locus-tag	class	description
F1D59_RS00025	COG1733	regulation of RNA biosynthetic process
F1D59_RS00035	COG2910	NAD(P)H-binding
F1D59_RS00040	COG2814	Major facilitator Superfamily
F1D59_RS00075	COG0745	RESPONSE REGULATOR receiver
F1D59_RS00080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1D59_RS00090	COG1088	dTDP-glucose 4,6-dehydratase activity
F1D59_RS00135	COG0154	amidase activity
F1D59_RS00140	COG1428	Deoxynucleoside kinase
F1D59_RS00205	COG0477	Major facilitator Superfamily
F1D59_RS00270	COG0596	Alpha beta hydrolase
F1D59_RS00285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS00325	COG4213	ABC transporter substrate-binding protein
F1D59_RS00360	COG2226	methyltransferase
F1D59_RS00365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1D59_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS00490	COG0698	ribose 5-phosphate isomerase
F1D59_RS00495	COG2814	Major facilitator Superfamily
F1D59_RS00535	COG0515	serine threonine protein kinase
F1D59_RS00615	COG1473	amidohydrolase
F1D59_RS00665	COG4176	ABC-type proline glycine betaine transport system permease component
F1D59_RS00670	COG4175	Glycine betaine
F1D59_RS00670	COG0517	IMP dehydrogenase activity
F1D59_RS00680	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS00685	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F1D59_RS00690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1D59_RS00715	COG1764	response to oxidative stress
F1D59_RS00755	COG0702	epimerase
F1D59_RS00760	COG3631	Ketosteroid isomerase-related protein
F1D59_RS00815	COG0557	exoribonuclease II activity
F1D59_RS00985	COG1309	transcriptional regulator
F1D59_RS00990	COG0300	oxidoreductase activity
F1D59_RS01010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1D59_RS01030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F1D59_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS01050	COG0038	chloride channel
F1D59_RS01060	COG2409	Drug exporters of the RND superfamily
F1D59_RS01075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1D59_RS01095	COG1595	DNA-templated transcription, initiation
F1D59_RS01115	COG0596	Alpha beta hydrolase
F1D59_RS01140	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
F1D59_RS01165	COG4977	sequence-specific DNA binding
F1D59_RS01180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1D59_RS01190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1D59_RS01195	COG2011	ABC-type metal ion transport system permease component
F1D59_RS01210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F1D59_RS01215	COG0477	Major facilitator Superfamily
F1D59_RS01255	COG0583	DNA-binding transcription factor activity
F1D59_RS01265	COG1024	Enoyl-CoA hydratase
F1D59_RS01300	COG4106	trans-aconitate 2-methyltransferase activity
F1D59_RS01305	COG1940	carbohydrate kinase activity
F1D59_RS01305	COG1846	Transcriptional regulator
F1D59_RS01315	COG1175	transmembrane transport
F1D59_RS01320	COG0395	ABC-type sugar transport system, permease component
F1D59_RS01395	COG3290	protein histidine kinase activity
F1D59_RS01420	COG0308	aminopeptidase N
F1D59_RS01425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS01455	COG1191	sigma factor activity
F1D59_RS01465	COG1366	Belongs to the anti-sigma-factor antagonist family
F1D59_RS01485	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
F1D59_RS01490	COG0477	Major facilitator Superfamily
F1D59_RS01495	COG0745	RESPONSE REGULATOR receiver
F1D59_RS01500	COG2205	protein histidine kinase activity
F1D59_RS01505	COG0515	serine threonine protein kinase
F1D59_RS01505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1D59_RS01530	COG2267	carboxylic ester hydrolase activity
F1D59_RS01545	COG1228	amidohydrolase
F1D59_RS01560	COG4106	trans-aconitate 2-methyltransferase activity
F1D59_RS01580	COG0009	L-threonylcarbamoyladenylate synthase
F1D59_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS01620	COG0328	RNA-DNA hybrid ribonuclease activity
F1D59_RS01635	COG1278	Cold shock
F1D59_RS01645	COG1595	DNA-templated transcription, initiation
F1D59_RS01700	COG0583	DNA-binding transcription factor activity
F1D59_RS01725	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS01750	COG4941	Belongs to the sigma-70 factor family
F1D59_RS01775	COG1686	Belongs to the peptidase S11 family
F1D59_RS01805	COG1764	response to oxidative stress
F1D59_RS01810	COG1846	Transcriptional regulator
F1D59_RS01815	COG1796	DNA polymerase
F1D59_RS01815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F1D59_RS01830	COG1755	Isoprenylcysteine carboxyl methyltransferase
F1D59_RS01845	COG2272	Belongs to the type-B carboxylesterase lipase family
F1D59_RS01880	COG0714	Associated with various cellular activities
F1D59_RS01915	COG3391	amine dehydrogenase activity
F1D59_RS02000	COG0583	DNA-binding transcription factor activity
F1D59_RS02010	COG3973	AAA domain
F1D59_RS02015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1D59_RS02030	COG2197	response regulator
F1D59_RS02035	COG2203	Gaf domain
F1D59_RS02035	COG4585	Histidine kinase
F1D59_RS02040	COG2409	Drug exporters of the RND superfamily
F1D59_RS02045	COG4176	ABC-type proline glycine betaine transport system permease component
F1D59_RS02050	COG3448	diguanylate cyclase activity
F1D59_RS02050	COG4175	Glycine betaine
F1D59_RS02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1D59_RS02065	COG4264	IucA IucC family
F1D59_RS02070	COG2226	methyltransferase
F1D59_RS02090	COG0277	FAD linked oxidase domain protein
F1D59_RS02110	COG4585	Histidine kinase
F1D59_RS02115	COG2197	response regulator
F1D59_RS02145	COG1132	(ABC) transporter
F1D59_RS02180	COG2249	NAD(P)H dehydrogenase (quinone) activity
F1D59_RS02195	COG3629	intracellular signal transduction
F1D59_RS02195	COG3903	Transcriptional regulator
F1D59_RS02215	COG0494	nUDIX hydrolase
F1D59_RS02245	COG3265	gluconokinase activity
F1D59_RS02260	COG2124	cytochrome p450
F1D59_RS02270	COG1404	Belongs to the peptidase S8 family
F1D59_RS02270	COG4412	M6 family metalloprotease domain protein
F1D59_RS02315	COG1793	dna ligase
F1D59_RS02320	COG1131	(ABC) transporter
F1D59_RS02330	COG0667	Aldo Keto reductase
F1D59_RS02370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS02375	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F1D59_RS02375	COG1672	PFAM Archaeal ATPase
F1D59_RS02385	COG4249	Peptidase C14 caspase catalytic subunit p20
F1D59_RS02385	COG2319	Wd-40 repeat
F1D59_RS02400	COG3655	Transcriptional regulator
F1D59_RS02445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1D59_RS02460	COG1309	transcriptional regulator
F1D59_RS02495	COG0800	Aldolase
F1D59_RS02500	COG1414	Transcriptional regulator
F1D59_RS02515	COG0076	glutamate decarboxylase activity
F1D59_RS02530	COG0789	Transcriptional regulator
F1D59_RS02550	COG4565	transcriptional regulatory protein
F1D59_RS02555	COG3290	protein histidine kinase activity
F1D59_RS02560	COG1301	dicarboxylic acid transport
F1D59_RS02585	COG2267	carboxylic ester hydrolase activity
F1D59_RS02600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F1D59_RS02620	COG2304	oxidoreductase activity
F1D59_RS02640	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS02645	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS02665	COG1024	Enoyl-CoA hydratase
F1D59_RS02705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1D59_RS02720	COG0515	serine threonine protein kinase
F1D59_RS02720	COG2815	serine threonine protein kinase
F1D59_RS02730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F1D59_RS02760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1D59_RS02770	COG2356	endonuclease I
F1D59_RS02780	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F1D59_RS02790	COG2814	Major facilitator Superfamily
F1D59_RS02825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1D59_RS02830	COG0393	Putative heavy-metal-binding
F1D59_RS02920	COG4733	cellulase activity
F1D59_RS02920	COG5297	Belongs to the glycosyl hydrolase family 6
F1D59_RS02945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1D59_RS02965	COG2909	trisaccharide binding
F1D59_RS02985	COG0456	acetyltransferase
F1D59_RS02985	COG0454	-acetyltransferase
F1D59_RS03025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1D59_RS03035	COG2080	2 iron, 2 sulfur cluster binding
F1D59_RS03035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F1D59_RS03050	COG0346	lactoylglutathione lyase activity
F1D59_RS03055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1D59_RS03110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1D59_RS03120	COG1309	transcriptional regulator
F1D59_RS03125	COG0667	Aldo Keto reductase
F1D59_RS03130	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS03140	COG3842	ATPase activity
F1D59_RS03145	COG1177	transmembrane transport
F1D59_RS03150	COG1176	ABC-type spermidine putrescine transport system, permease component I
F1D59_RS03170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1D59_RS03180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1D59_RS03180	COG1042	CoA-binding domain protein
F1D59_RS03180	COG0045	succinate-CoA ligase (ADP-forming) activity
F1D59_RS03185	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS03190	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS03200	COG1309	transcriptional regulator
F1D59_RS03210	COG1309	transcriptional regulator
F1D59_RS03215	COG0277	FAD linked oxidase domain protein
F1D59_RS03390	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F1D59_RS03435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1D59_RS03450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1D59_RS03470	COG1191	sigma factor activity
F1D59_RS03505	COG2382	esterase
F1D59_RS03515	COG1132	(ABC) transporter
F1D59_RS03525	COG1132	(ABC) transporter
F1D59_RS03530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1D59_RS03535	COG1120	ATPase activity
F1D59_RS03540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1D59_RS03545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1D59_RS03550	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F1D59_RS03565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F1D59_RS03595	COG2409	Drug exporters of the RND superfamily
F1D59_RS03600	COG4585	Histidine kinase
F1D59_RS03605	COG2197	response regulator
F1D59_RS03625	COG2814	Major facilitator Superfamily
F1D59_RS03715	COG3629	intracellular signal transduction
F1D59_RS03715	COG3903	Transcriptional regulator
F1D59_RS03745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1D59_RS03780	COG2226	methyltransferase
F1D59_RS03785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1D59_RS03820	COG4221	oxidoreductase activity
F1D59_RS03895	COG0667	Aldo Keto reductase
F1D59_RS03920	COG0515	serine threonine protein kinase
F1D59_RS03920	COG2815	serine threonine protein kinase
F1D59_RS03940	COG1073	alpha beta
F1D59_RS03940	COG2226	methyltransferase
F1D59_RS03945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1D59_RS03960	COG3415	Transposase
F1D59_RS03960	COG2801	Transposase and inactivated derivatives
F1D59_RS03980	COG2205	protein histidine kinase activity
F1D59_RS04005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1D59_RS04010	COG4044	May play a role in the intracellular transport of hydrophobic ligands
F1D59_RS04030	COG1595	DNA-templated transcription, initiation
F1D59_RS04055	COG0604	alcohol dehydrogenase
F1D59_RS04060	COG1476	TRANSCRIPTIONal
F1D59_RS04070	COG2135	peptidase activity
F1D59_RS04095	COG4585	Histidine kinase
F1D59_RS04100	COG2197	response regulator
F1D59_RS04160	COG1074	ATP-dependent DNA helicase activity
F1D59_RS04185	COG2217	Heavy metal translocating P-type atpase
F1D59_RS04195	COG1309	transcriptional regulator
F1D59_RS04260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1D59_RS04305	COG2226	methyltransferase
F1D59_RS04310	COG1937	Protein conserved in bacteria
F1D59_RS04385	COG2813	Specifically methylates the guanine in position
F1D59_RS04415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F1D59_RS04435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1D59_RS04440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1D59_RS04450	COG0183	Belongs to the thiolase family
F1D59_RS04455	COG1609	Transcriptional regulator
F1D59_RS04485	COG4122	O-methyltransferase activity
F1D59_RS04500	COG3572	ergothioneine biosynthetic process
F1D59_RS04505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1D59_RS04510	COG0121	glutamine amidotransferase
F1D59_RS04515	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F1D59_RS04530	COG2182	Extracellular solute-binding protein
F1D59_RS04535	COG3360	Dodecin
F1D59_RS04545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS04575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F1D59_RS04580	COG1053	succinate dehydrogenase
F1D59_RS04590	COG0583	DNA-binding transcription factor activity
F1D59_RS04595	COG1309	transcriptional regulator
F1D59_RS04670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1D59_RS04725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F1D59_RS04740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F1D59_RS04785	COG1957	nucleoside hydrolase
F1D59_RS04840	COG3835	regulator
F1D59_RS04845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F1D59_RS04850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F1D59_RS04850	COG2080	2 iron, 2 sulfur cluster binding
F1D59_RS04880	COG2304	oxidoreductase activity
F1D59_RS04885	COG1136	(ABC) transporter
F1D59_RS04885	COG0577	efflux transmembrane transporter activity
F1D59_RS04905	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS04975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1D59_RS05005	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1D59_RS05005	COG1902	pentaerythritol trinitrate reductase activity
F1D59_RS05015	COG0395	ABC-type sugar transport system, permease component
F1D59_RS05020	COG1175	transmembrane transport
F1D59_RS05025	COG1653	transport
F1D59_RS05045	COG0589	response to stress
F1D59_RS05060	COG3345	alpha-galactosidase
F1D59_RS05075	COG0142	geranyltranstransferase activity
F1D59_RS05105	COG0583	DNA-binding transcription factor activity
F1D59_RS05110	COG0604	alcohol dehydrogenase
F1D59_RS05110	COG3321	synthase
F1D59_RS05115	COG3321	synthase
F1D59_RS05115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS05135	COG4106	trans-aconitate 2-methyltransferase activity
F1D59_RS05145	COG3511	phospholipase C
F1D59_RS05165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1D59_RS05185	COG1335	isochorismatase
F1D59_RS05195	COG1231	oxidoreductase activity
F1D59_RS05205	COG1132	(ABC) transporter
F1D59_RS05210	COG2124	cytochrome p450
F1D59_RS05235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1D59_RS05270	COG2890	protein-(glutamine-N5) methyltransferase activity
F1D59_RS05275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F1D59_RS05275	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1D59_RS05285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F1D59_RS05310	COG3629	intracellular signal transduction
F1D59_RS05310	COG3903	Transcriptional regulator
F1D59_RS05320	COG1834	amidinotransferase
F1D59_RS05355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS05360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS05370	COG0069	glutamate synthase activity
F1D59_RS05375	COG0017	Asparaginyl-tRNA synthetase
F1D59_RS05380	COG4865	methylaspartate mutase activity
F1D59_RS05400	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS05405	COG2327	Polysaccharide pyruvyl transferase
F1D59_RS05415	COG0297	glycogen (starch) synthase activity
F1D59_RS05455	COG0346	lactoylglutathione lyase activity
F1D59_RS05460	COG1556	Lactate utilization protein
F1D59_RS05465	COG1139	Iron-sulfur cluster binding protein
F1D59_RS05470	COG0247	lactate metabolic process
F1D59_RS05505	COG2838	Isocitrate dehydrogenase
F1D59_RS05510	COG3152	Membrane
F1D59_RS05525	COG0598	Magnesium transport protein CorA
F1D59_RS05535	COG0583	DNA-binding transcription factor activity
F1D59_RS05560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1D59_RS05585	COG1172	Belongs to the binding-protein-dependent transport system permease family
F1D59_RS05610	COG2124	cytochrome p450
F1D59_RS05695	COG2755	lipolytic protein G-D-S-L family
F1D59_RS05735	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F1D59_RS05745	COG1562	ergosterol biosynthetic process
F1D59_RS05750	COG1134	teichoic acid transport
F1D59_RS05770	COG0371	Dehydrogenase
F1D59_RS05790	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F1D59_RS05805	COG1024	Enoyl-CoA hydratase
F1D59_RS05815	COG0488	(ABC) transporter
F1D59_RS05820	COG0300	oxidoreductase activity
F1D59_RS05865	COG0789	Transcriptional regulator
F1D59_RS05885	COG0183	Belongs to the thiolase family
F1D59_RS05890	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS05895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS05900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1D59_RS05910	COG3268	Saccharopine dehydrogenase
F1D59_RS05915	COG1515	deoxyribonuclease V activity
F1D59_RS05935	COG0488	(ABC) transporter
F1D59_RS05985	COG1793	dna ligase
F1D59_RS06005	COG0494	nUDIX hydrolase
F1D59_RS06010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1D59_RS06025	COG1486	melibiose metabolic process
F1D59_RS06065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1D59_RS06090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1D59_RS06095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F1D59_RS06135	COG0656	L-ascorbic acid biosynthetic process
F1D59_RS06150	COG2154	pterin-4-alpha-carbinolamine dehydratase
F1D59_RS06190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F1D59_RS06200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1D59_RS06220	COG0531	amino acid
F1D59_RS06265	COG2226	methyltransferase
F1D59_RS06270	COG0457	Tetratricopeptide repeat
F1D59_RS06305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1D59_RS06310	COG2362	D-Aminopeptidase
F1D59_RS06335	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1D59_RS06345	COG0604	alcohol dehydrogenase
F1D59_RS06350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS06350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS06365	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS06370	COG0688	phosphatidylethanolamine metabolic process
F1D59_RS06385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1D59_RS06405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F1D59_RS06410	COG1929	Belongs to the glycerate kinase type-1 family
F1D59_RS06425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1D59_RS06430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1D59_RS06435	COG1448	Aminotransferase
F1D59_RS06450	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F1D59_RS06460	COG0483	inositol monophosphate 1-phosphatase activity
F1D59_RS06475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1D59_RS06480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1D59_RS06515	COG0405	Gamma-glutamyltransferase
F1D59_RS06535	COG2205	protein histidine kinase activity
F1D59_RS06540	COG0745	RESPONSE REGULATOR receiver
F1D59_RS06565	COG1126	abc transporter atp-binding protein
F1D59_RS06590	COG1940	carbohydrate kinase activity
F1D59_RS06610	COG0673	inositol 2-dehydrogenase activity
F1D59_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS06645	COG4266	Belongs to the allantoicase family
F1D59_RS06650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1D59_RS06655	COG1414	Transcriptional regulator
F1D59_RS06660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1D59_RS06675	COG2197	response regulator
F1D59_RS06685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1D59_RS06695	COG0746	molybdenum cofactor guanylyltransferase activity
F1D59_RS06700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F1D59_RS06730	COG2233	PERMEase
F1D59_RS06745	COG2351	hydroxyisourate hydrolase activity
F1D59_RS06765	COG3622	Belongs to the hyi family
F1D59_RS06770	COG2084	Dehydrogenase
F1D59_RS06775	COG0753	catalase activity
F1D59_RS06790	COG3960	tartronate-semialdehyde synthase activity
F1D59_RS06800	COG0386	Belongs to the glutathione peroxidase family
F1D59_RS06805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1D59_RS06815	COG0598	Magnesium transport protein CorA
F1D59_RS06885	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F1D59_RS06890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F1D59_RS06895	COG0375	protein maturation
F1D59_RS06935	COG1024	Enoyl-CoA hydratase
F1D59_RS06935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1D59_RS06955	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS06985	COG1088	dTDP-glucose 4,6-dehydratase activity
F1D59_RS07030	COG0463	Glycosyl transferase, family 2
F1D59_RS07060	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F1D59_RS07080	COG2211	Major facilitator Superfamily
F1D59_RS07090	COG3629	intracellular signal transduction
F1D59_RS07090	COG3903	Transcriptional regulator
F1D59_RS07100	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS07110	COG2197	response regulator
F1D59_RS07110	COG3903	Transcriptional regulator
F1D59_RS07115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F1D59_RS07145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1D59_RS07155	COG3321	synthase
F1D59_RS07155	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS07155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS07155	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS07155	COG0300	oxidoreductase activity
F1D59_RS07165	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS07170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1D59_RS07290	COG4552	Acetyltransferase involved in intracellular survival and related
F1D59_RS07305	COG2252	PERMEase
F1D59_RS07335	COG1802	Transcriptional regulator
F1D59_RS07360	COG0028	Belongs to the TPP enzyme family
F1D59_RS07370	COG1404	Belongs to the peptidase S8 family
F1D59_RS07400	COG1162	GTPase activity
F1D59_RS07430	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS07440	COG0456	acetyltransferase
F1D59_RS07455	COG0175	sulfate reduction
F1D59_RS07460	COG0529	Catalyzes the synthesis of activated sulfate
F1D59_RS07480	COG1116	anion transmembrane transporter activity
F1D59_RS07485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F1D59_RS07495	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F1D59_RS07565	COG0583	DNA-binding transcription factor activity
F1D59_RS07570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1D59_RS07605	COG0504	CTP synthase activity
F1D59_RS07625	COG3511	phospholipase C
F1D59_RS07630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1D59_RS07635	COG0463	Glycosyl transferase, family 2
F1D59_RS07680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1D59_RS07685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1D59_RS07715	COG2124	cytochrome p450
F1D59_RS07740	COG4152	abc transporter atp-binding protein
F1D59_RS07755	COG3220	belongs to the UPF0276 family
F1D59_RS07765	COG0596	Alpha beta hydrolase
F1D59_RS07770	COG3253	May function as heme-dependent peroxidase
F1D59_RS07775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F1D59_RS07785	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1D59_RS07790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F1D59_RS07805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F1D59_RS07815	COG0183	Belongs to the thiolase family
F1D59_RS07820	COG1024	Enoyl-CoA hydratase
F1D59_RS07820	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1D59_RS07825	COG1316	TRANSCRIPTIONal
F1D59_RS07830	COG0531	amino acid
F1D59_RS07835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F1D59_RS07840	COG4214	carbohydrate transport
F1D59_RS07850	COG4213	ABC transporter substrate-binding protein
F1D59_RS07855	COG1940	carbohydrate kinase activity
F1D59_RS07870	COG0395	ABC-type sugar transport system, permease component
F1D59_RS07875	COG1175	transmembrane transport
F1D59_RS07880	COG1653	transport
F1D59_RS07895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1D59_RS07925	COG2207	Transcriptional regulator
F1D59_RS07925	COG3708	Transcriptional regulator
F1D59_RS07965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1D59_RS07975	COG4608	Belongs to the ABC transporter superfamily
F1D59_RS07990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1D59_RS08020	COG3938	Belongs to the proline racemase family
F1D59_RS08040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1D59_RS08050	COG0006	proline dipeptidase activity
F1D59_RS08080	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F1D59_RS08085	COG2350	Protein conserved in bacteria
F1D59_RS08095	COG4249	Peptidase C14 caspase catalytic subunit p20
F1D59_RS08095	COG2319	Wd-40 repeat
F1D59_RS08105	COG2192	nodulation
F1D59_RS08115	COG1024	Enoyl-CoA hydratase
F1D59_RS08125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1D59_RS08140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F1D59_RS08155	COG2040	homocysteine
F1D59_RS08190	COG1799	cell septum assembly
F1D59_RS08205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS08210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F1D59_RS08225	COG0431	NADPH-dependent FMN reductase
F1D59_RS08235	COG1940	carbohydrate kinase activity
F1D59_RS08260	COG0252	asparaginase activity
F1D59_RS08270	COG2409	Drug exporters of the RND superfamily
F1D59_RS08275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1D59_RS08300	COG0436	Aminotransferase
F1D59_RS08365	COG0604	alcohol dehydrogenase
F1D59_RS08365	COG3321	synthase
F1D59_RS08390	COG0644	oxidoreductase
F1D59_RS08395	COG2124	cytochrome p450
F1D59_RS08400	COG2124	cytochrome p450
F1D59_RS08440	COG1834	amidinotransferase
F1D59_RS08455	COG4221	oxidoreductase activity
F1D59_RS08540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F1D59_RS08545	COG0531	amino acid
F1D59_RS08550	COG0569	domain protein
F1D59_RS08585	COG0756	dUTP diphosphatase activity
F1D59_RS08610	COG2205	protein histidine kinase activity
F1D59_RS08615	COG0745	RESPONSE REGULATOR receiver
F1D59_RS08630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F1D59_RS08675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1D59_RS08680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F1D59_RS08725	COG2017	converts alpha-aldose to the beta-anomer
F1D59_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS08745	COG1271	oxidase subunit
F1D59_RS08760	COG3387	PFAM Glycoside hydrolase 15-related
F1D59_RS08770	COG1435	thymidine kinase activity
F1D59_RS08790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F1D59_RS08795	COG1802	Transcriptional regulator
F1D59_RS08810	COG0612	Peptidase, M16
F1D59_RS08815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1D59_RS08835	COG0372	Belongs to the citrate synthase family
F1D59_RS08845	COG3290	protein histidine kinase activity
F1D59_RS08850	COG4565	transcriptional regulatory protein
F1D59_RS08855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1D59_RS08880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1D59_RS08890	COG1136	(ABC) transporter
F1D59_RS08945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS08985	COG1819	glycosyl
F1D59_RS08995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS09000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS09005	COG2867	negative regulation of translational initiation
F1D59_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS09040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F1D59_RS09085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1D59_RS09090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F1D59_RS09095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1D59_RS09130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F1D59_RS09140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1D59_RS09145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F1D59_RS09155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F1D59_RS09175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1D59_RS09190	COG1609	Transcriptional regulator
F1D59_RS09205	COG2205	protein histidine kinase activity
F1D59_RS09215	COG1126	abc transporter atp-binding protein
F1D59_RS09220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1D59_RS09225	COG0765	amino acid transport
F1D59_RS09230	COG0765	amino acid transport
F1D59_RS09235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1D59_RS09260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F1D59_RS09270	COG1619	proteins homologs of microcin C7 resistance protein MccF
F1D59_RS09310	COG2207	Transcriptional regulator
F1D59_RS09310	COG1917	Cupin 2, conserved barrel domain protein
F1D59_RS09315	COG1201	RNA secondary structure unwinding
F1D59_RS09320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1D59_RS09325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1D59_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS09335	COG1396	sequence-specific DNA binding
F1D59_RS09340	COG1058	Belongs to the CinA family
F1D59_RS09340	COG1546	Belongs to the CinA family
F1D59_RS09350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1D59_RS09360	COG1674	ftsk spoiiie
F1D59_RS09370	COG2205	protein histidine kinase activity
F1D59_RS09370	COG3437	response regulator, receiver
F1D59_RS09370	COG4999	Histidine kinase
F1D59_RS09370	COG3850	Histidine kinase
F1D59_RS09375	COG2208	phosphoserine phosphatase activity
F1D59_RS09375	COG2770	Histidine kinase
F1D59_RS09380	COG2318	DinB family
F1D59_RS09405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F1D59_RS09410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1D59_RS09415	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F1D59_RS09435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F1D59_RS09440	COG0612	Peptidase, M16
F1D59_RS09445	COG1185	polyribonucleotide nucleotidyltransferase activity
F1D59_RS09450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F1D59_RS09460	COG1674	ftsk spoiiie
F1D59_RS09480	COG1404	Belongs to the peptidase S8 family
F1D59_RS09500	COG0455	bacterial-type flagellum organization
F1D59_RS09515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F1D59_RS09520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F1D59_RS09530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1D59_RS09545	COG0779	Required for maturation of 30S ribosomal subunits
F1D59_RS09565	COG0330	HflC and HflK could
F1D59_RS09570	COG0442	prolyl-tRNA aminoacylation
F1D59_RS09585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F1D59_RS09590	COG0750	zinc metalloprotease
F1D59_RS09595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F1D59_RS09610	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS09615	COG2508	Transcriptional regulator
F1D59_RS09645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1D59_RS09650	COG1177	transmembrane transport
F1D59_RS09655	COG1176	ABC-type spermidine putrescine transport system, permease component I
F1D59_RS09660	COG3842	ATPase activity
F1D59_RS09690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F1D59_RS09700	COG4585	Histidine kinase
F1D59_RS09705	COG2197	response regulator
F1D59_RS09725	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS09735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F1D59_RS09740	COG1136	(ABC) transporter
F1D59_RS09780	COG3842	ATPase activity
F1D59_RS09795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F1D59_RS09805	COG0233	cytoplasmic translational termination
F1D59_RS09810	COG0528	UMP kinase activity
F1D59_RS09815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F1D59_RS09820	COG0052	Belongs to the universal ribosomal protein uS2 family
F1D59_RS09835	COG1191	sigma factor activity
F1D59_RS09850	COG0792	nuclease activity
F1D59_RS09875	COG0681	Belongs to the peptidase S26 family
F1D59_RS09885	COG0335	large ribosomal subunit rRNA binding
F1D59_RS09890	COG0336	Belongs to the RNA methyltransferase TrmD family
F1D59_RS09895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F1D59_RS09900	COG1837	Belongs to the UPF0109 family
F1D59_RS09905	COG0228	four-way junction DNA binding
F1D59_RS09915	COG0442	prolyl-tRNA aminoacylation
F1D59_RS09930	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F1D59_RS09970	COG0477	Major facilitator Superfamily
F1D59_RS09975	COG1196	nuclear chromosome segregation
F1D59_RS09985	COG1254	Belongs to the acylphosphatase family
F1D59_RS09990	COG2340	Cysteine-rich secretory protein family
F1D59_RS10000	COG1733	regulation of RNA biosynthetic process
F1D59_RS10005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1D59_RS10010	COG0571	ribonuclease III activity
F1D59_RS10015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F1D59_RS10030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F1D59_RS10035	COG0742	ribosomal rna small subunit methyltransferase
F1D59_RS10040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F1D59_RS10045	COG1461	Dihydroxyacetone kinase
F1D59_RS10050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1D59_RS10055	COG0351	phosphomethylpyrimidine kinase
F1D59_RS10075	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1D59_RS10080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1D59_RS10090	COG1920	GTP binding
F1D59_RS10095	COG0776	regulation of translation
F1D59_RS10105	COG0066	3-isopropylmalate dehydratase activity
F1D59_RS10110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1D59_RS10145	COG1011	Hydrolase
F1D59_RS10155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1D59_RS10160	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1D59_RS10170	COG5002	protein histidine kinase activity
F1D59_RS10175	COG2018	Roadblock/LC7 domain
F1D59_RS10195	COG2018	Roadblock/LC7 domain
F1D59_RS10215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1D59_RS10220	COG2353	YceI-like domain
F1D59_RS10230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1D59_RS10240	COG2957	Belongs to the agmatine deiminase family
F1D59_RS10245	COG0804	urea catabolic process
F1D59_RS10250	COG0832	Belongs to the urease beta subunit family
F1D59_RS10250	COG0831	urea catabolic process
F1D59_RS10260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1D59_RS10265	COG0473	3-isopropylmalate dehydrogenase activity
F1D59_RS10270	COG0583	DNA-binding transcription factor activity
F1D59_RS10275	COG2130	NADP-dependent
F1D59_RS10280	COG3511	phospholipase C
F1D59_RS10295	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS10300	COG0506	proline dehydrogenase activity
F1D59_RS10320	COG0477	Major facilitator Superfamily
F1D59_RS10325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1D59_RS10330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1D59_RS10335	COG0440	acetolactate synthase activity
F1D59_RS10355	COG0667	Aldo Keto reductase
F1D59_RS10360	COG2133	pyrroloquinoline quinone binding
F1D59_RS10370	COG2197	response regulator
F1D59_RS10385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1D59_RS10390	COG2409	Drug exporters of the RND superfamily
F1D59_RS10405	COG2318	DinB family
F1D59_RS10410	COG1132	(ABC) transporter
F1D59_RS10410	COG2375	cellular response to nickel ion
F1D59_RS10440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1D59_RS10450	COG0154	amidase activity
F1D59_RS10455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1D59_RS10465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1D59_RS10490	COG4977	sequence-specific DNA binding
F1D59_RS10500	COG0482	sulfurtransferase activity
F1D59_RS10505	COG3023	N-Acetylmuramoyl-L-alanine amidase
F1D59_RS10520	COG2860	membrane
F1D59_RS10525	COG4608	Belongs to the ABC transporter superfamily
F1D59_RS10530	COG0444	Belongs to the ABC transporter superfamily
F1D59_RS10540	COG0747	negative chemotaxis
F1D59_RS10545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1D59_RS10565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F1D59_RS10570	COG0509	glycine decarboxylation via glycine cleavage system
F1D59_RS10575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1D59_RS10580	COG1760	l-serine dehydratase
F1D59_RS10630	COG1376	ErfK ybiS ycfS ynhG family protein
F1D59_RS10650	COG1376	ErfK ybiS ycfS ynhG family protein
F1D59_RS10680	COG0297	glycogen (starch) synthase activity
F1D59_RS10685	COG0489	protein tyrosine kinase activity
F1D59_RS10700	COG0110	maltose O-acetyltransferase activity
F1D59_RS10725	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F1D59_RS10730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1D59_RS10735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F1D59_RS10750	COG0058	SHG alpha-glucan phosphorylase activity
F1D59_RS10755	COG0366	Alpha amylase catalytic
F1D59_RS10775	COG3118	belongs to the thioredoxin family
F1D59_RS10790	COG0205	6-phosphofructokinase activity
F1D59_RS10795	COG0857	belongs to the CobB CobQ family
F1D59_RS10795	COG0280	phosphate acetyltransferase
F1D59_RS10800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F1D59_RS10835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS10835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS10915	COG1703	isobutyryl-CoA mutase activity
F1D59_RS10920	COG0183	Belongs to the thiolase family
F1D59_RS10940	COG1131	(ABC) transporter
F1D59_RS10975	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F1D59_RS10990	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1D59_RS11010	COG2197	response regulator
F1D59_RS11025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F1D59_RS11030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1D59_RS11035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1D59_RS11040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1D59_RS11045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1D59_RS11050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1D59_RS11055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1D59_RS11075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1D59_RS11080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1D59_RS11090	COG2890	protein-(glutamine-N5) methyltransferase activity
F1D59_RS11095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1D59_RS11100	COG0254	rRNA binding
F1D59_RS11115	COG0083	homoserine kinase activity
F1D59_RS11120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1D59_RS11125	COG0460	homoserine dehydrogenase
F1D59_RS11130	COG0019	diaminopimelate decarboxylase activity
F1D59_RS11180	COG1793	dna ligase
F1D59_RS11185	COG3285	dna ligase
F1D59_RS11185	COG1793	dna ligase
F1D59_RS11190	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F1D59_RS11210	COG2205	protein histidine kinase activity
F1D59_RS11220	COG1309	transcriptional regulator
F1D59_RS11235	COG0768	penicillin binding
F1D59_RS11255	COG3103	Sh3 type 3 domain protein
F1D59_RS11255	COG1388	LysM domain
F1D59_RS11255	COG0791	NLP P60 protein
F1D59_RS11280	COG5002	protein histidine kinase activity
F1D59_RS11295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F1D59_RS11310	COG2897	thiosulfate sulfurtransferase activity
F1D59_RS11335	COG0745	RESPONSE REGULATOR receiver
F1D59_RS11340	COG2205	protein histidine kinase activity
F1D59_RS11345	COG0567	Dehydrogenase, E1 component
F1D59_RS11345	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1D59_RS11450	COG4106	trans-aconitate 2-methyltransferase activity
F1D59_RS11455	COG1126	abc transporter atp-binding protein
F1D59_RS11460	COG0765	amino acid transport
F1D59_RS11470	COG0281	malic enzyme
F1D59_RS11475	COG0604	alcohol dehydrogenase
F1D59_RS11510	COG5640	endopeptidase activity
F1D59_RS11530	COG0142	geranyltranstransferase activity
F1D59_RS11535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1D59_RS11540	COG1959	2 iron, 2 sulfur cluster binding
F1D59_RS11545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1D59_RS11545	COG1017	nitric oxide dioxygenase activity
F1D59_RS11620	COG1309	transcriptional regulator
F1D59_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS11635	COG0363	glucosamine-6-phosphate deaminase activity
F1D59_RS11640	COG1472	Belongs to the glycosyl hydrolase 3 family
F1D59_RS11645	COG0395	ABC-type sugar transport system, permease component
F1D59_RS11650	COG1175	transmembrane transport
F1D59_RS11655	COG2182	Extracellular solute-binding protein
F1D59_RS11660	COG2188	Transcriptional regulator
F1D59_RS11665	COG1966	Carbon starvation protein
F1D59_RS11705	COG0242	peptide deformylase activity
F1D59_RS11720	COG2199	diguanylate cyclase activity
F1D59_RS11720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F1D59_RS11725	COG5662	AntiSigma factor
F1D59_RS11730	COG1595	DNA-templated transcription, initiation
F1D59_RS11740	COG2135	peptidase activity
F1D59_RS11750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F1D59_RS11755	COG1162	GTPase activity
F1D59_RS11760	COG2076	Multidrug Resistance protein
F1D59_RS11770	COG0483	inositol monophosphate 1-phosphatase activity
F1D59_RS11780	COG0753	catalase activity
F1D59_RS11805	COG1615	UPF0182 protein
F1D59_RS11815	COG3480	Lon protease (S16) C-terminal proteolytic domain
F1D59_RS11870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F1D59_RS11910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1D59_RS12030	COG0513	Belongs to the DEAD box helicase family
F1D59_RS12045	COG2095	MarC family integral membrane protein
F1D59_RS12065	COG0598	Magnesium transport protein CorA
F1D59_RS12100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1D59_RS12105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1D59_RS12115	COG1595	DNA-templated transcription, initiation
F1D59_RS12135	COG1024	Enoyl-CoA hydratase
F1D59_RS12140	COG0519	Catalyzes the synthesis of GMP from XMP
F1D59_RS12150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1D59_RS12155	COG1611	Belongs to the LOG family
F1D59_RS12160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1D59_RS12195	COG2197	response regulator
F1D59_RS12200	COG4585	Histidine kinase
F1D59_RS12210	COG1131	(ABC) transporter
F1D59_RS12225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1D59_RS12235	COG4608	Belongs to the ABC transporter superfamily
F1D59_RS12245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1D59_RS12250	COG0601	transmembrane transport
F1D59_RS12255	COG4166	transmembrane transport
F1D59_RS12275	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F1D59_RS12300	COG4608	Belongs to the ABC transporter superfamily
F1D59_RS12310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1D59_RS12315	COG0601	transmembrane transport
F1D59_RS12320	COG4166	transmembrane transport
F1D59_RS12325	COG1217	gtp-binding protein TYPA
F1D59_RS12350	COG1053	succinate dehydrogenase
F1D59_RS12365	COG1842	Phage shock protein A
F1D59_RS12395	COG3415	Transposase
F1D59_RS12395	COG2801	Transposase and inactivated derivatives
F1D59_RS12425	COG0697	spore germination
F1D59_RS12510	COG4115	mRNA cleavage
F1D59_RS12515	COG2161	toxin-antitoxin pair type II binding
F1D59_RS12520	COG0012	GTP binding
F1D59_RS12535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F1D59_RS12540	COG1113	amino acid transport
F1D59_RS12545	COG1570	exodeoxyribonuclease VII activity
F1D59_RS12550	COG1722	exodeoxyribonuclease VII activity
F1D59_RS12555	COG0778	Nitroreductase
F1D59_RS12585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F1D59_RS12585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F1D59_RS12620	COG0114	fumarate hydratase activity
F1D59_RS12635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1D59_RS12655	COG1136	(ABC) transporter
F1D59_RS12670	COG0450	alkyl hydroperoxide reductase
F1D59_RS12675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F1D59_RS12700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F1D59_RS12705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1D59_RS12710	COG0667	Aldo Keto reductase
F1D59_RS12770	COG2267	carboxylic ester hydrolase activity
F1D59_RS12800	COG2885	chlorophyll binding
F1D59_RS12820	COG2197	response regulator
F1D59_RS12850	COG2894	cell division
F1D59_RS12880	COG1414	Transcriptional regulator
F1D59_RS12890	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F1D59_RS12935	COG2154	pterin-4-alpha-carbinolamine dehydratase
F1D59_RS12980	COG3853	Toxic anion resistance protein (TelA)
F1D59_RS12995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F1D59_RS13010	COG0463	Glycosyl transferase, family 2
F1D59_RS13025	COG1331	Highly conserved protein containing a thioredoxin domain
F1D59_RS13045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1D59_RS13055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1D59_RS13070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F1D59_RS13080	COG1595	DNA-templated transcription, initiation
F1D59_RS13100	COG0501	Belongs to the peptidase M48B family
F1D59_RS13110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1D59_RS13115	COG3903	Transcriptional regulator
F1D59_RS13115	COG3629	intracellular signal transduction
F1D59_RS13125	COG1064	alcohol dehydrogenase
F1D59_RS13140	COG1376	ErfK ybiS ycfS ynhG family protein
F1D59_RS13155	COG2986	histidine ammonia-lyase
F1D59_RS13165	COG1024	Enoyl-CoA hydratase
F1D59_RS13180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1D59_RS13190	COG0424	maF-like protein
F1D59_RS13215	COG1819	glycosyl
F1D59_RS13225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS13245	COG0515	serine threonine protein kinase
F1D59_RS13250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS13260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS13305	COG4770	biotin carboxylase activity
F1D59_RS13330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1D59_RS13340	COG2205	protein histidine kinase activity
F1D59_RS13345	COG0745	RESPONSE REGULATOR receiver
F1D59_RS13350	COG1595	DNA-templated transcription, initiation
F1D59_RS13365	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS13370	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS13415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F1D59_RS13440	COG0583	DNA-binding transcription factor activity
F1D59_RS13490	COG1079	Belongs to the binding-protein-dependent transport system permease family
F1D59_RS13500	COG3845	ABC transporter
F1D59_RS13505	COG1744	ABC transporter substrate-binding protein PnrA-like
F1D59_RS13510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1D59_RS13510	COG1473	amidohydrolase
F1D59_RS13520	COG2089	acid synthase
F1D59_RS13530	COG1216	Glycosyl transferase, family 2
F1D59_RS13545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS13545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS13560	COG1595	DNA-templated transcription, initiation
F1D59_RS13570	COG2009	succinate dehydrogenase
F1D59_RS13580	COG1053	succinate dehydrogenase
F1D59_RS13585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F1D59_RS13615	COG1309	transcriptional regulator
F1D59_RS13625	COG1408	metallophosphoesterase
F1D59_RS13635	COG1686	Belongs to the peptidase S11 family
F1D59_RS13640	COG1295	ribonuclease BN
F1D59_RS13650	COG0180	Tryptophanyl-tRNA synthetase
F1D59_RS13655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1D59_RS13660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1D59_RS13665	COG0754	glutathionylspermidine amidase activity
F1D59_RS13680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1D59_RS13685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F1D59_RS13705	COG0039	L-malate dehydrogenase activity
F1D59_RS13715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F1D59_RS13725	COG0138	bifunctional purine biosynthesis protein purh
F1D59_RS13755	COG0045	succinate-CoA ligase (ADP-forming) activity
F1D59_RS13760	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F1D59_RS13765	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F1D59_RS13770	COG0714	Associated with various cellular activities
F1D59_RS13785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS13785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F1D59_RS13805	COG0640	Transcriptional regulator
F1D59_RS13825	COG2197	response regulator
F1D59_RS13860	COG0519	Catalyzes the synthesis of GMP from XMP
F1D59_RS13860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F1D59_RS13880	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS13885	COG0515	serine threonine protein kinase
F1D59_RS13895	COG0515	serine threonine protein kinase
F1D59_RS13900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F1D59_RS13915	COG2337	Toxic component of a toxin-antitoxin (TA) module
F1D59_RS13920	COG0516	GMP reductase activity
F1D59_RS13930	COG1595	DNA-templated transcription, initiation
F1D59_RS13945	COG0583	DNA-binding transcription factor activity
F1D59_RS13955	COG4221	oxidoreductase activity
F1D59_RS13965	COG0459	protein refolding
F1D59_RS13970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1D59_RS13975	COG0745	RESPONSE REGULATOR receiver
F1D59_RS13980	COG2205	protein histidine kinase activity
F1D59_RS13985	COG1316	TRANSCRIPTIONal
F1D59_RS14010	COG0726	polysaccharide deacetylase
F1D59_RS14015	COG0726	polysaccharide deacetylase
F1D59_RS14030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1D59_RS14040	COG1214	PFAM Peptidase M22, glycoprotease
F1D59_RS14040	COG0456	acetyltransferase
F1D59_RS14055	COG0802	atpase or kinase
F1D59_RS14065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F1D59_RS14075	COG0736	holo-[acyl-carrier-protein] synthase activity
F1D59_RS14080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1D59_RS14090	COG1072	(Pantothenic acid kinase))
F1D59_RS14100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1D59_RS14105	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F1D59_RS14110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F1D59_RS14120	COG0488	(ABC) transporter
F1D59_RS14125	COG0101	tRNA pseudouridine synthase activity
F1D59_RS14130	COG0203	ribosomal protein L17
F1D59_RS14135	COG0202	RNA polymerase activity
F1D59_RS14140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F1D59_RS14145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F1D59_RS14150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F1D59_RS14155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F1D59_RS14165	COG0563	adenylate kinase activity
F1D59_RS14170	COG0201	protein transport
F1D59_RS14175	COG0200	Binds to the 23S rRNA
F1D59_RS14180	COG1841	ribosomal large subunit assembly
F1D59_RS14185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F1D59_RS14190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F1D59_RS14195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F1D59_RS14200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F1D59_RS14205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1D59_RS14210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1D59_RS14215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F1D59_RS14220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F1D59_RS14225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F1D59_RS14230	COG0255	Belongs to the universal ribosomal protein uL29 family
F1D59_RS14235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F1D59_RS14240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F1D59_RS14245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F1D59_RS14250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F1D59_RS14255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1D59_RS14260	COG0089	rRNA binding
F1D59_RS14265	COG0088	Forms part of the polypeptide exit tunnel
F1D59_RS14270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F1D59_RS14275	COG0051	transcription antitermination factor activity, RNA binding
F1D59_RS14305	COG1215	transferase activity, transferring glycosyl groups
F1D59_RS14335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1D59_RS14340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1D59_RS14345	COG0049	tRNA binding
F1D59_RS14350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F1D59_RS14360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F1D59_RS14365	COG0085	RNA polymerase activity
F1D59_RS14370	COG0222	ribosome binding
F1D59_RS14375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F1D59_RS14390	COG0081	regulation of translation
F1D59_RS14395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F1D59_RS14405	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1D59_RS14415	COG0436	Aminotransferase
F1D59_RS14420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F1D59_RS14430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F1D59_RS14440	COG0477	Major facilitator Superfamily
F1D59_RS14455	COG2030	dehydratase
F1D59_RS14460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1D59_RS14495	COG1666	GTP binding
F1D59_RS14515	COG3304	Inner membrane component domain
F1D59_RS14520	COG0501	Belongs to the peptidase M48B family
F1D59_RS14525	COG1007	ATP synthesis coupled electron transport
F1D59_RS14535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1D59_RS14540	COG0713	ATP synthesis coupled electron transport
F1D59_RS14545	COG0839	Belongs to the complex I subunit 6 family
F1D59_RS14550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS14555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F1D59_RS14560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS14565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS14570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS14590	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1D59_RS14590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F1D59_RS14595	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1D59_RS14600	COG0702	epimerase
F1D59_RS14630	COG0142	geranyltranstransferase activity
F1D59_RS14635	COG3104	oligopeptide transport
F1D59_RS14640	COG2936	dipeptidyl-peptidase activity
F1D59_RS14645	COG0561	phosphatase activity
F1D59_RS14665	COG1007	ATP synthesis coupled electron transport
F1D59_RS14675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1D59_RS14680	COG0713	ATP synthesis coupled electron transport
F1D59_RS14685	COG0839	Belongs to the complex I subunit 6 family
F1D59_RS14690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS14695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F1D59_RS14700	COG1034	ATP synthesis coupled electron transport
F1D59_RS14705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F1D59_RS14715	COG0649	NAD binding
F1D59_RS14720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS14725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS14755	COG2066	Belongs to the glutaminase family
F1D59_RS14760	COG2226	methyltransferase
F1D59_RS14765	COG1136	(ABC) transporter
F1D59_RS14765	COG0577	efflux transmembrane transporter activity
F1D59_RS14770	COG1136	(ABC) transporter
F1D59_RS14810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1D59_RS14820	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F1D59_RS14825	COG1278	Cold shock
F1D59_RS14850	COG2801	Transposase and inactivated derivatives
F1D59_RS14865	COG2188	Transcriptional regulator
F1D59_RS14885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1D59_RS14925	COG1301	dicarboxylic acid transport
F1D59_RS14940	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1D59_RS14950	COG0163	prenyltransferase activity
F1D59_RS14955	COG0705	Rhomboid family
F1D59_RS14965	COG0109	protoheme IX farnesyltransferase activity
F1D59_RS14975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F1D59_RS14990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F1D59_RS15000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F1D59_RS15005	COG1333	cytochrome c biogenesis protein
F1D59_RS15010	COG0785	Cytochrome C biogenesis protein
F1D59_RS15025	COG0406	alpha-ribazole phosphatase activity
F1D59_RS15030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1D59_RS15085	COG2197	response regulator
F1D59_RS15090	COG4946	Tricorn protease homolog
F1D59_RS15090	COG0793	Belongs to the peptidase S41A family
F1D59_RS15100	COG0464	growth
F1D59_RS15180	COG1733	regulation of RNA biosynthetic process
F1D59_RS15195	COG1742	UPF0060 membrane protein
F1D59_RS15205	COG0726	polysaccharide deacetylase
F1D59_RS15215	COG1690	Belongs to the RtcB family
F1D59_RS15235	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F1D59_RS15240	COG0018	arginyl-trna synthetase
F1D59_RS15290	COG0113	porphobilinogen synthase activity
F1D59_RS15320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F1D59_RS15320	COG1648	precorrin-2 dehydrogenase activity
F1D59_RS15325	COG0181	hydroxymethylbilane synthase activity
F1D59_RS15330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1D59_RS15335	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F1D59_RS15385	COG0123	including yeast histone deacetylase and acetoin utilization protein
F1D59_RS15395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1D59_RS15415	COG0180	Tryptophanyl-tRNA synthetase
F1D59_RS15420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F1D59_RS15430	COG0842	Transport permease protein
F1D59_RS15430	COG1129	ABC transporter
F1D59_RS15440	COG4991	sh3 domain protein
F1D59_RS15450	COG0129	dihydroxy-acid dehydratase activity
F1D59_RS15460	COG1082	Xylose isomerase domain protein TIM barrel
F1D59_RS15495	COG0248	Ppx GppA phosphatase
F1D59_RS15515	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F1D59_RS15535	COG1595	DNA-templated transcription, initiation
F1D59_RS15545	COG0745	RESPONSE REGULATOR receiver
F1D59_RS15550	COG2205	protein histidine kinase activity
F1D59_RS15560	COG0739	heme binding
F1D59_RS15585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F1D59_RS15610	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F1D59_RS15620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F1D59_RS15625	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F1D59_RS15635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F1D59_RS15645	COG0640	Transcriptional regulator
F1D59_RS15690	COG0649	NAD binding
F1D59_RS15710	COG1732	Glycine betaine
F1D59_RS15720	COG1174	glycine betaine transport
F1D59_RS15735	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F1D59_RS15735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1D59_RS15750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F1D59_RS15755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F1D59_RS15765	COG0302	gtp cyclohydrolase
F1D59_RS15775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F1D59_RS15780	COG0037	tRNA processing
F1D59_RS15790	COG2027	D-alanyl-D-alanine carboxypeptidase
F1D59_RS15795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F1D59_RS15805	COG0586	Pfam SNARE associated Golgi protein
F1D59_RS15810	COG0789	Transcriptional regulator
F1D59_RS15830	COG2318	DinB family
F1D59_RS15835	COG0768	penicillin binding
F1D59_RS15840	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS15865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1D59_RS15870	COG2801	Transposase and inactivated derivatives
F1D59_RS15870	COG3415	Transposase
F1D59_RS15880	COG1733	regulation of RNA biosynthetic process
F1D59_RS15890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1D59_RS15890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1D59_RS15930	COG1674	ftsk spoiiie
F1D59_RS15990	COG3903	Transcriptional regulator
F1D59_RS15990	COG3629	intracellular signal transduction
F1D59_RS15995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F1D59_RS16005	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F1D59_RS16175	COG0470	DNA polymerase III
F1D59_RS16180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F1D59_RS16185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1D59_RS16185	COG1754	DNA topoisomerase type I activity
F1D59_RS16190	COG2890	protein-(glutamine-N5) methyltransferase activity
F1D59_RS16200	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F1D59_RS16210	COG1366	Belongs to the anti-sigma-factor antagonist family
F1D59_RS16215	COG1111	helicase
F1D59_RS16215	COG1205	dead DEAH box helicase
F1D59_RS16280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1D59_RS16285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F1D59_RS16295	COG2267	carboxylic ester hydrolase activity
F1D59_RS16330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1D59_RS16355	COG0003	Pfam Anion-transporting ATPase
F1D59_RS16365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1D59_RS16375	COG1408	metallophosphoesterase
F1D59_RS16385	COG0659	secondary active sulfate transmembrane transporter activity
F1D59_RS16395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1D59_RS16410	COG1309	transcriptional regulator
F1D59_RS16495	COG1609	Transcriptional regulator
F1D59_RS16550	COG2850	peptidyl-arginine hydroxylation
F1D59_RS16600	COG1595	DNA-templated transcription, initiation
F1D59_RS16605	COG1252	NADH dehydrogenase
F1D59_RS16655	COG0402	S-adenosylhomocysteine deaminase activity
F1D59_RS16680	COG1595	DNA-templated transcription, initiation
F1D59_RS16700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F1D59_RS16705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F1D59_RS16725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F1D59_RS16730	COG0693	protein deglycase activity
F1D59_RS16765	COG4585	Histidine kinase
F1D59_RS16770	COG2197	response regulator
F1D59_RS16780	COG2197	response regulator
F1D59_RS16790	COG3559	Exporter of polyketide antibiotics
F1D59_RS16795	COG1131	(ABC) transporter
F1D59_RS16820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F1D59_RS16860	COG3844	kynureninase activity
F1D59_RS16875	COG0191	fructose-bisphosphate aldolase activity
F1D59_RS16880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F1D59_RS16895	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F1D59_RS16920	COG0542	response to heat
F1D59_RS16945	COG0789	Transcriptional regulator
F1D59_RS16950	COG0484	heat shock protein binding
F1D59_RS16955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1D59_RS16960	COG0443	Heat shock 70 kDa protein
F1D59_RS16970	COG0247	lactate metabolic process
F1D59_RS16970	COG2181	nitrate reductase activity
F1D59_RS16990	COG0717	Belongs to the dCTP deaminase family
F1D59_RS17000	COG1278	Cold shock
F1D59_RS17005	COG0513	Belongs to the DEAD box helicase family
F1D59_RS17025	COG3226	Transcriptional regulator
F1D59_RS17030	COG0596	Alpha beta hydrolase
F1D59_RS17040	COG1595	DNA-templated transcription, initiation
F1D59_RS17055	COG4585	Histidine kinase
F1D59_RS17060	COG2197	response regulator
F1D59_RS17065	COG0577	efflux transmembrane transporter activity
F1D59_RS17065	COG1136	(ABC) transporter
F1D59_RS17070	COG0577	efflux transmembrane transporter activity
F1D59_RS17070	COG1136	(ABC) transporter
F1D59_RS17090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1D59_RS17115	COG1278	Cold shock
F1D59_RS17200	COG1289	transmembrane transporter activity
F1D59_RS17210	COG2205	protein histidine kinase activity
F1D59_RS17225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F1D59_RS17255	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS17270	COG1362	aminopeptidase activity
F1D59_RS17320	COG2271	Major facilitator Superfamily
F1D59_RS17370	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1D59_RS17375	COG0022	dehydrogenase e1 component
F1D59_RS17395	COG0515	serine threonine protein kinase
F1D59_RS17400	COG0515	serine threonine protein kinase
F1D59_RS17415	COG4591	ABC-type transport system involved in lipoprotein release permease component
F1D59_RS17415	COG1136	(ABC) transporter
F1D59_RS17440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F1D59_RS17465	COG1522	sequence-specific DNA binding
F1D59_RS17470	COG1309	transcriptional regulator
F1D59_RS17505	COG3396	Phenylacetate-CoA oxygenase
F1D59_RS17510	COG3460	Phenylacetate-CoA oxygenase
F1D59_RS17515	COG3396	Phenylacetate-CoA oxygenase
F1D59_RS17520	COG2151	metal-sulfur cluster biosynthetic enzyme
F1D59_RS17525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1D59_RS17550	COG2197	response regulator
F1D59_RS17555	COG4585	Histidine kinase
F1D59_RS17565	COG1716	ATPase activity
F1D59_RS17570	COG1716	ATPase activity
F1D59_RS17590	COG0515	serine threonine protein kinase
F1D59_RS17595	COG3764	Sortase (surface protein transpeptidase)
F1D59_RS17600	COG3764	Sortase (surface protein transpeptidase)
F1D59_RS17615	COG3764	Sortase (surface protein transpeptidase)
F1D59_RS17630	COG0457	Tetratricopeptide repeat
F1D59_RS17630	COG0705	Rhomboid family
F1D59_RS17660	COG3629	intracellular signal transduction
F1D59_RS17660	COG3903	Transcriptional regulator
F1D59_RS17665	COG3903	Transcriptional regulator
F1D59_RS17665	COG3629	intracellular signal transduction
F1D59_RS17675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1D59_RS17690	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS17690	COG3321	synthase
F1D59_RS17690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS17690	COG0300	oxidoreductase activity
F1D59_RS17690	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS17695	COG0640	Transcriptional regulator
F1D59_RS17735	COG0515	serine threonine protein kinase
F1D59_RS17760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1D59_RS17770	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F1D59_RS17775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F1D59_RS17780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F1D59_RS17785	COG0592	DNA-directed DNA polymerase activity
F1D59_RS17790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1D59_RS17800	COG0594	ribonuclease P activity
F1D59_RS17805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F1D59_RS17810	COG0706	membrane insertase activity
F1D59_RS17820	COG0357	Ribosomal RNA small subunit methyltransferase G
F1D59_RS17825	COG1192	Involved in chromosome partitioning
F1D59_RS17840	COG3118	belongs to the thioredoxin family
F1D59_RS17845	COG0492	ferredoxin-NADP+ reductase activity
F1D59_RS17855	COG1595	DNA-templated transcription, initiation
F1D59_RS17875	COG0617	tRNA 3'-terminal CCA addition
F1D59_RS17895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1D59_RS17920	COG0360	Binds together with S18 to 16S ribosomal RNA
F1D59_RS17925	COG0629	single-stranded DNA binding
F1D59_RS17930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1D59_RS17935	COG0359	binds to the 23S rRNA
F1D59_RS17945	COG0305	Participates in initiation and elongation during chromosome replication
F1D59_RS17960	COG0456	acetyltransferase
F1D59_RS17990	COG0626	cystathionine gamma-synthase activity
F1D59_RS17995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1D59_RS18000	COG1950	PFAM Membrane protein of
F1D59_RS18005	COG0662	Cupin 2, conserved barrel domain protein
F1D59_RS18030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F1D59_RS18060	COG1609	Transcriptional regulator
F1D59_RS18065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1D59_RS18075	COG1271	oxidase subunit
F1D59_RS18080	COG1294	oxidase, subunit
F1D59_RS18085	COG4988	ABC transporter
F1D59_RS18095	COG0561	phosphatase activity
F1D59_RS18105	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F1D59_RS18115	COG0789	Transcriptional regulator
F1D59_RS18130	COG1131	(ABC) transporter
F1D59_RS18155	COG2197	response regulator
F1D59_RS18170	COG0561	phosphatase activity
F1D59_RS18175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F1D59_RS18185	COG2837	iron assimilation
F1D59_RS18190	COG2372	response to copper ion
F1D59_RS18200	COG1999	signal sequence binding
F1D59_RS18220	COG0006	proline dipeptidase activity
F1D59_RS18240	COG0653	protein targeting
F1D59_RS18255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1D59_RS18270	COG2855	membrane
F1D59_RS18300	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS18310	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS18325	COG1595	DNA-templated transcription, initiation
F1D59_RS18330	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS18390	COG0745	RESPONSE REGULATOR receiver
F1D59_RS18395	COG2205	protein histidine kinase activity
F1D59_RS18420	COG1846	Transcriptional regulator
F1D59_RS18435	COG1191	sigma factor activity
F1D59_RS18480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F1D59_RS18495	COG0433	COG0433 Predicted ATPase
F1D59_RS18545	COG0151	Belongs to the GarS family
F1D59_RS18560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F1D59_RS18570	COG2197	response regulator
F1D59_RS18575	COG3850	Histidine kinase
F1D59_RS18585	COG1131	(ABC) transporter
F1D59_RS18605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1D59_RS18610	COG0047	phosphoribosylformylglycinamidine synthase activity
F1D59_RS18615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1D59_RS18635	COG3119	arylsulfatase activity
F1D59_RS18645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F1D59_RS18675	COG1643	Atp-dependent helicase
F1D59_RS18690	COG0785	Cytochrome C biogenesis protein
F1D59_RS18715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1D59_RS18720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1D59_RS18730	COG0513	Belongs to the DEAD box helicase family
F1D59_RS18765	COG1196	nuclear chromosome segregation
F1D59_RS18765	COG0739	heme binding
F1D59_RS18765	COG0741	lytic transglycosylase activity
F1D59_RS18775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1D59_RS18780	COG0579	oxidoreductase
F1D59_RS18820	COG1252	NADH dehydrogenase
F1D59_RS18870	COG2226	methyltransferase
F1D59_RS18955	COG1357	PFAM Pentapeptide repeats (8 copies)
F1D59_RS18965	COG1280	lysine exporter protein (LysE YggA)
F1D59_RS18980	COG0739	heme binding
F1D59_RS18980	COG1196	nuclear chromosome segregation
F1D59_RS18980	COG0741	lytic transglycosylase activity
F1D59_RS18985	COG0671	phosphoesterase, PA-phosphatase related
F1D59_RS19010	COG1937	Protein conserved in bacteria
F1D59_RS19020	COG0306	phosphate transporter
F1D59_RS19055	COG0456	acetyltransferase
F1D59_RS19060	COG0737	Belongs to the 5'-nucleotidase family
F1D59_RS19065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1D59_RS19075	COG0823	Involved in the tonB-independent uptake of proteins
F1D59_RS19090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1D59_RS19100	COG1609	Transcriptional regulator
F1D59_RS19105	COG0745	RESPONSE REGULATOR receiver
F1D59_RS19155	COG3485	protocatechuate 3,4-dioxygenase
F1D59_RS19160	COG0735	belongs to the Fur family
F1D59_RS19170	COG1490	D-aminoacyl-tRNA deacylase activity
F1D59_RS19180	COG4552	Acetyltransferase involved in intracellular survival and related
F1D59_RS19185	COG2890	protein-(glutamine-N5) methyltransferase activity
F1D59_RS19230	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS19250	COG0588	phosphoglycerate mutase activity
F1D59_RS19275	COG5002	protein histidine kinase activity
F1D59_RS19290	COG1329	Transcriptional regulator
F1D59_RS19295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F1D59_RS19300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F1D59_RS19305	COG0215	cysteine-tRNA ligase activity
F1D59_RS19310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1D59_RS19330	COG3842	ATPase activity
F1D59_RS19395	COG3290	protein histidine kinase activity
F1D59_RS19420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1D59_RS19445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F1D59_RS19455	COG2182	Extracellular solute-binding protein
F1D59_RS19465	COG0561	phosphatase activity
F1D59_RS19465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1D59_RS19470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F1D59_RS19475	COG0463	Glycosyl transferase, family 2
F1D59_RS19495	COG0459	protein refolding
F1D59_RS19510	COG0135	phosphoribosylanthranilate isomerase activity
F1D59_RS19525	COG0515	serine threonine protein kinase
F1D59_RS19525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1D59_RS19585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F1D59_RS19620	COG3973	AAA domain
F1D59_RS19640	COG1061	Type III restriction enzyme res subunit
F1D59_RS19680	COG1595	DNA-templated transcription, initiation
F1D59_RS19695	COG1278	Cold shock
F1D59_RS19700	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F1D59_RS19705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F1D59_RS19715	COG2814	Major facilitator Superfamily
F1D59_RS19735	COG0667	Aldo Keto reductase
F1D59_RS19765	COG1196	nuclear chromosome segregation
F1D59_RS19765	COG0741	lytic transglycosylase activity
F1D59_RS19765	COG0739	heme binding
F1D59_RS19790	COG2252	PERMEase
F1D59_RS19800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1D59_RS19840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F1D59_RS19845	COG0247	lactate metabolic process
F1D59_RS19845	COG0277	FAD linked oxidase domain protein
F1D59_RS19880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1D59_RS19915	COG0259	pyridoxamine-phosphate oxidase activity
F1D59_RS19930	COG4821	SIS domain
F1D59_RS19955	COG1131	(ABC) transporter
F1D59_RS20025	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS20035	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS20040	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS20060	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS20065	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS20070	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F1D59_RS20075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1D59_RS20090	COG1024	Enoyl-CoA hydratase
F1D59_RS20105	COG2072	flavoprotein involved in K transport
F1D59_RS20120	COG0259	pyridoxamine-phosphate oxidase activity
F1D59_RS20125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F1D59_RS20130	COG1595	DNA-templated transcription, initiation
F1D59_RS20145	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS20155	COG1309	transcriptional regulator
F1D59_RS20165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1D59_RS20165	COG0515	serine threonine protein kinase
F1D59_RS20180	COG1024	Enoyl-CoA hydratase
F1D59_RS20205	COG2226	methyltransferase
F1D59_RS20255	COG0494	nUDIX hydrolase
F1D59_RS20260	COG0577	efflux transmembrane transporter activity
F1D59_RS20260	COG1136	(ABC) transporter
F1D59_RS20265	COG1136	(ABC) transporter
F1D59_RS20265	COG0577	efflux transmembrane transporter activity
F1D59_RS20280	COG0745	RESPONSE REGULATOR receiver
F1D59_RS20285	COG2205	protein histidine kinase activity
F1D59_RS20330	COG4335	DNA alkylation repair
F1D59_RS20350	COG0346	lactoylglutathione lyase activity
F1D59_RS20405	COG2365	Tyrosine phosphatase family
F1D59_RS20410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1D59_RS20440	COG1597	lipid kinase activity
F1D59_RS20455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1D59_RS20480	COG1686	Belongs to the peptidase S11 family
F1D59_RS20495	COG2205	protein histidine kinase activity
F1D59_RS20525	COG2409	Drug exporters of the RND superfamily
F1D59_RS20540	COG2409	Drug exporters of the RND superfamily
F1D59_RS20545	COG1408	metallophosphoesterase
F1D59_RS20555	COG3903	Transcriptional regulator
F1D59_RS20555	COG3629	intracellular signal transduction
F1D59_RS20560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1D59_RS20590	COG0604	alcohol dehydrogenase
F1D59_RS20590	COG3321	synthase
F1D59_RS20620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS20635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS20640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS20650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS20655	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS20680	COG0477	Major facilitator Superfamily
F1D59_RS20740	COG3384	dioxygenase
F1D59_RS20760	COG0477	Major facilitator Superfamily
F1D59_RS20765	COG1349	DNA-binding transcription factor activity
F1D59_RS20830	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS20835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F1D59_RS20855	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS20880	COG0492	ferredoxin-NADP+ reductase activity
F1D59_RS20925	COG2223	nitrite transmembrane transporter activity
F1D59_RS20935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F1D59_RS20945	COG0243	molybdopterin cofactor binding
F1D59_RS20950	COG0437	4 iron, 4 sulfur cluster binding
F1D59_RS20970	COG1970	mechanosensitive ion channel activity
F1D59_RS20985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F1D59_RS21000	COG3263	regulation of cellular component size
F1D59_RS21010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F1D59_RS21015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F1D59_RS21025	COG0315	cyclic pyranopterin monophosphate synthase activity
F1D59_RS21030	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1D59_RS21030	COG0315	cyclic pyranopterin monophosphate synthase activity
F1D59_RS21050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1D59_RS21060	COG0708	Exodeoxyribonuclease III
F1D59_RS21070	COG2072	flavoprotein involved in K transport
F1D59_RS21075	COG2267	carboxylic ester hydrolase activity
F1D59_RS21080	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS21085	COG0793	Belongs to the peptidase S41A family
F1D59_RS21085	COG4946	Tricorn protease homolog
F1D59_RS21095	COG2409	Drug exporters of the RND superfamily
F1D59_RS21105	COG0310	cobalt ion transport
F1D59_RS21115	COG1122	ATPase activity
F1D59_RS21120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1D59_RS21125	COG0442	prolyl-tRNA aminoacylation
F1D59_RS21180	COG0084	hydrolase, TatD family'
F1D59_RS21185	COG3584	3D domain protein
F1D59_RS21185	COG3583	domain protein
F1D59_RS21190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1D59_RS21195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F1D59_RS21205	COG0488	(ABC) transporter
F1D59_RS21230	COG2197	response regulator
F1D59_RS21235	COG1846	Transcriptional regulator
F1D59_RS21240	COG4106	trans-aconitate 2-methyltransferase activity
F1D59_RS21250	COG1309	transcriptional regulator
F1D59_RS21260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F1D59_RS21265	COG0193	aminoacyl-tRNA hydrolase activity
F1D59_RS21270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F1D59_RS21275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F1D59_RS21280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F1D59_RS21290	COG4585	Histidine kinase
F1D59_RS21320	COG0596	Alpha beta hydrolase
F1D59_RS21335	COG2814	Major facilitator Superfamily
F1D59_RS21340	COG1136	(ABC) transporter
F1D59_RS21345	COG0577	efflux transmembrane transporter activity
F1D59_RS21365	COG2815	serine threonine protein kinase
F1D59_RS21365	COG0515	serine threonine protein kinase
F1D59_RS21385	COG1017	nitric oxide dioxygenase activity
F1D59_RS21385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1D59_RS21390	COG2124	cytochrome p450
F1D59_RS21405	COG0148	phosphopyruvate hydratase activity
F1D59_RS21435	COG1252	NADH dehydrogenase
F1D59_RS21440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1D59_RS21445	COG0577	efflux transmembrane transporter activity
F1D59_RS21450	COG1136	(ABC) transporter
F1D59_RS21480	COG0183	Belongs to the thiolase family
F1D59_RS21485	COG2755	lipolytic protein G-D-S-L family
F1D59_RS21505	COG0019	diaminopimelate decarboxylase activity
F1D59_RS21510	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F1D59_RS21525	COG1228	amidohydrolase
F1D59_RS21550	COG3104	oligopeptide transport
F1D59_RS21555	COG0745	RESPONSE REGULATOR receiver
F1D59_RS21560	COG2205	protein histidine kinase activity
F1D59_RS21590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F1D59_RS21610	COG1316	TRANSCRIPTIONal
F1D59_RS21615	COG1607	acyl-coa hydrolase
F1D59_RS21635	COG1316	TRANSCRIPTIONal
F1D59_RS21640	COG1316	TRANSCRIPTIONal
F1D59_RS21660	COG0778	Nitroreductase
F1D59_RS21660	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F1D59_RS21665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F1D59_RS21700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1D59_RS21705	COG2835	tetraacyldisaccharide 4'-kinase activity
F1D59_RS21715	COG1482	cell wall glycoprotein biosynthetic process
F1D59_RS21725	COG0681	Belongs to the peptidase S26 family
F1D59_RS21730	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F1D59_RS21775	COG0714	Associated with various cellular activities
F1D59_RS21795	COG0745	RESPONSE REGULATOR receiver
F1D59_RS21800	COG5002	protein histidine kinase activity
F1D59_RS21800	COG5000	phosphorelay sensor kinase activity
F1D59_RS21805	COG0823	Involved in the tonB-independent uptake of proteins
F1D59_RS21810	COG1040	competence protein
F1D59_RS21815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F1D59_RS21820	COG2197	response regulator
F1D59_RS21835	COG0653	protein targeting
F1D59_RS21860	COG1134	teichoic acid transport
F1D59_RS21860	COG1388	LysM domain
F1D59_RS21880	COG0395	ABC-type sugar transport system, permease component
F1D59_RS21885	COG1175	transmembrane transport
F1D59_RS21895	COG1674	ftsk spoiiie
F1D59_RS21900	COG0515	serine threonine protein kinase
F1D59_RS21905	COG0515	serine threonine protein kinase
F1D59_RS21910	COG3415	Transposase
F1D59_RS21910	COG2801	Transposase and inactivated derivatives
F1D59_RS21920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F1D59_RS21930	COG2884	Cell division ATP-binding protein ftsE
F1D59_RS21935	COG2177	Part of the ABC transporter FtsEX involved in
F1D59_RS21940	COG0793	Belongs to the peptidase S41A family
F1D59_RS21945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F1D59_RS21975	COG0583	DNA-binding transcription factor activity
F1D59_RS22000	COG3973	AAA domain
F1D59_RS22010	COG0776	regulation of translation
F1D59_RS22015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1D59_RS22020	COG1678	Uncharacterized ACR, COG1678
F1D59_RS22030	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F1D59_RS22040	COG2080	2 iron, 2 sulfur cluster binding
F1D59_RS22060	COG1404	Belongs to the peptidase S8 family
F1D59_RS22090	COG3654	unkown
F1D59_RS22125	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F1D59_RS22130	COG3063	Type IV pilus biogenesis stability protein PilW
F1D59_RS22135	COG0277	FAD linked oxidase domain protein
F1D59_RS22170	COG1335	isochorismatase
F1D59_RS22180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F1D59_RS22190	COG1113	amino acid transport
F1D59_RS22210	COG3189	MarR family transcriptional regulator
F1D59_RS22220	COG1234	tRNA 3'-trailer cleavage
F1D59_RS22225	COG1263	PTS System
F1D59_RS22230	COG1263	PTS System
F1D59_RS22235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F1D59_RS22240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F1D59_RS22250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F1D59_RS22290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1D59_RS22305	COG4555	ABC transporter
F1D59_RS22315	COG2733	membrane
F1D59_RS22350	COG3764	Sortase (surface protein transpeptidase)
F1D59_RS22360	COG0706	membrane insertase activity
F1D59_RS22365	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1D59_RS22370	COG0673	inositol 2-dehydrogenase activity
F1D59_RS22375	COG1846	Transcriptional regulator
F1D59_RS22375	COG1940	carbohydrate kinase activity
F1D59_RS22385	COG2188	Transcriptional regulator
F1D59_RS22390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1D59_RS22455	COG3397	chitin binding
F1D59_RS22460	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS22475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS22550	COG0406	alpha-ribazole phosphatase activity
F1D59_RS22570	COG0583	DNA-binding transcription factor activity
F1D59_RS22580	COG0745	RESPONSE REGULATOR receiver
F1D59_RS22635	COG0395	ABC-type sugar transport system, permease component
F1D59_RS22660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F1D59_RS22665	COG4977	sequence-specific DNA binding
F1D59_RS22675	COG0589	response to stress
F1D59_RS22685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1D59_RS22715	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F1D59_RS22720	COG0076	glutamate decarboxylase activity
F1D59_RS22735	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS22750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1D59_RS22755	COG1309	transcriptional regulator
F1D59_RS22785	COG1946	Acyl-CoA thioesterase
F1D59_RS22805	COG0028	Belongs to the TPP enzyme family
F1D59_RS22835	COG1472	Belongs to the glycosyl hydrolase 3 family
F1D59_RS22845	COG0697	spore germination
F1D59_RS22860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F1D59_RS22885	COG0673	inositol 2-dehydrogenase activity
F1D59_RS22890	COG1082	Xylose isomerase domain protein TIM barrel
F1D59_RS22895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1D59_RS22900	COG3718	enzyme involved in inositol metabolism
F1D59_RS22905	COG3962	Belongs to the TPP enzyme family
F1D59_RS22945	COG0667	Aldo Keto reductase
F1D59_RS22960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1D59_RS22975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F1D59_RS22985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1D59_RS23005	COG0629	single-stranded DNA binding
F1D59_RS23040	COG2346	COG2346, Truncated hemoglobins
F1D59_RS23045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F1D59_RS23065	COG0515	serine threonine protein kinase
F1D59_RS23075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1D59_RS23090	COG1486	melibiose metabolic process
F1D59_RS23095	COG0395	ABC-type sugar transport system, permease component
F1D59_RS23100	COG1175	transmembrane transport
F1D59_RS23115	COG0668	transmembrane transport
F1D59_RS23125	COG3291	Pkd domain containing protein
F1D59_RS23125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F1D59_RS23150	COG0697	spore germination
F1D59_RS23160	COG0583	DNA-binding transcription factor activity
F1D59_RS23180	COG2234	aminopeptidase activity
F1D59_RS23215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F1D59_RS23220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F1D59_RS23225	COG1113	amino acid transport
F1D59_RS23230	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS23235	COG1113	amino acid transport
F1D59_RS23245	COG1113	amino acid transport
F1D59_RS23260	COG4552	Acetyltransferase involved in intracellular survival and related
F1D59_RS23270	COG1136	(ABC) transporter
F1D59_RS23275	COG1660	Displays ATPase and GTPase activities
F1D59_RS23315	COG0544	peptidyl-prolyl cis-trans isomerase activity
F1D59_RS23320	COG0740	serine-type endopeptidase activity
F1D59_RS23325	COG0740	serine-type endopeptidase activity
F1D59_RS23330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1D59_RS23345	COG0525	valine-tRNA ligase activity
F1D59_RS23355	COG4585	Histidine kinase
F1D59_RS23360	COG1077	Cell shape determining protein MreB Mrl
F1D59_RS23365	COG0285	dihydrofolate synthase activity
F1D59_RS23375	COG0105	UTP biosynthetic process
F1D59_RS23380	COG1077	Cell shape determining protein MreB Mrl
F1D59_RS23395	COG0768	penicillin binding
F1D59_RS23400	COG0772	Belongs to the SEDS family
F1D59_RS23425	COG1530	ribonuclease E activity
F1D59_RS23430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F1D59_RS23435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F1D59_RS23440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1D59_RS23445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1D59_RS23445	COG1215	transferase activity, transferring glycosyl groups
F1D59_RS23455	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS23460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1D59_RS23460	COG0463	Glycosyl transferase, family 2
F1D59_RS23465	COG0463	Glycosyl transferase, family 2
F1D59_RS23475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F1D59_RS23485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F1D59_RS23500	COG0501	Belongs to the peptidase M48B family
F1D59_RS23510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F1D59_RS23520	COG0799	negative regulation of ribosome biogenesis
F1D59_RS23525	COG0588	phosphoglycerate mutase activity
F1D59_RS23545	COG0495	leucyl-tRNA aminoacylation
F1D59_RS23555	COG1307	EDD domain protein, DegV family
F1D59_RS23560	COG1596	polysaccharide export
F1D59_RS23560	COG1555	photosystem II stabilization
F1D59_RS23570	COG2353	YceI-like domain
F1D59_RS23585	COG0268	Binds directly to 16S ribosomal RNA
F1D59_RS23590	COG0481	GTPase activity
F1D59_RS23615	COG1420	regulation of RNA biosynthetic process
F1D59_RS23620	COG0484	heat shock protein binding
F1D59_RS23625	COG2070	2-Nitropropane dioxygenase
F1D59_RS23635	COG0537	adenosine 5'-monophosphoramidase activity
F1D59_RS23640	COG1234	tRNA 3'-trailer cleavage
F1D59_RS23645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1D59_RS23645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1D59_RS23655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F1D59_RS23665	COG2315	Protein conserved in bacteria
F1D59_RS23675	COG2271	Major facilitator Superfamily
F1D59_RS23690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F1D59_RS23695	COG2813	Specifically methylates the guanine in position
F1D59_RS23715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1D59_RS23720	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS23730	COG2233	PERMEase
F1D59_RS23735	COG1381	Involved in DNA repair and RecF pathway recombination
F1D59_RS23740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1D59_RS23755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1D59_RS23760	COG1121	(ABC) transporter
F1D59_RS23765	COG3443	Belongs to the bacterial solute-binding protein 9 family
F1D59_RS23765	COG0803	Belongs to the bacterial solute-binding protein 9 family
F1D59_RS23770	COG0423	glycine-tRNA ligase activity
F1D59_RS23780	COG1309	transcriptional regulator
F1D59_RS23785	COG0667	Aldo Keto reductase
F1D59_RS23800	COG0477	Major facilitator Superfamily
F1D59_RS23810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1D59_RS23810	COG0574	Belongs to the PEP-utilizing enzyme family
F1D59_RS23835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1D59_RS23835	COG2146	nitrite reductase [NAD(P)H] activity
F1D59_RS23840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1D59_RS23870	COG0358	DNA primase activity
F1D59_RS23880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F1D59_RS23890	COG2949	membrane
F1D59_RS23905	COG0243	molybdopterin cofactor binding
F1D59_RS23940	COG1070	Carbohydrate kinase
F1D59_RS23965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1D59_RS23975	COG0662	Cupin 2, conserved barrel domain protein
F1D59_RS23990	COG0825	malonyl-CoA metabolic process
F1D59_RS23990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F1D59_RS24000	COG1522	sequence-specific DNA binding
F1D59_RS24010	COG1077	Cell shape determining protein MreB Mrl
F1D59_RS24015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F1D59_RS24035	COG2130	NADP-dependent
F1D59_RS24040	COG1764	response to oxidative stress
F1D59_RS24055	COG1733	regulation of RNA biosynthetic process
F1D59_RS24070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1D59_RS24080	COG2084	Dehydrogenase
F1D59_RS24090	COG1309	transcriptional regulator
F1D59_RS24110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS24115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS24120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1D59_RS24145	COG0789	Transcriptional regulator
F1D59_RS24150	COG0667	Aldo Keto reductase
F1D59_RS24165	COG1725	Transcriptional regulator
F1D59_RS24180	COG1309	transcriptional regulator
F1D59_RS24190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1D59_RS24195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F1D59_RS24240	COG1358	cellular component organization or biogenesis
F1D59_RS24330	COG2318	DinB family
F1D59_RS24385	COG2124	cytochrome p450
F1D59_RS24390	COG0183	Belongs to the thiolase family
F1D59_RS24405	COG3845	ABC transporter
F1D59_RS24420	COG1657	PFAM Prenyltransferase squalene oxidase
F1D59_RS24450	COG1309	transcriptional regulator
F1D59_RS24455	COG0297	glycogen (starch) synthase activity
F1D59_RS24490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS24505	COG0860	N-Acetylmuramoyl-L-alanine amidase
F1D59_RS24535	COG0515	serine threonine protein kinase
F1D59_RS24535	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1D59_RS24545	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS24550	COG0183	Belongs to the thiolase family
F1D59_RS24560	COG1595	DNA-templated transcription, initiation
F1D59_RS24565	COG2197	response regulator
F1D59_RS24570	COG2030	dehydratase
F1D59_RS24580	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS24590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F1D59_RS24620	COG3022	response to hydroperoxide
F1D59_RS24635	COG1834	amidinotransferase
F1D59_RS24645	COG2814	Major facilitator Superfamily
F1D59_RS24655	COG0384	phenazine biosynthesis protein PhzF
F1D59_RS24665	COG0672	)-iron permease
F1D59_RS24670	COG2837	iron assimilation
F1D59_RS24680	COG1120	ATPase activity
F1D59_RS24685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1D59_RS24690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1D59_RS24715	COG5398	heme oxygenase
F1D59_RS24750	COG1994	Peptidase M50
F1D59_RS24770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F1D59_RS24780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1D59_RS24780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1D59_RS24790	COG2132	Multicopper oxidase
F1D59_RS24830	COG0174	glutamine synthetase
F1D59_RS24855	COG0464	growth
F1D59_RS24895	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F1D59_RS24900	COG2340	Cysteine-rich secretory protein family
F1D59_RS24960	COG3511	phospholipase C
F1D59_RS24975	COG1609	Transcriptional regulator
F1D59_RS24995	COG1175	transmembrane transport
F1D59_RS25000	COG3833	ABC-type maltose transport systems, permease component
F1D59_RS25005	COG0366	Alpha amylase catalytic
F1D59_RS25060	COG2365	Tyrosine phosphatase family
F1D59_RS25080	COG0745	RESPONSE REGULATOR receiver
F1D59_RS25105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1D59_RS25110	COG1846	Transcriptional regulator
F1D59_RS25120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1D59_RS25165	COG0321	lipoyl(octanoyl) transferase activity
F1D59_RS25170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F1D59_RS25205	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS25215	COG2815	serine threonine protein kinase
F1D59_RS25215	COG0515	serine threonine protein kinase
F1D59_RS25220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F1D59_RS25230	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1D59_RS25235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1D59_RS25240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F1D59_RS25250	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS25280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1D59_RS25280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F1D59_RS25285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F1D59_RS25300	COG2226	methyltransferase
F1D59_RS25325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F1D59_RS25330	COG2197	response regulator
F1D59_RS25335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1D59_RS25340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F1D59_RS25360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1D59_RS25365	COG1104	cysteine desulfurase activity
F1D59_RS25370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1D59_RS25375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1D59_RS25385	COG1376	ErfK ybiS ycfS ynhG family protein
F1D59_RS25395	COG1845	cytochrome c oxidase, subunit III
F1D59_RS25400	COG2010	Cytochrome c
F1D59_RS25405	COG0723	plastoquinol--plastocyanin reductase activity
F1D59_RS25410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F1D59_RS25415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1D59_RS25420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1D59_RS25450	COG0791	NLP P60 protein
F1D59_RS25465	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS25490	COG0003	Pfam Anion-transporting ATPase
F1D59_RS25500	COG1940	carbohydrate kinase activity
F1D59_RS25525	COG4585	Histidine kinase
F1D59_RS25530	COG2197	response regulator
F1D59_RS25535	COG0205	6-phosphofructokinase activity
F1D59_RS25540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1D59_RS25555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F1D59_RS25565	COG2193	ferroxidase activity
F1D59_RS25570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F1D59_RS25580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F1D59_RS25585	COG2815	serine threonine protein kinase
F1D59_RS25585	COG0515	serine threonine protein kinase
F1D59_RS25590	COG2022	thiamine diphosphate biosynthetic process
F1D59_RS25600	COG2022	thiamine diphosphate biosynthetic process
F1D59_RS25600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1D59_RS25615	COG0352	thiamine-phosphate diphosphorylase activity
F1D59_RS25630	COG1233	COG1233 Phytoene dehydrogenase and related
F1D59_RS25655	COG1131	(ABC) transporter
F1D59_RS25665	COG1309	transcriptional regulator
F1D59_RS25680	COG0714	Associated with various cellular activities
F1D59_RS25690	COG0275	rRNA processing
F1D59_RS25705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F1D59_RS25715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1D59_RS25720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1D59_RS25730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1D59_RS25735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F1D59_RS25755	COG1799	cell septum assembly
F1D59_RS25770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F1D59_RS25780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1D59_RS25810	COG0668	transmembrane transport
F1D59_RS25840	COG2801	Transposase and inactivated derivatives
F1D59_RS25840	COG3415	Transposase
F1D59_RS25850	COG0587	DNA-directed DNA polymerase activity
F1D59_RS25880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F1D59_RS25895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F1D59_RS25900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1D59_RS25905	COG0131	Imidazoleglycerol-phosphate dehydratase
F1D59_RS25915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F1D59_RS25920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F1D59_RS25925	COG0251	oxidation-reduction process
F1D59_RS25930	COG0107	imidazoleglycerol-phosphate synthase activity
F1D59_RS25940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F1D59_RS25965	COG0134	indole-3-glycerol-phosphate synthase activity
F1D59_RS25970	COG0133	tryptophan synthase activity
F1D59_RS25975	COG0159	tryptophan synthase activity
F1D59_RS25985	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1D59_RS25995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1D59_RS26000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1D59_RS26030	COG0069	glutamate synthase activity
F1D59_RS26030	COG0070	glutamate synthase
F1D59_RS26030	COG0067	glutamate synthase
F1D59_RS26055	COG1725	Transcriptional regulator
F1D59_RS26060	COG1131	(ABC) transporter
F1D59_RS26075	COG2304	oxidoreductase activity
F1D59_RS26115	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS26120	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS26130	COG1309	transcriptional regulator
F1D59_RS26135	COG0183	Belongs to the thiolase family
F1D59_RS26140	COG1278	Cold shock
F1D59_RS26145	COG0513	Belongs to the DEAD box helicase family
F1D59_RS26150	COG2365	Tyrosine phosphatase family
F1D59_RS26170	COG1024	Enoyl-CoA hydratase
F1D59_RS26180	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS26200	COG2197	response regulator
F1D59_RS26210	COG0287	Prephenate dehydrogenase
F1D59_RS26210	COG1605	Chorismate mutase
F1D59_RS26235	COG0737	Belongs to the 5'-nucleotidase family
F1D59_RS26325	COG2050	protein possibly involved in aromatic compounds catabolism
F1D59_RS26360	COG1643	Atp-dependent helicase
F1D59_RS26365	COG2226	methyltransferase
F1D59_RS26380	COG0237	dephospho-CoA kinase activity
F1D59_RS26405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1D59_RS26410	COG4279	zinc finger
F1D59_RS26450	COG2313	pseudouridylate synthase activity
F1D59_RS26455	COG2226	methyltransferase
F1D59_RS26465	COG0477	Major facilitator Superfamily
F1D59_RS26470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1D59_RS26475	COG0584	glycerophosphoryl diester phosphodiesterase
F1D59_RS26480	COG0556	nucleotide-excision repair
F1D59_RS26500	COG0477	Major facilitator Superfamily
F1D59_RS26515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1D59_RS26545	COG0322	excinuclease ABC activity
F1D59_RS26550	COG1660	Displays ATPase and GTPase activities
F1D59_RS26555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F1D59_RS26560	COG1481	regulation of sporulation
F1D59_RS26570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1D59_RS26575	COG0126	phosphoglycerate kinase activity
F1D59_RS26580	COG0149	triose-phosphate isomerase activity
F1D59_RS26585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1D59_RS26595	COG0166	Belongs to the GPI family
F1D59_RS26600	COG0363	glucosamine-6-phosphate deaminase activity
F1D59_RS26615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1D59_RS26625	COG0109	protoheme IX farnesyltransferase activity
F1D59_RS26640	COG1612	heme a metabolic process
F1D59_RS26655	COG1131	(ABC) transporter
F1D59_RS26670	COG0719	Fe-S assembly protein
F1D59_RS26680	COG0396	ATPase activity
F1D59_RS26685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1D59_RS26690	COG0822	iron-sulfur transferase activity
F1D59_RS26710	COG2076	Multidrug Resistance protein
F1D59_RS26715	COG3226	Transcriptional regulator
F1D59_RS26730	COG2171	N-acyltransferase activity
F1D59_RS26800	COG4585	Histidine kinase
F1D59_RS26805	COG2197	response regulator
F1D59_RS26810	COG0768	penicillin binding
F1D59_RS26825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1D59_RS26855	COG1797	cobyrinic acid a,c-diamide synthase activity
F1D59_RS26870	COG1492	cobalamin metabolic process
F1D59_RS26875	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F1D59_RS26910	COG0488	(ABC) transporter
F1D59_RS26920	COG1024	Enoyl-CoA hydratase
F1D59_RS26965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F1D59_RS27015	COG1404	Belongs to the peptidase S8 family
F1D59_RS27025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1D59_RS27030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1D59_RS27050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F1D59_RS27065	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS27070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F1D59_RS27080	COG2186	Transcriptional regulator
F1D59_RS27100	COG3830	Belongs to the UPF0237 family
F1D59_RS27100	COG0560	Phosphoserine phosphatase
F1D59_RS27110	COG1716	ATPase activity
F1D59_RS27110	COG1131	(ABC) transporter
F1D59_RS27110	COG0842	Transport permease protein
F1D59_RS27120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F1D59_RS27130	COG4585	Histidine kinase
F1D59_RS27135	COG2197	response regulator
F1D59_RS27155	COG1119	ATPase activity
F1D59_RS27180	COG1881	PFAM PEBP family protein
F1D59_RS27190	COG2094	Belongs to the DNA glycosylase MPG family
F1D59_RS27220	COG0647	UMP catabolic process
F1D59_RS27225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1D59_RS27230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1D59_RS27235	COG1120	ATPase activity
F1D59_RS27255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F1D59_RS27260	COG0497	DNA recombination
F1D59_RS27275	COG0277	FAD linked oxidase domain protein
F1D59_RS27280	COG3387	PFAM Glycoside hydrolase 15-related
F1D59_RS27285	COG0504	CTP synthase activity
F1D59_RS27290	COG0494	nUDIX hydrolase
F1D59_RS27300	COG0686	Belongs to the AlaDH PNT family
F1D59_RS27315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F1D59_RS27320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1D59_RS27325	COG1187	pseudouridine synthase activity
F1D59_RS27345	COG1397	ADP-ribosylglycohydrolase
F1D59_RS27350	COG3541	Predicted nucleotidyltransferase
F1D59_RS27380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F1D59_RS27390	COG1160	GTP binding
F1D59_RS27405	COG3583	domain protein
F1D59_RS27415	COG0671	phosphoesterase, PA-phosphatase related
F1D59_RS27430	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS27435	COG1799	cell septum assembly
F1D59_RS27475	COG0641	radical SAM
F1D59_RS27495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F1D59_RS27505	COG0587	DNA-directed DNA polymerase activity
F1D59_RS27510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1D59_RS27515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F1D59_RS27540	COG1725	Transcriptional regulator
F1D59_RS27550	COG2755	lipolytic protein G-D-S-L family
F1D59_RS27565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1D59_RS27595	COG2188	Transcriptional regulator
F1D59_RS27600	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F1D59_RS27620	COG1309	transcriptional regulator
F1D59_RS27625	COG0243	molybdopterin cofactor binding
F1D59_RS27630	COG2851	Citrate transporter
F1D59_RS27650	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS27670	COG0789	Transcriptional regulator
F1D59_RS27690	COG3876	Protein conserved in bacteria
F1D59_RS27700	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS27710	COG1902	pentaerythritol trinitrate reductase activity
F1D59_RS27720	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS27730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1D59_RS27745	COG2149	membrane
F1D59_RS27750	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F1D59_RS27775	COG1113	amino acid transport
F1D59_RS27790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1D59_RS27820	COG0667	Aldo Keto reductase
F1D59_RS27825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS27835	COG0598	Magnesium transport protein CorA
F1D59_RS27855	COG0215	cysteine-tRNA ligase activity
F1D59_RS27865	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F1D59_RS27870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F1D59_RS27875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F1D59_RS27880	COG1414	Transcriptional regulator
F1D59_RS27885	COG1410	methionine synthase
F1D59_RS27885	COG0646	methionine synthase
F1D59_RS27895	COG4166	transmembrane transport
F1D59_RS27905	COG2197	response regulator
F1D59_RS27915	COG1994	Peptidase M50
F1D59_RS27915	COG0517	IMP dehydrogenase activity
F1D59_RS27935	COG1222	aaa ATPase
F1D59_RS27940	COG4122	O-methyltransferase activity
F1D59_RS27955	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F1D59_RS27960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F1D59_RS27965	COG1609	Transcriptional regulator
F1D59_RS27975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F1D59_RS28010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1D59_RS28015	COG0805	protein transport
F1D59_RS28030	COG0564	pseudouridine synthase activity
F1D59_RS28035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1D59_RS28045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1D59_RS28090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F1D59_RS28095	COG1113	amino acid transport
F1D59_RS28105	COG0174	glutamine synthetase
F1D59_RS28110	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS28115	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS28150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F1D59_RS28155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F1D59_RS28160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F1D59_RS28165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1D59_RS28170	COG5002	protein histidine kinase activity
F1D59_RS28175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F1D59_RS28180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1D59_RS28180	COG0072	phenylalanine-tRNA ligase activity
F1D59_RS28205	COG1649	PFAM Uncharacterised BCR, COG1649
F1D59_RS28215	COG0697	spore germination
F1D59_RS28230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F1D59_RS28235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F1D59_RS28240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1D59_RS28245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1D59_RS28250	COG1438	arginine binding
F1D59_RS28275	COG0137	argininosuccinate synthase activity
F1D59_RS28280	COG0165	Argininosuccinate lyase
F1D59_RS28300	COG0477	Major facilitator Superfamily
F1D59_RS28310	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS28310	COG0204	Acyl-transferase
F1D59_RS28340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1D59_RS28345	COG2011	ABC-type metal ion transport system permease component
F1D59_RS28350	COG1464	Belongs to the NlpA lipoprotein family
F1D59_RS28365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F1D59_RS28370	COG1648	precorrin-2 dehydrogenase activity
F1D59_RS28370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F1D59_RS28415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1D59_RS28420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1D59_RS28470	COG2176	DNA-directed DNA polymerase activity
F1D59_RS28470	COG5002	protein histidine kinase activity
F1D59_RS28485	COG0456	acetyltransferase
F1D59_RS28490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1D59_RS28515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1D59_RS28520	COG1560	Kdo2-lipid A biosynthetic process
F1D59_RS28525	COG0438	transferase activity, transferring glycosyl groups
F1D59_RS28535	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F1D59_RS28540	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F1D59_RS28545	COG0217	transcriptional regulatory protein
F1D59_RS28550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F1D59_RS28555	COG0632	four-way junction helicase activity
F1D59_RS28560	COG2255	four-way junction helicase activity
F1D59_RS28570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1D59_RS28575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1D59_RS28580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1D59_RS28585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1D59_RS28590	COG1196	nuclear chromosome segregation
F1D59_RS28595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1D59_RS28605	COG0124	histidyl-tRNA synthetase
F1D59_RS28630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F1D59_RS28650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1D59_RS28655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F1D59_RS28665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1D59_RS28675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F1D59_RS28680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1D59_RS28685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F1D59_RS28690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F1D59_RS28700	COG0006	proline dipeptidase activity
F1D59_RS28705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F1D59_RS28710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1D59_RS28720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F1D59_RS28725	COG0540	Belongs to the ATCase OTCase family
F1D59_RS28730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1D59_RS28740	COG0505	Belongs to the CarA family
F1D59_RS28745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F1D59_RS28750	COG0167	dihydroorotate dehydrogenase activity
F1D59_RS28755	COG0284	orotidine-5'-phosphate decarboxylase activity
F1D59_RS28765	COG0194	GDP metabolic process
F1D59_RS28780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F1D59_RS28795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1D59_RS28840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F1D59_RS28845	COG2390	Transcriptional regulator
F1D59_RS28875	COG0492	ferredoxin-NADP+ reductase activity
F1D59_RS28890	COG0028	Belongs to the TPP enzyme family
F1D59_RS28930	COG1366	Belongs to the anti-sigma-factor antagonist family
F1D59_RS28950	COG2208	phosphoserine phosphatase activity
F1D59_RS28950	COG2770	Histidine kinase
F1D59_RS28965	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS29005	COG3548	integral membrane protein
F1D59_RS29030	COG3275	phosphorelay sensor kinase activity
F1D59_RS29055	COG2755	lipolytic protein G-D-S-L family
F1D59_RS29060	COG0531	amino acid
F1D59_RS29075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1D59_RS29095	COG2233	PERMEase
F1D59_RS29100	COG0738	Major facilitator superfamily
F1D59_RS29105	COG1940	carbohydrate kinase activity
F1D59_RS29105	COG1846	Transcriptional regulator
F1D59_RS29125	COG1595	DNA-templated transcription, initiation
F1D59_RS29145	COG3201	nicotinamide mononucleotide transporter
F1D59_RS29150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1D59_RS29150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1D59_RS29155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F1D59_RS29160	COG0140	phosphoribosyl-ATP diphosphatase activity
F1D59_RS29165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F1D59_RS29190	COG0572	uridine kinase
F1D59_RS29210	COG1309	transcriptional regulator
F1D59_RS29215	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS29230	COG2801	Transposase and inactivated derivatives
F1D59_RS29260	COG0463	Glycosyl transferase, family 2
F1D59_RS29320	COG1984	allophanate hydrolase subunit 2
F1D59_RS29325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F1D59_RS29330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F1D59_RS29360	COG2018	Roadblock/LC7 domain
F1D59_RS29390	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F1D59_RS29395	COG1051	belongs to the nudix hydrolase family
F1D59_RS29405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1D59_RS29415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1D59_RS29445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F1D59_RS29485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1D59_RS29495	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1D59_RS29495	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F1D59_RS29530	COG1695	Transcriptional regulator
F1D59_RS29545	COG0697	spore germination
F1D59_RS29605	COG0477	Major facilitator Superfamily
F1D59_RS29630	COG0747	negative chemotaxis
F1D59_RS29635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F1D59_RS29650	COG2318	DinB family
F1D59_RS29655	COG0673	inositol 2-dehydrogenase activity
F1D59_RS29675	COG1968	undecaprenyl-diphosphatase activity
F1D59_RS29690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1D59_RS29740	COG0110	maltose O-acetyltransferase activity
F1D59_RS29755	COG1832	CoA-binding protein
F1D59_RS29760	COG1739	Uncharacterized protein family UPF0029
F1D59_RS29765	COG0420	3'-5' exonuclease activity
F1D59_RS29770	COG0419	ATPase involved in DNA repair
F1D59_RS29775	COG1522	sequence-specific DNA binding
F1D59_RS29805	COG2188	Transcriptional regulator
F1D59_RS29810	COG1940	carbohydrate kinase activity
F1D59_RS29815	COG2197	response regulator
F1D59_RS29820	COG4585	Histidine kinase
F1D59_RS29850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F1D59_RS29870	COG0456	acetyltransferase
F1D59_RS29875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F1D59_RS29880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F1D59_RS29885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F1D59_RS29890	COG0156	8-amino-7-oxononanoate synthase activity
F1D59_RS29910	COG0831	urea catabolic process
F1D59_RS29915	COG0832	Belongs to the urease beta subunit family
F1D59_RS29920	COG0804	urea catabolic process
F1D59_RS29930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F1D59_RS29935	COG0829	nickel cation binding
F1D59_RS29945	COG0204	Acyl-transferase
F1D59_RS29960	COG0205	6-phosphofructokinase activity
F1D59_RS29965	COG3442	glutamine amidotransferase
F1D59_RS29975	COG0242	peptide deformylase activity
F1D59_RS29985	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS30020	COG0601	transmembrane transport
F1D59_RS30025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1D59_RS30055	COG2814	Major facilitator Superfamily
F1D59_RS30060	COG0300	oxidoreductase activity
F1D59_RS30070	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS30080	COG2977	Belongs to the P-Pant transferase superfamily
F1D59_RS30120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1D59_RS30125	COG0473	3-isopropylmalate dehydrogenase activity
F1D59_RS30130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1D59_RS30140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1D59_RS30145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1D59_RS30155	COG1605	Chorismate mutase
F1D59_RS30170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1D59_RS30170	COG0512	Glutamine amidotransferase of anthranilate synthase
F1D59_RS30175	COG2814	Major facilitator Superfamily
F1D59_RS30180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS30185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS30190	COG0156	8-amino-7-oxononanoate synthase activity
F1D59_RS30195	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS30200	COG0183	Belongs to the thiolase family
F1D59_RS30205	COG2124	cytochrome p450
F1D59_RS30215	COG2319	Wd-40 repeat
F1D59_RS30215	COG4249	Peptidase C14 caspase catalytic subunit p20
F1D59_RS30235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS30250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F1D59_RS30275	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS30280	COG2824	Alkylphosphonate utilization operon protein PhnA
F1D59_RS30310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F1D59_RS30330	COG0702	epimerase
F1D59_RS30360	COG2409	Drug exporters of the RND superfamily
F1D59_RS30390	COG2197	response regulator
F1D59_RS30390	COG3903	Transcriptional regulator
F1D59_RS30420	COG3321	synthase
F1D59_RS30420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS30425	COG2409	Drug exporters of the RND superfamily
F1D59_RS30445	COG1846	Transcriptional regulator
F1D59_RS30475	COG0617	tRNA 3'-terminal CCA addition
F1D59_RS30490	COG2837	iron assimilation
F1D59_RS30510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F1D59_RS30520	COG0693	protein deglycase activity
F1D59_RS30545	COG2205	protein histidine kinase activity
F1D59_RS30550	COG0745	RESPONSE REGULATOR receiver
F1D59_RS30565	COG0785	Cytochrome C biogenesis protein
F1D59_RS30585	COG2340	Cysteine-rich secretory protein family
F1D59_RS30595	COG2957	Belongs to the agmatine deiminase family
F1D59_RS30610	COG2957	Belongs to the agmatine deiminase family
F1D59_RS30620	COG0831	urea catabolic process
F1D59_RS30620	COG0832	Belongs to the urease beta subunit family
F1D59_RS30625	COG0804	urea catabolic process
F1D59_RS30635	COG0747	negative chemotaxis
F1D59_RS30645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1D59_RS30685	COG2188	Transcriptional regulator
F1D59_RS30705	COG3842	ATPase activity
F1D59_RS30715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1D59_RS30730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F1D59_RS30755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1D59_RS30760	COG2326	polyphosphate kinase activity
F1D59_RS30770	COG0596	Alpha beta hydrolase
F1D59_RS30775	COG2267	carboxylic ester hydrolase activity
F1D59_RS30790	COG2409	Drug exporters of the RND superfamily
F1D59_RS30795	COG4585	Histidine kinase
F1D59_RS30800	COG2197	response regulator
F1D59_RS30805	COG2205	protein histidine kinase activity
F1D59_RS30810	COG0745	RESPONSE REGULATOR receiver
F1D59_RS30825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1D59_RS30865	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS30880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1D59_RS30945	COG2018	Roadblock/LC7 domain
F1D59_RS30955	COG3012	SEC-C Motif Domain Protein
F1D59_RS30960	COG1946	Acyl-CoA thioesterase
F1D59_RS30975	COG1132	(ABC) transporter
F1D59_RS30980	COG1132	(ABC) transporter
F1D59_RS30985	COG0277	FAD linked oxidase domain protein
F1D59_RS30995	COG1132	(ABC) transporter
F1D59_RS31005	COG2072	flavoprotein involved in K transport
F1D59_RS31010	COG2124	cytochrome p450
F1D59_RS31015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1D59_RS31030	COG0406	alpha-ribazole phosphatase activity
F1D59_RS31050	COG0475	glutathione-regulated potassium exporter activity
F1D59_RS31085	COG3251	PFAM MbtH domain protein
F1D59_RS31090	COG2124	cytochrome p450
F1D59_RS31145	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F1D59_RS31155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1D59_RS31160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS31160	COG3433	isochorismatase activity
F1D59_RS31160	COG2226	methyltransferase
F1D59_RS31175	COG3629	intracellular signal transduction
F1D59_RS31175	COG3903	Transcriptional regulator
F1D59_RS31200	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
F1D59_RS31215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F1D59_RS31230	COG1902	pentaerythritol trinitrate reductase activity
F1D59_RS31235	COG0640	Transcriptional regulator
F1D59_RS31245	COG0493	'glutamate synthase
F1D59_RS31270	COG0671	phosphoesterase, PA-phosphatase related
F1D59_RS31300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS31355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F1D59_RS31370	COG0494	nUDIX hydrolase
F1D59_RS31375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1D59_RS31435	COG1940	carbohydrate kinase activity
F1D59_RS31450	COG1733	regulation of RNA biosynthetic process
F1D59_RS31470	COG0464	growth
F1D59_RS31490	COG0463	Glycosyl transferase, family 2
F1D59_RS31495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F1D59_RS31515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F1D59_RS31550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1D59_RS31585	COG0842	Transport permease protein
F1D59_RS31585	COG1716	ATPase activity
F1D59_RS31585	COG1131	(ABC) transporter
F1D59_RS31665	COG1461	Dihydroxyacetone kinase
F1D59_RS31670	COG4191	Histidine kinase
F1D59_RS31685	COG0714	Associated with various cellular activities
F1D59_RS31725	COG2259	Doxx family
F1D59_RS31730	COG3387	PFAM Glycoside hydrolase 15-related
F1D59_RS31745	COG0477	Major facilitator Superfamily
F1D59_RS31765	COG1063	alcohol dehydrogenase
F1D59_RS31770	COG0156	8-amino-7-oxononanoate synthase activity
F1D59_RS31780	COG1349	DNA-binding transcription factor activity
F1D59_RS31785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1D59_RS31800	COG2318	DinB family
F1D59_RS31805	COG1960	acyl-CoA dehydrogenase activity
F1D59_RS31820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1D59_RS31820	COG0617	tRNA 3'-terminal CCA addition
F1D59_RS31820	COG0517	IMP dehydrogenase activity
F1D59_RS31865	COG1131	(ABC) transporter
F1D59_RS31885	COG0589	response to stress
F1D59_RS31905	COG1063	alcohol dehydrogenase
F1D59_RS31910	COG0517	IMP dehydrogenase activity
F1D59_RS31910	COG0516	GMP reductase activity
F1D59_RS31915	COG2124	cytochrome p450
F1D59_RS31935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1D59_RS31940	COG4591	ABC-type transport system involved in lipoprotein release permease component
F1D59_RS31940	COG1136	(ABC) transporter
F1D59_RS31955	COG0577	efflux transmembrane transporter activity
F1D59_RS31955	COG1136	(ABC) transporter
F1D59_RS32060	COG0515	serine threonine protein kinase
F1D59_RS32060	COG2815	serine threonine protein kinase
F1D59_RS32075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS32100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1D59_RS32105	COG2070	2-Nitropropane dioxygenase
F1D59_RS32115	COG0387	Pfam Sodium calcium exchanger
F1D59_RS32120	COG2366	antibiotic biosynthetic process
F1D59_RS32125	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS32160	COG1024	Enoyl-CoA hydratase
F1D59_RS32190	COG1672	PFAM Archaeal ATPase
F1D59_RS32190	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F1D59_RS32205	COG1053	succinate dehydrogenase
F1D59_RS32230	COG2010	Cytochrome c
F1D59_RS32230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F1D59_RS32235	COG2080	2 iron, 2 sulfur cluster binding
F1D59_RS32245	COG0531	amino acid
F1D59_RS32285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1D59_RS32295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F1D59_RS32335	COG0477	Major facilitator Superfamily
F1D59_RS32355	COG2378	regulation of single-species biofilm formation
F1D59_RS32395	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS32405	COG0604	alcohol dehydrogenase
F1D59_RS32445	COG0592	DNA-directed DNA polymerase activity
F1D59_RS32485	COG0513	Belongs to the DEAD box helicase family
F1D59_RS32490	COG1846	Transcriptional regulator
F1D59_RS32500	COG1278	Cold shock
F1D59_RS32530	COG4941	Belongs to the sigma-70 factor family
F1D59_RS32550	COG1136	(ABC) transporter
F1D59_RS32550	COG4591	ABC-type transport system involved in lipoprotein release permease component
F1D59_RS32555	COG4585	Histidine kinase
F1D59_RS32560	COG2197	response regulator
F1D59_RS32570	COG0583	DNA-binding transcription factor activity
F1D59_RS32595	COG2272	Belongs to the type-B carboxylesterase lipase family
F1D59_RS32620	COG1609	Transcriptional regulator
F1D59_RS32640	COG2318	DinB family
F1D59_RS32655	COG0657	acetylesterase activity
F1D59_RS32675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1D59_RS32685	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1D59_RS32690	COG3473	Maleate cis-trans isomerase
F1D59_RS32750	COG1404	Belongs to the peptidase S8 family
F1D59_RS32780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1D59_RS32795	COG0477	Major facilitator Superfamily
F1D59_RS32830	COG0435	Glutathione S-transferase
F1D59_RS32855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1D59_RS32880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F1D59_RS32880	COG1796	DNA polymerase
F1D59_RS32940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1D59_RS32945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS32960	COG0431	NADPH-dependent FMN reductase
F1D59_RS33000	COG2197	response regulator
F1D59_RS33005	COG4585	Histidine kinase
F1D59_RS33015	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F1D59_RS33045	COG4989	oxidoreductase activity
F1D59_RS33075	COG1505	serine-type exopeptidase activity
F1D59_RS33080	COG3387	PFAM Glycoside hydrolase 15-related
F1D59_RS33090	COG1309	transcriptional regulator
F1D59_RS33110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1D59_RS33125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F1D59_RS33140	COG1376	ErfK ybiS ycfS ynhG family protein
F1D59_RS33165	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS33220	COG1695	Transcriptional regulator
F1D59_RS33250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F1D59_RS33280	COG0557	exoribonuclease II activity
F1D59_RS33310	COG2318	DinB family
F1D59_RS33345	COG1595	DNA-templated transcription, initiation
F1D59_RS33365	COG1846	Transcriptional regulator
F1D59_RS33405	COG0598	Magnesium transport protein CorA
F1D59_RS33410	COG3119	arylsulfatase activity
F1D59_RS33420	COG3023	N-Acetylmuramoyl-L-alanine amidase
F1D59_RS33435	COG1595	DNA-templated transcription, initiation
F1D59_RS33445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1D59_RS33455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1D59_RS33460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1D59_RS33580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1D59_RS33595	COG0659	secondary active sulfate transmembrane transporter activity
F1D59_RS33615	COG2824	Alkylphosphonate utilization operon protein PhnA
F1D59_RS33660	COG2217	Heavy metal translocating P-type atpase
F1D59_RS33685	COG1105	Belongs to the carbohydrate kinase PfkB family
F1D59_RS33700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1D59_RS33725	COG0517	IMP dehydrogenase activity
F1D59_RS33735	COG1131	(ABC) transporter
F1D59_RS33745	COG0517	IMP dehydrogenase activity
F1D59_RS33745	COG0516	GMP reductase activity
F1D59_RS33755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F1D59_RS33775	COG0574	Belongs to the PEP-utilizing enzyme family
F1D59_RS33775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1D59_RS33795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1D59_RS33830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1D59_RS33830	COG0617	tRNA 3'-terminal CCA addition
F1D59_RS33830	COG0517	IMP dehydrogenase activity
F1D59_RS33840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1D59_RS33870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1D59_RS33915	COG2239	Acts as a magnesium transporter
F1D59_RS33920	COG0516	GMP reductase activity
F1D59_RS33920	COG0517	IMP dehydrogenase activity
F1D59_RS33925	COG0517	IMP dehydrogenase activity
F1D59_RS33925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1D59_RS33925	COG0617	tRNA 3'-terminal CCA addition
F1D59_RS33935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1D59_RS33945	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1D59_RS33945	COG0022	dehydrogenase e1 component
F1D59_RS33960	COG0589	response to stress
F1D59_RS33970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1D59_RS33980	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F1D59_RS34015	COG2235	arginine
F1D59_RS34020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1D59_RS34025	COG0549	Belongs to the carbamate kinase family
F1D59_RS34030	COG1288	antiporter activity
F1D59_RS34045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1D59_RS34045	COG0617	tRNA 3'-terminal CCA addition
F1D59_RS34045	COG0517	IMP dehydrogenase activity
F1D59_RS34050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1D59_RS34055	COG1454	alcohol dehydrogenase
F1D59_RS34055	COG1012	belongs to the aldehyde dehydrogenase family
F1D59_RS34070	COG0574	Belongs to the PEP-utilizing enzyme family
F1D59_RS34070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1D59_RS34080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F1D59_RS34085	COG0589	response to stress
F1D59_RS34130	COG0492	ferredoxin-NADP+ reductase activity
F1D59_RS34135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1D59_RS34155	COG2072	flavoprotein involved in K transport
F1D59_RS34160	COG0789	Transcriptional regulator
F1D59_RS34175	COG1247	-acetyltransferase
F1D59_RS34180	COG0640	Transcriptional regulator
F1D59_RS34210	COG1609	Transcriptional regulator
F1D59_RS34215	COG4952	isomerase
F1D59_RS34220	COG3347	Dehydrogenase
F1D59_RS34220	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS34225	COG1070	Carbohydrate kinase
F1D59_RS34245	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS34255	COG4106	trans-aconitate 2-methyltransferase activity
F1D59_RS34280	COG3173	Aminoglycoside phosphotransferase
F1D59_RS34300	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1D59_RS34305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1D59_RS34310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1D59_RS34320	COG2175	clavaminate synthase activity
F1D59_RS34360	COG1132	(ABC) transporter
F1D59_RS34365	COG1132	(ABC) transporter
F1D59_RS34375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS34410	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F1D59_RS34415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS34425	COG1834	amidinotransferase
F1D59_RS34450	COG3903	Transcriptional regulator
F1D59_RS34450	COG3629	intracellular signal transduction
F1D59_RS34460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F1D59_RS34465	COG1733	regulation of RNA biosynthetic process
F1D59_RS34480	COG1937	Protein conserved in bacteria
F1D59_RS34485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
F1D59_RS34490	COG0730	response to heat
F1D59_RS34495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1D59_RS34500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1D59_RS34500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1D59_RS34585	COG2378	regulation of single-species biofilm formation
F1D59_RS34635	COG2274	protein secretion by the type I secretion system
F1D59_RS34655	COG0514	ATP-dependent DNA helicase (RecQ)
F1D59_RS34695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1D59_RS34740	COG2226	methyltransferase
F1D59_RS34755	COG1846	Transcriptional regulator
F1D59_RS34785	COG2182	Extracellular solute-binding protein
F1D59_RS34805	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F1D59_RS34810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F1D59_RS34815	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F1D59_RS34825	COG0531	amino acid
F1D59_RS34835	COG0148	phosphopyruvate hydratase activity
F1D59_RS34865	COG2801	Transposase and inactivated derivatives
F1D59_RS34865	COG3415	Transposase
F1D59_RS34885	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1D59_RS34890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1D59_RS34900	COG0069	glutamate synthase activity
F1D59_RS34905	COG0028	Belongs to the TPP enzyme family
F1D59_RS34915	COG1295	ribonuclease BN
F1D59_RS34915	COG1959	2 iron, 2 sulfur cluster binding
F1D59_RS34925	COG0515	serine threonine protein kinase
F1D59_RS34935	COG1132	(ABC) transporter
F1D59_RS34940	COG1132	(ABC) transporter
F1D59_RS34945	COG2197	response regulator
F1D59_RS34985	COG1191	sigma factor activity
F1D59_RS35045	COG0137	argininosuccinate synthase activity
F1D59_RS35055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1D59_RS35070	COG2197	response regulator
F1D59_RS35095	COG1316	TRANSCRIPTIONal
F1D59_RS35110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F1D59_RS35110	COG2755	lipolytic protein G-D-S-L family
F1D59_RS35120	COG3046	protein related to deoxyribodipyrimidine photolyase
F1D59_RS35165	COG3250	beta-galactosidase activity
F1D59_RS35170	COG2249	NAD(P)H dehydrogenase (quinone) activity
F1D59_RS35185	COG0702	epimerase
F1D59_RS35210	COG1733	regulation of RNA biosynthetic process
F1D59_RS35225	COG2508	Transcriptional regulator
F1D59_RS35225	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F1D59_RS35240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1D59_RS35275	COG3848	Pyruvate phosphate dikinase
F1D59_RS35275	COG0574	Belongs to the PEP-utilizing enzyme family
F1D59_RS35305	COG1309	transcriptional regulator
F1D59_RS35310	COG0667	Aldo Keto reductase
F1D59_RS35335	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS35360	COG0604	alcohol dehydrogenase
F1D59_RS35365	COG1902	pentaerythritol trinitrate reductase activity
F1D59_RS35370	COG1846	Transcriptional regulator
F1D59_RS35375	COG0181	hydroxymethylbilane synthase activity
F1D59_RS35395	COG1051	belongs to the nudix hydrolase family
F1D59_RS35450	COG2326	polyphosphate kinase activity
F1D59_RS35485	COG0583	DNA-binding transcription factor activity
F1D59_RS35490	COG1819	glycosyl
F1D59_RS35495	COG0583	DNA-binding transcription factor activity
F1D59_RS35510	COG1819	glycosyl
F1D59_RS35535	COG0395	ABC-type sugar transport system, permease component
F1D59_RS35540	COG1175	transmembrane transport
F1D59_RS35550	COG0366	Alpha amylase catalytic
F1D59_RS35555	COG1653	transport
F1D59_RS35565	COG1136	(ABC) transporter
F1D59_RS35585	COG2376	Dihydroxyacetone kinase
F1D59_RS35595	COG0367	asparagine synthase
F1D59_RS35610	COG1247	-acetyltransferase
F1D59_RS35625	COG0640	Transcriptional regulator
F1D59_RS35655	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1D59_RS35675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS35685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1D59_RS35735	COG2326	polyphosphate kinase activity
F1D59_RS35755	COG2124	cytochrome p450
F1D59_RS35760	COG0517	IMP dehydrogenase activity
F1D59_RS35775	COG4221	oxidoreductase activity
F1D59_RS35790	COG0598	Magnesium transport protein CorA
F1D59_RS35795	COG1295	ribonuclease BN
F1D59_RS35820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F1D59_RS35825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F1D59_RS35830	COG0488	(ABC) transporter
F1D59_RS35870	COG0477	Major facilitator Superfamily
F1D59_RS35875	COG0531	amino acid
F1D59_RS35890	COG1309	transcriptional regulator
F1D59_RS35895	COG0596	Alpha beta hydrolase
F1D59_RS35905	COG0583	DNA-binding transcription factor activity
F1D59_RS35950	COG0477	Major facilitator Superfamily
F1D59_RS35960	COG2045	Belongs to the ComB family
F1D59_RS35975	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
F1D59_RS35990	COG0583	DNA-binding transcription factor activity
F1D59_RS35995	COG2124	cytochrome p450
F1D59_RS36000	COG1595	DNA-templated transcription, initiation
F1D59_RS36010	COG1131	(ABC) transporter
F1D59_RS36045	COG1132	(ABC) transporter
F1D59_RS36050	COG1309	transcriptional regulator
F1D59_RS36100	COG3119	arylsulfatase activity
F1D59_RS36105	COG0435	Glutathione S-transferase
F1D59_RS36110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1D59_RS36120	COG1116	anion transmembrane transporter activity
F1D59_RS36155	COG0402	S-adenosylhomocysteine deaminase activity
F1D59_RS36170	COG4585	Histidine kinase
F1D59_RS36175	COG0477	Major facilitator Superfamily
F1D59_RS36190	COG0318	PFAM AMP-dependent synthetase and ligase
F1D59_RS36210	COG4941	Belongs to the sigma-70 factor family
F1D59_RS36215	COG3795	YCII-related domain
F1D59_RS36240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1D59_RS36270	COG2197	response regulator
F1D59_RS36275	COG0583	DNA-binding transcription factor activity
F1D59_RS36280	COG0483	inositol monophosphate 1-phosphatase activity
F1D59_RS36285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1D59_RS36290	COG2080	2 iron, 2 sulfur cluster binding
F1D59_RS36295	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F1D59_RS36300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F1D59_RS36350	COG2124	cytochrome p450
F1D59_RS36370	COG0142	geranyltranstransferase activity
F1D59_RS36385	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F1D59_RS36400	COG1982	Orn Lys Arg decarboxylase major
F1D59_RS36435	COG0009	L-threonylcarbamoyladenylate synthase
F1D59_RS36445	COG1335	isochorismatase
F1D59_RS36460	COG0456	acetyltransferase
F1D59_RS36460	COG0454	-acetyltransferase
F1D59_RS36495	COG1595	DNA-templated transcription, initiation
F1D59_RS36530	COG2197	response regulator
F1D59_RS36590	COG2197	response regulator
F1D59_RS36605	COG1024	Enoyl-CoA hydratase
F1D59_RS36625	COG1309	transcriptional regulator
F1D59_RS36685	COG0583	DNA-binding transcription factor activity
F1D59_RS36705	COG2205	protein histidine kinase activity
F1D59_RS36710	COG0745	RESPONSE REGULATOR receiver
F1D59_RS36735	COG3864	Putative metallopeptidase domain
F1D59_RS36765	COG0668	transmembrane transport
F1D59_RS36805	COG0640	Transcriptional regulator
F1D59_RS36830	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1D59_RS36835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1D59_RS36865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1D59_RS36885	COG0784	Response regulator, receiver
F1D59_RS36890	COG4251	negative regulation of phosphorylation
F1D59_RS36920	COG0671	phosphoesterase, PA-phosphatase related
F1D59_RS36955	COG4106	trans-aconitate 2-methyltransferase activity
F1D59_RS37015	COG2208	phosphoserine phosphatase activity
F1D59_RS37015	COG2770	Histidine kinase
F1D59_RS37055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F1D59_RS37070	COG2207	Transcriptional regulator
F1D59_RS37070	COG3708	Transcriptional regulator
F1D59_RS37075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1D59_RS37095	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS37100	COG1309	transcriptional regulator
F1D59_RS37150	COG1028	Short-chain dehydrogenase reductase Sdr
F1D59_RS37200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1D59_RS37215	COG0745	RESPONSE REGULATOR receiver
F1D59_RS37220	COG5002	protein histidine kinase activity
F1D59_RS37240	COG4585	Histidine kinase
F1D59_RS37245	COG2197	response regulator
F1D59_RS37260	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F1D59_RS37265	COG0596	Alpha beta hydrolase
F1D59_RS37335	COG4213	ABC transporter substrate-binding protein