locus-tag	class	description
C1703_RS00015	COG2197	response regulator
C1703_RS00020	COG2409	Drug exporters of the RND superfamily
C1703_RS00045	COG1695	Transcriptional regulator
C1703_RS00065	COG1733	regulation of RNA biosynthetic process
C1703_RS00085	COG1846	Transcriptional regulator
C1703_RS00130	COG1024	Enoyl-CoA hydratase
C1703_RS00135	COG0574	Belongs to the PEP-utilizing enzyme family
C1703_RS00135	COG3848	Pyruvate phosphate dikinase
C1703_RS00140	COG3265	gluconokinase activity
C1703_RS00145	COG1063	alcohol dehydrogenase
C1703_RS00150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1703_RS00165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1703_RS00180	COG2197	response regulator
C1703_RS00185	COG3851	Histidine kinase
C1703_RS00195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1703_RS00205	COG0745	RESPONSE REGULATOR receiver
C1703_RS00210	COG2205	protein histidine kinase activity
C1703_RS00215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1703_RS00255	COG1819	glycosyl
C1703_RS00265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1703_RS00265	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C1703_RS00280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1703_RS00315	COG1090	epimerase
C1703_RS00395	COG3397	chitin binding
C1703_RS00400	COG0456	acetyltransferase
C1703_RS00405	COG1295	ribonuclease BN
C1703_RS00465	COG3540	Alkaline phosphatase
C1703_RS00500	COG1982	Orn Lys Arg decarboxylase major
C1703_RS00525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1703_RS00525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1703_RS00530	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1703_RS00535	COG0438	transferase activity, transferring glycosyl groups
C1703_RS00545	COG0859	PFAM glycosyl transferase family 9
C1703_RS00560	COG2192	nodulation
C1703_RS00565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1703_RS00595	COG0753	catalase activity
C1703_RS00645	COG0009	L-threonylcarbamoyladenylate synthase
C1703_RS00675	COG1621	beta-fructofuranosidase activity
C1703_RS00685	COG1175	transmembrane transport
C1703_RS00690	COG0395	ABC-type sugar transport system, permease component
C1703_RS00700	COG1609	Transcriptional regulator
C1703_RS00735	COG2207	Transcriptional regulator
C1703_RS00740	COG2223	nitrite transmembrane transporter activity
C1703_RS00750	COG1793	dna ligase
C1703_RS00750	COG3285	dna ligase
C1703_RS00765	COG0181	hydroxymethylbilane synthase activity
C1703_RS00785	COG1846	Transcriptional regulator
C1703_RS00820	COG0366	Alpha amylase catalytic
C1703_RS00835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1703_RS00840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1703_RS00870	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS00875	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS00880	COG2172	sigma factor antagonist activity
C1703_RS00900	COG1252	NADH dehydrogenase
C1703_RS00945	COG1982	Orn Lys Arg decarboxylase major
C1703_RS01010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1703_RS01035	COG3852	Histidine kinase
C1703_RS01045	COG1672	PFAM Archaeal ATPase
C1703_RS01045	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1703_RS01055	COG2340	Cysteine-rich secretory protein family
C1703_RS01075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1703_RS01080	COG0515	serine threonine protein kinase
C1703_RS01090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS01120	COG0667	Aldo Keto reductase
C1703_RS01135	COG0477	Major facilitator Superfamily
C1703_RS01155	COG0328	RNA-DNA hybrid ribonuclease activity
C1703_RS01165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1703_RS01190	COG0740	serine-type endopeptidase activity
C1703_RS01195	COG0740	serine-type endopeptidase activity
C1703_RS01200	COG1396	sequence-specific DNA binding
C1703_RS01205	COG1191	sigma factor activity
C1703_RS01250	COG1131	(ABC) transporter
C1703_RS01250	COG0842	Transport permease protein
C1703_RS01250	COG1716	ATPase activity
C1703_RS01270	COG0667	Aldo Keto reductase
C1703_RS01275	COG0583	DNA-binding transcription factor activity
C1703_RS01285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1703_RS01290	COG0346	lactoylglutathione lyase activity
C1703_RS01310	COG0667	Aldo Keto reductase
C1703_RS01350	COG0431	NADPH-dependent FMN reductase
C1703_RS01430	COG0589	response to stress
C1703_RS01455	COG1024	Enoyl-CoA hydratase
C1703_RS01480	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS01485	COG2366	antibiotic biosynthetic process
C1703_RS01500	COG2070	2-Nitropropane dioxygenase
C1703_RS01505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1703_RS01535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS01540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1703_RS01550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS01555	COG1177	transmembrane transport
C1703_RS01565	COG3842	ATPase activity
C1703_RS01580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS01635	COG1840	ABC-type Fe3 transport system, periplasmic component
C1703_RS01640	COG3290	protein histidine kinase activity
C1703_RS01655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1703_RS01665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1703_RS01670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C1703_RS01715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1703_RS01720	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1703_RS01725	COG0673	inositol 2-dehydrogenase activity
C1703_RS01750	COG1960	acyl-CoA dehydrogenase activity
C1703_RS01800	COG0514	ATP-dependent DNA helicase (RecQ)
C1703_RS01815	COG1309	transcriptional regulator
C1703_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS01825	COG0640	Transcriptional regulator
C1703_RS01870	COG0745	RESPONSE REGULATOR receiver
C1703_RS01875	COG2205	protein histidine kinase activity
C1703_RS01880	COG1316	TRANSCRIPTIONal
C1703_RS01885	COG2755	lipolytic protein G-D-S-L family
C1703_RS01885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1703_RS01895	COG2376	Dihydroxyacetone kinase
C1703_RS01900	COG1461	Dihydroxyacetone kinase
C1703_RS01905	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C1703_RS01935	COG1902	pentaerythritol trinitrate reductase activity
C1703_RS01935	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1703_RS01950	COG2890	protein-(glutamine-N5) methyltransferase activity
C1703_RS01960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1703_RS01975	COG3458	cephalosporin-C deacetylase activity
C1703_RS01980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1703_RS01985	COG2188	Transcriptional regulator
C1703_RS01990	COG2207	Transcriptional regulator
C1703_RS02005	COG2226	methyltransferase
C1703_RS02015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1703_RS02020	COG1686	Belongs to the peptidase S11 family
C1703_RS02035	COG2066	Belongs to the glutaminase family
C1703_RS02050	COG1113	amino acid transport
C1703_RS02055	COG2186	Transcriptional regulator
C1703_RS02060	COG1968	undecaprenyl-diphosphatase activity
C1703_RS02065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1703_RS02070	COG1993	acr, cog1993
C1703_RS02075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1703_RS02100	COG1653	transport
C1703_RS02105	COG1175	transmembrane transport
C1703_RS02110	COG0395	ABC-type sugar transport system, permease component
C1703_RS02130	COG3340	Belongs to the peptidase S51 family
C1703_RS02155	COG1609	Transcriptional regulator
C1703_RS02165	COG0723	plastoquinol--plastocyanin reductase activity
C1703_RS02165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS02175	COG0667	Aldo Keto reductase
C1703_RS02180	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS02190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1703_RS02205	COG3842	ATPase activity
C1703_RS02235	COG1414	Transcriptional regulator
C1703_RS02240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1703_RS02250	COG0247	lactate metabolic process
C1703_RS02250	COG0277	FAD linked oxidase domain protein
C1703_RS02255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1703_RS02265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1703_RS02270	COG2151	metal-sulfur cluster biosynthetic enzyme
C1703_RS02275	COG3396	Phenylacetate-CoA oxygenase
C1703_RS02280	COG3460	Phenylacetate-CoA oxygenase
C1703_RS02285	COG3396	Phenylacetate-CoA oxygenase
C1703_RS02290	COG2050	protein possibly involved in aromatic compounds catabolism
C1703_RS02310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1703_RS02310	COG1024	Enoyl-CoA hydratase
C1703_RS02315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1703_RS02335	COG0281	malic enzyme
C1703_RS02360	COG1660	Displays ATPase and GTPase activities
C1703_RS02375	COG0488	(ABC) transporter
C1703_RS02380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1703_RS02395	COG1191	sigma factor activity
C1703_RS02410	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS02415	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS02420	COG2172	sigma factor antagonist activity
C1703_RS02440	COG2186	Transcriptional regulator
C1703_RS02460	COG0251	oxidation-reduction process
C1703_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS02480	COG3842	ATPase activity
C1703_RS02490	COG1177	transmembrane transport
C1703_RS02495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS02640	COG4948	Mandelate Racemase Muconate Lactonizing
C1703_RS02645	COG0395	ABC-type sugar transport system, permease component
C1703_RS02680	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1703_RS02685	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1703_RS02690	COG1129	ABC transporter
C1703_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS02760	COG1215	transferase activity, transferring glycosyl groups
C1703_RS02795	COG1349	DNA-binding transcription factor activity
C1703_RS02845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1703_RS02850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1703_RS02865	COG1940	carbohydrate kinase activity
C1703_RS02875	COG2813	Specifically methylates the guanine in position
C1703_RS02885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1703_RS02895	COG3387	PFAM Glycoside hydrolase 15-related
C1703_RS02915	COG4106	trans-aconitate 2-methyltransferase activity
C1703_RS02920	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C1703_RS02940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1703_RS02950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1703_RS02960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1703_RS02975	COG1169	isochorismate synthase
C1703_RS02980	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1703_RS02985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1703_RS02990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1703_RS03005	COG0395	ABC-type sugar transport system, permease component
C1703_RS03010	COG1175	transmembrane transport
C1703_RS03055	COG1231	oxidoreductase activity
C1703_RS03080	COG1609	Transcriptional regulator
C1703_RS03090	COG0395	ABC-type sugar transport system, permease component
C1703_RS03095	COG4209	transmembrane transport
C1703_RS03105	COG0672	)-iron permease
C1703_RS03120	COG3594	Acyltransferase
C1703_RS03170	COG1175	transmembrane transport
C1703_RS03190	COG4326	sporulation control protein
C1703_RS03220	COG0326	Molecular chaperone. Has ATPase activity
C1703_RS03250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1703_RS03255	COG0475	glutathione-regulated potassium exporter activity
C1703_RS03265	COG2814	Major facilitator Superfamily
C1703_RS03295	COG0789	Transcriptional regulator
C1703_RS03300	COG4106	trans-aconitate 2-methyltransferase activity
C1703_RS03300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1703_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS03370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1703_RS03405	COG3293	Transposase
C1703_RS03415	COG2197	response regulator
C1703_RS03420	COG4585	Histidine kinase
C1703_RS03455	COG4608	Belongs to the ABC transporter superfamily
C1703_RS03465	COG0601	transmembrane transport
C1703_RS03470	COG0747	negative chemotaxis
C1703_RS03475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS03480	COG1660	Displays ATPase and GTPase activities
C1703_RS03500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1703_RS03535	COG0515	serine threonine protein kinase
C1703_RS03535	COG2815	serine threonine protein kinase
C1703_RS03550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C1703_RS03575	COG0204	Acyl-transferase
C1703_RS03605	COG0584	glycerophosphoryl diester phosphodiesterase
C1703_RS03635	COG1846	Transcriptional regulator
C1703_RS03655	COG0671	phosphoesterase, PA-phosphatase related
C1703_RS03665	COG1309	transcriptional regulator
C1703_RS03680	COG0640	Transcriptional regulator
C1703_RS03685	COG1902	pentaerythritol trinitrate reductase activity
C1703_RS03690	COG3509	depolymerase
C1703_RS03715	COG1960	acyl-CoA dehydrogenase activity
C1703_RS03735	COG1653	transport
C1703_RS03740	COG1175	transmembrane transport
C1703_RS03745	COG0395	ABC-type sugar transport system, permease component
C1703_RS03760	COG1609	Transcriptional regulator
C1703_RS03765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1703_RS03780	COG2706	6-phosphogluconolactonase activity
C1703_RS03795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1703_RS03820	COG1653	transport
C1703_RS03825	COG1175	transmembrane transport
C1703_RS03830	COG0395	ABC-type sugar transport system, permease component
C1703_RS03835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS03840	COG4948	Mandelate Racemase Muconate Lactonizing
C1703_RS03860	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS03885	COG3693	PFAM glycoside hydrolase, family 10
C1703_RS03890	COG1408	metallophosphoesterase
C1703_RS03915	COG1131	(ABC) transporter
C1703_RS03965	COG1132	(ABC) transporter
C1703_RS03975	COG0308	aminopeptidase N
C1703_RS03985	COG2207	Transcriptional regulator
C1703_RS03985	COG3708	Transcriptional regulator
C1703_RS04025	COG1609	Transcriptional regulator
C1703_RS04030	COG0583	DNA-binding transcription factor activity
C1703_RS04035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1703_RS04050	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1703_RS04055	COG1960	acyl-CoA dehydrogenase activity
C1703_RS04060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS04075	COG0477	Major facilitator Superfamily
C1703_RS04105	COG1522	sequence-specific DNA binding
C1703_RS04110	COG1280	lysine exporter protein (LysE YggA)
C1703_RS04135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1703_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS04175	COG2226	methyltransferase
C1703_RS04175	COG2267	carboxylic ester hydrolase activity
C1703_RS04180	COG1309	transcriptional regulator
C1703_RS04205	COG2124	cytochrome p450
C1703_RS04235	COG2201	protein-glutamate methylesterase activity
C1703_RS04250	COG1132	(ABC) transporter
C1703_RS04260	COG0515	serine threonine protein kinase
C1703_RS04280	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1703_RS04285	COG1129	ABC transporter
C1703_RS04300	COG0432	Pfam Uncharacterised protein family UPF0047
C1703_RS04305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1703_RS04310	COG1116	anion transmembrane transporter activity
C1703_RS04320	COG2072	flavoprotein involved in K transport
C1703_RS04330	COG1132	(ABC) transporter
C1703_RS04355	COG1132	(ABC) transporter
C1703_RS04365	COG0254	rRNA binding
C1703_RS04380	COG1946	Acyl-CoA thioesterase
C1703_RS04390	COG2267	carboxylic ester hydrolase activity
C1703_RS04415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1703_RS04430	COG2018	Roadblock/LC7 domain
C1703_RS04490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1703_RS04515	COG1940	carbohydrate kinase activity
C1703_RS04530	COG1051	belongs to the nudix hydrolase family
C1703_RS04550	COG1960	acyl-CoA dehydrogenase activity
C1703_RS04555	COG1960	acyl-CoA dehydrogenase activity
C1703_RS04565	COG1396	sequence-specific DNA binding
C1703_RS04565	COG3800	Transcriptional regulator
C1703_RS04570	COG3634	alkyl hydroperoxide reductase activity
C1703_RS04575	COG1793	dna ligase
C1703_RS04585	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS04600	COG3424	synthase
C1703_RS04605	COG2124	cytochrome p450
C1703_RS04620	COG1960	acyl-CoA dehydrogenase activity
C1703_RS04630	COG0242	peptide deformylase activity
C1703_RS04640	COG3442	glutamine amidotransferase
C1703_RS04645	COG0205	6-phosphofructokinase activity
C1703_RS04660	COG0515	serine threonine protein kinase
C1703_RS04660	COG2815	serine threonine protein kinase
C1703_RS04670	COG3275	phosphorelay sensor kinase activity
C1703_RS04675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1703_RS04685	COG3279	Response regulator of the LytR AlgR family
C1703_RS04690	COG1522	sequence-specific DNA binding
C1703_RS04695	COG1834	amidinotransferase
C1703_RS04700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1703_RS04720	COG0204	Acyl-transferase
C1703_RS04735	COG0829	nickel cation binding
C1703_RS04740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1703_RS04750	COG0804	urea catabolic process
C1703_RS04755	COG0832	Belongs to the urease beta subunit family
C1703_RS04760	COG0831	urea catabolic process
C1703_RS04765	COG1309	transcriptional regulator
C1703_RS04780	COG0740	serine-type endopeptidase activity
C1703_RS04820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1703_RS04825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1703_RS04830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1703_RS04840	COG2226	methyltransferase
C1703_RS04855	COG1136	(ABC) transporter
C1703_RS04855	COG0577	efflux transmembrane transporter activity
C1703_RS04860	COG0577	efflux transmembrane transporter activity
C1703_RS04860	COG1136	(ABC) transporter
C1703_RS04870	COG0456	acetyltransferase
C1703_RS04905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1703_RS04910	COG3663	DNA glycosylase
C1703_RS04935	COG2197	response regulator
C1703_RS04940	COG1940	carbohydrate kinase activity
C1703_RS04945	COG2188	Transcriptional regulator
C1703_RS04950	COG1595	DNA-templated transcription, initiation
C1703_RS04965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1703_RS04980	COG0626	cystathionine gamma-synthase activity
C1703_RS04995	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS05010	COG1522	sequence-specific DNA binding
C1703_RS05015	COG0419	ATPase involved in DNA repair
C1703_RS05020	COG0420	3'-5' exonuclease activity
C1703_RS05030	COG1132	(ABC) transporter
C1703_RS05035	COG1132	(ABC) transporter
C1703_RS05040	COG1120	ATPase activity
C1703_RS05045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1703_RS05075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1703_RS05080	COG1121	(ABC) transporter
C1703_RS05085	COG1739	Uncharacterized protein family UPF0029
C1703_RS05100	COG1120	ATPase activity
C1703_RS05105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1703_RS05115	COG1832	CoA-binding protein
C1703_RS05120	COG0531	amino acid
C1703_RS05130	COG0640	Transcriptional regulator
C1703_RS05155	COG0110	maltose O-acetyltransferase activity
C1703_RS05175	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C1703_RS05190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1703_RS05210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1703_RS05220	COG0183	Belongs to the thiolase family
C1703_RS05230	COG1968	undecaprenyl-diphosphatase activity
C1703_RS05250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1703_RS05255	COG0673	inositol 2-dehydrogenase activity
C1703_RS05270	COG2318	DinB family
C1703_RS05285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1703_RS05290	COG0747	negative chemotaxis
C1703_RS05335	COG0697	spore germination
C1703_RS05390	COG0384	phenazine biosynthesis protein PhzF
C1703_RS05415	COG1609	Transcriptional regulator
C1703_RS05425	COG0395	ABC-type sugar transport system, permease component
C1703_RS05430	COG1175	transmembrane transport
C1703_RS05475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1703_RS05475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1703_RS05485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1703_RS05505	COG1716	ATPase activity
C1703_RS05525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1703_RS05560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1703_RS05570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1703_RS05590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1703_RS05600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1703_RS05605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1703_RS05625	COG2018	Roadblock/LC7 domain
C1703_RS05640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1703_RS05645	COG2146	nitrite reductase [NAD(P)H] activity
C1703_RS05650	COG1414	Transcriptional regulator
C1703_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS05680	COG0531	amino acid
C1703_RS05710	COG2814	Major facilitator Superfamily
C1703_RS05715	COG4336	lyase activity
C1703_RS05720	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1703_RS05725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1703_RS05730	COG1984	allophanate hydrolase subunit 2
C1703_RS05735	COG2755	lipolytic protein G-D-S-L family
C1703_RS05740	COG0438	transferase activity, transferring glycosyl groups
C1703_RS05780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1703_RS05785	COG2364	Membrane
C1703_RS05795	COG2270	Major facilitator Superfamily
C1703_RS05835	COG1960	acyl-CoA dehydrogenase activity
C1703_RS05885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1703_RS05890	COG0140	phosphoribosyl-ATP diphosphatase activity
C1703_RS05895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1703_RS05900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1703_RS05900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1703_RS05905	COG3201	nicotinamide mononucleotide transporter
C1703_RS05915	COG1940	carbohydrate kinase activity
C1703_RS05915	COG1846	Transcriptional regulator
C1703_RS05920	COG0738	Major facilitator superfamily
C1703_RS05925	COG2233	PERMEase
C1703_RS05950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1703_RS05975	COG0531	amino acid
C1703_RS05980	COG0517	IMP dehydrogenase activity
C1703_RS05980	COG0516	GMP reductase activity
C1703_RS05990	COG2390	Transcriptional regulator
C1703_RS05995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1703_RS06000	COG2409	Drug exporters of the RND superfamily
C1703_RS06010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1703_RS06025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1703_RS06035	COG1758	RNA polymerase activity
C1703_RS06040	COG0194	GDP metabolic process
C1703_RS06050	COG0284	orotidine-5'-phosphate decarboxylase activity
C1703_RS06055	COG0167	dihydroorotate dehydrogenase activity
C1703_RS06060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1703_RS06065	COG0505	Belongs to the CarA family
C1703_RS06075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1703_RS06080	COG0540	Belongs to the ATCase OTCase family
C1703_RS06085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1703_RS06095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1703_RS06100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1703_RS06105	COG0006	proline dipeptidase activity
C1703_RS06115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1703_RS06120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1703_RS06125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1703_RS06130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1703_RS06140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1703_RS06145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1703_RS06160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1703_RS06190	COG2197	response regulator
C1703_RS06195	COG0124	histidyl-tRNA synthetase
C1703_RS06205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1703_RS06210	COG1196	nuclear chromosome segregation
C1703_RS06215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1703_RS06225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1703_RS06230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1703_RS06235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1703_RS06245	COG2255	four-way junction helicase activity
C1703_RS06250	COG0632	four-way junction helicase activity
C1703_RS06255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1703_RS06260	COG0217	transcriptional regulatory protein
C1703_RS06265	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C1703_RS06270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C1703_RS06300	COG0438	transferase activity, transferring glycosyl groups
C1703_RS06305	COG1560	Kdo2-lipid A biosynthetic process
C1703_RS06310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1703_RS06330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1703_RS06345	COG5002	protein histidine kinase activity
C1703_RS06345	COG2176	DNA-directed DNA polymerase activity
C1703_RS06375	COG0395	ABC-type sugar transport system, permease component
C1703_RS06380	COG1175	transmembrane transport
C1703_RS06435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1703_RS06490	COG2816	NAD+ diphosphatase activity
C1703_RS06500	COG1648	precorrin-2 dehydrogenase activity
C1703_RS06500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1703_RS06505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1703_RS06520	COG1464	Belongs to the NlpA lipoprotein family
C1703_RS06525	COG2011	ABC-type metal ion transport system permease component
C1703_RS06530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1703_RS06560	COG0584	glycerophosphoryl diester phosphodiesterase
C1703_RS06565	COG0204	Acyl-transferase
C1703_RS06565	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS06570	COG0477	Major facilitator Superfamily
C1703_RS06590	COG0165	Argininosuccinate lyase
C1703_RS06610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1703_RS06610	COG1017	nitric oxide dioxygenase activity
C1703_RS06625	COG1438	arginine binding
C1703_RS06630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1703_RS06635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1703_RS06640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1703_RS06645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1703_RS06675	COG0697	spore germination
C1703_RS06685	COG1649	PFAM Uncharacterised BCR, COG1649
C1703_RS06720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1703_RS06720	COG0072	phenylalanine-tRNA ligase activity
C1703_RS06725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1703_RS06730	COG5002	protein histidine kinase activity
C1703_RS06735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1703_RS06740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1703_RS06745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1703_RS06750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1703_RS06790	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS06805	COG0531	amino acid
C1703_RS06810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1703_RS06835	COG4176	ABC-type proline glycine betaine transport system permease component
C1703_RS06840	COG4175	Glycine betaine
C1703_RS06840	COG0517	IMP dehydrogenase activity
C1703_RS06845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1703_RS06900	COG0805	protein transport
C1703_RS06905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1703_RS06925	COG2378	regulation of single-species biofilm formation
C1703_RS06935	COG0545	Peptidyl-prolyl cis-trans isomerase
C1703_RS06940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1703_RS06950	COG1609	Transcriptional regulator
C1703_RS06955	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1703_RS06960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1703_RS06975	COG4122	O-methyltransferase activity
C1703_RS06980	COG1222	aaa ATPase
C1703_RS07005	COG0517	IMP dehydrogenase activity
C1703_RS07005	COG1994	Peptidase M50
C1703_RS07015	COG2197	response regulator
C1703_RS07020	COG0747	negative chemotaxis
C1703_RS07025	COG4166	transmembrane transport
C1703_RS07030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1703_RS07035	COG1410	methionine synthase
C1703_RS07035	COG0646	methionine synthase
C1703_RS07040	COG1414	Transcriptional regulator
C1703_RS07045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1703_RS07050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1703_RS07055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1703_RS07060	COG2186	Transcriptional regulator
C1703_RS07070	COG0215	cysteine-tRNA ligase activity
C1703_RS07085	COG0588	phosphoglycerate mutase activity
C1703_RS07090	COG0598	Magnesium transport protein CorA
C1703_RS07100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS07105	COG0667	Aldo Keto reductase
C1703_RS07145	COG3012	SEC-C Motif Domain Protein
C1703_RS07150	COG2186	Transcriptional regulator
C1703_RS07155	COG3265	gluconokinase activity
C1703_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS07170	COG1063	alcohol dehydrogenase
C1703_RS07200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1703_RS07205	COG2149	membrane
C1703_RS07235	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS07245	COG3876	Protein conserved in bacteria
C1703_RS07270	COG0789	Transcriptional regulator
C1703_RS07290	COG1960	acyl-CoA dehydrogenase activity
C1703_RS07300	COG0640	Transcriptional regulator
C1703_RS07305	COG0697	spore germination
C1703_RS07310	COG0477	Major facilitator Superfamily
C1703_RS07345	COG2851	Citrate transporter
C1703_RS07350	COG0243	molybdopterin cofactor binding
C1703_RS07355	COG1309	transcriptional regulator
C1703_RS07365	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1703_RS07370	COG2188	Transcriptional regulator
C1703_RS07405	COG1595	DNA-templated transcription, initiation
C1703_RS07430	COG2755	lipolytic protein G-D-S-L family
C1703_RS07445	COG1216	Glycosyl transferase, family 2
C1703_RS07450	COG0726	polysaccharide deacetylase
C1703_RS07450	COG1649	PFAM Uncharacterised BCR, COG1649
C1703_RS07470	COG1725	Transcriptional regulator
C1703_RS07485	COG2226	methyltransferase
C1703_RS07515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1703_RS07515	COG0662	Cupin 2, conserved barrel domain protein
C1703_RS07520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1703_RS07525	COG0587	DNA-directed DNA polymerase activity
C1703_RS07550	COG1799	cell septum assembly
C1703_RS07555	COG1960	acyl-CoA dehydrogenase activity
C1703_RS07560	COG0477	Major facilitator Superfamily
C1703_RS07570	COG0671	phosphoesterase, PA-phosphatase related
C1703_RS07605	COG0411	ABC transporter
C1703_RS07630	COG1160	GTP binding
C1703_RS07640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1703_RS07670	COG0494	nUDIX hydrolase
C1703_RS07675	COG1187	pseudouridine synthase activity
C1703_RS07680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1703_RS07685	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1703_RS07700	COG0686	Belongs to the AlaDH PNT family
C1703_RS07710	COG0494	nUDIX hydrolase
C1703_RS07715	COG0504	CTP synthase activity
C1703_RS07725	COG3387	PFAM Glycoside hydrolase 15-related
C1703_RS07745	COG0497	DNA recombination
C1703_RS07750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1703_RS07770	COG1120	ATPase activity
C1703_RS07775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1703_RS07780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1703_RS07785	COG0647	UMP catabolic process
C1703_RS07820	COG2094	Belongs to the DNA glycosylase MPG family
C1703_RS07830	COG1881	PFAM PEBP family protein
C1703_RS07850	COG1119	ATPase activity
C1703_RS07870	COG2197	response regulator
C1703_RS07885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1703_RS07895	COG0842	Transport permease protein
C1703_RS07895	COG1131	(ABC) transporter
C1703_RS07895	COG1716	ATPase activity
C1703_RS07905	COG3830	Belongs to the UPF0237 family
C1703_RS07905	COG0560	Phosphoserine phosphatase
C1703_RS07910	COG0588	phosphoglycerate mutase activity
C1703_RS07930	COG2807	transmembrane transport
C1703_RS07935	COG2186	Transcriptional regulator
C1703_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS07965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1703_RS07970	COG2261	transglycosylase associated protein
C1703_RS07985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1703_RS07990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1703_RS08005	COG1404	Belongs to the peptidase S8 family
C1703_RS08030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1703_RS08045	COG1966	Carbon starvation protein
C1703_RS08070	COG3387	PFAM Glycoside hydrolase 15-related
C1703_RS08120	COG0488	(ABC) transporter
C1703_RS08140	COG0235	Class ii aldolase
C1703_RS08165	COG1492	cobalamin metabolic process
C1703_RS08185	COG1797	cobyrinic acid a,c-diamide synthase activity
C1703_RS08215	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C1703_RS08240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1703_RS08245	COG2318	DinB family
C1703_RS08250	COG0456	acetyltransferase
C1703_RS08255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1703_RS08260	COG1917	Cupin 2, conserved barrel domain protein
C1703_RS08265	COG5285	phytanoyl-CoA dioxygenase
C1703_RS08270	COG3844	kynureninase activity
C1703_RS08275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1703_RS08295	COG1414	Transcriptional regulator
C1703_RS08310	COG4585	Histidine kinase
C1703_RS08315	COG2197	response regulator
C1703_RS08320	COG0768	penicillin binding
C1703_RS08325	COG2252	PERMEase
C1703_RS08330	COG1595	DNA-templated transcription, initiation
C1703_RS08365	COG4677	pectinesterase activity
C1703_RS08370	COG3866	Pectate lyase
C1703_RS08375	COG2755	lipolytic protein G-D-S-L family
C1703_RS08380	COG1653	transport
C1703_RS08390	COG3507	Belongs to the glycosyl hydrolase 43 family
C1703_RS08405	COG3866	Pectate lyase
C1703_RS08410	COG0395	ABC-type sugar transport system, permease component
C1703_RS08415	COG1175	transmembrane transport
C1703_RS08430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS08435	COG1802	Transcriptional regulator
C1703_RS08480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS08485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1703_RS08505	COG0395	ABC-type sugar transport system, permease component
C1703_RS08510	COG1063	alcohol dehydrogenase
C1703_RS08520	COG0142	geranyltranstransferase activity
C1703_RS08525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1703_RS08540	COG1309	transcriptional regulator
C1703_RS08550	COG1609	Transcriptional regulator
C1703_RS08560	COG2318	DinB family
C1703_RS08575	COG1802	Transcriptional regulator
C1703_RS08615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS08625	COG1595	DNA-templated transcription, initiation
C1703_RS08635	COG4974	Belongs to the 'phage' integrase family
C1703_RS08690	COG0494	nUDIX hydrolase
C1703_RS08705	COG2171	N-acyltransferase activity
C1703_RS08710	COG3226	Transcriptional regulator
C1703_RS08715	COG2076	Multidrug Resistance protein
C1703_RS08725	COG2151	metal-sulfur cluster biosynthetic enzyme
C1703_RS08730	COG0822	iron-sulfur transferase activity
C1703_RS08735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1703_RS08740	COG0396	ATPase activity
C1703_RS08750	COG0719	Fe-S assembly protein
C1703_RS08765	COG2746	aminoglycoside 3-N-acetyltransferase activity
C1703_RS08770	COG1131	(ABC) transporter
C1703_RS08780	COG1612	heme a metabolic process
C1703_RS08795	COG0109	protoheme IX farnesyltransferase activity
C1703_RS08810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1703_RS08825	COG0363	glucosamine-6-phosphate deaminase activity
C1703_RS08830	COG0395	ABC-type sugar transport system, permease component
C1703_RS08835	COG1175	transmembrane transport
C1703_RS08840	COG1653	transport
C1703_RS08845	COG0366	Alpha amylase catalytic
C1703_RS08855	COG1695	Transcriptional regulator
C1703_RS08860	COG1136	(ABC) transporter
C1703_RS08870	COG0166	Belongs to the GPI family
C1703_RS08885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1703_RS08890	COG0149	triose-phosphate isomerase activity
C1703_RS08895	COG0126	phosphoglycerate kinase activity
C1703_RS08900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1703_RS08910	COG1481	regulation of sporulation
C1703_RS08915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1703_RS08920	COG1660	Displays ATPase and GTPase activities
C1703_RS08925	COG0322	excinuclease ABC activity
C1703_RS08940	COG1105	Belongs to the carbohydrate kinase PfkB family
C1703_RS08955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1703_RS08970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1703_RS08975	COG0765	amino acid transport
C1703_RS08985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1703_RS08990	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1703_RS08995	COG0477	Major facilitator Superfamily
C1703_RS09000	COG0387	Pfam Sodium calcium exchanger
C1703_RS09025	COG0556	nucleotide-excision repair
C1703_RS09030	COG5001	Diguanylate cyclase
C1703_RS09030	COG3300	MHYT domain
C1703_RS09035	COG0584	glycerophosphoryl diester phosphodiesterase
C1703_RS09040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1703_RS09050	COG2313	pseudouridylate synthase activity
C1703_RS09060	COG2226	methyltransferase
C1703_RS09065	COG0598	Magnesium transport protein CorA
C1703_RS09095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1703_RS09100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1703_RS09150	COG0402	S-adenosylhomocysteine deaminase activity
C1703_RS09215	COG1953	Uracil, thiamine, allantoin
C1703_RS09220	COG1802	Transcriptional regulator
C1703_RS09260	COG2226	methyltransferase
C1703_RS09280	COG0237	dephospho-CoA kinase activity
C1703_RS09290	COG0539	negative regulation of cytoplasmic translation
C1703_RS09295	COG2226	methyltransferase
C1703_RS09295	COG1073	alpha beta
C1703_RS09300	COG1643	Atp-dependent helicase
C1703_RS09340	COG2050	protein possibly involved in aromatic compounds catabolism
C1703_RS09395	COG2968	Membrane
C1703_RS09400	COG0737	Belongs to the 5'-nucleotidase family
C1703_RS09420	COG0745	RESPONSE REGULATOR receiver
C1703_RS09425	COG1605	Chorismate mutase
C1703_RS09425	COG0287	Prephenate dehydrogenase
C1703_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS09450	COG1024	Enoyl-CoA hydratase
C1703_RS09470	COG0183	Belongs to the thiolase family
C1703_RS09475	COG1309	transcriptional regulator
C1703_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS09485	COG1960	acyl-CoA dehydrogenase activity
C1703_RS09500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1703_RS09510	COG1136	(ABC) transporter
C1703_RS09535	COG0067	glutamate synthase
C1703_RS09535	COG0070	glutamate synthase
C1703_RS09535	COG0069	glutamate synthase activity
C1703_RS09545	COG1397	ADP-ribosylglycohydrolase
C1703_RS09565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1703_RS09575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1703_RS09585	COG0159	tryptophan synthase activity
C1703_RS09590	COG0133	tryptophan synthase activity
C1703_RS09600	COG0134	indole-3-glycerol-phosphate synthase activity
C1703_RS09620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1703_RS09625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1703_RS09635	COG0107	imidazoleglycerol-phosphate synthase activity
C1703_RS09640	COG0251	oxidation-reduction process
C1703_RS09645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1703_RS09650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1703_RS09655	COG0131	Imidazoleglycerol-phosphate dehydratase
C1703_RS09660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1703_RS09665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1703_RS09685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1703_RS09705	COG1432	Conserved Protein
C1703_RS09715	COG0587	DNA-directed DNA polymerase activity
C1703_RS09770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1703_RS09785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1703_RS09790	COG3599	regulation of cell shape
C1703_RS09800	COG1799	cell septum assembly
C1703_RS09810	COG1496	oxidoreductase activity
C1703_RS09815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1703_RS09820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1703_RS09825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1703_RS09835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1703_RS09840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1703_RS09850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1703_RS09865	COG0275	rRNA processing
C1703_RS09875	COG0714	Associated with various cellular activities
C1703_RS09895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1703_RS09905	COG1126	abc transporter atp-binding protein
C1703_RS09915	COG1309	transcriptional regulator
C1703_RS09935	COG0352	thiamine-phosphate diphosphorylase activity
C1703_RS09950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS09950	COG2022	thiamine diphosphate biosynthetic process
C1703_RS09960	COG2022	thiamine diphosphate biosynthetic process
C1703_RS09965	COG0515	serine threonine protein kinase
C1703_RS09965	COG2815	serine threonine protein kinase
C1703_RS09970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1703_RS09975	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1703_RS09980	COG2193	ferroxidase activity
C1703_RS09985	COG0243	molybdopterin cofactor binding
C1703_RS09990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1703_RS10005	COG0205	6-phosphofructokinase activity
C1703_RS10010	COG2197	response regulator
C1703_RS10015	COG4585	Histidine kinase
C1703_RS10040	COG1940	carbohydrate kinase activity
C1703_RS10050	COG0003	Pfam Anion-transporting ATPase
C1703_RS10110	COG0534	Mate efflux family protein
C1703_RS10160	COG2205	protein histidine kinase activity
C1703_RS10165	COG0745	RESPONSE REGULATOR receiver
C1703_RS10175	COG1929	Belongs to the glycerate kinase type-1 family
C1703_RS10180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1703_RS10185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1703_RS10190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1703_RS10195	COG0723	plastoquinol--plastocyanin reductase activity
C1703_RS10200	COG2010	Cytochrome c
C1703_RS10205	COG1845	cytochrome c oxidase, subunit III
C1703_RS10215	COG1376	ErfK ybiS ycfS ynhG family protein
C1703_RS10225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1703_RS10230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1703_RS10240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS10265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1703_RS10270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1703_RS10275	COG2197	response regulator
C1703_RS10315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1703_RS10320	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1703_RS10335	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1703_RS10355	COG0438	transferase activity, transferring glycosyl groups
C1703_RS10370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1703_RS10375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1703_RS10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1703_RS10390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1703_RS10415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1703_RS10420	COG1090	epimerase
C1703_RS10435	COG0321	lipoyl(octanoyl) transferase activity
C1703_RS10440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1703_RS10460	COG0174	glutamine synthetase
C1703_RS10475	COG0501	Belongs to the peptidase M48B family
C1703_RS10500	COG0667	Aldo Keto reductase
C1703_RS10530	COG0745	RESPONSE REGULATOR receiver
C1703_RS10545	COG2197	response regulator
C1703_RS10570	COG1309	transcriptional regulator
C1703_RS10605	COG0366	Alpha amylase catalytic
C1703_RS10610	COG3833	ABC-type maltose transport systems, permease component
C1703_RS10615	COG1175	transmembrane transport
C1703_RS10625	COG1609	Transcriptional regulator
C1703_RS10635	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1703_RS10650	COG0174	glutamine synthetase
C1703_RS10660	COG1959	2 iron, 2 sulfur cluster binding
C1703_RS10680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1703_RS10680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1703_RS10695	COG2814	Major facilitator Superfamily
C1703_RS10710	COG0477	Major facilitator Superfamily
C1703_RS10715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1703_RS10740	COG1994	Peptidase M50
C1703_RS10775	COG5398	heme oxygenase
C1703_RS10795	COG2837	iron assimilation
C1703_RS10800	COG0672	)-iron permease
C1703_RS10815	COG0584	glycerophosphoryl diester phosphodiesterase
C1703_RS10845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1703_RS10850	COG2814	Major facilitator Superfamily
C1703_RS10860	COG3540	Alkaline phosphatase
C1703_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS10870	COG1686	Belongs to the peptidase S11 family
C1703_RS10875	COG0667	Aldo Keto reductase
C1703_RS10885	COG2259	Doxx family
C1703_RS10925	COG0363	glucosamine-6-phosphate deaminase activity
C1703_RS10965	COG3022	response to hydroperoxide
C1703_RS10970	COG0800	Aldolase
C1703_RS10985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1703_RS11005	COG2030	dehydratase
C1703_RS11025	COG1733	regulation of RNA biosynthetic process
C1703_RS11030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1703_RS11035	COG4585	Histidine kinase
C1703_RS11045	COG2197	response regulator
C1703_RS11050	COG0500	methyltransferase
C1703_RS11065	COG0477	Major facilitator Superfamily
C1703_RS11080	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1703_RS11090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS11125	COG0438	transferase activity, transferring glycosyl groups
C1703_RS11130	COG1309	transcriptional regulator
C1703_RS11175	COG1657	PFAM Prenyltransferase squalene oxidase
C1703_RS11190	COG3845	ABC transporter
C1703_RS11205	COG2124	cytochrome p450
C1703_RS11210	COG0183	Belongs to the thiolase family
C1703_RS11215	COG0477	Major facilitator Superfamily
C1703_RS11235	COG4122	O-methyltransferase activity
C1703_RS11275	COG3896	Chloramphenicol phosphotransferase-like protein
C1703_RS11305	COG2259	Doxx family
C1703_RS11325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1703_RS11435	COG0586	Pfam SNARE associated Golgi protein
C1703_RS11445	COG1358	cellular component organization or biogenesis
C1703_RS11490	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1703_RS11495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1703_RS11505	COG0477	Major facilitator Superfamily
C1703_RS11510	COG1309	transcriptional regulator
C1703_RS11525	COG0667	Aldo Keto reductase
C1703_RS11530	COG0789	Transcriptional regulator
C1703_RS11560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1703_RS11565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1703_RS11570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1703_RS11630	COG1764	response to oxidative stress
C1703_RS11635	COG2130	NADP-dependent
C1703_RS11675	COG1129	ABC transporter
C1703_RS11680	COG4214	carbohydrate transport
C1703_RS11700	COG3940	Belongs to the glycosyl hydrolase 43 family
C1703_RS11705	COG3507	Belongs to the glycosyl hydrolase 43 family
C1703_RS11765	COG0395	ABC-type sugar transport system, permease component
C1703_RS11770	COG1175	transmembrane transport
C1703_RS11795	COG3386	PFAM SMP-30 Gluconolaconase
C1703_RS11800	COG1414	Transcriptional regulator
C1703_RS11805	COG2310	stress, protein
C1703_RS11830	COG4981	capsule polysaccharide biosynthetic process
C1703_RS11885	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS11890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1703_RS11890	COG0825	malonyl-CoA metabolic process
C1703_RS11905	COG2255	four-way junction helicase activity
C1703_RS11920	COG1077	Cell shape determining protein MreB Mrl
C1703_RS11990	COG1070	Carbohydrate kinase
C1703_RS12005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1703_RS12010	COG0358	DNA primase activity
C1703_RS12020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1703_RS12030	COG2949	membrane
C1703_RS12075	COG0431	NADPH-dependent FMN reductase
C1703_RS12090	COG1733	regulation of RNA biosynthetic process
C1703_RS12105	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C1703_RS12110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1703_RS12120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1703_RS12140	COG0346	lactoylglutathione lyase activity
C1703_RS12155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1703_RS12160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1703_RS12160	COG2146	nitrite reductase [NAD(P)H] activity
C1703_RS12185	COG0659	secondary active sulfate transmembrane transporter activity
C1703_RS12195	COG0745	RESPONSE REGULATOR receiver
C1703_RS12200	COG0642	Histidine kinase
C1703_RS12235	COG0494	nUDIX hydrolase
C1703_RS12255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1703_RS12255	COG0574	Belongs to the PEP-utilizing enzyme family
C1703_RS12260	COG1846	Transcriptional regulator
C1703_RS12260	COG1940	carbohydrate kinase activity
C1703_RS12295	COG0456	acetyltransferase
C1703_RS12310	COG0667	Aldo Keto reductase
C1703_RS12315	COG1280	lysine exporter protein (LysE YggA)
C1703_RS12330	COG0423	glycine-tRNA ligase activity
C1703_RS12335	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1703_RS12335	COG3443	Belongs to the bacterial solute-binding protein 9 family
C1703_RS12340	COG1121	(ABC) transporter
C1703_RS12345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1703_RS12375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1703_RS12380	COG1381	Involved in DNA repair and RecF pathway recombination
C1703_RS12420	COG2186	Transcriptional regulator
C1703_RS12425	COG0747	negative chemotaxis
C1703_RS12435	COG0444	Belongs to the ABC transporter superfamily
C1703_RS12440	COG4608	Belongs to the ABC transporter superfamily
C1703_RS12445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS12450	COG2197	response regulator
C1703_RS12455	COG4585	Histidine kinase
C1703_RS12460	COG2409	Drug exporters of the RND superfamily
C1703_RS12470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1703_RS12490	COG2723	6-phospho-beta-galactosidase activity
C1703_RS12515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1703_RS12550	COG2315	Protein conserved in bacteria
C1703_RS12560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1703_RS12570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS12575	COG4948	Mandelate Racemase Muconate Lactonizing
C1703_RS12580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS12585	COG1414	Transcriptional regulator
C1703_RS12595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1703_RS12600	COG1234	tRNA 3'-trailer cleavage
C1703_RS12605	COG0537	adenosine 5'-monophosphoramidase activity
C1703_RS12610	COG0793	Belongs to the peptidase S41A family
C1703_RS12610	COG4946	Tricorn protease homolog
C1703_RS12635	COG0484	heat shock protein binding
C1703_RS12640	COG1420	regulation of RNA biosynthetic process
C1703_RS12665	COG0784	Response regulator, receiver
C1703_RS12665	COG2205	protein histidine kinase activity
C1703_RS12685	COG0481	GTPase activity
C1703_RS12695	COG0268	Binds directly to 16S ribosomal RNA
C1703_RS12720	COG2353	YceI-like domain
C1703_RS12735	COG1555	photosystem II stabilization
C1703_RS12735	COG1596	polysaccharide export
C1703_RS12740	COG1307	EDD domain protein, DegV family
C1703_RS12750	COG0495	leucyl-tRNA aminoacylation
C1703_RS12765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1703_RS12790	COG0588	phosphoglycerate mutase activity
C1703_RS12795	COG0799	negative regulation of ribosome biogenesis
C1703_RS12805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1703_RS12810	COG0501	Belongs to the peptidase M48B family
C1703_RS12825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1703_RS12835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1703_RS12845	COG1215	transferase activity, transferring glycosyl groups
C1703_RS12860	COG3540	Alkaline phosphatase
C1703_RS12870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1703_RS12875	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1703_RS12880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1703_RS12885	COG1530	ribonuclease E activity
C1703_RS12910	COG0772	Belongs to the SEDS family
C1703_RS12930	COG1077	Cell shape determining protein MreB Mrl
C1703_RS12935	COG0105	UTP biosynthetic process
C1703_RS12945	COG0285	dihydrofolate synthase activity
C1703_RS12950	COG0525	valine-tRNA ligase activity
C1703_RS12965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1703_RS12970	COG0740	serine-type endopeptidase activity
C1703_RS12975	COG0740	serine-type endopeptidase activity
C1703_RS12980	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1703_RS13000	COG0515	serine threonine protein kinase
C1703_RS13000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1703_RS13010	COG3594	Acyltransferase
C1703_RS13020	COG1674	ftsk spoiiie
C1703_RS13090	COG4552	Acetyltransferase involved in intracellular survival and related
C1703_RS13105	COG1113	amino acid transport
C1703_RS13110	COG0515	serine threonine protein kinase
C1703_RS13120	COG1268	BioY protein
C1703_RS13125	COG1113	amino acid transport
C1703_RS13130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1703_RS13140	COG0588	phosphoglycerate mutase activity
C1703_RS13150	COG1653	transport
C1703_RS13155	COG1175	transmembrane transport
C1703_RS13160	COG0395	ABC-type sugar transport system, permease component
C1703_RS13165	COG3842	ATPase activity
C1703_RS13190	COG0584	glycerophosphoryl diester phosphodiesterase
C1703_RS13200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1703_RS13260	COG0583	DNA-binding transcription factor activity
C1703_RS13270	COG0697	spore germination
C1703_RS13275	COG1846	Transcriptional regulator
C1703_RS13280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1703_RS13305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1703_RS13305	COG3291	Pkd domain containing protein
C1703_RS13315	COG1136	(ABC) transporter
C1703_RS13330	COG0668	transmembrane transport
C1703_RS13340	COG1486	melibiose metabolic process
C1703_RS13385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1703_RS13410	COG1522	sequence-specific DNA binding
C1703_RS13440	COG0629	single-stranded DNA binding
C1703_RS13445	COG0640	Transcriptional regulator
C1703_RS13470	COG2318	DinB family
C1703_RS13475	COG3903	Transcriptional regulator
C1703_RS13475	COG3629	intracellular signal transduction
C1703_RS13490	COG3903	Transcriptional regulator
C1703_RS13490	COG3629	intracellular signal transduction
C1703_RS13500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1703_RS13550	COG0438	transferase activity, transferring glycosyl groups
C1703_RS13575	COG0297	glycogen (starch) synthase activity
C1703_RS13655	COG3962	Belongs to the TPP enzyme family
C1703_RS13660	COG3718	enzyme involved in inositol metabolism
C1703_RS13670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS13710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1703_RS13730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1703_RS13750	COG1129	ABC transporter
C1703_RS13760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS13765	COG1869	D-ribose catabolic process
C1703_RS13785	COG0456	acetyltransferase
C1703_RS13855	COG3415	Transposase
C1703_RS13855	COG2801	Transposase and inactivated derivatives
C1703_RS13875	COG0673	inositol 2-dehydrogenase activity
C1703_RS13880	COG1609	Transcriptional regulator
C1703_RS13935	COG0583	DNA-binding transcription factor activity
C1703_RS13945	COG1846	Transcriptional regulator
C1703_RS13945	COG0456	acetyltransferase
C1703_RS13970	COG1132	(ABC) transporter
C1703_RS13975	COG1472	Belongs to the glycosyl hydrolase 3 family
C1703_RS14015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1703_RS14030	COG2326	polyphosphate kinase activity
C1703_RS14065	COG1946	Acyl-CoA thioesterase
C1703_RS14080	COG1309	transcriptional regulator
C1703_RS14085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1703_RS14100	COG1960	acyl-CoA dehydrogenase activity
C1703_RS14125	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C1703_RS14160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1703_RS14170	COG0589	response to stress
C1703_RS14180	COG4977	sequence-specific DNA binding
C1703_RS14185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1703_RS14195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1703_RS14220	COG0395	ABC-type sugar transport system, permease component
C1703_RS14240	COG3345	alpha-galactosidase
C1703_RS14245	COG0395	ABC-type sugar transport system, permease component
C1703_RS14265	COG0745	RESPONSE REGULATOR receiver
C1703_RS14275	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C1703_RS14290	COG0406	alpha-ribazole phosphatase activity
C1703_RS14340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS14370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1703_RS14375	COG0154	amidase activity
C1703_RS14385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1703_RS14390	COG0765	amino acid transport
C1703_RS14395	COG0765	amino acid transport
C1703_RS14400	COG1126	abc transporter atp-binding protein
C1703_RS14415	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS14425	COG3397	chitin binding
C1703_RS14445	COG2186	Transcriptional regulator
C1703_RS14460	COG4249	Peptidase C14 caspase catalytic subunit p20
C1703_RS14460	COG2319	Wd-40 repeat
C1703_RS14500	COG1940	carbohydrate kinase activity
C1703_RS14500	COG1846	Transcriptional regulator
C1703_RS14505	COG0673	inositol 2-dehydrogenase activity
C1703_RS14510	COG4702	Belongs to the UPF0303 family
C1703_RS14525	COG0706	membrane insertase activity
C1703_RS14560	COG0270	DNA (cytosine-5-)-methyltransferase activity
C1703_RS14590	COG1074	ATP-dependent DNA helicase activity
C1703_RS14635	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS14660	COG2267	carboxylic ester hydrolase activity
C1703_RS14700	COG2733	membrane
C1703_RS14710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1703_RS14715	COG4555	ABC transporter
C1703_RS14730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1703_RS14770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1703_RS14780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1703_RS14785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1703_RS14790	COG1263	PTS System
C1703_RS14795	COG1263	PTS System
C1703_RS14800	COG1234	tRNA 3'-trailer cleavage
C1703_RS14830	COG1113	amino acid transport
C1703_RS14840	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1703_RS14850	COG1335	isochorismatase
C1703_RS14910	COG0277	FAD linked oxidase domain protein
C1703_RS14915	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C1703_RS14925	COG1174	glycine betaine transport
C1703_RS14935	COG1174	glycine betaine transport
C1703_RS14940	COG1732	Glycine betaine
C1703_RS14960	COG1061	Type III restriction enzyme res subunit
C1703_RS14980	COG0596	Alpha beta hydrolase
C1703_RS14985	COG0789	Transcriptional regulator
C1703_RS15035	COG1678	Uncharacterized ACR, COG1678
C1703_RS15040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1703_RS15045	COG0776	regulation of translation
C1703_RS15055	COG3973	AAA domain
C1703_RS15080	COG2223	nitrite transmembrane transporter activity
C1703_RS15125	COG1501	Belongs to the glycosyl hydrolase 31 family
C1703_RS15130	COG1609	Transcriptional regulator
C1703_RS15140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1703_RS15145	COG0793	Belongs to the peptidase S41A family
C1703_RS15155	COG2884	Cell division ATP-binding protein ftsE
C1703_RS15170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1703_RS15175	COG0515	serine threonine protein kinase
C1703_RS15180	COG0515	serine threonine protein kinase
C1703_RS15195	COG1175	transmembrane transport
C1703_RS15200	COG0395	ABC-type sugar transport system, permease component
C1703_RS15205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C1703_RS15210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C1703_RS15215	COG1216	Glycosyl transferase, family 2
C1703_RS15220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1703_RS15230	COG1764	response to oxidative stress
C1703_RS15235	COG1846	Transcriptional regulator
C1703_RS15275	COG1134	teichoic acid transport
C1703_RS15280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C1703_RS15285	COG1216	Glycosyl transferase, family 2
C1703_RS15300	COG2902	Dehydrogenase
C1703_RS15320	COG0653	protein targeting
C1703_RS15330	COG3214	Protein conserved in bacteria
C1703_RS15335	COG2197	response regulator
C1703_RS15340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1703_RS15350	COG0823	Involved in the tonB-independent uptake of proteins
C1703_RS15355	COG5000	phosphorelay sensor kinase activity
C1703_RS15355	COG5002	protein histidine kinase activity
C1703_RS15360	COG0745	RESPONSE REGULATOR receiver
C1703_RS15430	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C1703_RS15450	COG0714	Associated with various cellular activities
C1703_RS15495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1703_RS15505	COG1482	cell wall glycoprotein biosynthetic process
C1703_RS15515	COG2835	tetraacyldisaccharide 4'-kinase activity
C1703_RS15520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1703_RS15525	COG1620	l-lactate permease
C1703_RS15565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1703_RS15570	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C1703_RS15570	COG0778	Nitroreductase
C1703_RS15595	COG1316	TRANSCRIPTIONal
C1703_RS15600	COG1316	TRANSCRIPTIONal
C1703_RS15605	COG1316	TRANSCRIPTIONal
C1703_RS15610	COG1316	TRANSCRIPTIONal
C1703_RS15625	COG1316	TRANSCRIPTIONal
C1703_RS15635	COG1316	TRANSCRIPTIONal
C1703_RS15650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1703_RS15675	COG0789	Transcriptional regulator
C1703_RS15680	COG1902	pentaerythritol trinitrate reductase activity
C1703_RS15705	COG2205	protein histidine kinase activity
C1703_RS15710	COG0745	RESPONSE REGULATOR receiver
C1703_RS15715	COG3104	oligopeptide transport
C1703_RS15735	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS15740	COG1191	sigma factor activity
C1703_RS15750	COG1228	amidohydrolase
C1703_RS15765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1703_RS15790	COG4221	oxidoreductase activity
C1703_RS15805	COG2755	lipolytic protein G-D-S-L family
C1703_RS15810	COG0183	Belongs to the thiolase family
C1703_RS15850	COG1136	(ABC) transporter
C1703_RS15855	COG0577	efflux transmembrane transporter activity
C1703_RS15860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1703_RS15865	COG1252	NADH dehydrogenase
C1703_RS15885	COG0148	phosphopyruvate hydratase activity
C1703_RS15980	COG0577	efflux transmembrane transporter activity
C1703_RS15985	COG1136	(ABC) transporter
C1703_RS15990	COG0477	Major facilitator Superfamily
C1703_RS16010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1703_RS16045	COG4585	Histidine kinase
C1703_RS16060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1703_RS16065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1703_RS16070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1703_RS16075	COG0193	aminoacyl-tRNA hydrolase activity
C1703_RS16090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1703_RS16100	COG1309	transcriptional regulator
C1703_RS16110	COG4106	trans-aconitate 2-methyltransferase activity
C1703_RS16120	COG2197	response regulator
C1703_RS16130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1703_RS16170	COG0488	(ABC) transporter
C1703_RS16180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1703_RS16185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1703_RS16190	COG3584	3D domain protein
C1703_RS16190	COG3583	domain protein
C1703_RS16195	COG0084	hydrolase, TatD family'
C1703_RS16230	COG0310	cobalt ion transport
C1703_RS16240	COG1122	ATPase activity
C1703_RS16245	COG1846	Transcriptional regulator
C1703_RS16250	COG1764	response to oxidative stress
C1703_RS16255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1703_RS16270	COG0442	prolyl-tRNA aminoacylation
C1703_RS16275	COG2409	Drug exporters of the RND superfamily
C1703_RS16285	COG4946	Tricorn protease homolog
C1703_RS16285	COG0793	Belongs to the peptidase S41A family
C1703_RS16300	COG2267	carboxylic ester hydrolase activity
C1703_RS16305	COG2072	flavoprotein involved in K transport
C1703_RS16315	COG0708	Exodeoxyribonuclease III
C1703_RS16340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1703_RS16345	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1703_RS16345	COG0315	cyclic pyranopterin monophosphate synthase activity
C1703_RS16350	COG0315	cyclic pyranopterin monophosphate synthase activity
C1703_RS16360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1703_RS16365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1703_RS16395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1703_RS16405	COG1970	mechanosensitive ion channel activity
C1703_RS16435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1703_RS16435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1703_RS16435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1703_RS16445	COG1349	DNA-binding transcription factor activity
C1703_RS16450	COG0477	Major facilitator Superfamily
C1703_RS16470	COG1247	-acetyltransferase
C1703_RS16475	COG3384	dioxygenase
C1703_RS16480	COG1846	Transcriptional regulator
C1703_RS16500	COG1414	Transcriptional regulator
C1703_RS16555	COG2188	Transcriptional regulator
C1703_RS16585	COG1192	Involved in chromosome partitioning
C1703_RS16630	COG0477	Major facilitator Superfamily
C1703_RS16640	COG1309	transcriptional regulator
C1703_RS16680	COG2814	Major facilitator Superfamily
C1703_RS16725	COG1846	Transcriptional regulator
C1703_RS16740	COG0386	Belongs to the glutathione peroxidase family
C1703_RS16765	COG1686	Belongs to the peptidase S11 family
C1703_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS16855	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C1703_RS16900	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS16930	COG3629	intracellular signal transduction
C1703_RS16930	COG3903	Transcriptional regulator
C1703_RS16945	COG3386	PFAM SMP-30 Gluconolaconase
C1703_RS16965	COG1024	Enoyl-CoA hydratase
C1703_RS16970	COG2267	carboxylic ester hydrolase activity
C1703_RS16990	COG1309	transcriptional regulator
C1703_RS17000	COG1960	acyl-CoA dehydrogenase activity
C1703_RS17020	COG0259	pyridoxamine-phosphate oxidase activity
C1703_RS17060	COG1024	Enoyl-CoA hydratase
C1703_RS17095	COG1960	acyl-CoA dehydrogenase activity
C1703_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS17120	COG1960	acyl-CoA dehydrogenase activity
C1703_RS17125	COG1960	acyl-CoA dehydrogenase activity
C1703_RS17145	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS17200	COG2945	thiolester hydrolase activity
C1703_RS17200	COG0596	Alpha beta hydrolase
C1703_RS17210	COG4821	SIS domain
C1703_RS17235	COG0259	pyridoxamine-phosphate oxidase activity
C1703_RS17250	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS17265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1703_RS17285	COG1309	transcriptional regulator
C1703_RS17290	COG2084	Dehydrogenase
C1703_RS17295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1703_RS17300	COG0277	FAD linked oxidase domain protein
C1703_RS17315	COG0789	Transcriptional regulator
C1703_RS17330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C1703_RS17390	COG0667	Aldo Keto reductase
C1703_RS17420	COG2252	PERMEase
C1703_RS17435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1703_RS17460	COG2814	Major facilitator Superfamily
C1703_RS17470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1703_RS17475	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C1703_RS17480	COG1278	Cold shock
C1703_RS17520	COG1061	Type III restriction enzyme res subunit
C1703_RS17530	COG3973	AAA domain
C1703_RS17575	COG1737	Transcriptional regulator
C1703_RS17580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1703_RS17630	COG0459	protein refolding
C1703_RS17635	COG1278	Cold shock
C1703_RS17650	COG0463	Glycosyl transferase, family 2
C1703_RS17655	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C1703_RS17695	COG5001	Diguanylate cyclase
C1703_RS17695	COG3300	MHYT domain
C1703_RS17790	COG2378	regulation of single-species biofilm formation
C1703_RS17795	COG3842	ATPase activity
C1703_RS17820	COG0215	cysteine-tRNA ligase activity
C1703_RS17825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1703_RS17830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1703_RS17835	COG1329	Transcriptional regulator
C1703_RS17875	COG2318	DinB family
C1703_RS17890	COG0588	phosphoglycerate mutase activity
C1703_RS17940	COG2207	Transcriptional regulator
C1703_RS17950	COG0438	transferase activity, transferring glycosyl groups
C1703_RS17995	COG2226	methyltransferase
C1703_RS18025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1703_RS18040	COG0546	phosphoglycolate phosphatase activity
C1703_RS18050	COG2186	Transcriptional regulator
C1703_RS18065	COG2188	Transcriptional regulator
C1703_RS18075	COG2188	Transcriptional regulator
C1703_RS18085	COG2188	Transcriptional regulator
C1703_RS18090	COG4552	Acetyltransferase involved in intracellular survival and related
C1703_RS18100	COG1490	D-aminoacyl-tRNA deacylase activity
C1703_RS18105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1703_RS18115	COG3485	protocatechuate 3,4-dioxygenase
C1703_RS18145	COG2897	thiosulfate sulfurtransferase activity
C1703_RS18170	COG0745	RESPONSE REGULATOR receiver
C1703_RS18175	COG1609	Transcriptional regulator
C1703_RS18180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1703_RS18190	COG0745	RESPONSE REGULATOR receiver
C1703_RS18220	COG0737	Belongs to the 5'-nucleotidase family
C1703_RS18225	COG0456	acetyltransferase
C1703_RS18305	COG1131	(ABC) transporter
C1703_RS18320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1703_RS18330	COG0406	alpha-ribazole phosphatase activity
C1703_RS18330	COG0494	nUDIX hydrolase
C1703_RS18350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1703_RS18355	COG0306	phosphate transporter
C1703_RS18365	COG1937	Protein conserved in bacteria
C1703_RS18375	COG0277	FAD linked oxidase domain protein
C1703_RS18380	COG0671	phosphoesterase, PA-phosphatase related
C1703_RS18385	COG1196	nuclear chromosome segregation
C1703_RS18385	COG0741	lytic transglycosylase activity
C1703_RS18385	COG0739	heme binding
C1703_RS18445	COG1131	(ABC) transporter
C1703_RS18455	COG4585	Histidine kinase
C1703_RS18460	COG2197	response regulator
C1703_RS18500	COG1252	NADH dehydrogenase
C1703_RS18535	COG0579	oxidoreductase
C1703_RS18540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1703_RS18550	COG0667	Aldo Keto reductase
C1703_RS18565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1703_RS18565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1703_RS18575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1703_RS18585	COG1191	sigma factor activity
C1703_RS18600	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS18605	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS18610	COG2172	sigma factor antagonist activity
C1703_RS18620	COG1295	ribonuclease BN
C1703_RS18660	COG0513	Belongs to the DEAD box helicase family
C1703_RS18760	COG2188	Transcriptional regulator
C1703_RS18780	COG1643	Atp-dependent helicase
C1703_RS18805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1703_RS18815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1703_RS18845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1703_RS18850	COG0047	phosphoribosylformylglycinamidine synthase activity
C1703_RS18855	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1703_RS18890	COG2197	response regulator
C1703_RS18900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1703_RS18915	COG0151	Belongs to the GarS family
C1703_RS18985	COG1801	Protein of unknown function DUF72
C1703_RS19010	COG2375	cellular response to nickel ion
C1703_RS19010	COG1132	(ABC) transporter
C1703_RS19035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1703_RS19065	COG1191	sigma factor activity
C1703_RS19070	COG1191	sigma factor activity
C1703_RS19095	COG2353	YceI-like domain
C1703_RS19115	COG3467	pyridoxamine 5'-phosphate
C1703_RS19125	COG0477	Major facilitator Superfamily
C1703_RS19130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1703_RS19140	COG2205	protein histidine kinase activity
C1703_RS19145	COG0745	RESPONSE REGULATOR receiver
C1703_RS19160	COG1846	Transcriptional regulator
C1703_RS19205	COG0784	Response regulator, receiver
C1703_RS19215	COG1309	transcriptional regulator
C1703_RS19220	COG2814	Major facilitator Superfamily
C1703_RS19225	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS19230	COG1595	DNA-templated transcription, initiation
C1703_RS19280	COG2319	Wd-40 repeat
C1703_RS19280	COG4249	Peptidase C14 caspase catalytic subunit p20
C1703_RS19295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1703_RS19315	COG0583	DNA-binding transcription factor activity
C1703_RS19340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1703_RS19360	COG0653	protein targeting
C1703_RS19380	COG0006	proline dipeptidase activity
C1703_RS19385	COG0751	glycine-tRNA ligase activity
C1703_RS19385	COG0752	glycyl-tRNA synthetase alpha subunit
C1703_RS19405	COG1999	signal sequence binding
C1703_RS19420	COG2837	iron assimilation
C1703_RS19430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1703_RS19435	COG0561	phosphatase activity
C1703_RS19460	COG1131	(ABC) transporter
C1703_RS19470	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C1703_RS19480	COG0561	phosphatase activity
C1703_RS19485	COG0739	heme binding
C1703_RS19485	COG1196	nuclear chromosome segregation
C1703_RS19485	COG0741	lytic transglycosylase activity
C1703_RS19490	COG4988	ABC transporter
C1703_RS19495	COG1294	oxidase, subunit
C1703_RS19500	COG1271	oxidase subunit
C1703_RS19510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1703_RS19515	COG1609	Transcriptional regulator
C1703_RS19535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1703_RS19560	COG0662	Cupin 2, conserved barrel domain protein
C1703_RS19565	COG1950	PFAM Membrane protein of
C1703_RS19570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1703_RS19575	COG0626	cystathionine gamma-synthase activity
C1703_RS19580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1703_RS19610	COG2814	Major facilitator Superfamily
C1703_RS19625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1703_RS19630	COG0305	Participates in initiation and elongation during chromosome replication
C1703_RS19640	COG0359	binds to the 23S rRNA
C1703_RS19645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1703_RS19650	COG0629	single-stranded DNA binding
C1703_RS19655	COG0360	Binds together with S18 to 16S ribosomal RNA
C1703_RS19680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1703_RS19705	COG0617	tRNA 3'-terminal CCA addition
C1703_RS19720	COG2815	serine threonine protein kinase
C1703_RS19720	COG0515	serine threonine protein kinase
C1703_RS19725	COG1595	DNA-templated transcription, initiation
C1703_RS19735	COG0492	ferredoxin-NADP+ reductase activity
C1703_RS19740	COG3118	belongs to the thioredoxin family
C1703_RS19755	COG1192	Involved in chromosome partitioning
C1703_RS19760	COG0357	Ribosomal RNA small subunit methyltransferase G
C1703_RS19770	COG0706	membrane insertase activity
C1703_RS19775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1703_RS19780	COG0594	ribonuclease P activity
C1703_RS19785	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1703_RS19790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1703_RS19800	COG0592	DNA-directed DNA polymerase activity
C1703_RS19805	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C1703_RS19810	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1703_RS19815	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C1703_RS19820	COG0187	DNA topoisomerase II activity
C1703_RS19825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1703_RS19885	COG0705	Rhomboid family
C1703_RS19900	COG3764	Sortase (surface protein transpeptidase)
C1703_RS19915	COG3764	Sortase (surface protein transpeptidase)
C1703_RS19920	COG3764	Sortase (surface protein transpeptidase)
C1703_RS19925	COG0515	serine threonine protein kinase
C1703_RS19935	COG0768	penicillin binding
C1703_RS19950	COG1716	ATPase activity
C1703_RS19955	COG1716	ATPase activity
C1703_RS19970	COG0577	efflux transmembrane transporter activity
C1703_RS19970	COG1136	(ABC) transporter
C1703_RS19980	COG2197	response regulator
C1703_RS20055	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1703_RS20060	COG1309	transcriptional regulator
C1703_RS20070	COG1522	sequence-specific DNA binding
C1703_RS20115	COG3321	synthase
C1703_RS20115	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS20115	COG0604	alcohol dehydrogenase
C1703_RS20130	COG0515	serine threonine protein kinase
C1703_RS20135	COG0515	serine threonine protein kinase
C1703_RS20145	COG0022	dehydrogenase e1 component
C1703_RS20150	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1703_RS20155	COG3409	Peptidoglycan-binding domain 1 protein
C1703_RS20240	COG1362	aminopeptidase activity
C1703_RS20245	COG1960	acyl-CoA dehydrogenase activity
C1703_RS20265	COG0477	Major facilitator Superfamily
C1703_RS20270	COG1741	Belongs to the pirin family
C1703_RS20285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1703_RS20305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1703_RS20325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1703_RS20330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1703_RS20360	COG1653	transport
C1703_RS20375	COG0701	Predicted permease
C1703_RS20395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1703_RS20405	COG1595	DNA-templated transcription, initiation
C1703_RS20415	COG1957	nucleoside hydrolase
C1703_RS20425	COG0366	Alpha amylase catalytic
C1703_RS20485	COG2367	Beta-lactamase
C1703_RS20490	COG0768	penicillin binding
C1703_RS20495	COG0583	DNA-binding transcription factor activity
C1703_RS20520	COG1595	DNA-templated transcription, initiation
C1703_RS20540	COG0714	Associated with various cellular activities
C1703_RS20555	COG4948	Mandelate Racemase Muconate Lactonizing
C1703_RS20595	COG2267	carboxylic ester hydrolase activity
C1703_RS20610	COG1609	Transcriptional regulator
C1703_RS20625	COG2197	response regulator
C1703_RS20640	COG0438	transferase activity, transferring glycosyl groups
C1703_RS20650	COG0513	Belongs to the DEAD box helicase family
C1703_RS20655	COG1278	Cold shock
C1703_RS20660	COG2409	Drug exporters of the RND superfamily
C1703_RS20665	COG4585	Histidine kinase
C1703_RS20670	COG2197	response regulator
C1703_RS20685	COG4585	Histidine kinase
C1703_RS20690	COG0640	Transcriptional regulator
C1703_RS20745	COG1595	DNA-templated transcription, initiation
C1703_RS20750	COG1252	NADH dehydrogenase
C1703_RS20785	COG0513	Belongs to the DEAD box helicase family
C1703_RS20790	COG1278	Cold shock
C1703_RS20830	COG1482	cell wall glycoprotein biosynthetic process
C1703_RS20835	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS20865	COG0596	Alpha beta hydrolase
C1703_RS20895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1703_RS20905	COG0525	valine-tRNA ligase activity
C1703_RS20925	COG4566	intracellular signal transduction
C1703_RS20930	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1703_RS20940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1703_RS20945	COG1301	dicarboxylic acid transport
C1703_RS20950	COG0431	NADPH-dependent FMN reductase
C1703_RS20970	COG3852	Histidine kinase
C1703_RS20985	COG3321	synthase
C1703_RS20985	COG0604	alcohol dehydrogenase
C1703_RS21005	COG2226	methyltransferase
C1703_RS21010	COG2409	Drug exporters of the RND superfamily
C1703_RS21070	COG1621	beta-fructofuranosidase activity
C1703_RS21095	COG1609	Transcriptional regulator
C1703_RS21140	COG1132	(ABC) transporter
C1703_RS21155	COG2197	response regulator
C1703_RS21160	COG4585	Histidine kinase
C1703_RS21175	COG0642	Histidine kinase
C1703_RS21180	COG0745	RESPONSE REGULATOR receiver
C1703_RS21185	COG0671	phosphoesterase, PA-phosphatase related
C1703_RS21190	COG0671	phosphoesterase, PA-phosphatase related
C1703_RS21240	COG2188	Transcriptional regulator
C1703_RS21250	COG2188	Transcriptional regulator
C1703_RS21310	COG0717	Belongs to the dCTP deaminase family
C1703_RS21315	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1703_RS21375	COG0247	lactate metabolic process
C1703_RS21375	COG2181	nitrate reductase activity
C1703_RS21380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1703_RS21385	COG0443	Heat shock 70 kDa protein
C1703_RS21390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1703_RS21395	COG0484	heat shock protein binding
C1703_RS21400	COG0789	Transcriptional regulator
C1703_RS21405	COG4213	ABC transporter substrate-binding protein
C1703_RS21450	COG0542	response to heat
C1703_RS21480	COG0270	DNA (cytosine-5-)-methyltransferase activity
C1703_RS21495	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1703_RS21500	COG2188	Transcriptional regulator
C1703_RS21535	COG1674	ftsk spoiiie
C1703_RS21595	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C1703_RS21610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1703_RS21635	COG3844	kynureninase activity
C1703_RS21660	COG4585	Histidine kinase
C1703_RS21665	COG2197	response regulator
C1703_RS21675	COG2197	response regulator
C1703_RS21680	COG2124	cytochrome p450
C1703_RS21690	COG3559	Exporter of polyketide antibiotics
C1703_RS21695	COG1131	(ABC) transporter
C1703_RS21710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1703_RS21725	COG1802	Transcriptional regulator
C1703_RS21730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1703_RS21735	COG0693	protein deglycase activity
C1703_RS21750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1703_RS21760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1703_RS21765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1703_RS21795	COG5002	protein histidine kinase activity
C1703_RS21800	COG0745	RESPONSE REGULATOR receiver
C1703_RS21840	COG0701	Predicted permease
C1703_RS21880	COG1408	metallophosphoesterase
C1703_RS21905	COG0003	Pfam Anion-transporting ATPase
C1703_RS21930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1703_RS21970	COG2267	carboxylic ester hydrolase activity
C1703_RS21980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1703_RS21985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1703_RS21990	COG0659	secondary active sulfate transmembrane transporter activity
C1703_RS22045	COG1205	dead DEAH box helicase
C1703_RS22045	COG1111	helicase
C1703_RS22050	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS22060	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C1703_RS22070	COG2890	protein-(glutamine-N5) methyltransferase activity
C1703_RS22080	COG1754	DNA topoisomerase type I activity
C1703_RS22080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1703_RS22085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1703_RS22155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1703_RS22175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1703_RS22180	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
C1703_RS22180	COG0028	Belongs to the TPP enzyme family
C1703_RS22190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1703_RS22195	COG0191	fructose-bisphosphate aldolase activity
C1703_RS22200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1703_RS22205	COG0697	spore germination
C1703_RS22225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1703_RS22225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1703_RS22250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1703_RS22255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1703_RS22260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1703_RS22265	COG0254	rRNA binding
C1703_RS22275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1703_RS22300	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS22320	COG2318	DinB family
C1703_RS22330	COG0076	glutamate decarboxylase activity
C1703_RS22340	COG0789	Transcriptional regulator
C1703_RS22345	COG0393	Putative heavy-metal-binding
C1703_RS22350	COG0586	Pfam SNARE associated Golgi protein
C1703_RS22360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1703_RS22365	COG2027	D-alanyl-D-alanine carboxypeptidase
C1703_RS22380	COG0037	tRNA processing
C1703_RS22395	COG0302	gtp cyclohydrolase
C1703_RS22410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1703_RS22425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1703_RS22425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1703_RS22450	COG0649	NAD binding
C1703_RS22470	COG0640	Transcriptional regulator
C1703_RS22490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1703_RS22495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1703_RS22505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1703_RS22525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1703_RS22560	COG0739	heme binding
C1703_RS22580	COG0346	lactoylglutathione lyase activity
C1703_RS22585	COG2205	protein histidine kinase activity
C1703_RS22590	COG0745	RESPONSE REGULATOR receiver
C1703_RS22600	COG1595	DNA-templated transcription, initiation
C1703_RS22605	COG1194	a g-specific adenine glycosylase
C1703_RS22620	COG0671	phosphoesterase, PA-phosphatase related
C1703_RS22630	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C1703_RS22650	COG0248	Ppx GppA phosphatase
C1703_RS22655	COG1082	Xylose isomerase domain protein TIM barrel
C1703_RS22660	COG1309	transcriptional regulator
C1703_RS22665	COG0129	dihydroxy-acid dehydratase activity
C1703_RS22670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1703_RS22670	COG0515	serine threonine protein kinase
C1703_RS22675	COG4991	sh3 domain protein
C1703_RS22690	COG1129	ABC transporter
C1703_RS22690	COG0842	Transport permease protein
C1703_RS22700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1703_RS22705	COG0180	Tryptophanyl-tRNA synthetase
C1703_RS22730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1703_RS22740	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1703_RS22790	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C1703_RS22795	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1703_RS22800	COG0181	hydroxymethylbilane synthase activity
C1703_RS22805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1703_RS22805	COG1648	precorrin-2 dehydrogenase activity
C1703_RS22815	COG0113	porphobilinogen synthase activity
C1703_RS22830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1703_RS22845	COG2318	DinB family
C1703_RS22860	COG3903	Transcriptional regulator
C1703_RS22860	COG3629	intracellular signal transduction
C1703_RS22865	COG0018	arginyl-trna synthetase
C1703_RS22870	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C1703_RS22890	COG1690	Belongs to the RtcB family
C1703_RS22910	COG1742	UPF0060 membrane protein
C1703_RS22920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS22930	COG2205	protein histidine kinase activity
C1703_RS22935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1703_RS22950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1703_RS22955	COG1333	cytochrome c biogenesis protein
C1703_RS22960	COG0785	Cytochrome C biogenesis protein
C1703_RS22975	COG0406	alpha-ribazole phosphatase activity
C1703_RS22980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1703_RS23000	COG0789	Transcriptional regulator
C1703_RS23005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1703_RS23035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1703_RS23050	COG0163	prenyltransferase activity
C1703_RS23060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C1703_RS23065	COG1573	uracil-dna glycosylase
C1703_RS23080	COG1301	dicarboxylic acid transport
C1703_RS23085	COG1309	transcriptional regulator
C1703_RS23100	COG0183	Belongs to the thiolase family
C1703_RS23110	COG4213	ABC transporter substrate-binding protein
C1703_RS23115	COG1309	transcriptional regulator
C1703_RS23125	COG1053	succinate dehydrogenase
C1703_RS23130	COG2226	methyltransferase
C1703_RS23140	COG1278	Cold shock
C1703_RS23145	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C1703_RS23155	COG0515	serine threonine protein kinase
C1703_RS23155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1703_RS23175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C1703_RS23180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C1703_RS23200	COG2226	methyltransferase
C1703_RS23215	COG0242	peptide deformylase activity
C1703_RS23225	COG3103	Sh3 type 3 domain protein
C1703_RS23225	COG1388	LysM domain
C1703_RS23225	COG0791	NLP P60 protein
C1703_RS23235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1703_RS23240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1703_RS23245	COG0649	NAD binding
C1703_RS23255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1703_RS23260	COG1034	ATP synthesis coupled electron transport
C1703_RS23265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1703_RS23270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1703_RS23275	COG0839	Belongs to the complex I subunit 6 family
C1703_RS23280	COG0713	ATP synthesis coupled electron transport
C1703_RS23285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1703_RS23295	COG1007	ATP synthesis coupled electron transport
C1703_RS23305	COG0514	ATP-dependent DNA helicase (RecQ)
C1703_RS23310	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1703_RS23320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1703_RS23335	COG2188	Transcriptional regulator
C1703_RS23350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1703_RS23390	COG0561	phosphatase activity
C1703_RS23395	COG3953	SLT domain
C1703_RS23395	COG5280	Phage tail tape measure protein TP901
C1703_RS23400	COG0142	geranyltranstransferase activity
C1703_RS23410	COG1131	(ABC) transporter
C1703_RS23435	COG4935	Belongs to the peptidase S8 family
C1703_RS23435	COG2234	aminopeptidase activity
C1703_RS23450	COG1733	regulation of RNA biosynthetic process
C1703_RS23465	COG0702	epimerase
C1703_RS23470	COG1733	regulation of RNA biosynthetic process
C1703_RS23475	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1703_RS23480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1703_RS23480	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1703_RS23500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1703_RS23505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1703_RS23515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1703_RS23520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1703_RS23525	COG0839	Belongs to the complex I subunit 6 family
C1703_RS23530	COG0713	ATP synthesis coupled electron transport
C1703_RS23535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1703_RS23540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1703_RS23545	COG1007	ATP synthesis coupled electron transport
C1703_RS23550	COG0501	Belongs to the peptidase M48B family
C1703_RS23555	COG3304	Inner membrane component domain
C1703_RS23560	COG2261	transglycosylase associated protein
C1703_RS23565	COG1666	GTP binding
C1703_RS23585	COG0142	geranyltranstransferase activity
C1703_RS23590	COG1131	(ABC) transporter
C1703_RS23625	COG0702	epimerase
C1703_RS23645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1703_RS23650	COG2030	dehydratase
C1703_RS23665	COG0477	Major facilitator Superfamily
C1703_RS23670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1703_RS23675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1703_RS23680	COG0436	Aminotransferase
C1703_RS23690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1703_RS23695	COG0250	Participates in transcription elongation, termination and antitermination
C1703_RS23700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1703_RS23705	COG0081	regulation of translation
C1703_RS23720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1703_RS23725	COG0222	ribosome binding
C1703_RS23735	COG0085	RNA polymerase activity
C1703_RS23740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1703_RS23755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1703_RS23760	COG0049	tRNA binding
C1703_RS23765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1703_RS23770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1703_RS23790	COG0051	transcription antitermination factor activity, RNA binding
C1703_RS23795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1703_RS23800	COG0088	Forms part of the polypeptide exit tunnel
C1703_RS23805	COG0089	rRNA binding
C1703_RS23810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1703_RS23815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1703_RS23820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1703_RS23825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1703_RS23830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1703_RS23835	COG0255	Belongs to the universal ribosomal protein uL29 family
C1703_RS23840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1703_RS23845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1703_RS23850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1703_RS23855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1703_RS23860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1703_RS23870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1703_RS23875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1703_RS23880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1703_RS23885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1703_RS23890	COG1841	ribosomal large subunit assembly
C1703_RS23895	COG0200	Binds to the 23S rRNA
C1703_RS23905	COG0563	adenylate kinase activity
C1703_RS23925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1703_RS23930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1703_RS23935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1703_RS23940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1703_RS23945	COG0202	RNA polymerase activity
C1703_RS23950	COG0203	ribosomal protein L17
C1703_RS23955	COG0101	tRNA pseudouridine synthase activity
C1703_RS23970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1703_RS23975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1703_RS23980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1703_RS23990	COG1072	(Pantothenic acid kinase))
C1703_RS24005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1703_RS24020	COG0736	holo-[acyl-carrier-protein] synthase activity
C1703_RS24040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1703_RS24050	COG0802	atpase or kinase
C1703_RS24065	COG0456	acetyltransferase
C1703_RS24065	COG1214	PFAM Peptidase M22, glycoprotease
C1703_RS24075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1703_RS24090	COG1609	Transcriptional regulator
C1703_RS24100	COG1316	TRANSCRIPTIONal
C1703_RS24110	COG4941	Belongs to the sigma-70 factor family
C1703_RS24120	COG0726	polysaccharide deacetylase
C1703_RS24125	COG0726	polysaccharide deacetylase
C1703_RS24130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1703_RS24135	COG0459	protein refolding
C1703_RS24150	COG4221	oxidoreductase activity
C1703_RS24160	COG0583	DNA-binding transcription factor activity
C1703_RS24175	COG1595	DNA-templated transcription, initiation
C1703_RS24185	COG0516	GMP reductase activity
C1703_RS24195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1703_RS24210	COG0515	serine threonine protein kinase
C1703_RS24210	COG2815	serine threonine protein kinase
C1703_RS24215	COG0515	serine threonine protein kinase
C1703_RS24225	COG0515	serine threonine protein kinase
C1703_RS24230	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS24255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1703_RS24255	COG0519	Catalyzes the synthesis of GMP from XMP
C1703_RS24300	COG2197	response regulator
C1703_RS24330	COG0739	heme binding
C1703_RS24335	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1703_RS24340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS24340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS24355	COG0714	Associated with various cellular activities
C1703_RS24360	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1703_RS24365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C1703_RS24375	COG0045	succinate-CoA ligase (ADP-forming) activity
C1703_RS24410	COG0138	bifunctional purine biosynthesis protein purh
C1703_RS24425	COG0515	serine threonine protein kinase
C1703_RS24425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1703_RS24440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1703_RS24455	COG0039	L-malate dehydrogenase activity
C1703_RS24465	COG2318	DinB family
C1703_RS24470	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS24480	COG0517	IMP dehydrogenase activity
C1703_RS24480	COG4175	Glycine betaine
C1703_RS24485	COG4176	ABC-type proline glycine betaine transport system permease component
C1703_RS24500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1703_RS24505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1703_RS24510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1703_RS24520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1703_RS24520	COG0512	Glutamine amidotransferase of anthranilate synthase
C1703_RS24535	COG0754	glutathionylspermidine amidase activity
C1703_RS24540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1703_RS24560	COG0180	Tryptophanyl-tRNA synthetase
C1703_RS24580	COG0671	phosphoesterase, PA-phosphatase related
C1703_RS24595	COG1295	ribonuclease BN
C1703_RS24600	COG1686	Belongs to the peptidase S11 family
C1703_RS24610	COG1408	metallophosphoesterase
C1703_RS24615	COG0747	negative chemotaxis
C1703_RS24620	COG1309	transcriptional regulator
C1703_RS24635	COG1053	succinate dehydrogenase
C1703_RS24645	COG2009	succinate dehydrogenase
C1703_RS24655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1703_RS24710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS24710	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS24735	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1703_RS24745	COG1216	Glycosyl transferase, family 2
C1703_RS24760	COG2089	acid synthase
C1703_RS24780	COG2226	methyltransferase
C1703_RS24785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1703_RS24785	COG1473	amidohydrolase
C1703_RS24790	COG1744	ABC transporter substrate-binding protein PnrA-like
C1703_RS24795	COG1744	ABC transporter substrate-binding protein PnrA-like
C1703_RS24800	COG3845	ABC transporter
C1703_RS24810	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1703_RS24845	COG0592	DNA-directed DNA polymerase activity
C1703_RS24850	COG2814	Major facilitator Superfamily
C1703_RS24855	COG0583	DNA-binding transcription factor activity
C1703_RS24865	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1703_RS24890	COG2205	protein histidine kinase activity
C1703_RS24895	COG0745	RESPONSE REGULATOR receiver
C1703_RS24900	COG1595	DNA-templated transcription, initiation
C1703_RS24915	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS24920	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS24935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1703_RS24960	COG4770	biotin carboxylase activity
C1703_RS24970	COG0424	maF-like protein
C1703_RS24980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1703_RS24990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1703_RS25000	COG1024	Enoyl-CoA hydratase
C1703_RS25010	COG2986	histidine ammonia-lyase
C1703_RS25035	COG1404	Belongs to the peptidase S8 family
C1703_RS25050	COG1064	alcohol dehydrogenase
C1703_RS25075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1703_RS25095	COG1595	DNA-templated transcription, initiation
C1703_RS25100	COG2255	four-way junction helicase activity
C1703_RS25105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1703_RS25120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1703_RS25130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1703_RS25160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1703_RS25210	COG2814	Major facilitator Superfamily
C1703_RS25225	COG1331	Highly conserved protein containing a thioredoxin domain
C1703_RS25255	COG1309	transcriptional regulator
C1703_RS25265	COG1272	protein, Hemolysin III
C1703_RS25270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1703_RS25275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS25290	COG0436	Aminotransferase
C1703_RS25305	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C1703_RS25320	COG1414	Transcriptional regulator
C1703_RS25325	COG0251	oxidation-reduction process
C1703_RS25330	COG2610	gluconate transmembrane transporter activity
C1703_RS25385	COG2894	cell division
C1703_RS25420	COG3920	Histidine kinase
C1703_RS25485	COG2226	methyltransferase
C1703_RS25490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1703_RS25495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1703_RS25510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1703_RS25515	COG0450	alkyl hydroperoxide reductase
C1703_RS25530	COG1136	(ABC) transporter
C1703_RS25550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1703_RS25570	COG0114	fumarate hydratase activity
C1703_RS25575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C1703_RS25575	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C1703_RS25600	COG0778	Nitroreductase
C1703_RS25605	COG1722	exodeoxyribonuclease VII activity
C1703_RS25610	COG1570	exodeoxyribonuclease VII activity
C1703_RS25620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1703_RS25625	COG1940	carbohydrate kinase activity
C1703_RS25635	COG0012	GTP binding
C1703_RS25680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1703_RS25705	COG0667	Aldo Keto reductase
C1703_RS25795	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C1703_RS25845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1703_RS25850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1703_RS25890	COG0386	Belongs to the glutathione peroxidase family
C1703_RS25895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1703_RS25900	COG0583	DNA-binding transcription factor activity
C1703_RS26015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1703_RS26020	COG1053	succinate dehydrogenase
C1703_RS26045	COG1217	gtp-binding protein TYPA
C1703_RS26055	COG0601	transmembrane transport
C1703_RS26060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS26065	COG0444	Belongs to the ABC transporter superfamily
C1703_RS26070	COG4608	Belongs to the ABC transporter superfamily
C1703_RS26090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1703_RS26105	COG1131	(ABC) transporter
C1703_RS26115	COG4585	Histidine kinase
C1703_RS26120	COG2197	response regulator
C1703_RS26155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1703_RS26165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1703_RS26175	COG2818	Glycosylase
C1703_RS26180	COG1024	Enoyl-CoA hydratase
C1703_RS26195	COG1595	DNA-templated transcription, initiation
C1703_RS26205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1703_RS26210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1703_RS26245	COG0598	Magnesium transport protein CorA
C1703_RS26255	COG2814	Major facilitator Superfamily
C1703_RS26265	COG0613	PHP domain protein
C1703_RS26270	COG2095	MarC family integral membrane protein
C1703_RS26285	COG1432	Conserved Protein
C1703_RS26295	COG0513	Belongs to the DEAD box helicase family
C1703_RS26340	COG0438	transferase activity, transferring glycosyl groups
C1703_RS26365	COG0596	Alpha beta hydrolase
C1703_RS26390	COG0210	DNA helicase
C1703_RS26395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1703_RS26435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1703_RS26490	COG3480	Lon protease (S16) C-terminal proteolytic domain
C1703_RS26500	COG1615	UPF0182 protein
C1703_RS26530	COG0483	inositol monophosphate 1-phosphatase activity
C1703_RS26545	COG1162	GTPase activity
C1703_RS26550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1703_RS26560	COG2135	peptidase activity
C1703_RS26570	COG1595	DNA-templated transcription, initiation
C1703_RS26575	COG5662	AntiSigma factor
C1703_RS26580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1703_RS26580	COG2199	diguanylate cyclase activity
C1703_RS26595	COG0242	peptide deformylase activity
C1703_RS26605	COG2124	cytochrome p450
C1703_RS26610	COG4977	sequence-specific DNA binding
C1703_RS26640	COG2188	Transcriptional regulator
C1703_RS26645	COG2182	Extracellular solute-binding protein
C1703_RS26650	COG1175	transmembrane transport
C1703_RS26655	COG0395	ABC-type sugar transport system, permease component
C1703_RS26660	COG1472	Belongs to the glycosyl hydrolase 3 family
C1703_RS26665	COG1476	TRANSCRIPTIONal
C1703_RS26675	COG0363	glucosamine-6-phosphate deaminase activity
C1703_RS26680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1703_RS26695	COG1597	lipid kinase activity
C1703_RS26735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1703_RS26740	COG0142	geranyltranstransferase activity
C1703_RS26745	COG0456	acetyltransferase
C1703_RS26760	COG4941	Belongs to the sigma-70 factor family
C1703_RS26800	COG4106	trans-aconitate 2-methyltransferase activity
C1703_RS26805	COG1126	abc transporter atp-binding protein
C1703_RS26815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1703_RS26825	COG0281	malic enzyme
C1703_RS26830	COG0604	alcohol dehydrogenase
C1703_RS26865	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1703_RS26865	COG0567	Dehydrogenase, E1 component
C1703_RS26870	COG2205	protein histidine kinase activity
C1703_RS26875	COG0745	RESPONSE REGULATOR receiver
C1703_RS26895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1703_RS26945	COG1309	transcriptional regulator
C1703_RS26955	COG2828	Protein conserved in bacteria
C1703_RS26995	COG2205	protein histidine kinase activity
C1703_RS27015	COG3285	dna ligase
C1703_RS27015	COG1793	dna ligase
C1703_RS27020	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C1703_RS27030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C1703_RS27090	COG0515	serine threonine protein kinase
C1703_RS27090	COG2815	serine threonine protein kinase
C1703_RS27105	COG0270	DNA (cytosine-5-)-methyltransferase activity
C1703_RS27140	COG2188	Transcriptional regulator
C1703_RS27200	COG0018	arginyl-trna synthetase
C1703_RS27205	COG0019	diaminopimelate decarboxylase activity
C1703_RS27210	COG0460	homoserine dehydrogenase
C1703_RS27215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1703_RS27220	COG0083	homoserine kinase activity
C1703_RS27240	COG0254	rRNA binding
C1703_RS27245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1703_RS27250	COG2890	protein-(glutamine-N5) methyltransferase activity
C1703_RS27260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1703_RS27265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1703_RS27270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1703_RS27285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1703_RS27290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1703_RS27295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1703_RS27300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1703_RS27305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1703_RS27310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1703_RS27315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1703_RS27330	COG2197	response regulator
C1703_RS27335	COG4585	Histidine kinase
C1703_RS27370	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1703_RS27385	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C1703_RS27420	COG1131	(ABC) transporter
C1703_RS27440	COG0183	Belongs to the thiolase family
C1703_RS27455	COG0745	RESPONSE REGULATOR receiver
C1703_RS27520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS27520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS27555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1703_RS27560	COG0280	phosphate acetyltransferase
C1703_RS27560	COG0857	belongs to the CobB CobQ family
C1703_RS27565	COG0205	6-phosphofructokinase activity
C1703_RS27580	COG1414	Transcriptional regulator
C1703_RS27585	COG2610	gluconate transmembrane transporter activity
C1703_RS27590	COG4948	Mandelate Racemase Muconate Lactonizing
C1703_RS27610	COG0395	ABC-type sugar transport system, permease component
C1703_RS27615	COG1175	transmembrane transport
C1703_RS27620	COG1653	transport
C1703_RS27625	COG4565	transcriptional regulatory protein
C1703_RS27630	COG3290	protein histidine kinase activity
C1703_RS27635	COG1301	dicarboxylic acid transport
C1703_RS27645	COG0477	Major facilitator Superfamily
C1703_RS27650	COG0667	Aldo Keto reductase
C1703_RS27660	COG1522	sequence-specific DNA binding
C1703_RS27690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1703_RS27695	COG3281	Trehalose synthase
C1703_RS27700	COG0366	Alpha amylase catalytic
C1703_RS27705	COG0366	Alpha amylase catalytic
C1703_RS27715	COG0058	SHG alpha-glucan phosphorylase activity
C1703_RS27740	COG1132	(ABC) transporter
C1703_RS27745	COG1132	(ABC) transporter
C1703_RS27750	COG1131	(ABC) transporter
C1703_RS27795	COG0789	Transcriptional regulator
C1703_RS27805	COG1119	ATPase activity
C1703_RS27810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1703_RS27825	COG0142	geranyltranstransferase activity
C1703_RS27830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1703_RS27835	COG3135	benzoate transporter
C1703_RS27860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1703_RS27865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1703_RS27880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1703_RS27885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1703_RS27910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1703_RS27920	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C1703_RS27925	COG2409	Drug exporters of the RND superfamily
C1703_RS27935	COG1760	l-serine dehydratase
C1703_RS27940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1703_RS27945	COG0509	glycine decarboxylation via glycine cleavage system
C1703_RS27950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1703_RS27970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS27985	COG0444	Belongs to the ABC transporter superfamily
C1703_RS27990	COG4608	Belongs to the ABC transporter superfamily
C1703_RS28000	COG0156	8-amino-7-oxononanoate synthase activity
C1703_RS28010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1703_RS28020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1703_RS28025	COG4946	Tricorn protease homolog
C1703_RS28025	COG0793	Belongs to the peptidase S41A family
C1703_RS28040	COG2860	membrane
C1703_RS28090	COG0482	sulfurtransferase activity
C1703_RS28110	COG1611	Belongs to the LOG family
C1703_RS28115	COG4221	oxidoreductase activity
C1703_RS28125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1703_RS28135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1703_RS28140	COG0154	amidase activity
C1703_RS28150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1703_RS28155	COG2226	methyltransferase
C1703_RS28165	COG2409	Drug exporters of the RND superfamily
C1703_RS28170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1703_RS28185	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1703_RS28185	COG1672	PFAM Archaeal ATPase
C1703_RS28195	COG2133	pyrroloquinoline quinone binding
C1703_RS28200	COG0667	Aldo Keto reductase
C1703_RS28210	COG5001	Diguanylate cyclase
C1703_RS28220	COG0440	acetolactate synthase activity
C1703_RS28225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1703_RS28235	COG0477	Major facilitator Superfamily
C1703_RS28245	COG4608	Belongs to the ABC transporter superfamily
C1703_RS28255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS28260	COG4166	transmembrane transport
C1703_RS28275	COG0506	proline dehydrogenase activity
C1703_RS28280	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS28285	COG1063	alcohol dehydrogenase
C1703_RS28305	COG0473	3-isopropylmalate dehydrogenase activity
C1703_RS28310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1703_RS28320	COG0832	Belongs to the urease beta subunit family
C1703_RS28320	COG0831	urea catabolic process
C1703_RS28325	COG0804	urea catabolic process
C1703_RS28330	COG2957	Belongs to the agmatine deiminase family
C1703_RS28345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1703_RS28385	COG2353	YceI-like domain
C1703_RS28390	COG0438	transferase activity, transferring glycosyl groups
C1703_RS28405	COG1032	radical SAM domain protein
C1703_RS28410	COG0300	oxidoreductase activity
C1703_RS28420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1703_RS28440	COG2018	Roadblock/LC7 domain
C1703_RS28460	COG2018	Roadblock/LC7 domain
C1703_RS28475	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1703_RS28480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1703_RS28520	COG1414	Transcriptional regulator
C1703_RS28525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1703_RS28530	COG0066	3-isopropylmalate dehydratase activity
C1703_RS28540	COG0776	regulation of translation
C1703_RS28550	COG1920	GTP binding
C1703_RS28560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1703_RS28565	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1703_RS28585	COG0351	phosphomethylpyrimidine kinase
C1703_RS28590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1703_RS28595	COG1461	Dihydroxyacetone kinase
C1703_RS28605	COG0326	Molecular chaperone. Has ATPase activity
C1703_RS28615	COG0742	ribosomal rna small subunit methyltransferase
C1703_RS28620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1703_RS28635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1703_RS28640	COG0571	ribonuclease III activity
C1703_RS28645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1703_RS28650	COG1733	regulation of RNA biosynthetic process
C1703_RS28660	COG2340	Cysteine-rich secretory protein family
C1703_RS28665	COG1254	Belongs to the acylphosphatase family
C1703_RS28675	COG1196	nuclear chromosome segregation
C1703_RS28680	COG0477	Major facilitator Superfamily
C1703_RS28715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1703_RS28730	COG0442	prolyl-tRNA aminoacylation
C1703_RS28740	COG0228	four-way junction DNA binding
C1703_RS28745	COG1837	Belongs to the UPF0109 family
C1703_RS28750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1703_RS28755	COG0336	Belongs to the RNA methyltransferase TrmD family
C1703_RS28760	COG0335	large ribosomal subunit rRNA binding
C1703_RS28775	COG0681	Belongs to the peptidase S26 family
C1703_RS28780	COG0681	Belongs to the peptidase S26 family
C1703_RS28785	COG1051	belongs to the nudix hydrolase family
C1703_RS28795	COG0792	nuclease activity
C1703_RS28810	COG1191	sigma factor activity
C1703_RS28820	COG4942	peptidase
C1703_RS28825	COG0052	Belongs to the universal ribosomal protein uS2 family
C1703_RS28830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1703_RS28835	COG0528	UMP kinase activity
C1703_RS28840	COG0233	cytoplasmic translational termination
C1703_RS28845	COG0575	Belongs to the CDS family
C1703_RS28855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1703_RS28865	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1703_RS28870	COG3842	ATPase activity
C1703_RS28910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1703_RS28920	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS28935	COG0584	glycerophosphoryl diester phosphodiesterase
C1703_RS28940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1703_RS28960	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS28970	COG3842	ATPase activity
C1703_RS28980	COG1177	transmembrane transport
C1703_RS28985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS29005	COG1733	regulation of RNA biosynthetic process
C1703_RS29030	COG2508	Transcriptional regulator
C1703_RS29030	COG2508	Transcriptional regulator
C1703_RS29035	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS29040	COG1472	Belongs to the glycosyl hydrolase 3 family
C1703_RS29055	COG4209	transmembrane transport
C1703_RS29060	COG0395	ABC-type sugar transport system, permease component
C1703_RS29105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1703_RS29110	COG0750	zinc metalloprotease
C1703_RS29115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1703_RS29130	COG0442	prolyl-tRNA aminoacylation
C1703_RS29150	COG0779	Required for maturation of 30S ribosomal subunits
C1703_RS29165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1703_RS29175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1703_RS29180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1703_RS29195	COG4608	Belongs to the ABC transporter superfamily
C1703_RS29205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS29210	COG0601	transmembrane transport
C1703_RS29220	COG0455	bacterial-type flagellum organization
C1703_RS29240	COG1404	Belongs to the peptidase S8 family
C1703_RS29270	COG1404	Belongs to the peptidase S8 family
C1703_RS29320	COG1674	ftsk spoiiie
C1703_RS29335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1703_RS29340	COG1185	polyribonucleotide nucleotidyltransferase activity
C1703_RS29345	COG0612	Peptidase, M16
C1703_RS29350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1703_RS29370	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C1703_RS29375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS29380	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C1703_RS29415	COG2770	Histidine kinase
C1703_RS29415	COG2208	phosphoserine phosphatase activity
C1703_RS29425	COG3437	response regulator, receiver
C1703_RS29425	COG4999	Histidine kinase
C1703_RS29425	COG2205	protein histidine kinase activity
C1703_RS29425	COG3850	Histidine kinase
C1703_RS29435	COG1674	ftsk spoiiie
C1703_RS29445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1703_RS29455	COG1058	Belongs to the CinA family
C1703_RS29455	COG1546	Belongs to the CinA family
C1703_RS29460	COG1396	sequence-specific DNA binding
C1703_RS29465	COG0783	Belongs to the Dps family
C1703_RS29475	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS29480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1703_RS29485	COG1201	RNA secondary structure unwinding
C1703_RS29515	COG0628	permease
C1703_RS29525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1703_RS29550	COG0765	amino acid transport
C1703_RS29555	COG0765	amino acid transport
C1703_RS29560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1703_RS29565	COG1126	abc transporter atp-binding protein
C1703_RS29570	COG0745	RESPONSE REGULATOR receiver
C1703_RS29575	COG2205	protein histidine kinase activity
C1703_RS29580	COG2358	TRAP transporter, solute receptor (TAXI family
C1703_RS29600	COG4585	Histidine kinase
C1703_RS29605	COG2197	response regulator
C1703_RS29610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1703_RS29630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1703_RS29640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1703_RS29645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1703_RS29655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1703_RS29670	COG1309	transcriptional regulator
C1703_RS29705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1703_RS29710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1703_RS29715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1703_RS29745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1703_RS29780	COG1131	(ABC) transporter
C1703_RS29785	COG2186	Transcriptional regulator
C1703_RS29790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1703_RS29805	COG0187	DNA topoisomerase II activity
C1703_RS29815	COG4585	Histidine kinase
C1703_RS29820	COG2197	response regulator
C1703_RS29830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1703_RS29835	COG4565	transcriptional regulatory protein
C1703_RS29845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1703_RS29855	COG4565	transcriptional regulatory protein
C1703_RS29860	COG3290	protein histidine kinase activity
C1703_RS29875	COG0372	Belongs to the citrate synthase family
C1703_RS29895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1703_RS29900	COG0612	Peptidase, M16
C1703_RS29915	COG1802	Transcriptional regulator
C1703_RS29920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1703_RS29940	COG1435	thymidine kinase activity
C1703_RS29970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1703_RS29980	COG0745	RESPONSE REGULATOR receiver
C1703_RS29985	COG2205	protein histidine kinase activity
C1703_RS30010	COG0756	dUTP diphosphatase activity
C1703_RS30050	COG0569	domain protein
C1703_RS30055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS30065	COG0531	amino acid
C1703_RS30070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1703_RS30125	COG3226	Transcriptional regulator
C1703_RS30145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1703_RS30155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1703_RS30185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS30195	COG3594	Acyltransferase
C1703_RS30215	COG0277	FAD linked oxidase domain protein
C1703_RS30215	COG0247	lactate metabolic process
C1703_RS30235	COG0243	molybdopterin cofactor binding
C1703_RS30240	COG1799	cell septum assembly
C1703_RS30275	COG2226	methyltransferase
C1703_RS30280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1703_RS30290	COG2255	four-way junction helicase activity
C1703_RS30300	COG0475	glutathione-regulated potassium exporter activity
C1703_RS30325	COG2235	arginine
C1703_RS30330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1703_RS30335	COG0531	amino acid
C1703_RS30345	COG1024	Enoyl-CoA hydratase
C1703_RS30360	COG4249	Peptidase C14 caspase catalytic subunit p20
C1703_RS30360	COG2319	Wd-40 repeat
C1703_RS30395	COG0601	transmembrane transport
C1703_RS30400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS30405	COG0444	Belongs to the ABC transporter superfamily
C1703_RS30430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1703_RS30435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1703_RS30440	COG0019	diaminopimelate decarboxylase activity
C1703_RS30460	COG0443	Heat shock 70 kDa protein
C1703_RS30480	COG2815	serine threonine protein kinase
C1703_RS30480	COG0515	serine threonine protein kinase
C1703_RS30500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1703_RS30510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1703_RS30520	COG4214	carbohydrate transport
C1703_RS30530	COG4213	ABC transporter substrate-binding protein
C1703_RS30560	COG3458	cephalosporin-C deacetylase activity
C1703_RS30565	COG4209	transmembrane transport
C1703_RS30570	COG0395	ABC-type sugar transport system, permease component
C1703_RS30605	COG1653	transport
C1703_RS30610	COG1175	transmembrane transport
C1703_RS30615	COG0395	ABC-type sugar transport system, permease component
C1703_RS30620	COG1940	carbohydrate kinase activity
C1703_RS30625	COG4213	ABC transporter substrate-binding protein
C1703_RS30635	COG4214	carbohydrate transport
C1703_RS30640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1703_RS30645	COG0531	amino acid
C1703_RS30680	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1703_RS30680	COG1024	Enoyl-CoA hydratase
C1703_RS30685	COG0183	Belongs to the thiolase family
C1703_RS30690	COG1609	Transcriptional regulator
C1703_RS30695	COG3250	beta-galactosidase activity
C1703_RS30705	COG1175	transmembrane transport
C1703_RS30710	COG3833	ABC-type maltose transport systems, permease component
C1703_RS30715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1703_RS30730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1703_RS30740	COG0673	inositol 2-dehydrogenase activity
C1703_RS30745	COG0561	phosphatase activity
C1703_RS30750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1703_RS30785	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1703_RS30795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C1703_RS30800	COG3253	May function as heme-dependent peroxidase
C1703_RS30820	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS30835	COG3220	belongs to the UPF0276 family
C1703_RS30840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1703_RS30860	COG0723	plastoquinol--plastocyanin reductase activity
C1703_RS30860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS30865	COG2326	polyphosphate kinase activity
C1703_RS30875	COG0330	HflC and HflK could
C1703_RS30885	COG0288	reversible hydration of carbon dioxide
C1703_RS30910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1703_RS30915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1703_RS30920	COG1472	Belongs to the glycosyl hydrolase 3 family
C1703_RS30945	COG0395	ABC-type sugar transport system, permease component
C1703_RS30950	COG1175	transmembrane transport
C1703_RS30970	COG1737	Transcriptional regulator
C1703_RS30975	COG4821	SIS domain
C1703_RS31010	COG1175	transmembrane transport
C1703_RS31015	COG0395	ABC-type sugar transport system, permease component
C1703_RS31020	COG1874	Beta-galactosidase
C1703_RS31035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1703_RS31040	COG0019	diaminopimelate decarboxylase activity
C1703_RS31055	COG0747	negative chemotaxis
C1703_RS31060	COG0601	transmembrane transport
C1703_RS31095	COG0745	RESPONSE REGULATOR receiver
C1703_RS31100	COG2205	protein histidine kinase activity
C1703_RS31110	COG1174	glycine betaine transport
C1703_RS31115	COG1174	glycine betaine transport
C1703_RS31155	COG0640	Transcriptional regulator
C1703_RS31160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1703_RS31165	COG1316	TRANSCRIPTIONal
C1703_RS31195	COG1404	Belongs to the peptidase S8 family
C1703_RS31200	COG1309	transcriptional regulator
C1703_RS31220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1703_RS31255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1703_RS31260	COG0583	DNA-binding transcription factor activity
C1703_RS31350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1703_RS31355	COG1116	anion transmembrane transporter activity
C1703_RS31380	COG0529	Catalyzes the synthesis of activated sulfate
C1703_RS31385	COG0175	sulfate reduction
C1703_RS31415	COG1960	acyl-CoA dehydrogenase activity
C1703_RS31430	COG1917	Cupin 2, conserved barrel domain protein
C1703_RS31430	COG4977	sequence-specific DNA binding
C1703_RS31445	COG1132	(ABC) transporter
C1703_RS31495	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS31505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1703_RS31505	COG3321	synthase
C1703_RS31560	COG0395	ABC-type sugar transport system, permease component
C1703_RS31565	COG1175	transmembrane transport
C1703_RS31590	COG1175	transmembrane transport
C1703_RS31595	COG0395	ABC-type sugar transport system, permease component
C1703_RS31625	COG0644	oxidoreductase
C1703_RS31635	COG1609	Transcriptional regulator
C1703_RS31645	COG2040	homocysteine
C1703_RS31650	COG0531	amino acid
C1703_RS31665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1703_RS31705	COG2755	lipolytic protein G-D-S-L family
C1703_RS31715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1703_RS31775	COG1131	(ABC) transporter
C1703_RS31785	COG0395	ABC-type sugar transport system, permease component
C1703_RS31790	COG1175	transmembrane transport
C1703_RS31800	COG1940	carbohydrate kinase activity
C1703_RS31815	COG0277	FAD linked oxidase domain protein
C1703_RS31820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1703_RS31835	COG1162	GTPase activity
C1703_RS31845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1703_RS31860	COG0028	Belongs to the TPP enzyme family
C1703_RS31955	COG1802	Transcriptional regulator
C1703_RS31960	COG0789	Transcriptional regulator
C1703_RS32015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1703_RS32020	COG2252	PERMEase
C1703_RS32025	COG3608	succinylglutamate desuccinylase aspartoacylase
C1703_RS32025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1703_RS32045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1703_RS32050	COG2192	nodulation
C1703_RS32060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1703_RS32065	COG0859	PFAM glycosyl transferase family 9
C1703_RS32075	COG0297	glycogen (starch) synthase activity
C1703_RS32080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1703_RS32085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1703_RS32085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1703_RS32115	COG3940	Belongs to the glycosyl hydrolase 43 family
C1703_RS32130	COG1609	Transcriptional regulator
C1703_RS32135	COG1653	transport
C1703_RS32150	COG0366	Alpha amylase catalytic
C1703_RS32165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1703_RS32170	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1703_RS32175	COG0137	argininosuccinate synthase activity
C1703_RS32215	COG0745	RESPONSE REGULATOR receiver
C1703_RS32220	COG5002	protein histidine kinase activity
C1703_RS32250	COG1309	transcriptional regulator
C1703_RS32275	COG2268	Band 7 protein
C1703_RS32300	COG0598	Magnesium transport protein CorA
C1703_RS32305	COG2267	carboxylic ester hydrolase activity
C1703_RS32340	COG0657	acetylesterase activity
C1703_RS32360	COG2814	Major facilitator Superfamily
C1703_RS32365	COG3619	membrane
C1703_RS32370	COG2259	Doxx family
C1703_RS32375	COG1335	isochorismatase
C1703_RS32400	COG0582	viral genome integration into host DNA
C1703_RS32405	COG0598	Magnesium transport protein CorA
C1703_RS32425	COG2197	response regulator
C1703_RS32430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1703_RS32435	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS32450	COG3960	tartronate-semialdehyde synthase activity
C1703_RS32465	COG0753	catalase activity
C1703_RS32470	COG2084	Dehydrogenase
C1703_RS32475	COG3622	Belongs to the hyi family
C1703_RS32525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1703_RS32530	COG1127	ABC transporter
C1703_RS32560	COG2351	hydroxyisourate hydrolase activity
C1703_RS32575	COG2233	PERMEase
C1703_RS32590	COG0436	Aminotransferase
C1703_RS32595	COG1733	regulation of RNA biosynthetic process
C1703_RS32610	COG4264	IucA IucC family
C1703_RS32640	COG1120	ATPase activity
C1703_RS32645	COG2814	Major facilitator Superfamily
C1703_RS32655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS32660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1703_RS32670	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS32680	COG2345	Transcriptional regulator
C1703_RS32700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1703_RS32705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1703_RS32715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1703_RS32740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1703_RS32755	COG4770	biotin carboxylase activity
C1703_RS32760	COG0745	RESPONSE REGULATOR receiver
C1703_RS32765	COG2814	Major facilitator Superfamily
C1703_RS32805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1703_RS32825	COG1414	Transcriptional regulator
C1703_RS32830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1703_RS32835	COG4266	Belongs to the allantoicase family
C1703_RS32840	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS32900	COG2197	response regulator
C1703_RS32905	COG0673	inositol 2-dehydrogenase activity
C1703_RS32915	COG1940	carbohydrate kinase activity
C1703_RS32925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1703_RS32955	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS32970	COG1177	transmembrane transport
C1703_RS32980	COG3842	ATPase activity
C1703_RS33005	COG0277	FAD linked oxidase domain protein
C1703_RS33005	COG0247	lactate metabolic process
C1703_RS33010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS33025	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS33035	COG3345	alpha-galactosidase
C1703_RS33055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1703_RS33060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1703_RS33080	COG1126	abc transporter atp-binding protein
C1703_RS33085	COG2936	dipeptidyl-peptidase activity
C1703_RS33095	COG0405	Gamma-glutamyltransferase
C1703_RS33100	COG0542	response to heat
C1703_RS33125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1703_RS33140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1703_RS33150	COG1953	Uracil, thiamine, allantoin
C1703_RS33165	COG0483	inositol monophosphate 1-phosphatase activity
C1703_RS33180	COG0121	glutamine amidotransferase
C1703_RS33185	COG0488	(ABC) transporter
C1703_RS33205	COG2814	Major facilitator Superfamily
C1703_RS33210	COG0640	Transcriptional regulator
C1703_RS33225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1703_RS33240	COG1929	Belongs to the glycerate kinase type-1 family
C1703_RS33250	COG0688	phosphatidylethanolamine metabolic process
C1703_RS33255	COG1960	acyl-CoA dehydrogenase activity
C1703_RS33265	COG2301	Belongs to the HpcH HpaI aldolase family
C1703_RS33270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS33270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1703_RS33275	COG0604	alcohol dehydrogenase
C1703_RS33285	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1703_RS33305	COG0596	Alpha beta hydrolase
C1703_RS33320	COG2814	Major facilitator Superfamily
C1703_RS33325	COG1366	Belongs to the anti-sigma-factor antagonist family
C1703_RS33325	COG2208	phosphoserine phosphatase activity
C1703_RS33325	COG2172	sigma factor antagonist activity
C1703_RS33330	COG2226	methyltransferase
C1703_RS33335	COG2755	lipolytic protein G-D-S-L family
C1703_RS33340	COG2362	D-Aminopeptidase
C1703_RS33345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1703_RS33350	COG4946	Tricorn protease homolog
C1703_RS33350	COG0823	Involved in the tonB-independent uptake of proteins
C1703_RS33350	COG1506	peptidase
C1703_RS33355	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1703_RS33380	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS33390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS33470	COG1597	lipid kinase activity
C1703_RS33480	COG0488	(ABC) transporter
C1703_RS33500	COG0693	protein deglycase activity
C1703_RS33510	COG0517	IMP dehydrogenase activity
C1703_RS33510	COG0516	GMP reductase activity
C1703_RS33525	COG0028	Belongs to the TPP enzyme family
C1703_RS33595	COG0443	Heat shock 70 kDa protein
C1703_RS33620	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1703_RS33625	COG4106	trans-aconitate 2-methyltransferase activity
C1703_RS33625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1703_RS33635	COG2378	regulation of single-species biofilm formation
C1703_RS33645	COG4733	cellulase activity
C1703_RS33645	COG5297	Belongs to the glycosyl hydrolase family 6
C1703_RS33650	COG5297	Belongs to the glycosyl hydrolase family 6
C1703_RS33660	COG0656	L-ascorbic acid biosynthetic process
C1703_RS33700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1703_RS33710	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1703_RS33715	COG3383	formate dehydrogenase (NAD+) activity
C1703_RS33720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1703_RS33730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1703_RS33740	COG2050	protein possibly involved in aromatic compounds catabolism
C1703_RS33745	COG1940	carbohydrate kinase activity
C1703_RS33750	COG1129	ABC transporter
C1703_RS33755	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1703_RS33765	COG0673	inositol 2-dehydrogenase activity
C1703_RS33785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1703_RS33825	COG2223	nitrite transmembrane transporter activity
C1703_RS33835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1703_RS33845	COG0045	succinate-CoA ligase (ADP-forming) activity
C1703_RS33855	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS33870	COG2814	Major facilitator Superfamily
C1703_RS33890	COG3284	Transcriptional regulator
C1703_RS33900	COG3485	protocatechuate 3,4-dioxygenase
C1703_RS33905	COG1454	alcohol dehydrogenase
C1703_RS33910	COG0702	epimerase
C1703_RS33915	COG2353	YceI-like domain
C1703_RS33920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1703_RS33950	COG0747	negative chemotaxis
C1703_RS33955	COG0251	oxidation-reduction process
C1703_RS33960	COG1733	regulation of RNA biosynthetic process
C1703_RS33980	COG0297	glycogen (starch) synthase activity
C1703_RS34000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1703_RS34020	COG0640	Transcriptional regulator
C1703_RS34025	COG0346	lactoylglutathione lyase activity
C1703_RS34030	COG0346	lactoylglutathione lyase activity
C1703_RS34035	COG0477	Major facilitator Superfamily
C1703_RS34045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1703_RS34050	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C1703_RS34050	COG1082	Xylose isomerase domain protein TIM barrel
C1703_RS34060	COG0406	alpha-ribazole phosphatase activity
C1703_RS34065	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C1703_RS34070	COG0166	Belongs to the GPI family
C1703_RS34085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1703_RS34090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1703_RS34125	COG0477	Major facilitator Superfamily
C1703_RS34135	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS34165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1703_RS34170	COG3250	beta-galactosidase activity
C1703_RS34175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1703_RS34205	COG1486	melibiose metabolic process
C1703_RS34225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1703_RS34290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1703_RS34305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS34310	COG3938	Belongs to the proline racemase family
C1703_RS34320	COG1116	anion transmembrane transporter activity
C1703_RS34325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1703_RS34330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1703_RS34335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1703_RS34390	COG0456	acetyltransferase
C1703_RS34405	COG0477	Major facilitator Superfamily
C1703_RS34410	COG3511	phospholipase C
C1703_RS34455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1703_RS34460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1703_RS34465	COG3485	protocatechuate 3,4-dioxygenase
C1703_RS34470	COG3485	protocatechuate 3,4-dioxygenase
C1703_RS34490	COG1846	Transcriptional regulator
C1703_RS34505	COG1793	dna ligase
C1703_RS34550	COG1834	amidinotransferase
C1703_RS34570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1703_RS34575	COG0488	(ABC) transporter
C1703_RS34600	COG1515	deoxyribonuclease V activity
C1703_RS34605	COG3268	Saccharopine dehydrogenase
C1703_RS34615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1703_RS34620	COG0183	Belongs to the thiolase family
C1703_RS34625	COG1024	Enoyl-CoA hydratase
C1703_RS34625	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1703_RS34635	COG1113	amino acid transport
C1703_RS34650	COG2936	dipeptidyl-peptidase activity
C1703_RS34660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1703_RS34675	COG0488	(ABC) transporter
C1703_RS34685	COG2183	response to ionizing radiation
C1703_RS34705	COG1024	Enoyl-CoA hydratase
C1703_RS34715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1703_RS34760	COG1134	teichoic acid transport
C1703_RS34765	COG1562	ergosterol biosynthetic process
C1703_RS34775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C1703_RS34785	COG1657	PFAM Prenyltransferase squalene oxidase
C1703_RS34800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1703_RS34805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1703_RS34825	COG2365	Tyrosine phosphatase family
C1703_RS34845	COG2755	lipolytic protein G-D-S-L family
C1703_RS34885	COG1063	alcohol dehydrogenase
C1703_RS34890	COG0156	8-amino-7-oxononanoate synthase activity
C1703_RS34895	COG0583	DNA-binding transcription factor activity
C1703_RS34915	COG3958	Transketolase
C1703_RS34920	COG3959	Transketolase, thiamine diphosphate binding domain
C1703_RS34930	COG3401	FG-GAP repeat protein
C1703_RS34935	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C1703_RS34955	COG2197	response regulator
C1703_RS34965	COG4585	Histidine kinase
C1703_RS34975	COG0006	proline dipeptidase activity
C1703_RS34980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1703_RS34985	COG0022	dehydrogenase e1 component
C1703_RS34990	COG0402	S-adenosylhomocysteine deaminase activity
C1703_RS35000	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS35025	COG0183	Belongs to the thiolase family
C1703_RS35035	COG1011	Hydrolase
C1703_RS35070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1703_RS35075	COG0494	nUDIX hydrolase
C1703_RS35105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1703_RS35110	COG1316	TRANSCRIPTIONal
C1703_RS35140	COG0489	protein tyrosine kinase activity
C1703_RS35155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1703_RS35170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1703_RS35190	COG3387	PFAM Glycoside hydrolase 15-related
C1703_RS35195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1703_RS35200	COG2188	Transcriptional regulator
C1703_RS35210	COG3962	Belongs to the TPP enzyme family
C1703_RS35215	COG3718	enzyme involved in inositol metabolism
C1703_RS35225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS35245	COG1312	Catalyzes the dehydration of D-mannonate
C1703_RS35250	COG0673	inositol 2-dehydrogenase activity
C1703_RS35260	COG0673	inositol 2-dehydrogenase activity
C1703_RS35275	COG1609	Transcriptional regulator
C1703_RS35280	COG3548	integral membrane protein
C1703_RS35285	COG0673	inositol 2-dehydrogenase activity
C1703_RS35315	COG1653	transport
C1703_RS35345	COG2197	response regulator
C1703_RS35370	COG2124	cytochrome p450
C1703_RS35380	COG2838	Isocitrate dehydrogenase
C1703_RS35385	COG0668	transmembrane transport
C1703_RS35395	COG1132	(ABC) transporter
C1703_RS35405	COG3290	protein histidine kinase activity
C1703_RS35410	COG4565	transcriptional regulatory protein
C1703_RS35430	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C1703_RS35440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1703_RS35460	COG0297	glycogen (starch) synthase activity
C1703_RS35465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1703_RS35505	COG0154	amidase activity
C1703_RS35515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1703_RS35520	COG2186	Transcriptional regulator
C1703_RS35525	COG1879	ABC-type sugar transport system periplasmic component
C1703_RS35530	COG1129	ABC transporter
C1703_RS35540	COG4948	Mandelate Racemase Muconate Lactonizing
C1703_RS35545	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS35560	COG3618	amidohydrolase
C1703_RS35580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1703_RS35585	COG2770	Histidine kinase
C1703_RS35585	COG2208	phosphoserine phosphatase activity
C1703_RS35615	COG0726	polysaccharide deacetylase
C1703_RS35680	COG0583	DNA-binding transcription factor activity
C1703_RS35690	COG1053	succinate dehydrogenase
C1703_RS35695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1703_RS35715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS35725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1703_RS35750	COG3360	Dodecin
C1703_RS35755	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C1703_RS35760	COG0121	glutamine amidotransferase
C1703_RS35765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1703_RS35785	COG2268	Band 7 protein
C1703_RS35820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1703_RS35875	COG0765	amino acid transport
C1703_RS35880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1703_RS35900	COG1126	abc transporter atp-binding protein
C1703_RS35905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1703_RS35935	COG0515	serine threonine protein kinase
C1703_RS35955	COG4991	sh3 domain protein
C1703_RS35970	COG1881	PFAM PEBP family protein
C1703_RS35975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1703_RS35995	COG4977	sequence-specific DNA binding
C1703_RS36005	COG1053	succinate dehydrogenase
C1703_RS36005	COG3976	FMN-binding domain protein
C1703_RS36025	COG2329	Antibiotic biosynthesis monooxygenase
C1703_RS36045	COG0583	DNA-binding transcription factor activity
C1703_RS36055	COG2080	2 iron, 2 sulfur cluster binding
C1703_RS36060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1703_RS36065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1703_RS36085	COG1609	Transcriptional regulator
C1703_RS36095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1703_RS36100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1703_RS36105	COG0488	(ABC) transporter
C1703_RS36110	COG0242	peptide deformylase activity
C1703_RS36145	COG2197	response regulator
C1703_RS36150	COG4585	Histidine kinase
C1703_RS36160	COG1131	(ABC) transporter
C1703_RS36180	COG1609	Transcriptional regulator
C1703_RS36205	COG2409	Drug exporters of the RND superfamily
C1703_RS36225	COG2186	Transcriptional regulator
C1703_RS36235	COG1129	ABC transporter
C1703_RS36245	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1703_RS36250	COG4948	Mandelate Racemase Muconate Lactonizing
C1703_RS36255	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS36265	COG3254	rhamnose metabolic process
C1703_RS36270	COG0247	lactate metabolic process
C1703_RS36275	COG1139	Iron-sulfur cluster binding protein
C1703_RS36280	COG1556	Lactate utilization protein
C1703_RS36300	COG5297	Belongs to the glycosyl hydrolase family 6
C1703_RS36300	COG4733	cellulase activity
C1703_RS36305	COG5297	Belongs to the glycosyl hydrolase family 6
C1703_RS36325	COG3507	Belongs to the glycosyl hydrolase 43 family
C1703_RS36335	COG4209	transmembrane transport
C1703_RS36340	COG0395	ABC-type sugar transport system, permease component
C1703_RS36380	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1703_RS36390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1703_RS36405	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1703_RS36440	COG2814	Major facilitator Superfamily
C1703_RS36445	COG1063	alcohol dehydrogenase
C1703_RS36470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1703_RS36480	COG1063	alcohol dehydrogenase
C1703_RS36495	COG0402	S-adenosylhomocysteine deaminase activity
C1703_RS36515	COG0477	Major facilitator Superfamily
C1703_RS36545	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1703_RS36550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1703_RS36555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1703_RS36590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1703_RS36610	COG0500	methyltransferase
C1703_RS36615	COG4981	capsule polysaccharide biosynthetic process
C1703_RS36650	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS36650	COG2030	dehydratase
C1703_RS36655	COG1408	metallophosphoesterase
C1703_RS36680	COG0477	Major facilitator Superfamily
C1703_RS36710	COG0673	inositol 2-dehydrogenase activity
C1703_RS36715	COG1609	Transcriptional regulator
C1703_RS36730	COG1609	Transcriptional regulator
C1703_RS36745	COG1175	transmembrane transport
C1703_RS36750	COG0395	ABC-type sugar transport system, permease component
C1703_RS36755	COG4977	sequence-specific DNA binding
C1703_RS36770	COG1131	(ABC) transporter
C1703_RS36785	COG1063	alcohol dehydrogenase
C1703_RS36790	COG1414	Transcriptional regulator
C1703_RS36795	COG0129	dihydroxy-acid dehydratase activity
C1703_RS36800	COG0523	cobalamin synthesis protein
C1703_RS36810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1703_RS36820	COG3655	Transcriptional regulator
C1703_RS36850	COG0326	Molecular chaperone. Has ATPase activity
C1703_RS36890	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1703_RS36895	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1703_RS36900	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1703_RS36915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1703_RS36920	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS36925	COG0596	Alpha beta hydrolase
C1703_RS36930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1703_RS36940	COG1132	(ABC) transporter
C1703_RS36955	COG0596	Alpha beta hydrolase
C1703_RS36970	COG1122	ATPase activity
C1703_RS36975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C1703_RS36980	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
C1703_RS36985	COG0310	cobalt ion transport
C1703_RS37005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1703_RS37025	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS37050	COG0174	glutamine synthetase
C1703_RS37065	COG4689	acetoacetate decarboxylase
C1703_RS37085	COG1309	transcriptional regulator
C1703_RS37095	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS37100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1703_RS37105	COG1846	Transcriptional regulator
C1703_RS37140	COG1121	(ABC) transporter
C1703_RS37145	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1703_RS37170	COG0542	response to heat
C1703_RS37180	COG1136	(ABC) transporter
C1703_RS37195	COG1556	Lactate utilization protein
C1703_RS37200	COG1139	Iron-sulfur cluster binding protein
C1703_RS37205	COG0247	lactate metabolic process
C1703_RS37210	COG1070	Carbohydrate kinase
C1703_RS37215	COG3347	Dehydrogenase
C1703_RS37215	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS37225	COG1129	ABC transporter
C1703_RS37230	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1703_RS37235	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1703_RS37240	COG1879	ABC-type sugar transport system periplasmic component
C1703_RS37255	COG1609	Transcriptional regulator
C1703_RS37270	COG1595	DNA-templated transcription, initiation
C1703_RS37275	COG1357	PFAM Pentapeptide repeats (8 copies)
C1703_RS37285	COG1309	transcriptional regulator
C1703_RS37295	COG2706	6-phosphogluconolactonase activity
C1703_RS37350	COG1796	DNA polymerase
C1703_RS37350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1703_RS37355	COG1028	Short-chain dehydrogenase reductase Sdr
C1703_RS37390	COG1012	belongs to the aldehyde dehydrogenase family
C1703_RS37415	COG3507	Belongs to the glycosyl hydrolase 43 family
C1703_RS37435	COG4989	oxidoreductase activity
C1703_RS37500	COG0435	Glutathione S-transferase
C1703_RS37520	COG2124	cytochrome p450
C1703_RS37550	COG0667	Aldo Keto reductase
C1703_RS37580	COG3250	beta-galactosidase activity
C1703_RS37595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1703_RS37645	COG2890	protein-(glutamine-N5) methyltransferase activity
C1703_RS37660	COG0248	Ppx GppA phosphatase
C1703_RS37665	COG2274	protein secretion by the type I secretion system
C1703_RS37695	COG2197	response regulator
C1703_RS37705	COG1132	(ABC) transporter
C1703_RS37715	COG0515	serine threonine protein kinase
C1703_RS37725	COG0517	IMP dehydrogenase activity
C1703_RS37775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1703_RS37805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1703_RS37825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1703_RS37865	COG1132	(ABC) transporter
C1703_RS37895	COG2182	Extracellular solute-binding protein
C1703_RS37905	COG1175	transmembrane transport
C1703_RS37910	COG1940	carbohydrate kinase activity
C1703_RS37910	COG1846	Transcriptional regulator
C1703_RS37935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1703_RS37945	COG0673	inositol 2-dehydrogenase activity
C1703_RS38010	COG1940	carbohydrate kinase activity
C1703_RS38020	COG1175	transmembrane transport
C1703_RS38025	COG0395	ABC-type sugar transport system, permease component
C1703_RS38060	COG1554	hydrolase, family 65, central catalytic
C1703_RS38070	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1703_RS38075	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C1703_RS38110	COG0673	inositol 2-dehydrogenase activity
C1703_RS38115	COG3973	AAA domain
C1703_RS38120	COG1082	Xylose isomerase domain protein TIM barrel
C1703_RS38125	COG0673	inositol 2-dehydrogenase activity
C1703_RS38130	COG2814	Major facilitator Superfamily
C1703_RS38145	COG3962	Belongs to the TPP enzyme family
C1703_RS38155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1703_RS38160	COG1609	Transcriptional regulator
C1703_RS38170	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C1703_RS38195	COG3693	PFAM glycoside hydrolase, family 10
C1703_RS38195	COG3507	Belongs to the glycosyl hydrolase 43 family
C1703_RS38195	COG2382	esterase
C1703_RS38200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1703_RS38200	COG3321	synthase
C1703_RS38205	COG0318	PFAM AMP-dependent synthetase and ligase
C1703_RS38210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1703_RS38215	COG0667	Aldo Keto reductase
C1703_RS38270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1703_RS38275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1703_RS38280	COG2080	2 iron, 2 sulfur cluster binding
C1703_RS38300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1703_RS38305	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1703_RS38310	COG2208	phosphoserine phosphatase activity
C1703_RS38320	COG2205	protein histidine kinase activity
C1703_RS38320	COG5002	protein histidine kinase activity
C1703_RS38320	COG0784	Response regulator, receiver
C1703_RS38330	COG1335	isochorismatase
C1703_RS38365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1703_RS38435	COG0596	Alpha beta hydrolase
C1703_RS38450	COG1595	DNA-templated transcription, initiation
C1703_RS38460	COG3290	protein histidine kinase activity
C1703_RS38510	COG4608	Belongs to the ABC transporter superfamily
C1703_RS38530	COG0747	negative chemotaxis
C1703_RS38580	COG0438	transferase activity, transferring glycosyl groups
C1703_RS38590	COG2353	YceI-like domain
C1703_RS38635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1703_RS38640	COG0640	Transcriptional regulator
C1703_RS38645	COG0798	PFAM Bile acid sodium symporter
C1703_RS38650	COG1695	Transcriptional regulator
C1703_RS38660	COG0640	Transcriptional regulator
C1703_RS38670	COG2197	response regulator
C1703_RS38675	COG4585	Histidine kinase
C1703_RS38720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1703_RS38735	COG4941	Belongs to the sigma-70 factor family
C1703_RS38740	COG3795	YCII-related domain
C1703_RS38760	COG4977	sequence-specific DNA binding
C1703_RS38780	COG2226	methyltransferase
C1703_RS38820	COG2409	Drug exporters of the RND superfamily
C1703_RS38825	COG2197	response regulator