locus-tag	class	description
NRO40_RS00035	COG2261	transglycosylase associated protein
NRO40_RS00080	COG0598	Magnesium transport protein CorA
NRO40_RS00180	COG3507	Belongs to the glycosyl hydrolase 43 family
NRO40_RS00200	COG2070	2-Nitropropane dioxygenase
NRO40_RS00200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NRO40_RS00220	COG0251	oxidation-reduction process
NRO40_RS00235	COG3940	Belongs to the glycosyl hydrolase 43 family
NRO40_RS00260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRO40_RS00270	COG3795	YCII-related domain
NRO40_RS00275	COG4941	Belongs to the sigma-70 factor family
NRO40_RS00285	COG3397	chitin binding
NRO40_RS00300	COG1869	D-ribose catabolic process
NRO40_RS00305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRO40_RS00315	COG1129	ABC transporter
NRO40_RS00330	COG0640	Transcriptional regulator
NRO40_RS00360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRO40_RS00415	COG2223	nitrite transmembrane transporter activity
NRO40_RS00430	COG0657	acetylesterase activity
NRO40_RS00435	COG2755	lipolytic protein G-D-S-L family
NRO40_RS00440	COG3467	pyridoxamine 5'-phosphate
NRO40_RS00480	COG0488	(ABC) transporter
NRO40_RS00495	COG1175	transmembrane transport
NRO40_RS00500	COG0395	ABC-type sugar transport system, permease component
NRO40_RS00545	COG0515	serine threonine protein kinase
NRO40_RS00555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRO40_RS00560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRO40_RS00580	COG4251	negative regulation of phosphorylation
NRO40_RS00585	COG0784	Response regulator, receiver
NRO40_RS00595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRO40_RS00610	COG3118	belongs to the thioredoxin family
NRO40_RS00635	COG0702	epimerase
NRO40_RS00640	COG3321	synthase
NRO40_RS00640	COG0604	alcohol dehydrogenase
NRO40_RS00655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NRO40_RS00660	COG1819	glycosyl
NRO40_RS00665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRO40_RS00675	COG1335	isochorismatase
NRO40_RS00715	COG3708	Transcriptional regulator
NRO40_RS00715	COG2207	Transcriptional regulator
NRO40_RS00730	COG1846	Transcriptional regulator
NRO40_RS00735	COG1595	DNA-templated transcription, initiation
NRO40_RS00740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRO40_RS00750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRO40_RS00805	COG1902	pentaerythritol trinitrate reductase activity
NRO40_RS00845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NRO40_RS00860	COG4977	sequence-specific DNA binding
NRO40_RS00895	COG3655	Transcriptional regulator
NRO40_RS00905	COG3866	Pectate lyase
NRO40_RS00910	COG0596	Alpha beta hydrolase
NRO40_RS00915	COG0586	Pfam SNARE associated Golgi protein
NRO40_RS00930	COG3795	YCII-related domain
NRO40_RS00935	COG4941	Belongs to the sigma-70 factor family
NRO40_RS00965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRO40_RS01070	COG1309	transcriptional regulator
NRO40_RS01085	COG2890	protein-(glutamine-N5) methyltransferase activity
NRO40_RS01105	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS01130	COG2271	Major facilitator Superfamily
NRO40_RS01135	COG0515	serine threonine protein kinase
NRO40_RS01145	COG1132	(ABC) transporter
NRO40_RS01150	COG1132	(ABC) transporter
NRO40_RS01155	COG2197	response regulator
NRO40_RS01165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NRO40_RS01180	COG0725	ABC transporter, periplasmic molybdate-binding protein
NRO40_RS01185	COG3842	ATPase activity
NRO40_RS01195	COG0596	Alpha beta hydrolase
NRO40_RS01200	COG2770	Histidine kinase
NRO40_RS01200	COG2208	phosphoserine phosphatase activity
NRO40_RS01215	COG0009	L-threonylcarbamoyladenylate synthase
NRO40_RS01305	COG0277	FAD linked oxidase domain protein
NRO40_RS01345	COG0463	Glycosyl transferase, family 2
NRO40_RS01400	COG2366	antibiotic biosynthetic process
NRO40_RS01405	COG0387	Pfam Sodium calcium exchanger
NRO40_RS01425	COG0515	serine threonine protein kinase
NRO40_RS01435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRO40_RS01435	COG0723	plastoquinol--plastocyanin reductase activity
NRO40_RS01455	COG3386	PFAM SMP-30 Gluconolaconase
NRO40_RS01460	COG1414	Transcriptional regulator
NRO40_RS01490	COG4214	carbohydrate transport
NRO40_RS01505	COG1472	Belongs to the glycosyl hydrolase 3 family
NRO40_RS01515	COG4209	transmembrane transport
NRO40_RS01520	COG0395	ABC-type sugar transport system, permease component
NRO40_RS01570	COG1796	DNA polymerase
NRO40_RS01570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NRO40_RS01585	COG0435	Glutathione S-transferase
NRO40_RS01595	COG1295	ribonuclease BN
NRO40_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS01605	COG1716	ATPase activity
NRO40_RS01605	COG0842	Transport permease protein
NRO40_RS01605	COG1131	(ABC) transporter
NRO40_RS01640	COG1175	transmembrane transport
NRO40_RS01645	COG1653	transport
NRO40_RS01670	COG1404	Belongs to the peptidase S8 family
NRO40_RS01690	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NRO40_RS01695	COG2376	Dihydroxyacetone kinase
NRO40_RS01700	COG1461	Dihydroxyacetone kinase
NRO40_RS01710	COG0310	cobalt ion transport
NRO40_RS01715	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NRO40_RS01725	COG1122	ATPase activity
NRO40_RS01730	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRO40_RS01730	COG1902	pentaerythritol trinitrate reductase activity
NRO40_RS01750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRO40_RS01775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRO40_RS01780	COG0765	amino acid transport
NRO40_RS01805	COG0753	catalase activity
NRO40_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS01825	COG4977	sequence-specific DNA binding
NRO40_RS01845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NRO40_RS01860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NRO40_RS01865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRO40_RS01870	COG2192	nodulation
NRO40_RS01880	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS01885	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NRO40_RS01890	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NRO40_RS01890	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NRO40_RS01940	COG3290	protein histidine kinase activity
NRO40_RS02005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRO40_RS02005	COG0574	Belongs to the PEP-utilizing enzyme family
NRO40_RS02020	COG1937	Protein conserved in bacteria
NRO40_RS02030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRO40_RS02030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRO40_RS02035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRO40_RS02065	COG0477	Major facilitator Superfamily
NRO40_RS02070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NRO40_RS02080	COG2124	cytochrome p450
NRO40_RS02120	COG3962	Belongs to the TPP enzyme family
NRO40_RS02125	COG3718	enzyme involved in inositol metabolism
NRO40_RS02140	COG0673	inositol 2-dehydrogenase activity
NRO40_RS02165	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NRO40_RS02170	COG2755	lipolytic protein G-D-S-L family
NRO40_RS02185	COG3401	FG-GAP repeat protein
NRO40_RS02240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NRO40_RS02290	COG1472	Belongs to the glycosyl hydrolase 3 family
NRO40_RS02360	COG0395	ABC-type sugar transport system, permease component
NRO40_RS02365	COG1175	transmembrane transport
NRO40_RS02410	COG2205	protein histidine kinase activity
NRO40_RS02410	COG3850	Histidine kinase
NRO40_RS02410	COG4999	Histidine kinase
NRO40_RS02410	COG3437	response regulator, receiver
NRO40_RS02420	COG1191	sigma factor activity
NRO40_RS02440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NRO40_RS02495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRO40_RS02500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRO40_RS02505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NRO40_RS02510	COG0598	Magnesium transport protein CorA
NRO40_RS02530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRO40_RS02565	COG1231	oxidoreductase activity
NRO40_RS02600	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS02610	COG1940	carbohydrate kinase activity
NRO40_RS02625	COG0513	Belongs to the DEAD box helicase family
NRO40_RS02630	COG1609	Transcriptional regulator
NRO40_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS02640	COG3347	Dehydrogenase
NRO40_RS02645	COG1070	Carbohydrate kinase
NRO40_RS02650	COG0247	lactate metabolic process
NRO40_RS02655	COG1139	Iron-sulfur cluster binding protein
NRO40_RS02660	COG1556	Lactate utilization protein
NRO40_RS02665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NRO40_RS02680	COG1063	alcohol dehydrogenase
NRO40_RS02690	COG3265	gluconokinase activity
NRO40_RS02700	COG0589	response to stress
NRO40_RS02715	COG2208	phosphoserine phosphatase activity
NRO40_RS02715	COG2770	Histidine kinase
NRO40_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS02750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NRO40_RS02755	COG0463	Glycosyl transferase, family 2
NRO40_RS02770	COG0633	Ferredoxin
NRO40_RS02770	COG3217	Mosc domain protein beta barrel domain protein
NRO40_RS02775	COG0464	growth
NRO40_RS02785	COG1349	DNA-binding transcription factor activity
NRO40_RS02815	COG1940	carbohydrate kinase activity
NRO40_RS02840	COG0445	tRNA wobble uridine modification
NRO40_RS02855	COG1470	cell adhesion involved in biofilm formation
NRO40_RS02875	COG0515	serine threonine protein kinase
NRO40_RS02885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NRO40_RS02905	COG0204	Acyl-transferase
NRO40_RS02925	COG0584	glycerophosphoryl diester phosphodiesterase
NRO40_RS02930	COG0542	response to heat
NRO40_RS02945	COG0671	phosphoesterase, PA-phosphatase related
NRO40_RS02950	COG1309	transcriptional regulator
NRO40_RS02965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRO40_RS02970	COG2971	BadF BadG BcrA BcrD
NRO40_RS02980	COG2706	6-phosphogluconolactonase activity
NRO40_RS02990	COG4948	Mandelate Racemase Muconate Lactonizing
NRO40_RS03000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRO40_RS03015	COG0395	ABC-type sugar transport system, permease component
NRO40_RS03020	COG1175	transmembrane transport
NRO40_RS03040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRO40_RS03045	COG3693	PFAM glycoside hydrolase, family 10
NRO40_RS03060	COG0673	inositol 2-dehydrogenase activity
NRO40_RS03070	COG5520	Belongs to the glycosyl hydrolase 30 family
NRO40_RS03075	COG0395	ABC-type sugar transport system, permease component
NRO40_RS03080	COG1175	transmembrane transport
NRO40_RS03095	COG1472	Belongs to the glycosyl hydrolase 3 family
NRO40_RS03100	COG3507	Belongs to the glycosyl hydrolase 43 family
NRO40_RS03115	COG0432	Pfam Uncharacterised protein family UPF0047
NRO40_RS03120	COG2072	flavoprotein involved in K transport
NRO40_RS03130	COG1132	(ABC) transporter
NRO40_RS03140	COG0673	inositol 2-dehydrogenase activity
NRO40_RS03155	COG1132	(ABC) transporter
NRO40_RS03170	COG1946	Acyl-CoA thioesterase
NRO40_RS03180	COG0386	Belongs to the glutathione peroxidase family
NRO40_RS03195	COG0577	efflux transmembrane transporter activity
NRO40_RS03195	COG1136	(ABC) transporter
NRO40_RS03205	COG1653	transport
NRO40_RS03210	COG0366	Alpha amylase catalytic
NRO40_RS03215	COG1653	transport
NRO40_RS03220	COG1175	transmembrane transport
NRO40_RS03225	COG0395	ABC-type sugar transport system, permease component
NRO40_RS03230	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS03240	COG0242	peptide deformylase activity
NRO40_RS03250	COG3442	glutamine amidotransferase
NRO40_RS03255	COG0205	6-phosphofructokinase activity
NRO40_RS03280	COG0829	nickel cation binding
NRO40_RS03285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NRO40_RS03290	COG0830	nickel cation binding
NRO40_RS03295	COG0804	urea catabolic process
NRO40_RS03300	COG0832	Belongs to the urease beta subunit family
NRO40_RS03305	COG0831	urea catabolic process
NRO40_RS03310	COG1309	transcriptional regulator
NRO40_RS03325	COG0740	serine-type endopeptidase activity
NRO40_RS03350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NRO40_RS03355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRO40_RS03360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NRO40_RS03370	COG2226	methyltransferase
NRO40_RS03405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NRO40_RS03420	COG1940	carbohydrate kinase activity
NRO40_RS03425	COG2188	Transcriptional regulator
NRO40_RS03450	COG0346	lactoylglutathione lyase activity
NRO40_RS03475	COG1522	sequence-specific DNA binding
NRO40_RS03480	COG0419	ATPase involved in DNA repair
NRO40_RS03485	COG0420	3'-5' exonuclease activity
NRO40_RS03490	COG1739	Uncharacterized protein family UPF0029
NRO40_RS03500	COG1832	CoA-binding protein
NRO40_RS03505	COG4214	carbohydrate transport
NRO40_RS03515	COG4213	ABC transporter substrate-binding protein
NRO40_RS03525	COG0110	maltose O-acetyltransferase activity
NRO40_RS03560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRO40_RS03570	COG1968	undecaprenyl-diphosphatase activity
NRO40_RS03585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NRO40_RS03595	COG2318	DinB family
NRO40_RS03605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NRO40_RS03715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRO40_RS03715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NRO40_RS03725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NRO40_RS03745	COG1716	ATPase activity
NRO40_RS03765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NRO40_RS03795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRO40_RS03805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRO40_RS03820	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NRO40_RS03870	COG2814	Major facilitator Superfamily
NRO40_RS03875	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NRO40_RS03880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NRO40_RS03885	COG1984	allophanate hydrolase subunit 2
NRO40_RS03920	COG2364	Membrane
NRO40_RS03930	COG2270	Major facilitator Superfamily
NRO40_RS03945	COG1216	Glycosyl transferase, family 2
NRO40_RS03970	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS04000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NRO40_RS04005	COG0140	phosphoribosyl-ATP diphosphatase activity
NRO40_RS04010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NRO40_RS04015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRO40_RS04015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NRO40_RS04020	COG3201	nicotinamide mononucleotide transporter
NRO40_RS04040	COG1595	DNA-templated transcription, initiation
NRO40_RS04045	COG1090	epimerase
NRO40_RS04050	COG1846	Transcriptional regulator
NRO40_RS04050	COG1940	carbohydrate kinase activity
NRO40_RS04055	COG0738	Major facilitator superfamily
NRO40_RS04060	COG2233	PERMEase
NRO40_RS04075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NRO40_RS04085	COG0531	amino acid
NRO40_RS04095	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS04100	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS04105	COG2172	sigma factor antagonist activity
NRO40_RS04115	COG2770	Histidine kinase
NRO40_RS04115	COG2208	phosphoserine phosphatase activity
NRO40_RS04125	COG1191	sigma factor activity
NRO40_RS04135	COG2390	Transcriptional regulator
NRO40_RS04140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NRO40_RS04150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NRO40_RS04185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NRO40_RS04200	COG0194	GDP metabolic process
NRO40_RS04210	COG0284	orotidine-5'-phosphate decarboxylase activity
NRO40_RS04215	COG0167	dihydroorotate dehydrogenase activity
NRO40_RS04220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRO40_RS04225	COG0505	Belongs to the CarA family
NRO40_RS04235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRO40_RS04240	COG0540	Belongs to the ATCase OTCase family
NRO40_RS04245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NRO40_RS04255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NRO40_RS04260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NRO40_RS04265	COG0006	proline dipeptidase activity
NRO40_RS04275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NRO40_RS04280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NRO40_RS04285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NRO40_RS04290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NRO40_RS04295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NRO40_RS04305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NRO40_RS04310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NRO40_RS04330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NRO40_RS04350	COG0124	histidyl-tRNA synthetase
NRO40_RS04360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NRO40_RS04365	COG1196	nuclear chromosome segregation
NRO40_RS04370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRO40_RS04375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NRO40_RS04380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRO40_RS04385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRO40_RS04395	COG2255	four-way junction helicase activity
NRO40_RS04400	COG0632	four-way junction helicase activity
NRO40_RS04405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NRO40_RS04410	COG0217	transcriptional regulatory protein
NRO40_RS04415	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NRO40_RS04420	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NRO40_RS04430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRO40_RS04435	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS04440	COG1560	Kdo2-lipid A biosynthetic process
NRO40_RS04445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NRO40_RS04465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NRO40_RS04480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NRO40_RS04540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NRO40_RS04585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRO40_RS04585	COG1648	precorrin-2 dehydrogenase activity
NRO40_RS04590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NRO40_RS04605	COG1464	Belongs to the NlpA lipoprotein family
NRO40_RS04610	COG2011	ABC-type metal ion transport system permease component
NRO40_RS04615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NRO40_RS04640	COG0584	glycerophosphoryl diester phosphodiesterase
NRO40_RS04645	COG0204	Acyl-transferase
NRO40_RS04645	COG0318	PFAM AMP-dependent synthetase and ligase
NRO40_RS04650	COG0477	Major facilitator Superfamily
NRO40_RS04660	COG0165	Argininosuccinate lyase
NRO40_RS04665	COG0137	argininosuccinate synthase activity
NRO40_RS04675	COG1438	arginine binding
NRO40_RS04680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRO40_RS04685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NRO40_RS04690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NRO40_RS04695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NRO40_RS04725	COG2813	Specifically methylates the guanine in position
NRO40_RS04745	COG1649	PFAM Uncharacterised BCR, COG1649
NRO40_RS04755	COG1051	belongs to the nudix hydrolase family
NRO40_RS04770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRO40_RS04770	COG0072	phenylalanine-tRNA ligase activity
NRO40_RS04775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NRO40_RS04780	COG5002	protein histidine kinase activity
NRO40_RS04785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRO40_RS04790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NRO40_RS04795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NRO40_RS04800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NRO40_RS04840	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS04845	COG0174	glutamine synthetase
NRO40_RS04855	COG1113	amino acid transport
NRO40_RS04860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NRO40_RS04885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NRO40_RS04915	COG0805	protein transport
NRO40_RS04920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRO40_RS04950	COG0545	Peptidyl-prolyl cis-trans isomerase
NRO40_RS04955	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NRO40_RS04965	COG1609	Transcriptional regulator
NRO40_RS04970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NRO40_RS04975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NRO40_RS04990	COG4122	O-methyltransferase activity
NRO40_RS04995	COG1222	aaa ATPase
NRO40_RS05015	COG0517	IMP dehydrogenase activity
NRO40_RS05015	COG1994	Peptidase M50
NRO40_RS05025	COG2197	response regulator
NRO40_RS05030	COG0747	negative chemotaxis
NRO40_RS05045	COG0646	methionine synthase
NRO40_RS05045	COG1410	methionine synthase
NRO40_RS05050	COG1414	Transcriptional regulator
NRO40_RS05055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NRO40_RS05060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NRO40_RS05065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRO40_RS05075	COG0215	cysteine-tRNA ligase activity
NRO40_RS05095	COG0598	Magnesium transport protein CorA
NRO40_RS05105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRO40_RS05110	COG0667	Aldo Keto reductase
NRO40_RS05145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRO40_RS05170	COG1501	Belongs to the glycosyl hydrolase 31 family
NRO40_RS05175	COG0564	pseudouridine synthase activity
NRO40_RS05190	COG1113	amino acid transport
NRO40_RS05195	COG2186	Transcriptional regulator
NRO40_RS05200	COG3265	gluconokinase activity
NRO40_RS05225	COG1131	(ABC) transporter
NRO40_RS05245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NRO40_RS05250	COG2149	membrane
NRO40_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS05295	COG3876	Protein conserved in bacteria
NRO40_RS05310	COG0789	Transcriptional regulator
NRO40_RS05330	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS05340	COG0477	Major facilitator Superfamily
NRO40_RS05370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NRO40_RS05375	COG2188	Transcriptional regulator
NRO40_RS05395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRO40_RS05405	COG0515	serine threonine protein kinase
NRO40_RS05405	COG2815	serine threonine protein kinase
NRO40_RS05410	COG2755	lipolytic protein G-D-S-L family
NRO40_RS05420	COG1725	Transcriptional regulator
NRO40_RS05455	COG4565	transcriptional regulatory protein
NRO40_RS05480	COG0587	DNA-directed DNA polymerase activity
NRO40_RS05500	COG1799	cell septum assembly
NRO40_RS05505	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS05510	COG0477	Major facilitator Superfamily
NRO40_RS05515	COG0671	phosphoesterase, PA-phosphatase related
NRO40_RS05535	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS05555	COG1129	ABC transporter
NRO40_RS05580	COG1160	GTP binding
NRO40_RS05590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NRO40_RS05615	COG3541	Predicted nucleotidyltransferase
NRO40_RS05625	COG0494	nUDIX hydrolase
NRO40_RS05630	COG1187	pseudouridine synthase activity
NRO40_RS05635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NRO40_RS05640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NRO40_RS05655	COG0686	Belongs to the AlaDH PNT family
NRO40_RS05665	COG0494	nUDIX hydrolase
NRO40_RS05670	COG0504	CTP synthase activity
NRO40_RS05675	COG3387	PFAM Glycoside hydrolase 15-related
NRO40_RS05685	COG0297	glycogen (starch) synthase activity
NRO40_RS05695	COG0497	DNA recombination
NRO40_RS05700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NRO40_RS05715	COG1120	ATPase activity
NRO40_RS05720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRO40_RS05725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRO40_RS05730	COG0647	UMP catabolic process
NRO40_RS05765	COG2094	Belongs to the DNA glycosylase MPG family
NRO40_RS05775	COG1881	PFAM PEBP family protein
NRO40_RS05800	COG1119	ATPase activity
NRO40_RS05810	COG2197	response regulator
NRO40_RS05815	COG4585	Histidine kinase
NRO40_RS05825	COG1131	(ABC) transporter
NRO40_RS05825	COG1716	ATPase activity
NRO40_RS05825	COG0842	Transport permease protein
NRO40_RS05830	COG0560	Phosphoserine phosphatase
NRO40_RS05830	COG3830	Belongs to the UPF0237 family
NRO40_RS05855	COG2186	Transcriptional regulator
NRO40_RS05870	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS05890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NRO40_RS05910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NRO40_RS05915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRO40_RS05965	COG3387	PFAM Glycoside hydrolase 15-related
NRO40_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS05975	COG1024	Enoyl-CoA hydratase
NRO40_RS05985	COG0488	(ABC) transporter
NRO40_RS06010	COG0235	Class ii aldolase
NRO40_RS06025	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NRO40_RS06030	COG1492	cobalamin metabolic process
NRO40_RS06040	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NRO40_RS06045	COG1797	cobyrinic acid a,c-diamide synthase activity
NRO40_RS06080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NRO40_RS06095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRO40_RS06105	COG5285	phytanoyl-CoA dioxygenase
NRO40_RS06110	COG1902	pentaerythritol trinitrate reductase activity
NRO40_RS06115	COG1846	Transcriptional regulator
NRO40_RS06125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NRO40_RS06135	COG0346	lactoylglutathione lyase activity
NRO40_RS06145	COG1414	Transcriptional regulator
NRO40_RS06160	COG4585	Histidine kinase
NRO40_RS06180	COG0501	Belongs to the peptidase M48B family
NRO40_RS06190	COG3866	Pectate lyase
NRO40_RS06195	COG2755	lipolytic protein G-D-S-L family
NRO40_RS06200	COG1653	transport
NRO40_RS06205	COG3866	Pectate lyase
NRO40_RS06210	COG3507	Belongs to the glycosyl hydrolase 43 family
NRO40_RS06225	COG0395	ABC-type sugar transport system, permease component
NRO40_RS06230	COG1175	transmembrane transport
NRO40_RS06245	COG1802	Transcriptional regulator
NRO40_RS06255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRO40_RS06260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRO40_RS06315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRO40_RS06325	COG2171	N-acyltransferase activity
NRO40_RS06340	COG0822	iron-sulfur transferase activity
NRO40_RS06345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRO40_RS06350	COG0396	ATPase activity
NRO40_RS06360	COG0719	Fe-S assembly protein
NRO40_RS06375	COG1131	(ABC) transporter
NRO40_RS06385	COG1612	heme a metabolic process
NRO40_RS06395	COG0109	protoheme IX farnesyltransferase activity
NRO40_RS06405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NRO40_RS06420	COG0363	glucosamine-6-phosphate deaminase activity
NRO40_RS06435	COG0166	Belongs to the GPI family
NRO40_RS06445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NRO40_RS06450	COG0149	triose-phosphate isomerase activity
NRO40_RS06455	COG0126	phosphoglycerate kinase activity
NRO40_RS06460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NRO40_RS06465	COG1481	regulation of sporulation
NRO40_RS06475	COG1660	Displays ATPase and GTPase activities
NRO40_RS06480	COG0322	excinuclease ABC activity
NRO40_RS06505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRO40_RS06540	COG0556	nucleotide-excision repair
NRO40_RS06555	COG2226	methyltransferase
NRO40_RS06560	COG2313	pseudouridylate synthase activity
NRO40_RS06580	COG0436	Aminotransferase
NRO40_RS06610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRO40_RS06625	COG0237	dephospho-CoA kinase activity
NRO40_RS06640	COG0539	negative regulation of cytoplasmic translation
NRO40_RS06645	COG2226	methyltransferase
NRO40_RS06650	COG1643	Atp-dependent helicase
NRO40_RS06675	COG2050	protein possibly involved in aromatic compounds catabolism
NRO40_RS06725	COG0737	Belongs to the 5'-nucleotidase family
NRO40_RS06730	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NRO40_RS06740	COG1605	Chorismate mutase
NRO40_RS06740	COG0287	Prephenate dehydrogenase
NRO40_RS06775	COG0069	glutamate synthase activity
NRO40_RS06775	COG0067	glutamate synthase
NRO40_RS06775	COG0070	glutamate synthase
NRO40_RS06785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NRO40_RS06795	COG0159	tryptophan synthase activity
NRO40_RS06800	COG0133	tryptophan synthase activity
NRO40_RS06810	COG0134	indole-3-glycerol-phosphate synthase activity
NRO40_RS06835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NRO40_RS06845	COG0107	imidazoleglycerol-phosphate synthase activity
NRO40_RS06850	COG0251	oxidation-reduction process
NRO40_RS06855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NRO40_RS06860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NRO40_RS06870	COG0131	Imidazoleglycerol-phosphate dehydratase
NRO40_RS06875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRO40_RS06880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NRO40_RS06900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NRO40_RS06920	COG1432	Conserved Protein
NRO40_RS06930	COG0587	DNA-directed DNA polymerase activity
NRO40_RS06990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NRO40_RS07000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NRO40_RS07005	COG3599	regulation of cell shape
NRO40_RS07015	COG1799	cell septum assembly
NRO40_RS07020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NRO40_RS07025	COG1496	oxidoreductase activity
NRO40_RS07035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NRO40_RS07040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NRO40_RS07050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NRO40_RS07055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NRO40_RS07065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NRO40_RS07070	COG0768	penicillin binding
NRO40_RS07080	COG0275	rRNA processing
NRO40_RS07090	COG0714	Associated with various cellular activities
NRO40_RS07115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NRO40_RS07130	COG1511	domain protein
NRO40_RS07135	COG1309	transcriptional regulator
NRO40_RS07155	COG0352	thiamine-phosphate diphosphorylase activity
NRO40_RS07165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRO40_RS07170	COG2022	thiamine diphosphate biosynthetic process
NRO40_RS07170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRO40_RS07180	COG2022	thiamine diphosphate biosynthetic process
NRO40_RS07185	COG0515	serine threonine protein kinase
NRO40_RS07185	COG2815	serine threonine protein kinase
NRO40_RS07190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NRO40_RS07200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NRO40_RS07205	COG2193	ferroxidase activity
NRO40_RS07210	COG0243	molybdopterin cofactor binding
NRO40_RS07215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NRO40_RS07225	COG2197	response regulator
NRO40_RS07230	COG4585	Histidine kinase
NRO40_RS07255	COG1940	carbohydrate kinase activity
NRO40_RS07265	COG0003	Pfam Anion-transporting ATPase
NRO40_RS07285	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS07300	COG3883	PFAM NLP P60 protein
NRO40_RS07300	COG0791	NLP P60 protein
NRO40_RS07330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRO40_RS07335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NRO40_RS07340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRO40_RS07345	COG0723	plastoquinol--plastocyanin reductase activity
NRO40_RS07350	COG2010	Cytochrome c
NRO40_RS07355	COG1845	cytochrome c oxidase, subunit III
NRO40_RS07365	COG1376	ErfK ybiS ycfS ynhG family protein
NRO40_RS07375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NRO40_RS07380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NRO40_RS07390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRO40_RS07410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NRO40_RS07415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NRO40_RS07420	COG2197	response regulator
NRO40_RS07425	COG4585	Histidine kinase
NRO40_RS07450	COG1132	(ABC) transporter
NRO40_RS07455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRO40_RS07470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NRO40_RS07485	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NRO40_RS07515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NRO40_RS07520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRO40_RS07525	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRO40_RS07535	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NRO40_RS07575	COG0321	lipoyl(octanoyl) transferase activity
NRO40_RS07580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NRO40_RS07675	COG1309	transcriptional regulator
NRO40_RS07700	COG0366	Alpha amylase catalytic
NRO40_RS07705	COG3833	ABC-type maltose transport systems, permease component
NRO40_RS07710	COG1175	transmembrane transport
NRO40_RS07715	COG1653	transport
NRO40_RS07720	COG0366	Alpha amylase catalytic
NRO40_RS07725	COG1609	Transcriptional regulator
NRO40_RS07735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NRO40_RS07750	COG0174	glutamine synthetase
NRO40_RS07785	COG0477	Major facilitator Superfamily
NRO40_RS07790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NRO40_RS07810	COG1994	Peptidase M50
NRO40_RS07875	COG1834	amidinotransferase
NRO40_RS07890	COG2814	Major facilitator Superfamily
NRO40_RS07900	COG3540	Alkaline phosphatase
NRO40_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS07940	COG0557	exoribonuclease II activity
NRO40_RS07945	COG3022	response to hydroperoxide
NRO40_RS07950	COG0800	Aldolase
NRO40_RS07965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NRO40_RS07975	COG2030	dehydratase
NRO40_RS08020	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS08025	COG1309	transcriptional regulator
NRO40_RS08030	COG1657	PFAM Prenyltransferase squalene oxidase
NRO40_RS08045	COG3845	ABC transporter
NRO40_RS08060	COG4122	O-methyltransferase activity
NRO40_RS08180	COG2154	pterin-4-alpha-carbinolamine dehydratase
NRO40_RS08205	COG2188	Transcriptional regulator
NRO40_RS08540	COG1358	cellular component organization or biogenesis
NRO40_RS08585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NRO40_RS08590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRO40_RS08600	COG0477	Major facilitator Superfamily
NRO40_RS08605	COG1309	transcriptional regulator
NRO40_RS08620	COG4585	Histidine kinase
NRO40_RS08625	COG2197	response regulator
NRO40_RS08640	COG0667	Aldo Keto reductase
NRO40_RS08645	COG0789	Transcriptional regulator
NRO40_RS08675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRO40_RS08680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NRO40_RS08685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRO40_RS08730	COG1764	response to oxidative stress
NRO40_RS08735	COG2130	NADP-dependent
NRO40_RS08755	COG1077	Cell shape determining protein MreB Mrl
NRO40_RS08760	COG0318	PFAM AMP-dependent synthetase and ligase
NRO40_RS08765	COG0825	malonyl-CoA metabolic process
NRO40_RS08765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NRO40_RS08770	COG1846	Transcriptional regulator
NRO40_RS08775	COG1764	response to oxidative stress
NRO40_RS08790	COG3903	Transcriptional regulator
NRO40_RS08790	COG3629	intracellular signal transduction
NRO40_RS08810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRO40_RS08825	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NRO40_RS08845	COG3903	Transcriptional regulator
NRO40_RS08845	COG3629	intracellular signal transduction
NRO40_RS08870	COG1070	Carbohydrate kinase
NRO40_RS08890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRO40_RS08895	COG0358	DNA primase activity
NRO40_RS08905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NRO40_RS08940	COG0243	molybdopterin cofactor binding
NRO40_RS08945	COG2949	membrane
NRO40_RS08980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRO40_RS08985	COG2146	nitrite reductase [NAD(P)H] activity
NRO40_RS08985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRO40_RS08990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRO40_RS08990	COG2146	nitrite reductase [NAD(P)H] activity
NRO40_RS09010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NRO40_RS09010	COG0574	Belongs to the PEP-utilizing enzyme family
NRO40_RS09025	COG0423	glycine-tRNA ligase activity
NRO40_RS09030	COG3443	Belongs to the bacterial solute-binding protein 9 family
NRO40_RS09030	COG0803	Belongs to the bacterial solute-binding protein 9 family
NRO40_RS09035	COG1121	(ABC) transporter
NRO40_RS09040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NRO40_RS09050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRO40_RS09055	COG1381	Involved in DNA repair and RecF pathway recombination
NRO40_RS09070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRO40_RS09085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NRO40_RS09095	COG2315	Protein conserved in bacteria
NRO40_RS09105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NRO40_RS09115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRO40_RS09120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRO40_RS09125	COG1234	tRNA 3'-trailer cleavage
NRO40_RS09130	COG0537	adenosine 5'-monophosphoramidase activity
NRO40_RS09145	COG0484	heat shock protein binding
NRO40_RS09150	COG1420	regulation of RNA biosynthetic process
NRO40_RS09175	COG0481	GTPase activity
NRO40_RS09180	COG0268	Binds directly to 16S ribosomal RNA
NRO40_RS09200	COG1555	photosystem II stabilization
NRO40_RS09200	COG1596	polysaccharide export
NRO40_RS09205	COG1307	EDD domain protein, DegV family
NRO40_RS09215	COG0495	leucyl-tRNA aminoacylation
NRO40_RS09225	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NRO40_RS09255	COG0588	phosphoglycerate mutase activity
NRO40_RS09260	COG0799	negative regulation of ribosome biogenesis
NRO40_RS09270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NRO40_RS09280	COG0501	Belongs to the peptidase M48B family
NRO40_RS09295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NRO40_RS09305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NRO40_RS09320	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS09325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NRO40_RS09330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NRO40_RS09335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NRO40_RS09340	COG1216	Glycosyl transferase, family 2
NRO40_RS09350	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS09395	COG0673	inositol 2-dehydrogenase activity
NRO40_RS09405	COG1530	ribonuclease E activity
NRO40_RS09425	COG0772	Belongs to the SEDS family
NRO40_RS09430	COG0768	penicillin binding
NRO40_RS09445	COG1077	Cell shape determining protein MreB Mrl
NRO40_RS09450	COG0105	UTP biosynthetic process
NRO40_RS09460	COG0285	dihydrofolate synthase activity
NRO40_RS09465	COG0525	valine-tRNA ligase activity
NRO40_RS09475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NRO40_RS09480	COG0740	serine-type endopeptidase activity
NRO40_RS09485	COG0740	serine-type endopeptidase activity
NRO40_RS09490	COG0544	peptidyl-prolyl cis-trans isomerase activity
NRO40_RS09510	COG3594	Acyltransferase
NRO40_RS09535	COG1113	amino acid transport
NRO40_RS09545	COG1113	amino acid transport
NRO40_RS09550	COG1113	amino acid transport
NRO40_RS09555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NRO40_RS09560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NRO40_RS09580	COG0494	nUDIX hydrolase
NRO40_RS09600	COG0697	spore germination
NRO40_RS09605	COG1846	Transcriptional regulator
NRO40_RS09625	COG3291	Pkd domain containing protein
NRO40_RS09625	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NRO40_RS09635	COG0668	transmembrane transport
NRO40_RS09655	COG1486	melibiose metabolic process
NRO40_RS09670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRO40_RS09700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NRO40_RS09730	COG0629	single-stranded DNA binding
NRO40_RS09740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NRO40_RS09880	COG2197	response regulator
NRO40_RS09885	COG4585	Histidine kinase
NRO40_RS09935	COG0028	Belongs to the TPP enzyme family
NRO40_RS09945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NRO40_RS09950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRO40_RS09975	COG0318	PFAM AMP-dependent synthetase and ligase
NRO40_RS09980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRO40_RS09985	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS09995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NRO40_RS10040	COG1131	(ABC) transporter
NRO40_RS10070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NRO40_RS10085	COG0673	inositol 2-dehydrogenase activity
NRO40_RS10090	COG1609	Transcriptional regulator
NRO40_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS10130	COG1472	Belongs to the glycosyl hydrolase 3 family
NRO40_RS10150	COG1132	(ABC) transporter
NRO40_RS10155	COG2356	endonuclease I
NRO40_RS10160	COG0028	Belongs to the TPP enzyme family
NRO40_RS10200	COG1946	Acyl-CoA thioesterase
NRO40_RS10225	COG1309	transcriptional regulator
NRO40_RS10230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRO40_RS10245	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS10255	COG2375	cellular response to nickel ion
NRO40_RS10260	COG0076	glutamate decarboxylase activity
NRO40_RS10265	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NRO40_RS10290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRO40_RS10310	COG4977	sequence-specific DNA binding
NRO40_RS10315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NRO40_RS10375	COG5297	Belongs to the glycosyl hydrolase family 6
NRO40_RS10375	COG4733	cellulase activity
NRO40_RS10385	COG5297	Belongs to the glycosyl hydrolase family 6
NRO40_RS10410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NRO40_RS10450	COG0395	ABC-type sugar transport system, permease component
NRO40_RS10480	COG0745	RESPONSE REGULATOR receiver
NRO40_RS10490	COG2340	Cysteine-rich secretory protein family
NRO40_RS10510	COG0406	alpha-ribazole phosphatase activity
NRO40_RS10550	COG3300	MHYT domain
NRO40_RS10550	COG5001	Diguanylate cyclase
NRO40_RS10560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRO40_RS10580	COG1126	abc transporter atp-binding protein
NRO40_RS10660	COG0673	inositol 2-dehydrogenase activity
NRO40_RS10665	COG4702	Belongs to the UPF0303 family
NRO40_RS10710	COG2733	membrane
NRO40_RS10730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRO40_RS10770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NRO40_RS10780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NRO40_RS10785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NRO40_RS10790	COG1263	PTS System
NRO40_RS10795	COG1263	PTS System
NRO40_RS10805	COG1234	tRNA 3'-trailer cleavage
NRO40_RS10835	COG1113	amino acid transport
NRO40_RS10845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NRO40_RS10855	COG1335	isochorismatase
NRO40_RS10895	COG0277	FAD linked oxidase domain protein
NRO40_RS10905	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NRO40_RS10950	COG2186	Transcriptional regulator
NRO40_RS10980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRO40_RS10995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NRO40_RS11005	COG1678	Uncharacterized ACR, COG1678
NRO40_RS11010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRO40_RS11015	COG0776	regulation of translation
NRO40_RS11025	COG3973	AAA domain
NRO40_RS11055	COG0583	DNA-binding transcription factor activity
NRO40_RS11075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NRO40_RS11080	COG0793	Belongs to the peptidase S41A family
NRO40_RS11080	COG3409	Peptidoglycan-binding domain 1 protein
NRO40_RS11090	COG2884	Cell division ATP-binding protein ftsE
NRO40_RS11105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NRO40_RS11115	COG0515	serine threonine protein kinase
NRO40_RS11120	COG0515	serine threonine protein kinase
NRO40_RS11140	COG1175	transmembrane transport
NRO40_RS11145	COG0395	ABC-type sugar transport system, permease component
NRO40_RS11155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NRO40_RS11160	COG1215	transferase activity, transferring glycosyl groups
NRO40_RS11165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NRO40_RS11200	COG1309	transcriptional regulator
NRO40_RS11210	COG1134	teichoic acid transport
NRO40_RS11220	COG2902	Dehydrogenase
NRO40_RS11240	COG0653	protein targeting
NRO40_RS11250	COG3214	Protein conserved in bacteria
NRO40_RS11255	COG2197	response regulator
NRO40_RS11260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NRO40_RS11270	COG0823	Involved in the tonB-independent uptake of proteins
NRO40_RS11275	COG5002	protein histidine kinase activity
NRO40_RS11275	COG5000	phosphorelay sensor kinase activity
NRO40_RS11280	COG0745	RESPONSE REGULATOR receiver
NRO40_RS11285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NRO40_RS11305	COG0714	Associated with various cellular activities
NRO40_RS11345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NRO40_RS11355	COG1482	cell wall glycoprotein biosynthetic process
NRO40_RS11365	COG2835	tetraacyldisaccharide 4'-kinase activity
NRO40_RS11375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRO40_RS11410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NRO40_RS11415	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NRO40_RS11415	COG0778	Nitroreductase
NRO40_RS11440	COG1316	TRANSCRIPTIONal
NRO40_RS11445	COG1316	TRANSCRIPTIONal
NRO40_RS11450	COG1316	TRANSCRIPTIONal
NRO40_RS11455	COG1316	TRANSCRIPTIONal
NRO40_RS11570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NRO40_RS11580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NRO40_RS11595	COG2205	protein histidine kinase activity
NRO40_RS11600	COG0745	RESPONSE REGULATOR receiver
NRO40_RS11605	COG3104	oligopeptide transport
NRO40_RS11610	COG1316	TRANSCRIPTIONal
NRO40_RS11625	COG0297	glycogen (starch) synthase activity
NRO40_RS11630	COG0489	protein tyrosine kinase activity
NRO40_RS11665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NRO40_RS11670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NRO40_RS11675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRO40_RS11685	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS11690	COG1191	sigma factor activity
NRO40_RS11695	COG2226	methyltransferase
NRO40_RS11705	COG1228	amidohydrolase
NRO40_RS11720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NRO40_RS11725	COG0019	diaminopimelate decarboxylase activity
NRO40_RS11795	COG0183	Belongs to the thiolase family
NRO40_RS11825	COG1136	(ABC) transporter
NRO40_RS11835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NRO40_RS11840	COG1252	NADH dehydrogenase
NRO40_RS11870	COG0148	phosphopyruvate hydratase activity
NRO40_RS11885	COG2124	cytochrome p450
NRO40_RS11925	COG0515	serine threonine protein kinase
NRO40_RS11925	COG2815	serine threonine protein kinase
NRO40_RS11965	COG2814	Major facilitator Superfamily
NRO40_RS12020	COG4585	Histidine kinase
NRO40_RS12030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NRO40_RS12035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NRO40_RS12040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NRO40_RS12045	COG0193	aminoacyl-tRNA hydrolase activity
NRO40_RS12060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NRO40_RS12075	COG4106	trans-aconitate 2-methyltransferase activity
NRO40_RS12080	COG1846	Transcriptional regulator
NRO40_RS12085	COG2197	response regulator
NRO40_RS12090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NRO40_RS12120	COG0488	(ABC) transporter
NRO40_RS12140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NRO40_RS12145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NRO40_RS12155	COG0084	hydrolase, TatD family'
NRO40_RS12235	COG1122	ATPase activity
NRO40_RS12245	COG0310	cobalt ion transport
NRO40_RS12255	COG2409	Drug exporters of the RND superfamily
NRO40_RS12270	COG0793	Belongs to the peptidase S41A family
NRO40_RS12270	COG4946	Tricorn protease homolog
NRO40_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS12290	COG2072	flavoprotein involved in K transport
NRO40_RS12315	COG0708	Exodeoxyribonuclease III
NRO40_RS12340	COG0252	asparaginase activity
NRO40_RS12390	COG0521	Mo-molybdopterin cofactor biosynthetic process
NRO40_RS12395	COG0315	cyclic pyranopterin monophosphate synthase activity
NRO40_RS12405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NRO40_RS12410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NRO40_RS12435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NRO40_RS12445	COG1970	mechanosensitive ion channel activity
NRO40_RS12470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRO40_RS12470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NRO40_RS12470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NRO40_RS12480	COG1349	DNA-binding transcription factor activity
NRO40_RS12485	COG0477	Major facilitator Superfamily
NRO40_RS12510	COG3384	dioxygenase
NRO40_RS12515	COG1846	Transcriptional regulator
NRO40_RS12535	COG0318	PFAM AMP-dependent synthetase and ligase
NRO40_RS12610	COG1686	Belongs to the peptidase S11 family
NRO40_RS12645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRO40_RS12650	COG1120	ATPase activity
NRO40_RS12660	COG0546	phosphoglycolate phosphatase activity
NRO40_RS12675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRO40_RS12685	COG0477	Major facilitator Superfamily
NRO40_RS12735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NRO40_RS12740	COG0475	glutathione-regulated potassium exporter activity
NRO40_RS12810	COG1695	Transcriptional regulator
NRO40_RS12830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NRO40_RS12845	COG2318	DinB family
NRO40_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS12900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRO40_RS12900	COG0515	serine threonine protein kinase
NRO40_RS12910	COG1309	transcriptional regulator
NRO40_RS12915	COG0259	pyridoxamine-phosphate oxidase activity
NRO40_RS12925	COG2072	flavoprotein involved in K transport
NRO40_RS12950	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS13005	COG2945	thiolester hydrolase activity
NRO40_RS13005	COG0596	Alpha beta hydrolase
NRO40_RS13015	COG4821	SIS domain
NRO40_RS13025	COG0259	pyridoxamine-phosphate oxidase activity
NRO40_RS13045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRO40_RS13085	COG0277	FAD linked oxidase domain protein
NRO40_RS13090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NRO40_RS13135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRO40_RS13170	COG3973	AAA domain
NRO40_RS13185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NRO40_RS13190	COG1737	Transcriptional regulator
NRO40_RS13225	COG3973	AAA domain
NRO40_RS13230	COG1131	(ABC) transporter
NRO40_RS13245	COG1061	Type III restriction enzyme res subunit
NRO40_RS13280	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NRO40_RS13285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NRO40_RS13295	COG2814	Major facilitator Superfamily
NRO40_RS13310	COG1595	DNA-templated transcription, initiation
NRO40_RS13325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NRO40_RS13335	COG2252	PERMEase
NRO40_RS13360	COG0667	Aldo Keto reductase
NRO40_RS13420	COG0463	Glycosyl transferase, family 2
NRO40_RS13445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRO40_RS13515	COG2197	response regulator
NRO40_RS13545	COG3842	ATPase activity
NRO40_RS13555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NRO40_RS13570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NRO40_RS13575	COG0215	cysteine-tRNA ligase activity
NRO40_RS13580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NRO40_RS13585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NRO40_RS13590	COG1329	Transcriptional regulator
NRO40_RS13605	COG5002	protein histidine kinase activity
NRO40_RS13625	COG0583	DNA-binding transcription factor activity
NRO40_RS13635	COG0588	phosphoglycerate mutase activity
NRO40_RS13650	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS13685	COG2897	thiosulfate sulfurtransferase activity
NRO40_RS13695	COG3973	AAA domain
NRO40_RS13720	COG4552	Acetyltransferase involved in intracellular survival and related
NRO40_RS13730	COG1490	D-aminoacyl-tRNA deacylase activity
NRO40_RS13740	COG0735	belongs to the Fur family
NRO40_RS13745	COG3485	protocatechuate 3,4-dioxygenase
NRO40_RS13765	COG2897	thiosulfate sulfurtransferase activity
NRO40_RS13790	COG0745	RESPONSE REGULATOR receiver
NRO40_RS13795	COG1609	Transcriptional regulator
NRO40_RS13800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRO40_RS13805	COG0745	RESPONSE REGULATOR receiver
NRO40_RS13820	COG0737	Belongs to the 5'-nucleotidase family
NRO40_RS13825	COG0456	acetyltransferase
NRO40_RS13830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NRO40_RS13845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NRO40_RS13865	COG0306	phosphate transporter
NRO40_RS13875	COG1937	Protein conserved in bacteria
NRO40_RS13895	COG0277	FAD linked oxidase domain protein
NRO40_RS13900	COG0671	phosphoesterase, PA-phosphatase related
NRO40_RS13905	COG0741	lytic transglycosylase activity
NRO40_RS13905	COG1196	nuclear chromosome segregation
NRO40_RS13905	COG0739	heme binding
NRO40_RS13950	COG1131	(ABC) transporter
NRO40_RS13960	COG4585	Histidine kinase
NRO40_RS13965	COG2197	response regulator
NRO40_RS14030	COG0579	oxidoreductase
NRO40_RS14035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NRO40_RS14045	COG0739	heme binding
NRO40_RS14045	COG0741	lytic transglycosylase activity
NRO40_RS14045	COG1196	nuclear chromosome segregation
NRO40_RS14065	COG0513	Belongs to the DEAD box helicase family
NRO40_RS14110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRO40_RS14110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRO40_RS14120	COG1643	Atp-dependent helicase
NRO40_RS14155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NRO40_RS14175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRO40_RS14180	COG0047	phosphoribosylformylglycinamidine synthase activity
NRO40_RS14185	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NRO40_RS14220	COG2197	response regulator
NRO40_RS14230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NRO40_RS14245	COG0151	Belongs to the GarS family
NRO40_RS14380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NRO40_RS14395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NRO40_RS14405	COG1741	Belongs to the pirin family
NRO40_RS14455	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS14465	COG1362	aminopeptidase activity
NRO40_RS14505	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRO40_RS14515	COG0022	dehydrogenase e1 component
NRO40_RS14530	COG0515	serine threonine protein kinase
NRO40_RS14535	COG0515	serine threonine protein kinase
NRO40_RS14550	COG4591	ABC-type transport system involved in lipoprotein release permease component
NRO40_RS14550	COG1136	(ABC) transporter
NRO40_RS14570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NRO40_RS14575	COG0303	'Molybdopterin
NRO40_RS14580	COG0746	molybdenum cofactor guanylyltransferase activity
NRO40_RS14610	COG1522	sequence-specific DNA binding
NRO40_RS14615	COG1309	transcriptional regulator
NRO40_RS14620	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRO40_RS14645	COG3396	Phenylacetate-CoA oxygenase
NRO40_RS14650	COG3460	Phenylacetate-CoA oxygenase
NRO40_RS14655	COG3396	Phenylacetate-CoA oxygenase
NRO40_RS14660	COG2151	metal-sulfur cluster biosynthetic enzyme
NRO40_RS14665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NRO40_RS14670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NRO40_RS14690	COG1716	ATPase activity
NRO40_RS14695	COG1716	ATPase activity
NRO40_RS14710	COG0768	penicillin binding
NRO40_RS14715	COG0515	serine threonine protein kinase
NRO40_RS14720	COG3764	Sortase (surface protein transpeptidase)
NRO40_RS14725	COG3764	Sortase (surface protein transpeptidase)
NRO40_RS14750	COG0705	Rhomboid family
NRO40_RS14780	COG0515	serine threonine protein kinase
NRO40_RS14800	COG3266	domain, Protein
NRO40_RS14805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NRO40_RS14815	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NRO40_RS14820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NRO40_RS14825	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NRO40_RS14830	COG0592	DNA-directed DNA polymerase activity
NRO40_RS14845	COG0594	ribonuclease P activity
NRO40_RS14850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NRO40_RS14855	COG0706	membrane insertase activity
NRO40_RS14865	COG0357	Ribosomal RNA small subunit methyltransferase G
NRO40_RS14870	COG1192	Involved in chromosome partitioning
NRO40_RS14885	COG3118	belongs to the thioredoxin family
NRO40_RS14890	COG0492	ferredoxin-NADP+ reductase activity
NRO40_RS14900	COG1595	DNA-templated transcription, initiation
NRO40_RS14905	COG0515	serine threonine protein kinase
NRO40_RS14905	COG2815	serine threonine protein kinase
NRO40_RS14920	COG0617	tRNA 3'-terminal CCA addition
NRO40_RS14940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRO40_RS14965	COG0360	Binds together with S18 to 16S ribosomal RNA
NRO40_RS14970	COG0629	single-stranded DNA binding
NRO40_RS14975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NRO40_RS14980	COG0359	binds to the 23S rRNA
NRO40_RS14990	COG0305	Participates in initiation and elongation during chromosome replication
NRO40_RS15080	COG2814	Major facilitator Superfamily
NRO40_RS15100	COG0626	cystathionine gamma-synthase activity
NRO40_RS15105	COG1950	PFAM Membrane protein of
NRO40_RS15110	COG0662	Cupin 2, conserved barrel domain protein
NRO40_RS15135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NRO40_RS15145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NRO40_RS15150	COG1609	Transcriptional regulator
NRO40_RS15155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRO40_RS15165	COG1271	oxidase subunit
NRO40_RS15170	COG1294	oxidase, subunit
NRO40_RS15175	COG4988	ABC transporter
NRO40_RS15180	COG1196	nuclear chromosome segregation
NRO40_RS15180	COG0741	lytic transglycosylase activity
NRO40_RS15180	COG0739	heme binding
NRO40_RS15185	COG0561	phosphatase activity
NRO40_RS15195	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NRO40_RS15200	COG0789	Transcriptional regulator
NRO40_RS15225	COG1131	(ABC) transporter
NRO40_RS15240	COG0561	phosphatase activity
NRO40_RS15245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NRO40_RS15255	COG2837	iron assimilation
NRO40_RS15260	COG2372	response to copper ion
NRO40_RS15270	COG1999	signal sequence binding
NRO40_RS15290	COG0006	proline dipeptidase activity
NRO40_RS15310	COG0653	protein targeting
NRO40_RS15325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRO40_RS15380	COG3739	integral membrane protein
NRO40_RS15385	COG1595	DNA-templated transcription, initiation
NRO40_RS15390	COG0318	PFAM AMP-dependent synthetase and ligase
NRO40_RS15435	COG0745	RESPONSE REGULATOR receiver
NRO40_RS15440	COG0477	Major facilitator Superfamily
NRO40_RS15465	COG1191	sigma factor activity
NRO40_RS15470	COG1191	sigma factor activity
NRO40_RS15505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NRO40_RS15530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRO40_RS15535	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NRO40_RS15620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRO40_RS15625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NRO40_RS15730	COG1278	Cold shock
NRO40_RS15735	COG0513	Belongs to the DEAD box helicase family
NRO40_RS15755	COG0730	response to heat
NRO40_RS15765	COG0745	RESPONSE REGULATOR receiver
NRO40_RS15780	COG0513	Belongs to the DEAD box helicase family
NRO40_RS15785	COG1278	Cold shock
NRO40_RS15830	COG4932	domain protein
NRO40_RS15830	COG5492	domain, Protein
NRO40_RS15860	COG0717	Belongs to the dCTP deaminase family
NRO40_RS15875	COG0247	lactate metabolic process
NRO40_RS15875	COG2181	nitrate reductase activity
NRO40_RS15880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRO40_RS15885	COG0443	Heat shock 70 kDa protein
NRO40_RS15890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NRO40_RS15895	COG0484	heat shock protein binding
NRO40_RS15900	COG0789	Transcriptional regulator
NRO40_RS15920	COG0542	response to heat
NRO40_RS15945	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NRO40_RS15960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NRO40_RS15965	COG0191	fructose-bisphosphate aldolase activity
NRO40_RS15970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NRO40_RS15990	COG3844	kynureninase activity
NRO40_RS16005	COG4585	Histidine kinase
NRO40_RS16010	COG2197	response regulator
NRO40_RS16015	COG2124	cytochrome p450
NRO40_RS16020	COG3559	Exporter of polyketide antibiotics
NRO40_RS16025	COG1131	(ABC) transporter
NRO40_RS16040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NRO40_RS16065	COG1309	transcriptional regulator
NRO40_RS16085	COG2890	protein-(glutamine-N5) methyltransferase activity
NRO40_RS16095	COG0693	protein deglycase activity
NRO40_RS16100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRO40_RS16105	COG1802	Transcriptional regulator
NRO40_RS16125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NRO40_RS16130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NRO40_RS16160	COG1595	DNA-templated transcription, initiation
NRO40_RS16190	COG0546	phosphoglycolate phosphatase activity
NRO40_RS16215	COG1408	metallophosphoesterase
NRO40_RS16225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRO40_RS16235	COG0003	Pfam Anion-transporting ATPase
NRO40_RS16260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRO40_RS16285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRO40_RS16295	COG2267	carboxylic ester hydrolase activity
NRO40_RS16305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRO40_RS16310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRO40_RS16315	COG0659	secondary active sulfate transmembrane transporter activity
NRO40_RS16375	COG1205	dead DEAH box helicase
NRO40_RS16375	COG1111	helicase
NRO40_RS16380	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS16385	COG2172	sigma factor antagonist activity
NRO40_RS16390	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NRO40_RS16400	COG2890	protein-(glutamine-N5) methyltransferase activity
NRO40_RS16410	COG1754	DNA topoisomerase type I activity
NRO40_RS16410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NRO40_RS16415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NRO40_RS16420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NRO40_RS16440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRO40_RS16445	COG1280	lysine exporter protein (LysE YggA)
NRO40_RS16485	COG2304	oxidoreductase activity
NRO40_RS16520	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS16525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NRO40_RS16535	COG0728	peptidoglycan biosynthetic process
NRO40_RS16545	COG0438	transferase activity, transferring glycosyl groups
NRO40_RS16615	COG2197	response regulator
NRO40_RS16625	COG0110	maltose O-acetyltransferase activity
NRO40_RS16635	COG1733	regulation of RNA biosynthetic process
NRO40_RS16650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NRO40_RS16655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NRO40_RS16660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRO40_RS16665	COG0254	rRNA binding
NRO40_RS16670	COG0523	cobalamin synthesis protein
NRO40_RS16675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NRO40_RS16695	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS16700	COG2318	DinB family
NRO40_RS16710	COG0789	Transcriptional regulator
NRO40_RS16715	COG0393	Putative heavy-metal-binding
NRO40_RS16730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NRO40_RS16735	COG2027	D-alanyl-D-alanine carboxypeptidase
NRO40_RS16745	COG0037	tRNA processing
NRO40_RS16760	COG0302	gtp cyclohydrolase
NRO40_RS16775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NRO40_RS16790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NRO40_RS16790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NRO40_RS16805	COG1174	glycine betaine transport
NRO40_RS16810	COG1174	glycine betaine transport
NRO40_RS16825	COG0649	NAD binding
NRO40_RS16840	COG2197	response regulator
NRO40_RS16845	COG1660	Displays ATPase and GTPase activities
NRO40_RS16865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NRO40_RS16870	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NRO40_RS16880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NRO40_RS16900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NRO40_RS16920	COG2027	D-alanyl-D-alanine carboxypeptidase
NRO40_RS16925	COG0739	heme binding
NRO40_RS16930	COG2205	protein histidine kinase activity
NRO40_RS16935	COG0745	RESPONSE REGULATOR receiver
NRO40_RS16945	COG1595	DNA-templated transcription, initiation
NRO40_RS16950	COG1194	a g-specific adenine glycosylase
NRO40_RS16965	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NRO40_RS16985	COG0248	Ppx GppA phosphatase
NRO40_RS16990	COG1082	Xylose isomerase domain protein TIM barrel
NRO40_RS16995	COG0129	dihydroxy-acid dehydratase activity
NRO40_RS17000	COG0515	serine threonine protein kinase
NRO40_RS17000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NRO40_RS17005	COG4991	sh3 domain protein
NRO40_RS17015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NRO40_RS17020	COG0180	Tryptophanyl-tRNA synthetase
NRO40_RS17040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRO40_RS17100	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NRO40_RS17105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NRO40_RS17110	COG0181	hydroxymethylbilane synthase activity
NRO40_RS17115	COG1648	precorrin-2 dehydrogenase activity
NRO40_RS17115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NRO40_RS17140	COG2318	DinB family
NRO40_RS17155	COG0596	Alpha beta hydrolase
NRO40_RS17160	COG0113	porphobilinogen synthase activity
NRO40_RS17195	COG0018	arginyl-trna synthetase
NRO40_RS17200	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NRO40_RS17225	COG1690	Belongs to the RtcB family
NRO40_RS17260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NRO40_RS17265	COG0406	alpha-ribazole phosphatase activity
NRO40_RS17285	COG1333	cytochrome c biogenesis protein
NRO40_RS17290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NRO40_RS17315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NRO40_RS17335	COG0163	prenyltransferase activity
NRO40_RS17350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NRO40_RS17365	COG1301	dicarboxylic acid transport
NRO40_RS17370	COG1309	transcriptional regulator
NRO40_RS17400	COG0582	viral genome integration into host DNA
NRO40_RS17430	COG2188	Transcriptional regulator
NRO40_RS17480	COG1278	Cold shock
NRO40_RS17485	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NRO40_RS17495	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NRO40_RS17505	COG2226	methyltransferase
NRO40_RS17545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRO40_RS17550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRO40_RS17555	COG0649	NAD binding
NRO40_RS17565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NRO40_RS17570	COG1034	ATP synthesis coupled electron transport
NRO40_RS17575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NRO40_RS17580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRO40_RS17585	COG0839	Belongs to the complex I subunit 6 family
NRO40_RS17590	COG0713	ATP synthesis coupled electron transport
NRO40_RS17595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NRO40_RS17605	COG1007	ATP synthesis coupled electron transport
NRO40_RS17615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NRO40_RS17615	COG2207	Transcriptional regulator
NRO40_RS17620	COG3485	protocatechuate 3,4-dioxygenase
NRO40_RS17625	COG0179	Fumarylacetoacetate (FAA) hydrolase
NRO40_RS17630	COG0142	geranyltranstransferase activity
NRO40_RS17640	COG4935	Belongs to the peptidase S8 family
NRO40_RS17640	COG2234	aminopeptidase activity
NRO40_RS17650	COG1013	pyruvate-flavodoxin oxidoreductase activity
NRO40_RS17655	COG0674	pyruvate-flavodoxin oxidoreductase activity
NRO40_RS17655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NRO40_RS17675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRO40_RS17680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRO40_RS17685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRO40_RS17690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NRO40_RS17695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NRO40_RS17705	COG0713	ATP synthesis coupled electron transport
NRO40_RS17710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NRO40_RS17720	COG1007	ATP synthesis coupled electron transport
NRO40_RS17725	COG0501	Belongs to the peptidase M48B family
NRO40_RS17730	COG3304	Inner membrane component domain
NRO40_RS17740	COG2261	transglycosylase associated protein
NRO40_RS17750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NRO40_RS17755	COG1666	GTP binding
NRO40_RS17765	COG0702	epimerase
NRO40_RS17770	COG0402	S-adenosylhomocysteine deaminase activity
NRO40_RS17785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NRO40_RS17790	COG2030	dehydratase
NRO40_RS17800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NRO40_RS17805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRO40_RS17810	COG0436	Aminotransferase
NRO40_RS17830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NRO40_RS17835	COG0081	regulation of translation
NRO40_RS17845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NRO40_RS17850	COG0222	ribosome binding
NRO40_RS17855	COG0085	RNA polymerase activity
NRO40_RS17860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NRO40_RS17865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NRO40_RS17870	COG0049	tRNA binding
NRO40_RS17875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NRO40_RS17880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NRO40_RS17905	COG0051	transcription antitermination factor activity, RNA binding
NRO40_RS17910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NRO40_RS17915	COG0088	Forms part of the polypeptide exit tunnel
NRO40_RS17920	COG0089	rRNA binding
NRO40_RS17925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NRO40_RS17930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NRO40_RS17935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NRO40_RS17940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NRO40_RS17945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NRO40_RS17950	COG0255	Belongs to the universal ribosomal protein uL29 family
NRO40_RS17955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NRO40_RS17960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NRO40_RS17965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NRO40_RS17970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NRO40_RS17975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NRO40_RS17980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NRO40_RS17985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NRO40_RS17990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NRO40_RS17995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NRO40_RS18000	COG1841	ribosomal large subunit assembly
NRO40_RS18005	COG0200	Binds to the 23S rRNA
NRO40_RS18010	COG0201	protein transport
NRO40_RS18015	COG0563	adenylate kinase activity
NRO40_RS18025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NRO40_RS18030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NRO40_RS18035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NRO40_RS18040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NRO40_RS18045	COG0202	RNA polymerase activity
NRO40_RS18050	COG0203	ribosomal protein L17
NRO40_RS18055	COG0101	tRNA pseudouridine synthase activity
NRO40_RS18070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NRO40_RS18075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NRO40_RS18080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRO40_RS18090	COG1072	(Pantothenic acid kinase))
NRO40_RS18100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRO40_RS18105	COG0736	holo-[acyl-carrier-protein] synthase activity
NRO40_RS18120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NRO40_RS18130	COG0802	atpase or kinase
NRO40_RS18145	COG0456	acetyltransferase
NRO40_RS18145	COG1214	PFAM Peptidase M22, glycoprotease
NRO40_RS18155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NRO40_RS18165	COG0726	polysaccharide deacetylase
NRO40_RS18180	COG0726	polysaccharide deacetylase
NRO40_RS18185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NRO40_RS18190	COG0459	protein refolding
NRO40_RS18205	COG0583	DNA-binding transcription factor activity
NRO40_RS18215	COG2197	response regulator
NRO40_RS18220	COG1595	DNA-templated transcription, initiation
NRO40_RS18230	COG0516	GMP reductase activity
NRO40_RS18245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NRO40_RS18250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NRO40_RS18265	COG0515	serine threonine protein kinase
NRO40_RS18275	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS18295	COG0519	Catalyzes the synthesis of GMP from XMP
NRO40_RS18295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NRO40_RS18320	COG2197	response regulator
NRO40_RS18360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS18360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS18380	COG0714	Associated with various cellular activities
NRO40_RS18390	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NRO40_RS18395	COG0045	succinate-CoA ligase (ADP-forming) activity
NRO40_RS18430	COG0138	bifunctional purine biosynthesis protein purh
NRO40_RS18460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NRO40_RS18475	COG0039	L-malate dehydrogenase activity
NRO40_RS18480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NRO40_RS18480	COG2755	lipolytic protein G-D-S-L family
NRO40_RS18485	COG1476	TRANSCRIPTIONal
NRO40_RS18495	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS18505	COG4175	Glycine betaine
NRO40_RS18505	COG0517	IMP dehydrogenase activity
NRO40_RS18510	COG4176	ABC-type proline glycine betaine transport system permease component
NRO40_RS18520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NRO40_RS18525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRO40_RS18530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRO40_RS18540	COG0754	glutathionylspermidine amidase activity
NRO40_RS18545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRO40_RS18550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRO40_RS18555	COG0180	Tryptophanyl-tRNA synthetase
NRO40_RS18565	COG1295	ribonuclease BN
NRO40_RS18570	COG1686	Belongs to the peptidase S11 family
NRO40_RS18580	COG1408	metallophosphoesterase
NRO40_RS18585	COG4166	transmembrane transport
NRO40_RS18610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NRO40_RS18615	COG1053	succinate dehydrogenase
NRO40_RS18625	COG2009	succinate dehydrogenase
NRO40_RS18635	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NRO40_RS18665	COG1595	DNA-templated transcription, initiation
NRO40_RS18680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS18680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS18705	COG1473	amidohydrolase
NRO40_RS18705	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NRO40_RS18710	COG1744	ABC transporter substrate-binding protein PnrA-like
NRO40_RS18715	COG3845	ABC transporter
NRO40_RS18725	COG1079	Belongs to the binding-protein-dependent transport system permease family
NRO40_RS18760	COG2814	Major facilitator Superfamily
NRO40_RS18765	COG0583	DNA-binding transcription factor activity
NRO40_RS18775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRO40_RS18800	COG2205	protein histidine kinase activity
NRO40_RS18805	COG0745	RESPONSE REGULATOR receiver
NRO40_RS18810	COG1595	DNA-templated transcription, initiation
NRO40_RS18825	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS18830	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS18835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NRO40_RS18865	COG2318	DinB family
NRO40_RS18870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NRO40_RS18900	COG4770	biotin carboxylase activity
NRO40_RS18910	COG0424	maF-like protein
NRO40_RS18920	COG4566	intracellular signal transduction
NRO40_RS18935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRO40_RS18950	COG1024	Enoyl-CoA hydratase
NRO40_RS18960	COG2986	histidine ammonia-lyase
NRO40_RS18975	COG1376	ErfK ybiS ycfS ynhG family protein
NRO40_RS18985	COG1064	alcohol dehydrogenase
NRO40_RS18995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRO40_RS19010	COG0501	Belongs to the peptidase M48B family
NRO40_RS19040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NRO40_RS19055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NRO40_RS19065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NRO40_RS19080	COG1331	Highly conserved protein containing a thioredoxin domain
NRO40_RS19090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NRO40_RS19115	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NRO40_RS19130	COG1414	Transcriptional regulator
NRO40_RS19220	COG2885	chlorophyll binding
NRO40_RS19240	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NRO40_RS19245	COG0667	Aldo Keto reductase
NRO40_RS19250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NRO40_RS19255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NRO40_RS19275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRO40_RS19280	COG0450	alkyl hydroperoxide reductase
NRO40_RS19295	COG1136	(ABC) transporter
NRO40_RS19320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRO40_RS19320	COG4499	WXG100 protein secretion system (Wss), protein YukC
NRO40_RS19335	COG0114	fumarate hydratase activity
NRO40_RS19345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NRO40_RS19345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NRO40_RS19380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NRO40_RS19385	COG1570	exodeoxyribonuclease VII activity
NRO40_RS19390	COG1722	exodeoxyribonuclease VII activity
NRO40_RS19395	COG0778	Nitroreductase
NRO40_RS19405	COG0012	GTP binding
NRO40_RS19420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRO40_RS19480	COG1217	gtp-binding protein TYPA
NRO40_RS19485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRO40_RS19490	COG0747	negative chemotaxis
NRO40_RS19495	COG0601	transmembrane transport
NRO40_RS19500	COG0444	Belongs to the ABC transporter superfamily
NRO40_RS19505	COG4608	Belongs to the ABC transporter superfamily
NRO40_RS19510	COG4166	transmembrane transport
NRO40_RS19515	COG0601	transmembrane transport
NRO40_RS19520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRO40_RS19525	COG0444	Belongs to the ABC transporter superfamily
NRO40_RS19530	COG4608	Belongs to the ABC transporter superfamily
NRO40_RS19545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NRO40_RS19590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRO40_RS19595	COG1611	Belongs to the LOG family
NRO40_RS19600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NRO40_RS19615	COG1024	Enoyl-CoA hydratase
NRO40_RS19630	COG1595	DNA-templated transcription, initiation
NRO40_RS19640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NRO40_RS19645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NRO40_RS19680	COG0598	Magnesium transport protein CorA
NRO40_RS19695	COG0613	PHP domain protein
NRO40_RS19700	COG2095	MarC family integral membrane protein
NRO40_RS19710	COG1432	Conserved Protein
NRO40_RS19720	COG0513	Belongs to the DEAD box helicase family
NRO40_RS19750	COG0596	Alpha beta hydrolase
NRO40_RS19750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NRO40_RS19810	COG0210	DNA helicase
NRO40_RS19815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRO40_RS19855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NRO40_RS19910	COG3480	Lon protease (S16) C-terminal proteolytic domain
NRO40_RS19920	COG1615	UPF0182 protein
NRO40_RS19945	COG0753	catalase activity
NRO40_RS19955	COG0483	inositol monophosphate 1-phosphatase activity
NRO40_RS19965	COG2076	Multidrug Resistance protein
NRO40_RS19975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NRO40_RS19985	COG2135	peptidase activity
NRO40_RS19995	COG1595	DNA-templated transcription, initiation
NRO40_RS20000	COG5662	AntiSigma factor
NRO40_RS20005	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NRO40_RS20005	COG2199	diguanylate cyclase activity
NRO40_RS20020	COG0242	peptide deformylase activity
NRO40_RS20060	COG2188	Transcriptional regulator
NRO40_RS20065	COG2182	Extracellular solute-binding protein
NRO40_RS20070	COG1175	transmembrane transport
NRO40_RS20075	COG0395	ABC-type sugar transport system, permease component
NRO40_RS20080	COG1472	Belongs to the glycosyl hydrolase 3 family
NRO40_RS20085	COG0363	glucosamine-6-phosphate deaminase activity
NRO40_RS20090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NRO40_RS20095	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS20115	COG1597	lipid kinase activity
NRO40_RS20135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NRO40_RS20140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRO40_RS20145	COG0142	geranyltranstransferase activity
NRO40_RS20195	COG1126	abc transporter atp-binding protein
NRO40_RS20220	COG3540	Alkaline phosphatase
NRO40_RS20225	COG0604	alcohol dehydrogenase
NRO40_RS20260	COG0508	dehydrogenase complex catalyzes the overall conversion of
NRO40_RS20260	COG0567	Dehydrogenase, E1 component
NRO40_RS20265	COG2205	protein histidine kinase activity
NRO40_RS20270	COG0745	RESPONSE REGULATOR receiver
NRO40_RS20300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NRO40_RS20315	COG2197	response regulator
NRO40_RS20370	COG1309	transcriptional regulator
NRO40_RS20390	COG0772	Belongs to the SEDS family
NRO40_RS20395	COG2205	protein histidine kinase activity
NRO40_RS20415	COG1793	dna ligase
NRO40_RS20420	COG1793	dna ligase
NRO40_RS20420	COG3285	dna ligase
NRO40_RS20425	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NRO40_RS20440	COG0515	serine threonine protein kinase
NRO40_RS20455	COG1653	transport
NRO40_RS20485	COG0210	DNA helicase
NRO40_RS20520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRO40_RS20575	COG0745	RESPONSE REGULATOR receiver
NRO40_RS20580	COG0018	arginyl-trna synthetase
NRO40_RS20585	COG0019	diaminopimelate decarboxylase activity
NRO40_RS20590	COG0460	homoserine dehydrogenase
NRO40_RS20595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NRO40_RS20600	COG0083	homoserine kinase activity
NRO40_RS20615	COG1316	TRANSCRIPTIONal
NRO40_RS20620	COG0254	rRNA binding
NRO40_RS20625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NRO40_RS20630	COG2890	protein-(glutamine-N5) methyltransferase activity
NRO40_RS20640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRO40_RS20645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRO40_RS20665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRO40_RS20670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NRO40_RS20675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NRO40_RS20680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NRO40_RS20685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NRO40_RS20690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NRO40_RS20695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NRO40_RS20710	COG2197	response regulator
NRO40_RS20715	COG4585	Histidine kinase
NRO40_RS20730	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRO40_RS20745	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NRO40_RS20780	COG1131	(ABC) transporter
NRO40_RS20800	COG0183	Belongs to the thiolase family
NRO40_RS20865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS20865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS20905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NRO40_RS20910	COG0280	phosphate acetyltransferase
NRO40_RS20910	COG0857	belongs to the CobB CobQ family
NRO40_RS20915	COG0205	6-phosphofructokinase activity
NRO40_RS20930	COG4565	transcriptional regulatory protein
NRO40_RS20935	COG3290	protein histidine kinase activity
NRO40_RS20940	COG1301	dicarboxylic acid transport
NRO40_RS20955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NRO40_RS20970	COG0366	Alpha amylase catalytic
NRO40_RS20995	COG0058	SHG alpha-glucan phosphorylase activity
NRO40_RS21005	COG0789	Transcriptional regulator
NRO40_RS21035	COG1132	(ABC) transporter
NRO40_RS21040	COG1132	(ABC) transporter
NRO40_RS21085	COG1760	l-serine dehydratase
NRO40_RS21090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NRO40_RS21095	COG0509	glycine decarboxylation via glycine cleavage system
NRO40_RS21100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRO40_RS21120	COG0747	negative chemotaxis
NRO40_RS21125	COG0601	transmembrane transport
NRO40_RS21130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRO40_RS21135	COG0444	Belongs to the ABC transporter superfamily
NRO40_RS21140	COG4608	Belongs to the ABC transporter superfamily
NRO40_RS21145	COG2860	membrane
NRO40_RS21155	COG1309	transcriptional regulator
NRO40_RS21180	COG0482	sulfurtransferase activity
NRO40_RS21200	COG4221	oxidoreductase activity
NRO40_RS21210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NRO40_RS21220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NRO40_RS21225	COG0154	amidase activity
NRO40_RS21235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NRO40_RS21240	COG2409	Drug exporters of the RND superfamily
NRO40_RS21250	COG2133	pyrroloquinoline quinone binding
NRO40_RS21255	COG0667	Aldo Keto reductase
NRO40_RS21275	COG0440	acetolactate synthase activity
NRO40_RS21280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NRO40_RS21305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRO40_RS21320	COG0506	proline dehydrogenase activity
NRO40_RS21325	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS21340	COG0473	3-isopropylmalate dehydrogenase activity
NRO40_RS21345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NRO40_RS21355	COG0832	Belongs to the urease beta subunit family
NRO40_RS21355	COG0831	urea catabolic process
NRO40_RS21360	COG0804	urea catabolic process
NRO40_RS21365	COG2957	Belongs to the agmatine deiminase family
NRO40_RS21380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NRO40_RS21395	COG2353	YceI-like domain
NRO40_RS21405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NRO40_RS21425	COG2018	Roadblock/LC7 domain
NRO40_RS21445	COG2018	Roadblock/LC7 domain
NRO40_RS21450	COG5002	protein histidine kinase activity
NRO40_RS21460	COG0179	Fumarylacetoacetate (FAA) hydrolase
NRO40_RS21465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NRO40_RS21500	COG1414	Transcriptional regulator
NRO40_RS21505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NRO40_RS21510	COG0066	3-isopropylmalate dehydratase activity
NRO40_RS21520	COG0776	regulation of translation
NRO40_RS21530	COG1920	GTP binding
NRO40_RS21540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NRO40_RS21545	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRO40_RS21565	COG0351	phosphomethylpyrimidine kinase
NRO40_RS21570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NRO40_RS21575	COG1461	Dihydroxyacetone kinase
NRO40_RS21580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NRO40_RS21585	COG0742	ribosomal rna small subunit methyltransferase
NRO40_RS21590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NRO40_RS21605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NRO40_RS21610	COG0571	ribonuclease III activity
NRO40_RS21615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRO40_RS21620	COG0655	NAD(P)H dehydrogenase (quinone) activity
NRO40_RS21635	COG2340	Cysteine-rich secretory protein family
NRO40_RS21640	COG1254	Belongs to the acylphosphatase family
NRO40_RS21650	COG1196	nuclear chromosome segregation
NRO40_RS21655	COG0477	Major facilitator Superfamily
NRO40_RS21690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NRO40_RS21710	COG0228	four-way junction DNA binding
NRO40_RS21715	COG1837	Belongs to the UPF0109 family
NRO40_RS21720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NRO40_RS21725	COG0336	Belongs to the RNA methyltransferase TrmD family
NRO40_RS21730	COG0335	large ribosomal subunit rRNA binding
NRO40_RS21735	COG0681	Belongs to the peptidase S26 family
NRO40_RS21745	COG0681	Belongs to the peptidase S26 family
NRO40_RS21750	COG0681	Belongs to the peptidase S26 family
NRO40_RS21765	COG0792	nuclease activity
NRO40_RS21780	COG1191	sigma factor activity
NRO40_RS21795	COG0052	Belongs to the universal ribosomal protein uS2 family
NRO40_RS21800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NRO40_RS21805	COG0528	UMP kinase activity
NRO40_RS21810	COG0233	cytoplasmic translational termination
NRO40_RS21820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NRO40_RS21830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NRO40_RS21835	COG3842	ATPase activity
NRO40_RS21850	COG1136	(ABC) transporter
NRO40_RS21855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRO40_RS21865	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS21890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRO40_RS21920	COG3842	ATPase activity
NRO40_RS21925	COG1176	ABC-type spermidine putrescine transport system, permease component I
NRO40_RS21930	COG1177	transmembrane transport
NRO40_RS21935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRO40_RS21965	COG2508	Transcriptional regulator
NRO40_RS21970	COG0697	spore germination
NRO40_RS21975	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS22005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NRO40_RS22010	COG0750	zinc metalloprotease
NRO40_RS22015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NRO40_RS22030	COG0442	prolyl-tRNA aminoacylation
NRO40_RS22035	COG0330	HflC and HflK could
NRO40_RS22055	COG0779	Required for maturation of 30S ribosomal subunits
NRO40_RS22070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NRO40_RS22080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NRO40_RS22085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NRO40_RS22100	COG0455	bacterial-type flagellum organization
NRO40_RS22120	COG3266	domain, Protein
NRO40_RS22125	COG1404	Belongs to the peptidase S8 family
NRO40_RS22140	COG1404	Belongs to the peptidase S8 family
NRO40_RS22155	COG1674	ftsk spoiiie
NRO40_RS22165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NRO40_RS22170	COG1185	polyribonucleotide nucleotidyltransferase activity
NRO40_RS22175	COG0612	Peptidase, M16
NRO40_RS22180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NRO40_RS22200	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NRO40_RS22205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NRO40_RS22210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NRO40_RS22235	COG2208	phosphoserine phosphatase activity
NRO40_RS22235	COG2770	Histidine kinase
NRO40_RS22250	COG1674	ftsk spoiiie
NRO40_RS22260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRO40_RS22275	COG1396	sequence-specific DNA binding
NRO40_RS22280	COG0783	Belongs to the Dps family
NRO40_RS22290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRO40_RS22295	COG1201	RNA secondary structure unwinding
NRO40_RS22325	COG0628	permease
NRO40_RS22335	COG1271	oxidase subunit
NRO40_RS22340	COG2197	response regulator
NRO40_RS22350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NRO40_RS22360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRO40_RS22365	COG0765	amino acid transport
NRO40_RS22370	COG0765	amino acid transport
NRO40_RS22375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NRO40_RS22380	COG1126	abc transporter atp-binding protein
NRO40_RS22390	COG2205	protein histidine kinase activity
NRO40_RS22400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NRO40_RS22420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NRO40_RS22430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NRO40_RS22435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NRO40_RS22445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NRO40_RS22455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NRO40_RS22465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NRO40_RS22470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NRO40_RS22475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NRO40_RS22500	COG0488	(ABC) transporter
NRO40_RS22510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NRO40_RS22550	COG1802	Transcriptional regulator
NRO40_RS22555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NRO40_RS22570	COG0187	DNA topoisomerase II activity
NRO40_RS22580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRO40_RS22585	COG2755	lipolytic protein G-D-S-L family
NRO40_RS22590	COG3290	protein histidine kinase activity
NRO40_RS22600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NRO40_RS22605	COG0612	Peptidase, M16
NRO40_RS22620	COG1802	Transcriptional regulator
NRO40_RS22625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NRO40_RS22630	COG1042	CoA-binding domain protein
NRO40_RS22630	COG0045	succinate-CoA ligase (ADP-forming) activity
NRO40_RS22630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRO40_RS22645	COG1435	thymidine kinase activity
NRO40_RS22675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NRO40_RS22690	COG0745	RESPONSE REGULATOR receiver
NRO40_RS22695	COG2205	protein histidine kinase activity
NRO40_RS22720	COG0756	dUTP diphosphatase activity
NRO40_RS22755	COG0569	domain protein
NRO40_RS22760	COG0531	amino acid
NRO40_RS22765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NRO40_RS22775	COG3251	PFAM MbtH domain protein
NRO40_RS22785	COG1131	(ABC) transporter
NRO40_RS22800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRO40_RS22810	COG0367	asparagine synthase
NRO40_RS22825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRO40_RS22875	COG1278	Cold shock
NRO40_RS22885	COG1278	Cold shock
NRO40_RS22935	COG1233	COG1233 Phytoene dehydrogenase and related
NRO40_RS22950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRO40_RS22955	COG0604	alcohol dehydrogenase
NRO40_RS22955	COG0604	alcohol dehydrogenase
NRO40_RS22955	COG3321	synthase
NRO40_RS22955	COG3321	synthase
NRO40_RS22965	COG2267	carboxylic ester hydrolase activity
NRO40_RS22975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NRO40_RS22980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NRO40_RS23000	COG4566	intracellular signal transduction
NRO40_RS23005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRO40_RS23020	COG3833	ABC-type maltose transport systems, permease component
NRO40_RS23025	COG1175	transmembrane transport
NRO40_RS23035	COG3250	beta-galactosidase activity
NRO40_RS23040	COG1609	Transcriptional regulator
NRO40_RS23050	COG1482	cell wall glycoprotein biosynthetic process
NRO40_RS23120	COG0596	Alpha beta hydrolase
NRO40_RS23125	COG1864	DNA RNA non-specific endonuclease
NRO40_RS23125	COG3591	Belongs to the peptidase S1B family
NRO40_RS23145	COG1799	cell septum assembly
NRO40_RS23175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NRO40_RS23225	COG0515	serine threonine protein kinase
NRO40_RS23240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRO40_RS23245	COG0006	proline dipeptidase activity
NRO40_RS23260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NRO40_RS23260	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRO40_RS23275	COG3938	Belongs to the proline racemase family
NRO40_RS23300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NRO40_RS23320	COG0640	Transcriptional regulator
NRO40_RS23400	COG1278	Cold shock
NRO40_RS23405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NRO40_RS23410	COG2409	Drug exporters of the RND superfamily
NRO40_RS23420	COG4941	Belongs to the sigma-70 factor family
NRO40_RS23430	COG0142	geranyltranstransferase activity
NRO40_RS23445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NRO40_RS23460	COG1653	transport
NRO40_RS23465	COG1175	transmembrane transport
NRO40_RS23470	COG0395	ABC-type sugar transport system, permease component
NRO40_RS23480	COG4213	ABC transporter substrate-binding protein
NRO40_RS23490	COG4214	carbohydrate transport
NRO40_RS23495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NRO40_RS23500	COG0531	amino acid
NRO40_RS23510	COG0514	ATP-dependent DNA helicase (RecQ)
NRO40_RS23520	COG1024	Enoyl-CoA hydratase
NRO40_RS23520	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRO40_RS23525	COG0183	Belongs to the thiolase family
NRO40_RS23535	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NRO40_RS23550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NRO40_RS23570	COG3220	belongs to the UPF0276 family
NRO40_RS23575	COG3253	May function as heme-dependent peroxidase
NRO40_RS23580	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NRO40_RS23590	COG0446	pyridine nucleotide-disulphide oxidoreductase
NRO40_RS23625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NRO40_RS23630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NRO40_RS23650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRO40_RS23655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NRO40_RS23680	COG0540	Belongs to the ATCase OTCase family
NRO40_RS23685	COG2814	Major facilitator Superfamily
NRO40_RS23695	COG0529	Catalyzes the synthesis of activated sulfate
NRO40_RS23710	COG0475	glutathione-regulated potassium exporter activity
NRO40_RS23730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NRO40_RS23740	COG0028	Belongs to the TPP enzyme family
NRO40_RS23740	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
NRO40_RS23750	COG1012	belongs to the aldehyde dehydrogenase family
NRO40_RS23785	COG1716	ATPase activity
NRO40_RS23810	COG2267	carboxylic ester hydrolase activity
NRO40_RS23830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NRO40_RS23835	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NRO40_RS23855	COG0529	Catalyzes the synthesis of activated sulfate
NRO40_RS23860	COG0175	sulfate reduction
NRO40_RS23870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NRO40_RS23885	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS23910	COG0475	glutathione-regulated potassium exporter activity
NRO40_RS23920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NRO40_RS23925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRO40_RS23930	COG0019	diaminopimelate decarboxylase activity
NRO40_RS23935	COG1162	GTPase activity
NRO40_RS23955	COG0028	Belongs to the TPP enzyme family
NRO40_RS24020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRO40_RS24025	COG2252	PERMEase
NRO40_RS24045	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NRO40_RS24060	COG2080	2 iron, 2 sulfur cluster binding
NRO40_RS24065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NRO40_RS24070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NRO40_RS24075	COG2066	Belongs to the glutaminase family
NRO40_RS24080	COG2409	Drug exporters of the RND superfamily
NRO40_RS24085	COG1846	Transcriptional regulator
NRO40_RS24090	COG0702	epimerase
NRO40_RS24110	COG1120	ATPase activity
NRO40_RS24200	COG3634	alkyl hydroperoxide reductase activity
NRO40_RS24205	COG0514	ATP-dependent DNA helicase (RecQ)
NRO40_RS24215	COG1191	sigma factor activity
NRO40_RS24255	COG0598	Magnesium transport protein CorA
NRO40_RS24275	COG0659	secondary active sulfate transmembrane transporter activity
NRO40_RS24290	COG1073	alpha beta
NRO40_RS24290	COG2226	methyltransferase
NRO40_RS24335	COG0598	Magnesium transport protein CorA
NRO40_RS24345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NRO40_RS24360	COG3960	tartronate-semialdehyde synthase activity
NRO40_RS24370	COG0753	catalase activity
NRO40_RS24375	COG2084	Dehydrogenase
NRO40_RS24380	COG3622	Belongs to the hyi family
NRO40_RS24400	COG2351	hydroxyisourate hydrolase activity
NRO40_RS24415	COG2233	PERMEase
NRO40_RS24430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NRO40_RS24450	COG2197	response regulator
NRO40_RS24465	COG1136	(ABC) transporter
NRO40_RS24465	COG0577	efflux transmembrane transporter activity
NRO40_RS24470	COG1414	Transcriptional regulator
NRO40_RS24475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRO40_RS24480	COG4266	Belongs to the allantoicase family
NRO40_RS24490	COG0673	inositol 2-dehydrogenase activity
NRO40_RS24495	COG2188	Transcriptional regulator
NRO40_RS24515	COG1940	carbohydrate kinase activity
NRO40_RS24545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NRO40_RS24565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRO40_RS24565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NRO40_RS24575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NRO40_RS24580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRO40_RS24610	COG0405	Gamma-glutamyltransferase
NRO40_RS24620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NRO40_RS24625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NRO40_RS24650	COG0483	inositol monophosphate 1-phosphatase activity
NRO40_RS24660	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NRO40_RS24685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NRO40_RS24690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NRO40_RS24710	COG1929	Belongs to the glycerate kinase type-1 family
NRO40_RS24725	COG0688	phosphatidylethanolamine metabolic process
NRO40_RS24730	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS24740	COG2301	Belongs to the HpcH HpaI aldolase family
NRO40_RS24745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS24745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NRO40_RS24750	COG0604	alcohol dehydrogenase
NRO40_RS24765	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRO40_RS24830	COG2362	D-Aminopeptidase
NRO40_RS24835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NRO40_RS24845	COG1619	proteins homologs of microcin C7 resistance protein MccF
NRO40_RS24850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NRO40_RS24860	COG0477	Major facilitator Superfamily
NRO40_RS24865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRO40_RS24895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NRO40_RS24910	COG0693	protein deglycase activity
NRO40_RS24915	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NRO40_RS24970	COG0531	amino acid
NRO40_RS24985	COG0583	DNA-binding transcription factor activity
NRO40_RS24990	COG0156	8-amino-7-oxononanoate synthase activity
NRO40_RS24995	COG1063	alcohol dehydrogenase
NRO40_RS25010	COG2154	pterin-4-alpha-carbinolamine dehydratase
NRO40_RS25015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NRO40_RS25020	COG2304	oxidoreductase activity
NRO40_RS25040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NRO40_RS25045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRO40_RS25085	COG0667	Aldo Keto reductase
NRO40_RS25120	COG2040	homocysteine
NRO40_RS25155	COG1486	melibiose metabolic process
NRO40_RS25165	COG3012	SEC-C Motif Domain Protein
NRO40_RS25180	COG1793	dna ligase
NRO40_RS25205	COG0488	(ABC) transporter
NRO40_RS25220	COG1515	deoxyribonuclease V activity
NRO40_RS25230	COG3268	Saccharopine dehydrogenase
NRO40_RS25235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NRO40_RS25240	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS25245	COG0183	Belongs to the thiolase family
NRO40_RS25250	COG1024	Enoyl-CoA hydratase
NRO40_RS25250	COG1250	3-hydroxyacyl-CoA dehydrogenase
NRO40_RS25270	COG0697	spore germination
NRO40_RS25280	COG3568	Endonuclease Exonuclease Phosphatase
NRO40_RS25295	COG0395	ABC-type sugar transport system, permease component
NRO40_RS25325	COG2936	dipeptidyl-peptidase activity
NRO40_RS25335	COG0488	(ABC) transporter
NRO40_RS25345	COG2183	response to ionizing radiation
NRO40_RS25370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NRO40_RS25395	COG0371	Dehydrogenase
NRO40_RS25415	COG1388	LysM domain
NRO40_RS25415	COG1134	teichoic acid transport
NRO40_RS25420	COG1562	ergosterol biosynthetic process
NRO40_RS25430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NRO40_RS25440	COG1657	PFAM Prenyltransferase squalene oxidase
NRO40_RS25460	COG2365	Tyrosine phosphatase family
NRO40_RS25470	COG2755	lipolytic protein G-D-S-L family
NRO40_RS25490	COG1585	Membrane protein implicated in regulation of membrane protease activity
NRO40_RS25495	COG2268	Band 7 protein
NRO40_RS25530	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS25575	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS25580	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NRO40_RS25585	COG1523	belongs to the glycosyl hydrolase 13 family
NRO40_RS25600	COG0366	Alpha amylase catalytic
NRO40_RS25605	COG3833	ABC-type maltose transport systems, permease component
NRO40_RS25615	COG2182	Extracellular solute-binding protein
NRO40_RS25670	COG3842	ATPase activity
NRO40_RS25680	COG2182	Extracellular solute-binding protein
NRO40_RS25685	COG1175	transmembrane transport
NRO40_RS25690	COG0395	ABC-type sugar transport system, permease component
NRO40_RS25695	COG2723	6-phospho-beta-galactosidase activity
NRO40_RS25730	COG1653	transport
NRO40_RS25735	COG1175	transmembrane transport
NRO40_RS25740	COG0395	ABC-type sugar transport system, permease component
NRO40_RS25745	COG0366	Alpha amylase catalytic
NRO40_RS25755	COG1132	(ABC) transporter
NRO40_RS25775	COG0110	maltose O-acetyltransferase activity
NRO40_RS25780	COG3226	Transcriptional regulator
NRO40_RS25860	COG1733	regulation of RNA biosynthetic process
NRO40_RS25865	COG0702	epimerase
NRO40_RS26320	COG0242	peptide deformylase activity
NRO40_RS26375	COG0494	nUDIX hydrolase
NRO40_RS26390	COG1051	belongs to the nudix hydrolase family
NRO40_RS26410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NRO40_RS26425	COG0302	gtp cyclohydrolase
NRO40_RS26430	COG0602	queuosine metabolic process
NRO40_RS26465	COG3387	PFAM Glycoside hydrolase 15-related
NRO40_RS26510	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NRO40_RS26545	COG0270	DNA (cytosine-5-)-methyltransferase activity
NRO40_RS26595	COG2838	Isocitrate dehydrogenase
NRO40_RS26670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NRO40_RS26725	COG0028	Belongs to the TPP enzyme family
NRO40_RS26755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NRO40_RS26760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NRO40_RS26765	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS26775	COG1181	Belongs to the D-alanine--D-alanine ligase family
NRO40_RS26795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NRO40_RS26845	COG0523	cobalamin synthesis protein
NRO40_RS26870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRO40_RS26890	COG0601	transmembrane transport
NRO40_RS26910	COG0477	Major facilitator Superfamily
NRO40_RS26915	COG2890	protein-(glutamine-N5) methyltransferase activity
NRO40_RS26930	COG0667	Aldo Keto reductase
NRO40_RS26950	COG0583	DNA-binding transcription factor activity
NRO40_RS26975	COG2378	regulation of single-species biofilm formation
NRO40_RS27000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NRO40_RS27060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NRO40_RS27110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NRO40_RS27130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NRO40_RS27135	COG3275	phosphorelay sensor kinase activity
NRO40_RS27140	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NRO40_RS27210	COG1053	succinate dehydrogenase
NRO40_RS27215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NRO40_RS27220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRO40_RS27230	COG3360	Dodecin
NRO40_RS27235	COG2182	Extracellular solute-binding protein
NRO40_RS27260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NRO40_RS27265	COG3572	ergothioneine biosynthetic process
NRO40_RS27275	COG0183	Belongs to the thiolase family
NRO40_RS27280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NRO40_RS27295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NRO40_RS27300	COG0395	ABC-type sugar transport system, permease component
NRO40_RS27305	COG1175	transmembrane transport
NRO40_RS27310	COG2182	Extracellular solute-binding protein
NRO40_RS27315	COG2188	Transcriptional regulator
NRO40_RS27330	COG2182	Extracellular solute-binding protein
NRO40_RS27335	COG1175	transmembrane transport
NRO40_RS27340	COG3833	ABC-type maltose transport systems, permease component
NRO40_RS27345	COG2723	6-phospho-beta-galactosidase activity
NRO40_RS27355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NRO40_RS27365	COG3903	Transcriptional regulator
NRO40_RS27365	COG3629	intracellular signal transduction
NRO40_RS27395	COG3469	chitinase activity
NRO40_RS27425	COG0531	amino acid
NRO40_RS27480	COG0367	asparagine synthase
NRO40_RS27485	COG2814	Major facilitator Superfamily
NRO40_RS27525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NRO40_RS27530	COG1120	ATPase activity
NRO40_RS27565	COG4221	oxidoreductase activity
NRO40_RS27570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NRO40_RS27585	COG4935	Belongs to the peptidase S8 family
NRO40_RS27585	COG2234	aminopeptidase activity
NRO40_RS27590	COG0789	Transcriptional regulator
NRO40_RS27595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRO40_RS27600	COG2124	cytochrome p450
NRO40_RS27615	COG1357	PFAM Pentapeptide repeats (8 copies)
NRO40_RS27665	COG3458	cephalosporin-C deacetylase activity
NRO40_RS27690	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS27695	COG1960	acyl-CoA dehydrogenase activity
NRO40_RS27710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NRO40_RS27720	COG1124	(ABC) transporter
NRO40_RS27745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NRO40_RS27755	COG1404	Belongs to the peptidase S8 family
NRO40_RS27765	COG0488	(ABC) transporter
NRO40_RS27770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NRO40_RS27830	COG1597	lipid kinase activity
NRO40_RS27860	COG0789	Transcriptional regulator
NRO40_RS27860	COG4978	Transcriptional regulator
NRO40_RS27865	COG2124	cytochrome p450
NRO40_RS27870	COG2124	cytochrome p450
NRO40_RS27875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NRO40_RS27880	COG2124	cytochrome p450
NRO40_RS27895	COG0328	RNA-DNA hybrid ribonuclease activity
NRO40_RS27935	COG3250	beta-galactosidase activity
NRO40_RS27955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NRO40_RS27960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRO40_RS27990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NRO40_RS28000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NRO40_RS28035	COG2018	Roadblock/LC7 domain
NRO40_RS28050	COG1793	dna ligase
NRO40_RS28060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NRO40_RS28075	COG0726	polysaccharide deacetylase
NRO40_RS28080	COG3437	response regulator, receiver
NRO40_RS28110	COG2124	cytochrome p450
NRO40_RS28115	COG3424	synthase
NRO40_RS28125	COG0726	polysaccharide deacetylase
NRO40_RS28135	COG0300	oxidoreductase activity
NRO40_RS28160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRO40_RS28175	COG1595	DNA-templated transcription, initiation
NRO40_RS28190	COG0477	Major facilitator Superfamily
NRO40_RS28195	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NRO40_RS28200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NRO40_RS28235	COG2249	NAD(P)H dehydrogenase (quinone) activity
NRO40_RS28260	COG0655	NAD(P)H dehydrogenase (quinone) activity
NRO40_RS28280	COG0656	L-ascorbic acid biosynthetic process
NRO40_RS28300	COG2706	6-phosphogluconolactonase activity
NRO40_RS28305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NRO40_RS28330	COG4221	oxidoreductase activity
NRO40_RS28335	COG0142	geranyltranstransferase activity
NRO40_RS28355	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NRO40_RS28360	COG2226	methyltransferase
NRO40_RS28430	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
NRO40_RS28445	COG1819	glycosyl
NRO40_RS28460	COG0714	Associated with various cellular activities
NRO40_RS28490	COG2308	Evidence 4 Homologs of previously reported genes of
NRO40_RS28490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NRO40_RS28495	COG0367	asparagine synthase
NRO40_RS28555	COG0251	oxidation-reduction process
NRO40_RS28635	COG4067	protein conserved in archaea
NRO40_RS28635	COG0189	ligase activity
NRO40_RS28655	COG2207	Transcriptional regulator
NRO40_RS28660	COG2223	nitrite transmembrane transporter activity
NRO40_RS28670	COG1902	pentaerythritol trinitrate reductase activity
NRO40_RS28675	COG0640	Transcriptional regulator
NRO40_RS28685	COG0667	Aldo Keto reductase
NRO40_RS28690	COG5002	protein histidine kinase activity
NRO40_RS28855	COG0494	nUDIX hydrolase
NRO40_RS28885	COG1335	isochorismatase
NRO40_RS28980	COG0346	lactoylglutathione lyase activity
NRO40_RS28985	COG0640	Transcriptional regulator
NRO40_RS28995	COG0789	Transcriptional regulator
NRO40_RS29000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NRO40_RS29010	COG0640	Transcriptional regulator
NRO40_RS29025	COG1295	ribonuclease BN
NRO40_RS29035	COG4989	oxidoreductase activity
NRO40_RS29045	COG2208	phosphoserine phosphatase activity
NRO40_RS29045	COG2770	Histidine kinase
NRO40_RS29055	COG0488	(ABC) transporter
NRO40_RS29060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NRO40_RS29080	COG3896	Chloramphenicol phosphotransferase-like protein
NRO40_RS29085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NRO40_RS29095	COG0798	PFAM Bile acid sodium symporter
NRO40_RS29100	COG1742	UPF0060 membrane protein
NRO40_RS29110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NRO40_RS29115	COG1115	amino acid carrier protein
NRO40_RS29120	COG1595	DNA-templated transcription, initiation
NRO40_RS29130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NRO40_RS29270	COG1309	transcriptional regulator
NRO40_RS29280	COG0657	acetylesterase activity
NRO40_RS29300	COG4977	sequence-specific DNA binding
NRO40_RS29320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NRO40_RS29330	COG1509	lysine 2,3-aminomutase activity
NRO40_RS29335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NRO40_RS29365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRO40_RS29385	COG0667	Aldo Keto reductase
NRO40_RS29390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NRO40_RS29425	COG1132	(ABC) transporter
NRO40_RS29445	COG3507	Belongs to the glycosyl hydrolase 43 family
NRO40_RS29465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NRO40_RS29475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NRO40_RS29490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NRO40_RS29575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NRO40_RS29590	COG0475	glutathione-regulated potassium exporter activity
NRO40_RS29630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NRO40_RS29635	COG0431	NADPH-dependent FMN reductase
NRO40_RS29640	COG2814	Major facilitator Superfamily
NRO40_RS29670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NRO40_RS29675	COG0596	Alpha beta hydrolase
NRO40_RS29710	COG0300	oxidoreductase activity
NRO40_RS29725	COG0604	alcohol dehydrogenase
NRO40_RS29725	COG3321	synthase
NRO40_RS29725	COG1028	Short-chain dehydrogenase reductase Sdr
NRO40_RS29730	COG2409	Drug exporters of the RND superfamily
NRO40_RS29735	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS29770	COG1366	Belongs to the anti-sigma-factor antagonist family
NRO40_RS30210	COG0539	negative regulation of cytoplasmic translation
NRO40_RS30360	COG0017	Asparaginyl-tRNA synthetase
NRO40_RS30415	COG2318	DinB family
NRO40_RS30480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins