locus-tag	class	description
GR130_RS00010	COG0592	DNA-directed DNA polymerase activity
GR130_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GR130_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GR130_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GR130_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GR130_RS00060	COG0515	serine threonine protein kinase
GR130_RS00080	COG0583	DNA-binding transcription factor activity
GR130_RS00095	COG0705	Rhomboid family
GR130_RS00110	COG3764	Sortase (surface protein transpeptidase)
GR130_RS00120	COG3764	Sortase (surface protein transpeptidase)
GR130_RS00125	COG3764	Sortase (surface protein transpeptidase)
GR130_RS00130	COG0515	serine threonine protein kinase
GR130_RS00135	COG0768	penicillin binding
GR130_RS00150	COG1716	ATPase activity
GR130_RS00155	COG1716	ATPase activity
GR130_RS00165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GR130_RS00170	COG1733	regulation of RNA biosynthetic process
GR130_RS00205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GR130_RS00210	COG2151	metal-sulfur cluster biosynthetic enzyme
GR130_RS00215	COG3396	Phenylacetate-CoA oxygenase
GR130_RS00220	COG3460	Phenylacetate-CoA oxygenase
GR130_RS00225	COG3396	Phenylacetate-CoA oxygenase
GR130_RS00250	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR130_RS00255	COG1309	transcriptional regulator
GR130_RS00260	COG1522	sequence-specific DNA binding
GR130_RS00310	COG4106	trans-aconitate 2-methyltransferase activity
GR130_RS00325	COG2391	methyltransferase activity
GR130_RS00355	COG0515	serine threonine protein kinase
GR130_RS00360	COG0515	serine threonine protein kinase
GR130_RS00385	COG0022	dehydrogenase e1 component
GR130_RS00390	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR130_RS00395	COG0456	acetyltransferase
GR130_RS00445	COG3903	Transcriptional regulator
GR130_RS00445	COG3629	intracellular signal transduction
GR130_RS00450	COG1362	aminopeptidase activity
GR130_RS00455	COG1960	acyl-CoA dehydrogenase activity
GR130_RS00480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GR130_RS00485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR130_RS00510	COG1174	glycine betaine transport
GR130_RS00550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GR130_RS00570	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GR130_RS00615	COG1316	TRANSCRIPTIONal
GR130_RS00665	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS00670	COG2030	dehydratase
GR130_RS00680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS00725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS00735	COG0515	serine threonine protein kinase
GR130_RS00745	COG2197	response regulator
GR130_RS00750	COG4585	Histidine kinase
GR130_RS00750	COG2203	Gaf domain
GR130_RS00760	COG1652	LysM domain
GR130_RS00795	COG2301	Belongs to the HpcH HpaI aldolase family
GR130_RS00810	COG2197	response regulator
GR130_RS00815	COG4585	Histidine kinase
GR130_RS00835	COG2378	regulation of single-species biofilm formation
GR130_RS00840	COG4585	Histidine kinase
GR130_RS00845	COG2197	response regulator
GR130_RS00855	COG0829	nickel cation binding
GR130_RS00860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GR130_RS00870	COG0804	urea catabolic process
GR130_RS00875	COG0831	urea catabolic process
GR130_RS00875	COG0832	Belongs to the urease beta subunit family
GR130_RS00880	COG1335	isochorismatase
GR130_RS00895	COG1595	DNA-templated transcription, initiation
GR130_RS00920	COG0531	amino acid
GR130_RS00935	COG0432	Pfam Uncharacterised protein family UPF0047
GR130_RS00975	COG0105	UTP biosynthetic process
GR130_RS01050	COG0717	Belongs to the dCTP deaminase family
GR130_RS01070	COG2801	Transposase and inactivated derivatives
GR130_RS01070	COG3415	Transposase
GR130_RS01080	COG2181	nitrate reductase activity
GR130_RS01080	COG0247	lactate metabolic process
GR130_RS01085	COG0443	Heat shock 70 kDa protein
GR130_RS01090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GR130_RS01095	COG0484	heat shock protein binding
GR130_RS01100	COG0789	Transcriptional regulator
GR130_RS01120	COG0542	response to heat
GR130_RS01150	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GR130_RS01165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GR130_RS01170	COG0191	fructose-bisphosphate aldolase activity
GR130_RS01185	COG3483	tryptophan 2,3-dioxygenase activity
GR130_RS01190	COG3844	kynureninase activity
GR130_RS01200	COG4585	Histidine kinase
GR130_RS01205	COG2197	response regulator
GR130_RS01210	COG3559	Exporter of polyketide antibiotics
GR130_RS01215	COG1131	(ABC) transporter
GR130_RS01230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GR130_RS01235	COG0515	serine threonine protein kinase
GR130_RS01235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GR130_RS01250	COG1802	Transcriptional regulator
GR130_RS01265	COG0151	Belongs to the GarS family
GR130_RS01280	COG0583	DNA-binding transcription factor activity
GR130_RS01290	COG2814	Major facilitator Superfamily
GR130_RS01295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GR130_RS01320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GR130_RS01325	COG0047	phosphoribosylformylglycinamidine synthase activity
GR130_RS01330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GR130_RS01345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GR130_RS01350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GR130_RS01385	COG1643	Atp-dependent helicase
GR130_RS01425	COG0513	Belongs to the DEAD box helicase family
GR130_RS01450	COG0667	Aldo Keto reductase
GR130_RS01460	COG0667	Aldo Keto reductase
GR130_RS01465	COG0789	Transcriptional regulator
GR130_RS01475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GR130_RS01480	COG0579	oxidoreductase
GR130_RS01545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GR130_RS01555	COG0123	including yeast histone deacetylase and acetoin utilization protein
GR130_RS01595	COG0560	Phosphoserine phosphatase
GR130_RS01605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GR130_RS01610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GR130_RS01615	COG0181	hydroxymethylbilane synthase activity
GR130_RS01620	COG1648	precorrin-2 dehydrogenase activity
GR130_RS01620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GR130_RS01625	COG0113	porphobilinogen synthase activity
GR130_RS01640	COG0018	arginyl-trna synthetase
GR130_RS01645	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GR130_RS01665	COG1690	Belongs to the RtcB family
GR130_RS01675	COG1742	UPF0060 membrane protein
GR130_RS01680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS01710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GR130_RS01715	COG0406	alpha-ribazole phosphatase activity
GR130_RS01730	COG0785	Cytochrome C biogenesis protein
GR130_RS01735	COG1333	cytochrome c biogenesis protein
GR130_RS01765	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GR130_RS01770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GR130_RS01785	COG0163	prenyltransferase activity
GR130_RS01795	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GR130_RS01810	COG1301	dicarboxylic acid transport
GR130_RS01815	COG3226	Transcriptional regulator
GR130_RS01875	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GR130_RS01880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GR130_RS01890	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GR130_RS01900	COG2226	methyltransferase
GR130_RS01940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR130_RS01945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR130_RS01950	COG0649	NAD binding
GR130_RS01960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GR130_RS01965	COG1034	ATP synthesis coupled electron transport
GR130_RS01970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GR130_RS01975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR130_RS01980	COG0839	Belongs to the complex I subunit 6 family
GR130_RS01985	COG0713	ATP synthesis coupled electron transport
GR130_RS01990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GR130_RS02000	COG1007	ATP synthesis coupled electron transport
GR130_RS02025	COG0142	geranyltranstransferase activity
GR130_RS02050	COG1013	pyruvate-flavodoxin oxidoreductase activity
GR130_RS02055	COG0674	pyruvate-flavodoxin oxidoreductase activity
GR130_RS02055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GR130_RS02065	COG4585	Histidine kinase
GR130_RS02070	COG4585	Histidine kinase
GR130_RS02085	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR130_RS02090	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR130_RS02095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR130_RS02100	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GR130_RS02105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GR130_RS02115	COG0713	ATP synthesis coupled electron transport
GR130_RS02120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GR130_RS02130	COG1007	ATP synthesis coupled electron transport
GR130_RS02135	COG0501	Belongs to the peptidase M48B family
GR130_RS02140	COG3304	Inner membrane component domain
GR130_RS02170	COG1666	GTP binding
GR130_RS02190	COG0702	epimerase
GR130_RS02210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GR130_RS02215	COG2030	dehydratase
GR130_RS02225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GR130_RS02230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR130_RS02235	COG0436	Aminotransferase
GR130_RS02250	COG0250	Participates in transcription elongation, termination and antitermination
GR130_RS02255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GR130_RS02260	COG0081	regulation of translation
GR130_RS02270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GR130_RS02275	COG0222	ribosome binding
GR130_RS02280	COG0085	RNA polymerase activity
GR130_RS02285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GR130_RS02295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GR130_RS02300	COG0049	tRNA binding
GR130_RS02305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GR130_RS02330	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS02330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS02330	COG3321	synthase
GR130_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS02330	COG0300	oxidoreductase activity
GR130_RS02335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS02335	COG3321	synthase
GR130_RS02335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GR130_RS02335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS02335	COG3321	synthase
GR130_RS02335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GR130_RS02335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS02335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS02340	COG0300	oxidoreductase activity
GR130_RS02340	COG3321	synthase
GR130_RS02340	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS02340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS02345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS02345	COG3321	synthase
GR130_RS02345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GR130_RS02345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS02375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GR130_RS02385	COG0154	amidase activity
GR130_RS02410	COG0667	Aldo Keto reductase
GR130_RS02425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GR130_RS02425	COG2070	2-Nitropropane dioxygenase
GR130_RS02430	COG2226	methyltransferase
GR130_RS02435	COG1819	glycosyl
GR130_RS02445	COG0051	transcription antitermination factor activity, RNA binding
GR130_RS02450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GR130_RS02455	COG0088	Forms part of the polypeptide exit tunnel
GR130_RS02460	COG0089	rRNA binding
GR130_RS02465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GR130_RS02470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GR130_RS02475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GR130_RS02480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GR130_RS02485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GR130_RS02490	COG0255	Belongs to the universal ribosomal protein uL29 family
GR130_RS02495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GR130_RS02500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GR130_RS02505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GR130_RS02510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GR130_RS02515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GR130_RS02525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GR130_RS02530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GR130_RS02535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GR130_RS02540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GR130_RS02545	COG1841	ribosomal large subunit assembly
GR130_RS02550	COG0200	Binds to the 23S rRNA
GR130_RS02560	COG0563	adenylate kinase activity
GR130_RS02570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GR130_RS02575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GR130_RS02580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GR130_RS02585	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GR130_RS02590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GR130_RS02595	COG0202	RNA polymerase activity
GR130_RS02600	COG0203	ribosomal protein L17
GR130_RS02605	COG0101	tRNA pseudouridine synthase activity
GR130_RS02615	COG0488	(ABC) transporter
GR130_RS02625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GR130_RS02630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GR130_RS02635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GR130_RS02640	COG1072	(Pantothenic acid kinase))
GR130_RS02655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GR130_RS02660	COG0736	holo-[acyl-carrier-protein] synthase activity
GR130_RS02665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GR130_RS02665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GR130_RS02670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GR130_RS02680	COG0802	atpase or kinase
GR130_RS02705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GR130_RS02720	COG0772	Belongs to the SEDS family
GR130_RS02735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GR130_RS02750	COG0583	DNA-binding transcription factor activity
GR130_RS02765	COG1595	DNA-templated transcription, initiation
GR130_RS02775	COG0516	GMP reductase activity
GR130_RS02785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GR130_RS02805	COG1960	acyl-CoA dehydrogenase activity
GR130_RS02810	COG1960	acyl-CoA dehydrogenase activity
GR130_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS02830	COG1960	acyl-CoA dehydrogenase activity
GR130_RS02840	COG2271	Major facilitator Superfamily
GR130_RS02850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GR130_RS02865	COG1024	Enoyl-CoA hydratase
GR130_RS02870	COG0045	succinate-CoA ligase (ADP-forming) activity
GR130_RS02870	COG1042	CoA-binding domain protein
GR130_RS02870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR130_RS02885	COG0259	pyridoxamine-phosphate oxidase activity
GR130_RS02900	COG1960	acyl-CoA dehydrogenase activity
GR130_RS02910	COG1309	transcriptional regulator
GR130_RS02915	COG0515	serine threonine protein kinase
GR130_RS02915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GR130_RS02930	COG1024	Enoyl-CoA hydratase
GR130_RS03025	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GR130_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS03060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS03080	COG1686	Belongs to the peptidase S11 family
GR130_RS03090	COG0640	Transcriptional regulator
GR130_RS03105	COG2205	protein histidine kinase activity
GR130_RS03110	COG0514	ATP-dependent DNA helicase (RecQ)
GR130_RS03215	COG2186	Transcriptional regulator
GR130_RS03295	COG1309	transcriptional regulator
GR130_RS03320	COG3384	dioxygenase
GR130_RS03335	COG1247	-acetyltransferase
GR130_RS03345	COG1349	DNA-binding transcription factor activity
GR130_RS03350	COG1105	Belongs to the carbohydrate kinase PfkB family
GR130_RS03420	COG2188	Transcriptional regulator
GR130_RS03425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GR130_RS03435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GR130_RS03450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GR130_RS03465	COG3263	regulation of cellular component size
GR130_RS03475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GR130_RS03480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GR130_RS03490	COG0315	cyclic pyranopterin monophosphate synthase activity
GR130_RS03495	COG0315	cyclic pyranopterin monophosphate synthase activity
GR130_RS03495	COG0521	Mo-molybdopterin cofactor biosynthetic process
GR130_RS03530	COG0789	Transcriptional regulator
GR130_RS03540	COG2205	protein histidine kinase activity
GR130_RS03545	COG1725	Transcriptional regulator
GR130_RS03555	COG1131	(ABC) transporter
GR130_RS03580	COG2072	flavoprotein involved in K transport
GR130_RS03585	COG2267	carboxylic ester hydrolase activity
GR130_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS03600	COG4946	Tricorn protease homolog
GR130_RS03600	COG0793	Belongs to the peptidase S41A family
GR130_RS03645	COG0084	hydrolase, TatD family'
GR130_RS03655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GR130_RS03660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GR130_RS03695	COG0488	(ABC) transporter
GR130_RS03725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GR130_RS03730	COG2197	response regulator
GR130_RS03745	COG1846	Transcriptional regulator
GR130_RS03750	COG4106	trans-aconitate 2-methyltransferase activity
GR130_RS03755	COG1309	transcriptional regulator
GR130_RS03765	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GR130_RS03775	COG0193	aminoacyl-tRNA hydrolase activity
GR130_RS03780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GR130_RS03785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GR130_RS03790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GR130_RS03800	COG4585	Histidine kinase
GR130_RS03830	COG2814	Major facilitator Superfamily
GR130_RS03865	COG0515	serine threonine protein kinase
GR130_RS03865	COG2815	serine threonine protein kinase
GR130_RS03915	COG2814	Major facilitator Superfamily
GR130_RS03925	COG2124	cytochrome p450
GR130_RS03930	COG1652	LysM domain
GR130_RS03940	COG0148	phosphopyruvate hydratase activity
GR130_RS03965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GR130_RS03970	COG0577	efflux transmembrane transporter activity
GR130_RS03975	COG0577	efflux transmembrane transporter activity
GR130_RS03975	COG1136	(ABC) transporter
GR130_RS03985	COG0297	glycogen (starch) synthase activity
GR130_RS03990	COG0463	Glycosyl transferase, family 2
GR130_RS03990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GR130_RS04015	COG0183	Belongs to the thiolase family
GR130_RS04035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GR130_RS04050	COG1609	Transcriptional regulator
GR130_RS04095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GR130_RS04110	COG1228	amidohydrolase
GR130_RS04115	COG1191	sigma factor activity
GR130_RS04120	COG1366	Belongs to the anti-sigma-factor antagonist family
GR130_RS04155	COG3104	oligopeptide transport
GR130_RS04160	COG0745	RESPONSE REGULATOR receiver
GR130_RS04165	COG2205	protein histidine kinase activity
GR130_RS04195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GR130_RS04250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GR130_RS04275	COG1316	TRANSCRIPTIONal
GR130_RS04295	COG1316	TRANSCRIPTIONal
GR130_RS04335	COG0778	Nitroreductase
GR130_RS04335	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GR130_RS04375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GR130_RS04390	COG1482	cell wall glycoprotein biosynthetic process
GR130_RS04400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GR130_RS04400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GR130_RS04400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GR130_RS04405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GR130_RS04445	COG0714	Associated with various cellular activities
GR130_RS04465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GR130_RS04470	COG0745	RESPONSE REGULATOR receiver
GR130_RS04480	COG0823	Involved in the tonB-independent uptake of proteins
GR130_RS04490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GR130_RS04495	COG2197	response regulator
GR130_RS04500	COG3214	Protein conserved in bacteria
GR130_RS04510	COG0653	protein targeting
GR130_RS04525	COG0546	phosphoglycolate phosphatase activity
GR130_RS04530	COG2902	Dehydrogenase
GR130_RS04535	COG1134	teichoic acid transport
GR130_RS04535	COG1388	LysM domain
GR130_RS04545	COG1309	transcriptional regulator
GR130_RS04550	COG0515	serine threonine protein kinase
GR130_RS04565	COG0463	Glycosyl transferase, family 2
GR130_RS04620	COG0395	ABC-type sugar transport system, permease component
GR130_RS04640	COG0515	serine threonine protein kinase
GR130_RS04645	COG0515	serine threonine protein kinase
GR130_RS04650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GR130_RS04665	COG2884	Cell division ATP-binding protein ftsE
GR130_RS04670	COG2177	Part of the ABC transporter FtsEX involved in
GR130_RS04675	COG0793	Belongs to the peptidase S41A family
GR130_RS04680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GR130_RS04700	COG2223	nitrite transmembrane transporter activity
GR130_RS04720	COG3973	AAA domain
GR130_RS04730	COG0776	regulation of translation
GR130_RS04740	COG2186	Transcriptional regulator
GR130_RS04755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GR130_RS04760	COG1678	Uncharacterized ACR, COG1678
GR130_RS04775	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GR130_RS04790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR130_RS04820	COG1174	glycine betaine transport
GR130_RS04825	COG1125	glycine betaine transport
GR130_RS04825	COG0517	IMP dehydrogenase activity
GR130_RS04830	COG1174	glycine betaine transport
GR130_RS04840	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GR130_RS04845	COG0277	FAD linked oxidase domain protein
GR130_RS04875	COG0222	ribosome binding
GR130_RS04880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GR130_RS04910	COG1335	isochorismatase
GR130_RS04920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GR130_RS04930	COG1113	amino acid transport
GR130_RS04955	COG1234	tRNA 3'-trailer cleavage
GR130_RS04960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GR130_RS04960	COG1263	PTS System
GR130_RS04965	COG1263	PTS System
GR130_RS04965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GR130_RS04970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GR130_RS04970	COG1263	PTS System
GR130_RS04975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GR130_RS04985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GR130_RS05010	COG2205	protein histidine kinase activity
GR130_RS05025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GR130_RS05035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GR130_RS05065	COG2733	membrane
GR130_RS05075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR130_RS05120	COG0706	membrane insertase activity
GR130_RS05150	COG4702	Belongs to the UPF0303 family
GR130_RS05155	COG0673	inositol 2-dehydrogenase activity
GR130_RS05165	COG2188	Transcriptional regulator
GR130_RS05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR130_RS05235	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS05250	COG1126	abc transporter atp-binding protein
GR130_RS05255	COG0765	amino acid transport
GR130_RS05260	COG0765	amino acid transport
GR130_RS05275	COG0154	amidase activity
GR130_RS05295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS05340	COG0588	phosphoglycerate mutase activity
GR130_RS05355	COG0438	transferase activity, transferring glycosyl groups
GR130_RS05360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GR130_RS05365	COG0438	transferase activity, transferring glycosyl groups
GR130_RS05400	COG3979	chitinase
GR130_RS05420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GR130_RS05425	COG4977	sequence-specific DNA binding
GR130_RS05435	COG0589	response to stress
GR130_RS05440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GR130_RS05460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GR130_RS05480	COG1960	acyl-CoA dehydrogenase activity
GR130_RS05495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR130_RS05500	COG1309	transcriptional regulator
GR130_RS05505	COG1960	acyl-CoA dehydrogenase activity
GR130_RS05510	COG1946	Acyl-CoA thioesterase
GR130_RS05560	COG1309	transcriptional regulator
GR130_RS05565	COG1511	domain protein
GR130_RS05565	COG0842	Transport permease protein
GR130_RS05570	COG1129	ABC transporter
GR130_RS05570	COG0842	Transport permease protein
GR130_RS05590	COG1472	Belongs to the glycosyl hydrolase 3 family
GR130_RS05605	COG0673	inositol 2-dehydrogenase activity
GR130_RS05620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GR130_RS05630	COG2608	mercury ion transmembrane transporter activity
GR130_RS05635	COG0586	Pfam SNARE associated Golgi protein
GR130_RS05650	COG0673	inositol 2-dehydrogenase activity
GR130_RS05655	COG1609	Transcriptional regulator
GR130_RS05665	COG2814	Major facilitator Superfamily
GR130_RS05670	COG0673	inositol 2-dehydrogenase activity
GR130_RS05680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GR130_RS05690	COG3718	enzyme involved in inositol metabolism
GR130_RS05695	COG3962	Belongs to the TPP enzyme family
GR130_RS05720	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GR130_RS05730	COG1077	Cell shape determining protein MreB Mrl
GR130_RS05785	COG0745	RESPONSE REGULATOR receiver
GR130_RS05795	COG2815	serine threonine protein kinase
GR130_RS05795	COG0515	serine threonine protein kinase
GR130_RS05870	COG0629	single-stranded DNA binding
GR130_RS05895	COG2346	COG2346, Truncated hemoglobins
GR130_RS05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR130_RS05935	COG2186	Transcriptional regulator
GR130_RS05950	COG1486	melibiose metabolic process
GR130_RS05955	COG0395	ABC-type sugar transport system, permease component
GR130_RS05960	COG1175	transmembrane transport
GR130_RS05970	COG1940	carbohydrate kinase activity
GR130_RS05970	COG1846	Transcriptional regulator
GR130_RS05980	COG0668	transmembrane transport
GR130_RS06025	COG4266	Belongs to the allantoicase family
GR130_RS06050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GR130_RS06055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GR130_RS06060	COG1113	amino acid transport
GR130_RS06065	COG1113	amino acid transport
GR130_RS06075	COG1113	amino acid transport
GR130_RS06080	COG0698	ribose 5-phosphate isomerase
GR130_RS06090	COG4552	Acetyltransferase involved in intracellular survival and related
GR130_RS06105	COG1136	(ABC) transporter
GR130_RS06130	COG0544	peptidyl-prolyl cis-trans isomerase activity
GR130_RS06135	COG0740	serine-type endopeptidase activity
GR130_RS06140	COG0740	serine-type endopeptidase activity
GR130_RS06145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GR130_RS06155	COG0525	valine-tRNA ligase activity
GR130_RS06165	COG0768	penicillin binding
GR130_RS06170	COG0285	dihydrofolate synthase activity
GR130_RS06180	COG0105	UTP biosynthetic process
GR130_RS06185	COG1077	Cell shape determining protein MreB Mrl
GR130_RS06200	COG0768	penicillin binding
GR130_RS06205	COG0772	Belongs to the SEDS family
GR130_RS06260	COG0640	Transcriptional regulator
GR130_RS06265	COG0798	PFAM Bile acid sodium symporter
GR130_RS06290	COG1530	ribonuclease E activity
GR130_RS06295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GR130_RS06300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GR130_RS06305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GR130_RS06315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GR130_RS06325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GR130_RS06340	COG0501	Belongs to the peptidase M48B family
GR130_RS06345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GR130_RS06355	COG0799	negative regulation of ribosome biogenesis
GR130_RS06360	COG0588	phosphoglycerate mutase activity
GR130_RS06405	COG0495	leucyl-tRNA aminoacylation
GR130_RS06415	COG1307	EDD domain protein, DegV family
GR130_RS06420	COG1555	photosystem II stabilization
GR130_RS06445	COG0268	Binds directly to 16S ribosomal RNA
GR130_RS06450	COG0481	GTPase activity
GR130_RS06455	COG1022	Amp-dependent synthetase and ligase
GR130_RS06465	COG2801	Transposase and inactivated derivatives
GR130_RS06465	COG3415	Transposase
GR130_RS06490	COG1420	regulation of RNA biosynthetic process
GR130_RS06495	COG0484	heat shock protein binding
GR130_RS06515	COG0537	adenosine 5'-monophosphoramidase activity
GR130_RS06520	COG1234	tRNA 3'-trailer cleavage
GR130_RS06530	COG4948	Mandelate Racemase Muconate Lactonizing
GR130_RS06565	COG0789	Transcriptional regulator
GR130_RS06575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GR130_RS06580	COG1486	melibiose metabolic process
GR130_RS06585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GR130_RS06595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GR130_RS06610	COG0667	Aldo Keto reductase
GR130_RS06615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GR130_RS06635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GR130_RS06650	COG2124	cytochrome p450
GR130_RS06690	COG1381	Involved in DNA repair and RecF pathway recombination
GR130_RS06695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GR130_RS06705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GR130_RS06710	COG1121	(ABC) transporter
GR130_RS06720	COG0423	glycine-tRNA ligase activity
GR130_RS06730	COG0667	Aldo Keto reductase
GR130_RS06735	COG0477	Major facilitator Superfamily
GR130_RS06765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GR130_RS06765	COG0574	Belongs to the PEP-utilizing enzyme family
GR130_RS06790	COG0535	radical SAM domain protein
GR130_RS06815	COG1175	transmembrane transport
GR130_RS06830	COG0531	amino acid
GR130_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS06845	COG0640	Transcriptional regulator
GR130_RS06860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR130_RS06860	COG2146	nitrite reductase [NAD(P)H] activity
GR130_RS06865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR130_RS06875	COG2197	response regulator
GR130_RS06885	COG1473	amidohydrolase
GR130_RS06910	COG0667	Aldo Keto reductase
GR130_RS06920	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GR130_RS06955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR130_RS06960	COG0243	molybdopterin cofactor binding
GR130_RS06970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GR130_RS06980	COG0358	DNA primase activity
GR130_RS06985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GR130_RS06990	COG1070	Carbohydrate kinase
GR130_RS07020	COG2226	methyltransferase
GR130_RS07035	COG1834	amidinotransferase
GR130_RS07090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GR130_RS07095	COG0588	phosphoglycerate mutase activity
GR130_RS07100	COG1077	Cell shape determining protein MreB Mrl
GR130_RS07140	COG0500	methyltransferase
GR130_RS07165	COG0477	Major facilitator Superfamily
GR130_RS07170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GR130_RS07180	COG2130	NADP-dependent
GR130_RS07185	COG1764	response to oxidative stress
GR130_RS07195	COG1129	ABC transporter
GR130_RS07205	COG1879	ABC-type sugar transport system periplasmic component
GR130_RS07210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GR130_RS07220	COG1309	transcriptional regulator
GR130_RS07250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS07255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS07260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR130_RS07265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GR130_RS07285	COG0789	Transcriptional regulator
GR130_RS07290	COG0667	Aldo Keto reductase
GR130_RS07305	COG2197	response regulator
GR130_RS07310	COG4585	Histidine kinase
GR130_RS07325	COG1309	transcriptional regulator
GR130_RS07330	COG0477	Major facilitator Superfamily
GR130_RS07340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GR130_RS07385	COG1358	cellular component organization or biogenesis
GR130_RS07410	COG4948	Mandelate Racemase Muconate Lactonizing
GR130_RS07415	COG2186	Transcriptional regulator
GR130_RS07495	COG0583	DNA-binding transcription factor activity
GR130_RS07530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS07545	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GR130_RS07570	COG1072	(Pantothenic acid kinase))
GR130_RS07655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GR130_RS07665	COG2124	cytochrome p450
GR130_RS07670	COG0183	Belongs to the thiolase family
GR130_RS07680	COG3845	ABC transporter
GR130_RS07715	COG1309	transcriptional regulator
GR130_RS07720	COG0438	transferase activity, transferring glycosyl groups
GR130_RS07745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS07755	COG0860	N-Acetylmuramoyl-L-alanine amidase
GR130_RS07765	COG1960	acyl-CoA dehydrogenase activity
GR130_RS07770	COG0183	Belongs to the thiolase family
GR130_RS07780	COG2197	response regulator
GR130_RS07785	COG4585	Histidine kinase
GR130_RS07795	COG1131	(ABC) transporter
GR130_RS07810	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS07820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GR130_RS07825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GR130_RS07835	COG0328	RNA-DNA hybrid ribonuclease activity
GR130_RS07835	COG0406	alpha-ribazole phosphatase activity
GR130_RS07840	COG0800	Aldolase
GR130_RS07845	COG3022	response to hydroperoxide
GR130_RS07850	COG0557	exoribonuclease II activity
GR130_RS07860	COG0789	Transcriptional regulator
GR130_RS07870	COG2197	response regulator
GR130_RS07875	COG4585	Histidine kinase
GR130_RS07880	COG3963	phosphatidate phosphatase activity
GR130_RS07890	COG0577	efflux transmembrane transporter activity
GR130_RS07890	COG1136	(ABC) transporter
GR130_RS07905	COG2197	response regulator
GR130_RS07910	COG1132	(ABC) transporter
GR130_RS07925	COG0515	serine threonine protein kinase
GR130_RS07930	COG4585	Histidine kinase
GR130_RS07935	COG2197	response regulator
GR130_RS07970	COG1205	dead DEAH box helicase
GR130_RS07970	COG1111	helicase
GR130_RS07975	COG0210	DNA helicase
GR130_RS08010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GR130_RS08020	COG1181	Belongs to the D-alanine--D-alanine ligase family
GR130_RS08025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GR130_RS08120	COG3328	transposase activity
GR130_RS08305	COG1271	oxidase subunit
GR130_RS08320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR130_RS08340	COG2318	DinB family
GR130_RS08355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS08455	COG0803	Belongs to the bacterial solute-binding protein 9 family
GR130_RS08460	COG1121	(ABC) transporter
GR130_RS08495	COG0640	Transcriptional regulator
GR130_RS08510	COG0523	cobalamin synthesis protein
GR130_RS08535	COG0745	RESPONSE REGULATOR receiver
GR130_RS08545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GR130_RS08550	COG0019	diaminopimelate decarboxylase activity
GR130_RS08565	COG0523	cobalamin synthesis protein
GR130_RS08585	COG0735	belongs to the Fur family
GR130_RS08590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GR130_RS08595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GR130_RS08600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GR130_RS08605	COG0254	rRNA binding
GR130_RS08615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GR130_RS08620	COG0523	cobalamin synthesis protein
GR130_RS08630	COG0789	Transcriptional regulator
GR130_RS08635	COG2807	transmembrane transport
GR130_RS08710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GR130_RS08715	COG3321	synthase
GR130_RS08715	COG0604	alcohol dehydrogenase
GR130_RS08745	COG0583	DNA-binding transcription factor activity
GR130_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS08775	COG2814	Major facilitator Superfamily
GR130_RS08780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GR130_RS08840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GR130_RS08845	COG2186	Transcriptional regulator
GR130_RS08860	COG1175	transmembrane transport
GR130_RS08880	COG1994	Peptidase M50
GR130_RS08900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GR130_RS08905	COG0477	Major facilitator Superfamily
GR130_RS08910	COG1309	transcriptional regulator
GR130_RS08920	COG2814	Major facilitator Superfamily
GR130_RS08925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR130_RS08925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GR130_RS08930	COG2132	Multicopper oxidase
GR130_RS08945	COG2267	carboxylic ester hydrolase activity
GR130_RS08950	COG0174	glutamine synthetase
GR130_RS08965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GR130_RS08980	COG0366	Alpha amylase catalytic
GR130_RS08985	COG2182	Extracellular solute-binding protein
GR130_RS08990	COG1175	transmembrane transport
GR130_RS08995	COG3833	ABC-type maltose transport systems, permease component
GR130_RS09000	COG0366	Alpha amylase catalytic
GR130_RS09080	COG0745	RESPONSE REGULATOR receiver
GR130_RS09100	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS09140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GR130_RS09145	COG0321	lipoyl(octanoyl) transferase activity
GR130_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS09185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GR130_RS09195	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR130_RS09200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GR130_RS09205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GR130_RS09210	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GR130_RS09220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GR130_RS09220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GR130_RS09225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GR130_RS09255	COG4585	Histidine kinase
GR130_RS09260	COG2197	response regulator
GR130_RS09265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GR130_RS09270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GR130_RS09275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GR130_RS09305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GR130_RS09310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GR130_RS09330	COG1845	cytochrome c oxidase, subunit III
GR130_RS09335	COG2010	Cytochrome c
GR130_RS09340	COG0723	plastoquinol--plastocyanin reductase activity
GR130_RS09345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GR130_RS09350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GR130_RS09355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GR130_RS09400	COG0438	transferase activity, transferring glycosyl groups
GR130_RS09420	COG0003	Pfam Anion-transporting ATPase
GR130_RS09430	COG1940	carbohydrate kinase activity
GR130_RS09460	COG2197	response regulator
GR130_RS09465	COG0205	6-phosphofructokinase activity
GR130_RS09470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GR130_RS09480	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GR130_RS09490	COG2193	ferroxidase activity
GR130_RS09495	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GR130_RS09500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GR130_RS09505	COG2815	serine threonine protein kinase
GR130_RS09505	COG0515	serine threonine protein kinase
GR130_RS09515	COG2022	thiamine diphosphate biosynthetic process
GR130_RS09525	COG2022	thiamine diphosphate biosynthetic process
GR130_RS09525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR130_RS09540	COG0352	thiamine-phosphate diphosphorylase activity
GR130_RS09555	COG1233	COG1233 Phytoene dehydrogenase and related
GR130_RS09565	COG1309	transcriptional regulator
GR130_RS09575	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GR130_RS09585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GR130_RS09605	COG0714	Associated with various cellular activities
GR130_RS09615	COG0275	rRNA processing
GR130_RS09630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GR130_RS09640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GR130_RS09645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GR130_RS09655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GR130_RS09660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GR130_RS09680	COG1799	cell septum assembly
GR130_RS09690	COG3599	regulation of cell shape
GR130_RS09695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GR130_RS09700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GR130_RS09705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GR130_RS09745	COG0587	DNA-directed DNA polymerase activity
GR130_RS09750	COG1432	Conserved Protein
GR130_RS09770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GR130_RS09785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GR130_RS09790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GR130_RS09795	COG0131	Imidazoleglycerol-phosphate dehydratase
GR130_RS09800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GR130_RS09805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GR130_RS09810	COG0251	oxidation-reduction process
GR130_RS09815	COG0107	imidazoleglycerol-phosphate synthase activity
GR130_RS09820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GR130_RS09825	COG1053	succinate dehydrogenase
GR130_RS09835	COG0583	DNA-binding transcription factor activity
GR130_RS09850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GR130_RS09875	COG0134	indole-3-glycerol-phosphate synthase activity
GR130_RS09880	COG0133	tryptophan synthase activity
GR130_RS09885	COG0159	tryptophan synthase activity
GR130_RS09895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GR130_RS09905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR130_RS09935	COG0070	glutamate synthase
GR130_RS09935	COG0067	glutamate synthase
GR130_RS09935	COG0069	glutamate synthase activity
GR130_RS09950	COG0640	Transcriptional regulator
GR130_RS09955	COG3467	pyridoxamine 5'-phosphate
GR130_RS09965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GR130_RS09970	COG2267	carboxylic ester hydrolase activity
GR130_RS10000	COG0737	Belongs to the 5'-nucleotidase family
GR130_RS10030	COG0410	ABC transporter
GR130_RS10035	COG0411	ABC transporter
GR130_RS10045	COG0559	Belongs to the binding-protein-dependent transport system permease family
GR130_RS10055	COG2050	protein possibly involved in aromatic compounds catabolism
GR130_RS10090	COG1643	Atp-dependent helicase
GR130_RS10095	COG2226	methyltransferase
GR130_RS10100	COG0539	negative regulation of cytoplasmic translation
GR130_RS10110	COG0237	dephospho-CoA kinase activity
GR130_RS10140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GR130_RS10215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GR130_RS10220	COG0584	glycerophosphoryl diester phosphodiesterase
GR130_RS10225	COG0556	nucleotide-excision repair
GR130_RS10230	COG0861	Integral membrane protein TerC family
GR130_RS10235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GR130_RS10255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GR130_RS10265	COG1609	Transcriptional regulator
GR130_RS10295	COG0322	excinuclease ABC activity
GR130_RS10300	COG1660	Displays ATPase and GTPase activities
GR130_RS10305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GR130_RS10310	COG1481	regulation of sporulation
GR130_RS10315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GR130_RS10320	COG0126	phosphoglycerate kinase activity
GR130_RS10325	COG0149	triose-phosphate isomerase activity
GR130_RS10330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GR130_RS10345	COG0166	Belongs to the GPI family
GR130_RS10350	COG0363	glucosamine-6-phosphate deaminase activity
GR130_RS10365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GR130_RS10370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GR130_RS10375	COG0109	protoheme IX farnesyltransferase activity
GR130_RS10390	COG1612	heme a metabolic process
GR130_RS10415	COG0719	Fe-S assembly protein
GR130_RS10425	COG0396	ATPase activity
GR130_RS10430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GR130_RS10435	COG0822	iron-sulfur transferase activity
GR130_RS10440	COG2151	metal-sulfur cluster biosynthetic enzyme
GR130_RS10445	COG2076	Multidrug Resistance protein
GR130_RS10450	COG3226	Transcriptional regulator
GR130_RS10455	COG2171	N-acyltransferase activity
GR130_RS10465	COG2226	methyltransferase
GR130_RS10470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS10480	COG2261	transglycosylase associated protein
GR130_RS10485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GR130_RS10490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GR130_RS10510	COG2197	response regulator
GR130_RS10515	COG4585	Histidine kinase
GR130_RS10525	COG1414	Transcriptional regulator
GR130_RS10560	COG1917	Cupin 2, conserved barrel domain protein
GR130_RS10565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GR130_RS10600	COG1797	cobyrinic acid a,c-diamide synthase activity
GR130_RS10615	COG1492	cobalamin metabolic process
GR130_RS10620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GR130_RS10635	COG1653	transport
GR130_RS10650	COG0235	Class ii aldolase
GR130_RS10670	COG0488	(ABC) transporter
GR130_RS10680	COG1024	Enoyl-CoA hydratase
GR130_RS10715	COG3387	PFAM Glycoside hydrolase 15-related
GR130_RS10730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GR130_RS10745	COG0300	oxidoreductase activity
GR130_RS10785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR130_RS10790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GR130_RS10805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GR130_RS10820	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS10825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GR130_RS10830	COG2186	Transcriptional regulator
GR130_RS10850	COG3830	Belongs to the UPF0237 family
GR130_RS10850	COG0560	Phosphoserine phosphatase
GR130_RS10855	COG1716	ATPase activity
GR130_RS10855	COG1131	(ABC) transporter
GR130_RS10855	COG0842	Transport permease protein
GR130_RS10870	COG4585	Histidine kinase
GR130_RS10875	COG2197	response regulator
GR130_RS10895	COG1119	ATPase activity
GR130_RS10920	COG1881	PFAM PEBP family protein
GR130_RS10925	COG2094	Belongs to the DNA glycosylase MPG family
GR130_RS10960	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GR130_RS10975	COG0647	UMP catabolic process
GR130_RS10990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR130_RS10995	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR130_RS11000	COG1120	ATPase activity
GR130_RS11020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GR130_RS11035	COG0497	DNA recombination
GR130_RS11060	COG3387	PFAM Glycoside hydrolase 15-related
GR130_RS11065	COG0504	CTP synthase activity
GR130_RS11070	COG0494	nUDIX hydrolase
GR130_RS11080	COG0686	Belongs to the AlaDH PNT family
GR130_RS11095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GR130_RS11100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GR130_RS11105	COG1187	pseudouridine synthase activity
GR130_RS11115	COG3541	Predicted nucleotidyltransferase
GR130_RS11135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GR130_RS11145	COG1160	GTP binding
GR130_RS11175	COG0789	Transcriptional regulator
GR130_RS11185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GR130_RS11195	COG0671	phosphoesterase, PA-phosphatase related
GR130_RS11205	COG0477	Major facilitator Superfamily
GR130_RS11210	COG1960	acyl-CoA dehydrogenase activity
GR130_RS11215	COG1799	cell septum assembly
GR130_RS11220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR130_RS11245	COG1126	abc transporter atp-binding protein
GR130_RS11255	COG0330	HflC and HflK could
GR130_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS11285	COG0587	DNA-directed DNA polymerase activity
GR130_RS11290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GR130_RS11300	COG0531	amino acid
GR130_RS11305	COG1522	sequence-specific DNA binding
GR130_RS11330	COG0367	asparagine synthase
GR130_RS11335	COG1725	Transcriptional regulator
GR130_RS11340	COG1834	amidinotransferase
GR130_RS11370	COG1215	transferase activity, transferring glycosyl groups
GR130_RS11375	COG0463	Glycosyl transferase, family 2
GR130_RS11410	COG2814	Major facilitator Superfamily
GR130_RS11410	COG0477	Major facilitator Superfamily
GR130_RS11420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GR130_RS11425	COG1309	transcriptional regulator
GR130_RS11445	COG1960	acyl-CoA dehydrogenase activity
GR130_RS11490	COG0477	Major facilitator Superfamily
GR130_RS11495	COG1191	sigma factor activity
GR130_RS11500	COG3876	Protein conserved in bacteria
GR130_RS11510	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS11515	COG1309	transcriptional regulator
GR130_RS11520	COG1960	acyl-CoA dehydrogenase activity
GR130_RS11535	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GR130_RS11575	COG2205	protein histidine kinase activity
GR130_RS11590	COG2124	cytochrome p450
GR130_RS11595	COG0488	(ABC) transporter
GR130_RS11610	COG1902	pentaerythritol trinitrate reductase activity
GR130_RS11640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR130_RS11670	COG0667	Aldo Keto reductase
GR130_RS11675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS11685	COG0598	Magnesium transport protein CorA
GR130_RS11705	COG0215	cysteine-tRNA ligase activity
GR130_RS11715	COG4948	Mandelate Racemase Muconate Lactonizing
GR130_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS11730	COG1129	ABC transporter
GR130_RS11735	COG4211	Belongs to the binding-protein-dependent transport system permease family
GR130_RS11745	COG3618	amidohydrolase
GR130_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS11755	COG2186	Transcriptional regulator
GR130_RS11760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS11765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GR130_RS11770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GR130_RS11775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GR130_RS11780	COG1414	Transcriptional regulator
GR130_RS11785	COG1410	methionine synthase
GR130_RS11785	COG0646	methionine synthase
GR130_RS11790	COG0546	phosphoglycolate phosphatase activity
GR130_RS11795	COG4166	transmembrane transport
GR130_RS11800	COG4166	transmembrane transport
GR130_RS11805	COG2197	response regulator
GR130_RS11815	COG0517	IMP dehydrogenase activity
GR130_RS11815	COG1994	Peptidase M50
GR130_RS11835	COG1222	aaa ATPase
GR130_RS11840	COG4122	O-methyltransferase activity
GR130_RS11855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GR130_RS11860	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GR130_RS11865	COG1609	Transcriptional regulator
GR130_RS11875	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GR130_RS11880	COG0544	peptidyl-prolyl cis-trans isomerase activity
GR130_RS11890	COG2378	regulation of single-species biofilm formation
GR130_RS11910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GR130_RS11915	COG0805	protein transport
GR130_RS11925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS11930	COG3964	amidohydrolase
GR130_RS11970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GR130_RS11990	COG2233	PERMEase
GR130_RS12005	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GR130_RS12010	COG0531	amino acid
GR130_RS12015	COG2186	Transcriptional regulator
GR130_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS12060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GR130_RS12070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GR130_RS12075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GR130_RS12080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GR130_RS12085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GR130_RS12090	COG5002	protein histidine kinase activity
GR130_RS12095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GR130_RS12100	COG0072	phenylalanine-tRNA ligase activity
GR130_RS12100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR130_RS12150	COG0367	asparagine synthase
GR130_RS12155	COG0640	Transcriptional regulator
GR130_RS12175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GR130_RS12190	COG0505	Belongs to the CarA family
GR130_RS12205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GR130_RS12220	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GR130_RS12225	COG3145	DNA-N1-methyladenine dioxygenase activity
GR130_RS12260	COG1649	PFAM Uncharacterised BCR, COG1649
GR130_RS12270	COG0697	spore germination
GR130_RS12290	COG4106	trans-aconitate 2-methyltransferase activity
GR130_RS12310	COG4221	oxidoreductase activity
GR130_RS12330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GR130_RS12335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GR130_RS12340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GR130_RS12345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GR130_RS12350	COG1438	arginine binding
GR130_RS12370	COG0137	argininosuccinate synthase activity
GR130_RS12375	COG0165	Argininosuccinate lyase
GR130_RS12385	COG0477	Major facilitator Superfamily
GR130_RS12420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GR130_RS12425	COG2011	ABC-type metal ion transport system permease component
GR130_RS12430	COG1464	Belongs to the NlpA lipoprotein family
GR130_RS12445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GR130_RS12450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GR130_RS12450	COG1648	precorrin-2 dehydrogenase activity
GR130_RS12460	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GR130_RS12460	COG0515	serine threonine protein kinase
GR130_RS12495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GR130_RS12545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GR130_RS12560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GR130_RS12595	COG1560	Kdo2-lipid A biosynthetic process
GR130_RS12600	COG0438	transferase activity, transferring glycosyl groups
GR130_RS12610	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GR130_RS12615	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GR130_RS12620	COG0217	transcriptional regulatory protein
GR130_RS12625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GR130_RS12630	COG0632	four-way junction helicase activity
GR130_RS12635	COG2255	four-way junction helicase activity
GR130_RS12645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GR130_RS12650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GR130_RS12655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GR130_RS12660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GR130_RS12680	COG1196	nuclear chromosome segregation
GR130_RS12685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GR130_RS12695	COG0124	histidyl-tRNA synthetase
GR130_RS12715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GR130_RS12735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GR130_RS12740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GR130_RS12750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GR130_RS12755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GR130_RS12760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GR130_RS12765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GR130_RS12770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GR130_RS12780	COG0006	proline dipeptidase activity
GR130_RS12785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GR130_RS12790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GR130_RS12800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GR130_RS12805	COG0540	Belongs to the ATCase OTCase family
GR130_RS12810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR130_RS12820	COG0505	Belongs to the CarA family
GR130_RS12825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GR130_RS12830	COG0167	dihydroorotate dehydrogenase activity
GR130_RS12835	COG0284	orotidine-5'-phosphate decarboxylase activity
GR130_RS12860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GR130_RS12875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GR130_RS12885	COG2838	Isocitrate dehydrogenase
GR130_RS12890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GR130_RS12895	COG2390	Transcriptional regulator
GR130_RS12915	COG0531	amino acid
GR130_RS12930	COG0477	Major facilitator Superfamily
GR130_RS12940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR130_RS12955	COG2233	PERMEase
GR130_RS12980	COG1278	Cold shock
GR130_RS12990	COG2223	nitrite transmembrane transporter activity
GR130_RS12995	COG1090	epimerase
GR130_RS13010	COG3201	nicotinamide mononucleotide transporter
GR130_RS13015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GR130_RS13015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GR130_RS13020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GR130_RS13025	COG0140	phosphoribosyl-ATP diphosphatase activity
GR130_RS13030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GR130_RS13070	COG0285	dihydrofolate synthase activity
GR130_RS13250	COG1309	transcriptional regulator
GR130_RS13260	COG0667	Aldo Keto reductase
GR130_RS13280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GR130_RS13290	COG0667	Aldo Keto reductase
GR130_RS13340	COG0584	glycerophosphoryl diester phosphodiesterase
GR130_RS13360	COG5504	Zn-dependent protease
GR130_RS13400	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GR130_RS13410	COG2318	DinB family
GR130_RS13470	COG4585	Histidine kinase
GR130_RS13475	COG2197	response regulator
GR130_RS13485	COG2223	nitrite transmembrane transporter activity
GR130_RS13490	COG1940	carbohydrate kinase activity
GR130_RS13615	COG1349	DNA-binding transcription factor activity
GR130_RS13625	COG0464	growth
GR130_RS13645	COG0633	Ferredoxin
GR130_RS13645	COG3217	Mosc domain protein beta barrel domain protein
GR130_RS13660	COG0463	Glycosyl transferase, family 2
GR130_RS13665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GR130_RS13685	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS13720	COG0590	tRNA wobble adenosine to inosine editing
GR130_RS13725	COG3224	Antibiotic biosynthesis monooxygenase
GR130_RS13735	COG1793	dna ligase
GR130_RS13745	COG1063	alcohol dehydrogenase
GR130_RS13750	COG0395	ABC-type sugar transport system, permease component
GR130_RS13790	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS13810	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GR130_RS13815	COG1461	Dihydroxyacetone kinase
GR130_RS13820	COG2376	Dihydroxyacetone kinase
GR130_RS13830	COG0110	maltose O-acetyltransferase activity
GR130_RS13850	COG2197	response regulator
GR130_RS13860	COG0596	Alpha beta hydrolase
GR130_RS13865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GR130_RS13880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GR130_RS13895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS13910	COG1960	acyl-CoA dehydrogenase activity
GR130_RS13920	COG0515	serine threonine protein kinase
GR130_RS13935	COG2070	2-Nitropropane dioxygenase
GR130_RS13950	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS14000	COG2272	Belongs to the type-B carboxylesterase lipase family
GR130_RS14010	COG0259	pyridoxamine-phosphate oxidase activity
GR130_RS14055	COG0438	transferase activity, transferring glycosyl groups
GR130_RS14070	COG1984	allophanate hydrolase subunit 2
GR130_RS14075	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GR130_RS14080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GR130_RS14105	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GR130_RS14145	COG2146	nitrite reductase [NAD(P)H] activity
GR130_RS14175	COG1309	transcriptional regulator
GR130_RS14185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GR130_RS14190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GR130_RS14205	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GR130_RS14215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GR130_RS14225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GR130_RS14255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GR130_RS14275	COG1716	ATPase activity
GR130_RS14295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GR130_RS14305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GR130_RS14305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GR130_RS14340	COG1695	Transcriptional regulator
GR130_RS14395	COG0697	spore germination
GR130_RS14405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GR130_RS14405	COG0825	malonyl-CoA metabolic process
GR130_RS14410	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS14430	COG0431	NADPH-dependent FMN reductase
GR130_RS14440	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS14445	COG0667	Aldo Keto reductase
GR130_RS14450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GR130_RS14470	COG0673	inositol 2-dehydrogenase activity
GR130_RS14485	COG1132	(ABC) transporter
GR130_RS14535	COG0662	Cupin 2, conserved barrel domain protein
GR130_RS14545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS14550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS14615	COG0438	transferase activity, transferring glycosyl groups
GR130_RS14640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GR130_RS14660	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GR130_RS14710	COG3835	regulator
GR130_RS14715	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GR130_RS14720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR130_RS14720	COG2080	2 iron, 2 sulfur cluster binding
GR130_RS14735	COG3585	molybdate ion transport
GR130_RS14775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GR130_RS14775	COG1024	Enoyl-CoA hydratase
GR130_RS14780	COG0745	RESPONSE REGULATOR receiver
GR130_RS14810	COG2318	DinB family
GR130_RS14835	COG1063	alcohol dehydrogenase
GR130_RS14840	COG0156	8-amino-7-oxononanoate synthase activity
GR130_RS14845	COG0583	DNA-binding transcription factor activity
GR130_RS14850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GR130_RS14850	COG1796	DNA polymerase
GR130_RS14865	COG2274	protein secretion by the type I secretion system
GR130_RS14960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GR130_RS15005	COG0076	glutamate decarboxylase activity
GR130_RS15025	COG1309	transcriptional regulator
GR130_RS15050	COG0772	Belongs to the SEDS family
GR130_RS15060	COG0531	amino acid
GR130_RS15065	COG2267	carboxylic ester hydrolase activity
GR130_RS15075	COG2318	DinB family
GR130_RS15100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GR130_RS15125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS15160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GR130_RS15185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS15190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS15195	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR130_RS15205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR130_RS15210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS15230	COG0494	nUDIX hydrolase
GR130_RS15265	COG0405	Gamma-glutamyltransferase
GR130_RS15280	COG1116	anion transmembrane transporter activity
GR130_RS15335	COG2188	Transcriptional regulator
GR130_RS15415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GR130_RS15425	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GR130_RS15430	COG0531	amino acid
GR130_RS15470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR130_RS15485	COG0640	Transcriptional regulator
GR130_RS15500	COG1113	amino acid transport
GR130_RS15505	COG2186	Transcriptional regulator
GR130_RS15515	COG2318	DinB family
GR130_RS15530	COG0583	DNA-binding transcription factor activity
GR130_RS15535	COG4565	transcriptional regulatory protein
GR130_RS15540	COG3290	protein histidine kinase activity
GR130_RS15550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GR130_RS15585	COG0596	Alpha beta hydrolase
GR130_RS15620	COG0542	response to heat
GR130_RS15640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GR130_RS15645	COG1733	regulation of RNA biosynthetic process
GR130_RS15655	COG0454	-acetyltransferase
GR130_RS15725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR130_RS15770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GR130_RS15800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR130_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS15810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR130_RS15820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS15840	COG0009	L-threonylcarbamoyladenylate synthase
GR130_RS15895	COG0071	Belongs to the small heat shock protein (HSP20) family
GR130_RS15925	COG2239	Acts as a magnesium transporter
GR130_RS16015	COG2205	protein histidine kinase activity
GR130_RS16025	COG0488	(ABC) transporter
GR130_RS16040	COG0477	Major facilitator Superfamily
GR130_RS16045	COG0583	DNA-binding transcription factor activity
GR130_RS16065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS16115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS16130	COG0596	Alpha beta hydrolase
GR130_RS16135	COG3226	Transcriptional regulator
GR130_RS16145	COG2249	NAD(P)H dehydrogenase (quinone) activity
GR130_RS16165	COG0667	Aldo Keto reductase
GR130_RS16195	COG2205	protein histidine kinase activity
GR130_RS16205	COG2326	polyphosphate kinase activity
GR130_RS16210	COG0517	IMP dehydrogenase activity
GR130_RS16210	COG0516	GMP reductase activity
GR130_RS16215	COG0516	GMP reductase activity
GR130_RS16215	COG0517	IMP dehydrogenase activity
GR130_RS16220	COG1042	CoA-binding domain protein
GR130_RS16220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR130_RS16220	COG0045	succinate-CoA ligase (ADP-forming) activity
GR130_RS16280	COG3903	Transcriptional regulator
GR130_RS16280	COG3629	intracellular signal transduction
GR130_RS16375	COG1140	nitrate reductase beta subunit
GR130_RS16405	COG1595	DNA-templated transcription, initiation
GR130_RS16460	COG0154	amidase activity
GR130_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS16530	COG0583	DNA-binding transcription factor activity
GR130_RS16540	COG0667	Aldo Keto reductase
GR130_RS16545	COG2814	Major facilitator Superfamily
GR130_RS16640	COG0583	DNA-binding transcription factor activity
GR130_RS16665	COG1017	nitric oxide dioxygenase activity
GR130_RS16665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GR130_RS16670	COG0745	RESPONSE REGULATOR receiver
GR130_RS16675	COG2205	protein histidine kinase activity
GR130_RS16680	COG0516	GMP reductase activity
GR130_RS16680	COG0517	IMP dehydrogenase activity
GR130_RS16700	COG2226	methyltransferase
GR130_RS16735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GR130_RS16750	COG0697	spore germination
GR130_RS16800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR130_RS16800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GR130_RS16810	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS16995	COG2135	peptidase activity
GR130_RS17010	COG2318	DinB family
GR130_RS17035	COG1254	Belongs to the acylphosphatase family
GR130_RS17050	COG0531	amino acid
GR130_RS17060	COG1121	(ABC) transporter
GR130_RS17115	COG0789	Transcriptional regulator
GR130_RS17145	COG0395	ABC-type sugar transport system, permease component
GR130_RS17160	COG1349	DNA-binding transcription factor activity
GR130_RS17165	COG3321	synthase
GR130_RS17165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS17175	COG2409	Drug exporters of the RND superfamily
GR130_RS17215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR130_RS17255	COG2423	ornithine cyclodeaminase activity
GR130_RS17285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GR130_RS17285	COG2070	2-Nitropropane dioxygenase
GR130_RS17310	COG3795	YCII-related domain
GR130_RS17315	COG4941	Belongs to the sigma-70 factor family
GR130_RS17325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GR130_RS17365	COG1309	transcriptional regulator
GR130_RS17380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GR130_RS17395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GR130_RS17400	COG2364	Membrane
GR130_RS17405	COG0436	Aminotransferase
GR130_RS17430	COG1234	tRNA 3'-trailer cleavage
GR130_RS17450	COG3903	Transcriptional regulator
GR130_RS17450	COG3629	intracellular signal transduction
GR130_RS17470	COG0542	response to heat
GR130_RS17475	COG2264	protein methyltransferase activity
GR130_RS17485	COG2226	methyltransferase
GR130_RS17490	COG4585	Histidine kinase
GR130_RS17495	COG2197	response regulator
GR130_RS17500	COG0577	efflux transmembrane transporter activity
GR130_RS17500	COG1136	(ABC) transporter
GR130_RS17505	COG0577	efflux transmembrane transporter activity
GR130_RS17505	COG1136	(ABC) transporter
GR130_RS17580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GR130_RS17605	COG1819	glycosyl
GR130_RS17625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GR130_RS17635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GR130_RS17640	COG4221	oxidoreductase activity
GR130_RS17655	COG0180	Tryptophanyl-tRNA synthetase
GR130_RS17665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GR130_RS17685	COG0243	molybdopterin cofactor binding
GR130_RS17705	COG3321	synthase
GR130_RS17705	COG0604	alcohol dehydrogenase
GR130_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS17715	COG3963	phosphatidate phosphatase activity
GR130_RS17720	COG0604	alcohol dehydrogenase
GR130_RS17795	COG0483	inositol monophosphate 1-phosphatase activity
GR130_RS17830	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS17860	COG0243	molybdopterin cofactor binding
GR130_RS17880	COG0517	IMP dehydrogenase activity
GR130_RS17880	COG0516	GMP reductase activity
GR130_RS17885	COG1042	CoA-binding domain protein
GR130_RS17885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR130_RS17885	COG0045	succinate-CoA ligase (ADP-forming) activity
GR130_RS17975	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR130_RS17980	COG0022	dehydrogenase e1 component
GR130_RS17980	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR130_RS17985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GR130_RS17990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GR130_RS18010	COG0330	HflC and HflK could
GR130_RS18025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GR130_RS18030	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GR130_RS18060	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GR130_RS18080	COG1269	ATP hydrolysis coupled proton transport
GR130_RS18115	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GR130_RS18160	COG2259	Doxx family
GR130_RS18170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GR130_RS18180	COG2223	nitrite transmembrane transporter activity
GR130_RS18190	COG2018	Roadblock/LC7 domain
GR130_RS18270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GR130_RS18300	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GR130_RS18310	COG3145	DNA-N1-methyladenine dioxygenase activity
GR130_RS18360	COG1794	racemase activity, acting on amino acids and derivatives
GR130_RS18420	COG0583	DNA-binding transcription factor activity
GR130_RS18460	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
GR130_RS18470	COG0110	maltose O-acetyltransferase activity
GR130_RS18480	COG0789	Transcriptional regulator
GR130_RS18515	COG2226	methyltransferase
GR130_RS18540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GR130_RS18545	COG3387	PFAM Glycoside hydrolase 15-related
GR130_RS18555	COG0477	Major facilitator Superfamily
GR130_RS18585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR130_RS18600	COG0542	response to heat
GR130_RS18605	COG2124	cytochrome p450
GR130_RS18610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR130_RS18675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR130_RS18705	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GR130_RS18720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GR130_RS18730	COG0504	CTP synthase activity
GR130_RS18745	COG4978	Transcriptional regulator
GR130_RS18745	COG0789	Transcriptional regulator
GR130_RS18750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS18785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GR130_RS18800	COG2826	transposase and inactivated derivatives, IS30 family
GR130_RS18845	COG2801	Transposase and inactivated derivatives
GR130_RS18875	COG2945	thiolester hydrolase activity
GR130_RS18875	COG0596	Alpha beta hydrolase
GR130_RS18950	COG0488	(ABC) transporter
GR130_RS18970	COG3251	PFAM MbtH domain protein
GR130_RS18985	COG0789	Transcriptional regulator
GR130_RS18990	COG2226	methyltransferase
GR130_RS18990	COG1073	alpha beta
GR130_RS19010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS19120	COG0726	polysaccharide deacetylase
GR130_RS19130	COG2824	Alkylphosphonate utilization operon protein PhnA
GR130_RS19185	COG2826	transposase and inactivated derivatives, IS30 family
GR130_RS19210	COG2807	transmembrane transport
GR130_RS19240	COG4974	Belongs to the 'phage' integrase family
GR130_RS19265	COG2199	diguanylate cyclase activity
GR130_RS19410	COG2801	Transposase and inactivated derivatives
GR130_RS19425	COG1196	nuclear chromosome segregation
GR130_RS19425	COG0739	heme binding
GR130_RS19425	COG0741	lytic transglycosylase activity
GR130_RS19460	COG0640	Transcriptional regulator
GR130_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS19570	COG3631	Ketosteroid isomerase-related protein
GR130_RS19575	COG0702	epimerase
GR130_RS19590	COG1309	transcriptional regulator
GR130_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS19620	COG3387	PFAM Glycoside hydrolase 15-related
GR130_RS19680	COG1231	oxidoreductase activity
GR130_RS19705	COG5002	protein histidine kinase activity
GR130_RS19710	COG0745	RESPONSE REGULATOR receiver
GR130_RS19755	COG0583	DNA-binding transcription factor activity
GR130_RS19835	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GR130_RS19855	COG2205	protein histidine kinase activity
GR130_RS19860	COG0745	RESPONSE REGULATOR receiver
GR130_RS19980	COG2801	Transposase and inactivated derivatives
GR130_RS20075	COG1309	transcriptional regulator
GR130_RS20205	COG2124	cytochrome p450
GR130_RS20210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR130_RS20215	COG3415	Transposase
GR130_RS20215	COG2801	Transposase and inactivated derivatives
GR130_RS20245	COG1522	sequence-specific DNA binding
GR130_RS20260	COG0745	RESPONSE REGULATOR receiver
GR130_RS20280	COG4249	Peptidase C14 caspase catalytic subunit p20
GR130_RS20280	COG2319	Wd-40 repeat
GR130_RS20300	COG2197	response regulator
GR130_RS20305	COG4585	Histidine kinase
GR130_RS20370	COG3903	Transcriptional regulator
GR130_RS20370	COG2197	response regulator
GR130_RS20395	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS20455	COG2070	2-Nitropropane dioxygenase
GR130_RS20465	COG2197	response regulator
GR130_RS20470	COG4585	Histidine kinase
GR130_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS20525	COG2205	protein histidine kinase activity
GR130_RS20530	COG2815	serine threonine protein kinase
GR130_RS20530	COG0515	serine threonine protein kinase
GR130_RS20550	COG0148	phosphopyruvate hydratase activity
GR130_RS20585	COG3328	transposase activity
GR130_RS20620	COG4977	sequence-specific DNA binding
GR130_RS20675	COG3335	DDE superfamily endonuclease
GR130_RS20705	COG3328	transposase activity
GR130_RS20725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GR130_RS20730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GR130_RS20760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR130_RS20805	COG0604	alcohol dehydrogenase
GR130_RS20805	COG3321	synthase
GR130_RS20805	COG0604	alcohol dehydrogenase
GR130_RS20805	COG3321	synthase
GR130_RS20825	COG2197	response regulator
GR130_RS20830	COG4585	Histidine kinase
GR130_RS20920	COG0515	serine threonine protein kinase
GR130_RS20920	COG2815	serine threonine protein kinase
GR130_RS20965	COG2801	Transposase and inactivated derivatives
GR130_RS20965	COG3415	Transposase
GR130_RS20985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GR130_RS21005	COG2267	carboxylic ester hydrolase activity
GR130_RS21040	COG2226	methyltransferase
GR130_RS21065	COG0494	nUDIX hydrolase
GR130_RS21095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR130_RS21100	COG2267	carboxylic ester hydrolase activity
GR130_RS21125	COG0626	cystathionine gamma-synthase activity
GR130_RS21135	COG0513	Belongs to the DEAD box helicase family
GR130_RS21185	COG1309	transcriptional regulator
GR130_RS21200	COG2030	dehydratase
GR130_RS21200	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS21335	COG2268	Band 7 protein
GR130_RS21355	COG0596	Alpha beta hydrolase
GR130_RS21365	COG0583	DNA-binding transcription factor activity
GR130_RS21385	COG0577	efflux transmembrane transporter activity
GR130_RS21390	COG0577	efflux transmembrane transporter activity
GR130_RS21390	COG1136	(ABC) transporter
GR130_RS21395	COG2197	response regulator
GR130_RS21400	COG4585	Histidine kinase
GR130_RS21420	COG1846	Transcriptional regulator
GR130_RS21425	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS21445	COG0300	oxidoreductase activity
GR130_RS21455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS21490	COG1132	(ABC) transporter
GR130_RS21520	COG3321	synthase
GR130_RS21520	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS21520	COG0604	alcohol dehydrogenase
GR130_RS21540	COG0583	DNA-binding transcription factor activity
GR130_RS21550	COG4608	Belongs to the ABC transporter superfamily
GR130_RS21560	COG0601	transmembrane transport
GR130_RS21565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR130_RS21575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR130_RS21595	COG3938	Belongs to the proline racemase family
GR130_RS21605	COG1802	Transcriptional regulator
GR130_RS21620	COG0596	Alpha beta hydrolase
GR130_RS21625	COG1113	amino acid transport
GR130_RS21630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR130_RS21645	COG0028	Belongs to the TPP enzyme family
GR130_RS21655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GR130_RS21680	COG3903	Transcriptional regulator
GR130_RS21680	COG3629	intracellular signal transduction
GR130_RS21690	COG1116	anion transmembrane transporter activity
GR130_RS21695	COG0402	S-adenosylhomocysteine deaminase activity
GR130_RS21705	COG1024	Enoyl-CoA hydratase
GR130_RS21710	COG1024	Enoyl-CoA hydratase
GR130_RS21730	COG0189	ligase activity
GR130_RS21760	COG3973	AAA domain
GR130_RS21785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS21790	COG1335	isochorismatase
GR130_RS21805	COG1021	2,3-dihydroxybenzoate-AMP ligase
GR130_RS21830	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS21835	COG1309	transcriptional regulator
GR130_RS21855	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GR130_RS21870	COG0754	glutathionylspermidine amidase activity
GR130_RS21895	COG3226	Transcriptional regulator
GR130_RS21905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GR130_RS21930	COG5599	Phosphatase
GR130_RS21940	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GR130_RS21960	COG4221	oxidoreductase activity
GR130_RS21965	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GR130_RS21980	COG0137	argininosuccinate synthase activity
GR130_RS22010	COG0531	amino acid
GR130_RS22025	COG1129	ABC transporter
GR130_RS22030	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR130_RS22055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GR130_RS22060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR130_RS22070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GR130_RS22180	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS22220	COG1819	glycosyl
GR130_RS22225	COG0789	Transcriptional regulator
GR130_RS22235	COG1309	transcriptional regulator
GR130_RS22245	COG2814	Major facilitator Superfamily
GR130_RS22295	COG1131	(ABC) transporter
GR130_RS22295	COG1716	ATPase activity
GR130_RS22295	COG0842	Transport permease protein
GR130_RS22345	COG3345	alpha-galactosidase
GR130_RS22450	COG0805	protein transport
GR130_RS22455	COG1132	(ABC) transporter
GR130_RS22485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GR130_RS22505	COG0367	asparagine synthase
GR130_RS22540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GR130_RS22555	COG4310	Domain of unknown function (DUF2172)
GR130_RS22565	COG1216	Glycosyl transferase, family 2
GR130_RS22580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GR130_RS22600	COG0604	alcohol dehydrogenase
GR130_RS22600	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS22600	COG3321	synthase
GR130_RS22630	COG3328	transposase activity
GR130_RS22675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GR130_RS22690	COG0604	alcohol dehydrogenase
GR130_RS22690	COG3321	synthase
GR130_RS22690	COG3321	synthase
GR130_RS22690	COG0604	alcohol dehydrogenase
GR130_RS22715	COG0604	alcohol dehydrogenase
GR130_RS22715	COG3321	synthase
GR130_RS22745	COG2197	response regulator
GR130_RS22760	COG1132	(ABC) transporter
GR130_RS22780	COG0069	glutamate synthase activity
GR130_RS22845	COG0346	lactoylglutathione lyase activity
GR130_RS22895	COG0740	serine-type endopeptidase activity
GR130_RS22900	COG0740	serine-type endopeptidase activity
GR130_RS22930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GR130_RS22955	COG0076	glutamate decarboxylase activity
GR130_RS22970	COG2409	Drug exporters of the RND superfamily
GR130_RS22980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS22990	COG3842	ATPase activity
GR130_RS22995	COG0395	ABC-type sugar transport system, permease component
GR130_RS23005	COG1653	transport
GR130_RS23010	COG0366	Alpha amylase catalytic
GR130_RS23015	COG1653	transport
GR130_RS23020	COG1695	Transcriptional regulator
GR130_RS23025	COG0577	efflux transmembrane transporter activity
GR130_RS23025	COG1136	(ABC) transporter
GR130_RS23145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GR130_RS23160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GR130_RS23190	COG0667	Aldo Keto reductase
GR130_RS23215	COG2130	NADP-dependent
GR130_RS23220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GR130_RS23220	COG2070	2-Nitropropane dioxygenase
GR130_RS23225	COG3321	synthase
GR130_RS23225	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS23225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS23225	COG4221	oxidoreductase activity
GR130_RS23230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS23230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS23230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GR130_RS23230	COG3321	synthase
GR130_RS23230	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS23235	COG4221	oxidoreductase activity
GR130_RS23235	COG3321	synthase
GR130_RS23235	COG0300	oxidoreductase activity
GR130_RS23235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS23240	COG0367	asparagine synthase
GR130_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS23290	COG3851	Histidine kinase
GR130_RS23295	COG2197	response regulator
GR130_RS23305	COG1131	(ABC) transporter
GR130_RS23310	COG2814	Major facilitator Superfamily
GR130_RS23315	COG1733	regulation of RNA biosynthetic process
GR130_RS23330	COG3848	Pyruvate phosphate dikinase
GR130_RS23330	COG0574	Belongs to the PEP-utilizing enzyme family
GR130_RS23350	COG0372	Belongs to the citrate synthase family
GR130_RS23360	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS23365	COG0583	DNA-binding transcription factor activity
GR130_RS23395	COG3903	Transcriptional regulator
GR130_RS23395	COG3629	intracellular signal transduction
GR130_RS23405	COG0789	Transcriptional regulator
GR130_RS23415	COG1027	Aspartate ammonia-lyase
GR130_RS23420	COG0583	DNA-binding transcription factor activity
GR130_RS23430	COG0789	Transcriptional regulator
GR130_RS23440	COG3903	Transcriptional regulator
GR130_RS23440	COG3629	intracellular signal transduction
GR130_RS23455	COG0517	IMP dehydrogenase activity
GR130_RS23465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GR130_RS23470	COG1280	lysine exporter protein (LysE YggA)
GR130_RS23530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR130_RS23530	COG2010	Cytochrome c
GR130_RS23545	COG0590	tRNA wobble adenosine to inosine editing
GR130_RS23560	COG0583	DNA-binding transcription factor activity
GR130_RS23585	COG3291	Pkd domain containing protein
GR130_RS23590	COG0583	DNA-binding transcription factor activity
GR130_RS23595	COG0460	homoserine dehydrogenase
GR130_RS23610	COG4221	oxidoreductase activity
GR130_RS23620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR130_RS23625	COG2124	cytochrome p450
GR130_RS23630	COG3387	PFAM Glycoside hydrolase 15-related
GR130_RS23650	COG2814	Major facilitator Superfamily
GR130_RS23675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR130_RS23705	COG0701	Predicted permease
GR130_RS23715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR130_RS23720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GR130_RS23725	COG2080	2 iron, 2 sulfur cluster binding
GR130_RS23740	COG5634	Uncharacterized conserved protein (DUF2278)
GR130_RS23745	COG3409	Peptidoglycan-binding domain 1 protein
GR130_RS23745	COG3757	hydrolase, family 25
GR130_RS23765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GR130_RS23775	COG2814	Major facilitator Superfamily
GR130_RS23785	COG1063	alcohol dehydrogenase
GR130_RS23790	COG1070	Carbohydrate kinase
GR130_RS23795	COG3469	chitinase activity
GR130_RS23805	COG1073	alpha beta
GR130_RS23810	COG1819	glycosyl
GR130_RS23815	COG2197	response regulator
GR130_RS23820	COG4585	Histidine kinase
GR130_RS23840	COG0154	amidase activity
GR130_RS23875	COG0443	Heat shock 70 kDa protein
GR130_RS23880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GR130_RS23900	COG3851	Histidine kinase
GR130_RS23905	COG2197	response regulator
GR130_RS23950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS23995	COG0667	Aldo Keto reductase
GR130_RS24065	COG2837	iron assimilation
GR130_RS24085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GR130_RS24090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GR130_RS24140	COG0640	Transcriptional regulator
GR130_RS24145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GR130_RS24160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GR130_RS24180	COG2261	transglycosylase associated protein
GR130_RS24225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS24240	COG0436	Aminotransferase
GR130_RS24245	COG1509	lysine 2,3-aminomutase activity
GR130_RS24250	COG2192	nodulation
GR130_RS24255	COG1181	Belongs to the D-alanine--D-alanine ligase family
GR130_RS24265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GR130_RS24270	COG0477	Major facilitator Superfamily
GR130_RS24295	COG0477	Major facilitator Superfamily
GR130_RS24315	COG3511	phospholipase C
GR130_RS24345	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS24355	COG1024	Enoyl-CoA hydratase
GR130_RS24440	COG0183	Belongs to the thiolase family
GR130_RS24445	COG1309	transcriptional regulator
GR130_RS24450	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS24460	COG1024	Enoyl-CoA hydratase
GR130_RS24465	COG1960	acyl-CoA dehydrogenase activity
GR130_RS24505	COG3290	protein histidine kinase activity
GR130_RS24540	COG1793	dna ligase
GR130_RS24555	COG0531	amino acid
GR130_RS24560	COG0640	Transcriptional regulator
GR130_RS24590	COG0309	Hydrogenase expression formation protein (HypE)
GR130_RS24600	COG0298	carbon dioxide binding
GR130_RS24605	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GR130_RS24610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GR130_RS24615	COG0375	protein maturation
GR130_RS24645	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GR130_RS24660	COG0673	inositol 2-dehydrogenase activity
GR130_RS24665	COG0477	Major facilitator Superfamily
GR130_RS24685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GR130_RS24705	COG2084	Dehydrogenase
GR130_RS24710	COG3622	Belongs to the hyi family
GR130_RS24715	COG3960	tartronate-semialdehyde synthase activity
GR130_RS24740	COG4552	Acetyltransferase involved in intracellular survival and related
GR130_RS24765	COG1960	acyl-CoA dehydrogenase activity
GR130_RS24775	COG0242	peptide deformylase activity
GR130_RS24785	COG3442	glutamine amidotransferase
GR130_RS24790	COG0205	6-phosphofructokinase activity
GR130_RS24825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GR130_RS24830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GR130_RS24855	COG0829	nickel cation binding
GR130_RS24860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GR130_RS24865	COG0830	nickel cation binding
GR130_RS24870	COG0804	urea catabolic process
GR130_RS24875	COG0832	Belongs to the urease beta subunit family
GR130_RS24880	COG0831	urea catabolic process
GR130_RS24895	COG0740	serine-type endopeptidase activity
GR130_RS24905	COG0791	NLP P60 protein
GR130_RS24910	COG1280	lysine exporter protein (LysE YggA)
GR130_RS24915	COG0583	DNA-binding transcription factor activity
GR130_RS24925	COG0156	8-amino-7-oxononanoate synthase activity
GR130_RS24930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GR130_RS24935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GR130_RS24940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GR130_RS24980	COG0456	acetyltransferase
GR130_RS25010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GR130_RS25015	COG3663	DNA glycosylase
GR130_RS25025	COG1940	carbohydrate kinase activity
GR130_RS25030	COG2188	Transcriptional regulator
GR130_RS25040	COG1595	DNA-templated transcription, initiation
GR130_RS25050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS25075	COG1522	sequence-specific DNA binding
GR130_RS25080	COG0419	ATPase involved in DNA repair
GR130_RS25140	COG0531	amino acid
GR130_RS25145	COG1739	Uncharacterized protein family UPF0029
GR130_RS25155	COG1832	CoA-binding protein
GR130_RS25180	COG2171	N-acyltransferase activity
GR130_RS25190	COG1024	Enoyl-CoA hydratase
GR130_RS25195	COG2124	cytochrome p450
GR130_RS25200	COG2124	cytochrome p450
GR130_RS25265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GR130_RS25305	COG2208	phosphoserine phosphatase activity
GR130_RS25330	COG1764	response to oxidative stress
GR130_RS25335	COG1846	Transcriptional regulator
GR130_RS25345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS25380	COG0739	heme binding
GR130_RS25385	COG2197	response regulator
GR130_RS25390	COG4585	Histidine kinase
GR130_RS25405	COG1609	Transcriptional regulator
GR130_RS25415	COG4209	transmembrane transport
GR130_RS25420	COG0395	ABC-type sugar transport system, permease component
GR130_RS25460	COG1278	Cold shock
GR130_RS25465	COG1686	Belongs to the peptidase S11 family
GR130_RS25475	COG1793	dna ligase
GR130_RS25475	COG3285	dna ligase
GR130_RS25480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GR130_RS25485	COG3415	Transposase
GR130_RS25485	COG2801	Transposase and inactivated derivatives
GR130_RS25495	COG3012	SEC-C Motif Domain Protein
GR130_RS25525	COG2270	Major facilitator Superfamily
GR130_RS25535	COG3030	protein affecting phage T7 exclusion by the F plasmid
GR130_RS25540	COG1216	Glycosyl transferase, family 2
GR130_RS25550	COG1228	amidohydrolase
GR130_RS25575	COG1960	acyl-CoA dehydrogenase activity
GR130_RS25585	COG1309	transcriptional regulator
GR130_RS25605	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS25610	COG1132	(ABC) transporter
GR130_RS25650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GR130_RS25680	COG1609	Transcriptional regulator
GR130_RS25715	COG0308	aminopeptidase N
GR130_RS25735	COG1285	pathogenesis
GR130_RS25745	COG1309	transcriptional regulator
GR130_RS25765	COG1902	pentaerythritol trinitrate reductase activity
GR130_RS25775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GR130_RS25785	COG2971	BadF BadG BcrA BcrD
GR130_RS25845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GR130_RS25850	COG4213	ABC transporter substrate-binding protein
GR130_RS25890	COG1309	transcriptional regulator
GR130_RS25905	COG1473	amidohydrolase
GR130_RS25975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GR130_RS25980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR130_RS25990	COG0477	Major facilitator Superfamily
GR130_RS25995	COG0247	lactate metabolic process
GR130_RS26000	COG1139	Iron-sulfur cluster binding protein
GR130_RS26005	COG1556	Lactate utilization protein
GR130_RS26015	COG1132	(ABC) transporter
GR130_RS26050	COG1132	(ABC) transporter
GR130_RS26055	COG1132	(ABC) transporter
GR130_RS26070	COG1946	Acyl-CoA thioesterase
GR130_RS26080	COG2018	Roadblock/LC7 domain
GR130_RS26130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GR130_RS26140	COG2353	YceI-like domain
GR130_RS26145	COG2040	homocysteine
GR130_RS26155	COG3458	cephalosporin-C deacetylase activity
GR130_RS26165	COG1070	Carbohydrate kinase
GR130_RS26175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR130_RS26180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR130_RS26200	COG1376	ErfK ybiS ycfS ynhG family protein
GR130_RS26205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GR130_RS26205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GR130_RS26210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GR130_RS26215	COG0588	phosphoglycerate mutase activity
GR130_RS26220	COG1070	Carbohydrate kinase
GR130_RS26230	COG2814	Major facilitator Superfamily
GR130_RS26235	COG1349	DNA-binding transcription factor activity
GR130_RS26255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR130_RS26260	COG0601	transmembrane transport
GR130_RS26290	COG1960	acyl-CoA dehydrogenase activity
GR130_RS26295	COG1960	acyl-CoA dehydrogenase activity
GR130_RS26320	COG1733	regulation of RNA biosynthetic process
GR130_RS26330	COG3572	ergothioneine biosynthetic process
GR130_RS26335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GR130_RS26345	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GR130_RS26390	COG0531	amino acid
GR130_RS26395	COG3537	Alpha-1,2-mannosidase
GR130_RS26480	COG2706	6-phosphogluconolactonase activity
GR130_RS26490	COG3583	domain protein
GR130_RS26500	COG1960	acyl-CoA dehydrogenase activity
GR130_RS26505	COG1024	Enoyl-CoA hydratase
GR130_RS26525	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS26540	COG0174	glutamine synthetase
GR130_RS26565	COG1686	Belongs to the peptidase S11 family
GR130_RS26570	COG2124	cytochrome p450
GR130_RS26595	COG3959	Transketolase, thiamine diphosphate binding domain
GR130_RS26600	COG3958	Transketolase
GR130_RS26610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR130_RS26615	COG1960	acyl-CoA dehydrogenase activity
GR130_RS26635	COG2018	Roadblock/LC7 domain
GR130_RS26650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GR130_RS26680	COG2755	lipolytic protein G-D-S-L family
GR130_RS26685	COG2365	Tyrosine phosphatase family
GR130_RS26700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GR130_RS26715	COG1657	PFAM Prenyltransferase squalene oxidase
GR130_RS26725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GR130_RS26735	COG1562	ergosterol biosynthetic process
GR130_RS26740	COG1134	teichoic acid transport
GR130_RS26775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GR130_RS26820	COG2183	response to ionizing radiation
GR130_RS26840	COG2936	dipeptidyl-peptidase activity
GR130_RS26845	COG0308	aminopeptidase N
GR130_RS26865	COG1113	amino acid transport
GR130_RS26880	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR130_RS26880	COG1024	Enoyl-CoA hydratase
GR130_RS26885	COG0183	Belongs to the thiolase family
GR130_RS26890	COG1960	acyl-CoA dehydrogenase activity
GR130_RS26900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR130_RS26905	COG1285	pathogenesis
GR130_RS26915	COG3268	Saccharopine dehydrogenase
GR130_RS26920	COG1515	deoxyribonuclease V activity
GR130_RS26935	COG2814	Major facilitator Superfamily
GR130_RS26940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GR130_RS26950	COG1349	DNA-binding transcription factor activity
GR130_RS26960	COG1309	transcriptional regulator
GR130_RS26965	COG1289	transmembrane transporter activity
GR130_RS26970	COG1846	Transcriptional regulator
GR130_RS26980	COG3226	Transcriptional regulator
GR130_RS27005	COG0745	RESPONSE REGULATOR receiver
GR130_RS27010	COG2205	protein histidine kinase activity
GR130_RS27070	COG1136	(ABC) transporter
GR130_RS27105	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GR130_RS27125	COG1231	oxidoreductase activity
GR130_RS27130	COG3961	Belongs to the TPP enzyme family
GR130_RS27210	COG1113	amino acid transport
GR130_RS27220	COG4213	ABC transporter substrate-binding protein
GR130_RS27230	COG4214	carbohydrate transport
GR130_RS27275	COG2132	Multicopper oxidase
GR130_RS27300	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GR130_RS27340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS27355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GR130_RS27415	COG0626	cystathionine gamma-synthase activity
GR130_RS27430	COG0151	Belongs to the GarS family
GR130_RS27445	COG3903	Transcriptional regulator
GR130_RS27445	COG3629	intracellular signal transduction
GR130_RS27465	COG1285	pathogenesis
GR130_RS27495	COG0019	diaminopimelate decarboxylase activity
GR130_RS27515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GR130_RS27520	COG2186	Transcriptional regulator
GR130_RS27545	COG3158	transport of potassium into the cell
GR130_RS27600	COG2409	Drug exporters of the RND superfamily
GR130_RS27605	COG4325	translation initiation factor activity
GR130_RS27665	COG3415	Transposase
GR130_RS27665	COG2801	Transposase and inactivated derivatives
GR130_RS27690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GR130_RS27740	COG0431	NADPH-dependent FMN reductase
GR130_RS27745	COG2223	nitrite transmembrane transporter activity
GR130_RS27750	COG0243	molybdopterin cofactor binding
GR130_RS27755	COG0446	pyridine nucleotide-disulphide oxidoreductase
GR130_RS27760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GR130_RS27760	COG2146	nitrite reductase [NAD(P)H] activity
GR130_RS27770	COG2223	nitrite transmembrane transporter activity
GR130_RS27775	COG2207	Transcriptional regulator
GR130_RS27820	COG3209	COG3209 Rhs family protein
GR130_RS27900	COG3293	Transposase
GR130_RS27920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GR130_RS27935	COG4325	translation initiation factor activity
GR130_RS27940	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS27950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR130_RS27960	COG0287	Prephenate dehydrogenase
GR130_RS27960	COG1605	Chorismate mutase
GR130_RS27970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GR130_RS27995	COG0583	DNA-binding transcription factor activity
GR130_RS28005	COG0656	L-ascorbic acid biosynthetic process
GR130_RS28015	COG4106	trans-aconitate 2-methyltransferase activity
GR130_RS28030	COG2154	pterin-4-alpha-carbinolamine dehydratase
GR130_RS28045	COG0531	amino acid
GR130_RS28095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GR130_RS28110	COG2124	cytochrome p450
GR130_RS28135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR130_RS28140	COG2362	D-Aminopeptidase
GR130_RS28150	COG0366	Alpha amylase catalytic
GR130_RS28180	COG2814	Major facilitator Superfamily
GR130_RS28210	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR130_RS28230	COG2301	Belongs to the HpcH HpaI aldolase family
GR130_RS28240	COG1960	acyl-CoA dehydrogenase activity
GR130_RS28245	COG0688	phosphatidylethanolamine metabolic process
GR130_RS28255	COG1929	Belongs to the glycerate kinase type-1 family
GR130_RS28260	COG0789	Transcriptional regulator
GR130_RS28265	COG0494	nUDIX hydrolase
GR130_RS28345	COG0483	inositol monophosphate 1-phosphatase activity
GR130_RS28355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GR130_RS28365	COG0095	Lipoate-protein ligase
GR130_RS28380	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS28385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS28395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR130_RS28410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GR130_RS28415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR130_RS28430	COG0477	Major facilitator Superfamily
GR130_RS28435	COG1335	isochorismatase
GR130_RS28450	COG0387	Pfam Sodium calcium exchanger
GR130_RS28455	COG0531	amino acid
GR130_RS28465	COG2409	Drug exporters of the RND superfamily
GR130_RS28475	COG0435	Glutathione S-transferase
GR130_RS28480	COG3708	Transcriptional regulator
GR130_RS28480	COG2207	Transcriptional regulator
GR130_RS28485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS28490	COG0596	Alpha beta hydrolase
GR130_RS28495	COG1959	2 iron, 2 sulfur cluster binding
GR130_RS28500	COG1017	nitric oxide dioxygenase activity
GR130_RS28500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GR130_RS28505	COG2226	methyltransferase
GR130_RS28525	COG0765	amino acid transport
GR130_RS28530	COG0765	amino acid transport
GR130_RS28535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR130_RS28540	COG1126	abc transporter atp-binding protein
GR130_RS28560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR130_RS28570	COG1940	carbohydrate kinase activity
GR130_RS28580	COG1172	Belongs to the binding-protein-dependent transport system permease family
GR130_RS28600	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS28610	COG0583	DNA-binding transcription factor activity
GR130_RS28625	COG0800	Aldolase
GR130_RS28660	COG4266	Belongs to the allantoicase family
GR130_RS28665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GR130_RS28670	COG1953	Uracil, thiamine, allantoin
GR130_RS28680	COG1414	Transcriptional regulator
GR130_RS28730	COG2233	PERMEase
GR130_RS28740	COG2233	PERMEase
GR130_RS28750	COG2351	hydroxyisourate hydrolase activity
GR130_RS28770	COG3622	Belongs to the hyi family
GR130_RS28775	COG2084	Dehydrogenase
GR130_RS28780	COG0028	Belongs to the TPP enzyme family
GR130_RS28785	COG0753	catalase activity
GR130_RS28795	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS28800	COG2249	NAD(P)H dehydrogenase (quinone) activity
GR130_RS28810	COG2315	Protein conserved in bacteria
GR130_RS28825	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS28830	COG3415	Transposase
GR130_RS28830	COG2801	Transposase and inactivated derivatives
GR130_RS28835	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS28845	COG0583	DNA-binding transcription factor activity
GR130_RS28880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR130_RS28910	COG1802	Transcriptional regulator
GR130_RS28935	COG0028	Belongs to the TPP enzyme family
GR130_RS28955	COG1162	GTPase activity
GR130_RS29010	COG0789	Transcriptional regulator
GR130_RS29035	COG0745	RESPONSE REGULATOR receiver
GR130_RS29040	COG0640	Transcriptional regulator
GR130_RS29050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GR130_RS29055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR130_RS29055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GR130_RS29060	COG3290	protein histidine kinase activity
GR130_RS29085	COG2755	lipolytic protein G-D-S-L family
GR130_RS29085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GR130_RS29090	COG1215	transferase activity, transferring glycosyl groups
GR130_RS29105	COG0842	Transport permease protein
GR130_RS29105	COG1716	ATPase activity
GR130_RS29105	COG1131	(ABC) transporter
GR130_RS29135	COG3794	PFAM blue (type 1) copper domain protein
GR130_RS29145	COG0667	Aldo Keto reductase
GR130_RS29150	COG3511	phospholipase C
GR130_RS29160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GR130_RS29180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GR130_RS29185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GR130_RS29190	COG2080	2 iron, 2 sulfur cluster binding
GR130_RS29260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GR130_RS29265	COG3485	protocatechuate 3,4-dioxygenase
GR130_RS29270	COG3485	protocatechuate 3,4-dioxygenase
GR130_RS29275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GR130_RS29285	COG1414	Transcriptional regulator
GR130_RS29295	COG1960	acyl-CoA dehydrogenase activity
GR130_RS29325	COG0175	sulfate reduction
GR130_RS29350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GR130_RS29355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GR130_RS29390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GR130_RS29400	COG2409	Drug exporters of the RND superfamily
GR130_RS29420	COG2205	protein histidine kinase activity
GR130_RS29425	COG0745	RESPONSE REGULATOR receiver
GR130_RS29440	COG4585	Histidine kinase
GR130_RS29445	COG2197	response regulator
GR130_RS29535	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS29555	COG0154	amidase activity
GR130_RS29575	COG2197	response regulator
GR130_RS29580	COG4585	Histidine kinase
GR130_RS29615	COG1131	(ABC) transporter
GR130_RS29635	COG1215	transferase activity, transferring glycosyl groups
GR130_RS29655	COG5002	protein histidine kinase activity
GR130_RS29655	COG2176	DNA-directed DNA polymerase activity
GR130_RS29680	COG0583	DNA-binding transcription factor activity
GR130_RS29685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GR130_RS29720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GR130_RS29725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GR130_RS29730	COG2197	response regulator
GR130_RS29735	COG4585	Histidine kinase
GR130_RS29745	COG0577	efflux transmembrane transporter activity
GR130_RS29745	COG1136	(ABC) transporter
GR130_RS29790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS29820	COG0183	Belongs to the thiolase family
GR130_RS29830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GR130_RS29845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GR130_RS29855	COG1024	Enoyl-CoA hydratase
GR130_RS29855	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR130_RS29865	COG0531	amino acid
GR130_RS29870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GR130_RS29875	COG4214	carbohydrate transport
GR130_RS29885	COG4213	ABC transporter substrate-binding protein
GR130_RS29890	COG1940	carbohydrate kinase activity
GR130_RS29900	COG1175	transmembrane transport
GR130_RS29915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GR130_RS29920	COG2197	response regulator
GR130_RS29935	COG3795	YCII-related domain
GR130_RS29945	COG1595	DNA-templated transcription, initiation
GR130_RS29965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GR130_RS29990	COG2814	Major facilitator Superfamily
GR130_RS30025	COG0546	phosphoglycolate phosphatase activity
GR130_RS30055	COG1024	Enoyl-CoA hydratase
GR130_RS30065	COG0531	amino acid
GR130_RS30070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GR130_RS30085	COG4977	sequence-specific DNA binding
GR130_RS30090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GR130_RS30120	COG1799	cell septum assembly
GR130_RS30160	COG3424	synthase
GR130_RS30165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GR130_RS30170	COG0531	amino acid
GR130_RS30180	COG0569	domain protein
GR130_RS30220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GR130_RS30225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GR130_RS30230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GR130_RS30245	COG0756	dUTP diphosphatase activity
GR130_RS30270	COG2205	protein histidine kinase activity
GR130_RS30275	COG0745	RESPONSE REGULATOR receiver
GR130_RS30280	COG0483	inositol monophosphate 1-phosphatase activity
GR130_RS30320	COG1435	thymidine kinase activity
GR130_RS30355	COG1435	thymidine kinase activity
GR130_RS30360	COG3291	Pkd domain containing protein
GR130_RS30360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GR130_RS30380	COG2197	response regulator
GR130_RS30485	COG2814	Major facilitator Superfamily
GR130_RS30515	COG1435	thymidine kinase activity
GR130_RS30530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GR130_RS30530	COG0045	succinate-CoA ligase (ADP-forming) activity
GR130_RS30530	COG1042	CoA-binding domain protein
GR130_RS30535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GR130_RS30540	COG1802	Transcriptional regulator
GR130_RS30545	COG0739	heme binding
GR130_RS30555	COG0612	Peptidase, M16
GR130_RS30560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GR130_RS30575	COG2197	response regulator
GR130_RS30580	COG4585	Histidine kinase
GR130_RS30590	COG0187	DNA topoisomerase II activity
GR130_RS30605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GR130_RS30610	COG2186	Transcriptional regulator
GR130_RS30615	COG0494	nUDIX hydrolase
GR130_RS30645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GR130_RS30655	COG0588	phosphoglycerate mutase activity
GR130_RS30660	COG0488	(ABC) transporter
GR130_RS30690	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GR130_RS30695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GR130_RS30700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GR130_RS30705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GR130_RS30740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GR130_RS30750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GR130_RS30755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GR130_RS30765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GR130_RS30780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GR130_RS30790	COG0583	DNA-binding transcription factor activity
GR130_RS30805	COG1278	Cold shock
GR130_RS30810	COG2205	protein histidine kinase activity
GR130_RS30815	COG0745	RESPONSE REGULATOR receiver
GR130_RS30820	COG1126	abc transporter atp-binding protein
GR130_RS30825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GR130_RS30830	COG0765	amino acid transport
GR130_RS30835	COG0765	amino acid transport
GR130_RS30840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS30850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GR130_RS30875	COG0745	RESPONSE REGULATOR receiver
GR130_RS30885	COG1316	TRANSCRIPTIONal
GR130_RS30890	COG0640	Transcriptional regulator
GR130_RS30895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GR130_RS30940	COG1201	RNA secondary structure unwinding
GR130_RS30945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GR130_RS30960	COG1396	sequence-specific DNA binding
GR130_RS30965	COG1058	Belongs to the CinA family
GR130_RS30965	COG1546	Belongs to the CinA family
GR130_RS30975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GR130_RS30985	COG1674	ftsk spoiiie
GR130_RS30995	COG3850	Histidine kinase
GR130_RS30995	COG3437	response regulator, receiver
GR130_RS30995	COG2205	protein histidine kinase activity
GR130_RS30995	COG4999	Histidine kinase
GR130_RS31000	COG2770	Histidine kinase
GR130_RS31000	COG2208	phosphoserine phosphatase activity
GR130_RS31030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GR130_RS31035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GR130_RS31040	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GR130_RS31060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GR130_RS31065	COG0612	Peptidase, M16
GR130_RS31070	COG1185	polyribonucleotide nucleotidyltransferase activity
GR130_RS31075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GR130_RS31085	COG1674	ftsk spoiiie
GR130_RS31160	COG1404	Belongs to the peptidase S8 family
GR130_RS31205	COG0455	bacterial-type flagellum organization
GR130_RS31220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GR130_RS31225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GR130_RS31235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GR130_RS31250	COG0779	Required for maturation of 30S ribosomal subunits
GR130_RS31265	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GR130_RS31270	COG0442	prolyl-tRNA aminoacylation
GR130_RS31285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GR130_RS31290	COG0750	zinc metalloprotease
GR130_RS31295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GR130_RS31305	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS31310	COG2508	Transcriptional regulator
GR130_RS31335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GR130_RS31340	COG1177	transmembrane transport
GR130_RS31345	COG1176	ABC-type spermidine putrescine transport system, permease component I
GR130_RS31350	COG3842	ATPase activity
GR130_RS31360	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS31370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR130_RS31385	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS31395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GR130_RS31400	COG1136	(ABC) transporter
GR130_RS31435	COG4585	Histidine kinase
GR130_RS31440	COG2197	response regulator
GR130_RS31445	COG3842	ATPase activity
GR130_RS31450	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GR130_RS31460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GR130_RS31470	COG0233	cytoplasmic translational termination
GR130_RS31475	COG0528	UMP kinase activity
GR130_RS31480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GR130_RS31485	COG0052	Belongs to the universal ribosomal protein uS2 family
GR130_RS31500	COG1191	sigma factor activity
GR130_RS31515	COG0792	nuclease activity
GR130_RS31525	COG1051	belongs to the nudix hydrolase family
GR130_RS31530	COG0681	Belongs to the peptidase S26 family
GR130_RS31535	COG0681	Belongs to the peptidase S26 family
GR130_RS31540	COG0681	Belongs to the peptidase S26 family
GR130_RS31545	COG0681	Belongs to the peptidase S26 family
GR130_RS31550	COG0335	large ribosomal subunit rRNA binding
GR130_RS31555	COG0336	Belongs to the RNA methyltransferase TrmD family
GR130_RS31560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GR130_RS31565	COG1837	Belongs to the UPF0109 family
GR130_RS31570	COG0228	four-way junction DNA binding
GR130_RS31590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GR130_RS31625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GR130_RS31640	COG0477	Major facilitator Superfamily
GR130_RS31645	COG1196	nuclear chromosome segregation
GR130_RS31655	COG1254	Belongs to the acylphosphatase family
GR130_RS31660	COG2340	Cysteine-rich secretory protein family
GR130_RS31700	COG0546	phosphoglycolate phosphatase activity
GR130_RS31710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GR130_RS31715	COG0571	ribonuclease III activity
GR130_RS31720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GR130_RS31735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GR130_RS31740	COG0742	ribosomal rna small subunit methyltransferase
GR130_RS31750	COG1461	Dihydroxyacetone kinase
GR130_RS31755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GR130_RS31760	COG0351	phosphomethylpyrimidine kinase
GR130_RS31780	COG1181	Belongs to the D-alanine--D-alanine ligase family
GR130_RS31785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GR130_RS31805	COG0776	regulation of translation
GR130_RS31815	COG0066	3-isopropylmalate dehydratase activity
GR130_RS31820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GR130_RS31825	COG1414	Transcriptional regulator
GR130_RS31860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GR130_RS31865	COG0179	Fumarylacetoacetate (FAA) hydrolase
GR130_RS31880	COG2018	Roadblock/LC7 domain
GR130_RS31900	COG2018	Roadblock/LC7 domain
GR130_RS31925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR130_RS31930	COG5492	domain, Protein
GR130_RS31940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GR130_RS31945	COG0477	Major facilitator Superfamily
GR130_RS31950	COG1309	transcriptional regulator
GR130_RS31955	COG2957	Belongs to the agmatine deiminase family
GR130_RS31960	COG0804	urea catabolic process
GR130_RS31965	COG0832	Belongs to the urease beta subunit family
GR130_RS31965	COG0831	urea catabolic process
GR130_RS31975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GR130_RS31980	COG0473	3-isopropylmalate dehydrogenase activity
GR130_RS31985	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS31990	COG0506	proline dehydrogenase activity
GR130_RS31995	COG3835	regulator
GR130_RS32015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GR130_RS32020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GR130_RS32025	COG0440	acetolactate synthase activity
GR130_RS32040	COG5001	Diguanylate cyclase
GR130_RS32040	COG3300	MHYT domain
GR130_RS32050	COG0667	Aldo Keto reductase
GR130_RS32055	COG2133	pyrroloquinoline quinone binding
GR130_RS32060	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GR130_RS32060	COG1672	PFAM Archaeal ATPase
GR130_RS32075	COG2409	Drug exporters of the RND superfamily
GR130_RS32085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GR130_RS32095	COG0154	amidase activity
GR130_RS32100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GR130_RS32110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GR130_RS32140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GR130_RS32150	COG0482	sulfurtransferase activity
GR130_RS32165	COG2161	toxin-antitoxin pair type II binding
GR130_RS32180	COG2860	membrane
GR130_RS32185	COG0308	aminopeptidase N
GR130_RS32190	COG4608	Belongs to the ABC transporter superfamily
GR130_RS32195	COG0444	Belongs to the ABC transporter superfamily
GR130_RS32210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GR130_RS32230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GR130_RS32235	COG0509	glycine decarboxylation via glycine cleavage system
GR130_RS32240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GR130_RS32245	COG1760	l-serine dehydratase
GR130_RS32255	COG0671	phosphoesterase, PA-phosphatase related
GR130_RS32260	COG0671	phosphoesterase, PA-phosphatase related
GR130_RS32265	COG0586	Pfam SNARE associated Golgi protein
GR130_RS32285	COG0745	RESPONSE REGULATOR receiver
GR130_RS32300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GR130_RS32310	COG0785	Cytochrome C biogenesis protein
GR130_RS32315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GR130_RS32315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GR130_RS32350	COG1132	(ABC) transporter
GR130_RS32355	COG1132	(ABC) transporter
GR130_RS32370	COG0366	Alpha amylase catalytic
GR130_RS32375	COG0366	Alpha amylase catalytic
GR130_RS32385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GR130_RS32390	COG1301	dicarboxylic acid transport
GR130_RS32395	COG3290	protein histidine kinase activity
GR130_RS32400	COG4565	transcriptional regulatory protein
GR130_RS32415	COG0395	ABC-type sugar transport system, permease component
GR130_RS32425	COG1136	(ABC) transporter
GR130_RS32425	COG0577	efflux transmembrane transporter activity
GR130_RS32430	COG0577	efflux transmembrane transporter activity
GR130_RS32435	COG0205	6-phosphofructokinase activity
GR130_RS32440	COG0857	belongs to the CobB CobQ family
GR130_RS32440	COG0280	phosphate acetyltransferase
GR130_RS32445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GR130_RS32485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GR130_RS32490	COG0745	RESPONSE REGULATOR receiver
GR130_RS32495	COG2205	protein histidine kinase activity
GR130_RS32550	COG0183	Belongs to the thiolase family
GR130_RS32605	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GR130_RS32620	COG1250	3-hydroxyacyl-CoA dehydrogenase
GR130_RS32640	COG4585	Histidine kinase
GR130_RS32645	COG2197	response regulator
GR130_RS32655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GR130_RS32660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GR130_RS32665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GR130_RS32670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GR130_RS32675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GR130_RS32680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GR130_RS32685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GR130_RS32705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GR130_RS32710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GR130_RS32720	COG2890	protein-(glutamine-N5) methyltransferase activity
GR130_RS32725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GR130_RS32730	COG0254	rRNA binding
GR130_RS32745	COG0083	homoserine kinase activity
GR130_RS32750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GR130_RS32755	COG0460	homoserine dehydrogenase
GR130_RS32760	COG0019	diaminopimelate decarboxylase activity
GR130_RS32765	COG0018	arginyl-trna synthetase
GR130_RS32810	COG2197	response regulator
GR130_RS32815	COG2124	cytochrome p450
GR130_RS32825	COG0768	penicillin binding
GR130_RS32835	COG1119	ATPase activity
GR130_RS32840	COG0596	Alpha beta hydrolase
GR130_RS32885	COG5002	protein histidine kinase activity
GR130_RS32905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GR130_RS32910	COG1357	PFAM Pentapeptide repeats (8 copies)
GR130_RS32925	COG0745	RESPONSE REGULATOR receiver
GR130_RS32930	COG2205	protein histidine kinase activity
GR130_RS32935	COG0508	dehydrogenase complex catalyzes the overall conversion of
GR130_RS32935	COG0567	Dehydrogenase, E1 component
GR130_RS32960	COG2329	Antibiotic biosynthesis monooxygenase
GR130_RS32970	COG0604	alcohol dehydrogenase
GR130_RS32975	COG0281	malic enzyme
GR130_RS32985	COG0765	amino acid transport
GR130_RS32990	COG1126	abc transporter atp-binding protein
GR130_RS32995	COG4106	trans-aconitate 2-methyltransferase activity
GR130_RS33030	COG3795	YCII-related domain
GR130_RS33035	COG4941	Belongs to the sigma-70 factor family
GR130_RS33050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GR130_RS33055	COG1993	acr, cog1993
GR130_RS33060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GR130_RS33065	COG2186	Transcriptional regulator
GR130_RS33070	COG2807	transmembrane transport
GR130_RS33075	COG0598	Magnesium transport protein CorA
GR130_RS33080	COG0477	Major facilitator Superfamily
GR130_RS33100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GR130_RS33110	COG2066	Belongs to the glutaminase family
GR130_RS33120	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GR130_RS33135	COG0456	acetyltransferase
GR130_RS33155	COG1597	lipid kinase activity
GR130_RS33170	COG1309	transcriptional regulator
GR130_RS33175	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS33180	COG0363	glucosamine-6-phosphate deaminase activity
GR130_RS33185	COG1472	Belongs to the glycosyl hydrolase 3 family
GR130_RS33205	COG2188	Transcriptional regulator
GR130_RS33230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GR130_RS33235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GR130_RS33240	COG0242	peptide deformylase activity
GR130_RS33260	COG5662	AntiSigma factor
GR130_RS33265	COG1595	DNA-templated transcription, initiation
GR130_RS33275	COG2135	peptidase activity
GR130_RS33285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GR130_RS33295	COG2076	Multidrug Resistance protein
GR130_RS33305	COG0483	inositol monophosphate 1-phosphatase activity
GR130_RS33310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GR130_RS33310	COG0517	IMP dehydrogenase activity
GR130_RS33315	COG0753	catalase activity
GR130_RS33340	COG1615	UPF0182 protein
GR130_RS33350	COG3480	Lon protease (S16) C-terminal proteolytic domain
GR130_RS33395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GR130_RS33435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR130_RS33440	COG0210	DNA helicase
GR130_RS33445	COG0210	DNA helicase
GR130_RS33530	COG1432	Conserved Protein
GR130_RS33535	COG2095	MarC family integral membrane protein
GR130_RS33555	COG0598	Magnesium transport protein CorA
GR130_RS33590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GR130_RS33595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GR130_RS33605	COG1595	DNA-templated transcription, initiation
GR130_RS33620	COG1024	Enoyl-CoA hydratase
GR130_RS33625	COG0519	Catalyzes the synthesis of GMP from XMP
GR130_RS33635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GR130_RS33640	COG1611	Belongs to the LOG family
GR130_RS33645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GR130_RS33685	COG2197	response regulator
GR130_RS33690	COG4585	Histidine kinase
GR130_RS33700	COG1131	(ABC) transporter
GR130_RS33715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GR130_RS33740	COG0747	negative chemotaxis
GR130_RS33745	COG0601	transmembrane transport
GR130_RS33750	COG0444	Belongs to the ABC transporter superfamily
GR130_RS33755	COG4608	Belongs to the ABC transporter superfamily
GR130_RS33760	COG4608	Belongs to the ABC transporter superfamily
GR130_RS33765	COG0444	Belongs to the ABC transporter superfamily
GR130_RS33775	COG0601	transmembrane transport
GR130_RS33780	COG4166	transmembrane transport
GR130_RS33805	COG1053	succinate dehydrogenase
GR130_RS33815	COG0402	S-adenosylhomocysteine deaminase activity
GR130_RS33840	COG0531	amino acid
GR130_RS33850	COG1473	amidohydrolase
GR130_RS33880	COG3903	Transcriptional regulator
GR130_RS33880	COG3629	intracellular signal transduction
GR130_RS33900	COG2197	response regulator
GR130_RS33965	COG0515	serine threonine protein kinase
GR130_RS34000	COG0582	viral genome integration into host DNA
GR130_RS34010	COG0012	GTP binding
GR130_RS34025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GR130_RS34030	COG1113	amino acid transport
GR130_RS34035	COG1570	exodeoxyribonuclease VII activity
GR130_RS34040	COG1722	exodeoxyribonuclease VII activity
GR130_RS34045	COG0778	Nitroreductase
GR130_RS34070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GR130_RS34070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GR130_RS34090	COG0114	fumarate hydratase activity
GR130_RS34100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GR130_RS34115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GR130_RS34130	COG1136	(ABC) transporter
GR130_RS34145	COG1136	(ABC) transporter
GR130_RS34170	COG0450	alkyl hydroperoxide reductase
GR130_RS34175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR130_RS34190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GR130_RS34195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GR130_RS34200	COG0667	Aldo Keto reductase
GR130_RS34215	COG2885	chlorophyll binding
GR130_RS34280	COG2610	gluconate transmembrane transporter activity
GR130_RS34285	COG0251	oxidation-reduction process
GR130_RS34290	COG1414	Transcriptional regulator
GR130_RS34305	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GR130_RS34320	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GR130_RS34335	COG0789	Transcriptional regulator
GR130_RS34340	COG0154	amidase activity
GR130_RS34345	COG2130	NADP-dependent
GR130_RS34350	COG1331	Highly conserved protein containing a thioredoxin domain
GR130_RS34365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GR130_RS34375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GR130_RS34390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GR130_RS34420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GR130_RS34435	COG1476	TRANSCRIPTIONal
GR130_RS34495	COG1376	ErfK ybiS ycfS ynhG family protein
GR130_RS34510	COG2986	histidine ammonia-lyase
GR130_RS34520	COG1024	Enoyl-CoA hydratase
GR130_RS34525	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GR130_RS34535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR130_RS34550	COG0768	penicillin binding
GR130_RS34555	COG2365	Tyrosine phosphatase family
GR130_RS34565	COG0424	maF-like protein
GR130_RS34580	COG0515	serine threonine protein kinase
GR130_RS34580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GR130_RS34585	COG0515	serine threonine protein kinase
GR130_RS34585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GR130_RS34600	COG4770	biotin carboxylase activity
GR130_RS34635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GR130_RS34655	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS34660	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS34675	COG1595	DNA-templated transcription, initiation
GR130_RS34680	COG0745	RESPONSE REGULATOR receiver
GR130_RS34685	COG2205	protein histidine kinase activity
GR130_RS34710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GR130_RS34720	COG0583	DNA-binding transcription factor activity
GR130_RS34725	COG2814	Major facilitator Superfamily
GR130_RS34780	COG1744	ABC transporter substrate-binding protein PnrA-like
GR130_RS34785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GR130_RS34785	COG1473	amidohydrolase
GR130_RS34795	COG2089	acid synthase
GR130_RS34810	COG1216	Glycosyl transferase, family 2
GR130_RS34820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GR130_RS34840	COG3265	gluconokinase activity
GR130_RS34885	COG2009	succinate dehydrogenase
GR130_RS34895	COG1053	succinate dehydrogenase
GR130_RS34900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GR130_RS34950	COG1295	ribonuclease BN
GR130_RS34960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GR130_RS34985	COG0180	Tryptophanyl-tRNA synthetase
GR130_RS34990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GR130_RS34995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GR130_RS35005	COG0456	acetyltransferase
GR130_RS35010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GR130_RS35015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR130_RS35020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GR130_RS35025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GR130_RS35080	COG4176	ABC-type proline glycine betaine transport system permease component
GR130_RS35085	COG4175	Glycine betaine
GR130_RS35085	COG0517	IMP dehydrogenase activity
GR130_RS35125	COG0039	L-malate dehydrogenase activity
GR130_RS35130	COG0538	isocitrate dehydrogenase activity
GR130_RS35140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GR130_RS35145	COG1714	RDD family
GR130_RS35155	COG0138	bifunctional purine biosynthesis protein purh
GR130_RS35185	COG0045	succinate-CoA ligase (ADP-forming) activity
GR130_RS35300	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GR130_RS35310	COG0714	Associated with various cellular activities
GR130_RS35325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GR130_RS35335	COG0739	heme binding
GR130_RS35365	COG2197	response regulator
GR130_RS35375	COG0515	serine threonine protein kinase
GR130_RS35375	COG2815	serine threonine protein kinase
GR130_RS35425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GR130_RS35425	COG0519	Catalyzes the synthesis of GMP from XMP
GR130_RS35445	COG0515	serine threonine protein kinase
GR130_RS35470	COG4585	Histidine kinase
GR130_RS35520	COG1131	(ABC) transporter
GR130_RS35540	COG0596	Alpha beta hydrolase
GR130_RS35540	COG2945	thiolester hydrolase activity
GR130_RS35550	COG4821	SIS domain
GR130_RS35560	COG0259	pyridoxamine-phosphate oxidase activity
GR130_RS35575	COG1024	Enoyl-CoA hydratase
GR130_RS35580	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS35595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GR130_RS35625	COG5006	permease, DMT superfamily
GR130_RS35630	COG0583	DNA-binding transcription factor activity
GR130_RS35635	COG0247	lactate metabolic process
GR130_RS35635	COG0277	FAD linked oxidase domain protein
GR130_RS35650	COG2378	regulation of single-species biofilm formation
GR130_RS35655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GR130_RS35670	COG0667	Aldo Keto reductase
GR130_RS35695	COG2252	PERMEase
GR130_RS35705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GR130_RS35725	COG2814	Major facilitator Superfamily
GR130_RS35735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GR130_RS35740	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GR130_RS35745	COG1278	Cold shock
GR130_RS35760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR130_RS35765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR130_RS35770	COG1120	ATPase activity
GR130_RS35775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GR130_RS35835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GR130_RS35840	COG1061	Type III restriction enzyme res subunit
GR130_RS35860	COG3142	Participates in the control of copper homeostasis
GR130_RS35905	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GR130_RS35910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GR130_RS35910	COG1263	PTS System
GR130_RS35975	COG0463	Glycosyl transferase, family 2
GR130_RS35980	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GR130_RS36020	COG1105	Belongs to the carbohydrate kinase PfkB family
GR130_RS36045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GR130_RS36100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GR130_RS36135	COG0582	viral genome integration into host DNA
GR130_RS36165	COG3842	ATPase activity
GR130_RS36190	COG0215	cysteine-tRNA ligase activity
GR130_RS36195	COG3467	pyridoxamine 5'-phosphate
GR130_RS36200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GR130_RS36205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GR130_RS36210	COG1329	Transcriptional regulator
GR130_RS36230	COG5002	protein histidine kinase activity
GR130_RS36245	COG0588	phosphoglycerate mutase activity
GR130_RS36265	COG0438	transferase activity, transferring glycosyl groups
GR130_RS36280	COG0667	Aldo Keto reductase
GR130_RS36295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GR130_RS36315	COG0456	acetyltransferase
GR130_RS36350	COG2205	protein histidine kinase activity
GR130_RS36350	COG2972	Histidine kinase
GR130_RS36355	COG0745	RESPONSE REGULATOR receiver
GR130_RS36365	COG1609	Transcriptional regulator
GR130_RS36370	COG0745	RESPONSE REGULATOR receiver
GR130_RS36405	COG2897	thiosulfate sulfurtransferase activity
GR130_RS36425	COG3485	protocatechuate 3,4-dioxygenase
GR130_RS36430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR130_RS36435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GR130_RS36455	COG1490	D-aminoacyl-tRNA deacylase activity
GR130_RS36475	COG0431	NADPH-dependent FMN reductase
GR130_RS36510	COG0667	Aldo Keto reductase
GR130_RS36525	COG2890	protein-(glutamine-N5) methyltransferase activity
GR130_RS36570	COG0791	NLP P60 protein
GR130_RS36595	COG0306	phosphate transporter
GR130_RS36605	COG1937	Protein conserved in bacteria
GR130_RS36625	COG0277	FAD linked oxidase domain protein
GR130_RS36630	COG0671	phosphoesterase, PA-phosphatase related
GR130_RS36635	COG0739	heme binding
GR130_RS36635	COG1196	nuclear chromosome segregation
GR130_RS36635	COG0741	lytic transglycosylase activity
GR130_RS36680	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS36695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS36705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GR130_RS36710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GR130_RS36765	COG0180	Tryptophanyl-tRNA synthetase
GR130_RS36770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GR130_RS36775	COG0842	Transport permease protein
GR130_RS36775	COG1129	ABC transporter
GR130_RS36785	COG1595	DNA-templated transcription, initiation
GR130_RS36800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GR130_RS36800	COG0515	serine threonine protein kinase
GR130_RS36850	COG0129	dihydroxy-acid dehydratase activity
GR130_RS36860	COG1082	Xylose isomerase domain protein TIM barrel
GR130_RS36865	COG0248	Ppx GppA phosphatase
GR130_RS36885	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GR130_RS36905	COG1194	a g-specific adenine glycosylase
GR130_RS36910	COG1595	DNA-templated transcription, initiation
GR130_RS36925	COG0745	RESPONSE REGULATOR receiver
GR130_RS36930	COG2205	protein histidine kinase activity
GR130_RS36970	COG0739	heme binding
GR130_RS36980	COG0542	response to heat
GR130_RS36990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GR130_RS37010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GR130_RS37020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GR130_RS37025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GR130_RS37045	COG0640	Transcriptional regulator
GR130_RS37055	COG4585	Histidine kinase
GR130_RS37065	COG0649	NAD binding
GR130_RS37075	COG1732	Glycine betaine
GR130_RS37085	COG1174	glycine betaine transport
GR130_RS37090	COG0517	IMP dehydrogenase activity
GR130_RS37090	COG1125	glycine betaine transport
GR130_RS37100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GR130_RS37105	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GR130_RS37120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GR130_RS37120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GR130_RS37130	COG0302	gtp cyclohydrolase
GR130_RS37145	COG0037	tRNA processing
GR130_RS37160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GR130_RS37195	COG1132	(ABC) transporter
GR130_RS37205	COG0586	Pfam SNARE associated Golgi protein
GR130_RS37210	COG0393	Putative heavy-metal-binding
GR130_RS37215	COG0789	Transcriptional regulator
GR130_RS37225	COG0655	NAD(P)H dehydrogenase (quinone) activity
GR130_RS37230	COG0076	glutamate decarboxylase activity
GR130_RS37240	COG2318	DinB family
GR130_RS37245	COG1012	belongs to the aldehyde dehydrogenase family
GR130_RS37270	COG0640	Transcriptional regulator
GR130_RS37275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GR130_RS37285	COG0254	rRNA binding
GR130_RS37290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GR130_RS37295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GR130_RS37300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GR130_RS37310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GR130_RS37310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GR130_RS37340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GR130_RS37340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GR130_RS37350	COG1309	transcriptional regulator
GR130_RS37375	COG3594	Acyltransferase
GR130_RS37385	COG0584	glycerophosphoryl diester phosphodiesterase
GR130_RS37400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GR130_RS37405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GR130_RS37410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GR130_RS37410	COG1754	DNA topoisomerase type I activity
GR130_RS37435	COG2890	protein-(glutamine-N5) methyltransferase activity
GR130_RS37445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GR130_RS37460	COG1366	Belongs to the anti-sigma-factor antagonist family
GR130_RS37465	COG1205	dead DEAH box helicase
GR130_RS37465	COG1111	helicase
GR130_RS37525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GR130_RS37530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GR130_RS37540	COG2267	carboxylic ester hydrolase activity
GR130_RS37570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GR130_RS37595	COG0003	Pfam Anion-transporting ATPase
GR130_RS37610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GR130_RS37615	COG1610	YqeY-like protein
GR130_RS37620	COG1408	metallophosphoesterase
GR130_RS37635	COG1609	Transcriptional regulator
GR130_RS37695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GR130_RS37700	COG0737	Belongs to the 5'-nucleotidase family
GR130_RS37715	COG0297	glycogen (starch) synthase activity
GR130_RS37735	COG0477	Major facilitator Superfamily
GR130_RS37745	COG0673	inositol 2-dehydrogenase activity
GR130_RS37780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GR130_RS37850	COG0367	asparagine synthase
GR130_RS37860	COG1120	ATPase activity
GR130_RS37865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GR130_RS37895	COG0339	signal peptide processing
GR130_RS37925	COG1595	DNA-templated transcription, initiation
GR130_RS37945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GR130_RS37950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GR130_RS37975	COG0745	RESPONSE REGULATOR receiver
GR130_RS37985	COG2188	Transcriptional regulator
GR130_RS37995	COG4249	Peptidase C14 caspase catalytic subunit p20
GR130_RS37995	COG2319	Wd-40 repeat
GR130_RS38020	COG3290	protein histidine kinase activity
GR130_RS38025	COG1132	(ABC) transporter
GR130_RS38035	COG1113	amino acid transport
GR130_RS38075	COG1834	amidinotransferase
GR130_RS38080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GR130_RS38155	COG0477	Major facilitator Superfamily
GR130_RS38175	COG2268	Band 7 protein
GR130_RS38205	COG1064	alcohol dehydrogenase
GR130_RS38245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GR130_RS38255	COG0590	tRNA wobble adenosine to inosine editing
GR130_RS38265	COG0582	viral genome integration into host DNA
GR130_RS38280	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS38435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GR130_RS38440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GR130_RS38605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GR130_RS38610	COG2801	Transposase and inactivated derivatives
GR130_RS38620	COG1309	transcriptional regulator
GR130_RS38630	COG3328	transposase activity
GR130_RS38640	COG0640	Transcriptional regulator
GR130_RS38650	COG0745	RESPONSE REGULATOR receiver
GR130_RS38675	COG0640	Transcriptional regulator
GR130_RS38685	COG1285	pathogenesis
GR130_RS38710	COG1191	sigma factor activity
GR130_RS38715	COG1191	sigma factor activity
GR130_RS38735	COG1846	Transcriptional regulator
GR130_RS38790	COG0477	Major facilitator Superfamily
GR130_RS38795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GR130_RS38795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GR130_RS38795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GR130_RS38805	COG2205	protein histidine kinase activity
GR130_RS38810	COG0745	RESPONSE REGULATOR receiver
GR130_RS38815	COG3976	FMN-binding domain protein
GR130_RS38815	COG0431	NADPH-dependent FMN reductase
GR130_RS38815	COG1053	succinate dehydrogenase
GR130_RS38835	COG2249	NAD(P)H dehydrogenase (quinone) activity
GR130_RS38895	COG5000	phosphorelay sensor kinase activity
GR130_RS38900	COG0318	PFAM AMP-dependent synthetase and ligase
GR130_RS38915	COG3437	response regulator, receiver
GR130_RS38920	COG1595	DNA-templated transcription, initiation
GR130_RS38970	COG1131	(ABC) transporter
GR130_RS38985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GR130_RS39005	COG0653	protein targeting
GR130_RS39025	COG0006	proline dipeptidase activity
GR130_RS39035	COG1028	Short-chain dehydrogenase reductase Sdr
GR130_RS39080	COG2372	response to copper ion
GR130_RS39085	COG2837	iron assimilation
GR130_RS39090	COG0077	Prephenate dehydratase
GR130_RS39095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GR130_RS39100	COG0561	phosphatase activity
GR130_RS39135	COG2186	Transcriptional regulator
GR130_RS39140	COG2807	transmembrane transport
GR130_RS39185	COG0789	Transcriptional regulator
GR130_RS39190	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GR130_RS39205	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GR130_RS39225	COG0561	phosphatase activity
GR130_RS39235	COG4988	ABC transporter
GR130_RS39240	COG1294	oxidase, subunit
GR130_RS39245	COG1271	oxidase subunit
GR130_RS39255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GR130_RS39260	COG1609	Transcriptional regulator
GR130_RS39265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GR130_RS39280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GR130_RS39305	COG0662	Cupin 2, conserved barrel domain protein
GR130_RS39310	COG1950	PFAM Membrane protein of
GR130_RS39315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GR130_RS39320	COG0626	cystathionine gamma-synthase activity
GR130_RS39355	COG2814	Major facilitator Superfamily
GR130_RS39390	COG4978	Transcriptional regulator
GR130_RS39390	COG0789	Transcriptional regulator
GR130_RS39420	COG0305	Participates in initiation and elongation during chromosome replication
GR130_RS39435	COG0359	binds to the 23S rRNA
GR130_RS39440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GR130_RS39445	COG0629	single-stranded DNA binding
GR130_RS39450	COG0360	Binds together with S18 to 16S ribosomal RNA
GR130_RS39475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GR130_RS39485	COG1260	myo-inositol-1-phosphate synthase
GR130_RS39515	COG2815	serine threonine protein kinase
GR130_RS39515	COG0515	serine threonine protein kinase
GR130_RS39520	COG1595	DNA-templated transcription, initiation
GR130_RS39535	COG3118	belongs to the thioredoxin family
GR130_RS39550	COG1192	Involved in chromosome partitioning
GR130_RS39555	COG0357	Ribosomal RNA small subunit methyltransferase G
GR130_RS39565	COG0706	membrane insertase activity
GR130_RS39570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GR130_RS39575	COG0594	ribonuclease P activity
GR130_RS39580	COG0230	Belongs to the bacterial ribosomal protein bL34 family