locus-tag	class	description
DDW44_RS00085	COG2826	transposase and inactivated derivatives, IS30 family
DDW44_RS00100	COG3328	transposase activity
DDW44_RS00120	COG1653	transport
DDW44_RS00160	COG2226	methyltransferase
DDW44_RS00180	COG3548	integral membrane protein
DDW44_RS00190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDW44_RS00195	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS00210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDW44_RS00220	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS00230	COG3842	ATPase activity
DDW44_RS00235	COG1177	transmembrane transport
DDW44_RS00250	COG4638	Rieske (2fe-2S)
DDW44_RS00260	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DDW44_RS00270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDW44_RS00270	COG1042	CoA-binding domain protein
DDW44_RS00270	COG0045	succinate-CoA ligase (ADP-forming) activity
DDW44_RS00280	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS00285	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS00295	COG1309	transcriptional regulator
DDW44_RS00305	COG4585	Histidine kinase
DDW44_RS00325	COG3220	belongs to the UPF0276 family
DDW44_RS00335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDW44_RS00375	COG0702	epimerase
DDW44_RS00395	COG4977	sequence-specific DNA binding
DDW44_RS00400	COG0506	proline dehydrogenase activity
DDW44_RS00405	COG1280	lysine exporter protein (LysE YggA)
DDW44_RS00430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDW44_RS00440	COG2197	response regulator
DDW44_RS00465	COG0604	alcohol dehydrogenase
DDW44_RS00470	COG2409	Drug exporters of the RND superfamily
DDW44_RS00475	COG4585	Histidine kinase
DDW44_RS00480	COG2197	response regulator
DDW44_RS00505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DDW44_RS00510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DDW44_RS00550	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DDW44_RS00555	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DDW44_RS00560	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DDW44_RS00590	COG1051	belongs to the nudix hydrolase family
DDW44_RS00625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDW44_RS00625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DDW44_RS00630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DDW44_RS00635	COG0730	response to heat
DDW44_RS00640	COG1937	Protein conserved in bacteria
DDW44_RS00650	COG0589	response to stress
DDW44_RS00655	COG2239	Acts as a magnesium transporter
DDW44_RS00670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDW44_RS00670	COG0574	Belongs to the PEP-utilizing enzyme family
DDW44_RS00700	COG0516	GMP reductase activity
DDW44_RS00700	COG0517	IMP dehydrogenase activity
DDW44_RS00735	COG0071	Belongs to the small heat shock protein (HSP20) family
DDW44_RS00775	COG1349	DNA-binding transcription factor activity
DDW44_RS00780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDW44_RS00800	COG0642	Histidine kinase
DDW44_RS00800	COG3850	Histidine kinase
DDW44_RS00845	COG0516	GMP reductase activity
DDW44_RS00845	COG0517	IMP dehydrogenase activity
DDW44_RS00850	COG3387	PFAM Glycoside hydrolase 15-related
DDW44_RS00895	COG0330	HflC and HflK could
DDW44_RS00955	COG0298	carbon dioxide binding
DDW44_RS00960	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DDW44_RS00965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DDW44_RS00970	COG0375	protein maturation
DDW44_RS01000	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DDW44_RS01010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDW44_RS01010	COG1024	Enoyl-CoA hydratase
DDW44_RS01035	COG3290	protein histidine kinase activity
DDW44_RS01045	COG1136	(ABC) transporter
DDW44_RS01055	COG1653	transport
DDW44_RS01060	COG0366	Alpha amylase catalytic
DDW44_RS01065	COG1653	transport
DDW44_RS01070	COG1175	transmembrane transport
DDW44_RS01075	COG0395	ABC-type sugar transport system, permease component
DDW44_RS01080	COG0463	Glycosyl transferase, family 2
DDW44_RS01095	COG0765	amino acid transport
DDW44_RS01100	COG0765	amino acid transport
DDW44_RS01105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDW44_RS01110	COG1126	abc transporter atp-binding protein
DDW44_RS01125	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS01135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDW44_RS01140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DDW44_RS01160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DDW44_RS01160	COG1796	DNA polymerase
DDW44_RS01185	COG1982	Orn Lys Arg decarboxylase major
DDW44_RS01190	COG2208	phosphoserine phosphatase activity
DDW44_RS01190	COG2172	sigma factor antagonist activity
DDW44_RS01190	COG1366	Belongs to the anti-sigma-factor antagonist family
DDW44_RS01215	COG0395	ABC-type sugar transport system, permease component
DDW44_RS01220	COG1175	transmembrane transport
DDW44_RS01225	COG1653	transport
DDW44_RS01265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDW44_RS01275	COG2867	negative regulation of translational initiation
DDW44_RS01310	COG4264	IucA IucC family
DDW44_RS01315	COG0019	diaminopimelate decarboxylase activity
DDW44_RS01340	COG0714	Associated with various cellular activities
DDW44_RS01345	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DDW44_RS01365	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS01385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DDW44_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
DDW44_RS01455	COG0671	phosphoesterase, PA-phosphatase related
DDW44_RS01465	COG1309	transcriptional regulator
DDW44_RS01485	COG0640	Transcriptional regulator
DDW44_RS01490	COG1764	response to oxidative stress
DDW44_RS01495	COG1846	Transcriptional regulator
DDW44_RS01500	COG1902	pentaerythritol trinitrate reductase activity
DDW44_RS01510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DDW44_RS01515	COG2971	BadF BadG BcrA BcrD
DDW44_RS01525	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DDW44_RS01545	COG1522	sequence-specific DNA binding
DDW44_RS01550	COG0006	proline dipeptidase activity
DDW44_RS01575	COG0156	8-amino-7-oxononanoate synthase activity
DDW44_RS01585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDW44_RS01590	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DDW44_RS01625	COG0432	Pfam Uncharacterised protein family UPF0047
DDW44_RS01635	COG1132	(ABC) transporter
DDW44_RS01645	COG3548	integral membrane protein
DDW44_RS01665	COG0386	Belongs to the glutathione peroxidase family
DDW44_RS01670	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS01680	COG0242	peptide deformylase activity
DDW44_RS01690	COG3442	glutamine amidotransferase
DDW44_RS01695	COG0205	6-phosphofructokinase activity
DDW44_RS01705	COG0204	Acyl-transferase
DDW44_RS01710	COG0829	nickel cation binding
DDW44_RS01715	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DDW44_RS01720	COG0830	nickel cation binding
DDW44_RS01775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DDW44_RS01840	COG1648	precorrin-2 dehydrogenase activity
DDW44_RS01840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DDW44_RS01845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DDW44_RS01860	COG1464	Belongs to the NlpA lipoprotein family
DDW44_RS01865	COG2011	ABC-type metal ion transport system permease component
DDW44_RS01870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DDW44_RS01900	COG0584	glycerophosphoryl diester phosphodiesterase
DDW44_RS01905	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS01905	COG0204	Acyl-transferase
DDW44_RS01910	COG0477	Major facilitator Superfamily
DDW44_RS01930	COG0165	Argininosuccinate lyase
DDW44_RS01935	COG0137	argininosuccinate synthase activity
DDW44_RS01965	COG1438	arginine binding
DDW44_RS01970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDW44_RS01975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DDW44_RS01980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DDW44_RS01985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DDW44_RS02000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDW44_RS02005	COG0697	spore germination
DDW44_RS02015	COG1649	PFAM Uncharacterised BCR, COG1649
DDW44_RS02040	COG0072	phenylalanine-tRNA ligase activity
DDW44_RS02040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDW44_RS02045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DDW44_RS02050	COG5002	protein histidine kinase activity
DDW44_RS02055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDW44_RS02060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DDW44_RS02065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DDW44_RS02070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DDW44_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS02110	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS02115	COG0174	glutamine synthetase
DDW44_RS02120	COG2186	Transcriptional regulator
DDW44_RS02125	COG0531	amino acid
DDW44_RS02130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DDW44_RS02145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DDW44_RS02160	COG0517	IMP dehydrogenase activity
DDW44_RS02160	COG4175	Glycine betaine
DDW44_RS02165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DDW44_RS02175	COG1595	DNA-templated transcription, initiation
DDW44_RS02190	COG0805	protein transport
DDW44_RS02195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DDW44_RS02230	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DDW44_RS02240	COG1609	Transcriptional regulator
DDW44_RS02245	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DDW44_RS02250	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DDW44_RS02260	COG4122	O-methyltransferase activity
DDW44_RS02265	COG1222	aaa ATPase
DDW44_RS02285	COG0517	IMP dehydrogenase activity
DDW44_RS02285	COG1994	Peptidase M50
DDW44_RS02295	COG2197	response regulator
DDW44_RS02300	COG4166	transmembrane transport
DDW44_RS02305	COG4166	transmembrane transport
DDW44_RS02315	COG1410	methionine synthase
DDW44_RS02315	COG0646	methionine synthase
DDW44_RS02320	COG1414	Transcriptional regulator
DDW44_RS02325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DDW44_RS02330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDW44_RS02335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DDW44_RS02340	COG2186	Transcriptional regulator
DDW44_RS02350	COG0215	cysteine-tRNA ligase activity
DDW44_RS02370	COG0598	Magnesium transport protein CorA
DDW44_RS02380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDW44_RS02385	COG0667	Aldo Keto reductase
DDW44_RS02415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDW44_RS02430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDW44_RS02435	COG0564	pseudouridine synthase activity
DDW44_RS02450	COG1113	amino acid transport
DDW44_RS02455	COG2186	Transcriptional regulator
DDW44_RS02460	COG3265	gluconokinase activity
DDW44_RS02495	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DDW44_RS02500	COG2149	membrane
DDW44_RS02520	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS02535	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS02540	COG3876	Protein conserved in bacteria
DDW44_RS02575	COG0477	Major facilitator Superfamily
DDW44_RS02600	COG0243	molybdopterin cofactor binding
DDW44_RS02605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DDW44_RS02615	COG2188	Transcriptional regulator
DDW44_RS02625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDW44_RS02660	COG1492	cobalamin metabolic process
DDW44_RS02675	COG1797	cobyrinic acid a,c-diamide synthase activity
DDW44_RS02680	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DDW44_RS02715	COG1917	Cupin 2, conserved barrel domain protein
DDW44_RS02725	COG1902	pentaerythritol trinitrate reductase activity
DDW44_RS02730	COG1321	iron dependent repressor
DDW44_RS02745	COG0768	penicillin binding
DDW44_RS02755	COG2252	PERMEase
DDW44_RS02780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDW44_RS02790	COG2171	N-acyltransferase activity
DDW44_RS02795	COG3226	Transcriptional regulator
DDW44_RS02800	COG2076	Multidrug Resistance protein
DDW44_RS02810	COG0822	iron-sulfur transferase activity
DDW44_RS02815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDW44_RS02820	COG0396	ATPase activity
DDW44_RS02830	COG0719	Fe-S assembly protein
DDW44_RS02845	COG1131	(ABC) transporter
DDW44_RS02855	COG1612	heme a metabolic process
DDW44_RS02870	COG0109	protoheme IX farnesyltransferase activity
DDW44_RS02880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DDW44_RS02895	COG0363	glucosamine-6-phosphate deaminase activity
DDW44_RS02905	COG4195	phage-related replication protein
DDW44_RS02920	COG0166	Belongs to the GPI family
DDW44_RS02930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DDW44_RS02935	COG0149	triose-phosphate isomerase activity
DDW44_RS02940	COG0126	phosphoglycerate kinase activity
DDW44_RS02945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DDW44_RS02955	COG1481	regulation of sporulation
DDW44_RS02960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DDW44_RS02965	COG1660	Displays ATPase and GTPase activities
DDW44_RS02970	COG0322	excinuclease ABC activity
DDW44_RS02995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DDW44_RS03010	COG0477	Major facilitator Superfamily
DDW44_RS03030	COG0556	nucleotide-excision repair
DDW44_RS03035	COG5001	Diguanylate cyclase
DDW44_RS03035	COG3300	MHYT domain
DDW44_RS03040	COG0477	Major facilitator Superfamily
DDW44_RS03060	COG2313	pseudouridylate synthase activity
DDW44_RS03080	COG0436	Aminotransferase
DDW44_RS03100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DDW44_RS03105	COG0330	HflC and HflK could
DDW44_RS03130	COG0596	Alpha beta hydrolase
DDW44_RS03135	COG0237	dephospho-CoA kinase activity
DDW44_RS03145	COG0539	negative regulation of cytoplasmic translation
DDW44_RS03150	COG2226	methyltransferase
DDW44_RS03190	COG2050	protein possibly involved in aromatic compounds catabolism
DDW44_RS03195	COG2936	dipeptidyl-peptidase activity
DDW44_RS03255	COG0737	Belongs to the 5'-nucleotidase family
DDW44_RS03275	COG0287	Prephenate dehydrogenase
DDW44_RS03275	COG1605	Chorismate mutase
DDW44_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS03305	COG1024	Enoyl-CoA hydratase
DDW44_RS03335	COG1278	Cold shock
DDW44_RS03340	COG0183	Belongs to the thiolase family
DDW44_RS03345	COG1309	transcriptional regulator
DDW44_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS03355	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS03375	COG2304	oxidoreductase activity
DDW44_RS03385	COG0069	glutamate synthase activity
DDW44_RS03385	COG0070	glutamate synthase
DDW44_RS03385	COG0067	glutamate synthase
DDW44_RS03395	COG1397	ADP-ribosylglycohydrolase
DDW44_RS03415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDW44_RS03425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DDW44_RS03435	COG0159	tryptophan synthase activity
DDW44_RS03440	COG0133	tryptophan synthase activity
DDW44_RS03450	COG0134	indole-3-glycerol-phosphate synthase activity
DDW44_RS03475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DDW44_RS03490	COG0107	imidazoleglycerol-phosphate synthase activity
DDW44_RS03495	COG0251	oxidation-reduction process
DDW44_RS03500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DDW44_RS03505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DDW44_RS03510	COG0131	Imidazoleglycerol-phosphate dehydratase
DDW44_RS03515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDW44_RS03520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DDW44_RS03540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DDW44_RS03560	COG1432	Conserved Protein
DDW44_RS03565	COG0587	DNA-directed DNA polymerase activity
DDW44_RS03620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DDW44_RS03635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DDW44_RS03650	COG1799	cell septum assembly
DDW44_RS03655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DDW44_RS03675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DDW44_RS03680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DDW44_RS03690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DDW44_RS03695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DDW44_RS03705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DDW44_RS03710	COG0768	penicillin binding
DDW44_RS03725	COG0275	rRNA processing
DDW44_RS03745	COG0714	Associated with various cellular activities
DDW44_RS03770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DDW44_RS03790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DDW44_RS03800	COG1309	transcriptional regulator
DDW44_RS03805	COG1233	COG1233 Phytoene dehydrogenase and related
DDW44_RS03825	COG0352	thiamine-phosphate diphosphorylase activity
DDW44_RS03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDW44_RS03855	COG2022	thiamine diphosphate biosynthetic process
DDW44_RS03865	COG2022	thiamine diphosphate biosynthetic process
DDW44_RS03870	COG2815	serine threonine protein kinase
DDW44_RS03870	COG0515	serine threonine protein kinase
DDW44_RS03875	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DDW44_RS03880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DDW44_RS03885	COG2193	ferroxidase activity
DDW44_RS03895	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DDW44_RS03915	COG0205	6-phosphofructokinase activity
DDW44_RS03920	COG2197	response regulator
DDW44_RS03925	COG4585	Histidine kinase
DDW44_RS03950	COG1940	carbohydrate kinase activity
DDW44_RS03960	COG0003	Pfam Anion-transporting ATPase
DDW44_RS03985	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS04000	COG3883	PFAM NLP P60 protein
DDW44_RS04000	COG0791	NLP P60 protein
DDW44_RS04035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DDW44_RS04040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DDW44_RS04045	COG0723	plastoquinol--plastocyanin reductase activity
DDW44_RS04050	COG2010	Cytochrome c
DDW44_RS04055	COG1845	cytochrome c oxidase, subunit III
DDW44_RS04065	COG1376	ErfK ybiS ycfS ynhG family protein
DDW44_RS04075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DDW44_RS04080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DDW44_RS04090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDW44_RS04115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DDW44_RS04120	COG2197	response regulator
DDW44_RS04125	COG4585	Histidine kinase
DDW44_RS04150	COG2226	methyltransferase
DDW44_RS04155	COG1132	(ABC) transporter
DDW44_RS04170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DDW44_RS04185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DDW44_RS04200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DDW44_RS04205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDW44_RS04225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DDW44_RS04235	COG4221	oxidoreductase activity
DDW44_RS04255	COG1090	epimerase
DDW44_RS04270	COG0321	lipoyl(octanoyl) transferase activity
DDW44_RS04275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DDW44_RS04310	COG2205	protein histidine kinase activity
DDW44_RS04405	COG0366	Alpha amylase catalytic
DDW44_RS04410	COG3833	ABC-type maltose transport systems, permease component
DDW44_RS04415	COG1175	transmembrane transport
DDW44_RS04425	COG0366	Alpha amylase catalytic
DDW44_RS04430	COG1609	Transcriptional regulator
DDW44_RS04440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DDW44_RS04460	COG0174	glutamine synthetase
DDW44_RS04485	COG2267	carboxylic ester hydrolase activity
DDW44_RS04495	COG2132	Multicopper oxidase
DDW44_RS04500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DDW44_RS04500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDW44_RS04510	COG1309	transcriptional regulator
DDW44_RS04515	COG0477	Major facilitator Superfamily
DDW44_RS04520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DDW44_RS04530	COG1994	Peptidase M50
DDW44_RS04585	COG1834	amidinotransferase
DDW44_RS04600	COG2814	Major facilitator Superfamily
DDW44_RS04605	COG3540	Alkaline phosphatase
DDW44_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS04620	COG3387	PFAM Glycoside hydrolase 15-related
DDW44_RS04625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDW44_RS04645	COG1487	ribonuclease activity
DDW44_RS04695	COG3022	response to hydroperoxide
DDW44_RS04710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DDW44_RS04720	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS04730	COG2030	dehydratase
DDW44_RS04735	COG2197	response regulator
DDW44_RS04745	COG0183	Belongs to the thiolase family
DDW44_RS04785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDW44_RS04835	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS04840	COG1309	transcriptional regulator
DDW44_RS04885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDW44_RS04890	COG2304	oxidoreductase activity
DDW44_RS04950	COG0431	NADPH-dependent FMN reductase
DDW44_RS04970	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DDW44_RS04970	COG1672	PFAM Archaeal ATPase
DDW44_RS04980	COG0475	glutathione-regulated potassium exporter activity
DDW44_RS05010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDW44_RS05025	COG2813	Specifically methylates the guanine in position
DDW44_RS05065	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS05095	COG0183	Belongs to the thiolase family
DDW44_RS05135	COG0598	Magnesium transport protein CorA
DDW44_RS05140	COG2259	Doxx family
DDW44_RS05155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DDW44_RS05160	COG0581	inorganic phosphate transmembrane transporter activity
DDW44_RS05165	COG0573	inorganic phosphate transmembrane transporter activity
DDW44_RS05170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DDW44_RS05185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDW44_RS05195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DDW44_RS05195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DDW44_RS05210	COG0297	glycogen (starch) synthase activity
DDW44_RS05295	COG0717	Belongs to the dCTP deaminase family
DDW44_RS05315	COG0247	lactate metabolic process
DDW44_RS05315	COG2181	nitrate reductase activity
DDW44_RS05325	COG0443	Heat shock 70 kDa protein
DDW44_RS05330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DDW44_RS05335	COG0484	heat shock protein binding
DDW44_RS05340	COG0789	Transcriptional regulator
DDW44_RS05360	COG0542	response to heat
DDW44_RS05415	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DDW44_RS05430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DDW44_RS05435	COG0191	fructose-bisphosphate aldolase activity
DDW44_RS05445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DDW44_RS05450	COG0477	Major facilitator Superfamily
DDW44_RS05460	COG3483	tryptophan 2,3-dioxygenase activity
DDW44_RS05465	COG3844	kynureninase activity
DDW44_RS05480	COG4585	Histidine kinase
DDW44_RS05485	COG2197	response regulator
DDW44_RS05500	COG2124	cytochrome p450
DDW44_RS05505	COG3559	Exporter of polyketide antibiotics
DDW44_RS05510	COG1131	(ABC) transporter
DDW44_RS05525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DDW44_RS05565	COG3655	Transcriptional regulator
DDW44_RS05595	COG3845	ABC transporter
DDW44_RS05610	COG0183	Belongs to the thiolase family
DDW44_RS05615	COG2124	cytochrome p450
DDW44_RS05640	COG4122	O-methyltransferase activity
DDW44_RS05655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DDW44_RS05675	COG3409	Peptidoglycan-binding domain 1 protein
DDW44_RS05675	COG0860	N-Acetylmuramoyl-L-alanine amidase
DDW44_RS05680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DDW44_RS05690	COG0390	transport system, permease component
DDW44_RS05775	COG2208	phosphoserine phosphatase activity
DDW44_RS05775	COG2770	Histidine kinase
DDW44_RS05780	COG0596	Alpha beta hydrolase
DDW44_RS05810	COG1857	crispr-associated protein
DDW44_RS05825	COG1518	maintenance of DNA repeat elements
DDW44_RS05830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DDW44_RS05925	COG0582	viral genome integration into host DNA
DDW44_RS05955	COG1358	cellular component organization or biogenesis
DDW44_RS06000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DDW44_RS06005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDW44_RS06030	COG0667	Aldo Keto reductase
DDW44_RS06035	COG0789	Transcriptional regulator
DDW44_RS06060	COG1278	Cold shock
DDW44_RS06070	COG1741	Belongs to the pirin family
DDW44_RS06085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDW44_RS06090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDW44_RS06095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDW44_RS06115	COG1764	response to oxidative stress
DDW44_RS06120	COG2130	NADP-dependent
DDW44_RS06145	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS06150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DDW44_RS06150	COG0825	malonyl-CoA metabolic process
DDW44_RS06170	COG0477	Major facilitator Superfamily
DDW44_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS06180	COG3237	CsbD-like
DDW44_RS06185	COG1231	oxidoreductase activity
DDW44_RS06205	COG1121	(ABC) transporter
DDW44_RS06210	COG0803	Belongs to the bacterial solute-binding protein 9 family
DDW44_RS06220	COG0701	Predicted permease
DDW44_RS06230	COG2070	2-Nitropropane dioxygenase
DDW44_RS06235	COG0655	NAD(P)H dehydrogenase (quinone) activity
DDW44_RS06240	COG1309	transcriptional regulator
DDW44_RS06255	COG4948	Mandelate Racemase Muconate Lactonizing
DDW44_RS06275	COG0531	amino acid
DDW44_RS06290	COG2197	response regulator
DDW44_RS06315	COG1672	PFAM Archaeal ATPase
DDW44_RS06315	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DDW44_RS06350	COG1070	Carbohydrate kinase
DDW44_RS06385	COG0588	phosphoglycerate mutase activity
DDW44_RS06400	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS06480	COG1490	D-aminoacyl-tRNA deacylase activity
DDW44_RS06485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DDW44_RS06495	COG3485	protocatechuate 3,4-dioxygenase
DDW44_RS06520	COG2897	thiosulfate sulfurtransferase activity
DDW44_RS06550	COG0745	RESPONSE REGULATOR receiver
DDW44_RS06555	COG1609	Transcriptional regulator
DDW44_RS06560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDW44_RS06565	COG0745	RESPONSE REGULATOR receiver
DDW44_RS06580	COG0737	Belongs to the 5'-nucleotidase family
DDW44_RS06585	COG0456	acetyltransferase
DDW44_RS06595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DDW44_RS06605	COG0494	nUDIX hydrolase
DDW44_RS06605	COG0406	alpha-ribazole phosphatase activity
DDW44_RS06630	COG0306	phosphate transporter
DDW44_RS06640	COG1937	Protein conserved in bacteria
DDW44_RS06650	COG0671	phosphoesterase, PA-phosphatase related
DDW44_RS06655	COG1196	nuclear chromosome segregation
DDW44_RS06655	COG0741	lytic transglycosylase activity
DDW44_RS06655	COG0739	heme binding
DDW44_RS06735	COG1252	NADH dehydrogenase
DDW44_RS06750	COG3293	Transposase
DDW44_RS06770	COG0579	oxidoreductase
DDW44_RS06775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DDW44_RS06820	COG1404	Belongs to the peptidase S8 family
DDW44_RS06845	COG0513	Belongs to the DEAD box helicase family
DDW44_RS06905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DDW44_RS06905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DDW44_RS06920	COG2755	lipolytic protein G-D-S-L family
DDW44_RS06930	COG1216	Glycosyl transferase, family 2
DDW44_RS06945	COG1725	Transcriptional regulator
DDW44_RS06950	COG0456	acetyltransferase
DDW44_RS06960	COG2226	methyltransferase
DDW44_RS06980	COG4565	transcriptional regulatory protein
DDW44_RS07005	COG0587	DNA-directed DNA polymerase activity
DDW44_RS07040	COG0641	radical SAM
DDW44_RS07070	COG1799	cell septum assembly
DDW44_RS07075	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS07080	COG0477	Major facilitator Superfamily
DDW44_RS07085	COG0671	phosphoesterase, PA-phosphatase related
DDW44_RS07105	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS07120	COG1160	GTP binding
DDW44_RS07130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DDW44_RS07165	COG0346	lactoylglutathione lyase activity
DDW44_RS07210	COG1397	ADP-ribosylglycohydrolase
DDW44_RS07215	COG0494	nUDIX hydrolase
DDW44_RS07235	COG1187	pseudouridine synthase activity
DDW44_RS07240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DDW44_RS07245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DDW44_RS07260	COG0686	Belongs to the AlaDH PNT family
DDW44_RS07270	COG0494	nUDIX hydrolase
DDW44_RS07275	COG0504	CTP synthase activity
DDW44_RS07280	COG3387	PFAM Glycoside hydrolase 15-related
DDW44_RS07295	COG0297	glycogen (starch) synthase activity
DDW44_RS07300	COG0497	DNA recombination
DDW44_RS07305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DDW44_RS07325	COG1120	ATPase activity
DDW44_RS07330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDW44_RS07335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDW44_RS07340	COG0647	UMP catabolic process
DDW44_RS07380	COG2094	Belongs to the DNA glycosylase MPG family
DDW44_RS07390	COG1881	PFAM PEBP family protein
DDW44_RS07415	COG1119	ATPase activity
DDW44_RS07430	COG2197	response regulator
DDW44_RS07435	COG4585	Histidine kinase
DDW44_RS07440	COG4221	oxidoreductase activity
DDW44_RS07445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DDW44_RS07455	COG0842	Transport permease protein
DDW44_RS07455	COG1716	ATPase activity
DDW44_RS07455	COG1131	(ABC) transporter
DDW44_RS07465	COG0477	Major facilitator Superfamily
DDW44_RS07470	COG0560	Phosphoserine phosphatase
DDW44_RS07470	COG3830	Belongs to the UPF0237 family
DDW44_RS07475	COG0588	phosphoglycerate mutase activity
DDW44_RS07490	COG2186	Transcriptional regulator
DDW44_RS07500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DDW44_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS07540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DDW44_RS07560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DDW44_RS07565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDW44_RS07580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDW44_RS07585	COG1846	Transcriptional regulator
DDW44_RS07610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DDW44_RS07625	COG3387	PFAM Glycoside hydrolase 15-related
DDW44_RS07690	COG0488	(ABC) transporter
DDW44_RS07715	COG0235	Class ii aldolase
DDW44_RS07745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DDW44_RS07750	COG0358	DNA primase activity
DDW44_RS07760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DDW44_RS07775	COG2949	membrane
DDW44_RS07780	COG0243	molybdopterin cofactor binding
DDW44_RS07825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDW44_RS07830	COG2146	nitrite reductase [NAD(P)H] activity
DDW44_RS07830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDW44_RS07835	COG2146	nitrite reductase [NAD(P)H] activity
DDW44_RS07835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DDW44_RS07840	COG2318	DinB family
DDW44_RS07865	COG0574	Belongs to the PEP-utilizing enzyme family
DDW44_RS07865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDW44_RS07890	COG0667	Aldo Keto reductase
DDW44_RS07895	COG1309	transcriptional regulator
DDW44_RS07905	COG0423	glycine-tRNA ligase activity
DDW44_RS07910	COG0803	Belongs to the bacterial solute-binding protein 9 family
DDW44_RS07910	COG3443	Belongs to the bacterial solute-binding protein 9 family
DDW44_RS07915	COG1121	(ABC) transporter
DDW44_RS07920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDW44_RS07930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DDW44_RS07935	COG1381	Involved in DNA repair and RecF pathway recombination
DDW44_RS07960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDW44_RS07975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DDW44_RS07995	COG2315	Protein conserved in bacteria
DDW44_RS08005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DDW44_RS08030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDW44_RS08035	COG1234	tRNA 3'-trailer cleavage
DDW44_RS08040	COG0537	adenosine 5'-monophosphoramidase activity
DDW44_RS08060	COG0484	heat shock protein binding
DDW44_RS08065	COG1420	regulation of RNA biosynthetic process
DDW44_RS08080	COG2318	DinB family
DDW44_RS08100	COG0481	GTPase activity
DDW44_RS08105	COG0268	Binds directly to 16S ribosomal RNA
DDW44_RS08120	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DDW44_RS08130	COG1234	tRNA 3'-trailer cleavage
DDW44_RS08135	COG1555	photosystem II stabilization
DDW44_RS08140	COG1307	EDD domain protein, DegV family
DDW44_RS08150	COG0495	leucyl-tRNA aminoacylation
DDW44_RS08190	COG0799	negative regulation of ribosome biogenesis
DDW44_RS08200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DDW44_RS08205	COG0501	Belongs to the peptidase M48B family
DDW44_RS08220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DDW44_RS08230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DDW44_RS08245	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS08250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DDW44_RS08255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DDW44_RS08260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DDW44_RS08305	COG0673	inositol 2-dehydrogenase activity
DDW44_RS08315	COG1530	ribonuclease E activity
DDW44_RS08335	COG0772	Belongs to the SEDS family
DDW44_RS08355	COG1077	Cell shape determining protein MreB Mrl
DDW44_RS08360	COG0105	UTP biosynthetic process
DDW44_RS08370	COG0285	dihydrofolate synthase activity
DDW44_RS08375	COG0525	valine-tRNA ligase activity
DDW44_RS08385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DDW44_RS08390	COG0740	serine-type endopeptidase activity
DDW44_RS08395	COG0740	serine-type endopeptidase activity
DDW44_RS08400	COG0544	peptidyl-prolyl cis-trans isomerase activity
DDW44_RS08420	COG3594	Acyltransferase
DDW44_RS08435	COG4552	Acetyltransferase involved in intracellular survival and related
DDW44_RS08445	COG0698	ribose 5-phosphate isomerase
DDW44_RS08455	COG1113	amino acid transport
DDW44_RS08460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DDW44_RS08465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DDW44_RS08520	COG0697	spore germination
DDW44_RS08525	COG1846	Transcriptional regulator
DDW44_RS08545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DDW44_RS08545	COG3291	Pkd domain containing protein
DDW44_RS08555	COG0668	transmembrane transport
DDW44_RS08570	COG1486	melibiose metabolic process
DDW44_RS08585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDW44_RS08615	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDW44_RS08620	COG2346	COG2346, Truncated hemoglobins
DDW44_RS08745	COG1131	(ABC) transporter
DDW44_RS08760	COG3962	Belongs to the TPP enzyme family
DDW44_RS08765	COG3718	enzyme involved in inositol metabolism
DDW44_RS08775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDW44_RS08800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DDW44_RS08810	COG1472	Belongs to the glycosyl hydrolase 3 family
DDW44_RS08855	COG0028	Belongs to the TPP enzyme family
DDW44_RS08865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDW44_RS08880	COG3321	synthase
DDW44_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS08880	COG0604	alcohol dehydrogenase
DDW44_RS08940	COG1946	Acyl-CoA thioesterase
DDW44_RS08945	COG0596	Alpha beta hydrolase
DDW44_RS08960	COG1309	transcriptional regulator
DDW44_RS08965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDW44_RS08980	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS08995	COG0076	glutamate decarboxylase activity
DDW44_RS09000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DDW44_RS09020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDW44_RS09030	COG0589	response to stress
DDW44_RS09040	COG4977	sequence-specific DNA binding
DDW44_RS09045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DDW44_RS09125	COG2226	methyltransferase
DDW44_RS09185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDW44_RS09205	COG0154	amidase activity
DDW44_RS09220	COG0765	amino acid transport
DDW44_RS09225	COG0765	amino acid transport
DDW44_RS09230	COG1126	abc transporter atp-binding protein
DDW44_RS09385	COG0673	inositol 2-dehydrogenase activity
DDW44_RS09390	COG4702	Belongs to the UPF0303 family
DDW44_RS09395	COG0179	Fumarylacetoacetate (FAA) hydrolase
DDW44_RS09400	COG0706	membrane insertase activity
DDW44_RS09415	COG0556	nucleotide-excision repair
DDW44_RS09425	COG1254	Belongs to the acylphosphatase family
DDW44_RS09440	COG2733	membrane
DDW44_RS09470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDW44_RS09485	COG4555	ABC transporter
DDW44_RS09510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DDW44_RS09520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DDW44_RS09525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DDW44_RS09530	COG1263	PTS System
DDW44_RS09535	COG1263	PTS System
DDW44_RS09550	COG1234	tRNA 3'-trailer cleavage
DDW44_RS09585	COG2409	Drug exporters of the RND superfamily
DDW44_RS09595	COG1113	amino acid transport
DDW44_RS09605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DDW44_RS09615	COG1335	isochorismatase
DDW44_RS09655	COG0277	FAD linked oxidase domain protein
DDW44_RS09665	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DDW44_RS09675	COG3480	Lon protease (S16) C-terminal proteolytic domain
DDW44_RS09700	COG1051	belongs to the nudix hydrolase family
DDW44_RS09705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DDW44_RS09710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDW44_RS09720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DDW44_RS09735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDW44_RS09755	COG1678	Uncharacterized ACR, COG1678
DDW44_RS09760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DDW44_RS09765	COG0776	regulation of translation
DDW44_RS09775	COG3973	AAA domain
DDW44_RS09800	COG2223	nitrite transmembrane transporter activity
DDW44_RS09820	COG0583	DNA-binding transcription factor activity
DDW44_RS09850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DDW44_RS09855	COG0793	Belongs to the peptidase S41A family
DDW44_RS09865	COG2884	Cell division ATP-binding protein ftsE
DDW44_RS09950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DDW44_RS09955	COG0515	serine threonine protein kinase
DDW44_RS09960	COG0515	serine threonine protein kinase
DDW44_RS09970	COG1653	transport
DDW44_RS09975	COG1175	transmembrane transport
DDW44_RS09980	COG0395	ABC-type sugar transport system, permease component
DDW44_RS09995	COG1309	transcriptional regulator
DDW44_RS10005	COG1134	teichoic acid transport
DDW44_RS10005	COG1388	LysM domain
DDW44_RS10010	COG4941	Belongs to the sigma-70 factor family
DDW44_RS10015	COG3795	YCII-related domain
DDW44_RS10025	COG2902	Dehydrogenase
DDW44_RS10035	COG0546	phosphoglycolate phosphatase activity
DDW44_RS10050	COG0653	protein targeting
DDW44_RS10060	COG3214	Protein conserved in bacteria
DDW44_RS10065	COG2197	response regulator
DDW44_RS10070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DDW44_RS10080	COG0823	Involved in the tonB-independent uptake of proteins
DDW44_RS10085	COG5002	protein histidine kinase activity
DDW44_RS10085	COG5000	phosphorelay sensor kinase activity
DDW44_RS10090	COG0745	RESPONSE REGULATOR receiver
DDW44_RS10095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DDW44_RS10115	COG0714	Associated with various cellular activities
DDW44_RS10155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DDW44_RS10175	COG2835	tetraacyldisaccharide 4'-kinase activity
DDW44_RS10180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DDW44_RS10215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DDW44_RS10220	COG0778	Nitroreductase
DDW44_RS10220	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DDW44_RS10245	COG1316	TRANSCRIPTIONal
DDW44_RS10265	COG1316	TRANSCRIPTIONal
DDW44_RS10270	COG1607	acyl-coa hydrolase
DDW44_RS10275	COG1316	TRANSCRIPTIONal
DDW44_RS10300	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS10305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DDW44_RS10325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DDW44_RS10340	COG2205	protein histidine kinase activity
DDW44_RS10345	COG0745	RESPONSE REGULATOR receiver
DDW44_RS10350	COG3104	oligopeptide transport
DDW44_RS10380	COG1191	sigma factor activity
DDW44_RS10385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DDW44_RS10420	COG0804	urea catabolic process
DDW44_RS10425	COG0832	Belongs to the urease beta subunit family
DDW44_RS10430	COG0831	urea catabolic process
DDW44_RS10435	COG1309	transcriptional regulator
DDW44_RS10450	COG0740	serine-type endopeptidase activity
DDW44_RS10485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DDW44_RS10490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDW44_RS10495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DDW44_RS10535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DDW44_RS10555	COG1940	carbohydrate kinase activity
DDW44_RS10560	COG2188	Transcriptional regulator
DDW44_RS10565	COG1595	DNA-templated transcription, initiation
DDW44_RS10570	COG2267	carboxylic ester hydrolase activity
DDW44_RS10590	COG0626	cystathionine gamma-synthase activity
DDW44_RS10615	COG1522	sequence-specific DNA binding
DDW44_RS10620	COG0419	ATPase involved in DNA repair
DDW44_RS10625	COG0420	3'-5' exonuclease activity
DDW44_RS10630	COG1739	Uncharacterized protein family UPF0029
DDW44_RS10635	COG2826	transposase and inactivated derivatives, IS30 family
DDW44_RS10640	COG1832	CoA-binding protein
DDW44_RS10650	COG1396	sequence-specific DNA binding
DDW44_RS10705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DDW44_RS10720	COG1968	undecaprenyl-diphosphatase activity
DDW44_RS10735	COG0531	amino acid
DDW44_RS10745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DDW44_RS10770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DDW44_RS10820	COG0697	spore germination
DDW44_RS10845	COG1695	Transcriptional regulator
DDW44_RS10875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDW44_RS10875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DDW44_RS10885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DDW44_RS10905	COG1716	ATPase activity
DDW44_RS10925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DDW44_RS10955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DDW44_RS10965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DDW44_RS10980	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DDW44_RS10995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DDW44_RS11000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DDW44_RS11060	COG2814	Major facilitator Superfamily
DDW44_RS11065	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DDW44_RS11070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DDW44_RS11075	COG1984	allophanate hydrolase subunit 2
DDW44_RS11085	COG2755	lipolytic protein G-D-S-L family
DDW44_RS11090	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS11120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDW44_RS11135	COG2270	Major facilitator Superfamily
DDW44_RS11145	COG3030	protein affecting phage T7 exclusion by the F plasmid
DDW44_RS11150	COG1216	Glycosyl transferase, family 2
DDW44_RS11175	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS11215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DDW44_RS11220	COG0140	phosphoribosyl-ATP diphosphatase activity
DDW44_RS11225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DDW44_RS11230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDW44_RS11230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DDW44_RS11235	COG3201	nicotinamide mononucleotide transporter
DDW44_RS11250	COG1846	Transcriptional regulator
DDW44_RS11250	COG1940	carbohydrate kinase activity
DDW44_RS11255	COG2223	nitrite transmembrane transporter activity
DDW44_RS11260	COG2233	PERMEase
DDW44_RS11280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDW44_RS11290	COG0531	amino acid
DDW44_RS11330	COG2390	Transcriptional regulator
DDW44_RS11335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DDW44_RS11345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DDW44_RS11365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DDW44_RS11380	COG0194	GDP metabolic process
DDW44_RS11390	COG0284	orotidine-5'-phosphate decarboxylase activity
DDW44_RS11395	COG0167	dihydroorotate dehydrogenase activity
DDW44_RS11400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DDW44_RS11405	COG0505	Belongs to the CarA family
DDW44_RS11415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDW44_RS11420	COG0540	Belongs to the ATCase OTCase family
DDW44_RS11425	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DDW44_RS11435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DDW44_RS11440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DDW44_RS11445	COG0006	proline dipeptidase activity
DDW44_RS11455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DDW44_RS11460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DDW44_RS11465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DDW44_RS11470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DDW44_RS11475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DDW44_RS11480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DDW44_RS11490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DDW44_RS11495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DDW44_RS11510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DDW44_RS11530	COG0124	histidyl-tRNA synthetase
DDW44_RS11545	COG1196	nuclear chromosome segregation
DDW44_RS11550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DDW44_RS11555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DDW44_RS11560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDW44_RS11565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDW44_RS11575	COG2255	four-way junction helicase activity
DDW44_RS11580	COG0632	four-way junction helicase activity
DDW44_RS11585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DDW44_RS11590	COG0217	transcriptional regulatory protein
DDW44_RS11595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DDW44_RS11600	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DDW44_RS11610	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS11615	COG1560	Kdo2-lipid A biosynthetic process
DDW44_RS11620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DDW44_RS11640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDW44_RS11645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DDW44_RS11660	COG2176	DNA-directed DNA polymerase activity
DDW44_RS11660	COG5002	protein histidine kinase activity
DDW44_RS11710	COG1228	amidohydrolase
DDW44_RS11715	COG3467	pyridoxamine 5'-phosphate
DDW44_RS11740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DDW44_RS11745	COG0019	diaminopimelate decarboxylase activity
DDW44_RS11795	COG2755	lipolytic protein G-D-S-L family
DDW44_RS11800	COG0183	Belongs to the thiolase family
DDW44_RS11835	COG1136	(ABC) transporter
DDW44_RS11835	COG0577	efflux transmembrane transporter activity
DDW44_RS11840	COG0577	efflux transmembrane transporter activity
DDW44_RS11840	COG1136	(ABC) transporter
DDW44_RS11845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DDW44_RS11850	COG1252	NADH dehydrogenase
DDW44_RS11870	COG0148	phosphopyruvate hydratase activity
DDW44_RS11880	COG1652	LysM domain
DDW44_RS11975	COG1595	DNA-templated transcription, initiation
DDW44_RS11985	COG0577	efflux transmembrane transporter activity
DDW44_RS11990	COG0577	efflux transmembrane transporter activity
DDW44_RS11990	COG1136	(ABC) transporter
DDW44_RS11995	COG0477	Major facilitator Superfamily
DDW44_RS12005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDW44_RS12010	COG2226	methyltransferase
DDW44_RS12040	COG4585	Histidine kinase
DDW44_RS12055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DDW44_RS12060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DDW44_RS12065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DDW44_RS12070	COG0193	aminoacyl-tRNA hydrolase activity
DDW44_RS12080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DDW44_RS12100	COG4106	trans-aconitate 2-methyltransferase activity
DDW44_RS12105	COG1846	Transcriptional regulator
DDW44_RS12110	COG2197	response regulator
DDW44_RS12120	COG3547	Transposase (IS116 IS110 IS902 family)
DDW44_RS12150	COG0488	(ABC) transporter
DDW44_RS12170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DDW44_RS12175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DDW44_RS12185	COG0084	hydrolase, TatD family'
DDW44_RS12275	COG0442	prolyl-tRNA aminoacylation
DDW44_RS12285	COG1122	ATPase activity
DDW44_RS12295	COG0310	cobalt ion transport
DDW44_RS12305	COG2409	Drug exporters of the RND superfamily
DDW44_RS12315	COG0793	Belongs to the peptidase S41A family
DDW44_RS12315	COG4946	Tricorn protease homolog
DDW44_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS12330	COG2267	carboxylic ester hydrolase activity
DDW44_RS12335	COG2072	flavoprotein involved in K transport
DDW44_RS12345	COG0708	Exodeoxyribonuclease III
DDW44_RS12360	COG4989	oxidoreductase activity
DDW44_RS12410	COG0521	Mo-molybdopterin cofactor biosynthetic process
DDW44_RS12410	COG0315	cyclic pyranopterin monophosphate synthase activity
DDW44_RS12415	COG0315	cyclic pyranopterin monophosphate synthase activity
DDW44_RS12425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DDW44_RS12430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DDW44_RS12440	COG3263	regulation of cellular component size
DDW44_RS12470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DDW44_RS12530	COG3191	aminopeptidase activity
DDW44_RS12545	COG1105	Belongs to the carbohydrate kinase PfkB family
DDW44_RS12550	COG1349	DNA-binding transcription factor activity
DDW44_RS12555	COG0477	Major facilitator Superfamily
DDW44_RS12560	COG2378	regulation of single-species biofilm formation
DDW44_RS12570	COG3384	dioxygenase
DDW44_RS12575	COG1846	Transcriptional regulator
DDW44_RS12625	COG4585	Histidine kinase
DDW44_RS12630	COG2197	response regulator
DDW44_RS12635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DDW44_RS12720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DDW44_RS12725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDW44_RS12730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DDW44_RS12745	COG1414	Transcriptional regulator
DDW44_RS12750	COG4638	Rieske (2fe-2S)
DDW44_RS12760	COG0492	ferredoxin-NADP+ reductase activity
DDW44_RS12780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDW44_RS12785	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS12795	COG0444	Belongs to the ABC transporter superfamily
DDW44_RS12800	COG0601	transmembrane transport
DDW44_RS12805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDW44_RS12810	COG4166	transmembrane transport
DDW44_RS12825	COG0583	DNA-binding transcription factor activity
DDW44_RS12830	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDW44_RS12835	COG2086	electron transfer activity
DDW44_RS12840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DDW44_RS12845	COG2095	MarC family integral membrane protein
DDW44_RS12865	COG1686	Belongs to the peptidase S11 family
DDW44_RS12900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDW44_RS13025	COG0596	Alpha beta hydrolase
DDW44_RS13080	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS13095	COG1024	Enoyl-CoA hydratase
DDW44_RS13115	COG1309	transcriptional regulator
DDW44_RS13125	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS13140	COG0259	pyridoxamine-phosphate oxidase activity
DDW44_RS13180	COG2072	flavoprotein involved in K transport
DDW44_RS13195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DDW44_RS13200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DDW44_RS13210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DDW44_RS13215	COG0640	Transcriptional regulator
DDW44_RS13225	COG1024	Enoyl-CoA hydratase
DDW44_RS13235	COG0135	phosphoribosylanthranilate isomerase activity
DDW44_RS13240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DDW44_RS13245	COG2271	Major facilitator Superfamily
DDW44_RS13260	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS13280	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS13285	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS13295	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS13315	COG1366	Belongs to the anti-sigma-factor antagonist family
DDW44_RS13355	COG1131	(ABC) transporter
DDW44_RS13370	COG2945	thiolester hydrolase activity
DDW44_RS13370	COG0596	Alpha beta hydrolase
DDW44_RS13385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDW44_RS13405	COG4821	SIS domain
DDW44_RS13415	COG0259	pyridoxamine-phosphate oxidase activity
DDW44_RS13450	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS13465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDW44_RS13485	COG0583	DNA-binding transcription factor activity
DDW44_RS13490	COG0561	phosphatase activity
DDW44_RS13500	COG0277	FAD linked oxidase domain protein
DDW44_RS13500	COG0247	lactate metabolic process
DDW44_RS13505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DDW44_RS13545	COG0667	Aldo Keto reductase
DDW44_RS13570	COG2252	PERMEase
DDW44_RS13580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DDW44_RS13600	COG2814	Major facilitator Superfamily
DDW44_RS13610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DDW44_RS13615	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DDW44_RS13620	COG1278	Cold shock
DDW44_RS13645	COG1061	Type III restriction enzyme res subunit
DDW44_RS13660	COG3973	AAA domain
DDW44_RS13700	COG2826	transposase and inactivated derivatives, IS30 family
DDW44_RS13705	COG1737	Transcriptional regulator
DDW44_RS13710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DDW44_RS13715	COG2755	lipolytic protein G-D-S-L family
DDW44_RS13720	COG1136	(ABC) transporter
DDW44_RS13730	COG2890	protein-(glutamine-N5) methyltransferase activity
DDW44_RS13760	COG4191	Histidine kinase
DDW44_RS13770	COG1278	Cold shock
DDW44_RS13780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DDW44_RS13785	COG0463	Glycosyl transferase, family 2
DDW44_RS13795	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DDW44_RS13845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DDW44_RS13875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDW44_RS13915	COG1132	(ABC) transporter
DDW44_RS13975	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DDW44_RS13980	COG2188	Transcriptional regulator
DDW44_RS14040	COG3842	ATPase activity
DDW44_RS14050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DDW44_RS14065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDW44_RS14070	COG0215	cysteine-tRNA ligase activity
DDW44_RS14075	COG3467	pyridoxamine 5'-phosphate
DDW44_RS14080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DDW44_RS14085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DDW44_RS14090	COG1329	Transcriptional regulator
DDW44_RS14110	COG5002	protein histidine kinase activity
DDW44_RS14125	COG1643	Atp-dependent helicase
DDW44_RS14160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DDW44_RS14190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DDW44_RS14195	COG0047	phosphoribosylformylglycinamidine synthase activity
DDW44_RS14200	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DDW44_RS14230	COG3851	Histidine kinase
DDW44_RS14245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DDW44_RS14260	COG0151	Belongs to the GarS family
DDW44_RS14380	COG2826	transposase and inactivated derivatives, IS30 family
DDW44_RS14405	COG0433	COG0433 Predicted ATPase
DDW44_RS14420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DDW44_RS14450	COG1191	sigma factor activity
DDW44_RS14455	COG1191	sigma factor activity
DDW44_RS14470	COG1846	Transcriptional regulator
DDW44_RS14480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DDW44_RS14480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DDW44_RS14490	COG2205	protein histidine kinase activity
DDW44_RS14495	COG0745	RESPONSE REGULATOR receiver
DDW44_RS14515	COG0494	nUDIX hydrolase
DDW44_RS14560	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS14565	COG1595	DNA-templated transcription, initiation
DDW44_RS14645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDW44_RS14660	COG0653	protein targeting
DDW44_RS14675	COG0006	proline dipeptidase activity
DDW44_RS14695	COG1999	signal sequence binding
DDW44_RS14715	COG2837	iron assimilation
DDW44_RS14725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DDW44_RS14730	COG0561	phosphatase activity
DDW44_RS14750	COG1131	(ABC) transporter
DDW44_RS14760	COG1131	(ABC) transporter
DDW44_RS14775	COG0789	Transcriptional regulator
DDW44_RS14780	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DDW44_RS14790	COG0561	phosphatase activity
DDW44_RS14795	COG1196	nuclear chromosome segregation
DDW44_RS14795	COG0739	heme binding
DDW44_RS14795	COG0741	lytic transglycosylase activity
DDW44_RS14800	COG4988	ABC transporter
DDW44_RS14805	COG1294	oxidase, subunit
DDW44_RS14810	COG1271	oxidase subunit
DDW44_RS14815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDW44_RS14820	COG1609	Transcriptional regulator
DDW44_RS14835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DDW44_RS14860	COG0662	Cupin 2, conserved barrel domain protein
DDW44_RS14865	COG1950	PFAM Membrane protein of
DDW44_RS14870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DDW44_RS14875	COG0626	cystathionine gamma-synthase activity
DDW44_RS14900	COG2814	Major facilitator Superfamily
DDW44_RS14910	COG0456	acetyltransferase
DDW44_RS14920	COG0305	Participates in initiation and elongation during chromosome replication
DDW44_RS14930	COG0359	binds to the 23S rRNA
DDW44_RS14935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DDW44_RS14940	COG0629	single-stranded DNA binding
DDW44_RS14945	COG0360	Binds together with S18 to 16S ribosomal RNA
DDW44_RS14970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDW44_RS14980	COG1260	myo-inositol-1-phosphate synthase
DDW44_RS14990	COG0617	tRNA 3'-terminal CCA addition
DDW44_RS15005	COG2815	serine threonine protein kinase
DDW44_RS15005	COG0515	serine threonine protein kinase
DDW44_RS15010	COG1595	DNA-templated transcription, initiation
DDW44_RS15020	COG0492	ferredoxin-NADP+ reductase activity
DDW44_RS15025	COG3118	belongs to the thioredoxin family
DDW44_RS15040	COG1192	Involved in chromosome partitioning
DDW44_RS15045	COG0357	Ribosomal RNA small subunit methyltransferase G
DDW44_RS15055	COG0706	membrane insertase activity
DDW44_RS15060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DDW44_RS15065	COG0594	ribonuclease P activity
DDW44_RS15070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DDW44_RS15090	COG0592	DNA-directed DNA polymerase activity
DDW44_RS15095	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DDW44_RS15100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DDW44_RS15105	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DDW44_RS15115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDW44_RS15140	COG0515	serine threonine protein kinase
DDW44_RS15175	COG4106	trans-aconitate 2-methyltransferase activity
DDW44_RS15195	COG2890	protein-(glutamine-N5) methyltransferase activity
DDW44_RS15205	COG0251	oxidation-reduction process
DDW44_RS15230	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS15260	COG0705	Rhomboid family
DDW44_RS15275	COG3764	Sortase (surface protein transpeptidase)
DDW44_RS15285	COG3764	Sortase (surface protein transpeptidase)
DDW44_RS15290	COG3764	Sortase (surface protein transpeptidase)
DDW44_RS15295	COG0515	serine threonine protein kinase
DDW44_RS15300	COG0768	penicillin binding
DDW44_RS15315	COG1716	ATPase activity
DDW44_RS15320	COG1716	ATPase activity
DDW44_RS15330	COG4585	Histidine kinase
DDW44_RS15335	COG2197	response regulator
DDW44_RS15355	COG0500	methyltransferase
DDW44_RS15365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DDW44_RS15370	COG2151	metal-sulfur cluster biosynthetic enzyme
DDW44_RS15375	COG3396	Phenylacetate-CoA oxygenase
DDW44_RS15380	COG3460	Phenylacetate-CoA oxygenase
DDW44_RS15385	COG3396	Phenylacetate-CoA oxygenase
DDW44_RS15410	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDW44_RS15415	COG1309	transcriptional regulator
DDW44_RS15420	COG1522	sequence-specific DNA binding
DDW44_RS15445	COG0303	'Molybdopterin
DDW44_RS15450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDW44_RS15455	COG0604	alcohol dehydrogenase
DDW44_RS15470	COG4591	ABC-type transport system involved in lipoprotein release permease component
DDW44_RS15470	COG1136	(ABC) transporter
DDW44_RS15485	COG0515	serine threonine protein kinase
DDW44_RS15490	COG0515	serine threonine protein kinase
DDW44_RS15510	COG0022	dehydrogenase e1 component
DDW44_RS15515	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDW44_RS15525	COG1802	Transcriptional regulator
DDW44_RS15530	COG2271	Major facilitator Superfamily
DDW44_RS15590	COG1362	aminopeptidase activity
DDW44_RS15595	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS15610	COG1741	Belongs to the pirin family
DDW44_RS15635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DDW44_RS15650	COG0387	Pfam Sodium calcium exchanger
DDW44_RS15660	COG2070	2-Nitropropane dioxygenase
DDW44_RS15665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DDW44_RS15675	COG4977	sequence-specific DNA binding
DDW44_RS15690	COG0515	serine threonine protein kinase
DDW44_RS15720	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS15785	COG2376	Dihydroxyacetone kinase
DDW44_RS15790	COG1461	Dihydroxyacetone kinase
DDW44_RS15795	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DDW44_RS15800	COG0310	cobalt ion transport
DDW44_RS15805	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
DDW44_RS15815	COG1122	ATPase activity
DDW44_RS15820	COG0446	pyridine nucleotide-disulphide oxidoreductase
DDW44_RS15820	COG1902	pentaerythritol trinitrate reductase activity
DDW44_RS15870	COG1051	belongs to the nudix hydrolase family
DDW44_RS15880	COG1796	DNA polymerase
DDW44_RS15880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DDW44_RS15900	COG0693	protein deglycase activity
DDW44_RS15905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDW44_RS15910	COG1802	Transcriptional regulator
DDW44_RS15955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DDW44_RS15960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DDW44_RS15980	COG1595	DNA-templated transcription, initiation
DDW44_RS16105	COG2188	Transcriptional regulator
DDW44_RS16115	COG2188	Transcriptional regulator
DDW44_RS16205	COG1674	ftsk spoiiie
DDW44_RS16255	COG1408	metallophosphoesterase
DDW44_RS16260	COG1051	belongs to the nudix hydrolase family
DDW44_RS16270	COG1610	YqeY-like protein
DDW44_RS16275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DDW44_RS16290	COG0003	Pfam Anion-transporting ATPase
DDW44_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DDW44_RS16350	COG2267	carboxylic ester hydrolase activity
DDW44_RS16360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DDW44_RS16365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DDW44_RS16430	COG1205	dead DEAH box helicase
DDW44_RS16430	COG1111	helicase
DDW44_RS16435	COG1366	Belongs to the anti-sigma-factor antagonist family
DDW44_RS16440	COG2172	sigma factor antagonist activity
DDW44_RS16445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DDW44_RS16455	COG2890	protein-(glutamine-N5) methyltransferase activity
DDW44_RS16465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DDW44_RS16465	COG1754	DNA topoisomerase type I activity
DDW44_RS16470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DDW44_RS16475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DDW44_RS16540	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS16550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DDW44_RS16550	COG0519	Catalyzes the synthesis of GMP from XMP
DDW44_RS16555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DDW44_RS16560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DDW44_RS16565	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDW44_RS16585	COG0745	RESPONSE REGULATOR receiver
DDW44_RS16655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DDW44_RS16655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DDW44_RS16660	COG0110	maltose O-acetyltransferase activity
DDW44_RS16670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDW44_RS16675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DDW44_RS16680	COG0254	rRNA binding
DDW44_RS16690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DDW44_RS16710	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS16720	COG0076	glutamate decarboxylase activity
DDW44_RS16730	COG0393	Putative heavy-metal-binding
DDW44_RS16735	COG0586	Pfam SNARE associated Golgi protein
DDW44_RS16745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DDW44_RS16765	COG0037	tRNA processing
DDW44_RS16780	COG0302	gtp cyclohydrolase
DDW44_RS16790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DDW44_RS16795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DDW44_RS16810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DDW44_RS16810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DDW44_RS16820	COG1125	glycine betaine transport
DDW44_RS16820	COG0517	IMP dehydrogenase activity
DDW44_RS16825	COG1174	glycine betaine transport
DDW44_RS16830	COG1174	glycine betaine transport
DDW44_RS16845	COG0649	NAD binding
DDW44_RS16865	COG2197	response regulator
DDW44_RS16890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DDW44_RS16895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DDW44_RS16905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DDW44_RS16925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DDW44_RS16950	COG2027	D-alanyl-D-alanine carboxypeptidase
DDW44_RS16960	COG0739	heme binding
DDW44_RS16965	COG2205	protein histidine kinase activity
DDW44_RS16970	COG0745	RESPONSE REGULATOR receiver
DDW44_RS16980	COG1595	DNA-templated transcription, initiation
DDW44_RS16985	COG1194	a g-specific adenine glycosylase
DDW44_RS16995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DDW44_RS17015	COG0248	Ppx GppA phosphatase
DDW44_RS17020	COG1082	Xylose isomerase domain protein TIM barrel
DDW44_RS17030	COG0129	dihydroxy-acid dehydratase activity
DDW44_RS17050	COG1252	NADH dehydrogenase
DDW44_RS17055	COG0842	Transport permease protein
DDW44_RS17055	COG1129	ABC transporter
DDW44_RS17065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DDW44_RS17070	COG1335	isochorismatase
DDW44_RS17080	COG0180	Tryptophanyl-tRNA synthetase
DDW44_RS17110	COG2223	nitrite transmembrane transporter activity
DDW44_RS17115	COG0123	including yeast histone deacetylase and acetoin utilization protein
DDW44_RS17165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DDW44_RS17170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DDW44_RS17175	COG0181	hydroxymethylbilane synthase activity
DDW44_RS17180	COG1648	precorrin-2 dehydrogenase activity
DDW44_RS17180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DDW44_RS17185	COG0113	porphobilinogen synthase activity
DDW44_RS17195	COG0018	arginyl-trna synthetase
DDW44_RS17200	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DDW44_RS17220	COG1690	Belongs to the RtcB family
DDW44_RS17230	COG3842	ATPase activity
DDW44_RS17235	COG1178	ABC-type Fe3 transport system permease component
DDW44_RS17240	COG1840	ABC-type Fe3 transport system, periplasmic component
DDW44_RS17245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDW44_RS17255	COG1742	UPF0060 membrane protein
DDW44_RS17260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDW44_RS17290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DDW44_RS17295	COG0406	alpha-ribazole phosphatase activity
DDW44_RS17305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DDW44_RS17310	COG0785	Cytochrome C biogenesis protein
DDW44_RS17315	COG1333	cytochrome c biogenesis protein
DDW44_RS17320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DDW44_RS17340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DDW44_RS17345	COG0109	protoheme IX farnesyltransferase activity
DDW44_RS17360	COG0163	prenyltransferase activity
DDW44_RS17370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDW44_RS17385	COG1301	dicarboxylic acid transport
DDW44_RS17395	COG1309	transcriptional regulator
DDW44_RS17405	COG1278	Cold shock
DDW44_RS17410	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DDW44_RS17415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DDW44_RS17425	COG2226	methyltransferase
DDW44_RS17430	COG2066	Belongs to the glutaminase family
DDW44_RS17455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS17460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS17465	COG0649	NAD binding
DDW44_RS17475	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DDW44_RS17480	COG1034	ATP synthesis coupled electron transport
DDW44_RS17485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DDW44_RS17490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS17500	COG0713	ATP synthesis coupled electron transport
DDW44_RS17505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DDW44_RS17515	COG1007	ATP synthesis coupled electron transport
DDW44_RS17535	COG0142	geranyltranstransferase activity
DDW44_RS17555	COG2234	aminopeptidase activity
DDW44_RS17555	COG4935	Belongs to the peptidase S8 family
DDW44_RS17570	COG1013	pyruvate-flavodoxin oxidoreductase activity
DDW44_RS17575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DDW44_RS17575	COG0674	pyruvate-flavodoxin oxidoreductase activity
DDW44_RS17585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS17590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS17600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DDW44_RS17605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS17610	COG0839	Belongs to the complex I subunit 6 family
DDW44_RS17615	COG0713	ATP synthesis coupled electron transport
DDW44_RS17630	COG1007	ATP synthesis coupled electron transport
DDW44_RS17640	COG0501	Belongs to the peptidase M48B family
DDW44_RS17645	COG3304	Inner membrane component domain
DDW44_RS17655	COG2261	transglycosylase associated protein
DDW44_RS17670	COG1666	GTP binding
DDW44_RS17740	COG0305	Participates in initiation and elongation during chromosome replication
DDW44_RS17815	COG0483	inositol monophosphate 1-phosphatase activity
DDW44_RS17825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DDW44_RS17835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDW44_RS17840	COG5280	Phage tail tape measure protein TP901
DDW44_RS17840	COG3953	SLT domain
DDW44_RS17845	COG0702	epimerase
DDW44_RS17865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DDW44_RS17870	COG2030	dehydratase
DDW44_RS17880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DDW44_RS17885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDW44_RS17890	COG0436	Aminotransferase
DDW44_RS17900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DDW44_RS17915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DDW44_RS17920	COG0081	regulation of translation
DDW44_RS17935	COG0222	ribosome binding
DDW44_RS17945	COG0085	RNA polymerase activity
DDW44_RS17950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DDW44_RS17960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DDW44_RS17965	COG0049	tRNA binding
DDW44_RS17970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DDW44_RS17990	COG0051	transcription antitermination factor activity, RNA binding
DDW44_RS17995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DDW44_RS18000	COG0088	Forms part of the polypeptide exit tunnel
DDW44_RS18005	COG0089	rRNA binding
DDW44_RS18010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DDW44_RS18015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DDW44_RS18020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DDW44_RS18025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DDW44_RS18030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DDW44_RS18035	COG0255	Belongs to the universal ribosomal protein uL29 family
DDW44_RS18040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DDW44_RS18045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DDW44_RS18050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DDW44_RS18055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DDW44_RS18060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDW44_RS18070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DDW44_RS18075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DDW44_RS18080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DDW44_RS18085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DDW44_RS18090	COG1841	ribosomal large subunit assembly
DDW44_RS18095	COG0200	Binds to the 23S rRNA
DDW44_RS18105	COG0563	adenylate kinase activity
DDW44_RS18115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DDW44_RS18120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DDW44_RS18125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DDW44_RS18130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DDW44_RS18135	COG0202	RNA polymerase activity
DDW44_RS18140	COG0203	ribosomal protein L17
DDW44_RS18145	COG0101	tRNA pseudouridine synthase activity
DDW44_RS18155	COG0488	(ABC) transporter
DDW44_RS18160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DDW44_RS18165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DDW44_RS18170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DDW44_RS18200	COG1072	(Pantothenic acid kinase))
DDW44_RS18210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DDW44_RS18215	COG0736	holo-[acyl-carrier-protein] synthase activity
DDW44_RS18225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DDW44_RS18235	COG0802	atpase or kinase
DDW44_RS18260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DDW44_RS18275	COG0726	polysaccharide deacetylase
DDW44_RS18280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DDW44_RS18285	COG0459	protein refolding
DDW44_RS18295	COG4221	oxidoreductase activity
DDW44_RS18300	COG2258	MOSC domain
DDW44_RS18305	COG0583	DNA-binding transcription factor activity
DDW44_RS18315	COG2197	response regulator
DDW44_RS18320	COG1595	DNA-templated transcription, initiation
DDW44_RS18330	COG0516	GMP reductase activity
DDW44_RS18355	COG0515	serine threonine protein kinase
DDW44_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS18380	COG0519	Catalyzes the synthesis of GMP from XMP
DDW44_RS18380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DDW44_RS18420	COG2197	response regulator
DDW44_RS18445	COG0739	heme binding
DDW44_RS18450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DDW44_RS18455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDW44_RS18480	COG0714	Associated with various cellular activities
DDW44_RS18490	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DDW44_RS18505	COG0045	succinate-CoA ligase (ADP-forming) activity
DDW44_RS18535	COG0138	bifunctional purine biosynthesis protein purh
DDW44_RS18545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DDW44_RS18565	COG0039	L-malate dehydrogenase activity
DDW44_RS18570	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS18580	COG0517	IMP dehydrogenase activity
DDW44_RS18580	COG4175	Glycine betaine
DDW44_RS18585	COG4176	ABC-type proline glycine betaine transport system permease component
DDW44_RS18595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDW44_RS18600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DDW44_RS18615	COG0754	glutathionylspermidine amidase activity
DDW44_RS18620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDW44_RS18625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDW44_RS18630	COG0180	Tryptophanyl-tRNA synthetase
DDW44_RS18670	COG1686	Belongs to the peptidase S11 family
DDW44_RS18675	COG1408	metallophosphoesterase
DDW44_RS18680	COG0747	negative chemotaxis
DDW44_RS18685	COG1309	transcriptional regulator
DDW44_RS18705	COG2755	lipolytic protein G-D-S-L family
DDW44_RS18740	COG2009	succinate dehydrogenase
DDW44_RS18750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DDW44_RS18780	COG1595	DNA-templated transcription, initiation
DDW44_RS18795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDW44_RS18795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDW44_RS18830	COG1216	Glycosyl transferase, family 2
DDW44_RS18840	COG1083	cytidylyl-transferase
DDW44_RS18845	COG2089	acid synthase
DDW44_RS18855	COG1473	amidohydrolase
DDW44_RS18855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DDW44_RS18860	COG1744	ABC transporter substrate-binding protein PnrA-like
DDW44_RS18865	COG3845	ABC transporter
DDW44_RS18875	COG1079	Belongs to the binding-protein-dependent transport system permease family
DDW44_RS18910	COG2814	Major facilitator Superfamily
DDW44_RS18915	COG0583	DNA-binding transcription factor activity
DDW44_RS18925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDW44_RS18950	COG2205	protein histidine kinase activity
DDW44_RS18955	COG0745	RESPONSE REGULATOR receiver
DDW44_RS18960	COG1595	DNA-templated transcription, initiation
DDW44_RS18980	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS18985	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS19005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DDW44_RS19035	COG4770	biotin carboxylase activity
DDW44_RS19045	COG0424	maF-like protein
DDW44_RS19055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDW44_RS19070	COG1024	Enoyl-CoA hydratase
DDW44_RS19080	COG2986	histidine ammonia-lyase
DDW44_RS19095	COG0745	RESPONSE REGULATOR receiver
DDW44_RS19100	COG2205	protein histidine kinase activity
DDW44_RS19115	COG1376	ErfK ybiS ycfS ynhG family protein
DDW44_RS19125	COG1064	alcohol dehydrogenase
DDW44_RS19130	COG2197	response regulator
DDW44_RS19135	COG4585	Histidine kinase
DDW44_RS19150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDW44_RS19180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DDW44_RS19195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DDW44_RS19205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DDW44_RS19220	COG1331	Highly conserved protein containing a thioredoxin domain
DDW44_RS19270	COG0463	Glycosyl transferase, family 2
DDW44_RS19280	COG1846	Transcriptional regulator
DDW44_RS19295	COG1331	Highly conserved protein containing a thioredoxin domain
DDW44_RS19310	COG0463	Glycosyl transferase, family 2
DDW44_RS19330	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DDW44_RS19410	COG1396	sequence-specific DNA binding
DDW44_RS19415	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
DDW44_RS19450	COG2894	cell division
DDW44_RS19490	COG2197	response regulator
DDW44_RS19510	COG2885	chlorophyll binding
DDW44_RS19530	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DDW44_RS19545	COG0667	Aldo Keto reductase
DDW44_RS19550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DDW44_RS19555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DDW44_RS19570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDW44_RS19575	COG0450	alkyl hydroperoxide reductase
DDW44_RS19615	COG0114	fumarate hydratase activity
DDW44_RS19620	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DDW44_RS19620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DDW44_RS19645	COG0778	Nitroreductase
DDW44_RS19650	COG1722	exodeoxyribonuclease VII activity
DDW44_RS19655	COG1570	exodeoxyribonuclease VII activity
DDW44_RS19660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DDW44_RS19675	COG0012	GTP binding
DDW44_RS19720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDW44_RS19725	COG2226	methyltransferase
DDW44_RS19730	COG0398	Pfam SNARE associated Golgi protein
DDW44_RS19735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DDW44_RS19740	COG4134	Bacterial extracellular solute-binding protein
DDW44_RS19750	COG1177	transmembrane transport
DDW44_RS19765	COG1595	DNA-templated transcription, initiation
DDW44_RS19820	COG1053	succinate dehydrogenase
DDW44_RS19840	COG1217	gtp-binding protein TYPA
DDW44_RS19845	COG4166	transmembrane transport
DDW44_RS19850	COG0601	transmembrane transport
DDW44_RS19855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDW44_RS19860	COG0444	Belongs to the ABC transporter superfamily
DDW44_RS19865	COG4608	Belongs to the ABC transporter superfamily
DDW44_RS19875	COG0601	transmembrane transport
DDW44_RS19880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDW44_RS19885	COG0444	Belongs to the ABC transporter superfamily
DDW44_RS19890	COG4608	Belongs to the ABC transporter superfamily
DDW44_RS19920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DDW44_RS19970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDW44_RS19975	COG1611	Belongs to the LOG family
DDW44_RS19980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DDW44_RS19990	COG0519	Catalyzes the synthesis of GMP from XMP
DDW44_RS19995	COG1024	Enoyl-CoA hydratase
DDW44_RS20010	COG1595	DNA-templated transcription, initiation
DDW44_RS20020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DDW44_RS20025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DDW44_RS20055	COG0598	Magnesium transport protein CorA
DDW44_RS20075	COG0613	PHP domain protein
DDW44_RS20080	COG2095	MarC family integral membrane protein
DDW44_RS20085	COG1432	Conserved Protein
DDW44_RS20095	COG0513	Belongs to the DEAD box helicase family
DDW44_RS20115	COG2826	transposase and inactivated derivatives, IS30 family
DDW44_RS20135	COG0596	Alpha beta hydrolase
DDW44_RS20135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDW44_RS20195	COG0210	DNA helicase
DDW44_RS20200	COG0210	DNA helicase
DDW44_RS20245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DDW44_RS20295	COG3480	Lon protease (S16) C-terminal proteolytic domain
DDW44_RS20305	COG1615	UPF0182 protein
DDW44_RS20350	COG0753	catalase activity
DDW44_RS20360	COG0483	inositol monophosphate 1-phosphatase activity
DDW44_RS20380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DDW44_RS20390	COG2135	peptidase activity
DDW44_RS20400	COG1595	DNA-templated transcription, initiation
DDW44_RS20405	COG5662	AntiSigma factor
DDW44_RS20410	COG2199	diguanylate cyclase activity
DDW44_RS20410	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DDW44_RS20425	COG0242	peptide deformylase activity
DDW44_RS20455	COG1966	Carbon starvation protein
DDW44_RS20460	COG2188	Transcriptional regulator
DDW44_RS20465	COG2182	Extracellular solute-binding protein
DDW44_RS20470	COG1175	transmembrane transport
DDW44_RS20475	COG0395	ABC-type sugar transport system, permease component
DDW44_RS20480	COG1472	Belongs to the glycosyl hydrolase 3 family
DDW44_RS20485	COG0363	glucosamine-6-phosphate deaminase activity
DDW44_RS20500	COG1597	lipid kinase activity
DDW44_RS20545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDW44_RS20550	COG0142	geranyltranstransferase activity
DDW44_RS20590	COG0583	DNA-binding transcription factor activity
DDW44_RS20615	COG4106	trans-aconitate 2-methyltransferase activity
DDW44_RS20620	COG1126	abc transporter atp-binding protein
DDW44_RS20630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDW44_RS20640	COG0604	alcohol dehydrogenase
DDW44_RS20685	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDW44_RS20685	COG0567	Dehydrogenase, E1 component
DDW44_RS20690	COG2205	protein histidine kinase activity
DDW44_RS20695	COG0745	RESPONSE REGULATOR receiver
DDW44_RS20710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DDW44_RS20720	COG3227	Zinc metalloprotease (Elastase)
DDW44_RS20790	COG0768	penicillin binding
DDW44_RS20795	COG0772	Belongs to the SEDS family
DDW44_RS20800	COG2205	protein histidine kinase activity
DDW44_RS20820	COG1793	dna ligase
DDW44_RS20825	COG3285	dna ligase
DDW44_RS20825	COG1793	dna ligase
DDW44_RS20830	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DDW44_RS20840	COG1175	transmembrane transport
DDW44_RS20880	COG4948	Mandelate Racemase Muconate Lactonizing
DDW44_RS20885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDW44_RS20945	COG0018	arginyl-trna synthetase
DDW44_RS20945	COG0018	arginyl-trna synthetase
DDW44_RS20950	COG0019	diaminopimelate decarboxylase activity
DDW44_RS20955	COG0460	homoserine dehydrogenase
DDW44_RS20960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DDW44_RS20965	COG0083	homoserine kinase activity
DDW44_RS20980	COG1316	TRANSCRIPTIONal
DDW44_RS20985	COG0254	rRNA binding
DDW44_RS20990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DDW44_RS20995	COG2890	protein-(glutamine-N5) methyltransferase activity
DDW44_RS21005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DDW44_RS21035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDW44_RS21040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DDW44_RS21045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDW44_RS21050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DDW44_RS21055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DDW44_RS21060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DDW44_RS21065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DDW44_RS21085	COG2197	response regulator
DDW44_RS21090	COG4585	Histidine kinase
DDW44_RS21105	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDW44_RS21120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DDW44_RS21175	COG0183	Belongs to the thiolase family
DDW44_RS21190	COG0745	RESPONSE REGULATOR receiver
DDW44_RS21195	COG2205	protein histidine kinase activity
DDW44_RS21240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDW44_RS21240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDW44_RS21280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DDW44_RS21285	COG0280	phosphate acetyltransferase
DDW44_RS21285	COG0857	belongs to the CobB CobQ family
DDW44_RS21290	COG0205	6-phosphofructokinase activity
DDW44_RS21305	COG4565	transcriptional regulatory protein
DDW44_RS21310	COG3290	protein histidine kinase activity
DDW44_RS21315	COG1301	dicarboxylic acid transport
DDW44_RS21340	COG3973	AAA domain
DDW44_RS21345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DDW44_RS21360	COG0366	Alpha amylase catalytic
DDW44_RS21365	COG0058	SHG alpha-glucan phosphorylase activity
DDW44_RS21390	COG1132	(ABC) transporter
DDW44_RS21395	COG1132	(ABC) transporter
DDW44_RS21405	COG1376	ErfK ybiS ycfS ynhG family protein
DDW44_RS21440	COG1760	l-serine dehydratase
DDW44_RS21445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DDW44_RS21450	COG0509	glycine decarboxylation via glycine cleavage system
DDW44_RS21455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DDW44_RS21475	COG4166	transmembrane transport
DDW44_RS21480	COG0601	transmembrane transport
DDW44_RS21485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDW44_RS21490	COG0444	Belongs to the ABC transporter superfamily
DDW44_RS21495	COG4608	Belongs to the ABC transporter superfamily
DDW44_RS21500	COG2860	membrane
DDW44_RS21535	COG0482	sulfurtransferase activity
DDW44_RS21550	COG4221	oxidoreductase activity
DDW44_RS21560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DDW44_RS21570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DDW44_RS21575	COG0154	amidase activity
DDW44_RS21585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DDW44_RS21600	COG2409	Drug exporters of the RND superfamily
DDW44_RS21610	COG2133	pyrroloquinoline quinone binding
DDW44_RS21615	COG0667	Aldo Keto reductase
DDW44_RS21635	COG0440	acetolactate synthase activity
DDW44_RS21640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DDW44_RS21645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDW44_RS21670	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DDW44_RS21685	COG2226	methyltransferase
DDW44_RS21700	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DDW44_RS21705	COG1141	Ferredoxin
DDW44_RS21715	COG2368	4-hydroxyphenylacetate
DDW44_RS21720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DDW44_RS21740	COG0076	glutamate decarboxylase activity
DDW44_RS21745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DDW44_RS21755	COG1131	(ABC) transporter
DDW44_RS21760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DDW44_RS21795	COG2192	nodulation
DDW44_RS21805	COG3835	regulator
DDW44_RS21810	COG0506	proline dehydrogenase activity
DDW44_RS21815	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS21830	COG0473	3-isopropylmalate dehydrogenase activity
DDW44_RS21835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DDW44_RS21845	COG0831	urea catabolic process
DDW44_RS21845	COG0832	Belongs to the urease beta subunit family
DDW44_RS21850	COG0804	urea catabolic process
DDW44_RS21855	COG2957	Belongs to the agmatine deiminase family
DDW44_RS21870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDW44_RS21895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DDW44_RS21915	COG2018	Roadblock/LC7 domain
DDW44_RS21935	COG2018	Roadblock/LC7 domain
DDW44_RS21940	COG5002	protein histidine kinase activity
DDW44_RS21945	COG0179	Fumarylacetoacetate (FAA) hydrolase
DDW44_RS21950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDW44_RS21995	COG1414	Transcriptional regulator
DDW44_RS22000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DDW44_RS22005	COG0066	3-isopropylmalate dehydratase activity
DDW44_RS22015	COG0776	regulation of translation
DDW44_RS22025	COG1920	GTP binding
DDW44_RS22035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DDW44_RS22040	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDW44_RS22060	COG0351	phosphomethylpyrimidine kinase
DDW44_RS22065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DDW44_RS22070	COG1461	Dihydroxyacetone kinase
DDW44_RS22080	COG0742	ribosomal rna small subunit methyltransferase
DDW44_RS22085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DDW44_RS22100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DDW44_RS22105	COG0571	ribonuclease III activity
DDW44_RS22110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDW44_RS22115	COG2340	Cysteine-rich secretory protein family
DDW44_RS22120	COG1254	Belongs to the acylphosphatase family
DDW44_RS22135	COG0477	Major facilitator Superfamily
DDW44_RS22165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DDW44_RS22175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DDW44_RS22190	COG0228	four-way junction DNA binding
DDW44_RS22195	COG1837	Belongs to the UPF0109 family
DDW44_RS22200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DDW44_RS22205	COG0336	Belongs to the RNA methyltransferase TrmD family
DDW44_RS22210	COG0335	large ribosomal subunit rRNA binding
DDW44_RS22215	COG0681	Belongs to the peptidase S26 family
DDW44_RS22225	COG0681	Belongs to the peptidase S26 family
DDW44_RS22230	COG0681	Belongs to the peptidase S26 family
DDW44_RS22245	COG0792	nuclease activity
DDW44_RS22260	COG1191	sigma factor activity
DDW44_RS22275	COG0052	Belongs to the universal ribosomal protein uS2 family
DDW44_RS22280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DDW44_RS22285	COG0528	UMP kinase activity
DDW44_RS22290	COG0233	cytoplasmic translational termination
DDW44_RS22315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DDW44_RS22330	COG3842	ATPase activity
DDW44_RS22340	COG1136	(ABC) transporter
DDW44_RS22345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DDW44_RS22355	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS22370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDW44_RS22385	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS22390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DDW44_RS22395	COG3842	ATPase activity
DDW44_RS22400	COG1176	ABC-type spermidine putrescine transport system, permease component I
DDW44_RS22405	COG1177	transmembrane transport
DDW44_RS22410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDW44_RS22570	COG1196	nuclear chromosome segregation
DDW44_RS22570	COG0739	heme binding
DDW44_RS22570	COG0741	lytic transglycosylase activity
DDW44_RS22680	COG2508	Transcriptional regulator
DDW44_RS22685	COG0697	spore germination
DDW44_RS22690	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS22695	COG2814	Major facilitator Superfamily
DDW44_RS22710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DDW44_RS22715	COG0750	zinc metalloprotease
DDW44_RS22720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DDW44_RS22730	COG0456	acetyltransferase
DDW44_RS22735	COG0442	prolyl-tRNA aminoacylation
DDW44_RS22755	COG0779	Required for maturation of 30S ribosomal subunits
DDW44_RS22770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DDW44_RS22780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DDW44_RS22785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DDW44_RS22810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDW44_RS22815	COG0601	transmembrane transport
DDW44_RS22820	COG0747	negative chemotaxis
DDW44_RS22845	COG3266	domain, Protein
DDW44_RS22850	COG1404	Belongs to the peptidase S8 family
DDW44_RS22865	COG1404	Belongs to the peptidase S8 family
DDW44_RS22905	COG1674	ftsk spoiiie
DDW44_RS22915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DDW44_RS22920	COG1185	polyribonucleotide nucleotidyltransferase activity
DDW44_RS22925	COG0612	Peptidase, M16
DDW44_RS22930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DDW44_RS22950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DDW44_RS22955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DDW44_RS22960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DDW44_RS22975	COG2208	phosphoserine phosphatase activity
DDW44_RS22975	COG2770	Histidine kinase
DDW44_RS22980	COG2205	protein histidine kinase activity
DDW44_RS22980	COG3437	response regulator, receiver
DDW44_RS22980	COG4999	Histidine kinase
DDW44_RS22980	COG3850	Histidine kinase
DDW44_RS22990	COG1674	ftsk spoiiie
DDW44_RS23000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDW44_RS23010	COG1546	Belongs to the CinA family
DDW44_RS23010	COG1058	Belongs to the CinA family
DDW44_RS23015	COG1396	sequence-specific DNA binding
DDW44_RS23020	COG0783	Belongs to the Dps family
DDW44_RS23030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDW44_RS23035	COG1201	RNA secondary structure unwinding
DDW44_RS23040	COG1917	Cupin 2, conserved barrel domain protein
DDW44_RS23040	COG2207	Transcriptional regulator
DDW44_RS23065	COG0628	permease
DDW44_RS23085	COG1686	Belongs to the peptidase S11 family
DDW44_RS23110	COG0768	penicillin binding
DDW44_RS23120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDW44_RS23125	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS23135	COG0768	penicillin binding
DDW44_RS23140	COG2755	lipolytic protein G-D-S-L family
DDW44_RS23150	COG0765	amino acid transport
DDW44_RS23155	COG0765	amino acid transport
DDW44_RS23160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DDW44_RS23165	COG1126	abc transporter atp-binding protein
DDW44_RS23170	COG0745	RESPONSE REGULATOR receiver
DDW44_RS23175	COG2205	protein histidine kinase activity
DDW44_RS23180	COG2358	TRAP transporter, solute receptor (TAXI family
DDW44_RS23185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDW44_RS23205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DDW44_RS23215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DDW44_RS23235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DDW44_RS23270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DDW44_RS23275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DDW44_RS23280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DDW44_RS23310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DDW44_RS23340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DDW44_RS23345	COG1802	Transcriptional regulator
DDW44_RS23350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DDW44_RS23365	COG0187	DNA topoisomerase II activity
DDW44_RS23375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDW44_RS23380	COG3290	protein histidine kinase activity
DDW44_RS23390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDW44_RS23395	COG0612	Peptidase, M16
DDW44_RS23405	COG0741	lytic transglycosylase activity
DDW44_RS23405	COG1196	nuclear chromosome segregation
DDW44_RS23405	COG0739	heme binding
DDW44_RS23410	COG1802	Transcriptional regulator
DDW44_RS23415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DDW44_RS23440	COG1435	thymidine kinase activity
DDW44_RS23525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DDW44_RS23535	COG1435	thymidine kinase activity
DDW44_RS23580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DDW44_RS23590	COG0745	RESPONSE REGULATOR receiver
DDW44_RS23595	COG2205	protein histidine kinase activity
DDW44_RS23620	COG0756	dUTP diphosphatase activity
DDW44_RS23655	COG0569	domain protein
DDW44_RS23660	COG0531	amino acid
DDW44_RS23665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DDW44_RS23675	COG3654	unkown
DDW44_RS23690	COG1013	pyruvate-flavodoxin oxidoreductase activity
DDW44_RS23695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DDW44_RS23695	COG0674	pyruvate-flavodoxin oxidoreductase activity
DDW44_RS23730	COG2188	Transcriptional regulator
DDW44_RS23765	COG3209	COG3209 Rhs family protein
DDW44_RS23765	COG4104	PAAR repeat-containing protein
DDW44_RS23800	COG1191	sigma factor activity
DDW44_RS23810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DDW44_RS23815	COG0601	transmembrane transport
DDW44_RS23835	COG0019	diaminopimelate decarboxylase activity
DDW44_RS23840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDW44_RS23875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DDW44_RS23910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDW44_RS23960	COG0640	Transcriptional regulator
DDW44_RS23995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDW44_RS24020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDW44_RS24040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DDW44_RS24045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDW44_RS24050	COG2080	2 iron, 2 sulfur cluster binding
DDW44_RS24065	COG1366	Belongs to the anti-sigma-factor antagonist family
DDW44_RS24065	COG2208	phosphoserine phosphatase activity
DDW44_RS24065	COG2172	sigma factor antagonist activity
DDW44_RS24070	COG1799	cell septum assembly
DDW44_RS24095	COG2040	homocysteine
DDW44_RS24100	COG2890	protein-(glutamine-N5) methyltransferase activity
DDW44_RS24105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DDW44_RS24110	COG2235	arginine
DDW44_RS24115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DDW44_RS24125	COG1024	Enoyl-CoA hydratase
DDW44_RS24160	COG0006	proline dipeptidase activity
DDW44_RS24195	COG3938	Belongs to the proline racemase family
DDW44_RS24220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DDW44_RS24230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DDW44_RS24255	COG3903	Transcriptional regulator
DDW44_RS24255	COG3629	intracellular signal transduction
DDW44_RS24260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DDW44_RS24305	COG0604	alcohol dehydrogenase
DDW44_RS24305	COG3321	synthase
DDW44_RS24305	COG0604	alcohol dehydrogenase
DDW44_RS24305	COG3321	synthase
DDW44_RS24320	COG1733	regulation of RNA biosynthetic process
DDW44_RS24335	COG0702	epimerase
DDW44_RS24375	COG1653	transport
DDW44_RS24380	COG1175	transmembrane transport
DDW44_RS24385	COG0395	ABC-type sugar transport system, permease component
DDW44_RS24390	COG1940	carbohydrate kinase activity
DDW44_RS24395	COG4213	ABC transporter substrate-binding protein
DDW44_RS24405	COG4214	carbohydrate transport
DDW44_RS24410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DDW44_RS24415	COG0531	amino acid
DDW44_RS24430	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDW44_RS24430	COG1024	Enoyl-CoA hydratase
DDW44_RS24435	COG0183	Belongs to the thiolase family
DDW44_RS24440	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DDW44_RS24455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DDW44_RS24460	COG0446	pyridine nucleotide-disulphide oxidoreductase
DDW44_RS24470	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DDW44_RS24475	COG3253	May function as heme-dependent peroxidase
DDW44_RS24490	COG3220	belongs to the UPF0276 family
DDW44_RS24510	COG2326	polyphosphate kinase activity
DDW44_RS24540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DDW44_RS24545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DDW44_RS24575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DDW44_RS24585	COG0789	Transcriptional regulator
DDW44_RS24610	COG0346	lactoylglutathione lyase activity
DDW44_RS24620	COG0300	oxidoreductase activity
DDW44_RS24670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DDW44_RS24675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DDW44_RS24685	COG1554	hydrolase, family 65, central catalytic
DDW44_RS24745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DDW44_RS24750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DDW44_RS24770	COG0529	Catalyzes the synthesis of activated sulfate
DDW44_RS24775	COG0175	sulfate reduction
DDW44_RS24805	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS24830	COG5002	protein histidine kinase activity
DDW44_RS24845	COG2124	cytochrome p450
DDW44_RS24850	COG3424	synthase
DDW44_RS24855	COG2124	cytochrome p450
DDW44_RS24875	COG1162	GTPase activity
DDW44_RS24890	COG0028	Belongs to the TPP enzyme family
DDW44_RS24910	COG1802	Transcriptional regulator
DDW44_RS24940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDW44_RS24945	COG2252	PERMEase
DDW44_RS24955	COG1716	ATPase activity
DDW44_RS24955	COG1131	(ABC) transporter
DDW44_RS24955	COG0842	Transport permease protein
DDW44_RS24995	COG0697	spore germination
DDW44_RS25030	COG1595	DNA-templated transcription, initiation
DDW44_RS25040	COG2124	cytochrome p450
DDW44_RS25050	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS25060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DDW44_RS25065	COG2072	flavoprotein involved in K transport
DDW44_RS25075	COG0640	Transcriptional regulator
DDW44_RS25080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DDW44_RS25085	COG0659	secondary active sulfate transmembrane transporter activity
DDW44_RS25105	COG0252	asparaginase activity
DDW44_RS25140	COG0702	epimerase
DDW44_RS25155	COG3046	protein related to deoxyribodipyrimidine photolyase
DDW44_RS25165	COG0142	geranyltranstransferase activity
DDW44_RS25185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDW44_RS25185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DDW44_RS25190	COG4106	trans-aconitate 2-methyltransferase activity
DDW44_RS25215	COG4251	negative regulation of phosphorylation
DDW44_RS25220	COG0784	Response regulator, receiver
DDW44_RS25245	COG2826	transposase and inactivated derivatives, IS30 family
DDW44_RS25255	COG1191	sigma factor activity
DDW44_RS25270	COG2409	Drug exporters of the RND superfamily
DDW44_RS25275	COG1846	Transcriptional regulator
DDW44_RS25305	COG1959	2 iron, 2 sulfur cluster binding
DDW44_RS25305	COG1295	ribonuclease BN
DDW44_RS25345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DDW44_RS25350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DDW44_RS25355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DDW44_RS25365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDW44_RS25370	COG1309	transcriptional regulator
DDW44_RS25420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDW44_RS25425	COG1120	ATPase activity
DDW44_RS25435	COG2814	Major facilitator Superfamily
DDW44_RS25440	COG0367	asparagine synthase
DDW44_RS25475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DDW44_RS25485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DDW44_RS25505	COG2130	NADP-dependent
DDW44_RS25510	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS25515	COG3835	regulator
DDW44_RS25535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDW44_RS25545	COG2508	Transcriptional regulator
DDW44_RS25555	COG0411	ABC transporter
DDW44_RS25590	COG0598	Magnesium transport protein CorA
DDW44_RS25595	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS25610	COG3960	tartronate-semialdehyde synthase activity
DDW44_RS25625	COG0640	Transcriptional regulator
DDW44_RS25635	COG2268	Band 7 protein
DDW44_RS25645	COG1316	TRANSCRIPTIONal
DDW44_RS25665	COG0753	catalase activity
DDW44_RS25670	COG2084	Dehydrogenase
DDW44_RS25675	COG3622	Belongs to the hyi family
DDW44_RS25695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DDW44_RS25725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DDW44_RS25765	COG2351	hydroxyisourate hydrolase activity
DDW44_RS25780	COG2233	PERMEase
DDW44_RS25810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DDW44_RS25820	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DDW44_RS25885	COG0438	transferase activity, transferring glycosyl groups
DDW44_RS25915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DDW44_RS25925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DDW44_RS25930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DDW44_RS25955	COG1414	Transcriptional regulator
DDW44_RS25960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDW44_RS25965	COG4266	Belongs to the allantoicase family
DDW44_RS25985	COG0277	FAD linked oxidase domain protein
DDW44_RS25990	COG1597	lipid kinase activity
DDW44_RS26005	COG0673	inositol 2-dehydrogenase activity
DDW44_RS26010	COG2188	Transcriptional regulator
DDW44_RS26020	COG1879	ABC-type sugar transport system periplasmic component
DDW44_RS26030	COG1129	ABC transporter
DDW44_RS26075	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS26080	COG1271	oxidase subunit
DDW44_RS26095	COG3387	PFAM Glycoside hydrolase 15-related
DDW44_RS26105	COG1940	carbohydrate kinase activity
DDW44_RS26115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DDW44_RS26145	COG2124	cytochrome p450
DDW44_RS26155	COG0405	Gamma-glutamyltransferase
DDW44_RS26205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DDW44_RS26210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDW44_RS26215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DDW44_RS26220	COG1953	Uracil, thiamine, allantoin
DDW44_RS26225	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS26240	COG0483	inositol monophosphate 1-phosphatase activity
DDW44_RS26255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DDW44_RS26280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DDW44_RS26295	COG1929	Belongs to the glycerate kinase type-1 family
DDW44_RS26325	COG0688	phosphatidylethanolamine metabolic process
DDW44_RS26330	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS26345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDW44_RS26345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DDW44_RS26350	COG0604	alcohol dehydrogenase
DDW44_RS26360	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDW44_RS26415	COG2362	D-Aminopeptidase
DDW44_RS26420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DDW44_RS26425	COG1506	peptidase
DDW44_RS26425	COG0823	Involved in the tonB-independent uptake of proteins
DDW44_RS26425	COG4946	Tricorn protease homolog
DDW44_RS26430	COG1619	proteins homologs of microcin C7 resistance protein MccF
DDW44_RS26435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DDW44_RS26490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DDW44_RS26505	COG0531	amino acid
DDW44_RS26525	COG2154	pterin-4-alpha-carbinolamine dehydratase
DDW44_RS26530	COG4106	trans-aconitate 2-methyltransferase activity
DDW44_RS26535	COG2855	membrane
DDW44_RS26545	COG0583	DNA-binding transcription factor activity
DDW44_RS26550	COG0656	L-ascorbic acid biosynthetic process
DDW44_RS26560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DDW44_RS26565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDW44_RS26630	COG0395	ABC-type sugar transport system, permease component
DDW44_RS26650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DDW44_RS26695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DDW44_RS26700	COG1115	amino acid carrier protein
DDW44_RS26720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DDW44_RS26725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DDW44_RS26730	COG2080	2 iron, 2 sulfur cluster binding
DDW44_RS26795	COG0628	permease
DDW44_RS26800	COG1959	2 iron, 2 sulfur cluster binding
DDW44_RS26895	COG2340	Cysteine-rich secretory protein family
DDW44_RS26900	COG0494	nUDIX hydrolase
DDW44_RS26935	COG1486	melibiose metabolic process
DDW44_RS26950	COG3012	SEC-C Motif Domain Protein
DDW44_RS26955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DDW44_RS26965	COG1309	transcriptional regulator
DDW44_RS26980	COG1793	dna ligase
DDW44_RS27020	COG1834	amidinotransferase
DDW44_RS27025	COG0488	(ABC) transporter
DDW44_RS27050	COG1515	deoxyribonuclease V activity
DDW44_RS27055	COG3268	Saccharopine dehydrogenase
DDW44_RS27065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DDW44_RS27075	COG0183	Belongs to the thiolase family
DDW44_RS27080	COG1024	Enoyl-CoA hydratase
DDW44_RS27080	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDW44_RS27135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DDW44_RS27140	COG0488	(ABC) transporter
DDW44_RS27145	COG2183	response to ionizing radiation
DDW44_RS27165	COG1024	Enoyl-CoA hydratase
DDW44_RS27180	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DDW44_RS27215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DDW44_RS27235	COG1388	LysM domain
DDW44_RS27235	COG1134	teichoic acid transport
DDW44_RS27240	COG1562	ergosterol biosynthetic process
DDW44_RS27250	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DDW44_RS27260	COG1657	PFAM Prenyltransferase squalene oxidase
DDW44_RS27285	COG2365	Tyrosine phosphatase family
DDW44_RS27295	COG2755	lipolytic protein G-D-S-L family
DDW44_RS27305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DDW44_RS27335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDW44_RS27345	COG2318	DinB family
DDW44_RS27355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DDW44_RS27370	COG1007	ATP synthesis coupled electron transport
DDW44_RS27375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS27395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DDW44_RS27405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DDW44_RS27435	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS27465	COG3958	Transketolase
DDW44_RS27470	COG3959	Transketolase, thiamine diphosphate binding domain
DDW44_RS27530	COG0017	Asparaginyl-tRNA synthetase
DDW44_RS27535	COG0069	glutamate synthase activity
DDW44_RS27545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDW44_RS27550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDW44_RS27570	COG2175	clavaminate synthase activity
DDW44_RS27590	COG3629	intracellular signal transduction
DDW44_RS27590	COG3903	Transcriptional regulator
DDW44_RS27600	COG0477	Major facilitator Superfamily
DDW44_RS27615	COG1404	Belongs to the peptidase S8 family
DDW44_RS27645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DDW44_RS27670	COG2205	protein histidine kinase activity
DDW44_RS27670	COG0784	Response regulator, receiver
DDW44_RS27685	COG0517	IMP dehydrogenase activity
DDW44_RS27695	COG1191	sigma factor activity
DDW44_RS27710	COG1295	ribonuclease BN
DDW44_RS27725	COG2318	DinB family
DDW44_RS27730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DDW44_RS27735	COG0386	Belongs to the glutathione peroxidase family
DDW44_RS27770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DDW44_RS27775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDW44_RS27780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DDW44_RS27805	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DDW44_RS27835	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DDW44_RS27915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DDW44_RS27925	COG0667	Aldo Keto reductase
DDW44_RS27955	COG1121	(ABC) transporter
DDW44_RS27960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DDW44_RS27970	COG0803	Belongs to the bacterial solute-binding protein 9 family
DDW44_RS27980	COG3634	alkyl hydroperoxide reductase activity
DDW44_RS27990	COG0254	rRNA binding
DDW44_RS27995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DDW44_RS28000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDW44_RS28005	COG0523	cobalamin synthesis protein
DDW44_RS28030	COG0515	serine threonine protein kinase
DDW44_RS28030	COG2815	serine threonine protein kinase
DDW44_RS28125	COG2124	cytochrome p450
DDW44_RS28135	COG3973	AAA domain
DDW44_RS28165	COG0604	alcohol dehydrogenase
DDW44_RS28165	COG3321	synthase
DDW44_RS28245	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DDW44_RS28260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DDW44_RS28265	COG1652	LysM domain
DDW44_RS28310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDW44_RS28345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DDW44_RS28350	COG3275	phosphorelay sensor kinase activity
DDW44_RS28365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DDW44_RS28365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DDW44_RS28415	COG0583	DNA-binding transcription factor activity
DDW44_RS28425	COG1053	succinate dehydrogenase
DDW44_RS28430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DDW44_RS28435	COG1024	Enoyl-CoA hydratase
DDW44_RS28460	COG3360	Dodecin
DDW44_RS28475	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DDW44_RS28480	COG0121	glutamine amidotransferase
DDW44_RS28485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DDW44_RS28490	COG3572	ergothioneine biosynthetic process
DDW44_RS28505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DDW44_RS28510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDW44_RS28565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DDW44_RS28570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDW44_RS28575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DDW44_RS28580	COG1120	ATPase activity
DDW44_RS28585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DDW44_RS28740	COG2770	Histidine kinase
DDW44_RS28740	COG2208	phosphoserine phosphatase activity
DDW44_RS28770	COG5002	protein histidine kinase activity
DDW44_RS28770	COG2205	protein histidine kinase activity
DDW44_RS28770	COG0784	Response regulator, receiver
DDW44_RS28795	COG0723	plastoquinol--plastocyanin reductase activity
DDW44_RS28795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DDW44_RS28805	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DDW44_RS28870	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS28890	COG0668	transmembrane transport
DDW44_RS28930	COG0477	Major facilitator Superfamily
DDW44_RS28935	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DDW44_RS28970	COG1597	lipid kinase activity
DDW44_RS28995	COG1174	glycine betaine transport
DDW44_RS29000	COG1174	glycine betaine transport
DDW44_RS29010	COG0517	IMP dehydrogenase activity
DDW44_RS29010	COG1125	glycine betaine transport
DDW44_RS29025	COG2271	Major facilitator Superfamily
DDW44_RS29040	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS29045	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS29080	COG0647	UMP catabolic process
DDW44_RS29110	COG0009	L-threonylcarbamoyladenylate synthase
DDW44_RS29115	COG4214	carbohydrate transport
DDW44_RS29125	COG4213	ABC transporter substrate-binding protein
DDW44_RS29145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DDW44_RS29150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DDW44_RS29155	COG2326	polyphosphate kinase activity
DDW44_RS29210	COG0596	Alpha beta hydrolase
DDW44_RS29215	COG0019	diaminopimelate decarboxylase activity
DDW44_RS29230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDW44_RS29235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDW44_RS29245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DDW44_RS29250	COG1120	ATPase activity
DDW44_RS29265	COG1012	belongs to the aldehyde dehydrogenase family
DDW44_RS29320	COG2018	Roadblock/LC7 domain
DDW44_RS29330	COG1957	nucleoside hydrolase
DDW44_RS29340	COG1357	PFAM Pentapeptide repeats (8 copies)
DDW44_RS29360	COG1793	dna ligase
DDW44_RS29360	COG3285	dna ligase
DDW44_RS29365	COG3959	Transketolase, thiamine diphosphate binding domain
DDW44_RS29370	COG1252	NADH dehydrogenase
DDW44_RS29385	COG2018	Roadblock/LC7 domain
DDW44_RS29395	COG1793	dna ligase
DDW44_RS29410	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DDW44_RS29410	COG3608	succinylglutamate desuccinylase aspartoacylase
DDW44_RS29560	COG2770	Histidine kinase
DDW44_RS29560	COG2208	phosphoserine phosphatase activity
DDW44_RS29570	COG1819	glycosyl
DDW44_RS29575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DDW44_RS29640	COG1063	alcohol dehydrogenase
DDW44_RS29645	COG0156	8-amino-7-oxononanoate synthase activity
DDW44_RS29660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DDW44_RS29670	COG1024	Enoyl-CoA hydratase
DDW44_RS29670	COG1250	3-hydroxyacyl-CoA dehydrogenase
DDW44_RS29685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DDW44_RS29750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DDW44_RS29785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DDW44_RS29795	COG4935	Belongs to the peptidase S8 family
DDW44_RS29795	COG2234	aminopeptidase activity
DDW44_RS29810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDW44_RS29825	COG4651	solute:proton antiporter activity
DDW44_RS29825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DDW44_RS29840	COG0204	Acyl-transferase
DDW44_RS29860	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DDW44_RS29870	COG2197	response regulator
DDW44_RS29875	COG4585	Histidine kinase
DDW44_RS29885	COG2132	Multicopper oxidase
DDW44_RS29930	COG0445	tRNA wobble uridine modification
DDW44_RS29955	COG2223	nitrite transmembrane transporter activity
DDW44_RS29960	COG1940	carbohydrate kinase activity
DDW44_RS29980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DDW44_RS29995	COG1349	DNA-binding transcription factor activity
DDW44_RS30005	COG0464	growth
DDW44_RS30025	COG1215	transferase activity, transferring glycosyl groups
DDW44_RS30030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DDW44_RS30050	COG1051	belongs to the nudix hydrolase family
DDW44_RS30055	COG1028	Short-chain dehydrogenase reductase Sdr
DDW44_RS30085	COG3842	ATPase activity
DDW44_RS30090	COG3842	ATPase activity
DDW44_RS30095	COG0395	ABC-type sugar transport system, permease component
DDW44_RS30115	COG3284	Transcriptional regulator
DDW44_RS30170	COG2890	protein-(glutamine-N5) methyltransferase activity
DDW44_RS30185	COG1556	Lactate utilization protein
DDW44_RS30190	COG1139	Iron-sulfur cluster binding protein
DDW44_RS30195	COG0247	lactate metabolic process
DDW44_RS30210	COG2197	response regulator
DDW44_RS30240	COG0659	secondary active sulfate transmembrane transporter activity
DDW44_RS30290	COG1129	ABC transporter
DDW44_RS30295	COG1879	ABC-type sugar transport system periplasmic component
DDW44_RS30300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DDW44_RS30305	COG1869	D-ribose catabolic process
DDW44_RS30530	COG0154	amidase activity
DDW44_RS30700	COG1475	DNA binding
DDW44_RS30845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DDW44_RS30955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DDW44_RS30985	COG2124	cytochrome p450
DDW44_RS30990	COG2124	cytochrome p450
DDW44_RS31040	COG4941	Belongs to the sigma-70 factor family
DDW44_RS31050	COG0477	Major facilitator Superfamily
DDW44_RS31075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DDW44_RS31105	COG0367	asparagine synthase
DDW44_RS31115	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS31120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DDW44_RS31135	COG0318	PFAM AMP-dependent synthetase and ligase
DDW44_RS31140	COG0028	Belongs to the TPP enzyme family
DDW44_RS31165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DDW44_RS31170	COG1045	serine acetyltransferase
DDW44_RS31180	COG1181	Belongs to the D-alanine--D-alanine ligase family
DDW44_RS31225	COG0477	Major facilitator Superfamily
DDW44_RS31250	COG0477	Major facilitator Superfamily
DDW44_RS31270	COG0596	Alpha beta hydrolase
DDW44_RS31285	COG1309	transcriptional regulator
DDW44_RS31290	COG1902	pentaerythritol trinitrate reductase activity
DDW44_RS31305	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DDW44_RS31310	COG0512	Glutamine amidotransferase of anthranilate synthase
DDW44_RS31330	COG2124	cytochrome p450
DDW44_RS31340	COG2409	Drug exporters of the RND superfamily
DDW44_RS31355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DDW44_RS31370	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS31385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DDW44_RS31395	COG1960	acyl-CoA dehydrogenase activity
DDW44_RS31455	COG2124	cytochrome p450
DDW44_RS31540	COG1475	DNA binding