locus-tag class description GSY65_RS00245 ENOG4108HMN Caspase domain GSY65_RS00265 ENOG4105D5G Transposase GSY65_RS00330 ENOG4105PWE CRISPR-associated protein cas2 GSY65_RS00335 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GSY65_RS00375 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GSY65_RS00430 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GSY65_RS00450 ENOG4105FBW Monooxygenase GSY65_RS00455 ENOG4107RSM transcriptional regulator GSY65_RS00460 ENOG4105DEN Luciferase family GSY65_RS00470 ENOG4105CPU Monooxygenase GSY65_RS00475 ENOG4105CPU Monooxygenase GSY65_RS00485 ENOG4105EAB amino acid AbC transporter GSY65_RS00490 ENOG4105CDA abc transporter atp-binding protein GSY65_RS00495 ENOG4105DRP amino acid AbC transporter GSY65_RS00510 ENOG4105CHR reductase GSY65_RS00525 ENOG4105C57 major facilitator superfamily GSY65_RS00555 ENOG4107RCI amp-dependent synthetase and ligase GSY65_RS00580 ENOG4106IBS oxygenase GSY65_RS00610 ENOG4105CPP Dehydrogenase, E1 component GSY65_RS00620 ENOG4107RUY (E1 component), alpha subunit GSY65_RS00625 ENOG4107SCK Monooxygenase GSY65_RS00630 ENOG4105DIN metallophosphoesterase GSY65_RS00635 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GSY65_RS00655 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GSY65_RS00710 ENOG4105CJ1 ABC, transporter GSY65_RS00720 ENOG4105BZU Histidine kinase GSY65_RS00725 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS00810 ENOG4105NAE bifunctional deaminase-reductase domain protein GSY65_RS00830 ENOG4108ZBR Gcn5-related n-acetyltransferase GSY65_RS00835 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GSY65_RS00865 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS00875 ENOG4107MMM Anti-sigma-factor antagonist GSY65_RS00880 ENOG4105FUA antagonist GSY65_RS00885 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GSY65_RS00930 ENOG4107YCR Transcriptional regulator, ARSR family GSY65_RS00935 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GSY65_RS00940 ENOG4105H3G oxidoreductase GSY65_RS00960 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GSY65_RS00970 ENOG4105CPC Aldo Keto reductase GSY65_RS00975 ENOG4105E8G Major facilitator Superfamily GSY65_RS00990 ENOG4107VIJ nudix hydrolase GSY65_RS01020 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GSY65_RS01050 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GSY65_RS01055 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GSY65_RS01060 ENOG4105WBV Transcriptional regulator GSY65_RS01080 ENOG410880H cysteine synthase GSY65_RS01100 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GSY65_RS01105 ENOG4105E0A ABC, transporter GSY65_RS01110 ENOG4108IHU transport system permease protein GSY65_RS01115 ENOG4105DQ5 transport system permease protein GSY65_RS01135 ENOG4105BZ1 (ABC) transporter GSY65_RS01140 ENOG4105BZ1 (ABC) transporter GSY65_RS01160 ENOG4108YZG isomerase GSY65_RS01190 ENOG4105CPC Aldo Keto reductase GSY65_RS01195 ENOG4108M0I Transcriptional regulator GSY65_RS01210 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GSY65_RS01215 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GSY65_RS01255 ENOG4105CGD Nad-dependent epimerase dehydratase GSY65_RS01260 ENOG4105CVP deoxyribo-dipyrimidine photolyase GSY65_RS01270 ENOG4105DU6 RNA polymerase GSY65_RS01290 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GSY65_RS01325 ENOG4105KF0 sporulation and cell division protein, SsgA GSY65_RS01375 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 GSY65_RS01400 ENOG4105E39 Enoyl-CoA hydratase GSY65_RS01410 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GSY65_RS01415 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS01445 ENOG4105K6V RNA polymerase GSY65_RS01450 ENOG4105RNG membrane GSY65_RS01475 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GSY65_RS01480 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GSY65_RS01490 ENOG4105BZ8 glutamate synthase GSY65_RS01505 ENOG4105BZU Histidine kinase GSY65_RS01520 ENOG4105X7H acyl-CoA dehydrogenase GSY65_RS01555 ENOG41082SX arsR family transcriptional regulator GSY65_RS01570 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GSY65_RS01585 ENOG4108JJB ABC transporter GSY65_RS01610 ENOG4105DIA mandelate racemase muconate lactonizing GSY65_RS01615 ENOG4105ERH Fumarylacetoacetate hydrolase GSY65_RS01635 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GSY65_RS01695 ENOG4108IUW ABC transporter GSY65_RS01715 ENOG4107QQG Dehydrogenase GSY65_RS01740 ENOG4105DC1 bifunctional purine biosynthesis protein purh GSY65_RS01785 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein GSY65_RS01795 ENOG4105CPC Aldo Keto reductase GSY65_RS01820 ENOG4105DSG hydrolase family 43 GSY65_RS01835 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GSY65_RS01915 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GSY65_RS01930 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GSY65_RS01940 ENOG4105F1A Pyruvate formate-lyase GSY65_RS01965 ENOG41080XP Cbs domain GSY65_RS01990 ENOG4108YV4 Universal stress protein GSY65_RS02000 ENOG4105CHH sulfate transporter GSY65_RS02060 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GSY65_RS02070 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS02075 ENOG4105BZU Histidine kinase GSY65_RS02105 ENOG41064MX Tetr family transcriptional regulator GSY65_RS02130 ENOG4105C57 major facilitator superfamily GSY65_RS02140 ENOG4105DGU Histone deacetylase GSY65_RS02150 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GSY65_RS02155 ENOG4105F1N DNA alkylation repair GSY65_RS02165 ENOG4105C0W non-ribosomal peptide synthetase GSY65_RS02180 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GSY65_RS02195 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GSY65_RS02210 ENOG4105CMT Dihydroxyacetone kinase GSY65_RS02215 ENOG4108UTZ Dihydroxyacetone kinase GSY65_RS02230 ENOG4105CYP glycoside hydrolase, family GSY65_RS02245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GSY65_RS02250 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GSY65_RS02280 ENOG4107QN1 sodium solute GSY65_RS02285 ENOG4105I82 acetyl xylan esterase GSY65_RS02295 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GSY65_RS02300 ENOG4105CG3 alpha amylase, catalytic region GSY65_RS02315 ENOG4105DZ1 carboxypeptidase GSY65_RS02320 ENOG4105CSV Glutaminase GSY65_RS02325 ENOG4108IJ0 Aspartate ammonia-lyase GSY65_RS02345 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GSY65_RS02350 ENOG41083TI Protein CrcB homolog GSY65_RS02355 ENOG4105KJJ Uncharacterized ACR, COG1993 GSY65_RS02360 ENOG41083YR Protein CrcB homolog GSY65_RS02390 ENOG4105D56 permease protein GSY65_RS02395 ENOG4105I1K ABC transporter GSY65_RS02400 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS02430 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GSY65_RS02440 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GSY65_RS02445 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GSY65_RS02460 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GSY65_RS02500 ENOG4108IAJ Nad-dependent epimerase dehydratase GSY65_RS02510 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GSY65_RS02540 ENOG4105DFW ABC transporter GSY65_RS02550 ENOG4105DFW ABC transporter GSY65_RS02555 ENOG4105C2J ABC transporter GSY65_RS02560 ENOG4107RNG ABC transporter GSY65_RS02650 ENOG4106A3M Cytochrome p-450 GSY65_RS02655 ENOG4106YKD Cytochrome p-450 GSY65_RS02685 ENOG4108JA1 polyketide synthase GSY65_RS02710 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GSY65_RS02725 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component GSY65_RS02730 ENOG4108IJ7 Glycine betaine GSY65_RS02735 ENOG4105C26 Dehydrogenase GSY65_RS02750 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GSY65_RS02760 ENOG4105DVW rieske (2Fe-2S) GSY65_RS02765 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase GSY65_RS02770 ENOG4105VQD rieske 2fe-2S domain-containing protein GSY65_RS02785 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GSY65_RS02820 ENOG4105EPJ extracellular solute-binding protein family 1 GSY65_RS02825 ENOG4107S91 Sodium hydrogen exchanger GSY65_RS02860 ENOG4107RRZ synthase GSY65_RS02885 ENOG4106F1P AAA ATPase, central domain protein GSY65_RS02895 ENOG4105MVE transcriptional regulator GSY65_RS02920 ENOG4105E2R ROK family GSY65_RS02925 ENOG4105CF1 Alkylated DNA repair protein GSY65_RS02930 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) GSY65_RS02945 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GSY65_RS02950 ENOG4105E98 transcriptional regulator DeoR family GSY65_RS02990 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GSY65_RS02995 ENOG4107PP3 Acetylornithine deacetylase GSY65_RS03000 ENOG4105I1F Resistance protein GSY65_RS03015 ENOG41060NJ transcriptional regulator GSY65_RS03040 ENOG4105C10 Electron transfer flavoprotein GSY65_RS03065 ENOG4105PSQ Acyl-transferase GSY65_RS03075 ENOG4105C5W Aldolase GSY65_RS03090 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GSY65_RS03110 ENOG4105FS7 Transcriptional regulator GSY65_RS03125 ENOG410841Q phosphoesterase PA-phosphatase related protein GSY65_RS03155 ENOG4105EQH reductase GSY65_RS03160 ENOG4105YVS arsR family transcriptional regulator GSY65_RS03165 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GSY65_RS03170 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GSY65_RS03210 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GSY65_RS03225 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GSY65_RS03240 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GSY65_RS03245 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GSY65_RS03250 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GSY65_RS03255 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GSY65_RS03260 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GSY65_RS03270 ENOG4105CPN adenine deaminase GSY65_RS03275 ENOG4105CUB amino acid GSY65_RS03310 ENOG4105C7W Xanthine dehydrogenase GSY65_RS03315 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GSY65_RS03320 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GSY65_RS03355 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GSY65_RS03375 ENOG4105E90 ABC transporter GSY65_RS03380 ENOG4108IJ8 ABC transporter GSY65_RS03395 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GSY65_RS03400 ENOG4108KGH TRANSCRIPTIONal GSY65_RS03425 ENOG4105CNN ABC, transporter GSY65_RS03430 ENOG4105C2J ABC transporter GSY65_RS03435 ENOG4108MJI response regulator GSY65_RS03445 ENOG4107U9T Pfam:Ribonuclease_BN GSY65_RS03460 ENOG4107ZED Uncharacterised protein family UPF0047 GSY65_RS03465 ENOG4105H3G oxidoreductase GSY65_RS03485 ENOG4105CK2 sodium dicarboxylate symporter GSY65_RS03505 ENOG4105BZ1 (ABC) transporter GSY65_RS03525 ENOG4105C29 acyl-CoA thioesterase GSY65_RS03535 ENOG4105GWZ Roadblock lc7 family protein GSY65_RS03575 ENOG4105C0D helicase GSY65_RS03595 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) GSY65_RS03605 ENOG4107RR1 TRANSCRIPTIONal GSY65_RS03610 ENOG4105C26 Dehydrogenase GSY65_RS03620 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GSY65_RS03625 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GSY65_RS03630 ENOG4105C7W Xanthine dehydrogenase GSY65_RS03635 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GSY65_RS03685 ENOG4108MXF Alpha Beta Hydrolase GSY65_RS03700 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GSY65_RS03705 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GSY65_RS03740 ENOG4105ERH Fumarylacetoacetate hydrolase GSY65_RS03750 ENOG41061H0 Monooxygenase GSY65_RS03765 ENOG4105ERH Fumarylacetoacetate hydrolase GSY65_RS03785 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GSY65_RS03795 ENOG4105CHR reductase GSY65_RS03840 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS03855 ENOG41082AN stage II sporulation protein GSY65_RS03860 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid GSY65_RS03875 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS03895 ENOG4105BZU Histidine kinase GSY65_RS03900 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GSY65_RS03905 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component GSY65_RS03915 ENOG4105CG3 alpha amylase, catalytic region GSY65_RS03920 ENOG4107T3P ABC, transporter GSY65_RS03930 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GSY65_RS03940 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS03955 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GSY65_RS03970 ENOG4108PC0 lipolytic protein G-D-S-L family GSY65_RS04035 ENOG4105DBA pectate lyase GSY65_RS04060 ENOG4105D2B acyl-CoA dehydrogenase GSY65_RS04065 ENOG4105D2B acyl-CoA dehydrogenase GSY65_RS04070 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GSY65_RS04080 ENOG4105C3M thioredoxin reductase GSY65_RS04085 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GSY65_RS04110 ENOG4106A3M Cytochrome p-450 GSY65_RS04115 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS04125 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GSY65_RS04135 ENOG4105F1K Glutamine amidotransferase GSY65_RS04140 ENOG4105CTQ phosphohexokinase GSY65_RS04155 ENOG4108HRK Histidine kinase GSY65_RS04170 ENOG4108NEV two component transcriptional regulator, LytTR family GSY65_RS04180 ENOG4105CIK Amidinotransferase GSY65_RS04185 ENOG4105C8Y Acetylornithine aminotransferase GSY65_RS04210 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GSY65_RS04220 ENOG4105CQM Urea amidohydrolase subunit alpha GSY65_RS04225 ENOG4105KI2 Urea amidohydrolase subunit beta GSY65_RS04230 ENOG4108YZ9 Urea amidohydrolase subunit gamma GSY65_RS04235 ENOG4108Q5F Tetr family transcriptional regulator GSY65_RS04295 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GSY65_RS04300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GSY65_RS04305 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GSY65_RS04335 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS04340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS04345 ENOG4105FBW Monooxygenase GSY65_RS04375 ENOG4108EKI Dehydrogenase GSY65_RS04410 ENOG4105C83 adenylosuccinate lyase GSY65_RS04415 ENOG4108VCA G U mismatch-specific DNA glycosylase GSY65_RS04420 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GSY65_RS04440 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GSY65_RS04575 ENOG4105DKQ ROK family GSY65_RS04580 ENOG4105FDP GntR family transcriptional regulator GSY65_RS04585 ENOG4108KPJ rna polymerase sigma factor GSY65_RS04590 ENOG4106HB6 Alpha beta hydrolase GSY65_RS04655 ENOG4105EYH Exonuclease GSY65_RS04660 ENOG4107RH8 nuclease SbcCD subunit D GSY65_RS04665 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GSY65_RS04680 ENOG4105K4P CoA-binding domain protein GSY65_RS04685 ENOG4108YV4 Universal stress protein GSY65_RS04695 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB GSY65_RS04720 ENOG4108UW5 maltose o-acetyltransferase GSY65_RS04725 ENOG4108Z0R Transferase GSY65_RS04735 ENOG4105EBR Carboxylesterase GSY65_RS04760 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GSY65_RS04785 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GSY65_RS04800 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GSY65_RS04810 ENOG4105FQP Beta-lactamase GSY65_RS04825 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GSY65_RS04835 ENOG4105EP9 oxidoreductase GSY65_RS04855 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GSY65_RS04860 ENOG4108J59 Extracellular solute-binding protein, family 5 GSY65_RS04865 ENOG4105CHR reductase GSY65_RS04905 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GSY65_RS04925 ENOG4105DSG hydrolase family 43 GSY65_RS04940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GSY65_RS04945 ENOG4105DEF Extracellular solute-binding protein, family 5 GSY65_RS04950 ENOG41060NJ transcriptional regulator GSY65_RS04960 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GSY65_RS04980 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GSY65_RS04995 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GSY65_RS05005 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GSY65_RS05015 ENOG4108Z86 Glutamine amidotransferase GSY65_RS05020 ENOG4105C26 Dehydrogenase GSY65_RS05065 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) GSY65_RS05080 ENOG4105C5F glutamine synthetase GSY65_RS05105 ENOG4105C5Q Transcriptional regulator GSY65_RS05115 ENOG4105CSW GntR family transcriptional regulator GSY65_RS05155 ENOG4107TIF Phenazine biosynthesis protein, PhzF family GSY65_RS05180 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GSY65_RS05190 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GSY65_RS05210 ENOG4108UW8 fha domain-containing protein GSY65_RS05260 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GSY65_RS05270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GSY65_RS05295 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GSY65_RS05300 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GSY65_RS05315 ENOG4105GWZ Roadblock lc7 family protein GSY65_RS05330 ENOG4105C26 Dehydrogenase GSY65_RS05335 ENOG4105CUB amino acid GSY65_RS05370 ENOG4107RGD Major Facilitator superfamily GSY65_RS05375 ENOG4105CFM UPF0317 protein GSY65_RS05380 ENOG4105E7W lamb ycsf family protein GSY65_RS05385 ENOG4105P4J Allophanate hydrolase, subunit 1 GSY65_RS05390 ENOG4107R7A Allophanate hydrolase subunit 2 GSY65_RS05395 ENOG41090WU lipolytic protein G-D-S-L family GSY65_RS05400 ENOG4108MJN Glycosyl Transferase GSY65_RS05415 ENOG4105JXB ankyrin repeat-containing protein GSY65_RS05430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GSY65_RS05435 ENOG4108VW9 Membrane GSY65_RS05445 ENOG4105DEU major facilitator superfamily GSY65_RS05450 ENOG4105Q70 GSY65_RS05455 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GSY65_RS05460 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GSY65_RS05470 ENOG4105EW9 transcriptional regulator AsnC family GSY65_RS05480 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS05485 ENOG41067SE Tetr family transcriptional regulator GSY65_RS05525 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GSY65_RS05530 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GSY65_RS05535 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GSY65_RS05540 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GSY65_RS05555 ENOG4105ECP epimerase GSY65_RS05560 ENOG4105E2R ROK family GSY65_RS05610 ENOG4105CUB amino acid GSY65_RS05625 ENOG4105DKT Transcriptional regulator GSY65_RS05630 ENOG4105DJV ribulose-phosphate 3-epimerase GSY65_RS05635 ENOG4105EYF MMPL domain protein GSY65_RS05645 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GSY65_RS05660 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GSY65_RS05670 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GSY65_RS05675 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GSY65_RS05685 ENOG4105SKN orotidine 5''-phosphate decarboxylase GSY65_RS05690 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GSY65_RS05695 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GSY65_RS05700 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GSY65_RS05710 ENOG4105CD3 dihydroorotase GSY65_RS05715 ENOG4105CXT aspartate transcarbamylase GSY65_RS05720 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GSY65_RS05730 ENOG410803B Involved in the transcription termination process (By similarity) GSY65_RS05735 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GSY65_RS05740 ENOG4105DC7 peptidase M24 GSY65_RS05750 ENOG4105D49 3-dehydroquinate synthase GSY65_RS05755 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GSY65_RS05760 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GSY65_RS05775 ENOG4105E2X shikimate dehydrogenase GSY65_RS05780 ENOG4105HHA aminodeoxychorismate lyase GSY65_RS05785 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GSY65_RS05790 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GSY65_RS05805 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GSY65_RS05820 ENOG4105CUT histidyl-tRNA synthetase GSY65_RS05830 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GSY65_RS05835 ENOG4105C99 atpase involved in dna repair GSY65_RS05840 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GSY65_RS05845 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GSY65_RS05850 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GSY65_RS05855 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GSY65_RS05865 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GSY65_RS05870 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GSY65_RS05875 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GSY65_RS05880 ENOG4105CDY transcriptional regulatory protein GSY65_RS05885 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GSY65_RS05890 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GSY65_RS05900 ENOG4105E2K Glycosyl transferase (Group 1 GSY65_RS05905 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GSY65_RS05910 ENOG4108VTU Cdp-alcohol phosphatidyltransferase GSY65_RS05930 ENOG4105C22 threonyL-tRNA synthetase GSY65_RS05945 ENOG4108JDX DNA polymerase iii, epsilon subunit GSY65_RS05965 ENOG4105EKC GSY65_RS05975 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GSY65_RS05980 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GSY65_RS06000 ENOG4105KF0 sporulation and cell division protein, SsgA GSY65_RS06030 ENOG4105CRQ synthase (Component I) GSY65_RS06085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GSY65_RS06090 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GSY65_RS06105 ENOG4105D01 (LipO)protein GSY65_RS06110 ENOG4108UMI ABC transporter, permease GSY65_RS06115 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GSY65_RS06140 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GSY65_RS06145 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS06155 ENOG4105C57 major facilitator superfamily GSY65_RS06160 ENOG4105RJZ Transcriptional regulator GSY65_RS06170 ENOG4105CH7 arginosuccinase GSY65_RS06205 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GSY65_RS06210 ENOG4105C8Y Acetylornithine aminotransferase GSY65_RS06215 ENOG4105CAS nag kinase GSY65_RS06220 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GSY65_RS06225 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GSY65_RS06260 ENOG4105T38 integral membrane protein GSY65_RS06270 ENOG4105F32 YngK protein GSY65_RS06285 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GSY65_RS06300 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GSY65_RS06305 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GSY65_RS06310 ENOG4105BZU Histidine kinase GSY65_RS06315 ENOG4108RWN rrna methyltransferase GSY65_RS06320 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GSY65_RS06325 ENOG41084BS 50S ribosomal protein L35 GSY65_RS06330 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GSY65_RS06350 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY65_RS06375 ENOG4105C26 Dehydrogenase GSY65_RS06380 ENOG4105C5F glutamine synthetase GSY65_RS06390 ENOG4105CUB amino acid GSY65_RS06395 ENOG4108Z86 Glutamine amidotransferase GSY65_RS06425 ENOG4105HFS 5'-3' exonuclease GSY65_RS06445 ENOG4105D3G Pseudouridine synthase GSY65_RS06490 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GSY65_RS06520 ENOG4108V1T peptidylprolyl cis-trans isomerase GSY65_RS06525 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GSY65_RS06535 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS06540 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GSY65_RS06545 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GSY65_RS06555 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GSY65_RS06560 ENOG4105E5F proteasome GSY65_RS06565 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GSY65_RS06600 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS06605 ENOG4108J59 Extracellular solute-binding protein, family 5 GSY65_RS06610 ENOG4108J59 Extracellular solute-binding protein, family 5 GSY65_RS06615 ENOG4107URF beta-phospho-glucomutase GSY65_RS06625 ENOG4105C3R Methionine synthase GSY65_RS06630 ENOG4108K8U Glycerol operon regulatory protein GSY65_RS06635 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GSY65_RS06640 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GSY65_RS06645 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GSY65_RS06655 ENOG4105JXH GntR family transcriptional regulator GSY65_RS06670 ENOG4105C8N cysteinyl-tRNA synthetase GSY65_RS06685 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GSY65_RS06690 ENOG4105D7N magnesium and cobalt transport protein CorA GSY65_RS06700 ENOG4105DYW oxidoreductase GSY65_RS06705 ENOG4105CPC Aldo Keto reductase GSY65_RS06750 ENOG4105CD8 aminopeptidase N GSY65_RS06755 ENOG4105K5B UPF0225 protein GSY65_RS06760 ENOG4105C6F GntR Family Transcriptional Regulator GSY65_RS06765 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GSY65_RS06770 ENOG4105C6Z Gluconate GSY65_RS06785 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein GSY65_RS06795 ENOG4105PTV Nudix Hydrolase GSY65_RS06800 ENOG4105VG5 Membrane GSY65_RS06805 ENOG4105JP4 Inner membrane protein yidG GSY65_RS06825 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS06830 ENOG4108IG5 Transcriptional regulator GSY65_RS06840 ENOG4105EHZ conserved protein UCP016719 GSY65_RS06865 ENOG4108Z4X TRANSCRIPTIONal GSY65_RS06875 ENOG4107T94 Endo-14-beta-xylanase GSY65_RS06880 ENOG4107T94 Endo-14-beta-xylanase GSY65_RS06895 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS06905 ENOG410631K Membrane GSY65_RS06945 ENOG4105D4T Citrate transporter GSY65_RS06950 ENOG4108J2R molybdopterin oxidoreductase GSY65_RS06955 ENOG4108SGK Tetr family transcriptional regulator GSY65_RS06960 ENOG4105F1J Homogentisate 1,2-dioxygenase GSY65_RS06965 ENOG4105FDP GntR family transcriptional regulator GSY65_RS06995 ENOG4105RNG membrane GSY65_RS07000 ENOG4105K6V RNA polymerase GSY65_RS07015 ENOG41061MD high-affinity nickel-transporter GSY65_RS07020 ENOG4105D9P serine threonine protein kinase GSY65_RS07025 ENOG4108TCJ secreted hydrolase GSY65_RS07045 ENOG4108SHN Glycosyl transferase, family 2 GSY65_RS07050 ENOG4107BJW polysaccharide deacetylase GSY65_RS07075 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GSY65_RS07115 ENOG4108Z2K Cupin 2, conserved barrel domain protein GSY65_RS07120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GSY65_RS07125 ENOG4105C0B DNA polymerase III (alpha subunit) GSY65_RS07140 ENOG4106NMR serine protease GSY65_RS07150 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GSY65_RS07155 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS07160 ENOG4105C57 major facilitator superfamily GSY65_RS07170 ENOG410841Q phosphoesterase PA-phosphatase related protein GSY65_RS07180 ENOG4105BZ9 Cytochrome C oxidase, subunit I GSY65_RS07195 ENOG4108I69 Glycosyl transferases group 1 GSY65_RS07210 ENOG4108IV0 ABC, transporter GSY65_RS07215 ENOG4105MS9 Resuscitation-promoting factor GSY65_RS07230 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GSY65_RS07240 ENOG4105CAT Cytidine monophosphate kinase GSY65_RS07260 ENOG410756H nucleotidyltransferase GSY65_RS07265 ENOG410756H nucleotidyltransferase GSY65_RS07280 ENOG4105FE9 pseudouridine synthase GSY65_RS07285 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GSY65_RS07290 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GSY65_RS07305 ENOG4105DCF alanine dehydrogenase GSY65_RS07315 ENOG4108YZ4 nudix hydrolase GSY65_RS07320 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GSY65_RS07325 ENOG4105BZP glycoside hydrolase 15-related GSY65_RS07345 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GSY65_RS07355 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GSY65_RS07375 ENOG4105E0A ABC, transporter GSY65_RS07380 ENOG4105TVJ transport system, permease GSY65_RS07385 ENOG4105DQ5 transport system permease protein GSY65_RS07390 ENOG4105DSU hydrolase GSY65_RS07425 ENOG4108VX5 3-methyladenine DNA glycosylase GSY65_RS07435 ENOG4108V1U phospholipid-binding protein GSY65_RS07455 ENOG4105DKW ABC transporter GSY65_RS07470 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS07490 ENOG4105IDI abc transporter atp-binding protein GSY65_RS07500 ENOG4105EAC phosphoserine phosphatase GSY65_RS07505 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GSY65_RS07525 ENOG4107YCY Transcriptional regulator GSY65_RS07540 ENOG4105CHR reductase GSY65_RS07555 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GSY65_RS07560 ENOG4105Y3U Transglycosylase-associated protein GSY65_RS07575 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GSY65_RS07580 ENOG4107QN1 sodium solute GSY65_RS07595 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY65_RS07600 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GSY65_RS07620 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GSY65_RS07650 ENOG4105BZP glycoside hydrolase 15-related GSY65_RS07655 ENOG4105CHR reductase GSY65_RS07690 ENOG41060WC Enoyl-CoA hydratase GSY65_RS07700 ENOG4105C5H ABC transporter GSY65_RS07720 ENOG4107W7X Aldolase GSY65_RS07735 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GSY65_RS07740 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GSY65_RS07745 ENOG4105CTK cobaltochelatase, cobn subunit GSY65_RS07755 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GSY65_RS07760 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GSY65_RS07775 ENOG4105CIA precorrin-4 C(11)-methyltransferase GSY65_RS07785 ENOG4105E4R Precorrin-3B C17-methyltransferase GSY65_RS07805 ENOG4105CDA abc transporter atp-binding protein GSY65_RS07810 ENOG4105EAD ABC transporter GSY65_RS07815 ENOG4105EAB amino acid AbC transporter GSY65_RS07820 ENOG4105C5R Aminotransferase GSY65_RS07830 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GSY65_RS07835 ENOG4108JPW Aminotransferase GSY65_RS07840 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GSY65_RS07845 ENOG4105EV8 ectoine hydroxylase GSY65_RS07855 ENOG4105K6V RNA polymerase GSY65_RS07880 ENOG41069M3 Transcriptional regulator GSY65_RS07885 ENOG4105CJN penicillin-binding protein GSY65_RS07890 ENOG4105C7N Xanthine uracil vitamin C permease GSY65_RS07895 ENOG4105NAF rna polymerase sigma factor GSY65_RS07915 ENOG4105NBR Pectinesterase GSY65_RS07920 ENOG4105NBR Pectinesterase GSY65_RS07930 ENOG4107TDE lipolytic protein G-D-S-L family GSY65_RS07940 ENOG4105E4I Glycoside hydrolase family 28 GSY65_RS07950 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GSY65_RS07955 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GSY65_RS07960 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GSY65_RS07970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GSY65_RS08000 ENOG4105E9Z Nad-dependent epimerase dehydratase GSY65_RS08005 ENOG4105E98 transcriptional regulator DeoR family GSY65_RS08025 ENOG4105CPQ Dehydrogenase GSY65_RS08040 ENOG4107XBN GntR Family Transcriptional Regulator GSY65_RS08090 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GSY65_RS08100 ENOG4105NAF rna polymerase sigma factor GSY65_RS08110 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GSY65_RS08115 ENOG4108RFG Tetr family transcriptional regulator GSY65_RS08120 ENOG4105KPY Small multidrug resistance protein GSY65_RS08130 ENOG4105VG1 fes assembly suf system protein GSY65_RS08135 ENOG4108UNV SUF system FeS assembly protein, NifU family GSY65_RS08140 ENOG4105C9B Cysteine desulfurase GSY65_RS08145 ENOG4105C3K feS assembly ATPase SufC GSY65_RS08155 ENOG4105JRK feS assembly protein SufD GSY65_RS08180 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GSY65_RS08200 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GSY65_RS08210 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GSY65_RS08225 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GSY65_RS08240 ENOG4107QP8 phosphohexose isomerase GSY65_RS08255 ENOG4105CP7 Triose-phosphate isomerase GSY65_RS08260 ENOG4105BZA Phosphoglycerate kinase GSY65_RS08265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GSY65_RS08275 ENOG4105CIE May be required for sporulation (By similarity) GSY65_RS08280 ENOG4105CHW UPF0052 protein GSY65_RS08285 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GSY65_RS08290 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GSY65_RS08295 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS08300 ENOG4105BZU Histidine kinase GSY65_RS08315 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GSY65_RS08330 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GSY65_RS08345 ENOG4107R0W ABC transporter GSY65_RS08350 ENOG4105E5Q amino acid AbC transporter GSY65_RS08355 ENOG4105CDA abc transporter atp-binding protein GSY65_RS08360 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GSY65_RS08365 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GSY65_RS08370 ENOG4105CSH Transporter GSY65_RS08395 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GSY65_RS08400 ENOG4105BZU Histidine kinase GSY65_RS08405 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GSY65_RS08410 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GSY65_RS08420 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GSY65_RS08425 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GSY65_RS08430 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GSY65_RS08435 ENOG4105D7N magnesium and cobalt transport protein CorA GSY65_RS08465 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GSY65_RS08470 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GSY65_RS08500 ENOG4105BZ1 (ABC) transporter GSY65_RS08580 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GSY65_RS08590 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GSY65_RS08600 ENOG4105CQ7 ATP-dependent helicase GSY65_RS08635 ENOG4105KA0 thioesterase Superfamily protein GSY65_RS08655 ENOG4105C32 Amino acid ABC transporter (Permease) GSY65_RS08660 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GSY65_RS08665 ENOG4105C0Z ABC transporter GSY65_RS08670 ENOG4108IV0 ABC, transporter GSY65_RS08690 ENOG4105CA9 Pyruvate kinase GSY65_RS08700 ENOG4105CGH 5'-nucleotidase GSY65_RS08720 ENOG4108ZXC Two component transcriptional regulator, luxr family GSY65_RS08725 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GSY65_RS08735 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GSY65_RS08760 ENOG4105EA8 2-Nitropropane dioxygenase GSY65_RS08765 ENOG4105F2C Acetyl-CoA acetyltransferase GSY65_RS08770 ENOG4108RZE Tetr family transcriptional regulator GSY65_RS08775 ENOG4105CHR reductase GSY65_RS08780 ENOG4105CC9 acyl-Coa dehydrogenase GSY65_RS08785 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS08790 ENOG4105MUA Resistance protein GSY65_RS08805 ENOG4105CBC glutamate synthase GSY65_RS08815 ENOG41065RQ ADP-ribosylation crystallin J1 GSY65_RS08835 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GSY65_RS08840 ENOG4105CI0 Citrate lyase GSY65_RS08845 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GSY65_RS08855 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GSY65_RS08860 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GSY65_RS08870 ENOG4105DK0 Indole-3-glycerol phosphate synthase GSY65_RS08895 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GSY65_RS08915 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GSY65_RS08920 ENOG4108176 endoribonuclease L-psp GSY65_RS08925 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GSY65_RS08930 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GSY65_RS08935 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GSY65_RS08940 ENOG4105CIH Imidazole acetol-phosphate transaminase GSY65_RS08965 ENOG4108Z66 YbaK ebsC protein GSY65_RS08990 ENOG4105C0B DNA polymerase III (alpha subunit) GSY65_RS09045 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GSY65_RS09050 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GSY65_RS09055 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GSY65_RS09060 ENOG4107VQS DivIVA family GSY65_RS09070 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GSY65_RS09075 ENOG4105DFA alanine racemase domain protein GSY65_RS09080 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GSY65_RS09085 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GSY65_RS09090 ENOG4105ME9 cell division protein FtsQ GSY65_RS09095 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GSY65_RS09105 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GSY65_RS09110 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GSY65_RS09120 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GSY65_RS09125 ENOG4105CJN penicillin-binding protein GSY65_RS09135 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GSY65_RS09145 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GSY65_RS09165 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GSY65_RS09175 ENOG4105FDK ABC transporter GSY65_RS09185 ENOG4107Z3H Transcriptional regulator, TetR family GSY65_RS09190 ENOG4105EWK phytoene GSY65_RS09205 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GSY65_RS09235 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GSY65_RS09245 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GSY65_RS09255 ENOG4108UQY Iron-storage protein GSY65_RS09270 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GSY65_RS09285 ENOG4105CTQ phosphohexokinase GSY65_RS09295 ENOG4105ENE Histidine kinase GSY65_RS09320 ENOG4105DKQ ROK family GSY65_RS09330 ENOG4105D0U Arsenite-activated ATPase (ArsA) GSY65_RS09355 ENOG4105JNK Glycosyl transferase (Group 1 GSY65_RS09410 ENOG4108I0Q anthranilate phosphoribosyltransferase GSY65_RS09415 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GSY65_RS09420 ENOG4107EUI c reductase, iron-sulfur GSY65_RS09425 ENOG4107UDY cytochrome C GSY65_RS09430 ENOG4105CCU oxidase (Subunit III) GSY65_RS09445 ENOG4105MCD Part of cytochrome c oxidase, its function is GSY65_RS09450 ENOG4105BZ9 Cytochrome C oxidase, subunit I GSY65_RS09455 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GSY65_RS09460 ENOG4105C3J Cysteine desulfurase GSY65_RS09490 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GSY65_RS09505 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS09510 ENOG4105BZU Histidine kinase GSY65_RS09530 ENOG4105DXX methyltransferase GSY65_RS09540 ENOG4108YZT Adenosylcobinamide kinase GSY65_RS09550 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GSY65_RS09555 ENOG4105CRK lysyL-tRNA synthetase GSY65_RS09570 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GSY65_RS09580 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GSY65_RS09600 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GSY65_RS09650 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GSY65_RS09655 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GSY65_RS09675 ENOG4105C5F glutamine synthetase GSY65_RS09685 ENOG4105C57 major facilitator superfamily GSY65_RS09705 ENOG4107SCK Monooxygenase GSY65_RS09715 ENOG4105D0M Protease HtpX homolog GSY65_RS09745 ENOG4108222 arsenate reductase GSY65_RS09750 ENOG4106SPC secreted protein GSY65_RS09755 ENOG4107R5B glutamine synthetase GSY65_RS09765 ENOG4107NHD transcriptional regulator GSY65_RS09795 ENOG41060BG Tetr family transcriptional regulator GSY65_RS09820 ENOG4105CG3 alpha amylase, catalytic region GSY65_RS09825 ENOG4105EG2 ABC transporter, permease GSY65_RS09830 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component GSY65_RS09840 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS09850 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GSY65_RS09855 ENOG4105C5F glutamine synthetase GSY65_RS09875 ENOG4105F27 Major Facilitator GSY65_RS09890 ENOG4105C57 major facilitator superfamily GSY65_RS09895 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GSY65_RS09915 ENOG4107XZ0 Peptidase M50 GSY65_RS09945 ENOG4105BZU Histidine kinase GSY65_RS09970 ENOG410650H (LipO)protein GSY65_RS09975 ENOG4105DBE peroxidase GSY65_RS09985 ENOG4106A0S GSY65_RS10010 ENOG4107S1E Beta-lactamase GSY65_RS10015 ENOG4105C2C drug resistance transporter, Bcr CflA GSY65_RS10025 ENOG4105DGI Alkaline phosphatase GSY65_RS10035 ENOG4105CPC Aldo Keto reductase GSY65_RS10045 ENOG4108VGI doxx family GSY65_RS10055 ENOG4105EYF MMPL domain protein GSY65_RS10060 ENOG4105BZU Histidine kinase GSY65_RS10065 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS10070 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GSY65_RS10075 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GSY65_RS10085 ENOG4107QRT dEAD DEAH box helicase GSY65_RS10240 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GSY65_RS10250 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GSY65_RS10265 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GSY65_RS10270 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GSY65_RS10280 ENOG4105CAQ asparagine synthetase GSY65_RS10285 ENOG4105EBR Carboxylesterase GSY65_RS10290 ENOG4107QZF nitrite reductase NADPH large subunit GSY65_RS10295 ENOG4107QZF nitrite reductase NADPH large subunit GSY65_RS10300 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GSY65_RS10305 ENOG4107QND Nitrite extrusion protein GSY65_RS10320 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GSY65_RS10330 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GSY65_RS10380 ENOG4107XFJ UPF0246 protein GSY65_RS10385 ENOG4105CVJ phosphoglycerate mutase GSY65_RS10395 ENOG4105EGD dinuclear metal center protein, YbgI family GSY65_RS10405 ENOG4105CHR reductase GSY65_RS10420 ENOG4105C0R drug resistance transporter emrb qaca subfamily GSY65_RS10435 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GSY65_RS10445 ENOG4105DYW oxidoreductase GSY65_RS10460 ENOG4107QVI Methyltransferase, type 11 GSY65_RS10465 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GSY65_RS10470 ENOG4108SGK Tetr family transcriptional regulator GSY65_RS10510 ENOG4108JJB ABC transporter GSY65_RS10545 ENOG4105F2C Acetyl-CoA acetyltransferase GSY65_RS10555 ENOG4106A3M Cytochrome p-450 GSY65_RS10695 ENOG4108JQC penicillin-binding protein 1A GSY65_RS10705 ENOG4107T5V SNARE associated Golgi GSY65_RS10715 ENOG4105DAX Pfam:DUF2983 GSY65_RS10760 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GSY65_RS10765 ENOG4105EYW Ion transport protein GSY65_RS10795 ENOG4105CPC Aldo Keto reductase GSY65_RS10800 ENOG4105VUF Transcriptional regulator GSY65_RS10835 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GSY65_RS10840 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GSY65_RS10860 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GSY65_RS10865 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GSY65_RS10875 ENOG4105NGS secreted protein GSY65_RS10880 ENOG4105EXN Sulfate transport protein CysZ GSY65_RS10895 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GSY65_RS10905 ENOG41062B0 ABC transporter, permease GSY65_RS10910 ENOG4107R9N ABC transporter GSY65_RS10915 ENOG4105C2J ABC transporter GSY65_RS10920 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GSY65_RS10925 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS10940 ENOG4105CXK mandelate racemase muconate lactonizing GSY65_RS10960 ENOG4105C2J ABC transporter GSY65_RS10965 ENOG4108HWW ABC transporter GSY65_RS10970 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GSY65_RS10975 ENOG4105CIH Imidazole acetol-phosphate transaminase GSY65_RS11010 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GSY65_RS11015 ENOG4107HP6 Transcriptional regulator GSY65_RS11050 ENOG41073B4 coagulation factor 5 8 type domain-containing protein GSY65_RS11070 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GSY65_RS11110 ENOG4105C6F GntR Family Transcriptional Regulator GSY65_RS11115 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS11120 ENOG4105D8K carboxyl transferase GSY65_RS11170 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein GSY65_RS11180 ENOG4105C57 major facilitator superfamily GSY65_RS11190 ENOG4107RBS Methyltransferase GSY65_RS11195 ENOG4107S5I aldo keto reductase GSY65_RS11200 ENOG4107RSM transcriptional regulator GSY65_RS11215 ENOG4107R13 MMPL domain protein GSY65_RS11240 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GSY65_RS11245 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GSY65_RS11250 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS11260 ENOG4106UW1 Major Facilitator superfamily GSY65_RS11295 ENOG4108ZGX Histidine kinase GSY65_RS11315 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GSY65_RS11320 ENOG4107R13 MMPL domain protein GSY65_RS11330 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GSY65_RS11335 ENOG4105DQU oxidoreductase, subunit beta GSY65_RS11340 ENOG4108Z4U Ferredoxin GSY65_RS11375 ENOG4107QSN dihydrolipoamide acetyltransferase GSY65_RS11390 ENOG4108JA1 polyketide synthase GSY65_RS11410 ENOG4107RCI amp-dependent synthetase and ligase GSY65_RS11430 ENOG4105C8Y Acetylornithine aminotransferase GSY65_RS11445 ENOG4105C3U ABC transporter GSY65_RS11455 ENOG4105DV0 amidase (EC 3.5.1.4 GSY65_RS11495 ENOG4108HMN Caspase domain GSY65_RS11575 ENOG4105FA0 parb-like partition protein GSY65_RS11680 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS11685 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GSY65_RS11695 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GSY65_RS11705 ENOG4107GZ4 SanA protein GSY65_RS11720 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GSY65_RS11735 ENOG4108PJD permease GSY65_RS11765 ENOG4107QZF nitrite reductase NADPH large subunit GSY65_RS11775 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GSY65_RS11800 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GSY65_RS11805 ENOG4105E2R ROK family GSY65_RS11840 ENOG4108J20 pectate lyase GSY65_RS11870 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GSY65_RS11880 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GSY65_RS11885 ENOG4105DSE periplasmic solute binding protein GSY65_RS11890 ENOG4105FDK ABC transporter GSY65_RS11895 ENOG4105FAV ABC, transporter GSY65_RS11910 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GSY65_RS11915 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GSY65_RS11940 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GSY65_RS11950 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GSY65_RS11955 ENOG4105D4Y metalloprotease GSY65_RS11980 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GSY65_RS12005 ENOG4105MSB protein, conserved in bacteria GSY65_RS12015 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GSY65_RS12025 ENOG4107HP6 Transcriptional regulator GSY65_RS12030 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GSY65_RS12035 ENOG4105EQX glucarate dehydratase GSY65_RS12055 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GSY65_RS12060 ENOG4107YU2 histidine triad (hIT) protein GSY65_RS12065 ENOG4107RE3 peptidase, S41 GSY65_RS12080 ENOG4107QWG 2-Nitropropane dioxygenase GSY65_RS12085 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GSY65_RS12090 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GSY65_RS12135 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GSY65_RS12145 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GSY65_RS12150 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GSY65_RS12165 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GSY65_RS12175 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GSY65_RS12180 ENOG4105EPR degv family GSY65_RS12190 ENOG4105C8T Leucyl-tRNA synthetase GSY65_RS12200 ENOG4107QIZ NADH dehydrogenase GSY65_RS12220 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GSY65_RS12235 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GSY65_RS12240 ENOG4105D0M Protease HtpX homolog GSY65_RS12255 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GSY65_RS12265 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GSY65_RS12275 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GSY65_RS12280 ENOG4105K46 50S ribosomal protein l27 GSY65_RS12285 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GSY65_RS12295 ENOG4105C03 ribonuclease GSY65_RS12330 ENOG4105CNI cell division protein FtsW GSY65_RS12335 ENOG4105CJN penicillin-binding protein GSY65_RS12350 ENOG4105DFF Rod shape-determining protein mreb GSY65_RS12355 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GSY65_RS12365 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GSY65_RS12370 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GSY65_RS12385 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GSY65_RS12390 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GSY65_RS12395 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GSY65_RS12400 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GSY65_RS12420 ENOG4108TGC Acyltransferase GSY65_RS12460 ENOG4105C85 amino acid GSY65_RS12475 ENOG4105C85 amino acid GSY65_RS12490 ENOG4105MC2 DSBA oxidoreductase GSY65_RS12560 ENOG4108ZT1 Transcriptional regulator GSY65_RS12585 ENOG4105D8X mechanosensitive ion channel GSY65_RS12610 ENOG4105F8D glycoside hydrolase family 4 GSY65_RS12625 ENOG4105CT1 (ABC) transporter GSY65_RS12640 ENOG4108ZF3 Phosphatase GSY65_RS12655 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GSY65_RS12685 ENOG4105VHU single-stranded DNA-binding protein GSY65_RS12690 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GSY65_RS12705 ENOG4108JQ1 Dehydrogenase GSY65_RS12770 ENOG4105D3Q Sugar transferase GSY65_RS12780 ENOG4105CJR Integral membrane protein (MviN GSY65_RS12815 ENOG4105C3M thioredoxin reductase GSY65_RS12820 ENOG4105S2J secreted protein GSY65_RS12860 ENOG4105CJ1 ABC, transporter GSY65_RS12865 ENOG4105C26 Dehydrogenase GSY65_RS12870 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GSY65_RS12875 ENOG4105DH8 myo-inositol catabolism GSY65_RS12885 ENOG4105EDK PfkB domain protein GSY65_RS12890 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GSY65_RS12910 ENOG4107R13 MMPL domain protein GSY65_RS12935 ENOG4105C7H Helicase, RecD TraA family GSY65_RS12955 ENOG4108PSK reductase GSY65_RS12965 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS12970 ENOG4105C2J ABC transporter GSY65_RS12975 ENOG4105CNN ABC, transporter GSY65_RS12980 ENOG4108RVA ribokinase GSY65_RS12985 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GSY65_RS13030 ENOG4105EC2 ftsk spoIIIe GSY65_RS13040 ENOG410905P Pyridoxamine 5-phosphate GSY65_RS13045 ENOG4105C4Y ABC transporter GSY65_RS13055 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GSY65_RS13110 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS13125 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GSY65_RS13145 ENOG4105EC3 peptidase S51, dipeptidase E GSY65_RS13150 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GSY65_RS13155 ENOG4105D17 glycoside hydrolase, family 3 domain protein GSY65_RS13200 ENOG4105CJ1 ABC, transporter GSY65_RS13215 ENOG4105EEM helicase GSY65_RS13230 ENOG4105NPE arsR family transcriptional regulator GSY65_RS13235 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GSY65_RS13260 ENOG4108K8S endonuclease I GSY65_RS13270 ENOG4105C7K acetolactate synthase GSY65_RS13285 ENOG4108XFF GSY65_RS13290 ENOG4105C29 acyl-CoA thioesterase GSY65_RS13305 ENOG4107QX3 carboxylase GSY65_RS13315 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GSY65_RS13320 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS13335 ENOG4105DY8 decarboxylase GSY65_RS13340 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GSY65_RS13350 ENOG4105DUU IucA IucC family protein GSY65_RS13365 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GSY65_RS13380 ENOG4105ECQ AraC Family Transcriptional Regulator GSY65_RS13385 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GSY65_RS13395 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS13400 ENOG4105XN3 extracellular solute-binding protein family 1 GSY65_RS13410 ENOG4105DRS transport system, permease GSY65_RS13435 ENOG4105I1K ABC transporter GSY65_RS13445 ENOG4105EPJ extracellular solute-binding protein family 1 GSY65_RS13465 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GSY65_RS13480 ENOG4105CVJ phosphoglycerate mutase GSY65_RS13505 ENOG4105DU1 integral membrane protein, terc GSY65_RS13545 ENOG4105BZU Histidine kinase GSY65_RS13550 ENOG4105DEN Luciferase family GSY65_RS13610 ENOG4108M1A Chitin-binding protein GSY65_RS13640 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GSY65_RS13665 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) GSY65_RS13670 ENOG4105D9R oxidoreductase GSY65_RS13680 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GSY65_RS13690 ENOG4108U4N (sortase) family GSY65_RS13745 ENOG41087EV Hsp20/alpha crystallin family GSY65_RS13765 ENOG4106BRA Membrane GSY65_RS13795 ENOG4108JQC penicillin-binding protein 1A GSY65_RS13830 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GSY65_RS13840 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GSY65_RS13845 ENOG4105CI1 PTS System GSY65_RS13870 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GSY65_RS13880 ENOG4108RQ5 Beta-lactamase domain-containing protein GSY65_RS13905 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS13915 ENOG4105C85 amino acid GSY65_RS13925 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GSY65_RS13935 ENOG4108RWI nicotinamidase GSY65_RS13945 ENOG4107G87 m6 family metalloprotease domain protein GSY65_RS13965 ENOG4105KF0 sporulation and cell division protein, SsgA GSY65_RS13970 ENOG4105CQB FAD linked oxidase domain protein GSY65_RS13980 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GSY65_RS13990 ENOG4105E90 ABC transporter GSY65_RS13995 ENOG4108IJ8 ABC transporter GSY65_RS14000 ENOG4105E90 ABC transporter GSY65_RS14015 ENOG4108NJC GSY65_RS14045 ENOG41086VY Fic/DOC family GSY65_RS14070 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GSY65_RS14085 ENOG4105E2D ec 3.2.1.52 GSY65_RS14110 ENOG4108UJU UPF0301 protein GSY65_RS14115 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GSY65_RS14120 ENOG4108426 dNA-binding protein GSY65_RS14130 ENOG4105EEM helicase GSY65_RS14155 ENOG4105DQQ Major facilitator superfamily MFS_1 GSY65_RS14160 ENOG4108IG5 Transcriptional regulator GSY65_RS14170 ENOG41064MX Tetr family transcriptional regulator GSY65_RS14205 ENOG4106NZI LysR family Transcriptional regulator GSY65_RS14220 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GSY65_RS14225 ENOG4105I1K ABC transporter GSY65_RS14230 ENOG4105CJQ hydrolase, family 31 GSY65_RS14235 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS14245 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GSY65_RS14250 ENOG4105CN1 protease GSY65_RS14260 ENOG4105CAK Cell division ATP-binding protein ftsE GSY65_RS14275 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GSY65_RS14280 ENOG4108QVN serine threonine protein kinase GSY65_RS14290 ENOG4108UGD Serine Threonine protein kinase GSY65_RS14295 ENOG4105EC2 ftsk spoIIIe GSY65_RS14300 ENOG4105EPJ extracellular solute-binding protein family 1 GSY65_RS14305 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component GSY65_RS14310 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GSY65_RS14315 ENOG4107SJB teichoic acid biosynthesis GSY65_RS14320 ENOG4105K64 Glycosyl transferase, family 2 GSY65_RS14330 ENOG4108ZHJ Organic hydroperoxide resistance protein GSY65_RS14335 ENOG4105K56 Transcriptional regulator GSY65_RS14340 ENOG4105K64 Glycosyl transferase, family 2 GSY65_RS14345 ENOG4105CMR udp-glucose 4-epimerase GSY65_RS14385 ENOG4105EY8 ABC transporter GSY65_RS14390 ENOG4105CG5 Glycosyl transferase (Group 1 GSY65_RS14395 ENOG4107SJB teichoic acid biosynthesis GSY65_RS14400 ENOG4108762 serine threonine protein kinase GSY65_RS14410 ENOG4105C7I Dehydrogenase GSY65_RS14430 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GSY65_RS14440 ENOG4105T0Z Conserved Protein GSY65_RS14445 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS14450 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GSY65_RS14460 ENOG4105G3P Lipoprotein lpqB GSY65_RS14465 ENOG4105BZU Histidine kinase GSY65_RS14470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS14475 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GSY65_RS14490 ENOG4108WQ6 secreted protein GSY65_RS14495 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GSY65_RS14535 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GSY65_RS14545 ENOG4105EIP mannose-6-phosphate isomerase GSY65_RS14555 ENOG4105W49 UPF0434 protein GSY65_RS14560 ENOG4107QKV phosphomannomutase GSY65_RS14580 ENOG4107RGC Glycosyl transferase, family 2 GSY65_RS14585 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GSY65_RS14595 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase GSY65_RS14600 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) GSY65_RS14610 ENOG4108S0S Nucleotidyl transferase GSY65_RS14625 ENOG4108KGH TRANSCRIPTIONal GSY65_RS14630 ENOG4107TB5 TRANSCRIPTIONal GSY65_RS14635 ENOG4108KGH TRANSCRIPTIONal GSY65_RS14645 ENOG4108KGH TRANSCRIPTIONal GSY65_RS14655 ENOG4108KGH TRANSCRIPTIONal GSY65_RS14670 ENOG4105C6Y Udp-glucose 6-dehydrogenase GSY65_RS14695 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GSY65_RS14710 ENOG41065SU Two-component system sensor kinase GSY65_RS14715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS14720 ENOG4105DUX Transporter GSY65_RS14745 ENOG41082AN stage II sporulation protein GSY65_RS14750 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS14755 ENOG4105CI2 imidazolone-5-propionate hydrolase GSY65_RS14770 ENOG4105CGP Urocanate hydratase GSY65_RS14835 ENOG4105CHU acetyl-coa acetyltransferase GSY65_RS14865 ENOG4108YYH Nadph-dependent fmn reductase GSY65_RS14880 ENOG4105F0K SARP family transcriptional regulator GSY65_RS14900 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) GSY65_RS14905 ENOG4105D8K carboxyl transferase GSY65_RS14935 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GSY65_RS14975 ENOG4105CB2 alcohol dehydrogenase GSY65_RS14980 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GSY65_RS14985 ENOG4105C0R drug resistance transporter emrb qaca subfamily GSY65_RS14990 ENOG4107STQ Multicopper oxidase GSY65_RS15000 ENOG4105EMU Dehydrogenase GSY65_RS15025 ENOG4108VTW Thioesterase GSY65_RS15060 ENOG4105CAQ asparagine synthetase GSY65_RS15070 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS15080 ENOG4105MXW flavin reductase domain protein, FMN-binding GSY65_RS15095 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS15100 ENOG4107RBB ABC transporter, permease GSY65_RS15105 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GSY65_RS15110 ENOG4105CEP NADH dehydrogenase GSY65_RS15140 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GSY65_RS15155 ENOG4106A3M Cytochrome p-450 GSY65_RS15225 ENOG4107RBB ABC transporter, permease GSY65_RS15230 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS15235 ENOG4105C0R drug resistance transporter emrb qaca subfamily GSY65_RS15245 ENOG4107QN1 sodium solute GSY65_RS15290 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GSY65_RS15295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GSY65_RS15300 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GSY65_RS15305 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GSY65_RS15315 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GSY65_RS15325 ENOG41067SE Tetr family transcriptional regulator GSY65_RS15335 ENOG4105CSH Transporter GSY65_RS15340 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GSY65_RS15345 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GSY65_RS15350 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS15385 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GSY65_RS15430 ENOG4105C5H ABC transporter GSY65_RS15440 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GSY65_RS15450 ENOG41069ER domain protein GSY65_RS15455 ENOG4105F8V Hydrolase, tatD family GSY65_RS15510 ENOG4108ZHJ Organic hydroperoxide resistance protein GSY65_RS15515 ENOG4105K56 Transcriptional regulator GSY65_RS15520 ENOG4108JJB ABC transporter GSY65_RS15530 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GSY65_RS15550 ENOG4108WZA zeta toxin GSY65_RS15560 ENOG4105EYF MMPL domain protein GSY65_RS15580 ENOG4105CHR reductase GSY65_RS15585 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GSY65_RS15590 ENOG4105F95 Monooxygenase GSY65_RS15600 ENOG4105CGK Exodeoxyribonuclease III GSY65_RS15630 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GSY65_RS15635 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GSY65_RS15645 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GSY65_RS15650 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GSY65_RS15660 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GSY65_RS15675 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GSY65_RS15685 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GSY65_RS15720 ENOG4105DM4 PTS System GSY65_RS15725 ENOG4105DE4 1-phosphofructokinase GSY65_RS15750 ENOG4108Z7F N-acetyltransferase GSY65_RS15755 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GSY65_RS15780 ENOG4107HP6 Transcriptional regulator GSY65_RS15795 ENOG4108IUW ABC transporter GSY65_RS15815 ENOG4105D5G Transposase GSY65_RS15885 ENOG4108V06 Glutathione peroxidase GSY65_RS15900 ENOG4105DZ1 carboxypeptidase GSY65_RS15960 ENOG4106F59 XRE family Transcriptional regulator GSY65_RS15975 ENOG41073TP transcriptional regulator GSY65_RS16010 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GSY65_RS16035 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GSY65_RS16040 ENOG4107G87 m6 family metalloprotease domain protein GSY65_RS16065 ENOG4105DXX methyltransferase GSY65_RS16110 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS16135 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS16185 ENOG4108762 serine threonine protein kinase GSY65_RS16195 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GSY65_RS16205 ENOG4105D2B acyl-CoA dehydrogenase GSY65_RS16245 ENOG4105H3G oxidoreductase GSY65_RS16255 ENOG4105CGU Enoyl-CoA hydratase GSY65_RS16270 ENOG4105D2S major facilitator superfamily GSY65_RS16290 ENOG4105CC9 acyl-Coa dehydrogenase GSY65_RS16295 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GSY65_RS16310 ENOG4105D2B acyl-CoA dehydrogenase GSY65_RS16315 ENOG4105CC9 acyl-Coa dehydrogenase GSY65_RS16325 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS16335 ENOG4105WN5 stage II sporulation protein GSY65_RS16385 ENOG4108XEP Alpha Beta Hydrolase Fold protein GSY65_RS16395 ENOG4108SU4 UPF0309 protein GSY65_RS16425 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GSY65_RS16435 ENOG4105CGU Enoyl-CoA hydratase GSY65_RS16440 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS16455 ENOG4107QX3 carboxylase GSY65_RS16480 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS16485 ENOG4105ENE Histidine kinase GSY65_RS16495 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS16500 ENOG4105CQB FAD linked oxidase domain protein GSY65_RS16520 ENOG4106A3M Cytochrome p-450 GSY65_RS16525 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GSY65_RS16535 ENOG4106R7G Glycoside hydrolase family 5 GSY65_RS16560 ENOG4105CPC Aldo Keto reductase GSY65_RS16605 ENOG4105C7N Xanthine uracil vitamin C permease GSY65_RS16615 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GSY65_RS16650 ENOG4108N0W Major Facilitator superfamily GSY65_RS16660 ENOG4108UIH futalosine nucleosidase GSY65_RS16665 ENOG4105E63 Pfam:DUF178 GSY65_RS16670 ENOG4105VEQ Cold shock protein GSY65_RS16705 ENOG4108TEB UPF0114 protein GSY65_RS16710 ENOG4105CFI type iii restriction protein res subunit GSY65_RS16720 ENOG4105EEM helicase GSY65_RS16740 ENOG4106N3A copper homeostasis protein cutc GSY65_RS16770 ENOG4105KVH Transcriptional regulator GSY65_RS16790 ENOG4105QEK Transcriptional regulator GSY65_RS16795 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GSY65_RS16825 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GSY65_RS16845 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GSY65_RS16850 ENOG4105VEQ Cold shock protein GSY65_RS16865 ENOG4105C3Q Glycosyl transferase, family 2 GSY65_RS16885 ENOG4105XN3 extracellular solute-binding protein family 1 GSY65_RS16895 ENOG4105CE4 GlcNAc 6-P deacetylase GSY65_RS16900 ENOG4105DE4 1-phosphofructokinase GSY65_RS16910 ENOG4105BZU Histidine kinase GSY65_RS16920 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GSY65_RS16965 ENOG4107SMB hydrolase Family 5 GSY65_RS17020 ENOG4108IJ9 (ABC) transporter GSY65_RS17040 ENOG4105C2N RNA methyltransferase TrmH family group 3 GSY65_RS17045 ENOG4105C8N cysteinyl-tRNA synthetase GSY65_RS17050 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GSY65_RS17055 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GSY65_RS17060 ENOG4108VJ1 Transcriptional regulator (CarD family GSY65_RS17080 ENOG4105BZU Histidine kinase GSY65_RS17095 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GSY65_RS17110 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GSY65_RS17165 ENOG4108XFH Transcriptional regulator GSY65_RS17180 ENOG4105FDP GntR family transcriptional regulator GSY65_RS17190 ENOG4105FDP GntR family transcriptional regulator GSY65_RS17195 ENOG4105HHS UPF0256 protein GSY65_RS17210 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GSY65_RS17215 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GSY65_RS17225 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GSY65_RS17245 ENOG4105PKJ carbohydrate binding GSY65_RS17250 ENOG4105KHC sulfurtransferase GSY65_RS17275 ENOG4107NHD transcriptional regulator GSY65_RS17280 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS17285 ENOG4105C0H protease GSY65_RS17295 ENOG4105ETX regulatoR GSY65_RS17305 ENOG41086D8 Transcriptional regulator GSY65_RS17310 ENOG4105CGH 5'-nucleotidase GSY65_RS17315 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GSY65_RS17320 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GSY65_RS17340 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GSY65_RS17360 ENOG4105VPX protein, conserved in bacteria GSY65_RS17370 ENOG4105CJ3 phosphate transporter GSY65_RS17375 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GSY65_RS17395 ENOG4105DNP FAD linked oxidase domain protein GSY65_RS17400 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GSY65_RS17405 ENOG4105E4C Lytic transglycosylase catalytic GSY65_RS17520 ENOG4105D5U fad dependent oxidoreductase GSY65_RS17525 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GSY65_RS17550 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GSY65_RS17600 ENOG4105C1J atp-dependent rna helicase GSY65_RS17635 ENOG4105CQ7 ATP-dependent helicase GSY65_RS17655 ENOG4108TAC GSY65_RS17660 ENOG4107RDP Dehydrogenase GSY65_RS17670 ENOG4105CXB phosphoribosylaminoimidazole synthetase GSY65_RS17690 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GSY65_RS17695 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GSY65_RS17700 ENOG410839H phosphoribosylformylglycinamidine synthase GSY65_RS17745 ENOG4105C8V SAICAR synthetase GSY65_RS17760 ENOG4105C12 Phosphoribosylglycinamide synthetase GSY65_RS17785 ENOG4108HH4 Major Facilitator Superfamily GSY65_RS17795 ENOG4105NCW Trka-c domain protein GSY65_RS17825 ENOG4108T5E Copper resistance protein GSY65_RS17870 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GSY65_RS17885 ENOG4108Z6B deaminase GSY65_RS17895 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein GSY65_RS17900 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS17910 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS17920 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GSY65_RS17930 ENOG4108YYC ycei family GSY65_RS17935 ENOG410905P Pyridoxamine 5-phosphate GSY65_RS17945 ENOG4105C57 major facilitator superfamily GSY65_RS17950 ENOG4105EDW glycosyl transferase, family 39 GSY65_RS17960 ENOG4105BZU Histidine kinase GSY65_RS17965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS17970 ENOG4105KAC Antibiotic biosynthesis monooxygenase GSY65_RS18010 ENOG4108UXN response regulator GSY65_RS18015 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS18020 ENOG4105NAF rna polymerase sigma factor GSY65_RS18095 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GSY65_RS18115 ENOG4107T6F Xaa-Pro aminopeptidase GSY65_RS18120 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GSY65_RS18160 ENOG4105DBE peroxidase GSY65_RS18170 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GSY65_RS18175 ENOG410667J hydrolase GSY65_RS18195 ENOG4105CIG ABC transporter GSY65_RS18225 ENOG4107SWG transcriptional regulator MERR family GSY65_RS18230 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) GSY65_RS18240 ENOG410667J hydrolase GSY65_RS18245 ENOG4105E4C Lytic transglycosylase catalytic GSY65_RS18250 ENOG4108JJ9 ABC, transporter GSY65_RS18255 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GSY65_RS18260 ENOG4105C4M (Ubiquinol oxidase) subunit I GSY65_RS18265 ENOG4105CIH Imidazole acetol-phosphate transaminase GSY65_RS18270 ENOG4107P2S Transcriptional regulator GSY65_RS18275 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GSY65_RS18285 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GSY65_RS18310 ENOG4106048 Cupin 2, conserved barrel domain protein GSY65_RS18315 ENOG41082T9 Membrane GSY65_RS18320 ENOG4105KJF protein tyrosine phosphatase GSY65_RS18325 ENOG4105C28 cystathionine GSY65_RS18355 ENOG4105F27 Major Facilitator GSY65_RS18360 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) GSY65_RS18365 ENOG410870W N-acetyltransferase GSY65_RS18375 ENOG4105CDU Replicative dna helicase GSY65_RS18390 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GSY65_RS18395 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GSY65_RS18400 ENOG4107YH6 single-stranded DNA-binding protein GSY65_RS18405 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GSY65_RS18430 ENOG4105BZ4 penicillin-binding protein GSY65_RS18440 ENOG4105CZA synthase GSY65_RS18450 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GSY65_RS18465 ENOG4105D9P serine threonine protein kinase GSY65_RS18480 ENOG4105C3M thioredoxin reductase GSY65_RS18485 ENOG4105K63 Thioredoxin GSY65_RS18500 ENOG4107QJE Chromosome Partitioning Protein GSY65_RS18505 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GSY65_RS18515 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GSY65_RS18520 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GSY65_RS18525 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GSY65_RS18530 ENOG41084CH 50S ribosomal protein l34 GSY65_RS18535 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GSY65_RS18540 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GSY65_RS18545 ENOG4108J5G 6-phosphogluconate dehydrogenase GSY65_RS18550 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GSY65_RS18555 ENOG4105K7N UPF0232 protein GSY65_RS18560 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GSY65_RS18565 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GSY65_RS18595 ENOG4108UGD Serine Threonine protein kinase GSY65_RS18625 ENOG4105ZJT Cell division protein CrgA GSY65_RS18635 ENOG4108U4N (sortase) family GSY65_RS18650 ENOG4108U4N (sortase) family GSY65_RS18655 ENOG4108RN7 integral membrane protein GSY65_RS18680 ENOG4105HZM Fha domain containing protein GSY65_RS18685 ENOG4105TV9 FHA Domain-Containing protein GSY65_RS18705 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GSY65_RS18710 ENOG4105KVH Transcriptional regulator GSY65_RS18745 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GSY65_RS18755 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GSY65_RS18760 ENOG4108IG5 Transcriptional regulator GSY65_RS18780 ENOG4107QSN dihydrolipoamide acetyltransferase GSY65_RS18785 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GSY65_RS18790 ENOG4105CVM Molybdenum cofactor synthesis domain protein GSY65_RS18795 ENOG4105EYW Ion transport protein GSY65_RS18825 ENOG4107QPV Serine Threonine protein kinase GSY65_RS18840 ENOG4105CPP Dehydrogenase, E1 component GSY65_RS18845 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GSY65_RS18865 ENOG4105DJB Major Facilitator Superfamily GSY65_RS18900 ENOG4105C0X amino acid GSY65_RS18925 ENOG4105DFM M18 family aminopeptidase GSY65_RS18930 ENOG4105CSU acyl-Coa dehydrogenase GSY65_RS18940 ENOG4105EUB pirin domain protein GSY65_RS18955 ENOG4105C9M aspartyl-trna synthetase GSY65_RS19015 ENOG4108J20 pectate lyase GSY65_RS19025 ENOG4105KWG Pfam:DUF1696 GSY65_RS19030 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GSY65_RS19050 ENOG410613R integral membrane protein, YccS YhfK family GSY65_RS19065 ENOG4105F2Z 3-oxoadipate enol-lactonase GSY65_RS19070 ENOG4107SQD Transcriptional regulator, GntR family GSY65_RS19100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS19135 ENOG4105EMN RNA polymerase sigma factor GSY65_RS19155 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GSY65_RS19175 ENOG4108ZXC Two component transcriptional regulator, luxr family GSY65_RS19320 ENOG4105KVH Transcriptional regulator GSY65_RS19325 ENOG4105CDH Citrulline--aspartate ligase GSY65_RS19370 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase GSY65_RS19375 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GSY65_RS19385 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS19425 ENOG4105C0F tryptophanase EC 4.1.99.1 GSY65_RS19445 ENOG4105CJ1 ABC, transporter GSY65_RS19465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GSY65_RS19475 ENOG4108KPJ rna polymerase sigma factor GSY65_RS19490 ENOG4105C1J atp-dependent rna helicase GSY65_RS19495 ENOG4105VEQ Cold shock protein GSY65_RS19515 ENOG4108ZJ4 polysaccharide deacetylase GSY65_RS19535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS19540 ENOG4105BZU Histidine kinase GSY65_RS19545 ENOG4105I6B RNA polymerase GSY65_RS19560 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GSY65_RS19590 ENOG41082YX Transcriptional regulator, arsr family GSY65_RS19610 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase GSY65_RS19625 ENOG4107S2Z UPF0761 membrane protein GSY65_RS19655 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GSY65_RS19660 ENOG4105EMN RNA polymerase sigma factor GSY65_RS19685 ENOG4105DZ6 Band 7 protein GSY65_RS19695 ENOG4108Q50 Histidine kinase GSY65_RS19795 ENOG4105FDP GntR family transcriptional regulator GSY65_RS19805 ENOG4105CZE histidine utilization repressor GSY65_RS19870 ENOG4105DHP deoxycytidine triphosphate deaminase GSY65_RS19885 ENOG4105K6V RNA polymerase GSY65_RS19940 ENOG4105DF6 Fe-S oxidoreductase GSY65_RS19950 ENOG4105CFG Acts as a chaperone (By similarity) GSY65_RS19955 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GSY65_RS19960 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GSY65_RS19965 ENOG4105KNI merR family transcriptional Regulator GSY65_RS19985 ENOG4108S01 response regulator GSY65_RS20050 ENOG4105KVH Transcriptional regulator GSY65_RS20065 ENOG4105DFW ABC transporter GSY65_RS20100 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GSY65_RS20150 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GSY65_RS20170 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GSY65_RS20175 ENOG4107RCW fructose-bisphosphate aldolase GSY65_RS20190 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GSY65_RS20215 ENOG4105BZU Histidine kinase GSY65_RS20220 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS20235 ENOG4105DIM ABC transporter GSY65_RS20265 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GSY65_RS20275 ENOG4105CKK Glycosyl transferase, family 2 GSY65_RS20280 ENOG4108WYP Transcriptional regulator GSY65_RS20285 ENOG4108JPW Aminotransferase GSY65_RS20300 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GSY65_RS20305 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GSY65_RS20340 ENOG4105EB3 Histidine kinase GSY65_RS20350 ENOG4105CFH Aspartokinase GSY65_RS20360 ENOG4105NAF rna polymerase sigma factor GSY65_RS20400 ENOG41068HZ 50S ribosomal protein L32 GSY65_RS20405 ENOG4108PJD permease GSY65_RS20435 ENOG4108HMN Caspase domain GSY65_RS20440 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS20445 ENOG4105BZU Histidine kinase GSY65_RS20465 ENOG4107S91 Sodium hydrogen exchanger GSY65_RS20510 ENOG4105BZ4 penicillin-binding protein GSY65_RS20570 ENOG4105P8F nudix hydrolase GSY65_RS20585 ENOG4105D74 hydrolase GSY65_RS20595 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GSY65_RS20600 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GSY65_RS20605 ENOG4105CHH sulfate transporter GSY65_RS20665 ENOG4108I5C dEAD DEAH box helicase GSY65_RS20670 ENOG4105WN5 stage II sporulation protein GSY65_RS20675 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GSY65_RS20680 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GSY65_RS20705 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GSY65_RS20710 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GSY65_RS20715 ENOG4105C6E dna polymerase iii GSY65_RS20745 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GSY65_RS20770 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS20840 ENOG4105BZU Histidine kinase GSY65_RS20845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS20860 ENOG4105C19 ABC transporter GSY65_RS20865 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS20895 ENOG4106JDR secreted GSY65_RS20900 ENOG4105C0F tryptophanase EC 4.1.99.1 GSY65_RS20935 ENOG4105C2M dna polymerase I GSY65_RS20965 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GSY65_RS20970 ENOG4105KDC 50s ribosomal protein l28 GSY65_RS20980 ENOG4105NRA 50s ribosomal protein l31 type b GSY65_RS20990 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GSY65_RS21010 ENOG4105C26 Dehydrogenase GSY65_RS21035 ENOG4105CVK Glutamate decarboxylase GSY65_RS21040 ENOG4107TXC Transcriptional regulator GSY65_RS21055 ENOG4105F0N pyrophosphate phospho-hydrolase GSY65_RS21070 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GSY65_RS21075 ENOG4108UGV hypoxanthine phosphoribosyltransferase GSY65_RS21085 ENOG4105EUJ GTP cyclohydrolase i GSY65_RS21105 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GSY65_RS21115 ENOG4105CRK lysyL-tRNA synthetase GSY65_RS21140 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS21155 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS21160 ENOG41082SX arsR family transcriptional regulator GSY65_RS21175 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GSY65_RS21180 ENOG4108IYU L-aspartate oxidase GSY65_RS21190 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GSY65_RS21220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GSY65_RS21225 ENOG4105DR5 peptidase GSY65_RS21230 ENOG4108IG5 Transcriptional regulator GSY65_RS21240 ENOG4108FKE two-component system sensor kinase GSY65_RS21245 ENOG4108PYU two-component system response regulator GSY65_RS21250 ENOG41075QH Lipoprotein CseA GSY65_RS21255 ENOG4105NAF rna polymerase sigma factor GSY65_RS21275 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GSY65_RS21295 ENOG4108JWX GSY65_RS21300 ENOG4107R33 ppx gppa phosphatase GSY65_RS21305 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GSY65_RS21310 ENOG4105PF9 Transcriptional regulator GSY65_RS21315 ENOG4105C01 Dihydroxy-acid dehydratase GSY65_RS21325 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GSY65_RS21340 ENOG4105CJ1 ABC, transporter GSY65_RS21350 ENOG4105II7 pyrroline-5-carboxylate reductase GSY65_RS21355 ENOG4105C31 Tryptophanyl-tRNA synthetase GSY65_RS21385 ENOG4105DGU Histone deacetylase GSY65_RS21425 ENOG4108RXW HAD-superfamily subfamily IB hydrolase GSY65_RS21435 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GSY65_RS21440 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GSY65_RS21445 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GSY65_RS21450 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GSY65_RS21500 ENOG4107QTZ amino acid GSY65_RS21505 ENOG4105D52 delta-aminolevulinic acid dehydratase GSY65_RS21525 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GSY65_RS21535 ENOG4105C75 arginyL-tRNA synthetase GSY65_RS21540 ENOG4105DK7 lysyl-tRNA synthetase GSY65_RS21560 ENOG4105E0Y RtcB Protein GSY65_RS21575 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GSY65_RS21580 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GSY65_RS21585 ENOG4105ETX regulatoR GSY65_RS21590 ENOG41062D9 Histidine kinase GSY65_RS21615 ENOG4107SVH Potassium channel protein GSY65_RS21655 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GSY65_RS21660 ENOG4108RH7 phosphoglycerate mutase GSY65_RS21670 ENOG4107QX9 Thiol disulfide interChange protein GSY65_RS21680 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GSY65_RS21685 ENOG4105CRE cytochrome C GSY65_RS21760 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GSY65_RS21780 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GSY65_RS21790 ENOG4105DVY radical SAM domain protein GSY65_RS21805 ENOG4108R86 Transcriptional regulator GSY65_RS21840 ENOG4105VEQ Cold shock protein GSY65_RS21845 ENOG4105EV6 Pfam:DUF178 GSY65_RS21865 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GSY65_RS21880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GSY65_RS21900 ENOG4105K4H Nlp p60 protein GSY65_RS21910 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS21915 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GSY65_RS21920 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS21930 ENOG4107QIZ NADH dehydrogenase GSY65_RS21935 ENOG4108IEH NADH dehydrogenase subunit g GSY65_RS21940 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GSY65_RS21945 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS21950 ENOG41087XN oxidoreductase GSY65_RS21955 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS21960 ENOG4105D65 subunit l GSY65_RS21970 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS21980 ENOG4105C9U ATP-dependent DNA helicase RecQ GSY65_RS21985 ENOG4105ERH Fumarylacetoacetate hydrolase GSY65_RS21995 ENOG4105CAY ferredoxin--nadp reductase GSY65_RS22000 ENOG410667J hydrolase GSY65_RS22050 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GSY65_RS22105 ENOG4105E4C Lytic transglycosylase catalytic GSY65_RS22135 ENOG4105ECR NmrA family GSY65_RS22140 ENOG4105DQU oxidoreductase, subunit beta GSY65_RS22145 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GSY65_RS22165 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GSY65_RS22170 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS22175 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GSY65_RS22180 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GSY65_RS22185 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS22190 ENOG4107YX3 NADH dehydrogenase subunit j GSY65_RS22195 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS22205 ENOG4105C8S subunit m GSY65_RS22210 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GSY65_RS22215 ENOG4105D0M Protease HtpX homolog GSY65_RS22220 ENOG410901E Membrane GSY65_RS22230 ENOG4105Y3U Transglycosylase-associated protein GSY65_RS22235 ENOG4108VPT UPF0234 protein GSY65_RS22265 ENOG4105DZC cytosine deaminase GSY65_RS22280 ENOG4105WDJ 50S ribosomal protein L33 GSY65_RS22285 ENOG410900P UPF0336 protein GSY65_RS22305 ENOG4107R4N Cell wall formation (By similarity) GSY65_RS22310 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GSY65_RS22330 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GSY65_RS22335 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GSY65_RS22340 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GSY65_RS22345 ENOG4105QCJ Lipoprotein GSY65_RS22350 ENOG4108VZM 50s ribosomal protein L10 GSY65_RS22360 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GSY65_RS22365 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GSY65_RS22375 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GSY65_RS22380 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GSY65_RS22385 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GSY65_RS22390 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GSY65_RS22450 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GSY65_RS22455 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GSY65_RS22460 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GSY65_RS22465 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GSY65_RS22470 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GSY65_RS22475 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GSY65_RS22480 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GSY65_RS22485 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GSY65_RS22490 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GSY65_RS22495 ENOG41082SA 50s ribosomal protein l29 GSY65_RS22500 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GSY65_RS22505 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GSY65_RS22510 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GSY65_RS22515 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GSY65_RS22520 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GSY65_RS22530 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GSY65_RS22535 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GSY65_RS22540 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GSY65_RS22545 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GSY65_RS22550 ENOG410849U 50S ribosomal protein L30 GSY65_RS22555 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GSY65_RS22560 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GSY65_RS22565 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GSY65_RS22575 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GSY65_RS22580 ENOG41067V7 50S ribosomal protein L36 GSY65_RS22585 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GSY65_RS22590 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GSY65_RS22595 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GSY65_RS22600 ENOG4108ZT0 50S ribosomal protein l17 GSY65_RS22605 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GSY65_RS22615 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GSY65_RS22620 ENOG4108UJD 30S ribosomal protein S9 GSY65_RS22625 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GSY65_RS22635 ENOG4105CS9 pantothenic acid kinase GSY65_RS22655 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GSY65_RS22665 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GSY65_RS22675 ENOG4108097 ATP-binding protein GSY65_RS22695 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GSY65_RS22725 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GSY65_RS22735 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GSY65_RS22740 ENOG4105XN3 extracellular solute-binding protein family 1 GSY65_RS22755 ENOG4108KGH TRANSCRIPTIONal GSY65_RS22765 ENOG4105CHP RNA polymerase GSY65_RS22785 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GSY65_RS22795 ENOG4105EMU Dehydrogenase GSY65_RS22805 ENOG4105DND Transcriptional regulator GSY65_RS22825 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GSY65_RS22835 ENOG4105E6M Sulphatase-modifying factor protein GSY65_RS22855 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GSY65_RS22860 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS22865 ENOG4108MMM RNA Polymerase GSY65_RS22875 ENOG4107QVP Dehydrogenase GSY65_RS22880 ENOG4107QQG Dehydrogenase GSY65_RS22885 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GSY65_RS22895 ENOG4105D9P serine threonine protein kinase GSY65_RS22910 ENOG4105D9P serine threonine protein kinase GSY65_RS22920 ENOG4108I69 Glycosyl transferases group 1 GSY65_RS22930 ENOG4105C26 Dehydrogenase GSY65_RS22950 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GSY65_RS22990 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS23030 ENOG4105DR5 peptidase GSY65_RS23055 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GSY65_RS23060 ENOG4105RD5 GSY65_RS23070 ENOG4105DEG Vwa containing coxe family protein GSY65_RS23090 ENOG4105CMV Succinyl-CoA synthetase subunit beta GSY65_RS23120 ENOG4105DC1 bifunctional purine biosynthesis protein purh GSY65_RS23135 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GSY65_RS23150 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GSY65_RS23175 ENOG4106032 Glutathionylspermidine synthase GSY65_RS23180 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GSY65_RS23185 ENOG4105C31 Tryptophanyl-tRNA synthetase GSY65_RS23220 ENOG4107RN3 metallophosphoesterase GSY65_RS23225 ENOG4108J59 Extracellular solute-binding protein, family 5 GSY65_RS23230 ENOG4105U5Y Transcriptional regulator GSY65_RS23290 ENOG4108J01 L-aspartate oxidase GSY65_RS23310 ENOG4105E2D ec 3.2.1.52 GSY65_RS23340 ENOG4108MMM RNA Polymerase GSY65_RS23350 ENOG4108MMM RNA Polymerase GSY65_RS23370 ENOG4108NIW Leucine export protein LeuE GSY65_RS23385 ENOG4105K64 Glycosyl transferase, family 2 GSY65_RS23395 ENOG4105F0R Cytidylyltransferase GSY65_RS23400 ENOG4105D2T synthase GSY65_RS23410 ENOG4107RM1 amidohydrolase GSY65_RS23415 ENOG4105DIH basic membrane GSY65_RS23420 ENOG4105DIH basic membrane GSY65_RS23425 ENOG4108JQ9 ABC transporter GSY65_RS23430 ENOG4105UIB (ABC) transporter GSY65_RS23460 ENOG4105D94 Major Facilitator Superfamily GSY65_RS23465 ENOG4107RSM transcriptional regulator GSY65_RS23475 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GSY65_RS23500 ENOG41065SU Two-component system sensor kinase GSY65_RS23505 ENOG4108KXV response regulator GSY65_RS23510 ENOG4105NAF rna polymerase sigma factor GSY65_RS23535 ENOG4105C26 Dehydrogenase GSY65_RS23540 ENOG4105C26 Dehydrogenase GSY65_RS23560 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GSY65_RS23580 ENOG4105E98 transcriptional regulator DeoR family GSY65_RS23590 ENOG4108JIK carboxylase GSY65_RS23600 ENOG4107WR6 Maf-like protein GSY65_RS23615 ENOG4105D8K carboxyl transferase GSY65_RS23625 ENOG4108QER Adenylate cyclase GSY65_RS23630 ENOG4105E39 Enoyl-CoA hydratase GSY65_RS23635 ENOG4105KDM Diguanylate cyclase with gaf sensor GSY65_RS23640 ENOG4105C84 Histidine ammonia-lyase GSY65_RS23655 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GSY65_RS23665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS23675 ENOG4105DQ4 alcohol dehydrogenase GSY65_RS23680 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GSY65_RS23705 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GSY65_RS23725 ENOG4105NAF rna polymerase sigma factor GSY65_RS23730 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GSY65_RS23735 ENOG4105C7B Threonine dehydratase GSY65_RS23755 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GSY65_RS23765 ENOG4105T1M mycothiol conjugate amidase mca GSY65_RS23795 ENOG4105C7Z Conserved Protein GSY65_RS23825 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GSY65_RS24055 ENOG4107QKZ Ompa motb domain protein GSY65_RS24075 ENOG4105NAE bifunctional deaminase-reductase domain protein GSY65_RS24090 ENOG4108IAB Phoh family GSY65_RS24095 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GSY65_RS24105 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GSY65_RS24110 ENOG4105D3R alkyl hydroperoxide reductase GSY65_RS24125 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GSY65_RS24135 ENOG4105BZ4 penicillin-binding protein GSY65_RS24150 ENOG4105C9Q fumarate hydratase class II GSY65_RS24155 ENOG4107GFK fumarate GSY65_RS24165 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GSY65_RS24180 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GSY65_RS24190 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GSY65_RS24195 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GSY65_RS24210 ENOG4105C3G gtp-binding protein GSY65_RS24215 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GSY65_RS24220 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GSY65_RS24230 ENOG4105JAB phenazine biosynthesis protein, phzf family GSY65_RS24240 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS24280 ENOG4108JNI Alpha beta hydrolase GSY65_RS24305 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase GSY65_RS24310 ENOG4105DDQ anthranilate synthase GSY65_RS24330 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS24415 ENOG4105E33 succinate dehydrogenase GSY65_RS24420 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GSY65_RS24440 ENOG4105CI3 gtp-binding protein typa GSY65_RS24445 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GSY65_RS24450 ENOG4108J59 Extracellular solute-binding protein, family 5 GSY65_RS24465 ENOG4108JQ7 (ABC) transporter GSY65_RS24475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GSY65_RS24480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GSY65_RS24485 ENOG4105C3U ABC transporter GSY65_RS24490 ENOG4108JQ7 (ABC) transporter GSY65_RS24505 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GSY65_RS24535 ENOG4108Z4U Ferredoxin GSY65_RS24555 ENOG4107R4C succinyl-diaminopimelate desuccinylase GSY65_RS24560 ENOG4108URH decarboxylase GSY65_RS24565 ENOG4105EEI dihydropteroate synthase GSY65_RS24575 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GSY65_RS24580 ENOG4105CGU Enoyl-CoA hydratase GSY65_RS24595 ENOG4105DU6 RNA polymerase GSY65_RS24605 ENOG4105C0H protease GSY65_RS24610 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GSY65_RS24645 ENOG4105D7N magnesium and cobalt transport protein CorA GSY65_RS24665 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GSY65_RS24780 ENOG4105C4R Atp-dependent dna helicase GSY65_RS24785 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GSY65_RS24810 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GSY65_RS24875 ENOG41063PX domain protein GSY65_RS24885 ENOG4105DJZ UPF0182 protein GSY65_RS24915 ENOG4107TK4 histidinol-phosphate phosphatase GSY65_RS24925 ENOG4105KPY Small multidrug resistance protein GSY65_RS24935 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GSY65_RS24945 ENOG4108RAV Conserved protein GSY65_RS24955 ENOG4105EMN RNA polymerase sigma factor GSY65_RS24960 ENOG4105WMN AntiSigma factor GSY65_RS24975 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GSY65_RS24990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GSY65_RS25005 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GSY65_RS25010 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GSY65_RS25020 ENOG4105DU0 nucleoside hydrolase GSY65_RS25035 ENOG4105FDP GntR family transcriptional regulator GSY65_RS25055 ENOG4105D17 glycoside hydrolase, family 3 domain protein GSY65_RS25060 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GSY65_RS25080 ENOG4105CBD Diacylglycerol kinase GSY65_RS25110 ENOG4105K6H D-cysteine desulfhydrase GSY65_RS25120 ENOG4105ESN nucleotide-binding protein GSY65_RS25155 ENOG4105DRS transport system, permease GSY65_RS25170 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS25285 ENOG4105VTR Integrase GSY65_RS25290 ENOG4108VEQ Superoxide dismutase GSY65_RS25310 ENOG4105CDA abc transporter atp-binding protein GSY65_RS25325 ENOG4105C6K Malic enzyme GSY65_RS25330 ENOG4105CB2 alcohol dehydrogenase GSY65_RS25365 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GSY65_RS25370 ENOG4105EB3 Histidine kinase GSY65_RS25375 ENOG4108PYU two-component system response regulator GSY65_RS25395 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GSY65_RS25445 ENOG41060BG Tetr family transcriptional regulator GSY65_RS25470 ENOG4108FKE two-component system sensor kinase GSY65_RS25490 ENOG4105DQE DNA ligase GSY65_RS25495 ENOG4105FDF Could be involved in DNA repair (By similarity) GSY65_RS25525 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GSY65_RS25530 ENOG4105EHG Permease protein GSY65_RS25655 ENOG4105ETX regulatoR GSY65_RS25660 ENOG4105C75 arginyL-tRNA synthetase GSY65_RS25665 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GSY65_RS25670 ENOG4105D6E homoserine dehydrogenase GSY65_RS25675 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GSY65_RS25680 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GSY65_RS25690 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GSY65_RS25700 ENOG4105VFB Binds the 23S rRNA (By similarity) GSY65_RS25705 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GSY65_RS25710 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GSY65_RS25720 ENOG4107ZF2 Phosphatase GSY65_RS25725 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GSY65_RS25740 ENOG4105Z3P ATP synthase GSY65_RS25750 ENOG4105ZA1 atp synthase GSY65_RS25755 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GSY65_RS25760 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GSY65_RS25765 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GSY65_RS25770 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GSY65_RS25775 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GSY65_RS25780 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GSY65_RS25795 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS25800 ENOG4105BZU Histidine kinase GSY65_RS25805 ENOG4105IIP Membrane GSY65_RS25830 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GSY65_RS25845 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GSY65_RS25895 ENOG4105CHU acetyl-coa acetyltransferase GSY65_RS25910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS25915 ENOG41062D9 Histidine kinase GSY65_RS25960 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GSY65_RS26010 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GSY65_RS26015 ENOG4105C6K Malic enzyme GSY65_RS26020 ENOG4105CTQ phosphohexokinase GSY65_RS26035 ENOG4108MRH transcriptional regulatory protein GSY65_RS26040 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GSY65_RS26050 ENOG4107QJT sodium dicarboxylate symporter GSY65_RS26075 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GSY65_RS26080 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GSY65_RS26090 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GSY65_RS26095 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY65_RS26100 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GSY65_RS26120 ENOG4105BZ1 (ABC) transporter GSY65_RS26125 ENOG4105BZ1 (ABC) transporter GSY65_RS26130 ENOG4105BZ1 (ABC) transporter GSY65_RS26135 ENOG4105BZ1 (ABC) transporter GSY65_RS26150 ENOG4105S7A ErfK ybiS ycfS ynhG family protein GSY65_RS26155 ENOG4105UPE Enoyl-CoA hydratase GSY65_RS26180 ENOG4105EJQ L-serine dehydratase GSY65_RS26185 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GSY65_RS26190 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GSY65_RS26195 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GSY65_RS26220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GSY65_RS26240 ENOG4108JQ7 (ABC) transporter GSY65_RS26245 ENOG4105EN6 Membrane GSY65_RS26275 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GSY65_RS26280 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GSY65_RS26290 ENOG4108URH decarboxylase GSY65_RS26295 ENOG4105EMU Dehydrogenase GSY65_RS26305 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GSY65_RS26310 ENOG4105BZU Histidine kinase GSY65_RS26315 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GSY65_RS26320 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GSY65_RS26330 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GSY65_RS26335 ENOG4105EYF MMPL domain protein GSY65_RS26340 ENOG4105D9U N-acetyltransferase GSY65_RS26350 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS26360 ENOG4105CPC Aldo Keto reductase GSY65_RS26380 ENOG4108ZP8 Acetolactate synthase small subunit GSY65_RS26385 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GSY65_RS26395 ENOG4105C57 major facilitator superfamily GSY65_RS26420 ENOG4105DEF Extracellular solute-binding protein, family 5 GSY65_RS26425 ENOG4107YHD transcriptional regulator GSY65_RS26435 ENOG4105C26 Dehydrogenase GSY65_RS26455 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GSY65_RS26460 ENOG4105CM2 brancheD-chain amino acid aminotransferase GSY65_RS26470 ENOG4105CQM Urea amidohydrolase subunit alpha GSY65_RS26475 ENOG4105DWY Agmatine deiminase GSY65_RS26495 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GSY65_RS26505 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GSY65_RS26520 ENOG4106AM8 polysaccharide lyase family 8 GSY65_RS26525 ENOG4105D8K carboxyl transferase GSY65_RS26545 ENOG4105GWZ Roadblock lc7 family protein GSY65_RS26565 ENOG4105GWZ Roadblock lc7 family protein GSY65_RS26580 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GSY65_RS26585 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GSY65_RS26630 ENOG41069M3 Transcriptional regulator GSY65_RS26635 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GSY65_RS26640 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GSY65_RS26650 ENOG4105K70 DNA-binding protein GSY65_RS26660 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) GSY65_RS26670 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GSY65_RS26675 ENOG4105CPF Cell wall formation (By similarity) GSY65_RS26695 ENOG4105DWF phosphomethylpyrimidine kinase GSY65_RS26700 ENOG4105VB9 50S ribosomal protein l28 GSY65_RS26705 ENOG4105DP4 dak2 domain fusion protein ylov GSY65_RS26715 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GSY65_RS26725 ENOG4106H78 methyltransferase GSY65_RS26730 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GSY65_RS26745 ENOG41084BZ 50S ribosomal protein L32 GSY65_RS26750 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GSY65_RS26755 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GSY65_RS26760 ENOG4105KVH Transcriptional regulator GSY65_RS26780 ENOG4105K4I Scp-like extracellular GSY65_RS26785 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GSY65_RS26795 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GSY65_RS26835 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GSY65_RS26850 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) GSY65_RS26860 ENOG4105K5M 30s ribosomal protein S16 GSY65_RS26865 ENOG41082KU UPF0109 protein GSY65_RS26870 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GSY65_RS26875 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GSY65_RS26880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GSY65_RS26895 ENOG4107QYR Signal peptidase i GSY65_RS26900 ENOG4107QYR Signal peptidase i GSY65_RS26905 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GSY65_RS26915 ENOG41080R2 UPF0102 protein GSY65_RS26920 ENOG4105C0P Mg chelatase subunit ChlI GSY65_RS26930 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS26945 ENOG4105CE9 30S ribosomal protein S2 GSY65_RS26950 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GSY65_RS26955 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GSY65_RS26960 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GSY65_RS26965 ENOG4105KNE Phosphatidate cytidylyltransferase GSY65_RS26970 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GSY65_RS26980 ENOG4108I5D sulfate abc transporter GSY65_RS26985 ENOG4108UCS ABC, transporter GSY65_RS27015 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GSY65_RS27025 ENOG4105C26 Dehydrogenase GSY65_RS27050 ENOG4108YYC ycei family GSY65_RS27065 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GSY65_RS27090 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GSY65_RS27095 ENOG4105F38 ABC transporter, permease GSY65_RS27100 ENOG4105D38 putrescine abc transporter GSY65_RS27105 ENOG4105CJP fad dependent oxidoreductase GSY65_RS27130 ENOG4105G9B Transcriptional regulator GSY65_RS27135 ENOG4105C26 Dehydrogenase GSY65_RS27140 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GSY65_RS27155 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GSY65_RS27185 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS27205 ENOG4108REF Sporulation integral membrane protein ytvi GSY65_RS27215 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS27230 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GSY65_RS27235 ENOG4105DZP Membrane-associated zinc metalloprotease GSY65_RS27240 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GSY65_RS27255 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GSY65_RS27260 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase GSY65_RS27275 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GSY65_RS27290 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GSY65_RS27300 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GSY65_RS27305 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GSY65_RS27360 ENOG4105EC2 ftsk spoIIIe GSY65_RS27370 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GSY65_RS27375 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GSY65_RS27380 ENOG4105C1V Peptidase, M16 GSY65_RS27385 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GSY65_RS27410 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GSY65_RS27415 ENOG4105CN5 Metallo-Beta-Lactamase GSY65_RS27450 ENOG4105BZU Histidine kinase GSY65_RS27455 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GSY65_RS27460 ENOG4107QZI cell division protein FtsK GSY65_RS27470 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GSY65_RS27480 ENOG4105CEV competence damage-inducible protein GSY65_RS27485 ENOG4105WBV Transcriptional regulator GSY65_RS27490 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GSY65_RS27495 ENOG4105CHR reductase GSY65_RS27500 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GSY65_RS27505 ENOG4107QRT dEAD DEAH box helicase GSY65_RS27535 ENOG4105DSF transport protein GSY65_RS27540 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GSY65_RS27555 ENOG4107SCK Monooxygenase GSY65_RS27560 ENOG4105DRP amino acid AbC transporter GSY65_RS27565 ENOG4108Q1T ABC transporter GSY65_RS27570 ENOG4107UBR Extracellular solute-binding protein family 3 GSY65_RS27575 ENOG4105CDA abc transporter atp-binding protein GSY65_RS27580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS27585 ENOG4105EB3 Histidine kinase GSY65_RS27610 ENOG4107HP6 Transcriptional regulator GSY65_RS27635 ENOG41088PD hydrolase GSY65_RS27640 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase GSY65_RS27660 ENOG4105DP7 Protocatechuate 4,5-dioxygenase GSY65_RS27665 ENOG4105IKQ hydratase GSY65_RS27680 ENOG4105CSH Transporter GSY65_RS27685 ENOG4106A3M Cytochrome p-450 GSY65_RS27695 ENOG4105C84 Histidine ammonia-lyase GSY65_RS27710 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GSY65_RS27730 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GSY65_RS27740 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GSY65_RS27745 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GSY65_RS27755 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GSY65_RS27785 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GSY65_RS27790 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GSY65_RS27795 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GSY65_RS27810 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GSY65_RS27830 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GSY65_RS27845 ENOG4105C9U ATP-dependent DNA helicase RecQ GSY65_RS27870 ENOG4105E2Y ABC, transporter GSY65_RS27875 ENOG4105JXH GntR family transcriptional regulator GSY65_RS27880 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS27885 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GSY65_RS27895 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GSY65_RS27905 ENOG4107QN1 sodium solute GSY65_RS27910 ENOG4108V9W transcriptional regulatory protein GSY65_RS27915 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GSY65_RS27925 ENOG4105CKI cobalamin synthesis protein GSY65_RS27930 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GSY65_RS27950 ENOG4105DRR Transcriptional regulator, GntR family GSY65_RS27955 ENOG410849S phosphocarrier protein (HPr) GSY65_RS27965 ENOG4105CD5 CoA-binding domain protein GSY65_RS27980 ENOG4107W53 thymidine kinase GSY65_RS28010 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GSY65_RS28020 ENOG4105F44 Two component transcriptional regulator, winged helix family GSY65_RS28025 ENOG4106F60 Histidine kinase GSY65_RS28050 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GSY65_RS28075 ENOG4107VEG TrkA-N domain protein GSY65_RS28080 ENOG4105C0X amino acid GSY65_RS28085 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GSY65_RS28120 ENOG4107ZT5 Thiol disulfide interchange protein GSY65_RS28175 ENOG4105VEQ Cold shock protein GSY65_RS28180 ENOG4105C1J atp-dependent rna helicase GSY65_RS28280 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GSY65_RS28285 ENOG4105D7T ABC transporter GSY65_RS28290 ENOG4107UWC ABC, transporter GSY65_RS28305 ENOG4105CPU Monooxygenase GSY65_RS28330 ENOG4107NHD transcriptional regulator GSY65_RS28335 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GSY65_RS28355 ENOG4105DEN Luciferase family GSY65_RS28370 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS28420 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GSY65_RS28450 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GSY65_RS28460 ENOG4107S1Q Phosphatase GSY65_RS28465 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GSY65_RS28480 ENOG4105CEU Arginine dihydrolase GSY65_RS28485 ENOG4105DBV ornithine carbamoyltransferase GSY65_RS28590 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GSY65_RS28595 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GSY65_RS28600 ENOG4105CZA synthase GSY65_RS28630 ENOG4107QVI Methyltransferase, type 11 GSY65_RS28635 ENOG4105C8Y Acetylornithine aminotransferase GSY65_RS28650 ENOG4105CJ1 ABC, transporter GSY65_RS28665 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS28680 ENOG4105DZH s-adenosylmethionine synthetase (EC 2.5.1.6) GSY65_RS28690 ENOG4105CHR reductase GSY65_RS28695 ENOG4105DCG PHP domain protein GSY65_RS28700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GSY65_RS28715 ENOG4107QM5 aconitate hydratase GSY65_RS28745 ENOG4105DRS transport system, permease GSY65_RS28750 ENOG4105E2R ROK family GSY65_RS28755 ENOG4105DFW ABC transporter GSY65_RS28760 ENOG4105C2J ABC transporter GSY65_RS28765 ENOG4108HWW ABC transporter GSY65_RS28770 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GSY65_RS28775 ENOG4105CUB amino acid GSY65_RS28785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GSY65_RS28790 ENOG4105CHU acetyl-coa acetyltransferase GSY65_RS28795 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS28810 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GSY65_RS28815 ENOG4105DRS transport system, permease GSY65_RS28820 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GSY65_RS28835 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GSY65_RS28850 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GSY65_RS28865 ENOG4107JTW chlorite dismutase GSY65_RS28880 ENOG4105E18 UPF0276 protein GSY65_RS28925 ENOG4107B2H carbonic anhydrase GSY65_RS28950 ENOG4105DFU Cell wall formation (By similarity) GSY65_RS28955 ENOG4105E0X reductase GSY65_RS28970 ENOG4105EFZ amidohydrolase GSY65_RS28975 ENOG4105CHJ isochorismatase hydrolase GSY65_RS28980 ENOG4108VGI doxx family GSY65_RS28985 ENOG4105XPP Protein of unknown function (DUF1275) GSY65_RS29030 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS29055 ENOG4108U3T pfkb domain protein GSY65_RS29070 ENOG4105GWZ Roadblock lc7 family protein GSY65_RS29080 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GSY65_RS29095 ENOG410620I Diguanylate cyclase GSY65_RS29130 ENOG4106A3M Cytochrome p-450 GSY65_RS29170 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY65_RS29185 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein GSY65_RS29190 ENOG4105C0H protease GSY65_RS29195 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GSY65_RS29225 ENOG4105ZSU inhibitor GSY65_RS29310 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GSY65_RS29315 ENOG4108IY8 ABC, transporter GSY65_RS29340 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) GSY65_RS29345 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GSY65_RS29370 ENOG4107RR1 TRANSCRIPTIONal GSY65_RS29375 ENOG4105CSU acyl-Coa dehydrogenase GSY65_RS29410 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS29430 ENOG4105EBR Carboxylesterase GSY65_RS29455 ENOG4107X2D transcriptional regulator, merr family GSY65_RS29470 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GSY65_RS29490 ENOG4105M4P Tetr family transcriptional regulator GSY65_RS29495 ENOG4108J5H Homocysteine s-methyltransferase GSY65_RS29500 ENOG4105D5Q Arginine ornithine antiporter GSY65_RS29525 ENOG4107TDE lipolytic protein G-D-S-L family GSY65_RS29550 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GSY65_RS29555 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GSY65_RS29565 ENOG4105E2R ROK family GSY65_RS29570 ENOG4105QE3 oxidoreductase GSY65_RS29585 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GSY65_RS29590 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GSY65_RS29630 ENOG4105DRR Transcriptional regulator, GntR family GSY65_RS29660 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GSY65_RS29665 ENOG4105C7N Xanthine uracil vitamin C permease GSY65_RS29690 ENOG4105DDC Oxidoreductase domain protein GSY65_RS29700 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GSY65_RS29705 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GSY65_RS29720 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS29725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GSY65_RS29735 ENOG4105FDP GntR family transcriptional regulator GSY65_RS29740 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GSY65_RS29750 ENOG4105EDK PfkB domain protein GSY65_RS29760 ENOG4105CNN ABC, transporter GSY65_RS29765 ENOG4105C2J ABC transporter GSY65_RS29775 ENOG4105C4X radical SAM domain protein GSY65_RS29805 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GSY65_RS29815 ENOG41081F0 Precorrin-8x methylmutase GSY65_RS29825 ENOG4107RSM transcriptional regulator GSY65_RS29830 ENOG4105CHU acetyl-coa acetyltransferase GSY65_RS29840 ENOG4107QNJ CoA-transferase subunit B GSY65_RS29870 ENOG4105C85 amino acid GSY65_RS29895 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GSY65_RS29930 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GSY65_RS29935 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GSY65_RS29940 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GSY65_RS29950 ENOG4105EB3 Histidine kinase GSY65_RS29955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY65_RS29975 ENOG4105D7N magnesium and cobalt transport protein CorA GSY65_RS30000 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GSY65_RS30005 ENOG4105CEY Amp-dependent synthetase and ligase GSY65_RS30015 ENOG41060W2 glyoxylate carboligase GSY65_RS30020 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GSY65_RS30025 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GSY65_RS30045 ENOG4105DPX Hydrogenase, large subunit GSY65_RS30075 ENOG4105C45 hydrogenase expression formation protein (HypE) GSY65_RS30080 ENOG4105CQS hydrogenase expression formation protein HypD GSY65_RS30095 ENOG4107RSS Hydrogenase accessory protein HypB GSY65_RS30105 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GSY65_RS30125 ENOG4105VT2 5-hydroxyisourate hydrolase GSY65_RS30135 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GSY65_RS30155 ENOG4105CVJ phosphoglycerate mutase GSY65_RS30160 ENOG4105CHM Aminotransferase GSY65_RS30205 ENOG4105CAQ asparagine synthetase GSY65_RS30210 ENOG4105C0I Conserved Protein GSY65_RS30230 ENOG4105DQ5 transport system permease protein GSY65_RS30235 ENOG4105E0A ABC, transporter GSY65_RS30260 ENOG4105BZ1 (ABC) transporter GSY65_RS30265 ENOG4105BZ1 (ABC) transporter GSY65_RS30285 ENOG4108PTX LysR family Transcriptional regulator GSY65_RS30305 ENOG4107R9S Malate synthase GSY65_RS30325 ENOG4107HP6 Transcriptional regulator GSY65_RS30355 ENOG4105CPC Aldo Keto reductase GSY65_RS30360 ENOG4105WH1 Two component transcriptional regulator luxr family GSY65_RS30375 ENOG4106448 streptomycin biosynthesis protein strI GSY65_RS30380 ENOG4105FDP GntR family transcriptional regulator GSY65_RS30385 ENOG4105DKQ ROK family GSY65_RS30395 ENOG4105C0D helicase GSY65_RS30415 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY65_RS30430 ENOG4105E4C Lytic transglycosylase catalytic GSY65_RS30540 ENOG4108R5S membrane GSY65_RS30565 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GSY65_RS30625 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GSY65_RS30685 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GSY65_RS30700 ENOG4105F44 Two component transcriptional regulator, winged helix family GSY65_RS30705 ENOG4105BZU Histidine kinase GSY65_RS30760 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GSY65_RS30795 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GSY65_RS30830 ENOG4105EUJ GTP cyclohydrolase i GSY65_RS30835 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GSY65_RS30895 ENOG4105BZP glycoside hydrolase 15-related GSY65_RS30945 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GSY65_RS30950 ENOG4105E8R UPF0173 metal-dependent hydrolase GSY65_RS30985 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GSY65_RS31010 ENOG4108JPW Aminotransferase GSY65_RS31025 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GSY65_RS31035 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GSY65_RS31055 ENOG4105ECY inositol monophosphatase GSY65_RS31065 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase GSY65_RS31070 ENOG4105F0H myo-inositol catabolism protein GSY65_RS31100 ENOG4108UVJ appr-1-p processing domain protein GSY65_RS31110 ENOG41066UM arsR family transcriptional regulator GSY65_RS31125 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GSY65_RS31150 ENOG4105BZW Glycerate kinase GSY65_RS31165 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GSY65_RS31170 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS31185 ENOG4105RFZ Methylmalonyl-coA mutase GSY65_RS31190 ENOG4105EE1 crotonyl-CoA reductase GSY65_RS31200 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GSY65_RS31215 ENOG4106JDR secreted GSY65_RS31245 ENOG4108ME1 Peptidase M55 D-aminopeptidase GSY65_RS31250 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GSY65_RS31255 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GSY65_RS31260 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GSY65_RS31310 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GSY65_RS31335 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GSY65_RS31345 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GSY65_RS31355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GSY65_RS31360 ENOG4105YVM Phosphoesterase, PA-phosphatase related GSY65_RS31365 ENOG4105C5H ABC transporter GSY65_RS31385 ENOG4108Z0Z intracellular protease Pfpi family GSY65_RS31435 ENOG4105E8R UPF0173 metal-dependent hydrolase GSY65_RS31460 ENOG4105CFG Acts as a chaperone (By similarity) GSY65_RS31480 ENOG410842T Pterin carbinolamine dehydratase GSY65_RS31495 ENOG4105CX8 fg-gap repeat protein GSY65_RS31505 ENOG4105CYP glycoside hydrolase, family GSY65_RS31510 ENOG41065HY 1,4-beta-cellobiosidase GSY65_RS31525 ENOG4105CV8 reductase GSY65_RS31535 ENOG4107653 Transcriptional regulator GSY65_RS31540 ENOG4105DHU Bile acid GSY65_RS31550 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GSY65_RS31565 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GSY65_RS31570 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GSY65_RS31580 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GSY65_RS31590 ENOG4105DKQ ROK family GSY65_RS31595 ENOG4105C2J ABC transporter GSY65_RS31600 ENOG4105CNN ABC, transporter GSY65_RS31605 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GSY65_RS31665 ENOG4105FCD Major Facilitator GSY65_RS31685 ENOG4105CMV Succinyl-CoA synthetase subunit beta GSY65_RS31695 ENOG4105C26 Dehydrogenase GSY65_RS31705 ENOG4107V9E glucose-1-phosphate thymidylyltransferase GSY65_RS31730 ENOG4105D3P Mannan endo-1,4-beta-mannosidase GSY65_RS31750 ENOG4108HMN Caspase domain GSY65_RS31775 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS31780 ENOG4105CK5 oxidoreductase GSY65_RS31785 ENOG4105CHR reductase GSY65_RS31795 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS31825 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GSY65_RS31845 ENOG4107QJN gtp cyclohydrolase ii GSY65_RS31885 ENOG410905P Pyridoxamine 5-phosphate GSY65_RS31895 ENOG4105CSH Transporter GSY65_RS31905 ENOG4107S9B Shikimate dehydrogenase GSY65_RS31915 ENOG4108J5G 6-phosphogluconate dehydrogenase GSY65_RS31920 ENOG4107QP8 phosphohexose isomerase GSY65_RS31935 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GSY65_RS31940 ENOG4105CV1 Transketolase (EC 2.2.1.1) GSY65_RS31995 ENOG41088CQ domain protein GSY65_RS32025 ENOG4108MGF sugar kinase GSY65_RS32030 ENOG4105E98 transcriptional regulator DeoR family GSY65_RS32035 ENOG4105F8D glycoside hydrolase family 4 GSY65_RS32160 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GSY65_RS32175 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GSY65_RS32180 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GSY65_RS32185 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GSY65_RS32200 ENOG4108R5T secreted protein GSY65_RS32215 ENOG4105DQE DNA ligase GSY65_RS32250 ENOG4105ETE Transcriptional regulator (LacI family GSY65_RS32265 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GSY65_RS32275 ENOG4106V2I dimethylaminohydrolase GSY65_RS32280 ENOG4105C5H ABC transporter GSY65_RS32285 ENOG4105KF0 sporulation and cell division protein, SsgA GSY65_RS32300 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GSY65_RS32305 ENOG4105EG6 Saccharopine dehydrogenase GSY65_RS32315 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GSY65_RS32320 ENOG4105CHU acetyl-coa acetyltransferase GSY65_RS32325 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GSY65_RS32340 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GSY65_RS32355 ENOG4105C94 Transporter GSY65_RS32370 ENOG4105C5H ABC transporter GSY65_RS32375 ENOG4105BZM domain protein GSY65_RS32390 ENOG4105E39 Enoyl-CoA hydratase GSY65_RS32405 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GSY65_RS32430 ENOG4108MDK Dehydrogenase GSY65_RS32450 ENOG4105EY8 ABC transporter GSY65_RS32455 ENOG4105FBD synthase GSY65_RS32465 ENOG4107S11 squalene-associated FAD-dependent desaturase GSY65_RS32475 ENOG4105EWU Squalene--hopene cyclase GSY65_RS32490 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GSY65_RS32530 ENOG41090WU lipolytic protein G-D-S-L family GSY65_RS32540 ENOG4105D82 Glutamate dehydrogenase GSY65_RS32550 ENOG4107RBB ABC transporter, permease GSY65_RS32555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS32565 ENOG4105CHR reductase GSY65_RS32570 ENOG4105CI0 Citrate lyase GSY65_RS32580 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GSY65_RS32585 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GSY65_RS32600 ENOG4105E7W lamb ycsf family protein GSY65_RS32605 ENOG4108Q50 Histidine kinase GSY65_RS32610 ENOG4105FBW Monooxygenase GSY65_RS32645 ENOG4108M9J MaoC like domain protein GSY65_RS32650 ENOG4105C10 Electron transfer flavoprotein GSY65_RS32660 ENOG4105C1G acyl-Coa dehydrogenase GSY65_RS32665 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GSY65_RS32680 ENOG4105EMU Dehydrogenase GSY65_RS32715 ENOG4105CPQ Dehydrogenase GSY65_RS32720 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GSY65_RS32725 ENOG4106NZI LysR family Transcriptional regulator GSY65_RS32735 ENOG4105RHY Pfam:UPF0157 GSY65_RS32765 ENOG4105C9B Cysteine desulfurase GSY65_RS32795 ENOG4105CTU Proline racemase GSY65_RS32800 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GSY65_RS32805 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GSY65_RS32815 ENOG4105MWK D-amino acid dehydrogenase, small subunit GSY65_RS32815 ENOG4105MWK D-amino acid dehydrogenase, small subunit GSY65_RS32820 ENOG4105BZP glycoside hydrolase 15-related GSY65_RS32835 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GSY65_RS32840 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GSY65_RS32845 ENOG4105E8V Alpha Beta Hydrolase Fold protein GSY65_RS32855 ENOG4105U0R haloacid dehalogenase-like hydrolase GSY65_RS32870 ENOG4105BZ1 (ABC) transporter GSY65_RS32890 ENOG4107RQ0 Maleylacetate reductase GSY65_RS32895 ENOG4108YYC ycei family GSY65_RS32910 ENOG4105C4X radical SAM domain protein GSY65_RS32955 ENOG4105K56 Transcriptional regulator GSY65_RS32965 ENOG4105E9K Isocitrate dehydrogenase GSY65_RS32970 ENOG4105D64 Mechanosensitive ion channel GSY65_RS32980 ENOG4105BZ1 (ABC) transporter GSY65_RS33015 ENOG4105C1J atp-dependent rna helicase GSY65_RS33035 ENOG4107RBB ABC transporter, permease GSY65_RS33040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GSY65_RS33055 ENOG4105EB3 Histidine kinase GSY65_RS33060 ENOG4105E3W Two component transcriptional regulator (Winged helix family GSY65_RS33085 ENOG4105EC2 ftsk spoIIIe GSY65_RS33155 ENOG4105JZI cytochrome P450