locus-tag	class	description
HUV60_RS00100	COG0513	Belongs to the DEAD box helicase family
HUV60_RS00135	COG2801	Transposase and inactivated derivatives
HUV60_RS00150	COG0326	Molecular chaperone. Has ATPase activity
HUV60_RS00215	COG2132	Multicopper oxidase
HUV60_RS00220	COG0745	RESPONSE REGULATOR receiver
HUV60_RS00230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUV60_RS00240	COG0154	amidase activity
HUV60_RS00270	COG2409	Drug exporters of the RND superfamily
HUV60_RS00275	COG1595	DNA-templated transcription, initiation
HUV60_RS00355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUV60_RS00360	COG1116	anion transmembrane transporter activity
HUV60_RS00380	COG0529	Catalyzes the synthesis of activated sulfate
HUV60_RS00390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUV60_RS00395	COG0596	Alpha beta hydrolase
HUV60_RS00405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUV60_RS00420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUV60_RS00425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUV60_RS00445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUV60_RS00490	COG1191	sigma factor activity
HUV60_RS00520	COG2801	Transposase and inactivated derivatives
HUV60_RS00555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUV60_RS00565	COG3594	Acyltransferase
HUV60_RS00685	COG0517	IMP dehydrogenase activity
HUV60_RS00685	COG0516	GMP reductase activity
HUV60_RS00695	COG0395	ABC-type sugar transport system, permease component
HUV60_RS00700	COG1175	transmembrane transport
HUV60_RS00710	COG1501	Belongs to the glycosyl hydrolase 31 family
HUV60_RS00720	COG1609	Transcriptional regulator
HUV60_RS00725	COG4209	transmembrane transport
HUV60_RS00730	COG0395	ABC-type sugar transport system, permease component
HUV60_RS00770	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUV60_RS00775	COG1120	ATPase activity
HUV60_RS00795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUV60_RS00810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUV60_RS00835	COG0667	Aldo Keto reductase
HUV60_RS00855	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUV60_RS00865	COG0410	ABC transporter
HUV60_RS00870	COG0789	Transcriptional regulator
HUV60_RS00880	COG2508	Transcriptional regulator
HUV60_RS00925	COG3290	protein histidine kinase activity
HUV60_RS01120	COG4221	oxidoreductase activity
HUV60_RS01135	COG1132	(ABC) transporter
HUV60_RS01260	COG2124	cytochrome p450
HUV60_RS01355	COG1357	PFAM Pentapeptide repeats (8 copies)
HUV60_RS01370	COG1609	Transcriptional regulator
HUV60_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS01400	COG3347	Dehydrogenase
HUV60_RS01405	COG1070	Carbohydrate kinase
HUV60_RS01410	COG0247	lactate metabolic process
HUV60_RS01415	COG1139	Iron-sulfur cluster binding protein
HUV60_RS01420	COG1556	Lactate utilization protein
HUV60_RS01435	COG2326	polyphosphate kinase activity
HUV60_RS01470	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUV60_RS01470	COG2755	lipolytic protein G-D-S-L family
HUV60_RS01495	COG0302	gtp cyclohydrolase
HUV60_RS01500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS01510	COG0720	synthase
HUV60_RS01565	COG0242	peptide deformylase activity
HUV60_RS01575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUV60_RS01585	COG1609	Transcriptional regulator
HUV60_RS01605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUV60_RS01610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUV60_RS01615	COG2080	2 iron, 2 sulfur cluster binding
HUV60_RS01630	COG0583	DNA-binding transcription factor activity
HUV60_RS01670	COG3572	ergothioneine biosynthetic process
HUV60_RS01675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUV60_RS01680	COG0121	glutamine amidotransferase
HUV60_RS01685	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUV60_RS01690	COG3360	Dodecin
HUV60_RS01700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUV60_RS01720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUV60_RS01725	COG1053	succinate dehydrogenase
HUV60_RS01735	COG0583	DNA-binding transcription factor activity
HUV60_RS01780	COG0726	polysaccharide deacetylase
HUV60_RS01875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUV60_RS01895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUV60_RS01910	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUV60_RS01930	COG4106	trans-aconitate 2-methyltransferase activity
HUV60_RS01950	COG0477	Major facilitator Superfamily
HUV60_RS01965	COG1175	transmembrane transport
HUV60_RS01970	COG0395	ABC-type sugar transport system, permease component
HUV60_RS02080	COG3344	reverse transcriptase
HUV60_RS02110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUV60_RS02110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUV60_RS02110	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HUV60_RS02110	COG3321	synthase
HUV60_RS02120	COG3845	ABC transporter
HUV60_RS02130	COG0601	transmembrane transport
HUV60_RS02145	COG3433	isochorismatase activity
HUV60_RS02145	COG2226	methyltransferase
HUV60_RS02145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS02165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUV60_RS02180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUV60_RS02185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUV60_RS02195	COG1132	(ABC) transporter
HUV60_RS02200	COG1132	(ABC) transporter
HUV60_RS02230	COG1120	ATPase activity
HUV60_RS02235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUV60_RS02240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUV60_RS02365	COG3851	Histidine kinase
HUV60_RS02370	COG2197	response regulator
HUV60_RS02380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUV60_RS02380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUV60_RS02395	COG0668	transmembrane transport
HUV60_RS02400	COG2838	Isocitrate dehydrogenase
HUV60_RS02445	COG2175	clavaminate synthase activity
HUV60_RS02465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUV60_RS02470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUV60_RS02475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUV60_RS02510	COG0673	inositol 2-dehydrogenase activity
HUV60_RS02515	COG3548	integral membrane protein
HUV60_RS02535	COG0673	inositol 2-dehydrogenase activity
HUV60_RS02565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUV60_RS02575	COG3718	enzyme involved in inositol metabolism
HUV60_RS02580	COG3962	Belongs to the TPP enzyme family
HUV60_RS02590	COG2188	Transcriptional regulator
HUV60_RS02690	COG0583	DNA-binding transcription factor activity
HUV60_RS02695	COG0156	8-amino-7-oxononanoate synthase activity
HUV60_RS02700	COG1063	alcohol dehydrogenase
HUV60_RS02735	COG2755	lipolytic protein G-D-S-L family
HUV60_RS02745	COG2365	Tyrosine phosphatase family
HUV60_RS02785	COG1657	PFAM Prenyltransferase squalene oxidase
HUV60_RS02795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUV60_RS02805	COG1562	ergosterol biosynthetic process
HUV60_RS02810	COG1134	teichoic acid transport
HUV60_RS02850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUV60_RS02865	COG1024	Enoyl-CoA hydratase
HUV60_RS02880	COG0488	(ABC) transporter
HUV60_RS02900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUV60_RS02905	COG2936	dipeptidyl-peptidase activity
HUV60_RS02920	COG1024	Enoyl-CoA hydratase
HUV60_RS02920	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUV60_RS02925	COG0183	Belongs to the thiolase family
HUV60_RS02930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUV60_RS02940	COG1515	deoxyribonuclease V activity
HUV60_RS02955	COG0488	(ABC) transporter
HUV60_RS02960	COG1834	amidinotransferase
HUV60_RS03000	COG1470	cell adhesion involved in biofilm formation
HUV60_RS03020	COG1672	PFAM Archaeal ATPase
HUV60_RS03020	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUV60_RS03080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUV60_RS03095	COG1486	melibiose metabolic process
HUV60_RS03115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUV60_RS03120	COG0406	alpha-ribazole phosphatase activity
HUV60_RS03140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUV60_RS03160	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS03190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUV60_RS03210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUV60_RS03220	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS03235	COG1201	RNA secondary structure unwinding
HUV60_RS03380	COG3344	reverse transcriptase
HUV60_RS03515	COG0673	inositol 2-dehydrogenase activity
HUV60_RS03520	COG1879	ABC-type sugar transport system periplasmic component
HUV60_RS03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUV60_RS03530	COG1129	ABC transporter
HUV60_RS03535	COG1940	carbohydrate kinase activity
HUV60_RS03545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUV60_RS03565	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUV60_RS03575	COG0656	L-ascorbic acid biosynthetic process
HUV60_RS03585	COG5297	Belongs to the glycosyl hydrolase family 6
HUV60_RS03590	COG5297	Belongs to the glycosyl hydrolase family 6
HUV60_RS03590	COG4733	cellulase activity
HUV60_RS03600	COG3401	FG-GAP repeat protein
HUV60_RS03605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUV60_RS03605	COG4106	trans-aconitate 2-methyltransferase activity
HUV60_RS03610	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUV60_RS03630	COG0443	Heat shock 70 kDa protein
HUV60_RS03660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUV60_RS03690	COG0693	protein deglycase activity
HUV60_RS03705	COG2226	methyltransferase
HUV60_RS03725	COG3958	Transketolase
HUV60_RS03745	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUV60_RS03755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUV60_RS03760	COG2362	D-Aminopeptidase
HUV60_RS03770	COG1366	Belongs to the anti-sigma-factor antagonist family
HUV60_RS03770	COG2172	sigma factor antagonist activity
HUV60_RS03770	COG2208	phosphoserine phosphatase activity
HUV60_RS03790	COG1082	Xylose isomerase domain protein TIM barrel
HUV60_RS03800	COG1129	ABC transporter
HUV60_RS03805	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUV60_RS03810	COG1879	ABC-type sugar transport system periplasmic component
HUV60_RS03815	COG2390	Transcriptional regulator
HUV60_RS03820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUV60_RS03825	COG3958	Transketolase
HUV60_RS03830	COG3959	Transketolase, thiamine diphosphate binding domain
HUV60_RS03850	COG0596	Alpha beta hydrolase
HUV60_RS03860	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUV60_RS03870	COG0604	alcohol dehydrogenase
HUV60_RS03875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS03875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS03880	COG2301	Belongs to the HpcH HpaI aldolase family
HUV60_RS03890	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS03895	COG0688	phosphatidylethanolamine metabolic process
HUV60_RS03905	COG1929	Belongs to the glycerate kinase type-1 family
HUV60_RS03960	COG1461	Dihydroxyacetone kinase
HUV60_RS03965	COG2376	Dihydroxyacetone kinase
HUV60_RS03980	COG0483	inositol monophosphate 1-phosphatase activity
HUV60_RS03995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUV60_RS04000	COG1605	Chorismate mutase
HUV60_RS04005	COG0287	Prephenate dehydrogenase
HUV60_RS04010	COG0287	Prephenate dehydrogenase
HUV60_RS04015	COG0512	Glutamine amidotransferase of anthranilate synthase
HUV60_RS04015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUV60_RS04020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUV60_RS04065	COG2890	protein-(glutamine-N5) methyltransferase activity
HUV60_RS04080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUV60_RS04085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUV60_RS04090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUV60_RS04110	COG0542	response to heat
HUV60_RS04115	COG0405	Gamma-glutamyltransferase
HUV60_RS04130	COG0708	Exodeoxyribonuclease III
HUV60_RS04135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUV60_RS04140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUV60_RS04195	COG3387	PFAM Glycoside hydrolase 15-related
HUV60_RS04225	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS04315	COG1132	(ABC) transporter
HUV60_RS04320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUV60_RS04340	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUV60_RS04345	COG0494	nUDIX hydrolase
HUV60_RS04370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUV60_RS04515	COG2223	nitrite transmembrane transporter activity
HUV60_RS04520	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUV60_RS04645	COG2801	Transposase and inactivated derivatives
HUV60_RS04645	COG3415	Transposase
HUV60_RS04695	COG0714	Associated with various cellular activities
HUV60_RS04855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUV60_RS04855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUV60_RS04930	COG2815	serine threonine protein kinase
HUV60_RS04930	COG0515	serine threonine protein kinase
HUV60_RS05000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS05005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS05015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS05040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS05050	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HUV60_RS05070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUV60_RS05075	COG1278	Cold shock
HUV60_RS05080	COG1024	Enoyl-CoA hydratase
HUV60_RS05085	COG1024	Enoyl-CoA hydratase
HUV60_RS05090	COG3424	synthase
HUV60_RS05105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUV60_RS05115	COG1132	(ABC) transporter
HUV60_RS05125	COG1131	(ABC) transporter
HUV60_RS05130	COG1725	Transcriptional regulator
HUV60_RS05135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS05150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS05205	COG3328	transposase activity
HUV60_RS05355	COG2188	Transcriptional regulator
HUV60_RS05365	COG1674	ftsk spoiiie
HUV60_RS05380	COG0582	viral genome integration into host DNA
HUV60_RS05400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUV60_RS05410	COG1940	carbohydrate kinase activity
HUV60_RS05415	COG2188	Transcriptional regulator
HUV60_RS05435	COG0515	serine threonine protein kinase
HUV60_RS05440	COG4266	Belongs to the allantoicase family
HUV60_RS05445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUV60_RS05450	COG1414	Transcriptional regulator
HUV60_RS05460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUV60_RS05465	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUV60_RS05525	COG0436	Aminotransferase
HUV60_RS05555	COG2351	hydroxyisourate hydrolase activity
HUV60_RS05575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUV60_RS05580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUV60_RS05590	COG0659	secondary active sulfate transmembrane transporter activity
HUV60_RS05595	COG0789	Transcriptional regulator
HUV60_RS05640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUV60_RS05640	COG3608	succinylglutamate desuccinylase aspartoacylase
HUV60_RS05645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUV60_RS05670	COG1802	Transcriptional regulator
HUV60_RS05695	COG0028	Belongs to the TPP enzyme family
HUV60_RS05710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUV60_RS05720	COG1162	GTPase activity
HUV60_RS05735	COG0277	FAD linked oxidase domain protein
HUV60_RS05750	COG1175	transmembrane transport
HUV60_RS05755	COG0395	ABC-type sugar transport system, permease component
HUV60_RS05780	COG3795	YCII-related domain
HUV60_RS05785	COG4941	Belongs to the sigma-70 factor family
HUV60_RS05790	COG2040	homocysteine
HUV60_RS05810	COG0460	homoserine dehydrogenase
HUV60_RS05815	COG1609	Transcriptional regulator
HUV60_RS05850	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS05870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUV60_RS05880	COG0175	sulfate reduction
HUV60_RS05885	COG0529	Catalyzes the synthesis of activated sulfate
HUV60_RS05910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HUV60_RS05915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUV60_RS06045	COG1732	Glycine betaine
HUV60_RS06050	COG1174	glycine betaine transport
HUV60_RS06055	COG1174	glycine betaine transport
HUV60_RS06085	COG5002	protein histidine kinase activity
HUV60_RS06090	COG0745	RESPONSE REGULATOR receiver
HUV60_RS06125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUV60_RS06130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUV60_RS06150	COG0330	HflC and HflK could
HUV60_RS06190	COG3220	belongs to the UPF0276 family
HUV60_RS06200	COG3253	May function as heme-dependent peroxidase
HUV60_RS06215	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUV60_RS06230	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUV60_RS06245	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUV60_RS06250	COG0183	Belongs to the thiolase family
HUV60_RS06255	COG1024	Enoyl-CoA hydratase
HUV60_RS06255	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUV60_RS06265	COG0531	amino acid
HUV60_RS06270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUV60_RS06275	COG4214	carbohydrate transport
HUV60_RS06285	COG4213	ABC transporter substrate-binding protein
HUV60_RS06290	COG1940	carbohydrate kinase activity
HUV60_RS06295	COG0395	ABC-type sugar transport system, permease component
HUV60_RS06300	COG1175	transmembrane transport
HUV60_RS06305	COG1653	transport
HUV60_RS06320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUV60_RS06330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUV60_RS06505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUV60_RS06510	COG0789	Transcriptional regulator
HUV60_RS06525	COG0463	Glycosyl transferase, family 2
HUV60_RS06585	COG0745	RESPONSE REGULATOR receiver
HUV60_RS06590	COG2205	protein histidine kinase activity
HUV60_RS06595	COG0183	Belongs to the thiolase family
HUV60_RS06600	COG0583	DNA-binding transcription factor activity
HUV60_RS06620	COG4608	Belongs to the ABC transporter superfamily
HUV60_RS06625	COG0444	Belongs to the ABC transporter superfamily
HUV60_RS06630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUV60_RS06635	COG0601	transmembrane transport
HUV60_RS06645	COG0310	cobalt ion transport
HUV60_RS06650	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HUV60_RS06660	COG1122	ATPase activity
HUV60_RS06710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUV60_RS06715	COG2235	arginine
HUV60_RS06775	COG4251	negative regulation of phosphorylation
HUV60_RS06805	COG1799	cell septum assembly
HUV60_RS06815	COG1253	flavin adenine dinucleotide binding
HUV60_RS06820	COG1472	Belongs to the glycosyl hydrolase 3 family
HUV60_RS06825	COG0395	ABC-type sugar transport system, permease component
HUV60_RS06830	COG1175	transmembrane transport
HUV60_RS06835	COG2182	Extracellular solute-binding protein
HUV60_RS06840	COG2188	Transcriptional regulator
HUV60_RS06865	COG3226	Transcriptional regulator
HUV60_RS06870	COG0110	maltose O-acetyltransferase activity
HUV60_RS06945	COG2770	Histidine kinase
HUV60_RS06945	COG2208	phosphoserine phosphatase activity
HUV60_RS06960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUV60_RS06975	COG0596	Alpha beta hydrolase
HUV60_RS06980	COG1278	Cold shock
HUV60_RS07005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUV60_RS07010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUV60_RS07015	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS07030	COG0367	asparagine synthase
HUV60_RS07055	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS07065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUV60_RS07080	COG4310	Domain of unknown function (DUF2172)
HUV60_RS07090	COG1215	transferase activity, transferring glycosyl groups
HUV60_RS07105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUV60_RS07115	COG0287	Prephenate dehydrogenase
HUV60_RS07140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUV60_RS07145	COG1215	transferase activity, transferring glycosyl groups
HUV60_RS07170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUV60_RS07175	COG2226	methyltransferase
HUV60_RS07185	COG2226	methyltransferase
HUV60_RS07195	COG1595	DNA-templated transcription, initiation
HUV60_RS07210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUV60_RS07215	COG0800	Aldolase
HUV60_RS07250	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS07255	COG0395	ABC-type sugar transport system, permease component
HUV60_RS07260	COG1175	transmembrane transport
HUV60_RS07265	COG2182	Extracellular solute-binding protein
HUV60_RS07270	COG1609	Transcriptional regulator
HUV60_RS07295	COG0730	response to heat
HUV60_RS07300	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUV60_RS07305	COG1937	Protein conserved in bacteria
HUV60_RS07360	COG2188	Transcriptional regulator
HUV60_RS07370	COG2188	Transcriptional regulator
HUV60_RS07420	COG3344	reverse transcriptase
HUV60_RS07490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUV60_RS07495	COG0531	amino acid
HUV60_RS07500	COG0569	domain protein
HUV60_RS07535	COG0756	dUTP diphosphatase activity
HUV60_RS07560	COG2205	protein histidine kinase activity
HUV60_RS07565	COG0745	RESPONSE REGULATOR receiver
HUV60_RS07580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUV60_RS07620	COG1435	thymidine kinase activity
HUV60_RS07635	COG1320	monovalent cation:proton antiporter activity
HUV60_RS07640	COG2212	antiporter activity
HUV60_RS07650	COG0651	ATP synthesis coupled electron transport
HUV60_RS07655	COG1006	Multisubunit Na H antiporter MnhC subunit
HUV60_RS07660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUV60_RS07660	COG2111	Na H antiporter
HUV60_RS07665	COG1042	CoA-binding domain protein
HUV60_RS07665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUV60_RS07665	COG0045	succinate-CoA ligase (ADP-forming) activity
HUV60_RS07670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUV60_RS07675	COG1802	Transcriptional regulator
HUV60_RS07690	COG0612	Peptidase, M16
HUV60_RS07695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUV60_RS07700	COG0523	cobalamin synthesis protein
HUV60_RS07730	COG0187	DNA topoisomerase II activity
HUV60_RS07745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUV60_RS07750	COG2186	Transcriptional regulator
HUV60_RS07755	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HUV60_RS07770	COG0514	ATP-dependent DNA helicase (RecQ)
HUV60_RS07785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUV60_RS07805	COG0588	phosphoglycerate mutase activity
HUV60_RS07820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUV60_RS07825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUV60_RS07830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUV60_RS07850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUV60_RS07860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUV60_RS07865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUV60_RS07875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUV60_RS07890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUV60_RS07900	COG2358	TRAP transporter, solute receptor (TAXI family
HUV60_RS07905	COG2205	protein histidine kinase activity
HUV60_RS07910	COG0745	RESPONSE REGULATOR receiver
HUV60_RS07915	COG1126	abc transporter atp-binding protein
HUV60_RS07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUV60_RS07925	COG0765	amino acid transport
HUV60_RS07930	COG0765	amino acid transport
HUV60_RS07935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUV60_RS07960	COG0628	permease
HUV60_RS07980	COG2207	Transcriptional regulator
HUV60_RS07980	COG1917	Cupin 2, conserved barrel domain protein
HUV60_RS07985	COG1201	RNA secondary structure unwinding
HUV60_RS07990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUV60_RS08000	COG0783	Belongs to the Dps family
HUV60_RS08005	COG1396	sequence-specific DNA binding
HUV60_RS08010	COG1058	Belongs to the CinA family
HUV60_RS08010	COG1546	Belongs to the CinA family
HUV60_RS08020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUV60_RS08030	COG1674	ftsk spoiiie
HUV60_RS08040	COG2205	protein histidine kinase activity
HUV60_RS08040	COG3437	response regulator, receiver
HUV60_RS08040	COG3850	Histidine kinase
HUV60_RS08040	COG4999	Histidine kinase
HUV60_RS08045	COG2770	Histidine kinase
HUV60_RS08045	COG2208	phosphoserine phosphatase activity
HUV60_RS08075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUV60_RS08080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUV60_RS08085	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUV60_RS08105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUV60_RS08110	COG0612	Peptidase, M16
HUV60_RS08115	COG1185	polyribonucleotide nucleotidyltransferase activity
HUV60_RS08120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUV60_RS08130	COG0455	bacterial-type flagellum organization
HUV60_RS08155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUV60_RS08160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUV60_RS08170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUV60_RS08185	COG0779	Required for maturation of 30S ribosomal subunits
HUV60_RS08205	COG0442	prolyl-tRNA aminoacylation
HUV60_RS08220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUV60_RS08225	COG0750	zinc metalloprotease
HUV60_RS08230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUV60_RS08265	COG0395	ABC-type sugar transport system, permease component
HUV60_RS08270	COG4209	transmembrane transport
HUV60_RS08275	COG1653	transport
HUV60_RS08285	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS08290	COG2508	Transcriptional regulator
HUV60_RS08315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUV60_RS08325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUV60_RS08330	COG0584	glycerophosphoryl diester phosphodiesterase
HUV60_RS08340	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS08355	COG1136	(ABC) transporter
HUV60_RS08380	COG3842	ATPase activity
HUV60_RS08385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HUV60_RS08395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUV60_RS08400	COG0575	Belongs to the CDS family
HUV60_RS08405	COG0233	cytoplasmic translational termination
HUV60_RS08410	COG0528	UMP kinase activity
HUV60_RS08415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUV60_RS08420	COG0052	Belongs to the universal ribosomal protein uS2 family
HUV60_RS08435	COG1191	sigma factor activity
HUV60_RS08450	COG0792	nuclease activity
HUV60_RS08465	COG0681	Belongs to the peptidase S26 family
HUV60_RS08480	COG0681	Belongs to the peptidase S26 family
HUV60_RS08485	COG0335	large ribosomal subunit rRNA binding
HUV60_RS08490	COG0336	Belongs to the RNA methyltransferase TrmD family
HUV60_RS08495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUV60_RS08500	COG1837	Belongs to the UPF0109 family
HUV60_RS08505	COG0228	four-way junction DNA binding
HUV60_RS08525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUV60_RS08570	COG1254	Belongs to the acylphosphatase family
HUV60_RS08575	COG2340	Cysteine-rich secretory protein family
HUV60_RS08580	COG1733	regulation of RNA biosynthetic process
HUV60_RS08585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUV60_RS08590	COG0571	ribonuclease III activity
HUV60_RS08595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUV60_RS08610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUV60_RS08615	COG0742	ribosomal rna small subunit methyltransferase
HUV60_RS08625	COG0326	Molecular chaperone. Has ATPase activity
HUV60_RS08635	COG1461	Dihydroxyacetone kinase
HUV60_RS08640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUV60_RS08645	COG0351	phosphomethylpyrimidine kinase
HUV60_RS08665	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUV60_RS08670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUV60_RS08680	COG1920	GTP binding
HUV60_RS08690	COG0776	regulation of translation
HUV60_RS08700	COG0066	3-isopropylmalate dehydratase activity
HUV60_RS08705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUV60_RS08745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUV60_RS08750	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUV60_RS08760	COG5002	protein histidine kinase activity
HUV60_RS08765	COG2018	Roadblock/LC7 domain
HUV60_RS08785	COG2018	Roadblock/LC7 domain
HUV60_RS08805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUV60_RS08810	COG0300	oxidoreductase activity
HUV60_RS08830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUV60_RS08835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUV60_RS08840	COG0473	3-isopropylmalate dehydrogenase activity
HUV60_RS08850	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS08855	COG0506	proline dehydrogenase activity
HUV60_RS08860	COG2508	Transcriptional regulator
HUV60_RS08875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUV60_RS08880	COG0440	acetolactate synthase activity
HUV60_RS08890	COG5001	Diguanylate cyclase
HUV60_RS08900	COG0667	Aldo Keto reductase
HUV60_RS08920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUV60_RS08925	COG2409	Drug exporters of the RND superfamily
HUV60_RS08935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUV60_RS08945	COG0154	amidase activity
HUV60_RS08950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUV60_RS08960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUV60_RS08970	COG4221	oxidoreductase activity
HUV60_RS08975	COG1611	Belongs to the LOG family
HUV60_RS09000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUV60_RS09045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUV60_RS09060	COG0482	sulfurtransferase activity
HUV60_RS09085	COG2860	membrane
HUV60_RS09090	COG4608	Belongs to the ABC transporter superfamily
HUV60_RS09095	COG0444	Belongs to the ABC transporter superfamily
HUV60_RS09100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUV60_RS09105	COG0601	transmembrane transport
HUV60_RS09110	COG4166	transmembrane transport
HUV60_RS09130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUV60_RS09135	COG0509	glycine decarboxylation via glycine cleavage system
HUV60_RS09140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUV60_RS09145	COG1760	l-serine dehydratase
HUV60_RS09150	COG1278	Cold shock
HUV60_RS09205	COG1674	ftsk spoiiie
HUV60_RS09210	COG1404	Belongs to the peptidase S8 family
HUV60_RS09270	COG1132	(ABC) transporter
HUV60_RS09275	COG1132	(ABC) transporter
HUV60_RS09335	COG3281	Trehalose synthase
HUV60_RS09340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUV60_RS09360	COG3290	protein histidine kinase activity
HUV60_RS09365	COG4565	transcriptional regulatory protein
HUV60_RS09380	COG0205	6-phosphofructokinase activity
HUV60_RS09385	COG0280	phosphate acetyltransferase
HUV60_RS09385	COG0857	belongs to the CobB CobQ family
HUV60_RS09390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUV60_RS09425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS09425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS09485	COG2205	protein histidine kinase activity
HUV60_RS09490	COG0745	RESPONSE REGULATOR receiver
HUV60_RS09510	COG0183	Belongs to the thiolase family
HUV60_RS09530	COG1131	(ABC) transporter
HUV60_RS09565	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUV60_RS09580	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUV60_RS09610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUV60_RS09615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUV60_RS09620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUV60_RS09625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUV60_RS09630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUV60_RS09635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUV60_RS09640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUV60_RS09660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUV60_RS09665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUV60_RS09675	COG2890	protein-(glutamine-N5) methyltransferase activity
HUV60_RS09680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUV60_RS09685	COG0254	rRNA binding
HUV60_RS09700	COG0083	homoserine kinase activity
HUV60_RS09705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUV60_RS09710	COG0460	homoserine dehydrogenase
HUV60_RS09715	COG0019	diaminopimelate decarboxylase activity
HUV60_RS09720	COG0018	arginyl-trna synthetase
HUV60_RS09780	COG1011	Hydrolase
HUV60_RS09785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUV60_RS09810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUV60_RS09815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUV60_RS09830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUV60_RS09945	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS09950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUV60_RS09970	COG0577	efflux transmembrane transporter activity
HUV60_RS09970	COG1136	(ABC) transporter
HUV60_RS09985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUV60_RS10000	COG0515	serine threonine protein kinase
HUV60_RS10000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUV60_RS10005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUV60_RS10070	COG0210	DNA helicase
HUV60_RS10085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUV60_RS10095	COG1846	Transcriptional regulator
HUV60_RS10100	COG2409	Drug exporters of the RND superfamily
HUV60_RS10105	COG0702	epimerase
HUV60_RS10115	COG1802	Transcriptional regulator
HUV60_RS10140	COG1595	DNA-templated transcription, initiation
HUV60_RS10170	COG0768	penicillin binding
HUV60_RS10225	COG0642	Histidine kinase
HUV60_RS10240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUV60_RS10250	COG0745	RESPONSE REGULATOR receiver
HUV60_RS10255	COG2205	protein histidine kinase activity
HUV60_RS10260	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUV60_RS10260	COG0567	Dehydrogenase, E1 component
HUV60_RS10295	COG0604	alcohol dehydrogenase
HUV60_RS10300	COG0281	malic enzyme
HUV60_RS10315	COG1126	abc transporter atp-binding protein
HUV60_RS10320	COG4106	trans-aconitate 2-methyltransferase activity
HUV60_RS10360	COG0142	geranyltranstransferase activity
HUV60_RS10365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUV60_RS10385	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUV60_RS10405	COG1597	lipid kinase activity
HUV60_RS10420	COG0363	glucosamine-6-phosphate deaminase activity
HUV60_RS10425	COG2188	Transcriptional regulator
HUV60_RS10455	COG2124	cytochrome p450
HUV60_RS10465	COG0242	peptide deformylase activity
HUV60_RS10490	COG5662	AntiSigma factor
HUV60_RS10495	COG1595	DNA-templated transcription, initiation
HUV60_RS10505	COG2135	peptidase activity
HUV60_RS10520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUV60_RS10540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUV60_RS10560	COG0483	inositol monophosphate 1-phosphatase activity
HUV60_RS10570	COG0753	catalase activity
HUV60_RS10595	COG1615	UPF0182 protein
HUV60_RS10605	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUV60_RS10655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUV60_RS10685	COG2816	NAD+ diphosphatase activity
HUV60_RS10695	COG0210	DNA helicase
HUV60_RS10715	COG0596	Alpha beta hydrolase
HUV60_RS10745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUV60_RS10745	COG0596	Alpha beta hydrolase
HUV60_RS10785	COG1432	Conserved Protein
HUV60_RS10795	COG2095	MarC family integral membrane protein
HUV60_RS10815	COG0598	Magnesium transport protein CorA
HUV60_RS10850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUV60_RS10855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUV60_RS10865	COG1595	DNA-templated transcription, initiation
HUV60_RS10885	COG1024	Enoyl-CoA hydratase
HUV60_RS10890	COG0519	Catalyzes the synthesis of GMP from XMP
HUV60_RS10900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUV60_RS10910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUV60_RS10965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUV60_RS10970	COG0673	inositol 2-dehydrogenase activity
HUV60_RS10975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUV60_RS10980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUV60_RS10985	COG1073	alpha beta
HUV60_RS11035	COG0154	amidase activity
HUV60_RS11060	COG0488	(ABC) transporter
HUV60_RS11070	COG4608	Belongs to the ABC transporter superfamily
HUV60_RS11075	COG0444	Belongs to the ABC transporter superfamily
HUV60_RS11080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUV60_RS11085	COG0601	transmembrane transport
HUV60_RS11095	COG4608	Belongs to the ABC transporter superfamily
HUV60_RS11110	COG0747	negative chemotaxis
HUV60_RS11115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUV60_RS11120	COG1217	gtp-binding protein TYPA
HUV60_RS11140	COG1053	succinate dehydrogenase
HUV60_RS11145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUV60_RS11205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUV60_RS11230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUV60_RS11275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUV60_RS11350	COG0012	GTP binding
HUV60_RS11365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUV60_RS11370	COG1570	exodeoxyribonuclease VII activity
HUV60_RS11375	COG1722	exodeoxyribonuclease VII activity
HUV60_RS11385	COG0778	Nitroreductase
HUV60_RS11410	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUV60_RS11410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUV60_RS11420	COG0114	fumarate hydratase activity
HUV60_RS11425	COG3557	Belongs to the UPF0374 family
HUV60_RS11435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUV60_RS11455	COG1136	(ABC) transporter
HUV60_RS11465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUV60_RS11480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUV60_RS11485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUV60_RS11570	COG2197	response regulator
HUV60_RS11575	COG4585	Histidine kinase
HUV60_RS11605	COG2894	cell division
HUV60_RS11655	COG0251	oxidation-reduction process
HUV60_RS11660	COG1414	Transcriptional regulator
HUV60_RS11675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUV60_RS11685	COG0436	Aminotransferase
HUV60_RS11700	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUV60_RS11715	COG1331	Highly conserved protein containing a thioredoxin domain
HUV60_RS11730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUV60_RS11740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUV60_RS11745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUV60_RS11765	COG1136	(ABC) transporter
HUV60_RS11790	COG2986	histidine ammonia-lyase
HUV60_RS11800	COG1024	Enoyl-CoA hydratase
HUV60_RS11810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUV60_RS11820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUV60_RS11835	COG0424	maF-like protein
HUV60_RS11845	COG4770	biotin carboxylase activity
HUV60_RS11870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUV60_RS11880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUV60_RS11885	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS11890	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS11905	COG0515	serine threonine protein kinase
HUV60_RS11905	COG2815	serine threonine protein kinase
HUV60_RS11920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUV60_RS11970	COG4585	Histidine kinase
HUV60_RS12000	COG1595	DNA-templated transcription, initiation
HUV60_RS12005	COG0745	RESPONSE REGULATOR receiver
HUV60_RS12010	COG2205	protein histidine kinase activity
HUV60_RS12035	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUV60_RS12045	COG0583	DNA-binding transcription factor activity
HUV60_RS12050	COG2814	Major facilitator Superfamily
HUV60_RS12080	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUV60_RS12090	COG3845	ABC transporter
HUV60_RS12095	COG1744	ABC transporter substrate-binding protein PnrA-like
HUV60_RS12100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUV60_RS12105	COG1744	ABC transporter substrate-binding protein PnrA-like
HUV60_RS12110	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUV60_RS12110	COG1473	amidohydrolase
HUV60_RS12120	COG2089	acid synthase
HUV60_RS12135	COG1216	Glycosyl transferase, family 2
HUV60_RS12170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS12170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS12185	COG1595	DNA-templated transcription, initiation
HUV60_RS12220	COG2009	succinate dehydrogenase
HUV60_RS12230	COG1053	succinate dehydrogenase
HUV60_RS12260	COG1309	transcriptional regulator
HUV60_RS12305	COG1131	(ABC) transporter
HUV60_RS12370	COG1595	DNA-templated transcription, initiation
HUV60_RS12380	COG0745	RESPONSE REGULATOR receiver
HUV60_RS12390	COG1408	metallophosphoesterase
HUV60_RS12400	COG1686	Belongs to the peptidase S11 family
HUV60_RS12405	COG1295	ribonuclease BN
HUV60_RS12420	COG0180	Tryptophanyl-tRNA synthetase
HUV60_RS12425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUV60_RS12450	COG4176	ABC-type proline glycine betaine transport system permease component
HUV60_RS12455	COG0517	IMP dehydrogenase activity
HUV60_RS12455	COG4175	Glycine betaine
HUV60_RS12465	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS12485	COG0039	L-malate dehydrogenase activity
HUV60_RS12500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUV60_RS12515	COG0138	bifunctional purine biosynthesis protein purh
HUV60_RS12545	COG0045	succinate-CoA ligase (ADP-forming) activity
HUV60_RS12550	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUV60_RS12555	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HUV60_RS12560	COG0714	Associated with various cellular activities
HUV60_RS12575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS12575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUV60_RS12585	COG0739	heme binding
HUV60_RS12620	COG2197	response regulator
HUV60_RS12660	COG0519	Catalyzes the synthesis of GMP from XMP
HUV60_RS12660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUV60_RS12685	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS12700	COG2815	serine threonine protein kinase
HUV60_RS12700	COG0515	serine threonine protein kinase
HUV60_RS12710	COG0515	serine threonine protein kinase
HUV60_RS12710	COG2815	serine threonine protein kinase
HUV60_RS12725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUV60_RS12735	COG0516	GMP reductase activity
HUV60_RS12745	COG1595	DNA-templated transcription, initiation
HUV60_RS12750	COG2197	response regulator
HUV60_RS12760	COG0583	DNA-binding transcription factor activity
HUV60_RS12790	COG0459	protein refolding
HUV60_RS12795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUV60_RS12805	COG0726	polysaccharide deacetylase
HUV60_RS12820	COG1609	Transcriptional regulator
HUV60_RS12840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUV60_RS12865	COG0802	atpase or kinase
HUV60_RS12875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUV60_RS12895	COG0736	holo-[acyl-carrier-protein] synthase activity
HUV60_RS12910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUV60_RS12925	COG1072	(Pantothenic acid kinase))
HUV60_RS12930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUV60_RS12935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUV60_RS12940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUV60_RS12950	COG0101	tRNA pseudouridine synthase activity
HUV60_RS12960	COG0203	ribosomal protein L17
HUV60_RS12965	COG0202	RNA polymerase activity
HUV60_RS12970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUV60_RS12975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUV60_RS12980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUV60_RS12985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUV60_RS12995	COG0563	adenylate kinase activity
HUV60_RS13000	COG0201	protein transport
HUV60_RS13005	COG0200	Binds to the 23S rRNA
HUV60_RS13010	COG1841	ribosomal large subunit assembly
HUV60_RS13015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUV60_RS13020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUV60_RS13025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUV60_RS13030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUV60_RS13035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUV60_RS13040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUV60_RS13045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUV60_RS13050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUV60_RS13055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUV60_RS13060	COG0255	Belongs to the universal ribosomal protein uL29 family
HUV60_RS13065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUV60_RS13070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUV60_RS13075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUV60_RS13080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUV60_RS13085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUV60_RS13090	COG0089	rRNA binding
HUV60_RS13095	COG0088	Forms part of the polypeptide exit tunnel
HUV60_RS13100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUV60_RS13105	COG0051	transcription antitermination factor activity, RNA binding
HUV60_RS13115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUV60_RS13130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUV60_RS13135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUV60_RS13140	COG0049	tRNA binding
HUV60_RS13145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUV60_RS13155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUV60_RS13160	COG0085	RNA polymerase activity
HUV60_RS13165	COG0222	ribosome binding
HUV60_RS13170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUV60_RS13180	COG0081	regulation of translation
HUV60_RS13185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUV60_RS13190	COG0250	Participates in transcription elongation, termination and antitermination
HUV60_RS13205	COG0436	Aminotransferase
HUV60_RS13210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUV60_RS13215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUV60_RS13225	COG0477	Major facilitator Superfamily
HUV60_RS13240	COG2030	dehydratase
HUV60_RS13245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUV60_RS13280	COG1666	GTP binding
HUV60_RS13285	COG2261	transglycosylase associated protein
HUV60_RS13305	COG0501	Belongs to the peptidase M48B family
HUV60_RS13310	COG1007	ATP synthesis coupled electron transport
HUV60_RS13325	COG0713	ATP synthesis coupled electron transport
HUV60_RS13330	COG0839	Belongs to the complex I subunit 6 family
HUV60_RS13335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUV60_RS13340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUV60_RS13345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUV60_RS13350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUV60_RS13355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUV60_RS13375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUV60_RS13375	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUV60_RS13380	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUV60_RS13385	COG1733	regulation of RNA biosynthetic process
HUV60_RS13425	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUV60_RS13445	COG0142	geranyltranstransferase activity
HUV60_RS13450	COG3953	SLT domain
HUV60_RS13450	COG5412	phage tail tape measure protein
HUV60_RS13455	COG0561	phosphatase activity
HUV60_RS13515	COG1007	ATP synthesis coupled electron transport
HUV60_RS13525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUV60_RS13530	COG0713	ATP synthesis coupled electron transport
HUV60_RS13540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUV60_RS13545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUV60_RS13550	COG1034	ATP synthesis coupled electron transport
HUV60_RS13555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUV60_RS13565	COG0649	NAD binding
HUV60_RS13570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUV60_RS13575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUV60_RS13585	COG3103	Sh3 type 3 domain protein
HUV60_RS13585	COG1388	LysM domain
HUV60_RS13585	COG0791	NLP P60 protein
HUV60_RS13605	COG2226	methyltransferase
HUV60_RS13610	COG1073	alpha beta
HUV60_RS13630	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUV60_RS13650	COG3344	reverse transcriptase
HUV60_RS13780	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HUV60_RS13870	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUV60_RS13875	COG1278	Cold shock
HUV60_RS13910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUV60_RS13920	COG0163	prenyltransferase activity
HUV60_RS13930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUV60_RS13940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUV60_RS13955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUV60_RS13960	COG1333	cytochrome c biogenesis protein
HUV60_RS13965	COG0785	Cytochrome C biogenesis protein
HUV60_RS13970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUV60_RS13980	COG0406	alpha-ribazole phosphatase activity
HUV60_RS13985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUV60_RS14010	COG0673	inositol 2-dehydrogenase activity
HUV60_RS14025	COG3842	ATPase activity
HUV60_RS14040	COG1609	Transcriptional regulator
HUV60_RS14065	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUV60_RS14075	COG2340	Cysteine-rich secretory protein family
HUV60_RS14080	COG0642	Histidine kinase
HUV60_RS14080	COG3850	Histidine kinase
HUV60_RS14095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUV60_RS14100	COG1742	UPF0060 membrane protein
HUV60_RS14125	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUV60_RS14130	COG0018	arginyl-trna synthetase
HUV60_RS14175	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUV60_RS14205	COG3655	Transcriptional regulator
HUV60_RS14240	COG0113	porphobilinogen synthase activity
HUV60_RS14245	COG3973	AAA domain
HUV60_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS14280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUV60_RS14280	COG1648	precorrin-2 dehydrogenase activity
HUV60_RS14285	COG0181	hydroxymethylbilane synthase activity
HUV60_RS14290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUV60_RS14295	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUV60_RS14345	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUV60_RS14350	COG2223	nitrite transmembrane transporter activity
HUV60_RS14355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUV60_RS14385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUV60_RS14395	COG0842	Transport permease protein
HUV60_RS14395	COG1129	ABC transporter
HUV60_RS14405	COG4991	sh3 domain protein
HUV60_RS14410	COG0515	serine threonine protein kinase
HUV60_RS14410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUV60_RS14415	COG0129	dihydroxy-acid dehydratase activity
HUV60_RS14425	COG1082	Xylose isomerase domain protein TIM barrel
HUV60_RS14430	COG0248	Ppx GppA phosphatase
HUV60_RS14450	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUV60_RS14460	COG1194	a g-specific adenine glycosylase
HUV60_RS14465	COG1595	DNA-templated transcription, initiation
HUV60_RS14475	COG0745	RESPONSE REGULATOR receiver
HUV60_RS14480	COG2205	protein histidine kinase activity
HUV60_RS14485	COG0739	heme binding
HUV60_RS14510	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUV60_RS14530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUV60_RS14540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUV60_RS14545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUV60_RS14565	COG2197	response regulator
HUV60_RS14580	COG0649	NAD binding
HUV60_RS14610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUV60_RS14625	COG0302	gtp cyclohydrolase
HUV60_RS14635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HUV60_RS14640	COG0037	tRNA processing
HUV60_RS14650	COG2027	D-alanyl-D-alanine carboxypeptidase
HUV60_RS14655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUV60_RS14665	COG0586	Pfam SNARE associated Golgi protein
HUV60_RS14670	COG0393	Putative heavy-metal-binding
HUV60_RS14675	COG0789	Transcriptional regulator
HUV60_RS14680	COG0076	glutamate decarboxylase activity
HUV60_RS14700	COG2318	DinB family
HUV60_RS14705	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS14775	COG3344	reverse transcriptase
HUV60_RS14935	COG2801	Transposase and inactivated derivatives
HUV60_RS14975	COG1061	Type III restriction enzyme res subunit
HUV60_RS15110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUV60_RS15115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUV60_RS15115	COG1754	DNA topoisomerase type I activity
HUV60_RS15135	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUV60_RS15140	COG2172	sigma factor antagonist activity
HUV60_RS15145	COG1366	Belongs to the anti-sigma-factor antagonist family
HUV60_RS15150	COG1111	helicase
HUV60_RS15150	COG1205	dead DEAH box helicase
HUV60_RS15210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUV60_RS15215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUV60_RS15225	COG2267	carboxylic ester hydrolase activity
HUV60_RS15280	COG0003	Pfam Anion-transporting ATPase
HUV60_RS15300	COG1408	metallophosphoesterase
HUV60_RS15335	COG3629	intracellular signal transduction
HUV60_RS15335	COG3903	Transcriptional regulator
HUV60_RS15355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUV60_RS15425	COG2003	Belongs to the UPF0758 family
HUV60_RS15465	COG3344	reverse transcriptase
HUV60_RS15475	COG1609	Transcriptional regulator
HUV60_RS15650	COG3903	Transcriptional regulator
HUV60_RS15650	COG3629	intracellular signal transduction
HUV60_RS15690	COG0701	Predicted permease
HUV60_RS15715	COG1595	DNA-templated transcription, initiation
HUV60_RS15740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUV60_RS15745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUV60_RS15775	COG1802	Transcriptional regulator
HUV60_RS15795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUV60_RS15805	COG1846	Transcriptional regulator
HUV60_RS15810	COG1131	(ABC) transporter
HUV60_RS15815	COG3559	Exporter of polyketide antibiotics
HUV60_RS15825	COG2197	response regulator
HUV60_RS15830	COG4585	Histidine kinase
HUV60_RS15840	COG3844	kynureninase activity
HUV60_RS15845	COG3483	tryptophan 2,3-dioxygenase activity
HUV60_RS15865	COG0191	fructose-bisphosphate aldolase activity
HUV60_RS15870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUV60_RS15885	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUV60_RS15910	COG4115	mRNA cleavage
HUV60_RS15920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUV60_RS15945	COG0542	response to heat
HUV60_RS15975	COG4213	ABC transporter substrate-binding protein
HUV60_RS15980	COG0789	Transcriptional regulator
HUV60_RS15985	COG0484	heat shock protein binding
HUV60_RS15990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUV60_RS15995	COG0443	Heat shock 70 kDa protein
HUV60_RS16000	COG0247	lactate metabolic process
HUV60_RS16000	COG2181	nitrate reductase activity
HUV60_RS16025	COG0717	Belongs to the dCTP deaminase family
HUV60_RS16120	COG2188	Transcriptional regulator
HUV60_RS16155	COG3328	transposase activity
HUV60_RS16210	COG3594	Acyltransferase
HUV60_RS16225	COG1595	DNA-templated transcription, initiation
HUV60_RS16235	COG1733	regulation of RNA biosynthetic process
HUV60_RS16285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUV60_RS16320	COG1191	sigma factor activity
HUV60_RS16325	COG1191	sigma factor activity
HUV60_RS16345	COG3467	pyridoxamine 5'-phosphate
HUV60_RS16350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUV60_RS16360	COG2205	protein histidine kinase activity
HUV60_RS16365	COG0745	RESPONSE REGULATOR receiver
HUV60_RS16385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUV60_RS16400	COG0784	Response regulator, receiver
HUV60_RS16405	COG0318	PFAM AMP-dependent synthetase and ligase
HUV60_RS16410	COG1595	DNA-templated transcription, initiation
HUV60_RS16440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUV60_RS16455	COG0653	protein targeting
HUV60_RS16470	COG0006	proline dipeptidase activity
HUV60_RS16490	COG1999	signal sequence binding
HUV60_RS16505	COG2837	iron assimilation
HUV60_RS16515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUV60_RS16520	COG0561	phosphatase activity
HUV60_RS16550	COG1131	(ABC) transporter
HUV60_RS16575	COG0561	phosphatase activity
HUV60_RS16580	COG0739	heme binding
HUV60_RS16585	COG4988	ABC transporter
HUV60_RS16590	COG1294	oxidase, subunit
HUV60_RS16595	COG1271	oxidase subunit
HUV60_RS16600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUV60_RS16605	COG1609	Transcriptional regulator
HUV60_RS16625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUV60_RS16650	COG0662	Cupin 2, conserved barrel domain protein
HUV60_RS16655	COG1950	PFAM Membrane protein of
HUV60_RS16660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUV60_RS16665	COG0626	cystathionine gamma-synthase activity
HUV60_RS16775	COG3328	transposase activity
HUV60_RS16825	COG0305	Participates in initiation and elongation during chromosome replication
HUV60_RS16835	COG0359	binds to the 23S rRNA
HUV60_RS16840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUV60_RS16845	COG0629	single-stranded DNA binding
HUV60_RS16850	COG0360	Binds together with S18 to 16S ribosomal RNA
HUV60_RS16875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUV60_RS16885	COG1260	myo-inositol-1-phosphate synthase
HUV60_RS16900	COG0617	tRNA 3'-terminal CCA addition
HUV60_RS16915	COG2815	serine threonine protein kinase
HUV60_RS16915	COG0515	serine threonine protein kinase
HUV60_RS16920	COG1595	DNA-templated transcription, initiation
HUV60_RS16930	COG0492	ferredoxin-NADP+ reductase activity
HUV60_RS16935	COG3118	belongs to the thioredoxin family
HUV60_RS16950	COG1192	Involved in chromosome partitioning
HUV60_RS16955	COG0357	Ribosomal RNA small subunit methyltransferase G
HUV60_RS16965	COG0706	membrane insertase activity
HUV60_RS16970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUV60_RS16975	COG0594	ribonuclease P activity
HUV60_RS16980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUV60_RS16985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUV60_RS16990	COG0592	DNA-directed DNA polymerase activity
HUV60_RS16995	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUV60_RS17000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUV60_RS17005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUV60_RS17010	COG0187	DNA topoisomerase II activity
HUV60_RS17015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUV60_RS17045	COG0515	serine threonine protein kinase
HUV60_RS17070	COG0705	Rhomboid family
HUV60_RS17100	COG3764	Sortase (surface protein transpeptidase)
HUV60_RS17105	COG3764	Sortase (surface protein transpeptidase)
HUV60_RS17115	COG0515	serine threonine protein kinase
HUV60_RS17120	COG0768	penicillin binding
HUV60_RS17135	COG1716	ATPase activity
HUV60_RS17140	COG1716	ATPase activity
HUV60_RS17180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUV60_RS17185	COG2151	metal-sulfur cluster biosynthetic enzyme
HUV60_RS17190	COG3396	Phenylacetate-CoA oxygenase
HUV60_RS17195	COG3460	Phenylacetate-CoA oxygenase
HUV60_RS17200	COG3396	Phenylacetate-CoA oxygenase
HUV60_RS17225	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUV60_RS17235	COG1522	sequence-specific DNA binding
HUV60_RS17280	COG0604	alcohol dehydrogenase
HUV60_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS17280	COG3321	synthase
HUV60_RS17295	COG0515	serine threonine protein kinase
HUV60_RS17300	COG0515	serine threonine protein kinase
HUV60_RS17315	COG0022	dehydrogenase e1 component
HUV60_RS17320	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUV60_RS17370	COG1362	aminopeptidase activity
HUV60_RS17375	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS17385	COG1741	Belongs to the pirin family
HUV60_RS17395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUV60_RS17415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUV60_RS17495	COG1278	Cold shock
HUV60_RS17540	COG3903	Transcriptional regulator
HUV60_RS17540	COG3629	intracellular signal transduction
HUV60_RS17560	COG0513	Belongs to the DEAD box helicase family
HUV60_RS17565	COG1278	Cold shock
HUV60_RS17580	COG0640	Transcriptional regulator
HUV60_RS17600	COG0151	Belongs to the GarS family
HUV60_RS17615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUV60_RS17625	COG2197	response regulator
HUV60_RS17660	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUV60_RS17665	COG0047	phosphoribosylformylglycinamidine synthase activity
HUV60_RS17670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUV60_RS17700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUV60_RS17710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUV60_RS17735	COG1643	Atp-dependent helicase
HUV60_RS17770	COG0513	Belongs to the DEAD box helicase family
HUV60_RS17800	COG2197	response regulator
HUV60_RS17805	COG0475	glutathione-regulated potassium exporter activity
HUV60_RS17810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUV60_RS17810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUV60_RS17830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUV60_RS17835	COG0579	oxidoreductase
HUV60_RS17860	COG1252	NADH dehydrogenase
HUV60_RS17910	COG4221	oxidoreductase activity
HUV60_RS18000	COG1196	nuclear chromosome segregation
HUV60_RS18000	COG0741	lytic transglycosylase activity
HUV60_RS18000	COG0739	heme binding
HUV60_RS18005	COG0671	phosphoesterase, PA-phosphatase related
HUV60_RS18025	COG1937	Protein conserved in bacteria
HUV60_RS18035	COG0306	phosphate transporter
HUV60_RS18040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUV60_RS18060	COG0494	nUDIX hydrolase
HUV60_RS18060	COG0406	alpha-ribazole phosphatase activity
HUV60_RS18070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUV60_RS18080	COG1131	(ABC) transporter
HUV60_RS18085	COG0456	acetyltransferase
HUV60_RS18090	COG4085	toxin activity
HUV60_RS18090	COG1525	nuclease
HUV60_RS18090	COG0737	Belongs to the 5'-nucleotidase family
HUV60_RS18125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUV60_RS18130	COG1609	Transcriptional regulator
HUV60_RS18135	COG0745	RESPONSE REGULATOR receiver
HUV60_RS18160	COG2897	thiosulfate sulfurtransferase activity
HUV60_RS18185	COG3485	protocatechuate 3,4-dioxygenase
HUV60_RS18195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUV60_RS18200	COG1490	D-aminoacyl-tRNA deacylase activity
HUV60_RS18210	COG4552	Acetyltransferase involved in intracellular survival and related
HUV60_RS18215	COG2188	Transcriptional regulator
HUV60_RS18225	COG2188	Transcriptional regulator
HUV60_RS18230	COG3344	reverse transcriptase
HUV60_RS18270	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS18295	COG1295	ribonuclease BN
HUV60_RS18325	COG0588	phosphoglycerate mutase activity
HUV60_RS18345	COG5002	protein histidine kinase activity
HUV60_RS18360	COG1329	Transcriptional regulator
HUV60_RS18365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUV60_RS18370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUV60_RS18375	COG0215	cysteine-tRNA ligase activity
HUV60_RS18400	COG3842	ATPase activity
HUV60_RS18405	COG2378	regulation of single-species biofilm formation
HUV60_RS18495	COG2801	Transposase and inactivated derivatives
HUV60_RS18525	COG1295	ribonuclease BN
HUV60_RS18570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUV60_RS18595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUV60_RS18625	COG0463	Glycosyl transferase, family 2
HUV60_RS18640	COG1278	Cold shock
HUV60_RS18645	COG0459	protein refolding
HUV60_RS18665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUV60_RS18670	COG1737	Transcriptional regulator
HUV60_RS18705	COG3973	AAA domain
HUV60_RS18720	COG1061	Type III restriction enzyme res subunit
HUV60_RS18790	COG3385	transposase activity
HUV60_RS18800	COG1278	Cold shock
HUV60_RS18805	COG2197	response regulator
HUV60_RS18810	COG4585	Histidine kinase
HUV60_RS18820	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUV60_RS18825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUV60_RS18835	COG2814	Major facilitator Superfamily
HUV60_RS18850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUV60_RS18850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUV60_RS18860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUV60_RS18870	COG2252	PERMEase
HUV60_RS18900	COG0667	Aldo Keto reductase
HUV60_RS18935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUV60_RS18940	COG0667	Aldo Keto reductase
HUV60_RS18970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUV60_RS18990	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUV60_RS19000	COG2124	cytochrome p450
HUV60_RS19025	COG0277	FAD linked oxidase domain protein
HUV60_RS19025	COG0247	lactate metabolic process
HUV60_RS19060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUV60_RS19075	COG0318	PFAM AMP-dependent synthetase and ligase
HUV60_RS19090	COG0259	pyridoxamine-phosphate oxidase activity
HUV60_RS19105	COG4821	SIS domain
HUV60_RS19115	COG2945	thiolester hydrolase activity
HUV60_RS19115	COG0596	Alpha beta hydrolase
HUV60_RS19180	COG0259	pyridoxamine-phosphate oxidase activity
HUV60_RS19200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUV60_RS19200	COG0515	serine threonine protein kinase
HUV60_RS19220	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUV60_RS19250	COG1686	Belongs to the peptidase S11 family
HUV60_RS19275	COG0386	Belongs to the glutathione peroxidase family
HUV60_RS19320	COG0513	Belongs to the DEAD box helicase family
HUV60_RS19325	COG1278	Cold shock
HUV60_RS19350	COG3594	Acyltransferase
HUV60_RS19400	COG4974	Belongs to the 'phage' integrase family
HUV60_RS19410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUV60_RS19475	COG1011	Hydrolase
HUV60_RS19590	COG1846	Transcriptional regulator
HUV60_RS19595	COG3384	dioxygenase
HUV60_RS19615	COG1349	DNA-binding transcription factor activity
HUV60_RS19625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUV60_RS19625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUV60_RS19625	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HUV60_RS19640	COG3191	aminopeptidase activity
HUV60_RS19650	COG1970	mechanosensitive ion channel activity
HUV60_RS19660	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUV60_RS19685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUV60_RS19690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUV60_RS19700	COG0315	cyclic pyranopterin monophosphate synthase activity
HUV60_RS19705	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUV60_RS19705	COG0315	cyclic pyranopterin monophosphate synthase activity
HUV60_RS19710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUV60_RS19780	COG2801	Transposase and inactivated derivatives
HUV60_RS19810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUV60_RS19825	COG2072	flavoprotein involved in K transport
HUV60_RS19830	COG2267	carboxylic ester hydrolase activity
HUV60_RS19835	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS19845	COG0793	Belongs to the peptidase S41A family
HUV60_RS19845	COG4946	Tricorn protease homolog
HUV60_RS19855	COG2409	Drug exporters of the RND superfamily
HUV60_RS19865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUV60_RS19880	COG0768	penicillin binding
HUV60_RS19900	COG0084	hydrolase, TatD family'
HUV60_RS19905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUV60_RS19910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUV60_RS19925	COG0488	(ABC) transporter
HUV60_RS19965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUV60_RS19980	COG2197	response regulator
HUV60_RS19985	COG1846	Transcriptional regulator
HUV60_RS19995	COG1309	transcriptional regulator
HUV60_RS20005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUV60_RS20020	COG1196	nuclear chromosome segregation
HUV60_RS20125	COG1201	RNA secondary structure unwinding
HUV60_RS20130	COG0193	aminoacyl-tRNA hydrolase activity
HUV60_RS20135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUV60_RS20140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUV60_RS20145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUV60_RS20150	COG4585	Histidine kinase
HUV60_RS20175	COG1136	(ABC) transporter
HUV60_RS20180	COG0577	efflux transmembrane transporter activity
HUV60_RS20225	COG2815	serine threonine protein kinase
HUV60_RS20225	COG0515	serine threonine protein kinase
HUV60_RS20255	COG0148	phosphopyruvate hydratase activity
HUV60_RS20275	COG1252	NADH dehydrogenase
HUV60_RS20280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUV60_RS20285	COG0577	efflux transmembrane transporter activity
HUV60_RS20290	COG1136	(ABC) transporter
HUV60_RS20325	COG0183	Belongs to the thiolase family
HUV60_RS20330	COG2755	lipolytic protein G-D-S-L family
HUV60_RS20360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUV60_RS20365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUV60_RS20375	COG1228	amidohydrolase
HUV60_RS20380	COG1191	sigma factor activity
HUV60_RS20385	COG1366	Belongs to the anti-sigma-factor antagonist family
HUV60_RS20400	COG3104	oligopeptide transport
HUV60_RS20405	COG0745	RESPONSE REGULATOR receiver
HUV60_RS20410	COG2205	protein histidine kinase activity
HUV60_RS20425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUV60_RS20435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUV60_RS20460	COG1316	TRANSCRIPTIONal
HUV60_RS20475	COG1316	TRANSCRIPTIONal
HUV60_RS20480	COG1316	TRANSCRIPTIONal
HUV60_RS20485	COG1316	TRANSCRIPTIONal
HUV60_RS20510	COG0778	Nitroreductase
HUV60_RS20510	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUV60_RS20515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUV60_RS20550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUV60_RS20555	COG2835	tetraacyldisaccharide 4'-kinase activity
HUV60_RS20565	COG1482	cell wall glycoprotein biosynthetic process
HUV60_RS20575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUV60_RS20615	COG0714	Associated with various cellular activities
HUV60_RS20640	COG0745	RESPONSE REGULATOR receiver
HUV60_RS20645	COG5002	protein histidine kinase activity
HUV60_RS20645	COG5000	phosphorelay sensor kinase activity
HUV60_RS20650	COG0823	Involved in the tonB-independent uptake of proteins
HUV60_RS20660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUV60_RS20665	COG2197	response regulator
HUV60_RS20670	COG3214	Protein conserved in bacteria
HUV60_RS20680	COG0653	protein targeting
HUV60_RS20700	COG2902	Dehydrogenase
HUV60_RS20705	COG1134	teichoic acid transport
HUV60_RS20725	COG1846	Transcriptional regulator
HUV60_RS20730	COG1764	response to oxidative stress
HUV60_RS20735	COG0395	ABC-type sugar transport system, permease component
HUV60_RS20740	COG1175	transmembrane transport
HUV60_RS20745	COG1653	transport
HUV60_RS20760	COG0515	serine threonine protein kinase
HUV60_RS20765	COG0515	serine threonine protein kinase
HUV60_RS20770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUV60_RS20790	COG2884	Cell division ATP-binding protein ftsE
HUV60_RS20800	COG0793	Belongs to the peptidase S41A family
HUV60_RS20805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUV60_RS20815	COG1609	Transcriptional regulator
HUV60_RS20850	COG2223	nitrite transmembrane transporter activity
HUV60_RS20875	COG3973	AAA domain
HUV60_RS20885	COG0776	regulation of translation
HUV60_RS20890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUV60_RS20895	COG1678	Uncharacterized ACR, COG1678
HUV60_RS20920	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUV60_RS20935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUV60_RS20955	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUV60_RS20965	COG1174	glycine betaine transport
HUV60_RS20975	COG1174	glycine betaine transport
HUV60_RS20985	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUV60_RS20995	COG0277	FAD linked oxidase domain protein
HUV60_RS21030	COG1335	isochorismatase
HUV60_RS21040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUV60_RS21050	COG1115	amino acid carrier protein
HUV60_RS21050	COG1115	amino acid carrier protein
HUV60_RS21075	COG1234	tRNA 3'-trailer cleavage
HUV60_RS21080	COG1263	PTS System
HUV60_RS21085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUV60_RS21090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUV60_RS21100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUV60_RS21130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUV60_RS21145	COG4555	ABC transporter
HUV60_RS21160	COG2733	membrane
HUV60_RS21175	COG2132	Multicopper oxidase
HUV60_RS21280	COG0706	membrane insertase activity
HUV60_RS21290	COG4702	Belongs to the UPF0303 family
HUV60_RS21295	COG0673	inositol 2-dehydrogenase activity
HUV60_RS21300	COG1940	carbohydrate kinase activity
HUV60_RS21360	COG1126	abc transporter atp-binding protein
HUV60_RS21365	COG0765	amino acid transport
HUV60_RS21370	COG0765	amino acid transport
HUV60_RS21375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUV60_RS21390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUV60_RS21405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUV60_RS21455	COG0406	alpha-ribazole phosphatase activity
HUV60_RS21480	COG0745	RESPONSE REGULATOR receiver
HUV60_RS21495	COG0395	ABC-type sugar transport system, permease component
HUV60_RS21520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUV60_RS21525	COG4977	sequence-specific DNA binding
HUV60_RS21530	COG0589	response to stress
HUV60_RS21535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUV60_RS21595	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUV60_RS21615	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS21630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUV60_RS21635	COG1309	transcriptional regulator
HUV60_RS21645	COG1946	Acyl-CoA thioesterase
HUV60_RS21660	COG0028	Belongs to the TPP enzyme family
HUV60_RS21675	COG0346	lactoylglutathione lyase activity
HUV60_RS21710	COG2356	endonuclease I
HUV60_RS21730	COG1472	Belongs to the glycosyl hydrolase 3 family
HUV60_RS21735	COG0583	DNA-binding transcription factor activity
HUV60_RS21760	COG0673	inositol 2-dehydrogenase activity
HUV60_RS21785	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUV60_RS21795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUV60_RS21805	COG0151	Belongs to the GarS family
HUV60_RS21820	COG0151	Belongs to the GarS family
HUV60_RS21835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUV60_RS21840	COG0318	PFAM AMP-dependent synthetase and ligase
HUV60_RS21845	COG0287	Prephenate dehydrogenase
HUV60_RS21850	COG0512	Glutamine amidotransferase of anthranilate synthase
HUV60_RS21850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUV60_RS21855	COG1605	Chorismate mutase
HUV60_RS21860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS21865	COG1942	4-Oxalocrotonate Tautomerase
HUV60_RS21870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUV60_RS21875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUV60_RS21900	COG1869	D-ribose catabolic process
HUV60_RS21905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUV60_RS21915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUV60_RS21935	COG1131	(ABC) transporter
HUV60_RS21960	COG0492	ferredoxin-NADP+ reductase activity
HUV60_RS21980	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS21990	COG0728	peptidoglycan biosynthetic process
HUV60_RS22000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUV60_RS22030	COG2304	oxidoreductase activity
HUV60_RS22085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS22085	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HUV60_RS22105	COG2188	Transcriptional regulator
HUV60_RS22120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUV60_RS22130	COG0629	single-stranded DNA binding
HUV60_RS22165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUV60_RS22215	COG1486	melibiose metabolic process
HUV60_RS22220	COG0668	transmembrane transport
HUV60_RS22320	COG0582	viral genome integration into host DNA
HUV60_RS22450	COG3210	domain, Protein
HUV60_RS22460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUV60_RS22505	COG2188	Transcriptional regulator
HUV60_RS22515	COG1674	ftsk spoiiie
HUV60_RS22530	COG4974	Belongs to the 'phage' integrase family
HUV60_RS22540	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HUV60_RS22570	COG1846	Transcriptional regulator
HUV60_RS22575	COG0697	spore germination
HUV60_RS22640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUV60_RS22705	COG0740	serine-type endopeptidase activity
HUV60_RS22710	COG0740	serine-type endopeptidase activity
HUV60_RS22715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUV60_RS22725	COG0525	valine-tRNA ligase activity
HUV60_RS22730	COG0285	dihydrofolate synthase activity
HUV60_RS22740	COG0105	UTP biosynthetic process
HUV60_RS22745	COG1077	Cell shape determining protein MreB Mrl
HUV60_RS22760	COG0768	penicillin binding
HUV60_RS22765	COG0772	Belongs to the SEDS family
HUV60_RS22805	COG0539	negative regulation of cytoplasmic translation
HUV60_RS22835	COG2186	Transcriptional regulator
HUV60_RS22905	COG1530	ribonuclease E activity
HUV60_RS22915	COG0753	catalase activity
HUV60_RS22925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUV60_RS22930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUV60_RS22935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUV60_RS22960	COG1215	transferase activity, transferring glycosyl groups
HUV60_RS22975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUV60_RS22985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUV60_RS23000	COG0501	Belongs to the peptidase M48B family
HUV60_RS23010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUV60_RS23020	COG0799	negative regulation of ribosome biogenesis
HUV60_RS23025	COG0588	phosphoglycerate mutase activity
HUV60_RS23045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUV60_RS23055	COG0495	leucyl-tRNA aminoacylation
HUV60_RS23065	COG1307	EDD domain protein, DegV family
HUV60_RS23070	COG1555	photosystem II stabilization
HUV60_RS23070	COG1596	polysaccharide export
HUV60_RS23075	COG1234	tRNA 3'-trailer cleavage
HUV60_RS23095	COG0268	Binds directly to 16S ribosomal RNA
HUV60_RS23100	COG0481	GTPase activity
HUV60_RS23110	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HUV60_RS23125	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUV60_RS23130	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUV60_RS23170	COG1819	glycosyl
HUV60_RS23195	COG1420	regulation of RNA biosynthetic process
HUV60_RS23200	COG0484	heat shock protein binding
HUV60_RS23225	COG0793	Belongs to the peptidase S41A family
HUV60_RS23225	COG4946	Tricorn protease homolog
HUV60_RS23230	COG0537	adenosine 5'-monophosphoramidase activity
HUV60_RS23235	COG1234	tRNA 3'-trailer cleavage
HUV60_RS23240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUV60_RS23245	COG4948	Mandelate Racemase Muconate Lactonizing
HUV60_RS23260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUV60_RS23270	COG2315	Protein conserved in bacteria
HUV60_RS23285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUV60_RS23290	COG2723	6-phospho-beta-galactosidase activity
HUV60_RS23305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUV60_RS23370	COG1381	Involved in DNA repair and RecF pathway recombination
HUV60_RS23375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUV60_RS23385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUV60_RS23390	COG1121	(ABC) transporter
HUV60_RS23395	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUV60_RS23395	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUV60_RS23400	COG0423	glycine-tRNA ligase activity
HUV60_RS23425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUV60_RS23425	COG0574	Belongs to the PEP-utilizing enzyme family
HUV60_RS23455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUV60_RS23455	COG2146	nitrite reductase [NAD(P)H] activity
HUV60_RS23460	COG2146	nitrite reductase [NAD(P)H] activity
HUV60_RS23460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUV60_RS23480	COG1733	regulation of RNA biosynthetic process
HUV60_RS23495	COG0243	molybdopterin cofactor binding
HUV60_RS23510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUV60_RS23520	COG0358	DNA primase activity
HUV60_RS23525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUV60_RS23565	COG1070	Carbohydrate kinase
HUV60_RS23690	COG3654	unkown
HUV60_RS23805	COG1077	Cell shape determining protein MreB Mrl
HUV60_RS23810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUV60_RS23810	COG0825	malonyl-CoA metabolic process
HUV60_RS23815	COG0318	PFAM AMP-dependent synthetase and ligase
HUV60_RS23850	COG4981	capsule polysaccharide biosynthetic process
HUV60_RS23880	COG1414	Transcriptional regulator
HUV60_RS23885	COG3386	PFAM SMP-30 Gluconolaconase
HUV60_RS24000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUV60_RS24010	COG4214	carbohydrate transport
HUV60_RS24015	COG1129	ABC transporter
HUV60_RS24045	COG2130	NADP-dependent
HUV60_RS24070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUV60_RS24075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUV60_RS24080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUV60_RS24165	COG0789	Transcriptional regulator
HUV60_RS24170	COG0667	Aldo Keto reductase
HUV60_RS24185	COG1309	transcriptional regulator
HUV60_RS24190	COG0477	Major facilitator Superfamily
HUV60_RS24200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUV60_RS24250	COG1358	cellular component organization or biogenesis
HUV60_RS24260	COG0586	Pfam SNARE associated Golgi protein
HUV60_RS24320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUV60_RS24360	COG4122	O-methyltransferase activity
HUV60_RS24380	COG3845	ABC transporter
HUV60_RS24395	COG1657	PFAM Prenyltransferase squalene oxidase
HUV60_RS24405	COG1309	transcriptional regulator
HUV60_RS24410	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS24440	COG4221	oxidoreductase activity
HUV60_RS24465	COG0477	Major facilitator Superfamily
HUV60_RS24485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUV60_RS24500	COG0800	Aldolase
HUV60_RS24505	COG3022	response to hydroperoxide
HUV60_RS24565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUV60_RS24570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUV60_RS24590	COG2259	Doxx family
HUV60_RS24600	COG2814	Major facilitator Superfamily
HUV60_RS24605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUV60_RS24695	COG1994	Peptidase M50
HUV60_RS24715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUV60_RS24725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUV60_RS24725	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUV60_RS24730	COG1959	2 iron, 2 sulfur cluster binding
HUV60_RS24735	COG1017	nitric oxide dioxygenase activity
HUV60_RS24735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUV60_RS24740	COG0174	glutamine synthetase
HUV60_RS24760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUV60_RS24770	COG0784	Response regulator, receiver
HUV60_RS24775	COG4251	negative regulation of phosphorylation
HUV60_RS24785	COG1609	Transcriptional regulator
HUV60_RS24790	COG1653	transport
HUV60_RS24795	COG1175	transmembrane transport
HUV60_RS24800	COG3833	ABC-type maltose transport systems, permease component
HUV60_RS24805	COG0366	Alpha amylase catalytic
HUV60_RS24825	COG1309	transcriptional regulator
HUV60_RS24880	COG0174	glutamine synthetase
HUV60_RS24900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUV60_RS24905	COG0321	lipoyl(octanoyl) transferase activity
HUV60_RS24925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUV60_RS24945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUV60_RS24955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUV60_RS24960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUV60_RS24965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUV60_RS24975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUV60_RS24985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUV60_RS25005	COG2226	methyltransferase
HUV60_RS25025	COG4585	Histidine kinase
HUV60_RS25030	COG2197	response regulator
HUV60_RS25035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUV60_RS25045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUV60_RS25065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUV60_RS25080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUV60_RS25085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUV60_RS25095	COG1376	ErfK ybiS ycfS ynhG family protein
HUV60_RS25105	COG1845	cytochrome c oxidase, subunit III
HUV60_RS25110	COG2010	Cytochrome c
HUV60_RS25115	COG0723	plastoquinol--plastocyanin reductase activity
HUV60_RS25120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUV60_RS25125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUV60_RS25130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUV60_RS25140	COG0705	Rhomboid family
HUV60_RS25155	COG0791	NLP P60 protein
HUV60_RS25155	COG3103	Sh3 type 3 domain protein
HUV60_RS25155	COG1388	LysM domain
HUV60_RS25160	COG0791	NLP P60 protein
HUV60_RS25160	COG3883	PFAM NLP P60 protein
HUV60_RS25175	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS25180	COG1022	Amp-dependent synthetase and ligase
HUV60_RS25195	COG0003	Pfam Anion-transporting ATPase
HUV60_RS25205	COG1940	carbohydrate kinase activity
HUV60_RS25240	COG4585	Histidine kinase
HUV60_RS25245	COG2197	response regulator
HUV60_RS25250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUV60_RS25260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUV60_RS25270	COG2193	ferroxidase activity
HUV60_RS25275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUV60_RS25280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUV60_RS25285	COG2815	serine threonine protein kinase
HUV60_RS25285	COG0515	serine threonine protein kinase
HUV60_RS25290	COG2022	thiamine diphosphate biosynthetic process
HUV60_RS25310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUV60_RS25320	COG0352	thiamine-phosphate diphosphorylase activity
HUV60_RS25335	COG1233	COG1233 Phytoene dehydrogenase and related
HUV60_RS25345	COG1309	transcriptional regulator
HUV60_RS25355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUV60_RS25375	COG0714	Associated with various cellular activities
HUV60_RS25385	COG0275	rRNA processing
HUV60_RS25400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUV60_RS25410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUV60_RS25415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUV60_RS25425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUV60_RS25430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUV60_RS25435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUV60_RS25440	COG1496	oxidoreductase activity
HUV60_RS25450	COG1799	cell septum assembly
HUV60_RS25460	COG3599	regulation of cell shape
HUV60_RS25465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUV60_RS25475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUV60_RS25555	COG0587	DNA-directed DNA polymerase activity
HUV60_RS25565	COG1432	Conserved Protein
HUV60_RS25610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUV60_RS25615	COG0131	Imidazoleglycerol-phosphate dehydratase
HUV60_RS25625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUV60_RS25630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUV60_RS25635	COG0251	oxidation-reduction process
HUV60_RS25640	COG0107	imidazoleglycerol-phosphate synthase activity
HUV60_RS25655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUV60_RS25680	COG0134	indole-3-glycerol-phosphate synthase activity
HUV60_RS25690	COG0133	tryptophan synthase activity
HUV60_RS25695	COG0159	tryptophan synthase activity
HUV60_RS25705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUV60_RS25730	COG1397	ADP-ribosylglycohydrolase
HUV60_RS25740	COG0070	glutamate synthase
HUV60_RS25740	COG0069	glutamate synthase activity
HUV60_RS25740	COG0067	glutamate synthase
HUV60_RS25770	COG1605	Chorismate mutase
HUV60_RS25770	COG0287	Prephenate dehydrogenase
HUV60_RS25780	COG0737	Belongs to the 5'-nucleotidase family
HUV60_RS25840	COG2050	protein possibly involved in aromatic compounds catabolism
HUV60_RS25865	COG1643	Atp-dependent helicase
HUV60_RS25870	COG2226	methyltransferase
HUV60_RS25885	COG0237	dephospho-CoA kinase activity
HUV60_RS25900	COG4106	trans-aconitate 2-methyltransferase activity
HUV60_RS25915	COG2267	carboxylic ester hydrolase activity
HUV60_RS25925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUV60_RS25995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUV60_RS25995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUV60_RS26000	COG2313	pseudouridylate synthase activity
HUV60_RS26010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUV60_RS26015	COG0584	glycerophosphoryl diester phosphodiesterase
HUV60_RS26025	COG0556	nucleotide-excision repair
HUV60_RS26050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUV60_RS26065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUV60_RS26075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUV60_RS26080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUV60_RS26090	COG0723	plastoquinol--plastocyanin reductase activity
HUV60_RS26110	COG0322	excinuclease ABC activity
HUV60_RS26115	COG1660	Displays ATPase and GTPase activities
HUV60_RS26120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUV60_RS26125	COG1481	regulation of sporulation
HUV60_RS26130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUV60_RS26135	COG0126	phosphoglycerate kinase activity
HUV60_RS26140	COG0149	triose-phosphate isomerase activity
HUV60_RS26145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUV60_RS26155	COG0166	Belongs to the GPI family
HUV60_RS26170	COG0363	glucosamine-6-phosphate deaminase activity
HUV60_RS26185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUV60_RS26195	COG0109	protoheme IX farnesyltransferase activity
HUV60_RS26215	COG1612	heme a metabolic process
HUV60_RS26225	COG1131	(ABC) transporter
HUV60_RS26245	COG0719	Fe-S assembly protein
HUV60_RS26255	COG0396	ATPase activity
HUV60_RS26260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUV60_RS26265	COG0822	iron-sulfur transferase activity
HUV60_RS26270	COG2151	metal-sulfur cluster biosynthetic enzyme
HUV60_RS26280	COG3226	Transcriptional regulator
HUV60_RS26290	COG2171	N-acyltransferase activity
HUV60_RS26295	COG1595	DNA-templated transcription, initiation
HUV60_RS26355	COG1063	alcohol dehydrogenase
HUV60_RS26360	COG0395	ABC-type sugar transport system, permease component
HUV60_RS26375	COG1349	DNA-binding transcription factor activity
HUV60_RS26380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUV60_RS26385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUV60_RS26400	COG1802	Transcriptional regulator
HUV60_RS26420	COG0395	ABC-type sugar transport system, permease component
HUV60_RS26445	COG2755	lipolytic protein G-D-S-L family
HUV60_RS26450	COG3866	Pectate lyase
HUV60_RS26475	COG1595	DNA-templated transcription, initiation
HUV60_RS26480	COG2252	PERMEase
HUV60_RS26495	COG1414	Transcriptional regulator
HUV60_RS26520	COG3844	kynureninase activity
HUV60_RS26525	COG5285	phytanoyl-CoA dioxygenase
HUV60_RS26530	COG1917	Cupin 2, conserved barrel domain protein
HUV60_RS26535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUV60_RS26540	COG0456	acetyltransferase
HUV60_RS26545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUV60_RS26555	COG0765	amino acid transport
HUV60_RS26575	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HUV60_RS26590	COG2241	protein methyltransferase activity
HUV60_RS26590	COG2242	protein methyltransferase activity
HUV60_RS26605	COG1797	cobyrinic acid a,c-diamide synthase activity
HUV60_RS26625	COG1492	cobalamin metabolic process
HUV60_RS26630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUV60_RS26645	COG0235	Class ii aldolase
HUV60_RS26665	COG0488	(ABC) transporter
HUV60_RS26710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUV60_RS26715	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUV60_RS26725	COG1129	ABC transporter
HUV60_RS26735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUV60_RS26750	COG3387	PFAM Glycoside hydrolase 15-related
HUV60_RS26775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUV60_RS26805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUV60_RS26810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUV60_RS26830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUV60_RS26865	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS26880	COG2186	Transcriptional regulator
HUV60_RS26895	COG0588	phosphoglycerate mutase activity
HUV60_RS26900	COG0560	Phosphoserine phosphatase
HUV60_RS26900	COG3830	Belongs to the UPF0237 family
HUV60_RS26910	COG0842	Transport permease protein
HUV60_RS26910	COG1131	(ABC) transporter
HUV60_RS26910	COG1716	ATPase activity
HUV60_RS26925	COG2197	response regulator
HUV60_RS26940	COG1119	ATPase activity
HUV60_RS26960	COG1881	PFAM PEBP family protein
HUV60_RS27015	COG0647	UMP catabolic process
HUV60_RS27020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUV60_RS27025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUV60_RS27030	COG1120	ATPase activity
HUV60_RS27050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUV60_RS27055	COG0497	DNA recombination
HUV60_RS27065	COG3387	PFAM Glycoside hydrolase 15-related
HUV60_RS27070	COG0504	CTP synthase activity
HUV60_RS27075	COG0494	nUDIX hydrolase
HUV60_RS27085	COG0686	Belongs to the AlaDH PNT family
HUV60_RS27100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUV60_RS27105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUV60_RS27110	COG1187	pseudouridine synthase activity
HUV60_RS27115	COG0494	nUDIX hydrolase
HUV60_RS27145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUV60_RS27155	COG1160	GTP binding
HUV60_RS27185	COG0671	phosphoesterase, PA-phosphatase related
HUV60_RS27195	COG0477	Major facilitator Superfamily
HUV60_RS27200	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS27205	COG1799	cell septum assembly
HUV60_RS27245	COG1725	Transcriptional regulator
HUV60_RS27255	COG0726	polysaccharide deacetylase
HUV60_RS27270	COG2755	lipolytic protein G-D-S-L family
HUV60_RS27275	COG0515	serine threonine protein kinase
HUV60_RS27275	COG2815	serine threonine protein kinase
HUV60_RS27295	COG1595	DNA-templated transcription, initiation
HUV60_RS27315	COG2188	Transcriptional regulator
HUV60_RS27320	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUV60_RS27335	COG0243	molybdopterin cofactor binding
HUV60_RS27365	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS27395	COG3876	Protein conserved in bacteria
HUV60_RS27410	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS27430	COG2149	membrane
HUV60_RS27435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUV60_RS27465	COG3265	gluconokinase activity
HUV60_RS27470	COG2186	Transcriptional regulator
HUV60_RS27480	COG3012	SEC-C Motif Domain Protein
HUV60_RS27515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUV60_RS27545	COG0667	Aldo Keto reductase
HUV60_RS27550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUV60_RS27560	COG0598	Magnesium transport protein CorA
HUV60_RS27565	COG0406	alpha-ribazole phosphatase activity
HUV60_RS27580	COG0215	cysteine-tRNA ligase activity
HUV60_RS27595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUV60_RS27600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUV60_RS27605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUV60_RS27610	COG1414	Transcriptional regulator
HUV60_RS27615	COG0646	methionine synthase
HUV60_RS27615	COG1410	methionine synthase
HUV60_RS27625	COG4166	transmembrane transport
HUV60_RS27630	COG2197	response regulator
HUV60_RS27640	COG1994	Peptidase M50
HUV60_RS27640	COG0517	IMP dehydrogenase activity
HUV60_RS27660	COG1222	aaa ATPase
HUV60_RS27665	COG4122	O-methyltransferase activity
HUV60_RS27680	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUV60_RS27685	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUV60_RS27690	COG1609	Transcriptional regulator
HUV60_RS27700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUV60_RS27705	COG0545	Peptidyl-prolyl cis-trans isomerase
HUV60_RS27715	COG2378	regulation of single-species biofilm formation
HUV60_RS27735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUV60_RS27740	COG0805	protein transport
HUV60_RS27775	COG0564	pseudouridine synthase activity
HUV60_RS27790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUV60_RS27800	COG0517	IMP dehydrogenase activity
HUV60_RS27800	COG4175	Glycine betaine
HUV60_RS27805	COG4176	ABC-type proline glycine betaine transport system permease component
HUV60_RS27825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUV60_RS27830	COG0531	amino acid
HUV60_RS27840	COG0174	glutamine synthetase
HUV60_RS27845	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS27850	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS27890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUV60_RS27895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUV60_RS27900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUV60_RS27905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUV60_RS27910	COG5002	protein histidine kinase activity
HUV60_RS27915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUV60_RS27920	COG0072	phenylalanine-tRNA ligase activity
HUV60_RS27920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUV60_RS27955	COG0475	glutathione-regulated potassium exporter activity
HUV60_RS27980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS27980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS27985	COG3251	PFAM MbtH domain protein
HUV60_RS28005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUV60_RS28020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUV60_RS28030	COG0644	oxidoreductase
HUV60_RS28035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUV60_RS28045	COG0592	DNA-directed DNA polymerase activity
HUV60_RS28060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS28065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS28070	COG0066	3-isopropylmalate dehydratase activity
HUV60_RS28075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUV60_RS28080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUV60_RS28145	COG1649	PFAM Uncharacterised BCR, COG1649
HUV60_RS28155	COG0697	spore germination
HUV60_RS28190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUV60_RS28195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUV60_RS28200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUV60_RS28205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUV60_RS28210	COG1438	arginine binding
HUV60_RS28225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUV60_RS28225	COG1017	nitric oxide dioxygenase activity
HUV60_RS28240	COG0137	argininosuccinate synthase activity
HUV60_RS28245	COG0165	Argininosuccinate lyase
HUV60_RS28255	COG0204	Acyl-transferase
HUV60_RS28255	COG0318	PFAM AMP-dependent synthetase and ligase
HUV60_RS28260	COG0584	glycerophosphoryl diester phosphodiesterase
HUV60_RS28285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUV60_RS28295	COG2011	ABC-type metal ion transport system permease component
HUV60_RS28300	COG1464	Belongs to the NlpA lipoprotein family
HUV60_RS28315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUV60_RS28320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUV60_RS28320	COG1648	precorrin-2 dehydrogenase activity
HUV60_RS28380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUV60_RS28380	COG0512	Glutamine amidotransferase of anthranilate synthase
HUV60_RS28435	COG1175	transmembrane transport
HUV60_RS28440	COG0395	ABC-type sugar transport system, permease component
HUV60_RS28480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUV60_RS28500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUV60_RS28505	COG1560	Kdo2-lipid A biosynthetic process
HUV60_RS28510	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS28520	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUV60_RS28525	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUV60_RS28530	COG0217	transcriptional regulatory protein
HUV60_RS28535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUV60_RS28540	COG0632	four-way junction helicase activity
HUV60_RS28545	COG2255	four-way junction helicase activity
HUV60_RS28555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUV60_RS28560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUV60_RS28565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUV60_RS28570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUV60_RS28575	COG1196	nuclear chromosome segregation
HUV60_RS28580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUV60_RS28590	COG0124	histidyl-tRNA synthetase
HUV60_RS28690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUV60_RS28705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUV60_RS28710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUV60_RS28720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUV60_RS28735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUV60_RS28740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUV60_RS28745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUV60_RS28755	COG0006	proline dipeptidase activity
HUV60_RS28760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUV60_RS28765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUV60_RS28780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUV60_RS28785	COG0540	Belongs to the ATCase OTCase family
HUV60_RS28790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUV60_RS28800	COG0505	Belongs to the CarA family
HUV60_RS28805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUV60_RS28810	COG0167	dihydroorotate dehydrogenase activity
HUV60_RS28815	COG0284	orotidine-5'-phosphate decarboxylase activity
HUV60_RS28825	COG0194	GDP metabolic process
HUV60_RS28830	COG1758	RNA polymerase activity
HUV60_RS28840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUV60_RS28855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUV60_RS28870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUV60_RS28875	COG2390	Transcriptional regulator
HUV60_RS28900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUV60_RS28905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUV60_RS28925	COG0738	Major facilitator superfamily
HUV60_RS28930	COG1846	Transcriptional regulator
HUV60_RS28930	COG1940	carbohydrate kinase activity
HUV60_RS28945	COG3201	nicotinamide mononucleotide transporter
HUV60_RS28950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUV60_RS28950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUV60_RS28955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUV60_RS28960	COG0140	phosphoribosyl-ATP diphosphatase activity
HUV60_RS28965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUV60_RS29005	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS29025	COG1216	Glycosyl transferase, family 2
HUV60_RS29030	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUV60_RS29040	COG2270	Major facilitator Superfamily
HUV60_RS29045	COG0584	glycerophosphoryl diester phosphodiesterase
HUV60_RS29055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUV60_RS29085	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS29125	COG2018	Roadblock/LC7 domain
HUV60_RS29145	COG1122	ATPase activity
HUV60_RS29170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUV60_RS29180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUV60_RS29210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUV60_RS29230	COG1716	ATPase activity
HUV60_RS29250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUV60_RS29260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUV60_RS29260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUV60_RS29275	COG1175	transmembrane transport
HUV60_RS29280	COG0395	ABC-type sugar transport system, permease component
HUV60_RS29355	COG0723	plastoquinol--plastocyanin reductase activity
HUV60_RS29385	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS29395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUV60_RS29410	COG2318	DinB family
HUV60_RS29435	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUV60_RS29445	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS29495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUV60_RS29500	COG3321	synthase
HUV60_RS29500	COG0604	alcohol dehydrogenase
HUV60_RS29520	COG1309	transcriptional regulator
HUV60_RS29555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUV60_RS29565	COG3321	synthase
HUV60_RS29565	COG0604	alcohol dehydrogenase
HUV60_RS29575	COG0318	PFAM AMP-dependent synthetase and ligase
HUV60_RS29590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUV60_RS29595	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUV60_RS29610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUV60_RS29615	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUV60_RS29620	COG3321	synthase
HUV60_RS29620	COG0604	alcohol dehydrogenase
HUV60_RS29665	COG2124	cytochrome p450
HUV60_RS29690	COG1090	epimerase
HUV60_RS29700	COG1819	glycosyl
HUV60_RS29755	COG2161	toxin-antitoxin pair type II binding
HUV60_RS29825	COG4191	Histidine kinase
HUV60_RS29825	COG2205	protein histidine kinase activity
HUV60_RS29825	COG0745	RESPONSE REGULATOR receiver
HUV60_RS29840	COG0154	amidase activity
HUV60_RS29860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUV60_RS29925	COG1968	undecaprenyl-diphosphatase activity
HUV60_RS29935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUV60_RS29940	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUV60_RS29945	COG0582	viral genome integration into host DNA
HUV60_RS29960	COG5433	transposase activity
HUV60_RS29985	COG5433	transposase activity
HUV60_RS30055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUV60_RS30085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUV60_RS30130	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUV60_RS30140	COG0110	maltose O-acetyltransferase activity
HUV60_RS30155	COG0640	Transcriptional regulator
HUV60_RS30165	COG1832	CoA-binding protein
HUV60_RS30180	COG1739	Uncharacterized protein family UPF0029
HUV60_RS30185	COG0420	3'-5' exonuclease activity
HUV60_RS30190	COG0419	ATPase involved in DNA repair
HUV60_RS30205	COG0626	cystathionine gamma-synthase activity
HUV60_RS30220	COG2267	carboxylic ester hydrolase activity
HUV60_RS30230	COG2188	Transcriptional regulator
HUV60_RS30235	COG1940	carbohydrate kinase activity
HUV60_RS30255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUV60_RS30280	COG0577	efflux transmembrane transporter activity
HUV60_RS30280	COG1136	(ABC) transporter
HUV60_RS30285	COG0577	efflux transmembrane transporter activity
HUV60_RS30285	COG1136	(ABC) transporter
HUV60_RS30300	COG2226	methyltransferase
HUV60_RS30305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUV60_RS30310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUV60_RS30315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUV60_RS30360	COG0204	Acyl-transferase
HUV60_RS30375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUV60_RS30380	COG1834	amidinotransferase
HUV60_RS30385	COG1522	sequence-specific DNA binding
HUV60_RS30390	COG3279	Response regulator of the LytR AlgR family
HUV60_RS30400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUV60_RS30405	COG3275	phosphorelay sensor kinase activity
HUV60_RS30425	COG0205	6-phosphofructokinase activity
HUV60_RS30430	COG3442	glutamine amidotransferase
HUV60_RS30435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUV60_RS30440	COG0242	peptide deformylase activity
HUV60_RS30450	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS30465	COG1012	belongs to the aldehyde dehydrogenase family
HUV60_RS30480	COG0492	ferredoxin-NADP+ reductase activity
HUV60_RS30495	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS30500	COG1960	acyl-CoA dehydrogenase activity
HUV60_RS30570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUV60_RS30595	COG2018	Roadblock/LC7 domain
HUV60_RS30605	COG1946	Acyl-CoA thioesterase
HUV60_RS30620	COG0254	rRNA binding
HUV60_RS30635	COG3118	belongs to the thioredoxin family
HUV60_RS30640	COG0492	ferredoxin-NADP+ reductase activity
HUV60_RS30645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUV60_RS30650	COG0640	Transcriptional regulator
HUV60_RS30655	COG0798	PFAM Bile acid sodium symporter
HUV60_RS30665	COG2072	flavoprotein involved in K transport
HUV60_RS30670	COG1132	(ABC) transporter
HUV60_RS30675	COG1132	(ABC) transporter
HUV60_RS30685	COG1132	(ABC) transporter
HUV60_RS30690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUV60_RS30695	COG2072	flavoprotein involved in K transport
HUV60_RS30700	COG0432	Pfam Uncharacterised protein family UPF0047
HUV60_RS30715	COG0589	response to stress
HUV60_RS30800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUV60_RS30815	COG0583	DNA-binding transcription factor activity
HUV60_RS30820	COG0667	Aldo Keto reductase
HUV60_RS30855	COG0671	phosphoesterase, PA-phosphatase related
HUV60_RS30885	COG0584	glycerophosphoryl diester phosphodiesterase
HUV60_RS30910	COG0204	Acyl-transferase
HUV60_RS30925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUV60_RS30965	COG1660	Displays ATPase and GTPase activities
HUV60_RS30975	COG0445	tRNA wobble uridine modification
HUV60_RS31030	COG0673	inositol 2-dehydrogenase activity
HUV60_RS31070	COG2813	Specifically methylates the guanine in position
HUV60_RS31080	COG1940	carbohydrate kinase activity
HUV60_RS31090	COG3467	pyridoxamine 5'-phosphate
HUV60_RS31115	COG1349	DNA-binding transcription factor activity
HUV60_RS31130	COG0633	Ferredoxin
HUV60_RS31130	COG3217	Mosc domain protein beta barrel domain protein
HUV60_RS31145	COG1215	transferase activity, transferring glycosyl groups
HUV60_RS31205	COG2814	Major facilitator Superfamily
HUV60_RS31220	COG0667	Aldo Keto reductase
HUV60_RS31245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUV60_RS31250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUV60_RS31315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUV60_RS31320	COG1993	acr, cog1993
HUV60_RS31325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUV60_RS31340	COG1686	Belongs to the peptidase S11 family
HUV60_RS31360	COG2188	Transcriptional regulator
HUV60_RS31365	COG3458	cephalosporin-C deacetylase activity
HUV60_RS31375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUV60_RS31380	COG2890	protein-(glutamine-N5) methyltransferase activity
HUV60_RS31395	COG1902	pentaerythritol trinitrate reductase activity
HUV60_RS31395	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUV60_RS31425	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HUV60_RS31430	COG1461	Dihydroxyacetone kinase
HUV60_RS31435	COG2376	Dihydroxyacetone kinase
HUV60_RS31450	COG0701	Predicted permease
HUV60_RS31500	COG1063	alcohol dehydrogenase
HUV60_RS31505	COG1063	alcohol dehydrogenase
HUV60_RS31510	COG1937	Protein conserved in bacteria
HUV60_RS31560	COG0248	Ppx GppA phosphatase
HUV60_RS31565	COG0783	Belongs to the Dps family
HUV60_RS31610	COG2226	methyltransferase
HUV60_RS31635	COG0142	geranyltranstransferase activity
HUV60_RS31640	COG0384	phenazine biosynthesis protein PhzF
HUV60_RS31670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUV60_RS31755	COG0346	lactoylglutathione lyase activity
HUV60_RS31770	COG0583	DNA-binding transcription factor activity
HUV60_RS31775	COG0667	Aldo Keto reductase
HUV60_RS31810	COG1191	sigma factor activity
HUV60_RS31820	COG0740	serine-type endopeptidase activity
HUV60_RS31825	COG0740	serine-type endopeptidase activity
HUV60_RS31840	COG0328	RNA-DNA hybrid ribonuclease activity
HUV60_RS31845	COG0667	Aldo Keto reductase
HUV60_RS31870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUV60_RS31900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUV60_RS31995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUV60_RS32050	COG0181	hydroxymethylbilane synthase activity
HUV60_RS32075	COG0656	L-ascorbic acid biosynthetic process
HUV60_RS32090	COG0009	L-threonylcarbamoyladenylate synthase
HUV60_RS32100	COG0753	catalase activity
HUV60_RS32115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUV60_RS32145	COG2409	Drug exporters of the RND superfamily
HUV60_RS32245	COG0596	Alpha beta hydrolase
HUV60_RS32255	COG0438	transferase activity, transferring glycosyl groups
HUV60_RS32275	COG1175	transmembrane transport
HUV60_RS32300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUV60_RS32340	COG0277	FAD linked oxidase domain protein
HUV60_RS32345	COG1597	lipid kinase activity
HUV60_RS32375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUV60_RS32430	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUV60_RS32550	COG0395	ABC-type sugar transport system, permease component
HUV60_RS32660	COG3344	reverse transcriptase
HUV60_RS32680	COG0831	urea catabolic process
HUV60_RS32680	COG0832	Belongs to the urease beta subunit family
HUV60_RS32685	COG0804	urea catabolic process
HUV60_RS32700	COG0829	nickel cation binding
HUV60_RS32730	COG2963	transposase activity
HUV60_RS32760	COG4941	Belongs to the sigma-70 factor family
HUV60_RS32765	COG3795	YCII-related domain
HUV60_RS32915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUV60_RS32925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUV60_RS32965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUV60_RS33085	COG3344	reverse transcriptase
HUV60_RS33115	COG0024	Methionine aminopeptidase
HUV60_RS33140	COG1192	Involved in chromosome partitioning
HUV60_RS33170	COG1028	Short-chain dehydrogenase reductase Sdr
HUV60_RS33200	COG3629	intracellular signal transduction
HUV60_RS33200	COG3903	Transcriptional regulator
HUV60_RS33225	COG0247	lactate metabolic process
HUV60_RS33225	COG2181	nitrate reductase activity
HUV60_RS33255	COG0778	Nitroreductase
HUV60_RS33285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUV60_RS33300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUV60_RS33310	COG3424	synthase
HUV60_RS33320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUV60_RS33375	COG3425	synthase
HUV60_RS33385	COG0142	geranyltranstransferase activity
HUV60_RS33405	COG1595	DNA-templated transcription, initiation
HUV60_RS33410	COG1090	epimerase
HUV60_RS33440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUV60_RS33450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG