locus-tag	class	description
GSY65_RS00245	COG4249	Peptidase C14 caspase catalytic subunit p20
GSY65_RS00245	COG2319	Wd-40 repeat
GSY65_RS00265	COG3328	transposase activity
GSY65_RS00330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSY65_RS00335	COG1518	maintenance of DNA repeat elements
GSY65_RS00375	COG1846	Transcriptional regulator
GSY65_RS00430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS00440	COG0431	NADPH-dependent FMN reductase
GSY65_RS00455	COG0583	DNA-binding transcription factor activity
GSY65_RS00460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS00465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS00495	COG0765	amino acid transport
GSY65_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS00525	COG0477	Major facilitator Superfamily
GSY65_RS00555	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS00580	COG2175	clavaminate synthase activity
GSY65_RS00590	COG3629	intracellular signal transduction
GSY65_RS00590	COG3903	Transcriptional regulator
GSY65_RS00610	COG0022	dehydrogenase e1 component
GSY65_RS00620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GSY65_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSY65_RS00630	COG1408	metallophosphoesterase
GSY65_RS00635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GSY65_RS00710	COG1131	(ABC) transporter
GSY65_RS00720	COG4585	Histidine kinase
GSY65_RS00725	COG2197	response regulator
GSY65_RS00755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GSY65_RS00785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSY65_RS00810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GSY65_RS00830	COG0456	acetyltransferase
GSY65_RS00835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GSY65_RS00865	COG1191	sigma factor activity
GSY65_RS00875	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY65_RS00880	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY65_RS00885	COG2172	sigma factor antagonist activity
GSY65_RS00930	COG0640	Transcriptional regulator
GSY65_RS00935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GSY65_RS00940	COG2072	flavoprotein involved in K transport
GSY65_RS00960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSY65_RS00970	COG0667	Aldo Keto reductase
GSY65_RS00975	COG0477	Major facilitator Superfamily
GSY65_RS00990	COG0494	nUDIX hydrolase
GSY65_RS01020	COG0328	RNA-DNA hybrid ribonuclease activity
GSY65_RS01040	COG0861	Integral membrane protein TerC family
GSY65_RS01050	COG0740	serine-type endopeptidase activity
GSY65_RS01055	COG0740	serine-type endopeptidase activity
GSY65_RS01060	COG1396	sequence-specific DNA binding
GSY65_RS01080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GSY65_RS01095	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GSY65_RS01100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSY65_RS01105	COG1120	ATPase activity
GSY65_RS01110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY65_RS01115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY65_RS01130	COG4607	ABC-type enterochelin transport system periplasmic component
GSY65_RS01135	COG1132	(ABC) transporter
GSY65_RS01140	COG1132	(ABC) transporter
GSY65_RS01150	COG2814	Major facilitator Superfamily
GSY65_RS01160	COG0698	ribose 5-phosphate isomerase
GSY65_RS01190	COG0667	Aldo Keto reductase
GSY65_RS01195	COG0583	DNA-binding transcription factor activity
GSY65_RS01210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSY65_RS01215	COG0346	lactoylglutathione lyase activity
GSY65_RS01245	COG2409	Drug exporters of the RND superfamily
GSY65_RS01250	COG1846	Transcriptional regulator
GSY65_RS01255	COG0702	epimerase
GSY65_RS01270	COG1595	DNA-templated transcription, initiation
GSY65_RS01290	COG0456	acetyltransferase
GSY65_RS01290	COG0454	-acetyltransferase
GSY65_RS01400	COG1024	Enoyl-CoA hydratase
GSY65_RS01410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GSY65_RS01415	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS01420	COG2366	antibiotic biosynthetic process
GSY65_RS01430	COG2070	2-Nitropropane dioxygenase
GSY65_RS01445	COG1595	DNA-templated transcription, initiation
GSY65_RS01475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GSY65_RS01480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GSY65_RS01490	COG0493	'glutamate synthase
GSY65_RS01505	COG4191	Histidine kinase
GSY65_RS01520	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS01545	COG0726	polysaccharide deacetylase
GSY65_RS01555	COG0640	Transcriptional regulator
GSY65_RS01570	COG0310	cobalt ion transport
GSY65_RS01575	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GSY65_RS01585	COG1122	ATPase activity
GSY65_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS01610	COG4948	Mandelate Racemase Muconate Lactonizing
GSY65_RS01615	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSY65_RS01635	COG3940	Belongs to the glycosyl hydrolase 43 family
GSY65_RS01675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSY65_RS01695	COG4555	ABC transporter
GSY65_RS01730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GSY65_RS01740	COG0138	bifunctional purine biosynthesis protein purh
GSY65_RS01785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSY65_RS01795	COG0667	Aldo Keto reductase
GSY65_RS01820	COG3507	Belongs to the glycosyl hydrolase 43 family
GSY65_RS01835	COG0517	IMP dehydrogenase activity
GSY65_RS01835	COG0516	GMP reductase activity
GSY65_RS01880	COG2208	phosphoserine phosphatase activity
GSY65_RS01880	COG2770	Histidine kinase
GSY65_RS01915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GSY65_RS01930	COG0574	Belongs to the PEP-utilizing enzyme family
GSY65_RS01930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSY65_RS01940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GSY65_RS01965	COG0517	IMP dehydrogenase activity
GSY65_RS01990	COG0589	response to stress
GSY65_RS02000	COG0659	secondary active sulfate transmembrane transporter activity
GSY65_RS02060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSY65_RS02070	COG2197	response regulator
GSY65_RS02075	COG4585	Histidine kinase
GSY65_RS02130	COG0477	Major facilitator Superfamily
GSY65_RS02150	COG0156	8-amino-7-oxononanoate synthase activity
GSY65_RS02155	COG4335	DNA alkylation repair
GSY65_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS02165	COG3321	synthase
GSY65_RS02165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY65_RS02165	COG4221	oxidoreductase activity
GSY65_RS02180	COG0644	oxidoreductase
GSY65_RS02195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GSY65_RS02210	COG2376	Dihydroxyacetone kinase
GSY65_RS02215	COG1461	Dihydroxyacetone kinase
GSY65_RS02245	COG1902	pentaerythritol trinitrate reductase activity
GSY65_RS02245	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSY65_RS02250	COG2890	protein-(glutamine-N5) methyltransferase activity
GSY65_RS02260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSY65_RS02280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY65_RS02285	COG3458	cephalosporin-C deacetylase activity
GSY65_RS02295	COG2226	methyltransferase
GSY65_RS02300	COG0366	Alpha amylase catalytic
GSY65_RS02310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GSY65_RS02315	COG1686	Belongs to the peptidase S11 family
GSY65_RS02320	COG2066	Belongs to the glutaminase family
GSY65_RS02325	COG1027	Aspartate ammonia-lyase
GSY65_RS02335	COG1113	amino acid transport
GSY65_RS02345	COG1968	undecaprenyl-diphosphatase activity
GSY65_RS02350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSY65_RS02355	COG1993	acr, cog1993
GSY65_RS02360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSY65_RS02390	COG1175	transmembrane transport
GSY65_RS02430	COG0366	Alpha amylase catalytic
GSY65_RS02440	COG3281	Trehalose synthase
GSY65_RS02445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GSY65_RS02460	COG0366	Alpha amylase catalytic
GSY65_RS02460	COG1874	Beta-galactosidase
GSY65_RS02495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSY65_RS02500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSY65_RS02510	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS02540	COG4213	ABC transporter substrate-binding protein
GSY65_RS02550	COG4213	ABC transporter substrate-binding protein
GSY65_RS02560	COG4214	carbohydrate transport
GSY65_RS02650	COG2124	cytochrome p450
GSY65_RS02655	COG2124	cytochrome p450
GSY65_RS02685	COG3321	synthase
GSY65_RS02685	COG0604	alcohol dehydrogenase
GSY65_RS02710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSY65_RS02725	COG4176	ABC-type proline glycine betaine transport system permease component
GSY65_RS02730	COG0517	IMP dehydrogenase activity
GSY65_RS02730	COG4175	Glycine betaine
GSY65_RS02750	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GSY65_RS02765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSY65_RS02770	COG2146	nitrite reductase [NAD(P)H] activity
GSY65_RS02785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GSY65_RS02820	COG1653	transport
GSY65_RS02825	COG0475	glutathione-regulated potassium exporter activity
GSY65_RS02860	COG1215	transferase activity, transferring glycosyl groups
GSY65_RS02895	COG1349	DNA-binding transcription factor activity
GSY65_RS02920	COG1940	carbohydrate kinase activity
GSY65_RS02925	COG3145	DNA-N1-methyladenine dioxygenase activity
GSY65_RS02930	COG2813	Specifically methylates the guanine in position
GSY65_RS02945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSY65_RS02950	COG1349	DNA-binding transcription factor activity
GSY65_RS02965	COG0738	Major facilitator superfamily
GSY65_RS02990	COG0445	tRNA wobble uridine modification
GSY65_RS02995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY65_RS03000	COG1660	Displays ATPase and GTPase activities
GSY65_RS03040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GSY65_RS03065	COG0204	Acyl-transferase
GSY65_RS03090	COG0584	glycerophosphoryl diester phosphodiesterase
GSY65_RS03110	COG1846	Transcriptional regulator
GSY65_RS03125	COG0671	phosphoesterase, PA-phosphatase related
GSY65_RS03135	COG1309	transcriptional regulator
GSY65_RS03155	COG0493	'glutamate synthase
GSY65_RS03160	COG0640	Transcriptional regulator
GSY65_RS03165	COG1902	pentaerythritol trinitrate reductase activity
GSY65_RS03170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GSY65_RS03210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GSY65_RS03225	COG2706	6-phosphogluconolactonase activity
GSY65_RS03240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSY65_RS03245	COG2151	metal-sulfur cluster biosynthetic enzyme
GSY65_RS03250	COG3396	Phenylacetate-CoA oxygenase
GSY65_RS03255	COG3460	Phenylacetate-CoA oxygenase
GSY65_RS03260	COG3396	Phenylacetate-CoA oxygenase
GSY65_RS03270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GSY65_RS03275	COG0531	amino acid
GSY65_RS03310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GSY65_RS03315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GSY65_RS03320	COG2080	2 iron, 2 sulfur cluster binding
GSY65_RS03355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GSY65_RS03375	COG1174	glycine betaine transport
GSY65_RS03395	COG0135	phosphoribosylanthranilate isomerase activity
GSY65_RS03400	COG1316	TRANSCRIPTIONal
GSY65_RS03425	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSY65_RS03430	COG1129	ABC transporter
GSY65_RS03435	COG2208	phosphoserine phosphatase activity
GSY65_RS03445	COG1295	ribonuclease BN
GSY65_RS03460	COG0432	Pfam Uncharacterised protein family UPF0047
GSY65_RS03465	COG2072	flavoprotein involved in K transport
GSY65_RS03485	COG1301	dicarboxylic acid transport
GSY65_RS03505	COG1132	(ABC) transporter
GSY65_RS03525	COG1946	Acyl-CoA thioesterase
GSY65_RS03535	COG2018	Roadblock/LC7 domain
GSY65_RS03575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSY65_RS03595	COG1940	carbohydrate kinase activity
GSY65_RS03610	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS03620	COG2080	2 iron, 2 sulfur cluster binding
GSY65_RS03625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GSY65_RS03630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GSY65_RS03635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GSY65_RS03635	COG3608	succinylglutamate desuccinylase aspartoacylase
GSY65_RS03685	COG2267	carboxylic ester hydrolase activity
GSY65_RS03700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GSY65_RS03705	COG0516	GMP reductase activity
GSY65_RS03705	COG0517	IMP dehydrogenase activity
GSY65_RS03750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSY65_RS03765	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSY65_RS03785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSY65_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS03840	COG1191	sigma factor activity
GSY65_RS03860	COG4257	antibiotic catabolic process
GSY65_RS03875	COG1609	Transcriptional regulator
GSY65_RS03895	COG0784	Response regulator, receiver
GSY65_RS03895	COG2205	protein histidine kinase activity
GSY65_RS03895	COG5002	protein histidine kinase activity
GSY65_RS03900	COG0395	ABC-type sugar transport system, permease component
GSY65_RS03905	COG1175	transmembrane transport
GSY65_RS03915	COG0366	Alpha amylase catalytic
GSY65_RS03920	COG1653	transport
GSY65_RS03930	COG1136	(ABC) transporter
GSY65_RS03940	COG1609	Transcriptional regulator
GSY65_RS03955	COG0395	ABC-type sugar transport system, permease component
GSY65_RS03970	COG2755	lipolytic protein G-D-S-L family
GSY65_RS04035	COG3866	Pectate lyase
GSY65_RS04060	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS04065	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS04080	COG3118	belongs to the thioredoxin family
GSY65_RS04080	COG0492	ferredoxin-NADP+ reductase activity
GSY65_RS04085	COG1793	dna ligase
GSY65_RS04110	COG2124	cytochrome p450
GSY65_RS04115	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS04125	COG0242	peptide deformylase activity
GSY65_RS04135	COG3442	glutamine amidotransferase
GSY65_RS04140	COG0205	6-phosphofructokinase activity
GSY65_RS04155	COG3275	phosphorelay sensor kinase activity
GSY65_RS04160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY65_RS04170	COG3279	Response regulator of the LytR AlgR family
GSY65_RS04180	COG1834	amidinotransferase
GSY65_RS04185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSY65_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS04205	COG0829	nickel cation binding
GSY65_RS04210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GSY65_RS04220	COG0804	urea catabolic process
GSY65_RS04225	COG0832	Belongs to the urease beta subunit family
GSY65_RS04230	COG0831	urea catabolic process
GSY65_RS04235	COG1309	transcriptional regulator
GSY65_RS04255	COG0740	serine-type endopeptidase activity
GSY65_RS04295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GSY65_RS04300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GSY65_RS04305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GSY65_RS04335	COG1136	(ABC) transporter
GSY65_RS04340	COG1136	(ABC) transporter
GSY65_RS04340	COG0577	efflux transmembrane transporter activity
GSY65_RS04375	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS04375	COG1454	alcohol dehydrogenase
GSY65_RS04410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GSY65_RS04420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GSY65_RS04440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GSY65_RS04575	COG1940	carbohydrate kinase activity
GSY65_RS04580	COG2188	Transcriptional regulator
GSY65_RS04585	COG1595	DNA-templated transcription, initiation
GSY65_RS04590	COG2267	carboxylic ester hydrolase activity
GSY65_RS04625	COG0626	cystathionine gamma-synthase activity
GSY65_RS04650	COG1522	sequence-specific DNA binding
GSY65_RS04655	COG0419	ATPase involved in DNA repair
GSY65_RS04660	COG0420	3'-5' exonuclease activity
GSY65_RS04665	COG1739	Uncharacterized protein family UPF0029
GSY65_RS04680	COG1832	CoA-binding protein
GSY65_RS04685	COG0589	response to stress
GSY65_RS04695	COG0542	response to heat
GSY65_RS04720	COG0110	maltose O-acetyltransferase activity
GSY65_RS04760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GSY65_RS04785	COG1968	undecaprenyl-diphosphatase activity
GSY65_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS04810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSY65_RS04825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GSY65_RS04840	COG2318	DinB family
GSY65_RS04855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GSY65_RS04860	COG4166	transmembrane transport
GSY65_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS04905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSY65_RS04925	COG3507	Belongs to the glycosyl hydrolase 43 family
GSY65_RS04935	COG0444	Belongs to the ABC transporter superfamily
GSY65_RS04940	COG0601	transmembrane transport
GSY65_RS04945	COG0747	negative chemotaxis
GSY65_RS04975	COG3848	Pyruvate phosphate dikinase
GSY65_RS04975	COG0574	Belongs to the PEP-utilizing enzyme family
GSY65_RS04995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSY65_RS05005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSY65_RS05015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GSY65_RS05020	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS05065	COG4689	acetoacetate decarboxylase
GSY65_RS05080	COG0174	glutamine synthetase
GSY65_RS05105	COG0583	DNA-binding transcription factor activity
GSY65_RS05155	COG0384	phenazine biosynthesis protein PhzF
GSY65_RS05180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSY65_RS05180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSY65_RS05190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSY65_RS05210	COG1716	ATPase activity
GSY65_RS05230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSY65_RS05260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSY65_RS05270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSY65_RS05295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GSY65_RS05300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSY65_RS05315	COG2018	Roadblock/LC7 domain
GSY65_RS05335	COG0531	amino acid
GSY65_RS05375	COG4336	lyase activity
GSY65_RS05380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GSY65_RS05385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GSY65_RS05390	COG1984	allophanate hydrolase subunit 2
GSY65_RS05395	COG2755	lipolytic protein G-D-S-L family
GSY65_RS05400	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS05430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY65_RS05435	COG2364	Membrane
GSY65_RS05445	COG2270	Major facilitator Superfamily
GSY65_RS05455	COG3030	protein affecting phage T7 exclusion by the F plasmid
GSY65_RS05460	COG1216	Glycosyl transferase, family 2
GSY65_RS05480	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS05485	COG1309	transcriptional regulator
GSY65_RS05525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GSY65_RS05530	COG0140	phosphoribosyl-ATP diphosphatase activity
GSY65_RS05535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GSY65_RS05540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSY65_RS05540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSY65_RS05545	COG3201	nicotinamide mononucleotide transporter
GSY65_RS05555	COG1090	epimerase
GSY65_RS05560	COG1940	carbohydrate kinase activity
GSY65_RS05560	COG1846	Transcriptional regulator
GSY65_RS05565	COG0738	Major facilitator superfamily
GSY65_RS05590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSY65_RS05600	COG2188	Transcriptional regulator
GSY65_RS05610	COG0531	amino acid
GSY65_RS05625	COG2390	Transcriptional regulator
GSY65_RS05630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GSY65_RS05635	COG2409	Drug exporters of the RND superfamily
GSY65_RS05645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSY65_RS05660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GSY65_RS05670	COG1758	RNA polymerase activity
GSY65_RS05675	COG0194	GDP metabolic process
GSY65_RS05685	COG0284	orotidine-5'-phosphate decarboxylase activity
GSY65_RS05690	COG0167	dihydroorotate dehydrogenase activity
GSY65_RS05695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GSY65_RS05700	COG0505	Belongs to the CarA family
GSY65_RS05710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GSY65_RS05715	COG0540	Belongs to the ATCase OTCase family
GSY65_RS05720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GSY65_RS05730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSY65_RS05735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GSY65_RS05740	COG0006	proline dipeptidase activity
GSY65_RS05750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GSY65_RS05755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSY65_RS05760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GSY65_RS05775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSY65_RS05780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GSY65_RS05785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GSY65_RS05790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSY65_RS05805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GSY65_RS05820	COG0124	histidyl-tRNA synthetase
GSY65_RS05830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GSY65_RS05835	COG1196	nuclear chromosome segregation
GSY65_RS05840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSY65_RS05845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSY65_RS05850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSY65_RS05855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSY65_RS05865	COG2255	four-way junction helicase activity
GSY65_RS05870	COG0632	four-way junction helicase activity
GSY65_RS05875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GSY65_RS05880	COG0217	transcriptional regulatory protein
GSY65_RS05885	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GSY65_RS05890	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GSY65_RS05900	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS05905	COG1560	Kdo2-lipid A biosynthetic process
GSY65_RS05930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GSY65_RS05945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSY65_RS05975	COG0395	ABC-type sugar transport system, permease component
GSY65_RS05980	COG1175	transmembrane transport
GSY65_RS06085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSY65_RS06085	COG1648	precorrin-2 dehydrogenase activity
GSY65_RS06090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GSY65_RS06105	COG1464	Belongs to the NlpA lipoprotein family
GSY65_RS06110	COG2011	ABC-type metal ion transport system permease component
GSY65_RS06115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GSY65_RS06140	COG0584	glycerophosphoryl diester phosphodiesterase
GSY65_RS06145	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS06145	COG0204	Acyl-transferase
GSY65_RS06155	COG0477	Major facilitator Superfamily
GSY65_RS06170	COG0165	Argininosuccinate lyase
GSY65_RS06205	COG1438	arginine binding
GSY65_RS06210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSY65_RS06215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GSY65_RS06220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GSY65_RS06225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GSY65_RS06260	COG0697	spore germination
GSY65_RS06270	COG1649	PFAM Uncharacterised BCR, COG1649
GSY65_RS06300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSY65_RS06300	COG0072	phenylalanine-tRNA ligase activity
GSY65_RS06305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GSY65_RS06310	COG5002	protein histidine kinase activity
GSY65_RS06315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSY65_RS06320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GSY65_RS06325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GSY65_RS06330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GSY65_RS06350	COG1404	Belongs to the peptidase S8 family
GSY65_RS06375	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS06380	COG0174	glutamine synthetase
GSY65_RS06390	COG0531	amino acid
GSY65_RS06395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GSY65_RS06425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSY65_RS06445	COG0564	pseudouridine synthase activity
GSY65_RS06490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSY65_RS06520	COG0545	Peptidyl-prolyl cis-trans isomerase
GSY65_RS06525	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GSY65_RS06535	COG1609	Transcriptional regulator
GSY65_RS06540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GSY65_RS06545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GSY65_RS06560	COG4122	O-methyltransferase activity
GSY65_RS06565	COG1222	aaa ATPase
GSY65_RS06590	COG1994	Peptidase M50
GSY65_RS06590	COG0517	IMP dehydrogenase activity
GSY65_RS06600	COG2197	response regulator
GSY65_RS06605	COG4166	transmembrane transport
GSY65_RS06610	COG4166	transmembrane transport
GSY65_RS06615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSY65_RS06625	COG0646	methionine synthase
GSY65_RS06625	COG1410	methionine synthase
GSY65_RS06630	COG1414	Transcriptional regulator
GSY65_RS06635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GSY65_RS06640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSY65_RS06645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GSY65_RS06655	COG2186	Transcriptional regulator
GSY65_RS06670	COG0215	cysteine-tRNA ligase activity
GSY65_RS06685	COG0588	phosphoglycerate mutase activity
GSY65_RS06690	COG0598	Magnesium transport protein CorA
GSY65_RS06700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS06705	COG0667	Aldo Keto reductase
GSY65_RS06750	COG0308	aminopeptidase N
GSY65_RS06755	COG3012	SEC-C Motif Domain Protein
GSY65_RS06760	COG2186	Transcriptional regulator
GSY65_RS06765	COG3265	gluconokinase activity
GSY65_RS06780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSY65_RS06785	COG3573	Dehydrogenase
GSY65_RS06795	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GSY65_RS06800	COG2149	membrane
GSY65_RS06840	COG3876	Protein conserved in bacteria
GSY65_RS06865	COG0789	Transcriptional regulator
GSY65_RS06880	COG0726	polysaccharide deacetylase
GSY65_RS06895	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS06905	COG0697	spore germination
GSY65_RS06945	COG2851	Citrate transporter
GSY65_RS06955	COG1309	transcriptional regulator
GSY65_RS06960	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GSY65_RS06985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GSY65_RS07000	COG1595	DNA-templated transcription, initiation
GSY65_RS07020	COG0515	serine threonine protein kinase
GSY65_RS07020	COG2815	serine threonine protein kinase
GSY65_RS07025	COG2755	lipolytic protein G-D-S-L family
GSY65_RS07045	COG1215	transferase activity, transferring glycosyl groups
GSY65_RS07050	COG0726	polysaccharide deacetylase
GSY65_RS07075	COG1725	Transcriptional regulator
GSY65_RS07115	COG0662	Cupin 2, conserved barrel domain protein
GSY65_RS07115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GSY65_RS07120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSY65_RS07125	COG0587	DNA-directed DNA polymerase activity
GSY65_RS07150	COG1799	cell septum assembly
GSY65_RS07155	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS07160	COG0477	Major facilitator Superfamily
GSY65_RS07170	COG0671	phosphoesterase, PA-phosphatase related
GSY65_RS07180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GSY65_RS07195	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS07210	COG0410	ABC transporter
GSY65_RS07215	COG1652	LysM domain
GSY65_RS07230	COG1160	GTP binding
GSY65_RS07240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GSY65_RS07260	COG3541	Predicted nucleotidyltransferase
GSY65_RS07265	COG3541	Predicted nucleotidyltransferase
GSY65_RS07275	COG0494	nUDIX hydrolase
GSY65_RS07280	COG1187	pseudouridine synthase activity
GSY65_RS07285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GSY65_RS07290	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GSY65_RS07305	COG0686	Belongs to the AlaDH PNT family
GSY65_RS07315	COG0494	nUDIX hydrolase
GSY65_RS07320	COG0504	CTP synthase activity
GSY65_RS07325	COG3387	PFAM Glycoside hydrolase 15-related
GSY65_RS07345	COG0497	DNA recombination
GSY65_RS07355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GSY65_RS07375	COG1120	ATPase activity
GSY65_RS07380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY65_RS07385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY65_RS07390	COG0647	UMP catabolic process
GSY65_RS07425	COG2094	Belongs to the DNA glycosylase MPG family
GSY65_RS07435	COG1881	PFAM PEBP family protein
GSY65_RS07455	COG1119	ATPase activity
GSY65_RS07470	COG2197	response regulator
GSY65_RS07490	COG0842	Transport permease protein
GSY65_RS07490	COG1131	(ABC) transporter
GSY65_RS07490	COG1716	ATPase activity
GSY65_RS07500	COG3830	Belongs to the UPF0237 family
GSY65_RS07500	COG0560	Phosphoserine phosphatase
GSY65_RS07525	COG2186	Transcriptional regulator
GSY65_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS07555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GSY65_RS07560	COG2261	transglycosylase associated protein
GSY65_RS07575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSY65_RS07580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY65_RS07600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GSY65_RS07620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GSY65_RS07650	COG3387	PFAM Glycoside hydrolase 15-related
GSY65_RS07690	COG1024	Enoyl-CoA hydratase
GSY65_RS07700	COG0488	(ABC) transporter
GSY65_RS07720	COG0235	Class ii aldolase
GSY65_RS07735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GSY65_RS07740	COG1492	cobalamin metabolic process
GSY65_RS07760	COG1797	cobyrinic acid a,c-diamide synthase activity
GSY65_RS07790	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GSY65_RS07805	COG1126	abc transporter atp-binding protein
GSY65_RS07810	COG0765	amino acid transport
GSY65_RS07820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GSY65_RS07830	COG0456	acetyltransferase
GSY65_RS07835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GSY65_RS07840	COG1917	Cupin 2, conserved barrel domain protein
GSY65_RS07845	COG5285	phytanoyl-CoA dioxygenase
GSY65_RS07855	COG1595	DNA-templated transcription, initiation
GSY65_RS07880	COG1414	Transcriptional regulator
GSY65_RS07885	COG0768	penicillin binding
GSY65_RS07890	COG2252	PERMEase
GSY65_RS07895	COG1595	DNA-templated transcription, initiation
GSY65_RS07915	COG4677	pectinesterase activity
GSY65_RS07920	COG4677	pectinesterase activity
GSY65_RS07930	COG2755	lipolytic protein G-D-S-L family
GSY65_RS07950	COG0673	inositol 2-dehydrogenase activity
GSY65_RS07955	COG0395	ABC-type sugar transport system, permease component
GSY65_RS07960	COG1175	transmembrane transport
GSY65_RS07970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY65_RS07995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY65_RS08000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSY65_RS08005	COG1349	DNA-binding transcription factor activity
GSY65_RS08020	COG0395	ABC-type sugar transport system, permease component
GSY65_RS08025	COG1063	alcohol dehydrogenase
GSY65_RS08040	COG1802	Transcriptional regulator
GSY65_RS08090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY65_RS08100	COG1595	DNA-templated transcription, initiation
GSY65_RS08110	COG2171	N-acyltransferase activity
GSY65_RS08115	COG3226	Transcriptional regulator
GSY65_RS08120	COG2076	Multidrug Resistance protein
GSY65_RS08130	COG2151	metal-sulfur cluster biosynthetic enzyme
GSY65_RS08135	COG0822	iron-sulfur transferase activity
GSY65_RS08140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSY65_RS08145	COG0396	ATPase activity
GSY65_RS08155	COG0719	Fe-S assembly protein
GSY65_RS08180	COG1612	heme a metabolic process
GSY65_RS08200	COG0109	protoheme IX farnesyltransferase activity
GSY65_RS08210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSY65_RS08225	COG0363	glucosamine-6-phosphate deaminase activity
GSY65_RS08240	COG0166	Belongs to the GPI family
GSY65_RS08250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSY65_RS08255	COG0149	triose-phosphate isomerase activity
GSY65_RS08260	COG0126	phosphoglycerate kinase activity
GSY65_RS08265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GSY65_RS08275	COG1481	regulation of sporulation
GSY65_RS08280	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GSY65_RS08285	COG1660	Displays ATPase and GTPase activities
GSY65_RS08290	COG0322	excinuclease ABC activity
GSY65_RS08295	COG2197	response regulator
GSY65_RS08300	COG4585	Histidine kinase
GSY65_RS08315	COG2201	protein-glutamate methylesterase activity
GSY65_RS08330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GSY65_RS08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY65_RS08350	COG0765	amino acid transport
GSY65_RS08355	COG1126	abc transporter atp-binding protein
GSY65_RS08360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GSY65_RS08365	COG1619	proteins homologs of microcin C7 resistance protein MccF
GSY65_RS08370	COG0477	Major facilitator Superfamily
GSY65_RS08375	COG0387	Pfam Sodium calcium exchanger
GSY65_RS08380	COG0861	Integral membrane protein TerC family
GSY65_RS08395	COG0556	nucleotide-excision repair
GSY65_RS08405	COG0584	glycerophosphoryl diester phosphodiesterase
GSY65_RS08410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSY65_RS08420	COG2313	pseudouridylate synthase activity
GSY65_RS08425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GSY65_RS08425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GSY65_RS08430	COG2226	methyltransferase
GSY65_RS08435	COG0598	Magnesium transport protein CorA
GSY65_RS08465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSY65_RS08470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY65_RS08500	COG1132	(ABC) transporter
GSY65_RS08540	COG2267	carboxylic ester hydrolase activity
GSY65_RS08580	COG0237	dephospho-CoA kinase activity
GSY65_RS08590	COG0539	negative regulation of cytoplasmic translation
GSY65_RS08600	COG1643	Atp-dependent helicase
GSY65_RS08635	COG2050	protein possibly involved in aromatic compounds catabolism
GSY65_RS08655	COG0559	Belongs to the binding-protein-dependent transport system permease family
GSY65_RS08665	COG0411	ABC transporter
GSY65_RS08670	COG0410	ABC transporter
GSY65_RS08690	COG0469	pyruvate kinase activity
GSY65_RS08700	COG0737	Belongs to the 5'-nucleotidase family
GSY65_RS08720	COG4566	intracellular signal transduction
GSY65_RS08725	COG0287	Prephenate dehydrogenase
GSY65_RS08725	COG1605	Chorismate mutase
GSY65_RS08735	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS08765	COG0183	Belongs to the thiolase family
GSY65_RS08770	COG1309	transcriptional regulator
GSY65_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS08780	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS08785	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS08790	COG2304	oxidoreductase activity
GSY65_RS08805	COG0070	glutamate synthase
GSY65_RS08805	COG0069	glutamate synthase activity
GSY65_RS08805	COG0067	glutamate synthase
GSY65_RS08835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GSY65_RS08840	COG2301	Belongs to the HpcH HpaI aldolase family
GSY65_RS08845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GSY65_RS08855	COG0159	tryptophan synthase activity
GSY65_RS08860	COG0133	tryptophan synthase activity
GSY65_RS08870	COG0134	indole-3-glycerol-phosphate synthase activity
GSY65_RS08895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GSY65_RS08915	COG0107	imidazoleglycerol-phosphate synthase activity
GSY65_RS08920	COG0251	oxidation-reduction process
GSY65_RS08925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GSY65_RS08930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GSY65_RS08935	COG0131	Imidazoleglycerol-phosphate dehydratase
GSY65_RS08940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSY65_RS08985	COG1432	Conserved Protein
GSY65_RS08990	COG0587	DNA-directed DNA polymerase activity
GSY65_RS09045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GSY65_RS09050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GSY65_RS09055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GSY65_RS09060	COG3599	regulation of cell shape
GSY65_RS09070	COG1799	cell septum assembly
GSY65_RS09085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GSY65_RS09090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GSY65_RS09095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSY65_RS09105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GSY65_RS09110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSY65_RS09120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GSY65_RS09135	COG0275	rRNA processing
GSY65_RS09145	COG0714	Associated with various cellular activities
GSY65_RS09165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GSY65_RS09175	COG1121	(ABC) transporter
GSY65_RS09185	COG1309	transcriptional regulator
GSY65_RS09205	COG0352	thiamine-phosphate diphosphorylase activity
GSY65_RS09225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY65_RS09225	COG2022	thiamine diphosphate biosynthetic process
GSY65_RS09235	COG2022	thiamine diphosphate biosynthetic process
GSY65_RS09240	COG2815	serine threonine protein kinase
GSY65_RS09240	COG0515	serine threonine protein kinase
GSY65_RS09245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GSY65_RS09250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSY65_RS09255	COG2193	ferroxidase activity
GSY65_RS09260	COG0243	molybdopterin cofactor binding
GSY65_RS09270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GSY65_RS09285	COG0205	6-phosphofructokinase activity
GSY65_RS09295	COG4585	Histidine kinase
GSY65_RS09320	COG1940	carbohydrate kinase activity
GSY65_RS09330	COG0003	Pfam Anion-transporting ATPase
GSY65_RS09355	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS09405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSY65_RS09410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GSY65_RS09415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GSY65_RS09420	COG0723	plastoquinol--plastocyanin reductase activity
GSY65_RS09425	COG2010	Cytochrome c
GSY65_RS09430	COG1845	cytochrome c oxidase, subunit III
GSY65_RS09450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GSY65_RS09455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GSY65_RS09490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GSY65_RS09500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSY65_RS09505	COG2197	response regulator
GSY65_RS09510	COG4585	Histidine kinase
GSY65_RS09530	COG2226	methyltransferase
GSY65_RS09550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GSY65_RS09555	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GSY65_RS09555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GSY65_RS09570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GSY65_RS09580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GSY65_RS09585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSY65_RS09590	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSY65_RS09600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GSY65_RS09650	COG0321	lipoyl(octanoyl) transferase activity
GSY65_RS09655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GSY65_RS09675	COG0174	glutamine synthetase
GSY65_RS09685	COG0477	Major facilitator Superfamily
GSY65_RS09705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSY65_RS09715	COG0501	Belongs to the peptidase M48B family
GSY65_RS09765	COG0745	RESPONSE REGULATOR receiver
GSY65_RS09795	COG1309	transcriptional regulator
GSY65_RS09820	COG0366	Alpha amylase catalytic
GSY65_RS09825	COG3833	ABC-type maltose transport systems, permease component
GSY65_RS09830	COG1175	transmembrane transport
GSY65_RS09840	COG1609	Transcriptional regulator
GSY65_RS09850	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GSY65_RS09855	COG0174	glutamine synthetase
GSY65_RS09875	COG2814	Major facilitator Superfamily
GSY65_RS09890	COG0477	Major facilitator Superfamily
GSY65_RS09895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GSY65_RS09915	COG1994	Peptidase M50
GSY65_RS09965	COG0384	phenazine biosynthesis protein PhzF
GSY65_RS09970	COG2822	iron ion transport
GSY65_RS09975	COG2837	iron assimilation
GSY65_RS09980	COG0672	)-iron permease
GSY65_RS10010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSY65_RS10015	COG2814	Major facilitator Superfamily
GSY65_RS10025	COG3540	Alkaline phosphatase
GSY65_RS10035	COG0667	Aldo Keto reductase
GSY65_RS10045	COG2259	Doxx family
GSY65_RS10055	COG2409	Drug exporters of the RND superfamily
GSY65_RS10060	COG4585	Histidine kinase
GSY65_RS10065	COG2197	response regulator
GSY65_RS10070	COG3940	Belongs to the glycosyl hydrolase 43 family
GSY65_RS10075	COG3940	Belongs to the glycosyl hydrolase 43 family
GSY65_RS10085	COG1201	RNA secondary structure unwinding
GSY65_RS10240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSY65_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS10265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GSY65_RS10270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSY65_RS10280	COG0367	asparagine synthase
GSY65_RS10285	COG2272	Belongs to the type-B carboxylesterase lipase family
GSY65_RS10290	COG2146	nitrite reductase [NAD(P)H] activity
GSY65_RS10290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSY65_RS10300	COG0243	molybdopterin cofactor binding
GSY65_RS10320	COG2130	NADP-dependent
GSY65_RS10330	COG1902	pentaerythritol trinitrate reductase activity
GSY65_RS10380	COG3022	response to hydroperoxide
GSY65_RS10385	COG0328	RNA-DNA hybrid ribonuclease activity
GSY65_RS10385	COG0406	alpha-ribazole phosphatase activity
GSY65_RS10395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GSY65_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS10435	COG2247	cell wall binding repeat
GSY65_RS10435	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSY65_RS10445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS10465	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS10470	COG1309	transcriptional regulator
GSY65_RS10510	COG3845	ABC transporter
GSY65_RS10545	COG0183	Belongs to the thiolase family
GSY65_RS10555	COG2124	cytochrome p450
GSY65_RS10705	COG0586	Pfam SNARE associated Golgi protein
GSY65_RS10715	COG1358	cellular component organization or biogenesis
GSY65_RS10760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GSY65_RS10765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSY65_RS10775	COG0477	Major facilitator Superfamily
GSY65_RS10780	COG1309	transcriptional regulator
GSY65_RS10795	COG0667	Aldo Keto reductase
GSY65_RS10800	COG0789	Transcriptional regulator
GSY65_RS10820	COG1741	Belongs to the pirin family
GSY65_RS10835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSY65_RS10840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSY65_RS10845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSY65_RS10895	COG2130	NADP-dependent
GSY65_RS10905	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSY65_RS10910	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSY65_RS10920	COG1879	ABC-type sugar transport system periplasmic component
GSY65_RS10925	COG1609	Transcriptional regulator
GSY65_RS10960	COG1129	ABC transporter
GSY65_RS10965	COG4214	carbohydrate transport
GSY65_RS10975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSY65_RS11010	COG3386	PFAM SMP-30 Gluconolaconase
GSY65_RS11015	COG1414	Transcriptional regulator
GSY65_RS11050	COG4981	capsule polysaccharide biosynthetic process
GSY65_RS11070	COG1663	tetraacyldisaccharide 4'-kinase activity
GSY65_RS11070	COG2835	tetraacyldisaccharide 4'-kinase activity
GSY65_RS11110	COG2186	Transcriptional regulator
GSY65_RS11115	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS11120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GSY65_RS11120	COG0825	malonyl-CoA metabolic process
GSY65_RS11145	COG0641	radical SAM
GSY65_RS11160	COG3629	intracellular signal transduction
GSY65_RS11160	COG3903	Transcriptional regulator
GSY65_RS11170	COG1053	succinate dehydrogenase
GSY65_RS11180	COG0477	Major facilitator Superfamily
GSY65_RS11195	COG0667	Aldo Keto reductase
GSY65_RS11200	COG0583	DNA-binding transcription factor activity
GSY65_RS11215	COG2409	Drug exporters of the RND superfamily
GSY65_RS11240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSY65_RS11245	COG0019	diaminopimelate decarboxylase activity
GSY65_RS11250	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS11260	COG0738	Major facilitator superfamily
GSY65_RS11270	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GSY65_RS11295	COG4585	Histidine kinase
GSY65_RS11300	COG2197	response regulator
GSY65_RS11315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSY65_RS11320	COG2409	Drug exporters of the RND superfamily
GSY65_RS11330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GSY65_RS11330	COG0674	pyruvate-flavodoxin oxidoreductase activity
GSY65_RS11335	COG1013	pyruvate-flavodoxin oxidoreductase activity
GSY65_RS11385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSY65_RS11390	COG3321	synthase
GSY65_RS11390	COG0604	alcohol dehydrogenase
GSY65_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS11430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSY65_RS11495	COG2319	Wd-40 repeat
GSY65_RS11495	COG4249	Peptidase C14 caspase catalytic subunit p20
GSY65_RS11535	COG0515	serine threonine protein kinase
GSY65_RS11575	COG1475	DNA binding
GSY65_RS11665	COG1070	Carbohydrate kinase
GSY65_RS11680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSY65_RS11685	COG0358	DNA primase activity
GSY65_RS11695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GSY65_RS11705	COG2949	membrane
GSY65_RS11720	COG0243	molybdopterin cofactor binding
GSY65_RS11735	COG0701	Predicted permease
GSY65_RS11760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSY65_RS11765	COG2146	nitrite reductase [NAD(P)H] activity
GSY65_RS11765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSY65_RS11775	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS11785	COG1819	glycosyl
GSY65_RS11800	COG0574	Belongs to the PEP-utilizing enzyme family
GSY65_RS11800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSY65_RS11805	COG1940	carbohydrate kinase activity
GSY65_RS11805	COG1846	Transcriptional regulator
GSY65_RS11840	COG3866	Pectate lyase
GSY65_RS11870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GSY65_RS11880	COG0423	glycine-tRNA ligase activity
GSY65_RS11885	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSY65_RS11885	COG3443	Belongs to the bacterial solute-binding protein 9 family
GSY65_RS11890	COG1121	(ABC) transporter
GSY65_RS11895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSY65_RS11910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSY65_RS11915	COG1381	Involved in DNA repair and RecF pathway recombination
GSY65_RS11925	COG3629	intracellular signal transduction
GSY65_RS11925	COG3903	Transcriptional regulator
GSY65_RS11940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY65_RS11950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSY65_RS11980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GSY65_RS12005	COG2315	Protein conserved in bacteria
GSY65_RS12015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GSY65_RS12025	COG1414	Transcriptional regulator
GSY65_RS12030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY65_RS12035	COG4948	Mandelate Racemase Muconate Lactonizing
GSY65_RS12050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSY65_RS12055	COG1234	tRNA 3'-trailer cleavage
GSY65_RS12060	COG0537	adenosine 5'-monophosphoramidase activity
GSY65_RS12065	COG4946	Tricorn protease homolog
GSY65_RS12065	COG0793	Belongs to the peptidase S41A family
GSY65_RS12085	COG0484	heat shock protein binding
GSY65_RS12090	COG1420	regulation of RNA biosynthetic process
GSY65_RS12145	COG0481	GTPase activity
GSY65_RS12150	COG0268	Binds directly to 16S ribosomal RNA
GSY65_RS12175	COG1555	photosystem II stabilization
GSY65_RS12180	COG1307	EDD domain protein, DegV family
GSY65_RS12190	COG0495	leucyl-tRNA aminoacylation
GSY65_RS12200	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GSY65_RS12220	COG0588	phosphoglycerate mutase activity
GSY65_RS12225	COG0799	negative regulation of ribosome biogenesis
GSY65_RS12235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GSY65_RS12240	COG0501	Belongs to the peptidase M48B family
GSY65_RS12255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GSY65_RS12265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GSY65_RS12275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GSY65_RS12280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GSY65_RS12285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GSY65_RS12295	COG1530	ribonuclease E activity
GSY65_RS12330	COG0772	Belongs to the SEDS family
GSY65_RS12335	COG0768	penicillin binding
GSY65_RS12350	COG1077	Cell shape determining protein MreB Mrl
GSY65_RS12355	COG0105	UTP biosynthetic process
GSY65_RS12365	COG0285	dihydrofolate synthase activity
GSY65_RS12370	COG0525	valine-tRNA ligase activity
GSY65_RS12385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GSY65_RS12390	COG0740	serine-type endopeptidase activity
GSY65_RS12395	COG0740	serine-type endopeptidase activity
GSY65_RS12400	COG0544	peptidyl-prolyl cis-trans isomerase activity
GSY65_RS12420	COG3594	Acyltransferase
GSY65_RS12435	COG4552	Acetyltransferase involved in intracellular survival and related
GSY65_RS12460	COG1113	amino acid transport
GSY65_RS12475	COG1113	amino acid transport
GSY65_RS12490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GSY65_RS12560	COG1846	Transcriptional regulator
GSY65_RS12585	COG0668	transmembrane transport
GSY65_RS12610	COG1486	melibiose metabolic process
GSY65_RS12625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY65_RS12640	COG0631	protein serine/threonine phosphatase activity
GSY65_RS12655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GSY65_RS12685	COG0629	single-stranded DNA binding
GSY65_RS12690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GSY65_RS12705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSY65_RS12720	COG2304	oxidoreductase activity
GSY65_RS12770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GSY65_RS12780	COG0728	peptidoglycan biosynthetic process
GSY65_RS12815	COG0492	ferredoxin-NADP+ reductase activity
GSY65_RS12860	COG1131	(ABC) transporter
GSY65_RS12870	COG3962	Belongs to the TPP enzyme family
GSY65_RS12875	COG3718	enzyme involved in inositol metabolism
GSY65_RS12885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY65_RS12910	COG2409	Drug exporters of the RND superfamily
GSY65_RS12935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GSY65_RS12955	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS12965	COG1609	Transcriptional regulator
GSY65_RS12970	COG1129	ABC transporter
GSY65_RS12975	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSY65_RS12980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY65_RS12985	COG1869	D-ribose catabolic process
GSY65_RS13030	COG1674	ftsk spoiiie
GSY65_RS13040	COG3467	pyridoxamine 5'-phosphate
GSY65_RS13045	COG1840	ABC-type Fe3 transport system, periplasmic component
GSY65_RS13055	COG3842	ATPase activity
GSY65_RS13105	COG0673	inositol 2-dehydrogenase activity
GSY65_RS13125	COG2890	protein-(glutamine-N5) methyltransferase activity
GSY65_RS13135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY65_RS13135	COG0723	plastoquinol--plastocyanin reductase activity
GSY65_RS13145	COG3340	Belongs to the peptidase S51 family
GSY65_RS13150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GSY65_RS13155	COG1472	Belongs to the glycosyl hydrolase 3 family
GSY65_RS13200	COG1131	(ABC) transporter
GSY65_RS13215	COG3973	AAA domain
GSY65_RS13230	COG0640	Transcriptional regulator
GSY65_RS13235	COG0346	lactoylglutathione lyase activity
GSY65_RS13260	COG2356	endonuclease I
GSY65_RS13270	COG0028	Belongs to the TPP enzyme family
GSY65_RS13290	COG1946	Acyl-CoA thioesterase
GSY65_RS13300	COG1309	transcriptional regulator
GSY65_RS13305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSY65_RS13320	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS13335	COG0076	glutamate decarboxylase activity
GSY65_RS13340	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GSY65_RS13365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSY65_RS13370	COG0589	response to stress
GSY65_RS13380	COG4977	sequence-specific DNA binding
GSY65_RS13385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GSY65_RS13400	COG1653	transport
GSY65_RS13410	COG0395	ABC-type sugar transport system, permease component
GSY65_RS13445	COG1653	transport
GSY65_RS13455	COG0745	RESPONSE REGULATOR receiver
GSY65_RS13465	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GSY65_RS13480	COG0406	alpha-ribazole phosphatase activity
GSY65_RS13550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS13565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY65_RS13570	COG0765	amino acid transport
GSY65_RS13575	COG0765	amino acid transport
GSY65_RS13580	COG1126	abc transporter atp-binding protein
GSY65_RS13610	COG3397	chitin binding
GSY65_RS13665	COG1940	carbohydrate kinase activity
GSY65_RS13670	COG0673	inositol 2-dehydrogenase activity
GSY65_RS13680	COG0706	membrane insertase activity
GSY65_RS13690	COG3764	Sortase (surface protein transpeptidase)
GSY65_RS13745	COG0071	Belongs to the small heat shock protein (HSP20) family
GSY65_RS13765	COG2733	membrane
GSY65_RS13795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GSY65_RS13830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GSY65_RS13840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GSY65_RS13845	COG1263	PTS System
GSY65_RS13845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY65_RS13870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GSY65_RS13875	COG1263	PTS System
GSY65_RS13875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY65_RS13880	COG1234	tRNA 3'-trailer cleavage
GSY65_RS13915	COG1113	amino acid transport
GSY65_RS13925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GSY65_RS13935	COG1335	isochorismatase
GSY65_RS13945	COG3291	Pkd domain containing protein
GSY65_RS13945	COG4412	M6 family metalloprotease domain protein
GSY65_RS13970	COG0277	FAD linked oxidase domain protein
GSY65_RS13980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GSY65_RS13990	COG1174	glycine betaine transport
GSY65_RS14000	COG1174	glycine betaine transport
GSY65_RS14040	COG1061	Type III restriction enzyme res subunit
GSY65_RS14045	COG3654	unkown
GSY65_RS14070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GSY65_RS14085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GSY65_RS14090	COG0395	ABC-type sugar transport system, permease component
GSY65_RS14110	COG1678	Uncharacterized ACR, COG1678
GSY65_RS14115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSY65_RS14120	COG0776	regulation of translation
GSY65_RS14130	COG3973	AAA domain
GSY65_RS14155	COG2223	nitrite transmembrane transporter activity
GSY65_RS14195	COG0726	polysaccharide deacetylase
GSY65_RS14205	COG0583	DNA-binding transcription factor activity
GSY65_RS14230	COG1501	Belongs to the glycosyl hydrolase 31 family
GSY65_RS14235	COG1609	Transcriptional regulator
GSY65_RS14245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GSY65_RS14250	COG0793	Belongs to the peptidase S41A family
GSY65_RS14260	COG2884	Cell division ATP-binding protein ftsE
GSY65_RS14275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GSY65_RS14280	COG0515	serine threonine protein kinase
GSY65_RS14290	COG0515	serine threonine protein kinase
GSY65_RS14295	COG1674	ftsk spoiiie
GSY65_RS14300	COG1653	transport
GSY65_RS14305	COG1175	transmembrane transport
GSY65_RS14310	COG0395	ABC-type sugar transport system, permease component
GSY65_RS14315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSY65_RS14315	COG0463	Glycosyl transferase, family 2
GSY65_RS14320	COG1216	Glycosyl transferase, family 2
GSY65_RS14330	COG1764	response to oxidative stress
GSY65_RS14335	COG1846	Transcriptional regulator
GSY65_RS14340	COG1216	Glycosyl transferase, family 2
GSY65_RS14345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GSY65_RS14385	COG1134	teichoic acid transport
GSY65_RS14390	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS14395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSY65_RS14400	COG0515	serine threonine protein kinase
GSY65_RS14400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GSY65_RS14410	COG2902	Dehydrogenase
GSY65_RS14430	COG0653	protein targeting
GSY65_RS14440	COG3214	Protein conserved in bacteria
GSY65_RS14445	COG2197	response regulator
GSY65_RS14450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GSY65_RS14460	COG0823	Involved in the tonB-independent uptake of proteins
GSY65_RS14465	COG5002	protein histidine kinase activity
GSY65_RS14465	COG5000	phosphorelay sensor kinase activity
GSY65_RS14470	COG0745	RESPONSE REGULATOR receiver
GSY65_RS14475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GSY65_RS14495	COG0714	Associated with various cellular activities
GSY65_RS14535	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GSY65_RS14545	COG1482	cell wall glycoprotein biosynthetic process
GSY65_RS14555	COG2835	tetraacyldisaccharide 4'-kinase activity
GSY65_RS14560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSY65_RS14600	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GSY65_RS14600	COG0778	Nitroreductase
GSY65_RS14610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSY65_RS14625	COG1316	TRANSCRIPTIONal
GSY65_RS14630	COG1316	TRANSCRIPTIONal
GSY65_RS14635	COG1316	TRANSCRIPTIONal
GSY65_RS14645	COG1316	TRANSCRIPTIONal
GSY65_RS14655	COG1316	TRANSCRIPTIONal
GSY65_RS14670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GSY65_RS14695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GSY65_RS14710	COG2205	protein histidine kinase activity
GSY65_RS14715	COG0745	RESPONSE REGULATOR receiver
GSY65_RS14720	COG3104	oligopeptide transport
GSY65_RS14745	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY65_RS14750	COG1191	sigma factor activity
GSY65_RS14755	COG1228	amidohydrolase
GSY65_RS14765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY65_RS14770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GSY65_RS14835	COG0183	Belongs to the thiolase family
GSY65_RS14905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSY65_RS14915	COG3629	intracellular signal transduction
GSY65_RS14935	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY65_RS14975	COG0604	alcohol dehydrogenase
GSY65_RS14980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GSY65_RS14985	COG0477	Major facilitator Superfamily
GSY65_RS14990	COG2132	Multicopper oxidase
GSY65_RS15000	COG4221	oxidoreductase activity
GSY65_RS15025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GSY65_RS15035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSY65_RS15060	COG0367	asparagine synthase
GSY65_RS15075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GSY65_RS15095	COG1136	(ABC) transporter
GSY65_RS15100	COG0577	efflux transmembrane transporter activity
GSY65_RS15105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GSY65_RS15110	COG1252	NADH dehydrogenase
GSY65_RS15140	COG0148	phosphopyruvate hydratase activity
GSY65_RS15155	COG2124	cytochrome p450
GSY65_RS15225	COG0577	efflux transmembrane transporter activity
GSY65_RS15230	COG1136	(ABC) transporter
GSY65_RS15235	COG0477	Major facilitator Superfamily
GSY65_RS15245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY65_RS15290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GSY65_RS15295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GSY65_RS15300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GSY65_RS15305	COG0193	aminoacyl-tRNA hydrolase activity
GSY65_RS15315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GSY65_RS15325	COG1309	transcriptional regulator
GSY65_RS15335	COG0477	Major facilitator Superfamily
GSY65_RS15340	COG4106	trans-aconitate 2-methyltransferase activity
GSY65_RS15345	COG1846	Transcriptional regulator
GSY65_RS15350	COG2197	response regulator
GSY65_RS15375	COG1404	Belongs to the peptidase S8 family
GSY65_RS15385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GSY65_RS15430	COG0488	(ABC) transporter
GSY65_RS15440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GSY65_RS15450	COG3583	domain protein
GSY65_RS15450	COG3584	3D domain protein
GSY65_RS15455	COG0084	hydrolase, TatD family'
GSY65_RS15510	COG1764	response to oxidative stress
GSY65_RS15515	COG1846	Transcriptional regulator
GSY65_RS15520	COG1122	ATPase activity
GSY65_RS15530	COG0310	cobalt ion transport
GSY65_RS15550	COG0542	response to heat
GSY65_RS15555	COG2318	DinB family
GSY65_RS15560	COG2409	Drug exporters of the RND superfamily
GSY65_RS15570	COG4946	Tricorn protease homolog
GSY65_RS15570	COG0793	Belongs to the peptidase S41A family
GSY65_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS15585	COG2267	carboxylic ester hydrolase activity
GSY65_RS15590	COG2072	flavoprotein involved in K transport
GSY65_RS15600	COG0708	Exodeoxyribonuclease III
GSY65_RS15630	COG0315	cyclic pyranopterin monophosphate synthase activity
GSY65_RS15630	COG0521	Mo-molybdopterin cofactor biosynthetic process
GSY65_RS15635	COG0315	cyclic pyranopterin monophosphate synthase activity
GSY65_RS15645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSY65_RS15650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GSY65_RS15675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GSY65_RS15685	COG1970	mechanosensitive ion channel activity
GSY65_RS15720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY65_RS15720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSY65_RS15720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSY65_RS15750	COG1247	-acetyltransferase
GSY65_RS15755	COG3384	dioxygenase
GSY65_RS15760	COG1846	Transcriptional regulator
GSY65_RS15780	COG1414	Transcriptional regulator
GSY65_RS15795	COG4555	ABC transporter
GSY65_RS15885	COG0386	Belongs to the glutathione peroxidase family
GSY65_RS15900	COG1686	Belongs to the peptidase S11 family
GSY65_RS15960	COG1396	sequence-specific DNA binding
GSY65_RS15975	COG2186	Transcriptional regulator
GSY65_RS16010	COG2226	methyltransferase
GSY65_RS16035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GSY65_RS16040	COG4412	M6 family metalloprotease domain protein
GSY65_RS16040	COG3291	Pkd domain containing protein
GSY65_RS16065	COG2226	methyltransferase
GSY65_RS16110	COG2197	response regulator
GSY65_RS16125	COG3629	intracellular signal transduction
GSY65_RS16125	COG3903	Transcriptional regulator
GSY65_RS16150	COG1024	Enoyl-CoA hydratase
GSY65_RS16185	COG0515	serine threonine protein kinase
GSY65_RS16185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GSY65_RS16195	COG1309	transcriptional regulator
GSY65_RS16205	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS16245	COG2072	flavoprotein involved in K transport
GSY65_RS16255	COG1024	Enoyl-CoA hydratase
GSY65_RS16290	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS16295	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS16310	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS16315	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS16325	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS16335	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY65_RS16385	COG0596	Alpha beta hydrolase
GSY65_RS16385	COG2945	thiolester hydrolase activity
GSY65_RS16395	COG4821	SIS domain
GSY65_RS16425	COG0259	pyridoxamine-phosphate oxidase activity
GSY65_RS16435	COG1024	Enoyl-CoA hydratase
GSY65_RS16440	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS16455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSY65_RS16480	COG2197	response regulator
GSY65_RS16485	COG4585	Histidine kinase
GSY65_RS16495	COG0577	efflux transmembrane transporter activity
GSY65_RS16495	COG1136	(ABC) transporter
GSY65_RS16500	COG0247	lactate metabolic process
GSY65_RS16500	COG0277	FAD linked oxidase domain protein
GSY65_RS16520	COG2124	cytochrome p450
GSY65_RS16525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GSY65_RS16535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GSY65_RS16560	COG0667	Aldo Keto reductase
GSY65_RS16605	COG2252	PERMEase
GSY65_RS16615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GSY65_RS16650	COG2814	Major facilitator Superfamily
GSY65_RS16660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GSY65_RS16665	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GSY65_RS16670	COG1278	Cold shock
GSY65_RS16710	COG1061	Type III restriction enzyme res subunit
GSY65_RS16720	COG3973	AAA domain
GSY65_RS16770	COG1733	regulation of RNA biosynthetic process
GSY65_RS16790	COG1737	Transcriptional regulator
GSY65_RS16795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GSY65_RS16825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSY65_RS16845	COG0459	protein refolding
GSY65_RS16850	COG1278	Cold shock
GSY65_RS16865	COG0463	Glycosyl transferase, family 2
GSY65_RS16885	COG1653	transport
GSY65_RS16900	COG1105	Belongs to the carbohydrate kinase PfkB family
GSY65_RS16920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GSY65_RS16950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY65_RS16950	COG0723	plastoquinol--plastocyanin reductase activity
GSY65_RS17020	COG3842	ATPase activity
GSY65_RS17040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSY65_RS17045	COG0215	cysteine-tRNA ligase activity
GSY65_RS17050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GSY65_RS17055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GSY65_RS17060	COG1329	Transcriptional regulator
GSY65_RS17080	COG5002	protein histidine kinase activity
GSY65_RS17095	COG0588	phosphoglycerate mutase activity
GSY65_RS17110	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS17165	COG1309	transcriptional regulator
GSY65_RS17195	COG4552	Acetyltransferase involved in intracellular survival and related
GSY65_RS17210	COG1490	D-aminoacyl-tRNA deacylase activity
GSY65_RS17225	COG3485	protocatechuate 3,4-dioxygenase
GSY65_RS17250	COG2897	thiosulfate sulfurtransferase activity
GSY65_RS17275	COG0745	RESPONSE REGULATOR receiver
GSY65_RS17280	COG1609	Transcriptional regulator
GSY65_RS17285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSY65_RS17295	COG0745	RESPONSE REGULATOR receiver
GSY65_RS17305	COG2207	Transcriptional regulator
GSY65_RS17305	COG3708	Transcriptional regulator
GSY65_RS17310	COG0737	Belongs to the 5'-nucleotidase family
GSY65_RS17315	COG0456	acetyltransferase
GSY65_RS17320	COG1725	Transcriptional regulator
GSY65_RS17340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GSY65_RS17360	COG1937	Protein conserved in bacteria
GSY65_RS17370	COG0306	phosphate transporter
GSY65_RS17375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSY65_RS17395	COG0277	FAD linked oxidase domain protein
GSY65_RS17400	COG0671	phosphoesterase, PA-phosphatase related
GSY65_RS17405	COG0739	heme binding
GSY65_RS17405	COG0741	lytic transglycosylase activity
GSY65_RS17405	COG1196	nuclear chromosome segregation
GSY65_RS17495	COG1252	NADH dehydrogenase
GSY65_RS17520	COG0579	oxidoreductase
GSY65_RS17525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GSY65_RS17550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSY65_RS17560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSY65_RS17560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSY65_RS17600	COG0513	Belongs to the DEAD box helicase family
GSY65_RS17635	COG1643	Atp-dependent helicase
GSY65_RS17660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GSY65_RS17670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GSY65_RS17690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSY65_RS17695	COG0047	phosphoribosylformylglycinamidine synthase activity
GSY65_RS17700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSY65_RS17735	COG2197	response regulator
GSY65_RS17745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GSY65_RS17760	COG0151	Belongs to the GarS family
GSY65_RS17785	COG2814	Major facilitator Superfamily
GSY65_RS17795	COG0490	domain, Protein
GSY65_RS17825	COG1276	copper resistance
GSY65_RS17825	COG2372	response to copper ion
GSY65_RS17870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GSY65_RS17900	COG1191	sigma factor activity
GSY65_RS17910	COG1191	sigma factor activity
GSY65_RS17920	COG1846	Transcriptional regulator
GSY65_RS17930	COG2353	YceI-like domain
GSY65_RS17935	COG3467	pyridoxamine 5'-phosphate
GSY65_RS17945	COG0477	Major facilitator Superfamily
GSY65_RS17950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GSY65_RS17960	COG2205	protein histidine kinase activity
GSY65_RS17965	COG0745	RESPONSE REGULATOR receiver
GSY65_RS17970	COG2329	Antibiotic biosynthesis monooxygenase
GSY65_RS18010	COG0784	Response regulator, receiver
GSY65_RS18015	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS18020	COG1595	DNA-templated transcription, initiation
GSY65_RS18095	COG0653	protein targeting
GSY65_RS18115	COG0006	proline dipeptidase activity
GSY65_RS18120	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GSY65_RS18145	COG1999	signal sequence binding
GSY65_RS18160	COG2837	iron assimilation
GSY65_RS18170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GSY65_RS18175	COG0561	phosphatase activity
GSY65_RS18225	COG0789	Transcriptional regulator
GSY65_RS18230	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GSY65_RS18240	COG0561	phosphatase activity
GSY65_RS18245	COG0741	lytic transglycosylase activity
GSY65_RS18245	COG1196	nuclear chromosome segregation
GSY65_RS18245	COG0739	heme binding
GSY65_RS18250	COG4988	ABC transporter
GSY65_RS18255	COG1294	oxidase, subunit
GSY65_RS18260	COG1271	oxidase subunit
GSY65_RS18265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSY65_RS18270	COG1609	Transcriptional regulator
GSY65_RS18275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSY65_RS18285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GSY65_RS18310	COG0662	Cupin 2, conserved barrel domain protein
GSY65_RS18315	COG1950	PFAM Membrane protein of
GSY65_RS18320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSY65_RS18325	COG0626	cystathionine gamma-synthase activity
GSY65_RS18355	COG2814	Major facilitator Superfamily
GSY65_RS18375	COG0305	Participates in initiation and elongation during chromosome replication
GSY65_RS18390	COG0359	binds to the 23S rRNA
GSY65_RS18395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GSY65_RS18400	COG0629	single-stranded DNA binding
GSY65_RS18405	COG0360	Binds together with S18 to 16S ribosomal RNA
GSY65_RS18430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSY65_RS18440	COG1260	myo-inositol-1-phosphate synthase
GSY65_RS18450	COG0617	tRNA 3'-terminal CCA addition
GSY65_RS18465	COG0515	serine threonine protein kinase
GSY65_RS18465	COG2815	serine threonine protein kinase
GSY65_RS18470	COG1595	DNA-templated transcription, initiation
GSY65_RS18480	COG0492	ferredoxin-NADP+ reductase activity
GSY65_RS18485	COG3118	belongs to the thioredoxin family
GSY65_RS18500	COG1192	Involved in chromosome partitioning
GSY65_RS18505	COG0357	Ribosomal RNA small subunit methyltransferase G
GSY65_RS18515	COG0706	membrane insertase activity
GSY65_RS18520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GSY65_RS18525	COG0594	ribonuclease P activity
GSY65_RS18530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GSY65_RS18535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GSY65_RS18540	COG0592	DNA-directed DNA polymerase activity
GSY65_RS18545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GSY65_RS18550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GSY65_RS18555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GSY65_RS18560	COG0187	DNA topoisomerase II activity
GSY65_RS18565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GSY65_RS18595	COG0515	serine threonine protein kinase
GSY65_RS18620	COG0705	Rhomboid family
GSY65_RS18635	COG3764	Sortase (surface protein transpeptidase)
GSY65_RS18650	COG3764	Sortase (surface protein transpeptidase)
GSY65_RS18655	COG3764	Sortase (surface protein transpeptidase)
GSY65_RS18660	COG0515	serine threonine protein kinase
GSY65_RS18680	COG1716	ATPase activity
GSY65_RS18685	COG1716	ATPase activity
GSY65_RS18705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GSY65_RS18710	COG1733	regulation of RNA biosynthetic process
GSY65_RS18755	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY65_RS18765	COG1522	sequence-specific DNA binding
GSY65_RS18785	COG0746	molybdenum cofactor guanylyltransferase activity
GSY65_RS18790	COG0303	'Molybdopterin
GSY65_RS18795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSY65_RS18825	COG0515	serine threonine protein kinase
GSY65_RS18830	COG0515	serine threonine protein kinase
GSY65_RS18840	COG0022	dehydrogenase e1 component
GSY65_RS18845	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSY65_RS18865	COG2271	Major facilitator Superfamily
GSY65_RS18900	COG0531	amino acid
GSY65_RS18925	COG1362	aminopeptidase activity
GSY65_RS18930	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS18940	COG1741	Belongs to the pirin family
GSY65_RS18955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GSY65_RS19015	COG3866	Pectate lyase
GSY65_RS19030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSY65_RS19050	COG1289	transmembrane transporter activity
GSY65_RS19065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GSY65_RS19070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY65_RS19100	COG0745	RESPONSE REGULATOR receiver
GSY65_RS19155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY65_RS19175	COG4566	intracellular signal transduction
GSY65_RS19320	COG1733	regulation of RNA biosynthetic process
GSY65_RS19325	COG0137	argininosuccinate synthase activity
GSY65_RS19370	COG2764	glyoxalase bleomycin resistance protein dioxygenase
GSY65_RS19375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GSY65_RS19385	COG1609	Transcriptional regulator
GSY65_RS19425	COG3033	Beta-eliminating lyase
GSY65_RS19445	COG1131	(ABC) transporter
GSY65_RS19455	COG1595	DNA-templated transcription, initiation
GSY65_RS19465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSY65_RS19475	COG1595	DNA-templated transcription, initiation
GSY65_RS19490	COG0513	Belongs to the DEAD box helicase family
GSY65_RS19495	COG1278	Cold shock
GSY65_RS19515	COG0726	polysaccharide deacetylase
GSY65_RS19535	COG0745	RESPONSE REGULATOR receiver
GSY65_RS19540	COG2205	protein histidine kinase activity
GSY65_RS19560	COG2172	sigma factor antagonist activity
GSY65_RS19590	COG0640	Transcriptional regulator
GSY65_RS19625	COG1295	ribonuclease BN
GSY65_RS19625	COG1959	2 iron, 2 sulfur cluster binding
GSY65_RS19655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSY65_RS19660	COG1595	DNA-templated transcription, initiation
GSY65_RS19685	COG2268	Band 7 protein
GSY65_RS19795	COG2188	Transcriptional regulator
GSY65_RS19805	COG2188	Transcriptional regulator
GSY65_RS19870	COG0717	Belongs to the dCTP deaminase family
GSY65_RS19885	COG1595	DNA-templated transcription, initiation
GSY65_RS19940	COG2181	nitrate reductase activity
GSY65_RS19940	COG0247	lactate metabolic process
GSY65_RS19945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSY65_RS19950	COG0443	Heat shock 70 kDa protein
GSY65_RS19955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GSY65_RS19960	COG0484	heat shock protein binding
GSY65_RS19965	COG0789	Transcriptional regulator
GSY65_RS19985	COG2197	response regulator
GSY65_RS19995	COG1132	(ABC) transporter
GSY65_RS20030	COG0612	Peptidase, M16
GSY65_RS20050	COG1733	regulation of RNA biosynthetic process
GSY65_RS20065	COG4213	ABC transporter substrate-binding protein
GSY65_RS20100	COG0542	response to heat
GSY65_RS20150	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GSY65_RS20170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GSY65_RS20175	COG0191	fructose-bisphosphate aldolase activity
GSY65_RS20180	COG0477	Major facilitator Superfamily
GSY65_RS20190	COG3483	tryptophan 2,3-dioxygenase activity
GSY65_RS20215	COG4585	Histidine kinase
GSY65_RS20220	COG2197	response regulator
GSY65_RS20235	COG3559	Exporter of polyketide antibiotics
GSY65_RS20265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GSY65_RS20275	COG0463	Glycosyl transferase, family 2
GSY65_RS20280	COG1802	Transcriptional regulator
GSY65_RS20300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GSY65_RS20305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GSY65_RS20340	COG2205	protein histidine kinase activity
GSY65_RS20360	COG1595	DNA-templated transcription, initiation
GSY65_RS20405	COG0701	Predicted permease
GSY65_RS20435	COG4249	Peptidase C14 caspase catalytic subunit p20
GSY65_RS20435	COG2319	Wd-40 repeat
GSY65_RS20440	COG2197	response regulator
GSY65_RS20445	COG3851	Histidine kinase
GSY65_RS20465	COG0475	glutathione-regulated potassium exporter activity
GSY65_RS20500	COG1408	metallophosphoesterase
GSY65_RS20510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSY65_RS20525	COG0003	Pfam Anion-transporting ATPase
GSY65_RS20585	COG2267	carboxylic ester hydrolase activity
GSY65_RS20595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GSY65_RS20600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSY65_RS20605	COG0659	secondary active sulfate transmembrane transporter activity
GSY65_RS20665	COG1111	helicase
GSY65_RS20665	COG1205	dead DEAH box helicase
GSY65_RS20670	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY65_RS20675	COG2172	sigma factor antagonist activity
GSY65_RS20680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GSY65_RS20705	COG1754	DNA topoisomerase type I activity
GSY65_RS20705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSY65_RS20710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GSY65_RS20715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GSY65_RS20745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS20770	COG2197	response regulator
GSY65_RS20775	COG1132	(ABC) transporter
GSY65_RS20840	COG5002	protein histidine kinase activity
GSY65_RS20845	COG0745	RESPONSE REGULATOR receiver
GSY65_RS20860	COG1136	(ABC) transporter
GSY65_RS20865	COG1136	(ABC) transporter
GSY65_RS20865	COG0577	efflux transmembrane transporter activity
GSY65_RS20895	COG0596	Alpha beta hydrolase
GSY65_RS20900	COG3033	Beta-eliminating lyase
GSY65_RS20930	COG3629	intracellular signal transduction
GSY65_RS20930	COG3903	Transcriptional regulator
GSY65_RS20935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSY65_RS20935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSY65_RS20965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GSY65_RS20970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GSY65_RS20975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GSY65_RS20980	COG0254	rRNA binding
GSY65_RS20990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GSY65_RS21010	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS21015	COG2318	DinB family
GSY65_RS21035	COG0076	glutamate decarboxylase activity
GSY65_RS21040	COG0789	Transcriptional regulator
GSY65_RS21055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GSY65_RS21070	COG0037	tRNA processing
GSY65_RS21085	COG0302	gtp cyclohydrolase
GSY65_RS21100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GSY65_RS21105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GSY65_RS21140	COG0649	NAD binding
GSY65_RS21155	COG2197	response regulator
GSY65_RS21160	COG0640	Transcriptional regulator
GSY65_RS21175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GSY65_RS21180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GSY65_RS21190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GSY65_RS21205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GSY65_RS21220	COG0542	response to heat
GSY65_RS21225	COG0739	heme binding
GSY65_RS21240	COG2205	protein histidine kinase activity
GSY65_RS21245	COG0745	RESPONSE REGULATOR receiver
GSY65_RS21255	COG1595	DNA-templated transcription, initiation
GSY65_RS21275	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GSY65_RS21300	COG0248	Ppx GppA phosphatase
GSY65_RS21305	COG1082	Xylose isomerase domain protein TIM barrel
GSY65_RS21310	COG1309	transcriptional regulator
GSY65_RS21315	COG0129	dihydroxy-acid dehydratase activity
GSY65_RS21325	COG4991	sh3 domain protein
GSY65_RS21340	COG1129	ABC transporter
GSY65_RS21340	COG0842	Transport permease protein
GSY65_RS21350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSY65_RS21355	COG0180	Tryptophanyl-tRNA synthetase
GSY65_RS21385	COG0123	including yeast histone deacetylase and acetoin utilization protein
GSY65_RS21425	COG0560	Phosphoserine phosphatase
GSY65_RS21435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GSY65_RS21440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GSY65_RS21445	COG0181	hydroxymethylbilane synthase activity
GSY65_RS21450	COG1648	precorrin-2 dehydrogenase activity
GSY65_RS21450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSY65_RS21500	COG0531	amino acid
GSY65_RS21505	COG0113	porphobilinogen synthase activity
GSY65_RS21525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY65_RS21535	COG0018	arginyl-trna synthetase
GSY65_RS21540	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GSY65_RS21560	COG1690	Belongs to the RtcB family
GSY65_RS21575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS21590	COG2205	protein histidine kinase activity
GSY65_RS21615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GSY65_RS21655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSY65_RS21660	COG0406	alpha-ribazole phosphatase activity
GSY65_RS21670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY65_RS21680	COG1333	cytochrome c biogenesis protein
GSY65_RS21685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GSY65_RS21760	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GSY65_RS21780	COG0163	prenyltransferase activity
GSY65_RS21790	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GSY65_RS21805	COG1309	transcriptional regulator
GSY65_RS21845	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GSY65_RS21865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GSY65_RS21880	COG2226	methyltransferase
GSY65_RS21900	COG0791	NLP P60 protein
GSY65_RS21910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSY65_RS21915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSY65_RS21920	COG0649	NAD binding
GSY65_RS21930	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GSY65_RS21935	COG1034	ATP synthesis coupled electron transport
GSY65_RS21940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GSY65_RS21945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSY65_RS21950	COG0839	Belongs to the complex I subunit 6 family
GSY65_RS21955	COG0713	ATP synthesis coupled electron transport
GSY65_RS21960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSY65_RS21970	COG1007	ATP synthesis coupled electron transport
GSY65_RS21980	COG0514	ATP-dependent DNA helicase (RecQ)
GSY65_RS21985	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSY65_RS21995	COG0492	ferredoxin-NADP+ reductase activity
GSY65_RS22000	COG0561	phosphatase activity
GSY65_RS22105	COG0741	lytic transglycosylase activity
GSY65_RS22105	COG0739	heme binding
GSY65_RS22105	COG1196	nuclear chromosome segregation
GSY65_RS22135	COG0702	epimerase
GSY65_RS22140	COG1013	pyruvate-flavodoxin oxidoreductase activity
GSY65_RS22145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GSY65_RS22145	COG0674	pyruvate-flavodoxin oxidoreductase activity
GSY65_RS22165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSY65_RS22170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSY65_RS22175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSY65_RS22180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GSY65_RS22185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSY65_RS22190	COG0839	Belongs to the complex I subunit 6 family
GSY65_RS22195	COG0713	ATP synthesis coupled electron transport
GSY65_RS22210	COG1007	ATP synthesis coupled electron transport
GSY65_RS22215	COG0501	Belongs to the peptidase M48B family
GSY65_RS22220	COG3304	Inner membrane component domain
GSY65_RS22230	COG2261	transglycosylase associated protein
GSY65_RS22235	COG1666	GTP binding
GSY65_RS22255	COG0702	epimerase
GSY65_RS22265	COG0402	S-adenosylhomocysteine deaminase activity
GSY65_RS22280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GSY65_RS22285	COG2030	dehydratase
GSY65_RS22300	COG0477	Major facilitator Superfamily
GSY65_RS22305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GSY65_RS22310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSY65_RS22315	COG0436	Aminotransferase
GSY65_RS22330	COG0250	Participates in transcription elongation, termination and antitermination
GSY65_RS22335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GSY65_RS22340	COG0081	regulation of translation
GSY65_RS22350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GSY65_RS22360	COG0085	RNA polymerase activity
GSY65_RS22365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GSY65_RS22375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GSY65_RS22380	COG0049	tRNA binding
GSY65_RS22385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GSY65_RS22390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GSY65_RS22450	COG0051	transcription antitermination factor activity, RNA binding
GSY65_RS22455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GSY65_RS22460	COG0088	Forms part of the polypeptide exit tunnel
GSY65_RS22465	COG0089	rRNA binding
GSY65_RS22470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GSY65_RS22475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GSY65_RS22480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GSY65_RS22485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GSY65_RS22490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GSY65_RS22495	COG0255	Belongs to the universal ribosomal protein uL29 family
GSY65_RS22500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GSY65_RS22505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GSY65_RS22510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GSY65_RS22515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GSY65_RS22520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GSY65_RS22530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GSY65_RS22535	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GSY65_RS22540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GSY65_RS22545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GSY65_RS22550	COG1841	ribosomal large subunit assembly
GSY65_RS22555	COG0200	Binds to the 23S rRNA
GSY65_RS22565	COG0563	adenylate kinase activity
GSY65_RS22575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GSY65_RS22580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GSY65_RS22585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GSY65_RS22590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GSY65_RS22595	COG0202	RNA polymerase activity
GSY65_RS22600	COG0203	ribosomal protein L17
GSY65_RS22605	COG0101	tRNA pseudouridine synthase activity
GSY65_RS22615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GSY65_RS22620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GSY65_RS22625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSY65_RS22635	COG1072	(Pantothenic acid kinase))
GSY65_RS22650	COG0736	holo-[acyl-carrier-protein] synthase activity
GSY65_RS22655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSY65_RS22665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSY65_RS22675	COG0802	atpase or kinase
GSY65_RS22695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GSY65_RS22735	COG1175	transmembrane transport
GSY65_RS22740	COG1653	transport
GSY65_RS22755	COG1316	TRANSCRIPTIONal
GSY65_RS22765	COG4941	Belongs to the sigma-70 factor family
GSY65_RS22775	COG0726	polysaccharide deacetylase
GSY65_RS22785	COG0459	protein refolding
GSY65_RS22795	COG4221	oxidoreductase activity
GSY65_RS22805	COG0583	DNA-binding transcription factor activity
GSY65_RS22825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSY65_RS22835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GSY65_RS22860	COG2197	response regulator
GSY65_RS22865	COG1595	DNA-templated transcription, initiation
GSY65_RS22875	COG0516	GMP reductase activity
GSY65_RS22885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GSY65_RS22895	COG0515	serine threonine protein kinase
GSY65_RS22895	COG2815	serine threonine protein kinase
GSY65_RS22910	COG2815	serine threonine protein kinase
GSY65_RS22910	COG0515	serine threonine protein kinase
GSY65_RS22920	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS22930	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS22950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GSY65_RS22950	COG0519	Catalyzes the synthesis of GMP from XMP
GSY65_RS22990	COG2197	response regulator
GSY65_RS23030	COG0739	heme binding
GSY65_RS23055	COG0714	Associated with various cellular activities
GSY65_RS23060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GSY65_RS23070	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GSY65_RS23090	COG0045	succinate-CoA ligase (ADP-forming) activity
GSY65_RS23120	COG0138	bifunctional purine biosynthesis protein purh
GSY65_RS23135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSY65_RS23150	COG0039	L-malate dehydrogenase activity
GSY65_RS23175	COG0754	glutathionylspermidine amidase activity
GSY65_RS23180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSY65_RS23185	COG0180	Tryptophanyl-tRNA synthetase
GSY65_RS23220	COG1408	metallophosphoesterase
GSY65_RS23230	COG1309	transcriptional regulator
GSY65_RS23290	COG1053	succinate dehydrogenase
GSY65_RS23300	COG2009	succinate dehydrogenase
GSY65_RS23340	COG1595	DNA-templated transcription, initiation
GSY65_RS23350	COG1595	DNA-templated transcription, initiation
GSY65_RS23385	COG1216	Glycosyl transferase, family 2
GSY65_RS23400	COG2089	acid synthase
GSY65_RS23410	COG1473	amidohydrolase
GSY65_RS23410	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GSY65_RS23415	COG1744	ABC transporter substrate-binding protein PnrA-like
GSY65_RS23460	COG2814	Major facilitator Superfamily
GSY65_RS23465	COG0583	DNA-binding transcription factor activity
GSY65_RS23475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSY65_RS23500	COG2205	protein histidine kinase activity
GSY65_RS23505	COG0745	RESPONSE REGULATOR receiver
GSY65_RS23510	COG1595	DNA-templated transcription, initiation
GSY65_RS23535	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS23540	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS23560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSY65_RS23580	COG1349	DNA-binding transcription factor activity
GSY65_RS23585	COG1309	transcriptional regulator
GSY65_RS23590	COG4770	biotin carboxylase activity
GSY65_RS23600	COG0424	maF-like protein
GSY65_RS23615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSY65_RS23625	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GSY65_RS23630	COG1024	Enoyl-CoA hydratase
GSY65_RS23640	COG2986	histidine ammonia-lyase
GSY65_RS23655	COG1376	ErfK ybiS ycfS ynhG family protein
GSY65_RS23665	COG1136	(ABC) transporter
GSY65_RS23675	COG1064	alcohol dehydrogenase
GSY65_RS23680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSY65_RS23705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSY65_RS23725	COG1595	DNA-templated transcription, initiation
GSY65_RS23730	COG2255	four-way junction helicase activity
GSY65_RS23735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GSY65_RS23755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GSY65_RS23765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSY65_RS23795	COG1331	Highly conserved protein containing a thioredoxin domain
GSY65_RS23825	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GSY65_RS23835	COG1309	transcriptional regulator
GSY65_RS23945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GSY65_RS24005	COG2894	cell division
GSY65_RS24055	COG2885	chlorophyll binding
GSY65_RS24075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GSY65_RS24090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GSY65_RS24095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSY65_RS24105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSY65_RS24110	COG0450	alkyl hydroperoxide reductase
GSY65_RS24125	COG1136	(ABC) transporter
GSY65_RS24135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSY65_RS24150	COG0114	fumarate hydratase activity
GSY65_RS24155	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GSY65_RS24155	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GSY65_RS24180	COG0778	Nitroreductase
GSY65_RS24185	COG1722	exodeoxyribonuclease VII activity
GSY65_RS24190	COG1570	exodeoxyribonuclease VII activity
GSY65_RS24195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GSY65_RS24210	COG0012	GTP binding
GSY65_RS24215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSY65_RS24220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GSY65_RS24240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY65_RS24260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSY65_RS24280	COG2267	carboxylic ester hydrolase activity
GSY65_RS24290	COG0431	NADPH-dependent FMN reductase
GSY65_RS24305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GSY65_RS24330	COG2197	response regulator
GSY65_RS24415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GSY65_RS24420	COG1053	succinate dehydrogenase
GSY65_RS24450	COG4166	transmembrane transport
GSY65_RS24455	COG0601	transmembrane transport
GSY65_RS24460	COG0444	Belongs to the ABC transporter superfamily
GSY65_RS24465	COG4608	Belongs to the ABC transporter superfamily
GSY65_RS24475	COG0601	transmembrane transport
GSY65_RS24480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSY65_RS24485	COG0444	Belongs to the ABC transporter superfamily
GSY65_RS24490	COG4608	Belongs to the ABC transporter superfamily
GSY65_RS24505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSY65_RS24555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY65_RS24565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GSY65_RS24575	COG0519	Catalyzes the synthesis of GMP from XMP
GSY65_RS24580	COG1024	Enoyl-CoA hydratase
GSY65_RS24595	COG1595	DNA-templated transcription, initiation
GSY65_RS24605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSY65_RS24610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSY65_RS24645	COG0598	Magnesium transport protein CorA
GSY65_RS24665	COG2095	MarC family integral membrane protein
GSY65_RS24675	COG1432	Conserved Protein
GSY65_RS24780	COG0210	DNA helicase
GSY65_RS24785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY65_RS24825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GSY65_RS24875	COG3480	Lon protease (S16) C-terminal proteolytic domain
GSY65_RS24885	COG1615	UPF0182 protein
GSY65_RS24915	COG0483	inositol monophosphate 1-phosphatase activity
GSY65_RS24925	COG2076	Multidrug Resistance protein
GSY65_RS24935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GSY65_RS24945	COG2135	peptidase activity
GSY65_RS24955	COG1595	DNA-templated transcription, initiation
GSY65_RS24960	COG5662	AntiSigma factor
GSY65_RS24975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSY65_RS24975	COG2199	diguanylate cyclase activity
GSY65_RS24990	COG0242	peptide deformylase activity
GSY65_RS25020	COG1957	nucleoside hydrolase
GSY65_RS25035	COG2188	Transcriptional regulator
GSY65_RS25045	COG1175	transmembrane transport
GSY65_RS25055	COG1472	Belongs to the glycosyl hydrolase 3 family
GSY65_RS25060	COG0363	glucosamine-6-phosphate deaminase activity
GSY65_RS25080	COG1597	lipid kinase activity
GSY65_RS25110	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GSY65_RS25120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSY65_RS25155	COG0395	ABC-type sugar transport system, permease component
GSY65_RS25160	COG1175	transmembrane transport
GSY65_RS25170	COG1609	Transcriptional regulator
GSY65_RS25285	COG0582	viral genome integration into host DNA
GSY65_RS25310	COG1126	abc transporter atp-binding protein
GSY65_RS25325	COG0281	malic enzyme
GSY65_RS25330	COG0604	alcohol dehydrogenase
GSY65_RS25365	COG0567	Dehydrogenase, E1 component
GSY65_RS25365	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSY65_RS25370	COG2205	protein histidine kinase activity
GSY65_RS25375	COG0745	RESPONSE REGULATOR receiver
GSY65_RS25395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GSY65_RS25445	COG1309	transcriptional regulator
GSY65_RS25470	COG2205	protein histidine kinase activity
GSY65_RS25490	COG3285	dna ligase
GSY65_RS25490	COG1793	dna ligase
GSY65_RS25495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GSY65_RS25525	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GSY65_RS25530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY65_RS25655	COG0745	RESPONSE REGULATOR receiver
GSY65_RS25660	COG0018	arginyl-trna synthetase
GSY65_RS25665	COG0019	diaminopimelate decarboxylase activity
GSY65_RS25670	COG0460	homoserine dehydrogenase
GSY65_RS25675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GSY65_RS25680	COG0083	homoserine kinase activity
GSY65_RS25700	COG0254	rRNA binding
GSY65_RS25705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GSY65_RS25710	COG2890	protein-(glutamine-N5) methyltransferase activity
GSY65_RS25720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSY65_RS25725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSY65_RS25750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSY65_RS25755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GSY65_RS25760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSY65_RS25765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GSY65_RS25770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GSY65_RS25775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GSY65_RS25780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GSY65_RS25795	COG2197	response regulator
GSY65_RS25800	COG4585	Histidine kinase
GSY65_RS25825	COG1309	transcriptional regulator
GSY65_RS25830	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY65_RS25845	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GSY65_RS25895	COG0183	Belongs to the thiolase family
GSY65_RS25910	COG0745	RESPONSE REGULATOR receiver
GSY65_RS26010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GSY65_RS26015	COG0857	belongs to the CobB CobQ family
GSY65_RS26015	COG0280	phosphate acetyltransferase
GSY65_RS26020	COG0205	6-phosphofructokinase activity
GSY65_RS26035	COG4565	transcriptional regulatory protein
GSY65_RS26040	COG3290	protein histidine kinase activity
GSY65_RS26050	COG1301	dicarboxylic acid transport
GSY65_RS26075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GSY65_RS26080	COG3281	Trehalose synthase
GSY65_RS26090	COG0366	Alpha amylase catalytic
GSY65_RS26100	COG0058	SHG alpha-glucan phosphorylase activity
GSY65_RS26120	COG1132	(ABC) transporter
GSY65_RS26125	COG1132	(ABC) transporter
GSY65_RS26130	COG1132	(ABC) transporter
GSY65_RS26135	COG1132	(ABC) transporter
GSY65_RS26150	COG1376	ErfK ybiS ycfS ynhG family protein
GSY65_RS26155	COG1024	Enoyl-CoA hydratase
GSY65_RS26180	COG1760	l-serine dehydratase
GSY65_RS26185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSY65_RS26190	COG0509	glycine decarboxylation via glycine cleavage system
GSY65_RS26195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSY65_RS26220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSY65_RS26235	COG0444	Belongs to the ABC transporter superfamily
GSY65_RS26240	COG4608	Belongs to the ABC transporter superfamily
GSY65_RS26245	COG2860	membrane
GSY65_RS26275	COG3023	N-Acetylmuramoyl-L-alanine amidase
GSY65_RS26280	COG0482	sulfurtransferase activity
GSY65_RS26290	COG1611	Belongs to the LOG family
GSY65_RS26295	COG4221	oxidoreductase activity
GSY65_RS26305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GSY65_RS26315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSY65_RS26320	COG0154	amidase activity
GSY65_RS26330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSY65_RS26335	COG2409	Drug exporters of the RND superfamily
GSY65_RS26340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY65_RS26350	COG2197	response regulator
GSY65_RS26355	COG2133	pyrroloquinoline quinone binding
GSY65_RS26360	COG0667	Aldo Keto reductase
GSY65_RS26370	COG5001	Diguanylate cyclase
GSY65_RS26380	COG0440	acetolactate synthase activity
GSY65_RS26385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GSY65_RS26395	COG0477	Major facilitator Superfamily
GSY65_RS26420	COG0747	negative chemotaxis
GSY65_RS26425	COG2508	Transcriptional regulator
GSY65_RS26430	COG0506	proline dehydrogenase activity
GSY65_RS26435	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS26455	COG0473	3-isopropylmalate dehydrogenase activity
GSY65_RS26460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSY65_RS26465	COG0831	urea catabolic process
GSY65_RS26465	COG0832	Belongs to the urease beta subunit family
GSY65_RS26470	COG0804	urea catabolic process
GSY65_RS26475	COG2957	Belongs to the agmatine deiminase family
GSY65_RS26495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSY65_RS26520	COG5492	domain, Protein
GSY65_RS26525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSY65_RS26545	COG2018	Roadblock/LC7 domain
GSY65_RS26565	COG2018	Roadblock/LC7 domain
GSY65_RS26570	COG5002	protein histidine kinase activity
GSY65_RS26580	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSY65_RS26585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSY65_RS26630	COG1414	Transcriptional regulator
GSY65_RS26635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GSY65_RS26640	COG0066	3-isopropylmalate dehydratase activity
GSY65_RS26650	COG0776	regulation of translation
GSY65_RS26670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GSY65_RS26675	COG1181	Belongs to the D-alanine--D-alanine ligase family
GSY65_RS26695	COG0351	phosphomethylpyrimidine kinase
GSY65_RS26700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GSY65_RS26705	COG1461	Dihydroxyacetone kinase
GSY65_RS26725	COG0742	ribosomal rna small subunit methyltransferase
GSY65_RS26730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GSY65_RS26745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GSY65_RS26750	COG0571	ribonuclease III activity
GSY65_RS26755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GSY65_RS26760	COG1733	regulation of RNA biosynthetic process
GSY65_RS26780	COG2340	Cysteine-rich secretory protein family
GSY65_RS26785	COG1254	Belongs to the acylphosphatase family
GSY65_RS26795	COG1196	nuclear chromosome segregation
GSY65_RS26800	COG0477	Major facilitator Superfamily
GSY65_RS26835	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GSY65_RS26850	COG0442	prolyl-tRNA aminoacylation
GSY65_RS26860	COG0228	four-way junction DNA binding
GSY65_RS26865	COG1837	Belongs to the UPF0109 family
GSY65_RS26870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GSY65_RS26875	COG0336	Belongs to the RNA methyltransferase TrmD family
GSY65_RS26880	COG0335	large ribosomal subunit rRNA binding
GSY65_RS26895	COG0681	Belongs to the peptidase S26 family
GSY65_RS26900	COG0681	Belongs to the peptidase S26 family
GSY65_RS26905	COG1051	belongs to the nudix hydrolase family
GSY65_RS26915	COG0792	nuclease activity
GSY65_RS26920	COG0606	chelatase, subunit chli
GSY65_RS26930	COG1191	sigma factor activity
GSY65_RS26945	COG0052	Belongs to the universal ribosomal protein uS2 family
GSY65_RS26950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GSY65_RS26955	COG0528	UMP kinase activity
GSY65_RS26960	COG0233	cytoplasmic translational termination
GSY65_RS26965	COG0575	Belongs to the CDS family
GSY65_RS26970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GSY65_RS26980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GSY65_RS26985	COG3842	ATPase activity
GSY65_RS27015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GSY65_RS27025	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS27050	COG2353	YceI-like domain
GSY65_RS27065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSY65_RS27090	COG3842	ATPase activity
GSY65_RS27095	COG1176	ABC-type spermidine putrescine transport system, permease component I
GSY65_RS27100	COG1177	transmembrane transport
GSY65_RS27105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY65_RS27130	COG2508	Transcriptional regulator
GSY65_RS27135	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS27150	COG4209	transmembrane transport
GSY65_RS27155	COG0395	ABC-type sugar transport system, permease component
GSY65_RS27185	COG1609	Transcriptional regulator
GSY65_RS27195	COG3250	beta-galactosidase activity
GSY65_RS27205	COG0628	permease
GSY65_RS27230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GSY65_RS27235	COG0750	zinc metalloprotease
GSY65_RS27240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GSY65_RS27255	COG0442	prolyl-tRNA aminoacylation
GSY65_RS27275	COG0779	Required for maturation of 30S ribosomal subunits
GSY65_RS27290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GSY65_RS27300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GSY65_RS27305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GSY65_RS27320	COG0455	bacterial-type flagellum organization
GSY65_RS27340	COG1404	Belongs to the peptidase S8 family
GSY65_RS27360	COG1674	ftsk spoiiie
GSY65_RS27370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GSY65_RS27375	COG1185	polyribonucleotide nucleotidyltransferase activity
GSY65_RS27380	COG0612	Peptidase, M16
GSY65_RS27385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GSY65_RS27405	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GSY65_RS27410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY65_RS27415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GSY65_RS27445	COG2770	Histidine kinase
GSY65_RS27445	COG2208	phosphoserine phosphatase activity
GSY65_RS27450	COG3850	Histidine kinase
GSY65_RS27450	COG3437	response regulator, receiver
GSY65_RS27450	COG2205	protein histidine kinase activity
GSY65_RS27450	COG4999	Histidine kinase
GSY65_RS27460	COG1674	ftsk spoiiie
GSY65_RS27470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSY65_RS27480	COG1058	Belongs to the CinA family
GSY65_RS27480	COG1546	Belongs to the CinA family
GSY65_RS27485	COG1396	sequence-specific DNA binding
GSY65_RS27490	COG0783	Belongs to the Dps family
GSY65_RS27495	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS27500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GSY65_RS27505	COG1201	RNA secondary structure unwinding
GSY65_RS27535	COG0628	permease
GSY65_RS27540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GSY65_RS27555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSY65_RS27560	COG0765	amino acid transport
GSY65_RS27565	COG0765	amino acid transport
GSY65_RS27570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY65_RS27575	COG1126	abc transporter atp-binding protein
GSY65_RS27580	COG0745	RESPONSE REGULATOR receiver
GSY65_RS27585	COG2205	protein histidine kinase activity
GSY65_RS27610	COG1414	Transcriptional regulator
GSY65_RS27635	COG2267	carboxylic ester hydrolase activity
GSY65_RS27640	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS27655	COG0604	alcohol dehydrogenase
GSY65_RS27655	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS27655	COG3321	synthase
GSY65_RS27660	COG3384	dioxygenase
GSY65_RS27665	COG3971	2-oxopent-4-enoate hydratase activity
GSY65_RS27680	COG0477	Major facilitator Superfamily
GSY65_RS27685	COG2124	cytochrome p450
GSY65_RS27695	COG2986	histidine ammonia-lyase
GSY65_RS27710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSY65_RS27730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GSY65_RS27740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GSY65_RS27745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSY65_RS27755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GSY65_RS27785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSY65_RS27790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GSY65_RS27795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSY65_RS27810	COG0588	phosphoglycerate mutase activity
GSY65_RS27830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSY65_RS27875	COG2186	Transcriptional regulator
GSY65_RS27880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSY65_RS27895	COG0187	DNA topoisomerase II activity
GSY65_RS27905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY65_RS27910	COG4565	transcriptional regulatory protein
GSY65_RS27915	COG3290	protein histidine kinase activity
GSY65_RS27925	COG0523	cobalamin synthesis protein
GSY65_RS27930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GSY65_RS27935	COG0612	Peptidase, M16
GSY65_RS27950	COG1802	Transcriptional regulator
GSY65_RS27955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY65_RS27965	COG0045	succinate-CoA ligase (ADP-forming) activity
GSY65_RS27965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY65_RS27965	COG1042	CoA-binding domain protein
GSY65_RS27980	COG1435	thymidine kinase activity
GSY65_RS28020	COG0745	RESPONSE REGULATOR receiver
GSY65_RS28025	COG2205	protein histidine kinase activity
GSY65_RS28050	COG0756	dUTP diphosphatase activity
GSY65_RS28075	COG0569	domain protein
GSY65_RS28080	COG0531	amino acid
GSY65_RS28085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSY65_RS28120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY65_RS28175	COG1278	Cold shock
GSY65_RS28180	COG0513	Belongs to the DEAD box helicase family
GSY65_RS28280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSY65_RS28285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GSY65_RS28285	COG1116	anion transmembrane transporter activity
GSY65_RS28290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GSY65_RS28330	COG0745	RESPONSE REGULATOR receiver
GSY65_RS28335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS28345	COG0431	NADPH-dependent FMN reductase
GSY65_RS28355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS28370	COG1609	Transcriptional regulator
GSY65_RS28420	COG0243	molybdopterin cofactor binding
GSY65_RS28425	COG1799	cell septum assembly
GSY65_RS28430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSY65_RS28450	COG2226	methyltransferase
GSY65_RS28460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSY65_RS28465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSY65_RS28485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSY65_RS28590	COG0494	nUDIX hydrolase
GSY65_RS28595	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS28600	COG1260	myo-inositol-1-phosphate synthase
GSY65_RS28650	COG1131	(ABC) transporter
GSY65_RS28665	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS28680	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GSY65_RS28690	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS28695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GSY65_RS28700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSY65_RS28715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GSY65_RS28740	COG1175	transmembrane transport
GSY65_RS28745	COG0395	ABC-type sugar transport system, permease component
GSY65_RS28750	COG1940	carbohydrate kinase activity
GSY65_RS28755	COG4213	ABC transporter substrate-binding protein
GSY65_RS28765	COG4214	carbohydrate transport
GSY65_RS28770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GSY65_RS28775	COG0531	amino acid
GSY65_RS28785	COG1024	Enoyl-CoA hydratase
GSY65_RS28785	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY65_RS28790	COG0183	Belongs to the thiolase family
GSY65_RS28795	COG1609	Transcriptional regulator
GSY65_RS28810	COG1175	transmembrane transport
GSY65_RS28815	COG0395	ABC-type sugar transport system, permease component
GSY65_RS28820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GSY65_RS28835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GSY65_RS28850	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSY65_RS28880	COG3220	belongs to the UPF0276 family
GSY65_RS28915	COG0330	HflC and HflK could
GSY65_RS28950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSY65_RS28955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSY65_RS28970	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GSY65_RS28975	COG1335	isochorismatase
GSY65_RS28980	COG2259	Doxx family
GSY65_RS28985	COG3619	membrane
GSY65_RS28995	COG3903	Transcriptional regulator
GSY65_RS28995	COG3629	intracellular signal transduction
GSY65_RS29000	COG3903	Transcriptional regulator
GSY65_RS29000	COG3629	intracellular signal transduction
GSY65_RS29055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY65_RS29070	COG2018	Roadblock/LC7 domain
GSY65_RS29080	COG0644	oxidoreductase
GSY65_RS29095	COG2203	Gaf domain
GSY65_RS29095	COG2199	diguanylate cyclase activity
GSY65_RS29130	COG2124	cytochrome p450
GSY65_RS29170	COG1404	Belongs to the peptidase S8 family
GSY65_RS29190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSY65_RS29195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GSY65_RS29205	COG3173	Aminoglycoside phosphotransferase
GSY65_RS29310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSY65_RS29315	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GSY65_RS29345	COG0175	sulfate reduction
GSY65_RS29375	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS29470	COG3046	protein related to deoxyribodipyrimidine photolyase
GSY65_RS29490	COG1309	transcriptional regulator
GSY65_RS29495	COG2040	homocysteine
GSY65_RS29500	COG0531	amino acid
GSY65_RS29525	COG2755	lipolytic protein G-D-S-L family
GSY65_RS29550	COG0395	ABC-type sugar transport system, permease component
GSY65_RS29555	COG1175	transmembrane transport
GSY65_RS29565	COG1940	carbohydrate kinase activity
GSY65_RS29570	COG0277	FAD linked oxidase domain protein
GSY65_RS29590	COG1162	GTPase activity
GSY65_RS29630	COG1802	Transcriptional regulator
GSY65_RS29645	COG3835	regulator
GSY65_RS29660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GSY65_RS29665	COG2252	PERMEase
GSY65_RS29690	COG0673	inositol 2-dehydrogenase activity
GSY65_RS29700	COG1175	transmembrane transport
GSY65_RS29705	COG0395	ABC-type sugar transport system, permease component
GSY65_RS29725	COG0673	inositol 2-dehydrogenase activity
GSY65_RS29735	COG2188	Transcriptional regulator
GSY65_RS29740	COG3962	Belongs to the TPP enzyme family
GSY65_RS29750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY65_RS29775	COG0641	radical SAM
GSY65_RS29805	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GSY65_RS29825	COG0583	DNA-binding transcription factor activity
GSY65_RS29830	COG0183	Belongs to the thiolase family
GSY65_RS29840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GSY65_RS29855	COG1132	(ABC) transporter
GSY65_RS29870	COG1113	amino acid transport
GSY65_RS29895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GSY65_RS29930	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GSY65_RS29935	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GSY65_RS29940	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GSY65_RS29950	COG2205	protein histidine kinase activity
GSY65_RS29955	COG0745	RESPONSE REGULATOR receiver
GSY65_RS29975	COG0598	Magnesium transport protein CorA
GSY65_RS29995	COG2197	response regulator
GSY65_RS30000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSY65_RS30005	COG0318	PFAM AMP-dependent synthetase and ligase
GSY65_RS30015	COG3960	tartronate-semialdehyde synthase activity
GSY65_RS30020	COG2084	Dehydrogenase
GSY65_RS30025	COG3622	Belongs to the hyi family
GSY65_RS30045	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GSY65_RS30065	COG0375	protein maturation
GSY65_RS30085	COG0298	carbon dioxide binding
GSY65_RS30090	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GSY65_RS30105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSY65_RS30105	COG1024	Enoyl-CoA hydratase
GSY65_RS30125	COG2351	hydroxyisourate hydrolase activity
GSY65_RS30155	COG0406	alpha-ribazole phosphatase activity
GSY65_RS30160	COG0436	Aminotransferase
GSY65_RS30165	COG1733	regulation of RNA biosynthetic process
GSY65_RS30180	COG4264	IucA IucC family
GSY65_RS30205	COG0367	asparagine synthase
GSY65_RS30210	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GSY65_RS30210	COG2308	Evidence 4 Homologs of previously reported genes of
GSY65_RS30230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY65_RS30235	COG1120	ATPase activity
GSY65_RS30260	COG1132	(ABC) transporter
GSY65_RS30265	COG1132	(ABC) transporter
GSY65_RS30285	COG0583	DNA-binding transcription factor activity
GSY65_RS30325	COG1414	Transcriptional regulator
GSY65_RS30330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GSY65_RS30335	COG4266	Belongs to the allantoicase family
GSY65_RS30355	COG0667	Aldo Keto reductase
GSY65_RS30360	COG2197	response regulator
GSY65_RS30385	COG1940	carbohydrate kinase activity
GSY65_RS30395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSY65_RS30415	COG1191	sigma factor activity
GSY65_RS30430	COG0739	heme binding
GSY65_RS30430	COG0741	lytic transglycosylase activity
GSY65_RS30430	COG1196	nuclear chromosome segregation
GSY65_RS30475	COG0464	growth
GSY65_RS30540	COG3647	Membrane
GSY65_RS30565	COG0009	L-threonylcarbamoyladenylate synthase
GSY65_RS30625	COG0395	ABC-type sugar transport system, permease component
GSY65_RS30700	COG0745	RESPONSE REGULATOR receiver
GSY65_RS30705	COG2205	protein histidine kinase activity
GSY65_RS30760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GSY65_RS30795	COG1051	belongs to the nudix hydrolase family
GSY65_RS30830	COG0302	gtp cyclohydrolase
GSY65_RS30835	COG0602	queuosine metabolic process
GSY65_RS30895	COG3387	PFAM Glycoside hydrolase 15-related
GSY65_RS30945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSY65_RS30950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSY65_RS30985	COG0405	Gamma-glutamyltransferase
GSY65_RS31005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSY65_RS31010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GSY65_RS31025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GSY65_RS31035	COG1953	Uracil, thiamine, allantoin
GSY65_RS31055	COG0483	inositol monophosphate 1-phosphatase activity
GSY65_RS31065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GSY65_RS31070	COG1082	Xylose isomerase domain protein TIM barrel
GSY65_RS31100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GSY65_RS31110	COG0640	Transcriptional regulator
GSY65_RS31125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSY65_RS31150	COG1929	Belongs to the glycerate kinase type-1 family
GSY65_RS31165	COG0688	phosphatidylethanolamine metabolic process
GSY65_RS31170	COG1960	acyl-CoA dehydrogenase activity
GSY65_RS31200	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY65_RS31215	COG0596	Alpha beta hydrolase
GSY65_RS31245	COG2362	D-Aminopeptidase
GSY65_RS31250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY65_RS31255	COG0823	Involved in the tonB-independent uptake of proteins
GSY65_RS31255	COG4946	Tricorn protease homolog
GSY65_RS31255	COG1506	peptidase
GSY65_RS31260	COG1619	proteins homologs of microcin C7 resistance protein MccF
GSY65_RS31285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY65_RS31355	COG2226	methyltransferase
GSY65_RS31360	COG0671	phosphoesterase, PA-phosphatase related
GSY65_RS31365	COG0488	(ABC) transporter
GSY65_RS31385	COG0693	protein deglycase activity
GSY65_RS31435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSY65_RS31460	COG0443	Heat shock 70 kDa protein
GSY65_RS31480	COG2154	pterin-4-alpha-carbinolamine dehydratase
GSY65_RS31495	COG3401	FG-GAP repeat protein
GSY65_RS31505	COG4733	cellulase activity
GSY65_RS31505	COG5297	Belongs to the glycosyl hydrolase family 6
GSY65_RS31510	COG5297	Belongs to the glycosyl hydrolase family 6
GSY65_RS31525	COG0656	L-ascorbic acid biosynthetic process
GSY65_RS31535	COG0583	DNA-binding transcription factor activity
GSY65_RS31550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GSY65_RS31565	COG3383	formate dehydrogenase (NAD+) activity
GSY65_RS31570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GSY65_RS31580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSY65_RS31590	COG1940	carbohydrate kinase activity
GSY65_RS31595	COG1129	ABC transporter
GSY65_RS31600	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSY65_RS31605	COG1879	ABC-type sugar transport system periplasmic component
GSY65_RS31610	COG0673	inositol 2-dehydrogenase activity
GSY65_RS31620	COG3507	Belongs to the glycosyl hydrolase 43 family
GSY65_RS31665	COG2223	nitrite transmembrane transporter activity
GSY65_RS31675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GSY65_RS31685	COG0045	succinate-CoA ligase (ADP-forming) activity
GSY65_RS31695	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS31730	COG4124	Belongs to the glycosyl hydrolase 26 family
GSY65_RS31750	COG4249	Peptidase C14 caspase catalytic subunit p20
GSY65_RS31750	COG2319	Wd-40 repeat
GSY65_RS31780	COG0673	inositol 2-dehydrogenase activity
GSY65_RS31785	COG1028	Short-chain dehydrogenase reductase Sdr
GSY65_RS31795	COG1609	Transcriptional regulator
GSY65_RS31825	COG0438	transferase activity, transferring glycosyl groups
GSY65_RS31845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSY65_RS31885	COG3467	pyridoxamine 5'-phosphate
GSY65_RS31895	COG0477	Major facilitator Superfamily
GSY65_RS31905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSY65_RS31915	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GSY65_RS31920	COG0166	Belongs to the GPI family
GSY65_RS31935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSY65_RS31940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GSY65_RS31995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GSY65_RS32025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY65_RS32030	COG1349	DNA-binding transcription factor activity
GSY65_RS32035	COG1486	melibiose metabolic process
GSY65_RS32135	COG3511	phospholipase C
GSY65_RS32160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GSY65_RS32165	COG0477	Major facilitator Superfamily
GSY65_RS32175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSY65_RS32185	COG3485	protocatechuate 3,4-dioxygenase
GSY65_RS32190	COG3485	protocatechuate 3,4-dioxygenase
GSY65_RS32200	COG1470	cell adhesion involved in biofilm formation
GSY65_RS32210	COG1793	dna ligase
GSY65_RS32220	COG1309	transcriptional regulator
GSY65_RS32275	COG1834	amidinotransferase
GSY65_RS32280	COG0488	(ABC) transporter
GSY65_RS32300	COG1515	deoxyribonuclease V activity
GSY65_RS32305	COG3268	Saccharopine dehydrogenase
GSY65_RS32315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GSY65_RS32320	COG0183	Belongs to the thiolase family
GSY65_RS32325	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY65_RS32325	COG1024	Enoyl-CoA hydratase
GSY65_RS32340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GSY65_RS32345	COG2936	dipeptidyl-peptidase activity
GSY65_RS32355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GSY65_RS32370	COG0488	(ABC) transporter
GSY65_RS32375	COG2183	response to ionizing radiation
GSY65_RS32390	COG1024	Enoyl-CoA hydratase
GSY65_RS32405	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GSY65_RS32430	COG0371	Dehydrogenase
GSY65_RS32450	COG1134	teichoic acid transport
GSY65_RS32450	COG1388	LysM domain
GSY65_RS32455	COG1562	ergosterol biosynthetic process
GSY65_RS32465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GSY65_RS32475	COG1657	PFAM Prenyltransferase squalene oxidase
GSY65_RS32490	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GSY65_RS32530	COG2755	lipolytic protein G-D-S-L family
GSY65_RS32540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GSY65_RS32550	COG0577	efflux transmembrane transporter activity
GSY65_RS32555	COG0577	efflux transmembrane transporter activity
GSY65_RS32555	COG1136	(ABC) transporter
GSY65_RS32570	COG2301	Belongs to the HpcH HpaI aldolase family
GSY65_RS32580	COG0439	Biotin carboxylase
GSY65_RS32585	COG0511	ligase activity, forming carbon-carbon bonds
GSY65_RS32590	COG1984	allophanate hydrolase subunit 2
GSY65_RS32600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GSY65_RS32630	COG1012	belongs to the aldehyde dehydrogenase family
GSY65_RS32645	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GSY65_RS32650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GSY65_RS32680	COG4221	oxidoreductase activity
GSY65_RS32715	COG1063	alcohol dehydrogenase
GSY65_RS32720	COG0156	8-amino-7-oxononanoate synthase activity
GSY65_RS32725	COG0583	DNA-binding transcription factor activity
GSY65_RS32735	COG0456	acetyltransferase
GSY65_RS32735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GSY65_RS32745	COG3958	Transketolase
GSY65_RS32750	COG3959	Transketolase, thiamine diphosphate binding domain
GSY65_RS32765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSY65_RS32770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GSY65_RS32795	COG3938	Belongs to the proline racemase family
GSY65_RS32800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY65_RS32815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY65_RS32815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY65_RS32820	COG3387	PFAM Glycoside hydrolase 15-related
GSY65_RS32825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GSY65_RS32835	COG0783	Belongs to the Dps family
GSY65_RS32845	COG2267	carboxylic ester hydrolase activity
GSY65_RS32870	COG1132	(ABC) transporter
GSY65_RS32890	COG1454	alcohol dehydrogenase
GSY65_RS32895	COG2353	YceI-like domain
GSY65_RS32910	COG0641	radical SAM
GSY65_RS32920	COG1192	Involved in chromosome partitioning
GSY65_RS32955	COG1846	Transcriptional regulator
GSY65_RS32965	COG2838	Isocitrate dehydrogenase
GSY65_RS32970	COG0668	transmembrane transport
GSY65_RS32980	COG1132	(ABC) transporter
GSY65_RS33010	COG3693	PFAM glycoside hydrolase, family 10
GSY65_RS33015	COG0513	Belongs to the DEAD box helicase family
GSY65_RS33035	COG0577	efflux transmembrane transporter activity
GSY65_RS33040	COG1136	(ABC) transporter
GSY65_RS33040	COG0577	efflux transmembrane transporter activity
GSY65_RS33055	COG2205	protein histidine kinase activity
GSY65_RS33060	COG0745	RESPONSE REGULATOR receiver
GSY65_RS33065	COG3629	intracellular signal transduction
GSY65_RS33065	COG3903	Transcriptional regulator
GSY65_RS33075	COG3629	intracellular signal transduction
GSY65_RS33075	COG3903	Transcriptional regulator
GSY65_RS33085	COG1674	ftsk spoiiie
GSY65_RS33155	COG2124	cytochrome p450