locus-tag	class	description
F9278_RS00145	COG0039	L-malate dehydrogenase activity
F9278_RS00340	COG3328	transposase activity
F9278_RS00450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F9278_RS00455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F9278_RS00480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F9278_RS00485	COG3170	Tfp pilus assembly protein FimV
F9278_RS00510	COG2133	pyrroloquinoline quinone binding
F9278_RS00520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F9278_RS00565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F9278_RS00570	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS00580	COG1414	Transcriptional regulator
F9278_RS00650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F9278_RS00665	COG0431	NADPH-dependent FMN reductase
F9278_RS00680	COG1136	(ABC) transporter
F9278_RS00680	COG0577	efflux transmembrane transporter activity
F9278_RS00685	COG1136	(ABC) transporter
F9278_RS00750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F9278_RS00775	COG1595	DNA-templated transcription, initiation
F9278_RS00805	COG2226	methyltransferase
F9278_RS00825	COG3033	Beta-eliminating lyase
F9278_RS00835	COG4249	Peptidase C14 caspase catalytic subunit p20
F9278_RS00835	COG2319	Wd-40 repeat
F9278_RS00845	COG2197	response regulator
F9278_RS00850	COG0730	response to heat
F9278_RS00875	COG1053	succinate dehydrogenase
F9278_RS00875	COG3976	FMN-binding domain protein
F9278_RS00920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F9278_RS00950	COG0784	Response regulator, receiver
F9278_RS00950	COG2205	protein histidine kinase activity
F9278_RS00950	COG5002	protein histidine kinase activity
F9278_RS00955	COG3795	YCII-related domain
F9278_RS00960	COG4941	Belongs to the sigma-70 factor family
F9278_RS00965	COG0309	Hydrogenase expression formation protein (HypE)
F9278_RS00975	COG0298	carbon dioxide binding
F9278_RS00985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F9278_RS00990	COG0375	protein maturation
F9278_RS01030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F9278_RS01030	COG1024	Enoyl-CoA hydratase
F9278_RS01075	COG0725	ABC transporter, periplasmic molybdate-binding protein
F9278_RS01140	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS01170	COG0747	negative chemotaxis
F9278_RS01180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS01185	COG4172	Belongs to the ABC transporter superfamily
F9278_RS01195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS01215	COG3507	Belongs to the glycosyl hydrolase 43 family
F9278_RS01220	COG1609	Transcriptional regulator
F9278_RS01235	COG0346	lactoylglutathione lyase activity
F9278_RS01240	COG0640	Transcriptional regulator
F9278_RS01255	COG0590	tRNA wobble adenosine to inosine editing
F9278_RS01270	COG1687	branched-chain amino acid
F9278_RS01275	COG1959	2 iron, 2 sulfur cluster binding
F9278_RS01280	COG1017	nitric oxide dioxygenase activity
F9278_RS01280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F9278_RS01305	COG1764	response to oxidative stress
F9278_RS01310	COG1053	succinate dehydrogenase
F9278_RS01320	COG2353	YceI-like domain
F9278_RS01330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F9278_RS01335	COG1672	PFAM Archaeal ATPase
F9278_RS01335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F9278_RS01350	COG1819	glycosyl
F9278_RS01365	COG1595	DNA-templated transcription, initiation
F9278_RS01370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F9278_RS01390	COG1595	DNA-templated transcription, initiation
F9278_RS01410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F9278_RS01415	COG2130	NADP-dependent
F9278_RS01425	COG3842	ATPase activity
F9278_RS01430	COG1175	transmembrane transport
F9278_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS01440	COG1960	acyl-CoA dehydrogenase activity
F9278_RS01455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F9278_RS01460	COG1021	2,3-dihydroxybenzoate-AMP ligase
F9278_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS01500	COG1960	acyl-CoA dehydrogenase activity
F9278_RS01510	COG1960	acyl-CoA dehydrogenase activity
F9278_RS01525	COG1024	Enoyl-CoA hydratase
F9278_RS01530	COG1960	acyl-CoA dehydrogenase activity
F9278_RS01535	COG4221	oxidoreductase activity
F9278_RS01575	COG2197	response regulator
F9278_RS01580	COG1960	acyl-CoA dehydrogenase activity
F9278_RS01595	COG2070	2-Nitropropane dioxygenase
F9278_RS01595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F9278_RS01600	COG3321	synthase
F9278_RS01600	COG0604	alcohol dehydrogenase
F9278_RS01615	COG2197	response regulator
F9278_RS01630	COG2197	response regulator
F9278_RS01635	COG3851	Histidine kinase
F9278_RS01665	COG1131	(ABC) transporter
F9278_RS01675	COG4585	Histidine kinase
F9278_RS01680	COG2197	response regulator
F9278_RS01695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F9278_RS01700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F9278_RS01715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F9278_RS01720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F9278_RS01745	COG1191	sigma factor activity
F9278_RS01810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F9278_RS01820	COG1846	Transcriptional regulator
F9278_RS01830	COG0667	Aldo Keto reductase
F9278_RS01835	COG0477	Major facilitator Superfamily
F9278_RS01880	COG0328	RNA-DNA hybrid ribonuclease activity
F9278_RS01915	COG0740	serine-type endopeptidase activity
F9278_RS01920	COG0740	serine-type endopeptidase activity
F9278_RS01930	COG2318	DinB family
F9278_RS01960	COG1120	ATPase activity
F9278_RS01965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS01970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS01975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F9278_RS01980	COG1132	(ABC) transporter
F9278_RS02015	COG0698	ribose 5-phosphate isomerase
F9278_RS02030	COG1716	ATPase activity
F9278_RS02030	COG1131	(ABC) transporter
F9278_RS02030	COG0842	Transport permease protein
F9278_RS02040	COG0667	Aldo Keto reductase
F9278_RS02045	COG0583	DNA-binding transcription factor activity
F9278_RS02065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F9278_RS02070	COG0346	lactoylglutathione lyase activity
F9278_RS02080	COG0667	Aldo Keto reductase
F9278_RS02095	COG2045	Belongs to the ComB family
F9278_RS02100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS02165	COG0456	acetyltransferase
F9278_RS02165	COG0454	-acetyltransferase
F9278_RS02180	COG3594	Acyltransferase
F9278_RS02210	COG4191	Histidine kinase
F9278_RS02265	COG1024	Enoyl-CoA hydratase
F9278_RS02280	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS02285	COG2366	antibiotic biosynthetic process
F9278_RS02300	COG2070	2-Nitropropane dioxygenase
F9278_RS02310	COG0515	serine threonine protein kinase
F9278_RS02330	COG0747	negative chemotaxis
F9278_RS02335	COG0601	transmembrane transport
F9278_RS02340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS02350	COG1960	acyl-CoA dehydrogenase activity
F9278_RS02370	COG0019	diaminopimelate decarboxylase activity
F9278_RS02390	COG1846	Transcriptional regulator
F9278_RS02405	COG0583	DNA-binding transcription factor activity
F9278_RS02410	COG0640	Transcriptional regulator
F9278_RS02455	COG2329	Antibiotic biosynthesis monooxygenase
F9278_RS02460	COG0583	DNA-binding transcription factor activity
F9278_RS02465	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F9278_RS02475	COG0310	cobalt ion transport
F9278_RS02480	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
F9278_RS02490	COG1122	ATPase activity
F9278_RS02495	COG3618	amidohydrolase
F9278_RS02500	COG3254	rhamnose metabolic process
F9278_RS02510	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS02515	COG4948	Mandelate Racemase Muconate Lactonizing
F9278_RS02520	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS02535	COG4214	carbohydrate transport
F9278_RS02540	COG2188	Transcriptional regulator
F9278_RS02585	COG1595	DNA-templated transcription, initiation
F9278_RS02600	COG2197	response regulator
F9278_RS02605	COG4585	Histidine kinase
F9278_RS02630	COG1132	(ABC) transporter
F9278_RS02645	COG0456	acetyltransferase
F9278_RS02660	COG5002	protein histidine kinase activity
F9278_RS02665	COG2018	Roadblock/LC7 domain
F9278_RS02685	COG1408	metallophosphoesterase
F9278_RS02705	COG3321	synthase
F9278_RS02705	COG0604	alcohol dehydrogenase
F9278_RS02710	COG1609	Transcriptional regulator
F9278_RS02735	COG2376	Dihydroxyacetone kinase
F9278_RS02740	COG1461	Dihydroxyacetone kinase
F9278_RS02770	COG1902	pentaerythritol trinitrate reductase activity
F9278_RS02770	COG0446	pyridine nucleotide-disulphide oxidoreductase
F9278_RS02775	COG2890	protein-(glutamine-N5) methyltransferase activity
F9278_RS02790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F9278_RS02810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F9278_RS02815	COG3458	cephalosporin-C deacetylase activity
F9278_RS02825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F9278_RS02830	COG0596	Alpha beta hydrolase
F9278_RS02835	COG2226	methyltransferase
F9278_RS02860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F9278_RS02865	COG1686	Belongs to the peptidase S11 family
F9278_RS02870	COG5650	phosphatidylinositol metabolic process
F9278_RS02880	COG2066	Belongs to the glutaminase family
F9278_RS02900	COG1113	amino acid transport
F9278_RS02910	COG1968	undecaprenyl-diphosphatase activity
F9278_RS02915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F9278_RS02920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F9278_RS02950	COG1175	transmembrane transport
F9278_RS02955	COG0395	ABC-type sugar transport system, permease component
F9278_RS02965	COG0477	Major facilitator Superfamily
F9278_RS02990	COG0366	Alpha amylase catalytic
F9278_RS03000	COG3281	Trehalose synthase
F9278_RS03005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F9278_RS03020	COG0583	DNA-binding transcription factor activity
F9278_RS03035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS03040	COG1116	anion transmembrane transporter activity
F9278_RS03050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS03055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F9278_RS03065	COG0277	FAD linked oxidase domain protein
F9278_RS03075	COG1874	Beta-galactosidase
F9278_RS03075	COG0366	Alpha amylase catalytic
F9278_RS03100	COG3250	beta-galactosidase activity
F9278_RS03110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F9278_RS03140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F9278_RS03145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F9278_RS03155	COG0438	transferase activity, transferring glycosyl groups
F9278_RS03210	COG0714	Associated with various cellular activities
F9278_RS03235	COG1253	flavin adenine dinucleotide binding
F9278_RS03245	COG2197	response regulator
F9278_RS03250	COG4585	Histidine kinase
F9278_RS03255	COG1136	(ABC) transporter
F9278_RS03280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F9278_RS03315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F9278_RS03320	COG1215	transferase activity, transferring glycosyl groups
F9278_RS03345	COG0464	growth
F9278_RS03360	COG1349	DNA-binding transcription factor activity
F9278_RS03385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F9278_RS03410	COG1940	carbohydrate kinase activity
F9278_RS03420	COG2813	Specifically methylates the guanine in position
F9278_RS03435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F9278_RS03440	COG1349	DNA-binding transcription factor activity
F9278_RS03480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS03485	COG0738	Major facilitator superfamily
F9278_RS03510	COG2197	response regulator
F9278_RS03515	COG4585	Histidine kinase
F9278_RS03530	COG0445	tRNA wobble uridine modification
F9278_RS03540	COG1660	Displays ATPase and GTPase activities
F9278_RS03590	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F9278_RS03615	COG0204	Acyl-transferase
F9278_RS03640	COG0584	glycerophosphoryl diester phosphodiesterase
F9278_RS03660	COG0667	Aldo Keto reductase
F9278_RS03665	COG1846	Transcriptional regulator
F9278_RS03685	COG0671	phosphoesterase, PA-phosphatase related
F9278_RS03705	COG0493	'glutamate synthase
F9278_RS03720	COG3509	depolymerase
F9278_RS03745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F9278_RS03810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F9278_RS03815	COG2151	metal-sulfur cluster biosynthetic enzyme
F9278_RS03820	COG3396	Phenylacetate-CoA oxygenase
F9278_RS03825	COG3460	Phenylacetate-CoA oxygenase
F9278_RS03830	COG3396	Phenylacetate-CoA oxygenase
F9278_RS03870	COG1653	transport
F9278_RS03875	COG1175	transmembrane transport
F9278_RS03880	COG0395	ABC-type sugar transport system, permease component
F9278_RS03885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS03890	COG4948	Mandelate Racemase Muconate Lactonizing
F9278_RS03895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F9278_RS03940	COG0714	Associated with various cellular activities
F9278_RS03950	COG1181	Belongs to the D-alanine--D-alanine ligase family
F9278_RS03960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F9278_RS03965	COG4948	Mandelate Racemase Muconate Lactonizing
F9278_RS03980	COG0747	negative chemotaxis
F9278_RS03985	COG0601	transmembrane transport
F9278_RS03990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS04010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F9278_RS04040	COG1174	glycine betaine transport
F9278_RS04045	COG1174	glycine betaine transport
F9278_RS04060	COG2986	histidine ammonia-lyase
F9278_RS04070	COG1404	Belongs to the peptidase S8 family
F9278_RS04080	COG0135	phosphoribosylanthranilate isomerase activity
F9278_RS04085	COG3835	regulator
F9278_RS04100	COG1316	TRANSCRIPTIONal
F9278_RS04175	COG1609	Transcriptional regulator
F9278_RS04185	COG1609	Transcriptional regulator
F9278_RS04190	COG4948	Mandelate Racemase Muconate Lactonizing
F9278_RS04200	COG1175	transmembrane transport
F9278_RS04205	COG0395	ABC-type sugar transport system, permease component
F9278_RS04215	COG0673	inositol 2-dehydrogenase activity
F9278_RS04225	COG0745	RESPONSE REGULATOR receiver
F9278_RS04235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F9278_RS04240	COG1414	Transcriptional regulator
F9278_RS04285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F9278_RS04295	COG2197	response regulator
F9278_RS04305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F9278_RS04310	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F9278_RS04315	COG3971	2-oxopent-4-enoate hydratase activity
F9278_RS04320	COG1414	Transcriptional regulator
F9278_RS04340	COG1063	alcohol dehydrogenase
F9278_RS04355	COG3940	Belongs to the glycosyl hydrolase 43 family
F9278_RS04385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F9278_RS04560	COG1120	ATPase activity
F9278_RS04630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS04635	COG1116	anion transmembrane transporter activity
F9278_RS04650	COG2072	flavoprotein involved in K transport
F9278_RS04655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F9278_RS04660	COG1132	(ABC) transporter
F9278_RS04670	COG1301	dicarboxylic acid transport
F9278_RS04690	COG1132	(ABC) transporter
F9278_RS04710	COG1946	Acyl-CoA thioesterase
F9278_RS04720	COG2018	Roadblock/LC7 domain
F9278_RS04775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F9278_RS04800	COG1940	carbohydrate kinase activity
F9278_RS04810	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS04875	COG1024	Enoyl-CoA hydratase
F9278_RS04880	COG1960	acyl-CoA dehydrogenase activity
F9278_RS04890	COG1063	alcohol dehydrogenase
F9278_RS04900	COG3384	dioxygenase
F9278_RS04935	COG2267	carboxylic ester hydrolase activity
F9278_RS04965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS04970	COG1414	Transcriptional regulator
F9278_RS05000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F9278_RS05030	COG1309	transcriptional regulator
F9278_RS05075	COG2197	response regulator
F9278_RS05125	COG2815	serine threonine protein kinase
F9278_RS05125	COG0515	serine threonine protein kinase
F9278_RS05170	COG3033	Beta-eliminating lyase
F9278_RS05220	COG1172	Belongs to the binding-protein-dependent transport system permease family
F9278_RS05225	COG1129	ABC transporter
F9278_RS05285	COG4821	SIS domain
F9278_RS05290	COG1737	Transcriptional regulator
F9278_RS05310	COG1175	transmembrane transport
F9278_RS05315	COG0395	ABC-type sugar transport system, permease component
F9278_RS05335	COG1472	Belongs to the glycosyl hydrolase 3 family
F9278_RS05395	COG0395	ABC-type sugar transport system, permease component
F9278_RS05400	COG1175	transmembrane transport
F9278_RS05410	COG1609	Transcriptional regulator
F9278_RS05425	COG1846	Transcriptional regulator
F9278_RS05445	COG1609	Transcriptional regulator
F9278_RS05510	COG1960	acyl-CoA dehydrogenase activity
F9278_RS05515	COG1960	acyl-CoA dehydrogenase activity
F9278_RS05535	COG3344	reverse transcriptase
F9278_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS05595	COG1960	acyl-CoA dehydrogenase activity
F9278_RS05605	COG0242	peptide deformylase activity
F9278_RS05615	COG3442	glutamine amidotransferase
F9278_RS05620	COG0205	6-phosphofructokinase activity
F9278_RS05635	COG0515	serine threonine protein kinase
F9278_RS05635	COG2815	serine threonine protein kinase
F9278_RS05645	COG3275	phosphorelay sensor kinase activity
F9278_RS05650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F9278_RS05670	COG1834	amidinotransferase
F9278_RS05675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F9278_RS05715	COG0829	nickel cation binding
F9278_RS05720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F9278_RS05730	COG0804	urea catabolic process
F9278_RS05735	COG0832	Belongs to the urease beta subunit family
F9278_RS05740	COG0831	urea catabolic process
F9278_RS05745	COG1309	transcriptional regulator
F9278_RS05760	COG0740	serine-type endopeptidase activity
F9278_RS05795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F9278_RS05800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F9278_RS05805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F9278_RS05815	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F9278_RS05820	COG2226	methyltransferase
F9278_RS05835	COG0577	efflux transmembrane transporter activity
F9278_RS05835	COG1136	(ABC) transporter
F9278_RS05840	COG1136	(ABC) transporter
F9278_RS05840	COG0577	efflux transmembrane transporter activity
F9278_RS05850	COG0456	acetyltransferase
F9278_RS05875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F9278_RS05880	COG3663	DNA glycosylase
F9278_RS05890	COG1940	carbohydrate kinase activity
F9278_RS05895	COG2188	Transcriptional regulator
F9278_RS05900	COG1595	DNA-templated transcription, initiation
F9278_RS05905	COG2267	carboxylic ester hydrolase activity
F9278_RS05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F9278_RS05965	COG1522	sequence-specific DNA binding
F9278_RS05970	COG0419	ATPase involved in DNA repair
F9278_RS05975	COG0420	3'-5' exonuclease activity
F9278_RS05980	COG1739	Uncharacterized protein family UPF0029
F9278_RS05995	COG1832	CoA-binding protein
F9278_RS06015	COG0542	response to heat
F9278_RS06040	COG0110	maltose O-acetyltransferase activity
F9278_RS06080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F9278_RS06090	COG0183	Belongs to the thiolase family
F9278_RS06125	COG1968	undecaprenyl-diphosphatase activity
F9278_RS06145	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS06155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F9278_RS06170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F9278_RS06180	COG2318	DinB family
F9278_RS06200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F9278_RS06245	COG0583	DNA-binding transcription factor activity
F9278_RS06250	COG0697	spore germination
F9278_RS06290	COG0384	phenazine biosynthesis protein PhzF
F9278_RS06315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F9278_RS06315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F9278_RS06325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F9278_RS06345	COG1716	ATPase activity
F9278_RS06365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F9278_RS06400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F9278_RS06410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F9278_RS06435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F9278_RS06440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F9278_RS06455	COG2018	Roadblock/LC7 domain
F9278_RS06470	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS06475	COG0531	amino acid
F9278_RS06505	COG2814	Major facilitator Superfamily
F9278_RS06510	COG4336	lyase activity
F9278_RS06515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F9278_RS06520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F9278_RS06525	COG1984	allophanate hydrolase subunit 2
F9278_RS06530	COG2755	lipolytic protein G-D-S-L family
F9278_RS06535	COG0438	transferase activity, transferring glycosyl groups
F9278_RS06570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F9278_RS06575	COG2364	Membrane
F9278_RS06585	COG2270	Major facilitator Superfamily
F9278_RS06600	COG1216	Glycosyl transferase, family 2
F9278_RS06630	COG1960	acyl-CoA dehydrogenase activity
F9278_RS06640	COG1309	transcriptional regulator
F9278_RS06680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F9278_RS06685	COG0140	phosphoribosyl-ATP diphosphatase activity
F9278_RS06690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F9278_RS06695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F9278_RS06695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F9278_RS06700	COG3201	nicotinamide mononucleotide transporter
F9278_RS06710	COG1595	DNA-templated transcription, initiation
F9278_RS06720	COG1846	Transcriptional regulator
F9278_RS06720	COG1940	carbohydrate kinase activity
F9278_RS06725	COG2223	nitrite transmembrane transporter activity
F9278_RS06750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F9278_RS06765	COG3842	ATPase activity
F9278_RS06775	COG1176	ABC-type spermidine putrescine transport system, permease component I
F9278_RS06785	COG2188	Transcriptional regulator
F9278_RS06810	COG2390	Transcriptional regulator
F9278_RS06815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F9278_RS06820	COG2409	Drug exporters of the RND superfamily
F9278_RS06830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F9278_RS06845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F9278_RS06855	COG1758	RNA polymerase activity
F9278_RS06860	COG0194	GDP metabolic process
F9278_RS06870	COG0284	orotidine-5'-phosphate decarboxylase activity
F9278_RS06875	COG0167	dihydroorotate dehydrogenase activity
F9278_RS06880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F9278_RS06885	COG0505	Belongs to the CarA family
F9278_RS06895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F9278_RS06900	COG0540	Belongs to the ATCase OTCase family
F9278_RS06905	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F9278_RS06915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F9278_RS06920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F9278_RS06925	COG0006	proline dipeptidase activity
F9278_RS06935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F9278_RS06945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F9278_RS06950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F9278_RS06955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F9278_RS06960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F9278_RS06965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F9278_RS06970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F9278_RS06985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F9278_RS07000	COG0124	histidyl-tRNA synthetase
F9278_RS07010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F9278_RS07015	COG1196	nuclear chromosome segregation
F9278_RS07020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F9278_RS07030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F9278_RS07035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F9278_RS07040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F9278_RS07050	COG2255	four-way junction helicase activity
F9278_RS07055	COG0632	four-way junction helicase activity
F9278_RS07060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F9278_RS07065	COG0217	transcriptional regulatory protein
F9278_RS07070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F9278_RS07075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F9278_RS07085	COG0438	transferase activity, transferring glycosyl groups
F9278_RS07095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F9278_RS07120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F9278_RS07135	COG5002	protein histidine kinase activity
F9278_RS07135	COG2176	DNA-directed DNA polymerase activity
F9278_RS07165	COG0395	ABC-type sugar transport system, permease component
F9278_RS07170	COG1175	transmembrane transport
F9278_RS07220	COG0512	Glutamine amidotransferase of anthranilate synthase
F9278_RS07220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F9278_RS07280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F9278_RS07280	COG1648	precorrin-2 dehydrogenase activity
F9278_RS07285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F9278_RS07300	COG1464	Belongs to the NlpA lipoprotein family
F9278_RS07305	COG2011	ABC-type metal ion transport system permease component
F9278_RS07310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F9278_RS07335	COG0584	glycerophosphoryl diester phosphodiesterase
F9278_RS07340	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS07340	COG0204	Acyl-transferase
F9278_RS07345	COG0477	Major facilitator Superfamily
F9278_RS07360	COG0165	Argininosuccinate lyase
F9278_RS07390	COG1438	arginine binding
F9278_RS07395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F9278_RS07400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F9278_RS07405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F9278_RS07410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F9278_RS07460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F9278_RS07465	COG0697	spore germination
F9278_RS07525	COG1649	PFAM Uncharacterised BCR, COG1649
F9278_RS07555	COG0072	phenylalanine-tRNA ligase activity
F9278_RS07555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F9278_RS07560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F9278_RS07565	COG5002	protein histidine kinase activity
F9278_RS07570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F9278_RS07575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F9278_RS07580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F9278_RS07585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F9278_RS07610	COG1404	Belongs to the peptidase S8 family
F9278_RS07635	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS07645	COG2186	Transcriptional regulator
F9278_RS07650	COG0531	amino acid
F9278_RS07655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F9278_RS07690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F9278_RS07745	COG1309	transcriptional regulator
F9278_RS07775	COG0805	protein transport
F9278_RS07780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F9278_RS07810	COG0545	Peptidyl-prolyl cis-trans isomerase
F9278_RS07815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F9278_RS07825	COG1609	Transcriptional regulator
F9278_RS07830	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F9278_RS07835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F9278_RS07850	COG4122	O-methyltransferase activity
F9278_RS07855	COG1222	aaa ATPase
F9278_RS07880	COG1994	Peptidase M50
F9278_RS07880	COG0517	IMP dehydrogenase activity
F9278_RS07890	COG2197	response regulator
F9278_RS07895	COG4166	transmembrane transport
F9278_RS07900	COG4166	transmembrane transport
F9278_RS07915	COG0646	methionine synthase
F9278_RS07915	COG1410	methionine synthase
F9278_RS07920	COG1414	Transcriptional regulator
F9278_RS07925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F9278_RS07930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F9278_RS07935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F9278_RS07940	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
F9278_RS07950	COG1129	ABC transporter
F9278_RS07960	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F9278_RS07965	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
F9278_RS07975	COG0235	Class ii aldolase
F9278_RS07975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F9278_RS07995	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F9278_RS08000	COG0402	S-adenosylhomocysteine deaminase activity
F9278_RS08005	COG2186	Transcriptional regulator
F9278_RS08020	COG0215	cysteine-tRNA ligase activity
F9278_RS08035	COG0588	phosphoglycerate mutase activity
F9278_RS08040	COG0598	Magnesium transport protein CorA
F9278_RS08050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS08055	COG0667	Aldo Keto reductase
F9278_RS08085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F9278_RS08100	COG0308	aminopeptidase N
F9278_RS08105	COG3012	SEC-C Motif Domain Protein
F9278_RS08110	COG2186	Transcriptional regulator
F9278_RS08115	COG3265	gluconokinase activity
F9278_RS08130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F9278_RS08135	COG3573	Dehydrogenase
F9278_RS08145	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F9278_RS08150	COG2149	membrane
F9278_RS08165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F9278_RS08190	COG3876	Protein conserved in bacteria
F9278_RS08220	COG0789	Transcriptional regulator
F9278_RS08250	COG1960	acyl-CoA dehydrogenase activity
F9278_RS08295	COG2851	Citrate transporter
F9278_RS08300	COG0243	molybdopterin cofactor binding
F9278_RS08305	COG1309	transcriptional regulator
F9278_RS08310	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F9278_RS08315	COG2188	Transcriptional regulator
F9278_RS08340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS08355	COG1595	DNA-templated transcription, initiation
F9278_RS08375	COG0515	serine threonine protein kinase
F9278_RS08375	COG2815	serine threonine protein kinase
F9278_RS08380	COG2755	lipolytic protein G-D-S-L family
F9278_RS08400	COG0463	Glycosyl transferase, family 2
F9278_RS08410	COG0726	polysaccharide deacetylase
F9278_RS08430	COG1725	Transcriptional regulator
F9278_RS08435	COG0456	acetyltransferase
F9278_RS08465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F9278_RS08470	COG0587	DNA-directed DNA polymerase activity
F9278_RS08500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS08515	COG1799	cell septum assembly
F9278_RS08520	COG1960	acyl-CoA dehydrogenase activity
F9278_RS08525	COG0477	Major facilitator Superfamily
F9278_RS08535	COG0671	phosphoesterase, PA-phosphatase related
F9278_RS08545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F9278_RS08560	COG0438	transferase activity, transferring glycosyl groups
F9278_RS08590	COG1652	LysM domain
F9278_RS08605	COG1160	GTP binding
F9278_RS08615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F9278_RS08645	COG3541	Predicted nucleotidyltransferase
F9278_RS08650	COG3541	Predicted nucleotidyltransferase
F9278_RS08660	COG0494	nUDIX hydrolase
F9278_RS08665	COG1187	pseudouridine synthase activity
F9278_RS08670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F9278_RS08675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F9278_RS08690	COG0686	Belongs to the AlaDH PNT family
F9278_RS08700	COG0494	nUDIX hydrolase
F9278_RS08705	COG0504	CTP synthase activity
F9278_RS08710	COG3387	PFAM Glycoside hydrolase 15-related
F9278_RS08725	COG0438	transferase activity, transferring glycosyl groups
F9278_RS08730	COG0497	DNA recombination
F9278_RS08735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F9278_RS08760	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS08765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS08770	COG0647	UMP catabolic process
F9278_RS08810	COG2094	Belongs to the DNA glycosylase MPG family
F9278_RS08820	COG1881	PFAM PEBP family protein
F9278_RS08840	COG1119	ATPase activity
F9278_RS08860	COG2197	response regulator
F9278_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS08875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F9278_RS08885	COG1716	ATPase activity
F9278_RS08885	COG1131	(ABC) transporter
F9278_RS08885	COG0842	Transport permease protein
F9278_RS08895	COG3830	Belongs to the UPF0237 family
F9278_RS08895	COG0560	Phosphoserine phosphatase
F9278_RS08900	COG0588	phosphoglycerate mutase activity
F9278_RS08920	COG2807	transmembrane transport
F9278_RS08925	COG2186	Transcriptional regulator
F9278_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS08995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F9278_RS09015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F9278_RS09020	COG3344	reverse transcriptase
F9278_RS09025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F9278_RS09040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS09075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F9278_RS09100	COG1966	Carbon starvation protein
F9278_RS09115	COG1595	DNA-templated transcription, initiation
F9278_RS09125	COG3387	PFAM Glycoside hydrolase 15-related
F9278_RS09175	COG0488	(ABC) transporter
F9278_RS09195	COG0235	Class ii aldolase
F9278_RS09235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F9278_RS09240	COG1492	cobalamin metabolic process
F9278_RS09255	COG1797	cobyrinic acid a,c-diamide synthase activity
F9278_RS09285	COG1609	Transcriptional regulator
F9278_RS09295	COG0395	ABC-type sugar transport system, permease component
F9278_RS09300	COG4209	transmembrane transport
F9278_RS09310	COG1126	abc transporter atp-binding protein
F9278_RS09315	COG0765	amino acid transport
F9278_RS09325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F9278_RS09330	COG0456	acetyltransferase
F9278_RS09335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F9278_RS09340	COG1917	Cupin 2, conserved barrel domain protein
F9278_RS09345	COG5285	phytanoyl-CoA dioxygenase
F9278_RS09355	COG1846	Transcriptional regulator
F9278_RS09385	COG1414	Transcriptional regulator
F9278_RS09390	COG0768	penicillin binding
F9278_RS09395	COG2252	PERMEase
F9278_RS09400	COG1595	DNA-templated transcription, initiation
F9278_RS09415	COG4733	cellulase activity
F9278_RS09435	COG4677	pectinesterase activity
F9278_RS09440	COG4677	pectinesterase activity
F9278_RS09445	COG3866	Pectate lyase
F9278_RS09450	COG2755	lipolytic protein G-D-S-L family
F9278_RS09465	COG3507	Belongs to the glycosyl hydrolase 43 family
F9278_RS09480	COG3866	Pectate lyase
F9278_RS09485	COG0395	ABC-type sugar transport system, permease component
F9278_RS09490	COG1175	transmembrane transport
F9278_RS09500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS09505	COG1802	Transcriptional regulator
F9278_RS09525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS09530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F9278_RS09565	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F9278_RS09620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS09630	COG1595	DNA-templated transcription, initiation
F9278_RS09640	COG2171	N-acyltransferase activity
F9278_RS09655	COG3226	Transcriptional regulator
F9278_RS09660	COG2076	Multidrug Resistance protein
F9278_RS09670	COG2151	metal-sulfur cluster biosynthetic enzyme
F9278_RS09675	COG0822	iron-sulfur transferase activity
F9278_RS09680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F9278_RS09685	COG0396	ATPase activity
F9278_RS09695	COG0719	Fe-S assembly protein
F9278_RS09710	COG2746	aminoglycoside 3-N-acetyltransferase activity
F9278_RS09725	COG1612	heme a metabolic process
F9278_RS09745	COG0109	protoheme IX farnesyltransferase activity
F9278_RS09755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F9278_RS09760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F9278_RS09775	COG0363	glucosamine-6-phosphate deaminase activity
F9278_RS09800	COG0166	Belongs to the GPI family
F9278_RS09810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F9278_RS09815	COG0149	triose-phosphate isomerase activity
F9278_RS09820	COG0126	phosphoglycerate kinase activity
F9278_RS09825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F9278_RS09835	COG1481	regulation of sporulation
F9278_RS09840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F9278_RS09845	COG1660	Displays ATPase and GTPase activities
F9278_RS09850	COG0322	excinuclease ABC activity
F9278_RS09860	COG2197	response regulator
F9278_RS09865	COG4585	Histidine kinase
F9278_RS09880	COG2197	response regulator
F9278_RS09900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F9278_RS09915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F9278_RS09920	COG0765	amino acid transport
F9278_RS09930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F9278_RS09945	COG0387	Pfam Sodium calcium exchanger
F9278_RS09965	COG0556	nucleotide-excision repair
F9278_RS09975	COG0584	glycerophosphoryl diester phosphodiesterase
F9278_RS09980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F9278_RS09990	COG2313	pseudouridylate synthase activity
F9278_RS09995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F9278_RS09995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F9278_RS10000	COG2226	methyltransferase
F9278_RS10005	COG0598	Magnesium transport protein CorA
F9278_RS10060	COG1132	(ABC) transporter
F9278_RS10075	COG0402	S-adenosylhomocysteine deaminase activity
F9278_RS10115	COG1953	Uracil, thiamine, allantoin
F9278_RS10120	COG1802	Transcriptional regulator
F9278_RS10125	COG2267	carboxylic ester hydrolase activity
F9278_RS10165	COG0237	dephospho-CoA kinase activity
F9278_RS10180	COG0539	negative regulation of cytoplasmic translation
F9278_RS10185	COG2226	methyltransferase
F9278_RS10190	COG1643	Atp-dependent helicase
F9278_RS10225	COG2050	protein possibly involved in aromatic compounds catabolism
F9278_RS10255	COG0411	ABC transporter
F9278_RS10290	COG0737	Belongs to the 5'-nucleotidase family
F9278_RS10315	COG4566	intracellular signal transduction
F9278_RS10320	COG0287	Prephenate dehydrogenase
F9278_RS10320	COG1605	Chorismate mutase
F9278_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS10360	COG0183	Belongs to the thiolase family
F9278_RS10365	COG1309	transcriptional regulator
F9278_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS10375	COG1960	acyl-CoA dehydrogenase activity
F9278_RS10415	COG0069	glutamate synthase activity
F9278_RS10415	COG0070	glutamate synthase
F9278_RS10415	COG0067	glutamate synthase
F9278_RS10445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS10460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F9278_RS10470	COG0159	tryptophan synthase activity
F9278_RS10475	COG0133	tryptophan synthase activity
F9278_RS10485	COG0134	indole-3-glycerol-phosphate synthase activity
F9278_RS10505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F9278_RS10510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F9278_RS10520	COG0107	imidazoleglycerol-phosphate synthase activity
F9278_RS10525	COG0251	oxidation-reduction process
F9278_RS10530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F9278_RS10535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F9278_RS10540	COG0131	Imidazoleglycerol-phosphate dehydratase
F9278_RS10545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F9278_RS10550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F9278_RS10570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F9278_RS10590	COG1432	Conserved Protein
F9278_RS10595	COG0587	DNA-directed DNA polymerase activity
F9278_RS10640	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS10660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F9278_RS10675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F9278_RS10680	COG3599	regulation of cell shape
F9278_RS10690	COG1799	cell septum assembly
F9278_RS10700	COG1496	oxidoreductase activity
F9278_RS10705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F9278_RS10710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F9278_RS10715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F9278_RS10725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F9278_RS10730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F9278_RS10740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F9278_RS10745	COG0768	penicillin binding
F9278_RS10755	COG0275	rRNA processing
F9278_RS10765	COG0714	Associated with various cellular activities
F9278_RS10785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F9278_RS10795	COG4133	protoheme IX ABC transporter activity
F9278_RS10805	COG1309	transcriptional regulator
F9278_RS10825	COG0352	thiamine-phosphate diphosphorylase activity
F9278_RS10835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F9278_RS10845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F9278_RS10845	COG2022	thiamine diphosphate biosynthetic process
F9278_RS10855	COG2022	thiamine diphosphate biosynthetic process
F9278_RS10860	COG2815	serine threonine protein kinase
F9278_RS10860	COG0515	serine threonine protein kinase
F9278_RS10865	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F9278_RS10880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F9278_RS10885	COG2193	ferroxidase activity
F9278_RS10890	COG0243	molybdopterin cofactor binding
F9278_RS10895	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F9278_RS10920	COG0205	6-phosphofructokinase activity
F9278_RS10930	COG4585	Histidine kinase
F9278_RS10955	COG1940	carbohydrate kinase activity
F9278_RS10965	COG0003	Pfam Anion-transporting ATPase
F9278_RS11040	COG2205	protein histidine kinase activity
F9278_RS11045	COG0745	RESPONSE REGULATOR receiver
F9278_RS11055	COG1929	Belongs to the glycerate kinase type-1 family
F9278_RS11060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F9278_RS11070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F9278_RS11075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F9278_RS11080	COG0723	plastoquinol--plastocyanin reductase activity
F9278_RS11085	COG2010	Cytochrome c
F9278_RS11090	COG1845	cytochrome c oxidase, subunit III
F9278_RS11100	COG1376	ErfK ybiS ycfS ynhG family protein
F9278_RS11110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F9278_RS11115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F9278_RS11125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F9278_RS11150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F9278_RS11155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F9278_RS11155	COG0515	serine threonine protein kinase
F9278_RS11160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F9278_RS11165	COG2197	response regulator
F9278_RS11170	COG4585	Histidine kinase
F9278_RS11225	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F9278_RS11245	COG0438	transferase activity, transferring glycosyl groups
F9278_RS11255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F9278_RS11260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F9278_RS11265	COG0508	dehydrogenase complex catalyzes the overall conversion of
F9278_RS11275	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F9278_RS11300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F9278_RS11325	COG0321	lipoyl(octanoyl) transferase activity
F9278_RS11330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F9278_RS11350	COG0174	glutamine synthetase
F9278_RS11415	COG0745	RESPONSE REGULATOR receiver
F9278_RS11450	COG1309	transcriptional regulator
F9278_RS11470	COG3693	PFAM glycoside hydrolase, family 10
F9278_RS11490	COG0583	DNA-binding transcription factor activity
F9278_RS11510	COG0366	Alpha amylase catalytic
F9278_RS11515	COG3833	ABC-type maltose transport systems, permease component
F9278_RS11520	COG1175	transmembrane transport
F9278_RS11530	COG1609	Transcriptional regulator
F9278_RS11540	COG0583	DNA-binding transcription factor activity
F9278_RS11550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F9278_RS11580	COG0174	glutamine synthetase
F9278_RS11600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F9278_RS11600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F9278_RS11605	COG2814	Major facilitator Superfamily
F9278_RS11620	COG0477	Major facilitator Superfamily
F9278_RS11625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F9278_RS11650	COG1994	Peptidase M50
F9278_RS11705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS11710	COG1120	ATPase activity
F9278_RS11715	COG2822	iron ion transport
F9278_RS11720	COG2837	iron assimilation
F9278_RS11725	COG0672	)-iron permease
F9278_RS11770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F9278_RS11785	COG3540	Alkaline phosphatase
F9278_RS11790	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS11800	COG1136	(ABC) transporter
F9278_RS11815	COG2259	Doxx family
F9278_RS11830	COG2409	Drug exporters of the RND superfamily
F9278_RS11835	COG4585	Histidine kinase
F9278_RS11840	COG2197	response regulator
F9278_RS11845	COG3940	Belongs to the glycosyl hydrolase 43 family
F9278_RS11855	COG3940	Belongs to the glycosyl hydrolase 43 family
F9278_RS11880	COG4585	Histidine kinase
F9278_RS11885	COG2197	response regulator
F9278_RS11890	COG1201	RNA secondary structure unwinding
F9278_RS12010	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F9278_RS12085	COG3022	response to hydroperoxide
F9278_RS12090	COG0800	Aldolase
F9278_RS12105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F9278_RS12115	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS12125	COG2030	dehydratase
F9278_RS12130	COG2197	response regulator
F9278_RS12135	COG0477	Major facilitator Superfamily
F9278_RS12165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS12185	COG0438	transferase activity, transferring glycosyl groups
F9278_RS12190	COG1309	transcriptional regulator
F9278_RS12240	COG3845	ABC transporter
F9278_RS12265	COG1404	Belongs to the peptidase S8 family
F9278_RS12295	COG0183	Belongs to the thiolase family
F9278_RS12300	COG2124	cytochrome p450
F9278_RS12320	COG4122	O-methyltransferase activity
F9278_RS12340	COG0443	Heat shock 70 kDa protein
F9278_RS12345	COG3344	reverse transcriptase
F9278_RS12365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F9278_RS12410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F9278_RS12415	COG0583	DNA-binding transcription factor activity
F9278_RS12425	COG3344	reverse transcriptase
F9278_RS12460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F9278_RS12470	COG0586	Pfam SNARE associated Golgi protein
F9278_RS12480	COG1358	cellular component organization or biogenesis
F9278_RS12530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F9278_RS12535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F9278_RS12545	COG0477	Major facilitator Superfamily
F9278_RS12550	COG1309	transcriptional regulator
F9278_RS12590	COG0789	Transcriptional regulator
F9278_RS12620	COG1741	Belongs to the pirin family
F9278_RS12635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F9278_RS12640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F9278_RS12645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F9278_RS12670	COG1309	transcriptional regulator
F9278_RS12710	COG2130	NADP-dependent
F9278_RS12745	COG3344	reverse transcriptase
F9278_RS12750	COG1172	Belongs to the binding-protein-dependent transport system permease family
F9278_RS12755	COG1172	Belongs to the binding-protein-dependent transport system permease family
F9278_RS12765	COG1879	ABC-type sugar transport system periplasmic component
F9278_RS12770	COG1609	Transcriptional regulator
F9278_RS12800	COG1129	ABC transporter
F9278_RS12805	COG4214	carbohydrate transport
F9278_RS12815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F9278_RS12870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F9278_RS12915	COG0730	response to heat
F9278_RS12960	COG1414	Transcriptional regulator
F9278_RS12995	COG4981	capsule polysaccharide biosynthetic process
F9278_RS13015	COG2835	tetraacyldisaccharide 4'-kinase activity
F9278_RS13090	COG2186	Transcriptional regulator
F9278_RS13100	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS13105	COG0825	malonyl-CoA metabolic process
F9278_RS13105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F9278_RS13110	COG1077	Cell shape determining protein MreB Mrl
F9278_RS13130	COG0641	radical SAM
F9278_RS13140	COG3629	intracellular signal transduction
F9278_RS13140	COG3903	Transcriptional regulator
F9278_RS13145	COG1053	succinate dehydrogenase
F9278_RS13185	COG0395	ABC-type sugar transport system, permease component
F9278_RS13190	COG1175	transmembrane transport
F9278_RS13200	COG1621	beta-fructofuranosidase activity
F9278_RS13215	COG1609	Transcriptional regulator
F9278_RS13315	COG1070	Carbohydrate kinase
F9278_RS13330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F9278_RS13335	COG0358	DNA primase activity
F9278_RS13345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F9278_RS13355	COG2949	membrane
F9278_RS13365	COG0243	molybdopterin cofactor binding
F9278_RS13390	COG0701	Predicted permease
F9278_RS13425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F9278_RS13430	COG2146	nitrite reductase [NAD(P)H] activity
F9278_RS13430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F9278_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS13445	COG0659	secondary active sulfate transmembrane transporter activity
F9278_RS13465	COG0642	Histidine kinase
F9278_RS13475	COG1819	glycosyl
F9278_RS13495	COG1136	(ABC) transporter
F9278_RS13505	COG0574	Belongs to the PEP-utilizing enzyme family
F9278_RS13505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F9278_RS13510	COG1940	carbohydrate kinase activity
F9278_RS13510	COG1846	Transcriptional regulator
F9278_RS13515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
F9278_RS13575	COG0667	Aldo Keto reductase
F9278_RS13590	COG0423	glycine-tRNA ligase activity
F9278_RS13595	COG0803	Belongs to the bacterial solute-binding protein 9 family
F9278_RS13595	COG3443	Belongs to the bacterial solute-binding protein 9 family
F9278_RS13600	COG1121	(ABC) transporter
F9278_RS13605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F9278_RS13630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F9278_RS13635	COG1381	Involved in DNA repair and RecF pathway recombination
F9278_RS13650	COG3629	intracellular signal transduction
F9278_RS13650	COG3903	Transcriptional regulator
F9278_RS13675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F9278_RS13685	COG2186	Transcriptional regulator
F9278_RS13700	COG0747	negative chemotaxis
F9278_RS13710	COG0444	Belongs to the ABC transporter superfamily
F9278_RS13715	COG4608	Belongs to the ABC transporter superfamily
F9278_RS13720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS13730	COG2197	response regulator
F9278_RS13735	COG4585	Histidine kinase
F9278_RS13740	COG2409	Drug exporters of the RND superfamily
F9278_RS13750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F9278_RS13770	COG2723	6-phospho-beta-galactosidase activity
F9278_RS13790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F9278_RS13830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F9278_RS13840	COG1414	Transcriptional regulator
F9278_RS13845	COG4948	Mandelate Racemase Muconate Lactonizing
F9278_RS13860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F9278_RS13865	COG1234	tRNA 3'-trailer cleavage
F9278_RS13870	COG0537	adenosine 5'-monophosphoramidase activity
F9278_RS13875	COG0793	Belongs to the peptidase S41A family
F9278_RS13875	COG4946	Tricorn protease homolog
F9278_RS13900	COG0484	heat shock protein binding
F9278_RS13905	COG1420	regulation of RNA biosynthetic process
F9278_RS13950	COG0481	GTPase activity
F9278_RS13955	COG0268	Binds directly to 16S ribosomal RNA
F9278_RS13980	COG1555	photosystem II stabilization
F9278_RS13985	COG1307	EDD domain protein, DegV family
F9278_RS13995	COG0495	leucyl-tRNA aminoacylation
F9278_RS14010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F9278_RS14030	COG0588	phosphoglycerate mutase activity
F9278_RS14035	COG0799	negative regulation of ribosome biogenesis
F9278_RS14045	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F9278_RS14055	COG0501	Belongs to the peptidase M48B family
F9278_RS14070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F9278_RS14080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F9278_RS14090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F9278_RS14095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F9278_RS14100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F9278_RS14105	COG1530	ribonuclease E activity
F9278_RS14150	COG2186	Transcriptional regulator
F9278_RS14205	COG0772	Belongs to the SEDS family
F9278_RS14210	COG0768	penicillin binding
F9278_RS14225	COG1077	Cell shape determining protein MreB Mrl
F9278_RS14230	COG0105	UTP biosynthetic process
F9278_RS14240	COG0285	dihydrofolate synthase activity
F9278_RS14245	COG0525	valine-tRNA ligase activity
F9278_RS14255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F9278_RS14260	COG0740	serine-type endopeptidase activity
F9278_RS14265	COG0740	serine-type endopeptidase activity
F9278_RS14270	COG0544	peptidyl-prolyl cis-trans isomerase activity
F9278_RS14290	COG3594	Acyltransferase
F9278_RS14305	COG4552	Acetyltransferase involved in intracellular survival and related
F9278_RS14320	COG1113	amino acid transport
F9278_RS14325	COG0515	serine threonine protein kinase
F9278_RS14350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS14355	COG1116	anion transmembrane transporter activity
F9278_RS14360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS14380	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F9278_RS14450	COG0697	spore germination
F9278_RS14455	COG1846	Transcriptional regulator
F9278_RS14460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F9278_RS14490	COG1136	(ABC) transporter
F9278_RS14500	COG0668	transmembrane transport
F9278_RS14525	COG1175	transmembrane transport
F9278_RS14530	COG0395	ABC-type sugar transport system, permease component
F9278_RS14535	COG1486	melibiose metabolic process
F9278_RS14550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F9278_RS14580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F9278_RS14610	COG0629	single-stranded DNA binding
F9278_RS14640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F9278_RS14650	COG1051	belongs to the nudix hydrolase family
F9278_RS14665	COG2813	Specifically methylates the guanine in position
F9278_RS14720	COG2771	luxR family
F9278_RS14740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F9278_RS14800	COG1960	acyl-CoA dehydrogenase activity
F9278_RS14820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F9278_RS14900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F9278_RS14980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F9278_RS15040	COG0494	nUDIX hydrolase
F9278_RS15200	COG2337	Toxic component of a toxin-antitoxin (TA) module
F9278_RS15320	COG0151	Belongs to the GarS family
F9278_RS15505	COG0714	Associated with various cellular activities
F9278_RS15520	COG5433	transposase activity
F9278_RS15630	COG0305	Participates in initiation and elongation during chromosome replication
F9278_RS15650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F9278_RS16040	COG2304	oxidoreductase activity
F9278_RS16090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F9278_RS16110	COG0438	transferase activity, transferring glycosyl groups
F9278_RS16135	COG0492	ferredoxin-NADP+ reductase activity
F9278_RS16190	COG3962	Belongs to the TPP enzyme family
F9278_RS16195	COG3718	enzyme involved in inositol metabolism
F9278_RS16205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F9278_RS16225	COG2409	Drug exporters of the RND superfamily
F9278_RS16250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F9278_RS16295	COG1129	ABC transporter
F9278_RS16310	COG1869	D-ribose catabolic process
F9278_RS16340	COG1674	ftsk spoiiie
F9278_RS16350	COG1840	ABC-type Fe3 transport system, periplasmic component
F9278_RS16360	COG3842	ATPase activity
F9278_RS16370	COG3629	intracellular signal transduction
F9278_RS16370	COG3903	Transcriptional regulator
F9278_RS16465	COG0673	inositol 2-dehydrogenase activity
F9278_RS16500	COG3340	Belongs to the peptidase S51 family
F9278_RS16505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F9278_RS16510	COG1472	Belongs to the glycosyl hydrolase 3 family
F9278_RS16555	COG2356	endonuclease I
F9278_RS16575	COG0644	oxidoreductase
F9278_RS16620	COG0028	Belongs to the TPP enzyme family
F9278_RS16630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F9278_RS16645	COG1946	Acyl-CoA thioesterase
F9278_RS16700	COG1051	belongs to the nudix hydrolase family
F9278_RS16705	COG1309	transcriptional regulator
F9278_RS16710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F9278_RS16725	COG1960	acyl-CoA dehydrogenase activity
F9278_RS16735	COG2375	cellular response to nickel ion
F9278_RS16735	COG1132	(ABC) transporter
F9278_RS16740	COG0076	glutamate decarboxylase activity
F9278_RS16745	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F9278_RS16780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F9278_RS16785	COG0589	response to stress
F9278_RS16795	COG4977	sequence-specific DNA binding
F9278_RS16800	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F9278_RS16860	COG0395	ABC-type sugar transport system, permease component
F9278_RS16930	COG3345	alpha-galactosidase
F9278_RS16935	COG0395	ABC-type sugar transport system, permease component
F9278_RS16940	COG1175	transmembrane transport
F9278_RS16945	COG1653	transport
F9278_RS16955	COG0745	RESPONSE REGULATOR receiver
F9278_RS16965	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F9278_RS16985	COG0406	alpha-ribazole phosphatase activity
F9278_RS17035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS17050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F9278_RS17065	COG3344	reverse transcriptase
F9278_RS17080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F9278_RS17085	COG0765	amino acid transport
F9278_RS17090	COG0765	amino acid transport
F9278_RS17095	COG1126	abc transporter atp-binding protein
F9278_RS17110	COG2197	response regulator
F9278_RS17120	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS17130	COG3397	chitin binding
F9278_RS17185	COG1940	carbohydrate kinase activity
F9278_RS17190	COG0673	inositol 2-dehydrogenase activity
F9278_RS17195	COG4702	Belongs to the UPF0303 family
F9278_RS17205	COG0706	membrane insertase activity
F9278_RS17215	COG3764	Sortase (surface protein transpeptidase)
F9278_RS17270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F9278_RS17275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F9278_RS17335	COG2733	membrane
F9278_RS17365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F9278_RS17400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F9278_RS17410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F9278_RS17415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F9278_RS17420	COG1263	PTS System
F9278_RS17430	COG1263	PTS System
F9278_RS17435	COG1234	tRNA 3'-trailer cleavage
F9278_RS17470	COG1113	amino acid transport
F9278_RS17480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F9278_RS17490	COG1335	isochorismatase
F9278_RS17525	COG0277	FAD linked oxidase domain protein
F9278_RS17535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F9278_RS17545	COG1174	glycine betaine transport
F9278_RS17555	COG1174	glycine betaine transport
F9278_RS17575	COG0596	Alpha beta hydrolase
F9278_RS17575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F9278_RS17590	COG3654	unkown
F9278_RS17700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F9278_RS17715	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F9278_RS17720	COG0395	ABC-type sugar transport system, permease component
F9278_RS17740	COG1678	Uncharacterized ACR, COG1678
F9278_RS17745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F9278_RS17750	COG0776	regulation of translation
F9278_RS17760	COG3973	AAA domain
F9278_RS17785	COG2223	nitrite transmembrane transporter activity
F9278_RS17790	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS17835	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F9278_RS17840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F9278_RS17880	COG3321	synthase
F9278_RS17880	COG0604	alcohol dehydrogenase
F9278_RS17880	COG3321	synthase
F9278_RS17880	COG0604	alcohol dehydrogenase
F9278_RS17885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F9278_RS17925	COG0477	Major facilitator Superfamily
F9278_RS17940	COG0546	phosphoglycolate phosphatase activity
F9278_RS17955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F9278_RS17980	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS18135	COG0583	DNA-binding transcription factor activity
F9278_RS18160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F9278_RS18165	COG0793	Belongs to the peptidase S41A family
F9278_RS18175	COG2884	Cell division ATP-binding protein ftsE
F9278_RS18190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F9278_RS18195	COG0515	serine threonine protein kinase
F9278_RS18200	COG0515	serine threonine protein kinase
F9278_RS18210	COG1653	transport
F9278_RS18215	COG1175	transmembrane transport
F9278_RS18220	COG0395	ABC-type sugar transport system, permease component
F9278_RS18225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F9278_RS18225	COG0463	Glycosyl transferase, family 2
F9278_RS18230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F9278_RS18235	COG1215	transferase activity, transferring glycosyl groups
F9278_RS18250	COG1764	response to oxidative stress
F9278_RS18255	COG1846	Transcriptional regulator
F9278_RS18320	COG1134	teichoic acid transport
F9278_RS18330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F9278_RS18330	COG0515	serine threonine protein kinase
F9278_RS18335	COG2902	Dehydrogenase
F9278_RS18365	COG0653	protein targeting
F9278_RS18375	COG3214	Protein conserved in bacteria
F9278_RS18380	COG2197	response regulator
F9278_RS18385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F9278_RS18400	COG0823	Involved in the tonB-independent uptake of proteins
F9278_RS18405	COG5000	phosphorelay sensor kinase activity
F9278_RS18405	COG5002	protein histidine kinase activity
F9278_RS18410	COG0745	RESPONSE REGULATOR receiver
F9278_RS18415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F9278_RS18435	COG0714	Associated with various cellular activities
F9278_RS18480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F9278_RS18495	COG1482	cell wall glycoprotein biosynthetic process
F9278_RS18505	COG2835	tetraacyldisaccharide 4'-kinase activity
F9278_RS18510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F9278_RS18560	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F9278_RS18565	COG0778	Nitroreductase
F9278_RS18565	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F9278_RS18575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F9278_RS18595	COG1316	TRANSCRIPTIONal
F9278_RS18610	COG1316	TRANSCRIPTIONal
F9278_RS18615	COG1316	TRANSCRIPTIONal
F9278_RS18695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F9278_RS18725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F9278_RS18740	COG2205	protein histidine kinase activity
F9278_RS18745	COG0745	RESPONSE REGULATOR receiver
F9278_RS18750	COG3104	oligopeptide transport
F9278_RS18780	COG1366	Belongs to the anti-sigma-factor antagonist family
F9278_RS18785	COG1191	sigma factor activity
F9278_RS18800	COG1228	amidohydrolase
F9278_RS18810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F9278_RS18815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F9278_RS18865	COG2986	histidine ammonia-lyase
F9278_RS18880	COG2755	lipolytic protein G-D-S-L family
F9278_RS18885	COG0183	Belongs to the thiolase family
F9278_RS18920	COG0577	efflux transmembrane transporter activity
F9278_RS18920	COG1136	(ABC) transporter
F9278_RS18925	COG0577	efflux transmembrane transporter activity
F9278_RS18930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F9278_RS18935	COG1252	NADH dehydrogenase
F9278_RS18955	COG0148	phosphopyruvate hydratase activity
F9278_RS19015	COG4974	Belongs to the 'phage' integrase family
F9278_RS19035	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F9278_RS19070	COG0577	efflux transmembrane transporter activity
F9278_RS19075	COG1136	(ABC) transporter
F9278_RS19080	COG0477	Major facilitator Superfamily
F9278_RS19090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F9278_RS19120	COG4585	Histidine kinase
F9278_RS19130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F9278_RS19135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F9278_RS19140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F9278_RS19145	COG0193	aminoacyl-tRNA hydrolase activity
F9278_RS19155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F9278_RS19165	COG1309	transcriptional regulator
F9278_RS19170	COG0438	transferase activity, transferring glycosyl groups
F9278_RS19180	COG0477	Major facilitator Superfamily
F9278_RS19185	COG4106	trans-aconitate 2-methyltransferase activity
F9278_RS19195	COG2197	response regulator
F9278_RS19215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F9278_RS19290	COG0488	(ABC) transporter
F9278_RS19320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F9278_RS19325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F9278_RS19340	COG0084	hydrolase, TatD family'
F9278_RS19365	COG0768	penicillin binding
F9278_RS19380	COG0442	prolyl-tRNA aminoacylation
F9278_RS19405	COG1764	response to oxidative stress
F9278_RS19410	COG1846	Transcriptional regulator
F9278_RS19415	COG1122	ATPase activity
F9278_RS19425	COG0310	cobalt ion transport
F9278_RS19460	COG2409	Drug exporters of the RND superfamily
F9278_RS19470	COG0793	Belongs to the peptidase S41A family
F9278_RS19470	COG4946	Tricorn protease homolog
F9278_RS19485	COG2267	carboxylic ester hydrolase activity
F9278_RS19490	COG2072	flavoprotein involved in K transport
F9278_RS19500	COG0708	Exodeoxyribonuclease III
F9278_RS19525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F9278_RS19530	COG0315	cyclic pyranopterin monophosphate synthase activity
F9278_RS19530	COG0521	Mo-molybdopterin cofactor biosynthetic process
F9278_RS19535	COG0315	cyclic pyranopterin monophosphate synthase activity
F9278_RS19545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F9278_RS19550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F9278_RS19555	COG3344	reverse transcriptase
F9278_RS19580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F9278_RS19590	COG1970	mechanosensitive ion channel activity
F9278_RS19615	COG1376	ErfK ybiS ycfS ynhG family protein
F9278_RS19630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F9278_RS19630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F9278_RS19645	COG0477	Major facilitator Superfamily
F9278_RS19670	COG1247	-acetyltransferase
F9278_RS19680	COG3384	dioxygenase
F9278_RS19685	COG1846	Transcriptional regulator
F9278_RS19705	COG1414	Transcriptional regulator
F9278_RS19730	COG4555	ABC transporter
F9278_RS19770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F9278_RS19795	COG0758	DNA mediated transformation
F9278_RS19810	COG0517	IMP dehydrogenase activity
F9278_RS19810	COG0516	GMP reductase activity
F9278_RS19845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F9278_RS19850	COG3344	reverse transcriptase
F9278_RS19855	COG0549	Belongs to the carbamate kinase family
F9278_RS19865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F9278_RS19895	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F9278_RS19990	COG1063	alcohol dehydrogenase
F9278_RS20020	COG0574	Belongs to the PEP-utilizing enzyme family
F9278_RS20020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F9278_RS20060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F9278_RS20150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F9278_RS20160	COG3547	Transposase (IS116 IS110 IS902 family)
F9278_RS20170	COG3344	reverse transcriptase
F9278_RS20180	COG2002	toxin-antitoxin pair type II binding
F9278_RS20240	COG1733	regulation of RNA biosynthetic process
F9278_RS20245	COG0702	epimerase
F9278_RS20270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F9278_RS20295	COG0386	Belongs to the glutathione peroxidase family
F9278_RS20320	COG1686	Belongs to the peptidase S11 family
F9278_RS20365	COG3896	Chloramphenicol phosphotransferase-like protein
F9278_RS20410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F9278_RS20470	COG4257	antibiotic catabolic process
F9278_RS20485	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS20540	COG3903	Transcriptional regulator
F9278_RS20540	COG3629	intracellular signal transduction
F9278_RS20570	COG1024	Enoyl-CoA hydratase
F9278_RS20615	COG0515	serine threonine protein kinase
F9278_RS20615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F9278_RS20630	COG1309	transcriptional regulator
F9278_RS20640	COG1960	acyl-CoA dehydrogenase activity
F9278_RS20660	COG0259	pyridoxamine-phosphate oxidase activity
F9278_RS20700	COG2072	flavoprotein involved in K transport
F9278_RS20710	COG1024	Enoyl-CoA hydratase
F9278_RS20715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F9278_RS20745	COG1960	acyl-CoA dehydrogenase activity
F9278_RS20770	COG1960	acyl-CoA dehydrogenase activity
F9278_RS20775	COG1960	acyl-CoA dehydrogenase activity
F9278_RS20795	COG1366	Belongs to the anti-sigma-factor antagonist family
F9278_RS20840	COG1131	(ABC) transporter
F9278_RS20850	COG2945	thiolester hydrolase activity
F9278_RS20850	COG0596	Alpha beta hydrolase
F9278_RS20860	COG4821	SIS domain
F9278_RS20885	COG0259	pyridoxamine-phosphate oxidase activity
F9278_RS20910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F9278_RS20940	COG0596	Alpha beta hydrolase
F9278_RS21020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F9278_RS21040	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F9278_RS21095	COG0667	Aldo Keto reductase
F9278_RS21120	COG2252	PERMEase
F9278_RS21130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F9278_RS21160	COG2814	Major facilitator Superfamily
F9278_RS21170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F9278_RS21175	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F9278_RS21220	COG1061	Type III restriction enzyme res subunit
F9278_RS21235	COG3973	AAA domain
F9278_RS21305	COG1737	Transcriptional regulator
F9278_RS21315	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F9278_RS21375	COG0459	protein refolding
F9278_RS21380	COG1278	Cold shock
F9278_RS21395	COG0463	Glycosyl transferase, family 2
F9278_RS21415	COG2182	Extracellular solute-binding protein
F9278_RS21425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F9278_RS21455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F9278_RS21475	COG0436	Aminotransferase
F9278_RS21480	COG2814	Major facilitator Superfamily
F9278_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS21490	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS21495	COG1917	Cupin 2, conserved barrel domain protein
F9278_RS21530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F9278_RS21530	COG0723	plastoquinol--plastocyanin reductase activity
F9278_RS21555	COG3842	ATPase activity
F9278_RS21580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F9278_RS21585	COG0215	cysteine-tRNA ligase activity
F9278_RS21590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F9278_RS21595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F9278_RS21605	COG1329	Transcriptional regulator
F9278_RS21625	COG5002	protein histidine kinase activity
F9278_RS21685	COG0588	phosphoglycerate mutase activity
F9278_RS21700	COG2207	Transcriptional regulator
F9278_RS21700	COG1917	Cupin 2, conserved barrel domain protein
F9278_RS21710	COG0438	transferase activity, transferring glycosyl groups
F9278_RS21815	COG2318	DinB family
F9278_RS21830	COG1309	transcriptional regulator
F9278_RS21865	COG2188	Transcriptional regulator
F9278_RS21875	COG2188	Transcriptional regulator
F9278_RS21880	COG4552	Acetyltransferase involved in intracellular survival and related
F9278_RS21890	COG1490	D-aminoacyl-tRNA deacylase activity
F9278_RS21900	COG0735	belongs to the Fur family
F9278_RS21905	COG3485	protocatechuate 3,4-dioxygenase
F9278_RS21950	COG2897	thiosulfate sulfurtransferase activity
F9278_RS21980	COG0745	RESPONSE REGULATOR receiver
F9278_RS21985	COG1609	Transcriptional regulator
F9278_RS21995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F9278_RS22005	COG0745	RESPONSE REGULATOR receiver
F9278_RS22050	COG0737	Belongs to the 5'-nucleotidase family
F9278_RS22055	COG0456	acetyltransferase
F9278_RS22060	COG1725	Transcriptional regulator
F9278_RS22080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F9278_RS22115	COG1937	Protein conserved in bacteria
F9278_RS22125	COG0306	phosphate transporter
F9278_RS22130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F9278_RS22150	COG0277	FAD linked oxidase domain protein
F9278_RS22155	COG0671	phosphoesterase, PA-phosphatase related
F9278_RS22160	COG1196	nuclear chromosome segregation
F9278_RS22160	COG0741	lytic transglycosylase activity
F9278_RS22160	COG0739	heme binding
F9278_RS22250	COG4585	Histidine kinase
F9278_RS22255	COG2197	response regulator
F9278_RS22295	COG1252	NADH dehydrogenase
F9278_RS22325	COG0579	oxidoreductase
F9278_RS22330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F9278_RS22365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F9278_RS22380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F9278_RS22380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F9278_RS22405	COG1136	(ABC) transporter
F9278_RS22445	COG3408	Glycogen debranching enzyme
F9278_RS22535	COG2362	D-Aminopeptidase
F9278_RS22570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F9278_RS22580	COG1181	Belongs to the D-alanine--D-alanine ligase family
F9278_RS22585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F9278_RS22655	COG0513	Belongs to the DEAD box helicase family
F9278_RS22690	COG1643	Atp-dependent helicase
F9278_RS22715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F9278_RS22725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F9278_RS22775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F9278_RS22780	COG0047	phosphoribosylformylglycinamidine synthase activity
F9278_RS22785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F9278_RS22820	COG2197	response regulator
F9278_RS22830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F9278_RS22845	COG0151	Belongs to the GarS family
F9278_RS22910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F9278_RS22950	COG2372	response to copper ion
F9278_RS22950	COG1276	copper resistance
F9278_RS23005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F9278_RS23035	COG1191	sigma factor activity
F9278_RS23040	COG1191	sigma factor activity
F9278_RS23055	COG0477	Major facilitator Superfamily
F9278_RS23065	COG3467	pyridoxamine 5'-phosphate
F9278_RS23075	COG0477	Major facilitator Superfamily
F9278_RS23080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F9278_RS23090	COG2205	protein histidine kinase activity
F9278_RS23095	COG0745	RESPONSE REGULATOR receiver
F9278_RS23215	COG0784	Response regulator, receiver
F9278_RS23220	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS23225	COG1595	DNA-templated transcription, initiation
F9278_RS23320	COG2188	Transcriptional regulator
F9278_RS23355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F9278_RS23370	COG0653	protein targeting
F9278_RS23390	COG0006	proline dipeptidase activity
F9278_RS23395	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F9278_RS23410	COG0641	radical SAM
F9278_RS23445	COG1999	signal sequence binding
F9278_RS23460	COG2837	iron assimilation
F9278_RS23465	COG0077	Prephenate dehydratase
F9278_RS23470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F9278_RS23475	COG0561	phosphatase activity
F9278_RS23505	COG1131	(ABC) transporter
F9278_RS23525	COG0789	Transcriptional regulator
F9278_RS23530	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F9278_RS23550	COG2824	Alkylphosphonate utilization operon protein PhnA
F9278_RS23560	COG0659	secondary active sulfate transmembrane transporter activity
F9278_RS23595	COG3260	NADH ubiquinone oxidoreductase 20
F9278_RS23605	COG0650	Formate hydrogenlyase subunit 4
F9278_RS23615	COG0651	ATP synthesis coupled electron transport
F9278_RS23620	COG3261	NADH dehydrogenase
F9278_RS23620	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
F9278_RS23640	COG2239	Acts as a magnesium transporter
F9278_RS23670	COG0456	acetyltransferase
F9278_RS23700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F9278_RS23735	COG0305	Participates in initiation and elongation during chromosome replication
F9278_RS23755	COG0561	phosphatase activity
F9278_RS23760	COG0739	heme binding
F9278_RS23760	COG1196	nuclear chromosome segregation
F9278_RS23760	COG0741	lytic transglycosylase activity
F9278_RS23765	COG4988	ABC transporter
F9278_RS23770	COG1294	oxidase, subunit
F9278_RS23775	COG1271	oxidase subunit
F9278_RS23780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F9278_RS23785	COG1609	Transcriptional regulator
F9278_RS23800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F9278_RS23825	COG0662	Cupin 2, conserved barrel domain protein
F9278_RS23830	COG1950	PFAM Membrane protein of
F9278_RS23835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F9278_RS23840	COG0626	cystathionine gamma-synthase activity
F9278_RS24020	COG0508	dehydrogenase complex catalyzes the overall conversion of
F9278_RS24025	COG0022	dehydrogenase e1 component
F9278_RS24035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F9278_RS24040	COG0515	serine threonine protein kinase
F9278_RS24045	COG0515	serine threonine protein kinase
F9278_RS24105	COG1522	sequence-specific DNA binding
F9278_RS24110	COG1309	transcriptional regulator
F9278_RS24115	COG1250	3-hydroxyacyl-CoA dehydrogenase
F9278_RS24170	COG1716	ATPase activity
F9278_RS24175	COG1716	ATPase activity
F9278_RS24200	COG0515	serine threonine protein kinase
F9278_RS24210	COG3764	Sortase (surface protein transpeptidase)
F9278_RS24215	COG3764	Sortase (surface protein transpeptidase)
F9278_RS24230	COG3764	Sortase (surface protein transpeptidase)
F9278_RS24245	COG0705	Rhomboid family
F9278_RS24270	COG0515	serine threonine protein kinase
F9278_RS24300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F9278_RS24305	COG0187	DNA topoisomerase II activity
F9278_RS24310	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F9278_RS24315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F9278_RS24320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F9278_RS24325	COG0592	DNA-directed DNA polymerase activity
F9278_RS24335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F9278_RS24350	COG0594	ribonuclease P activity
F9278_RS24355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F9278_RS24360	COG0706	membrane insertase activity
F9278_RS24370	COG0357	Ribosomal RNA small subunit methyltransferase G
F9278_RS24375	COG1192	Involved in chromosome partitioning
F9278_RS24390	COG3118	belongs to the thioredoxin family
F9278_RS24395	COG0492	ferredoxin-NADP+ reductase activity
F9278_RS24405	COG1595	DNA-templated transcription, initiation
F9278_RS24410	COG2815	serine threonine protein kinase
F9278_RS24410	COG0515	serine threonine protein kinase
F9278_RS24425	COG0617	tRNA 3'-terminal CCA addition
F9278_RS24435	COG1260	myo-inositol-1-phosphate synthase
F9278_RS24445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F9278_RS24470	COG0360	Binds together with S18 to 16S ribosomal RNA
F9278_RS24475	COG0629	single-stranded DNA binding
F9278_RS24480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F9278_RS24485	COG0359	binds to the 23S rRNA
F9278_RS24495	COG0305	Participates in initiation and elongation during chromosome replication
F9278_RS24540	COG1362	aminopeptidase activity
F9278_RS24545	COG1960	acyl-CoA dehydrogenase activity
F9278_RS24555	COG1741	Belongs to the pirin family
F9278_RS24580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F9278_RS24635	COG2340	Cysteine-rich secretory protein family
F9278_RS24640	COG3866	Pectate lyase
F9278_RS24670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F9278_RS24690	COG1289	transmembrane transporter activity
F9278_RS24705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F9278_RS24710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F9278_RS24735	COG2205	protein histidine kinase activity
F9278_RS24740	COG0745	RESPONSE REGULATOR receiver
F9278_RS24760	COG4249	Peptidase C14 caspase catalytic subunit p20
F9278_RS24760	COG2319	Wd-40 repeat
F9278_RS24785	COG1595	DNA-templated transcription, initiation
F9278_RS24910	COG0494	nUDIX hydrolase
F9278_RS24985	COG0137	argininosuccinate synthase activity
F9278_RS25010	COG1309	transcriptional regulator
F9278_RS25120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F9278_RS25200	COG0515	serine threonine protein kinase
F9278_RS25200	COG2815	serine threonine protein kinase
F9278_RS25215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F9278_RS25270	COG4585	Histidine kinase
F9278_RS25290	COG1609	Transcriptional regulator
F9278_RS25365	COG3973	AAA domain
F9278_RS25395	COG0596	Alpha beta hydrolase
F9278_RS25400	COG2764	glyoxalase bleomycin resistance protein dioxygenase
F9278_RS25415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS25430	COG0513	Belongs to the DEAD box helicase family
F9278_RS25435	COG1278	Cold shock
F9278_RS25485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F9278_RS25500	COG0662	Cupin 2, conserved barrel domain protein
F9278_RS25545	COG2072	flavoprotein involved in K transport
F9278_RS25555	COG1309	transcriptional regulator
F9278_RS25560	COG4214	carbohydrate transport
F9278_RS25565	COG1129	ABC transporter
F9278_RS25570	COG4213	ABC transporter substrate-binding protein
F9278_RS25580	COG0702	epimerase
F9278_RS25610	COG2188	Transcriptional regulator
F9278_RS25675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F9278_RS25680	COG0070	glutamate synthase
F9278_RS25680	COG0069	glutamate synthase activity
F9278_RS25680	COG0067	glutamate synthase
F9278_RS25700	COG0726	polysaccharide deacetylase
F9278_RS25710	COG0513	Belongs to the DEAD box helicase family
F9278_RS25715	COG1278	Cold shock
F9278_RS25730	COG2197	response regulator
F9278_RS25800	COG1401	restriction endodeoxyribonuclease activity
F9278_RS25830	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS25865	COG0202	RNA polymerase activity
F9278_RS25905	COG3209	COG3209 Rhs family protein
F9278_RS25930	COG1276	copper resistance
F9278_RS25930	COG2372	response to copper ion
F9278_RS26000	COG0659	secondary active sulfate transmembrane transporter activity
F9278_RS26005	COG0789	Transcriptional regulator
F9278_RS26020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F9278_RS26055	COG2268	Band 7 protein
F9278_RS26060	COG1585	Membrane protein implicated in regulation of membrane protease activity
F9278_RS26070	COG1366	Belongs to the anti-sigma-factor antagonist family
F9278_RS26080	COG2255	four-way junction helicase activity
F9278_RS26140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F9278_RS26225	COG0745	RESPONSE REGULATOR receiver
F9278_RS26230	COG5002	protein histidine kinase activity
F9278_RS26250	COG0717	Belongs to the dCTP deaminase family
F9278_RS26330	COG2181	nitrate reductase activity
F9278_RS26330	COG0247	lactate metabolic process
F9278_RS26335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F9278_RS26340	COG0443	Heat shock 70 kDa protein
F9278_RS26345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F9278_RS26350	COG0484	heat shock protein binding
F9278_RS26355	COG0789	Transcriptional regulator
F9278_RS26410	COG4213	ABC transporter substrate-binding protein
F9278_RS26415	COG1305	Transglutaminase-like
F9278_RS26460	COG0542	response to heat
F9278_RS26475	COG4115	mRNA cleavage
F9278_RS26480	COG2161	toxin-antitoxin pair type II binding
F9278_RS26510	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F9278_RS26520	COG2017	converts alpha-aldose to the beta-anomer
F9278_RS26525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F9278_RS26530	COG0191	fructose-bisphosphate aldolase activity
F9278_RS26535	COG0477	Major facilitator Superfamily
F9278_RS26545	COG3483	tryptophan 2,3-dioxygenase activity
F9278_RS26550	COG3844	kynureninase activity
F9278_RS26570	COG4585	Histidine kinase
F9278_RS26575	COG2197	response regulator
F9278_RS26580	COG4585	Histidine kinase
F9278_RS26585	COG2197	response regulator
F9278_RS26645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F9278_RS26660	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F9278_RS26705	COG1215	transferase activity, transferring glycosyl groups
F9278_RS26710	COG1802	Transcriptional regulator
F9278_RS26720	COG0693	protein deglycase activity
F9278_RS26745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F9278_RS26750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F9278_RS26790	COG5002	protein histidine kinase activity
F9278_RS26795	COG0745	RESPONSE REGULATOR receiver
F9278_RS26810	COG1595	DNA-templated transcription, initiation
F9278_RS26850	COG0523	cobalamin synthesis protein
F9278_RS26860	COG0701	Predicted permease
F9278_RS26875	COG2319	Wd-40 repeat
F9278_RS26875	COG4249	Peptidase C14 caspase catalytic subunit p20
F9278_RS26900	COG2124	cytochrome p450
F9278_RS26940	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F9278_RS26950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F9278_RS26965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F9278_RS26980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F9278_RS27100	COG1408	metallophosphoesterase
F9278_RS27125	COG0003	Pfam Anion-transporting ATPase
F9278_RS27140	COG0251	oxidation-reduction process
F9278_RS27150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F9278_RS27185	COG2267	carboxylic ester hydrolase activity
F9278_RS27195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F9278_RS27200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F9278_RS27265	COG1111	helicase
F9278_RS27265	COG1205	dead DEAH box helicase
F9278_RS27270	COG1366	Belongs to the anti-sigma-factor antagonist family
F9278_RS27280	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F9278_RS27305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F9278_RS27305	COG1754	DNA topoisomerase type I activity
F9278_RS27310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F9278_RS27315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F9278_RS27415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F9278_RS27420	COG1216	Glycosyl transferase, family 2
F9278_RS27430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F9278_RS27445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F9278_RS27520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F9278_RS27520	COG0515	serine threonine protein kinase
F9278_RS27525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F9278_RS27540	COG0210	DNA helicase
F9278_RS27575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F9278_RS27585	COG0515	serine threonine protein kinase
F9278_RS27585	COG2815	serine threonine protein kinase
F9278_RS27665	COG3344	reverse transcriptase
F9278_RS27710	COG1228	amidohydrolase
F9278_RS27730	COG1484	DNA-dependent DNA replication
F9278_RS27865	COG0305	Participates in initiation and elongation during chromosome replication
F9278_RS28015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F9278_RS28060	COG3209	COG3209 Rhs family protein
F9278_RS28080	COG2801	Transposase and inactivated derivatives
F9278_RS28105	COG0577	efflux transmembrane transporter activity
F9278_RS28105	COG1136	(ABC) transporter
F9278_RS28110	COG1136	(ABC) transporter
F9278_RS28110	COG0577	efflux transmembrane transporter activity
F9278_RS28140	COG2986	histidine ammonia-lyase
F9278_RS28155	COG0475	glutathione-regulated potassium exporter activity
F9278_RS28245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F9278_RS28250	COG2197	response regulator
F9278_RS28260	COG3903	Transcriptional regulator
F9278_RS28260	COG3629	intracellular signal transduction
F9278_RS28280	COG0667	Aldo Keto reductase
F9278_RS28340	COG4585	Histidine kinase
F9278_RS28365	COG3415	Transposase
F9278_RS28375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F9278_RS28410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F9278_RS28430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F9278_RS28510	COG1396	sequence-specific DNA binding
F9278_RS28520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F9278_RS28535	COG0069	glutamate synthase activity
F9278_RS28540	COG2218	PFAM glutamate synthase alpha subunit domain protein
F9278_RS28545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F9278_RS28555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS28565	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS28570	COG0596	Alpha beta hydrolase
F9278_RS28585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F9278_RS28600	COG1802	Transcriptional regulator
F9278_RS28625	COG2226	methyltransferase
F9278_RS28630	COG1619	proteins homologs of microcin C7 resistance protein MccF
F9278_RS28675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F9278_RS28680	COG2264	protein methyltransferase activity
F9278_RS28780	COG0739	heme binding
F9278_RS28785	COG0583	DNA-binding transcription factor activity
F9278_RS28790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F9278_RS28795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F9278_RS28815	COG0515	serine threonine protein kinase
F9278_RS28830	COG1653	transport
F9278_RS28865	COG3903	Transcriptional regulator
F9278_RS28865	COG3629	intracellular signal transduction
F9278_RS28870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F9278_RS28870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F9278_RS28890	COG1136	(ABC) transporter
F9278_RS28890	COG0577	efflux transmembrane transporter activity
F9278_RS28910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F9278_RS28915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F9278_RS28920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F9278_RS28925	COG0254	rRNA binding
F9278_RS28935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F9278_RS28955	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS28960	COG2318	DinB family
F9278_RS28985	COG0076	glutamate decarboxylase activity
F9278_RS29000	COG0789	Transcriptional regulator
F9278_RS29015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F9278_RS29020	COG2027	D-alanyl-D-alanine carboxypeptidase
F9278_RS29030	COG0037	tRNA processing
F9278_RS29045	COG0302	gtp cyclohydrolase
F9278_RS29060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F9278_RS29075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F9278_RS29075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F9278_RS29100	COG0649	NAD binding
F9278_RS29115	COG2197	response regulator
F9278_RS29120	COG0640	Transcriptional regulator
F9278_RS29135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F9278_RS29140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F9278_RS29150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F9278_RS29170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F9278_RS29195	COG0739	heme binding
F9278_RS29215	COG2205	protein histidine kinase activity
F9278_RS29220	COG0745	RESPONSE REGULATOR receiver
F9278_RS29230	COG1595	DNA-templated transcription, initiation
F9278_RS29235	COG1194	a g-specific adenine glycosylase
F9278_RS29250	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F9278_RS29275	COG0248	Ppx GppA phosphatase
F9278_RS29280	COG1082	Xylose isomerase domain protein TIM barrel
F9278_RS29285	COG1309	transcriptional regulator
F9278_RS29290	COG0129	dihydroxy-acid dehydratase activity
F9278_RS29300	COG4991	sh3 domain protein
F9278_RS29320	COG0659	secondary active sulfate transmembrane transporter activity
F9278_RS29325	COG1129	ABC transporter
F9278_RS29325	COG0842	Transport permease protein
F9278_RS29335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F9278_RS29340	COG0180	Tryptophanyl-tRNA synthetase
F9278_RS29365	COG3344	reverse transcriptase
F9278_RS29370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F9278_RS29380	COG0123	including yeast histone deacetylase and acetoin utilization protein
F9278_RS29430	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F9278_RS29440	COG0181	hydroxymethylbilane synthase activity
F9278_RS29445	COG1648	precorrin-2 dehydrogenase activity
F9278_RS29445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F9278_RS29465	COG0113	porphobilinogen synthase activity
F9278_RS29525	COG0018	arginyl-trna synthetase
F9278_RS29535	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F9278_RS29555	COG1690	Belongs to the RtcB family
F9278_RS29575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS29585	COG0438	transferase activity, transferring glycosyl groups
F9278_RS29595	COG2205	protein histidine kinase activity
F9278_RS29640	COG0436	Aminotransferase
F9278_RS29685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F9278_RS29690	COG0406	alpha-ribazole phosphatase activity
F9278_RS29700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F9278_RS29710	COG1333	cytochrome c biogenesis protein
F9278_RS29715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F9278_RS29770	COG1725	Transcriptional regulator
F9278_RS29805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F9278_RS29820	COG0163	prenyltransferase activity
F9278_RS29830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F9278_RS29845	COG1309	transcriptional regulator
F9278_RS29910	COG1278	Cold shock
F9278_RS29915	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F9278_RS29930	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F9278_RS29955	COG2226	methyltransferase
F9278_RS29985	COG0791	NLP P60 protein
F9278_RS29995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F9278_RS30000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F9278_RS30005	COG0649	NAD binding
F9278_RS30015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F9278_RS30020	COG1034	ATP synthesis coupled electron transport
F9278_RS30025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F9278_RS30030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F9278_RS30035	COG0839	Belongs to the complex I subunit 6 family
F9278_RS30040	COG0713	ATP synthesis coupled electron transport
F9278_RS30045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F9278_RS30055	COG1007	ATP synthesis coupled electron transport
F9278_RS30060	COG0514	ATP-dependent DNA helicase (RecQ)
F9278_RS30075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F9278_RS30090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS30105	COG2188	Transcriptional regulator
F9278_RS30120	COG0492	ferredoxin-NADP+ reductase activity
F9278_RS30125	COG0561	phosphatase activity
F9278_RS30135	COG0142	geranyltranstransferase activity
F9278_RS30160	COG0655	NAD(P)H dehydrogenase (quinone) activity
F9278_RS30165	COG0154	amidase activity
F9278_RS30200	COG0702	epimerase
F9278_RS30205	COG1733	regulation of RNA biosynthetic process
F9278_RS30210	COG1013	pyruvate-flavodoxin oxidoreductase activity
F9278_RS30215	COG0674	pyruvate-flavodoxin oxidoreductase activity
F9278_RS30215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F9278_RS30235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F9278_RS30240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F9278_RS30245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F9278_RS30250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F9278_RS30255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F9278_RS30260	COG0839	Belongs to the complex I subunit 6 family
F9278_RS30265	COG0713	ATP synthesis coupled electron transport
F9278_RS30280	COG1007	ATP synthesis coupled electron transport
F9278_RS30285	COG0501	Belongs to the peptidase M48B family
F9278_RS30290	COG3304	Inner membrane component domain
F9278_RS30305	COG2261	transglycosylase associated protein
F9278_RS30310	COG1666	GTP binding
F9278_RS30350	COG1674	ftsk spoiiie
F9278_RS30350	COG0531	amino acid
F9278_RS30390	COG2188	Transcriptional regulator
F9278_RS30405	COG0702	epimerase
F9278_RS30415	COG0402	S-adenosylhomocysteine deaminase activity
F9278_RS30430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F9278_RS30435	COG2030	dehydratase
F9278_RS30445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F9278_RS30450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F9278_RS30455	COG0436	Aminotransferase
F9278_RS30480	COG0081	regulation of translation
F9278_RS30490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F9278_RS30495	COG0222	ribosome binding
F9278_RS30505	COG0085	RNA polymerase activity
F9278_RS30510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F9278_RS30520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F9278_RS30525	COG0049	tRNA binding
F9278_RS30530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F9278_RS30535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F9278_RS30585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F9278_RS30610	COG0051	transcription antitermination factor activity, RNA binding
F9278_RS30615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F9278_RS30620	COG0088	Forms part of the polypeptide exit tunnel
F9278_RS30625	COG0089	rRNA binding
F9278_RS30630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F9278_RS30635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F9278_RS30640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F9278_RS30645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F9278_RS30650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F9278_RS30655	COG0255	Belongs to the universal ribosomal protein uL29 family
F9278_RS30660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F9278_RS30665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F9278_RS30670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F9278_RS30675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F9278_RS30680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F9278_RS30690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F9278_RS30695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F9278_RS30700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F9278_RS30705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F9278_RS30710	COG1841	ribosomal large subunit assembly
F9278_RS30715	COG0200	Binds to the 23S rRNA
F9278_RS30725	COG0563	adenylate kinase activity
F9278_RS30735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F9278_RS30740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F9278_RS30745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F9278_RS30750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F9278_RS30755	COG0202	RNA polymerase activity
F9278_RS30760	COG0203	ribosomal protein L17
F9278_RS30765	COG0101	tRNA pseudouridine synthase activity
F9278_RS30780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F9278_RS30785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F9278_RS30790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F9278_RS30800	COG1072	(Pantothenic acid kinase))
F9278_RS30820	COG0736	holo-[acyl-carrier-protein] synthase activity
F9278_RS30825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F9278_RS30830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F9278_RS30840	COG0802	atpase or kinase
F9278_RS30860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F9278_RS30900	COG1472	Belongs to the glycosyl hydrolase 3 family
F9278_RS30910	COG1175	transmembrane transport
F9278_RS30915	COG1653	transport
F9278_RS30930	COG1316	TRANSCRIPTIONal
F9278_RS30940	COG4941	Belongs to the sigma-70 factor family
F9278_RS30950	COG0726	polysaccharide deacetylase
F9278_RS30955	COG0726	polysaccharide deacetylase
F9278_RS30960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F9278_RS30965	COG0459	protein refolding
F9278_RS30975	COG4221	oxidoreductase activity
F9278_RS30985	COG0583	DNA-binding transcription factor activity
F9278_RS30995	COG2197	response regulator
F9278_RS31000	COG1595	DNA-templated transcription, initiation
F9278_RS31010	COG0516	GMP reductase activity
F9278_RS31020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F9278_RS31035	COG0515	serine threonine protein kinase
F9278_RS31040	COG0515	serine threonine protein kinase
F9278_RS31040	COG2815	serine threonine protein kinase
F9278_RS31045	COG0515	serine threonine protein kinase
F9278_RS31050	COG0438	transferase activity, transferring glycosyl groups
F9278_RS31070	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS31090	COG0519	Catalyzes the synthesis of GMP from XMP
F9278_RS31090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F9278_RS31135	COG2197	response regulator
F9278_RS31140	COG0791	NLP P60 protein
F9278_RS31175	COG0739	heme binding
F9278_RS31180	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F9278_RS31185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS31185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS31200	COG0714	Associated with various cellular activities
F9278_RS31210	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F9278_RS31220	COG0045	succinate-CoA ligase (ADP-forming) activity
F9278_RS31250	COG0138	bifunctional purine biosynthesis protein purh
F9278_RS31255	COG0515	serine threonine protein kinase
F9278_RS31255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F9278_RS31265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F9278_RS31285	COG0039	L-malate dehydrogenase activity
F9278_RS31300	COG0754	glutathionylspermidine amidase activity
F9278_RS31305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F9278_RS31310	COG0180	Tryptophanyl-tRNA synthetase
F9278_RS31330	COG0671	phosphoesterase, PA-phosphatase related
F9278_RS31340	COG1295	ribonuclease BN
F9278_RS31345	COG1686	Belongs to the peptidase S11 family
F9278_RS31390	COG1408	metallophosphoesterase
F9278_RS31410	COG0745	RESPONSE REGULATOR receiver
F9278_RS31485	COG1053	succinate dehydrogenase
F9278_RS31495	COG2009	succinate dehydrogenase
F9278_RS31525	COG1595	DNA-templated transcription, initiation
F9278_RS31535	COG1595	DNA-templated transcription, initiation
F9278_RS31550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS31550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS31570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F9278_RS31580	COG1216	Glycosyl transferase, family 2
F9278_RS31595	COG2089	acid synthase
F9278_RS31610	COG1473	amidohydrolase
F9278_RS31610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F9278_RS31615	COG1744	ABC transporter substrate-binding protein PnrA-like
F9278_RS31620	COG1744	ABC transporter substrate-binding protein PnrA-like
F9278_RS31625	COG3845	ABC transporter
F9278_RS31630	COG4603	Belongs to the binding-protein-dependent transport system permease family
F9278_RS31635	COG1079	Belongs to the binding-protein-dependent transport system permease family
F9278_RS31660	COG2814	Major facilitator Superfamily
F9278_RS31665	COG0583	DNA-binding transcription factor activity
F9278_RS31675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F9278_RS31700	COG2205	protein histidine kinase activity
F9278_RS31705	COG0745	RESPONSE REGULATOR receiver
F9278_RS31710	COG1595	DNA-templated transcription, initiation
F9278_RS31725	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS31730	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS31735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F9278_RS31750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F9278_RS31780	COG4770	biotin carboxylase activity
F9278_RS31790	COG0424	maF-like protein
F9278_RS31800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F9278_RS31810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F9278_RS31820	COG1024	Enoyl-CoA hydratase
F9278_RS31835	COG2986	histidine ammonia-lyase
F9278_RS31850	COG1376	ErfK ybiS ycfS ynhG family protein
F9278_RS31860	COG1136	(ABC) transporter
F9278_RS31865	COG1404	Belongs to the peptidase S8 family
F9278_RS31875	COG1064	alcohol dehydrogenase
F9278_RS31890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F9278_RS31900	COG0501	Belongs to the peptidase M48B family
F9278_RS31920	COG2255	four-way junction helicase activity
F9278_RS31925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F9278_RS31940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F9278_RS31950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F9278_RS31980	COG1331	Highly conserved protein containing a thioredoxin domain
F9278_RS32020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F9278_RS32025	COG2226	methyltransferase
F9278_RS32040	COG1309	transcriptional regulator
F9278_RS32050	COG0477	Major facilitator Superfamily
F9278_RS32060	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F9278_RS32105	COG3853	Toxic anion resistance protein (TelA)
F9278_RS32120	COG0436	Aminotransferase
F9278_RS32130	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F9278_RS32155	COG1414	Transcriptional regulator
F9278_RS32165	COG0251	oxidation-reduction process
F9278_RS32215	COG0596	Alpha beta hydrolase
F9278_RS32265	COG2197	response regulator
F9278_RS32285	COG2885	chlorophyll binding
F9278_RS32290	COG2186	Transcriptional regulator
F9278_RS32365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F9278_RS32375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F9278_RS32395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F9278_RS32405	COG1136	(ABC) transporter
F9278_RS32415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F9278_RS32430	COG3557	Belongs to the UPF0374 family
F9278_RS32435	COG0114	fumarate hydratase activity
F9278_RS32440	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F9278_RS32440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F9278_RS32465	COG1722	exodeoxyribonuclease VII activity
F9278_RS32470	COG1570	exodeoxyribonuclease VII activity
F9278_RS32475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F9278_RS32490	COG0012	GTP binding
F9278_RS32560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F9278_RS32565	COG1053	succinate dehydrogenase
F9278_RS32595	COG1217	gtp-binding protein TYPA
F9278_RS32600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS32605	COG0747	negative chemotaxis
F9278_RS32610	COG0601	transmembrane transport
F9278_RS32620	COG4608	Belongs to the ABC transporter superfamily
F9278_RS32640	COG0747	negative chemotaxis
F9278_RS32645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS32655	COG0601	transmembrane transport
F9278_RS32660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS32665	COG0444	Belongs to the ABC transporter superfamily
F9278_RS32670	COG4608	Belongs to the ABC transporter superfamily
F9278_RS32685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F9278_RS32705	COG1131	(ABC) transporter
F9278_RS32715	COG4585	Histidine kinase
F9278_RS32720	COG2197	response regulator
F9278_RS32755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F9278_RS32765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F9278_RS32775	COG0519	Catalyzes the synthesis of GMP from XMP
F9278_RS32780	COG1024	Enoyl-CoA hydratase
F9278_RS32795	COG1595	DNA-templated transcription, initiation
F9278_RS32805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F9278_RS32810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F9278_RS32835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F9278_RS32845	COG0598	Magnesium transport protein CorA
F9278_RS32860	COG0613	PHP domain protein
F9278_RS32865	COG2095	MarC family integral membrane protein
F9278_RS32875	COG1432	Conserved Protein
F9278_RS32980	COG0210	DNA helicase
F9278_RS33025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F9278_RS33080	COG3480	Lon protease (S16) C-terminal proteolytic domain
F9278_RS33090	COG1615	UPF0182 protein
F9278_RS33125	COG0483	inositol monophosphate 1-phosphatase activity
F9278_RS33140	COG1162	GTPase activity
F9278_RS33145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F9278_RS33155	COG2135	peptidase activity
F9278_RS33165	COG1595	DNA-templated transcription, initiation
F9278_RS33170	COG5662	AntiSigma factor
F9278_RS33200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F9278_RS33200	COG2199	diguanylate cyclase activity
F9278_RS33215	COG0242	peptide deformylase activity
F9278_RS33245	COG1957	nucleoside hydrolase
F9278_RS33265	COG1966	Carbon starvation protein
F9278_RS33270	COG2188	Transcriptional regulator
F9278_RS33280	COG1175	transmembrane transport
F9278_RS33285	COG0395	ABC-type sugar transport system, permease component
F9278_RS33290	COG1472	Belongs to the glycosyl hydrolase 3 family
F9278_RS33295	COG0363	glucosamine-6-phosphate deaminase activity
F9278_RS33315	COG1597	lipid kinase activity
F9278_RS33355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F9278_RS33360	COG0142	geranyltranstransferase activity
F9278_RS33385	COG4941	Belongs to the sigma-70 factor family
F9278_RS33400	COG4977	sequence-specific DNA binding
F9278_RS33405	COG0395	ABC-type sugar transport system, permease component
F9278_RS33410	COG1175	transmembrane transport
F9278_RS33420	COG1609	Transcriptional regulator
F9278_RS33450	COG4106	trans-aconitate 2-methyltransferase activity
F9278_RS33455	COG1126	abc transporter atp-binding protein
F9278_RS33465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F9278_RS33480	COG0604	alcohol dehydrogenase
F9278_RS33515	COG0508	dehydrogenase complex catalyzes the overall conversion of
F9278_RS33515	COG0567	Dehydrogenase, E1 component
F9278_RS33520	COG2205	protein histidine kinase activity
F9278_RS33525	COG0745	RESPONSE REGULATOR receiver
F9278_RS33540	COG2211	Major facilitator Superfamily
F9278_RS33545	COG1309	transcriptional regulator
F9278_RS33555	COG0456	acetyltransferase
F9278_RS33555	COG0454	-acetyltransferase
F9278_RS33560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F9278_RS33635	COG0768	penicillin binding
F9278_RS33650	COG2205	protein histidine kinase activity
F9278_RS33670	COG1793	dna ligase
F9278_RS33670	COG3285	dna ligase
F9278_RS33675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F9278_RS33685	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F9278_RS33700	COG3284	Transcriptional regulator
F9278_RS33760	COG0745	RESPONSE REGULATOR receiver
F9278_RS33765	COG0018	arginyl-trna synthetase
F9278_RS33765	COG0018	arginyl-trna synthetase
F9278_RS33770	COG0019	diaminopimelate decarboxylase activity
F9278_RS33775	COG0460	homoserine dehydrogenase
F9278_RS33780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F9278_RS33785	COG0083	homoserine kinase activity
F9278_RS33805	COG0254	rRNA binding
F9278_RS33810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F9278_RS33815	COG2890	protein-(glutamine-N5) methyltransferase activity
F9278_RS33825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F9278_RS33830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F9278_RS33850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F9278_RS33855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F9278_RS33860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F9278_RS33865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F9278_RS33870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F9278_RS33875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F9278_RS33880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F9278_RS33895	COG2197	response regulator
F9278_RS33900	COG4585	Histidine kinase
F9278_RS33920	COG1250	3-hydroxyacyl-CoA dehydrogenase
F9278_RS33935	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F9278_RS33970	COG0675	Transposase, IS605 OrfB family
F9278_RS33990	COG0183	Belongs to the thiolase family
F9278_RS34010	COG0745	RESPONSE REGULATOR receiver
F9278_RS34085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS34085	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS34125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F9278_RS34130	COG0857	belongs to the CobB CobQ family
F9278_RS34130	COG0280	phosphate acetyltransferase
F9278_RS34135	COG0205	6-phosphofructokinase activity
F9278_RS34150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F9278_RS34155	COG3903	Transcriptional regulator
F9278_RS34155	COG3629	intracellular signal transduction
F9278_RS34175	COG4565	transcriptional regulatory protein
F9278_RS34180	COG3290	protein histidine kinase activity
F9278_RS34185	COG1301	dicarboxylic acid transport
F9278_RS34190	COG0789	Transcriptional regulator
F9278_RS34210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F9278_RS34215	COG3281	Trehalose synthase
F9278_RS34220	COG0366	Alpha amylase catalytic
F9278_RS34225	COG0366	Alpha amylase catalytic
F9278_RS34235	COG0058	SHG alpha-glucan phosphorylase activity
F9278_RS34255	COG1132	(ABC) transporter
F9278_RS34260	COG1132	(ABC) transporter
F9278_RS34265	COG1132	(ABC) transporter
F9278_RS34270	COG1132	(ABC) transporter
F9278_RS34275	COG1131	(ABC) transporter
F9278_RS34280	COG2197	response regulator
F9278_RS34295	COG1376	ErfK ybiS ycfS ynhG family protein
F9278_RS34320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F9278_RS34440	COG0464	growth
F9278_RS34470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F9278_RS34475	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS34505	COG0604	alcohol dehydrogenase
F9278_RS34515	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F9278_RS34530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F9278_RS34535	COG1960	acyl-CoA dehydrogenase activity
F9278_RS34550	COG3251	PFAM MbtH domain protein
F9278_RS34575	COG1960	acyl-CoA dehydrogenase activity
F9278_RS34600	COG2197	response regulator
F9278_RS34605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F9278_RS34620	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F9278_RS34625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F9278_RS34650	COG2124	cytochrome p450
F9278_RS34675	COG2197	response regulator
F9278_RS34680	COG4585	Histidine kinase
F9278_RS34685	COG1760	l-serine dehydratase
F9278_RS34690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F9278_RS34695	COG0509	glycine decarboxylation via glycine cleavage system
F9278_RS34700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F9278_RS34720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS34725	COG4166	transmembrane transport
F9278_RS34735	COG0444	Belongs to the ABC transporter superfamily
F9278_RS34745	COG2860	membrane
F9278_RS34780	COG2132	Multicopper oxidase
F9278_RS34795	COG3023	N-Acetylmuramoyl-L-alanine amidase
F9278_RS34800	COG0482	sulfurtransferase activity
F9278_RS34810	COG1611	Belongs to the LOG family
F9278_RS34825	COG3344	reverse transcriptase
F9278_RS34840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F9278_RS34850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F9278_RS34855	COG0154	amidase activity
F9278_RS34865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F9278_RS34870	COG2409	Drug exporters of the RND superfamily
F9278_RS34875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F9278_RS34890	COG2197	response regulator
F9278_RS34895	COG2133	pyrroloquinoline quinone binding
F9278_RS34900	COG0667	Aldo Keto reductase
F9278_RS34920	COG0440	acetolactate synthase activity
F9278_RS34925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F9278_RS34940	COG2197	response regulator
F9278_RS34945	COG0477	Major facilitator Superfamily
F9278_RS34955	COG0515	serine threonine protein kinase
F9278_RS34955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F9278_RS34965	COG0506	proline dehydrogenase activity
F9278_RS34970	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS34985	COG0473	3-isopropylmalate dehydrogenase activity
F9278_RS34990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F9278_RS35000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F9278_RS35025	COG2353	YceI-like domain
F9278_RS35035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F9278_RS35055	COG2018	Roadblock/LC7 domain
F9278_RS35075	COG2018	Roadblock/LC7 domain
F9278_RS35080	COG5002	protein histidine kinase activity
F9278_RS35090	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS35095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F9278_RS35145	COG1414	Transcriptional regulator
F9278_RS35150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F9278_RS35155	COG0066	3-isopropylmalate dehydratase activity
F9278_RS35165	COG0776	regulation of translation
F9278_RS35175	COG1920	GTP binding
F9278_RS35185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F9278_RS35190	COG1181	Belongs to the D-alanine--D-alanine ligase family
F9278_RS35210	COG0351	phosphomethylpyrimidine kinase
F9278_RS35225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F9278_RS35230	COG1461	Dihydroxyacetone kinase
F9278_RS35240	COG0326	Molecular chaperone. Has ATPase activity
F9278_RS35250	COG0742	ribosomal rna small subunit methyltransferase
F9278_RS35255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F9278_RS35270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F9278_RS35275	COG0571	ribonuclease III activity
F9278_RS35280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F9278_RS35285	COG1733	regulation of RNA biosynthetic process
F9278_RS35290	COG2340	Cysteine-rich secretory protein family
F9278_RS35295	COG1254	Belongs to the acylphosphatase family
F9278_RS35305	COG1196	nuclear chromosome segregation
F9278_RS35310	COG0477	Major facilitator Superfamily
F9278_RS35350	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F9278_RS35365	COG0442	prolyl-tRNA aminoacylation
F9278_RS35375	COG0228	four-way junction DNA binding
F9278_RS35380	COG1837	Belongs to the UPF0109 family
F9278_RS35385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F9278_RS35390	COG0336	Belongs to the RNA methyltransferase TrmD family
F9278_RS35395	COG0335	large ribosomal subunit rRNA binding
F9278_RS35410	COG0681	Belongs to the peptidase S26 family
F9278_RS35420	COG1051	belongs to the nudix hydrolase family
F9278_RS35430	COG0792	nuclease activity
F9278_RS35445	COG1191	sigma factor activity
F9278_RS35455	COG4942	peptidase
F9278_RS35460	COG0052	Belongs to the universal ribosomal protein uS2 family
F9278_RS35465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F9278_RS35470	COG0528	UMP kinase activity
F9278_RS35475	COG0233	cytoplasmic translational termination
F9278_RS35480	COG0575	Belongs to the CDS family
F9278_RS35485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F9278_RS35495	COG4208	sulfate ABC transporter
F9278_RS35500	COG3842	ATPase activity
F9278_RS35525	COG4181	ATPase activity
F9278_RS35530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F9278_RS35540	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS35555	COG1129	ABC transporter
F9278_RS35560	COG1172	Belongs to the binding-protein-dependent transport system permease family
F9278_RS35565	COG1172	Belongs to the binding-protein-dependent transport system permease family
F9278_RS35570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F9278_RS35575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F9278_RS35580	COG1414	Transcriptional regulator
F9278_RS35590	COG2353	YceI-like domain
F9278_RS35605	COG4977	sequence-specific DNA binding
F9278_RS35620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F9278_RS35645	COG3842	ATPase activity
F9278_RS35650	COG1176	ABC-type spermidine putrescine transport system, permease component I
F9278_RS35655	COG1177	transmembrane transport
F9278_RS35660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F9278_RS35685	COG2508	Transcriptional regulator
F9278_RS35690	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS35695	COG1472	Belongs to the glycosyl hydrolase 3 family
F9278_RS35710	COG4209	transmembrane transport
F9278_RS35715	COG0395	ABC-type sugar transport system, permease component
F9278_RS35755	COG1609	Transcriptional regulator
F9278_RS35775	COG3250	beta-galactosidase activity
F9278_RS35790	COG0628	permease
F9278_RS35795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS35800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F9278_RS35815	COG5297	Belongs to the glycosyl hydrolase family 6
F9278_RS35830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F9278_RS35835	COG0750	zinc metalloprotease
F9278_RS35840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F9278_RS35855	COG0442	prolyl-tRNA aminoacylation
F9278_RS35890	COG0779	Required for maturation of 30S ribosomal subunits
F9278_RS35905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F9278_RS35915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F9278_RS35920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F9278_RS35935	COG0455	bacterial-type flagellum organization
F9278_RS35945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F9278_RS35950	COG1185	polyribonucleotide nucleotidyltransferase activity
F9278_RS35955	COG0612	Peptidase, M16
F9278_RS35960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F9278_RS35975	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F9278_RS35980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS35985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F9278_RS36020	COG2208	phosphoserine phosphatase activity
F9278_RS36020	COG2770	Histidine kinase
F9278_RS36025	COG3437	response regulator, receiver
F9278_RS36025	COG3850	Histidine kinase
F9278_RS36025	COG4999	Histidine kinase
F9278_RS36025	COG2205	protein histidine kinase activity
F9278_RS36035	COG1674	ftsk spoiiie
F9278_RS36045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F9278_RS36055	COG1546	Belongs to the CinA family
F9278_RS36055	COG1058	Belongs to the CinA family
F9278_RS36060	COG1396	sequence-specific DNA binding
F9278_RS36065	COG0783	Belongs to the Dps family
F9278_RS36375	COG4974	Belongs to the 'phage' integrase family
F9278_RS36385	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS36390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F9278_RS36395	COG1201	RNA secondary structure unwinding
F9278_RS36425	COG0628	permease
F9278_RS36430	COG1372	Participates in initiation and elongation during chromosome replication
F9278_RS36430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F9278_RS36445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F9278_RS36450	COG0765	amino acid transport
F9278_RS36455	COG0765	amino acid transport
F9278_RS36460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F9278_RS36465	COG1126	abc transporter atp-binding protein
F9278_RS36470	COG0745	RESPONSE REGULATOR receiver
F9278_RS36475	COG2205	protein histidine kinase activity
F9278_RS36530	COG1674	ftsk spoiiie
F9278_RS36535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F9278_RS36555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F9278_RS36565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F9278_RS36575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F9278_RS36585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F9278_RS36605	COG0583	DNA-binding transcription factor activity
F9278_RS36610	COG0673	inositol 2-dehydrogenase activity
F9278_RS36650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F9278_RS36655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F9278_RS36660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F9278_RS36675	COG0588	phosphoglycerate mutase activity
F9278_RS36700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F9278_RS36715	COG0514	ATP-dependent DNA helicase (RecQ)
F9278_RS36740	COG2186	Transcriptional regulator
F9278_RS36750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F9278_RS36765	COG0187	DNA topoisomerase II activity
F9278_RS36775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F9278_RS36780	COG4565	transcriptional regulatory protein
F9278_RS36785	COG3290	protein histidine kinase activity
F9278_RS36810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F9278_RS36815	COG0612	Peptidase, M16
F9278_RS36830	COG1802	Transcriptional regulator
F9278_RS36835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F9278_RS36860	COG1435	thymidine kinase activity
F9278_RS36890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F9278_RS36900	COG0745	RESPONSE REGULATOR receiver
F9278_RS36905	COG2205	protein histidine kinase activity
F9278_RS36930	COG0756	dUTP diphosphatase activity
F9278_RS36965	COG0569	domain protein
F9278_RS36970	COG0531	amino acid
F9278_RS36975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F9278_RS37000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F9278_RS37015	COG2124	cytochrome p450
F9278_RS37055	COG0745	RESPONSE REGULATOR receiver
F9278_RS37060	COG2205	protein histidine kinase activity
F9278_RS37085	COG0243	molybdopterin cofactor binding
F9278_RS37095	COG1799	cell septum assembly
F9278_RS37125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F9278_RS37130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F9278_RS37145	COG2235	arginine
F9278_RS37150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F9278_RS37160	COG1024	Enoyl-CoA hydratase
F9278_RS37185	COG0529	Catalyzes the synthesis of activated sulfate
F9278_RS37190	COG0438	transferase activity, transferring glycosyl groups
F9278_RS37255	COG0288	reversible hydration of carbon dioxide
F9278_RS37370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F9278_RS37420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F9278_RS37430	COG1404	Belongs to the peptidase S8 family
F9278_RS37470	COG1653	transport
F9278_RS37475	COG1175	transmembrane transport
F9278_RS37480	COG0395	ABC-type sugar transport system, permease component
F9278_RS37485	COG1940	carbohydrate kinase activity
F9278_RS37490	COG4213	ABC transporter substrate-binding protein
F9278_RS37500	COG4214	carbohydrate transport
F9278_RS37505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F9278_RS37510	COG0531	amino acid
F9278_RS37530	COG2319	Wd-40 repeat
F9278_RS37530	COG4249	Peptidase C14 caspase catalytic subunit p20
F9278_RS37545	COG0714	Associated with various cellular activities
F9278_RS37555	COG1316	TRANSCRIPTIONal
F9278_RS37560	COG0438	transferase activity, transferring glycosyl groups
F9278_RS37570	COG0438	transferase activity, transferring glycosyl groups
F9278_RS37575	COG0438	transferase activity, transferring glycosyl groups
F9278_RS37585	COG1250	3-hydroxyacyl-CoA dehydrogenase
F9278_RS37585	COG1024	Enoyl-CoA hydratase
F9278_RS37590	COG0183	Belongs to the thiolase family
F9278_RS37595	COG1609	Transcriptional regulator
F9278_RS37605	COG2182	Extracellular solute-binding protein
F9278_RS37610	COG1175	transmembrane transport
F9278_RS37615	COG3833	ABC-type maltose transport systems, permease component
F9278_RS37620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F9278_RS37635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F9278_RS37650	COG0446	pyridine nucleotide-disulphide oxidoreductase
F9278_RS37660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F9278_RS37665	COG3253	May function as heme-dependent peroxidase
F9278_RS37685	COG3220	belongs to the UPF0276 family
F9278_RS37715	COG0726	polysaccharide deacetylase
F9278_RS37735	COG0330	HflC and HflK could
F9278_RS37775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F9278_RS37780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F9278_RS37820	COG0443	Heat shock 70 kDa protein
F9278_RS37865	COG1335	isochorismatase
F9278_RS37875	COG3629	intracellular signal transduction
F9278_RS37875	COG3903	Transcriptional regulator
F9278_RS37880	COG3903	Transcriptional regulator
F9278_RS37880	COG3629	intracellular signal transduction
F9278_RS37905	COG1609	Transcriptional regulator
F9278_RS37930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F9278_RS37940	COG2018	Roadblock/LC7 domain
F9278_RS37950	COG1960	acyl-CoA dehydrogenase activity
F9278_RS38040	COG1404	Belongs to the peptidase S8 family
F9278_RS38060	COG0504	CTP synthase activity
F9278_RS38075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F9278_RS38085	COG3173	Aminoglycoside phosphotransferase
F9278_RS38195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS38200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F9278_RS38225	COG0529	Catalyzes the synthesis of activated sulfate
F9278_RS38230	COG0175	sulfate reduction
F9278_RS38260	COG1960	acyl-CoA dehydrogenase activity
F9278_RS38265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F9278_RS38280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F9278_RS38340	COG0395	ABC-type sugar transport system, permease component
F9278_RS38345	COG1175	transmembrane transport
F9278_RS38395	COG2040	homocysteine
F9278_RS38400	COG0531	amino acid
F9278_RS38475	COG0395	ABC-type sugar transport system, permease component
F9278_RS38480	COG1175	transmembrane transport
F9278_RS38495	COG0277	FAD linked oxidase domain protein
F9278_RS38500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F9278_RS38530	COG1162	GTPase activity
F9278_RS38540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F9278_RS38580	COG1802	Transcriptional regulator
F9278_RS38615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F9278_RS38640	COG5634	Uncharacterized conserved protein (DUF2278)
F9278_RS38665	COG2188	Transcriptional regulator
F9278_RS38670	COG3962	Belongs to the TPP enzyme family
F9278_RS38705	COG0515	serine threonine protein kinase
F9278_RS38765	COG2267	carboxylic ester hydrolase activity
F9278_RS38775	COG0657	acetylesterase activity
F9278_RS38825	COG2815	serine threonine protein kinase
F9278_RS38825	COG0515	serine threonine protein kinase
F9278_RS38830	COG0542	response to heat
F9278_RS38845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F9278_RS38845	COG2308	Evidence 4 Homologs of previously reported genes of
F9278_RS38895	COG2318	DinB family
F9278_RS38900	COG0598	Magnesium transport protein CorA
F9278_RS38930	COG2197	response regulator
F9278_RS38935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F9278_RS38940	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS38980	COG2351	hydroxyisourate hydrolase activity
F9278_RS39020	COG0588	phosphoglycerate mutase activity
F9278_RS39045	COG0436	Aminotransferase
F9278_RS39050	COG1733	regulation of RNA biosynthetic process
F9278_RS39060	COG2304	oxidoreductase activity
F9278_RS39065	COG4264	IucA IucC family
F9278_RS39095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F9278_RS39110	COG1414	Transcriptional regulator
F9278_RS39115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F9278_RS39120	COG4266	Belongs to the allantoicase family
F9278_RS39155	COG0667	Aldo Keto reductase
F9278_RS39160	COG2197	response regulator
F9278_RS39165	COG0673	inositol 2-dehydrogenase activity
F9278_RS39170	COG2188	Transcriptional regulator
F9278_RS39175	COG1940	carbohydrate kinase activity
F9278_RS39185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F9278_RS39210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F9278_RS39215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F9278_RS39235	COG1126	abc transporter atp-binding protein
F9278_RS39250	COG0405	Gamma-glutamyltransferase
F9278_RS39280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F9278_RS39295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F9278_RS39305	COG1953	Uracil, thiamine, allantoin
F9278_RS39335	COG0483	inositol monophosphate 1-phosphatase activity
F9278_RS39350	COG1082	Xylose isomerase domain protein TIM barrel
F9278_RS39380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F9278_RS39390	COG0640	Transcriptional regulator
F9278_RS39410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F9278_RS39420	COG0494	nUDIX hydrolase
F9278_RS39430	COG1929	Belongs to the glycerate kinase type-1 family
F9278_RS39440	COG0688	phosphatidylethanolamine metabolic process
F9278_RS39445	COG1960	acyl-CoA dehydrogenase activity
F9278_RS39460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS39460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS39465	COG0604	alcohol dehydrogenase
F9278_RS39475	COG1250	3-hydroxyacyl-CoA dehydrogenase
F9278_RS39490	COG0596	Alpha beta hydrolase
F9278_RS39515	COG2226	methyltransferase
F9278_RS39520	COG2362	D-Aminopeptidase
F9278_RS39525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F9278_RS39530	COG0823	Involved in the tonB-independent uptake of proteins
F9278_RS39530	COG1506	peptidase
F9278_RS39530	COG4946	Tricorn protease homolog
F9278_RS39535	COG1619	proteins homologs of microcin C7 resistance protein MccF
F9278_RS39570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F9278_RS39610	COG2226	methyltransferase
F9278_RS39620	COG0488	(ABC) transporter
F9278_RS39675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F9278_RS39700	COG0443	Heat shock 70 kDa protein
F9278_RS39725	COG2154	pterin-4-alpha-carbinolamine dehydratase
F9278_RS39730	COG2226	methyltransferase
F9278_RS39745	COG3401	FG-GAP repeat protein
F9278_RS39760	COG5297	Belongs to the glycosyl hydrolase family 6
F9278_RS39760	COG4733	cellulase activity
F9278_RS39765	COG5297	Belongs to the glycosyl hydrolase family 6
F9278_RS39775	COG4106	trans-aconitate 2-methyltransferase activity
F9278_RS39780	COG0656	L-ascorbic acid biosynthetic process
F9278_RS39815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F9278_RS39840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F9278_RS39855	COG1940	carbohydrate kinase activity
F9278_RS39860	COG1129	ABC transporter
F9278_RS39865	COG1172	Belongs to the binding-protein-dependent transport system permease family
F9278_RS39875	COG0673	inositol 2-dehydrogenase activity
F9278_RS39885	COG3507	Belongs to the glycosyl hydrolase 43 family
F9278_RS39930	COG2223	nitrite transmembrane transporter activity
F9278_RS39940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS39950	COG0045	succinate-CoA ligase (ADP-forming) activity
F9278_RS39970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F9278_RS39990	COG4249	Peptidase C14 caspase catalytic subunit p20
F9278_RS39990	COG2319	Wd-40 repeat
F9278_RS40000	COG0673	inositol 2-dehydrogenase activity
F9278_RS40005	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS40020	COG1183	phosphatidylcholine synthase activity
F9278_RS40035	COG0438	transferase activity, transferring glycosyl groups
F9278_RS40055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F9278_RS40075	COG3903	Transcriptional regulator
F9278_RS40075	COG3629	intracellular signal transduction
F9278_RS40095	COG0477	Major facilitator Superfamily
F9278_RS40115	COG0477	Major facilitator Superfamily
F9278_RS40125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F9278_RS40130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F9278_RS40130	COG1082	Xylose isomerase domain protein TIM barrel
F9278_RS40150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F9278_RS40180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F9278_RS40180	COG0515	serine threonine protein kinase
F9278_RS40190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F9278_RS40195	COG3119	arylsulfatase activity
F9278_RS40245	COG3250	beta-galactosidase activity
F9278_RS40270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F9278_RS40275	COG1349	DNA-binding transcription factor activity
F9278_RS40280	COG1486	melibiose metabolic process
F9278_RS40300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F9278_RS40350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS40355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F9278_RS40365	COG1414	Transcriptional regulator
F9278_RS40385	COG3511	phospholipase C
F9278_RS40420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F9278_RS40425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F9278_RS40430	COG3485	protocatechuate 3,4-dioxygenase
F9278_RS40435	COG3485	protocatechuate 3,4-dioxygenase
F9278_RS40440	COG0183	Belongs to the thiolase family
F9278_RS40460	COG1470	cell adhesion involved in biofilm formation
F9278_RS40470	COG1793	dna ligase
F9278_RS40505	COG0592	DNA-directed DNA polymerase activity
F9278_RS40540	COG1834	amidinotransferase
F9278_RS40545	COG0488	(ABC) transporter
F9278_RS40570	COG1515	deoxyribonuclease V activity
F9278_RS40575	COG3268	Saccharopine dehydrogenase
F9278_RS40585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS40590	COG0183	Belongs to the thiolase family
F9278_RS40595	COG1024	Enoyl-CoA hydratase
F9278_RS40595	COG1250	3-hydroxyacyl-CoA dehydrogenase
F9278_RS40625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F9278_RS40635	COG2936	dipeptidyl-peptidase activity
F9278_RS40650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F9278_RS40665	COG0488	(ABC) transporter
F9278_RS40670	COG2183	response to ionizing radiation
F9278_RS40680	COG4977	sequence-specific DNA binding
F9278_RS40690	COG1024	Enoyl-CoA hydratase
F9278_RS40705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F9278_RS40740	COG0371	Dehydrogenase
F9278_RS40760	COG1134	teichoic acid transport
F9278_RS40765	COG1562	ergosterol biosynthetic process
F9278_RS40775	COG1233	COG1233 Phytoene dehydrogenase and related
F9278_RS40785	COG1657	PFAM Prenyltransferase squalene oxidase
F9278_RS40800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F9278_RS40805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F9278_RS40825	COG2365	Tyrosine phosphatase family
F9278_RS40850	COG2755	lipolytic protein G-D-S-L family
F9278_RS40860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F9278_RS40900	COG1063	alcohol dehydrogenase
F9278_RS40905	COG0156	8-amino-7-oxononanoate synthase activity
F9278_RS40910	COG0583	DNA-binding transcription factor activity
F9278_RS40930	COG3958	Transketolase
F9278_RS40935	COG3959	Transketolase, thiamine diphosphate binding domain
F9278_RS40965	COG3938	Belongs to the proline racemase family
F9278_RS40970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS40990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F9278_RS41000	COG3387	PFAM Glycoside hydrolase 15-related
F9278_RS41005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F9278_RS41020	COG1126	abc transporter atp-binding protein
F9278_RS41025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F9278_RS41035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS41040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS41065	COG0402	S-adenosylhomocysteine deaminase activity
F9278_RS41075	COG2267	carboxylic ester hydrolase activity
F9278_RS41105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F9278_RS41115	COG1181	Belongs to the D-alanine--D-alanine ligase family
F9278_RS41155	COG3485	protocatechuate 3,4-dioxygenase
F9278_RS41160	COG1454	alcohol dehydrogenase
F9278_RS41175	COG1192	Involved in chromosome partitioning
F9278_RS41185	COG3629	intracellular signal transduction
F9278_RS41185	COG3903	Transcriptional regulator
F9278_RS41195	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F9278_RS41220	COG0667	Aldo Keto reductase
F9278_RS41225	COG1846	Transcriptional regulator
F9278_RS41235	COG2838	Isocitrate dehydrogenase
F9278_RS41240	COG0668	transmembrane transport
F9278_RS41250	COG1132	(ABC) transporter
F9278_RS41320	COG1414	Transcriptional regulator
F9278_RS41340	COG0477	Major facilitator Superfamily
F9278_RS41350	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
F9278_RS41360	COG2197	response regulator
F9278_RS41365	COG4585	Histidine kinase
F9278_RS41375	COG1131	(ABC) transporter
F9278_RS41420	COG1404	Belongs to the peptidase S8 family
F9278_RS41425	COG2319	Wd-40 repeat
F9278_RS41425	COG4249	Peptidase C14 caspase catalytic subunit p20
F9278_RS41435	COG2197	response regulator
F9278_RS41450	COG1404	Belongs to the peptidase S8 family
F9278_RS41495	COG3226	Transcriptional regulator
F9278_RS41505	COG0738	Major facilitator superfamily
F9278_RS41510	COG0535	radical SAM domain protein
F9278_RS41525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F9278_RS41550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS41555	COG1414	Transcriptional regulator
F9278_RS41560	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS41565	COG0028	Belongs to the TPP enzyme family
F9278_RS41590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F9278_RS41600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F9278_RS41605	COG0745	RESPONSE REGULATOR receiver
F9278_RS41610	COG2205	protein histidine kinase activity
F9278_RS41620	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS41625	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS41635	COG1414	Transcriptional regulator
F9278_RS41640	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS41660	COG2197	response regulator
F9278_RS41665	COG1027	Aspartate ammonia-lyase
F9278_RS41670	COG1414	Transcriptional regulator
F9278_RS41675	COG0765	amino acid transport
F9278_RS41680	COG0765	amino acid transport
F9278_RS41705	COG0596	Alpha beta hydrolase
F9278_RS41725	COG4166	transmembrane transport
F9278_RS41730	COG0601	transmembrane transport
F9278_RS41735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS41740	COG0444	Belongs to the ABC transporter superfamily
F9278_RS41745	COG4608	Belongs to the ABC transporter superfamily
F9278_RS41755	COG4948	Mandelate Racemase Muconate Lactonizing
F9278_RS41760	COG1869	D-ribose catabolic process
F9278_RS41765	COG1869	D-ribose catabolic process
F9278_RS41770	COG0596	Alpha beta hydrolase
F9278_RS41770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F9278_RS41775	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS41795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F9278_RS41820	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS41825	COG0183	Belongs to the thiolase family
F9278_RS41840	COG1960	acyl-CoA dehydrogenase activity
F9278_RS41845	COG1960	acyl-CoA dehydrogenase activity
F9278_RS41865	COG0657	acetylesterase activity
F9278_RS41870	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS41875	COG0579	oxidoreductase
F9278_RS41905	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F9278_RS41915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F9278_RS41945	COG0596	Alpha beta hydrolase
F9278_RS41950	COG2072	flavoprotein involved in K transport
F9278_RS41985	COG2211	Major facilitator Superfamily
F9278_RS42000	COG1309	transcriptional regulator
F9278_RS42035	COG2124	cytochrome p450
F9278_RS42050	COG4221	oxidoreductase activity
F9278_RS42085	COG2124	cytochrome p450
F9278_RS42095	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS42105	COG2267	carboxylic ester hydrolase activity
F9278_RS42120	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS42135	COG0583	DNA-binding transcription factor activity
F9278_RS42140	COG0183	Belongs to the thiolase family
F9278_RS42150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F9278_RS42175	COG3485	protocatechuate 3,4-dioxygenase
F9278_RS42185	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS42205	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS42215	COG4249	Peptidase C14 caspase catalytic subunit p20
F9278_RS42215	COG2319	Wd-40 repeat
F9278_RS42245	COG1175	transmembrane transport
F9278_RS42255	COG1472	Belongs to the glycosyl hydrolase 3 family
F9278_RS42265	COG1609	Transcriptional regulator
F9278_RS42305	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS42310	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS42315	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS42320	COG1414	Transcriptional regulator
F9278_RS42330	COG0179	Fumarylacetoacetate (FAA) hydrolase
F9278_RS42340	COG1378	Sugar-specific transcriptional regulator TrmB
F9278_RS42345	COG3693	PFAM glycoside hydrolase, family 10
F9278_RS42345	COG2382	esterase
F9278_RS42345	COG3507	Belongs to the glycosyl hydrolase 43 family
F9278_RS42365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F9278_RS42380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F9278_RS42400	COG0297	glycogen (starch) synthase activity
F9278_RS42405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F9278_RS42455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F9278_RS42480	COG0726	polysaccharide deacetylase
F9278_RS42535	COG1053	succinate dehydrogenase
F9278_RS42540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F9278_RS42560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS42575	COG1477	protein flavinylation
F9278_RS42590	COG0745	RESPONSE REGULATOR receiver
F9278_RS42595	COG2205	protein histidine kinase activity
F9278_RS42610	COG0745	RESPONSE REGULATOR receiver
F9278_RS42635	COG2072	flavoprotein involved in K transport
F9278_RS42655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F9278_RS42660	COG2271	Major facilitator Superfamily
F9278_RS42665	COG0657	acetylesterase activity
F9278_RS42685	COG3360	Dodecin
F9278_RS42690	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F9278_RS42695	COG0121	glutamine amidotransferase
F9278_RS42700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F9278_RS42705	COG3572	ergothioneine biosynthetic process
F9278_RS42720	COG2268	Band 7 protein
F9278_RS42735	COG1609	Transcriptional regulator
F9278_RS42745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F9278_RS42755	COG0242	peptide deformylase activity
F9278_RS42790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F9278_RS42845	COG1120	ATPase activity
F9278_RS42875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS42880	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F9278_RS42890	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F9278_RS42910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F9278_RS42940	COG3708	Transcriptional regulator
F9278_RS42940	COG2207	Transcriptional regulator
F9278_RS42945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F9278_RS42985	COG1556	Lactate utilization protein
F9278_RS42990	COG1139	Iron-sulfur cluster binding protein
F9278_RS42995	COG0247	lactate metabolic process
F9278_RS43000	COG1070	Carbohydrate kinase
F9278_RS43005	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS43005	COG3347	Dehydrogenase
F9278_RS43015	COG1129	ABC transporter
F9278_RS43045	COG1609	Transcriptional regulator
F9278_RS43065	COG1357	PFAM Pentapeptide repeats (8 copies)
F9278_RS43075	COG1309	transcriptional regulator
F9278_RS43085	COG2706	6-phosphogluconolactonase activity
F9278_RS43120	COG1796	DNA polymerase
F9278_RS43120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F9278_RS43140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F9278_RS43155	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS43195	COG0435	Glutathione S-transferase
F9278_RS43215	COG1846	Transcriptional regulator
F9278_RS43230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F9278_RS43260	COG2197	response regulator
F9278_RS43270	COG2207	Transcriptional regulator
F9278_RS43300	COG3250	beta-galactosidase activity
F9278_RS43355	COG0248	Ppx GppA phosphatase
F9278_RS43365	COG0747	negative chemotaxis
F9278_RS43370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F9278_RS43410	COG0515	serine threonine protein kinase
F9278_RS43425	COG3608	succinylglutamate desuccinylase aspartoacylase
F9278_RS43425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F9278_RS43440	COG1819	glycosyl
F9278_RS43445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F9278_RS43470	COG1132	(ABC) transporter
F9278_RS43480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F9278_RS43490	COG3958	Transketolase
F9278_RS43500	COG1937	Protein conserved in bacteria
F9278_RS43575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F9278_RS43590	COG2182	Extracellular solute-binding protein
F9278_RS43595	COG0395	ABC-type sugar transport system, permease component
F9278_RS43600	COG1175	transmembrane transport
F9278_RS43605	COG1940	carbohydrate kinase activity
F9278_RS43605	COG1846	Transcriptional regulator
F9278_RS43640	COG2197	response regulator
F9278_RS43665	COG1940	carbohydrate kinase activity
F9278_RS43680	COG0395	ABC-type sugar transport system, permease component
F9278_RS43695	COG0572	uridine kinase
F9278_RS43710	COG2340	Cysteine-rich secretory protein family
F9278_RS43750	COG1228	amidohydrolase
F9278_RS43780	COG0492	ferredoxin-NADP+ reductase activity
F9278_RS43825	COG3290	protein histidine kinase activity
F9278_RS43830	COG4565	transcriptional regulatory protein
F9278_RS43845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F9278_RS43875	COG0009	L-threonylcarbamoyladenylate synthase
F9278_RS43910	COG0673	inositol 2-dehydrogenase activity
F9278_RS43915	COG3290	protein histidine kinase activity
F9278_RS43925	COG4585	Histidine kinase
F9278_RS43930	COG2197	response regulator
F9278_RS43960	COG2409	Drug exporters of the RND superfamily
F9278_RS44020	COG0395	ABC-type sugar transport system, permease component
F9278_RS44030	COG1653	transport
F9278_RS44045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F9278_RS44055	COG1024	Enoyl-CoA hydratase
F9278_RS44065	COG0181	hydroxymethylbilane synthase activity
F9278_RS44125	COG0513	Belongs to the DEAD box helicase family
F9278_RS44165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F9278_RS44170	COG1960	acyl-CoA dehydrogenase activity
F9278_RS44185	COG2226	methyltransferase
F9278_RS44190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F9278_RS44195	COG1653	transport
F9278_RS44200	COG1175	transmembrane transport
F9278_RS44205	COG0395	ABC-type sugar transport system, permease component
F9278_RS44225	COG0187	DNA topoisomerase II activity
F9278_RS44230	COG3655	Transcriptional regulator
F9278_RS44265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F9278_RS44290	COG0789	Transcriptional regulator
F9278_RS44310	COG1131	(ABC) transporter
F9278_RS44325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS44400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F9278_RS44410	COG1414	Transcriptional regulator
F9278_RS44415	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F9278_RS44425	COG1012	belongs to the aldehyde dehydrogenase family
F9278_RS44430	COG0517	IMP dehydrogenase activity
F9278_RS44430	COG4175	Glycine betaine
F9278_RS44470	COG2197	response regulator
F9278_RS44490	COG2326	polyphosphate kinase activity
F9278_RS44505	COG5640	endopeptidase activity
F9278_RS44510	COG2326	polyphosphate kinase activity
F9278_RS44570	COG1703	isobutyryl-CoA mutase activity
F9278_RS44570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS44570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F9278_RS44595	COG1595	DNA-templated transcription, initiation
F9278_RS44630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F9278_RS44680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F9278_RS44685	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F9278_RS44690	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F9278_RS44705	COG2197	response regulator
F9278_RS44710	COG3851	Histidine kinase
F9278_RS44770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F9278_RS44815	COG2755	lipolytic protein G-D-S-L family
F9278_RS44865	COG1335	isochorismatase
F9278_RS44875	COG0723	plastoquinol--plastocyanin reductase activity
F9278_RS44875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F9278_RS44940	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS44970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F9278_RS44985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F9278_RS45000	COG1595	DNA-templated transcription, initiation
F9278_RS45015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F9278_RS45020	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS45030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F9278_RS45045	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS45050	COG1960	acyl-CoA dehydrogenase activity
F9278_RS45060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F9278_RS45060	COG3320	Male sterility
F9278_RS45075	COG2175	clavaminate synthase activity
F9278_RS45080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F9278_RS45085	COG0667	Aldo Keto reductase
F9278_RS45105	COG2124	cytochrome p450
F9278_RS45140	COG0326	Molecular chaperone. Has ATPase activity
F9278_RS45155	COG1021	2,3-dihydroxybenzoate-AMP ligase
F9278_RS45175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F9278_RS45185	COG1053	succinate dehydrogenase
F9278_RS45220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F9278_RS45230	COG1535	isochorismatase
F9278_RS45230	COG3433	isochorismatase activity
F9278_RS45235	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F9278_RS45240	COG1132	(ABC) transporter
F9278_RS45250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F9278_RS45270	COG1132	(ABC) transporter
F9278_RS45280	COG0473	3-isopropylmalate dehydrogenase activity
F9278_RS45305	COG0673	inositol 2-dehydrogenase activity
F9278_RS45310	COG1609	Transcriptional regulator
F9278_RS45340	COG0583	DNA-binding transcription factor activity
F9278_RS45355	COG1252	NADH dehydrogenase
F9278_RS45360	COG1595	DNA-templated transcription, initiation
F9278_RS45390	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS45435	COG0154	amidase activity
F9278_RS45480	COG3629	intracellular signal transduction
F9278_RS45480	COG3903	Transcriptional regulator
F9278_RS45490	COG1609	Transcriptional regulator
F9278_RS45540	COG0604	alcohol dehydrogenase
F9278_RS45540	COG1028	Short-chain dehydrogenase reductase Sdr
F9278_RS45540	COG3321	synthase
F9278_RS45560	COG2267	carboxylic ester hydrolase activity
F9278_RS45575	COG2146	nitrite reductase [NAD(P)H] activity
F9278_RS45600	COG0559	Belongs to the binding-protein-dependent transport system permease family
F9278_RS45610	COG1414	Transcriptional regulator
F9278_RS45625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F9278_RS45640	COG0477	Major facilitator Superfamily
F9278_RS45655	COG0318	PFAM AMP-dependent synthetase and ligase
F9278_RS45665	COG2223	nitrite transmembrane transporter activity
F9278_RS45680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F9278_RS45685	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F9278_RS45695	COG0243	molybdopterin cofactor binding
F9278_RS45700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F9278_RS45705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F9278_RS45705	COG2146	nitrite reductase [NAD(P)H] activity
F9278_RS45780	COG1695	Transcriptional regulator
F9278_RS45815	COG2226	methyltransferase
F9278_RS45820	COG0640	Transcriptional regulator
F9278_RS45830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F9278_RS45840	COG1621	beta-fructofuranosidase activity
F9278_RS45865	COG1609	Transcriptional regulator
F9278_RS45935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS45940	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F9278_RS45960	COG3328	transposase activity
F9278_RS45990	COG0497	DNA recombination