locus-tag	class	description
O1G22_RS00045	COG2267	carboxylic ester hydrolase activity
O1G22_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS00080	COG1309	transcriptional regulator
O1G22_RS00150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1G22_RS00185	COG3896	Chloramphenicol phosphotransferase-like protein
O1G22_RS00205	COG3328	transposase activity
O1G22_RS00235	COG0702	epimerase
O1G22_RS00240	COG1733	regulation of RNA biosynthetic process
O1G22_RS00265	COG2755	lipolytic protein G-D-S-L family
O1G22_RS00265	COG0657	acetylesterase activity
O1G22_RS00280	COG3507	Belongs to the glycosyl hydrolase 43 family
O1G22_RS00285	COG3534	alpha-L-arabinofuranosidase
O1G22_RS00300	COG1609	Transcriptional regulator
O1G22_RS00305	COG0395	ABC-type sugar transport system, permease component
O1G22_RS00310	COG4209	transmembrane transport
O1G22_RS00320	COG1472	Belongs to the glycosyl hydrolase 3 family
O1G22_RS00390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O1G22_RS00395	COG1113	amino acid transport
O1G22_RS00420	COG2801	Transposase and inactivated derivatives
O1G22_RS00420	COG3415	Transposase
O1G22_RS00425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1G22_RS00475	COG1595	DNA-templated transcription, initiation
O1G22_RS00490	COG1309	transcriptional regulator
O1G22_RS00510	COG3665	Urea carboxylase-associated protein
O1G22_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS00540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1G22_RS00540	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS00540	COG0300	oxidoreductase activity
O1G22_RS00540	COG3321	synthase
O1G22_RS00555	COG2175	clavaminate synthase activity
O1G22_RS00580	COG0531	amino acid
O1G22_RS00780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1G22_RS00795	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
O1G22_RS00805	COG2205	protein histidine kinase activity
O1G22_RS00810	COG0745	RESPONSE REGULATOR receiver
O1G22_RS00855	COG3415	Transposase
O1G22_RS00855	COG2801	Transposase and inactivated derivatives
O1G22_RS00870	COG2197	response regulator
O1G22_RS00880	COG1309	transcriptional regulator
O1G22_RS00905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1G22_RS00975	COG0583	DNA-binding transcription factor activity
O1G22_RS01000	COG3507	Belongs to the glycosyl hydrolase 43 family
O1G22_RS01060	COG3345	alpha-galactosidase
O1G22_RS01120	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O1G22_RS01125	COG0500	methyltransferase
O1G22_RS01185	COG3534	alpha-L-arabinofuranosidase
O1G22_RS01200	COG3293	Transposase
O1G22_RS01240	COG3293	Transposase
O1G22_RS01255	COG1595	DNA-templated transcription, initiation
O1G22_RS01275	COG2207	Transcriptional regulator
O1G22_RS01275	COG1609	Transcriptional regulator
O1G22_RS01300	COG4209	transmembrane transport
O1G22_RS01325	COG3458	cephalosporin-C deacetylase activity
O1G22_RS01335	COG1501	Belongs to the glycosyl hydrolase 31 family
O1G22_RS01345	COG1301	dicarboxylic acid transport
O1G22_RS01350	COG2828	Protein conserved in bacteria
O1G22_RS01370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O1G22_RS01375	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
O1G22_RS01385	COG1215	transferase activity, transferring glycosyl groups
O1G22_RS01395	COG4310	Domain of unknown function (DUF2172)
O1G22_RS01410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O1G22_RS01420	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS01445	COG0367	asparagine synthase
O1G22_RS01465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O1G22_RS01470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1G22_RS01475	COG3328	transposase activity
O1G22_RS01500	COG3903	Transcriptional regulator
O1G22_RS01500	COG3629	intracellular signal transduction
O1G22_RS01550	COG2249	NAD(P)H dehydrogenase (quinone) activity
O1G22_RS01565	COG3547	Transposase (IS116 IS110 IS902 family)
O1G22_RS01575	COG1733	regulation of RNA biosynthetic process
O1G22_RS01600	COG5280	Phage tail tape measure protein TP901
O1G22_RS01600	COG3953	SLT domain
O1G22_RS01730	COG1802	Transcriptional regulator
O1G22_RS01740	COG1301	dicarboxylic acid transport
O1G22_RS01810	COG0745	RESPONSE REGULATOR receiver
O1G22_RS01815	COG2205	protein histidine kinase activity
O1G22_RS01875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O1G22_RS01900	COG1278	Cold shock
O1G22_RS01905	COG0513	Belongs to the DEAD box helicase family
O1G22_RS01945	COG2329	Antibiotic biosynthesis monooxygenase
O1G22_RS01990	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1G22_RS02005	COG0596	Alpha beta hydrolase
O1G22_RS02120	COG0515	serine threonine protein kinase
O1G22_RS02120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS02125	COG0778	Nitroreductase
O1G22_RS02130	COG0154	amidase activity
O1G22_RS02135	COG1309	transcriptional regulator
O1G22_RS02165	COG1309	transcriptional regulator
O1G22_RS02180	COG3328	transposase activity
O1G22_RS02195	COG1021	2,3-dihydroxybenzoate-AMP ligase
O1G22_RS02205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1G22_RS02210	COG2226	methyltransferase
O1G22_RS02215	COG0583	DNA-binding transcription factor activity
O1G22_RS02255	COG2815	serine threonine protein kinase
O1G22_RS02255	COG0515	serine threonine protein kinase
O1G22_RS02275	COG0406	alpha-ribazole phosphatase activity
O1G22_RS02290	COG1309	transcriptional regulator
O1G22_RS02295	COG1472	Belongs to the glycosyl hydrolase 3 family
O1G22_RS02305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O1G22_RS02320	COG0384	phenazine biosynthesis protein PhzF
O1G22_RS02340	COG1129	ABC transporter
O1G22_RS02345	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1G22_RS02360	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1G22_RS02415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1G22_RS02430	COG1733	regulation of RNA biosynthetic process
O1G22_RS02455	COG1131	(ABC) transporter
O1G22_RS02460	COG2205	protein histidine kinase activity
O1G22_RS02465	COG0745	RESPONSE REGULATOR receiver
O1G22_RS02480	COG2267	carboxylic ester hydrolase activity
O1G22_RS02495	COG1309	transcriptional regulator
O1G22_RS02535	COG1741	Belongs to the pirin family
O1G22_RS02540	COG4941	Belongs to the sigma-70 factor family
O1G22_RS02545	COG3795	YCII-related domain
O1G22_RS02550	COG0726	polysaccharide deacetylase
O1G22_RS02585	COG0701	Predicted permease
O1G22_RS02600	COG0477	Major facilitator Superfamily
O1G22_RS02605	COG3537	Alpha-1,2-mannosidase
O1G22_RS02630	COG2186	Transcriptional regulator
O1G22_RS02640	COG1024	Enoyl-CoA hydratase
O1G22_RS02685	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS02695	COG1595	DNA-templated transcription, initiation
O1G22_RS02700	COG1349	DNA-binding transcription factor activity
O1G22_RS02710	COG0363	glucosamine-6-phosphate deaminase activity
O1G22_RS02765	COG2226	methyltransferase
O1G22_RS02795	COG0395	ABC-type sugar transport system, permease component
O1G22_RS02800	COG1175	transmembrane transport
O1G22_RS02820	COG0673	inositol 2-dehydrogenase activity
O1G22_RS02880	COG3250	beta-galactosidase activity
O1G22_RS02895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O1G22_RS02895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O1G22_RS02905	COG1132	(ABC) transporter
O1G22_RS02935	COG0252	asparaginase activity
O1G22_RS02940	COG2610	gluconate transmembrane transporter activity
O1G22_RS02945	COG1473	amidohydrolase
O1G22_RS02965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
O1G22_RS02970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O1G22_RS02985	COG1309	transcriptional regulator
O1G22_RS03005	COG1309	transcriptional regulator
O1G22_RS03025	COG2814	Major facilitator Superfamily
O1G22_RS03045	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS03070	COG4221	oxidoreductase activity
O1G22_RS03080	COG2197	response regulator
O1G22_RS03085	COG4585	Histidine kinase
O1G22_RS03090	COG3963	phosphatidate phosphatase activity
O1G22_RS03145	COG1309	transcriptional regulator
O1G22_RS03185	COG1136	(ABC) transporter
O1G22_RS03185	COG0577	efflux transmembrane transporter activity
O1G22_RS03190	COG1136	(ABC) transporter
O1G22_RS03190	COG0577	efflux transmembrane transporter activity
O1G22_RS03200	COG0789	Transcriptional regulator
O1G22_RS03200	COG4978	Transcriptional regulator
O1G22_RS03250	COG2197	response regulator
O1G22_RS03255	COG4585	Histidine kinase
O1G22_RS03265	COG1396	sequence-specific DNA binding
O1G22_RS03290	COG2015	COG2015, Alkyl sulfatase and related hydrolases
O1G22_RS03295	COG2814	Major facilitator Superfamily
O1G22_RS03330	COG2814	Major facilitator Superfamily
O1G22_RS03355	COG0583	DNA-binding transcription factor activity
O1G22_RS03400	COG0243	molybdopterin cofactor binding
O1G22_RS03425	COG2197	response regulator
O1G22_RS03435	COG2409	Drug exporters of the RND superfamily
O1G22_RS03440	COG0640	Transcriptional regulator
O1G22_RS03470	COG1129	ABC transporter
O1G22_RS03475	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1G22_RS03480	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS03485	COG3618	amidohydrolase
O1G22_RS03495	COG1063	alcohol dehydrogenase
O1G22_RS03500	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS03505	COG0800	Aldolase
O1G22_RS03520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1G22_RS03535	COG2186	Transcriptional regulator
O1G22_RS03545	COG1175	transmembrane transport
O1G22_RS03550	COG0395	ABC-type sugar transport system, permease component
O1G22_RS03565	COG3618	amidohydrolase
O1G22_RS03595	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS03615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O1G22_RS03625	COG1309	transcriptional regulator
O1G22_RS03650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1G22_RS03675	COG1131	(ABC) transporter
O1G22_RS03685	COG2197	response regulator
O1G22_RS03690	COG3485	protocatechuate 3,4-dioxygenase
O1G22_RS03695	COG1454	alcohol dehydrogenase
O1G22_RS03735	COG4977	sequence-specific DNA binding
O1G22_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS03830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1G22_RS03835	COG0542	response to heat
O1G22_RS03840	COG0583	DNA-binding transcription factor activity
O1G22_RS03845	COG3415	Transposase
O1G22_RS03845	COG2801	Transposase and inactivated derivatives
O1G22_RS03850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O1G22_RS03860	COG0303	'Molybdopterin
O1G22_RS03875	COG1597	lipid kinase activity
O1G22_RS03880	COG0277	FAD linked oxidase domain protein
O1G22_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS03910	COG0488	(ABC) transporter
O1G22_RS03925	COG0667	Aldo Keto reductase
O1G22_RS04000	COG3979	chitinase
O1G22_RS04020	COG0702	epimerase
O1G22_RS04040	COG0583	DNA-binding transcription factor activity
O1G22_RS04045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS04050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O1G22_RS04055	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O1G22_RS04075	COG0730	response to heat
O1G22_RS04080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1G22_RS04085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1G22_RS04085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1G22_RS04090	COG2188	Transcriptional regulator
O1G22_RS04100	COG1595	DNA-templated transcription, initiation
O1G22_RS04110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS04115	COG0667	Aldo Keto reductase
O1G22_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS04155	COG0531	amino acid
O1G22_RS04160	COG3537	Alpha-1,2-mannosidase
O1G22_RS04190	COG2267	carboxylic ester hydrolase activity
O1G22_RS04215	COG2837	iron assimilation
O1G22_RS04250	COG1228	amidohydrolase
O1G22_RS04270	COG1595	DNA-templated transcription, initiation
O1G22_RS04310	COG1609	Transcriptional regulator
O1G22_RS04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS04325	COG3718	enzyme involved in inositol metabolism
O1G22_RS04330	COG3962	Belongs to the TPP enzyme family
O1G22_RS04345	COG2814	Major facilitator Superfamily
O1G22_RS04350	COG0673	inositol 2-dehydrogenase activity
O1G22_RS04355	COG1082	Xylose isomerase domain protein TIM barrel
O1G22_RS04390	COG0248	Ppx GppA phosphatase
O1G22_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS04440	COG3469	chitinase activity
O1G22_RS04455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O1G22_RS04485	COG2124	cytochrome p450
O1G22_RS04495	COG0667	Aldo Keto reductase
O1G22_RS04595	COG3290	protein histidine kinase activity
O1G22_RS04615	COG3387	PFAM Glycoside hydrolase 15-related
O1G22_RS04625	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
O1G22_RS04640	COG0586	Pfam SNARE associated Golgi protein
O1G22_RS04650	COG0671	phosphoesterase, PA-phosphatase related
O1G22_RS04655	COG0745	RESPONSE REGULATOR receiver
O1G22_RS04660	COG0642	Histidine kinase
O1G22_RS04675	COG3383	formate dehydrogenase (NAD+) activity
O1G22_RS04680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O1G22_RS04685	COG0569	domain protein
O1G22_RS04715	COG0517	IMP dehydrogenase activity
O1G22_RS04715	COG0516	GMP reductase activity
O1G22_RS04770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1G22_RS04775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O1G22_RS04780	COG0022	dehydrogenase e1 component
O1G22_RS04780	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1G22_RS04785	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1G22_RS04800	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
O1G22_RS04805	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
O1G22_RS04865	COG0589	response to stress
O1G22_RS04870	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
O1G22_RS04920	COG0330	HflC and HflK could
O1G22_RS04945	COG0517	IMP dehydrogenase activity
O1G22_RS04945	COG0617	tRNA 3'-terminal CCA addition
O1G22_RS04945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O1G22_RS04955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O1G22_RS04970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O1G22_RS05020	COG0395	ABC-type sugar transport system, permease component
O1G22_RS05025	COG1175	transmembrane transport
O1G22_RS05080	COG1309	transcriptional regulator
O1G22_RS05090	COG0673	inositol 2-dehydrogenase activity
O1G22_RS05110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O1G22_RS05135	COG1846	Transcriptional regulator
O1G22_RS05135	COG1940	carbohydrate kinase activity
O1G22_RS05190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O1G22_RS05195	COG3345	alpha-galactosidase
O1G22_RS05255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O1G22_RS05285	COG0477	Major facilitator Superfamily
O1G22_RS05305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1G22_RS05315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O1G22_RS05375	COG2274	protein secretion by the type I secretion system
O1G22_RS05415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O1G22_RS05425	COG3250	beta-galactosidase activity
O1G22_RS05435	COG1595	DNA-templated transcription, initiation
O1G22_RS05480	COG0667	Aldo Keto reductase
O1G22_RS05515	COG2124	cytochrome p450
O1G22_RS05545	COG0531	amino acid
O1G22_RS05570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O1G22_RS05575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O1G22_RS05585	COG1796	DNA polymerase
O1G22_RS05585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1G22_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS05625	COG3321	synthase
O1G22_RS05625	COG0604	alcohol dehydrogenase
O1G22_RS05645	COG2706	6-phosphogluconolactonase activity
O1G22_RS05655	COG1309	transcriptional regulator
O1G22_RS05665	COG1357	PFAM Pentapeptide repeats (8 copies)
O1G22_RS05675	COG1819	glycosyl
O1G22_RS05680	COG0789	Transcriptional regulator
O1G22_RS05695	COG1609	Transcriptional regulator
O1G22_RS05720	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1G22_RS05725	COG1129	ABC transporter
O1G22_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS05735	COG3347	Dehydrogenase
O1G22_RS05740	COG1070	Carbohydrate kinase
O1G22_RS05745	COG0247	lactate metabolic process
O1G22_RS05750	COG1139	Iron-sulfur cluster binding protein
O1G22_RS05755	COG1556	Lactate utilization protein
O1G22_RS05775	COG1174	glycine betaine transport
O1G22_RS05780	COG1174	glycine betaine transport
O1G22_RS05790	COG0542	response to heat
O1G22_RS05800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
O1G22_RS05835	COG1765	OsmC-like protein
O1G22_RS05840	COG0277	FAD linked oxidase domain protein
O1G22_RS05865	COG0242	peptide deformylase activity
O1G22_RS05875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1G22_RS05925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O1G22_RS05930	COG0121	glutamine amidotransferase
O1G22_RS05935	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
O1G22_RS05940	COG2182	Extracellular solute-binding protein
O1G22_RS05945	COG3360	Dodecin
O1G22_RS05955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS05980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O1G22_RS05985	COG1053	succinate dehydrogenase
O1G22_RS05995	COG0583	DNA-binding transcription factor activity
O1G22_RS06045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O1G22_RS06045	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O1G22_RS06060	COG0531	amino acid
O1G22_RS06085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1G22_RS06105	COG3618	amidohydrolase
O1G22_RS06125	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS06135	COG1129	ABC transporter
O1G22_RS06145	COG2186	Transcriptional regulator
O1G22_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS06185	COG3537	Alpha-1,2-mannosidase
O1G22_RS06190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O1G22_RS06195	COG0297	glycogen (starch) synthase activity
O1G22_RS06215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O1G22_RS06225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O1G22_RS06245	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1G22_RS06245	COG1902	pentaerythritol trinitrate reductase activity
O1G22_RS06280	COG3275	phosphorelay sensor kinase activity
O1G22_RS06285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1G22_RS06305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O1G22_RS06310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
O1G22_RS06315	COG2080	2 iron, 2 sulfur cluster binding
O1G22_RS06325	COG1132	(ABC) transporter
O1G22_RS06335	COG1024	Enoyl-CoA hydratase
O1G22_RS06350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O1G22_RS06360	COG0531	amino acid
O1G22_RS06365	COG0668	transmembrane transport
O1G22_RS06370	COG2838	Isocitrate dehydrogenase
O1G22_RS06380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O1G22_RS06390	COG2124	cytochrome p450
O1G22_RS06415	COG2197	response regulator
O1G22_RS06425	COG0477	Major facilitator Superfamily
O1G22_RS06435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS06445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS06450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS06455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS06465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1G22_RS06470	COG1126	abc transporter atp-binding protein
O1G22_RS06510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1G22_RS06515	COG3938	Belongs to the proline racemase family
O1G22_RS06530	COG0531	amino acid
O1G22_RS06560	COG0477	Major facilitator Superfamily
O1G22_RS06580	COG1609	Transcriptional regulator
O1G22_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS06595	COG0673	inositol 2-dehydrogenase activity
O1G22_RS06625	COG2188	Transcriptional regulator
O1G22_RS06630	COG1653	transport
O1G22_RS06640	COG0395	ABC-type sugar transport system, permease component
O1G22_RS06665	COG2197	response regulator
O1G22_RS06720	COG1011	Hydrolase
O1G22_RS06730	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS06735	COG0183	Belongs to the thiolase family
O1G22_RS06790	COG3959	Transketolase, thiamine diphosphate binding domain
O1G22_RS06795	COG3958	Transketolase
O1G22_RS06820	COG0583	DNA-binding transcription factor activity
O1G22_RS06825	COG0156	8-amino-7-oxononanoate synthase activity
O1G22_RS06830	COG1063	alcohol dehydrogenase
O1G22_RS06875	COG2755	lipolytic protein G-D-S-L family
O1G22_RS06890	COG2365	Tyrosine phosphatase family
O1G22_RS06915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O1G22_RS06920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O1G22_RS06935	COG1657	PFAM Prenyltransferase squalene oxidase
O1G22_RS06945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O1G22_RS06955	COG1562	ergosterol biosynthetic process
O1G22_RS06960	COG1134	teichoic acid transport
O1G22_RS07000	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
O1G22_RS07010	COG1024	Enoyl-CoA hydratase
O1G22_RS07020	COG4977	sequence-specific DNA binding
O1G22_RS07030	COG2183	response to ionizing radiation
O1G22_RS07035	COG2318	DinB family
O1G22_RS07040	COG0488	(ABC) transporter
O1G22_RS07055	COG2936	dipeptidyl-peptidase activity
O1G22_RS07065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS07075	COG1113	amino acid transport
O1G22_RS07085	COG1024	Enoyl-CoA hydratase
O1G22_RS07085	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1G22_RS07090	COG0183	Belongs to the thiolase family
O1G22_RS07095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O1G22_RS07100	COG3268	Saccharopine dehydrogenase
O1G22_RS07110	COG1515	deoxyribonuclease V activity
O1G22_RS07130	COG0488	(ABC) transporter
O1G22_RS07135	COG1834	amidinotransferase
O1G22_RS07170	COG1793	dna ligase
O1G22_RS07200	COG3485	protocatechuate 3,4-dioxygenase
O1G22_RS07205	COG3485	protocatechuate 3,4-dioxygenase
O1G22_RS07210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O1G22_RS07215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS07255	COG3511	phospholipase C
O1G22_RS07260	COG0326	Molecular chaperone. Has ATPase activity
O1G22_RS07310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O1G22_RS07325	COG1486	melibiose metabolic process
O1G22_RS07335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS07355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O1G22_RS07360	COG3250	beta-galactosidase activity
O1G22_RS07365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O1G22_RS07395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O1G22_RS07410	COG0166	Belongs to the GPI family
O1G22_RS07415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O1G22_RS07420	COG0588	phosphoglycerate mutase activity
O1G22_RS07430	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O1G22_RS07430	COG1082	Xylose isomerase domain protein TIM barrel
O1G22_RS07435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O1G22_RS07445	COG0477	Major facilitator Superfamily
O1G22_RS07485	COG2084	Dehydrogenase
O1G22_RS07490	COG3467	pyridoxamine 5'-phosphate
O1G22_RS07500	COG0477	Major facilitator Superfamily
O1G22_RS07510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1G22_RS07530	COG0297	glycogen (starch) synthase activity
O1G22_RS07565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O1G22_RS07575	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1G22_RS07580	COG1129	ABC transporter
O1G22_RS07585	COG1609	Transcriptional regulator
O1G22_RS07595	COG0393	Putative heavy-metal-binding
O1G22_RS07605	COG0405	Gamma-glutamyltransferase
O1G22_RS07615	COG1063	alcohol dehydrogenase
O1G22_RS07630	COG1609	Transcriptional regulator
O1G22_RS07635	COG0515	serine threonine protein kinase
O1G22_RS07635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS07695	COG0326	Molecular chaperone. Has ATPase activity
O1G22_RS07715	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
O1G22_RS07720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
O1G22_RS07735	COG3537	Alpha-1,2-mannosidase
O1G22_RS07765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O1G22_RS07835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1G22_RS07855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O1G22_RS07860	COG0583	DNA-binding transcription factor activity
O1G22_RS07865	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS07875	COG1846	Transcriptional regulator
O1G22_RS07895	COG0583	DNA-binding transcription factor activity
O1G22_RS07920	COG2890	protein-(glutamine-N5) methyltransferase activity
O1G22_RS07925	COG5297	Belongs to the glycosyl hydrolase family 6
O1G22_RS07935	COG4733	cellulase activity
O1G22_RS07935	COG5297	Belongs to the glycosyl hydrolase family 6
O1G22_RS07945	COG2226	methyltransferase
O1G22_RS07950	COG2154	pterin-4-alpha-carbinolamine dehydratase
O1G22_RS07985	COG0443	Heat shock 70 kDa protein
O1G22_RS08005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O1G22_RS08030	COG0488	(ABC) transporter
O1G22_RS08035	COG0406	alpha-ribazole phosphatase activity
O1G22_RS08070	COG1619	proteins homologs of microcin C7 resistance protein MccF
O1G22_RS08080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1G22_RS08085	COG2362	D-Aminopeptidase
O1G22_RS08100	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
O1G22_RS08115	COG2208	phosphoserine phosphatase activity
O1G22_RS08115	COG1366	Belongs to the anti-sigma-factor antagonist family
O1G22_RS08115	COG2172	sigma factor antagonist activity
O1G22_RS08145	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1G22_RS08160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS08160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS08175	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS08180	COG0688	phosphatidylethanolamine metabolic process
O1G22_RS08195	COG1929	Belongs to the glycerate kinase type-1 family
O1G22_RS08205	COG0494	nUDIX hydrolase
O1G22_RS08210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O1G22_RS08290	COG0483	inositol monophosphate 1-phosphatase activity
O1G22_RS08300	COG0095	Lipoate-protein ligase
O1G22_RS08350	COG1953	Uracil, thiamine, allantoin
O1G22_RS08360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O1G22_RS08375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1G22_RS08400	COG0542	response to heat
O1G22_RS08405	COG0405	Gamma-glutamyltransferase
O1G22_RS08420	COG0765	amino acid transport
O1G22_RS08425	COG0765	amino acid transport
O1G22_RS08430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1G22_RS08435	COG1126	abc transporter atp-binding protein
O1G22_RS08450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O1G22_RS08455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS08465	COG3328	transposase activity
O1G22_RS08565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O1G22_RS08580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1G22_RS08585	COG0577	efflux transmembrane transporter activity
O1G22_RS08585	COG1136	(ABC) transporter
O1G22_RS08610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O1G22_RS08670	COG0523	cobalamin synthesis protein
O1G22_RS08685	COG0640	Transcriptional regulator
O1G22_RS08705	COG0803	Belongs to the bacterial solute-binding protein 9 family
O1G22_RS08710	COG1121	(ABC) transporter
O1G22_RS08745	COG0523	cobalamin synthesis protein
O1G22_RS08780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1G22_RS08790	COG1940	carbohydrate kinase activity
O1G22_RS08810	COG2188	Transcriptional regulator
O1G22_RS08830	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1G22_RS08830	COG0567	Dehydrogenase, E1 component
O1G22_RS08875	COG2124	cytochrome p450
O1G22_RS08890	COG0604	alcohol dehydrogenase
O1G22_RS08890	COG3321	synthase
O1G22_RS08915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1G22_RS08945	COG4266	Belongs to the allantoicase family
O1G22_RS08950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O1G22_RS08955	COG1414	Transcriptional regulator
O1G22_RS08970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O1G22_RS08980	COG4213	ABC transporter substrate-binding protein
O1G22_RS08990	COG4213	ABC transporter substrate-binding protein
O1G22_RS09000	COG4214	carbohydrate transport
O1G22_RS09015	COG2017	converts alpha-aldose to the beta-anomer
O1G22_RS09035	COG1609	Transcriptional regulator
O1G22_RS09045	COG0180	Tryptophanyl-tRNA synthetase
O1G22_RS09055	COG4264	IucA IucC family
O1G22_RS09070	COG1733	regulation of RNA biosynthetic process
O1G22_RS09075	COG0436	Aminotransferase
O1G22_RS09080	COG0604	alcohol dehydrogenase
O1G22_RS09080	COG3321	synthase
O1G22_RS09085	COG2409	Drug exporters of the RND superfamily
O1G22_RS09105	COG0406	alpha-ribazole phosphatase activity
O1G22_RS09115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O1G22_RS09120	COG1733	regulation of RNA biosynthetic process
O1G22_RS09140	COG3548	integral membrane protein
O1G22_RS09145	COG2233	PERMEase
O1G22_RS09155	COG2233	PERMEase
O1G22_RS09165	COG2351	hydroxyisourate hydrolase activity
O1G22_RS09185	COG1366	Belongs to the anti-sigma-factor antagonist family
O1G22_RS09185	COG2172	sigma factor antagonist activity
O1G22_RS09185	COG2208	phosphoserine phosphatase activity
O1G22_RS09205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O1G22_RS09220	COG0535	radical SAM domain protein
O1G22_RS09230	COG3622	Belongs to the hyi family
O1G22_RS09235	COG2084	Dehydrogenase
O1G22_RS09240	COG0753	catalase activity
O1G22_RS09250	COG3960	tartronate-semialdehyde synthase activity
O1G22_RS09260	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS09265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1G22_RS09270	COG2197	response regulator
O1G22_RS09290	COG1653	transport
O1G22_RS09320	COG0726	polysaccharide deacetylase
O1G22_RS09340	COG2252	PERMEase
O1G22_RS09345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O1G22_RS09360	COG3835	regulator
O1G22_RS09370	COG1802	Transcriptional regulator
O1G22_RS09385	COG0028	Belongs to the TPP enzyme family
O1G22_RS09420	COG1162	GTPase activity
O1G22_RS09460	COG1940	carbohydrate kinase activity
O1G22_RS09490	COG1131	(ABC) transporter
O1G22_RS09530	COG2755	lipolytic protein G-D-S-L family
O1G22_RS09560	COG2040	homocysteine
O1G22_RS09565	COG1609	Transcriptional regulator
O1G22_RS09590	COG0395	ABC-type sugar transport system, permease component
O1G22_RS09595	COG1175	transmembrane transport
O1G22_RS09625	COG1175	transmembrane transport
O1G22_RS09630	COG0395	ABC-type sugar transport system, permease component
O1G22_RS09655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O1G22_RS09685	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS09715	COG0175	sulfate reduction
O1G22_RS09720	COG0529	Catalyzes the synthesis of activated sulfate
O1G22_RS09740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
O1G22_RS09745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1G22_RS09760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1G22_RS09765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O1G22_RS09845	COG1716	ATPase activity
O1G22_RS09855	COG3173	Aminoglycoside phosphotransferase
O1G22_RS09890	COG0596	Alpha beta hydrolase
O1G22_RS09925	COG0640	Transcriptional regulator
O1G22_RS09935	COG1732	Glycine betaine
O1G22_RS09940	COG5002	protein histidine kinase activity
O1G22_RS09945	COG2018	Roadblock/LC7 domain
O1G22_RS09960	COG1174	glycine betaine transport
O1G22_RS09965	COG1174	glycine betaine transport
O1G22_RS09990	COG0745	RESPONSE REGULATOR receiver
O1G22_RS09995	COG2205	protein histidine kinase activity
O1G22_RS10010	COG1401	restriction endodeoxyribonuclease activity
O1G22_RS10040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1G22_RS10045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O1G22_RS10080	COG0330	HflC and HflK could
O1G22_RS10085	COG1881	PFAM PEBP family protein
O1G22_RS10100	COG4152	abc transporter atp-binding protein
O1G22_RS10120	COG3220	belongs to the UPF0276 family
O1G22_RS10135	COG0596	Alpha beta hydrolase
O1G22_RS10140	COG3253	May function as heme-dependent peroxidase
O1G22_RS10145	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O1G22_RS10155	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1G22_RS10170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O1G22_RS10185	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
O1G22_RS10190	COG0395	ABC-type sugar transport system, permease component
O1G22_RS10195	COG1175	transmembrane transport
O1G22_RS10205	COG3250	beta-galactosidase activity
O1G22_RS10210	COG1609	Transcriptional regulator
O1G22_RS10215	COG0183	Belongs to the thiolase family
O1G22_RS10220	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1G22_RS10220	COG1024	Enoyl-CoA hydratase
O1G22_RS10230	COG0531	amino acid
O1G22_RS10235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O1G22_RS10240	COG4214	carbohydrate transport
O1G22_RS10250	COG4213	ABC transporter substrate-binding protein
O1G22_RS10255	COG1940	carbohydrate kinase activity
O1G22_RS10260	COG0395	ABC-type sugar transport system, permease component
O1G22_RS10265	COG1175	transmembrane transport
O1G22_RS10270	COG1653	transport
O1G22_RS10285	COG2205	protein histidine kinase activity
O1G22_RS10290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O1G22_RS10295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1G22_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS10320	COG0667	Aldo Keto reductase
O1G22_RS10335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
O1G22_RS10340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
O1G22_RS10345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
O1G22_RS10385	COG0583	DNA-binding transcription factor activity
O1G22_RS10405	COG1472	Belongs to the glycosyl hydrolase 3 family
O1G22_RS10410	COG0395	ABC-type sugar transport system, permease component
O1G22_RS10415	COG1175	transmembrane transport
O1G22_RS10420	COG2182	Extracellular solute-binding protein
O1G22_RS10425	COG2188	Transcriptional regulator
O1G22_RS10480	COG1024	Enoyl-CoA hydratase
O1G22_RS10490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O1G22_RS10495	COG2235	arginine
O1G22_RS10510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O1G22_RS10555	COG1799	cell septum assembly
O1G22_RS10565	COG2353	YceI-like domain
O1G22_RS10600	COG0542	response to heat
O1G22_RS10610	COG0584	glycerophosphoryl diester phosphodiesterase
O1G22_RS10620	COG0583	DNA-binding transcription factor activity
O1G22_RS10650	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1G22_RS10665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1G22_RS10675	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1G22_RS10720	COG0321	lipoyl(octanoyl) transferase activity
O1G22_RS10730	COG2267	carboxylic ester hydrolase activity
O1G22_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS10820	COG0667	Aldo Keto reductase
O1G22_RS10825	COG1309	transcriptional regulator
O1G22_RS10830	COG3608	succinylglutamate desuccinylase aspartoacylase
O1G22_RS10830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O1G22_RS10835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O1G22_RS10840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
O1G22_RS10845	COG2080	2 iron, 2 sulfur cluster binding
O1G22_RS10850	COG1064	alcohol dehydrogenase
O1G22_RS10885	COG0655	NAD(P)H dehydrogenase (quinone) activity
O1G22_RS10895	COG1063	alcohol dehydrogenase
O1G22_RS10960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1G22_RS10965	COG0531	amino acid
O1G22_RS10975	COG0569	domain protein
O1G22_RS11010	COG0756	dUTP diphosphatase activity
O1G22_RS11035	COG2205	protein histidine kinase activity
O1G22_RS11040	COG0745	RESPONSE REGULATOR receiver
O1G22_RS11055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O1G22_RS11090	COG1435	thymidine kinase activity
O1G22_RS11115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1G22_RS11120	COG1802	Transcriptional regulator
O1G22_RS11135	COG0612	Peptidase, M16
O1G22_RS11140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O1G22_RS11150	COG0372	Belongs to the citrate synthase family
O1G22_RS11165	COG3290	protein histidine kinase activity
O1G22_RS11170	COG4565	transcriptional regulatory protein
O1G22_RS11180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1G22_RS11195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1G22_RS11205	COG2197	response regulator
O1G22_RS11220	COG0187	DNA topoisomerase II activity
O1G22_RS11250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O1G22_RS11255	COG1802	Transcriptional regulator
O1G22_RS11295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O1G22_RS11315	COG0588	phosphoglycerate mutase activity
O1G22_RS11330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1G22_RS11335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O1G22_RS11340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O1G22_RS11370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O1G22_RS11380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1G22_RS11385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O1G22_RS11395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O1G22_RS11415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O1G22_RS11440	COG3345	alpha-galactosidase
O1G22_RS11465	COG2358	TRAP transporter, solute receptor (TAXI family
O1G22_RS11470	COG2205	protein histidine kinase activity
O1G22_RS11475	COG0745	RESPONSE REGULATOR receiver
O1G22_RS11480	COG1126	abc transporter atp-binding protein
O1G22_RS11485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1G22_RS11490	COG0765	amino acid transport
O1G22_RS11495	COG0765	amino acid transport
O1G22_RS11525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O1G22_RS11545	COG0142	geranyltranstransferase activity
O1G22_RS11560	COG0628	permease
O1G22_RS11575	COG2197	response regulator
O1G22_RS11615	COG2814	Major facilitator Superfamily
O1G22_RS11620	COG1846	Transcriptional regulator
O1G22_RS11635	COG2226	methyltransferase
O1G22_RS11670	COG1201	RNA secondary structure unwinding
O1G22_RS11675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1G22_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS11690	COG0783	Belongs to the Dps family
O1G22_RS11695	COG1396	sequence-specific DNA binding
O1G22_RS11700	COG1058	Belongs to the CinA family
O1G22_RS11700	COG1546	Belongs to the CinA family
O1G22_RS11710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O1G22_RS11720	COG1674	ftsk spoiiie
O1G22_RS11730	COG0784	Response regulator, receiver
O1G22_RS11730	COG2205	protein histidine kinase activity
O1G22_RS11735	COG2770	Histidine kinase
O1G22_RS11735	COG2208	phosphoserine phosphatase activity
O1G22_RS11765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O1G22_RS11770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1G22_RS11775	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
O1G22_RS11795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O1G22_RS11800	COG0612	Peptidase, M16
O1G22_RS11805	COG1185	polyribonucleotide nucleotidyltransferase activity
O1G22_RS11810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O1G22_RS11825	COG1674	ftsk spoiiie
O1G22_RS11830	COG0515	serine threonine protein kinase
O1G22_RS11830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS11835	COG0515	serine threonine protein kinase
O1G22_RS11835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS11855	COG1404	Belongs to the peptidase S8 family
O1G22_RS11930	COG3266	domain, Protein
O1G22_RS11945	COG0455	bacterial-type flagellum organization
O1G22_RS11960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O1G22_RS11965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O1G22_RS11975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O1G22_RS11990	COG0779	Required for maturation of 30S ribosomal subunits
O1G22_RS12010	COG0442	prolyl-tRNA aminoacylation
O1G22_RS12015	COG1247	-acetyltransferase
O1G22_RS12040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O1G22_RS12055	COG0750	zinc metalloprotease
O1G22_RS12060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O1G22_RS12085	COG1605	Chorismate mutase
O1G22_RS12105	COG4447	cellulose binding
O1G22_RS12115	COG0395	ABC-type sugar transport system, permease component
O1G22_RS12120	COG4209	transmembrane transport
O1G22_RS12130	COG1472	Belongs to the glycosyl hydrolase 3 family
O1G22_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS12145	COG2508	Transcriptional regulator
O1G22_RS12175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1G22_RS12180	COG1177	transmembrane transport
O1G22_RS12185	COG1176	ABC-type spermidine putrescine transport system, permease component I
O1G22_RS12190	COG3842	ATPase activity
O1G22_RS12215	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1G22_RS12220	COG0584	glycerophosphoryl diester phosphodiesterase
O1G22_RS12250	COG0702	epimerase
O1G22_RS12260	COG1309	transcriptional regulator
O1G22_RS12270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1G22_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS12290	COG1595	DNA-templated transcription, initiation
O1G22_RS12300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O1G22_RS12325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS12335	COG0657	acetylesterase activity
O1G22_RS12350	COG2814	Major facilitator Superfamily
O1G22_RS12365	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS12375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1G22_RS12400	COG3842	ATPase activity
O1G22_RS12405	COG4208	sulfate ABC transporter
O1G22_RS12415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O1G22_RS12420	COG2353	YceI-like domain
O1G22_RS12425	COG0575	Belongs to the CDS family
O1G22_RS12430	COG0233	cytoplasmic translational termination
O1G22_RS12435	COG0528	UMP kinase activity
O1G22_RS12440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O1G22_RS12445	COG0052	Belongs to the universal ribosomal protein uS2 family
O1G22_RS12450	COG4942	peptidase
O1G22_RS12460	COG1191	sigma factor activity
O1G22_RS12475	COG0792	nuclease activity
O1G22_RS12495	COG0681	Belongs to the peptidase S26 family
O1G22_RS12500	COG0681	Belongs to the peptidase S26 family
O1G22_RS12510	COG0335	large ribosomal subunit rRNA binding
O1G22_RS12515	COG0336	Belongs to the RNA methyltransferase TrmD family
O1G22_RS12520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O1G22_RS12525	COG1837	Belongs to the UPF0109 family
O1G22_RS12530	COG0228	four-way junction DNA binding
O1G22_RS12545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1G22_RS12555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O1G22_RS12585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1G22_RS12595	COG0477	Major facilitator Superfamily
O1G22_RS12600	COG1196	nuclear chromosome segregation
O1G22_RS12610	COG1254	Belongs to the acylphosphatase family
O1G22_RS12615	COG2340	Cysteine-rich secretory protein family
O1G22_RS12630	COG0655	NAD(P)H dehydrogenase (quinone) activity
O1G22_RS12635	COG1733	regulation of RNA biosynthetic process
O1G22_RS12640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1G22_RS12645	COG0571	ribonuclease III activity
O1G22_RS12650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O1G22_RS12665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O1G22_RS12670	COG0742	ribosomal rna small subunit methyltransferase
O1G22_RS12680	COG0326	Molecular chaperone. Has ATPase activity
O1G22_RS12695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O1G22_RS12700	COG0351	phosphomethylpyrimidine kinase
O1G22_RS12720	COG1181	Belongs to the D-alanine--D-alanine ligase family
O1G22_RS12725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O1G22_RS12735	COG1920	GTP binding
O1G22_RS12745	COG0776	regulation of translation
O1G22_RS12755	COG0066	3-isopropylmalate dehydratase activity
O1G22_RS12760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O1G22_RS12765	COG1414	Transcriptional regulator
O1G22_RS12815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1G22_RS12820	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1G22_RS12830	COG5002	protein histidine kinase activity
O1G22_RS12835	COG2018	Roadblock/LC7 domain
O1G22_RS12855	COG2018	Roadblock/LC7 domain
O1G22_RS12880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1G22_RS12885	COG5492	domain, Protein
O1G22_RS12890	COG2353	YceI-like domain
O1G22_RS12930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1G22_RS12935	COG0477	Major facilitator Superfamily
O1G22_RS12950	COG2957	Belongs to the agmatine deiminase family
O1G22_RS12955	COG0804	urea catabolic process
O1G22_RS12960	COG0831	urea catabolic process
O1G22_RS12960	COG0832	Belongs to the urease beta subunit family
O1G22_RS12970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O1G22_RS12975	COG0473	3-isopropylmalate dehydrogenase activity
O1G22_RS12990	COG2130	NADP-dependent
O1G22_RS13005	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS13010	COG0506	proline dehydrogenase activity
O1G22_RS13020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1G22_RS13035	COG0477	Major facilitator Superfamily
O1G22_RS13040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1G22_RS13045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O1G22_RS13050	COG0440	acetolactate synthase activity
O1G22_RS13060	COG5001	Diguanylate cyclase
O1G22_RS13070	COG0667	Aldo Keto reductase
O1G22_RS13075	COG2133	pyrroloquinoline quinone binding
O1G22_RS13085	COG2197	response regulator
O1G22_RS13100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1G22_RS13105	COG2409	Drug exporters of the RND superfamily
O1G22_RS13115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O1G22_RS13125	COG0154	amidase activity
O1G22_RS13130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O1G22_RS13155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O1G22_RS13165	COG4221	oxidoreductase activity
O1G22_RS13170	COG1611	Belongs to the LOG family
O1G22_RS13185	COG0482	sulfurtransferase activity
O1G22_RS13215	COG2378	regulation of single-species biofilm formation
O1G22_RS13245	COG2860	membrane
O1G22_RS13255	COG4608	Belongs to the ABC transporter superfamily
O1G22_RS13260	COG0444	Belongs to the ABC transporter superfamily
O1G22_RS13270	COG0747	negative chemotaxis
O1G22_RS13275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1G22_RS13295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O1G22_RS13300	COG0509	glycine decarboxylation via glycine cleavage system
O1G22_RS13305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O1G22_RS13310	COG1760	l-serine dehydratase
O1G22_RS13320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O1G22_RS13350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1G22_RS13370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1G22_RS13380	COG0789	Transcriptional regulator
O1G22_RS13405	COG1024	Enoyl-CoA hydratase
O1G22_RS13410	COG1376	ErfK ybiS ycfS ynhG family protein
O1G22_RS13420	COG2197	response regulator
O1G22_RS13425	COG4585	Histidine kinase
O1G22_RS13435	COG1131	(ABC) transporter
O1G22_RS13440	COG1132	(ABC) transporter
O1G22_RS13445	COG1132	(ABC) transporter
O1G22_RS13455	COG1132	(ABC) transporter
O1G22_RS13460	COG1132	(ABC) transporter
O1G22_RS13500	COG0058	SHG alpha-glucan phosphorylase activity
O1G22_RS13505	COG0366	Alpha amylase catalytic
O1G22_RS13515	COG3281	Trehalose synthase
O1G22_RS13520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O1G22_RS13545	COG0477	Major facilitator Superfamily
O1G22_RS13555	COG1301	dicarboxylic acid transport
O1G22_RS13560	COG3290	protein histidine kinase activity
O1G22_RS13565	COG4565	transcriptional regulatory protein
O1G22_RS13575	COG1175	transmembrane transport
O1G22_RS13580	COG0395	ABC-type sugar transport system, permease component
O1G22_RS13590	COG0205	6-phosphofructokinase activity
O1G22_RS13595	COG0857	belongs to the CobB CobQ family
O1G22_RS13595	COG0280	phosphate acetyltransferase
O1G22_RS13600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O1G22_RS13645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS13645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS13710	COG0183	Belongs to the thiolase family
O1G22_RS13730	COG1131	(ABC) transporter
O1G22_RS13790	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
O1G22_RS13805	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1G22_RS13860	COG2205	protein histidine kinase activity
O1G22_RS13885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O1G22_RS13890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O1G22_RS13895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O1G22_RS13900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O1G22_RS13905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1G22_RS13910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O1G22_RS13915	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1G22_RS13935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O1G22_RS13940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1G22_RS13950	COG2890	protein-(glutamine-N5) methyltransferase activity
O1G22_RS13955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O1G22_RS13960	COG0254	rRNA binding
O1G22_RS13975	COG0083	homoserine kinase activity
O1G22_RS13980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O1G22_RS13985	COG0460	homoserine dehydrogenase
O1G22_RS13990	COG0019	diaminopimelate decarboxylase activity
O1G22_RS13995	COG0018	arginyl-trna synthetase
O1G22_RS13995	COG0018	arginyl-trna synthetase
O1G22_RS14010	COG3328	transposase activity
O1G22_RS14020	COG1309	transcriptional regulator
O1G22_RS14035	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O1G22_RS14040	COG1793	dna ligase
O1G22_RS14040	COG3285	dna ligase
O1G22_RS14060	COG2205	protein histidine kinase activity
O1G22_RS14065	COG0772	Belongs to the SEDS family
O1G22_RS14105	COG0791	NLP P60 protein
O1G22_RS14105	COG3883	PFAM NLP P60 protein
O1G22_RS14175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O1G22_RS14190	COG0745	RESPONSE REGULATOR receiver
O1G22_RS14195	COG2205	protein histidine kinase activity
O1G22_RS14200	COG0567	Dehydrogenase, E1 component
O1G22_RS14200	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1G22_RS14225	COG2255	four-way junction helicase activity
O1G22_RS14255	COG0542	response to heat
O1G22_RS14265	COG0604	alcohol dehydrogenase
O1G22_RS14270	COG0281	malic enzyme
O1G22_RS14285	COG1126	abc transporter atp-binding protein
O1G22_RS14290	COG4106	trans-aconitate 2-methyltransferase activity
O1G22_RS14385	COG0142	geranyltranstransferase activity
O1G22_RS14390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1G22_RS14400	COG2515	1-aminocyclopropane-1-carboxylate deaminase
O1G22_RS14415	COG2172	sigma factor antagonist activity
O1G22_RS14430	COG1597	lipid kinase activity
O1G22_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS14455	COG0363	glucosamine-6-phosphate deaminase activity
O1G22_RS14460	COG2188	Transcriptional regulator
O1G22_RS14485	COG2124	cytochrome p450
O1G22_RS14495	COG0242	peptide deformylase activity
O1G22_RS14515	COG5662	AntiSigma factor
O1G22_RS14520	COG1595	DNA-templated transcription, initiation
O1G22_RS14530	COG2135	peptidase activity
O1G22_RS14540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O1G22_RS14545	COG1162	GTPase activity
O1G22_RS14550	COG2076	Multidrug Resistance protein
O1G22_RS14565	COG0483	inositol monophosphate 1-phosphatase activity
O1G22_RS14575	COG0753	catalase activity
O1G22_RS14600	COG1615	UPF0182 protein
O1G22_RS14610	COG3480	Lon protease (S16) C-terminal proteolytic domain
O1G22_RS14665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O1G22_RS14705	COG2816	NAD+ diphosphatase activity
O1G22_RS14715	COG0210	DNA helicase
O1G22_RS14790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1G22_RS14795	COG0747	negative chemotaxis
O1G22_RS14835	COG0513	Belongs to the DEAD box helicase family
O1G22_RS14855	COG1432	Conserved Protein
O1G22_RS14865	COG2095	MarC family integral membrane protein
O1G22_RS14885	COG0598	Magnesium transport protein CorA
O1G22_RS14900	COG2239	Acts as a magnesium transporter
O1G22_RS14920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1G22_RS14925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1G22_RS14935	COG1595	DNA-templated transcription, initiation
O1G22_RS14950	COG1024	Enoyl-CoA hydratase
O1G22_RS14955	COG0519	Catalyzes the synthesis of GMP from XMP
O1G22_RS14970	COG1611	Belongs to the LOG family
O1G22_RS14975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1G22_RS15010	COG2197	response regulator
O1G22_RS15015	COG4585	Histidine kinase
O1G22_RS15025	COG1131	(ABC) transporter
O1G22_RS15040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1G22_RS15055	COG4608	Belongs to the ABC transporter superfamily
O1G22_RS15060	COG0444	Belongs to the ABC transporter superfamily
O1G22_RS15070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1G22_RS15075	COG0601	transmembrane transport
O1G22_RS15080	COG4166	transmembrane transport
O1G22_RS15085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1G22_RS15090	COG0747	negative chemotaxis
O1G22_RS15095	COG0601	transmembrane transport
O1G22_RS15100	COG0444	Belongs to the ABC transporter superfamily
O1G22_RS15105	COG4608	Belongs to the ABC transporter superfamily
O1G22_RS15140	COG1595	DNA-templated transcription, initiation
O1G22_RS15145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS15160	COG4608	Belongs to the ABC transporter superfamily
O1G22_RS15165	COG0444	Belongs to the ABC transporter superfamily
O1G22_RS15170	COG0601	transmembrane transport
O1G22_RS15175	COG0747	negative chemotaxis
O1G22_RS15180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1G22_RS15185	COG1217	gtp-binding protein TYPA
O1G22_RS15205	COG1053	succinate dehydrogenase
O1G22_RS15210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O1G22_RS15290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1G22_RS15310	COG0012	GTP binding
O1G22_RS15325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O1G22_RS15335	COG1570	exodeoxyribonuclease VII activity
O1G22_RS15340	COG1722	exodeoxyribonuclease VII activity
O1G22_RS15345	COG0778	Nitroreductase
O1G22_RS15370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
O1G22_RS15370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
O1G22_RS15385	COG0114	fumarate hydratase activity
O1G22_RS15400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1G22_RS15410	COG1136	(ABC) transporter
O1G22_RS15425	COG0450	alkyl hydroperoxide reductase
O1G22_RS15430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS15440	COG0741	lytic transglycosylase activity
O1G22_RS15445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O1G22_RS15450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1G22_RS15460	COG2318	DinB family
O1G22_RS15465	COG0590	tRNA wobble adenosine to inosine editing
O1G22_RS15465	COG0037	tRNA processing
O1G22_RS15485	COG2885	chlorophyll binding
O1G22_RS15505	COG2197	response regulator
O1G22_RS15510	COG3920	Histidine kinase
O1G22_RS15540	COG2894	cell division
O1G22_RS15585	COG0251	oxidation-reduction process
O1G22_RS15590	COG1414	Transcriptional regulator
O1G22_RS15605	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
O1G22_RS15620	COG0436	Aminotransferase
O1G22_RS15630	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
O1G22_RS15640	COG0477	Major facilitator Superfamily
O1G22_RS15645	COG1309	transcriptional regulator
O1G22_RS15675	COG1331	Highly conserved protein containing a thioredoxin domain
O1G22_RS15690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O1G22_RS15700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1G22_RS15715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O1G22_RS15720	COG2255	four-way junction helicase activity
O1G22_RS15725	COG1595	DNA-templated transcription, initiation
O1G22_RS15745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1G22_RS15785	COG1064	alcohol dehydrogenase
O1G22_RS15800	COG1136	(ABC) transporter
O1G22_RS15830	COG2986	histidine ammonia-lyase
O1G22_RS15840	COG1024	Enoyl-CoA hydratase
O1G22_RS15850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
O1G22_RS15860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1G22_RS15875	COG0424	maF-like protein
O1G22_RS15885	COG4770	biotin carboxylase activity
O1G22_RS15910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1G22_RS15920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O1G22_RS15925	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS15945	COG1595	DNA-templated transcription, initiation
O1G22_RS15950	COG0745	RESPONSE REGULATOR receiver
O1G22_RS15955	COG2205	protein histidine kinase activity
O1G22_RS15980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1G22_RS16020	COG0583	DNA-binding transcription factor activity
O1G22_RS16025	COG2814	Major facilitator Superfamily
O1G22_RS16030	COG0592	DNA-directed DNA polymerase activity
O1G22_RS16055	COG1079	Belongs to the binding-protein-dependent transport system permease family
O1G22_RS16060	COG4603	Belongs to the binding-protein-dependent transport system permease family
O1G22_RS16065	COG3845	ABC transporter
O1G22_RS16070	COG1744	ABC transporter substrate-binding protein PnrA-like
O1G22_RS16075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O1G22_RS16075	COG1473	amidohydrolase
O1G22_RS16115	COG2089	acid synthase
O1G22_RS16130	COG1216	Glycosyl transferase, family 2
O1G22_RS16140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O1G22_RS16150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS16150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS16165	COG1595	DNA-templated transcription, initiation
O1G22_RS16190	COG3525	Glycosyl hydrolase, family 20, catalytic domain
O1G22_RS16200	COG2009	succinate dehydrogenase
O1G22_RS16210	COG1053	succinate dehydrogenase
O1G22_RS16225	COG1309	transcriptional regulator
O1G22_RS16250	COG1295	ribonuclease BN
O1G22_RS16270	COG0180	Tryptophanyl-tRNA synthetase
O1G22_RS16280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O1G22_RS16285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1G22_RS16300	COG0754	glutathionylspermidine amidase activity
O1G22_RS16315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1G22_RS16320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS16325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS16340	COG4176	ABC-type proline glycine betaine transport system permease component
O1G22_RS16345	COG0517	IMP dehydrogenase activity
O1G22_RS16345	COG4175	Glycine betaine
O1G22_RS16355	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS16365	COG1846	Transcriptional regulator
O1G22_RS16365	COG0456	acetyltransferase
O1G22_RS16370	COG0300	oxidoreductase activity
O1G22_RS16380	COG0039	L-malate dehydrogenase activity
O1G22_RS16395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O1G22_RS16440	COG0138	bifunctional purine biosynthesis protein purh
O1G22_RS16490	COG0045	succinate-CoA ligase (ADP-forming) activity
O1G22_RS16505	COG3552	Protein containing von Willebrand factor type A (VWA) domain
O1G22_RS16510	COG2425	protein containing a von Willebrand factor type A (vWA) domain
O1G22_RS16515	COG0714	Associated with various cellular activities
O1G22_RS16530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS16530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
O1G22_RS16540	COG0739	heme binding
O1G22_RS16565	COG2197	response regulator
O1G22_RS16615	COG0519	Catalyzes the synthesis of GMP from XMP
O1G22_RS16615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O1G22_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS16640	COG0515	serine threonine protein kinase
O1G22_RS16645	COG0515	serine threonine protein kinase
O1G22_RS16650	COG2815	serine threonine protein kinase
O1G22_RS16650	COG0515	serine threonine protein kinase
O1G22_RS16655	COG0515	serine threonine protein kinase
O1G22_RS16660	COG2815	serine threonine protein kinase
O1G22_RS16660	COG0515	serine threonine protein kinase
O1G22_RS16675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O1G22_RS16690	COG0516	GMP reductase activity
O1G22_RS16700	COG1595	DNA-templated transcription, initiation
O1G22_RS16715	COG0583	DNA-binding transcription factor activity
O1G22_RS16725	COG4221	oxidoreductase activity
O1G22_RS16735	COG0459	protein refolding
O1G22_RS16745	COG0726	polysaccharide deacetylase
O1G22_RS16750	COG0726	polysaccharide deacetylase
O1G22_RS16765	COG4941	Belongs to the sigma-70 factor family
O1G22_RS16785	COG1609	Transcriptional regulator
O1G22_RS16805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O1G22_RS16825	COG0802	atpase or kinase
O1G22_RS16835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O1G22_RS16850	COG0736	holo-[acyl-carrier-protein] synthase activity
O1G22_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS16860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O1G22_RS16865	COG1072	(Pantothenic acid kinase))
O1G22_RS16880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1G22_RS16885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O1G22_RS16890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O1G22_RS16900	COG0101	tRNA pseudouridine synthase activity
O1G22_RS16905	COG0203	ribosomal protein L17
O1G22_RS16910	COG0202	RNA polymerase activity
O1G22_RS16915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O1G22_RS16920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O1G22_RS16925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O1G22_RS16930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O1G22_RS16940	COG0563	adenylate kinase activity
O1G22_RS16950	COG0200	Binds to the 23S rRNA
O1G22_RS16955	COG1841	ribosomal large subunit assembly
O1G22_RS16960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O1G22_RS16965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O1G22_RS16970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O1G22_RS16975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O1G22_RS16980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O1G22_RS16985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O1G22_RS16990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O1G22_RS16995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O1G22_RS17000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O1G22_RS17005	COG0255	Belongs to the universal ribosomal protein uL29 family
O1G22_RS17010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O1G22_RS17015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O1G22_RS17020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O1G22_RS17025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O1G22_RS17030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O1G22_RS17035	COG0089	rRNA binding
O1G22_RS17040	COG0088	Forms part of the polypeptide exit tunnel
O1G22_RS17045	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O1G22_RS17050	COG0051	transcription antitermination factor activity, RNA binding
O1G22_RS17085	COG2814	Major facilitator Superfamily
O1G22_RS17140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O1G22_RS17145	COG0049	tRNA binding
O1G22_RS17150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O1G22_RS17155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1G22_RS17185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O1G22_RS17190	COG0085	RNA polymerase activity
O1G22_RS17200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O1G22_RS17210	COG0081	regulation of translation
O1G22_RS17215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O1G22_RS17220	COG0250	Participates in transcription elongation, termination and antitermination
O1G22_RS17235	COG0436	Aminotransferase
O1G22_RS17240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1G22_RS17260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O1G22_RS17280	COG2030	dehydratase
O1G22_RS17285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O1G22_RS17300	COG0402	S-adenosylhomocysteine deaminase activity
O1G22_RS17305	COG0702	epimerase
O1G22_RS17405	COG1666	GTP binding
O1G22_RS17410	COG2261	transglycosylase associated protein
O1G22_RS17420	COG3304	Inner membrane component domain
O1G22_RS17425	COG0501	Belongs to the peptidase M48B family
O1G22_RS17430	COG1007	ATP synthesis coupled electron transport
O1G22_RS17435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1G22_RS17445	COG0713	ATP synthesis coupled electron transport
O1G22_RS17450	COG0839	Belongs to the complex I subunit 6 family
O1G22_RS17455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O1G22_RS17465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O1G22_RS17495	COG0674	pyruvate-flavodoxin oxidoreductase activity
O1G22_RS17500	COG1013	pyruvate-flavodoxin oxidoreductase activity
O1G22_RS17505	COG1733	regulation of RNA biosynthetic process
O1G22_RS17510	COG0702	epimerase
O1G22_RS17550	COG0142	geranyltranstransferase activity
O1G22_RS17560	COG0561	phosphatase activity
O1G22_RS17565	COG0492	ferredoxin-NADP+ reductase activity
O1G22_RS17585	COG2188	Transcriptional regulator
O1G22_RS17600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1G22_RS17610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O1G22_RS17615	COG0514	ATP-dependent DNA helicase (RecQ)
O1G22_RS17620	COG1007	ATP synthesis coupled electron transport
O1G22_RS17630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O1G22_RS17635	COG0713	ATP synthesis coupled electron transport
O1G22_RS17640	COG0839	Belongs to the complex I subunit 6 family
O1G22_RS17645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O1G22_RS17655	COG1034	ATP synthesis coupled electron transport
O1G22_RS17660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
O1G22_RS17670	COG0649	NAD binding
O1G22_RS17675	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O1G22_RS17695	COG0242	peptide deformylase activity
O1G22_RS17715	COG2226	methyltransferase
O1G22_RS17725	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
O1G22_RS17740	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
O1G22_RS17745	COG1278	Cold shock
O1G22_RS17770	COG0583	DNA-binding transcription factor activity
O1G22_RS17785	COG1309	transcriptional regulator
O1G22_RS17800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
O1G22_RS17810	COG0163	prenyltransferase activity
O1G22_RS17820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O1G22_RS17900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1G22_RS17905	COG1333	cytochrome c biogenesis protein
O1G22_RS17910	COG0785	Cytochrome C biogenesis protein
O1G22_RS17915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1G22_RS17925	COG0406	alpha-ribazole phosphatase activity
O1G22_RS17930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O1G22_RS17940	COG0640	Transcriptional regulator
O1G22_RS17960	COG0655	NAD(P)H dehydrogenase (quinone) activity
O1G22_RS18000	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS18045	COG2268	Band 7 protein
O1G22_RS18065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O1G22_RS18065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O1G22_RS18070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1G22_RS18080	COG2205	protein histidine kinase activity
O1G22_RS18100	COG1733	regulation of RNA biosynthetic process
O1G22_RS18110	COG1742	UPF0060 membrane protein
O1G22_RS18125	COG1690	Belongs to the RtcB family
O1G22_RS18145	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
O1G22_RS18150	COG0018	arginyl-trna synthetase
O1G22_RS18195	COG3328	transposase activity
O1G22_RS18210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1G22_RS18225	COG0113	porphobilinogen synthase activity
O1G22_RS18240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O1G22_RS18240	COG1648	precorrin-2 dehydrogenase activity
O1G22_RS18245	COG0181	hydroxymethylbilane synthase activity
O1G22_RS18250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O1G22_RS18255	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O1G22_RS18305	COG0123	including yeast histone deacetylase and acetoin utilization protein
O1G22_RS18320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1G22_RS18340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1G22_RS18350	COG0842	Transport permease protein
O1G22_RS18350	COG1129	ABC transporter
O1G22_RS18365	COG4991	sh3 domain protein
O1G22_RS18370	COG0515	serine threonine protein kinase
O1G22_RS18370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS18375	COG0129	dihydroxy-acid dehydratase activity
O1G22_RS18380	COG1309	transcriptional regulator
O1G22_RS18385	COG1082	Xylose isomerase domain protein TIM barrel
O1G22_RS18390	COG0248	Ppx GppA phosphatase
O1G22_RS18410	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O1G22_RS18425	COG1595	DNA-templated transcription, initiation
O1G22_RS18435	COG0745	RESPONSE REGULATOR receiver
O1G22_RS18440	COG2205	protein histidine kinase activity
O1G22_RS18455	COG0477	Major facilitator Superfamily
O1G22_RS18490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O1G22_RS18510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O1G22_RS18515	COG0157	Belongs to the NadC ModD family
O1G22_RS18520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O1G22_RS18525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O1G22_RS18550	COG2197	response regulator
O1G22_RS18565	COG0649	NAD binding
O1G22_RS18590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O1G22_RS18590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O1G22_RS18605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O1G22_RS18620	COG0302	gtp cyclohydrolase
O1G22_RS18635	COG0037	tRNA processing
O1G22_RS18645	COG2027	D-alanyl-D-alanine carboxypeptidase
O1G22_RS18650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O1G22_RS18665	COG0393	Putative heavy-metal-binding
O1G22_RS18670	COG0789	Transcriptional regulator
O1G22_RS18675	COG0076	glutamate decarboxylase activity
O1G22_RS18695	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS18755	COG1280	lysine exporter protein (LysE YggA)
O1G22_RS18765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1G22_RS18765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1G22_RS18770	COG3903	Transcriptional regulator
O1G22_RS18770	COG3629	intracellular signal transduction
O1G22_RS18825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O1G22_RS18835	COG0477	Major facilitator Superfamily
O1G22_RS18855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O1G22_RS18865	COG2197	response regulator
O1G22_RS18870	COG4585	Histidine kinase
O1G22_RS18895	COG0484	heat shock protein binding
O1G22_RS18900	COG0443	Heat shock 70 kDa protein
O1G22_RS18905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O1G22_RS18930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O1G22_RS18935	COG1754	DNA topoisomerase type I activity
O1G22_RS18935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1G22_RS18955	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
O1G22_RS18965	COG1366	Belongs to the anti-sigma-factor antagonist family
O1G22_RS18970	COG1111	helicase
O1G22_RS18970	COG1205	dead DEAH box helicase
O1G22_RS19035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1G22_RS19050	COG2267	carboxylic ester hydrolase activity
O1G22_RS19080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1G22_RS19105	COG0003	Pfam Anion-transporting ATPase
O1G22_RS19115	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O1G22_RS19125	COG1408	metallophosphoesterase
O1G22_RS19155	COG1733	regulation of RNA biosynthetic process
O1G22_RS19175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1G22_RS19190	COG2205	protein histidine kinase activity
O1G22_RS19190	COG2972	Histidine kinase
O1G22_RS19210	COG0772	Belongs to the SEDS family
O1G22_RS19215	COG1968	undecaprenyl-diphosphatase activity
O1G22_RS19225	COG0640	Transcriptional regulator
O1G22_RS19230	COG0531	amino acid
O1G22_RS19275	COG0701	Predicted permease
O1G22_RS19300	COG1595	DNA-templated transcription, initiation
O1G22_RS19320	COG0745	RESPONSE REGULATOR receiver
O1G22_RS19345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O1G22_RS19350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O1G22_RS19360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS19360	COG0515	serine threonine protein kinase
O1G22_RS19370	COG0693	protein deglycase activity
O1G22_RS19375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1G22_RS19380	COG1802	Transcriptional regulator
O1G22_RS19390	COG0737	Belongs to the 5'-nucleotidase family
O1G22_RS19395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O1G22_RS19410	COG1131	(ABC) transporter
O1G22_RS19415	COG3559	Exporter of polyketide antibiotics
O1G22_RS19435	COG2197	response regulator
O1G22_RS19440	COG4585	Histidine kinase
O1G22_RS19445	COG2197	response regulator
O1G22_RS19450	COG4585	Histidine kinase
O1G22_RS19470	COG3844	kynureninase activity
O1G22_RS19475	COG3483	tryptophan 2,3-dioxygenase activity
O1G22_RS19485	COG0477	Major facilitator Superfamily
O1G22_RS19495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O1G22_RS19510	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O1G22_RS19555	COG1132	(ABC) transporter
O1G22_RS19565	COG2197	response regulator
O1G22_RS19600	COG2814	Major facilitator Superfamily
O1G22_RS19630	COG0542	response to heat
O1G22_RS19665	COG4213	ABC transporter substrate-binding protein
O1G22_RS19670	COG0789	Transcriptional regulator
O1G22_RS19675	COG0484	heat shock protein binding
O1G22_RS19680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O1G22_RS19685	COG0443	Heat shock 70 kDa protein
O1G22_RS19690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O1G22_RS19695	COG0247	lactate metabolic process
O1G22_RS19695	COG2181	nitrate reductase activity
O1G22_RS19725	COG0489	protein tyrosine kinase activity
O1G22_RS19735	COG0726	polysaccharide deacetylase
O1G22_RS19745	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS19760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O1G22_RS19770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1G22_RS19780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O1G22_RS19785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O1G22_RS19890	COG2188	Transcriptional regulator
O1G22_RS19895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O1G22_RS19905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
O1G22_RS19910	COG0717	Belongs to the dCTP deaminase family
O1G22_RS19920	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
O1G22_RS19960	COG1278	Cold shock
O1G22_RS20025	COG3693	PFAM glycoside hydrolase, family 10
O1G22_RS20040	COG1595	DNA-templated transcription, initiation
O1G22_RS20070	COG0202	RNA polymerase activity
O1G22_RS20080	COG1278	Cold shock
O1G22_RS20160	COG4213	ABC transporter substrate-binding protein
O1G22_RS20220	COG0583	DNA-binding transcription factor activity
O1G22_RS20240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1G22_RS20250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1G22_RS20260	COG0477	Major facilitator Superfamily
O1G22_RS20265	COG0583	DNA-binding transcription factor activity
O1G22_RS20370	COG0366	Alpha amylase catalytic
O1G22_RS20390	COG1957	nucleoside hydrolase
O1G22_RS20395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1G22_RS20410	COG1396	sequence-specific DNA binding
O1G22_RS20435	COG4249	Peptidase C14 caspase catalytic subunit p20
O1G22_RS20435	COG2319	Wd-40 repeat
O1G22_RS20475	COG1289	transmembrane transporter activity
O1G22_RS20485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1G22_RS20490	COG3866	Pectate lyase
O1G22_RS20500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O1G22_RS20515	COG1741	Belongs to the pirin family
O1G22_RS20525	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS20530	COG1362	aminopeptidase activity
O1G22_RS20550	COG0662	Cupin 2, conserved barrel domain protein
O1G22_RS20580	COG2814	Major facilitator Superfamily
O1G22_RS20620	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1G22_RS20625	COG0022	dehydrogenase e1 component
O1G22_RS20640	COG0515	serine threonine protein kinase
O1G22_RS20645	COG0515	serine threonine protein kinase
O1G22_RS20660	COG0604	alcohol dehydrogenase
O1G22_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS20660	COG3321	synthase
O1G22_RS20695	COG1522	sequence-specific DNA binding
O1G22_RS20700	COG1309	transcriptional regulator
O1G22_RS20705	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1G22_RS20730	COG3396	Phenylacetate-CoA oxygenase
O1G22_RS20735	COG3460	Phenylacetate-CoA oxygenase
O1G22_RS20740	COG3396	Phenylacetate-CoA oxygenase
O1G22_RS20745	COG2151	metal-sulfur cluster biosynthetic enzyme
O1G22_RS20750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O1G22_RS20760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1G22_RS20780	COG1716	ATPase activity
O1G22_RS20785	COG1716	ATPase activity
O1G22_RS20800	COG0768	penicillin binding
O1G22_RS20805	COG0515	serine threonine protein kinase
O1G22_RS20815	COG3764	Sortase (surface protein transpeptidase)
O1G22_RS20820	COG3764	Sortase (surface protein transpeptidase)
O1G22_RS20835	COG3764	Sortase (surface protein transpeptidase)
O1G22_RS20850	COG0705	Rhomboid family
O1G22_RS20870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O1G22_RS20885	COG4221	oxidoreductase activity
O1G22_RS20890	COG2226	methyltransferase
O1G22_RS20910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1G22_RS20915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1G22_RS20925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1G22_RS20930	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS20935	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
O1G22_RS20980	COG0626	cystathionine gamma-synthase activity
O1G22_RS21010	COG0515	serine threonine protein kinase
O1G22_RS21045	COG2319	Wd-40 repeat
O1G22_RS21045	COG4249	Peptidase C14 caspase catalytic subunit p20
O1G22_RS21060	COG0582	viral genome integration into host DNA
O1G22_RS21075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O1G22_RS21080	COG0187	DNA topoisomerase II activity
O1G22_RS21085	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
O1G22_RS21090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O1G22_RS21095	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O1G22_RS21100	COG0592	DNA-directed DNA polymerase activity
O1G22_RS21105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1G22_RS21110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O1G22_RS21115	COG0594	ribonuclease P activity
O1G22_RS21120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O1G22_RS21125	COG0706	membrane insertase activity
O1G22_RS21135	COG0357	Ribosomal RNA small subunit methyltransferase G
O1G22_RS21140	COG1192	Involved in chromosome partitioning
O1G22_RS21155	COG3118	belongs to the thioredoxin family
O1G22_RS21160	COG0492	ferredoxin-NADP+ reductase activity
O1G22_RS21170	COG1595	DNA-templated transcription, initiation
O1G22_RS21175	COG2815	serine threonine protein kinase
O1G22_RS21175	COG0515	serine threonine protein kinase
O1G22_RS21190	COG0617	tRNA 3'-terminal CCA addition
O1G22_RS21210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O1G22_RS21235	COG0360	Binds together with S18 to 16S ribosomal RNA
O1G22_RS21240	COG0629	single-stranded DNA binding
O1G22_RS21245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O1G22_RS21250	COG0359	binds to the 23S rRNA
O1G22_RS21260	COG0305	Participates in initiation and elongation during chromosome replication
O1G22_RS21285	COG2814	Major facilitator Superfamily
O1G22_RS21320	COG0626	cystathionine gamma-synthase activity
O1G22_RS21325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1G22_RS21330	COG1950	PFAM Membrane protein of
O1G22_RS21335	COG0662	Cupin 2, conserved barrel domain protein
O1G22_RS21360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O1G22_RS21390	COG1609	Transcriptional regulator
O1G22_RS21395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O1G22_RS21405	COG1271	oxidase subunit
O1G22_RS21410	COG1294	oxidase, subunit
O1G22_RS21415	COG4988	ABC transporter
O1G22_RS21420	COG0561	phosphatase activity
O1G22_RS21435	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
O1G22_RS21440	COG0789	Transcriptional regulator
O1G22_RS21485	COG0561	phosphatase activity
O1G22_RS21490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O1G22_RS21495	COG0077	Prephenate dehydratase
O1G22_RS21500	COG2837	iron assimilation
O1G22_RS21535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1G22_RS21540	COG0006	proline dipeptidase activity
O1G22_RS21560	COG0653	protein targeting
O1G22_RS21575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1G22_RS21610	COG1595	DNA-templated transcription, initiation
O1G22_RS21615	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS21620	COG2814	Major facilitator Superfamily
O1G22_RS21625	COG1309	transcriptional regulator
O1G22_RS21630	COG0784	Response regulator, receiver
O1G22_RS21680	COG1846	Transcriptional regulator
O1G22_RS21700	COG0745	RESPONSE REGULATOR receiver
O1G22_RS21705	COG2205	protein histidine kinase activity
O1G22_RS21715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O1G22_RS21720	COG0477	Major facilitator Superfamily
O1G22_RS21730	COG3467	pyridoxamine 5'-phosphate
O1G22_RS21735	COG2353	YceI-like domain
O1G22_RS21760	COG1191	sigma factor activity
O1G22_RS21765	COG1191	sigma factor activity
O1G22_RS21800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O1G22_RS21850	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS21855	COG1276	copper resistance
O1G22_RS21855	COG2372	response to copper ion
O1G22_RS21890	COG0151	Belongs to the GarS family
O1G22_RS21905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O1G22_RS21935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1G22_RS21940	COG0047	phosphoribosylformylglycinamidine synthase activity
O1G22_RS21945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1G22_RS21955	COG1309	transcriptional regulator
O1G22_RS21975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O1G22_RS22010	COG1643	Atp-dependent helicase
O1G22_RS22065	COG0513	Belongs to the DEAD box helicase family
O1G22_RS22200	COG0477	Major facilitator Superfamily
O1G22_RS22205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1G22_RS22215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1G22_RS22215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1G22_RS22245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O1G22_RS22250	COG0579	oxidoreductase
O1G22_RS22280	COG1252	NADH dehydrogenase
O1G22_RS22455	COG0791	NLP P60 protein
O1G22_RS22460	COG0671	phosphoesterase, PA-phosphatase related
O1G22_RS22465	COG0277	FAD linked oxidase domain protein
O1G22_RS22485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1G22_RS22490	COG0306	phosphate transporter
O1G22_RS22500	COG1937	Protein conserved in bacteria
O1G22_RS22515	COG0494	nUDIX hydrolase
O1G22_RS22515	COG0406	alpha-ribazole phosphatase activity
O1G22_RS22525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O1G22_RS22540	COG3842	ATPase activity
O1G22_RS22545	COG1725	Transcriptional regulator
O1G22_RS22560	COG1131	(ABC) transporter
O1G22_RS22575	COG0456	acetyltransferase
O1G22_RS22580	COG1132	(ABC) transporter
O1G22_RS22590	COG2205	protein histidine kinase activity
O1G22_RS22590	COG2972	Histidine kinase
O1G22_RS22605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1G22_RS22610	COG1609	Transcriptional regulator
O1G22_RS22615	COG0745	RESPONSE REGULATOR receiver
O1G22_RS22650	COG2897	thiosulfate sulfurtransferase activity
O1G22_RS22700	COG3485	protocatechuate 3,4-dioxygenase
O1G22_RS22715	COG1490	D-aminoacyl-tRNA deacylase activity
O1G22_RS22725	COG4552	Acetyltransferase involved in intracellular survival and related
O1G22_RS22735	COG2188	Transcriptional regulator
O1G22_RS22745	COG0546	phosphoglycolate phosphatase activity
O1G22_RS22755	COG1309	transcriptional regulator
O1G22_RS22765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O1G22_RS22770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O1G22_RS22775	COG1280	lysine exporter protein (LysE YggA)
O1G22_RS22780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1G22_RS22835	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS22855	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS22870	COG0588	phosphoglycerate mutase activity
O1G22_RS22900	COG5002	protein histidine kinase activity
O1G22_RS22930	COG1329	Transcriptional regulator
O1G22_RS22935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O1G22_RS22940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O1G22_RS22950	COG0215	cysteine-tRNA ligase activity
O1G22_RS22955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1G22_RS22975	COG3842	ATPase activity
O1G22_RS22995	COG0747	negative chemotaxis
O1G22_RS23000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1G22_RS23070	COG0308	aminopeptidase N
O1G22_RS23095	COG3300	MHYT domain
O1G22_RS23095	COG5001	Diguanylate cyclase
O1G22_RS23105	COG1105	Belongs to the carbohydrate kinase PfkB family
O1G22_RS23140	COG0463	Glycosyl transferase, family 2
O1G22_RS23155	COG1278	Cold shock
O1G22_RS23160	COG0459	protein refolding
O1G22_RS23195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O1G22_RS23200	COG1737	Transcriptional regulator
O1G22_RS23225	COG3142	Participates in the control of copper homeostasis
O1G22_RS23235	COG3973	AAA domain
O1G22_RS23245	COG1061	Type III restriction enzyme res subunit
O1G22_RS23270	COG1278	Cold shock
O1G22_RS23285	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
O1G22_RS23290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O1G22_RS23300	COG2814	Major facilitator Superfamily
O1G22_RS23355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O1G22_RS23365	COG2252	PERMEase
O1G22_RS23400	COG0667	Aldo Keto reductase
O1G22_RS23430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O1G22_RS23440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O1G22_RS23445	COG0277	FAD linked oxidase domain protein
O1G22_RS23460	COG1132	(ABC) transporter
O1G22_RS23465	COG5006	permease, DMT superfamily
O1G22_RS23480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1G22_RS23485	COG4770	biotin carboxylase activity
O1G22_RS23495	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS23505	COG1309	transcriptional regulator
O1G22_RS23525	COG0259	pyridoxamine-phosphate oxidase activity
O1G22_RS23540	COG4821	SIS domain
O1G22_RS23640	COG2226	methyltransferase
O1G22_RS23650	COG4585	Histidine kinase
O1G22_RS23655	COG2197	response regulator
O1G22_RS23670	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS23680	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS23685	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS23705	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS23710	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS23715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O1G22_RS23725	COG2814	Major facilitator Superfamily
O1G22_RS23730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O1G22_RS23745	COG1024	Enoyl-CoA hydratase
O1G22_RS23755	COG2072	flavoprotein involved in K transport
O1G22_RS23775	COG0259	pyridoxamine-phosphate oxidase activity
O1G22_RS23785	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS23795	COG1280	lysine exporter protein (LysE YggA)
O1G22_RS23800	COG1522	sequence-specific DNA binding
O1G22_RS23805	COG1309	transcriptional regulator
O1G22_RS23815	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS23815	COG0515	serine threonine protein kinase
O1G22_RS23820	COG1024	Enoyl-CoA hydratase
O1G22_RS23835	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS23865	COG3903	Transcriptional regulator
O1G22_RS23865	COG3629	intracellular signal transduction
O1G22_RS23895	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS23935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
O1G22_RS23995	COG0596	Alpha beta hydrolase
O1G22_RS24030	COG1686	Belongs to the peptidase S11 family
O1G22_RS24055	COG0386	Belongs to the glutathione peroxidase family
O1G22_RS24070	COG0330	HflC and HflK could
O1G22_RS24080	COG1366	Belongs to the anti-sigma-factor antagonist family
O1G22_RS24080	COG2172	sigma factor antagonist activity
O1G22_RS24080	COG2208	phosphoserine phosphatase activity
O1G22_RS24095	COG0366	Alpha amylase catalytic
O1G22_RS24100	COG0395	ABC-type sugar transport system, permease component
O1G22_RS24105	COG4209	transmembrane transport
O1G22_RS24115	COG1609	Transcriptional regulator
O1G22_RS24155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1G22_RS24195	COG3328	transposase activity
O1G22_RS24280	COG1609	Transcriptional regulator
O1G22_RS24335	COG0582	viral genome integration into host DNA
O1G22_RS24345	COG1414	Transcriptional regulator
O1G22_RS24365	COG1846	Transcriptional regulator
O1G22_RS24370	COG3384	dioxygenase
O1G22_RS24385	COG0789	Transcriptional regulator
O1G22_RS24400	COG0477	Major facilitator Superfamily
O1G22_RS24405	COG1349	DNA-binding transcription factor activity
O1G22_RS24415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1G22_RS24415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1G22_RS24415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1G22_RS24430	COG1376	ErfK ybiS ycfS ynhG family protein
O1G22_RS24435	COG3191	aminopeptidase activity
O1G22_RS24450	COG1970	mechanosensitive ion channel activity
O1G22_RS24460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O1G22_RS24470	COG0477	Major facilitator Superfamily
O1G22_RS24475	COG3263	regulation of cellular component size
O1G22_RS24485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O1G22_RS24490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1G22_RS24500	COG0315	cyclic pyranopterin monophosphate synthase activity
O1G22_RS24505	COG0315	cyclic pyranopterin monophosphate synthase activity
O1G22_RS24505	COG0521	Mo-molybdopterin cofactor biosynthetic process
O1G22_RS24510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1G22_RS24540	COG2072	flavoprotein involved in K transport
O1G22_RS24545	COG2267	carboxylic ester hydrolase activity
O1G22_RS24550	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS24560	COG0793	Belongs to the peptidase S41A family
O1G22_RS24560	COG4946	Tricorn protease homolog
O1G22_RS24570	COG2409	Drug exporters of the RND superfamily
O1G22_RS24575	COG0442	prolyl-tRNA aminoacylation
O1G22_RS24610	COG1764	response to oxidative stress
O1G22_RS24615	COG1846	Transcriptional regulator
O1G22_RS24620	COG1122	ATPase activity
O1G22_RS24630	COG0310	cobalt ion transport
O1G22_RS24670	COG0084	hydrolase, TatD family'
O1G22_RS24675	COG3583	domain protein
O1G22_RS24675	COG3584	3D domain protein
O1G22_RS24680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O1G22_RS24685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O1G22_RS24695	COG0488	(ABC) transporter
O1G22_RS24735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O1G22_RS24755	COG2197	response regulator
O1G22_RS24765	COG4106	trans-aconitate 2-methyltransferase activity
O1G22_RS24780	COG1309	transcriptional regulator
O1G22_RS24790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O1G22_RS24800	COG0193	aminoacyl-tRNA hydrolase activity
O1G22_RS24805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O1G22_RS24810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O1G22_RS24815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O1G22_RS24830	COG4585	Histidine kinase
O1G22_RS24870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1G22_RS24880	COG0477	Major facilitator Superfamily
O1G22_RS24885	COG1136	(ABC) transporter
O1G22_RS24890	COG0577	efflux transmembrane transporter activity
O1G22_RS24960	COG2124	cytochrome p450
O1G22_RS24970	COG1652	LysM domain
O1G22_RS24980	COG0148	phosphopyruvate hydratase activity
O1G22_RS25000	COG1252	NADH dehydrogenase
O1G22_RS25005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O1G22_RS25010	COG0577	efflux transmembrane transporter activity
O1G22_RS25015	COG1136	(ABC) transporter
O1G22_RS25050	COG0183	Belongs to the thiolase family
O1G22_RS25055	COG2755	lipolytic protein G-D-S-L family
O1G22_RS25070	COG4221	oxidoreductase activity
O1G22_RS25085	COG2986	histidine ammonia-lyase
O1G22_RS25125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O1G22_RS25130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1G22_RS25140	COG1228	amidohydrolase
O1G22_RS25155	COG1191	sigma factor activity
O1G22_RS25160	COG1366	Belongs to the anti-sigma-factor antagonist family
O1G22_RS25190	COG3104	oligopeptide transport
O1G22_RS25195	COG0745	RESPONSE REGULATOR receiver
O1G22_RS25200	COG2205	protein histidine kinase activity
O1G22_RS25215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O1G22_RS25225	COG1902	pentaerythritol trinitrate reductase activity
O1G22_RS25240	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O1G22_RS25250	COG2226	methyltransferase
O1G22_RS25260	COG1316	TRANSCRIPTIONal
O1G22_RS25270	COG1316	TRANSCRIPTIONal
O1G22_RS25280	COG1316	TRANSCRIPTIONal
O1G22_RS25285	COG1316	TRANSCRIPTIONal
O1G22_RS25315	COG0778	Nitroreductase
O1G22_RS25315	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
O1G22_RS25320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O1G22_RS25360	COG2835	tetraacyldisaccharide 4'-kinase activity
O1G22_RS25370	COG1482	cell wall glycoprotein biosynthetic process
O1G22_RS25380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
O1G22_RS25420	COG0714	Associated with various cellular activities
O1G22_RS25450	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O1G22_RS25465	COG0745	RESPONSE REGULATOR receiver
O1G22_RS25470	COG5000	phosphorelay sensor kinase activity
O1G22_RS25470	COG5002	protein histidine kinase activity
O1G22_RS25475	COG0823	Involved in the tonB-independent uptake of proteins
O1G22_RS25485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O1G22_RS25490	COG2197	response regulator
O1G22_RS25495	COG3214	Protein conserved in bacteria
O1G22_RS25505	COG0653	protein targeting
O1G22_RS25530	COG2902	Dehydrogenase
O1G22_RS25540	COG1215	transferase activity, transferring glycosyl groups
O1G22_RS25545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O1G22_RS25550	COG1134	teichoic acid transport
O1G22_RS25575	COG1215	transferase activity, transferring glycosyl groups
O1G22_RS25585	COG1846	Transcriptional regulator
O1G22_RS25590	COG1764	response to oxidative stress
O1G22_RS25600	COG0395	ABC-type sugar transport system, permease component
O1G22_RS25605	COG1175	transmembrane transport
O1G22_RS25620	COG0515	serine threonine protein kinase
O1G22_RS25625	COG0515	serine threonine protein kinase
O1G22_RS25630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
O1G22_RS25645	COG2884	Cell division ATP-binding protein ftsE
O1G22_RS25650	COG2177	Part of the ABC transporter FtsEX involved in
O1G22_RS25655	COG0793	Belongs to the peptidase S41A family
O1G22_RS25660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O1G22_RS25670	COG0395	ABC-type sugar transport system, permease component
O1G22_RS25675	COG4209	transmembrane transport
O1G22_RS25690	COG0583	DNA-binding transcription factor activity
O1G22_RS25705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1G22_RS25715	COG3290	protein histidine kinase activity
O1G22_RS25720	COG4565	transcriptional regulatory protein
O1G22_RS25725	COG2223	nitrite transmembrane transporter activity
O1G22_RS25760	COG0640	Transcriptional regulator
O1G22_RS25815	COG3973	AAA domain
O1G22_RS25825	COG0776	regulation of translation
O1G22_RS25830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1G22_RS25835	COG1678	Uncharacterized ACR, COG1678
O1G22_RS25845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
O1G22_RS26000	COG0531	amino acid
O1G22_RS26020	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS26045	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O1G22_RS26050	COG0277	FAD linked oxidase domain protein
O1G22_RS26090	COG1335	isochorismatase
O1G22_RS26100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O1G22_RS26110	COG1113	amino acid transport
O1G22_RS26145	COG1234	tRNA 3'-trailer cleavage
O1G22_RS26150	COG1263	PTS System
O1G22_RS26155	COG1263	PTS System
O1G22_RS26160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1G22_RS26165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O1G22_RS26195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1G22_RS26225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O1G22_RS26235	COG2733	membrane
O1G22_RS26240	COG0222	ribosome binding
O1G22_RS26330	COG1074	ATP-dependent DNA helicase activity
O1G22_RS26365	COG0270	DNA (cytosine-5-)-methyltransferase activity
O1G22_RS26385	COG0701	Predicted permease
O1G22_RS26400	COG3764	Sortase (surface protein transpeptidase)
O1G22_RS26435	COG4702	Belongs to the UPF0303 family
O1G22_RS26440	COG0673	inositol 2-dehydrogenase activity
O1G22_RS26445	COG1940	carbohydrate kinase activity
O1G22_RS26465	COG2188	Transcriptional regulator
O1G22_RS26470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1G22_RS26475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1G22_RS26555	COG1126	abc transporter atp-binding protein
O1G22_RS26560	COG0765	amino acid transport
O1G22_RS26565	COG0765	amino acid transport
O1G22_RS26570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1G22_RS26580	COG2378	regulation of single-species biofilm formation
O1G22_RS26590	COG0154	amidase activity
O1G22_RS26610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS26665	COG0406	alpha-ribazole phosphatase activity
O1G22_RS26690	COG0745	RESPONSE REGULATOR receiver
O1G22_RS26700	COG3979	chitinase
O1G22_RS26710	COG0395	ABC-type sugar transport system, permease component
O1G22_RS26735	COG1595	DNA-templated transcription, initiation
O1G22_RS26750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O1G22_RS26755	COG4977	sequence-specific DNA binding
O1G22_RS26760	COG0589	response to stress
O1G22_RS26770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O1G22_RS26805	COG3486	L-lysine 6-monooxygenase (NADPH) activity
O1G22_RS26825	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS26840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1G22_RS26845	COG1309	transcriptional regulator
O1G22_RS26855	COG1946	Acyl-CoA thioesterase
O1G22_RS26880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1G22_RS26890	COG0028	Belongs to the TPP enzyme family
O1G22_RS26900	COG1609	Transcriptional regulator
O1G22_RS26915	COG0395	ABC-type sugar transport system, permease component
O1G22_RS26935	COG2160	L-arabinose isomerase activity
O1G22_RS26940	COG0235	Class ii aldolase
O1G22_RS26945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O1G22_RS27000	COG1472	Belongs to the glycosyl hydrolase 3 family
O1G22_RS27005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O1G22_RS27030	COG1609	Transcriptional regulator
O1G22_RS27035	COG0673	inositol 2-dehydrogenase activity
O1G22_RS27085	COG1869	D-ribose catabolic process
O1G22_RS27090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS27100	COG1129	ABC transporter
O1G22_RS27140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O1G22_RS27165	COG1063	alcohol dehydrogenase
O1G22_RS27180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS27190	COG3718	enzyme involved in inositol metabolism
O1G22_RS27195	COG3962	Belongs to the TPP enzyme family
O1G22_RS27210	COG1131	(ABC) transporter
O1G22_RS27245	COG0492	ferredoxin-NADP+ reductase activity
O1G22_RS27270	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS27290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1G22_RS27295	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS27340	COG2304	oxidoreductase activity
O1G22_RS27350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1G22_RS27355	COG4566	intracellular signal transduction
O1G22_RS27390	COG0477	Major facilitator Superfamily
O1G22_RS27405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1G22_RS27445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1G22_RS27460	COG4770	biotin carboxylase activity
O1G22_RS27510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O1G22_RS27515	COG0629	single-stranded DNA binding
O1G22_RS27565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O1G22_RS27595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1G22_RS27610	COG1486	melibiose metabolic process
O1G22_RS27615	COG0395	ABC-type sugar transport system, permease component
O1G22_RS27620	COG1175	transmembrane transport
O1G22_RS27640	COG0668	transmembrane transport
O1G22_RS27650	COG1122	ATPase activity
O1G22_RS27690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1G22_RS27695	COG1846	Transcriptional regulator
O1G22_RS27705	COG0697	spore germination
O1G22_RS27720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1G22_RS27720	COG0512	Glutamine amidotransferase of anthranilate synthase
O1G22_RS27795	COG2755	lipolytic protein G-D-S-L family
O1G22_RS27810	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O1G22_RS27825	COG1113	amino acid transport
O1G22_RS27840	COG1116	anion transmembrane transporter activity
O1G22_RS27845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1G22_RS27850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1G22_RS27870	COG1113	amino acid transport
O1G22_RS27885	COG4552	Acetyltransferase involved in intracellular survival and related
O1G22_RS27925	COG0544	peptidyl-prolyl cis-trans isomerase activity
O1G22_RS27930	COG0740	serine-type endopeptidase activity
O1G22_RS27935	COG0740	serine-type endopeptidase activity
O1G22_RS27940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O1G22_RS27950	COG0525	valine-tRNA ligase activity
O1G22_RS27955	COG0285	dihydrofolate synthase activity
O1G22_RS27965	COG0105	UTP biosynthetic process
O1G22_RS27970	COG1077	Cell shape determining protein MreB Mrl
O1G22_RS27985	COG0768	penicillin binding
O1G22_RS27990	COG0772	Belongs to the SEDS family
O1G22_RS28005	COG0596	Alpha beta hydrolase
O1G22_RS28075	COG1530	ribonuclease E activity
O1G22_RS28080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O1G22_RS28085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O1G22_RS28090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O1G22_RS28095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O1G22_RS28105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O1G22_RS28120	COG0501	Belongs to the peptidase M48B family
O1G22_RS28135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O1G22_RS28145	COG0799	negative regulation of ribosome biogenesis
O1G22_RS28150	COG0406	alpha-ribazole phosphatase activity
O1G22_RS28175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
O1G22_RS28185	COG0495	leucyl-tRNA aminoacylation
O1G22_RS28195	COG1307	EDD domain protein, DegV family
O1G22_RS28200	COG1555	photosystem II stabilization
O1G22_RS28210	COG2353	YceI-like domain
O1G22_RS28225	COG0268	Binds directly to 16S ribosomal RNA
O1G22_RS28230	COG0481	GTPase activity
O1G22_RS28265	COG1420	regulation of RNA biosynthetic process
O1G22_RS28270	COG0484	heat shock protein binding
O1G22_RS28295	COG4946	Tricorn protease homolog
O1G22_RS28295	COG0793	Belongs to the peptidase S41A family
O1G22_RS28300	COG0537	adenosine 5'-monophosphoramidase activity
O1G22_RS28305	COG1234	tRNA 3'-trailer cleavage
O1G22_RS28310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1G22_RS28325	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS28340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O1G22_RS28350	COG2315	Protein conserved in bacteria
O1G22_RS28360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O1G22_RS28390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O1G22_RS28425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1G22_RS28435	COG2197	response regulator
O1G22_RS28440	COG4585	Histidine kinase
O1G22_RS28460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1G22_RS28470	COG1381	Involved in DNA repair and RecF pathway recombination
O1G22_RS28475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1G22_RS28490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1G22_RS28495	COG1121	(ABC) transporter
O1G22_RS28500	COG0803	Belongs to the bacterial solute-binding protein 9 family
O1G22_RS28500	COG3443	Belongs to the bacterial solute-binding protein 9 family
O1G22_RS28505	COG0423	glycine-tRNA ligase activity
O1G22_RS28510	COG0667	Aldo Keto reductase
O1G22_RS28530	COG0477	Major facilitator Superfamily
O1G22_RS28545	COG0477	Major facilitator Superfamily
O1G22_RS28570	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
O1G22_RS28575	COG1846	Transcriptional regulator
O1G22_RS28575	COG1940	carbohydrate kinase activity
O1G22_RS28580	COG0574	Belongs to the PEP-utilizing enzyme family
O1G22_RS28580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O1G22_RS28585	COG0395	ABC-type sugar transport system, permease component
O1G22_RS28590	COG1175	transmembrane transport
O1G22_RS28595	COG2182	Extracellular solute-binding protein
O1G22_RS28615	COG1136	(ABC) transporter
O1G22_RS28625	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS28630	COG1309	transcriptional regulator
O1G22_RS28640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1G22_RS28640	COG2146	nitrite reductase [NAD(P)H] activity
O1G22_RS28645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1G22_RS28680	COG0243	molybdopterin cofactor binding
O1G22_RS28685	COG2949	membrane
O1G22_RS28695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O1G22_RS28705	COG0358	DNA primase activity
O1G22_RS28710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O1G22_RS28725	COG1070	Carbohydrate kinase
O1G22_RS28770	COG0583	DNA-binding transcription factor activity
O1G22_RS28780	COG1077	Cell shape determining protein MreB Mrl
O1G22_RS28790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O1G22_RS28790	COG0825	malonyl-CoA metabolic process
O1G22_RS28795	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS28805	COG0583	DNA-binding transcription factor activity
O1G22_RS28820	COG1414	Transcriptional regulator
O1G22_RS28825	COG3386	PFAM SMP-30 Gluconolaconase
O1G22_RS28850	COG0395	ABC-type sugar transport system, permease component
O1G22_RS28855	COG3507	Belongs to the glycosyl hydrolase 43 family
O1G22_RS28885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1G22_RS28895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O1G22_RS28955	COG4214	carbohydrate transport
O1G22_RS28980	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS28995	COG1764	response to oxidative stress
O1G22_RS29000	COG2130	NADP-dependent
O1G22_RS29055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1G22_RS29060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1G22_RS29065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1G22_RS29080	COG1741	Belongs to the pirin family
O1G22_RS29095	COG0789	Transcriptional regulator
O1G22_RS29110	COG1309	transcriptional regulator
O1G22_RS29115	COG0477	Major facilitator Superfamily
O1G22_RS29120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O1G22_RS29125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O1G22_RS29170	COG1358	cellular component organization or biogenesis
O1G22_RS29185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1G22_RS29265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1G22_RS29305	COG4122	O-methyltransferase activity
O1G22_RS29340	COG0183	Belongs to the thiolase family
O1G22_RS29345	COG2124	cytochrome p450
O1G22_RS29350	COG3619	membrane
O1G22_RS29365	COG3845	ABC transporter
O1G22_RS29440	COG1309	transcriptional regulator
O1G22_RS29445	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS29470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS29480	COG0860	N-Acetylmuramoyl-L-alanine amidase
O1G22_RS29480	COG2247	cell wall binding repeat
O1G22_RS29490	COG0477	Major facilitator Superfamily
O1G22_RS29495	COG0183	Belongs to the thiolase family
O1G22_RS29500	COG2197	response regulator
O1G22_RS29510	COG4585	Histidine kinase
O1G22_RS29520	COG1131	(ABC) transporter
O1G22_RS29525	COG2030	dehydratase
O1G22_RS29535	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS29550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O1G22_RS29565	COG0800	Aldolase
O1G22_RS29570	COG3022	response to hydroperoxide
O1G22_RS29585	COG1309	transcriptional regulator
O1G22_RS29660	COG2259	Doxx family
O1G22_RS29675	COG1686	Belongs to the peptidase S11 family
O1G22_RS29690	COG2814	Major facilitator Superfamily
O1G22_RS29695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O1G22_RS29770	COG1994	Peptidase M50
O1G22_RS29790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O1G22_RS29795	COG0477	Major facilitator Superfamily
O1G22_RS29810	COG2814	Major facilitator Superfamily
O1G22_RS29840	COG1959	2 iron, 2 sulfur cluster binding
O1G22_RS29850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O1G22_RS29850	COG1017	nitric oxide dioxygenase activity
O1G22_RS29855	COG0174	glutamine synthetase
O1G22_RS29865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O1G22_RS29865	COG2080	2 iron, 2 sulfur cluster binding
O1G22_RS29885	COG3511	phospholipase C
O1G22_RS29890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O1G22_RS29900	COG1609	Transcriptional regulator
O1G22_RS29910	COG1175	transmembrane transport
O1G22_RS29915	COG3833	ABC-type maltose transport systems, permease component
O1G22_RS29920	COG0366	Alpha amylase catalytic
O1G22_RS29975	COG2197	response regulator
O1G22_RS29990	COG0745	RESPONSE REGULATOR receiver
O1G22_RS30010	COG0596	Alpha beta hydrolase
O1G22_RS30045	COG0501	Belongs to the peptidase M48B family
O1G22_RS30080	COG2188	Transcriptional regulator
O1G22_RS30185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O1G22_RS30190	COG0174	glutamine synthetase
O1G22_RS30200	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS30205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O1G22_RS30220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O1G22_RS30225	COG0321	lipoyl(octanoyl) transferase activity
O1G22_RS30275	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O1G22_RS30285	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1G22_RS30290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1G22_RS30295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O1G22_RS30305	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS30325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
O1G22_RS30345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O1G22_RS30350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O1G22_RS30365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1G22_RS30370	COG2226	methyltransferase
O1G22_RS30390	COG4585	Histidine kinase
O1G22_RS30395	COG2197	response regulator
O1G22_RS30400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1G22_RS30410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O1G22_RS30430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS30440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1G22_RS30445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1G22_RS30455	COG1376	ErfK ybiS ycfS ynhG family protein
O1G22_RS30465	COG1845	cytochrome c oxidase, subunit III
O1G22_RS30470	COG2010	Cytochrome c
O1G22_RS30475	COG0723	plastoquinol--plastocyanin reductase activity
O1G22_RS30480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O1G22_RS30485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O1G22_RS30490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O1G22_RS30520	COG3883	PFAM NLP P60 protein
O1G22_RS30520	COG0791	NLP P60 protein
O1G22_RS30535	COG0534	Mate efflux family protein
O1G22_RS30545	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS30570	COG0003	Pfam Anion-transporting ATPase
O1G22_RS30580	COG1940	carbohydrate kinase activity
O1G22_RS30605	COG4585	Histidine kinase
O1G22_RS30615	COG0205	6-phosphofructokinase activity
O1G22_RS30625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
O1G22_RS30630	COG0243	molybdopterin cofactor binding
O1G22_RS30635	COG2193	ferroxidase activity
O1G22_RS30640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O1G22_RS30645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O1G22_RS30650	COG2815	serine threonine protein kinase
O1G22_RS30650	COG0515	serine threonine protein kinase
O1G22_RS30655	COG2022	thiamine diphosphate biosynthetic process
O1G22_RS30665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1G22_RS30665	COG2022	thiamine diphosphate biosynthetic process
O1G22_RS30680	COG0352	thiamine-phosphate diphosphorylase activity
O1G22_RS30700	COG1309	transcriptional regulator
O1G22_RS30710	COG1121	(ABC) transporter
O1G22_RS30740	COG0714	Associated with various cellular activities
O1G22_RS30750	COG0275	rRNA processing
O1G22_RS30765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O1G22_RS30775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O1G22_RS30780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O1G22_RS30790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O1G22_RS30795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O1G22_RS30800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O1G22_RS30805	COG1496	oxidoreductase activity
O1G22_RS30815	COG1799	cell septum assembly
O1G22_RS30825	COG3599	regulation of cell shape
O1G22_RS30830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O1G22_RS30840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O1G22_RS30890	COG0587	DNA-directed DNA polymerase activity
O1G22_RS30900	COG1432	Conserved Protein
O1G22_RS30925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O1G22_RS30945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O1G22_RS30950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O1G22_RS30955	COG0131	Imidazoleglycerol-phosphate dehydratase
O1G22_RS30965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O1G22_RS30970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O1G22_RS30975	COG0251	oxidation-reduction process
O1G22_RS30980	COG0107	imidazoleglycerol-phosphate synthase activity
O1G22_RS31000	COG0346	lactoylglutathione lyase activity
O1G22_RS31010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O1G22_RS31040	COG0134	indole-3-glycerol-phosphate synthase activity
O1G22_RS31045	COG0133	tryptophan synthase activity
O1G22_RS31050	COG0159	tryptophan synthase activity
O1G22_RS31060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O1G22_RS31075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS31095	COG1397	ADP-ribosylglycohydrolase
O1G22_RS31105	COG0070	glutamate synthase
O1G22_RS31105	COG0069	glutamate synthase activity
O1G22_RS31105	COG0067	glutamate synthase
O1G22_RS31115	COG2304	oxidoreductase activity
O1G22_RS31125	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS31135	COG1309	transcriptional regulator
O1G22_RS31160	COG1024	Enoyl-CoA hydratase
O1G22_RS31165	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS31170	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS31190	COG0287	Prephenate dehydrogenase
O1G22_RS31190	COG1605	Chorismate mutase
O1G22_RS31200	COG0702	epimerase
O1G22_RS31220	COG0737	Belongs to the 5'-nucleotidase family
O1G22_RS31245	COG0411	ABC transporter
O1G22_RS31275	COG2050	protein possibly involved in aromatic compounds catabolism
O1G22_RS31315	COG1643	Atp-dependent helicase
O1G22_RS31320	COG2226	methyltransferase
O1G22_RS31325	COG0539	negative regulation of cytoplasmic translation
O1G22_RS31335	COG0237	dephospho-CoA kinase activity
O1G22_RS31355	COG2226	methyltransferase
O1G22_RS31370	COG1802	Transcriptional regulator
O1G22_RS31375	COG1953	Uracil, thiamine, allantoin
O1G22_RS31460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1G22_RS31465	COG0515	serine threonine protein kinase
O1G22_RS31465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS31495	COG1132	(ABC) transporter
O1G22_RS31525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1G22_RS31530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS31550	COG2910	NAD(P)H-binding
O1G22_RS31565	COG0598	Magnesium transport protein CorA
O1G22_RS31570	COG2226	methyltransferase
O1G22_RS31580	COG2313	pseudouridylate synthase activity
O1G22_RS31590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O1G22_RS31595	COG0584	glycerophosphoryl diester phosphodiesterase
O1G22_RS31605	COG0556	nucleotide-excision repair
O1G22_RS31625	COG0387	Pfam Sodium calcium exchanger
O1G22_RS31630	COG0477	Major facilitator Superfamily
O1G22_RS31635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O1G22_RS31645	COG0765	amino acid transport
O1G22_RS31650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1G22_RS31655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1G22_RS31665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O1G22_RS31675	COG1609	Transcriptional regulator
O1G22_RS31680	COG0723	plastoquinol--plastocyanin reductase activity
O1G22_RS31695	COG0322	excinuclease ABC activity
O1G22_RS31700	COG1660	Displays ATPase and GTPase activities
O1G22_RS31705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O1G22_RS31710	COG1481	regulation of sporulation
O1G22_RS31720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1G22_RS31725	COG0126	phosphoglycerate kinase activity
O1G22_RS31730	COG0149	triose-phosphate isomerase activity
O1G22_RS31735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O1G22_RS31745	COG0166	Belongs to the GPI family
O1G22_RS31755	COG1136	(ABC) transporter
O1G22_RS31760	COG1695	Transcriptional regulator
O1G22_RS31765	COG1653	transport
O1G22_RS31770	COG0366	Alpha amylase catalytic
O1G22_RS31775	COG1653	transport
O1G22_RS31780	COG1175	transmembrane transport
O1G22_RS31785	COG0395	ABC-type sugar transport system, permease component
O1G22_RS31795	COG0363	glucosamine-6-phosphate deaminase activity
O1G22_RS31810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O1G22_RS31820	COG0109	protoheme IX farnesyltransferase activity
O1G22_RS31840	COG1612	heme a metabolic process
O1G22_RS31850	COG1131	(ABC) transporter
O1G22_RS31855	COG2746	aminoglycoside 3-N-acetyltransferase activity
O1G22_RS31870	COG0719	Fe-S assembly protein
O1G22_RS31880	COG0396	ATPase activity
O1G22_RS31885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O1G22_RS31890	COG0822	iron-sulfur transferase activity
O1G22_RS31895	COG2151	metal-sulfur cluster biosynthetic enzyme
O1G22_RS31910	COG3226	Transcriptional regulator
O1G22_RS31915	COG2171	N-acyltransferase activity
O1G22_RS31925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1G22_RS31975	COG1309	transcriptional regulator
O1G22_RS31985	COG1063	alcohol dehydrogenase
O1G22_RS31990	COG0395	ABC-type sugar transport system, permease component
O1G22_RS32005	COG1349	DNA-binding transcription factor activity
O1G22_RS32010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O1G22_RS32015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1G22_RS32035	COG1234	tRNA 3'-trailer cleavage
O1G22_RS32040	COG1802	Transcriptional regulator
O1G22_RS32045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1G22_RS32055	COG1175	transmembrane transport
O1G22_RS32060	COG0395	ABC-type sugar transport system, permease component
O1G22_RS32085	COG2755	lipolytic protein G-D-S-L family
O1G22_RS32090	COG3866	Pectate lyase
O1G22_RS32095	COG4677	pectinesterase activity
O1G22_RS32100	COG4733	cellulase activity
O1G22_RS32125	COG1595	DNA-templated transcription, initiation
O1G22_RS32130	COG2252	PERMEase
O1G22_RS32140	COG1414	Transcriptional regulator
O1G22_RS32170	COG5285	phytanoyl-CoA dioxygenase
O1G22_RS32175	COG1917	Cupin 2, conserved barrel domain protein
O1G22_RS32180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1G22_RS32185	COG0456	acetyltransferase
O1G22_RS32190	COG2318	DinB family
O1G22_RS32195	COG1316	TRANSCRIPTIONal
O1G22_RS32215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O1G22_RS32220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1G22_RS32225	COG0765	amino acid transport
O1G22_RS32260	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
O1G22_RS32295	COG1797	cobyrinic acid a,c-diamide synthase activity
O1G22_RS32315	COG1492	cobalamin metabolic process
O1G22_RS32320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
O1G22_RS32340	COG0235	Class ii aldolase
O1G22_RS32365	COG0488	(ABC) transporter
O1G22_RS32375	COG1024	Enoyl-CoA hydratase
O1G22_RS32415	COG3387	PFAM Glycoside hydrolase 15-related
O1G22_RS32430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O1G22_RS32440	COG1063	alcohol dehydrogenase
O1G22_RS32450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O1G22_RS32460	COG1404	Belongs to the peptidase S8 family
O1G22_RS32470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1G22_RS32475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O1G22_RS32495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O1G22_RS32510	COG3328	transposase activity
O1G22_RS32525	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS32540	COG2186	Transcriptional regulator
O1G22_RS32560	COG0588	phosphoglycerate mutase activity
O1G22_RS32565	COG0560	Phosphoserine phosphatase
O1G22_RS32565	COG3830	Belongs to the UPF0237 family
O1G22_RS32575	COG0842	Transport permease protein
O1G22_RS32575	COG1131	(ABC) transporter
O1G22_RS32575	COG1716	ATPase activity
O1G22_RS32590	COG4585	Histidine kinase
O1G22_RS32595	COG2197	response regulator
O1G22_RS32610	COG1119	ATPase activity
O1G22_RS32630	COG1881	PFAM PEBP family protein
O1G22_RS32640	COG2094	Belongs to the DNA glycosylase MPG family
O1G22_RS32675	COG0647	UMP catabolic process
O1G22_RS32680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1G22_RS32685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1G22_RS32690	COG1120	ATPase activity
O1G22_RS32710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O1G22_RS32715	COG0497	DNA recombination
O1G22_RS32725	COG0297	glycogen (starch) synthase activity
O1G22_RS32740	COG3387	PFAM Glycoside hydrolase 15-related
O1G22_RS32745	COG0504	CTP synthase activity
O1G22_RS32750	COG0494	nUDIX hydrolase
O1G22_RS32760	COG0686	Belongs to the AlaDH PNT family
O1G22_RS32775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O1G22_RS32780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O1G22_RS32785	COG1187	pseudouridine synthase activity
O1G22_RS32790	COG1397	ADP-ribosylglycohydrolase
O1G22_RS32795	COG3541	Predicted nucleotidyltransferase
O1G22_RS32820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O1G22_RS32830	COG1160	GTP binding
O1G22_RS32845	COG1652	LysM domain
O1G22_RS32855	COG0671	phosphoesterase, PA-phosphatase related
O1G22_RS32865	COG0477	Major facilitator Superfamily
O1G22_RS32870	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS32875	COG1799	cell septum assembly
O1G22_RS32890	COG0765	amino acid transport
O1G22_RS32920	COG0587	DNA-directed DNA polymerase activity
O1G22_RS32955	COG4106	trans-aconitate 2-methyltransferase activity
O1G22_RS32970	COG1725	Transcriptional regulator
O1G22_RS32995	COG0726	polysaccharide deacetylase
O1G22_RS33015	COG2755	lipolytic protein G-D-S-L family
O1G22_RS33020	COG0515	serine threonine protein kinase
O1G22_RS33020	COG2815	serine threonine protein kinase
O1G22_RS33040	COG1595	DNA-templated transcription, initiation
O1G22_RS33055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O1G22_RS33085	COG2188	Transcriptional regulator
O1G22_RS33090	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O1G22_RS33100	COG1309	transcriptional regulator
O1G22_RS33105	COG0243	molybdopterin cofactor binding
O1G22_RS33110	COG2851	Citrate transporter
O1G22_RS33145	COG0640	Transcriptional regulator
O1G22_RS33155	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS33210	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS33235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
O1G22_RS33265	COG1063	alcohol dehydrogenase
O1G22_RS33270	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS33280	COG3265	gluconokinase activity
O1G22_RS33285	COG2186	Transcriptional regulator
O1G22_RS33290	COG3012	SEC-C Motif Domain Protein
O1G22_RS33300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1G22_RS33300	COG1796	DNA polymerase
O1G22_RS33305	COG0308	aminopeptidase N
O1G22_RS33350	COG0667	Aldo Keto reductase
O1G22_RS33355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS33380	COG0215	cysteine-tRNA ligase activity
O1G22_RS33390	COG2186	Transcriptional regulator
O1G22_RS33395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O1G22_RS33400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O1G22_RS33405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O1G22_RS33410	COG1414	Transcriptional regulator
O1G22_RS33415	COG0646	methionine synthase
O1G22_RS33415	COG1410	methionine synthase
O1G22_RS33420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1G22_RS33425	COG0747	negative chemotaxis
O1G22_RS33430	COG2197	response regulator
O1G22_RS33440	COG0517	IMP dehydrogenase activity
O1G22_RS33440	COG1994	Peptidase M50
O1G22_RS33460	COG1222	aaa ATPase
O1G22_RS33465	COG4122	O-methyltransferase activity
O1G22_RS33475	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O1G22_RS33480	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O1G22_RS33485	COG1609	Transcriptional regulator
O1G22_RS33495	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O1G22_RS33530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1G22_RS33535	COG0805	protein transport
O1G22_RS33590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1G22_RS33615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1G22_RS33620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O1G22_RS33630	COG0174	glutamine synthetase
O1G22_RS33635	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS33675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O1G22_RS33680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O1G22_RS33685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O1G22_RS33690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1G22_RS33695	COG5002	protein histidine kinase activity
O1G22_RS33700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O1G22_RS33705	COG0072	phenylalanine-tRNA ligase activity
O1G22_RS33705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1G22_RS33735	COG1649	PFAM Uncharacterised BCR, COG1649
O1G22_RS33745	COG0697	spore germination
O1G22_RS33795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O1G22_RS33800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O1G22_RS33805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O1G22_RS33810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1G22_RS33815	COG1438	arginine binding
O1G22_RS33830	COG0515	serine threonine protein kinase
O1G22_RS33830	COG2815	serine threonine protein kinase
O1G22_RS33835	COG1132	(ABC) transporter
O1G22_RS33865	COG0745	RESPONSE REGULATOR receiver
O1G22_RS33870	COG2205	protein histidine kinase activity
O1G22_RS33890	COG0137	argininosuccinate synthase activity
O1G22_RS33895	COG0165	Argininosuccinate lyase
O1G22_RS33910	COG0477	Major facilitator Superfamily
O1G22_RS33920	COG0584	glycerophosphoryl diester phosphodiesterase
O1G22_RS33950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1G22_RS33955	COG2011	ABC-type metal ion transport system permease component
O1G22_RS33960	COG1464	Belongs to the NlpA lipoprotein family
O1G22_RS33975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O1G22_RS33980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O1G22_RS33980	COG1648	precorrin-2 dehydrogenase activity
O1G22_RS34025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1G22_RS34090	COG1175	transmembrane transport
O1G22_RS34095	COG0395	ABC-type sugar transport system, permease component
O1G22_RS34120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O1G22_RS34135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1G22_RS34140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O1G22_RS34160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O1G22_RS34165	COG1560	Kdo2-lipid A biosynthetic process
O1G22_RS34170	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS34180	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O1G22_RS34185	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O1G22_RS34190	COG0217	transcriptional regulatory protein
O1G22_RS34195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O1G22_RS34200	COG0632	four-way junction helicase activity
O1G22_RS34205	COG2255	four-way junction helicase activity
O1G22_RS34215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1G22_RS34220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1G22_RS34225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1G22_RS34230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1G22_RS34235	COG1196	nuclear chromosome segregation
O1G22_RS34240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1G22_RS34250	COG0124	histidyl-tRNA synthetase
O1G22_RS34280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O1G22_RS34300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O1G22_RS34305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O1G22_RS34315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O1G22_RS34320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O1G22_RS34325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O1G22_RS34330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O1G22_RS34340	COG0006	proline dipeptidase activity
O1G22_RS34345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O1G22_RS34350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O1G22_RS34360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O1G22_RS34365	COG0540	Belongs to the ATCase OTCase family
O1G22_RS34370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O1G22_RS34380	COG0505	Belongs to the CarA family
O1G22_RS34385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O1G22_RS34390	COG0167	dihydroorotate dehydrogenase activity
O1G22_RS34395	COG0284	orotidine-5'-phosphate decarboxylase activity
O1G22_RS34405	COG0194	GDP metabolic process
O1G22_RS34420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O1G22_RS34435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O1G22_RS34445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O1G22_RS34450	COG2390	Transcriptional regulator
O1G22_RS34470	COG0531	amino acid
O1G22_RS34480	COG2188	Transcriptional regulator
O1G22_RS34500	COG3842	ATPase activity
O1G22_RS34515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1G22_RS34535	COG2233	PERMEase
O1G22_RS34545	COG0738	Major facilitator superfamily
O1G22_RS34550	COG1846	Transcriptional regulator
O1G22_RS34550	COG1940	carbohydrate kinase activity
O1G22_RS34560	COG1595	DNA-templated transcription, initiation
O1G22_RS34570	COG3201	nicotinamide mononucleotide transporter
O1G22_RS34575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1G22_RS34575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1G22_RS34580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O1G22_RS34585	COG0140	phosphoribosyl-ATP diphosphatase activity
O1G22_RS34590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O1G22_RS34645	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS34670	COG0463	Glycosyl transferase, family 2
O1G22_RS34675	COG3030	protein affecting phage T7 exclusion by the F plasmid
O1G22_RS34685	COG2270	Major facilitator Superfamily
O1G22_RS34695	COG2364	Membrane
O1G22_RS34725	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS34730	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS34735	COG2755	lipolytic protein G-D-S-L family
O1G22_RS34770	COG2018	Roadblock/LC7 domain
O1G22_RS34785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O1G22_RS34790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O1G22_RS34795	COG3706	GGDEF domain
O1G22_RS34820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1G22_RS34830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O1G22_RS34860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O1G22_RS34900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O1G22_RS34910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O1G22_RS34910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O1G22_RS34930	COG0725	ABC transporter, periplasmic molybdate-binding protein
O1G22_RS34940	COG2080	2 iron, 2 sulfur cluster binding
O1G22_RS34940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O1G22_RS34980	COG1175	transmembrane transport
O1G22_RS34985	COG0395	ABC-type sugar transport system, permease component
O1G22_RS35070	COG0697	spore germination
O1G22_RS35115	COG0747	negative chemotaxis
O1G22_RS35120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O1G22_RS35135	COG2318	DinB family
O1G22_RS35155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O1G22_RS35185	COG1968	undecaprenyl-diphosphatase activity
O1G22_RS35195	COG0183	Belongs to the thiolase family
O1G22_RS35210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O1G22_RS35245	COG1305	Transglutaminase-like
O1G22_RS35250	COG4302	ethanolamine ammonia-lyase activity
O1G22_RS35255	COG4303	Ethanolamine ammonia lyase large subunit
O1G22_RS35265	COG2197	response regulator
O1G22_RS35270	COG4585	Histidine kinase
O1G22_RS35280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O1G22_RS35305	COG0596	Alpha beta hydrolase
O1G22_RS35335	COG0110	maltose O-acetyltransferase activity
O1G22_RS35360	COG0640	Transcriptional regulator
O1G22_RS35370	COG0531	amino acid
O1G22_RS35375	COG1832	CoA-binding protein
O1G22_RS35390	COG1739	Uncharacterized protein family UPF0029
O1G22_RS35395	COG0420	3'-5' exonuclease activity
O1G22_RS35400	COG0419	ATPase involved in DNA repair
O1G22_RS35405	COG1522	sequence-specific DNA binding
O1G22_RS35455	COG0626	cystathionine gamma-synthase activity
O1G22_RS35480	COG1595	DNA-templated transcription, initiation
O1G22_RS35485	COG2188	Transcriptional regulator
O1G22_RS35490	COG1940	carbohydrate kinase activity
O1G22_RS35495	COG2197	response regulator
O1G22_RS35500	COG4585	Histidine kinase
O1G22_RS35520	COG3663	DNA glycosylase
O1G22_RS35525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O1G22_RS35565	COG0456	acetyltransferase
O1G22_RS35570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS35575	COG1136	(ABC) transporter
O1G22_RS35575	COG0577	efflux transmembrane transporter activity
O1G22_RS35580	COG1136	(ABC) transporter
O1G22_RS35580	COG0577	efflux transmembrane transporter activity
O1G22_RS35595	COG2226	methyltransferase
O1G22_RS35600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O1G22_RS35605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1G22_RS35610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O1G22_RS35615	COG0156	8-amino-7-oxononanoate synthase activity
O1G22_RS35645	COG0740	serine-type endopeptidase activity
O1G22_RS35655	COG0831	urea catabolic process
O1G22_RS35660	COG0832	Belongs to the urease beta subunit family
O1G22_RS35665	COG0804	urea catabolic process
O1G22_RS35670	COG0830	nickel cation binding
O1G22_RS35675	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
O1G22_RS35680	COG0829	nickel cation binding
O1G22_RS35705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1G22_RS35710	COG1834	amidinotransferase
O1G22_RS35715	COG1522	sequence-specific DNA binding
O1G22_RS35730	COG0205	6-phosphofructokinase activity
O1G22_RS35735	COG3442	glutamine amidotransferase
O1G22_RS35745	COG0242	peptide deformylase activity
O1G22_RS35755	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS35765	COG2124	cytochrome p450
O1G22_RS35770	COG3424	synthase
O1G22_RS35780	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS35790	COG1793	dna ligase
O1G22_RS35795	COG0492	ferredoxin-NADP+ reductase activity
O1G22_RS35810	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS35815	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS35860	COG0586	Pfam SNARE associated Golgi protein
O1G22_RS35905	COG3864	Putative metallopeptidase domain
O1G22_RS35990	COG3328	transposase activity
O1G22_RS36000	COG3293	Transposase
O1G22_RS36005	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS36025	COG1113	amino acid transport
O1G22_RS36030	COG1940	carbohydrate kinase activity
O1G22_RS36050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1G22_RS36100	COG2018	Roadblock/LC7 domain
O1G22_RS36110	COG1946	Acyl-CoA thioesterase
O1G22_RS36125	COG0254	rRNA binding
O1G22_RS36135	COG1132	(ABC) transporter
O1G22_RS36165	COG1132	(ABC) transporter
O1G22_RS36175	COG2072	flavoprotein involved in K transport
O1G22_RS36185	COG1116	anion transmembrane transporter activity
O1G22_RS36190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1G22_RS36195	COG0432	Pfam Uncharacterised protein family UPF0047
O1G22_RS36215	COG0302	gtp cyclohydrolase
O1G22_RS36250	COG3387	PFAM Glycoside hydrolase 15-related
O1G22_RS36260	COG3794	PFAM blue (type 1) copper domain protein
O1G22_RS36270	COG3794	PFAM blue (type 1) copper domain protein
O1G22_RS36280	COG3548	integral membrane protein
O1G22_RS36325	COG1222	aaa ATPase
O1G22_RS36420	COG2205	protein histidine kinase activity
O1G22_RS36425	COG0745	RESPONSE REGULATOR receiver
O1G22_RS36455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O1G22_RS36460	COG1618	nucleotide phosphatase activity, acting on free nucleotides
O1G22_RS36470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O1G22_RS36505	COG0714	Associated with various cellular activities
O1G22_RS36580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1G22_RS36595	COG2706	6-phosphogluconolactonase activity
O1G22_RS36605	COG2971	BadF BadG BcrA BcrD
O1G22_RS36610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O1G22_RS36630	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS36645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1G22_RS36665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O1G22_RS36670	COG1902	pentaerythritol trinitrate reductase activity
O1G22_RS36675	COG0640	Transcriptional regulator
O1G22_RS36740	COG0584	glycerophosphoryl diester phosphodiesterase
O1G22_RS36775	COG2086	electron transfer activity
O1G22_RS36780	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O1G22_RS36810	COG3345	alpha-galactosidase
O1G22_RS36825	COG1660	Displays ATPase and GTPase activities
O1G22_RS36840	COG0445	tRNA wobble uridine modification
O1G22_RS36855	COG4585	Histidine kinase
O1G22_RS36860	COG2197	response regulator
O1G22_RS36885	COG0738	Major facilitator superfamily
O1G22_RS36895	COG1349	DNA-binding transcription factor activity
O1G22_RS36900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O1G22_RS36905	COG0191	fructose-bisphosphate aldolase activity
O1G22_RS36910	COG2813	Specifically methylates the guanine in position
O1G22_RS36920	COG1940	carbohydrate kinase activity
O1G22_RS36970	COG1349	DNA-binding transcription factor activity
O1G22_RS36985	COG0464	growth
O1G22_RS37010	COG1215	transferase activity, transferring glycosyl groups
O1G22_RS37040	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS37055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O1G22_RS37080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O1G22_RS37095	COG4585	Histidine kinase
O1G22_RS37100	COG2197	response regulator
O1G22_RS37110	COG0395	ABC-type sugar transport system, permease component
O1G22_RS37115	COG1175	transmembrane transport
O1G22_RS37120	COG1653	transport
O1G22_RS37140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1G22_RS37145	COG1993	acr, cog1993
O1G22_RS37150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1G22_RS37155	COG1968	undecaprenyl-diphosphatase activity
O1G22_RS37160	COG2186	Transcriptional regulator
O1G22_RS37165	COG1113	amino acid transport
O1G22_RS37180	COG2066	Belongs to the glutaminase family
O1G22_RS37195	COG1686	Belongs to the peptidase S11 family
O1G22_RS37200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O1G22_RS37225	COG2226	methyltransferase
O1G22_RS37230	COG2188	Transcriptional regulator
O1G22_RS37235	COG3458	cephalosporin-C deacetylase activity
O1G22_RS37250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O1G22_RS37265	COG1846	Transcriptional regulator
O1G22_RS37280	COG0714	Associated with various cellular activities
O1G22_RS37290	COG2890	protein-(glutamine-N5) methyltransferase activity
O1G22_RS37310	COG1902	pentaerythritol trinitrate reductase activity
O1G22_RS37310	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1G22_RS37340	COG1461	Dihydroxyacetone kinase
O1G22_RS37345	COG2376	Dihydroxyacetone kinase
O1G22_RS37360	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS37370	COG2409	Drug exporters of the RND superfamily
O1G22_RS37405	COG0753	catalase activity
O1G22_RS37415	COG0477	Major facilitator Superfamily
O1G22_RS37445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1G22_RS37450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1G22_RS37460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1G22_RS37475	COG1414	Transcriptional regulator
O1G22_RS37490	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS37500	COG0515	serine threonine protein kinase
O1G22_RS37510	COG2070	2-Nitropropane dioxygenase
O1G22_RS37520	COG2366	antibiotic biosynthetic process
O1G22_RS37525	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS37530	COG0539	negative regulation of cytoplasmic translation
O1G22_RS37535	COG0640	Transcriptional regulator
O1G22_RS37545	COG0596	Alpha beta hydrolase
O1G22_RS37560	COG1024	Enoyl-CoA hydratase
O1G22_RS37600	COG0510	thiamine kinase activity
O1G22_RS37620	COG3511	phospholipase C
O1G22_RS37625	COG0673	inositol 2-dehydrogenase activity
O1G22_RS37635	COG2267	carboxylic ester hydrolase activity
O1G22_RS37640	COG0367	asparagine synthase
O1G22_RS37695	COG3250	beta-galactosidase activity
O1G22_RS37705	COG0431	NADPH-dependent FMN reductase
O1G22_RS37710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS37730	COG4941	Belongs to the sigma-70 factor family
O1G22_RS37735	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS37740	COG0667	Aldo Keto reductase
O1G22_RS37755	COG0346	lactoylglutathione lyase activity
O1G22_RS37760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1G22_RS37770	COG0583	DNA-binding transcription factor activity
O1G22_RS37775	COG0667	Aldo Keto reductase
O1G22_RS37795	COG1131	(ABC) transporter
O1G22_RS37795	COG1716	ATPase activity
O1G22_RS37795	COG0842	Transport permease protein
O1G22_RS37830	COG1396	sequence-specific DNA binding
O1G22_RS37835	COG0596	Alpha beta hydrolase
O1G22_RS37850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O1G22_RS37860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1G22_RS37870	COG0328	RNA-DNA hybrid ribonuclease activity
O1G22_RS37905	COG0667	Aldo Keto reductase
O1G22_RS37925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS37930	COG0515	serine threonine protein kinase
O1G22_RS37930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS37935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O1G22_RS37940	COG0142	geranyltranstransferase activity
O1G22_RS37970	COG1940	carbohydrate kinase activity
O1G22_RS37970	COG1846	Transcriptional regulator
O1G22_RS37975	COG3345	alpha-galactosidase
O1G22_RS37990	COG2197	response regulator
O1G22_RS38005	COG0492	ferredoxin-NADP+ reductase activity
O1G22_RS38020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1G22_RS38055	COG5002	protein histidine kinase activity
O1G22_RS38100	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O1G22_RS38105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O1G22_RS38110	COG3281	Trehalose synthase
O1G22_RS38120	COG0366	Alpha amylase catalytic
O1G22_RS38155	COG0842	Transport permease protein
O1G22_RS38165	COG0181	hydroxymethylbilane synthase activity
O1G22_RS38180	COG0477	Major facilitator Superfamily
O1G22_RS38190	COG1063	alcohol dehydrogenase
O1G22_RS38215	COG5006	permease, DMT superfamily
O1G22_RS38235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O1G22_RS38295	COG1609	Transcriptional regulator
O1G22_RS38305	COG0395	ABC-type sugar transport system, permease component
O1G22_RS38310	COG1175	transmembrane transport
O1G22_RS38320	COG1621	beta-fructofuranosidase activity
O1G22_RS38345	COG2910	NAD(P)H-binding
O1G22_RS38365	COG2130	NADP-dependent
O1G22_RS38395	COG0009	L-threonylcarbamoyladenylate synthase
O1G22_RS38500	COG1609	Transcriptional regulator
O1G22_RS38515	COG0442	prolyl-tRNA aminoacylation
O1G22_RS38520	COG1733	regulation of RNA biosynthetic process
O1G22_RS38530	COG0583	DNA-binding transcription factor activity
O1G22_RS38535	COG3291	Pkd domain containing protein
O1G22_RS38570	COG2814	Major facilitator Superfamily
O1G22_RS38575	COG0586	Pfam SNARE associated Golgi protein
O1G22_RS38595	COG0667	Aldo Keto reductase
O1G22_RS38695	COG1024	Enoyl-CoA hydratase
O1G22_RS38695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O1G22_RS38710	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
O1G22_RS38715	COG0298	carbon dioxide binding
O1G22_RS38730	COG0375	protein maturation
O1G22_RS38755	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
O1G22_RS38785	COG0583	DNA-binding transcription factor activity
O1G22_RS38825	COG0701	Predicted permease
O1G22_RS38875	COG1316	TRANSCRIPTIONal
O1G22_RS38890	COG1090	epimerase
O1G22_RS38895	COG1090	epimerase
O1G22_RS38920	COG2508	Transcriptional regulator
O1G22_RS38925	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS38970	COG0745	RESPONSE REGULATOR receiver
O1G22_RS38975	COG5002	protein histidine kinase activity
O1G22_RS38995	COG2755	lipolytic protein G-D-S-L family
O1G22_RS39075	COG0464	growth
O1G22_RS39085	COG0823	Involved in the tonB-independent uptake of proteins
O1G22_RS39155	COG4585	Histidine kinase
O1G22_RS39160	COG2197	response regulator
O1G22_RS39180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1G22_RS39205	COG0586	Pfam SNARE associated Golgi protein
O1G22_RS39210	COG0726	polysaccharide deacetylase
O1G22_RS39215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O1G22_RS39230	COG0492	ferredoxin-NADP+ reductase activity
O1G22_RS39235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1G22_RS39240	COG1937	Protein conserved in bacteria
O1G22_RS39255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1G22_RS39255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1G22_RS39260	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS39280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
O1G22_RS39295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O1G22_RS39305	COG1984	allophanate hydrolase subunit 2
O1G22_RS39325	COG0657	acetylesterase activity
O1G22_RS39330	COG2362	D-Aminopeptidase
O1G22_RS39355	COG1024	Enoyl-CoA hydratase
O1G22_RS39360	COG1131	(ABC) transporter
O1G22_RS39385	COG3979	chitinase
O1G22_RS39440	COG4413	Urea transporter
O1G22_RS39445	COG0831	urea catabolic process
O1G22_RS39465	COG1846	Transcriptional regulator
O1G22_RS39485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O1G22_RS39495	COG0702	epimerase
O1G22_RS39500	COG1733	regulation of RNA biosynthetic process
O1G22_RS39510	COG2226	methyltransferase
O1G22_RS39525	COG2080	2 iron, 2 sulfur cluster binding
O1G22_RS39530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
O1G22_RS39535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O1G22_RS39555	COG0346	lactoylglutathione lyase activity
O1G22_RS39560	COG2326	polyphosphate kinase activity
O1G22_RS39595	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS39600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS39605	COG1597	lipid kinase activity
O1G22_RS39615	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS39620	COG0028	Belongs to the TPP enzyme family
O1G22_RS39625	COG3285	dna ligase
O1G22_RS39625	COG1793	dna ligase
O1G22_RS39640	COG1006	Multisubunit Na H antiporter MnhC subunit
O1G22_RS39670	COG0247	lactate metabolic process
O1G22_RS39670	COG0277	FAD linked oxidase domain protein
O1G22_RS39700	COG0477	Major facilitator Superfamily
O1G22_RS39705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O1G22_RS39715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O1G22_RS39720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1G22_RS39730	COG0457	Tetratricopeptide repeat
O1G22_RS39730	COG0463	Glycosyl transferase, family 2
O1G22_RS39745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O1G22_RS39770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1G22_RS39785	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
O1G22_RS39795	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS39800	COG4175	Glycine betaine
O1G22_RS39800	COG0517	IMP dehydrogenase activity
O1G22_RS39805	COG4176	ABC-type proline glycine betaine transport system permease component
O1G22_RS39820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O1G22_RS39825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O1G22_RS39855	COG1414	Transcriptional regulator
O1G22_RS39860	COG2271	Major facilitator Superfamily
O1G22_RS39875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1G22_RS39895	COG0509	glycine decarboxylation via glycine cleavage system
O1G22_RS39900	COG1760	l-serine dehydratase
O1G22_RS39905	COG0438	transferase activity, transferring glycosyl groups
O1G22_RS39910	COG0477	Major facilitator Superfamily
O1G22_RS39960	COG1309	transcriptional regulator
O1G22_RS39985	COG1609	Transcriptional regulator
O1G22_RS39995	COG1741	Belongs to the pirin family
O1G22_RS40000	COG1846	Transcriptional regulator
O1G22_RS40005	COG1902	pentaerythritol trinitrate reductase activity
O1G22_RS40020	COG0693	protein deglycase activity
O1G22_RS40025	COG0517	IMP dehydrogenase activity
O1G22_RS40045	COG1573	uracil-dna glycosylase
O1G22_RS40050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1G22_RS40060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O1G22_RS40065	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O1G22_RS40100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1G22_RS40135	COG0673	inositol 2-dehydrogenase activity
O1G22_RS40140	COG0673	inositol 2-dehydrogenase activity
O1G22_RS40145	COG0673	inositol 2-dehydrogenase activity
O1G22_RS40155	COG4257	antibiotic catabolic process
O1G22_RS40175	COG0640	Transcriptional regulator
O1G22_RS40230	COG0110	maltose O-acetyltransferase activity
O1G22_RS40285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1G22_RS40315	COG1063	alcohol dehydrogenase
O1G22_RS40320	COG0589	response to stress
O1G22_RS40330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1G22_RS40350	COG0517	IMP dehydrogenase activity
O1G22_RS40375	COG2267	carboxylic ester hydrolase activity
O1G22_RS40385	COG0517	IMP dehydrogenase activity
O1G22_RS40385	COG0516	GMP reductase activity
O1G22_RS40410	COG1063	alcohol dehydrogenase
O1G22_RS40420	COG0574	Belongs to the PEP-utilizing enzyme family
O1G22_RS40420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O1G22_RS40430	COG0517	IMP dehydrogenase activity
O1G22_RS40430	COG0516	GMP reductase activity
O1G22_RS40470	COG3261	NADH dehydrogenase
O1G22_RS40470	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
O1G22_RS40475	COG0651	ATP synthesis coupled electron transport
O1G22_RS40485	COG0650	Formate hydrogenlyase subunit 4
O1G22_RS40495	COG3260	NADH ubiquinone oxidoreductase 20
O1G22_RS40505	COG2824	Alkylphosphonate utilization operon protein PhnA
O1G22_RS40515	COG0659	secondary active sulfate transmembrane transporter activity
O1G22_RS40540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1G22_RS40545	COG2837	iron assimilation
O1G22_RS40565	COG0697	spore germination
O1G22_RS40590	COG2182	Extracellular solute-binding protein
O1G22_RS40625	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS40680	COG0515	serine threonine protein kinase
O1G22_RS40680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1G22_RS40755	COG1609	Transcriptional regulator
O1G22_RS40775	COG4977	sequence-specific DNA binding
O1G22_RS40780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O1G22_RS40785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O1G22_RS40790	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O1G22_RS40790	COG1082	Xylose isomerase domain protein TIM barrel
O1G22_RS40845	COG1181	Belongs to the D-alanine--D-alanine ligase family
O1G22_RS40850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1G22_RS40930	COG0583	DNA-binding transcription factor activity
O1G22_RS40950	COG1556	Lactate utilization protein
O1G22_RS40955	COG1139	Iron-sulfur cluster binding protein
O1G22_RS40960	COG0247	lactate metabolic process
O1G22_RS40980	COG0179	Fumarylacetoacetate (FAA) hydrolase
O1G22_RS40985	COG3254	rhamnose metabolic process
O1G22_RS40990	COG0395	ABC-type sugar transport system, permease component
O1G22_RS40995	COG1175	transmembrane transport
O1G22_RS41005	COG4948	Mandelate Racemase Muconate Lactonizing
O1G22_RS41010	COG2186	Transcriptional regulator
O1G22_RS41025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O1G22_RS41040	COG1070	Carbohydrate kinase
O1G22_RS41055	COG1175	transmembrane transport
O1G22_RS41060	COG0395	ABC-type sugar transport system, permease component
O1G22_RS41065	COG1609	Transcriptional regulator
O1G22_RS41085	COG0395	ABC-type sugar transport system, permease component
O1G22_RS41090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1G22_RS41100	COG2188	Transcriptional regulator
O1G22_RS41115	COG2084	Dehydrogenase
O1G22_RS41120	COG2610	gluconate transmembrane transporter activity
O1G22_RS41155	COG2267	carboxylic ester hydrolase activity
O1G22_RS41190	COG1414	Transcriptional regulator
O1G22_RS41195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O1G22_RS41200	COG0667	Aldo Keto reductase
O1G22_RS41215	COG4552	Acetyltransferase involved in intracellular survival and related
O1G22_RS41265	COG0783	Belongs to the Dps family
O1G22_RS41270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1G22_RS41285	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O1G22_RS41290	COG1335	isochorismatase
O1G22_RS41295	COG2259	Doxx family
O1G22_RS41300	COG3619	membrane
O1G22_RS41305	COG0028	Belongs to the TPP enzyme family
O1G22_RS41310	COG3608	succinylglutamate desuccinylase aspartoacylase
O1G22_RS41310	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O1G22_RS41335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O1G22_RS41340	COG4988	ABC transporter
O1G22_RS41350	COG1271	oxidase subunit
O1G22_RS41370	COG0395	ABC-type sugar transport system, permease component
O1G22_RS41375	COG1175	transmembrane transport
O1G22_RS41380	COG2182	Extracellular solute-binding protein
O1G22_RS41395	COG4977	sequence-specific DNA binding
O1G22_RS41395	COG1917	Cupin 2, conserved barrel domain protein
O1G22_RS41400	COG2197	response regulator
O1G22_RS41405	COG2814	Major facilitator Superfamily
O1G22_RS41425	COG0596	Alpha beta hydrolase
O1G22_RS41430	COG2267	carboxylic ester hydrolase activity
O1G22_RS41480	COG0604	alcohol dehydrogenase
O1G22_RS41480	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS41480	COG3321	synthase
O1G22_RS41485	COG3293	Transposase
O1G22_RS41520	COG1846	Transcriptional regulator
O1G22_RS41620	COG2801	Transposase and inactivated derivatives
O1G22_RS41620	COG3415	Transposase
O1G22_RS41640	COG3328	transposase activity
O1G22_RS41665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O1G22_RS41675	COG3293	Transposase
O1G22_RS41715	COG4195	phage-related replication protein
O1G22_RS41760	COG3850	Histidine kinase
O1G22_RS41760	COG0642	Histidine kinase
O1G22_RS41765	COG0745	RESPONSE REGULATOR receiver
O1G22_RS41830	COG0604	alcohol dehydrogenase
O1G22_RS41860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O1G22_RS41890	COG3328	transposase activity
O1G22_RS41945	COG2076	Multidrug Resistance protein
O1G22_RS41950	COG1309	transcriptional regulator
O1G22_RS41955	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS41960	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS42010	COG0038	chloride channel
O1G22_RS42035	COG1309	transcriptional regulator
O1G22_RS42080	COG4974	Belongs to the 'phage' integrase family
O1G22_RS42095	COG2801	Transposase and inactivated derivatives
O1G22_RS42135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O1G22_RS42145	COG0577	efflux transmembrane transporter activity
O1G22_RS42145	COG1136	(ABC) transporter
O1G22_RS42150	COG4585	Histidine kinase
O1G22_RS42155	COG2197	response regulator
O1G22_RS42200	COG0174	glutamine synthetase
O1G22_RS42215	COG4689	acetoacetate decarboxylase
O1G22_RS42235	COG1309	transcriptional regulator
O1G22_RS42260	COG0519	Catalyzes the synthesis of GMP from XMP
O1G22_RS42260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O1G22_RS42265	COG1012	belongs to the aldehyde dehydrogenase family
O1G22_RS42270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O1G22_RS42280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O1G22_RS42290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O1G22_RS42305	COG1846	Transcriptional regulator
O1G22_RS42340	COG4974	Belongs to the 'phage' integrase family
O1G22_RS42445	COG1309	transcriptional regulator
O1G22_RS42465	COG0587	DNA-directed DNA polymerase activity
O1G22_RS42525	COG1247	-acetyltransferase
O1G22_RS42530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1G22_RS42540	COG0640	Transcriptional regulator
O1G22_RS42570	COG1970	mechanosensitive ion channel activity
O1G22_RS42620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O1G22_RS42630	COG1301	dicarboxylic acid transport
O1G22_RS42640	COG1802	Transcriptional regulator
O1G22_RS42670	COG2318	DinB family
O1G22_RS42680	COG3328	transposase activity
O1G22_RS42705	COG1073	alpha beta
O1G22_RS42715	COG3321	synthase
O1G22_RS42715	COG0604	alcohol dehydrogenase
O1G22_RS42725	COG2197	response regulator
O1G22_RS42730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1G22_RS42735	COG1960	acyl-CoA dehydrogenase activity
O1G22_RS42780	COG1309	transcriptional regulator
O1G22_RS42875	COG4584	PFAM Integrase catalytic
O1G22_RS42895	COG1484	DNA-dependent DNA replication
O1G22_RS42930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O1G22_RS42940	COG1309	transcriptional regulator
O1G22_RS42950	COG0604	alcohol dehydrogenase
O1G22_RS42960	COG4974	Belongs to the 'phage' integrase family
O1G22_RS42965	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O1G22_RS43155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1G22_RS43165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1G22_RS43180	COG2197	response regulator
O1G22_RS43185	COG4585	Histidine kinase
O1G22_RS43205	COG0702	epimerase
O1G22_RS43220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O1G22_RS43225	COG2124	cytochrome p450
O1G22_RS43235	COG0477	Major facilitator Superfamily
O1G22_RS43240	COG0745	RESPONSE REGULATOR receiver
O1G22_RS43260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1G22_RS43265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1G22_RS43330	COG1192	Involved in chromosome partitioning
O1G22_RS43370	COG0702	epimerase
O1G22_RS43385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1G22_RS43440	COG3424	synthase
O1G22_RS43460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O1G22_RS43470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O1G22_RS43535	COG0477	Major facilitator Superfamily
O1G22_RS43570	COG4106	trans-aconitate 2-methyltransferase activity
O1G22_RS43575	COG3246	L-lysine catabolic process to acetate
O1G22_RS43580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1G22_RS43580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1G22_RS43585	COG0405	Gamma-glutamyltransferase
O1G22_RS43595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1G22_RS43600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1G22_RS43605	COG0655	NAD(P)H dehydrogenase (quinone) activity
O1G22_RS43610	COG1131	(ABC) transporter
O1G22_RS43625	COG1501	Belongs to the glycosyl hydrolase 31 family
O1G22_RS43660	COG1032	radical SAM domain protein
O1G22_RS43665	COG0318	PFAM AMP-dependent synthetase and ligase
O1G22_RS43670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1G22_RS43675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1G22_RS43705	COG2050	protein possibly involved in aromatic compounds catabolism
O1G22_RS43730	COG1595	DNA-templated transcription, initiation
O1G22_RS43735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1G22_RS43750	COG0142	geranyltranstransferase activity
O1G22_RS43815	COG3425	synthase
O1G22_RS43865	COG3903	Transcriptional regulator
O1G22_RS43865	COG3629	intracellular signal transduction
O1G22_RS43875	COG1595	DNA-templated transcription, initiation
O1G22_RS43880	COG3424	synthase
O1G22_RS43890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O1G22_RS43900	COG0655	NAD(P)H dehydrogenase (quinone) activity
O1G22_RS43910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O1G22_RS43940	COG2318	DinB family
O1G22_RS43945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O1G22_RS43960	COG1271	oxidase subunit
O1G22_RS43965	COG0583	DNA-binding transcription factor activity
O1G22_RS43970	COG0633	Ferredoxin
O1G22_RS44050	COG0583	DNA-binding transcription factor activity
O1G22_RS44060	COG1595	DNA-templated transcription, initiation
O1G22_RS44080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1G22_RS44210	COG0189	ligase activity
O1G22_RS44225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O1G22_RS44230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1G22_RS44235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O1G22_RS44240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O1G22_RS44245	COG0531	amino acid
O1G22_RS44250	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS44260	COG3903	Transcriptional regulator
O1G22_RS44260	COG3629	intracellular signal transduction
O1G22_RS44310	COG1028	Short-chain dehydrogenase reductase Sdr
O1G22_RS44330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O1G22_RS44370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O1G22_RS44375	COG0254	rRNA binding
O1G22_RS44380	COG0267	Belongs to the bacterial ribosomal protein bL33 family