locus-tag class description GR129_RS00020 ENOG4108MWI inositol mono-phosphatase GR129_RS00035 ENOG4106A3M Cytochrome p-450 GR129_RS00040 ENOG4108VUG Enoyl-CoA hydratase GR129_RS00045 ENOG4105DKW ABC transporter GR129_RS00070 ENOG4105BZU Histidine kinase GR129_RS00105 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GR129_RS00135 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GR129_RS00140 ENOG4105CV8 reductase GR129_RS00145 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR129_RS00165 ENOG4105C57 major facilitator superfamily GR129_RS00185 ENOG4107RCI amp-dependent synthetase and ligase GR129_RS00215 ENOG4105VCQ rubredoxin GR129_RS00220 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR129_RS00230 ENOG41067SE Tetr family transcriptional regulator GR129_RS00255 ENOG4105CAQ asparagine synthetase GR129_RS00320 ENOG4105XEA Tetr family transcriptional regulator GR129_RS00440 ENOG4105E5W Transporter GR129_RS00480 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GR129_RS00500 ENOG4105KVH Transcriptional regulator GR129_RS00510 ENOG4108Z40 Transcriptional regulator GR129_RS00515 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GR129_RS00535 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS00570 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GR129_RS00625 ENOG41062D9 Histidine kinase GR129_RS00685 ENOG4106S2D Transcriptional regulator GR129_RS00700 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) GR129_RS00705 ENOG4105CI2 imidazolone-5-propionate hydrolase GR129_RS00710 ENOG4105VEQ Cold shock protein GR129_RS00790 ENOG4105CAQ asparagine synthetase GR129_RS00805 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GR129_RS00810 ENOG4105ETS cytosine purines uracil thiamine allantoin GR129_RS00865 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GR129_RS00870 ENOG4105EHG Permease protein GR129_RS00895 ENOG4105MVE transcriptional regulator GR129_RS00920 ENOG4105K6V RNA polymerase GR129_RS00925 ENOG4105RNG membrane GR129_RS00935 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GR129_RS00940 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GR129_RS00985 ENOG4105EBM Alpha Beta Hydrolase Fold protein GR129_RS01010 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS01060 ENOG4105U5Y Transcriptional regulator GR129_RS01065 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GR129_RS01105 ENOG4106YKD Cytochrome p-450 GR129_RS01190 ENOG41085A6 mbth domain-containing protein GR129_RS01210 ENOG4106A3M Cytochrome p-450 GR129_RS01220 ENOG4105CG3 alpha amylase, catalytic region GR129_RS01225 ENOG4105I1K ABC transporter GR129_RS01230 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GR129_RS01250 ENOG4107MVR Transcriptional regulator GR129_RS01255 ENOG4105CQB FAD linked oxidase domain protein GR129_RS01260 ENOG4105KVH Transcriptional regulator GR129_RS01280 ENOG4105CSH Transporter GR129_RS01310 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein GR129_RS01315 ENOG4107S9F NmrA family GR129_RS01345 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GR129_RS01350 ENOG4105CVK Glutamate decarboxylase GR129_RS01355 ENOG4105EWK phytoene GR129_RS01360 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GR129_RS01375 ENOG4105E0A ABC, transporter GR129_RS01380 ENOG4105EHG Permease protein GR129_RS01410 ENOG4105WQI isochorismatase GR129_RS01415 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS01460 ENOG4105D9G High-affinity GR129_RS01480 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR129_RS01520 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GR129_RS01540 ENOG4107Z3H Transcriptional regulator, TetR family GR129_RS01580 ENOG4108KEZ Dehydrogenase GR129_RS01610 ENOG4105VEQ Cold shock protein GR129_RS01625 ENOG4105CBC glutamate synthase GR129_RS01640 ENOG4105ECQ AraC Family Transcriptional Regulator GR129_RS01655 ENOG4105BZU Histidine kinase GR129_RS01660 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS01665 ENOG41062B0 ABC transporter, permease GR129_RS01670 ENOG4105CNN ABC, transporter GR129_RS01690 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS01700 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GR129_RS01765 ENOG41069M3 Transcriptional regulator GR129_RS01770 ENOG4105EQX glucarate dehydratase GR129_RS01780 ENOG4105E9Z Nad-dependent epimerase dehydratase GR129_RS01845 ENOG4105EQK -acetyltransferase GR129_RS01885 ENOG41080V3 Major Facilitator superfamily GR129_RS01925 ENOG4105CSA Coproporphyrinogen iii oxidase GR129_RS01945 ENOG4105CMR udp-glucose 4-epimerase GR129_RS01980 ENOG4105D5P Methylmalonyl-coA mutase GR129_RS01985 ENOG4107R16 Multicopper oxidase GR129_RS01995 ENOG4105CAQ asparagine synthetase GR129_RS02050 ENOG4107ZBN O-methyltransferase GR129_RS02065 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GR129_RS02085 ENOG4107UVD Beta-phosphoglucomutase family hydrolase GR129_RS02100 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GR129_RS02125 ENOG4108JCI Transcriptional regulator GR129_RS02155 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GR129_RS02160 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GR129_RS02180 ENOG4107TE5 Lipid kinase GR129_RS02215 ENOG4105BZ1 (ABC) transporter GR129_RS02230 ENOG4108NNZ chitinase GR129_RS02260 ENOG4108VQR secreted hydrolase GR129_RS02290 ENOG4105DBE peroxidase GR129_RS02320 ENOG4105CI2 imidazolone-5-propionate hydrolase GR129_RS02330 ENOG4108YV4 Universal stress protein GR129_RS02335 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GR129_RS02360 ENOG4108KB2 LysR family Transcriptional regulator GR129_RS02400 ENOG4106HK8 GPR1 FUN34 yaaH family protein GR129_RS02430 ENOG4108TCJ secreted hydrolase GR129_RS02465 ENOG4105C7W Xanthine dehydrogenase GR129_RS02470 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GR129_RS02475 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GR129_RS02490 ENOG4108Q50 Histidine kinase GR129_RS02495 ENOG4105CJN penicillin-binding protein GR129_RS02505 ENOG4105BZU Histidine kinase GR129_RS02510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR129_RS02545 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GR129_RS02555 ENOG4105BZ9 Cytochrome C oxidase, subunit I GR129_RS02575 ENOG4105EYF MMPL domain protein GR129_RS02580 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GR129_RS02585 ENOG41064MX Tetr family transcriptional regulator GR129_RS02590 ENOG4105ECP epimerase GR129_RS02605 ENOG4107TB5 TRANSCRIPTIONal GR129_RS02610 ENOG41082SX arsR family transcriptional regulator GR129_RS02665 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GR129_RS02685 ENOG4107QRI Phosphoketolase GR129_RS02700 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GR129_RS02715 ENOG41080XP Cbs domain GR129_RS02720 ENOG4108YV4 Universal stress protein GR129_RS02735 ENOG4108PJD permease GR129_RS02770 ENOG4105DPX Hydrogenase, large subunit GR129_RS02805 ENOG4105CQS hydrogenase expression formation protein HypD GR129_RS02820 ENOG4107RSS Hydrogenase accessory protein HypB GR129_RS02825 ENOG4108USZ hydrogenase GR129_RS02835 ENOG4105KT7 mgtC SapB transporter GR129_RS02890 ENOG4108IAJ Nad-dependent epimerase dehydratase GR129_RS02900 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GR129_RS02940 ENOG4105CPC Aldo Keto reductase GR129_RS02955 ENOG4108VHT MarR family transcriptional regulator GR129_RS02970 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GR129_RS02980 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GR129_RS02985 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GR129_RS02990 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GR129_RS03005 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GR129_RS03085 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GR129_RS03090 ENOG4108RWI nicotinamidase GR129_RS03120 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GR129_RS03135 ENOG4107RTD sua5 ycio yrdc ywlc family protein GR129_RS03175 ENOG4105CV8 reductase GR129_RS03190 ENOG4108MJI response regulator GR129_RS03215 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GR129_RS03220 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GR129_RS03270 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GR129_RS03280 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GR129_RS03285 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GR129_RS03290 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GR129_RS03305 ENOG4105CEP NADH dehydrogenase GR129_RS03360 ENOG4105BZU Histidine kinase GR129_RS03380 ENOG4105K78 MarR family Transcriptional regulator GR129_RS03400 ENOG4105C5X domain protein GR129_RS03415 ENOG4105CUX Signal transduction histidine kinase GR129_RS03445 ENOG4105C7B Threonine dehydratase GR129_RS03450 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GR129_RS03455 ENOG4105KF0 sporulation and cell division protein, SsgA GR129_RS03470 ENOG4107SET aldo keto reductase GR129_RS03475 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GR129_RS03495 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS03520 ENOG4105CPC Aldo Keto reductase GR129_RS03525 ENOG4108M0I Transcriptional regulator GR129_RS03535 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GR129_RS03560 ENOG4107QTZ amino acid GR129_RS03610 ENOG4105CAQ asparagine synthetase GR129_RS03640 ENOG4105KF0 sporulation and cell division protein, SsgA GR129_RS03695 ENOG4105E39 Enoyl-CoA hydratase GR129_RS03745 ENOG4108U3T pfkb domain protein GR129_RS03755 ENOG4107QM2 Aldo Keto reductase GR129_RS03765 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GR129_RS03775 ENOG4105X7H acyl-CoA dehydrogenase GR129_RS03800 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GR129_RS03805 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GR129_RS03810 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GR129_RS03815 ENOG4105CPK Glycosyl transferase (Group 1 GR129_RS03825 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GR129_RS03845 ENOG4108IAJ Nad-dependent epimerase dehydratase GR129_RS03855 ENOG4105EC2 ftsk spoIIIe GR129_RS03880 ENOG4106F1P AAA ATPase, central domain protein GR129_RS03920 ENOG4105CMT Dihydroxyacetone kinase GR129_RS03925 ENOG4108UTZ Dihydroxyacetone kinase GR129_RS03940 ENOG4105CYP glycoside hydrolase, family GR129_RS03955 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GR129_RS03980 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR129_RS04040 ENOG4108VJY integral membrane protein GR129_RS04045 ENOG41090CE integral membrane protein GR129_RS04050 ENOG4105CSV Glutaminase GR129_RS04055 ENOG4108IJ0 Aspartate ammonia-lyase GR129_RS04070 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GR129_RS04080 ENOG4105KJJ Uncharacterized ACR, COG1993 GR129_RS04120 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GR129_RS04155 ENOG41086KC Transcriptional regulator GR129_RS04160 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GR129_RS04170 ENOG4106UDK Cellulose-binding, family II GR129_RS04210 ENOG4105BZU Histidine kinase GR129_RS04220 ENOG4105DBV ornithine carbamoyltransferase GR129_RS04225 ENOG4105CEU Arginine dihydrolase GR129_RS04230 ENOG4105D5Q Arginine ornithine antiporter GR129_RS04250 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GR129_RS04270 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GR129_RS04275 ENOG4105CKK Glycosyl transferase, family 2 GR129_RS04300 ENOG4106F1P AAA ATPase, central domain protein GR129_RS04315 ENOG4105MVE transcriptional regulator GR129_RS04325 ENOG4105CHR reductase GR129_RS04365 ENOG4105DKQ ROK family GR129_RS04370 ENOG4105CF1 Alkylated DNA repair protein GR129_RS04385 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) GR129_RS04390 ENOG4105D2N Aldolase GR129_RS04400 ENOG4105E98 transcriptional regulator DeoR family GR129_RS04410 ENOG4108KPJ rna polymerase sigma factor GR129_RS04435 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR129_RS04450 ENOG4105C31 Tryptophanyl-tRNA synthetase GR129_RS04475 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GR129_RS04480 ENOG4107PP3 Acetylornithine deacetylase GR129_RS04490 ENOG4105I1F Resistance protein GR129_RS04510 ENOG41060NJ transcriptional regulator GR129_RS04520 ENOG4105C10 Electron transfer flavoprotein GR129_RS04600 ENOG4107SCK Monooxygenase GR129_RS04635 ENOG4105YVS arsR family transcriptional regulator GR129_RS04640 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GR129_RS04655 ENOG4105CSU acyl-Coa dehydrogenase GR129_RS04665 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GR129_RS04695 ENOG4107VXZ Hydrolase GR129_RS04725 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GR129_RS04740 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GR129_RS04750 ENOG4105CAY ferredoxin--nadp reductase GR129_RS04760 ENOG4105BZ1 (ABC) transporter GR129_RS04795 ENOG4105BZ1 (ABC) transporter GR129_RS04820 ENOG4105C29 acyl-CoA thioesterase GR129_RS04830 ENOG4105GWZ Roadblock lc7 family protein GR129_RS04880 ENOG4105E2R ROK family GR129_RS04890 ENOG4107SCA Formamidase (EC 3.5.1.49) GR129_RS04900 ENOG4107RR1 TRANSCRIPTIONal GR129_RS04905 ENOG4105C26 Dehydrogenase GR129_RS04925 ENOG4105EMU Dehydrogenase GR129_RS04960 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GR129_RS05030 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GR129_RS05035 ENOG4105CFG Acts as a chaperone (By similarity) GR129_RS05115 ENOG4106S2D Transcriptional regulator GR129_RS05205 ENOG4105DQR SNARE associated Golgi GR129_RS05240 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS05245 ENOG4105D2B acyl-CoA dehydrogenase GR129_RS05260 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GR129_RS05280 ENOG41065KQ synthase GR129_RS05285 ENOG4106A3M Cytochrome p-450 GR129_RS05295 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS05305 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GR129_RS05315 ENOG4105F1K Glutamine amidotransferase GR129_RS05320 ENOG4105CTQ phosphohexokinase GR129_RS05340 ENOG4105CIK Amidinotransferase GR129_RS05345 ENOG4105C8Y Acetylornithine aminotransferase GR129_RS05355 ENOG4105F6E Acyl-transferase GR129_RS05365 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GR129_RS05375 ENOG4105CQM Urea amidohydrolase subunit alpha GR129_RS05380 ENOG4105KI2 Urea amidohydrolase subunit beta GR129_RS05385 ENOG4108YZ9 Urea amidohydrolase subunit gamma GR129_RS05430 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GR129_RS05440 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GR129_RS05460 ENOG4105FBW Monooxygenase GR129_RS05500 ENOG4105C83 adenylosuccinate lyase GR129_RS05505 ENOG4108VCA G U mismatch-specific DNA glycosylase GR129_RS05515 ENOG4105DKQ ROK family GR129_RS05525 ENOG4105FDP GntR family transcriptional regulator GR129_RS05530 ENOG4108KPJ rna polymerase sigma factor GR129_RS05540 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GR129_RS05590 ENOG4105EYH Exonuclease GR129_RS05600 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GR129_RS05615 ENOG4105K4P CoA-binding domain protein GR129_RS05620 ENOG4107QTZ amino acid GR129_RS05625 ENOG41082SX arsR family transcriptional regulator GR129_RS05650 ENOG4108UW5 maltose o-acetyltransferase GR129_RS05655 ENOG4108Z0R Transferase GR129_RS05680 ENOG4108J2P Alpha beta hydrolase fold GR129_RS05715 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GR129_RS05735 ENOG4107YPT transcriptional regulator GR129_RS05755 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GR129_RS05760 ENOG4105CK5 oxidoreductase GR129_RS05790 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GR129_RS05795 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GR129_RS05800 ENOG4105CHR reductase GR129_RS05835 ENOG4108Q5Y Membrane GR129_RS05840 ENOG4105CSW GntR family transcriptional regulator GR129_RS05880 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GR129_RS05885 ENOG4105JAB phenazine biosynthesis protein, phzf family GR129_RS05955 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GR129_RS05965 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GR129_RS05985 ENOG4108UW8 fha domain-containing protein GR129_RS06035 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GR129_RS06045 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR129_RS06090 ENOG4105GWZ Roadblock lc7 family protein GR129_RS06105 ENOG41069M3 Transcriptional regulator GR129_RS06130 ENOG4107RGD Major Facilitator superfamily GR129_RS06135 ENOG4105CFM UPF0317 protein GR129_RS06140 ENOG4105E7W lamb ycsf family protein GR129_RS06145 ENOG4105P4J Allophanate hydrolase, subunit 1 GR129_RS06155 ENOG4107SCK Monooxygenase GR129_RS06170 ENOG4108MJN Glycosyl Transferase GR129_RS06185 ENOG4105JXB ankyrin repeat-containing protein GR129_RS06205 ENOG4108VW9 Membrane GR129_RS06215 ENOG4105DEU major facilitator superfamily GR129_RS06220 ENOG4105Q70 GR129_RS06230 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GR129_RS06240 ENOG4105EW9 transcriptional regulator AsnC family GR129_RS06255 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS06310 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GR129_RS06315 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GR129_RS06320 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GR129_RS06325 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GR129_RS06340 ENOG4105E2R ROK family GR129_RS06355 ENOG4105C2W permease GR129_RS06365 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GR129_RS06400 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GR129_RS06405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GR129_RS06425 ENOG4108TZY GntR Family Transcriptional Regulator GR129_RS06435 ENOG4105CUB amino acid GR129_RS06465 ENOG4105DKT Transcriptional regulator GR129_RS06470 ENOG4105DJV ribulose-phosphate 3-epimerase GR129_RS06535 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GR129_RS06555 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GR129_RS06570 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GR129_RS06580 ENOG4105SKN orotidine 5''-phosphate decarboxylase GR129_RS06585 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GR129_RS06590 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GR129_RS06595 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GR129_RS06605 ENOG4105CD3 dihydroorotase GR129_RS06615 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GR129_RS06625 ENOG410803B Involved in the transcription termination process (By similarity) GR129_RS06630 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GR129_RS06635 ENOG4105DC7 peptidase M24 GR129_RS06645 ENOG4105D49 3-dehydroquinate synthase GR129_RS06650 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GR129_RS06655 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GR129_RS06665 ENOG4105HHA aminodeoxychorismate lyase GR129_RS06670 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GR129_RS06675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GR129_RS06695 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GR129_RS06710 ENOG4105CUT histidyl-tRNA synthetase GR129_RS06720 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GR129_RS06725 ENOG4105C99 atpase involved in dna repair GR129_RS06730 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GR129_RS06740 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GR129_RS06745 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GR129_RS06750 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GR129_RS06765 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GR129_RS06770 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GR129_RS06775 ENOG4105CDY transcriptional regulatory protein GR129_RS06780 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GR129_RS06785 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GR129_RS06795 ENOG4105E2K Glycosyl transferase (Group 1 GR129_RS06800 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GR129_RS06805 ENOG4108VTU Cdp-alcohol phosphatidyltransferase GR129_RS06825 ENOG4105C22 threonyL-tRNA synthetase GR129_RS06840 ENOG4108IRC dna polymerase iii GR129_RS06865 ENOG4105KF0 sporulation and cell division protein, SsgA GR129_RS06890 ENOG4105F0I Aminotransferase GR129_RS06895 ENOG4105CRQ synthase (Component I) GR129_RS06945 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GR129_RS06965 ENOG4105D01 (LipO)protein GR129_RS06970 ENOG4108UMI ABC transporter, permease GR129_RS06975 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GR129_RS06980 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GR129_RS07010 ENOG4107R16 Multicopper oxidase GR129_RS07015 ENOG4105C57 major facilitator superfamily GR129_RS07020 ENOG4105RJZ Transcriptional regulator GR129_RS07030 ENOG4105CH7 arginosuccinase GR129_RS07035 ENOG4105CDH Citrulline--aspartate ligase GR129_RS07060 ENOG4105BZ1 (ABC) transporter GR129_RS07075 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GR129_RS07080 ENOG4105C8Y Acetylornithine aminotransferase GR129_RS07085 ENOG4105CAS nag kinase GR129_RS07090 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GR129_RS07095 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GR129_RS07120 ENOG4105CKK Glycosyl transferase, family 2 GR129_RS07150 ENOG4105F32 YngK protein GR129_RS07180 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GR129_RS07185 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GR129_RS07190 ENOG4105BZU Histidine kinase GR129_RS07195 ENOG4108RWN rrna methyltransferase GR129_RS07200 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GR129_RS07205 ENOG41084BS 50S ribosomal protein L35 GR129_RS07210 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GR129_RS07250 ENOG4105C26 Dehydrogenase GR129_RS07265 ENOG4108Z86 Glutamine amidotransferase GR129_RS07280 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GR129_RS07290 ENOG4108HQS Glycine betaine GR129_RS07295 ENOG4108IJ7 Glycine betaine GR129_RS07300 ENOG4105HFS 5'-3' exonuclease GR129_RS07320 ENOG4105C34 Pseudouridine synthase GR129_RS07355 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GR129_RS07360 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GR129_RS07380 ENOG4108FFZ Transcriptional regulator GR129_RS07390 ENOG41081K0 peptidylprolyl cis-trans isomerase GR129_RS07395 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GR129_RS07405 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS07410 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GR129_RS07425 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GR129_RS07430 ENOG4105E5F proteasome GR129_RS07435 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GR129_RS07470 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS07475 ENOG4105DEF Extracellular solute-binding protein, family 5 GR129_RS07480 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GR129_RS07485 ENOG4105C3R Methionine synthase GR129_RS07490 ENOG4108K8U Glycerol operon regulatory protein GR129_RS07495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GR129_RS07500 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GR129_RS07505 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GR129_RS07515 ENOG4105C8N cysteinyl-tRNA synthetase GR129_RS07535 ENOG4105D7N magnesium and cobalt transport protein CorA GR129_RS07540 ENOG4105DYW oxidoreductase GR129_RS07545 ENOG4105CPC Aldo Keto reductase GR129_RS07565 ENOG4105S2J secreted protein GR129_RS07645 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR129_RS07650 ENOG4105DCG PHP domain protein GR129_RS07665 ENOG4105K5B UPF0225 protein GR129_RS07670 ENOG4105C6F GntR Family Transcriptional Regulator GR129_RS07675 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GR129_RS07680 ENOG4105C6Z Gluconate GR129_RS07705 ENOG4105PTV Nudix Hydrolase GR129_RS07715 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS07720 ENOG4108IG5 Transcriptional regulator GR129_RS07735 ENOG4105EHZ conserved protein UCP016719 GR129_RS07760 ENOG4105CKT filamentous hemagglutinin GR129_RS07765 ENOG4108Z4X TRANSCRIPTIONal GR129_RS07785 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS07815 ENOG4108SGK Tetr family transcriptional regulator GR129_RS07825 ENOG4105F1J Homogentisate 1,2-dioxygenase GR129_RS07830 ENOG4105FDP GntR family transcriptional regulator GR129_RS07850 ENOG4108TCJ secreted hydrolase GR129_RS07870 ENOG4107BJW polysaccharide deacetylase GR129_RS07895 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GR129_RS07930 ENOG4108Z2K Cupin 2, conserved barrel domain protein GR129_RS07940 ENOG4105C0B DNA polymerase III (alpha subunit) GR129_RS07950 ENOG4106NMR serine protease GR129_RS07965 ENOG4105CDA abc transporter atp-binding protein GR129_RS07975 ENOG4105EAD ABC transporter GR129_RS07980 ENOG4107UBR Extracellular solute-binding protein family 3 GR129_RS07990 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GR129_RS07995 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS08000 ENOG4105C57 major facilitator superfamily GR129_RS08010 ENOG410841Q phosphoesterase PA-phosphatase related protein GR129_RS08025 ENOG4105MS9 Resuscitation-promoting factor GR129_RS08040 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GR129_RS08050 ENOG4105CAT Cytidine monophosphate kinase GR129_RS08075 ENOG410756H nucleotidyltransferase GR129_RS08085 ENOG4105FE9 pseudouridine synthase GR129_RS08090 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GR129_RS08095 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GR129_RS08110 ENOG4105DCF alanine dehydrogenase GR129_RS08125 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GR129_RS08130 ENOG4105BZP glycoside hydrolase 15-related GR129_RS08145 ENOG4107STW synthase GR129_RS08155 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GR129_RS08160 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GR129_RS08180 ENOG4105E0A ABC, transporter GR129_RS08185 ENOG4105TVJ transport system, permease GR129_RS08190 ENOG4105DQ5 transport system permease protein GR129_RS08195 ENOG4105DSU hydrolase GR129_RS08230 ENOG4108VX5 3-methyladenine DNA glycosylase GR129_RS08240 ENOG4108V1U phospholipid-binding protein GR129_RS08260 ENOG4105DKW ABC transporter GR129_RS08275 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS08285 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GR129_RS08290 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GR129_RS08300 ENOG4105IDI abc transporter atp-binding protein GR129_RS08305 ENOG4105EAC phosphoserine phosphatase GR129_RS08310 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GR129_RS08325 ENOG4107YCY Transcriptional regulator GR129_RS08355 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GR129_RS08365 ENOG4105EU0 Major facilitator Superfamily GR129_RS08370 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GR129_RS08380 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GR129_RS08400 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GR129_RS08405 ENOG4107QN1 sodium solute GR129_RS08420 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F GR129_RS08430 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GR129_RS08475 ENOG4105VBF alkaline shock protein GR129_RS08485 ENOG41060WC Enoyl-CoA hydratase GR129_RS08515 ENOG4107W7X Aldolase GR129_RS08535 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GR129_RS08540 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GR129_RS08545 ENOG4105CTK cobaltochelatase, cobn subunit GR129_RS08555 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GR129_RS08560 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GR129_RS08575 ENOG4105CIA precorrin-4 C(11)-methyltransferase GR129_RS08585 ENOG4105E4R Precorrin-3B C17-methyltransferase GR129_RS08590 ENOG41081F0 Precorrin-8x methylmutase GR129_RS08620 ENOG4105E5Q amino acid AbC transporter GR129_RS08625 ENOG4106PMH Extracellular solute-binding protein family 3 GR129_RS08630 ENOG4105C5R Aminotransferase GR129_RS08640 ENOG4108JPW Aminotransferase GR129_RS08645 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GR129_RS08650 ENOG4105EV8 ectoine hydroxylase GR129_RS08670 ENOG41069M3 Transcriptional regulator GR129_RS08695 ENOG4105E98 transcriptional regulator DeoR family GR129_RS08755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GR129_RS08765 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GR129_RS08770 ENOG4108RFG Tetr family transcriptional regulator GR129_RS08785 ENOG4108UNV SUF system FeS assembly protein, NifU family GR129_RS08790 ENOG4105C9B Cysteine desulfurase GR129_RS08795 ENOG4105C3K feS assembly ATPase SufC GR129_RS08825 ENOG4105CJ1 ABC, transporter GR129_RS08835 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GR129_RS08845 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GR129_RS08855 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GR129_RS08870 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GR129_RS08880 ENOG4107QP8 phosphohexose isomerase GR129_RS08900 ENOG4105CP7 Triose-phosphate isomerase GR129_RS08905 ENOG4105BZA Phosphoglycerate kinase GR129_RS08910 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GR129_RS08915 ENOG4105CIE May be required for sporulation (By similarity) GR129_RS08920 ENOG4105CHW UPF0052 protein GR129_RS08925 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GR129_RS08930 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GR129_RS08945 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS08965 ENOG4107VMB Beta-lactamase domain protein GR129_RS08970 ENOG4107R0W ABC transporter GR129_RS08975 ENOG4105E5Q amino acid AbC transporter GR129_RS08985 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GR129_RS08990 ENOG4105CSH Transporter GR129_RS09015 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GR129_RS09020 ENOG4105BZU Histidine kinase GR129_RS09025 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GR129_RS09030 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GR129_RS09035 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GR129_RS09045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR129_RS09050 ENOG4105D7N magnesium and cobalt transport protein CorA GR129_RS09135 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GR129_RS09150 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GR129_RS09155 ENOG4108YRB methyltransferase GR129_RS09160 ENOG4105CQ7 ATP-dependent helicase GR129_RS09195 ENOG4105KA0 thioesterase Superfamily protein GR129_RS09200 ENOG4105CP9 extracellular ligand-binding receptor GR129_RS09205 ENOG4105C32 Amino acid ABC transporter (Permease) GR129_RS09210 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GR129_RS09215 ENOG4105C0Z ABC transporter GR129_RS09220 ENOG4108IV0 ABC, transporter GR129_RS09265 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GR129_RS09270 ENOG41063TF transcriptional regulator (AraC GR129_RS09285 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GR129_RS09290 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GR129_RS09295 ENOG4105E39 Enoyl-CoA hydratase GR129_RS09310 ENOG4105EA8 2-Nitropropane dioxygenase GR129_RS09315 ENOG4105CHU acetyl-coa acetyltransferase GR129_RS09325 ENOG4105CHR reductase GR129_RS09330 ENOG4105CC9 acyl-Coa dehydrogenase GR129_RS09335 ENOG4105D2B acyl-CoA dehydrogenase GR129_RS09355 ENOG4105CBC glutamate synthase GR129_RS09365 ENOG41065RQ ADP-ribosylation crystallin J1 GR129_RS09385 ENOG4108RVA ribokinase GR129_RS09390 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GR129_RS09400 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GR129_RS09410 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GR129_RS09415 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GR129_RS09425 ENOG4105DK0 Indole-3-glycerol phosphate synthase GR129_RS09450 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GR129_RS09460 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GR129_RS09475 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GR129_RS09480 ENOG4108176 endoribonuclease L-psp GR129_RS09485 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GR129_RS09490 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GR129_RS09495 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GR129_RS09500 ENOG4105CIH Imidazole acetol-phosphate transaminase GR129_RS09505 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GR129_RS09525 ENOG4108Z66 YbaK ebsC protein GR129_RS09550 ENOG4105C0B DNA polymerase III (alpha subunit) GR129_RS09595 ENOG41082BV acetyltransferase GR129_RS09605 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GR129_RS09610 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GR129_RS09615 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GR129_RS09630 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GR129_RS09635 ENOG4105DFA alanine racemase domain protein GR129_RS09640 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GR129_RS09645 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GR129_RS09650 ENOG4105ME9 cell division protein FtsQ GR129_RS09655 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GR129_RS09665 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GR129_RS09670 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GR129_RS09680 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GR129_RS09685 ENOG4105CJN penicillin-binding protein GR129_RS09695 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GR129_RS09705 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GR129_RS09735 ENOG4105BZ1 (ABC) transporter GR129_RS09740 ENOG4105ECB domain protein GR129_RS09745 ENOG4107Z3H Transcriptional regulator, TetR family GR129_RS09770 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GR129_RS09800 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GR129_RS09810 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GR129_RS09820 ENOG4108UQY Iron-storage protein GR129_RS09845 ENOG4105CTQ phosphohexokinase GR129_RS09850 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS09855 ENOG4105ENE Histidine kinase GR129_RS09880 ENOG4105DKQ ROK family GR129_RS09890 ENOG4105D0U Arsenite-activated ATPase (ArsA) GR129_RS09910 ENOG4105JNK Glycosyl transferase (Group 1 GR129_RS09925 ENOG4105ZXU NLP P60 protein GR129_RS09955 ENOG4105C9B Cysteine desulfurase GR129_RS09960 ENOG4108I0Q anthranilate phosphoribosyltransferase GR129_RS09965 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GR129_RS09970 ENOG4107EUI c reductase, iron-sulfur GR129_RS09975 ENOG4107UDY cytochrome C GR129_RS09980 ENOG4105CCU oxidase (Subunit III) GR129_RS09995 ENOG4105MCD Part of cytochrome c oxidase, its function is GR129_RS10000 ENOG4105BZ9 Cytochrome C oxidase, subunit I GR129_RS10005 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GR129_RS10045 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GR129_RS10050 ENOG4105BZU Histidine kinase GR129_RS10055 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS10090 ENOG4105C0H protease GR129_RS10100 ENOG4108YZT Adenosylcobinamide kinase GR129_RS10110 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GR129_RS10115 ENOG4105CRK lysyL-tRNA synthetase GR129_RS10130 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GR129_RS10155 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GR129_RS10195 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GR129_RS10200 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GR129_RS10220 ENOG4105C5F glutamine synthetase GR129_RS10240 ENOG4105D0M Protease HtpX homolog GR129_RS10255 ENOG4108222 arsenate reductase GR129_RS10265 ENOG4107R5B glutamine synthetase GR129_RS10270 ENOG4107NHD transcriptional regulator GR129_RS10285 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS10325 ENOG4105CG3 alpha amylase, catalytic region GR129_RS10330 ENOG4105EG2 ABC transporter, permease GR129_RS10335 ENOG4105D56 permease protein GR129_RS10345 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS10355 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GR129_RS10370 ENOG4105C5F glutamine synthetase GR129_RS10380 ENOG41081JD Transcriptional regulator GR129_RS10465 ENOG4105F27 Major Facilitator GR129_RS10480 ENOG4105C57 major facilitator superfamily GR129_RS10485 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GR129_RS10515 ENOG4107XZ0 Peptidase M50 GR129_RS10570 ENOG4105EHG Permease protein GR129_RS10575 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GR129_RS10580 ENOG410650H (LipO)protein GR129_RS10585 ENOG4105DBE peroxidase GR129_RS10595 ENOG4106A0S GR129_RS10610 ENOG4107S1E Beta-lactamase GR129_RS10615 ENOG4105C2C drug resistance transporter, Bcr CflA GR129_RS10635 ENOG4108VGI doxx family GR129_RS10725 ENOG4107XFJ UPF0246 protein GR129_RS10730 ENOG4108UHU Aldolase GR129_RS10735 ENOG4105CVJ phosphoglycerate mutase GR129_RS10745 ENOG4105EGD dinuclear metal center protein, YbgI family GR129_RS10755 ENOG4105CHR reductase GR129_RS10770 ENOG4108M15 ABC transporter GR129_RS10780 ENOG4105BZU Histidine kinase GR129_RS10825 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GR129_RS10835 ENOG4105DYW oxidoreductase GR129_RS10850 ENOG4107QVI Methyltransferase, type 11 GR129_RS10860 ENOG4108SGK Tetr family transcriptional regulator GR129_RS10915 ENOG4108JJB ABC transporter GR129_RS10925 ENOG4106770 Is able to cleave peptidoglycan (By similarity) GR129_RS10930 ENOG4105XPP Protein of unknown function (DUF1275) GR129_RS10935 ENOG4106A3M Cytochrome p-450 GR129_RS10940 ENOG4105F2C Acetyl-CoA acetyltransferase GR129_RS10950 ENOG4105CSH Transporter GR129_RS10975 ENOG4105DZ2 Transcriptional regulator GR129_RS11015 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GR129_RS11045 ENOG4105EEM helicase GR129_RS11085 ENOG4105BZ4 penicillin-binding protein GR129_RS11100 ENOG4105DAX Pfam:DUF2983 GR129_RS11145 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GR129_RS11170 ENOG4105CPC Aldo Keto reductase GR129_RS11175 ENOG4105VUF Transcriptional regulator GR129_RS11205 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR129_RS11210 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GR129_RS11235 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GR129_RS11245 ENOG4105CHJ isochorismatase hydrolase GR129_RS11250 ENOG4105CHJ isochorismatase hydrolase GR129_RS11260 ENOG4105EXN Sulfate transport protein CysZ GR129_RS11270 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GR129_RS11325 ENOG4105C57 major facilitator superfamily GR129_RS11370 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS11375 ENOG4105D8K carboxyl transferase GR129_RS11405 ENOG4105DFF Rod shape-determining protein mreb GR129_RS11480 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS11485 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GR129_RS11495 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GR129_RS11500 ENOG4108UB4 uncharacterized protein ygjQ GR129_RS11525 ENOG4105DRS transport system, permease GR129_RS11570 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GR129_RS11575 ENOG4105E2R ROK family GR129_RS11630 ENOG4108FN7 Aldo keto reductase GR129_RS11640 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GR129_RS11650 ENOG4105FDK ABC transporter GR129_RS11665 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GR129_RS11670 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GR129_RS11680 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR129_RS11685 ENOG4106F59 XRE family Transcriptional regulator GR129_RS11690 ENOG4105DEF Extracellular solute-binding protein, family 5 GR129_RS11700 ENOG4105C3U ABC transporter GR129_RS11705 ENOG4108JQ7 (ABC) transporter GR129_RS11710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GR129_RS11715 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GR129_RS11720 ENOG41064MX Tetr family transcriptional regulator GR129_RS11725 ENOG4108478 ec 3.2.1.18 GR129_RS11735 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GR129_RS11760 ENOG4105CS2 ec 3.2.1.21 GR129_RS11770 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GR129_RS11805 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GR129_RS11810 ENOG4105MSB protein, conserved in bacteria GR129_RS11820 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GR129_RS11840 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GR129_RS11845 ENOG4107YU2 histidine triad (hIT) protein GR129_RS11875 ENOG4107QWG 2-Nitropropane dioxygenase GR129_RS11880 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GR129_RS11885 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GR129_RS11920 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GR129_RS11930 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GR129_RS11945 ENOG4108YYC ycei family GR129_RS11960 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GR129_RS11965 ENOG4105EPR degv family GR129_RS11975 ENOG4105C8T Leucyl-tRNA synthetase GR129_RS11995 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GR129_RS12000 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GR129_RS12010 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GR129_RS12015 ENOG4105D0M Protease HtpX homolog GR129_RS12030 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GR129_RS12040 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GR129_RS12045 ENOG4107SJB teichoic acid biosynthesis GR129_RS12050 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GR129_RS12060 ENOG4105K46 50S ribosomal protein l27 GR129_RS12065 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GR129_RS12070 ENOG4108MDK Dehydrogenase GR129_RS12080 ENOG4105C03 ribonuclease GR129_RS12100 ENOG410650H (LipO)protein GR129_RS12105 ENOG4105DBE peroxidase GR129_RS12120 ENOG4105CNI cell division protein FtsW GR129_RS12125 ENOG4105CJN penicillin-binding protein GR129_RS12140 ENOG4105DFF Rod shape-determining protein mreb GR129_RS12145 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GR129_RS12155 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GR129_RS12160 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GR129_RS12170 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GR129_RS12180 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GR129_RS12185 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GR129_RS12200 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GR129_RS12220 ENOG4108TGC Acyltransferase GR129_RS12240 ENOG4108YZG isomerase GR129_RS12245 ENOG4105C85 amino acid GR129_RS12255 ENOG4105E2R ROK family GR129_RS12265 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GR129_RS12270 ENOG4105E2Y ABC, transporter GR129_RS12285 ENOG4105C85 amino acid GR129_RS12295 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GR129_RS12305 ENOG4105MC2 DSBA oxidoreductase GR129_RS12365 ENOG4107SCK Monooxygenase GR129_RS12395 ENOG4105D8X mechanosensitive ion channel GR129_RS12415 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GR129_RS12420 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GR129_RS12425 ENOG4105F8D glycoside hydrolase family 4 GR129_RS12440 ENOG4105CT1 (ABC) transporter GR129_RS12470 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR129_RS12520 ENOG4105VHU single-stranded DNA-binding protein GR129_RS12565 ENOG4105CMR udp-glucose 4-epimerase GR129_RS12590 ENOG4108IUW ABC transporter GR129_RS12615 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS12630 ENOG4108UW5 maltose o-acetyltransferase GR129_RS12650 ENOG4105DFA alanine racemase domain protein GR129_RS12665 ENOG4108JQ1 Dehydrogenase GR129_RS12710 ENOG4105S2J secreted protein GR129_RS12740 ENOG4105CJ1 ABC, transporter GR129_RS12750 ENOG4105C26 Dehydrogenase GR129_RS12760 ENOG4105DH8 myo-inositol catabolism GR129_RS12770 ENOG4105EDK PfkB domain protein GR129_RS12805 ENOG4105C7H Helicase, RecD TraA family GR129_RS12820 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS12825 ENOG4105C2J ABC transporter GR129_RS12830 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GR129_RS12835 ENOG4108RVA ribokinase GR129_RS12840 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GR129_RS12860 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GR129_RS12880 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS12885 ENOG4105HSS phospholipase C GR129_RS12930 ENOG4105C7K acetolactate synthase GR129_RS12945 ENOG4108XFF GR129_RS12955 ENOG4105C29 acyl-CoA thioesterase GR129_RS12975 ENOG4107QX3 carboxylase GR129_RS12985 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GR129_RS12990 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS13010 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GR129_RS13020 ENOG4105DUU IucA IucC family protein GR129_RS13035 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GR129_RS13045 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GR129_RS13050 ENOG4105ECQ AraC Family Transcriptional Regulator GR129_RS13085 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS13110 ENOG4108NNZ chitinase GR129_RS13115 ENOG410804D Sensor Signal Transduction Histidine Kinase GR129_RS13145 ENOG4108ZM9 phosphoglycerate mutase GR129_RS13190 ENOG4105BZU Histidine kinase GR129_RS13195 ENOG4105DEN Luciferase family GR129_RS13205 ENOG4105C5I Dehydrogenase GR129_RS13220 ENOG4108M1A Chitin-binding protein GR129_RS13240 ENOG4105JXH GntR family transcriptional regulator GR129_RS13265 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component GR129_RS13275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GR129_RS13280 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GR129_RS13290 ENOG41080U6 GntR family transcriptional regulator GR129_RS13315 ENOG4105D9R oxidoreductase GR129_RS13320 ENOG41090KN UPF0303 protein GR129_RS13340 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GR129_RS13350 ENOG4107YPT transcriptional regulator GR129_RS13360 ENOG4108U4N (sortase) family GR129_RS13380 ENOG4108F3G Type I restriction-modification system, R subunit GR129_RS13400 ENOG41087EV Hsp20/alpha crystallin family GR129_RS13410 ENOG4107QNK )-transporter GR129_RS13415 ENOG4106BRA Membrane GR129_RS13425 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GR129_RS13460 ENOG4105KPY Small multidrug resistance protein GR129_RS13465 ENOG4105BZ4 penicillin-binding protein GR129_RS13480 ENOG4105CJ1 ABC, transporter GR129_RS13495 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GR129_RS13500 ENOG4105CI1 PTS System GR129_RS13550 ENOG4105C85 amino acid GR129_RS13565 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GR129_RS13575 ENOG4108RWI nicotinamidase GR129_RS13585 ENOG4107G87 m6 family metalloprotease domain protein GR129_RS13605 ENOG4105KF0 sporulation and cell division protein, SsgA GR129_RS13610 ENOG4105CQB FAD linked oxidase domain protein GR129_RS13620 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GR129_RS13685 ENOG4105E2D ec 3.2.1.52 GR129_RS13695 ENOG4108UJU UPF0301 protein GR129_RS13700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GR129_RS13705 ENOG4108426 dNA-binding protein GR129_RS13715 ENOG4105EEM helicase GR129_RS13725 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GR129_RS13735 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GR129_RS13740 ENOG4105CN1 protease GR129_RS13745 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) GR129_RS13750 ENOG4105CAK Cell division ATP-binding protein ftsE GR129_RS13765 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GR129_RS13770 ENOG4108QVN serine threonine protein kinase GR129_RS13775 ENOG4108UGD Serine Threonine protein kinase GR129_RS13785 ENOG4108JP0 extracellular solute-binding protein family 1 GR129_RS13795 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GR129_RS13825 ENOG4107SJB teichoic acid biosynthesis GR129_RS13830 ENOG4107SJB teichoic acid biosynthesis GR129_RS13835 ENOG4108ZHJ Organic hydroperoxide resistance protein GR129_RS13840 ENOG4105K56 Transcriptional regulator GR129_RS13860 ENOG4105CMR udp-glucose 4-epimerase GR129_RS13880 ENOG4105EY8 ABC transporter GR129_RS13885 ENOG4107SJB teichoic acid biosynthesis GR129_RS13890 ENOG4105K64 Glycosyl transferase, family 2 GR129_RS13900 ENOG4105C7I Dehydrogenase GR129_RS13925 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GR129_RS13935 ENOG4105T0Z Conserved Protein GR129_RS13940 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS13945 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GR129_RS13955 ENOG4105G3P Lipoprotein lpqB GR129_RS13960 ENOG4105BZU Histidine kinase GR129_RS13965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR129_RS13970 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GR129_RS13985 ENOG4108WQ6 secreted protein GR129_RS13990 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GR129_RS14030 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GR129_RS14040 ENOG4105EIP mannose-6-phosphate isomerase GR129_RS14050 ENOG4105W49 UPF0434 protein GR129_RS14085 ENOG4107RGC Glycosyl transferase, family 2 GR129_RS14090 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR129_RS14100 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase GR129_RS14105 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) GR129_RS14115 ENOG4107V9E glucose-1-phosphate thymidylyltransferase GR129_RS14125 ENOG4108KGH TRANSCRIPTIONal GR129_RS14130 ENOG4108KGH TRANSCRIPTIONal GR129_RS14135 ENOG4108KGH TRANSCRIPTIONal GR129_RS14145 ENOG4108KGH TRANSCRIPTIONal GR129_RS14155 ENOG4108KGH TRANSCRIPTIONal GR129_RS14170 ENOG4105C6Y Udp-glucose 6-dehydrogenase GR129_RS14195 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GR129_RS14210 ENOG41065SU Two-component system sensor kinase GR129_RS14215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR129_RS14220 ENOG4105DUX Transporter GR129_RS14250 ENOG41082AN stage II sporulation protein GR129_RS14255 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS14260 ENOG4105CI2 imidazolone-5-propionate hydrolase GR129_RS14275 ENOG4105CGP Urocanate hydratase GR129_RS14335 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS14340 ENOG4105D82 Glutamate dehydrogenase GR129_RS14345 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GR129_RS14350 ENOG4105CAS nag kinase GR129_RS14355 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GR129_RS14360 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GR129_RS14375 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS14380 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS14385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR129_RS14390 ENOG41064MX Tetr family transcriptional regulator GR129_RS14415 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GR129_RS14420 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR129_RS14475 ENOG4105CHU acetyl-coa acetyltransferase GR129_RS14505 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR129_RS14510 ENOG4107RBB ABC transporter, permease GR129_RS14515 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GR129_RS14520 ENOG4105CEP NADH dehydrogenase GR129_RS14550 ENOG4105MS9 Resuscitation-promoting factor GR129_RS14560 ENOG4106A3M Cytochrome p-450 GR129_RS14615 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR129_RS14620 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR129_RS14670 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GR129_RS14675 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GR129_RS14680 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GR129_RS14685 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GR129_RS14695 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GR129_RS14705 ENOG41067SE Tetr family transcriptional regulator GR129_RS14725 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GR129_RS14730 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GR129_RS14735 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS14745 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GR129_RS14785 ENOG4105C5H ABC transporter GR129_RS14795 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GR129_RS14800 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GR129_RS14810 ENOG4105F8V Hydrolase, tatD family GR129_RS14865 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GR129_RS14875 ENOG4108JJB ABC transporter GR129_RS14890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GR129_RS14925 ENOG4105EYF MMPL domain protein GR129_RS14945 ENOG4108R85 Short chain dehydrogenase GR129_RS14955 ENOG4105F95 Monooxygenase GR129_RS14965 ENOG4105CGK Exodeoxyribonuclease III GR129_RS14985 ENOG4108Z9I -acetyltransferase GR129_RS14990 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GR129_RS14995 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GR129_RS15010 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GR129_RS15025 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR129_RS15035 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GR129_RS15060 ENOG4105KXX peptidase s58 dmpa GR129_RS15065 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GR129_RS15105 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GR129_RS15130 ENOG4105DMF Dehydrogenase GR129_RS15140 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR129_RS15150 ENOG4107WFU Glutamate mutase subunit sigma GR129_RS15230 ENOG4108V06 Glutathione peroxidase GR129_RS15300 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GR129_RS15315 ENOG4105C26 Dehydrogenase GR129_RS15330 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GR129_RS15355 ENOG4106F59 XRE family Transcriptional regulator GR129_RS15360 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS15380 ENOG4108762 serine threonine protein kinase GR129_RS15395 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GR129_RS15400 ENOG4105F7P transcriptional regulator AsnC family GR129_RS15405 ENOG4105N14 lysine exporter protein LysE YggA GR129_RS15415 ENOG4105D2B acyl-CoA dehydrogenase GR129_RS15440 ENOG4105H3G oxidoreductase GR129_RS15445 ENOG4105CPF Cell wall formation (By similarity) GR129_RS15450 ENOG4105CGU Enoyl-CoA hydratase GR129_RS15465 ENOG4105D2S major facilitator superfamily GR129_RS15480 ENOG4105CC9 acyl-Coa dehydrogenase GR129_RS15500 ENOG4105D2B acyl-CoA dehydrogenase GR129_RS15505 ENOG4105CC9 acyl-Coa dehydrogenase GR129_RS15555 ENOG4105WN5 stage II sporulation protein GR129_RS15605 ENOG4108SU4 UPF0309 protein GR129_RS15615 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GR129_RS15635 ENOG41060WC Enoyl-CoA hydratase GR129_RS15640 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS15655 ENOG4107QX3 carboxylase GR129_RS15680 ENOG4107AQZ Membrane GR129_RS15690 ENOG4105CQB FAD linked oxidase domain protein GR129_RS15695 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GR129_RS15735 ENOG4105CPC Aldo Keto reductase GR129_RS15775 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GR129_RS15800 ENOG4108N0W Major Facilitator superfamily GR129_RS15810 ENOG4108UIH futalosine nucleosidase GR129_RS15815 ENOG4105E63 Pfam:DUF178 GR129_RS15820 ENOG4105VEQ Cold shock protein GR129_RS15855 ENOG4105CFI type iii restriction protein res subunit GR129_RS15870 ENOG4105EEM helicase GR129_RS15880 ENOG4105DZ6 Band 7 protein GR129_RS15895 ENOG4106N3A copper homeostasis protein cutc GR129_RS15920 ENOG4105QEK Transcriptional regulator GR129_RS15925 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GR129_RS15930 ENOG4105C5Y PTS System GR129_RS15935 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GR129_RS15950 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GR129_RS15955 ENOG4105VEQ Cold shock protein GR129_RS15965 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GR129_RS15970 ENOG4105C3Q Glycosyl transferase, family 2 GR129_RS15990 ENOG4105XN3 extracellular solute-binding protein family 1 GR129_RS16000 ENOG4105CE4 GlcNAc 6-P deacetylase GR129_RS16005 ENOG4105DE4 1-phosphofructokinase GR129_RS16015 ENOG4105BZU Histidine kinase GR129_RS16030 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GR129_RS16085 ENOG4105KTE polyketide synthesis cyclase GR129_RS16090 ENOG4108Y5I Cyclase dehydrase GR129_RS16095 ENOG41079R3 acyl carrier protein GR129_RS16100 ENOG4108PDG Beta-ketoacyl synthase GR129_RS16115 ENOG4105PEJ SchA CurD domain protein GR129_RS16130 ENOG4108IJ9 (ABC) transporter GR129_RS16140 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GR129_RS16150 ENOG4105C2N RNA methyltransferase TrmH family group 3 GR129_RS16155 ENOG4105C8N cysteinyl-tRNA synthetase GR129_RS16160 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR129_RS16185 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GR129_RS16190 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GR129_RS16195 ENOG4108VJ1 Transcriptional regulator (CarD family GR129_RS16215 ENOG4105BZU Histidine kinase GR129_RS16230 ENOG41082YX Transcriptional regulator, arsr family GR129_RS16250 ENOG4105FDP GntR family transcriptional regulator GR129_RS16285 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GR129_RS16310 ENOG4108YZJ Pfam:DUF2596 GR129_RS16315 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GR129_RS16325 ENOG4105ZXU NLP P60 protein GR129_RS16330 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GR129_RS16370 ENOG4105DB7 PHP domain protein GR129_RS16400 ENOG4105JSC dimethylmenaquinone methyltransferase GR129_RS16410 ENOG4105YIP Tetr family transcriptional regulator GR129_RS16420 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GR129_RS16425 ENOG4107YCY Transcriptional regulator GR129_RS16435 ENOG4105CMD Transcriptional regulator, GntR family GR129_RS16440 ENOG4105HHS UPF0256 protein GR129_RS16450 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GR129_RS16455 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GR129_RS16465 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GR129_RS16475 ENOG4105PKJ carbohydrate binding GR129_RS16480 ENOG4105KHC sulfurtransferase GR129_RS16515 ENOG4107NHD transcriptional regulator GR129_RS16520 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS16525 ENOG4105C0H protease GR129_RS16535 ENOG4105ETX regulatoR GR129_RS16545 ENOG4105FQP Beta-lactamase GR129_RS16550 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GR129_RS16555 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GR129_RS16560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GR129_RS16570 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GR129_RS16610 ENOG4105CJ3 phosphate transporter GR129_RS16620 ENOG4105VPX protein, conserved in bacteria GR129_RS16645 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GR129_RS16665 ENOG4105DNP FAD linked oxidase domain protein GR129_RS16670 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GR129_RS16675 ENOG4107SN7 NLP P60 protein GR129_RS16685 ENOG4105CHR reductase GR129_RS16690 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GR129_RS16805 ENOG4105D5U fad dependent oxidoreductase GR129_RS16810 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GR129_RS16835 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GR129_RS16870 ENOG4105C1J atp-dependent rna helicase GR129_RS16915 ENOG4105CQ7 ATP-dependent helicase GR129_RS16930 ENOG4108TAC GR129_RS16945 ENOG4105CXB phosphoribosylaminoimidazole synthetase GR129_RS16965 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GR129_RS16970 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GR129_RS16975 ENOG410839H phosphoribosylformylglycinamidine synthase GR129_RS17020 ENOG4105C8V SAICAR synthetase GR129_RS17035 ENOG4105C12 Phosphoribosylglycinamide synthetase GR129_RS17060 ENOG4107ZQV short-chain dehydrogenase reductase GR129_RS17090 ENOG4105D7A ATP-binding protein GR129_RS17105 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GR129_RS17120 ENOG4108Z6B deaminase GR129_RS17135 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein GR129_RS17140 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS17145 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS17160 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GR129_RS17180 ENOG410905P Pyridoxamine 5-phosphate GR129_RS17195 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GR129_RS17200 ENOG4105BZU Histidine kinase GR129_RS17205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR129_RS17260 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS17265 ENOG4105NAF rna polymerase sigma factor GR129_RS17310 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GR129_RS17335 ENOG4105D9U N-acetyltransferase GR129_RS17370 ENOG4105DBE peroxidase GR129_RS17380 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GR129_RS17385 ENOG4105J7I hydrolase GR129_RS17405 ENOG4105DA5 (ABC) transporter GR129_RS17420 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) GR129_RS17455 ENOG4108K4B hydrolase GR129_RS17460 ENOG4108JJ9 ABC, transporter GR129_RS17465 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GR129_RS17470 ENOG4105C4M (Ubiquinol oxidase) subunit I GR129_RS17475 ENOG4105CIH Imidazole acetol-phosphate transaminase GR129_RS17485 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GR129_RS17495 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GR129_RS17510 ENOG4107HP6 Transcriptional regulator GR129_RS17520 ENOG4106048 Cupin 2, conserved barrel domain protein GR129_RS17525 ENOG41082T9 Membrane GR129_RS17530 ENOG4105KJF protein tyrosine phosphatase GR129_RS17535 ENOG4105C28 cystathionine GR129_RS17560 ENOG4105F27 Major Facilitator GR129_RS17595 ENOG4105CDU Replicative dna helicase GR129_RS17605 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GR129_RS17610 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GR129_RS17615 ENOG4107YH6 single-stranded DNA-binding protein GR129_RS17620 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GR129_RS17645 ENOG4105BZ4 penicillin-binding protein GR129_RS17665 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GR129_RS17680 ENOG4105D9P serine threonine protein kinase GR129_RS17695 ENOG4105C3M thioredoxin reductase GR129_RS17700 ENOG4105K63 Thioredoxin GR129_RS17715 ENOG4107QJE Chromosome Partitioning Protein GR129_RS17720 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GR129_RS17730 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GR129_RS17735 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GR129_RS17740 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GR129_RS17745 ENOG41084CH 50S ribosomal protein l34 GR129_RS17750 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GR129_RS17755 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GR129_RS17760 ENOG4108J5G 6-phosphogluconate dehydrogenase GR129_RS17765 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GR129_RS17770 ENOG4105K7N UPF0232 protein GR129_RS17775 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GR129_RS17800 ENOG4108HMN Caspase domain GR129_RS17835 ENOG4108UGD Serine Threonine protein kinase GR129_RS17850 ENOG4106NZI LysR family Transcriptional regulator GR129_RS17860 ENOG4105C0W non-ribosomal peptide synthetase GR129_RS17875 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS17885 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GR129_RS17890 ENOG4105CHR reductase GR129_RS17895 ENOG4105EV8 ectoine hydroxylase GR129_RS17935 ENOG4105ZJT Cell division protein CrgA GR129_RS17945 ENOG4108U4N (sortase) family GR129_RS17960 ENOG4108U4N (sortase) family GR129_RS17965 ENOG4108RN7 integral membrane protein GR129_RS17975 ENOG4105CJN penicillin-binding protein GR129_RS17990 ENOG4105HZM Fha domain containing protein GR129_RS17995 ENOG4105TV9 FHA Domain-Containing protein GR129_RS18035 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GR129_RS18040 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GR129_RS18045 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GR129_RS18050 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GR129_RS18055 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GR129_RS18070 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GR129_RS18080 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR129_RS18085 ENOG4108IG5 Transcriptional regulator GR129_RS18110 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GR129_RS18115 ENOG4105CVM Molybdenum cofactor synthesis domain protein GR129_RS18120 ENOG4107SVH Potassium channel protein GR129_RS18140 ENOG4107QPV Serine Threonine protein kinase GR129_RS18160 ENOG4105CPP Dehydrogenase, E1 component GR129_RS18165 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GR129_RS18200 ENOG4105DJB Major Facilitator Superfamily GR129_RS18235 ENOG4105DFM M18 family aminopeptidase GR129_RS18240 ENOG4105CSU acyl-Coa dehydrogenase GR129_RS18265 ENOG4105C9M aspartyl-trna synthetase GR129_RS18275 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GR129_RS18285 ENOG4105F2Z 3-oxoadipate enol-lactonase GR129_RS18290 ENOG4107SQD Transcriptional regulator, GntR family GR129_RS18315 ENOG4105CH2 amidohydrolase GR129_RS18335 ENOG4105DU0 nucleoside hydrolase GR129_RS18340 ENOG4105CG3 alpha amylase, catalytic region GR129_RS18355 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GR129_RS18385 ENOG4108M4U conserved membrane protein GR129_RS18410 ENOG4108KPJ rna polymerase sigma factor GR129_RS18420 ENOG4105J7D transcriptional regulator GR129_RS18425 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GR129_RS18480 ENOG4105C1J atp-dependent rna helicase GR129_RS18485 ENOG4105VEQ Cold shock protein GR129_RS18495 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GR129_RS18595 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR129_RS18675 ENOG4105DHP deoxycytidine triphosphate deaminase GR129_RS18680 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GR129_RS18695 ENOG4105DF6 Fe-S oxidoreductase GR129_RS18705 ENOG4105CFG Acts as a chaperone (By similarity) GR129_RS18710 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GR129_RS18715 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GR129_RS18720 ENOG4105KNI merR family transcriptional Regulator GR129_RS18725 ENOG4105DFW ABC transporter GR129_RS18755 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GR129_RS18785 ENOG4108E19 Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GR129_RS18820 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GR129_RS18825 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GR129_RS18835 ENOG4105BZU Histidine kinase GR129_RS18840 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS18865 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GR129_RS18870 ENOG4105CGH 5'-nucleotidase GR129_RS18880 ENOG4108WYP Transcriptional regulator GR129_RS18885 ENOG4108JPW Aminotransferase GR129_RS18900 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GR129_RS18905 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GR129_RS18915 ENOG4105CFH Aspartokinase GR129_RS18925 ENOG4105NAF rna polymerase sigma factor GR129_RS18955 ENOG4105XTG Pfam:DUF156 GR129_RS18970 ENOG4105BZ9 Cytochrome C oxidase, subunit I GR129_RS19035 ENOG4105CVR type I restriction-modification system GR129_RS19050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GR129_RS19160 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS19230 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GR129_RS19265 ENOG4105D74 hydrolase GR129_RS19280 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR129_RS19345 ENOG4108I5C dEAD DEAH box helicase GR129_RS19350 ENOG4105WN5 stage II sporulation protein GR129_RS19355 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GR129_RS19380 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GR129_RS19385 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GR129_RS19420 ENOG4105C2M dna polymerase I GR129_RS19460 ENOG4105C26 Dehydrogenase GR129_RS19470 ENOG4105CVK Glutamate decarboxylase GR129_RS19475 ENOG4107TXC Transcriptional regulator GR129_RS19490 ENOG4105F0N pyrophosphate phospho-hydrolase GR129_RS19505 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GR129_RS19510 ENOG4108UGV hypoxanthine phosphoribosyltransferase GR129_RS19520 ENOG4105EUJ GTP cyclohydrolase i GR129_RS19530 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GR129_RS19550 ENOG4105CRK lysyL-tRNA synthetase GR129_RS19565 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS19580 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS19595 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GR129_RS19600 ENOG4108IYU L-aspartate oxidase GR129_RS19610 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GR129_RS19650 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GR129_RS19660 ENOG4105DR5 peptidase GR129_RS19665 ENOG4108IG5 Transcriptional regulator GR129_RS19675 ENOG4108FKE two-component system sensor kinase GR129_RS19680 ENOG4108PYU two-component system response regulator GR129_RS19685 ENOG41075QH Lipoprotein CseA GR129_RS19690 ENOG4105NAF rna polymerase sigma factor GR129_RS19695 ENOG4105CEN a g-specific adenine glycosylase GR129_RS19705 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GR129_RS19720 ENOG4108JWX GR129_RS19725 ENOG4107R33 ppx gppa phosphatase GR129_RS19730 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GR129_RS19735 ENOG4108IG5 Transcriptional regulator GR129_RS19740 ENOG4105C01 Dihydroxy-acid dehydratase GR129_RS19745 ENOG4108762 serine threonine protein kinase GR129_RS19750 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GR129_RS19770 ENOG4105II7 pyrroline-5-carboxylate reductase GR129_RS19805 ENOG4106UW1 Major Facilitator superfamily GR129_RS19810 ENOG4105DGU Histone deacetylase GR129_RS19850 ENOG4108RXW HAD-superfamily subfamily IB hydrolase GR129_RS19860 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GR129_RS19865 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GR129_RS19870 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GR129_RS19875 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GR129_RS19910 ENOG4105DHP deoxycytidine triphosphate deaminase GR129_RS19930 ENOG4105XEA Tetr family transcriptional regulator GR129_RS19935 ENOG4105CHR reductase GR129_RS19945 ENOG4105D52 delta-aminolevulinic acid dehydratase GR129_RS19950 ENOG4108M8W Monooxygenase GR129_RS19990 ENOG4105C75 arginyL-tRNA synthetase GR129_RS19995 ENOG4105DK7 lysyl-tRNA synthetase GR129_RS20015 ENOG4105E0Y RtcB Protein GR129_RS20035 ENOG4105KK4 UPF0060 membrane protein GR129_RS20045 ENOG4108UZX fmn reductase GR129_RS20055 ENOG41062D9 Histidine kinase GR129_RS20060 ENOG4105CRK lysyL-tRNA synthetase GR129_RS20075 ENOG4105D9P serine threonine protein kinase GR129_RS20090 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS20140 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GR129_RS20145 ENOG4108RH7 phosphoglycerate mutase GR129_RS20160 ENOG4107QIV Cytochrome c biogenesis protein GR129_RS20165 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GR129_RS20170 ENOG4105CRE cytochrome C GR129_RS20205 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GR129_RS20215 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GR129_RS20225 ENOG4105DVY radical SAM domain protein GR129_RS20230 ENOG4108UN4 phage SPO1 DNA polymerase-related protein GR129_RS20245 ENOG4108R86 Transcriptional regulator GR129_RS20250 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GR129_RS20300 ENOG4105MVH Clavaminate synthase GR129_RS20310 ENOG4107QQG Dehydrogenase GR129_RS20320 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GR129_RS20410 ENOG4105VEQ Cold shock protein GR129_RS20415 ENOG4105EV6 Pfam:DUF178 GR129_RS20435 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GR129_RS20445 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR129_RS20455 ENOG4105KNA -acetyltransferase GR129_RS20465 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GR129_RS20480 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20485 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GR129_RS20490 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20500 ENOG4107QIZ NADH dehydrogenase GR129_RS20505 ENOG4108IEH NADH dehydrogenase subunit g GR129_RS20510 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GR129_RS20515 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20520 ENOG41087XN oxidoreductase GR129_RS20525 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20530 ENOG4105D65 subunit l GR129_RS20540 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20555 ENOG4105C9U ATP-dependent DNA helicase RecQ GR129_RS20580 ENOG410667J hydrolase GR129_RS20585 ENOG4108FKH Transglycosylase SLT domain GR129_RS20625 ENOG4105ECR NmrA family GR129_RS20630 ENOG4105DQU oxidoreductase, subunit beta GR129_RS20635 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GR129_RS20640 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS20655 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GR129_RS20660 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20665 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GR129_RS20670 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GR129_RS20675 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20680 ENOG4107YX3 NADH dehydrogenase subunit j GR129_RS20685 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20695 ENOG4105C8S subunit m GR129_RS20700 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GR129_RS20705 ENOG4105D0M Protease HtpX homolog GR129_RS20720 ENOG4105Y3U Transglycosylase-associated protein GR129_RS20725 ENOG4108VPT UPF0234 protein GR129_RS20745 ENOG4107ZVI PhiRv2 prophage protein GR129_RS20830 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GR129_RS20845 ENOG4105NAF rna polymerase sigma factor GR129_RS20885 ENOG4105WDJ 50S ribosomal protein L33 GR129_RS20890 ENOG410900P UPF0336 protein GR129_RS20935 ENOG4107R4N Cell wall formation (By similarity) GR129_RS20960 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GR129_RS20970 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GR129_RS20980 ENOG4108VZM 50s ribosomal protein L10 GR129_RS20985 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GR129_RS20990 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GR129_RS20995 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GR129_RS21000 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GR129_RS21005 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GR129_RS21010 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GR129_RS21065 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GR129_RS21070 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GR129_RS21075 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GR129_RS21080 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GR129_RS21085 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GR129_RS21090 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GR129_RS21095 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GR129_RS21100 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GR129_RS21105 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GR129_RS21110 ENOG41082SA 50s ribosomal protein l29 GR129_RS21115 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GR129_RS21120 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GR129_RS21125 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GR129_RS21130 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GR129_RS21135 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GR129_RS21145 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GR129_RS21150 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GR129_RS21155 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GR129_RS21160 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GR129_RS21165 ENOG410849U 50S ribosomal protein L30 GR129_RS21170 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GR129_RS21180 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GR129_RS21190 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GR129_RS21195 ENOG41067V7 50S ribosomal protein L36 GR129_RS21200 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GR129_RS21205 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GR129_RS21210 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GR129_RS21215 ENOG4108ZT0 50S ribosomal protein l17 GR129_RS21220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GR129_RS21230 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GR129_RS21235 ENOG4108UJD 30S ribosomal protein S9 GR129_RS21240 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GR129_RS21245 ENOG4105CS9 pantothenic acid kinase GR129_RS21255 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GR129_RS21260 ENOG4105CHR reductase GR129_RS21275 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GR129_RS21280 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GR129_RS21285 ENOG4108097 ATP-binding protein GR129_RS21305 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GR129_RS21350 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GR129_RS21360 ENOG4105EMU Dehydrogenase GR129_RS21370 ENOG4105DND Transcriptional regulator GR129_RS21375 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR129_RS21380 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS21385 ENOG4108MMM RNA Polymerase GR129_RS21395 ENOG4107QVP Dehydrogenase GR129_RS21405 ENOG4107QQG Dehydrogenase GR129_RS21410 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GR129_RS21420 ENOG4105D9P serine threonine protein kinase GR129_RS21425 ENOG4107TPY serine threonine protein kinase GR129_RS21430 ENOG4108UGD Serine Threonine protein kinase GR129_RS21440 ENOG4108K01 transcriptional regulator GR129_RS21445 ENOG4107U32 Beta-lactamase domain protein GR129_RS21450 ENOG4108UGD Serine Threonine protein kinase GR129_RS21455 ENOG4105C26 Dehydrogenase GR129_RS21470 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GR129_RS21510 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS21530 ENOG41061JJ Peptidase family M23 GR129_RS21555 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GR129_RS21565 ENOG4105DEG Vwa containing coxe family protein GR129_RS21570 ENOG4105CMV Succinyl-CoA synthetase subunit beta GR129_RS21600 ENOG4105DC1 bifunctional purine biosynthesis protein purh GR129_RS21625 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GR129_RS21640 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GR129_RS21645 ENOG4105C57 major facilitator superfamily GR129_RS21655 ENOG4105C26 Dehydrogenase GR129_RS21665 ENOG4108IJ7 Glycine betaine GR129_RS21670 ENOG4108HQS Glycine betaine GR129_RS21685 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GR129_RS21690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GR129_RS21710 ENOG4106032 Glutathionylspermidine synthase GR129_RS21715 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GR129_RS21720 ENOG4105C31 Tryptophanyl-tRNA synthetase GR129_RS21735 ENOG4107H3J ribonuclease GR129_RS21760 ENOG4108RZE Tetr family transcriptional regulator GR129_RS21780 ENOG4108J01 L-aspartate oxidase GR129_RS21800 ENOG4105E2D ec 3.2.1.52 GR129_RS21825 ENOG4108MMM RNA Polymerase GR129_RS21845 ENOG4108NIW Leucine export protein LeuE GR129_RS21850 ENOG4107SCK Monooxygenase GR129_RS21870 ENOG4105K64 Glycosyl transferase, family 2 GR129_RS21880 ENOG4105F0R Cytidylyltransferase GR129_RS21885 ENOG4105D2T synthase GR129_RS21900 ENOG4107RM1 amidohydrolase GR129_RS21905 ENOG4105DIH basic membrane GR129_RS21910 ENOG4108JQ9 ABC transporter GR129_RS21950 ENOG4105D94 Major Facilitator Superfamily GR129_RS21955 ENOG4107RSM transcriptional regulator GR129_RS21965 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GR129_RS21990 ENOG41065SU Two-component system sensor kinase GR129_RS21995 ENOG4108KXV response regulator GR129_RS22000 ENOG4105NAF rna polymerase sigma factor GR129_RS22015 ENOG4105C26 Dehydrogenase GR129_RS22020 ENOG4105C26 Dehydrogenase GR129_RS22025 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GR129_RS22035 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GR129_RS22060 ENOG4108JIK carboxylase GR129_RS22070 ENOG4107WR6 Maf-like protein GR129_RS22085 ENOG4105D8K carboxyl transferase GR129_RS22100 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GR129_RS22110 ENOG4108QER Adenylate cyclase GR129_RS22120 ENOG4105E39 Enoyl-CoA hydratase GR129_RS22125 ENOG4105KDM Diguanylate cyclase with gaf sensor GR129_RS22130 ENOG4105C84 Histidine ammonia-lyase GR129_RS22160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GR129_RS22170 ENOG4105DQ4 alcohol dehydrogenase GR129_RS22195 ENOG4105NAF rna polymerase sigma factor GR129_RS22205 ENOG4105C7B Threonine dehydratase GR129_RS22210 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GR129_RS22220 ENOG4105T1M mycothiol conjugate amidase mca GR129_RS22245 ENOG4105C7Z Conserved Protein GR129_RS22270 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GR129_RS22280 ENOG4105CHM Aminotransferase GR129_RS22310 ENOG4108FUF Transcriptional regulator, IclR family GR129_RS22315 ENOG4105KME endoribonuclease L-psp GR129_RS22375 ENOG4107QMS site-determining protein GR129_RS22405 ENOG4105RAK Histidine kinase GR129_RS22410 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS22430 ENOG4107QKZ Ompa motb domain protein GR129_RS22450 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GR129_RS22455 ENOG4108IAB Phoh family GR129_RS22470 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GR129_RS22475 ENOG4105D3R alkyl hydroperoxide reductase GR129_RS22490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GR129_RS22500 ENOG4105BZ4 penicillin-binding protein GR129_RS22515 ENOG4105C9Q fumarate hydratase class II GR129_RS22520 ENOG4107GFK fumarate GR129_RS22530 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR129_RS22545 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GR129_RS22550 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GR129_RS22555 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GR129_RS22560 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GR129_RS22575 ENOG4105C3G gtp-binding protein GR129_RS22595 ENOG4107ZVI PhiRv2 prophage protein GR129_RS22610 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GR129_RS22620 ENOG4105DMQ Methyltransferase GR129_RS22655 ENOG4108F3G Type I restriction-modification system, R subunit GR129_RS22665 ENOG4105CVR type I restriction-modification system GR129_RS22725 ENOG4105CI3 gtp-binding protein typa GR129_RS22735 ENOG4108J59 Extracellular solute-binding protein, family 5 GR129_RS22745 ENOG4105C3U ABC transporter GR129_RS22750 ENOG4108JQ7 (ABC) transporter GR129_RS22760 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase GR129_RS22765 ENOG4108JQ7 (ABC) transporter GR129_RS22780 ENOG4105DEF Extracellular solute-binding protein, family 5 GR129_RS22785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR129_RS22790 ENOG4108J59 Extracellular solute-binding protein, family 5 GR129_RS22795 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GR129_RS22800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR129_RS22805 ENOG4105C3U ABC transporter GR129_RS22810 ENOG4108JQ7 (ABC) transporter GR129_RS22840 ENOG4108M15 ABC transporter GR129_RS22850 ENOG4105BZU Histidine kinase GR129_RS22855 ENOG4108S01 response regulator GR129_RS22870 ENOG4108Z4U Ferredoxin GR129_RS22890 ENOG4107R4C succinyl-diaminopimelate desuccinylase GR129_RS22895 ENOG4108URH decarboxylase GR129_RS22900 ENOG4105EEI dihydropteroate synthase GR129_RS22910 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GR129_RS22915 ENOG4105CGU Enoyl-CoA hydratase GR129_RS22930 ENOG4105DU6 RNA polymerase GR129_RS22940 ENOG4105C0H protease GR129_RS22945 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GR129_RS22980 ENOG4105D7N magnesium and cobalt transport protein CorA GR129_RS22990 ENOG4105DXB Major Facilitator superfamily GR129_RS23005 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GR129_RS23065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR129_RS23080 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GR129_RS23105 ENOG4105K56 Transcriptional regulator GR129_RS23140 ENOG4107QSE Dipeptidase GR129_RS23145 ENOG4105E09 nadh pyrophosphatase GR129_RS23165 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR129_RS23230 ENOG41063PX domain protein GR129_RS23240 ENOG4105DJZ UPF0182 protein GR129_RS23275 ENOG4107TK4 histidinol-phosphate phosphatase GR129_RS23285 ENOG4105KPY Small multidrug resistance protein GR129_RS23295 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GR129_RS23305 ENOG4108RAV Conserved protein GR129_RS23315 ENOG4105EMN RNA polymerase sigma factor GR129_RS23320 ENOG4105WMN AntiSigma factor GR129_RS23330 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GR129_RS23340 ENOG41068W2 Cytochrome p-450 GR129_RS23355 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GR129_RS23360 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GR129_RS23375 ENOG4105FDP GntR family transcriptional regulator GR129_RS23395 ENOG4105CBD Diacylglycerol kinase GR129_RS23410 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GR129_RS23425 ENOG4105K6H D-cysteine desulfhydrase GR129_RS23430 ENOG4105ESN nucleotide-binding protein GR129_RS23465 ENOG4105D3W isochorismatase GR129_RS23500 ENOG4108VEQ Superoxide dismutase GR129_RS23515 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GR129_RS23520 ENOG4105CDA abc transporter atp-binding protein GR129_RS23535 ENOG4105C6K Malic enzyme GR129_RS23540 ENOG4105CB2 alcohol dehydrogenase GR129_RS23555 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GR129_RS23560 ENOG4105EB3 Histidine kinase GR129_RS23565 ENOG4108PYU two-component system response regulator GR129_RS23580 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GR129_RS23640 ENOG4105K4H Nlp p60 protein GR129_RS23655 ENOG41090B9 response to stress GR129_RS23685 ENOG4105CJN penicillin-binding protein GR129_RS23715 ENOG4105DQE DNA ligase GR129_RS23720 ENOG4105FDF Could be involved in DNA repair (By similarity) GR129_RS23745 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GR129_RS23755 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS23800 ENOG4108R96 Methyltransferase, YaeB family GR129_RS23805 ENOG4105D4P Coproporphyrinogen iii oxidase GR129_RS23810 ENOG4105C28 cystathionine GR129_RS23825 ENOG4105CPF Cell wall formation (By similarity) GR129_RS23830 ENOG4108R96 Methyltransferase, YaeB family GR129_RS23835 ENOG4105CHM Aminotransferase GR129_RS23865 ENOG4105ETX regulatoR GR129_RS23870 ENOG4105C75 arginyL-tRNA synthetase GR129_RS23875 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GR129_RS23880 ENOG4105D6E homoserine dehydrogenase GR129_RS23885 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GR129_RS23890 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GR129_RS23905 ENOG4105VFB Binds the 23S rRNA (By similarity) GR129_RS23910 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GR129_RS23915 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR129_RS23925 ENOG4107ZF2 Phosphatase GR129_RS23930 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GR129_RS23935 ENOG4105ESV Glycosyl transferase, family 4 GR129_RS23940 ENOG4105Z3P ATP synthase GR129_RS23950 ENOG4105ZA1 atp synthase GR129_RS23955 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GR129_RS23960 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GR129_RS23965 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GR129_RS23975 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GR129_RS23980 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GR129_RS24015 ENOG410630P Transcriptional regulator GR129_RS24020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR129_RS24035 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GR129_RS24090 ENOG4105CHU acetyl-coa acetyltransferase GR129_RS24150 ENOG4105WX6 Membrane GR129_RS24155 ENOG4105D5P Methylmalonyl-coA mutase GR129_RS24190 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GR129_RS24195 ENOG4105C6K Malic enzyme GR129_RS24200 ENOG4105CTQ phosphohexokinase GR129_RS24210 ENOG4108MRH transcriptional regulatory protein GR129_RS24215 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GR129_RS24220 ENOG4107QJT sodium dicarboxylate symporter GR129_RS24230 ENOG4105C57 major facilitator superfamily GR129_RS24255 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GR129_RS24260 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GR129_RS24270 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GR129_RS24275 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GR129_RS24300 ENOG4105BZU Histidine kinase GR129_RS24310 ENOG4105CJ1 ABC, transporter GR129_RS24315 ENOG4105BZ1 (ABC) transporter GR129_RS24320 ENOG4105BZ1 (ABC) transporter GR129_RS24340 ENOG4105CND Glycosyl transferase, family 2 GR129_RS24360 ENOG4105S7A ErfK ybiS ycfS ynhG family protein GR129_RS24370 ENOG4105E39 Enoyl-CoA hydratase GR129_RS24400 ENOG4107YXZ hydrolase, family 25 GR129_RS24415 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GR129_RS24420 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GR129_RS24425 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GR129_RS24445 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GR129_RS24460 ENOG4105C3U ABC transporter GR129_RS24465 ENOG4108JQ7 (ABC) transporter GR129_RS24475 ENOG4105EN6 Membrane GR129_RS24495 ENOG4106NZI LysR family Transcriptional regulator GR129_RS24535 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GR129_RS24550 ENOG4108URH decarboxylase GR129_RS24555 ENOG4105EMU Dehydrogenase GR129_RS24565 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GR129_RS24590 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GR129_RS24595 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GR129_RS24605 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GR129_RS24610 ENOG4105EYF MMPL domain protein GR129_RS24635 ENOG4105CPC Aldo Keto reductase GR129_RS24660 ENOG4108ZP8 Acetolactate synthase small subunit GR129_RS24665 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GR129_RS24675 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GR129_RS24685 ENOG4105C26 Dehydrogenase GR129_RS24705 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GR129_RS24710 ENOG4105CM2 brancheD-chain amino acid aminotransferase GR129_RS24720 ENOG4105CQM Urea amidohydrolase subunit alpha GR129_RS24725 ENOG4105DWY Agmatine deiminase GR129_RS24740 ENOG4108RF4 Tetr family transcriptional regulator GR129_RS24745 ENOG4105CSH Transporter GR129_RS24750 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GR129_RS24785 ENOG4108YYC ycei family GR129_RS24790 ENOG4105D8K carboxyl transferase GR129_RS24815 ENOG4105GWZ Roadblock lc7 family protein GR129_RS24835 ENOG4105GWZ Roadblock lc7 family protein GR129_RS24855 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GR129_RS24895 ENOG41069M3 Transcriptional regulator GR129_RS24900 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GR129_RS24905 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GR129_RS24915 ENOG4105K70 DNA-binding protein GR129_RS24925 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) GR129_RS24935 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GR129_RS24940 ENOG4105CPF Cell wall formation (By similarity) GR129_RS24960 ENOG4105DWF phosphomethylpyrimidine kinase GR129_RS24975 ENOG4105VB9 50S ribosomal protein l28 GR129_RS24980 ENOG4105DP4 dak2 domain fusion protein ylov GR129_RS24990 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GR129_RS25000 ENOG4106H78 methyltransferase GR129_RS25005 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GR129_RS25020 ENOG41084BZ 50S ribosomal protein L32 GR129_RS25025 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GR129_RS25030 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GR129_RS25035 ENOG4105KVH Transcriptional regulator GR129_RS25050 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GR129_RS25085 ENOG4105ETS cytosine purines uracil thiamine allantoin GR129_RS25115 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GR129_RS25125 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GR129_RS25140 ENOG4105K5M 30s ribosomal protein S16 GR129_RS25145 ENOG41082KU UPF0109 protein GR129_RS25150 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GR129_RS25155 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GR129_RS25160 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GR129_RS25175 ENOG4107QYR Signal peptidase i GR129_RS25185 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GR129_RS25195 ENOG41080R2 UPF0102 protein GR129_RS25200 ENOG4105C0P Mg chelatase subunit ChlI GR129_RS25210 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS25225 ENOG4105CE9 30S ribosomal protein S2 GR129_RS25235 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GR129_RS25240 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GR129_RS25245 ENOG4105KNE Phosphatidate cytidylyltransferase GR129_RS25255 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GR129_RS25265 ENOG4105ECW sulfate abc transporter GR129_RS25270 ENOG4108UCS ABC, transporter GR129_RS25290 ENOG4108I0Y (ABC) transporter GR129_RS25295 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GR129_RS25305 ENOG4105C26 Dehydrogenase GR129_RS25320 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GR129_RS25325 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GR129_RS25340 ENOG4105EHZ conserved protein UCP016719 GR129_RS25355 ENOG4107MMM Anti-sigma-factor antagonist GR129_RS25360 ENOG4105FUA antagonist GR129_RS25365 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GR129_RS25375 ENOG4105BZU Histidine kinase GR129_RS25385 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GR129_RS25390 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GR129_RS25415 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GR129_RS25420 ENOG4105F38 ABC transporter, permease GR129_RS25425 ENOG4105D38 putrescine abc transporter GR129_RS25430 ENOG4105CJP fad dependent oxidoreductase GR129_RS25510 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GR129_RS25515 ENOG4105DZP Membrane-associated zinc metalloprotease GR129_RS25520 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GR129_RS25580 ENOG4108Z7F N-acetyltransferase GR129_RS25585 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GR129_RS25590 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GR129_RS25595 ENOG4108KB2 LysR family Transcriptional regulator GR129_RS25600 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase GR129_RS25615 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GR129_RS25630 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GR129_RS25640 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GR129_RS25645 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GR129_RS25710 ENOG4105EC2 ftsk spoIIIe GR129_RS25725 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GR129_RS25730 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GR129_RS25735 ENOG4105C1V Peptidase, M16 GR129_RS25740 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GR129_RS25760 ENOG4107V6K Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) GR129_RS25765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GR129_RS25770 ENOG4105CN5 Metallo-Beta-Lactamase GR129_RS25815 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GR129_RS25830 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GR129_RS25840 ENOG4105CEV competence damage-inducible protein GR129_RS25845 ENOG4105WBV Transcriptional regulator GR129_RS25850 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GR129_RS25860 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GR129_RS25865 ENOG4107QRT dEAD DEAH box helicase GR129_RS25895 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GR129_RS25900 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR129_RS25930 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GR129_RS25945 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GR129_RS25955 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GR129_RS25965 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GR129_RS25970 ENOG4105DRP amino acid AbC transporter GR129_RS25975 ENOG4108Q1T ABC transporter GR129_RS25980 ENOG4107UBR Extracellular solute-binding protein family 3 GR129_RS25985 ENOG4105CDA abc transporter atp-binding protein GR129_RS25990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GR129_RS25995 ENOG4105EB3 Histidine kinase GR129_RS26020 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GR129_RS26040 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GR129_RS26050 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GR129_RS26055 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GR129_RS26065 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GR129_RS26095 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GR129_RS26100 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GR129_RS26105 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GR129_RS26125 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GR129_RS26135 ENOG4107SQU synthase GR129_RS26140 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GR129_RS26155 ENOG4105C9U ATP-dependent DNA helicase RecQ GR129_RS26175 ENOG4105C6F GntR Family Transcriptional Regulator GR129_RS26180 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS26195 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GR129_RS26220 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS26230 ENOG4107QN1 sodium solute GR129_RS26235 ENOG4108MRH transcriptional regulatory protein GR129_RS26245 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GR129_RS26265 ENOG4105BZN citrate synthase GR129_RS26270 ENOG4105BZN citrate synthase GR129_RS26280 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GR129_RS26300 ENOG4105DRR Transcriptional regulator, GntR family GR129_RS26305 ENOG410849S phosphocarrier protein (HPr) GR129_RS26310 ENOG4105CD5 CoA-binding domain protein GR129_RS26325 ENOG4107W53 thymidine kinase GR129_RS26360 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GR129_RS26370 ENOG4105F44 Two component transcriptional regulator, winged helix family GR129_RS26375 ENOG4106F60 Histidine kinase GR129_RS26400 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GR129_RS26435 ENOG4107VEG TrkA-N domain protein GR129_RS26440 ENOG4105C0X amino acid GR129_RS26445 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GR129_RS26450 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GR129_RS26470 ENOG41087PP glycosyltransferase MGT family GR129_RS26495 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GR129_RS26515 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS26540 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GR129_RS26550 ENOG4105DYW oxidoreductase GR129_RS26560 ENOG4105BZ1 (ABC) transporter GR129_RS26580 ENOG4105C83 adenylosuccinate lyase GR129_RS26590 ENOG4105CH7 arginosuccinase GR129_RS26605 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GR129_RS26650 ENOG4106IBS oxygenase GR129_RS26660 ENOG4105WQT MbtH domain protein GR129_RS26690 ENOG4105C19 ABC transporter GR129_RS26695 ENOG4105BZU Histidine kinase GR129_RS26700 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS26705 ENOG4105JNK Glycosyl transferase (Group 1 GR129_RS26810 ENOG4105FS7 Transcriptional regulator GR129_RS26880 ENOG4107S1Q Phosphatase GR129_RS26895 ENOG4105CEU Arginine dihydrolase GR129_RS26900 ENOG4105DBV ornithine carbamoyltransferase GR129_RS26905 ENOG4105CUB amino acid GR129_RS26915 ENOG4105CGU Enoyl-CoA hydratase GR129_RS26995 ENOG4105D8K carboxyl transferase GR129_RS27025 ENOG4108Z4U Ferredoxin GR129_RS27030 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GR129_RS27035 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GR129_RS27050 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GR129_RS27055 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR129_RS27105 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS27120 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR129_RS27155 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GR129_RS27200 ENOG4105FDP GntR family transcriptional regulator GR129_RS27220 ENOG4105D17 glycoside hydrolase, family 3 domain protein GR129_RS27250 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GR129_RS27285 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GR129_RS27290 ENOG4105EW9 transcriptional regulator AsnC family GR129_RS27295 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GR129_RS27305 ENOG4107QM5 aconitate hydratase GR129_RS27375 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GR129_RS27380 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GR129_RS27385 ENOG4105E2R ROK family GR129_RS27390 ENOG4105DFW ABC transporter GR129_RS27395 ENOG4105C2J ABC transporter GR129_RS27400 ENOG4107RNG ABC transporter GR129_RS27410 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GR129_RS27415 ENOG4105CUB amino acid GR129_RS27430 ENOG4105PNM synthesis protein GR129_RS27465 ENOG4105CHU acetyl-coa acetyltransferase GR129_RS27470 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GR129_RS27485 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GR129_RS27495 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GR129_RS27500 ENOG4105C1Q protoporphyrinogen oxidase GR129_RS27505 ENOG4107JTW chlorite dismutase GR129_RS27520 ENOG4105E18 UPF0276 protein GR129_RS27555 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR129_RS27590 ENOG4108IUX (ABC) transporter GR129_RS27620 ENOG4107B2H carbonic anhydrase GR129_RS27640 ENOG4105DFU Cell wall formation (By similarity) GR129_RS27645 ENOG4105E0X reductase GR129_RS27650 ENOG4108IJ8 ABC transporter GR129_RS27655 ENOG4105E90 ABC transporter GR129_RS27660 ENOG4105E90 ABC transporter GR129_RS27690 ENOG41064MX Tetr family transcriptional regulator GR129_RS27710 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein GR129_RS27785 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GR129_RS27805 ENOG4108IY8 ABC, transporter GR129_RS27830 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) GR129_RS27835 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GR129_RS27845 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GR129_RS27850 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GR129_RS27860 ENOG4107RR1 TRANSCRIPTIONal GR129_RS27865 ENOG4105CSU acyl-Coa dehydrogenase GR129_RS27880 ENOG4105CR4 methylisocitrate lyase GR129_RS27890 ENOG4105EBR Carboxylesterase GR129_RS27895 ENOG4108VQJ O-methyltransferase GR129_RS27900 ENOG4105EMU Dehydrogenase GR129_RS27915 ENOG4108J5H Homocysteine s-methyltransferase GR129_RS27935 ENOG4105QE3 oxidoreductase GR129_RS27960 ENOG4105CZQ inner membrane transport protein YdhC GR129_RS27965 ENOG4106NZI LysR family Transcriptional regulator GR129_RS27980 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GR129_RS27990 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GR129_RS28005 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GR129_RS28025 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GR129_RS28055 ENOG4105C7K acetolactate synthase GR129_RS28070 ENOG4105DRR Transcriptional regulator, GntR family GR129_RS28095 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GR129_RS28100 ENOG4105C7N Xanthine uracil vitamin C permease GR129_RS28120 ENOG410829K Lysine exporter protein (Lyse ygga) GR129_RS28130 ENOG4108ZJ4 polysaccharide deacetylase GR129_RS28140 ENOG4108RU0 short-chain dehydrogenase reductase GR129_RS28150 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GR129_RS28165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GR129_RS28170 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS28180 ENOG41060W2 glyoxylate carboligase GR129_RS28195 ENOG4105CH6 catalase GR129_RS28200 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GR129_RS28205 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GR129_RS28225 ENOG4105VT2 5-hydroxyisourate hydrolase GR129_RS28235 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GR129_RS28260 ENOG4108ZM9 phosphoglycerate mutase GR129_RS28270 ENOG4105CHM Aminotransferase GR129_RS28315 ENOG4105F0K SARP family transcriptional regulator GR129_RS28345 ENOG4107HP6 Transcriptional regulator GR129_RS28355 ENOG4105DHG Allantoate amidinohydrolase GR129_RS28390 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GR129_RS28395 ENOG4105FDP GntR family transcriptional regulator GR129_RS28405 ENOG41062B0 ABC transporter, permease GR129_RS28410 ENOG4105C2J ABC transporter GR129_RS28415 ENOG4105DKQ ROK family GR129_RS28425 ENOG4105C0D helicase GR129_RS28440 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GR129_RS28445 ENOG4105CBC glutamate synthase GR129_RS28450 ENOG4105C5S asparaginyl-tRNA synthetase GR129_RS28455 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GR129_RS28500 ENOG4105E0F Histidine kinase GR129_RS28560 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GR129_RS28595 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GR129_RS28620 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GR129_RS28645 ENOG4105C8Y Acetylornithine aminotransferase GR129_RS28660 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GR129_RS28670 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GR129_RS28710 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GR129_RS28720 ENOG4105C0X amino acid GR129_RS28730 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GR129_RS28735 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GR129_RS28740 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GR129_RS28770 ENOG4107RSM transcriptional regulator GR129_RS28815 ENOG4105DAE Methylenetetrahydrofolate reductase GR129_RS28825 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GR129_RS28830 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GR129_RS28845 ENOG4105BZW Glycerate kinase GR129_RS28855 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GR129_RS28860 ENOG4105C1G acyl-Coa dehydrogenase GR129_RS28870 ENOG4105CI0 Citrate lyase GR129_RS28875 ENOG4105RFZ Methylmalonyl-coA mutase GR129_RS28880 ENOG4105EE1 crotonyl-CoA reductase GR129_RS28890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR129_RS28905 ENOG4107U9T Pfam:Ribonuclease_BN GR129_RS28935 ENOG4108Q50 Histidine kinase GR129_RS28940 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GR129_RS28945 ENOG4108ME1 Peptidase M55 D-aminopeptidase GR129_RS28950 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GR129_RS28960 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GR129_RS28985 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GR129_RS29005 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GR129_RS29030 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GR129_RS29040 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GR129_RS29065 ENOG4105C5H ABC transporter GR129_RS29110 ENOG4105E8R UPF0173 metal-dependent hydrolase GR129_RS29140 ENOG410842T Pterin carbinolamine dehydratase GR129_RS29145 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GR129_RS29175 ENOG4105CV8 reductase GR129_RS29185 ENOG4105DUM transcriptional regulator, lysR family GR129_RS29190 ENOG4105DHU Bile acid GR129_RS29195 ENOG4108478 ec 3.2.1.18 GR129_RS29205 ENOG4108VHT MarR family transcriptional regulator GR129_RS29215 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GR129_RS29220 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GR129_RS29235 ENOG4108C33 Resolvase GR129_RS29250 ENOG4105N1N Cupin superfamily protein GR129_RS29270 ENOG4105CWX Alpha-1,2-mannosidase GR129_RS29275 ENOG4105GTG Isochorismatase GR129_RS29310 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR129_RS29370 ENOG4105D56 permease protein GR129_RS29375 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GR129_RS29405 ENOG410905P Pyridoxamine 5-phosphate GR129_RS29410 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GR129_RS29425 ENOG4107TB6 phosphoglycerate mutase GR129_RS29430 ENOG4108J5G 6-phosphogluconate dehydrogenase GR129_RS29435 ENOG4107QP8 phosphohexose isomerase GR129_RS29450 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GR129_RS29475 ENOG4105F8D glycoside hydrolase family 4 GR129_RS29545 ENOG4105CSH Transporter GR129_RS29570 ENOG4105DQE DNA ligase GR129_RS29585 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GR129_RS29595 ENOG4106V2I dimethylaminohydrolase GR129_RS29600 ENOG4105C5H ABC transporter GR129_RS29605 ENOG4105KF0 sporulation and cell division protein, SsgA GR129_RS29625 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GR129_RS29635 ENOG4105EG6 Saccharopine dehydrogenase GR129_RS29640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GR129_RS29645 ENOG4105CHU acetyl-coa acetyltransferase GR129_RS29650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GR129_RS29685 ENOG4105C5H ABC transporter GR129_RS29695 ENOG4105BZM domain protein GR129_RS29730 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GR129_RS29755 ENOG4108MDK Dehydrogenase GR129_RS29775 ENOG4105EY8 ABC transporter GR129_RS29780 ENOG4105FBD synthase GR129_RS29790 ENOG4107S11 squalene-associated FAD-dependent desaturase GR129_RS29800 ENOG4105EWU Squalene--hopene cyclase GR129_RS29815 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GR129_RS29845 ENOG41090WU lipolytic protein G-D-S-L family GR129_RS29855 ENOG4105F0K SARP family transcriptional regulator GR129_RS29885 ENOG4105CJ1 ABC, transporter GR129_RS29890 ENOG4108KYE ABC-2 type transporter GR129_RS29905 ENOG4105CH2 amidohydrolase GR129_RS29965 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GR129_RS29970 ENOG4106NZI LysR family Transcriptional regulator GR129_RS30000 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GR129_RS30005 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GR129_RS30055 ENOG4105F0K SARP family transcriptional regulator GR129_RS30080 ENOG4105C5F glutamine synthetase GR129_RS30090 ENOG4108HCJ Hydrolase GR129_RS30115 ENOG4105E5G Alpha beta hydrolase fold GR129_RS30125 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS30165 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS30170 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GR129_RS30175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GR129_RS30190 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GR129_RS30195 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GR129_RS30200 ENOG4105CHR reductase GR129_RS30245 ENOG4105C12 Phosphoribosylglycinamide synthetase GR129_RS30280 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GR129_RS30305 ENOG4105BZ1 (ABC) transporter GR129_RS30310 ENOG4105BZ1 (ABC) transporter GR129_RS30335 ENOG4105C31 Tryptophanyl-tRNA synthetase GR129_RS30350 ENOG4105F0K SARP family transcriptional regulator GR129_RS30395 ENOG4105CMR udp-glucose 4-epimerase GR129_RS30405 ENOG4105E2A Dehydrogenase GR129_RS30450 ENOG4105Q56 cytochrome P450 GR129_RS30475 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GR129_RS30540 ENOG4105C7K acetolactate synthase GR129_RS30580 ENOG4105EDW glycosyl transferase, family 39 GR129_RS30590 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GR129_RS30600 ENOG4105DV0 amidase (EC 3.5.1.4 GR129_RS30615 ENOG4105C7W Xanthine dehydrogenase GR129_RS30635 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GR129_RS30640 ENOG4105ENE Histidine kinase GR129_RS30645 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS30650 ENOG4105C0D helicase GR129_RS30655 ENOG4105CGD Nad-dependent epimerase dehydratase GR129_RS30665 ENOG4105D5Q Arginine ornithine antiporter GR129_RS30670 ENOG4105ETS cytosine purines uracil thiamine allantoin GR129_RS30690 ENOG4105CDA abc transporter atp-binding protein GR129_RS30695 ENOG4105EAB amino acid AbC transporter GR129_RS30705 ENOG4105CPU Monooxygenase GR129_RS30710 ENOG4105CPU Monooxygenase GR129_RS30720 ENOG4106S2D Transcriptional regulator GR129_RS30800 ENOG4106A3M Cytochrome p-450 GR129_RS30815 ENOG4105DWV Homoserine O-trans-acetylase GR129_RS30830 ENOG4105E9K Isocitrate dehydrogenase GR129_RS30835 ENOG4105M0C cytoplasmic protein GR129_RS30840 ENOG4105D64 Mechanosensitive ion channel GR129_RS30845 ENOG4105CUB amino acid GR129_RS30855 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GR129_RS30860 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GR129_RS30875 ENOG41060WC Enoyl-CoA hydratase GR129_RS30885 ENOG4105BZ1 (ABC) transporter GR129_RS30905 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GR129_RS30910 ENOG4105C7W Xanthine dehydrogenase GR129_RS30970 ENOG4105C26 Dehydrogenase GR129_RS30980 ENOG4108IPT Naphthoate synthase GR129_RS31020 ENOG4105CR4 methylisocitrate lyase GR129_RS31040 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GR129_RS31050 ENOG4107R9S Malate synthase GR129_RS31070 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GR129_RS31080 ENOG4105C0W non-ribosomal peptide synthetase GR129_RS31135 ENOG4107RN3 metallophosphoesterase GR129_RS31165 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GR129_RS31170 ENOG41068HZ 50S ribosomal protein L32 GR129_RS31175 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GR129_RS31185 ENOG4105NRA 50s ribosomal protein l31 type b GR129_RS31200 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GR129_RS31205 ENOG4105CH6 catalase GR129_RS31210 ENOG4108HUF Transporter GR129_RS31220 ENOG4105TVJ transport system, permease GR129_RS31225 ENOG4105DQ5 transport system permease protein GR129_RS31235 ENOG4105BZ1 (ABC) transporter GR129_RS31260 ENOG4105C0I Conserved Protein GR129_RS31335 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GR129_RS31355 ENOG4105CWX Alpha-1,2-mannosidase GR129_RS31380 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GR129_RS31415 ENOG4105CUB amino acid GR129_RS31435 ENOG4105CRK lysyL-tRNA synthetase GR129_RS31470 ENOG4105BZU Histidine kinase GR129_RS31475 ENOG4105C5Q Transcriptional regulator GR129_RS31490 ENOG4105E33 succinate dehydrogenase GR129_RS31520 ENOG4105DEN Luciferase family GR129_RS31530 ENOG4105WKW Pfam:DUF1458 GR129_RS31540 ENOG41067HS methyltransferase GR129_RS31545 ENOG4108V75 Glutamine amidotransferase GR129_RS31550 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process GR129_RS31590 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GR129_RS31620 ENOG4108IUW ABC transporter GR129_RS31645 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GR129_RS31660 ENOG4105RHY Pfam:UPF0157 GR129_RS31670 ENOG4105CIH Imidazole acetol-phosphate transaminase GR129_RS31700 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS31705 ENOG41080RH Thioredoxin GR129_RS31715 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GR129_RS31725 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GR129_RS31745 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GR129_RS31780 ENOG4108JPZ Monovalent cation H antiporter subunit D GR129_RS31800 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GR129_RS31805 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GR129_RS31820 ENOG4105CHH sulfate transporter GR129_RS31840 ENOG4105KJJ Uncharacterized ACR, COG1993 GR129_RS31845 ENOG41083TI Protein CrcB homolog GR129_RS31850 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GR129_RS31900 ENOG4106A3M Cytochrome p-450 GR129_RS31925 ENOG4108S01 response regulator GR129_RS31930 ENOG4107WYG Transcriptional regulator, luxr family GR129_RS31935 ENOG4105EC3 peptidase S51, dipeptidase E GR129_RS31945 ENOG4105WQT MbtH domain protein GR129_RS31960 ENOG4105C7B Threonine dehydratase GR129_RS31985 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GR129_RS32000 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GR129_RS32010 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GR129_RS32015 ENOG4105F0N pyrophosphate phospho-hydrolase GR129_RS32060 ENOG4105YVM Phosphoesterase, PA-phosphatase related GR129_RS32085 ENOG4105CI2 imidazolone-5-propionate hydrolase GR129_RS32115 ENOG4105CAS nag kinase GR129_RS32120 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GR129_RS32125 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GR129_RS32130 ENOG4105WQI isochorismatase GR129_RS32155 ENOG4105WQI isochorismatase GR129_RS32170 ENOG4105DQ5 transport system permease protein GR129_RS32175 ENOG4105TVJ transport system, permease GR129_RS32180 ENOG4105E0A ABC, transporter GR129_RS32190 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR129_RS32195 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GR129_RS32200 ENOG4105C3I Nad-dependent epimerase dehydratase GR129_RS32210 ENOG4105BZU Histidine kinase GR129_RS32225 ENOG4105E1F short-chain dehydrogenase reductase GR129_RS32255 ENOG4108D32 Methyltransferase GR129_RS32330 ENOG4105EUB pirin domain protein GR129_RS32340 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS32360 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GR129_RS32365 ENOG4105E90 ABC transporter GR129_RS32380 ENOG4108IJ8 ABC transporter GR129_RS32385 ENOG41080R8 Conserved Protein GR129_RS32390 ENOG4107QR9 Iron-sulfur cluster binding protein GR129_RS32395 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GR129_RS32405 ENOG4105E2A Dehydrogenase GR129_RS32410 ENOG4105DDN Pentapeptide repeat-containing protein GR129_RS32415 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GR129_RS32420 ENOG4108R86 Transcriptional regulator GR129_RS32430 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GR129_RS32480 ENOG4105DCG PHP domain protein GR129_RS32510 ENOG4105GND monovalent cation H antiporter subunit B GR129_RS32520 ENOG4105C8S subunit m GR129_RS32525 ENOG4105EDW glycosyl transferase, family 39 GR129_RS32530 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GR129_RS32560 ENOG4105CHF Glutathione S-transferase GR129_RS32565 ENOG4105PGM cation diffusion facilitator family transporter GR129_RS32575 ENOG4106YKD Cytochrome p-450 GR129_RS32610 ENOG4105F95 Monooxygenase GR129_RS32645 ENOG4105CPC Aldo Keto reductase GR129_RS32665 ENOG4108V5V Serine Threonine protein kinase GR129_RS32700 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GR129_RS32720 ENOG4105EMU Dehydrogenase GR129_RS32810 ENOG4108W6C Dehydrogenase GR129_RS32830 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GR129_RS32900 ENOG4105C87 Aminotransferase class I and II GR129_RS32920 ENOG4108IG5 Transcriptional regulator GR129_RS32925 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS33015 ENOG4105D3W isochorismatase GR129_RS33020 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR129_RS33030 ENOG410841Q phosphoesterase PA-phosphatase related protein GR129_RS33035 ENOG4105DQR SNARE associated Golgi GR129_RS33040 ENOG4105D9G High-affinity GR129_RS33055 ENOG4105BZP glycoside hydrolase 15-related GR129_RS33060 ENOG4105DND Transcriptional regulator GR129_RS33065 ENOG4107B2H carbonic anhydrase GR129_RS33070 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) GR129_RS33075 ENOG4107Y2X deaminase GR129_RS33080 ENOG4108Q50 Histidine kinase GR129_RS33095 ENOG4108N5B 2-phosphosulfolactate phosphatase GR129_RS33220 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GR129_RS33230 ENOG4106UDK Cellulose-binding, family II GR129_RS33265 ENOG4105EGE secreted protein GR129_RS33290 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GR129_RS33295 ENOG4105FUA antagonist GR129_RS33300 ENOG4107MMM Anti-sigma-factor antagonist GR129_RS33310 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR129_RS33315 ENOG4105FS7 Transcriptional regulator GR129_RS33335 ENOG4105MKU Transcriptional regulator GR129_RS33345 ENOG4105E1F short-chain dehydrogenase reductase GR129_RS33375 ENOG4105ETE Transcriptional regulator (LacI family GR129_RS33380 ENOG4105CYP glycoside hydrolase, family GR129_RS33390 ENOG4108VCT Sulfite exporter TauE/SafE GR129_RS33400 ENOG4107TPS domain protein GR129_RS33440 ENOG4105CT3 Monooxygenase GR129_RS33480 ENOG4107QQG Dehydrogenase GR129_RS33485 ENOG4107EG8 signal transduction protein with EFhand domain GR129_RS33495 ENOG4105EP9 oxidoreductase GR129_RS33535 ENOG4108QDE fad dependent oxidoreductase GR129_RS33540 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS33550 ENOG410846T CoA-transferase family III GR129_RS33555 ENOG4105CEY Amp-dependent synthetase and ligase GR129_RS33585 ENOG4105ESN nucleotide-binding protein GR129_RS33600 ENOG4105ETX regulatoR GR129_RS33605 ENOG41062D9 Histidine kinase GR129_RS33620 ENOG4105BZU Histidine kinase GR129_RS33635 ENOG4108E1C hydrolase GR129_RS33670 ENOG4105WH1 Two component transcriptional regulator luxr family GR129_RS33690 ENOG4105BZN citrate synthase GR129_RS33720 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GR129_RS33740 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GR129_RS33780 ENOG4105C1J atp-dependent rna helicase GR129_RS33785 ENOG4105VEQ Cold shock protein GR129_RS33840 ENOG4105VEQ Cold shock protein GR129_RS33860 ENOG41066UM arsR family transcriptional regulator GR129_RS33890 ENOG4107RSM transcriptional regulator GR129_RS33910 ENOG4105NAE bifunctional deaminase-reductase domain protein GR129_RS33985 ENOG4105CIR epoxide hydrolase GR129_RS34015 ENOG4105CHR reductase GR129_RS34035 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GR129_RS34045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GR129_RS34065 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GR129_RS34105 ENOG4108KB2 LysR family Transcriptional regulator GR129_RS34115 ENOG4107W2A UPF0173 metal-dependent hydrolase GR129_RS34140 ENOG4105C0R drug resistance transporter emrb qaca subfamily GR129_RS34150 ENOG4105C26 Dehydrogenase GR129_RS34225 ENOG4107RDB Major Facilitator GR129_RS34235 ENOG4108M32 ATP-grasp domain GR129_RS34285 ENOG4105CVN desaturase GR129_RS34295 ENOG4107WDG serine threonine protein kinase GR129_RS34335 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GR129_RS34390 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GR129_RS34405 ENOG4107MMM Anti-sigma-factor antagonist GR129_RS34410 ENOG4105FUA antagonist GR129_RS34415 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GR129_RS34435 ENOG4107S2Z UPF0761 membrane protein GR129_RS34520 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GR129_RS34525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GR129_RS34530 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GR129_RS34565 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GR129_RS34575 ENOG4105E98 transcriptional regulator DeoR family GR129_RS34585 ENOG4105DM4 PTS System GR129_RS34620 ENOG4105VCQ rubredoxin GR129_RS34650 ENOG4107RCI amp-dependent synthetase and ligase GR129_RS34845 ENOG4105FDF Could be involved in DNA repair (By similarity) GR129_RS34890 ENOG4105ZXU NLP P60 protein GR129_RS35080 ENOG4107YCY Transcriptional regulator GR129_RS35125 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GR129_RS35145 ENOG4107QJE Chromosome Partitioning Protein GR129_RS35150 ENOG4107RZZ dna polymerase iii epsilon subunit