locus-tag	class	description
N8I86_RS00065	COG0222	ribosome binding
N8I86_RS00130	COG3629	intracellular signal transduction
N8I86_RS00130	COG3903	Transcriptional regulator
N8I86_RS00155	COG1278	Cold shock
N8I86_RS00195	COG1278	Cold shock
N8I86_RS00305	COG3293	Transposase
N8I86_RS00410	COG1595	DNA-templated transcription, initiation
N8I86_RS00420	COG0187	DNA topoisomerase II activity
N8I86_RS00470	COG4221	oxidoreductase activity
N8I86_RS00485	COG0789	Transcriptional regulator
N8I86_RS00490	COG0583	DNA-binding transcription factor activity
N8I86_RS00510	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8I86_RS00510	COG1024	Enoyl-CoA hydratase
N8I86_RS00525	COG1309	transcriptional regulator
N8I86_RS00535	COG2124	cytochrome p450
N8I86_RS00535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N8I86_RS00555	COG0778	Nitroreductase
N8I86_RS00560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N8I86_RS00565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8I86_RS00570	COG0179	Fumarylacetoacetate (FAA) hydrolase
N8I86_RS00595	COG2124	cytochrome p450
N8I86_RS00615	COG1278	Cold shock
N8I86_RS00620	COG0655	NAD(P)H dehydrogenase (quinone) activity
N8I86_RS00685	COG4221	oxidoreductase activity
N8I86_RS00695	COG0640	Transcriptional regulator
N8I86_RS00705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N8I86_RS00715	COG1397	ADP-ribosylglycohydrolase
N8I86_RS00745	COG0542	response to heat
N8I86_RS00760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N8I86_RS00765	COG0443	Heat shock 70 kDa protein
N8I86_RS00775	COG0047	phosphoribosylformylglycinamidine synthase activity
N8I86_RS00795	COG0431	NADPH-dependent FMN reductase
N8I86_RS00800	COG0656	L-ascorbic acid biosynthetic process
N8I86_RS00810	COG0583	DNA-binding transcription factor activity
N8I86_RS00820	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS00840	COG0702	epimerase
N8I86_RS00890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8I86_RS00920	COG1181	Belongs to the D-alanine--D-alanine ligase family
N8I86_RS00925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS00935	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
N8I86_RS01055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8I86_RS01065	COG2130	NADP-dependent
N8I86_RS01080	COG0513	Belongs to the DEAD box helicase family
N8I86_RS01090	COG1595	DNA-templated transcription, initiation
N8I86_RS01105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N8I86_RS01110	COG2329	Antibiotic biosynthesis monooxygenase
N8I86_RS01120	COG0640	Transcriptional regulator
N8I86_RS01155	COG0583	DNA-binding transcription factor activity
N8I86_RS01170	COG1053	succinate dehydrogenase
N8I86_RS01170	COG3976	FMN-binding domain protein
N8I86_RS01185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8I86_RS01185	COG0473	3-isopropylmalate dehydrogenase activity
N8I86_RS01195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8I86_RS01230	COG1278	Cold shock
N8I86_RS01315	COG2226	methyltransferase
N8I86_RS01340	COG2326	polyphosphate kinase activity
N8I86_RS01355	COG2124	cytochrome p450
N8I86_RS01365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N8I86_RS01365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N8I86_RS01385	COG4977	sequence-specific DNA binding
N8I86_RS01405	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8I86_RS01405	COG0567	Dehydrogenase, E1 component
N8I86_RS01415	COG2814	Major facilitator Superfamily
N8I86_RS01485	COG0297	glycogen (starch) synthase activity
N8I86_RS01490	COG3629	intracellular signal transduction
N8I86_RS01490	COG3903	Transcriptional regulator
N8I86_RS01595	COG0515	serine threonine protein kinase
N8I86_RS01605	COG1132	(ABC) transporter
N8I86_RS01610	COG1132	(ABC) transporter
N8I86_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS01625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8I86_RS01635	COG0477	Major facilitator Superfamily
N8I86_RS01660	COG2080	2 iron, 2 sulfur cluster binding
N8I86_RS01665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N8I86_RS01670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8I86_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS01720	COG0201	protein transport
N8I86_RS01730	COG1309	transcriptional regulator
N8I86_RS01735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8I86_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS01775	COG0483	inositol monophosphate 1-phosphatase activity
N8I86_RS01805	COG2770	Histidine kinase
N8I86_RS01805	COG2208	phosphoserine phosphatase activity
N8I86_RS01895	COG0477	Major facilitator Superfamily
N8I86_RS01900	COG0583	DNA-binding transcription factor activity
N8I86_RS01950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N8I86_RS01965	COG4191	Histidine kinase
N8I86_RS01970	COG1191	sigma factor activity
N8I86_RS01975	COG0477	Major facilitator Superfamily
N8I86_RS01980	COG0477	Major facilitator Superfamily
N8I86_RS02005	COG3046	protein related to deoxyribodipyrimidine photolyase
N8I86_RS02075	COG1937	Protein conserved in bacteria
N8I86_RS02080	COG0730	response to heat
N8I86_RS02085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N8I86_RS02090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8I86_RS02090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N8I86_RS02100	COG0516	GMP reductase activity
N8I86_RS02100	COG0517	IMP dehydrogenase activity
N8I86_RS02105	COG0517	IMP dehydrogenase activity
N8I86_RS02105	COG0516	GMP reductase activity
N8I86_RS02125	COG1063	alcohol dehydrogenase
N8I86_RS02130	COG0589	response to stress
N8I86_RS02140	COG0517	IMP dehydrogenase activity
N8I86_RS02140	COG1125	glycine betaine transport
N8I86_RS02150	COG0395	ABC-type sugar transport system, permease component
N8I86_RS02155	COG1175	transmembrane transport
N8I86_RS02165	COG0454	-acetyltransferase
N8I86_RS02165	COG0456	acetyltransferase
N8I86_RS02170	COG3876	Protein conserved in bacteria
N8I86_RS02175	COG1309	transcriptional regulator
N8I86_RS02180	COG0493	'glutamate synthase
N8I86_RS02180	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N8I86_RS02190	COG3250	beta-galactosidase activity
N8I86_RS02195	COG1609	Transcriptional regulator
N8I86_RS02200	COG1879	ABC-type sugar transport system periplasmic component
N8I86_RS02215	COG1172	Belongs to the binding-protein-dependent transport system permease family
N8I86_RS02275	COG2814	Major facilitator Superfamily
N8I86_RS02295	COG1968	undecaprenyl-diphosphatase activity
N8I86_RS02305	COG0586	Pfam SNARE associated Golgi protein
N8I86_RS02340	COG1595	DNA-templated transcription, initiation
N8I86_RS02390	COG1595	DNA-templated transcription, initiation
N8I86_RS02395	COG0668	transmembrane transport
N8I86_RS02400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N8I86_RS02415	COG1104	cysteine desulfurase activity
N8I86_RS02455	COG1309	transcriptional regulator
N8I86_RS02465	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS02480	COG4106	trans-aconitate 2-methyltransferase activity
N8I86_RS02485	COG1129	ABC transporter
N8I86_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS02510	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
N8I86_RS02545	COG0513	Belongs to the DEAD box helicase family
N8I86_RS02550	COG1278	Cold shock
N8I86_RS02575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N8I86_RS02590	COG1131	(ABC) transporter
N8I86_RS02605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N8I86_RS02610	COG1414	Transcriptional regulator
N8I86_RS02620	COG2770	Histidine kinase
N8I86_RS02620	COG2208	phosphoserine phosphatase activity
N8I86_RS02645	COG3250	beta-galactosidase activity
N8I86_RS02650	COG0277	FAD linked oxidase domain protein
N8I86_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS02710	COG0583	DNA-binding transcription factor activity
N8I86_RS02715	COG5640	endopeptidase activity
N8I86_RS02795	COG1295	ribonuclease BN
N8I86_RS02810	COG1309	transcriptional regulator
N8I86_RS02815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N8I86_RS02840	COG2755	lipolytic protein G-D-S-L family
N8I86_RS02870	COG0701	Predicted permease
N8I86_RS02885	COG1595	DNA-templated transcription, initiation
N8I86_RS02900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N8I86_RS02910	COG2409	Drug exporters of the RND superfamily
N8I86_RS02915	COG1309	transcriptional regulator
N8I86_RS02970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8I86_RS02990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N8I86_RS02995	COG5002	protein histidine kinase activity
N8I86_RS03000	COG0745	RESPONSE REGULATOR receiver
N8I86_RS03045	COG0254	rRNA binding
N8I86_RS03050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N8I86_RS03060	COG1309	transcriptional regulator
N8I86_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS03070	COG0456	acetyltransferase
N8I86_RS03080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N8I86_RS03085	COG0596	Alpha beta hydrolase
N8I86_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS03145	COG3511	phospholipase C
N8I86_RS03165	COG1191	sigma factor activity
N8I86_RS03190	COG1316	TRANSCRIPTIONal
N8I86_RS03195	COG0640	Transcriptional regulator
N8I86_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS03220	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS03235	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
N8I86_RS03325	COG0673	inositol 2-dehydrogenase activity
N8I86_RS03335	COG1172	Belongs to the binding-protein-dependent transport system permease family
N8I86_RS03340	COG1129	ABC transporter
N8I86_RS03345	COG1940	carbohydrate kinase activity
N8I86_RS03365	COG2226	methyltransferase
N8I86_RS03385	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N8I86_RS03410	COG0375	protein maturation
N8I86_RS03425	COG0298	carbon dioxide binding
N8I86_RS03430	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N8I86_RS03440	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N8I86_RS03515	COG1595	DNA-templated transcription, initiation
N8I86_RS03520	COG1302	Protein conserved in bacteria
N8I86_RS03550	COG0517	IMP dehydrogenase activity
N8I86_RS03570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N8I86_RS03580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8I86_RS03660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N8I86_RS03665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8I86_RS03675	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS03700	COG2755	lipolytic protein G-D-S-L family
N8I86_RS03715	COG0477	Major facilitator Superfamily
N8I86_RS03720	COG0667	Aldo Keto reductase
N8I86_RS03740	COG0586	Pfam SNARE associated Golgi protein
N8I86_RS03755	COG2814	Major facilitator Superfamily
N8I86_RS03785	COG0437	4 iron, 4 sulfur cluster binding
N8I86_RS03805	COG0709	Synthesizes selenophosphate from selenide and ATP
N8I86_RS03850	COG3291	Pkd domain containing protein
N8I86_RS03910	COG0673	inositol 2-dehydrogenase activity
N8I86_RS03955	COG0009	L-threonylcarbamoyladenylate synthase
N8I86_RS04015	COG0667	Aldo Keto reductase
N8I86_RS04055	COG5006	permease, DMT superfamily
N8I86_RS04070	COG1309	transcriptional regulator
N8I86_RS04085	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS04100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N8I86_RS04120	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8I86_RS04125	COG1177	transmembrane transport
N8I86_RS04130	COG3842	ATPase activity
N8I86_RS04140	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS04145	COG0181	hydroxymethylbilane synthase activity
N8I86_RS04195	COG0366	Alpha amylase catalytic
N8I86_RS04210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N8I86_RS04215	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N8I86_RS04285	COG5002	protein histidine kinase activity
N8I86_RS04325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8I86_RS04400	COG0142	geranyltranstransferase activity
N8I86_RS04405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N8I86_RS04410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8I86_RS04410	COG0515	serine threonine protein kinase
N8I86_RS04430	COG3647	Membrane
N8I86_RS04440	COG0667	Aldo Keto reductase
N8I86_RS04475	COG0328	RNA-DNA hybrid ribonuclease activity
N8I86_RS04485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8I86_RS04495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N8I86_RS04510	COG0596	Alpha beta hydrolase
N8I86_RS04515	COG1396	sequence-specific DNA binding
N8I86_RS04520	COG1191	sigma factor activity
N8I86_RS04550	COG0842	Transport permease protein
N8I86_RS04550	COG1131	(ABC) transporter
N8I86_RS04550	COG1716	ATPase activity
N8I86_RS04575	COG0667	Aldo Keto reductase
N8I86_RS04580	COG0583	DNA-binding transcription factor activity
N8I86_RS04590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N8I86_RS04595	COG0346	lactoylglutathione lyase activity
N8I86_RS04605	COG0667	Aldo Keto reductase
N8I86_RS04610	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS04615	COG4941	Belongs to the sigma-70 factor family
N8I86_RS04645	COG0702	epimerase
N8I86_RS04670	COG0531	amino acid
N8I86_RS04675	COG1940	carbohydrate kinase activity
N8I86_RS04680	COG3250	beta-galactosidase activity
N8I86_RS04735	COG0367	asparagine synthase
N8I86_RS04750	COG0673	inositol 2-dehydrogenase activity
N8I86_RS04770	COG0510	thiamine kinase activity
N8I86_RS04820	COG1024	Enoyl-CoA hydratase
N8I86_RS04840	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS04850	COG2070	2-Nitropropane dioxygenase
N8I86_RS04855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N8I86_RS04865	COG0515	serine threonine protein kinase
N8I86_RS04875	COG1309	transcriptional regulator
N8I86_RS04880	COG1902	pentaerythritol trinitrate reductase activity
N8I86_RS04905	COG0745	RESPONSE REGULATOR receiver
N8I86_RS04930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8I86_RS04945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS04955	COG0431	NADPH-dependent FMN reductase
N8I86_RS04960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS04965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS04975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS04990	COG1126	abc transporter atp-binding protein
N8I86_RS05010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N8I86_RS05025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS05035	COG1116	anion transmembrane transporter activity
N8I86_RS05040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8I86_RS05055	COG0477	Major facilitator Superfamily
N8I86_RS05075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS05080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS05085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS05105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8I86_RS05110	COG4172	Belongs to the ABC transporter superfamily
N8I86_RS05115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS05120	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS05135	COG0698	ribose 5-phosphate isomerase
N8I86_RS05160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N8I86_RS05160	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N8I86_RS05165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N8I86_RS05170	COG0297	glycogen (starch) synthase activity
N8I86_RS05175	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS05195	COG2192	nodulation
N8I86_RS05200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8I86_RS05215	COG2376	Dihydroxyacetone kinase
N8I86_RS05220	COG1461	Dihydroxyacetone kinase
N8I86_RS05225	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
N8I86_RS05250	COG1902	pentaerythritol trinitrate reductase activity
N8I86_RS05250	COG0446	pyridine nucleotide-disulphide oxidoreductase
N8I86_RS05270	COG2890	protein-(glutamine-N5) methyltransferase activity
N8I86_RS05280	COG0714	Associated with various cellular activities
N8I86_RS05305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N8I86_RS05325	COG3458	cephalosporin-C deacetylase activity
N8I86_RS05330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N8I86_RS05340	COG2226	methyltransferase
N8I86_RS05345	COG1695	Transcriptional regulator
N8I86_RS05365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N8I86_RS05370	COG1686	Belongs to the peptidase S11 family
N8I86_RS05375	COG1051	belongs to the nudix hydrolase family
N8I86_RS05385	COG2066	Belongs to the glutaminase family
N8I86_RS05405	COG2186	Transcriptional regulator
N8I86_RS05410	COG1968	undecaprenyl-diphosphatase activity
N8I86_RS05415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N8I86_RS05420	COG1993	acr, cog1993
N8I86_RS05425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N8I86_RS05500	COG4191	Histidine kinase
N8I86_RS05510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8I86_RS05530	COG1181	Belongs to the D-alanine--D-alanine ligase family
N8I86_RS05535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N8I86_RS05545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS05555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS05565	COG0069	glutamate synthase activity
N8I86_RS05570	COG0017	Asparaginyl-tRNA synthetase
N8I86_RS05595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N8I86_RS05625	COG0477	Major facilitator Superfamily
N8I86_RS05635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N8I86_RS05640	COG2151	metal-sulfur cluster biosynthetic enzyme
N8I86_RS05645	COG3396	Phenylacetate-CoA oxygenase
N8I86_RS05650	COG3460	Phenylacetate-CoA oxygenase
N8I86_RS05655	COG3396	Phenylacetate-CoA oxygenase
N8I86_RS05660	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8I86_RS05665	COG0183	Belongs to the thiolase family
N8I86_RS05670	COG2050	protein possibly involved in aromatic compounds catabolism
N8I86_RS05710	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS05710	COG2172	sigma factor antagonist activity
N8I86_RS05710	COG2208	phosphoserine phosphatase activity
N8I86_RS05725	COG1408	metallophosphoesterase
N8I86_RS05745	COG0702	epimerase
N8I86_RS05750	COG1733	regulation of RNA biosynthetic process
N8I86_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS05790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N8I86_RS05795	COG1215	transferase activity, transferring glycosyl groups
N8I86_RS05830	COG1349	DNA-binding transcription factor activity
N8I86_RS05860	COG1136	(ABC) transporter
N8I86_RS05870	COG1940	carbohydrate kinase activity
N8I86_RS05875	COG3145	DNA-N1-methyladenine dioxygenase activity
N8I86_RS05880	COG2813	Specifically methylates the guanine in position
N8I86_RS05895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N8I86_RS05900	COG1349	DNA-binding transcription factor activity
N8I86_RS05930	COG2197	response regulator
N8I86_RS05935	COG4585	Histidine kinase
N8I86_RS05965	COG1660	Displays ATPase and GTPase activities
N8I86_RS06005	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N8I86_RS06030	COG0204	Acyl-transferase
N8I86_RS06055	COG0584	glycerophosphoryl diester phosphodiesterase
N8I86_RS06075	COG1846	Transcriptional regulator
N8I86_RS06145	COG1309	transcriptional regulator
N8I86_RS06155	COG0640	Transcriptional regulator
N8I86_RS06180	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS06200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N8I86_RS06205	COG2971	BadF BadG BcrA BcrD
N8I86_RS06215	COG2706	6-phosphogluconolactonase activity
N8I86_RS06235	COG0477	Major facilitator Superfamily
N8I86_RS06255	COG0432	Pfam Uncharacterised protein family UPF0047
N8I86_RS06260	COG2072	flavoprotein involved in K transport
N8I86_RS06270	COG1132	(ABC) transporter
N8I86_RS06305	COG1132	(ABC) transporter
N8I86_RS06315	COG0254	rRNA binding
N8I86_RS06330	COG1946	Acyl-CoA thioesterase
N8I86_RS06340	COG2018	Roadblock/LC7 domain
N8I86_RS06405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N8I86_RS06425	COG1070	Carbohydrate kinase
N8I86_RS06430	COG1846	Transcriptional regulator
N8I86_RS06430	COG1940	carbohydrate kinase activity
N8I86_RS06445	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS06475	COG0159	tryptophan synthase activity
N8I86_RS06530	COG1201	RNA secondary structure unwinding
N8I86_RS06535	COG0494	nUDIX hydrolase
N8I86_RS06630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N8I86_RS06675	COG4942	peptidase
N8I86_RS06720	COG0586	Pfam SNARE associated Golgi protein
N8I86_RS06765	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS06770	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS06785	COG0492	ferredoxin-NADP+ reductase activity
N8I86_RS06790	COG1793	dna ligase
N8I86_RS06810	COG3424	synthase
N8I86_RS06815	COG2124	cytochrome p450
N8I86_RS06825	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS06835	COG0242	peptide deformylase activity
N8I86_RS06845	COG3442	glutamine amidotransferase
N8I86_RS06850	COG0205	6-phosphofructokinase activity
N8I86_RS06865	COG1522	sequence-specific DNA binding
N8I86_RS06870	COG1834	amidinotransferase
N8I86_RS06875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N8I86_RS06880	COG0204	Acyl-transferase
N8I86_RS06900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N8I86_RS06905	COG0830	nickel cation binding
N8I86_RS06910	COG0804	urea catabolic process
N8I86_RS06915	COG0832	Belongs to the urease beta subunit family
N8I86_RS06920	COG0831	urea catabolic process
N8I86_RS06930	COG0740	serine-type endopeptidase activity
N8I86_RS06965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N8I86_RS06970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N8I86_RS06975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N8I86_RS06980	COG2226	methyltransferase
N8I86_RS06995	COG0577	efflux transmembrane transporter activity
N8I86_RS06995	COG1136	(ABC) transporter
N8I86_RS07000	COG1136	(ABC) transporter
N8I86_RS07000	COG0577	efflux transmembrane transporter activity
N8I86_RS07010	COG0456	acetyltransferase
N8I86_RS07030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N8I86_RS07035	COG3663	DNA glycosylase
N8I86_RS07050	COG4585	Histidine kinase
N8I86_RS07055	COG2197	response regulator
N8I86_RS07060	COG1940	carbohydrate kinase activity
N8I86_RS07070	COG2188	Transcriptional regulator
N8I86_RS07075	COG1595	DNA-templated transcription, initiation
N8I86_RS07080	COG0596	Alpha beta hydrolase
N8I86_RS07105	COG0626	cystathionine gamma-synthase activity
N8I86_RS07150	COG1522	sequence-specific DNA binding
N8I86_RS07160	COG0420	3'-5' exonuclease activity
N8I86_RS07165	COG1739	Uncharacterized protein family UPF0029
N8I86_RS07180	COG1832	CoA-binding protein
N8I86_RS07185	COG0531	amino acid
N8I86_RS07195	COG0640	Transcriptional regulator
N8I86_RS07220	COG0110	maltose O-acetyltransferase activity
N8I86_RS07265	COG3321	synthase
N8I86_RS07265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS07275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N8I86_RS07300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N8I86_RS07315	COG0183	Belongs to the thiolase family
N8I86_RS07325	COG1968	undecaprenyl-diphosphatase activity
N8I86_RS07350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N8I86_RS07380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N8I86_RS07385	COG4166	transmembrane transport
N8I86_RS07430	COG0697	spore germination
N8I86_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS07520	COG3833	ABC-type maltose transport systems, permease component
N8I86_RS07565	COG0725	ABC transporter, periplasmic molybdate-binding protein
N8I86_RS07585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N8I86_RS07585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N8I86_RS07595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N8I86_RS07615	COG1716	ATPase activity
N8I86_RS07635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N8I86_RS07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N8I86_RS07675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N8I86_RS07695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8I86_RS07700	COG3706	GGDEF domain
N8I86_RS07705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N8I86_RS07710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N8I86_RS07730	COG2018	Roadblock/LC7 domain
N8I86_RS07745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N8I86_RS07750	COG2146	nitrite reductase [NAD(P)H] activity
N8I86_RS07755	COG1414	Transcriptional regulator
N8I86_RS07785	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS07790	COG0531	amino acid
N8I86_RS07820	COG2814	Major facilitator Superfamily
N8I86_RS07825	COG4336	lyase activity
N8I86_RS07830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N8I86_RS07835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N8I86_RS07840	COG1984	allophanate hydrolase subunit 2
N8I86_RS07850	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS07855	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS07885	COG2364	Membrane
N8I86_RS07890	COG0584	glycerophosphoryl diester phosphodiesterase
N8I86_RS07895	COG2270	Major facilitator Superfamily
N8I86_RS07910	COG1216	Glycosyl transferase, family 2
N8I86_RS07940	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS08000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N8I86_RS08005	COG0140	phosphoribosyl-ATP diphosphatase activity
N8I86_RS08010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N8I86_RS08015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N8I86_RS08015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N8I86_RS08020	COG3201	nicotinamide mononucleotide transporter
N8I86_RS08035	COG1846	Transcriptional regulator
N8I86_RS08035	COG1940	carbohydrate kinase activity
N8I86_RS08040	COG2223	nitrite transmembrane transporter activity
N8I86_RS08060	COG2233	PERMEase
N8I86_RS08080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N8I86_RS08105	COG3842	ATPase activity
N8I86_RS08125	COG2188	Transcriptional regulator
N8I86_RS08135	COG0531	amino acid
N8I86_RS08155	COG2390	Transcriptional regulator
N8I86_RS08160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N8I86_RS08170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N8I86_RS08185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N8I86_RS08200	COG0194	GDP metabolic process
N8I86_RS08210	COG0284	orotidine-5'-phosphate decarboxylase activity
N8I86_RS08215	COG0167	dihydroorotate dehydrogenase activity
N8I86_RS08220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N8I86_RS08225	COG0505	Belongs to the CarA family
N8I86_RS08235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N8I86_RS08240	COG0540	Belongs to the ATCase OTCase family
N8I86_RS08245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N8I86_RS08255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N8I86_RS08260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N8I86_RS08265	COG0006	proline dipeptidase activity
N8I86_RS08275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N8I86_RS08280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N8I86_RS08285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N8I86_RS08290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N8I86_RS08300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N8I86_RS08305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N8I86_RS08325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N8I86_RS08340	COG0124	histidyl-tRNA synthetase
N8I86_RS08350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N8I86_RS08355	COG1196	nuclear chromosome segregation
N8I86_RS08360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N8I86_RS08370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8I86_RS08375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8I86_RS08385	COG2255	four-way junction helicase activity
N8I86_RS08390	COG0632	four-way junction helicase activity
N8I86_RS08395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N8I86_RS08400	COG0217	transcriptional regulatory protein
N8I86_RS08405	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
N8I86_RS08410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
N8I86_RS08420	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS08425	COG1560	Kdo2-lipid A biosynthetic process
N8I86_RS08430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N8I86_RS08450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N8I86_RS08455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N8I86_RS08470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N8I86_RS08530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N8I86_RS08585	COG1648	precorrin-2 dehydrogenase activity
N8I86_RS08585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N8I86_RS08605	COG1464	Belongs to the NlpA lipoprotein family
N8I86_RS08610	COG2011	ABC-type metal ion transport system permease component
N8I86_RS08615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N8I86_RS08655	COG2132	Multicopper oxidase
N8I86_RS08660	COG0477	Major facilitator Superfamily
N8I86_RS08675	COG0165	Argininosuccinate lyase
N8I86_RS08680	COG0137	argininosuccinate synthase activity
N8I86_RS08695	COG2205	protein histidine kinase activity
N8I86_RS08700	COG0745	RESPONSE REGULATOR receiver
N8I86_RS08735	COG1132	(ABC) transporter
N8I86_RS08755	COG1438	arginine binding
N8I86_RS08760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N8I86_RS08765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N8I86_RS08770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N8I86_RS08775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N8I86_RS08785	COG0463	Glycosyl transferase, family 2
N8I86_RS08820	COG0697	spore germination
N8I86_RS08860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8I86_RS08860	COG0072	phenylalanine-tRNA ligase activity
N8I86_RS08865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N8I86_RS08870	COG5002	protein histidine kinase activity
N8I86_RS08875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N8I86_RS08880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N8I86_RS08885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N8I86_RS08890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N8I86_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS08940	COG0174	glutamine synthetase
N8I86_RS08945	COG2186	Transcriptional regulator
N8I86_RS08950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N8I86_RS08980	COG4176	ABC-type proline glycine betaine transport system permease component
N8I86_RS08985	COG4175	Glycine betaine
N8I86_RS08985	COG0517	IMP dehydrogenase activity
N8I86_RS08990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N8I86_RS09010	COG0564	pseudouridine synthase activity
N8I86_RS09045	COG0805	protein transport
N8I86_RS09050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N8I86_RS09085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N8I86_RS09095	COG1609	Transcriptional regulator
N8I86_RS09100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N8I86_RS09105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N8I86_RS09120	COG4122	O-methyltransferase activity
N8I86_RS09125	COG1222	aaa ATPase
N8I86_RS09145	COG0517	IMP dehydrogenase activity
N8I86_RS09145	COG1994	Peptidase M50
N8I86_RS09155	COG2197	response regulator
N8I86_RS09160	COG0747	negative chemotaxis
N8I86_RS09165	COG0747	negative chemotaxis
N8I86_RS09175	COG0646	methionine synthase
N8I86_RS09175	COG1410	methionine synthase
N8I86_RS09180	COG1414	Transcriptional regulator
N8I86_RS09185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N8I86_RS09190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N8I86_RS09195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N8I86_RS09200	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
N8I86_RS09205	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
N8I86_RS09210	COG0235	Class ii aldolase
N8I86_RS09225	COG0215	cysteine-tRNA ligase activity
N8I86_RS09245	COG0598	Magnesium transport protein CorA
N8I86_RS09255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS09260	COG0667	Aldo Keto reductase
N8I86_RS09295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8I86_RS09320	COG3012	SEC-C Motif Domain Protein
N8I86_RS09325	COG2186	Transcriptional regulator
N8I86_RS09330	COG3265	gluconokinase activity
N8I86_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS09345	COG1063	alcohol dehydrogenase
N8I86_RS09375	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N8I86_RS09380	COG2149	membrane
N8I86_RS09415	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS09425	COG3876	Protein conserved in bacteria
N8I86_RS09455	COG0789	Transcriptional regulator
N8I86_RS09475	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS09485	COG0640	Transcriptional regulator
N8I86_RS09525	COG2851	Citrate transporter
N8I86_RS09530	COG0243	molybdopterin cofactor binding
N8I86_RS09545	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N8I86_RS09550	COG2188	Transcriptional regulator
N8I86_RS09580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8I86_RS09595	COG1595	DNA-templated transcription, initiation
N8I86_RS09620	COG2755	lipolytic protein G-D-S-L family
N8I86_RS09635	COG1725	Transcriptional regulator
N8I86_RS09650	COG2226	methyltransferase
N8I86_RS09680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N8I86_RS09680	COG0662	Cupin 2, conserved barrel domain protein
N8I86_RS09685	COG0587	DNA-directed DNA polymerase activity
N8I86_RS09690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N8I86_RS09735	COG1799	cell septum assembly
N8I86_RS09740	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS09745	COG0477	Major facilitator Superfamily
N8I86_RS09755	COG0671	phosphoesterase, PA-phosphatase related
N8I86_RS09770	COG1652	LysM domain
N8I86_RS09785	COG1160	GTP binding
N8I86_RS09795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N8I86_RS09820	COG3541	Predicted nucleotidyltransferase
N8I86_RS09825	COG1397	ADP-ribosylglycohydrolase
N8I86_RS09830	COG1187	pseudouridine synthase activity
N8I86_RS09835	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N8I86_RS09840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N8I86_RS09855	COG0686	Belongs to the AlaDH PNT family
N8I86_RS09865	COG0494	nUDIX hydrolase
N8I86_RS09870	COG0504	CTP synthase activity
N8I86_RS09875	COG3387	PFAM Glycoside hydrolase 15-related
N8I86_RS09890	COG0297	glycogen (starch) synthase activity
N8I86_RS09900	COG0497	DNA recombination
N8I86_RS09905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N8I86_RS09925	COG1120	ATPase activity
N8I86_RS09930	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N8I86_RS09935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N8I86_RS09940	COG0647	UMP catabolic process
N8I86_RS09975	COG2094	Belongs to the DNA glycosylase MPG family
N8I86_RS09985	COG1881	PFAM PEBP family protein
N8I86_RS10005	COG1119	ATPase activity
N8I86_RS10020	COG2197	response regulator
N8I86_RS10035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N8I86_RS10045	COG1716	ATPase activity
N8I86_RS10045	COG1131	(ABC) transporter
N8I86_RS10045	COG0842	Transport permease protein
N8I86_RS10055	COG3830	Belongs to the UPF0237 family
N8I86_RS10055	COG0560	Phosphoserine phosphatase
N8I86_RS10080	COG2186	Transcriptional regulator
N8I86_RS10110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N8I86_RS10130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N8I86_RS10135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8I86_RS10150	COG1404	Belongs to the peptidase S8 family
N8I86_RS10155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8I86_RS10165	COG1063	alcohol dehydrogenase
N8I86_RS10200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N8I86_RS10215	COG3387	PFAM Glycoside hydrolase 15-related
N8I86_RS10245	COG1302	Protein conserved in bacteria
N8I86_RS10265	COG0488	(ABC) transporter
N8I86_RS10290	COG0235	Class ii aldolase
N8I86_RS10310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
N8I86_RS10315	COG1492	cobalamin metabolic process
N8I86_RS10335	COG1797	cobyrinic acid a,c-diamide synthase activity
N8I86_RS10395	COG0765	amino acid transport
N8I86_RS10400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8I86_RS10405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N8I86_RS10410	COG0456	acetyltransferase
N8I86_RS10415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N8I86_RS10420	COG1917	Cupin 2, conserved barrel domain protein
N8I86_RS10425	COG5285	phytanoyl-CoA dioxygenase
N8I86_RS10430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N8I86_RS10455	COG1414	Transcriptional regulator
N8I86_RS10465	COG0768	penicillin binding
N8I86_RS10470	COG2252	PERMEase
N8I86_RS10485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8I86_RS10490	COG1802	Transcriptional regulator
N8I86_RS10520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8I86_RS10525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8I86_RS10530	COG1349	DNA-binding transcription factor activity
N8I86_RS10545	COG0395	ABC-type sugar transport system, permease component
N8I86_RS10550	COG1063	alcohol dehydrogenase
N8I86_RS10610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8I86_RS10635	COG2171	N-acyltransferase activity
N8I86_RS10640	COG3226	Transcriptional regulator
N8I86_RS10645	COG2076	Multidrug Resistance protein
N8I86_RS10655	COG2151	metal-sulfur cluster biosynthetic enzyme
N8I86_RS10660	COG0822	iron-sulfur transferase activity
N8I86_RS10665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N8I86_RS10670	COG0396	ATPase activity
N8I86_RS10680	COG0719	Fe-S assembly protein
N8I86_RS10695	COG2746	aminoglycoside 3-N-acetyltransferase activity
N8I86_RS10700	COG1131	(ABC) transporter
N8I86_RS10730	COG0109	protoheme IX farnesyltransferase activity
N8I86_RS10740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N8I86_RS10755	COG0363	glucosamine-6-phosphate deaminase activity
N8I86_RS10770	COG0395	ABC-type sugar transport system, permease component
N8I86_RS10775	COG1175	transmembrane transport
N8I86_RS10780	COG1653	transport
N8I86_RS10785	COG0366	Alpha amylase catalytic
N8I86_RS10795	COG1695	Transcriptional regulator
N8I86_RS10800	COG1136	(ABC) transporter
N8I86_RS10815	COG0166	Belongs to the GPI family
N8I86_RS10830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N8I86_RS10835	COG0149	triose-phosphate isomerase activity
N8I86_RS10840	COG0126	phosphoglycerate kinase activity
N8I86_RS10845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N8I86_RS10855	COG1481	regulation of sporulation
N8I86_RS10860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N8I86_RS10865	COG1660	Displays ATPase and GTPase activities
N8I86_RS10870	COG0322	excinuclease ABC activity
N8I86_RS10885	COG1609	Transcriptional regulator
N8I86_RS10895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N8I86_RS10905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8I86_RS10910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8I86_RS10915	COG0765	amino acid transport
N8I86_RS10925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N8I86_RS10930	COG0477	Major facilitator Superfamily
N8I86_RS10935	COG0387	Pfam Sodium calcium exchanger
N8I86_RS10955	COG0556	nucleotide-excision repair
N8I86_RS10965	COG0584	glycerophosphoryl diester phosphodiesterase
N8I86_RS10970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N8I86_RS10980	COG2313	pseudouridylate synthase activity
N8I86_RS10985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N8I86_RS10985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N8I86_RS10990	COG2226	methyltransferase
N8I86_RS10995	COG0598	Magnesium transport protein CorA
N8I86_RS11020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS11025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8I86_RS11050	COG1132	(ABC) transporter
N8I86_RS11095	COG2226	methyltransferase
N8I86_RS11115	COG0237	dephospho-CoA kinase activity
N8I86_RS11130	COG0539	negative regulation of cytoplasmic translation
N8I86_RS11140	COG1643	Atp-dependent helicase
N8I86_RS11175	COG2050	protein possibly involved in aromatic compounds catabolism
N8I86_RS11235	COG0737	Belongs to the 5'-nucleotidase family
N8I86_RS11260	COG0287	Prephenate dehydrogenase
N8I86_RS11260	COG1605	Chorismate mutase
N8I86_RS11280	COG1846	Transcriptional regulator
N8I86_RS11285	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS11295	COG1024	Enoyl-CoA hydratase
N8I86_RS11315	COG0183	Belongs to the thiolase family
N8I86_RS11320	COG1309	transcriptional regulator
N8I86_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS11330	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS11340	COG2304	oxidoreductase activity
N8I86_RS11360	COG0067	glutamate synthase
N8I86_RS11360	COG0069	glutamate synthase activity
N8I86_RS11360	COG0070	glutamate synthase
N8I86_RS11390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8I86_RS11395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8I86_RS11405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N8I86_RS11415	COG0159	tryptophan synthase activity
N8I86_RS11420	COG0133	tryptophan synthase activity
N8I86_RS11430	COG0134	indole-3-glycerol-phosphate synthase activity
N8I86_RS11455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N8I86_RS11480	COG0107	imidazoleglycerol-phosphate synthase activity
N8I86_RS11485	COG0251	oxidation-reduction process
N8I86_RS11490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N8I86_RS11495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N8I86_RS11505	COG0131	Imidazoleglycerol-phosphate dehydratase
N8I86_RS11510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N8I86_RS11515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N8I86_RS11535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N8I86_RS11555	COG1432	Conserved Protein
N8I86_RS11565	COG0587	DNA-directed DNA polymerase activity
N8I86_RS11615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N8I86_RS11625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N8I86_RS11630	COG3599	regulation of cell shape
N8I86_RS11640	COG1799	cell septum assembly
N8I86_RS11650	COG1496	oxidoreductase activity
N8I86_RS11655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N8I86_RS11665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N8I86_RS11675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N8I86_RS11680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N8I86_RS11690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N8I86_RS11695	COG0768	penicillin binding
N8I86_RS11705	COG0275	rRNA processing
N8I86_RS11715	COG0714	Associated with various cellular activities
N8I86_RS11745	COG1121	(ABC) transporter
N8I86_RS11755	COG1309	transcriptional regulator
N8I86_RS11780	COG0352	thiamine-phosphate diphosphorylase activity
N8I86_RS11790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N8I86_RS11800	COG2022	thiamine diphosphate biosynthetic process
N8I86_RS11800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8I86_RS11815	COG2815	serine threonine protein kinase
N8I86_RS11815	COG0515	serine threonine protein kinase
N8I86_RS11820	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N8I86_RS11830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N8I86_RS11835	COG2193	ferroxidase activity
N8I86_RS11840	COG0243	molybdopterin cofactor binding
N8I86_RS11845	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N8I86_RS11855	COG0205	6-phosphofructokinase activity
N8I86_RS11865	COG4585	Histidine kinase
N8I86_RS11890	COG1940	carbohydrate kinase activity
N8I86_RS11900	COG0003	Pfam Anion-transporting ATPase
N8I86_RS11915	COG1022	Amp-dependent synthetase and ligase
N8I86_RS11925	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS11940	COG0791	NLP P60 protein
N8I86_RS11940	COG3883	PFAM NLP P60 protein
N8I86_RS11975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N8I86_RS11980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N8I86_RS11985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N8I86_RS11990	COG0723	plastoquinol--plastocyanin reductase activity
N8I86_RS11995	COG2010	Cytochrome c
N8I86_RS12000	COG1845	cytochrome c oxidase, subunit III
N8I86_RS12010	COG1376	ErfK ybiS ycfS ynhG family protein
N8I86_RS12020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8I86_RS12025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N8I86_RS12035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8I86_RS12055	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N8I86_RS12060	COG0515	serine threonine protein kinase
N8I86_RS12060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8I86_RS12065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8I86_RS12070	COG2197	response regulator
N8I86_RS12075	COG4585	Histidine kinase
N8I86_RS12100	COG2226	methyltransferase
N8I86_RS12120	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N8I86_RS12125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N8I86_RS12125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N8I86_RS12140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N8I86_RS12155	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS12165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N8I86_RS12170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8I86_RS12175	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8I86_RS12185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N8I86_RS12215	COG1090	epimerase
N8I86_RS12230	COG0321	lipoyl(octanoyl) transferase activity
N8I86_RS12235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N8I86_RS12270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8I86_RS12275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8I86_RS12305	COG0174	glutamine synthetase
N8I86_RS12320	COG0501	Belongs to the peptidase M48B family
N8I86_RS12375	COG0745	RESPONSE REGULATOR receiver
N8I86_RS12390	COG2197	response regulator
N8I86_RS12425	COG1309	transcriptional regulator
N8I86_RS12455	COG0366	Alpha amylase catalytic
N8I86_RS12460	COG3833	ABC-type maltose transport systems, permease component
N8I86_RS12465	COG1175	transmembrane transport
N8I86_RS12475	COG1609	Transcriptional regulator
N8I86_RS12485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N8I86_RS12500	COG3511	phospholipase C
N8I86_RS12535	COG3290	protein histidine kinase activity
N8I86_RS12540	COG0174	glutamine synthetase
N8I86_RS12560	COG2814	Major facilitator Superfamily
N8I86_RS12575	COG0477	Major facilitator Superfamily
N8I86_RS12580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N8I86_RS12605	COG1994	Peptidase M50
N8I86_RS12645	COG5398	heme oxygenase
N8I86_RS12655	COG0384	phenazine biosynthesis protein PhzF
N8I86_RS12670	COG0672	)-iron permease
N8I86_RS12695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N8I86_RS12700	COG2814	Major facilitator Superfamily
N8I86_RS12725	COG2259	Doxx family
N8I86_RS12775	COG0557	exoribonuclease II activity
N8I86_RS12780	COG3022	response to hydroperoxide
N8I86_RS12785	COG0800	Aldolase
N8I86_RS12800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N8I86_RS12815	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS12825	COG2030	dehydratase
N8I86_RS12835	COG2197	response regulator
N8I86_RS12855	COG0183	Belongs to the thiolase family
N8I86_RS12860	COG0477	Major facilitator Superfamily
N8I86_RS12880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS12905	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS12910	COG1309	transcriptional regulator
N8I86_RS12975	COG3619	membrane
N8I86_RS12980	COG2124	cytochrome p450
N8I86_RS12985	COG0183	Belongs to the thiolase family
N8I86_RS13015	COG4122	O-methyltransferase activity
N8I86_RS13055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N8I86_RS13120	COG1358	cellular component organization or biogenesis
N8I86_RS13165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N8I86_RS13170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8I86_RS13180	COG0477	Major facilitator Superfamily
N8I86_RS13185	COG1309	transcriptional regulator
N8I86_RS13200	COG0789	Transcriptional regulator
N8I86_RS13220	COG1741	Belongs to the pirin family
N8I86_RS13235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8I86_RS13240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8I86_RS13245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8I86_RS13290	COG2130	NADP-dependent
N8I86_RS13295	COG1764	response to oxidative stress
N8I86_RS13315	COG4948	Mandelate Racemase Muconate Lactonizing
N8I86_RS13340	COG4214	carbohydrate transport
N8I86_RS13350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N8I86_RS13380	COG3386	PFAM SMP-30 Gluconolaconase
N8I86_RS13385	COG1414	Transcriptional regulator
N8I86_RS13400	COG0583	DNA-binding transcription factor activity
N8I86_RS13425	COG1404	Belongs to the peptidase S8 family
N8I86_RS13450	COG1077	Cell shape determining protein MreB Mrl
N8I86_RS13510	COG0475	glutathione-regulated potassium exporter activity
N8I86_RS13550	COG1070	Carbohydrate kinase
N8I86_RS13580	COG0358	DNA primase activity
N8I86_RS13590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N8I86_RS13605	COG0243	molybdopterin cofactor binding
N8I86_RS13650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N8I86_RS13650	COG2146	nitrite reductase [NAD(P)H] activity
N8I86_RS13670	COG0574	Belongs to the PEP-utilizing enzyme family
N8I86_RS13670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N8I86_RS13675	COG1940	carbohydrate kinase activity
N8I86_RS13675	COG1846	Transcriptional regulator
N8I86_RS13680	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
N8I86_RS13710	COG0477	Major facilitator Superfamily
N8I86_RS13725	COG0667	Aldo Keto reductase
N8I86_RS13735	COG0423	glycine-tRNA ligase activity
N8I86_RS13745	COG1121	(ABC) transporter
N8I86_RS13750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N8I86_RS13765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N8I86_RS13770	COG1381	Involved in DNA repair and RecF pathway recombination
N8I86_RS13780	COG0747	negative chemotaxis
N8I86_RS13790	COG0444	Belongs to the ABC transporter superfamily
N8I86_RS13795	COG4608	Belongs to the ABC transporter superfamily
N8I86_RS13800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8I86_RS13810	COG2197	response regulator
N8I86_RS13815	COG4585	Histidine kinase
N8I86_RS13820	COG2409	Drug exporters of the RND superfamily
N8I86_RS13830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8I86_RS13860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N8I86_RS13900	COG2315	Protein conserved in bacteria
N8I86_RS13910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N8I86_RS13925	COG4948	Mandelate Racemase Muconate Lactonizing
N8I86_RS13930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8I86_RS13940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N8I86_RS13945	COG1234	tRNA 3'-trailer cleavage
N8I86_RS13950	COG0537	adenosine 5'-monophosphoramidase activity
N8I86_RS13955	COG4946	Tricorn protease homolog
N8I86_RS13955	COG0793	Belongs to the peptidase S41A family
N8I86_RS13980	COG0484	heat shock protein binding
N8I86_RS13985	COG1420	regulation of RNA biosynthetic process
N8I86_RS14015	COG0481	GTPase activity
N8I86_RS14020	COG0268	Binds directly to 16S ribosomal RNA
N8I86_RS14045	COG1555	photosystem II stabilization
N8I86_RS14050	COG1307	EDD domain protein, DegV family
N8I86_RS14060	COG0495	leucyl-tRNA aminoacylation
N8I86_RS14070	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N8I86_RS14100	COG0588	phosphoglycerate mutase activity
N8I86_RS14115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N8I86_RS14130	COG0501	Belongs to the peptidase M48B family
N8I86_RS14145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N8I86_RS14155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N8I86_RS14160	COG1215	transferase activity, transferring glycosyl groups
N8I86_RS14180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N8I86_RS14185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N8I86_RS14190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N8I86_RS14250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N8I86_RS14255	COG2326	polyphosphate kinase activity
N8I86_RS14285	COG2124	cytochrome p450
N8I86_RS14300	COG0477	Major facilitator Superfamily
N8I86_RS14320	COG1136	(ABC) transporter
N8I86_RS14320	COG0577	efflux transmembrane transporter activity
N8I86_RS14340	COG0772	Belongs to the SEDS family
N8I86_RS14345	COG0768	penicillin binding
N8I86_RS14360	COG1077	Cell shape determining protein MreB Mrl
N8I86_RS14365	COG0105	UTP biosynthetic process
N8I86_RS14375	COG0285	dihydrofolate synthase activity
N8I86_RS14380	COG0525	valine-tRNA ligase activity
N8I86_RS14390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N8I86_RS14395	COG0740	serine-type endopeptidase activity
N8I86_RS14400	COG0740	serine-type endopeptidase activity
N8I86_RS14405	COG0544	peptidyl-prolyl cis-trans isomerase activity
N8I86_RS14425	COG3594	Acyltransferase
N8I86_RS14440	COG4552	Acetyltransferase involved in intracellular survival and related
N8I86_RS14455	COG1113	amino acid transport
N8I86_RS14465	COG1940	carbohydrate kinase activity
N8I86_RS14470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8I86_RS14475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8I86_RS14480	COG1116	anion transmembrane transporter activity
N8I86_RS14485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS14495	COG1113	amino acid transport
N8I86_RS14500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N8I86_RS14505	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N8I86_RS14520	COG2318	DinB family
N8I86_RS14595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8I86_RS14620	COG1595	DNA-templated transcription, initiation
N8I86_RS14630	COG1131	(ABC) transporter
N8I86_RS14650	COG0668	transmembrane transport
N8I86_RS14665	COG1940	carbohydrate kinase activity
N8I86_RS14670	COG1653	transport
N8I86_RS14675	COG1175	transmembrane transport
N8I86_RS14680	COG0395	ABC-type sugar transport system, permease component
N8I86_RS14685	COG1486	melibiose metabolic process
N8I86_RS14700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8I86_RS14730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N8I86_RS14750	COG1136	(ABC) transporter
N8I86_RS14770	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N8I86_RS14800	COG0629	single-stranded DNA binding
N8I86_RS14805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N8I86_RS14855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8I86_RS14910	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS14915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N8I86_RS14990	COG1131	(ABC) transporter
N8I86_RS15005	COG3962	Belongs to the TPP enzyme family
N8I86_RS15010	COG3718	enzyme involved in inositol metabolism
N8I86_RS15020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8I86_RS15040	COG2409	Drug exporters of the RND superfamily
N8I86_RS15070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N8I86_RS15110	COG1129	ABC transporter
N8I86_RS15120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8I86_RS15125	COG1869	D-ribose catabolic process
N8I86_RS15140	COG0673	inositol 2-dehydrogenase activity
N8I86_RS15145	COG1609	Transcriptional regulator
N8I86_RS15150	COG1846	Transcriptional regulator
N8I86_RS15150	COG0456	acetyltransferase
N8I86_RS15165	COG1472	Belongs to the glycosyl hydrolase 3 family
N8I86_RS15210	COG0028	Belongs to the TPP enzyme family
N8I86_RS15220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8I86_RS15245	COG1946	Acyl-CoA thioesterase
N8I86_RS15260	COG1309	transcriptional regulator
N8I86_RS15265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N8I86_RS15275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8I86_RS15280	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS15300	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N8I86_RS15335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N8I86_RS15345	COG0589	response to stress
N8I86_RS15355	COG4977	sequence-specific DNA binding
N8I86_RS15360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N8I86_RS15395	COG3979	chitinase
N8I86_RS15405	COG0745	RESPONSE REGULATOR receiver
N8I86_RS15415	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N8I86_RS15430	COG0406	alpha-ribazole phosphatase activity
N8I86_RS15485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS15505	COG0154	amidase activity
N8I86_RS15515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8I86_RS15520	COG0765	amino acid transport
N8I86_RS15525	COG0765	amino acid transport
N8I86_RS15530	COG1126	abc transporter atp-binding protein
N8I86_RS15545	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS15555	COG3397	chitin binding
N8I86_RS15575	COG2186	Transcriptional regulator
N8I86_RS15640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8I86_RS15645	COG2188	Transcriptional regulator
N8I86_RS15665	COG0673	inositol 2-dehydrogenase activity
N8I86_RS15670	COG4702	Belongs to the UPF0303 family
N8I86_RS15685	COG0706	membrane insertase activity
N8I86_RS15695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N8I86_RS15710	COG3764	Sortase (surface protein transpeptidase)
N8I86_RS15760	COG2733	membrane
N8I86_RS15770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N8I86_RS15825	COG4555	ABC transporter
N8I86_RS15840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N8I86_RS15845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N8I86_RS15850	COG1263	PTS System
N8I86_RS15855	COG1263	PTS System
N8I86_RS15860	COG1234	tRNA 3'-trailer cleavage
N8I86_RS15895	COG1113	amino acid transport
N8I86_RS15910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N8I86_RS15920	COG1335	isochorismatase
N8I86_RS15955	COG0277	FAD linked oxidase domain protein
N8I86_RS15965	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N8I86_RS15975	COG1174	glycine betaine transport
N8I86_RS15985	COG1174	glycine betaine transport
N8I86_RS16115	COG1584	GPR1 FUN34 yaaH family protein
N8I86_RS16145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
N8I86_RS16155	COG1678	Uncharacterized ACR, COG1678
N8I86_RS16160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N8I86_RS16165	COG0776	regulation of translation
N8I86_RS16175	COG3973	AAA domain
N8I86_RS16205	COG2223	nitrite transmembrane transporter activity
N8I86_RS16225	COG0583	DNA-binding transcription factor activity
N8I86_RS16245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N8I86_RS16250	COG0793	Belongs to the peptidase S41A family
N8I86_RS16255	COG2177	Part of the ABC transporter FtsEX involved in
N8I86_RS16260	COG2884	Cell division ATP-binding protein ftsE
N8I86_RS16275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N8I86_RS16285	COG0515	serine threonine protein kinase
N8I86_RS16290	COG1674	ftsk spoiiie
N8I86_RS16300	COG1175	transmembrane transport
N8I86_RS16305	COG0395	ABC-type sugar transport system, permease component
N8I86_RS16310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N8I86_RS16310	COG0463	Glycosyl transferase, family 2
N8I86_RS16315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N8I86_RS16320	COG1216	Glycosyl transferase, family 2
N8I86_RS16320	COG1442	glycosyl transferase family 8
N8I86_RS16325	COG1764	response to oxidative stress
N8I86_RS16330	COG1846	Transcriptional regulator
N8I86_RS16345	COG1215	transferase activity, transferring glycosyl groups
N8I86_RS16365	COG1134	teichoic acid transport
N8I86_RS16370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N8I86_RS16375	COG1215	transferase activity, transferring glycosyl groups
N8I86_RS16385	COG2902	Dehydrogenase
N8I86_RS16410	COG0653	protein targeting
N8I86_RS16420	COG3214	Protein conserved in bacteria
N8I86_RS16425	COG2197	response regulator
N8I86_RS16430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N8I86_RS16440	COG0823	Involved in the tonB-independent uptake of proteins
N8I86_RS16445	COG5000	phosphorelay sensor kinase activity
N8I86_RS16445	COG5002	protein histidine kinase activity
N8I86_RS16450	COG0745	RESPONSE REGULATOR receiver
N8I86_RS16475	COG0714	Associated with various cellular activities
N8I86_RS16515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N8I86_RS16540	COG2835	tetraacyldisaccharide 4'-kinase activity
N8I86_RS16580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N8I86_RS16585	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
N8I86_RS16585	COG0778	Nitroreductase
N8I86_RS16610	COG1316	TRANSCRIPTIONal
N8I86_RS16620	COG1316	TRANSCRIPTIONal
N8I86_RS16630	COG1316	TRANSCRIPTIONal
N8I86_RS16635	COG1316	TRANSCRIPTIONal
N8I86_RS16645	COG1316	TRANSCRIPTIONal
N8I86_RS16665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N8I86_RS16680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N8I86_RS16695	COG2205	protein histidine kinase activity
N8I86_RS16700	COG0745	RESPONSE REGULATOR receiver
N8I86_RS16705	COG3104	oligopeptide transport
N8I86_RS16735	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS16740	COG1191	sigma factor activity
N8I86_RS16750	COG1228	amidohydrolase
N8I86_RS16760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8I86_RS16765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N8I86_RS16810	COG4221	oxidoreductase activity
N8I86_RS16820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N8I86_RS16825	COG1072	(Pantothenic acid kinase))
N8I86_RS16830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N8I86_RS16835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N8I86_RS16840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N8I86_RS16850	COG0101	tRNA pseudouridine synthase activity
N8I86_RS16855	COG0203	ribosomal protein L17
N8I86_RS16860	COG0202	RNA polymerase activity
N8I86_RS16865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N8I86_RS16870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N8I86_RS16875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N8I86_RS16880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N8I86_RS16890	COG0563	adenylate kinase activity
N8I86_RS16900	COG0200	Binds to the 23S rRNA
N8I86_RS16905	COG1841	ribosomal large subunit assembly
N8I86_RS16910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N8I86_RS16915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N8I86_RS16920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N8I86_RS16925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N8I86_RS16930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N8I86_RS16935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N8I86_RS16940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N8I86_RS16945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N8I86_RS16950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N8I86_RS16955	COG0255	Belongs to the universal ribosomal protein uL29 family
N8I86_RS16960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N8I86_RS16965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N8I86_RS16970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N8I86_RS16975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N8I86_RS16980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N8I86_RS16985	COG0089	rRNA binding
N8I86_RS16990	COG0088	Forms part of the polypeptide exit tunnel
N8I86_RS16995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N8I86_RS17000	COG0051	transcription antitermination factor activity, RNA binding
N8I86_RS17025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N8I86_RS17030	COG0049	tRNA binding
N8I86_RS17035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N8I86_RS17070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N8I86_RS17075	COG0085	RNA polymerase activity
N8I86_RS17080	COG0222	ribosome binding
N8I86_RS17085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N8I86_RS17095	COG0081	regulation of translation
N8I86_RS17100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N8I86_RS17105	COG0250	Participates in transcription elongation, termination and antitermination
N8I86_RS17120	COG0436	Aminotransferase
N8I86_RS17125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N8I86_RS17130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N8I86_RS17140	COG0477	Major facilitator Superfamily
N8I86_RS17155	COG2030	dehydratase
N8I86_RS17160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N8I86_RS17180	COG0702	epimerase
N8I86_RS17205	COG1666	GTP binding
N8I86_RS17210	COG2261	transglycosylase associated protein
N8I86_RS17220	COG3304	Inner membrane component domain
N8I86_RS17225	COG0501	Belongs to the peptidase M48B family
N8I86_RS17230	COG1007	ATP synthesis coupled electron transport
N8I86_RS17245	COG0713	ATP synthesis coupled electron transport
N8I86_RS17250	COG0839	Belongs to the complex I subunit 6 family
N8I86_RS17255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8I86_RS17260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N8I86_RS17270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8I86_RS17275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8I86_RS17295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N8I86_RS17295	COG0674	pyruvate-flavodoxin oxidoreductase activity
N8I86_RS17300	COG1013	pyruvate-flavodoxin oxidoreductase activity
N8I86_RS17305	COG1733	regulation of RNA biosynthetic process
N8I86_RS17310	COG0702	epimerase
N8I86_RS17350	COG0142	geranyltranstransferase activity
N8I86_RS17355	COG3953	SLT domain
N8I86_RS17355	COG5412	phage tail tape measure protein
N8I86_RS17360	COG0561	phosphatase activity
N8I86_RS17380	COG2188	Transcriptional regulator
N8I86_RS17400	COG1116	anion transmembrane transporter activity
N8I86_RS17400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8I86_RS17405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N8I86_RS17410	COG0514	ATP-dependent DNA helicase (RecQ)
N8I86_RS17415	COG1007	ATP synthesis coupled electron transport
N8I86_RS17425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N8I86_RS17430	COG0713	ATP synthesis coupled electron transport
N8I86_RS17435	COG0839	Belongs to the complex I subunit 6 family
N8I86_RS17440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8I86_RS17445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N8I86_RS17450	COG1034	ATP synthesis coupled electron transport
N8I86_RS17455	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N8I86_RS17465	COG0649	NAD binding
N8I86_RS17470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8I86_RS17475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8I86_RS17505	COG2226	methyltransferase
N8I86_RS17520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N8I86_RS17535	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N8I86_RS17540	COG1278	Cold shock
N8I86_RS17565	COG2226	methyltransferase
N8I86_RS17600	COG1309	transcriptional regulator
N8I86_RS17615	COG1573	uracil-dna glycosylase
N8I86_RS17620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N8I86_RS17630	COG0163	prenyltransferase activity
N8I86_RS17640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N8I86_RS17645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8I86_RS17680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N8I86_RS17685	COG1333	cytochrome c biogenesis protein
N8I86_RS17690	COG0785	Cytochrome C biogenesis protein
N8I86_RS17705	COG0406	alpha-ribazole phosphatase activity
N8I86_RS17710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N8I86_RS17750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N8I86_RS17750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N8I86_RS17755	COG2205	protein histidine kinase activity
N8I86_RS17770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS17775	COG0604	alcohol dehydrogenase
N8I86_RS17780	COG1733	regulation of RNA biosynthetic process
N8I86_RS17790	COG1742	UPF0060 membrane protein
N8I86_RS17805	COG1690	Belongs to the RtcB family
N8I86_RS17825	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
N8I86_RS17830	COG0018	arginyl-trna synthetase
N8I86_RS17840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8I86_RS17850	COG0113	porphobilinogen synthase activity
N8I86_RS17860	COG1648	precorrin-2 dehydrogenase activity
N8I86_RS17860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N8I86_RS17865	COG0181	hydroxymethylbilane synthase activity
N8I86_RS17870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N8I86_RS17875	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N8I86_RS17925	COG0123	including yeast histone deacetylase and acetoin utilization protein
N8I86_RS17930	COG2223	nitrite transmembrane transporter activity
N8I86_RS17940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N8I86_RS17960	COG0180	Tryptophanyl-tRNA synthetase
N8I86_RS17965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N8I86_RS17975	COG0842	Transport permease protein
N8I86_RS17975	COG1129	ABC transporter
N8I86_RS17990	COG4991	sh3 domain protein
N8I86_RS18000	COG0129	dihydroxy-acid dehydratase activity
N8I86_RS18010	COG1082	Xylose isomerase domain protein TIM barrel
N8I86_RS18015	COG0248	Ppx GppA phosphatase
N8I86_RS18035	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
N8I86_RS18045	COG1194	a g-specific adenine glycosylase
N8I86_RS18050	COG1595	DNA-templated transcription, initiation
N8I86_RS18060	COG0745	RESPONSE REGULATOR receiver
N8I86_RS18065	COG2205	protein histidine kinase activity
N8I86_RS18080	COG0739	heme binding
N8I86_RS18105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N8I86_RS18125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N8I86_RS18135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N8I86_RS18140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N8I86_RS18165	COG2197	response regulator
N8I86_RS18180	COG0649	NAD binding
N8I86_RS18205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N8I86_RS18205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N8I86_RS18220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N8I86_RS18235	COG0302	gtp cyclohydrolase
N8I86_RS18250	COG0037	tRNA processing
N8I86_RS18260	COG2027	D-alanyl-D-alanine carboxypeptidase
N8I86_RS18265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N8I86_RS18280	COG0393	Putative heavy-metal-binding
N8I86_RS18285	COG0789	Transcriptional regulator
N8I86_RS18295	COG0076	glutamate decarboxylase activity
N8I86_RS18305	COG2318	DinB family
N8I86_RS18310	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS18365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N8I86_RS18365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N8I86_RS18400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N8I86_RS18400	COG1754	DNA topoisomerase type I activity
N8I86_RS18420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
N8I86_RS18430	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS18435	COG1111	helicase
N8I86_RS18435	COG1205	dead DEAH box helicase
N8I86_RS18500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N8I86_RS18515	COG2267	carboxylic ester hydrolase activity
N8I86_RS18545	COG0737	Belongs to the 5'-nucleotidase family
N8I86_RS18550	COG0456	acetyltransferase
N8I86_RS18555	COG1725	Transcriptional regulator
N8I86_RS18560	COG3842	ATPase activity
N8I86_RS18575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N8I86_RS18585	COG0494	nUDIX hydrolase
N8I86_RS18585	COG0406	alpha-ribazole phosphatase activity
N8I86_RS18605	COG1937	Protein conserved in bacteria
N8I86_RS18615	COG0306	phosphate transporter
N8I86_RS18620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N8I86_RS18640	COG0277	FAD linked oxidase domain protein
N8I86_RS18645	COG0671	phosphoesterase, PA-phosphatase related
N8I86_RS18660	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS18700	COG0456	acetyltransferase
N8I86_RS18740	COG1252	NADH dehydrogenase
N8I86_RS18770	COG0579	oxidoreductase
N8I86_RS18775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N8I86_RS18800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N8I86_RS18800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N8I86_RS18810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N8I86_RS18830	COG0513	Belongs to the DEAD box helicase family
N8I86_RS18875	COG1643	Atp-dependent helicase
N8I86_RS18910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N8I86_RS18930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N8I86_RS18935	COG0047	phosphoribosylformylglycinamidine synthase activity
N8I86_RS18940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N8I86_RS18970	COG3851	Histidine kinase
N8I86_RS18975	COG2197	response regulator
N8I86_RS18985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N8I86_RS19000	COG0151	Belongs to the GarS family
N8I86_RS19045	COG1276	copper resistance
N8I86_RS19045	COG2372	response to copper ion
N8I86_RS19085	COG0433	COG0433 Predicted ATPase
N8I86_RS19100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N8I86_RS19135	COG1191	sigma factor activity
N8I86_RS19140	COG1191	sigma factor activity
N8I86_RS19165	COG2353	YceI-like domain
N8I86_RS19175	COG3467	pyridoxamine 5'-phosphate
N8I86_RS19185	COG0477	Major facilitator Superfamily
N8I86_RS19190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N8I86_RS19200	COG2205	protein histidine kinase activity
N8I86_RS19205	COG0745	RESPONSE REGULATOR receiver
N8I86_RS19220	COG1846	Transcriptional regulator
N8I86_RS19245	COG2814	Major facilitator Superfamily
N8I86_RS19250	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS19255	COG1595	DNA-templated transcription, initiation
N8I86_RS19280	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS19315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8I86_RS19330	COG0653	protein targeting
N8I86_RS19350	COG0006	proline dipeptidase activity
N8I86_RS19400	COG2837	iron assimilation
N8I86_RS19410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N8I86_RS19415	COG0561	phosphatase activity
N8I86_RS19445	COG1131	(ABC) transporter
N8I86_RS19460	COG0789	Transcriptional regulator
N8I86_RS19465	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
N8I86_RS19480	COG0561	phosphatase activity
N8I86_RS19485	COG4988	ABC transporter
N8I86_RS19490	COG1294	oxidase, subunit
N8I86_RS19495	COG1271	oxidase subunit
N8I86_RS19505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N8I86_RS19510	COG1609	Transcriptional regulator
N8I86_RS19530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N8I86_RS19555	COG0662	Cupin 2, conserved barrel domain protein
N8I86_RS19560	COG1950	PFAM Membrane protein of
N8I86_RS19565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N8I86_RS19570	COG0626	cystathionine gamma-synthase activity
N8I86_RS19605	COG2814	Major facilitator Superfamily
N8I86_RS19625	COG0305	Participates in initiation and elongation during chromosome replication
N8I86_RS19635	COG0359	binds to the 23S rRNA
N8I86_RS19640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N8I86_RS19645	COG0629	single-stranded DNA binding
N8I86_RS19650	COG0360	Binds together with S18 to 16S ribosomal RNA
N8I86_RS19675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N8I86_RS19695	COG0617	tRNA 3'-terminal CCA addition
N8I86_RS19710	COG0515	serine threonine protein kinase
N8I86_RS19710	COG2815	serine threonine protein kinase
N8I86_RS19715	COG1595	DNA-templated transcription, initiation
N8I86_RS19725	COG0492	ferredoxin-NADP+ reductase activity
N8I86_RS19730	COG3118	belongs to the thioredoxin family
N8I86_RS19745	COG1192	Involved in chromosome partitioning
N8I86_RS19750	COG0357	Ribosomal RNA small subunit methyltransferase G
N8I86_RS19760	COG0706	membrane insertase activity
N8I86_RS19765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N8I86_RS19770	COG0594	ribonuclease P activity
N8I86_RS19775	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N8I86_RS19780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N8I86_RS19785	COG0592	DNA-directed DNA polymerase activity
N8I86_RS19790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N8I86_RS19795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N8I86_RS19800	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
N8I86_RS19805	COG0187	DNA topoisomerase II activity
N8I86_RS19810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N8I86_RS19870	COG0515	serine threonine protein kinase
N8I86_RS19895	COG0705	Rhomboid family
N8I86_RS19910	COG3764	Sortase (surface protein transpeptidase)
N8I86_RS19925	COG3764	Sortase (surface protein transpeptidase)
N8I86_RS19930	COG3764	Sortase (surface protein transpeptidase)
N8I86_RS19935	COG0515	serine threonine protein kinase
N8I86_RS19940	COG0768	penicillin binding
N8I86_RS20010	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8I86_RS20015	COG1309	transcriptional regulator
N8I86_RS20020	COG1522	sequence-specific DNA binding
N8I86_RS20040	COG0746	molybdenum cofactor guanylyltransferase activity
N8I86_RS20050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N8I86_RS20055	COG3321	synthase
N8I86_RS20055	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS20055	COG0604	alcohol dehydrogenase
N8I86_RS20070	COG0515	serine threonine protein kinase
N8I86_RS20075	COG0515	serine threonine protein kinase
N8I86_RS20080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N8I86_RS20090	COG0022	dehydrogenase e1 component
N8I86_RS20095	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8I86_RS20120	COG2814	Major facilitator Superfamily
N8I86_RS20160	COG1362	aminopeptidase activity
N8I86_RS20165	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS20175	COG1741	Belongs to the pirin family
N8I86_RS20190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N8I86_RS20210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8I86_RS20220	COG1289	transmembrane transporter activity
N8I86_RS20235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8I86_RS20295	COG0366	Alpha amylase catalytic
N8I86_RS20325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N8I86_RS20365	COG1595	DNA-templated transcription, initiation
N8I86_RS20395	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
N8I86_RS20410	COG0717	Belongs to the dCTP deaminase family
N8I86_RS20415	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N8I86_RS20445	COG0247	lactate metabolic process
N8I86_RS20445	COG2181	nitrate reductase activity
N8I86_RS20450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N8I86_RS20455	COG0443	Heat shock 70 kDa protein
N8I86_RS20460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N8I86_RS20465	COG0484	heat shock protein binding
N8I86_RS20470	COG0789	Transcriptional regulator
N8I86_RS20475	COG4213	ABC transporter substrate-binding protein
N8I86_RS20510	COG0542	response to heat
N8I86_RS20560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N8I86_RS20580	COG3483	tryptophan 2,3-dioxygenase activity
N8I86_RS20585	COG3844	kynureninase activity
N8I86_RS20605	COG4585	Histidine kinase
N8I86_RS20610	COG2197	response regulator
N8I86_RS20615	COG4585	Histidine kinase
N8I86_RS20620	COG2197	response regulator
N8I86_RS20635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N8I86_RS20650	COG1802	Transcriptional regulator
N8I86_RS20655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N8I86_RS20670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N8I86_RS20675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N8I86_RS20725	COG0701	Predicted permease
N8I86_RS20770	COG0072	phenylalanine-tRNA ligase activity
N8I86_RS20770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8I86_RS20835	COG1408	metallophosphoesterase
N8I86_RS20855	COG0003	Pfam Anion-transporting ATPase
N8I86_RS20880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8I86_RS20900	COG1846	Transcriptional regulator
N8I86_RS20910	COG0745	RESPONSE REGULATOR receiver
N8I86_RS20920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8I86_RS20925	COG1609	Transcriptional regulator
N8I86_RS20930	COG0745	RESPONSE REGULATOR receiver
N8I86_RS20955	COG2897	thiosulfate sulfurtransferase activity
N8I86_RS20975	COG3485	protocatechuate 3,4-dioxygenase
N8I86_RS20980	COG0735	belongs to the Fur family
N8I86_RS20985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N8I86_RS20990	COG1490	D-aminoacyl-tRNA deacylase activity
N8I86_RS21000	COG4552	Acetyltransferase involved in intracellular survival and related
N8I86_RS21005	COG2188	Transcriptional regulator
N8I86_RS21015	COG2186	Transcriptional regulator
N8I86_RS21020	COG0546	phosphoglycolate phosphatase activity
N8I86_RS21030	COG1309	transcriptional regulator
N8I86_RS21045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N8I86_RS21080	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS21105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS21115	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS21120	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS21125	COG0588	phosphoglycerate mutase activity
N8I86_RS21140	COG2188	Transcriptional regulator
N8I86_RS21220	COG5002	protein histidine kinase activity
N8I86_RS21235	COG1329	Transcriptional regulator
N8I86_RS21240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N8I86_RS21245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N8I86_RS21255	COG0215	cysteine-tRNA ligase activity
N8I86_RS21260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N8I86_RS21280	COG3842	ATPase activity
N8I86_RS21330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N8I86_RS21350	COG3300	MHYT domain
N8I86_RS21350	COG5001	Diguanylate cyclase
N8I86_RS21400	COG0463	Glycosyl transferase, family 2
N8I86_RS21415	COG1278	Cold shock
N8I86_RS21420	COG0459	protein refolding
N8I86_RS21435	COG1263	PTS System
N8I86_RS21435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N8I86_RS21440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N8I86_RS21445	COG1737	Transcriptional regulator
N8I86_RS21475	COG3973	AAA domain
N8I86_RS21495	COG1061	Type III restriction enzyme res subunit
N8I86_RS21530	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N8I86_RS21535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N8I86_RS21545	COG2814	Major facilitator Superfamily
N8I86_RS21580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N8I86_RS21590	COG2252	PERMEase
N8I86_RS21620	COG0667	Aldo Keto reductase
N8I86_RS21640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N8I86_RS21645	COG0277	FAD linked oxidase domain protein
N8I86_RS21645	COG0247	lactate metabolic process
N8I86_RS21660	COG5006	permease, DMT superfamily
N8I86_RS21680	COG0281	malic enzyme
N8I86_RS21695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N8I86_RS21710	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS21735	COG0259	pyridoxamine-phosphate oxidase activity
N8I86_RS21750	COG4821	SIS domain
N8I86_RS21760	COG0596	Alpha beta hydrolase
N8I86_RS21760	COG2945	thiolester hydrolase activity
N8I86_RS21830	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS21840	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS21845	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS21860	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS21865	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS21890	COG1024	Enoyl-CoA hydratase
N8I86_RS21900	COG2072	flavoprotein involved in K transport
N8I86_RS21945	COG1280	lysine exporter protein (LysE YggA)
N8I86_RS21950	COG1522	sequence-specific DNA binding
N8I86_RS21955	COG1309	transcriptional regulator
N8I86_RS21975	COG1024	Enoyl-CoA hydratase
N8I86_RS21990	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS22000	COG3629	intracellular signal transduction
N8I86_RS22000	COG3903	Transcriptional regulator
N8I86_RS22030	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS22080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N8I86_RS22105	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS22145	COG0386	Belongs to the glutathione peroxidase family
N8I86_RS22160	COG0330	HflC and HflK could
N8I86_RS22205	COG2268	Band 7 protein
N8I86_RS22230	COG2329	Antibiotic biosynthesis monooxygenase
N8I86_RS22270	COG1846	Transcriptional regulator
N8I86_RS22275	COG3384	dioxygenase
N8I86_RS22295	COG0477	Major facilitator Superfamily
N8I86_RS22300	COG1349	DNA-binding transcription factor activity
N8I86_RS22325	COG1376	ErfK ybiS ycfS ynhG family protein
N8I86_RS22330	COG3191	aminopeptidase activity
N8I86_RS22340	COG1970	mechanosensitive ion channel activity
N8I86_RS22350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N8I86_RS22360	COG0477	Major facilitator Superfamily
N8I86_RS22365	COG3263	regulation of cellular component size
N8I86_RS22375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N8I86_RS22380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N8I86_RS22390	COG0315	cyclic pyranopterin monophosphate synthase activity
N8I86_RS22395	COG0521	Mo-molybdopterin cofactor biosynthetic process
N8I86_RS22395	COG0315	cyclic pyranopterin monophosphate synthase activity
N8I86_RS22400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N8I86_RS22415	COG0454	-acetyltransferase
N8I86_RS22420	COG0708	Exodeoxyribonuclease III
N8I86_RS22425	COG0789	Transcriptional regulator
N8I86_RS22430	COG2072	flavoprotein involved in K transport
N8I86_RS22435	COG2267	carboxylic ester hydrolase activity
N8I86_RS22440	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS22450	COG4946	Tricorn protease homolog
N8I86_RS22450	COG0793	Belongs to the peptidase S41A family
N8I86_RS22460	COG2409	Drug exporters of the RND superfamily
N8I86_RS22465	COG0442	prolyl-tRNA aminoacylation
N8I86_RS22490	COG1764	response to oxidative stress
N8I86_RS22495	COG1846	Transcriptional regulator
N8I86_RS22500	COG1122	ATPase activity
N8I86_RS22510	COG0310	cobalt ion transport
N8I86_RS22520	COG0768	penicillin binding
N8I86_RS22525	COG0768	penicillin binding
N8I86_RS22550	COG0084	hydrolase, TatD family'
N8I86_RS22560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N8I86_RS22565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N8I86_RS22570	COG0488	(ABC) transporter
N8I86_RS22610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N8I86_RS22645	COG2197	response regulator
N8I86_RS22655	COG4106	trans-aconitate 2-methyltransferase activity
N8I86_RS22665	COG1309	transcriptional regulator
N8I86_RS22675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N8I86_RS22685	COG0193	aminoacyl-tRNA hydrolase activity
N8I86_RS22690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N8I86_RS22695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N8I86_RS22700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N8I86_RS22715	COG4585	Histidine kinase
N8I86_RS22755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8I86_RS22765	COG0477	Major facilitator Superfamily
N8I86_RS22770	COG1136	(ABC) transporter
N8I86_RS22775	COG0577	efflux transmembrane transporter activity
N8I86_RS22840	COG2124	cytochrome p450
N8I86_RS22855	COG0148	phosphopyruvate hydratase activity
N8I86_RS22875	COG1252	NADH dehydrogenase
N8I86_RS22885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N8I86_RS22890	COG0577	efflux transmembrane transporter activity
N8I86_RS22895	COG1136	(ABC) transporter
N8I86_RS22930	COG0183	Belongs to the thiolase family
N8I86_RS22935	COG2755	lipolytic protein G-D-S-L family
N8I86_RS22945	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS22950	COG0736	holo-[acyl-carrier-protein] synthase activity
N8I86_RS22960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N8I86_RS22970	COG0802	atpase or kinase
N8I86_RS22995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N8I86_RS23005	COG1472	Belongs to the glycosyl hydrolase 3 family
N8I86_RS23010	COG1609	Transcriptional regulator
N8I86_RS23025	COG4941	Belongs to the sigma-70 factor family
N8I86_RS23035	COG0726	polysaccharide deacetylase
N8I86_RS23040	COG0726	polysaccharide deacetylase
N8I86_RS23045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N8I86_RS23050	COG0459	protein refolding
N8I86_RS23060	COG4221	oxidoreductase activity
N8I86_RS23070	COG0583	DNA-binding transcription factor activity
N8I86_RS23085	COG1595	DNA-templated transcription, initiation
N8I86_RS23095	COG0516	GMP reductase activity
N8I86_RS23110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N8I86_RS23115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N8I86_RS23125	COG2815	serine threonine protein kinase
N8I86_RS23125	COG0515	serine threonine protein kinase
N8I86_RS23140	COG0515	serine threonine protein kinase
N8I86_RS23140	COG2815	serine threonine protein kinase
N8I86_RS23155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8I86_RS23160	COG0515	serine threonine protein kinase
N8I86_RS23165	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS23180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N8I86_RS23180	COG0519	Catalyzes the synthesis of GMP from XMP
N8I86_RS23220	COG2197	response regulator
N8I86_RS23260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS23260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS23275	COG0714	Associated with various cellular activities
N8I86_RS23285	COG3552	Protein containing von Willebrand factor type A (VWA) domain
N8I86_RS23295	COG0045	succinate-CoA ligase (ADP-forming) activity
N8I86_RS23325	COG0138	bifunctional purine biosynthesis protein purh
N8I86_RS23340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N8I86_RS23355	COG0039	L-malate dehydrogenase activity
N8I86_RS23360	COG0477	Major facilitator Superfamily
N8I86_RS23385	COG4175	Glycine betaine
N8I86_RS23385	COG0517	IMP dehydrogenase activity
N8I86_RS23390	COG4176	ABC-type proline glycine betaine transport system permease component
N8I86_RS23405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS23425	COG0754	glutathionylspermidine amidase activity
N8I86_RS23440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N8I86_RS23445	COG0180	Tryptophanyl-tRNA synthetase
N8I86_RS23465	COG1295	ribonuclease BN
N8I86_RS23480	COG1408	metallophosphoesterase
N8I86_RS23490	COG1309	transcriptional regulator
N8I86_RS23520	COG1053	succinate dehydrogenase
N8I86_RS23530	COG2009	succinate dehydrogenase
N8I86_RS23540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
N8I86_RS23580	COG1595	DNA-templated transcription, initiation
N8I86_RS23595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS23595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS23640	COG1216	Glycosyl transferase, family 2
N8I86_RS23655	COG2089	acid synthase
N8I86_RS23670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N8I86_RS23670	COG1473	amidohydrolase
N8I86_RS23675	COG1744	ABC transporter substrate-binding protein PnrA-like
N8I86_RS23680	COG3845	ABC transporter
N8I86_RS23685	COG4603	Belongs to the binding-protein-dependent transport system permease family
N8I86_RS23690	COG1079	Belongs to the binding-protein-dependent transport system permease family
N8I86_RS23720	COG2814	Major facilitator Superfamily
N8I86_RS23725	COG0583	DNA-binding transcription factor activity
N8I86_RS23735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N8I86_RS23760	COG2205	protein histidine kinase activity
N8I86_RS23765	COG0745	RESPONSE REGULATOR receiver
N8I86_RS23770	COG1595	DNA-templated transcription, initiation
N8I86_RS23785	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS23790	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS23795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N8I86_RS23805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N8I86_RS23830	COG4770	biotin carboxylase activity
N8I86_RS23840	COG0424	maF-like protein
N8I86_RS23855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N8I86_RS23865	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
N8I86_RS23875	COG1024	Enoyl-CoA hydratase
N8I86_RS23885	COG2986	histidine ammonia-lyase
N8I86_RS23915	COG1136	(ABC) transporter
N8I86_RS23920	COG1404	Belongs to the peptidase S8 family
N8I86_RS23930	COG1064	alcohol dehydrogenase
N8I86_RS23950	COG3265	gluconokinase activity
N8I86_RS23990	COG2255	four-way junction helicase activity
N8I86_RS23995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N8I86_RS24010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N8I86_RS24020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N8I86_RS24040	COG1331	Highly conserved protein containing a thioredoxin domain
N8I86_RS24090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N8I86_RS24120	COG0436	Aminotransferase
N8I86_RS24135	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N8I86_RS24150	COG1414	Transcriptional regulator
N8I86_RS24155	COG0251	oxidation-reduction process
N8I86_RS24160	COG2610	gluconate transmembrane transporter activity
N8I86_RS24230	COG2894	cell division
N8I86_RS24260	COG3920	Histidine kinase
N8I86_RS24265	COG2197	response regulator
N8I86_RS24285	COG2885	chlorophyll binding
N8I86_RS24310	COG2318	DinB family
N8I86_RS24320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N8I86_RS24325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N8I86_RS24330	COG0741	lytic transglycosylase activity
N8I86_RS24340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS24345	COG0450	alkyl hydroperoxide reductase
N8I86_RS24360	COG1136	(ABC) transporter
N8I86_RS24380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N8I86_RS24380	COG4499	WXG100 protein secretion system (Wss), protein YukC
N8I86_RS24395	COG0114	fumarate hydratase activity
N8I86_RS24405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N8I86_RS24405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N8I86_RS24430	COG0778	Nitroreductase
N8I86_RS24435	COG1722	exodeoxyribonuclease VII activity
N8I86_RS24440	COG1570	exodeoxyribonuclease VII activity
N8I86_RS24445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N8I86_RS24460	COG0012	GTP binding
N8I86_RS24525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N8I86_RS24530	COG1053	succinate dehydrogenase
N8I86_RS24550	COG1217	gtp-binding protein TYPA
N8I86_RS24555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8I86_RS24560	COG4166	transmembrane transport
N8I86_RS24565	COG0601	transmembrane transport
N8I86_RS24570	COG0444	Belongs to the ABC transporter superfamily
N8I86_RS24575	COG4608	Belongs to the ABC transporter superfamily
N8I86_RS24590	COG4608	Belongs to the ABC transporter superfamily
N8I86_RS24595	COG0444	Belongs to the ABC transporter superfamily
N8I86_RS24605	COG0747	negative chemotaxis
N8I86_RS24610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8I86_RS24615	COG4166	transmembrane transport
N8I86_RS24620	COG0601	transmembrane transport
N8I86_RS24625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8I86_RS24635	COG4608	Belongs to the ABC transporter superfamily
N8I86_RS24650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N8I86_RS24665	COG1131	(ABC) transporter
N8I86_RS24675	COG4585	Histidine kinase
N8I86_RS24680	COG2197	response regulator
N8I86_RS24715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8I86_RS24720	COG1611	Belongs to the LOG family
N8I86_RS24725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N8I86_RS24735	COG0519	Catalyzes the synthesis of GMP from XMP
N8I86_RS24740	COG1024	Enoyl-CoA hydratase
N8I86_RS24755	COG1595	DNA-templated transcription, initiation
N8I86_RS24765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8I86_RS24770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N8I86_RS24805	COG0598	Magnesium transport protein CorA
N8I86_RS24815	COG2814	Major facilitator Superfamily
N8I86_RS24830	COG2095	MarC family integral membrane protein
N8I86_RS24840	COG1432	Conserved Protein
N8I86_RS24850	COG0513	Belongs to the DEAD box helicase family
N8I86_RS24900	COG0601	transmembrane transport
N8I86_RS24905	COG4172	Belongs to the ABC transporter superfamily
N8I86_RS24970	COG0210	DNA helicase
N8I86_RS24975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8I86_RS24980	COG2816	NAD+ diphosphatase activity
N8I86_RS25020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N8I86_RS25075	COG3480	Lon protease (S16) C-terminal proteolytic domain
N8I86_RS25085	COG1615	UPF0182 protein
N8I86_RS25110	COG0753	catalase activity
N8I86_RS25120	COG0483	inositol monophosphate 1-phosphatase activity
N8I86_RS25130	COG2076	Multidrug Resistance protein
N8I86_RS25135	COG1162	GTPase activity
N8I86_RS25140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N8I86_RS25150	COG2135	peptidase activity
N8I86_RS25160	COG1595	DNA-templated transcription, initiation
N8I86_RS25165	COG5662	AntiSigma factor
N8I86_RS25185	COG0242	peptide deformylase activity
N8I86_RS25195	COG2124	cytochrome p450
N8I86_RS25230	COG2188	Transcriptional regulator
N8I86_RS25235	COG0363	glucosamine-6-phosphate deaminase activity
N8I86_RS25250	COG1597	lipid kinase activity
N8I86_RS25265	COG2172	sigma factor antagonist activity
N8I86_RS25290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8I86_RS25295	COG0142	geranyltranstransferase activity
N8I86_RS25345	COG4106	trans-aconitate 2-methyltransferase activity
N8I86_RS25350	COG1126	abc transporter atp-binding protein
N8I86_RS25365	COG0281	malic enzyme
N8I86_RS25370	COG0604	alcohol dehydrogenase
N8I86_RS25405	COG2205	protein histidine kinase activity
N8I86_RS25410	COG0745	RESPONSE REGULATOR receiver
N8I86_RS25425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N8I86_RS25550	COG2205	protein histidine kinase activity
N8I86_RS25570	COG1793	dna ligase
N8I86_RS25570	COG3285	dna ligase
N8I86_RS25575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N8I86_RS25640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N8I86_RS25645	COG0732	type I restriction modification DNA specificity domain
N8I86_RS25775	COG0018	arginyl-trna synthetase
N8I86_RS25780	COG0018	arginyl-trna synthetase
N8I86_RS25785	COG0019	diaminopimelate decarboxylase activity
N8I86_RS25790	COG0460	homoserine dehydrogenase
N8I86_RS25795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N8I86_RS25800	COG0083	homoserine kinase activity
N8I86_RS25815	COG0254	rRNA binding
N8I86_RS25820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N8I86_RS25825	COG2890	protein-(glutamine-N5) methyltransferase activity
N8I86_RS25835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N8I86_RS25840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N8I86_RS25860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N8I86_RS25865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N8I86_RS25870	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N8I86_RS25875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N8I86_RS25880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N8I86_RS25885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N8I86_RS25890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N8I86_RS25905	COG2197	response regulator
N8I86_RS25930	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8I86_RS25945	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N8I86_RS25980	COG1131	(ABC) transporter
N8I86_RS26005	COG0183	Belongs to the thiolase family
N8I86_RS26085	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS26085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS26120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N8I86_RS26125	COG0280	phosphate acetyltransferase
N8I86_RS26125	COG0857	belongs to the CobB CobQ family
N8I86_RS26130	COG0205	6-phosphofructokinase activity
N8I86_RS26145	COG0395	ABC-type sugar transport system, permease component
N8I86_RS26150	COG1175	transmembrane transport
N8I86_RS26160	COG4565	transcriptional regulatory protein
N8I86_RS26165	COG3290	protein histidine kinase activity
N8I86_RS26180	COG0477	Major facilitator Superfamily
N8I86_RS26195	COG1522	sequence-specific DNA binding
N8I86_RS26205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N8I86_RS26210	COG3281	Trehalose synthase
N8I86_RS26220	COG0366	Alpha amylase catalytic
N8I86_RS26225	COG0058	SHG alpha-glucan phosphorylase activity
N8I86_RS26250	COG1132	(ABC) transporter
N8I86_RS26260	COG1132	(ABC) transporter
N8I86_RS26265	COG1132	(ABC) transporter
N8I86_RS26300	COG1376	ErfK ybiS ycfS ynhG family protein
N8I86_RS26335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8I86_RS26375	COG1760	l-serine dehydratase
N8I86_RS26380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N8I86_RS26385	COG0509	glycine decarboxylation via glycine cleavage system
N8I86_RS26390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N8I86_RS26410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8I86_RS26415	COG0747	negative chemotaxis
N8I86_RS26425	COG0444	Belongs to the ABC transporter superfamily
N8I86_RS26430	COG4608	Belongs to the ABC transporter superfamily
N8I86_RS26440	COG2860	membrane
N8I86_RS26460	COG2378	regulation of single-species biofilm formation
N8I86_RS26490	COG0482	sulfurtransferase activity
N8I86_RS26505	COG1611	Belongs to the LOG family
N8I86_RS26510	COG4221	oxidoreductase activity
N8I86_RS26520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N8I86_RS26545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N8I86_RS26550	COG0154	amidase activity
N8I86_RS26560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N8I86_RS26570	COG2409	Drug exporters of the RND superfamily
N8I86_RS26590	COG2197	response regulator
N8I86_RS26600	COG2133	pyrroloquinoline quinone binding
N8I86_RS26605	COG0667	Aldo Keto reductase
N8I86_RS26615	COG5001	Diguanylate cyclase
N8I86_RS26615	COG3300	MHYT domain
N8I86_RS26625	COG0440	acetolactate synthase activity
N8I86_RS26630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N8I86_RS26635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8I86_RS26640	COG0477	Major facilitator Superfamily
N8I86_RS26655	COG2508	Transcriptional regulator
N8I86_RS26660	COG0506	proline dehydrogenase activity
N8I86_RS26665	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS26670	COG0596	Alpha beta hydrolase
N8I86_RS26685	COG0473	3-isopropylmalate dehydrogenase activity
N8I86_RS26690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N8I86_RS26700	COG0831	urea catabolic process
N8I86_RS26700	COG0832	Belongs to the urease beta subunit family
N8I86_RS26705	COG0804	urea catabolic process
N8I86_RS26710	COG2957	Belongs to the agmatine deiminase family
N8I86_RS26720	COG0477	Major facilitator Superfamily
N8I86_RS26725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8I86_RS26755	COG1472	Belongs to the glycosyl hydrolase 3 family
N8I86_RS26765	COG2353	YceI-like domain
N8I86_RS26780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N8I86_RS26805	COG2018	Roadblock/LC7 domain
N8I86_RS26825	COG2018	Roadblock/LC7 domain
N8I86_RS26830	COG5002	protein histidine kinase activity
N8I86_RS26840	COG0179	Fumarylacetoacetate (FAA) hydrolase
N8I86_RS26845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N8I86_RS26880	COG1414	Transcriptional regulator
N8I86_RS26885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N8I86_RS26890	COG0066	3-isopropylmalate dehydratase activity
N8I86_RS26900	COG0776	regulation of translation
N8I86_RS26910	COG1920	GTP binding
N8I86_RS26920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N8I86_RS26925	COG1181	Belongs to the D-alanine--D-alanine ligase family
N8I86_RS26945	COG0351	phosphomethylpyrimidine kinase
N8I86_RS26950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N8I86_RS26955	COG1461	Dihydroxyacetone kinase
N8I86_RS26965	COG0326	Molecular chaperone. Has ATPase activity
N8I86_RS26980	COG0742	ribosomal rna small subunit methyltransferase
N8I86_RS26985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N8I86_RS27000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N8I86_RS27005	COG0571	ribonuclease III activity
N8I86_RS27010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N8I86_RS27015	COG1733	regulation of RNA biosynthetic process
N8I86_RS27020	COG0655	NAD(P)H dehydrogenase (quinone) activity
N8I86_RS27030	COG2340	Cysteine-rich secretory protein family
N8I86_RS27035	COG1254	Belongs to the acylphosphatase family
N8I86_RS27045	COG1196	nuclear chromosome segregation
N8I86_RS27050	COG0477	Major facilitator Superfamily
N8I86_RS27090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N8I86_RS27100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N8I86_RS27110	COG4106	trans-aconitate 2-methyltransferase activity
N8I86_RS27120	COG0228	four-way junction DNA binding
N8I86_RS27125	COG1837	Belongs to the UPF0109 family
N8I86_RS27130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N8I86_RS27135	COG0336	Belongs to the RNA methyltransferase TrmD family
N8I86_RS27140	COG0335	large ribosomal subunit rRNA binding
N8I86_RS27155	COG0681	Belongs to the peptidase S26 family
N8I86_RS27175	COG0792	nuclease activity
N8I86_RS27190	COG1191	sigma factor activity
N8I86_RS27205	COG0052	Belongs to the universal ribosomal protein uS2 family
N8I86_RS27215	COG0528	UMP kinase activity
N8I86_RS27220	COG0233	cytoplasmic translational termination
N8I86_RS27225	COG0575	Belongs to the CDS family
N8I86_RS27230	COG2124	cytochrome p450
N8I86_RS27245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N8I86_RS27295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N8I86_RS27305	COG4149	molybdate abc transporter
N8I86_RS27310	COG3842	ATPase activity
N8I86_RS27335	COG1136	(ABC) transporter
N8I86_RS27340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N8I86_RS27350	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS27370	COG0584	glycerophosphoryl diester phosphodiesterase
N8I86_RS27375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N8I86_RS27400	COG3842	ATPase activity
N8I86_RS27405	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8I86_RS27410	COG1177	transmembrane transport
N8I86_RS27415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8I86_RS27450	COG1012	belongs to the aldehyde dehydrogenase family
N8I86_RS27460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N8I86_RS27465	COG0750	zinc metalloprotease
N8I86_RS27470	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N8I86_RS27485	COG1247	-acetyltransferase
N8I86_RS27490	COG0442	prolyl-tRNA aminoacylation
N8I86_RS27510	COG0779	Required for maturation of 30S ribosomal subunits
N8I86_RS27525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N8I86_RS27535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N8I86_RS27540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N8I86_RS27570	COG3266	domain, Protein
N8I86_RS27575	COG1404	Belongs to the peptidase S8 family
N8I86_RS27640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8I86_RS27640	COG0515	serine threonine protein kinase
N8I86_RS27645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8I86_RS27645	COG0515	serine threonine protein kinase
N8I86_RS27650	COG1674	ftsk spoiiie
N8I86_RS27665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N8I86_RS27670	COG1185	polyribonucleotide nucleotidyltransferase activity
N8I86_RS27675	COG0612	Peptidase, M16
N8I86_RS27680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N8I86_RS27700	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
N8I86_RS27705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8I86_RS27710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N8I86_RS27745	COG2208	phosphoserine phosphatase activity
N8I86_RS27745	COG2770	Histidine kinase
N8I86_RS27750	COG0784	Response regulator, receiver
N8I86_RS27750	COG2205	protein histidine kinase activity
N8I86_RS27760	COG1674	ftsk spoiiie
N8I86_RS27770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N8I86_RS27780	COG1546	Belongs to the CinA family
N8I86_RS27780	COG1058	Belongs to the CinA family
N8I86_RS27785	COG1396	sequence-specific DNA binding
N8I86_RS27790	COG0783	Belongs to the Dps family
N8I86_RS27800	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS27805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N8I86_RS27840	COG0628	permease
N8I86_RS27865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N8I86_RS27875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8I86_RS27880	COG0765	amino acid transport
N8I86_RS27885	COG0765	amino acid transport
N8I86_RS27890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8I86_RS27895	COG1126	abc transporter atp-binding protein
N8I86_RS27900	COG0745	RESPONSE REGULATOR receiver
N8I86_RS27905	COG0642	Histidine kinase
N8I86_RS27910	COG2358	TRAP transporter, solute receptor (TAXI family
N8I86_RS27940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N8I86_RS27960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N8I86_RS27970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N8I86_RS27975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N8I86_RS27985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N8I86_RS28015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N8I86_RS28020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N8I86_RS28025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N8I86_RS28040	COG0588	phosphoglycerate mutase activity
N8I86_RS28060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N8I86_RS28090	COG1126	abc transporter atp-binding protein
N8I86_RS28100	COG1802	Transcriptional regulator
N8I86_RS28105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N8I86_RS28120	COG0187	DNA topoisomerase II activity
N8I86_RS28130	COG4585	Histidine kinase
N8I86_RS28135	COG2197	response regulator
N8I86_RS28145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8I86_RS28160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8I86_RS28170	COG4565	transcriptional regulatory protein
N8I86_RS28175	COG3290	protein histidine kinase activity
N8I86_RS28190	COG0372	Belongs to the citrate synthase family
N8I86_RS28210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N8I86_RS28215	COG0612	Peptidase, M16
N8I86_RS28230	COG1802	Transcriptional regulator
N8I86_RS28235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8I86_RS28255	COG1435	thymidine kinase activity
N8I86_RS28300	COG0745	RESPONSE REGULATOR receiver
N8I86_RS28305	COG2205	protein histidine kinase activity
N8I86_RS28330	COG0756	dUTP diphosphatase activity
N8I86_RS28340	COG1136	(ABC) transporter
N8I86_RS28370	COG0569	domain protein
N8I86_RS28380	COG0531	amino acid
N8I86_RS28385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N8I86_RS28390	COG1278	Cold shock
N8I86_RS28395	COG0513	Belongs to the DEAD box helicase family
N8I86_RS28415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N8I86_RS28430	COG3321	synthase
N8I86_RS28430	COG0604	alcohol dehydrogenase
N8I86_RS28435	COG3321	synthase
N8I86_RS28435	COG0604	alcohol dehydrogenase
N8I86_RS28465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N8I86_RS28480	COG3629	intracellular signal transduction
N8I86_RS28525	COG1799	cell septum assembly
N8I86_RS28570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N8I86_RS28595	COG2235	arginine
N8I86_RS28600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N8I86_RS28605	COG0531	amino acid
N8I86_RS28615	COG1024	Enoyl-CoA hydratase
N8I86_RS28660	COG2188	Transcriptional regulator
N8I86_RS28665	COG2182	Extracellular solute-binding protein
N8I86_RS28670	COG1175	transmembrane transport
N8I86_RS28675	COG0395	ABC-type sugar transport system, permease component
N8I86_RS28680	COG1472	Belongs to the glycosyl hydrolase 3 family
N8I86_RS28710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N8I86_RS28725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS28750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N8I86_RS28760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N8I86_RS28770	COG3537	Alpha-1,2-mannosidase
N8I86_RS28780	COG1653	transport
N8I86_RS28785	COG1175	transmembrane transport
N8I86_RS28790	COG0395	ABC-type sugar transport system, permease component
N8I86_RS28795	COG1940	carbohydrate kinase activity
N8I86_RS28800	COG4213	ABC transporter substrate-binding protein
N8I86_RS28810	COG4214	carbohydrate transport
N8I86_RS28815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N8I86_RS28820	COG0531	amino acid
N8I86_RS28840	COG1316	TRANSCRIPTIONal
N8I86_RS28860	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8I86_RS28860	COG1024	Enoyl-CoA hydratase
N8I86_RS28865	COG0183	Belongs to the thiolase family
N8I86_RS28870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N8I86_RS28885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N8I86_RS28900	COG0446	pyridine nucleotide-disulphide oxidoreductase
N8I86_RS28910	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N8I86_RS28915	COG3253	May function as heme-dependent peroxidase
N8I86_RS28960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8I86_RS28960	COG0723	plastoquinol--plastocyanin reductase activity
N8I86_RS28965	COG0330	HflC and HflK could
N8I86_RS29000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N8I86_RS29005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N8I86_RS29020	COG1174	glycine betaine transport
N8I86_RS29025	COG1174	glycine betaine transport
N8I86_RS29150	COG3733	amine oxidase
N8I86_RS29185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N8I86_RS29190	COG1595	DNA-templated transcription, initiation
N8I86_RS29210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8I86_RS29210	COG1116	anion transmembrane transporter activity
N8I86_RS29230	COG0529	Catalyzes the synthesis of activated sulfate
N8I86_RS29235	COG0175	sulfate reduction
N8I86_RS29265	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS29290	COG3739	integral membrane protein
N8I86_RS29295	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N8I86_RS29315	COG2040	homocysteine
N8I86_RS29330	COG0596	Alpha beta hydrolase
N8I86_RS29345	COG1940	carbohydrate kinase activity
N8I86_RS29350	COG0277	FAD linked oxidase domain protein
N8I86_RS29355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8I86_RS29370	COG4447	cellulose binding
N8I86_RS29370	COG5520	Belongs to the glycosyl hydrolase 30 family
N8I86_RS29370	COG3291	Pkd domain containing protein
N8I86_RS29375	COG1162	GTPase activity
N8I86_RS29385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N8I86_RS29410	COG0028	Belongs to the TPP enzyme family
N8I86_RS29430	COG1802	Transcriptional regulator
N8I86_RS29455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8I86_RS29460	COG2252	PERMEase
N8I86_RS29495	COG0598	Magnesium transport protein CorA
N8I86_RS29515	COG2197	response regulator
N8I86_RS29520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N8I86_RS29525	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS29535	COG3960	tartronate-semialdehyde synthase activity
N8I86_RS29550	COG0753	catalase activity
N8I86_RS29555	COG2084	Dehydrogenase
N8I86_RS29560	COG3622	Belongs to the hyi family
N8I86_RS29580	COG2351	hydroxyisourate hydrolase activity
N8I86_RS29590	COG2233	PERMEase
N8I86_RS29600	COG2233	PERMEase
N8I86_RS29610	COG0702	epimerase
N8I86_RS29625	COG0406	alpha-ribazole phosphatase activity
N8I86_RS29635	COG0436	Aminotransferase
N8I86_RS29640	COG1733	regulation of RNA biosynthetic process
N8I86_RS29655	COG4264	IucA IucC family
N8I86_RS29675	COG3629	intracellular signal transduction
N8I86_RS29675	COG3903	Transcriptional regulator
N8I86_RS29680	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
N8I86_RS29685	COG0235	Class ii aldolase
N8I86_RS29685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N8I86_RS29705	COG2264	protein methyltransferase activity
N8I86_RS29710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N8I86_RS29715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8I86_RS29725	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N8I86_RS29740	COG1414	Transcriptional regulator
N8I86_RS29745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N8I86_RS29750	COG4266	Belongs to the allantoicase family
N8I86_RS29785	COG2197	response regulator
N8I86_RS29795	COG0673	inositol 2-dehydrogenase activity
N8I86_RS29800	COG2188	Transcriptional regulator
N8I86_RS29820	COG1940	carbohydrate kinase activity
N8I86_RS29830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N8I86_RS29845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS29850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N8I86_RS29865	COG1126	abc transporter atp-binding protein
N8I86_RS29870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8I86_RS29875	COG0765	amino acid transport
N8I86_RS29880	COG0765	amino acid transport
N8I86_RS29900	COG0405	Gamma-glutamyltransferase
N8I86_RS29905	COG0542	response to heat
N8I86_RS29930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N8I86_RS29945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N8I86_RS29955	COG1953	Uracil, thiamine, allantoin
N8I86_RS29980	COG0483	inositol monophosphate 1-phosphatase activity
N8I86_RS29995	COG3629	intracellular signal transduction
N8I86_RS30010	COG0477	Major facilitator Superfamily
N8I86_RS30030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N8I86_RS30040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8I86_RS30045	COG2226	methyltransferase
N8I86_RS30050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N8I86_RS30055	COG1233	COG1233 Phytoene dehydrogenase and related
N8I86_RS30065	COG0489	protein tyrosine kinase activity
N8I86_RS30075	COG2409	Drug exporters of the RND superfamily
N8I86_RS30100	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS30115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS30115	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS30115	COG0300	oxidoreductase activity
N8I86_RS30115	COG3321	synthase
N8I86_RS30115	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS30125	COG0604	alcohol dehydrogenase
N8I86_RS30125	COG3321	synthase
N8I86_RS30130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8I86_RS30140	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8I86_RS30165	COG3629	intracellular signal transduction
N8I86_RS30165	COG3903	Transcriptional regulator
N8I86_RS30180	COG1013	pyruvate-flavodoxin oxidoreductase activity
N8I86_RS30185	COG0674	pyruvate-flavodoxin oxidoreductase activity
N8I86_RS30185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N8I86_RS30195	COG2197	response regulator
N8I86_RS30200	COG4585	Histidine kinase
N8I86_RS30225	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS30260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N8I86_RS30275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N8I86_RS30310	COG0688	phosphatidylethanolamine metabolic process
N8I86_RS30315	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS30330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS30330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N8I86_RS30335	COG0604	alcohol dehydrogenase
N8I86_RS30345	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8I86_RS30385	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS30385	COG2208	phosphoserine phosphatase activity
N8I86_RS30385	COG2172	sigma factor antagonist activity
N8I86_RS30390	COG4106	trans-aconitate 2-methyltransferase activity
N8I86_RS30395	COG2362	D-Aminopeptidase
N8I86_RS30400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8I86_RS30410	COG1619	proteins homologs of microcin C7 resistance protein MccF
N8I86_RS30440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS30510	COG2226	methyltransferase
N8I86_RS30520	COG0406	alpha-ribazole phosphatase activity
N8I86_RS30525	COG0488	(ABC) transporter
N8I86_RS30540	COG0693	protein deglycase activity
N8I86_RS30550	COG0028	Belongs to the TPP enzyme family
N8I86_RS30575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N8I86_RS30595	COG0443	Heat shock 70 kDa protein
N8I86_RS30655	COG2154	pterin-4-alpha-carbinolamine dehydratase
N8I86_RS30685	COG0656	L-ascorbic acid biosynthetic process
N8I86_RS30695	COG0583	DNA-binding transcription factor activity
N8I86_RS30715	COG1846	Transcriptional regulator
N8I86_RS30720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N8I86_RS30730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8I86_RS30755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N8I86_RS30760	COG0222	ribosome binding
N8I86_RS30765	COG1940	carbohydrate kinase activity
N8I86_RS30770	COG2182	Extracellular solute-binding protein
N8I86_RS30775	COG1175	transmembrane transport
N8I86_RS30780	COG0395	ABC-type sugar transport system, permease component
N8I86_RS30785	COG2723	6-phospho-beta-galactosidase activity
N8I86_RS30820	COG0297	glycogen (starch) synthase activity
N8I86_RS30840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N8I86_RS30855	COG0477	Major facilitator Superfamily
N8I86_RS30865	COG3467	pyridoxamine 5'-phosphate
N8I86_RS30870	COG2084	Dehydrogenase
N8I86_RS30890	COG0588	phosphoglycerate mutase activity
N8I86_RS30895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N8I86_RS30900	COG0166	Belongs to the GPI family
N8I86_RS30915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N8I86_RS30920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N8I86_RS30945	COG1486	melibiose metabolic process
N8I86_RS30950	COG3469	chitinase activity
N8I86_RS30960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N8I86_RS30995	COG1175	transmembrane transport
N8I86_RS31000	COG0395	ABC-type sugar transport system, permease component
N8I86_RS31005	COG0366	Alpha amylase catalytic
N8I86_RS31025	COG1595	DNA-templated transcription, initiation
N8I86_RS31035	COG3629	intracellular signal transduction
N8I86_RS31035	COG3903	Transcriptional regulator
N8I86_RS31055	COG3511	phospholipase C
N8I86_RS31085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N8I86_RS31090	COG0477	Major facilitator Superfamily
N8I86_RS31100	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS31110	COG3485	protocatechuate 3,4-dioxygenase
N8I86_RS31115	COG3485	protocatechuate 3,4-dioxygenase
N8I86_RS31140	COG1470	cell adhesion involved in biofilm formation
N8I86_RS31150	COG1793	dna ligase
N8I86_RS31180	COG1834	amidinotransferase
N8I86_RS31185	COG0488	(ABC) transporter
N8I86_RS31215	COG1515	deoxyribonuclease V activity
N8I86_RS31220	COG3268	Saccharopine dehydrogenase
N8I86_RS31260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8I86_RS31265	COG0183	Belongs to the thiolase family
N8I86_RS31270	COG1024	Enoyl-CoA hydratase
N8I86_RS31270	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8I86_RS31280	COG1113	amino acid transport
N8I86_RS31290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8I86_RS31315	COG0488	(ABC) transporter
N8I86_RS31320	COG2183	response to ionizing radiation
N8I86_RS31330	COG4977	sequence-specific DNA binding
N8I86_RS31340	COG1024	Enoyl-CoA hydratase
N8I86_RS31350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N8I86_RS31395	COG1134	teichoic acid transport
N8I86_RS31400	COG1562	ergosterol biosynthetic process
N8I86_RS31410	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N8I86_RS31420	COG1657	PFAM Prenyltransferase squalene oxidase
N8I86_RS31435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N8I86_RS31440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N8I86_RS31465	COG2365	Tyrosine phosphatase family
N8I86_RS31480	COG2755	lipolytic protein G-D-S-L family
N8I86_RS31490	COG3973	AAA domain
N8I86_RS31530	COG1063	alcohol dehydrogenase
N8I86_RS31535	COG0156	8-amino-7-oxononanoate synthase activity
N8I86_RS31540	COG0583	DNA-binding transcription factor activity
N8I86_RS31565	COG3958	Transketolase
N8I86_RS31570	COG3959	Transketolase, thiamine diphosphate binding domain
N8I86_RS31610	COG0561	phosphatase activity
N8I86_RS31655	COG2267	carboxylic ester hydrolase activity
N8I86_RS31660	COG0183	Belongs to the thiolase family
N8I86_RS31665	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS31720	COG0395	ABC-type sugar transport system, permease component
N8I86_RS31735	COG2188	Transcriptional regulator
N8I86_RS31760	COG0673	inositol 2-dehydrogenase activity
N8I86_RS31765	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS31785	COG0673	inositol 2-dehydrogenase activity
N8I86_RS31790	COG1609	Transcriptional regulator
N8I86_RS31810	COG0477	Major facilitator Superfamily
N8I86_RS31820	COG0531	amino acid
N8I86_RS31830	COG3938	Belongs to the proline racemase family
N8I86_RS31835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8I86_RS31870	COG2197	response regulator
N8I86_RS31910	COG2124	cytochrome p450
N8I86_RS31920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N8I86_RS31930	COG2838	Isocitrate dehydrogenase
N8I86_RS32000	COG3387	PFAM Glycoside hydrolase 15-related
N8I86_RS32005	COG0477	Major facilitator Superfamily
N8I86_RS32010	COG0668	transmembrane transport
N8I86_RS32015	COG0531	amino acid
N8I86_RS32025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N8I86_RS32045	COG1024	Enoyl-CoA hydratase
N8I86_RS32060	COG1132	(ABC) transporter
N8I86_RS32065	COG3469	chitinase activity
N8I86_RS32080	COG2080	2 iron, 2 sulfur cluster binding
N8I86_RS32085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N8I86_RS32090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8I86_RS32130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8I86_RS32130	COG2080	2 iron, 2 sulfur cluster binding
N8I86_RS32145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N8I86_RS32155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N8I86_RS32175	COG0297	glycogen (starch) synthase activity
N8I86_RS32180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N8I86_RS32185	COG3537	Alpha-1,2-mannosidase
N8I86_RS32215	COG1609	Transcriptional regulator
N8I86_RS32225	COG1175	transmembrane transport
N8I86_RS32230	COG0395	ABC-type sugar transport system, permease component
N8I86_RS32270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N8I86_RS32300	COG0531	amino acid
N8I86_RS32315	COG0726	polysaccharide deacetylase
N8I86_RS32390	COG0583	DNA-binding transcription factor activity
N8I86_RS32400	COG1053	succinate dehydrogenase
N8I86_RS32405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N8I86_RS32440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS32450	COG3360	Dodecin
N8I86_RS32455	COG2182	Extracellular solute-binding protein
N8I86_RS32460	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
N8I86_RS32465	COG0121	glutamine amidotransferase
N8I86_RS32470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N8I86_RS32475	COG3572	ergothioneine biosynthetic process
N8I86_RS32490	COG2268	Band 7 protein
N8I86_RS32530	COG1309	transcriptional regulator
N8I86_RS32545	COG1609	Transcriptional regulator
N8I86_RS32550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8I86_RS32560	COG0242	peptide deformylase activity
N8I86_RS32605	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N8I86_RS32610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N8I86_RS32615	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N8I86_RS32630	COG3158	transport of potassium into the cell
N8I86_RS32665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N8I86_RS32680	COG0604	alcohol dehydrogenase
N8I86_RS32700	COG0542	response to heat
N8I86_RS32710	COG1174	glycine betaine transport
N8I86_RS32715	COG1174	glycine betaine transport
N8I86_RS32730	COG1556	Lactate utilization protein
N8I86_RS32735	COG1139	Iron-sulfur cluster binding protein
N8I86_RS32740	COG0247	lactate metabolic process
N8I86_RS32745	COG1070	Carbohydrate kinase
N8I86_RS32750	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS32750	COG3347	Dehydrogenase
N8I86_RS32760	COG1129	ABC transporter
N8I86_RS32770	COG1172	Belongs to the binding-protein-dependent transport system permease family
N8I86_RS32785	COG1609	Transcriptional regulator
N8I86_RS32795	COG1357	PFAM Pentapeptide repeats (8 copies)
N8I86_RS32805	COG1309	transcriptional regulator
N8I86_RS32815	COG2706	6-phosphogluconolactonase activity
N8I86_RS32865	COG0546	phosphoglycolate phosphatase activity
N8I86_RS32870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N8I86_RS32870	COG1796	DNA polymerase
N8I86_RS32875	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS32920	COG1006	Multisubunit Na H antiporter MnhC subunit
N8I86_RS32925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8I86_RS32935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N8I86_RS32940	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS32960	COG0531	amino acid
N8I86_RS32985	COG0435	Glutathione S-transferase
N8I86_RS33000	COG2124	cytochrome p450
N8I86_RS33020	COG0667	Aldo Keto reductase
N8I86_RS33070	COG1595	DNA-templated transcription, initiation
N8I86_RS33125	COG2890	protein-(glutamine-N5) methyltransferase activity
N8I86_RS33170	COG0726	polysaccharide deacetylase
N8I86_RS33220	COG2197	response regulator
N8I86_RS33240	COG0515	serine threonine protein kinase
N8I86_RS33255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N8I86_RS33265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8I86_RS33310	COG0277	FAD linked oxidase domain protein
N8I86_RS33310	COG0247	lactate metabolic process
N8I86_RS33315	COG4948	Mandelate Racemase Muconate Lactonizing
N8I86_RS33320	COG0300	oxidoreductase activity
N8I86_RS33340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N8I86_RS33400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8I86_RS33415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N8I86_RS33445	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS33450	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS33455	COG0076	glutamate decarboxylase activity
N8I86_RS33490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N8I86_RS33510	COG1309	transcriptional regulator
N8I86_RS33550	COG0572	uridine kinase
N8I86_RS33600	COG3387	PFAM Glycoside hydrolase 15-related
N8I86_RS33610	COG3290	protein histidine kinase activity
N8I86_RS33690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N8I86_RS33750	COG0584	glycerophosphoryl diester phosphodiesterase
N8I86_RS33780	COG0667	Aldo Keto reductase
N8I86_RS33790	COG2124	cytochrome p450
N8I86_RS33815	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N8I86_RS33830	COG3469	chitinase activity
N8I86_RS33850	COG0248	Ppx GppA phosphatase
N8I86_RS33895	COG2172	sigma factor antagonist activity
N8I86_RS33900	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS33905	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS33955	COG2197	response regulator
N8I86_RS34005	COG1132	(ABC) transporter
N8I86_RS34110	COG1278	Cold shock
N8I86_RS34125	COG0477	Major facilitator Superfamily
N8I86_RS34170	COG1335	isochorismatase
N8I86_RS34195	COG0437	4 iron, 4 sulfur cluster binding
N8I86_RS34215	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS34255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS34270	COG1309	transcriptional regulator
N8I86_RS34280	COG0517	IMP dehydrogenase activity
N8I86_RS34320	COG1177	transmembrane transport
N8I86_RS34325	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8I86_RS34330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N8I86_RS34335	COG3842	ATPase activity
N8I86_RS34360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N8I86_RS34365	COG1733	regulation of RNA biosynthetic process
N8I86_RS34395	COG0402	S-adenosylhomocysteine deaminase activity
N8I86_RS34400	COG2233	PERMEase
N8I86_RS34405	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS34425	COG0488	(ABC) transporter
N8I86_RS34445	COG0277	FAD linked oxidase domain protein
N8I86_RS34450	COG1597	lipid kinase activity
N8I86_RS34465	COG2837	iron assimilation
N8I86_RS34470	COG0542	response to heat
N8I86_RS34490	COG0823	Involved in the tonB-independent uptake of proteins
N8I86_RS34520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS34605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N8I86_RS34615	COG2208	phosphoserine phosphatase activity
N8I86_RS34625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N8I86_RS34630	COG2124	cytochrome p450
N8I86_RS34655	COG1295	ribonuclease BN
N8I86_RS34705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8I86_RS34710	COG3275	phosphorelay sensor kinase activity
N8I86_RS34750	COG3425	synthase
N8I86_RS34755	COG1024	Enoyl-CoA hydratase
N8I86_RS34770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8I86_RS34770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8I86_RS34770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS34770	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS34770	COG3321	synthase
N8I86_RS34785	COG2070	2-Nitropropane dioxygenase
N8I86_RS34785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N8I86_RS34810	COG2226	methyltransferase
N8I86_RS34815	COG2267	carboxylic ester hydrolase activity
N8I86_RS34830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8I86_RS34830	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS34830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS34830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8I86_RS34830	COG3321	synthase
N8I86_RS34840	COG3425	synthase
N8I86_RS34845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8I86_RS34850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8I86_RS34860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N8I86_RS34865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8I86_RS34870	COG3629	intracellular signal transduction
N8I86_RS34870	COG3903	Transcriptional regulator
N8I86_RS34890	COG4249	Peptidase C14 caspase catalytic subunit p20
N8I86_RS34890	COG2319	Wd-40 repeat
N8I86_RS34920	COG1017	nitric oxide dioxygenase activity
N8I86_RS34920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N8I86_RS34945	COG2409	Drug exporters of the RND superfamily
N8I86_RS34960	COG0318	PFAM AMP-dependent synthetase and ligase
N8I86_RS34965	COG0477	Major facilitator Superfamily
N8I86_RS35000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N8I86_RS35015	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS35015	COG2208	phosphoserine phosphatase activity
N8I86_RS35015	COG2172	sigma factor antagonist activity
N8I86_RS35020	COG0277	FAD linked oxidase domain protein
N8I86_RS35040	COG2080	2 iron, 2 sulfur cluster binding
N8I86_RS35045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N8I86_RS35050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8I86_RS35075	COG4977	sequence-specific DNA binding
N8I86_RS35095	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS35155	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS35230	COG1191	sigma factor activity
N8I86_RS35235	COG0784	Response regulator, receiver
N8I86_RS35255	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N8I86_RS35255	COG2308	Evidence 4 Homologs of previously reported genes of
N8I86_RS35260	COG0367	asparagine synthase
N8I86_RS35310	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS35315	COG1271	oxidase subunit
N8I86_RS35330	COG3387	PFAM Glycoside hydrolase 15-related
N8I86_RS35350	COG0598	Magnesium transport protein CorA
N8I86_RS35375	COG0739	heme binding
N8I86_RS35415	COG0514	ATP-dependent DNA helicase (RecQ)
N8I86_RS35435	COG2345	Transcriptional regulator
N8I86_RS35440	COG1960	acyl-CoA dehydrogenase activity
N8I86_RS35450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8I86_RS35455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8I86_RS35460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8I86_RS35505	COG3629	intracellular signal transduction
N8I86_RS35530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8I86_RS35535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N8I86_RS35540	COG2267	carboxylic ester hydrolase activity
N8I86_RS35560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N8I86_RS35570	COG1088	dTDP-glucose 4,6-dehydratase activity
N8I86_RS35575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N8I86_RS35620	COG1215	transferase activity, transferring glycosyl groups
N8I86_RS35645	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N8I86_RS35695	COG4585	Histidine kinase
N8I86_RS35700	COG2197	response regulator
N8I86_RS35725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N8I86_RS35740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8I86_RS35785	COG0596	Alpha beta hydrolase
N8I86_RS35790	COG2226	methyltransferase
N8I86_RS35810	COG0745	RESPONSE REGULATOR receiver
N8I86_RS35815	COG2205	protein histidine kinase activity
N8I86_RS35825	COG0745	RESPONSE REGULATOR receiver
N8I86_RS35930	COG2198	Histidine kinase
N8I86_RS35930	COG5002	protein histidine kinase activity
N8I86_RS35930	COG0784	Response regulator, receiver
N8I86_RS35945	COG2172	sigma factor antagonist activity
N8I86_RS35950	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS35955	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS35965	COG2205	protein histidine kinase activity
N8I86_RS35980	COG0697	spore germination
N8I86_RS36005	COG0151	Belongs to the GarS family
N8I86_RS36020	COG2197	response regulator
N8I86_RS36055	COG1295	ribonuclease BN
N8I86_RS36065	COG2208	phosphoserine phosphatase activity
N8I86_RS36105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N8I86_RS36110	COG2208	phosphoserine phosphatase activity
N8I86_RS36145	COG3795	YCII-related domain
N8I86_RS36150	COG4941	Belongs to the sigma-70 factor family
N8I86_RS36160	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N8I86_RS36180	COG2264	protein methyltransferase activity
N8I86_RS36225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS36235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N8I86_RS36240	COG1120	ATPase activity
N8I86_RS36245	COG4585	Histidine kinase
N8I86_RS36265	COG2072	flavoprotein involved in K transport
N8I86_RS36405	COG3537	Alpha-1,2-mannosidase
N8I86_RS36410	COG3848	Pyruvate phosphate dikinase
N8I86_RS36410	COG0574	Belongs to the PEP-utilizing enzyme family
N8I86_RS36425	COG2188	Transcriptional regulator
N8I86_RS36445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N8I86_RS36450	COG5297	Belongs to the glycosyl hydrolase family 6
N8I86_RS36490	COG1595	DNA-templated transcription, initiation
N8I86_RS36495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8I86_RS36515	COG0202	RNA polymerase activity
N8I86_RS36535	COG2192	nodulation
N8I86_RS36550	COG0105	UTP biosynthetic process
N8I86_RS36605	COG4555	ABC transporter
N8I86_RS36610	COG1492	cobalamin metabolic process
N8I86_RS36635	COG3903	Transcriptional regulator
N8I86_RS36635	COG3629	intracellular signal transduction
N8I86_RS36685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8I86_RS36695	COG0604	alcohol dehydrogenase
N8I86_RS36700	COG0438	transferase activity, transferring glycosyl groups
N8I86_RS36705	COG2205	protein histidine kinase activity
N8I86_RS36735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8I86_RS36750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N8I86_RS36770	COG3629	intracellular signal transduction
N8I86_RS36770	COG3903	Transcriptional regulator
N8I86_RS36780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N8I86_RS36865	COG0596	Alpha beta hydrolase
N8I86_RS36890	COG0583	DNA-binding transcription factor activity
N8I86_RS36895	COG2130	NADP-dependent
N8I86_RS36920	COG0745	RESPONSE REGULATOR receiver
N8I86_RS36925	COG2205	protein histidine kinase activity
N8I86_RS36935	COG0640	Transcriptional regulator
N8I86_RS37035	COG1366	Belongs to the anti-sigma-factor antagonist family
N8I86_RS37050	COG0326	Molecular chaperone. Has ATPase activity
N8I86_RS37180	COG2223	nitrite transmembrane transporter activity
N8I86_RS37185	COG1349	DNA-binding transcription factor activity
N8I86_RS37190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8I86_RS37225	COG2226	methyltransferase
N8I86_RS37230	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N8I86_RS37235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N8I86_RS37255	COG0789	Transcriptional regulator
N8I86_RS37295	COG0583	DNA-binding transcription factor activity
N8I86_RS37330	COG2318	DinB family
N8I86_RS37335	COG0477	Major facilitator Superfamily
N8I86_RS37365	COG1309	transcriptional regulator
N8I86_RS37375	COG3665	Urea carboxylase-associated protein
N8I86_RS37390	COG0583	DNA-binding transcription factor activity
N8I86_RS37425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N8I86_RS37485	COG1971	Probably functions as a manganese efflux pump
N8I86_RS37490	COG0535	radical SAM domain protein
N8I86_RS37505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N8I86_RS37530	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N8I86_RS37535	COG3284	Transcriptional regulator
N8I86_RS37555	COG4948	Mandelate Racemase Muconate Lactonizing
N8I86_RS37580	COG0531	amino acid
N8I86_RS37625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8I86_RS37705	COG1819	glycosyl
N8I86_RS37720	COG1181	Belongs to the D-alanine--D-alanine ligase family
N8I86_RS37725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS37755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N8I86_RS37765	COG0069	glutamate synthase activity
N8I86_RS37770	COG0028	Belongs to the TPP enzyme family
N8I86_RS37780	COG1028	Short-chain dehydrogenase reductase Sdr
N8I86_RS37785	COG1959	2 iron, 2 sulfur cluster binding
N8I86_RS37840	COG0572	uridine kinase
N8I86_RS37855	COG0477	Major facilitator Superfamily
N8I86_RS37875	COG0583	DNA-binding transcription factor activity
N8I86_RS37950	COG2378	regulation of single-species biofilm formation
N8I86_RS38005	COG0509	glycine decarboxylation via glycine cleavage system
N8I86_RS38050	COG2135	peptidase activity
N8I86_RS38055	COG1278	Cold shock
N8I86_RS38090	COG2755	lipolytic protein G-D-S-L family
N8I86_RS38090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N8I86_RS38105	COG1136	(ABC) transporter
N8I86_RS38270	COG1131	(ABC) transporter
N8I86_RS38290	COG2197	response regulator
N8I86_RS38310	COG2124	cytochrome p450
N8I86_RS38340	COG0596	Alpha beta hydrolase
N8I86_RS38405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N8I86_RS38470	COG1846	Transcriptional regulator
N8I86_RS38475	COG0446	pyridine nucleotide-disulphide oxidoreductase
N8I86_RS38475	COG1902	pentaerythritol trinitrate reductase activity
N8I86_RS38560	COG3655	Transcriptional regulator
N8I86_RS38720	COG3903	Transcriptional regulator
N8I86_RS38720	COG3629	intracellular signal transduction
N8I86_RS38765	COG1475	DNA binding