spoiiie
GR131_RS12290	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GR131_RS12305	COG0183	Belongs to the thiolase family
GR131_RS12335	COG3559	Exporter of polyketide antibiotics
GR131_RS12340	COG1131	(ABC) transporter
GR131_RS12355	COG1301	dicarboxylic acid transport
GR131_RS12370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GR131_RS12380	COG0163	prenyltransferase activity
GR131_RS12385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GR131_RS12390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GR131_RS12405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GR131_RS12415	COG0785	Cytochrome C biogenesis protein
GR131_RS12420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GR131_RS12430	COG0406	alpha-ribazole phosphatase activity
GR131_RS12435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GR131_RS12485	COG0659	secondary active sulfate transmembrane transporter activity
GR131_RS12490	COG1690	Belongs to the RtcB family
GR131_RS12515	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GR131_RS12520	COG0018	arginyl-trna synthetase
GR131_RS12525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR131_RS12545	COG0113	porphobilinogen synthase activity
GR131_RS12550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GR131_RS12550	COG1648	precorrin-2 dehydrogenase activity
GR131_RS12555	COG0181	hydroxymethylbilane synthase activity
GR131_RS12560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GR131_RS12565	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GR131_RS12575	COG0560	Phosphoserine phosphatase
GR131_RS12590	COG4552	Acetyltransferase involved in intracellular survival and related
GR131_RS12620	COG0123	including yeast histone deacetylase and acetoin utilization protein
GR131_RS12650	COG0180	Tryptophanyl-tRNA synthetase
GR131_RS12655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GR131_RS12665	COG1129	ABC transporter
GR131_RS12665	COG0842	Transport permease protein
GR131_RS12685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GR131_RS12695	COG0129	dihydroxy-acid dehydratase activity
GR131_RS12700	COG1309	transcriptional regulator
GR131_RS12705	COG1082	Xylose isomerase domain protein TIM barrel
GR131_RS12715	COG0248	Ppx GppA phosphatase
GR131_RS12750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GR131_RS12760	COG0671	phosphoesterase, PA-phosphatase related
GR131_RS12770	COG1595	DNA-templated transcription, initiation
GR131_RS12780	COG0745	RESPONSE REGULATOR receiver
GR131_RS12785	COG2205	protein histidine kinase activity
GR131_RS12790	COG0739	heme binding
GR131_RS12800	COG0542	response to heat
GR131_RS12815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GR131_RS12835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GR131_RS12845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GR131_RS12850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GR131_RS12865	COG2197	response regulator
GR131_RS12880	COG0649	NAD binding
GR131_RS12900	COG2197	response regulator
GR131_RS12905	COG4585	Histidine kinase
GR131_RS12920	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS12985	COG0477	Major facilitator Superfamily
GR131_RS13000	COG0477	Major facilitator Superfamily
GR131_RS13010	COG1732	Glycine betaine
GR131_RS13015	COG1174	glycine betaine transport
GR131_RS13020	COG1174	glycine betaine transport
GR131_RS13025	COG0517	IMP dehydrogenase activity
GR131_RS13025	COG1125	glycine betaine transport
GR131_RS13040	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GR131_RS13045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GR131_RS13055	COG0302	gtp cyclohydrolase
GR131_RS13070	COG0037	tRNA processing
GR131_RS13085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GR131_RS13095	COG0586	Pfam SNARE associated Golgi protein
GR131_RS13100	COG0789	Transcriptional regulator
GR131_RS13105	COG0655	NAD(P)H dehydrogenase (quinone) activity
GR131_RS13115	COG2318	DinB family
GR131_RS13120	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS13145	COG1289	transmembrane transporter activity
GR131_RS13185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GR131_RS13185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GR131_RS13190	COG0501	Belongs to the peptidase M48B family
GR131_RS13220	COG2186	Transcriptional regulator
GR131_RS13225	COG2828	Protein conserved in bacteria
GR131_RS13230	COG2159	amidohydrolase
GR131_RS13245	COG2814	Major facilitator Superfamily
GR131_RS13245	COG0477	Major facilitator Superfamily
GR131_RS13260	COG0739	heme binding
GR131_RS13290	COG1609	Transcriptional regulator
GR131_RS13295	COG0588	phosphoglycerate mutase activity
GR131_RS13320	COG0438	transferase activity, transferring glycosyl groups
GR131_RS13330	COG3103	Sh3 type 3 domain protein
GR131_RS13330	COG0791	NLP P60 protein
GR131_RS13330	COG1388	LysM domain
GR131_RS13375	COG2226	methyltransferase
GR131_RS13385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR131_RS13475	COG0789	Transcriptional regulator
GR131_RS13490	COG1490	D-aminoacyl-tRNA deacylase activity
GR131_RS13495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GR131_RS13500	COG0735	belongs to the Fur family
GR131_RS13505	COG3485	protocatechuate 3,4-dioxygenase
GR131_RS13545	COG2897	thiosulfate sulfurtransferase activity
GR131_RS13570	COG0745	RESPONSE REGULATOR receiver
GR131_RS13575	COG1609	Transcriptional regulator
GR131_RS13580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GR131_RS13585	COG0745	RESPONSE REGULATOR receiver
GR131_RS13600	COG4214	carbohydrate transport
GR131_RS13605	COG1129	ABC transporter
GR131_RS13615	COG1609	Transcriptional regulator
GR131_RS13620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR131_RS13650	COG2160	L-arabinose isomerase activity
GR131_RS13655	COG0235	Class ii aldolase
GR131_RS13660	COG0737	Belongs to the 5'-nucleotidase family
GR131_RS13665	COG0456	acetyltransferase
GR131_RS13730	COG4941	Belongs to the sigma-70 factor family
GR131_RS13735	COG1725	Transcriptional regulator
GR131_RS13745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GR131_RS13760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GR131_RS13795	COG2267	carboxylic ester hydrolase activity
GR131_RS13850	COG1595	DNA-templated transcription, initiation
GR131_RS13875	COG2814	Major facilitator Superfamily
GR131_RS13900	COG3903	Transcriptional regulator
GR131_RS13900	COG3629	intracellular signal transduction
GR131_RS13905	COG0596	Alpha beta hydrolase
GR131_RS13915	COG2208	phosphoserine phosphatase activity
GR131_RS13915	COG2770	Histidine kinase
GR131_RS13955	COG2318	DinB family
GR131_RS13960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GR131_RS14010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GR131_RS14015	COG0306	phosphate transporter
GR131_RS14025	COG1937	Protein conserved in bacteria
GR131_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS14045	COG0671	phosphoesterase, PA-phosphatase related
GR131_RS14050	COG0739	heme binding
GR131_RS14050	COG1196	nuclear chromosome segregation
GR131_RS14050	COG0741	lytic transglycosylase activity
GR131_RS14070	COG2318	DinB family
GR131_RS14080	COG0509	glycine decarboxylation via glycine cleavage system
GR131_RS14135	COG0477	Major facilitator Superfamily
GR131_RS14140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GR131_RS14145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GR131_RS14150	COG2124	cytochrome p450
GR131_RS14170	COG0798	PFAM Bile acid sodium symporter
GR131_RS14190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GR131_RS14205	COG1335	isochorismatase
GR131_RS14215	COG2197	response regulator
GR131_RS14220	COG4585	Histidine kinase
GR131_RS14235	COG3844	kynureninase activity
GR131_RS14255	COG0477	Major facilitator Superfamily
GR131_RS14265	COG0191	fructose-bisphosphate aldolase activity
GR131_RS14270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GR131_RS14285	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GR131_RS14315	COG2378	regulation of single-species biofilm formation
GR131_RS14330	COG0477	Major facilitator Superfamily
GR131_RS14355	COG0789	Transcriptional regulator
GR131_RS14360	COG0484	heat shock protein binding
GR131_RS14365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GR131_RS14370	COG0443	Heat shock 70 kDa protein
GR131_RS14405	COG1725	Transcriptional regulator
GR131_RS14410	COG1131	(ABC) transporter
GR131_RS14440	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GR131_RS14445	COG1404	Belongs to the peptidase S8 family
GR131_RS14450	COG1120	ATPase activity
GR131_RS14455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS14460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS14495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR131_RS14495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR131_RS14525	COG1695	Transcriptional regulator
GR131_RS14535	COG2814	Major facilitator Superfamily
GR131_RS14585	COG0717	Belongs to the dCTP deaminase family
GR131_RS14615	COG0247	lactate metabolic process
GR131_RS14615	COG2181	nitrate reductase activity
GR131_RS14645	COG0477	Major facilitator Superfamily
GR131_RS14665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR131_RS14700	COG1064	alcohol dehydrogenase
GR131_RS14705	COG1937	Protein conserved in bacteria
GR131_RS14710	COG2268	Band 7 protein
GR131_RS14725	COG1316	TRANSCRIPTIONal
GR131_RS14765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR131_RS14775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GR131_RS14785	COG0628	permease
GR131_RS14790	COG1741	Belongs to the pirin family
GR131_RS14800	COG1960	acyl-CoA dehydrogenase activity
GR131_RS14820	COG1362	aminopeptidase activity
GR131_RS14875	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR131_RS14880	COG0022	dehydrogenase e1 component
GR131_RS14895	COG0515	serine threonine protein kinase
GR131_RS14900	COG0515	serine threonine protein kinase
GR131_RS14925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GR131_RS14930	COG0303	'Molybdopterin
GR131_RS14955	COG1522	sequence-specific DNA binding
GR131_RS14995	COG1733	regulation of RNA biosynthetic process
GR131_RS15000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GR131_RS15010	COG1716	ATPase activity
GR131_RS15015	COG1716	ATPase activity
GR131_RS15035	COG0515	serine threonine protein kinase
GR131_RS15040	COG3764	Sortase (surface protein transpeptidase)
GR131_RS15045	COG3764	Sortase (surface protein transpeptidase)
GR131_RS15070	COG0705	Rhomboid family
GR131_RS15090	COG1309	transcriptional regulator
GR131_RS15105	COG0515	serine threonine protein kinase
GR131_RS15145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GR131_RS15150	COG0187	DNA topoisomerase II activity
GR131_RS15155	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GR131_RS15160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GR131_RS15165	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GR131_RS15170	COG0592	DNA-directed DNA polymerase activity
GR131_RS15175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GR131_RS15180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GR131_RS15185	COG0594	ribonuclease P activity
GR131_RS15190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GR131_RS15195	COG0706	membrane insertase activity
GR131_RS15205	COG0357	Ribosomal RNA small subunit methyltransferase G
GR131_RS15210	COG1192	Involved in chromosome partitioning
GR131_RS15225	COG3118	belongs to the thioredoxin family
GR131_RS15230	COG0492	ferredoxin-NADP+ reductase activity
GR131_RS15240	COG1595	DNA-templated transcription, initiation
GR131_RS15245	COG2815	serine threonine protein kinase
GR131_RS15245	COG0515	serine threonine protein kinase
GR131_RS15260	COG0617	tRNA 3'-terminal CCA addition
GR131_RS15285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GR131_RS15310	COG0360	Binds together with S18 to 16S ribosomal RNA
GR131_RS15315	COG0629	single-stranded DNA binding
GR131_RS15320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GR131_RS15325	COG0359	binds to the 23S rRNA
GR131_RS15335	COG0305	Participates in initiation and elongation during chromosome replication
GR131_RS15340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GR131_RS15345	COG0110	maltose O-acetyltransferase activity
GR131_RS15390	COG0626	cystathionine gamma-synthase activity
GR131_RS15395	COG1950	PFAM Membrane protein of
GR131_RS15400	COG0662	Cupin 2, conserved barrel domain protein
GR131_RS15425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GR131_RS15440	COG1609	Transcriptional regulator
GR131_RS15445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GR131_RS15450	COG1271	oxidase subunit
GR131_RS15455	COG1294	oxidase, subunit
GR131_RS15460	COG4988	ABC transporter
GR131_RS15470	COG0739	heme binding
GR131_RS15470	COG1196	nuclear chromosome segregation
GR131_RS15470	COG0741	lytic transglycosylase activity
GR131_RS15475	COG0561	phosphatase activity
GR131_RS15495	COG1131	(ABC) transporter
GR131_RS15515	COG0561	phosphatase activity
GR131_RS15520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GR131_RS15525	COG0077	Prephenate dehydratase
GR131_RS15530	COG2837	iron assimilation
GR131_RS15545	COG1999	signal sequence binding
GR131_RS15565	COG0006	proline dipeptidase activity
GR131_RS15580	COG0653	protein targeting
GR131_RS15595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GR131_RS15615	COG1595	DNA-templated transcription, initiation
GR131_RS15620	COG0318	PFAM AMP-dependent synthetase and ligase
GR131_RS15645	COG0582	viral genome integration into host DNA
GR131_RS15685	COG1725	Transcriptional regulator
GR131_RS15710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GR131_RS15725	COG0494	nUDIX hydrolase
GR131_RS15730	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GR131_RS15735	COG0732	type I restriction modification DNA specificity domain
GR131_RS15740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GR131_RS15760	COG0745	RESPONSE REGULATOR receiver
GR131_RS15770	COG0477	Major facilitator Superfamily
GR131_RS15790	COG0477	Major facilitator Superfamily
GR131_RS15795	COG1846	Transcriptional regulator
GR131_RS15805	COG1191	sigma factor activity
GR131_RS15810	COG1191	sigma factor activity
GR131_RS15825	COG0590	tRNA wobble adenosine to inosine editing
GR131_RS15840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GR131_RS15900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GR131_RS15905	COG2837	iron assimilation
GR131_RS15915	COG0659	secondary active sulfate transmembrane transporter activity
GR131_RS15940	COG0151	Belongs to the GarS family
GR131_RS15955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GR131_RS15965	COG2197	response regulator
GR131_RS16000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GR131_RS16005	COG0047	phosphoribosylformylglycinamidine synthase activity
GR131_RS16010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GR131_RS16025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GR131_RS16065	COG1643	Atp-dependent helicase
GR131_RS16100	COG0513	Belongs to the DEAD box helicase family
GR131_RS16115	COG3620	sequence-specific DNA binding
GR131_RS16335	COG1061	Type III restriction enzyme res subunit
GR131_RS16395	COG0542	response to heat
GR131_RS16425	COG0667	Aldo Keto reductase
GR131_RS16435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GR131_RS16440	COG0579	oxidoreductase
GR131_RS16455	COG0366	Alpha amylase catalytic
GR131_RS16455	COG1470	cell adhesion involved in biofilm formation
GR131_RS16540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GR131_RS16600	COG2197	response regulator
GR131_RS16615	COG0666	response to abiotic stimulus
GR131_RS16625	COG1733	regulation of RNA biosynthetic process
GR131_RS16685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GR131_RS16690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GR131_RS16735	COG2130	NADP-dependent
GR131_RS16780	COG2318	DinB family
GR131_RS16810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GR131_RS16825	COG0270	DNA (cytosine-5-)-methyltransferase activity
GR131_RS16835	COG1408	metallophosphoesterase
GR131_RS16855	COG0003	Pfam Anion-transporting ATPase
GR131_RS16865	COG0251	oxidation-reduction process
GR131_RS16875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GR131_RS16905	COG2267	carboxylic ester hydrolase activity
GR131_RS16915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GR131_RS16920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GR131_RS16925	COG0659	secondary active sulfate transmembrane transporter activity
GR131_RS16985	COG1205	dead DEAH box helicase
GR131_RS16985	COG1111	helicase
GR131_RS16990	COG1366	Belongs to the anti-sigma-factor antagonist family
GR131_RS17005	COG2890	protein-(glutamine-N5) methyltransferase activity
GR131_RS17015	COG1754	DNA topoisomerase type I activity
GR131_RS17015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GR131_RS17020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GR131_RS17050	COG0789	Transcriptional regulator
GR131_RS17065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GR131_RS17070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GR131_RS17085	COG0789	Transcriptional regulator
GR131_RS17095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GR131_RS17095	COG0825	malonyl-CoA metabolic process
GR131_RS17100	COG0318	PFAM AMP-dependent synthetase and ligase
GR131_RS17110	COG2186	Transcriptional regulator
GR131_RS17130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GR131_RS17140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GR131_RS17150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR131_RS17200	COG4106	trans-aconitate 2-methyltransferase activity
GR131_RS17205	COG1252	NADH dehydrogenase
GR131_RS17215	COG0640	Transcriptional regulator
GR131_RS17225	COG1316	TRANSCRIPTIONal
GR131_RS17230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GR131_RS17245	COG0793	Belongs to the peptidase S41A family
GR131_RS17250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GR131_RS17265	COG5001	Diguanylate cyclase
GR131_RS17285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS17290	COG1120	ATPase activity
GR131_RS17295	COG0783	Belongs to the Dps family
GR131_RS17330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GR131_RS17335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GR131_RS17355	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GR131_RS17395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GR131_RS17475	COG2076	Multidrug Resistance protein
GR131_RS17485	COG5002	protein histidine kinase activity
GR131_RS17490	COG0745	RESPONSE REGULATOR receiver
GR131_RS17505	COG1329	Transcriptional regulator
GR131_RS17510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GR131_RS17515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GR131_RS17535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR131_RS17550	COG0215	cysteine-tRNA ligase activity
GR131_RS17565	COG1253	flavin adenine dinucleotide binding
GR131_RS17575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GR131_RS17585	COG3842	ATPase activity
GR131_RS17595	COG2814	Major facilitator Superfamily
GR131_RS17630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GR131_RS17630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR131_RS17640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR131_RS17640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR131_RS17650	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GR131_RS17660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GR131_RS17665	COG1733	regulation of RNA biosynthetic process
GR131_RS17670	COG0436	Aminotransferase
GR131_RS17680	COG0456	acetyltransferase
GR131_RS17715	COG2208	phosphoserine phosphatase activity
GR131_RS17715	COG2770	Histidine kinase
GR131_RS17745	COG1278	Cold shock
GR131_RS17750	COG0513	Belongs to the DEAD box helicase family
GR131_RS17770	COG0301	tRNA thio-modification
GR131_RS17790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GR131_RS17795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GR131_RS17800	COG2197	response regulator
GR131_RS17805	COG4585	Histidine kinase
GR131_RS17840	COG1902	pentaerythritol trinitrate reductase activity
GR131_RS17850	COG0577	efflux transmembrane transporter activity
GR131_RS17855	COG0577	efflux transmembrane transporter activity
GR131_RS17855	COG1136	(ABC) transporter
GR131_RS17880	COG2172	sigma factor antagonist activity
GR131_RS17885	COG1366	Belongs to the anti-sigma-factor antagonist family
GR131_RS17890	COG1366	Belongs to the anti-sigma-factor antagonist family
GR131_RS17965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GR131_RS18035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR131_RS18095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GR131_RS18120	COG1105	Belongs to the carbohydrate kinase PfkB family
GR131_RS18155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GR131_RS18180	COG0463	Glycosyl transferase, family 2
GR131_RS18240	COG0667	Aldo Keto reductase
GR131_RS18245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GR131_RS18245	COG1263	PTS System
GR131_RS18250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GR131_RS18255	COG1737	Transcriptional regulator
GR131_RS18265	COG0406	alpha-ribazole phosphatase activity
GR131_RS18300	COG2197	response regulator
GR131_RS18330	COG3142	Participates in the control of copper homeostasis
GR131_RS18350	COG3973	AAA domain
GR131_RS18385	COG0789	Transcriptional regulator
GR131_RS18390	COG0667	Aldo Keto reductase
GR131_RS18425	COG1061	Type III restriction enzyme res subunit
GR131_RS18475	COG2124	cytochrome p450
GR131_RS18485	COG1295	ribonuclease BN
GR131_RS18495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS18500	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS18505	COG1120	ATPase activity
GR131_RS18510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GR131_RS18515	COG0515	serine threonine protein kinase
GR131_RS18525	COG1132	(ABC) transporter
GR131_RS18530	COG1132	(ABC) transporter
GR131_RS18535	COG2197	response regulator
GR131_RS18545	COG1278	Cold shock
GR131_RS18550	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GR131_RS18555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GR131_RS18565	COG2814	Major facilitator Superfamily
GR131_RS18590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GR131_RS18600	COG2252	PERMEase
GR131_RS18625	COG0667	Aldo Keto reductase
GR131_RS18705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GR131_RS18715	COG2124	cytochrome p450
GR131_RS18735	COG2205	protein histidine kinase activity
GR131_RS18740	COG0277	FAD linked oxidase domain protein
GR131_RS18740	COG0247	lactate metabolic process
GR131_RS18750	COG0583	DNA-binding transcription factor activity
GR131_RS18805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR131_RS18820	COG1024	Enoyl-CoA hydratase
GR131_RS18845	COG0259	pyridoxamine-phosphate oxidase activity
GR131_RS18855	COG4821	SIS domain
GR131_RS18940	COG1366	Belongs to the anti-sigma-factor antagonist family
GR131_RS18960	COG2271	Major facilitator Superfamily
GR131_RS18965	COG2072	flavoprotein involved in K transport
GR131_RS18985	COG1309	transcriptional regulator
GR131_RS18990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GR131_RS18990	COG0515	serine threonine protein kinase
GR131_RS19025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GR131_RS19055	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GR131_RS19085	COG5297	Belongs to the glycosyl hydrolase family 6
GR131_RS19170	COG1278	Cold shock
GR131_RS19185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GR131_RS19200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GR131_RS19220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GR131_RS19225	COG2151	metal-sulfur cluster biosynthetic enzyme
GR131_RS19230	COG3396	Phenylacetate-CoA oxygenase
GR131_RS19235	COG3460	Phenylacetate-CoA oxygenase
GR131_RS19240	COG3396	Phenylacetate-CoA oxygenase
GR131_RS19245	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS19250	COG1024	Enoyl-CoA hydratase
GR131_RS19255	COG0183	Belongs to the thiolase family
GR131_RS19265	COG2050	protein possibly involved in aromatic compounds catabolism
GR131_RS19320	COG1846	Transcriptional regulator
GR131_RS19325	COG3384	dioxygenase
GR131_RS19345	COG3191	aminopeptidase activity
GR131_RS19360	COG1970	mechanosensitive ion channel activity
GR131_RS19370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GR131_RS19385	COG3263	regulation of cellular component size
GR131_RS19395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GR131_RS19400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GR131_RS19410	COG0315	cyclic pyranopterin monophosphate synthase activity
GR131_RS19415	COG0521	Mo-molybdopterin cofactor biosynthetic process
GR131_RS19415	COG0315	cyclic pyranopterin monophosphate synthase activity
GR131_RS19455	COG2197	response regulator
GR131_RS19465	COG0596	Alpha beta hydrolase
GR131_RS19475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GR131_RS19485	COG0708	Exodeoxyribonuclease III
GR131_RS19495	COG2072	flavoprotein involved in K transport
GR131_RS19505	COG4221	oxidoreductase activity
GR131_RS19515	COG0793	Belongs to the peptidase S41A family
GR131_RS19515	COG4946	Tricorn protease homolog
GR131_RS19525	COG2409	Drug exporters of the RND superfamily
GR131_RS19600	COG0084	hydrolase, TatD family'
GR131_RS19605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GR131_RS19610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GR131_RS19615	COG0488	(ABC) transporter
GR131_RS19660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GR131_RS19665	COG2197	response regulator
GR131_RS19670	COG1846	Transcriptional regulator
GR131_RS19675	COG4106	trans-aconitate 2-methyltransferase activity
GR131_RS19685	COG1309	transcriptional regulator
GR131_RS19695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GR131_RS19705	COG0193	aminoacyl-tRNA hydrolase activity
GR131_RS19710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GR131_RS19735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GR131_RS19740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GR131_RS19750	COG4585	Histidine kinase
GR131_RS19775	COG0789	Transcriptional regulator
GR131_RS19795	COG1316	TRANSCRIPTIONal
GR131_RS19805	COG0596	Alpha beta hydrolase
GR131_RS19835	COG0477	Major facilitator Superfamily
GR131_RS19845	COG3629	intracellular signal transduction
GR131_RS19845	COG3903	Transcriptional regulator
GR131_RS19900	COG1473	amidohydrolase
GR131_RS19910	COG3226	Transcriptional regulator
GR131_RS19915	COG0154	amidase activity
GR131_RS19955	COG1733	regulation of RNA biosynthetic process
GR131_RS19995	COG2124	cytochrome p450
GR131_RS20010	COG0148	phosphopyruvate hydratase activity
GR131_RS20040	COG1252	NADH dehydrogenase
GR131_RS20045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GR131_RS20050	COG1136	(ABC) transporter
GR131_RS20050	COG0577	efflux transmembrane transporter activity
GR131_RS20055	COG1136	(ABC) transporter
GR131_RS20065	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GR131_RS20080	COG1476	TRANSCRIPTIONal
GR131_RS20100	COG0183	Belongs to the thiolase family
GR131_RS20165	COG0395	ABC-type sugar transport system, permease component
GR131_RS20185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR131_RS20195	COG1228	amidohydrolase
GR131_RS20200	COG1191	sigma factor activity
GR131_RS20205	COG1366	Belongs to the anti-sigma-factor antagonist family
GR131_RS20215	COG3104	oligopeptide transport
GR131_RS20220	COG0745	RESPONSE REGULATOR receiver
GR131_RS20225	COG2205	protein histidine kinase activity
GR131_RS20240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GR131_RS20265	COG2072	flavoprotein involved in K transport
GR131_RS20275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GR131_RS20305	COG0753	catalase activity
GR131_RS20355	COG3046	protein related to deoxyribodipyrimidine photolyase
GR131_RS20360	COG1316	TRANSCRIPTIONal
GR131_RS20380	COG1316	TRANSCRIPTIONal
GR131_RS20410	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GR131_RS20410	COG0778	Nitroreductase
GR131_RS20450	COG1620	l-lactate permease
GR131_RS20460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GR131_RS20470	COG2835	tetraacyldisaccharide 4'-kinase activity
GR131_RS20480	COG1482	cell wall glycoprotein biosynthetic process
GR131_RS20490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GR131_RS20525	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GR131_RS20530	COG0714	Associated with various cellular activities
GR131_RS20550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GR131_RS20555	COG0745	RESPONSE REGULATOR receiver
GR131_RS20560	COG5002	protein histidine kinase activity
GR131_RS20565	COG0823	Involved in the tonB-independent uptake of proteins
GR131_RS20575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GR131_RS20580	COG2197	response regulator
GR131_RS20585	COG3214	Protein conserved in bacteria
GR131_RS20590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR131_RS20595	COG0653	protein targeting
GR131_RS20610	COG0583	DNA-binding transcription factor activity
GR131_RS20630	COG2902	Dehydrogenase
GR131_RS20645	COG2226	methyltransferase
GR131_RS20655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GR131_RS20660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GR131_RS20665	COG0438	transferase activity, transferring glycosyl groups
GR131_RS20670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GR131_RS20675	COG0395	ABC-type sugar transport system, permease component
GR131_RS20690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GR131_RS20695	COG1716	ATPase activity
GR131_RS20700	COG0515	serine threonine protein kinase
GR131_RS20705	COG0515	serine threonine protein kinase
GR131_RS20710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GR131_RS20725	COG2884	Cell division ATP-binding protein ftsE
GR131_RS20735	COG0793	Belongs to the peptidase S41A family
GR131_RS20740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GR131_RS20755	COG0583	DNA-binding transcription factor activity
GR131_RS20800	COG3973	AAA domain
GR131_RS20810	COG0776	regulation of translation
GR131_RS20815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GR131_RS20820	COG1678	Uncharacterized ACR, COG1678
GR131_RS20835	COG1175	transmembrane transport
GR131_RS20840	COG0395	ABC-type sugar transport system, permease component
GR131_RS20845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GR131_RS20860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR131_RS20885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GR131_RS20910	COG2318	DinB family
GR131_RS20925	COG1116	anion transmembrane transporter activity
GR131_RS20970	COG1174	glycine betaine transport
GR131_RS20975	COG0517	IMP dehydrogenase activity
GR131_RS20975	COG1125	glycine betaine transport
GR131_RS20980	COG1174	glycine betaine transport
GR131_RS20990	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GR131_RS21000	COG0277	FAD linked oxidase domain protein
GR131_RS21025	COG4412	M6 family metalloprotease domain protein
GR131_RS21025	COG3291	Pkd domain containing protein
GR131_RS21035	COG2205	protein histidine kinase activity
GR131_RS21040	COG0745	RESPONSE REGULATOR receiver
GR131_RS21070	COG1335	isochorismatase
GR131_RS21080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GR131_RS21095	COG1113	amino acid transport
GR131_RS21115	COG1234	tRNA 3'-trailer cleavage
GR131_RS21125	COG1263	PTS System
GR131_RS21125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GR131_RS21130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GR131_RS21130	COG1263	PTS System
GR131_RS21135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GR131_RS21145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GR131_RS21170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GR131_RS21180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GR131_RS21210	COG2733	membrane
GR131_RS21240	COG0706	membrane insertase activity
GR131_RS21250	COG0673	inositol 2-dehydrogenase activity
GR131_RS21305	COG3397	chitin binding
GR131_RS21335	COG1126	abc transporter atp-binding protein
GR131_RS21340	COG0765	amino acid transport
GR131_RS21345	COG0765	amino acid transport
GR131_RS21350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR131_RS21370	COG3473	Maleate cis-trans isomerase
GR131_RS21380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS21385	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS21505	COG0747	negative chemotaxis
GR131_RS21510	COG0601	transmembrane transport
GR131_RS21515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR131_RS21520	COG0444	Belongs to the ABC transporter superfamily
GR131_RS21525	COG4608	Belongs to the ABC transporter superfamily
GR131_RS21535	COG0601	transmembrane transport
GR131_RS21540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR131_RS21550	COG4608	Belongs to the ABC transporter superfamily
GR131_RS21575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GR131_RS21600	COG1879	ABC-type sugar transport system periplasmic component
GR131_RS21605	COG1129	ABC transporter
GR131_RS21615	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR131_RS21620	COG1609	Transcriptional regulator
GR131_RS21630	COG2912	Transglutaminase-like superfamily
GR131_RS21635	COG0456	acetyltransferase
GR131_RS21665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR131_RS21700	COG0519	Catalyzes the synthesis of GMP from XMP
GR131_RS21710	COG1024	Enoyl-CoA hydratase
GR131_RS21725	COG1595	DNA-templated transcription, initiation
GR131_RS21735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GR131_RS21740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GR131_RS21780	COG0598	Magnesium transport protein CorA
GR131_RS21790	COG2814	Major facilitator Superfamily
GR131_RS21795	COG0613	PHP domain protein
GR131_RS21800	COG2095	MarC family integral membrane protein
GR131_RS21805	COG1432	Conserved Protein
GR131_RS21815	COG0513	Belongs to the DEAD box helicase family
GR131_RS21910	COG0210	DNA helicase
GR131_RS21915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR131_RS21950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GR131_RS22005	COG3480	Lon protease (S16) C-terminal proteolytic domain
GR131_RS22015	COG1615	UPF0182 protein
GR131_RS22040	COG0753	catalase activity
GR131_RS22045	COG0483	inositol monophosphate 1-phosphatase activity
GR131_RS22055	COG2076	Multidrug Resistance protein
GR131_RS22065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GR131_RS22075	COG2135	peptidase activity
GR131_RS22085	COG1595	DNA-templated transcription, initiation
GR131_RS22090	COG5662	AntiSigma factor
GR131_RS22100	COG0242	peptide deformylase activity
GR131_RS22110	COG2124	cytochrome p450
GR131_RS22130	COG1966	Carbon starvation protein
GR131_RS22135	COG2188	Transcriptional regulator
GR131_RS22145	COG1175	transmembrane transport
GR131_RS22155	COG1472	Belongs to the glycosyl hydrolase 3 family
GR131_RS22160	COG0363	glucosamine-6-phosphate deaminase activity
GR131_RS22175	COG1597	lipid kinase activity
GR131_RS22190	COG2172	sigma factor antagonist activity
GR131_RS22205	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GR131_RS22220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GR131_RS22220	COG1017	nitric oxide dioxygenase activity
GR131_RS22225	COG1959	2 iron, 2 sulfur cluster binding
GR131_RS22230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR131_RS22290	COG4106	trans-aconitate 2-methyltransferase activity
GR131_RS22295	COG1126	abc transporter atp-binding protein
GR131_RS22310	COG0281	malic enzyme
GR131_RS22315	COG0604	alcohol dehydrogenase
GR131_RS22355	COG2255	four-way junction helicase activity
GR131_RS22385	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR131_RS22385	COG0567	Dehydrogenase, E1 component
GR131_RS22390	COG2205	protein histidine kinase activity
GR131_RS22395	COG0745	RESPONSE REGULATOR receiver
GR131_RS22415	COG1131	(ABC) transporter
GR131_RS22425	COG1595	DNA-templated transcription, initiation
GR131_RS22440	COG0477	Major facilitator Superfamily
GR131_RS22445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GR131_RS22450	COG0726	polysaccharide deacetylase
GR131_RS22525	COG0772	Belongs to the SEDS family
GR131_RS22540	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GR131_RS22545	COG2267	carboxylic ester hydrolase activity
GR131_RS22555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GR131_RS22555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GR131_RS22560	COG1191	sigma factor activity
GR131_RS22570	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS22605	COG0018	arginyl-trna synthetase
GR131_RS22610	COG0019	diaminopimelate decarboxylase activity
GR131_RS22615	COG0460	homoserine dehydrogenase
GR131_RS22620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GR131_RS22625	COG0083	homoserine kinase activity
GR131_RS22635	COG1316	TRANSCRIPTIONal
GR131_RS22640	COG0254	rRNA binding
GR131_RS22645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GR131_RS22650	COG2890	protein-(glutamine-N5) methyltransferase activity
GR131_RS22660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GR131_RS22665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GR131_RS22680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GR131_RS22685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GR131_RS22690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GR131_RS22695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GR131_RS22700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GR131_RS22705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GR131_RS22710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GR131_RS22730	COG2197	response regulator
GR131_RS22735	COG4585	Histidine kinase
GR131_RS22750	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS22765	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GR131_RS22800	COG1131	(ABC) transporter
GR131_RS22820	COG0183	Belongs to the thiolase family
GR131_RS22850	COG1335	isochorismatase
GR131_RS22970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GR131_RS22975	COG0857	belongs to the CobB CobQ family
GR131_RS22975	COG0280	phosphate acetyltransferase
GR131_RS22980	COG0205	6-phosphofructokinase activity
GR131_RS22985	COG4565	transcriptional regulatory protein
GR131_RS22990	COG3290	protein histidine kinase activity
GR131_RS22995	COG1301	dicarboxylic acid transport
GR131_RS23010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GR131_RS23015	COG1119	ATPase activity
GR131_RS23030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GR131_RS23035	COG3281	Trehalose synthase
GR131_RS23040	COG0366	Alpha amylase catalytic
GR131_RS23045	COG0366	Alpha amylase catalytic
GR131_RS23065	COG1733	regulation of RNA biosynthetic process
GR131_RS23075	COG1132	(ABC) transporter
GR131_RS23080	COG1132	(ABC) transporter
GR131_RS23105	COG1376	ErfK ybiS ycfS ynhG family protein
GR131_RS23130	COG2085	NADP oxidoreductase coenzyme F420-dependent
GR131_RS23155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR131_RS23170	COG0477	Major facilitator Superfamily
GR131_RS23185	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GR131_RS23190	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GR131_RS23195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GR131_RS23215	COG1760	l-serine dehydratase
GR131_RS23220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GR131_RS23225	COG0509	glycine decarboxylation via glycine cleavage system
GR131_RS23230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GR131_RS23250	COG0747	negative chemotaxis
GR131_RS23265	COG0444	Belongs to the ABC transporter superfamily
GR131_RS23270	COG4608	Belongs to the ABC transporter superfamily
GR131_RS23275	COG2860	membrane
GR131_RS23300	COG0482	sulfurtransferase activity
GR131_RS23320	COG4221	oxidoreductase activity
GR131_RS23330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GR131_RS23340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GR131_RS23345	COG0154	amidase activity
GR131_RS23355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GR131_RS23360	COG2409	Drug exporters of the RND superfamily
GR131_RS23375	COG2197	response regulator
GR131_RS23380	COG3293	Transposase
GR131_RS23390	COG2133	pyrroloquinoline quinone binding
GR131_RS23395	COG0667	Aldo Keto reductase
GR131_RS23415	COG0440	acetolactate synthase activity
GR131_RS23420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GR131_RS23430	COG2890	protein-(glutamine-N5) methyltransferase activity
GR131_RS23450	COG3835	regulator
GR131_RS23455	COG0506	proline dehydrogenase activity
GR131_RS23460	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS23485	COG0473	3-isopropylmalate dehydrogenase activity
GR131_RS23490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GR131_RS23495	COG0831	urea catabolic process
GR131_RS23495	COG0832	Belongs to the urease beta subunit family
GR131_RS23500	COG0804	urea catabolic process
GR131_RS23505	COG2957	Belongs to the agmatine deiminase family
GR131_RS23510	COG0477	Major facilitator Superfamily
GR131_RS23515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GR131_RS23545	COG4221	oxidoreductase activity
GR131_RS23565	COG0789	Transcriptional regulator
GR131_RS23610	COG2353	YceI-like domain
GR131_RS23620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR131_RS23640	COG2018	Roadblock/LC7 domain
GR131_RS23665	COG2018	Roadblock/LC7 domain
GR131_RS23680	COG0179	Fumarylacetoacetate (FAA) hydrolase
GR131_RS23685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GR131_RS23730	COG1414	Transcriptional regulator
GR131_RS23735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GR131_RS23740	COG0066	3-isopropylmalate dehydratase activity
GR131_RS23750	COG0776	regulation of translation
GR131_RS23770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GR131_RS23775	COG1181	Belongs to the D-alanine--D-alanine ligase family
GR131_RS23795	COG0351	phosphomethylpyrimidine kinase
GR131_RS23800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GR131_RS23805	COG1461	Dihydroxyacetone kinase
GR131_RS23815	COG0742	ribosomal rna small subunit methyltransferase
GR131_RS23820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GR131_RS23835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GR131_RS23840	COG0571	ribonuclease III activity
GR131_RS23845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GR131_RS23880	COG2340	Cysteine-rich secretory protein family
GR131_RS23885	COG1254	Belongs to the acylphosphatase family
GR131_RS23895	COG1196	nuclear chromosome segregation
GR131_RS23900	COG0477	Major facilitator Superfamily
GR131_RS23930	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GR131_RS23940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GR131_RS23955	COG0228	four-way junction DNA binding
GR131_RS23960	COG1837	Belongs to the UPF0109 family
GR131_RS23965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GR131_RS23970	COG0336	Belongs to the RNA methyltransferase TrmD family
GR131_RS23975	COG0335	large ribosomal subunit rRNA binding
GR131_RS23980	COG0681	Belongs to the peptidase S26 family
GR131_RS23985	COG0681	Belongs to the peptidase S26 family
GR131_RS23990	COG0681	Belongs to the peptidase S26 family
GR131_RS23995	COG0681	Belongs to the peptidase S26 family
GR131_RS24000	COG1051	belongs to the nudix hydrolase family
GR131_RS24010	COG0792	nuclease activity
GR131_RS24015	COG0606	chelatase, subunit chli
GR131_RS24025	COG1191	sigma factor activity
GR131_RS24040	COG0052	Belongs to the universal ribosomal protein uS2 family
GR131_RS24045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GR131_RS24050	COG0528	UMP kinase activity
GR131_RS24055	COG0233	cytoplasmic translational termination
GR131_RS24060	COG0575	Belongs to the CDS family
GR131_RS24065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GR131_RS24075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GR131_RS24080	COG3842	ATPase activity
GR131_RS24100	COG1136	(ABC) transporter
GR131_RS24105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GR131_RS24115	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS24120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GR131_RS24135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR131_RS24150	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS24160	COG3842	ATPase activity
GR131_RS24165	COG1176	ABC-type spermidine putrescine transport system, permease component I
GR131_RS24170	COG1177	transmembrane transport
GR131_RS24175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR131_RS24205	COG2508	Transcriptional regulator
GR131_RS24210	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS24215	COG1940	carbohydrate kinase activity
GR131_RS24220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GR131_RS24225	COG0750	zinc metalloprotease
GR131_RS24230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GR131_RS24245	COG0747	negative chemotaxis
GR131_RS24250	COG0601	transmembrane transport
GR131_RS24275	COG0442	prolyl-tRNA aminoacylation
GR131_RS24295	COG0779	Required for maturation of 30S ribosomal subunits
GR131_RS24310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GR131_RS24320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GR131_RS24325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GR131_RS24340	COG1357	PFAM Pentapeptide repeats (8 copies)
GR131_RS24345	COG4608	Belongs to the ABC transporter superfamily
GR131_RS24350	COG0444	Belongs to the ABC transporter superfamily
GR131_RS24355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR131_RS24360	COG0601	transmembrane transport
GR131_RS24365	COG0747	negative chemotaxis
GR131_RS24370	COG0455	bacterial-type flagellum organization
GR131_RS24380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GR131_RS24385	COG1185	polyribonucleotide nucleotidyltransferase activity
GR131_RS24390	COG0612	Peptidase, M16
GR131_RS24395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GR131_RS24415	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GR131_RS24420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GR131_RS24425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GR131_RS24455	COG2770	Histidine kinase
GR131_RS24455	COG2208	phosphoserine phosphatase activity
GR131_RS24460	COG3850	Histidine kinase
GR131_RS24460	COG2205	protein histidine kinase activity
GR131_RS24460	COG4999	Histidine kinase
GR131_RS24460	COG3437	response regulator, receiver
GR131_RS24470	COG1674	ftsk spoiiie
GR131_RS24480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GR131_RS24490	COG1546	Belongs to the CinA family
GR131_RS24490	COG1058	Belongs to the CinA family
GR131_RS24495	COG1396	sequence-specific DNA binding
GR131_RS24500	COG0783	Belongs to the Dps family
GR131_RS24510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GR131_RS24530	COG0596	Alpha beta hydrolase
GR131_RS24535	COG1201	RNA secondary structure unwinding
GR131_RS24560	COG0628	permease
GR131_RS24585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GR131_RS24590	COG2137	regulation of response to DNA damage stimulus
GR131_RS24595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GR131_RS24605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR131_RS24610	COG0765	amino acid transport
GR131_RS24615	COG0765	amino acid transport
GR131_RS24620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR131_RS24625	COG1126	abc transporter atp-binding protein
GR131_RS24630	COG0745	RESPONSE REGULATOR receiver
GR131_RS24635	COG2205	protein histidine kinase activity
GR131_RS24645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GR131_RS24665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GR131_RS24675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GR131_RS24680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GR131_RS24690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GR131_RS24735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GR131_RS24740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GR131_RS24760	COG0588	phosphoglycerate mutase activity
GR131_RS24775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GR131_RS24810	COG1802	Transcriptional regulator
GR131_RS24815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GR131_RS24830	COG0187	DNA topoisomerase II activity
GR131_RS24850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR131_RS24865	COG1653	transport
GR131_RS24870	COG1175	transmembrane transport
GR131_RS24875	COG0395	ABC-type sugar transport system, permease component
GR131_RS24880	COG0366	Alpha amylase catalytic
GR131_RS24890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GR131_RS24895	COG0612	Peptidase, M16
GR131_RS24905	COG0739	heme binding
GR131_RS24910	COG1802	Transcriptional regulator
GR131_RS24915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GR131_RS24970	COG0483	inositol monophosphate 1-phosphatase activity
GR131_RS24975	COG0745	RESPONSE REGULATOR receiver
GR131_RS24980	COG2205	protein histidine kinase activity
GR131_RS25005	COG0756	dUTP diphosphatase activity
GR131_RS25025	COG4591	ABC-type transport system involved in lipoprotein release permease component
GR131_RS25025	COG1136	(ABC) transporter
GR131_RS25055	COG0569	domain protein
GR131_RS25060	COG0531	amino acid
GR131_RS25065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GR131_RS25095	COG2175	clavaminate synthase activity
GR131_RS25105	COG3251	PFAM MbtH domain protein
GR131_RS25115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GR131_RS25125	COG2197	response regulator
GR131_RS25135	COG1136	(ABC) transporter
GR131_RS25145	COG2197	response regulator
GR131_RS25150	COG0438	transferase activity, transferring glycosyl groups
GR131_RS25170	COG1063	alcohol dehydrogenase
GR131_RS25175	COG0395	ABC-type sugar transport system, permease component
GR131_RS25210	COG0559	Belongs to the binding-protein-dependent transport system permease family
GR131_RS25225	COG0402	S-adenosylhomocysteine deaminase activity
GR131_RS25230	COG2233	PERMEase
GR131_RS25305	COG1127	ABC transporter
GR131_RS25315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GR131_RS25340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GR131_RS25375	COG0656	L-ascorbic acid biosynthetic process
GR131_RS25390	COG0473	3-isopropylmalate dehydrogenase activity
GR131_RS25400	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GR131_RS25430	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS25445	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS25465	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS25475	COG0252	asparaginase activity
GR131_RS25480	COG1846	Transcriptional regulator
GR131_RS25480	COG1940	carbohydrate kinase activity
GR131_RS25485	COG1129	ABC transporter
GR131_RS25490	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR131_RS25495	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR131_RS25500	COG4213	ABC transporter substrate-binding protein
GR131_RS25515	COG0738	Major facilitator superfamily
GR131_RS25520	COG3226	Transcriptional regulator
GR131_RS25525	COG0438	transferase activity, transferring glycosyl groups
GR131_RS25575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GR131_RS25595	COG0640	Transcriptional regulator
GR131_RS25600	COG0789	Transcriptional regulator
GR131_RS25615	COG2050	protein possibly involved in aromatic compounds catabolism
GR131_RS25625	COG3540	Alkaline phosphatase
GR131_RS25645	COG2936	dipeptidyl-peptidase activity
GR131_RS25660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GR131_RS25675	COG1309	transcriptional regulator
GR131_RS25685	COG0747	negative chemotaxis
GR131_RS25695	COG0601	transmembrane transport
GR131_RS25700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR131_RS25720	COG1733	regulation of RNA biosynthetic process
GR131_RS25730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS25735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS25740	COG1120	ATPase activity
GR131_RS25755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GR131_RS25765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GR131_RS25805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GR131_RS25815	COG1620	l-lactate permease
GR131_RS25820	COG0247	lactate metabolic process
GR131_RS25825	COG1139	Iron-sulfur cluster binding protein
GR131_RS25830	COG1556	Lactate utilization protein
GR131_RS25845	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GR131_RS25855	COG1799	cell septum assembly
GR131_RS25885	COG2890	protein-(glutamine-N5) methyltransferase activity
GR131_RS25890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GR131_RS25905	COG2235	arginine
GR131_RS25910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GR131_RS25915	COG0531	amino acid
GR131_RS25945	COG2124	cytochrome p450
GR131_RS25955	COG2111	Na H antiporter
GR131_RS25955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GR131_RS25980	COG1320	monovalent cation:proton antiporter activity
GR131_RS25985	COG2235	arginine
GR131_RS26035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GR131_RS26060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GR131_RS26070	COG1175	transmembrane transport
GR131_RS26075	COG0395	ABC-type sugar transport system, permease component
GR131_RS26085	COG4213	ABC transporter substrate-binding protein
GR131_RS26095	COG4214	carbohydrate transport
GR131_RS26100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GR131_RS26105	COG0531	amino acid
GR131_RS26125	COG1024	Enoyl-CoA hydratase
GR131_RS26125	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS26130	COG0183	Belongs to the thiolase family
GR131_RS26150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GR131_RS26155	COG0446	pyridine nucleotide-disulphide oxidoreductase
GR131_RS26180	COG3220	belongs to the UPF0276 family
GR131_RS26190	COG0726	polysaccharide deacetylase
GR131_RS26200	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS26215	COG1595	DNA-templated transcription, initiation
GR131_RS26220	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GR131_RS26240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GR131_RS26245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GR131_RS26310	COG2176	DNA-directed DNA polymerase activity
GR131_RS26310	COG5002	protein histidine kinase activity
GR131_RS26345	COG0386	Belongs to the glutathione peroxidase family
GR131_RS26360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GR131_RS26365	COG1116	anion transmembrane transporter activity
GR131_RS26390	COG0529	Catalyzes the synthesis of activated sulfate
GR131_RS26395	COG0175	sulfate reduction
GR131_RS26405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR131_RS26435	COG1960	acyl-CoA dehydrogenase activity
GR131_RS26455	COG2040	homocysteine
GR131_RS26480	COG2255	four-way junction helicase activity
GR131_RS26490	COG1120	ATPase activity
GR131_RS26495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS26505	COG2409	Drug exporters of the RND superfamily
GR131_RS26510	COG1846	Transcriptional regulator
GR131_RS26515	COG0702	epimerase
GR131_RS26525	COG0789	Transcriptional regulator
GR131_RS26535	COG1595	DNA-templated transcription, initiation
GR131_RS26575	COG2365	Tyrosine phosphatase family
GR131_RS26585	COG1162	GTPase activity
GR131_RS26590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GR131_RS26610	COG0028	Belongs to the TPP enzyme family
GR131_RS26625	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS26640	COG1802	Transcriptional regulator
GR131_RS26650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GR131_RS26655	COG3835	regulator
GR131_RS26670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR131_RS26675	COG2252	PERMEase
GR131_RS26715	COG1309	transcriptional regulator
GR131_RS26725	COG2197	response regulator
GR131_RS26730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GR131_RS26735	COG0318	PFAM AMP-dependent synthetase and ligase
GR131_RS26745	COG3960	tartronate-semialdehyde synthase activity
GR131_RS26750	COG0753	catalase activity
GR131_RS26755	COG2084	Dehydrogenase
GR131_RS26760	COG3622	Belongs to the hyi family
GR131_RS26780	COG2351	hydroxyisourate hydrolase activity
GR131_RS26795	COG2233	PERMEase
GR131_RS26870	COG1621	beta-fructofuranosidase activity
GR131_RS26875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GR131_RS26880	COG3795	YCII-related domain
GR131_RS26885	COG4941	Belongs to the sigma-70 factor family
GR131_RS26890	COG0739	heme binding
GR131_RS26905	COG2080	2 iron, 2 sulfur cluster binding
GR131_RS26910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GR131_RS26915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR131_RS26930	COG1414	Transcriptional regulator
GR131_RS26935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR131_RS26950	COG4585	Histidine kinase
GR131_RS26955	COG2197	response regulator
GR131_RS26970	COG0673	inositol 2-dehydrogenase activity
GR131_RS26975	COG2188	Transcriptional regulator
GR131_RS26985	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR131_RS26995	COG1940	carbohydrate kinase activity
GR131_RS27005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GR131_RS27085	COG0464	growth
GR131_RS27095	COG2197	response regulator
GR131_RS27125	COG2207	Transcriptional regulator
GR131_RS27130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GR131_RS27135	COG2375	cellular response to nickel ion
GR131_RS27140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS27145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS27150	COG1120	ATPase activity
GR131_RS27155	COG1132	(ABC) transporter
GR131_RS27160	COG1132	(ABC) transporter
GR131_RS27195	COG1960	acyl-CoA dehydrogenase activity
GR131_RS27215	COG2267	carboxylic ester hydrolase activity
GR131_RS27225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR131_RS27230	COG1228	amidohydrolase
GR131_RS27260	COG1126	abc transporter atp-binding protein
GR131_RS27265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR131_RS27270	COG0765	amino acid transport
GR131_RS27275	COG0765	amino acid transport
GR131_RS27295	COG0739	heme binding
GR131_RS27295	COG1196	nuclear chromosome segregation
GR131_RS27295	COG0741	lytic transglycosylase activity
GR131_RS27330	COG2197	response regulator
GR131_RS27380	COG1309	transcriptional regulator
GR131_RS27395	COG0583	DNA-binding transcription factor activity
GR131_RS27425	COG3547	Transposase (IS116 IS110 IS902 family)
GR131_RS27435	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS27480	COG4566	intracellular signal transduction
GR131_RS27600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GR131_RS27605	COG0477	Major facilitator Superfamily
GR131_RS27610	COG2376	Dihydroxyacetone kinase
GR131_RS27615	COG2376	Dihydroxyacetone kinase
GR131_RS27620	COG0181	hydroxymethylbilane synthase activity
GR131_RS27675	COG1309	transcriptional regulator
GR131_RS27680	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS27760	COG0305	Participates in initiation and elongation during chromosome replication
GR131_RS27850	COG0714	Associated with various cellular activities
GR131_RS27910	COG0791	NLP P60 protein
GR131_RS27910	COG3883	PFAM NLP P60 protein
GR131_RS27960	COG1181	Belongs to the D-alanine--D-alanine ligase family
GR131_RS27980	COG1793	dna ligase
GR131_RS28085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GR131_RS28105	COG2226	methyltransferase
GR131_RS28120	COG2192	nodulation
GR131_RS28125	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GR131_RS28145	COG1324	tolerance protein
GR131_RS28175	COG1960	acyl-CoA dehydrogenase activity
GR131_RS28205	COG3387	PFAM Glycoside hydrolase 15-related
GR131_RS28255	COG0405	Gamma-glutamyltransferase
GR131_RS28275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR131_RS28280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR131_RS28300	COG0095	Lipoate-protein ligase
GR131_RS28310	COG0483	inositol monophosphate 1-phosphatase activity
GR131_RS28325	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GR131_RS28340	COG0159	tryptophan synthase activity
GR131_RS28365	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GR131_RS28375	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS28380	COG0702	epimerase
GR131_RS28385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GR131_RS28400	COG0488	(ABC) transporter
GR131_RS28405	COG1929	Belongs to the glycerate kinase type-1 family
GR131_RS28415	COG0688	phosphatidylethanolamine metabolic process
GR131_RS28430	COG2301	Belongs to the HpcH HpaI aldolase family
GR131_RS28450	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS28455	COG1120	ATPase activity
GR131_RS28460	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS28465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR131_RS28485	COG0596	Alpha beta hydrolase
GR131_RS28510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR131_RS28520	COG1619	proteins homologs of microcin C7 resistance protein MccF
GR131_RS28540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR131_RS28555	COG0604	alcohol dehydrogenase
GR131_RS28565	COG3226	Transcriptional regulator
GR131_RS28575	COG0739	heme binding
GR131_RS28580	COG4106	trans-aconitate 2-methyltransferase activity
GR131_RS28595	COG0693	protein deglycase activity
GR131_RS28655	COG1140	nitrate reductase beta subunit
GR131_RS28685	COG2154	pterin-4-alpha-carbinolamine dehydratase
GR131_RS28710	COG0583	DNA-binding transcription factor activity
GR131_RS28720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GR131_RS28730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR131_RS28735	COG1940	carbohydrate kinase activity
GR131_RS28740	COG1129	ABC transporter
GR131_RS28745	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR131_RS28750	COG1879	ABC-type sugar transport system periplasmic component
GR131_RS28755	COG0673	inositol 2-dehydrogenase activity
GR131_RS28820	COG1295	ribonuclease BN
GR131_RS28840	COG1609	Transcriptional regulator
GR131_RS28845	COG1129	ABC transporter
GR131_RS28850	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR131_RS28855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GR131_RS28860	COG1869	D-ribose catabolic process
GR131_RS28870	COG2259	Doxx family
GR131_RS28875	COG2814	Major facilitator Superfamily
GR131_RS28895	COG1012	belongs to the aldehyde dehydrogenase family
GR131_RS28955	COG1846	Transcriptional regulator
GR131_RS29000	COG0789	Transcriptional regulator
GR131_RS29035	COG1024	Enoyl-CoA hydratase
GR131_RS29040	COG1793	dna ligase
GR131_RS29050	COG0254	rRNA binding
GR131_RS29085	COG0438	transferase activity, transferring glycosyl groups
GR131_RS29105	COG0488	(ABC) transporter
GR131_RS29115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GR131_RS29115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GR131_RS29125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GR131_RS29155	COG1515	deoxyribonuclease V activity
GR131_RS29160	COG1683	Conserved Protein
GR131_RS29165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR131_RS29175	COG0183	Belongs to the thiolase family
GR131_RS29180	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS29180	COG1024	Enoyl-CoA hydratase
GR131_RS29185	COG0789	Transcriptional regulator
GR131_RS29190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GR131_RS29215	COG0402	S-adenosylhomocysteine deaminase activity
GR131_RS29220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR131_RS29225	COG1802	Transcriptional regulator
GR131_RS29240	COG2183	response to ionizing radiation
GR131_RS29255	COG1024	Enoyl-CoA hydratase
GR131_RS29270	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GR131_RS29285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GR131_RS29310	COG1388	LysM domain
GR131_RS29310	COG1134	teichoic acid transport
GR131_RS29315	COG1562	ergosterol biosynthetic process
GR131_RS29325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GR131_RS29335	COG1657	PFAM Prenyltransferase squalene oxidase
GR131_RS29370	COG2755	lipolytic protein G-D-S-L family
GR131_RS29440	COG3958	Transketolase
GR131_RS29445	COG3959	Transketolase, thiamine diphosphate binding domain
GR131_RS29465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GR131_RS29470	COG4521	taurine ABC transporter
GR131_RS29475	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GR131_RS29505	COG0740	serine-type endopeptidase activity
GR131_RS29510	COG0740	serine-type endopeptidase activity
GR131_RS29555	COG2391	methyltransferase activity
GR131_RS29560	COG1960	acyl-CoA dehydrogenase activity
GR131_RS29565	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS29570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GR131_RS29575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GR131_RS29580	COG0583	DNA-binding transcription factor activity
GR131_RS29590	COG0477	Major facilitator Superfamily
GR131_RS29665	COG1233	COG1233 Phytoene dehydrogenase and related
GR131_RS29670	COG2130	NADP-dependent
GR131_RS29675	COG2124	cytochrome p450
GR131_RS29685	COG1070	Carbohydrate kinase
GR131_RS29710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GR131_RS29755	COG2018	Roadblock/LC7 domain
GR131_RS29770	COG1946	Acyl-CoA thioesterase
GR131_RS29785	COG1132	(ABC) transporter
GR131_RS29790	COG1132	(ABC) transporter
GR131_RS29810	COG1132	(ABC) transporter
GR131_RS29815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GR131_RS29825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS29835	COG1116	anion transmembrane transporter activity
GR131_RS29840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GR131_RS29845	COG0432	Pfam Uncharacterised protein family UPF0047
GR131_RS29850	COG1609	Transcriptional regulator
GR131_RS29860	COG1175	transmembrane transport
GR131_RS29880	COG1309	transcriptional regulator
GR131_RS29885	COG0477	Major facilitator Superfamily
GR131_RS29905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GR131_RS29925	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GR131_RS29965	COG2814	Major facilitator Superfamily
GR131_RS29970	COG2207	Transcriptional regulator
GR131_RS29975	COG1120	ATPase activity
GR131_RS29980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GR131_RS30000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GR131_RS30025	COG0583	DNA-binding transcription factor activity
GR131_RS30030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GR131_RS30045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GR131_RS30065	COG0243	molybdopterin cofactor binding
GR131_RS30070	COG0076	glutamate decarboxylase activity
GR131_RS30075	COG0071	Belongs to the small heat shock protein (HSP20) family
GR131_RS30090	COG2706	6-phosphogluconolactonase activity
GR131_RS30105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GR131_RS30120	COG1902	pentaerythritol trinitrate reductase activity
GR131_RS30125	COG0640	Transcriptional regulator
GR131_RS30130	COG2233	PERMEase
GR131_RS30160	COG0671	phosphoesterase, PA-phosphatase related
GR131_RS30180	COG1846	Transcriptional regulator
GR131_RS30195	COG0584	glycerophosphoryl diester phosphodiesterase
GR131_RS30235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GR131_RS30245	COG1609	Transcriptional regulator
GR131_RS30260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GR131_RS30265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR131_RS30275	COG2197	response regulator
GR131_RS30290	COG2223	nitrite transmembrane transporter activity
GR131_RS30300	COG1940	carbohydrate kinase activity
GR131_RS30320	COG1349	DNA-binding transcription factor activity
GR131_RS30340	COG0633	Ferredoxin
GR131_RS30340	COG3217	Mosc domain protein beta barrel domain protein
GR131_RS30355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GR131_RS30365	COG0513	Belongs to the DEAD box helicase family
GR131_RS30380	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS30405	COG1695	Transcriptional regulator
GR131_RS30460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GR131_RS30465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GR131_RS30465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GR131_RS30470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GR131_RS30470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GR131_RS30470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GR131_RS30480	COG1349	DNA-binding transcription factor activity
GR131_RS30495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR131_RS30505	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR131_RS30515	COG1960	acyl-CoA dehydrogenase activity
GR131_RS30525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR131_RS30545	COG1120	ATPase activity
GR131_RS30560	COG0640	Transcriptional regulator
GR131_RS30565	COG0346	lactoylglutathione lyase activity
GR131_RS30575	COG0702	epimerase
GR131_RS30615	COG1131	(ABC) transporter
GR131_RS30620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GR131_RS30625	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS30655	COG0667	Aldo Keto reductase
GR131_RS30680	COG0149	triose-phosphate isomerase activity
GR131_RS30700	COG1595	DNA-templated transcription, initiation
GR131_RS30730	COG0431	NADPH-dependent FMN reductase
GR131_RS30735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR131_RS30740	COG0328	RNA-DNA hybrid ribonuclease activity
GR131_RS30755	COG0477	Major facilitator Superfamily
GR131_RS30780	COG3268	Saccharopine dehydrogenase
GR131_RS30790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GR131_RS30805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR131_RS30820	COG2197	response regulator
GR131_RS30840	COG0475	glutathione-regulated potassium exporter activity
GR131_RS30875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GR131_RS30885	COG0446	pyridine nucleotide-disulphide oxidoreductase
GR131_RS30885	COG1902	pentaerythritol trinitrate reductase activity
GR131_RS30905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS30915	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GR131_RS30925	COG0713	ATP synthesis coupled electron transport
GR131_RS30930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GR131_RS30935	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR131_RS30940	COG1007	ATP synthesis coupled electron transport
GR131_RS30960	COG2267	carboxylic ester hydrolase activity
GR131_RS30975	COG2084	Dehydrogenase
GR131_RS31005	COG2356	endonuclease I
GR131_RS31015	COG2813	Specifically methylates the guanine in position
GR131_RS31025	COG0589	response to stress
GR131_RS31030	COG0318	PFAM AMP-dependent synthetase and ligase
GR131_RS31085	COG0277	FAD linked oxidase domain protein
GR131_RS31120	COG1793	dna ligase
GR131_RS31145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GR131_RS31160	COG0601	transmembrane transport
GR131_RS31165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR131_RS31170	COG0444	Belongs to the ABC transporter superfamily
GR131_RS31175	COG4608	Belongs to the ABC transporter superfamily
GR131_RS31225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GR131_RS31225	COG0446	pyridine nucleotide-disulphide oxidoreductase
GR131_RS31300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GR131_RS31305	COG4585	Histidine kinase
GR131_RS31310	COG2197	response regulator
GR131_RS31320	COG2080	2 iron, 2 sulfur cluster binding
GR131_RS31325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GR131_RS31330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR131_RS31355	COG0477	Major facilitator Superfamily
GR131_RS31360	COG1028	Short-chain dehydrogenase reductase Sdr
GR131_RS31380	COG1175	transmembrane transport
GR131_RS31385	COG0395	ABC-type sugar transport system, permease component
GR131_RS31390	COG1609	Transcriptional regulator
GR131_RS31395	COG1874	Beta-galactosidase
GR131_RS31440	COG0494	nUDIX hydrolase