locus-tag	class	description
JEK78_RS00050	COG0134	indole-3-glycerol-phosphate synthase activity
JEK78_RS00060	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS00065	COG0662	Cupin 2, conserved barrel domain protein
JEK78_RS00070	COG0159	tryptophan synthase activity
JEK78_RS00075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JEK78_RS00085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS00090	COG2030	dehydratase
JEK78_RS00100	COG0156	8-amino-7-oxononanoate synthase activity
JEK78_RS00105	COG3629	intracellular signal transduction
JEK78_RS00115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JEK78_RS00125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JEK78_RS00190	COG2801	Transposase and inactivated derivatives
JEK78_RS00245	COG2409	Drug exporters of the RND superfamily
JEK78_RS00285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JEK78_RS00290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JEK78_RS00300	COG1013	pyruvate-flavodoxin oxidoreductase activity
JEK78_RS00305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JEK78_RS00305	COG0674	pyruvate-flavodoxin oxidoreductase activity
JEK78_RS00400	COG2826	transposase and inactivated derivatives, IS30 family
JEK78_RS00445	COG0604	alcohol dehydrogenase
JEK78_RS00445	COG3321	synthase
JEK78_RS00495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JEK78_RS00510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JEK78_RS00535	COG3321	synthase
JEK78_RS00535	COG0604	alcohol dehydrogenase
JEK78_RS00585	COG1794	racemase activity, acting on amino acids and derivatives
JEK78_RS00605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JEK78_RS00615	COG3547	Transposase (IS116 IS110 IS902 family)
JEK78_RS00620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JEK78_RS00640	COG0318	PFAM AMP-dependent synthetase and ligase
JEK78_RS00645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JEK78_RS00645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JEK78_RS00650	COG0105	UTP biosynthetic process
JEK78_RS00670	COG4555	ABC transporter
JEK78_RS00695	COG3547	Transposase (IS116 IS110 IS902 family)
JEK78_RS00710	COG3629	intracellular signal transduction
JEK78_RS00715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JEK78_RS00725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JEK78_RS00735	COG0667	Aldo Keto reductase
JEK78_RS00755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JEK78_RS00780	COG0477	Major facilitator Superfamily
JEK78_RS00800	COG2234	aminopeptidase activity
JEK78_RS00800	COG4935	Belongs to the peptidase S8 family
JEK78_RS00805	COG0596	Alpha beta hydrolase
JEK78_RS00840	COG0542	response to heat
JEK78_RS00845	COG0076	glutamate decarboxylase activity
JEK78_RS00850	COG0697	spore germination
JEK78_RS00860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JEK78_RS00865	COG0589	response to stress
JEK78_RS00885	COG2372	response to copper ion
JEK78_RS00885	COG1276	copper resistance
JEK78_RS00945	COG0589	response to stress
JEK78_RS00970	COG0583	DNA-binding transcription factor activity
JEK78_RS00975	COG5640	endopeptidase activity
JEK78_RS00990	COG1073	alpha beta
JEK78_RS01015	COG0009	L-threonylcarbamoyladenylate synthase
JEK78_RS01045	COG0366	Alpha amylase catalytic
JEK78_RS01055	COG3281	Trehalose synthase
JEK78_RS01060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JEK78_RS01115	COG0667	Aldo Keto reductase
JEK78_RS01120	COG0328	RNA-DNA hybrid ribonuclease activity
JEK78_RS01130	COG0640	Transcriptional regulator
JEK78_RS01140	COG0740	serine-type endopeptidase activity
JEK78_RS01145	COG0740	serine-type endopeptidase activity
JEK78_RS01150	COG1396	sequence-specific DNA binding
JEK78_RS01155	COG1191	sigma factor activity
JEK78_RS01170	COG0842	Transport permease protein
JEK78_RS01170	COG1716	ATPase activity
JEK78_RS01170	COG1131	(ABC) transporter
JEK78_RS01175	COG0667	Aldo Keto reductase
JEK78_RS01180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JEK78_RS01185	COG0346	lactoylglutathione lyase activity
JEK78_RS01240	COG1024	Enoyl-CoA hydratase
JEK78_RS01260	COG2070	2-Nitropropane dioxygenase
JEK78_RS01265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JEK78_RS01275	COG0028	Belongs to the TPP enzyme family
JEK78_RS01285	COG2814	Major facilitator Superfamily
JEK78_RS01300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JEK78_RS01315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JEK78_RS01320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JEK78_RS01330	COG2423	ornithine cyclodeaminase activity
JEK78_RS01345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JEK78_RS01355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS01360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JEK78_RS01370	COG1131	(ABC) transporter
JEK78_RS01380	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS01385	COG2376	Dihydroxyacetone kinase
JEK78_RS01390	COG1461	Dihydroxyacetone kinase
JEK78_RS01395	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JEK78_RS01405	COG1902	pentaerythritol trinitrate reductase activity
JEK78_RS01405	COG0446	pyridine nucleotide-disulphide oxidoreductase
JEK78_RS01420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JEK78_RS01425	COG1017	nitric oxide dioxygenase activity
JEK78_RS01425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JEK78_RS01430	COG2066	Belongs to the glutaminase family
JEK78_RS01440	COG2186	Transcriptional regulator
JEK78_RS01445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JEK78_RS01450	COG1993	acr, cog1993
JEK78_RS01455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JEK78_RS01490	COG1733	regulation of RNA biosynthetic process
JEK78_RS01530	COG1215	transferase activity, transferring glycosyl groups
JEK78_RS01550	COG0464	growth
JEK78_RS01560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JEK78_RS01575	COG2814	Major facilitator Superfamily
JEK78_RS01580	COG2813	Specifically methylates the guanine in position
JEK78_RS01605	COG1216	Glycosyl transferase, family 2
JEK78_RS01615	COG2197	response regulator
JEK78_RS01630	COG2124	cytochrome p450
JEK78_RS01690	COG0445	tRNA wobble uridine modification
JEK78_RS01700	COG1660	Displays ATPase and GTPase activities
JEK78_RS01720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JEK78_RS01760	COG0584	glycerophosphoryl diester phosphodiesterase
JEK78_RS01780	COG0671	phosphoesterase, PA-phosphatase related
JEK78_RS01805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JEK78_RS01855	COG2018	Roadblock/LC7 domain
JEK78_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS01915	COG2124	cytochrome p450
JEK78_RS01920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JEK78_RS01925	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS01935	COG0668	transmembrane transport
JEK78_RS01950	COG2329	Antibiotic biosynthesis monooxygenase
JEK78_RS01965	COG2764	glyoxalase bleomycin resistance protein dioxygenase
JEK78_RS01990	COG0183	Belongs to the thiolase family
JEK78_RS01995	COG0783	Belongs to the Dps family
JEK78_RS02020	COG1063	alcohol dehydrogenase
JEK78_RS02030	COG0583	DNA-binding transcription factor activity
JEK78_RS02035	COG0156	8-amino-7-oxononanoate synthase activity
JEK78_RS02040	COG1063	alcohol dehydrogenase
JEK78_RS02075	COG2755	lipolytic protein G-D-S-L family
JEK78_RS02080	COG0739	heme binding
JEK78_RS02085	COG2365	Tyrosine phosphatase family
JEK78_RS02115	COG1657	PFAM Prenyltransferase squalene oxidase
JEK78_RS02125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JEK78_RS02135	COG1562	ergosterol biosynthetic process
JEK78_RS02140	COG1134	teichoic acid transport
JEK78_RS02140	COG1388	LysM domain
JEK78_RS02180	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JEK78_RS02190	COG2183	response to ionizing radiation
JEK78_RS02195	COG1250	3-hydroxyacyl-CoA dehydrogenase
JEK78_RS02195	COG1024	Enoyl-CoA hydratase
JEK78_RS02200	COG0183	Belongs to the thiolase family
JEK78_RS02205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JEK78_RS02210	COG3268	Saccharopine dehydrogenase
JEK78_RS02235	COG1793	dna ligase
JEK78_RS02245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JEK78_RS02290	COG0297	glycogen (starch) synthase activity
JEK78_RS02305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JEK78_RS02325	COG1486	melibiose metabolic process
JEK78_RS02330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JEK78_RS02365	COG0656	L-ascorbic acid biosynthetic process
JEK78_RS02370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JEK78_RS02375	COG2154	pterin-4-alpha-carbinolamine dehydratase
JEK78_RS02390	COG0443	Heat shock 70 kDa protein
JEK78_RS02445	COG0488	(ABC) transporter
JEK78_RS02450	COG1597	lipid kinase activity
JEK78_RS02485	COG0823	Involved in the tonB-independent uptake of proteins
JEK78_RS02485	COG1506	peptidase
JEK78_RS02485	COG4946	Tricorn protease homolog
JEK78_RS02490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JEK78_RS02495	COG2362	D-Aminopeptidase
JEK78_RS02505	COG2208	phosphoserine phosphatase activity
JEK78_RS02505	COG2172	sigma factor antagonist activity
JEK78_RS02505	COG1366	Belongs to the anti-sigma-factor antagonist family
JEK78_RS02515	COG0596	Alpha beta hydrolase
JEK78_RS02520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JEK78_RS02520	COG0456	acetyltransferase
JEK78_RS02530	COG1250	3-hydroxyacyl-CoA dehydrogenase
JEK78_RS02540	COG0604	alcohol dehydrogenase
JEK78_RS02545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JEK78_RS02545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JEK78_RS02550	COG2301	Belongs to the HpcH HpaI aldolase family
JEK78_RS02560	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS02565	COG0688	phosphatidylethanolamine metabolic process
JEK78_RS02575	COG1929	Belongs to the glycerate kinase type-1 family
JEK78_RS02580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JEK78_RS02605	COG0483	inositol monophosphate 1-phosphatase activity
JEK78_RS02620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JEK78_RS02630	COG0542	response to heat
JEK78_RS02640	COG0596	Alpha beta hydrolase
JEK78_RS02675	COG1940	carbohydrate kinase activity
JEK78_RS02695	COG2188	Transcriptional regulator
JEK78_RS02720	COG0523	cobalamin synthesis protein
JEK78_RS02735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JEK78_RS02740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JEK78_RS02745	COG0019	diaminopimelate decarboxylase activity
JEK78_RS02750	COG1846	Transcriptional regulator
JEK78_RS02755	COG2409	Drug exporters of the RND superfamily
JEK78_RS02760	COG0702	epimerase
JEK78_RS02770	COG3046	protein related to deoxyribodipyrimidine photolyase
JEK78_RS02775	COG0142	geranyltranstransferase activity
JEK78_RS02795	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
JEK78_RS02800	COG2226	methyltransferase
JEK78_RS02835	COG4264	IucA IucC family
JEK78_RS02845	COG0406	alpha-ribazole phosphatase activity
JEK78_RS02870	COG2508	Transcriptional regulator
JEK78_RS02870	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JEK78_RS02880	COG1802	Transcriptional regulator
JEK78_RS02905	COG1162	GTPase activity
JEK78_RS02920	COG2040	homocysteine
JEK78_RS02925	COG2318	DinB family
JEK78_RS02955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JEK78_RS02965	COG0175	sulfate reduction
JEK78_RS02970	COG0529	Catalyzes the synthesis of activated sulfate
JEK78_RS02990	COG1116	anion transmembrane transporter activity
JEK78_RS03065	COG1174	glycine betaine transport
JEK78_RS03070	COG1174	glycine betaine transport
JEK78_RS03100	COG5002	protein histidine kinase activity
JEK78_RS03105	COG0745	RESPONSE REGULATOR receiver
JEK78_RS03130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JEK78_RS03135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JEK78_RS03160	COG3253	May function as heme-dependent peroxidase
JEK78_RS03165	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JEK78_RS03170	COG0446	pyridine nucleotide-disulphide oxidoreductase
JEK78_RS03175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JEK78_RS03195	COG0183	Belongs to the thiolase family
JEK78_RS03200	COG1024	Enoyl-CoA hydratase
JEK78_RS03200	COG1250	3-hydroxyacyl-CoA dehydrogenase
JEK78_RS03215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JEK78_RS03220	COG4214	carbohydrate transport
JEK78_RS03230	COG4213	ABC transporter substrate-binding protein
JEK78_RS03235	COG1940	carbohydrate kinase activity
JEK78_RS03255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JEK78_RS03270	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JEK78_RS03280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JEK78_RS03290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JEK78_RS03300	COG2267	carboxylic ester hydrolase activity
JEK78_RS03305	COG3433	isochorismatase activity
JEK78_RS03305	COG1535	isochorismatase
JEK78_RS03310	COG1535	isochorismatase
JEK78_RS03310	COG3433	isochorismatase activity
JEK78_RS03315	COG1021	2,3-dihydroxybenzoate-AMP ligase
JEK78_RS03320	COG1169	isochorismate synthase
JEK78_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS03330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JEK78_RS03335	COG2382	esterase
JEK78_RS03340	COG0477	Major facilitator Superfamily
JEK78_RS03345	COG3251	PFAM MbtH domain protein
JEK78_RS03350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS03360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JEK78_RS03365	COG1120	ATPase activity
JEK78_RS03400	COG2326	polyphosphate kinase activity
JEK78_RS03420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JEK78_RS03425	COG2235	arginine
JEK78_RS03435	COG1799	cell septum assembly
JEK78_RS03450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JEK78_RS03455	COG0310	cobalt ion transport
JEK78_RS03460	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
JEK78_RS03465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JEK78_RS03470	COG1122	ATPase activity
JEK78_RS03480	COG1115	amino acid carrier protein
JEK78_RS03505	COG1695	Transcriptional regulator
JEK78_RS03510	COG0456	acetyltransferase
JEK78_RS03520	COG1959	2 iron, 2 sulfur cluster binding
JEK78_RS03530	COG1120	ATPase activity
JEK78_RS03535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JEK78_RS03545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS03595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JEK78_RS03600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JEK78_RS03605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JEK78_RS03610	COG0254	rRNA binding
JEK78_RS03620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JEK78_RS03625	COG0515	serine threonine protein kinase
JEK78_RS03625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JEK78_RS03690	COG2205	protein histidine kinase activity
JEK78_RS03740	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
JEK78_RS03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JEK78_RS03810	COG0531	amino acid
JEK78_RS03815	COG0569	domain protein
JEK78_RS03840	COG0756	dUTP diphosphatase activity
JEK78_RS03865	COG2205	protein histidine kinase activity
JEK78_RS03870	COG0745	RESPONSE REGULATOR receiver
JEK78_RS03885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JEK78_RS03920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JEK78_RS03925	COG1802	Transcriptional regulator
JEK78_RS03935	COG0612	Peptidase, M16
JEK78_RS03940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JEK78_RS03950	COG0372	Belongs to the citrate synthase family
JEK78_RS03960	COG0187	DNA topoisomerase II activity
JEK78_RS03975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JEK78_RS03980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JEK78_RS03985	COG2186	Transcriptional regulator
JEK78_RS03990	COG3842	ATPase activity
JEK78_RS04010	COG0514	ATP-dependent DNA helicase (RecQ)
JEK78_RS04025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JEK78_RS04030	COG2226	methyltransferase
JEK78_RS04040	COG0588	phosphoglycerate mutase activity
JEK78_RS04055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JEK78_RS04065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JEK78_RS04085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JEK78_RS04095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JEK78_RS04100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JEK78_RS04110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JEK78_RS04130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JEK78_RS04150	COG2205	protein histidine kinase activity
JEK78_RS04155	COG0745	RESPONSE REGULATOR receiver
JEK78_RS04160	COG1126	abc transporter atp-binding protein
JEK78_RS04165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JEK78_RS04170	COG0765	amino acid transport
JEK78_RS04175	COG0765	amino acid transport
JEK78_RS04185	COG2137	regulation of response to DNA damage stimulus
JEK78_RS04190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JEK78_RS04195	COG0628	permease
JEK78_RS04205	COG1201	RNA secondary structure unwinding
JEK78_RS04210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JEK78_RS04245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JEK78_RS04265	COG0783	Belongs to the Dps family
JEK78_RS04270	COG1396	sequence-specific DNA binding
JEK78_RS04275	COG1058	Belongs to the CinA family
JEK78_RS04275	COG1546	Belongs to the CinA family
JEK78_RS04285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JEK78_RS04295	COG1674	ftsk spoiiie
JEK78_RS04305	COG0784	Response regulator, receiver
JEK78_RS04305	COG2205	protein histidine kinase activity
JEK78_RS04310	COG2208	phosphoserine phosphatase activity
JEK78_RS04310	COG2770	Histidine kinase
JEK78_RS04340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JEK78_RS04345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JEK78_RS04350	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
JEK78_RS04370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JEK78_RS04375	COG0612	Peptidase, M16
JEK78_RS04380	COG1185	polyribonucleotide nucleotidyltransferase activity
JEK78_RS04385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JEK78_RS04395	COG0455	bacterial-type flagellum organization
JEK78_RS04405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JEK78_RS04410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JEK78_RS04420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JEK78_RS04435	COG0779	Required for maturation of 30S ribosomal subunits
JEK78_RS04455	COG0442	prolyl-tRNA aminoacylation
JEK78_RS04470	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JEK78_RS04475	COG0750	zinc metalloprotease
JEK78_RS04480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JEK78_RS04490	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS04515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JEK78_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS04555	COG2072	flavoprotein involved in K transport
JEK78_RS04560	COG0798	PFAM Bile acid sodium symporter
JEK78_RS04570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JEK78_RS04575	COG0492	ferredoxin-NADP+ reductase activity
JEK78_RS04580	COG3842	ATPase activity
JEK78_RS04585	COG4149	molybdate abc transporter
JEK78_RS04595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JEK78_RS04600	COG0575	Belongs to the CDS family
JEK78_RS04605	COG0233	cytoplasmic translational termination
JEK78_RS04610	COG0528	UMP kinase activity
JEK78_RS04615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JEK78_RS04620	COG0052	Belongs to the universal ribosomal protein uS2 family
JEK78_RS04635	COG1191	sigma factor activity
JEK78_RS04650	COG0792	nuclease activity
JEK78_RS04660	COG0681	Belongs to the peptidase S26 family
JEK78_RS04670	COG0681	Belongs to the peptidase S26 family
JEK78_RS04675	COG0335	large ribosomal subunit rRNA binding
JEK78_RS04680	COG0336	Belongs to the RNA methyltransferase TrmD family
JEK78_RS04685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JEK78_RS04690	COG1837	Belongs to the UPF0109 family
JEK78_RS04695	COG0228	four-way junction DNA binding
JEK78_RS04710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JEK78_RS04720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JEK78_RS04765	COG1196	nuclear chromosome segregation
JEK78_RS04775	COG1254	Belongs to the acylphosphatase family
JEK78_RS04785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JEK78_RS04790	COG0571	ribonuclease III activity
JEK78_RS04795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JEK78_RS04800	COG1399	metal-binding, possibly nucleic acid-binding protein
JEK78_RS04810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JEK78_RS04815	COG0742	ribosomal rna small subunit methyltransferase
JEK78_RS04825	COG1461	Dihydroxyacetone kinase
JEK78_RS04830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JEK78_RS04835	COG0351	phosphomethylpyrimidine kinase
JEK78_RS04850	COG1181	Belongs to the D-alanine--D-alanine ligase family
JEK78_RS04855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JEK78_RS04865	COG1920	GTP binding
JEK78_RS04875	COG0776	regulation of translation
JEK78_RS04885	COG0066	3-isopropylmalate dehydratase activity
JEK78_RS04890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JEK78_RS04895	COG1414	Transcriptional regulator
JEK78_RS04930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JEK78_RS04935	COG0179	Fumarylacetoacetate (FAA) hydrolase
JEK78_RS04945	COG5002	protein histidine kinase activity
JEK78_RS04950	COG2018	Roadblock/LC7 domain
JEK78_RS04970	COG2018	Roadblock/LC7 domain
JEK78_RS04990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JEK78_RS04995	COG0300	oxidoreductase activity
JEK78_RS05000	COG1032	radical SAM domain protein
JEK78_RS05005	COG0697	spore germination
JEK78_RS05010	COG0438	transferase activity, transferring glycosyl groups
JEK78_RS05015	COG2353	YceI-like domain
JEK78_RS05025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JEK78_RS05030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JEK78_RS05035	COG0473	3-isopropylmalate dehydrogenase activity
JEK78_RS05040	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS05045	COG0506	proline dehydrogenase activity
JEK78_RS05050	COG3835	regulator
JEK78_RS05055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JEK78_RS05060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JEK78_RS05065	COG0440	acetolactate synthase activity
JEK78_RS05075	COG5001	Diguanylate cyclase
JEK78_RS05085	COG0667	Aldo Keto reductase
JEK78_RS05090	COG2133	pyrroloquinoline quinone binding
JEK78_RS05110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JEK78_RS05115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JEK78_RS05125	COG0154	amidase activity
JEK78_RS05130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JEK78_RS05140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JEK78_RS05150	COG4221	oxidoreductase activity
JEK78_RS05155	COG0482	sulfurtransferase activity
JEK78_RS05175	COG2860	membrane
JEK78_RS05180	COG4608	Belongs to the ABC transporter superfamily
JEK78_RS05185	COG0444	Belongs to the ABC transporter superfamily
JEK78_RS05190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JEK78_RS05195	COG0601	transmembrane transport
JEK78_RS05200	COG0747	negative chemotaxis
JEK78_RS05220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JEK78_RS05225	COG0509	glycine decarboxylation via glycine cleavage system
JEK78_RS05230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JEK78_RS05235	COG1760	l-serine dehydratase
JEK78_RS05255	COG1132	(ABC) transporter
JEK78_RS05260	COG1132	(ABC) transporter
JEK78_RS05265	COG1132	(ABC) transporter
JEK78_RS05270	COG1132	(ABC) transporter
JEK78_RS05295	COG3281	Trehalose synthase
JEK78_RS05300	COG1301	dicarboxylic acid transport
JEK78_RS05305	COG3290	protein histidine kinase activity
JEK78_RS05310	COG4565	transcriptional regulatory protein
JEK78_RS05315	COG0205	6-phosphofructokinase activity
JEK78_RS05320	COG0857	belongs to the CobB CobQ family
JEK78_RS05320	COG0280	phosphate acetyltransferase
JEK78_RS05325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JEK78_RS05350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JEK78_RS05350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JEK78_RS05370	COG2124	cytochrome p450
JEK78_RS05380	COG2159	amidohydrolase
JEK78_RS05465	COG0183	Belongs to the thiolase family
JEK78_RS05485	COG1131	(ABC) transporter
JEK78_RS05520	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
JEK78_RS05535	COG1250	3-hydroxyacyl-CoA dehydrogenase
JEK78_RS05555	COG4585	Histidine kinase
JEK78_RS05560	COG2197	response regulator
JEK78_RS05570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JEK78_RS05575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JEK78_RS05580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JEK78_RS05585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JEK78_RS05590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JEK78_RS05595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JEK78_RS05600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JEK78_RS05620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JEK78_RS05625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JEK78_RS05635	COG2890	protein-(glutamine-N5) methyltransferase activity
JEK78_RS05640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JEK78_RS05645	COG0254	rRNA binding
JEK78_RS05650	COG1316	TRANSCRIPTIONal
JEK78_RS05660	COG0083	homoserine kinase activity
JEK78_RS05665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JEK78_RS05670	COG0460	homoserine dehydrogenase
JEK78_RS05675	COG0019	diaminopimelate decarboxylase activity
JEK78_RS05680	COG0018	arginyl-trna synthetase
JEK78_RS05685	COG0745	RESPONSE REGULATOR receiver
JEK78_RS05700	COG3842	ATPase activity
JEK78_RS05750	COG0210	DNA helicase
JEK78_RS05755	COG2815	serine threonine protein kinase
JEK78_RS05755	COG0515	serine threonine protein kinase
JEK78_RS05805	COG3152	Membrane
JEK78_RS05810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JEK78_RS05830	COG1660	Displays ATPase and GTPase activities
JEK78_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS05850	COG2095	MarC family integral membrane protein
JEK78_RS05865	COG0768	penicillin binding
JEK78_RS05870	COG2175	clavaminate synthase activity
JEK78_RS05875	COG0010	Belongs to the arginase family
JEK78_RS05885	COG0367	asparagine synthase
JEK78_RS05910	COG0747	negative chemotaxis
JEK78_RS05915	COG0768	penicillin binding
JEK78_RS05930	COG0747	negative chemotaxis
JEK78_RS05990	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
JEK78_RS06000	COG1793	dna ligase
JEK78_RS06000	COG3285	dna ligase
JEK78_RS06010	COG2205	protein histidine kinase activity
JEK78_RS06025	COG0768	penicillin binding
JEK78_RS06085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JEK78_RS06095	COG0745	RESPONSE REGULATOR receiver
JEK78_RS06100	COG2205	protein histidine kinase activity
JEK78_RS06105	COG0567	Dehydrogenase, E1 component
JEK78_RS06105	COG0508	dehydrogenase complex catalyzes the overall conversion of
JEK78_RS06115	COG0604	alcohol dehydrogenase
JEK78_RS06120	COG0281	malic enzyme
JEK78_RS06125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JEK78_RS06135	COG1126	abc transporter atp-binding protein
JEK78_RS06160	COG0456	acetyltransferase
JEK78_RS06165	COG0142	geranyltranstransferase activity
JEK78_RS06170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JEK78_RS06170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JEK78_RS06205	COG1597	lipid kinase activity
JEK78_RS06220	COG0363	glucosamine-6-phosphate deaminase activity
JEK78_RS06225	COG2188	Transcriptional regulator
JEK78_RS06255	COG2124	cytochrome p450
JEK78_RS06265	COG0242	peptide deformylase activity
JEK78_RS06275	COG5662	AntiSigma factor
JEK78_RS06280	COG1595	DNA-templated transcription, initiation
JEK78_RS06290	COG2135	peptidase activity
JEK78_RS06300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JEK78_RS06305	COG1162	GTPase activity
JEK78_RS06310	COG2076	Multidrug Resistance protein
JEK78_RS06315	COG0483	inositol monophosphate 1-phosphatase activity
JEK78_RS06320	COG0753	catalase activity
JEK78_RS06350	COG1615	UPF0182 protein
JEK78_RS06360	COG3480	Lon protease (S16) C-terminal proteolytic domain
JEK78_RS06395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JEK78_RS06445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JEK78_RS06475	COG2816	NAD+ diphosphatase activity
JEK78_RS06480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JEK78_RS06485	COG0210	DNA helicase
JEK78_RS06570	COG1432	Conserved Protein
JEK78_RS06580	COG2095	MarC family integral membrane protein
JEK78_RS06600	COG0598	Magnesium transport protein CorA
JEK78_RS06635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JEK78_RS06640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JEK78_RS06650	COG1595	DNA-templated transcription, initiation
JEK78_RS06665	COG1024	Enoyl-CoA hydratase
JEK78_RS06670	COG0519	Catalyzes the synthesis of GMP from XMP
JEK78_RS06680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JEK78_RS06690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JEK78_RS06725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JEK78_RS06735	COG4608	Belongs to the ABC transporter superfamily
JEK78_RS06745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JEK78_RS06750	COG0601	transmembrane transport
JEK78_RS06760	COG4608	Belongs to the ABC transporter superfamily
JEK78_RS06775	COG0747	negative chemotaxis
JEK78_RS06780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JEK78_RS06785	COG1217	gtp-binding protein TYPA
JEK78_RS06820	COG1472	Belongs to the glycosyl hydrolase 3 family
JEK78_RS06840	COG2356	endonuclease I
JEK78_RS06855	COG1946	Acyl-CoA thioesterase
JEK78_RS06865	COG1309	transcriptional regulator
JEK78_RS06870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JEK78_RS06880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JEK78_RS06885	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS06905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JEK78_RS06915	COG4977	sequence-specific DNA binding
JEK78_RS06920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JEK78_RS06995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JEK78_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JEK78_RS07010	COG0765	amino acid transport
JEK78_RS07015	COG0765	amino acid transport
JEK78_RS07020	COG1126	abc transporter atp-binding protein
JEK78_RS07075	COG2733	membrane
JEK78_RS07085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JEK78_RS07120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JEK78_RS07130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JEK78_RS07135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JEK78_RS07140	COG1263	PTS System
JEK78_RS07145	COG1234	tRNA 3'-trailer cleavage
JEK78_RS07175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JEK78_RS07185	COG1335	isochorismatase
JEK78_RS07220	COG0277	FAD linked oxidase domain protein
JEK78_RS07225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
JEK78_RS07235	COG1174	glycine betaine transport
JEK78_RS07245	COG1174	glycine betaine transport
JEK78_RS07275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JEK78_RS07295	COG1678	Uncharacterized ACR, COG1678
JEK78_RS07300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JEK78_RS07305	COG0776	regulation of translation
JEK78_RS07315	COG3973	AAA domain
JEK78_RS07340	COG2223	nitrite transmembrane transporter activity
JEK78_RS07375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JEK78_RS07380	COG0793	Belongs to the peptidase S41A family
JEK78_RS07390	COG2884	Cell division ATP-binding protein ftsE
JEK78_RS07405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JEK78_RS07410	COG0515	serine threonine protein kinase
JEK78_RS07415	COG0515	serine threonine protein kinase
JEK78_RS07425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JEK78_RS07430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JEK78_RS07435	COG1764	response to oxidative stress
JEK78_RS07440	COG1846	Transcriptional regulator
JEK78_RS07445	COG1215	transferase activity, transferring glycosyl groups
JEK78_RS07450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JEK78_RS07455	COG1215	transferase activity, transferring glycosyl groups
JEK78_RS07485	COG0653	protein targeting
JEK78_RS07495	COG3214	Protein conserved in bacteria
JEK78_RS07500	COG2197	response regulator
JEK78_RS07505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JEK78_RS07515	COG0823	Involved in the tonB-independent uptake of proteins
JEK78_RS07520	COG5002	protein histidine kinase activity
JEK78_RS07525	COG0745	RESPONSE REGULATOR receiver
JEK78_RS07550	COG0714	Associated with various cellular activities
JEK78_RS07590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JEK78_RS07600	COG1482	cell wall glycoprotein biosynthetic process
JEK78_RS07610	COG2835	tetraacyldisaccharide 4'-kinase activity
JEK78_RS07650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JEK78_RS07655	COG0778	Nitroreductase
JEK78_RS07655	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
JEK78_RS07675	COG1316	TRANSCRIPTIONal
JEK78_RS07685	COG1316	TRANSCRIPTIONal
JEK78_RS07690	COG1316	TRANSCRIPTIONal
JEK78_RS07700	COG1607	acyl-coa hydrolase
JEK78_RS07710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JEK78_RS07735	COG2205	protein histidine kinase activity
JEK78_RS07745	COG3104	oligopeptide transport
JEK78_RS07760	COG1366	Belongs to the anti-sigma-factor antagonist family
JEK78_RS07765	COG1191	sigma factor activity
JEK78_RS07770	COG1228	amidohydrolase
JEK78_RS07775	COG1228	amidohydrolase
JEK78_RS07780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JEK78_RS07785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JEK78_RS07830	COG2755	lipolytic protein G-D-S-L family
JEK78_RS07835	COG0183	Belongs to the thiolase family
JEK78_RS07865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JEK78_RS07870	COG1252	NADH dehydrogenase
JEK78_RS07890	COG0148	phosphopyruvate hydratase activity
JEK78_RS07900	COG1652	LysM domain
JEK78_RS07925	COG4974	Belongs to the 'phage' integrase family
JEK78_RS07990	COG2814	Major facilitator Superfamily
JEK78_RS08020	COG4585	Histidine kinase
JEK78_RS08030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JEK78_RS08035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JEK78_RS08040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JEK78_RS08045	COG0193	aminoacyl-tRNA hydrolase activity
JEK78_RS08050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JEK78_RS08060	COG1309	transcriptional regulator
JEK78_RS08065	COG4106	trans-aconitate 2-methyltransferase activity
JEK78_RS08070	COG1846	Transcriptional regulator
JEK78_RS08075	COG2197	response regulator
JEK78_RS08090	COG0488	(ABC) transporter
JEK78_RS08095	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JEK78_RS08100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JEK78_RS08110	COG0084	hydrolase, TatD family'
JEK78_RS08135	COG1476	TRANSCRIPTIONal
JEK78_RS08155	COG2801	Transposase and inactivated derivatives
JEK78_RS08160	COG3385	transposase activity
JEK78_RS08245	COG2072	flavoprotein involved in K transport
JEK78_RS08250	COG2267	carboxylic ester hydrolase activity
JEK78_RS08265	COG2409	Drug exporters of the RND superfamily
JEK78_RS08275	COG1122	ATPase activity
JEK78_RS08285	COG0310	cobalt ion transport
JEK78_RS08310	COG1515	deoxyribonuclease V activity
JEK78_RS08365	COG3385	transposase activity
JEK78_RS08370	COG2261	transglycosylase associated protein
JEK78_RS08380	COG3304	Inner membrane component domain
JEK78_RS08385	COG0501	Belongs to the peptidase M48B family
JEK78_RS08390	COG1007	ATP synthesis coupled electron transport
JEK78_RS08400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JEK78_RS08405	COG0713	ATP synthesis coupled electron transport
JEK78_RS08410	COG0839	Belongs to the complex I subunit 6 family
JEK78_RS08415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS08420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JEK78_RS08425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS08430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS08435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS08480	COG0674	pyruvate-flavodoxin oxidoreductase activity
JEK78_RS08480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JEK78_RS08485	COG1013	pyruvate-flavodoxin oxidoreductase activity
JEK78_RS08505	COG1228	amidohydrolase
JEK78_RS08525	COG0142	geranyltranstransferase activity
JEK78_RS08535	COG0561	phosphatase activity
JEK78_RS08550	COG0514	ATP-dependent DNA helicase (RecQ)
JEK78_RS08555	COG1007	ATP synthesis coupled electron transport
JEK78_RS08565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JEK78_RS08570	COG0713	ATP synthesis coupled electron transport
JEK78_RS08575	COG0839	Belongs to the complex I subunit 6 family
JEK78_RS08580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS08585	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JEK78_RS08590	COG1034	ATP synthesis coupled electron transport
JEK78_RS08595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JEK78_RS08605	COG0649	NAD binding
JEK78_RS08610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS08615	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS08635	COG2226	methyltransferase
JEK78_RS08645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JEK78_RS08690	COG3385	transposase activity
JEK78_RS08745	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
JEK78_RS08815	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JEK78_RS08820	COG1278	Cold shock
JEK78_RS08825	COG1301	dicarboxylic acid transport
JEK78_RS08840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JEK78_RS08850	COG0163	prenyltransferase activity
JEK78_RS08860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JEK78_RS08865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JEK78_RS08885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JEK78_RS08890	COG1333	cytochrome c biogenesis protein
JEK78_RS08895	COG0785	Cytochrome C biogenesis protein
JEK78_RS08900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JEK78_RS08905	COG0406	alpha-ribazole phosphatase activity
JEK78_RS08910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JEK78_RS08940	COG1289	transmembrane transporter activity
JEK78_RS08945	COG0569	domain protein
JEK78_RS08945	COG0475	glutathione-regulated potassium exporter activity
JEK78_RS08975	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
JEK78_RS08980	COG0018	arginyl-trna synthetase
JEK78_RS08985	COG0113	porphobilinogen synthase activity
JEK78_RS08990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JEK78_RS08990	COG1648	precorrin-2 dehydrogenase activity
JEK78_RS08995	COG0181	hydroxymethylbilane synthase activity
JEK78_RS09000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JEK78_RS09005	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JEK78_RS09050	COG0123	including yeast histone deacetylase and acetoin utilization protein
JEK78_RS09055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JEK78_RS09075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JEK78_RS09080	COG0129	dihydroxy-acid dehydratase activity
JEK78_RS09085	COG1082	Xylose isomerase domain protein TIM barrel
JEK78_RS09090	COG0248	Ppx GppA phosphatase
JEK78_RS09110	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JEK78_RS09120	COG1194	a g-specific adenine glycosylase
JEK78_RS09125	COG1595	DNA-templated transcription, initiation
JEK78_RS09135	COG0745	RESPONSE REGULATOR receiver
JEK78_RS09140	COG2205	protein histidine kinase activity
JEK78_RS09145	COG0739	heme binding
JEK78_RS09160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JEK78_RS09180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JEK78_RS09190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JEK78_RS09195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JEK78_RS09205	COG0640	Transcriptional regulator
JEK78_RS09225	COG0649	NAD binding
JEK78_RS09255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JEK78_RS09270	COG0302	gtp cyclohydrolase
JEK78_RS09285	COG0037	tRNA processing
JEK78_RS09295	COG2027	D-alanyl-D-alanine carboxypeptidase
JEK78_RS09300	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JEK78_RS09310	COG0586	Pfam SNARE associated Golgi protein
JEK78_RS09315	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS09350	COG0477	Major facilitator Superfamily
JEK78_RS09375	COG0494	nUDIX hydrolase
JEK78_RS09410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JEK78_RS09415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JEK78_RS09415	COG1754	DNA topoisomerase type I activity
JEK78_RS09425	COG2264	protein methyltransferase activity
JEK78_RS09440	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JEK78_RS09450	COG1366	Belongs to the anti-sigma-factor antagonist family
JEK78_RS09455	COG1205	dead DEAH box helicase
JEK78_RS09455	COG1111	helicase
JEK78_RS09550	COG0659	secondary active sulfate transmembrane transporter activity
JEK78_RS09555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JEK78_RS09560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JEK78_RS09570	COG2267	carboxylic ester hydrolase activity
JEK78_RS09595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JEK78_RS09620	COG0003	Pfam Anion-transporting ATPase
JEK78_RS09630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JEK78_RS09640	COG1408	metallophosphoesterase
JEK78_RS09705	COG2963	transposase activity
JEK78_RS09720	COG2801	Transposase and inactivated derivatives
JEK78_RS09725	COG1011	Hydrolase
JEK78_RS09745	COG2197	response regulator
JEK78_RS09750	COG4585	Histidine kinase
JEK78_RS09775	COG0542	response to heat
JEK78_RS09800	COG0789	Transcriptional regulator
JEK78_RS09805	COG0484	heat shock protein binding
JEK78_RS09810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JEK78_RS09815	COG0443	Heat shock 70 kDa protein
JEK78_RS09820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JEK78_RS09825	COG0247	lactate metabolic process
JEK78_RS09825	COG2181	nitrate reductase activity
JEK78_RS09835	COG0717	Belongs to the dCTP deaminase family
JEK78_RS09980	COG1131	(ABC) transporter
JEK78_RS09985	COG3559	Exporter of polyketide antibiotics
JEK78_RS09995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JEK78_RS10010	COG1802	Transcriptional regulator
JEK78_RS10020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JEK78_RS10025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JEK78_RS10045	COG1595	DNA-templated transcription, initiation
JEK78_RS10070	COG0701	Predicted permease
JEK78_RS10090	COG0831	urea catabolic process
JEK78_RS10095	COG0832	Belongs to the urease beta subunit family
JEK78_RS10110	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JEK78_RS10115	COG0829	nickel cation binding
JEK78_RS10170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JEK78_RS10175	COG0191	fructose-bisphosphate aldolase activity
JEK78_RS10185	COG3483	tryptophan 2,3-dioxygenase activity
JEK78_RS10190	COG3844	kynureninase activity
JEK78_RS10205	COG0640	Transcriptional regulator
JEK78_RS10220	COG0659	secondary active sulfate transmembrane transporter activity
JEK78_RS10245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JEK78_RS10335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JEK78_RS10340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JEK78_RS10365	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS10370	COG1362	aminopeptidase activity
JEK78_RS10395	COG0508	dehydrogenase complex catalyzes the overall conversion of
JEK78_RS10400	COG0022	dehydrogenase e1 component
JEK78_RS10415	COG0515	serine threonine protein kinase
JEK78_RS10430	COG3321	synthase
JEK78_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS10430	COG0604	alcohol dehydrogenase
JEK78_RS10440	COG0303	'Molybdopterin
JEK78_RS10465	COG1522	sequence-specific DNA binding
JEK78_RS10500	COG3396	Phenylacetate-CoA oxygenase
JEK78_RS10505	COG3460	Phenylacetate-CoA oxygenase
JEK78_RS10510	COG3396	Phenylacetate-CoA oxygenase
JEK78_RS10520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JEK78_RS10610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JEK78_RS10625	COG1716	ATPase activity
JEK78_RS10630	COG1716	ATPase activity
JEK78_RS10645	COG0515	serine threonine protein kinase
JEK78_RS10650	COG3764	Sortase (surface protein transpeptidase)
JEK78_RS10655	COG3764	Sortase (surface protein transpeptidase)
JEK78_RS10670	COG3764	Sortase (surface protein transpeptidase)
JEK78_RS10685	COG0705	Rhomboid family
JEK78_RS10700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JEK78_RS10715	COG0305	Participates in initiation and elongation during chromosome replication
JEK78_RS10725	COG0359	binds to the 23S rRNA
JEK78_RS10730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JEK78_RS10735	COG0629	single-stranded DNA binding
JEK78_RS10740	COG0360	Binds together with S18 to 16S ribosomal RNA
JEK78_RS10765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JEK78_RS10785	COG0617	tRNA 3'-terminal CCA addition
JEK78_RS10800	COG2815	serine threonine protein kinase
JEK78_RS10800	COG0515	serine threonine protein kinase
JEK78_RS10805	COG1595	DNA-templated transcription, initiation
JEK78_RS10815	COG0492	ferredoxin-NADP+ reductase activity
JEK78_RS10820	COG3118	belongs to the thioredoxin family
JEK78_RS10825	COG1475	DNA binding
JEK78_RS10830	COG1192	Involved in chromosome partitioning
JEK78_RS10835	COG0357	Ribosomal RNA small subunit methyltransferase G
JEK78_RS10845	COG0706	membrane insertase activity
JEK78_RS10850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JEK78_RS10855	COG0594	ribonuclease P activity
JEK78_RS10860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JEK78_RS10865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JEK78_RS10870	COG0592	DNA-directed DNA polymerase activity
JEK78_RS10875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JEK78_RS10880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JEK78_RS10885	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JEK78_RS10890	COG0187	DNA topoisomerase II activity
JEK78_RS10895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JEK78_RS10910	COG2188	Transcriptional regulator
JEK78_RS10935	COG0515	serine threonine protein kinase
JEK78_RS10955	COG0626	cystathionine gamma-synthase activity
JEK78_RS10960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JEK78_RS10965	COG1950	PFAM Membrane protein of
JEK78_RS10975	COG0662	Cupin 2, conserved barrel domain protein
JEK78_RS11000	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JEK78_RS11015	COG1609	Transcriptional regulator
JEK78_RS11020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JEK78_RS11025	COG1271	oxidase subunit
JEK78_RS11030	COG1294	oxidase, subunit
JEK78_RS11035	COG4988	ABC transporter
JEK78_RS11045	COG0561	phosphatase activity
JEK78_RS11060	COG0561	phosphatase activity
JEK78_RS11065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JEK78_RS11075	COG2837	iron assimilation
JEK78_RS11090	COG1999	signal sequence binding
JEK78_RS11110	COG0006	proline dipeptidase activity
JEK78_RS11125	COG0653	protein targeting
JEK78_RS11140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JEK78_RS11170	COG1595	DNA-templated transcription, initiation
JEK78_RS11175	COG0318	PFAM AMP-dependent synthetase and ligase
JEK78_RS11180	COG0784	Response regulator, receiver
JEK78_RS11210	COG0745	RESPONSE REGULATOR receiver
JEK78_RS11215	COG2205	protein histidine kinase activity
JEK78_RS11225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JEK78_RS11235	COG1846	Transcriptional regulator
JEK78_RS11245	COG1191	sigma factor activity
JEK78_RS11250	COG1191	sigma factor activity
JEK78_RS11280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JEK78_RS11300	COG0583	DNA-binding transcription factor activity
JEK78_RS11330	COG3634	alkyl hydroperoxide reductase activity
JEK78_RS11350	COG3896	Chloramphenicol phosphotransferase-like protein
JEK78_RS11380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JEK78_RS11390	COG1063	alcohol dehydrogenase
JEK78_RS11410	COG1131	(ABC) transporter
JEK78_RS11425	COG2197	response regulator
JEK78_RS11445	COG0151	Belongs to the GarS family
JEK78_RS11460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JEK78_RS11495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JEK78_RS11500	COG0047	phosphoribosylformylglycinamidine synthase activity
JEK78_RS11505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JEK78_RS11520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JEK78_RS11555	COG1643	Atp-dependent helicase
JEK78_RS11590	COG0513	Belongs to the DEAD box helicase family
JEK78_RS11600	COG1404	Belongs to the peptidase S8 family
JEK78_RS11605	COG2197	response regulator
JEK78_RS11605	COG3903	Transcriptional regulator
JEK78_RS11615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JEK78_RS11615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JEK78_RS11630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JEK78_RS11635	COG1132	(ABC) transporter
JEK78_RS11685	COG4585	Histidine kinase
JEK78_RS11690	COG0579	oxidoreductase
JEK78_RS11720	COG1846	Transcriptional regulator
JEK78_RS11820	COG0739	heme binding
JEK78_RS11820	COG1196	nuclear chromosome segregation
JEK78_RS11820	COG0741	lytic transglycosylase activity
JEK78_RS11825	COG0671	phosphoesterase, PA-phosphatase related
JEK78_RS11845	COG1937	Protein conserved in bacteria
JEK78_RS11855	COG0306	phosphate transporter
JEK78_RS11860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JEK78_RS11865	COG0581	inorganic phosphate transmembrane transporter activity
JEK78_RS11880	COG0494	nUDIX hydrolase
JEK78_RS11880	COG0406	alpha-ribazole phosphatase activity
JEK78_RS11890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JEK78_RS11895	COG0456	acetyltransferase
JEK78_RS11900	COG0737	Belongs to the 5'-nucleotidase family
JEK78_RS11900	COG1525	nuclease
JEK78_RS11900	COG4085	toxin activity
JEK78_RS11910	COG0745	RESPONSE REGULATOR receiver
JEK78_RS11915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JEK78_RS11920	COG1609	Transcriptional regulator
JEK78_RS11925	COG0745	RESPONSE REGULATOR receiver
JEK78_RS11970	COG2897	thiosulfate sulfurtransferase activity
JEK78_RS11990	COG3485	protocatechuate 3,4-dioxygenase
JEK78_RS12000	COG3385	transposase activity
JEK78_RS12020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JEK78_RS12025	COG1490	D-aminoacyl-tRNA deacylase activity
JEK78_RS12035	COG4552	Acetyltransferase involved in intracellular survival and related
JEK78_RS12085	COG0438	transferase activity, transferring glycosyl groups
JEK78_RS12100	COG0588	phosphoglycerate mutase activity
JEK78_RS12105	COG0531	amino acid
JEK78_RS12110	COG0076	glutamate decarboxylase activity
JEK78_RS12130	COG5002	protein histidine kinase activity
JEK78_RS12145	COG1329	Transcriptional regulator
JEK78_RS12150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JEK78_RS12155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JEK78_RS12160	COG0215	cysteine-tRNA ligase activity
JEK78_RS12200	COG3842	ATPase activity
JEK78_RS12275	COG1105	Belongs to the carbohydrate kinase PfkB family
JEK78_RS12280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JEK78_RS12285	COG1940	carbohydrate kinase activity
JEK78_RS12300	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
JEK78_RS12305	COG0463	Glycosyl transferase, family 2
JEK78_RS12320	COG1278	Cold shock
JEK78_RS12325	COG0459	protein refolding
JEK78_RS12335	COG2272	Belongs to the type-B carboxylesterase lipase family
JEK78_RS12350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JEK78_RS12370	COG3973	AAA domain
JEK78_RS12380	COG1061	Type III restriction enzyme res subunit
JEK78_RS12405	COG1278	Cold shock
JEK78_RS12410	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JEK78_RS12415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JEK78_RS12425	COG2814	Major facilitator Superfamily
JEK78_RS12445	COG0024	Methionine aminopeptidase
JEK78_RS12450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JEK78_RS12460	COG2252	PERMEase
JEK78_RS12515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JEK78_RS12520	COG0488	(ABC) transporter
JEK78_RS12525	COG5006	permease, DMT superfamily
JEK78_RS12565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JEK78_RS12590	COG0259	pyridoxamine-phosphate oxidase activity
JEK78_RS12610	COG2945	thiolester hydrolase activity
JEK78_RS12610	COG0596	Alpha beta hydrolase
JEK78_RS12670	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS12675	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS12690	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS12705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JEK78_RS12710	COG1024	Enoyl-CoA hydratase
JEK78_RS12715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JEK78_RS12715	COG1042	CoA-binding domain protein
JEK78_RS12715	COG0045	succinate-CoA ligase (ADP-forming) activity
JEK78_RS12730	COG0259	pyridoxamine-phosphate oxidase activity
JEK78_RS12735	COG0384	phenazine biosynthesis protein PhzF
JEK78_RS12750	COG0077	Prephenate dehydratase
JEK78_RS12755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JEK78_RS12785	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JEK78_RS12790	COG0583	DNA-binding transcription factor activity
JEK78_RS12800	COG1309	transcriptional regulator
JEK78_RS12810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JEK78_RS12810	COG0515	serine threonine protein kinase
JEK78_RS12815	COG1024	Enoyl-CoA hydratase
JEK78_RS12830	COG0318	PFAM AMP-dependent synthetase and ligase
JEK78_RS12870	COG1136	(ABC) transporter
JEK78_RS12895	COG3629	intracellular signal transduction
JEK78_RS12895	COG3903	Transcriptional regulator
JEK78_RS12910	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS12930	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JEK78_RS12935	COG0386	Belongs to the glutathione peroxidase family
JEK78_RS12955	COG1686	Belongs to the peptidase S11 family
JEK78_RS13175	COG3550	peptidyl-serine autophosphorylation
JEK78_RS13210	COG0315	cyclic pyranopterin monophosphate synthase activity
JEK78_RS13210	COG0521	Mo-molybdopterin cofactor biosynthetic process
JEK78_RS13215	COG0315	cyclic pyranopterin monophosphate synthase activity
JEK78_RS13225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JEK78_RS13230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JEK78_RS13240	COG3263	regulation of cellular component size
JEK78_RS13245	COG0477	Major facilitator Superfamily
JEK78_RS13255	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JEK78_RS13300	COG0477	Major facilitator Superfamily
JEK78_RS13345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JEK78_RS13360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JEK78_RS13365	COG1247	-acetyltransferase
JEK78_RS13395	COG0495	leucyl-tRNA aminoacylation
JEK78_RS13400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JEK78_RS13435	COG1181	Belongs to the D-alanine--D-alanine ligase family
JEK78_RS13445	COG1666	GTP binding
JEK78_RS13510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JEK78_RS13525	COG0270	DNA (cytosine-5-)-methyltransferase activity
JEK78_RS13530	COG0702	epimerase
JEK78_RS13550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JEK78_RS13555	COG2030	dehydratase
JEK78_RS13565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JEK78_RS13570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JEK78_RS13575	COG0436	Aminotransferase
JEK78_RS13590	COG0250	Participates in transcription elongation, termination and antitermination
JEK78_RS13595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JEK78_RS13600	COG0081	regulation of translation
JEK78_RS13615	COG0222	ribosome binding
JEK78_RS13620	COG0085	RNA polymerase activity
JEK78_RS13625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JEK78_RS13635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JEK78_RS13640	COG0049	tRNA binding
JEK78_RS13645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JEK78_RS13650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JEK78_RS13660	COG0515	serine threonine protein kinase
JEK78_RS13660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JEK78_RS13670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JEK78_RS13680	COG0583	DNA-binding transcription factor activity
JEK78_RS13685	COG0051	transcription antitermination factor activity, RNA binding
JEK78_RS13690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JEK78_RS13695	COG0088	Forms part of the polypeptide exit tunnel
JEK78_RS13700	COG0089	rRNA binding
JEK78_RS13705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JEK78_RS13710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JEK78_RS13715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JEK78_RS13720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JEK78_RS13725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JEK78_RS13730	COG0255	Belongs to the universal ribosomal protein uL29 family
JEK78_RS13735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JEK78_RS13740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JEK78_RS13745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JEK78_RS13750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JEK78_RS13755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JEK78_RS13760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JEK78_RS13765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JEK78_RS13770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JEK78_RS13775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JEK78_RS13780	COG1841	ribosomal large subunit assembly
JEK78_RS13785	COG0200	Binds to the 23S rRNA
JEK78_RS13790	COG0201	protein transport
JEK78_RS13795	COG0563	adenylate kinase activity
JEK78_RS13805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JEK78_RS13810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JEK78_RS13815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JEK78_RS13820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JEK78_RS13825	COG0202	RNA polymerase activity
JEK78_RS13830	COG0203	ribosomal protein L17
JEK78_RS13840	COG0101	tRNA pseudouridine synthase activity
JEK78_RS13870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JEK78_RS13875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JEK78_RS13880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JEK78_RS13885	COG1072	(Pantothenic acid kinase))
JEK78_RS13890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JEK78_RS13895	COG0736	holo-[acyl-carrier-protein] synthase activity
JEK78_RS13905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JEK78_RS13915	COG0802	atpase or kinase
JEK78_RS13930	COG1214	PFAM Peptidase M22, glycoprotease
JEK78_RS13930	COG0456	acetyltransferase
JEK78_RS13940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JEK78_RS13955	COG0726	polysaccharide deacetylase
JEK78_RS13960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JEK78_RS13965	COG0459	protein refolding
JEK78_RS13975	COG0583	DNA-binding transcription factor activity
JEK78_RS13985	COG2197	response regulator
JEK78_RS13990	COG1595	DNA-templated transcription, initiation
JEK78_RS14000	COG0516	GMP reductase activity
JEK78_RS14020	COG0515	serine threonine protein kinase
JEK78_RS14025	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS14040	COG0519	Catalyzes the synthesis of GMP from XMP
JEK78_RS14040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JEK78_RS14075	COG2197	response regulator
JEK78_RS14095	COG2226	methyltransferase
JEK78_RS14110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JEK78_RS14115	COG0045	succinate-CoA ligase (ADP-forming) activity
JEK78_RS14155	COG0138	bifunctional purine biosynthesis protein purh
JEK78_RS14165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JEK78_RS14180	COG0039	L-malate dehydrogenase activity
JEK78_RS14185	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS14195	COG4175	Glycine betaine
JEK78_RS14195	COG0517	IMP dehydrogenase activity
JEK78_RS14200	COG4176	ABC-type proline glycine betaine transport system permease component
JEK78_RS14210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JEK78_RS14215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JEK78_RS14220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JEK78_RS14225	COG0180	Tryptophanyl-tRNA synthetase
JEK78_RS14255	COG1686	Belongs to the peptidase S11 family
JEK78_RS14260	COG1408	metallophosphoesterase
JEK78_RS14270	COG1053	succinate dehydrogenase
JEK78_RS14280	COG2009	succinate dehydrogenase
JEK78_RS14290	COG3064	Membrane
JEK78_RS14290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JEK78_RS14290	COG3583	domain protein
JEK78_RS14310	COG1309	transcriptional regulator
JEK78_RS14315	COG1595	DNA-templated transcription, initiation
JEK78_RS14335	COG2089	acid synthase
JEK78_RS14345	COG1473	amidohydrolase
JEK78_RS14345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JEK78_RS14350	COG1744	ABC transporter substrate-binding protein PnrA-like
JEK78_RS14355	COG3845	ABC transporter
JEK78_RS14365	COG1079	Belongs to the binding-protein-dependent transport system permease family
JEK78_RS14425	COG2205	protein histidine kinase activity
JEK78_RS14430	COG0745	RESPONSE REGULATOR receiver
JEK78_RS14435	COG1595	DNA-templated transcription, initiation
JEK78_RS14460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JEK78_RS14465	COG0488	(ABC) transporter
JEK78_RS14500	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS14505	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS14520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JEK78_RS14545	COG4770	biotin carboxylase activity
JEK78_RS14550	COG0424	maF-like protein
JEK78_RS14560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JEK78_RS14570	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
JEK78_RS14575	COG1024	Enoyl-CoA hydratase
JEK78_RS14585	COG2986	histidine ammonia-lyase
JEK78_RS14600	COG1376	ErfK ybiS ycfS ynhG family protein
JEK78_RS14605	COG1064	alcohol dehydrogenase
JEK78_RS14615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JEK78_RS14655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JEK78_RS14670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JEK78_RS14680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JEK78_RS14690	COG1331	Highly conserved protein containing a thioredoxin domain
JEK78_RS14695	COG1331	Highly conserved protein containing a thioredoxin domain
JEK78_RS14705	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
JEK78_RS14715	COG0436	Aminotransferase
JEK78_RS14740	COG2894	cell division
JEK78_RS14800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JEK78_RS14805	COG0741	lytic transglycosylase activity
JEK78_RS14815	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JEK78_RS14820	COG0450	alkyl hydroperoxide reductase
JEK78_RS14830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JEK78_RS14845	COG0114	fumarate hydratase activity
JEK78_RS14850	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JEK78_RS14850	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JEK78_RS14875	COG1722	exodeoxyribonuclease VII activity
JEK78_RS14880	COG1570	exodeoxyribonuclease VII activity
JEK78_RS14890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JEK78_RS14905	COG0012	GTP binding
JEK78_RS14925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JEK78_RS14935	COG1051	belongs to the nudix hydrolase family
JEK78_RS14950	COG1674	ftsk spoiiie
JEK78_RS15005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JEK78_RS15010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JEK78_RS15015	COG1120	ATPase activity
JEK78_RS15040	COG1132	(ABC) transporter
JEK78_RS15045	COG1132	(ABC) transporter
JEK78_RS15055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JEK78_RS15060	COG1879	ABC-type sugar transport system periplasmic component
JEK78_RS15065	COG1129	ABC transporter
JEK78_RS15070	COG1609	Transcriptional regulator
JEK78_RS15080	COG1595	DNA-templated transcription, initiation
JEK78_RS15105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JEK78_RS15125	COG1131	(ABC) transporter
JEK78_RS15170	COG2197	response regulator
JEK78_RS15180	COG1131	(ABC) transporter
JEK78_RS15225	COG3409	Peptidoglycan-binding domain 1 protein
JEK78_RS15310	COG0668	transmembrane transport
JEK78_RS15340	COG2259	Doxx family
JEK78_RS15345	COG1695	Transcriptional regulator
JEK78_RS15415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JEK78_RS15455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JEK78_RS15460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JEK78_RS15465	COG1113	amino acid transport
JEK78_RS15475	COG0698	ribose 5-phosphate isomerase
JEK78_RS15490	COG3594	Acyltransferase
JEK78_RS15515	COG0544	peptidyl-prolyl cis-trans isomerase activity
JEK78_RS15520	COG0740	serine-type endopeptidase activity
JEK78_RS15525	COG0740	serine-type endopeptidase activity
JEK78_RS15530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JEK78_RS15535	COG0525	valine-tRNA ligase activity
JEK78_RS15540	COG0285	dihydrofolate synthase activity
JEK78_RS15550	COG0105	UTP biosynthetic process
JEK78_RS15555	COG1077	Cell shape determining protein MreB Mrl
JEK78_RS15580	COG0768	penicillin binding
JEK78_RS15585	COG0772	Belongs to the SEDS family
JEK78_RS15605	COG1530	ribonuclease E activity
JEK78_RS15610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JEK78_RS15615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JEK78_RS15620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JEK78_RS15630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JEK78_RS15640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JEK78_RS15650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JEK78_RS15660	COG0501	Belongs to the peptidase M48B family
JEK78_RS15670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JEK78_RS15680	COG0799	negative regulation of ribosome biogenesis
JEK78_RS15685	COG0406	alpha-ribazole phosphatase activity
JEK78_RS15705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JEK78_RS15715	COG0495	leucyl-tRNA aminoacylation
JEK78_RS15725	COG1307	EDD domain protein, DegV family
JEK78_RS15750	COG0268	Binds directly to 16S ribosomal RNA
JEK78_RS15755	COG0481	GTPase activity
JEK78_RS15760	COG1022	Amp-dependent synthetase and ligase
JEK78_RS15785	COG1420	regulation of RNA biosynthetic process
JEK78_RS15790	COG0484	heat shock protein binding
JEK78_RS15805	COG0537	adenosine 5'-monophosphoramidase activity
JEK78_RS15825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JEK78_RS15895	COG1857	crispr-associated protein
JEK78_RS15910	COG1518	maintenance of DNA repeat elements
JEK78_RS15970	COG0438	transferase activity, transferring glycosyl groups
JEK78_RS16020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JEK78_RS16035	COG2315	Protein conserved in bacteria
JEK78_RS16045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JEK78_RS16065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JEK78_RS16075	COG1381	Involved in DNA repair and RecF pathway recombination
JEK78_RS16080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JEK78_RS16095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JEK78_RS16100	COG1121	(ABC) transporter
JEK78_RS16105	COG0803	Belongs to the bacterial solute-binding protein 9 family
JEK78_RS16105	COG3443	Belongs to the bacterial solute-binding protein 9 family
JEK78_RS16110	COG0423	glycine-tRNA ligase activity
JEK78_RS16120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JEK78_RS16140	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JEK78_RS16145	COG1940	carbohydrate kinase activity
JEK78_RS16150	COG0574	Belongs to the PEP-utilizing enzyme family
JEK78_RS16150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JEK78_RS16175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JEK78_RS16175	COG2146	nitrite reductase [NAD(P)H] activity
JEK78_RS16180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JEK78_RS16185	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JEK78_RS16210	COG0243	molybdopterin cofactor binding
JEK78_RS16215	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JEK78_RS16225	COG0358	DNA primase activity
JEK78_RS16230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JEK78_RS16245	COG1070	Carbohydrate kinase
JEK78_RS16280	COG1077	Cell shape determining protein MreB Mrl
JEK78_RS16285	COG0318	PFAM AMP-dependent synthetase and ligase
JEK78_RS16290	COG1309	transcriptional regulator
JEK78_RS16295	COG0667	Aldo Keto reductase
JEK78_RS16325	COG4981	capsule polysaccharide biosynthetic process
JEK78_RS16390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JEK78_RS16410	COG2130	NADP-dependent
JEK78_RS16430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JEK78_RS16435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JEK78_RS16440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JEK78_RS16470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JEK78_RS16475	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JEK78_RS16520	COG1358	cellular component organization or biogenesis
JEK78_RS16575	COG4122	O-methyltransferase activity
JEK78_RS16585	COG2124	cytochrome p450
JEK78_RS16590	COG0183	Belongs to the thiolase family
JEK78_RS16615	COG3845	ABC transporter
JEK78_RS16645	COG1309	transcriptional regulator
JEK78_RS16650	COG0438	transferase activity, transferring glycosyl groups
JEK78_RS16665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JEK78_RS16690	COG1309	transcriptional regulator
JEK78_RS16700	COG2030	dehydratase
JEK78_RS16710	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS16725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JEK78_RS16740	COG3022	response to hydroperoxide
JEK78_RS16750	COG0789	Transcriptional regulator
JEK78_RS16830	COG1181	Belongs to the D-alanine--D-alanine ligase family
JEK78_RS16845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JEK78_RS16855	COG0174	glutamine synthetase
JEK78_RS16870	COG1181	Belongs to the D-alanine--D-alanine ligase family
JEK78_RS16890	COG1834	amidinotransferase
JEK78_RS16895	COG1132	(ABC) transporter
JEK78_RS16900	COG1132	(ABC) transporter
JEK78_RS16935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS16950	COG3622	Belongs to the hyi family
JEK78_RS16980	COG3385	transposase activity
JEK78_RS16985	COG2801	Transposase and inactivated derivatives
JEK78_RS16990	COG3385	transposase activity
JEK78_RS17005	COG3340	Belongs to the peptidase S51 family
JEK78_RS17040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JEK78_RS17055	COG0017	Asparaginyl-tRNA synthetase
JEK78_RS17175	COG2814	Major facilitator Superfamily
JEK78_RS17230	COG1994	Peptidase M50
JEK78_RS17250	COG0583	DNA-binding transcription factor activity
JEK78_RS17265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JEK78_RS17280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JEK78_RS17280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JEK78_RS17295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JEK78_RS17305	COG0366	Alpha amylase catalytic
JEK78_RS17310	COG0513	Belongs to the DEAD box helicase family
JEK78_RS17315	COG1278	Cold shock
JEK78_RS17350	COG0501	Belongs to the peptidase M48B family
JEK78_RS17360	COG0174	glutamine synthetase
JEK78_RS17380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JEK78_RS17385	COG0321	lipoyl(octanoyl) transferase activity
JEK78_RS17420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JEK78_RS17445	COG0733	neurotransmitter:sodium symporter activity
JEK78_RS17455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JEK78_RS17465	COG0508	dehydrogenase complex catalyzes the overall conversion of
JEK78_RS17470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JEK78_RS17475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JEK78_RS17480	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JEK78_RS17490	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JEK78_RS17510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JEK78_RS17535	COG4585	Histidine kinase
JEK78_RS17560	COG2197	response regulator
JEK78_RS17565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JEK78_RS17570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JEK78_RS17585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JEK78_RS17595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JEK78_RS17600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JEK78_RS17610	COG1376	ErfK ybiS ycfS ynhG family protein
JEK78_RS17620	COG1845	cytochrome c oxidase, subunit III
JEK78_RS17625	COG2010	Cytochrome c
JEK78_RS17630	COG0723	plastoquinol--plastocyanin reductase activity
JEK78_RS17635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JEK78_RS17640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JEK78_RS17645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JEK78_RS17675	COG0791	NLP P60 protein
JEK78_RS17695	COG1022	Amp-dependent synthetase and ligase
JEK78_RS17710	COG0003	Pfam Anion-transporting ATPase
JEK78_RS17720	COG1940	carbohydrate kinase activity
JEK78_RS17765	COG2197	response regulator
JEK78_RS17770	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JEK78_RS17775	COG0243	molybdopterin cofactor binding
JEK78_RS17780	COG2193	ferroxidase activity
JEK78_RS17785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JEK78_RS17790	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JEK78_RS17795	COG2815	serine threonine protein kinase
JEK78_RS17795	COG0515	serine threonine protein kinase
JEK78_RS17800	COG2022	thiamine diphosphate biosynthetic process
JEK78_RS17810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JEK78_RS17810	COG2022	thiamine diphosphate biosynthetic process
JEK78_RS17825	COG0352	thiamine-phosphate diphosphorylase activity
JEK78_RS17850	COG1309	transcriptional regulator
JEK78_RS17860	COG1126	abc transporter atp-binding protein
JEK78_RS17875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JEK78_RS17895	COG0714	Associated with various cellular activities
JEK78_RS17905	COG0275	rRNA processing
JEK78_RS17915	COG0768	penicillin binding
JEK78_RS17920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JEK78_RS17925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JEK78_RS17930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JEK78_RS17935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JEK78_RS17945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JEK78_RS17950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JEK78_RS17955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JEK78_RS17960	COG1496	oxidoreductase activity
JEK78_RS17970	COG1799	cell septum assembly
JEK78_RS17980	COG3599	regulation of cell shape
JEK78_RS17985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JEK78_RS17995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JEK78_RS18035	COG0587	DNA-directed DNA polymerase activity
JEK78_RS18045	COG1432	Conserved Protein
JEK78_RS18080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JEK78_RS18085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JEK78_RS18090	COG0131	Imidazoleglycerol-phosphate dehydratase
JEK78_RS18100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JEK78_RS18105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JEK78_RS18110	COG0107	imidazoleglycerol-phosphate synthase activity
JEK78_RS18120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JEK78_RS18145	COG0134	indole-3-glycerol-phosphate synthase activity
JEK78_RS18155	COG0133	tryptophan synthase activity
JEK78_RS18160	COG0159	tryptophan synthase activity
JEK78_RS18170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JEK78_RS18180	COG0067	glutamate synthase
JEK78_RS18180	COG0069	glutamate synthase activity
JEK78_RS18180	COG0070	glutamate synthase
JEK78_RS18195	COG0287	Prephenate dehydrogenase
JEK78_RS18195	COG1605	Chorismate mutase
JEK78_RS18205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JEK78_RS18240	COG0411	ABC transporter
JEK78_RS18260	COG2050	protein possibly involved in aromatic compounds catabolism
JEK78_RS18290	COG2226	methyltransferase
JEK78_RS18295	COG0539	negative regulation of cytoplasmic translation
JEK78_RS18305	COG0237	dephospho-CoA kinase activity
JEK78_RS18345	COG0584	glycerophosphoryl diester phosphodiesterase
JEK78_RS18350	COG0556	nucleotide-excision repair
JEK78_RS18360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JEK78_RS18375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JEK78_RS18395	COG0322	excinuclease ABC activity
JEK78_RS18400	COG1660	Displays ATPase and GTPase activities
JEK78_RS18405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JEK78_RS18410	COG1481	regulation of sporulation
JEK78_RS18420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JEK78_RS18425	COG0126	phosphoglycerate kinase activity
JEK78_RS18430	COG0149	triose-phosphate isomerase activity
JEK78_RS18435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JEK78_RS18445	COG0166	Belongs to the GPI family
JEK78_RS18455	COG1136	(ABC) transporter
JEK78_RS18455	COG0577	efflux transmembrane transporter activity
JEK78_RS18460	COG1695	Transcriptional regulator
JEK78_RS18465	COG1653	transport
JEK78_RS18470	COG0366	Alpha amylase catalytic
JEK78_RS18480	COG1175	transmembrane transport
JEK78_RS18485	COG0395	ABC-type sugar transport system, permease component
JEK78_RS18490	COG0363	glucosamine-6-phosphate deaminase activity
JEK78_RS18505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JEK78_RS18515	COG0109	protoheme IX farnesyltransferase activity
JEK78_RS18535	COG1131	(ABC) transporter
JEK78_RS18550	COG0719	Fe-S assembly protein
JEK78_RS18560	COG0396	ATPase activity
JEK78_RS18565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JEK78_RS18570	COG0822	iron-sulfur transferase activity
JEK78_RS18580	COG2076	Multidrug Resistance protein
JEK78_RS18585	COG3226	Transcriptional regulator
JEK78_RS18590	COG2171	N-acyltransferase activity
JEK78_RS18600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JEK78_RS18660	COG5285	phytanoyl-CoA dioxygenase
JEK78_RS18665	COG1917	Cupin 2, conserved barrel domain protein
JEK78_RS18670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JEK78_RS18675	COG0456	acetyltransferase
JEK78_RS18720	COG1797	cobyrinic acid a,c-diamide synthase activity
JEK78_RS18740	COG1492	cobalamin metabolic process
JEK78_RS18745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JEK78_RS18760	COG0235	Class ii aldolase
JEK78_RS18775	COG0488	(ABC) transporter
JEK78_RS18785	COG1024	Enoyl-CoA hydratase
JEK78_RS18825	COG2176	DNA-directed DNA polymerase activity
JEK78_RS18845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JEK78_RS18850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JEK78_RS18870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JEK78_RS18875	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS18885	COG2186	Transcriptional regulator
JEK78_RS18890	COG2807	transmembrane transport
JEK78_RS18900	COG0588	phosphoglycerate mutase activity
JEK78_RS18910	COG1716	ATPase activity
JEK78_RS18910	COG0842	Transport permease protein
JEK78_RS18910	COG1131	(ABC) transporter
JEK78_RS18925	COG2197	response regulator
JEK78_RS18940	COG1119	ATPase activity
JEK78_RS18955	COG1881	PFAM PEBP family protein
JEK78_RS18995	COG0647	UMP catabolic process
JEK78_RS19015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JEK78_RS19020	COG0497	DNA recombination
JEK78_RS19030	COG3387	PFAM Glycoside hydrolase 15-related
JEK78_RS19035	COG0504	CTP synthase activity
JEK78_RS19040	COG0494	nUDIX hydrolase
JEK78_RS19065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JEK78_RS19070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JEK78_RS19075	COG1187	pseudouridine synthase activity
JEK78_RS19090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JEK78_RS19100	COG1160	GTP binding
JEK78_RS19120	COG0671	phosphoesterase, PA-phosphatase related
JEK78_RS19130	COG0477	Major facilitator Superfamily
JEK78_RS19135	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS19140	COG1799	cell septum assembly
JEK78_RS19150	COG0587	DNA-directed DNA polymerase activity
JEK78_RS19155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JEK78_RS19160	COG2197	response regulator
JEK78_RS19165	COG4585	Histidine kinase
JEK78_RS19185	COG1725	Transcriptional regulator
JEK78_RS19195	COG2755	lipolytic protein G-D-S-L family
JEK78_RS19205	COG2188	Transcriptional regulator
JEK78_RS19210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JEK78_RS19220	COG0243	molybdopterin cofactor binding
JEK78_RS19255	COG3876	Protein conserved in bacteria
JEK78_RS19265	COG0318	PFAM AMP-dependent synthetase and ligase
JEK78_RS19290	COG2149	membrane
JEK78_RS19295	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JEK78_RS19355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JEK78_RS19380	COG0667	Aldo Keto reductase
JEK78_RS19385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JEK78_RS19395	COG0588	phosphoglycerate mutase activity
JEK78_RS19410	COG0215	cysteine-tRNA ligase activity
JEK78_RS19420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JEK78_RS19425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JEK78_RS19430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JEK78_RS19435	COG1414	Transcriptional regulator
JEK78_RS19440	COG0646	methionine synthase
JEK78_RS19440	COG1410	methionine synthase
JEK78_RS19445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JEK78_RS19450	COG4166	transmembrane transport
JEK78_RS19455	COG2197	response regulator
JEK78_RS19465	COG1994	Peptidase M50
JEK78_RS19465	COG0517	IMP dehydrogenase activity
JEK78_RS19480	COG1222	aaa ATPase
JEK78_RS19485	COG4122	O-methyltransferase activity
JEK78_RS19495	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JEK78_RS19500	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JEK78_RS19505	COG1609	Transcriptional regulator
JEK78_RS19515	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JEK78_RS19520	COG0545	Peptidyl-prolyl cis-trans isomerase
JEK78_RS19550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JEK78_RS19555	COG0805	protein transport
JEK78_RS19590	COG0564	pseudouridine synthase activity
JEK78_RS19600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JEK78_RS19640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JEK78_RS19645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JEK78_RS19650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JEK78_RS19655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JEK78_RS19660	COG5002	protein histidine kinase activity
JEK78_RS19665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JEK78_RS19670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JEK78_RS19670	COG0072	phenylalanine-tRNA ligase activity
JEK78_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS19685	COG0662	Cupin 2, conserved barrel domain protein
JEK78_RS19825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JEK78_RS19830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JEK78_RS19835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JEK78_RS19840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JEK78_RS19845	COG1438	arginine binding
JEK78_RS19850	COG1477	protein flavinylation
JEK78_RS19860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JEK78_RS19860	COG1017	nitric oxide dioxygenase activity
JEK78_RS19870	COG0137	argininosuccinate synthase activity
JEK78_RS19875	COG0165	Argininosuccinate lyase
JEK78_RS19885	COG0477	Major facilitator Superfamily
JEK78_RS19890	COG0204	Acyl-transferase
JEK78_RS19890	COG0318	PFAM AMP-dependent synthetase and ligase
JEK78_RS19920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JEK78_RS19925	COG2011	ABC-type metal ion transport system permease component
JEK78_RS19930	COG1464	Belongs to the NlpA lipoprotein family
JEK78_RS19945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JEK78_RS19950	COG1648	precorrin-2 dehydrogenase activity
JEK78_RS19950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JEK78_RS19990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JEK78_RS19990	COG0512	Glutamine amidotransferase of anthranilate synthase
JEK78_RS19995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JEK78_RS20045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JEK78_RS20060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JEK78_RS20065	COG1560	Kdo2-lipid A biosynthetic process
JEK78_RS20080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JEK78_RS20085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JEK78_RS20090	COG0217	transcriptional regulatory protein
JEK78_RS20095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JEK78_RS20100	COG0632	four-way junction helicase activity
JEK78_RS20105	COG2255	four-way junction helicase activity
JEK78_RS20115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JEK78_RS20120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JEK78_RS20125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JEK78_RS20130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JEK78_RS20135	COG1196	nuclear chromosome segregation
JEK78_RS20140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JEK78_RS20150	COG0124	histidyl-tRNA synthetase
JEK78_RS20165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JEK78_RS20180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JEK78_RS20185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JEK78_RS20195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JEK78_RS20200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JEK78_RS20205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JEK78_RS20210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JEK78_RS20220	COG0006	proline dipeptidase activity
JEK78_RS20225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JEK78_RS20230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JEK78_RS20240	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JEK78_RS20245	COG0540	Belongs to the ATCase OTCase family
JEK78_RS20250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JEK78_RS20260	COG0505	Belongs to the CarA family
JEK78_RS20265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JEK78_RS20270	COG0167	dihydroorotate dehydrogenase activity
JEK78_RS20275	COG0284	orotidine-5'-phosphate decarboxylase activity
JEK78_RS20285	COG0194	GDP metabolic process
JEK78_RS20290	COG1758	RNA polymerase activity
JEK78_RS20300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JEK78_RS20315	COG3547	Transposase (IS116 IS110 IS902 family)
JEK78_RS20320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JEK78_RS20330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JEK78_RS20335	COG2390	Transcriptional regulator
JEK78_RS20355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JEK78_RS20380	COG3201	nicotinamide mononucleotide transporter
JEK78_RS20385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JEK78_RS20385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JEK78_RS20390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JEK78_RS20395	COG0140	phosphoribosyl-ATP diphosphatase activity
JEK78_RS20400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JEK78_RS20415	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JEK78_RS20425	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS20435	COG1522	sequence-specific DNA binding
JEK78_RS20445	COG1216	Glycosyl transferase, family 2
JEK78_RS20460	COG2270	Major facilitator Superfamily
JEK78_RS20475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JEK78_RS20500	COG1984	allophanate hydrolase subunit 2
JEK78_RS20505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JEK78_RS20510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JEK78_RS20550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JEK78_RS20560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JEK78_RS20590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JEK78_RS20595	COG3879	Bacterial protein of unknown function (DUF881)
JEK78_RS20610	COG1716	ATPase activity
JEK78_RS20630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JEK78_RS20640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JEK78_RS20640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JEK78_RS20720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JEK78_RS20730	COG2318	DinB family
JEK78_RS20735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JEK78_RS20760	COG1968	undecaprenyl-diphosphatase activity
JEK78_RS20770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JEK78_RS20785	COG0110	maltose O-acetyltransferase activity
JEK78_RS20795	COG1832	CoA-binding protein
JEK78_RS20800	COG1739	Uncharacterized protein family UPF0029
JEK78_RS20805	COG0420	3'-5' exonuclease activity
JEK78_RS20810	COG0419	ATPase involved in DNA repair
JEK78_RS20820	COG1522	sequence-specific DNA binding
JEK78_RS20825	COG0626	cystathionine gamma-synthase activity
JEK78_RS20840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JEK78_RS20860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JEK78_RS20865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JEK78_RS20870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JEK78_RS20875	COG0156	8-amino-7-oxononanoate synthase activity
JEK78_RS20890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JEK78_RS20895	COG1834	amidinotransferase
JEK78_RS20900	COG1522	sequence-specific DNA binding
JEK78_RS20915	COG0205	6-phosphofructokinase activity
JEK78_RS20920	COG3442	glutamine amidotransferase
JEK78_RS20930	COG0242	peptide deformylase activity
JEK78_RS20940	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS20950	COG1012	belongs to the aldehyde dehydrogenase family
JEK78_RS20985	COG3896	Chloramphenicol phosphotransferase-like protein
JEK78_RS20995	COG1366	Belongs to the anti-sigma-factor antagonist family
JEK78_RS21000	COG1278	Cold shock
JEK78_RS21015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JEK78_RS21020	COG4134	Bacterial extracellular solute-binding protein
JEK78_RS21035	COG3842	ATPase activity
JEK78_RS21075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JEK78_RS21080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JEK78_RS21085	COG1652	LysM domain
JEK78_RS21110	COG1609	Transcriptional regulator
JEK78_RS21115	COG1653	transport
JEK78_RS21120	COG1175	transmembrane transport
JEK78_RS21125	COG0395	ABC-type sugar transport system, permease component
JEK78_RS21145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JEK78_RS21160	COG0726	polysaccharide deacetylase
JEK78_RS21195	COG0583	DNA-binding transcription factor activity
JEK78_RS21205	COG1053	succinate dehydrogenase
JEK78_RS21210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JEK78_RS21215	COG3360	Dodecin
JEK78_RS21220	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
JEK78_RS21225	COG0121	glutamine amidotransferase
JEK78_RS21230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JEK78_RS21235	COG3572	ergothioneine biosynthetic process
JEK78_RS21250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JEK78_RS21255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JEK78_RS21275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JEK78_RS21290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JEK78_RS21290	COG4651	solute:proton antiporter activity
JEK78_RS21300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JEK78_RS21300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JEK78_RS21310	COG1937	Protein conserved in bacteria
JEK78_RS21315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JEK78_RS21355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JEK78_RS21355	COG0574	Belongs to the PEP-utilizing enzyme family
JEK78_RS21405	COG3540	Alkaline phosphatase
JEK78_RS21425	COG1357	PFAM Pentapeptide repeats (8 copies)
JEK78_RS21445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JEK78_RS21445	COG1796	DNA polymerase
JEK78_RS21500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JEK78_RS21550	COG2409	Drug exporters of the RND superfamily
JEK78_RS21555	COG0673	inositol 2-dehydrogenase activity
JEK78_RS21610	COG3290	protein histidine kinase activity
JEK78_RS21630	COG0277	FAD linked oxidase domain protein
JEK78_RS21655	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
JEK78_RS21670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS21680	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JEK78_RS21690	COG0713	ATP synthesis coupled electron transport
JEK78_RS21695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JEK78_RS21700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JEK78_RS21705	COG1007	ATP synthesis coupled electron transport
JEK78_RS21735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JEK78_RS21745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JEK78_RS21750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JEK78_RS21760	COG0438	transferase activity, transferring glycosyl groups
JEK78_RS21775	COG0477	Major facilitator Superfamily
JEK78_RS21780	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
JEK78_RS21795	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS21800	COG1024	Enoyl-CoA hydratase
JEK78_RS21805	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS21810	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS21815	COG1309	transcriptional regulator
JEK78_RS21840	COG1024	Enoyl-CoA hydratase
JEK78_RS21870	COG0745	RESPONSE REGULATOR receiver
JEK78_RS21875	COG2205	protein histidine kinase activity
JEK78_RS21880	COG2340	Cysteine-rich secretory protein family
JEK78_RS21895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JEK78_RS21900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JEK78_RS21905	COG1294	oxidase, subunit
JEK78_RS21910	COG1271	oxidase subunit
JEK78_RS21935	COG3835	regulator
JEK78_RS22020	COG1131	(ABC) transporter
JEK78_RS22055	COG3903	Transcriptional regulator
JEK78_RS22055	COG3629	intracellular signal transduction
JEK78_RS22075	COG2226	methyltransferase
JEK78_RS22100	COG4106	trans-aconitate 2-methyltransferase activity
JEK78_RS22135	COG1132	(ABC) transporter
JEK78_RS22140	COG1132	(ABC) transporter
JEK78_RS22190	COG0673	inositol 2-dehydrogenase activity
JEK78_RS22200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JEK78_RS22220	COG3173	Aminoglycoside phosphotransferase
JEK78_RS22240	COG0745	RESPONSE REGULATOR receiver
JEK78_RS22245	COG3979	chitinase
JEK78_RS22260	COG1022	Amp-dependent synthetase and ligase
JEK78_RS22290	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS22305	COG0633	Ferredoxin
JEK78_RS22305	COG0543	2 iron, 2 sulfur cluster binding
JEK78_RS22310	COG1233	COG1233 Phytoene dehydrogenase and related
JEK78_RS22315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS22335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JEK78_RS22345	COG2030	dehydratase
JEK78_RS22365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JEK78_RS22370	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS22400	COG1113	amino acid transport
JEK78_RS22415	COG3340	Belongs to the peptidase S51 family
JEK78_RS22440	COG0583	DNA-binding transcription factor activity
JEK78_RS22445	COG3629	intracellular signal transduction
JEK78_RS22465	COG1028	Short-chain dehydrogenase reductase Sdr
JEK78_RS22485	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JEK78_RS22490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JEK78_RS22515	COG0655	NAD(P)H dehydrogenase (quinone) activity
JEK78_RS22520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS22550	COG1063	alcohol dehydrogenase
JEK78_RS22655	COG0488	(ABC) transporter
JEK78_RS22675	COG2318	DinB family
JEK78_RS22755	COG4974	Belongs to the 'phage' integrase family
JEK78_RS22860	COG2801	Transposase and inactivated derivatives
JEK78_RS22925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JEK78_RS22935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JEK78_RS22945	COG3629	intracellular signal transduction
JEK78_RS22950	COG0156	8-amino-7-oxononanoate synthase activity
JEK78_RS22960	COG2030	dehydratase
JEK78_RS22965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JEK78_RS22975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JEK78_RS22980	COG0159	tryptophan synthase activity
JEK78_RS22985	COG0662	Cupin 2, conserved barrel domain protein
JEK78_RS22990	COG1960	acyl-CoA dehydrogenase activity
JEK78_RS23000	COG0134	indole-3-glycerol-phosphate synthase activity
JEK78_RS23050	COG1278	Cold shock