locus-tag	class	description
D1J63_RS00145	COG4585	Histidine kinase
D1J63_RS00150	COG2197	response regulator
D1J63_RS00195	COG2223	nitrite transmembrane transporter activity
D1J63_RS00200	COG2207	Transcriptional regulator
D1J63_RS00210	COG3655	Transcriptional regulator
D1J63_RS00215	COG0644	oxidoreductase
D1J63_RS00260	COG1819	glycosyl
D1J63_RS00265	COG0789	Transcriptional regulator
D1J63_RS00270	COG1051	belongs to the nudix hydrolase family
D1J63_RS00320	COG0243	molybdopterin cofactor binding
D1J63_RS00350	COG0542	response to heat
D1J63_RS00375	COG0483	inositol monophosphate 1-phosphatase activity
D1J63_RS00385	COG3226	Transcriptional regulator
D1J63_RS00390	COG0738	Major facilitator superfamily
D1J63_RS00410	COG0583	DNA-binding transcription factor activity
D1J63_RS00430	COG0583	DNA-binding transcription factor activity
D1J63_RS00450	COG0477	Major facilitator Superfamily
D1J63_RS00455	COG0531	amino acid
D1J63_RS00485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1J63_RS00495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1J63_RS00500	COG3387	PFAM Glycoside hydrolase 15-related
D1J63_RS00505	COG0589	response to stress
D1J63_RS00510	COG0129	dihydroxy-acid dehydratase activity
D1J63_RS00520	COG1278	Cold shock
D1J63_RS00530	COG1132	(ABC) transporter
D1J63_RS00550	COG0753	catalase activity
D1J63_RS00560	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1J63_RS00575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1J63_RS00630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1J63_RS00645	COG4310	Domain of unknown function (DUF2172)
D1J63_RS00655	COG1215	transferase activity, transferring glycosyl groups
D1J63_RS00665	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D1J63_RS00670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1J63_RS00700	COG2226	methyltransferase
D1J63_RS00705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1J63_RS00725	COG1595	DNA-templated transcription, initiation
D1J63_RS00745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J63_RS00755	COG3321	synthase
D1J63_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS00755	COG0604	alcohol dehydrogenase
D1J63_RS00760	COG0460	homoserine dehydrogenase
D1J63_RS00790	COG0667	Aldo Keto reductase
D1J63_RS00815	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D1J63_RS00830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D1J63_RS00840	COG1984	allophanate hydrolase subunit 2
D1J63_RS00870	COG0477	Major facilitator Superfamily
D1J63_RS00890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1J63_RS00900	COG1175	transmembrane transport
D1J63_RS00905	COG0395	ABC-type sugar transport system, permease component
D1J63_RS00910	COG1609	Transcriptional regulator
D1J63_RS00920	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J63_RS00940	COG3290	protein histidine kinase activity
D1J63_RS00950	COG0346	lactoylglutathione lyase activity
D1J63_RS00955	COG0789	Transcriptional regulator
D1J63_RS00960	COG0659	secondary active sulfate transmembrane transporter activity
D1J63_RS00970	COG0483	inositol monophosphate 1-phosphatase activity
D1J63_RS01000	COG2382	esterase
D1J63_RS01005	COG1132	(ABC) transporter
D1J63_RS01015	COG1132	(ABC) transporter
D1J63_RS01025	COG1120	ATPase activity
D1J63_RS01030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J63_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J63_RS01040	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1J63_RS01055	COG2936	dipeptidyl-peptidase activity
D1J63_RS01065	COG0513	Belongs to the DEAD box helicase family
D1J63_RS01075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1J63_RS01080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1J63_RS01090	COG0666	response to abiotic stimulus
D1J63_RS01140	COG1140	nitrate reductase beta subunit
D1J63_RS01150	COG2181	nitrate reductase activity
D1J63_RS01170	COG1278	Cold shock
D1J63_RS01180	COG0673	inositol 2-dehydrogenase activity
D1J63_RS01185	COG2188	Transcriptional regulator
D1J63_RS01220	COG0395	ABC-type sugar transport system, permease component
D1J63_RS01225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J63_RS01240	COG0739	heme binding
D1J63_RS01260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D1J63_RS01270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J63_RS01275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS01280	COG2340	Cysteine-rich secretory protein family
D1J63_RS01285	COG2205	protein histidine kinase activity
D1J63_RS01290	COG0745	RESPONSE REGULATOR receiver
D1J63_RS01320	COG0789	Transcriptional regulator
D1J63_RS01340	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1J63_RS01365	COG0142	geranyltranstransferase activity
D1J63_RS01370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1J63_RS01375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1J63_RS01380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1J63_RS01385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J63_RS01390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D1J63_RS01405	COG3340	Belongs to the peptidase S51 family
D1J63_RS01410	COG2124	cytochrome p450
D1J63_RS01430	COG2018	Roadblock/LC7 domain
D1J63_RS01455	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1J63_RS01460	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1J63_RS01465	COG0783	Belongs to the Dps family
D1J63_RS01485	COG1191	sigma factor activity
D1J63_RS01490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D1J63_RS01515	COG0505	Belongs to the CarA family
D1J63_RS01555	COG2235	arginine
D1J63_RS01575	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D1J63_RS01590	COG1937	Protein conserved in bacteria
D1J63_RS01595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1J63_RS01630	COG1233	COG1233 Phytoene dehydrogenase and related
D1J63_RS01635	COG1609	Transcriptional regulator
D1J63_RS01650	COG1595	DNA-templated transcription, initiation
D1J63_RS01665	COG0488	(ABC) transporter
D1J63_RS01675	COG1120	ATPase activity
D1J63_RS01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J63_RS01710	COG3397	chitin binding
D1J63_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS01735	COG2264	protein methyltransferase activity
D1J63_RS01800	COG1175	transmembrane transport
D1J63_RS01805	COG0395	ABC-type sugar transport system, permease component
D1J63_RS01810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1J63_RS01835	COG0277	FAD linked oxidase domain protein
D1J63_RS01875	COG3290	protein histidine kinase activity
D1J63_RS01895	COG0477	Major facilitator Superfamily
D1J63_RS01925	COG1295	ribonuclease BN
D1J63_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS01945	COG2080	2 iron, 2 sulfur cluster binding
D1J63_RS01950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1J63_RS01955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J63_RS02000	COG1132	(ABC) transporter
D1J63_RS02050	COG0410	ABC transporter
D1J63_RS02055	COG2508	Transcriptional regulator
D1J63_RS02060	COG2197	response regulator
D1J63_RS02070	COG0673	inositol 2-dehydrogenase activity
D1J63_RS02145	COG1309	transcriptional regulator
D1J63_RS02175	COG1846	Transcriptional regulator
D1J63_RS02175	COG1940	carbohydrate kinase activity
D1J63_RS02180	COG1175	transmembrane transport
D1J63_RS02185	COG0395	ABC-type sugar transport system, permease component
D1J63_RS02225	COG1132	(ABC) transporter
D1J63_RS02270	COG0517	IMP dehydrogenase activity
D1J63_RS02300	COG2274	protein secretion by the type I secretion system
D1J63_RS02305	COG0248	Ppx GppA phosphatase
D1J63_RS02320	COG2890	protein-(glutamine-N5) methyltransferase activity
D1J63_RS02335	COG1304	FMN binding
D1J63_RS02350	COG3250	beta-galactosidase activity
D1J63_RS02365	COG0667	Aldo Keto reductase
D1J63_RS02380	COG2124	cytochrome p450
D1J63_RS02395	COG0435	Glutathione S-transferase
D1J63_RS02425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1J63_RS02440	COG1007	ATP synthesis coupled electron transport
D1J63_RS02485	COG1796	DNA polymerase
D1J63_RS02485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D1J63_RS02530	COG2706	6-phosphogluconolactonase activity
D1J63_RS02550	COG1357	PFAM Pentapeptide repeats (8 copies)
D1J63_RS02555	COG1595	DNA-templated transcription, initiation
D1J63_RS02570	COG1609	Transcriptional regulator
D1J63_RS02590	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1J63_RS02595	COG1129	ABC transporter
D1J63_RS02600	COG4952	isomerase
D1J63_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS02605	COG3347	Dehydrogenase
D1J63_RS02610	COG1070	Carbohydrate kinase
D1J63_RS02615	COG0247	lactate metabolic process
D1J63_RS02620	COG1139	Iron-sulfur cluster binding protein
D1J63_RS02625	COG1556	Lactate utilization protein
D1J63_RS02630	COG1136	(ABC) transporter
D1J63_RS02630	COG0577	efflux transmembrane transporter activity
D1J63_RS02665	COG3540	Alkaline phosphatase
D1J63_RS02705	COG0668	transmembrane transport
D1J63_RS02720	COG2409	Drug exporters of the RND superfamily
D1J63_RS02725	COG1846	Transcriptional regulator
D1J63_RS02730	COG0702	epimerase
D1J63_RS02760	COG0604	alcohol dehydrogenase
D1J63_RS02775	COG1070	Carbohydrate kinase
D1J63_RS02790	COG1175	transmembrane transport
D1J63_RS02795	COG0395	ABC-type sugar transport system, permease component
D1J63_RS02800	COG1609	Transcriptional regulator
D1J63_RS02820	COG0800	Aldolase
D1J63_RS02835	COG0657	acetylesterase activity
D1J63_RS02870	COG0242	peptide deformylase activity
D1J63_RS02875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1J63_RS02880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1J63_RS02885	COG1609	Transcriptional regulator
D1J63_RS02900	COG0583	DNA-binding transcription factor activity
D1J63_RS02920	COG3976	FMN-binding domain protein
D1J63_RS02920	COG1053	succinate dehydrogenase
D1J63_RS02925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1J63_RS02935	COG0517	IMP dehydrogenase activity
D1J63_RS02950	COG0596	Alpha beta hydrolase
D1J63_RS02965	COG3467	pyridoxamine 5'-phosphate
D1J63_RS02985	COG3572	ergothioneine biosynthetic process
D1J63_RS02990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1J63_RS02995	COG0121	glutamine amidotransferase
D1J63_RS03000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D1J63_RS03005	COG2182	Extracellular solute-binding protein
D1J63_RS03010	COG3360	Dodecin
D1J63_RS03020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J63_RS03045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1J63_RS03050	COG1053	succinate dehydrogenase
D1J63_RS03060	COG0583	DNA-binding transcription factor activity
D1J63_RS03070	COG0583	DNA-binding transcription factor activity
D1J63_RS03115	COG0726	polysaccharide deacetylase
D1J63_RS03125	COG0531	amino acid
D1J63_RS03160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1J63_RS03185	COG0395	ABC-type sugar transport system, permease component
D1J63_RS03190	COG1175	transmembrane transport
D1J63_RS03200	COG1609	Transcriptional regulator
D1J63_RS03235	COG3537	Alpha-1,2-mannosidase
D1J63_RS03245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1J63_RS03250	COG0297	glycogen (starch) synthase activity
D1J63_RS03270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1J63_RS03295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1J63_RS03410	COG0574	Belongs to the PEP-utilizing enzyme family
D1J63_RS03410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1J63_RS03420	COG1063	alcohol dehydrogenase
D1J63_RS03430	COG0589	response to stress
D1J63_RS03460	COG0745	RESPONSE REGULATOR receiver
D1J63_RS03465	COG2205	protein histidine kinase activity
D1J63_RS03485	COG0702	epimerase
D1J63_RS03500	COG0142	geranyltranstransferase activity
D1J63_RS03520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D1J63_RS03555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1J63_RS03570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1J63_RS03575	COG0569	domain protein
D1J63_RS03765	COG4585	Histidine kinase
D1J63_RS03770	COG2201	protein-glutamate methylesterase activity
D1J63_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS03825	COG1169	isochorismate synthase
D1J63_RS03830	COG1132	(ABC) transporter
D1J63_RS03835	COG2375	cellular response to nickel ion
D1J63_RS03835	COG1132	(ABC) transporter
D1J63_RS03840	COG4106	trans-aconitate 2-methyltransferase activity
D1J63_RS03845	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D1J63_RS03850	COG2124	cytochrome p450
D1J63_RS03865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J63_RS03865	COG3433	isochorismatase activity
D1J63_RS03865	COG2226	methyltransferase
D1J63_RS03870	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D1J63_RS03870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J63_RS03875	COG1021	2,3-dihydroxybenzoate-AMP ligase
D1J63_RS03880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1J63_RS03885	COG4171	peptide transport system, permease
D1J63_RS03890	COG0601	transmembrane transport
D1J63_RS03915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1J63_RS03920	COG1120	ATPase activity
D1J63_RS03930	COG1609	Transcriptional regulator
D1J63_RS03945	COG2233	PERMEase
D1J63_RS03990	COG0366	Alpha amylase catalytic
D1J63_RS03990	COG1874	Beta-galactosidase
D1J63_RS04015	COG1653	transport
D1J63_RS04020	COG1175	transmembrane transport
D1J63_RS04025	COG0395	ABC-type sugar transport system, permease component
D1J63_RS04030	COG0366	Alpha amylase catalytic
D1J63_RS04040	COG1132	(ABC) transporter
D1J63_RS04060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1J63_RS04070	COG0531	amino acid
D1J63_RS04075	COG0668	transmembrane transport
D1J63_RS04080	COG2838	Isocitrate dehydrogenase
D1J63_RS04095	COG2124	cytochrome p450
D1J63_RS04110	COG1404	Belongs to the peptidase S8 family
D1J63_RS04120	COG2197	response regulator
D1J63_RS04135	COG0385	Bile acid
D1J63_RS04140	COG0673	inositol 2-dehydrogenase activity
D1J63_RS04145	COG0702	epimerase
D1J63_RS04150	COG3631	Ketosteroid isomerase-related protein
D1J63_RS04160	COG1609	Transcriptional regulator
D1J63_RS04170	COG0673	inositol 2-dehydrogenase activity
D1J63_RS04175	COG2764	glyoxalase bleomycin resistance protein dioxygenase
D1J63_RS04200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J63_RS04210	COG3718	enzyme involved in inositol metabolism
D1J63_RS04215	COG3962	Belongs to the TPP enzyme family
D1J63_RS04220	COG2188	Transcriptional regulator
D1J63_RS04270	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS04275	COG0183	Belongs to the thiolase family
D1J63_RS04280	COG2267	carboxylic ester hydrolase activity
D1J63_RS04305	COG0174	glutamine synthetase
D1J63_RS04320	COG1320	monovalent cation:proton antiporter activity
D1J63_RS04335	COG0651	ATP synthesis coupled electron transport
D1J63_RS04340	COG1006	Multisubunit Na H antiporter MnhC subunit
D1J63_RS04345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1J63_RS04345	COG2111	Na H antiporter
D1J63_RS04375	COG0583	DNA-binding transcription factor activity
D1J63_RS04380	COG0156	8-amino-7-oxononanoate synthase activity
D1J63_RS04385	COG1063	alcohol dehydrogenase
D1J63_RS04430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J63_RS04445	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1J63_RS04460	COG0662	Cupin 2, conserved barrel domain protein
D1J63_RS04475	COG2755	lipolytic protein G-D-S-L family
D1J63_RS04485	COG2365	Tyrosine phosphatase family
D1J63_RS04505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1J63_RS04510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1J63_RS04525	COG1657	PFAM Prenyltransferase squalene oxidase
D1J63_RS04535	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1J63_RS04550	COG1562	ergosterol biosynthetic process
D1J63_RS04555	COG1134	teichoic acid transport
D1J63_RS04600	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1J63_RS04610	COG1024	Enoyl-CoA hydratase
D1J63_RS04630	COG2183	response to ionizing radiation
D1J63_RS04635	COG0488	(ABC) transporter
D1J63_RS04645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1J63_RS04660	COG1113	amino acid transport
D1J63_RS04670	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J63_RS04670	COG1024	Enoyl-CoA hydratase
D1J63_RS04675	COG0183	Belongs to the thiolase family
D1J63_RS04680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J63_RS04685	COG3268	Saccharopine dehydrogenase
D1J63_RS04700	COG1515	deoxyribonuclease V activity
D1J63_RS04730	COG0488	(ABC) transporter
D1J63_RS04735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1J63_RS04740	COG1834	amidinotransferase
D1J63_RS04785	COG1793	dna ligase
D1J63_RS04795	COG1470	cell adhesion involved in biofilm formation
D1J63_RS04815	COG0183	Belongs to the thiolase family
D1J63_RS04820	COG3485	protocatechuate 3,4-dioxygenase
D1J63_RS04825	COG3485	protocatechuate 3,4-dioxygenase
D1J63_RS04830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1J63_RS04835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J63_RS04865	COG3511	phospholipase C
D1J63_RS04870	COG0477	Major facilitator Superfamily
D1J63_RS04885	COG2197	response regulator
D1J63_RS04890	COG1132	(ABC) transporter
D1J63_RS04895	COG1132	(ABC) transporter
D1J63_RS04905	COG0515	serine threonine protein kinase
D1J63_RS04945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1J63_RS04955	COG1486	melibiose metabolic process
D1J63_RS04970	COG2197	response regulator
D1J63_RS04975	COG2409	Drug exporters of the RND superfamily
D1J63_RS04995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1J63_RS05010	COG0166	Belongs to the GPI family
D1J63_RS05015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1J63_RS05030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1J63_RS05050	COG0297	glycogen (starch) synthase activity
D1J63_RS05070	COG1183	phosphatidylcholine synthase activity
D1J63_RS05085	COG0747	negative chemotaxis
D1J63_RS05145	COG2815	serine threonine protein kinase
D1J63_RS05145	COG0515	serine threonine protein kinase
D1J63_RS05150	COG0210	DNA helicase
D1J63_RS05175	COG0300	oxidoreductase activity
D1J63_RS05205	COG3340	Belongs to the peptidase S51 family
D1J63_RS05230	COG1733	regulation of RNA biosynthetic process
D1J63_RS05255	COG1733	regulation of RNA biosynthetic process
D1J63_RS05270	COG5434	Belongs to the glycosyl hydrolase 28 family
D1J63_RS05270	COG4632	Exopolysaccharide biosynthesis protein
D1J63_RS05290	COG2723	6-phospho-beta-galactosidase activity
D1J63_RS05295	COG0395	ABC-type sugar transport system, permease component
D1J63_RS05300	COG1175	transmembrane transport
D1J63_RS05305	COG2182	Extracellular solute-binding protein
D1J63_RS05310	COG1940	carbohydrate kinase activity
D1J63_RS05350	COG0129	dihydroxy-acid dehydratase activity
D1J63_RS05360	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J63_RS05370	COG1175	transmembrane transport
D1J63_RS05380	COG1609	Transcriptional regulator
D1J63_RS05390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1J63_RS05405	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS05415	COG0045	succinate-CoA ligase (ADP-forming) activity
D1J63_RS05425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J63_RS05435	COG2223	nitrite transmembrane transporter activity
D1J63_RS05490	COG0673	inositol 2-dehydrogenase activity
D1J63_RS05500	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1J63_RS05505	COG1129	ABC transporter
D1J63_RS05520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J63_RS05530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1J63_RS05535	COG3383	formate dehydrogenase (NAD+) activity
D1J63_RS05540	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1J63_RS05550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1J63_RS05555	COG1846	Transcriptional regulator
D1J63_RS05580	COG0477	Major facilitator Superfamily
D1J63_RS05590	COG0656	L-ascorbic acid biosynthetic process
D1J63_RS05595	COG4221	oxidoreductase activity
D1J63_RS05600	COG2226	methyltransferase
D1J63_RS05605	COG5297	Belongs to the glycosyl hydrolase family 6
D1J63_RS05615	COG5297	Belongs to the glycosyl hydrolase family 6
D1J63_RS05615	COG4733	cellulase activity
D1J63_RS05630	COG3401	FG-GAP repeat protein
D1J63_RS05640	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1J63_RS05670	COG1140	nitrate reductase beta subunit
D1J63_RS05710	COG0531	amino acid
D1J63_RS05765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1J63_RS05775	COG0693	protein deglycase activity
D1J63_RS05790	COG0488	(ABC) transporter
D1J63_RS05795	COG1597	lipid kinase activity
D1J63_RS05860	COG1793	dna ligase
D1J63_RS05860	COG3285	dna ligase
D1J63_RS05875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J63_RS05905	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1J63_RS05915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J63_RS05920	COG2362	D-Aminopeptidase
D1J63_RS05960	COG0596	Alpha beta hydrolase
D1J63_RS05995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS05995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS06000	COG2301	Belongs to the HpcH HpaI aldolase family
D1J63_RS06010	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS06015	COG0688	phosphatidylethanolamine metabolic process
D1J63_RS06025	COG1929	Belongs to the glycerate kinase type-1 family
D1J63_RS06035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1J63_RS06045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1J63_RS06060	COG0640	Transcriptional regulator
D1J63_RS06080	COG0444	Belongs to the ABC transporter superfamily
D1J63_RS06085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J63_RS06090	COG0601	transmembrane transport
D1J63_RS06100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1J63_RS06110	COG0483	inositol monophosphate 1-phosphatase activity
D1J63_RS06125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D1J63_RS06135	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS06140	COG1891	lyase activity
D1J63_RS06150	COG4585	Histidine kinase
D1J63_RS06160	COG2197	response regulator
D1J63_RS06180	COG1953	Uracil, thiamine, allantoin
D1J63_RS06185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J63_RS06190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1J63_RS06205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1J63_RS06230	COG0405	Gamma-glutamyltransferase
D1J63_RS06265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1J63_RS06270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J63_RS06285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1J63_RS06325	COG5297	Belongs to the glycosyl hydrolase family 6
D1J63_RS06325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1J63_RS06330	COG1482	cell wall glycoprotein biosynthetic process
D1J63_RS06335	COG1940	carbohydrate kinase activity
D1J63_RS06340	COG1609	Transcriptional regulator
D1J63_RS06345	COG3250	beta-galactosidase activity
D1J63_RS06355	COG1175	transmembrane transport
D1J63_RS06360	COG3833	ABC-type maltose transport systems, permease component
D1J63_RS06390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1J63_RS06410	COG1132	(ABC) transporter
D1J63_RS06415	COG1132	(ABC) transporter
D1J63_RS06445	COG1509	lysine 2,3-aminomutase activity
D1J63_RS06470	COG0673	inositol 2-dehydrogenase activity
D1J63_RS06475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J63_RS06480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1J63_RS06500	COG3173	Aminoglycoside phosphotransferase
D1J63_RS06520	COG3971	2-oxopent-4-enoate hydratase activity
D1J63_RS06535	COG3209	COG3209 Rhs family protein
D1J63_RS06535	COG4104	PAAR repeat-containing protein
D1J63_RS06545	COG1115	amino acid carrier protein
D1J63_RS06555	COG1032	radical SAM domain protein
D1J63_RS06560	COG0437	4 iron, 4 sulfur cluster binding
D1J63_RS06580	COG3383	formate dehydrogenase (NAD+) activity
D1J63_RS06580	COG0243	molybdopterin cofactor binding
D1J63_RS06585	COG0243	molybdopterin cofactor binding
D1J63_RS06585	COG3383	formate dehydrogenase (NAD+) activity
D1J63_RS06590	COG0709	Synthesizes selenophosphate from selenide and ATP
D1J63_RS06615	COG3246	L-lysine catabolic process to acetate
D1J63_RS06620	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J63_RS06630	COG0277	FAD linked oxidase domain protein
D1J63_RS06630	COG0247	lactate metabolic process
D1J63_RS06640	COG1132	(ABC) transporter
D1J63_RS06645	COG1802	Transcriptional regulator
D1J63_RS06650	COG3938	Belongs to the proline racemase family
D1J63_RS06655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J63_RS06660	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1J63_RS06665	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1J63_RS06665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1J63_RS06670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J63_RS06680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1J63_RS06690	COG1940	carbohydrate kinase activity
D1J63_RS06710	COG2188	Transcriptional regulator
D1J63_RS06715	COG0673	inositol 2-dehydrogenase activity
D1J63_RS06720	COG2197	response regulator
D1J63_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS06745	COG4266	Belongs to the allantoicase family
D1J63_RS06750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1J63_RS06755	COG1414	Transcriptional regulator
D1J63_RS06770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1J63_RS06785	COG0346	lactoylglutathione lyase activity
D1J63_RS06805	COG4264	IucA IucC family
D1J63_RS06830	COG0406	alpha-ribazole phosphatase activity
D1J63_RS06845	COG2233	PERMEase
D1J63_RS06855	COG2233	PERMEase
D1J63_RS06865	COG2351	hydroxyisourate hydrolase activity
D1J63_RS06885	COG3622	Belongs to the hyi family
D1J63_RS06890	COG2084	Dehydrogenase
D1J63_RS06895	COG0753	catalase activity
D1J63_RS06910	COG3960	tartronate-semialdehyde synthase activity
D1J63_RS06920	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS06925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1J63_RS06930	COG2197	response regulator
D1J63_RS06945	COG2319	Wd-40 repeat
D1J63_RS06945	COG4249	Peptidase C14 caspase catalytic subunit p20
D1J63_RS06985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1J63_RS06985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1J63_RS06990	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1J63_RS06995	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS07005	COG0859	PFAM glycosyl transferase family 9
D1J63_RS07020	COG2192	nodulation
D1J63_RS07030	COG0726	polysaccharide deacetylase
D1J63_RS07050	COG2252	PERMEase
D1J63_RS07055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J63_RS07075	COG3835	regulator
D1J63_RS07105	COG3851	Histidine kinase
D1J63_RS07110	COG2197	response regulator
D1J63_RS07120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1J63_RS07125	COG1802	Transcriptional regulator
D1J63_RS07145	COG0028	Belongs to the TPP enzyme family
D1J63_RS07165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1J63_RS07175	COG1162	GTPase activity
D1J63_RS07180	COG4585	Histidine kinase
D1J63_RS07185	COG2197	response regulator
D1J63_RS07190	COG3547	Transposase (IS116 IS110 IS902 family)
D1J63_RS07205	COG1131	(ABC) transporter
D1J63_RS07215	COG0277	FAD linked oxidase domain protein
D1J63_RS07250	COG2197	response regulator
D1J63_RS07255	COG4585	Histidine kinase
D1J63_RS07265	COG2040	homocysteine
D1J63_RS07275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1J63_RS07280	COG0473	3-isopropylmalate dehydrogenase activity
D1J63_RS07280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1J63_RS07290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1J63_RS07295	COG0583	DNA-binding transcription factor activity
D1J63_RS07300	COG2814	Major facilitator Superfamily
D1J63_RS07305	COG1942	4-Oxalocrotonate Tautomerase
D1J63_RS07310	COG0583	DNA-binding transcription factor activity
D1J63_RS07340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1J63_RS07345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1J63_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS07360	COG1063	alcohol dehydrogenase
D1J63_RS07370	COG2814	Major facilitator Superfamily
D1J63_RS07385	COG0714	Associated with various cellular activities
D1J63_RS07400	COG2027	D-alanyl-D-alanine carboxypeptidase
D1J63_RS07465	COG3142	Participates in the control of copper homeostasis
D1J63_RS07475	COG1940	carbohydrate kinase activity
D1J63_RS07475	COG1846	Transcriptional regulator
D1J63_RS07510	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS07530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1J63_RS07540	COG0175	sulfate reduction
D1J63_RS07545	COG0529	Catalyzes the synthesis of activated sulfate
D1J63_RS07570	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D1J63_RS07575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1J63_RS07600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1J63_RS07670	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1J63_RS07675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1J63_RS07690	COG3173	Aminoglycoside phosphotransferase
D1J63_RS07700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1J63_RS07720	COG1309	transcriptional regulator
D1J63_RS07755	COG1174	glycine betaine transport
D1J63_RS07760	COG1174	glycine betaine transport
D1J63_RS07770	COG0745	RESPONSE REGULATOR receiver
D1J63_RS07775	COG2205	protein histidine kinase activity
D1J63_RS07780	COG3433	isochorismatase activity
D1J63_RS07780	COG2226	methyltransferase
D1J63_RS07780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J63_RS07785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1J63_RS07865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1J63_RS07870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1J63_RS07900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J63_RS07900	COG0723	plastoquinol--plastocyanin reductase activity
D1J63_RS07920	COG3220	belongs to the UPF0276 family
D1J63_RS07935	COG3253	May function as heme-dependent peroxidase
D1J63_RS07940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1J63_RS07950	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1J63_RS07990	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J63_RS07995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1J63_RS08010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1J63_RS08015	COG0183	Belongs to the thiolase family
D1J63_RS08020	COG1024	Enoyl-CoA hydratase
D1J63_RS08020	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J63_RS08025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1J63_RS08030	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS08040	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS08045	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS08050	COG1316	TRANSCRIPTIONal
D1J63_RS08070	COG0531	amino acid
D1J63_RS08075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1J63_RS08085	COG3979	chitinase
D1J63_RS08090	COG4214	carbohydrate transport
D1J63_RS08100	COG4213	ABC transporter substrate-binding protein
D1J63_RS08105	COG1940	carbohydrate kinase activity
D1J63_RS08110	COG0395	ABC-type sugar transport system, permease component
D1J63_RS08115	COG1175	transmembrane transport
D1J63_RS08120	COG1653	transport
D1J63_RS08155	COG0395	ABC-type sugar transport system, permease component
D1J63_RS08160	COG4209	transmembrane transport
D1J63_RS08165	COG3458	cephalosporin-C deacetylase activity
D1J63_RS08175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1J63_RS08185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1J63_RS08195	COG0778	Nitroreductase
D1J63_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS08215	COG1309	transcriptional regulator
D1J63_RS08230	COG0583	DNA-binding transcription factor activity
D1J63_RS08250	COG0395	ABC-type sugar transport system, permease component
D1J63_RS08255	COG1175	transmembrane transport
D1J63_RS08265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1J63_RS08270	COG1349	DNA-binding transcription factor activity
D1J63_RS08275	COG0785	Cytochrome C biogenesis protein
D1J63_RS08280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1J63_RS08280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1J63_RS08350	COG1024	Enoyl-CoA hydratase
D1J63_RS08360	COG0531	amino acid
D1J63_RS08365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1J63_RS08370	COG2235	arginine
D1J63_RS08375	COG0475	glutathione-regulated potassium exporter activity
D1J63_RS08380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1J63_RS08410	COG1799	cell septum assembly
D1J63_RS08415	COG0277	FAD linked oxidase domain protein
D1J63_RS08415	COG0247	lactate metabolic process
D1J63_RS08430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1J63_RS08440	COG0310	cobalt ion transport
D1J63_RS08445	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
D1J63_RS08455	COG1122	ATPase activity
D1J63_RS08475	COG0477	Major facilitator Superfamily
D1J63_RS08490	COG2205	protein histidine kinase activity
D1J63_RS08495	COG0745	RESPONSE REGULATOR receiver
D1J63_RS08505	COG2409	Drug exporters of the RND superfamily
D1J63_RS08515	COG2814	Major facilitator Superfamily
D1J63_RS08530	COG1309	transcriptional regulator
D1J63_RS08535	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS08550	COG1309	transcriptional regulator
D1J63_RS08560	COG3693	PFAM glycoside hydrolase, family 10
D1J63_RS08575	COG3654	unkown
D1J63_RS08620	COG3291	Pkd domain containing protein
D1J63_RS08655	COG3654	unkown
D1J63_RS08665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1J63_RS08670	COG0531	amino acid
D1J63_RS08695	COG0500	methyltransferase
D1J63_RS08705	COG1088	dTDP-glucose 4,6-dehydratase activity
D1J63_RS08715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J63_RS08720	COG0156	8-amino-7-oxononanoate synthase activity
D1J63_RS08725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS08730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J63_RS08735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS08740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J63_RS08745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1J63_RS08775	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS08790	COG3629	intracellular signal transduction
D1J63_RS08795	COG0569	domain protein
D1J63_RS08825	COG1136	(ABC) transporter
D1J63_RS08825	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1J63_RS08835	COG0756	dUTP diphosphatase activity
D1J63_RS08860	COG2205	protein histidine kinase activity
D1J63_RS08865	COG0745	RESPONSE REGULATOR receiver
D1J63_RS08880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1J63_RS08920	COG1435	thymidine kinase activity
D1J63_RS08945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1J63_RS08950	COG1802	Transcriptional regulator
D1J63_RS08965	COG0612	Peptidase, M16
D1J63_RS08970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1J63_RS08975	COG0523	cobalamin synthesis protein
D1J63_RS08990	COG0372	Belongs to the citrate synthase family
D1J63_RS09005	COG3290	protein histidine kinase activity
D1J63_RS09010	COG4565	transcriptional regulatory protein
D1J63_RS09015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1J63_RS09025	COG0187	DNA topoisomerase II activity
D1J63_RS09040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1J63_RS09045	COG2186	Transcriptional regulator
D1J63_RS09080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1J63_RS09100	COG0588	phosphoglycerate mutase activity
D1J63_RS09115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1J63_RS09120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1J63_RS09125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1J63_RS09160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1J63_RS09170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1J63_RS09175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1J63_RS09185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1J63_RS09205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1J63_RS09210	COG5297	Belongs to the glycosyl hydrolase family 6
D1J63_RS09210	COG4733	cellulase activity
D1J63_RS09215	COG2197	response regulator
D1J63_RS09220	COG3851	Histidine kinase
D1J63_RS09245	COG2205	protein histidine kinase activity
D1J63_RS09250	COG0745	RESPONSE REGULATOR receiver
D1J63_RS09255	COG1126	abc transporter atp-binding protein
D1J63_RS09260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J63_RS09265	COG0765	amino acid transport
D1J63_RS09270	COG0765	amino acid transport
D1J63_RS09285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1J63_RS09295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1J63_RS09305	COG0628	permease
D1J63_RS09330	COG2207	Transcriptional regulator
D1J63_RS09330	COG1917	Cupin 2, conserved barrel domain protein
D1J63_RS09335	COG1201	RNA secondary structure unwinding
D1J63_RS09340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1J63_RS09360	COG0783	Belongs to the Dps family
D1J63_RS09365	COG1396	sequence-specific DNA binding
D1J63_RS09370	COG1058	Belongs to the CinA family
D1J63_RS09370	COG1546	Belongs to the CinA family
D1J63_RS09380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1J63_RS09390	COG1674	ftsk spoiiie
D1J63_RS09400	COG0784	Response regulator, receiver
D1J63_RS09400	COG2205	protein histidine kinase activity
D1J63_RS09410	COG2770	Histidine kinase
D1J63_RS09410	COG2208	phosphoserine phosphatase activity
D1J63_RS09445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D1J63_RS09450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J63_RS09455	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D1J63_RS09475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1J63_RS09480	COG0612	Peptidase, M16
D1J63_RS09485	COG1185	polyribonucleotide nucleotidyltransferase activity
D1J63_RS09490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1J63_RS09510	COG1674	ftsk spoiiie
D1J63_RS09525	COG1404	Belongs to the peptidase S8 family
D1J63_RS09580	COG3266	domain, Protein
D1J63_RS09595	COG0455	bacterial-type flagellum organization
D1J63_RS09600	COG0747	negative chemotaxis
D1J63_RS09605	COG0601	transmembrane transport
D1J63_RS09620	COG4608	Belongs to the ABC transporter superfamily
D1J63_RS09640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1J63_RS09645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1J63_RS09655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1J63_RS09670	COG0779	Required for maturation of 30S ribosomal subunits
D1J63_RS09695	COG0442	prolyl-tRNA aminoacylation
D1J63_RS09710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1J63_RS09715	COG0750	zinc metalloprotease
D1J63_RS09720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D1J63_RS09750	COG0395	ABC-type sugar transport system, permease component
D1J63_RS09755	COG4209	transmembrane transport
D1J63_RS09775	COG2197	response regulator
D1J63_RS09790	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS09795	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS09800	COG2508	Transcriptional regulator
D1J63_RS09840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J63_RS09845	COG1177	transmembrane transport
D1J63_RS09855	COG3842	ATPase activity
D1J63_RS09885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J63_RS09910	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS09920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1J63_RS09955	COG3842	ATPase activity
D1J63_RS09960	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D1J63_RS09970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1J63_RS09975	COG0575	Belongs to the CDS family
D1J63_RS09980	COG0233	cytoplasmic translational termination
D1J63_RS09985	COG0528	UMP kinase activity
D1J63_RS09990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1J63_RS09995	COG0052	Belongs to the universal ribosomal protein uS2 family
D1J63_RS10000	COG4942	peptidase
D1J63_RS10010	COG1191	sigma factor activity
D1J63_RS10025	COG0792	nuclease activity
D1J63_RS10045	COG0681	Belongs to the peptidase S26 family
D1J63_RS10060	COG0335	large ribosomal subunit rRNA binding
D1J63_RS10065	COG0336	Belongs to the RNA methyltransferase TrmD family
D1J63_RS10070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1J63_RS10075	COG1837	Belongs to the UPF0109 family
D1J63_RS10080	COG0228	four-way junction DNA binding
D1J63_RS10105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1J63_RS10140	COG0477	Major facilitator Superfamily
D1J63_RS10155	COG1254	Belongs to the acylphosphatase family
D1J63_RS10165	COG1733	regulation of RNA biosynthetic process
D1J63_RS10170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1J63_RS10175	COG0571	ribonuclease III activity
D1J63_RS10180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1J63_RS10195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1J63_RS10200	COG0742	ribosomal rna small subunit methyltransferase
D1J63_RS10215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1J63_RS10230	COG0351	phosphomethylpyrimidine kinase
D1J63_RS10245	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1J63_RS10250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1J63_RS10260	COG1920	GTP binding
D1J63_RS10270	COG0776	regulation of translation
D1J63_RS10280	COG0066	3-isopropylmalate dehydratase activity
D1J63_RS10285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1J63_RS10290	COG1414	Transcriptional regulator
D1J63_RS10340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1J63_RS10345	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1J63_RS10355	COG5002	protein histidine kinase activity
D1J63_RS10360	COG2018	Roadblock/LC7 domain
D1J63_RS10380	COG2018	Roadblock/LC7 domain
D1J63_RS10400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J63_RS10405	COG5492	domain, Protein
D1J63_RS10410	COG2353	YceI-like domain
D1J63_RS10415	COG1335	isochorismatase
D1J63_RS10435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1J63_RS10445	COG2957	Belongs to the agmatine deiminase family
D1J63_RS10450	COG0804	urea catabolic process
D1J63_RS10455	COG0832	Belongs to the urease beta subunit family
D1J63_RS10455	COG0831	urea catabolic process
D1J63_RS10465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1J63_RS10470	COG0473	3-isopropylmalate dehydrogenase activity
D1J63_RS10480	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS10485	COG0506	proline dehydrogenase activity
D1J63_RS10500	COG0477	Major facilitator Superfamily
D1J63_RS10505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1J63_RS10510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1J63_RS10515	COG0440	acetolactate synthase activity
D1J63_RS10525	COG5001	Diguanylate cyclase
D1J63_RS10535	COG0667	Aldo Keto reductase
D1J63_RS10540	COG2133	pyrroloquinoline quinone binding
D1J63_RS10550	COG2197	response regulator
D1J63_RS10565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J63_RS10570	COG2409	Drug exporters of the RND superfamily
D1J63_RS10575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1J63_RS10585	COG0154	amidase activity
D1J63_RS10590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1J63_RS10615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1J63_RS10625	COG4221	oxidoreductase activity
D1J63_RS10630	COG1611	Belongs to the LOG family
D1J63_RS10645	COG0482	sulfurtransferase activity
D1J63_RS10680	COG0789	Transcriptional regulator
D1J63_RS10690	COG2860	membrane
D1J63_RS10695	COG4608	Belongs to the ABC transporter superfamily
D1J63_RS10700	COG0444	Belongs to the ABC transporter superfamily
D1J63_RS10715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J63_RS10735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1J63_RS10740	COG0509	glycine decarboxylation via glycine cleavage system
D1J63_RS10745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1J63_RS10750	COG1760	l-serine dehydratase
D1J63_RS10755	COG0492	ferredoxin-NADP+ reductase activity
D1J63_RS10760	COG0277	FAD linked oxidase domain protein
D1J63_RS10765	COG1045	serine acetyltransferase
D1J63_RS10785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1J63_RS10790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1J63_RS10805	COG0431	NADPH-dependent FMN reductase
D1J63_RS10820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1J63_RS10835	COG1063	alcohol dehydrogenase
D1J63_RS10855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1J63_RS10860	COG2223	nitrite transmembrane transporter activity
D1J63_RS10865	COG0243	molybdopterin cofactor binding
D1J63_RS10875	COG2146	nitrite reductase [NAD(P)H] activity
D1J63_RS10875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1J63_RS10890	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1J63_RS10900	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1J63_RS10915	COG1959	2 iron, 2 sulfur cluster binding
D1J63_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS10980	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS10980	COG0300	oxidoreductase activity
D1J63_RS10980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J63_RS10980	COG3321	synthase
D1J63_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS10985	COG2207	Transcriptional regulator
D1J63_RS10990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1J63_RS11005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1J63_RS11020	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1J63_RS11040	COG0583	DNA-binding transcription factor activity
D1J63_RS11055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1J63_RS11060	COG1309	transcriptional regulator
D1J63_RS11080	COG3467	pyridoxamine 5'-phosphate
D1J63_RS11090	COG3321	synthase
D1J63_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS11090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1J63_RS11090	COG0300	oxidoreductase activity
D1J63_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS11130	COG0789	Transcriptional regulator
D1J63_RS11155	COG1376	ErfK ybiS ycfS ynhG family protein
D1J63_RS11170	COG2197	response regulator
D1J63_RS11175	COG4585	Histidine kinase
D1J63_RS11185	COG1131	(ABC) transporter
D1J63_RS11190	COG1132	(ABC) transporter
D1J63_RS11195	COG1132	(ABC) transporter
D1J63_RS11200	COG1132	(ABC) transporter
D1J63_RS11205	COG1132	(ABC) transporter
D1J63_RS11225	COG0058	SHG alpha-glucan phosphorylase activity
D1J63_RS11230	COG0366	Alpha amylase catalytic
D1J63_RS11235	COG0366	Alpha amylase catalytic
D1J63_RS11240	COG3281	Trehalose synthase
D1J63_RS11255	COG3118	belongs to the thioredoxin family
D1J63_RS11265	COG1301	dicarboxylic acid transport
D1J63_RS11270	COG3290	protein histidine kinase activity
D1J63_RS11275	COG4565	transcriptional regulatory protein
D1J63_RS11285	COG1653	transport
D1J63_RS11295	COG0395	ABC-type sugar transport system, permease component
D1J63_RS11310	COG0667	Aldo Keto reductase
D1J63_RS11320	COG0205	6-phosphofructokinase activity
D1J63_RS11325	COG0857	belongs to the CobB CobQ family
D1J63_RS11325	COG0280	phosphate acetyltransferase
D1J63_RS11330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1J63_RS11370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS11370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS11415	COG2205	protein histidine kinase activity
D1J63_RS11420	COG0745	RESPONSE REGULATOR receiver
D1J63_RS11440	COG0183	Belongs to the thiolase family
D1J63_RS11460	COG1131	(ABC) transporter
D1J63_RS11495	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1J63_RS11510	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J63_RS11545	COG2197	response regulator
D1J63_RS11560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1J63_RS11565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1J63_RS11570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1J63_RS11575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1J63_RS11580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1J63_RS11585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1J63_RS11590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1J63_RS11605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1J63_RS11610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1J63_RS11615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1J63_RS11625	COG2890	protein-(glutamine-N5) methyltransferase activity
D1J63_RS11630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1J63_RS11635	COG0254	rRNA binding
D1J63_RS11640	COG1316	TRANSCRIPTIONal
D1J63_RS11655	COG0083	homoserine kinase activity
D1J63_RS11660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1J63_RS11665	COG0460	homoserine dehydrogenase
D1J63_RS11670	COG0019	diaminopimelate decarboxylase activity
D1J63_RS11675	COG0018	arginyl-trna synthetase
D1J63_RS11675	COG0018	arginyl-trna synthetase
D1J63_RS11680	COG0745	RESPONSE REGULATOR receiver
D1J63_RS11710	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D1J63_RS11750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1J63_RS11760	COG1733	regulation of RNA biosynthetic process
D1J63_RS11790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J63_RS11795	COG2329	Antibiotic biosynthesis monooxygenase
D1J63_RS11800	COG0662	Cupin 2, conserved barrel domain protein
D1J63_RS11805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J63_RS11810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J63_RS11815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS11820	COG2867	negative regulation of translational initiation
D1J63_RS11835	COG3467	pyridoxamine 5'-phosphate
D1J63_RS11850	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D1J63_RS11855	COG1793	dna ligase
D1J63_RS11855	COG3285	dna ligase
D1J63_RS11875	COG2205	protein histidine kinase activity
D1J63_RS11915	COG0791	NLP P60 protein
D1J63_RS11915	COG3883	PFAM NLP P60 protein
D1J63_RS11960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1J63_RS11970	COG0745	RESPONSE REGULATOR receiver
D1J63_RS11975	COG2205	protein histidine kinase activity
D1J63_RS11980	COG0567	Dehydrogenase, E1 component
D1J63_RS11980	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J63_RS12045	COG0542	response to heat
D1J63_RS12055	COG0604	alcohol dehydrogenase
D1J63_RS12060	COG0281	malic enzyme
D1J63_RS12080	COG1126	abc transporter atp-binding protein
D1J63_RS12085	COG4106	trans-aconitate 2-methyltransferase activity
D1J63_RS12120	COG0142	geranyltranstransferase activity
D1J63_RS12125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1J63_RS12165	COG1597	lipid kinase activity
D1J63_RS12190	COG0363	glucosamine-6-phosphate deaminase activity
D1J63_RS12195	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J63_RS12200	COG0395	ABC-type sugar transport system, permease component
D1J63_RS12205	COG1175	transmembrane transport
D1J63_RS12210	COG2182	Extracellular solute-binding protein
D1J63_RS12215	COG2188	Transcriptional regulator
D1J63_RS12255	COG2124	cytochrome p450
D1J63_RS12265	COG0242	peptide deformylase activity
D1J63_RS12285	COG5662	AntiSigma factor
D1J63_RS12290	COG1595	DNA-templated transcription, initiation
D1J63_RS12300	COG2135	peptidase activity
D1J63_RS12310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1J63_RS12320	COG2076	Multidrug Resistance protein
D1J63_RS12330	COG0483	inositol monophosphate 1-phosphatase activity
D1J63_RS12340	COG0753	catalase activity
D1J63_RS12365	COG1615	UPF0182 protein
D1J63_RS12375	COG3480	Lon protease (S16) C-terminal proteolytic domain
D1J63_RS12430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1J63_RS12460	COG2816	NAD+ diphosphatase activity
D1J63_RS12470	COG0210	DNA helicase
D1J63_RS12500	COG0596	Alpha beta hydrolase
D1J63_RS12535	COG0596	Alpha beta hydrolase
D1J63_RS12535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1J63_RS12570	COG0513	Belongs to the DEAD box helicase family
D1J63_RS12580	COG1432	Conserved Protein
D1J63_RS12590	COG2095	MarC family integral membrane protein
D1J63_RS12595	COG0613	PHP domain protein
D1J63_RS12605	COG2814	Major facilitator Superfamily
D1J63_RS12615	COG0598	Magnesium transport protein CorA
D1J63_RS12650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1J63_RS12655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J63_RS12665	COG1595	DNA-templated transcription, initiation
D1J63_RS12680	COG1024	Enoyl-CoA hydratase
D1J63_RS12685	COG0519	Catalyzes the synthesis of GMP from XMP
D1J63_RS12695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1J63_RS12705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J63_RS12750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J63_RS12780	COG0444	Belongs to the ABC transporter superfamily
D1J63_RS12785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J63_RS12790	COG0601	transmembrane transport
D1J63_RS12800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J63_RS12805	COG0747	negative chemotaxis
D1J63_RS12815	COG0444	Belongs to the ABC transporter superfamily
D1J63_RS12820	COG4608	Belongs to the ABC transporter superfamily
D1J63_RS12825	COG4608	Belongs to the ABC transporter superfamily
D1J63_RS12830	COG0444	Belongs to the ABC transporter superfamily
D1J63_RS12835	COG0601	transmembrane transport
D1J63_RS12840	COG0747	negative chemotaxis
D1J63_RS12845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1J63_RS12850	COG1217	gtp-binding protein TYPA
D1J63_RS12880	COG1053	succinate dehydrogenase
D1J63_RS12885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1J63_RS12935	COG0300	oxidoreductase activity
D1J63_RS12940	COG0583	DNA-binding transcription factor activity
D1J63_RS12955	COG2318	DinB family
D1J63_RS12975	COG2264	protein methyltransferase activity
D1J63_RS12995	COG0012	GTP binding
D1J63_RS13010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1J63_RS13020	COG1570	exodeoxyribonuclease VII activity
D1J63_RS13025	COG1722	exodeoxyribonuclease VII activity
D1J63_RS13035	COG0778	Nitroreductase
D1J63_RS13060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D1J63_RS13060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D1J63_RS13070	COG0114	fumarate hydratase activity
D1J63_RS13085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J63_RS13105	COG1136	(ABC) transporter
D1J63_RS13120	COG0450	alkyl hydroperoxide reductase
D1J63_RS13125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J63_RS13135	COG0741	lytic transglycosylase activity
D1J63_RS13140	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D1J63_RS13150	COG2226	methyltransferase
D1J63_RS13220	COG2894	cell division
D1J63_RS13270	COG2610	gluconate transmembrane transporter activity
D1J63_RS13275	COG0251	oxidation-reduction process
D1J63_RS13280	COG1414	Transcriptional regulator
D1J63_RS13295	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D1J63_RS13300	COG0436	Aminotransferase
D1J63_RS13310	COG2267	carboxylic ester hydrolase activity
D1J63_RS13315	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D1J63_RS13335	COG1331	Highly conserved protein containing a thioredoxin domain
D1J63_RS13340	COG0590	tRNA wobble adenosine to inosine editing
D1J63_RS13350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J63_RS13365	COG2255	four-way junction helicase activity
D1J63_RS13375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J63_RS13385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1J63_RS13400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1J63_RS13430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1J63_RS13460	COG0667	Aldo Keto reductase
D1J63_RS13475	COG1140	nitrate reductase beta subunit
D1J63_RS13485	COG1090	epimerase
D1J63_RS13490	COG1064	alcohol dehydrogenase
D1J63_RS13505	COG1309	transcriptional regulator
D1J63_RS13525	COG1136	(ABC) transporter
D1J63_RS13545	COG2986	histidine ammonia-lyase
D1J63_RS13555	COG1024	Enoyl-CoA hydratase
D1J63_RS13565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J63_RS13575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J63_RS13590	COG0424	maF-like protein
D1J63_RS13600	COG4770	biotin carboxylase activity
D1J63_RS13630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1J63_RS13645	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS13650	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS13655	COG0515	serine threonine protein kinase
D1J63_RS13680	COG1595	DNA-templated transcription, initiation
D1J63_RS13685	COG0745	RESPONSE REGULATOR receiver
D1J63_RS13690	COG2205	protein histidine kinase activity
D1J63_RS13715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J63_RS13720	COG1959	2 iron, 2 sulfur cluster binding
D1J63_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS13735	COG0583	DNA-binding transcription factor activity
D1J63_RS13740	COG2814	Major facilitator Superfamily
D1J63_RS13785	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1J63_RS13790	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1J63_RS13795	COG3845	ABC transporter
D1J63_RS13800	COG1744	ABC transporter substrate-binding protein PnrA-like
D1J63_RS13805	COG1744	ABC transporter substrate-binding protein PnrA-like
D1J63_RS13810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J63_RS13810	COG1473	amidohydrolase
D1J63_RS13820	COG2089	acid synthase
D1J63_RS13835	COG1216	Glycosyl transferase, family 2
D1J63_RS13850	COG0463	Glycosyl transferase, family 2
D1J63_RS13885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS13885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS13900	COG1595	DNA-templated transcription, initiation
D1J63_RS13910	COG1595	DNA-templated transcription, initiation
D1J63_RS13940	COG2009	succinate dehydrogenase
D1J63_RS13950	COG1053	succinate dehydrogenase
D1J63_RS13980	COG1309	transcriptional regulator
D1J63_RS13985	COG1408	metallophosphoesterase
D1J63_RS13995	COG1686	Belongs to the peptidase S11 family
D1J63_RS14015	COG0671	phosphoesterase, PA-phosphatase related
D1J63_RS14035	COG0180	Tryptophanyl-tRNA synthetase
D1J63_RS14045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1J63_RS14050	COG0754	glutathionylspermidine amidase activity
D1J63_RS14060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J63_RS14065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J63_RS14070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J63_RS14075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1J63_RS14085	COG4176	ABC-type proline glycine betaine transport system permease component
D1J63_RS14090	COG0517	IMP dehydrogenase activity
D1J63_RS14090	COG4175	Glycine betaine
D1J63_RS14100	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS14105	COG0039	L-malate dehydrogenase activity
D1J63_RS14120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1J63_RS14155	COG2815	serine threonine protein kinase
D1J63_RS14155	COG0515	serine threonine protein kinase
D1J63_RS14165	COG0138	bifunctional purine biosynthesis protein purh
D1J63_RS14200	COG0045	succinate-CoA ligase (ADP-forming) activity
D1J63_RS14210	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D1J63_RS14220	COG0714	Associated with various cellular activities
D1J63_RS14235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS14235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1J63_RS14245	COG0739	heme binding
D1J63_RS14270	COG0791	NLP P60 protein
D1J63_RS14275	COG2197	response regulator
D1J63_RS14310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1J63_RS14310	COG0519	Catalyzes the synthesis of GMP from XMP
D1J63_RS14335	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS14340	COG0515	serine threonine protein kinase
D1J63_RS14350	COG0515	serine threonine protein kinase
D1J63_RS14355	COG0515	serine threonine protein kinase
D1J63_RS14355	COG2815	serine threonine protein kinase
D1J63_RS14375	COG0516	GMP reductase activity
D1J63_RS14385	COG1595	DNA-templated transcription, initiation
D1J63_RS14400	COG0583	DNA-binding transcription factor activity
D1J63_RS14410	COG4221	oxidoreductase activity
D1J63_RS14440	COG0459	protein refolding
D1J63_RS14445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1J63_RS14450	COG0726	polysaccharide deacetylase
D1J63_RS14455	COG0726	polysaccharide deacetylase
D1J63_RS14465	COG4941	Belongs to the sigma-70 factor family
D1J63_RS14490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1J63_RS14490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1J63_RS14510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1J63_RS14520	COG1214	PFAM Peptidase M22, glycoprotease
D1J63_RS14520	COG0456	acetyltransferase
D1J63_RS14540	COG0802	atpase or kinase
D1J63_RS14550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1J63_RS14555	COG0736	holo-[acyl-carrier-protein] synthase activity
D1J63_RS14575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1J63_RS14585	COG1072	(Pantothenic acid kinase))
D1J63_RS14600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1J63_RS14605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1J63_RS14610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1J63_RS14625	COG0101	tRNA pseudouridine synthase activity
D1J63_RS14630	COG0203	ribosomal protein L17
D1J63_RS14640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1J63_RS14645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1J63_RS14650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1J63_RS14655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1J63_RS14665	COG0563	adenylate kinase activity
D1J63_RS14670	COG0201	protein transport
D1J63_RS14675	COG0200	Binds to the 23S rRNA
D1J63_RS14680	COG1841	ribosomal large subunit assembly
D1J63_RS14685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1J63_RS14690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1J63_RS14695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1J63_RS14700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1J63_RS14710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1J63_RS14715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1J63_RS14720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1J63_RS14725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1J63_RS14730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1J63_RS14735	COG0255	Belongs to the universal ribosomal protein uL29 family
D1J63_RS14740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1J63_RS14745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1J63_RS14750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1J63_RS14755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1J63_RS14760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1J63_RS14765	COG0089	rRNA binding
D1J63_RS14770	COG0088	Forms part of the polypeptide exit tunnel
D1J63_RS14775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1J63_RS14780	COG0051	transcription antitermination factor activity, RNA binding
D1J63_RS14820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1J63_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS14880	COG0583	DNA-binding transcription factor activity
D1J63_RS14910	COG2197	response regulator
D1J63_RS14920	COG1136	(ABC) transporter
D1J63_RS14945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1J63_RS14950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1J63_RS14955	COG0049	tRNA binding
D1J63_RS14960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1J63_RS15080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1J63_RS15085	COG0085	RNA polymerase activity
D1J63_RS15095	COG0222	ribosome binding
D1J63_RS15100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1J63_RS15115	COG0081	regulation of translation
D1J63_RS15120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1J63_RS15125	COG0250	Participates in transcription elongation, termination and antitermination
D1J63_RS15130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1J63_RS15140	COG0436	Aminotransferase
D1J63_RS15145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J63_RS15160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1J63_RS15170	COG0477	Major facilitator Superfamily
D1J63_RS15195	COG2030	dehydratase
D1J63_RS15200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1J63_RS15215	COG0402	S-adenosylhomocysteine deaminase activity
D1J63_RS15220	COG0702	epimerase
D1J63_RS15235	COG1666	GTP binding
D1J63_RS15240	COG2261	transglycosylase associated protein
D1J63_RS15250	COG3304	Inner membrane component domain
D1J63_RS15255	COG0501	Belongs to the peptidase M48B family
D1J63_RS15260	COG1007	ATP synthesis coupled electron transport
D1J63_RS15270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1J63_RS15275	COG0713	ATP synthesis coupled electron transport
D1J63_RS15285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1J63_RS15295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1J63_RS15325	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1J63_RS15330	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1J63_RS15335	COG0702	epimerase
D1J63_RS15380	COG0739	heme binding
D1J63_RS15380	COG0741	lytic transglycosylase activity
D1J63_RS15380	COG1196	nuclear chromosome segregation
D1J63_RS15455	COG1131	(ABC) transporter
D1J63_RS15465	COG0142	geranyltranstransferase activity
D1J63_RS15475	COG0561	phosphatase activity
D1J63_RS15490	COG0514	ATP-dependent DNA helicase (RecQ)
D1J63_RS15500	COG1007	ATP synthesis coupled electron transport
D1J63_RS15510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1J63_RS15515	COG0713	ATP synthesis coupled electron transport
D1J63_RS15520	COG0839	Belongs to the complex I subunit 6 family
D1J63_RS15525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1J63_RS15535	COG1034	ATP synthesis coupled electron transport
D1J63_RS15540	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1J63_RS15550	COG0649	NAD binding
D1J63_RS15555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15575	COG0242	peptide deformylase activity
D1J63_RS15595	COG2226	methyltransferase
D1J63_RS15625	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1J63_RS15645	COG0515	serine threonine protein kinase
D1J63_RS15645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J63_RS15650	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1J63_RS15655	COG1278	Cold shock
D1J63_RS15660	COG2226	methyltransferase
D1J63_RS15670	COG0183	Belongs to the thiolase family
D1J63_RS15685	COG1309	transcriptional regulator
D1J63_RS15690	COG1301	dicarboxylic acid transport
D1J63_RS15705	COG1573	uracil-dna glycosylase
D1J63_RS15710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1J63_RS15720	COG0163	prenyltransferase activity
D1J63_RS15725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1J63_RS15730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1J63_RS15785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1J63_RS15790	COG1333	cytochrome c biogenesis protein
D1J63_RS15795	COG0785	Cytochrome C biogenesis protein
D1J63_RS15800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1J63_RS15810	COG0406	alpha-ribazole phosphatase activity
D1J63_RS15815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1J63_RS15840	COG0492	ferredoxin-NADP+ reductase activity
D1J63_RS15845	COG0640	Transcriptional regulator
D1J63_RS15850	COG0798	PFAM Bile acid sodium symporter
D1J63_RS15860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1J63_RS15870	COG1007	ATP synthesis coupled electron transport
D1J63_RS15885	COG0713	ATP synthesis coupled electron transport
D1J63_RS15895	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1J63_RS15905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1J63_RS15950	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J63_RS15950	COG2208	phosphoserine phosphatase activity
D1J63_RS15950	COG2172	sigma factor antagonist activity
D1J63_RS15975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J63_RS15980	COG1742	UPF0060 membrane protein
D1J63_RS15995	COG1690	Belongs to the RtcB family
D1J63_RS16015	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1J63_RS16020	COG0018	arginyl-trna synthetase
D1J63_RS16025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J63_RS16045	COG0113	porphobilinogen synthase activity
D1J63_RS16065	COG3321	synthase
D1J63_RS16065	COG0604	alcohol dehydrogenase
D1J63_RS16080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1J63_RS16080	COG1648	precorrin-2 dehydrogenase activity
D1J63_RS16085	COG0181	hydroxymethylbilane synthase activity
D1J63_RS16090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1J63_RS16095	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D1J63_RS16145	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1J63_RS16155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1J63_RS16180	COG0180	Tryptophanyl-tRNA synthetase
D1J63_RS16195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1J63_RS16205	COG0842	Transport permease protein
D1J63_RS16205	COG1129	ABC transporter
D1J63_RS16230	COG0515	serine threonine protein kinase
D1J63_RS16230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J63_RS16235	COG0129	dihydroxy-acid dehydratase activity
D1J63_RS16245	COG1082	Xylose isomerase domain protein TIM barrel
D1J63_RS16250	COG0248	Ppx GppA phosphatase
D1J63_RS16280	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D1J63_RS16295	COG1194	a g-specific adenine glycosylase
D1J63_RS16300	COG1595	DNA-templated transcription, initiation
D1J63_RS16310	COG0745	RESPONSE REGULATOR receiver
D1J63_RS16315	COG2205	protein histidine kinase activity
D1J63_RS16325	COG0346	lactoylglutathione lyase activity
D1J63_RS16375	COG0739	heme binding
D1J63_RS16420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1J63_RS16445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1J63_RS16455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1J63_RS16460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1J63_RS16485	COG1660	Displays ATPase and GTPase activities
D1J63_RS16505	COG0649	NAD binding
D1J63_RS16550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1J63_RS16570	COG0302	gtp cyclohydrolase
D1J63_RS16585	COG0037	tRNA processing
D1J63_RS16595	COG2027	D-alanyl-D-alanine carboxypeptidase
D1J63_RS16600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1J63_RS16610	COG0586	Pfam SNARE associated Golgi protein
D1J63_RS16615	COG0789	Transcriptional regulator
D1J63_RS16630	COG0076	glutamate decarboxylase activity
D1J63_RS16650	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS16680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1J63_RS16690	COG0254	rRNA binding
D1J63_RS16695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1J63_RS16700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1J63_RS16705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1J63_RS16725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1J63_RS16725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1J63_RS16740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1J63_RS16755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1J63_RS16760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1J63_RS16765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1J63_RS16765	COG1754	DNA topoisomerase type I activity
D1J63_RS16785	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D1J63_RS16790	COG2172	sigma factor antagonist activity
D1J63_RS16795	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J63_RS16800	COG1205	dead DEAH box helicase
D1J63_RS16800	COG1111	helicase
D1J63_RS16860	COG0659	secondary active sulfate transmembrane transporter activity
D1J63_RS16865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1J63_RS16870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1J63_RS16880	COG0596	Alpha beta hydrolase
D1J63_RS16895	COG0494	nUDIX hydrolase
D1J63_RS16915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J63_RS16925	COG0596	Alpha beta hydrolase
D1J63_RS16945	COG0003	Pfam Anion-transporting ATPase
D1J63_RS16960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J63_RS16980	COG1408	metallophosphoesterase
D1J63_RS17005	COG0659	secondary active sulfate transmembrane transporter activity
D1J63_RS17010	COG0640	Transcriptional regulator
D1J63_RS17015	COG2824	Alkylphosphonate utilization operon protein PhnA
D1J63_RS17020	COG1309	transcriptional regulator
D1J63_RS17040	COG2205	protein histidine kinase activity
D1J63_RS17045	COG0745	RESPONSE REGULATOR receiver
D1J63_RS17055	COG1234	tRNA 3'-trailer cleavage
D1J63_RS17065	COG0475	glutathione-regulated potassium exporter activity
D1J63_RS17110	COG1595	DNA-templated transcription, initiation
D1J63_RS17145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1J63_RS17150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1J63_RS17165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1J63_RS17170	COG1802	Transcriptional regulator
D1J63_RS17185	COG1595	DNA-templated transcription, initiation
D1J63_RS17200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1J63_RS17220	COG1131	(ABC) transporter
D1J63_RS17225	COG3559	Exporter of polyketide antibiotics
D1J63_RS17250	COG2197	response regulator
D1J63_RS17260	COG2197	response regulator
D1J63_RS17265	COG4585	Histidine kinase
D1J63_RS17285	COG3844	kynureninase activity
D1J63_RS17300	COG0477	Major facilitator Superfamily
D1J63_RS17305	COG0191	fructose-bisphosphate aldolase activity
D1J63_RS17310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1J63_RS17325	COG2197	response regulator
D1J63_RS17330	COG4585	Histidine kinase
D1J63_RS17335	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1J63_RS17360	COG0542	response to heat
D1J63_RS17390	COG2197	response regulator
D1J63_RS17400	COG1136	(ABC) transporter
D1J63_RS17410	COG4213	ABC transporter substrate-binding protein
D1J63_RS17415	COG0789	Transcriptional regulator
D1J63_RS17420	COG0484	heat shock protein binding
D1J63_RS17425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1J63_RS17430	COG0443	Heat shock 70 kDa protein
D1J63_RS17435	COG0247	lactate metabolic process
D1J63_RS17435	COG2181	nitrate reductase activity
D1J63_RS17460	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1J63_RS17465	COG0717	Belongs to the dCTP deaminase family
D1J63_RS17500	COG1309	transcriptional regulator
D1J63_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS17525	COG1252	NADH dehydrogenase
D1J63_RS17530	COG1595	DNA-templated transcription, initiation
D1J63_RS17535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D1J63_RS17545	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D1J63_RS17615	COG1278	Cold shock
D1J63_RS17620	COG0513	Belongs to the DEAD box helicase family
D1J63_RS17655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1J63_RS17660	COG5002	protein histidine kinase activity
D1J63_RS17665	COG0745	RESPONSE REGULATOR receiver
D1J63_RS17680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1J63_RS17700	COG4585	Histidine kinase
D1J63_RS17710	COG0577	efflux transmembrane transporter activity
D1J63_RS17710	COG1136	(ABC) transporter
D1J63_RS17725	COG0577	efflux transmembrane transporter activity
D1J63_RS17725	COG1136	(ABC) transporter
D1J63_RS17730	COG2197	response regulator
D1J63_RS17735	COG4585	Histidine kinase
D1J63_RS17790	COG0583	DNA-binding transcription factor activity
D1J63_RS17815	COG1957	nucleoside hydrolase
D1J63_RS17820	COG0366	Alpha amylase catalytic
D1J63_RS17885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1J63_RS17895	COG0326	Molecular chaperone. Has ATPase activity
D1J63_RS17930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1J63_RS17945	COG1741	Belongs to the pirin family
D1J63_RS17955	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS17960	COG1362	aminopeptidase activity
D1J63_RS17995	COG2186	Transcriptional regulator
D1J63_RS18020	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J63_RS18025	COG0022	dehydrogenase e1 component
D1J63_RS18045	COG0515	serine threonine protein kinase
D1J63_RS18050	COG0515	serine threonine protein kinase
D1J63_RS18065	COG0604	alcohol dehydrogenase
D1J63_RS18065	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS18065	COG3321	synthase
D1J63_RS18075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1J63_RS18105	COG1522	sequence-specific DNA binding
D1J63_RS18110	COG1309	transcriptional regulator
D1J63_RS18115	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1J63_RS18165	COG1716	ATPase activity
D1J63_RS18170	COG1716	ATPase activity
D1J63_RS18185	COG0768	penicillin binding
D1J63_RS18195	COG0515	serine threonine protein kinase
D1J63_RS18205	COG3764	Sortase (surface protein transpeptidase)
D1J63_RS18210	COG3764	Sortase (surface protein transpeptidase)
D1J63_RS18235	COG0705	Rhomboid family
D1J63_RS18250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1J63_RS18265	COG0515	serine threonine protein kinase
D1J63_RS18310	COG4249	Peptidase C14 caspase catalytic subunit p20
D1J63_RS18310	COG2319	Wd-40 repeat
D1J63_RS18330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1J63_RS18335	COG0187	DNA topoisomerase II activity
D1J63_RS18345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1J63_RS18350	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1J63_RS18355	COG0592	DNA-directed DNA polymerase activity
D1J63_RS18365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1J63_RS18370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1J63_RS18375	COG0594	ribonuclease P activity
D1J63_RS18380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1J63_RS18385	COG0706	membrane insertase activity
D1J63_RS18395	COG0357	Ribosomal RNA small subunit methyltransferase G
D1J63_RS18400	COG1192	Involved in chromosome partitioning
D1J63_RS18415	COG3118	belongs to the thioredoxin family
D1J63_RS18420	COG0492	ferredoxin-NADP+ reductase activity
D1J63_RS18430	COG1595	DNA-templated transcription, initiation
D1J63_RS18450	COG0617	tRNA 3'-terminal CCA addition
D1J63_RS18480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J63_RS18505	COG0360	Binds together with S18 to 16S ribosomal RNA
D1J63_RS18510	COG0629	single-stranded DNA binding
D1J63_RS18515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1J63_RS18520	COG0359	binds to the 23S rRNA
D1J63_RS18530	COG0305	Participates in initiation and elongation during chromosome replication
D1J63_RS18550	COG2814	Major facilitator Superfamily
D1J63_RS18575	COG0626	cystathionine gamma-synthase activity
D1J63_RS18580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1J63_RS18585	COG1950	PFAM Membrane protein of
D1J63_RS18590	COG0662	Cupin 2, conserved barrel domain protein
D1J63_RS18615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1J63_RS18640	COG1609	Transcriptional regulator
D1J63_RS18645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1J63_RS18655	COG1271	oxidase subunit
D1J63_RS18660	COG1294	oxidase, subunit
D1J63_RS18665	COG4988	ABC transporter
D1J63_RS18675	COG0739	heme binding
D1J63_RS18680	COG0561	phosphatase activity
D1J63_RS18695	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D1J63_RS18705	COG1131	(ABC) transporter
D1J63_RS18725	COG0561	phosphatase activity
D1J63_RS18730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1J63_RS18735	COG0077	Prephenate dehydratase
D1J63_RS18740	COG2837	iron assimilation
D1J63_RS18755	COG1999	signal sequence binding
D1J63_RS18780	COG0006	proline dipeptidase activity
D1J63_RS18800	COG0653	protein targeting
D1J63_RS18815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J63_RS18820	COG0604	alcohol dehydrogenase
D1J63_RS18820	COG3321	synthase
D1J63_RS18825	COG1309	transcriptional regulator
D1J63_RS18845	COG0789	Transcriptional regulator
D1J63_RS18865	COG1595	DNA-templated transcription, initiation
D1J63_RS18870	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS18875	COG2814	Major facilitator Superfamily
D1J63_RS18880	COG1309	transcriptional regulator
D1J63_RS18885	COG0784	Response regulator, receiver
D1J63_RS18910	COG0768	penicillin binding
D1J63_RS18915	COG1733	regulation of RNA biosynthetic process
D1J63_RS18930	COG0745	RESPONSE REGULATOR receiver
D1J63_RS18935	COG2205	protein histidine kinase activity
D1J63_RS18945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1J63_RS18955	COG3467	pyridoxamine 5'-phosphate
D1J63_RS18985	COG0477	Major facilitator Superfamily
D1J63_RS19000	COG1191	sigma factor activity
D1J63_RS19005	COG1191	sigma factor activity
D1J63_RS19040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1J63_RS19120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1J63_RS19170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D1J63_RS19220	COG0151	Belongs to the GarS family
D1J63_RS19235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1J63_RS19245	COG2197	response regulator
D1J63_RS19280	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1J63_RS19285	COG0047	phosphoribosylformylglycinamidine synthase activity
D1J63_RS19290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1J63_RS19325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1J63_RS19360	COG1643	Atp-dependent helicase
D1J63_RS19395	COG0513	Belongs to the DEAD box helicase family
D1J63_RS19435	COG2860	membrane
D1J63_RS19440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1J63_RS19440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1J63_RS19470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1J63_RS19480	COG0579	oxidoreductase
D1J63_RS19515	COG1252	NADH dehydrogenase
D1J63_RS19530	COG1846	Transcriptional regulator
D1J63_RS19555	COG2197	response regulator
D1J63_RS19560	COG4585	Histidine kinase
D1J63_RS19600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1J63_RS19620	COG0739	heme binding
D1J63_RS19620	COG0741	lytic transglycosylase activity
D1J63_RS19620	COG1196	nuclear chromosome segregation
D1J63_RS19625	COG0671	phosphoesterase, PA-phosphatase related
D1J63_RS19630	COG0277	FAD linked oxidase domain protein
D1J63_RS19640	COG1937	Protein conserved in bacteria
D1J63_RS19650	COG0306	phosphate transporter
D1J63_RS19655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1J63_RS19675	COG0494	nUDIX hydrolase
D1J63_RS19675	COG0406	alpha-ribazole phosphatase activity
D1J63_RS19685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1J63_RS19715	COG0456	acetyltransferase
D1J63_RS19720	COG0737	Belongs to the 5'-nucleotidase family
D1J63_RS19725	COG1733	regulation of RNA biosynthetic process
D1J63_RS19740	COG0745	RESPONSE REGULATOR receiver
D1J63_RS19745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J63_RS19750	COG1609	Transcriptional regulator
D1J63_RS19755	COG0745	RESPONSE REGULATOR receiver
D1J63_RS19785	COG2897	thiosulfate sulfurtransferase activity
D1J63_RS19805	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS19850	COG3485	protocatechuate 3,4-dioxygenase
D1J63_RS19855	COG0735	belongs to the Fur family
D1J63_RS19860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1J63_RS19865	COG1490	D-aminoacyl-tRNA deacylase activity
D1J63_RS19880	COG4552	Acetyltransferase involved in intracellular survival and related
D1J63_RS19895	COG2188	Transcriptional regulator
D1J63_RS19905	COG0546	phosphoglycolate phosphatase activity
D1J63_RS19955	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS19980	COG0588	phosphoglycerate mutase activity
D1J63_RS19990	COG2255	four-way junction helicase activity
D1J63_RS20005	COG2188	Transcriptional regulator
D1J63_RS20035	COG2207	Transcriptional regulator
D1J63_RS20035	COG3708	Transcriptional regulator
D1J63_RS20060	COG5002	protein histidine kinase activity
D1J63_RS20080	COG1329	Transcriptional regulator
D1J63_RS20090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1J63_RS20095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1J63_RS20100	COG0215	cysteine-tRNA ligase activity
D1J63_RS20125	COG3842	ATPase activity
D1J63_RS20135	COG0596	Alpha beta hydrolase
D1J63_RS20220	COG0464	growth
D1J63_RS20240	COG1672	PFAM Archaeal ATPase
D1J63_RS20240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J63_RS20290	COG1309	transcriptional regulator
D1J63_RS20300	COG0494	nUDIX hydrolase
D1J63_RS20320	COG2197	response regulator
D1J63_RS20375	COG1940	carbohydrate kinase activity
D1J63_RS20400	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D1J63_RS20410	COG0463	Glycosyl transferase, family 2
D1J63_RS20425	COG1278	Cold shock
D1J63_RS20430	COG0459	protein refolding
D1J63_RS20470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1J63_RS20515	COG3973	AAA domain
D1J63_RS20525	COG1061	Type III restriction enzyme res subunit
D1J63_RS20560	COG1278	Cold shock
D1J63_RS20565	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1J63_RS20570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1J63_RS20580	COG2814	Major facilitator Superfamily
D1J63_RS20595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1J63_RS20605	COG2252	PERMEase
D1J63_RS20635	COG0667	Aldo Keto reductase
D1J63_RS20680	COG2197	response regulator
D1J63_RS20750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1J63_RS20755	COG0247	lactate metabolic process
D1J63_RS20755	COG0277	FAD linked oxidase domain protein
D1J63_RS20790	COG1733	regulation of RNA biosynthetic process
D1J63_RS20795	COG0596	Alpha beta hydrolase
D1J63_RS20800	COG2318	DinB family
D1J63_RS20830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J63_RS20830	COG0515	serine threonine protein kinase
D1J63_RS20845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J63_RS20860	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS20880	COG0259	pyridoxamine-phosphate oxidase activity
D1J63_RS20900	COG4821	SIS domain
D1J63_RS20910	COG0596	Alpha beta hydrolase
D1J63_RS20910	COG2945	thiolester hydrolase activity
D1J63_RS20920	COG1131	(ABC) transporter
D1J63_RS20980	COG1595	DNA-templated transcription, initiation
D1J63_RS20985	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J63_RS21010	COG2271	Major facilitator Superfamily
D1J63_RS21020	COG2072	flavoprotein involved in K transport
D1J63_RS21030	COG0259	pyridoxamine-phosphate oxidase activity
D1J63_RS21040	COG1309	transcriptional regulator
D1J63_RS21050	COG0515	serine threonine protein kinase
D1J63_RS21050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1J63_RS21065	COG3903	Transcriptional regulator
D1J63_RS21065	COG3629	intracellular signal transduction
D1J63_RS21085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1J63_RS21150	COG1686	Belongs to the peptidase S11 family
D1J63_RS21175	COG0386	Belongs to the glutathione peroxidase family
D1J63_RS21200	COG0110	maltose O-acetyltransferase activity
D1J63_RS21205	COG4257	antibiotic catabolic process
D1J63_RS21210	COG1309	transcriptional regulator
D1J63_RS21215	COG0477	Major facilitator Superfamily
D1J63_RS21220	COG4941	Belongs to the sigma-70 factor family
D1J63_RS21225	COG3795	YCII-related domain
D1J63_RS21240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1J63_RS21255	COG4585	Histidine kinase
D1J63_RS21290	COG2188	Transcriptional regulator
D1J63_RS21375	COG0582	viral genome integration into host DNA
D1J63_RS21395	COG1414	Transcriptional regulator
D1J63_RS21415	COG1846	Transcriptional regulator
D1J63_RS21420	COG3384	dioxygenase
D1J63_RS21425	COG1247	-acetyltransferase
D1J63_RS21430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1J63_RS21445	COG0477	Major facilitator Superfamily
D1J63_RS21450	COG1349	DNA-binding transcription factor activity
D1J63_RS21460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1J63_RS21460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1J63_RS21460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1J63_RS21490	COG1970	mechanosensitive ion channel activity
D1J63_RS21500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1J63_RS21525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1J63_RS21530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1J63_RS21540	COG0315	cyclic pyranopterin monophosphate synthase activity
D1J63_RS21545	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1J63_RS21545	COG0315	cyclic pyranopterin monophosphate synthase activity
D1J63_RS21550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J63_RS21570	COG0708	Exodeoxyribonuclease III
D1J63_RS21580	COG2072	flavoprotein involved in K transport
D1J63_RS21585	COG2267	carboxylic ester hydrolase activity
D1J63_RS21615	COG2409	Drug exporters of the RND superfamily
D1J63_RS21620	COG0442	prolyl-tRNA aminoacylation
D1J63_RS21635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1J63_RS21640	COG1122	ATPase activity
D1J63_RS21650	COG0310	cobalt ion transport
D1J63_RS21690	COG0084	hydrolase, TatD family'
D1J63_RS21695	COG1388	LysM domain
D1J63_RS21700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1J63_RS21705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1J63_RS21710	COG0488	(ABC) transporter
D1J63_RS21750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1J63_RS21765	COG2197	response regulator
D1J63_RS21775	COG4106	trans-aconitate 2-methyltransferase activity
D1J63_RS21785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J63_RS21790	COG1309	transcriptional regulator
D1J63_RS21800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1J63_RS21810	COG0193	aminoacyl-tRNA hydrolase activity
D1J63_RS21815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1J63_RS21820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1J63_RS21825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1J63_RS21845	COG4585	Histidine kinase
D1J63_RS21875	COG1136	(ABC) transporter
D1J63_RS21880	COG0577	efflux transmembrane transporter activity
D1J63_RS21950	COG0148	phosphopyruvate hydratase activity
D1J63_RS21970	COG1252	NADH dehydrogenase
D1J63_RS21975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1J63_RS21980	COG1136	(ABC) transporter
D1J63_RS21980	COG0577	efflux transmembrane transporter activity
D1J63_RS21985	COG1136	(ABC) transporter
D1J63_RS22025	COG0183	Belongs to the thiolase family
D1J63_RS22030	COG2755	lipolytic protein G-D-S-L family
D1J63_RS22060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1J63_RS22065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J63_RS22075	COG1228	amidohydrolase
D1J63_RS22085	COG1191	sigma factor activity
D1J63_RS22090	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J63_RS22110	COG3104	oligopeptide transport
D1J63_RS22115	COG0745	RESPONSE REGULATOR receiver
D1J63_RS22120	COG2205	protein histidine kinase activity
D1J63_RS22135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1J63_RS22160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1J63_RS22180	COG1316	TRANSCRIPTIONal
D1J63_RS22195	COG1316	TRANSCRIPTIONal
D1J63_RS22200	COG1316	TRANSCRIPTIONal
D1J63_RS22205	COG1316	TRANSCRIPTIONal
D1J63_RS22210	COG1316	TRANSCRIPTIONal
D1J63_RS22215	COG1316	TRANSCRIPTIONal
D1J63_RS22240	COG0778	Nitroreductase
D1J63_RS22240	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D1J63_RS22245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1J63_RS22285	COG1620	l-lactate permease
D1J63_RS22290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1J63_RS22295	COG2835	tetraacyldisaccharide 4'-kinase activity
D1J63_RS22305	COG1482	cell wall glycoprotein biosynthetic process
D1J63_RS22320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1J63_RS22365	COG0714	Associated with various cellular activities
D1J63_RS22390	COG0745	RESPONSE REGULATOR receiver
D1J63_RS22395	COG5000	phosphorelay sensor kinase activity
D1J63_RS22395	COG5002	protein histidine kinase activity
D1J63_RS22400	COG0823	Involved in the tonB-independent uptake of proteins
D1J63_RS22415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1J63_RS22420	COG2197	response regulator
D1J63_RS22425	COG3214	Protein conserved in bacteria
D1J63_RS22435	COG0653	protein targeting
D1J63_RS22465	COG2902	Dehydrogenase
D1J63_RS22470	COG1216	Glycosyl transferase, family 2
D1J63_RS22475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J63_RS22480	COG1134	teichoic acid transport
D1J63_RS22510	COG1846	Transcriptional regulator
D1J63_RS22515	COG1764	response to oxidative stress
D1J63_RS22530	COG1216	Glycosyl transferase, family 2
D1J63_RS22535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J63_RS22540	COG1216	Glycosyl transferase, family 2
D1J63_RS22545	COG0395	ABC-type sugar transport system, permease component
D1J63_RS22550	COG1175	transmembrane transport
D1J63_RS22560	COG1674	ftsk spoiiie
D1J63_RS22565	COG0515	serine threonine protein kinase
D1J63_RS22570	COG0515	serine threonine protein kinase
D1J63_RS22575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1J63_RS22590	COG2884	Cell division ATP-binding protein ftsE
D1J63_RS22600	COG0793	Belongs to the peptidase S41A family
D1J63_RS22605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1J63_RS22620	COG0583	DNA-binding transcription factor activity
D1J63_RS22645	COG2223	nitrite transmembrane transporter activity
D1J63_RS22675	COG3973	AAA domain
D1J63_RS22685	COG0776	regulation of translation
D1J63_RS22690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1J63_RS22695	COG1678	Uncharacterized ACR, COG1678
D1J63_RS22710	COG1175	transmembrane transport
D1J63_RS22715	COG0395	ABC-type sugar transport system, permease component
D1J63_RS22720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1J63_RS22735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J63_RS22765	COG3480	Lon protease (S16) C-terminal proteolytic domain
D1J63_RS22775	COG1174	glycine betaine transport
D1J63_RS22795	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1J63_RS22805	COG0277	FAD linked oxidase domain protein
D1J63_RS22825	COG1714	RDD family
D1J63_RS22845	COG1335	isochorismatase
D1J63_RS22855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1J63_RS22870	COG1113	amino acid transport
D1J63_RS22900	COG1234	tRNA 3'-trailer cleavage
D1J63_RS22905	COG1263	PTS System
D1J63_RS22910	COG1263	PTS System
D1J63_RS22915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1J63_RS22920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1J63_RS22930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1J63_RS22960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1J63_RS22980	COG4555	ABC transporter
D1J63_RS22995	COG2733	membrane
D1J63_RS23020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1J63_RS23060	COG0702	epimerase
D1J63_RS23070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J63_RS23145	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1J63_RS23175	COG4702	Belongs to the UPF0303 family
D1J63_RS23180	COG0673	inositol 2-dehydrogenase activity
D1J63_RS23205	COG0583	DNA-binding transcription factor activity
D1J63_RS23240	COG3397	chitin binding
D1J63_RS23255	COG1126	abc transporter atp-binding protein
D1J63_RS23260	COG0765	amino acid transport
D1J63_RS23265	COG0765	amino acid transport
D1J63_RS23270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J63_RS23285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1J63_RS23330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J63_RS23340	COG4106	trans-aconitate 2-methyltransferase activity
D1J63_RS23390	COG0477	Major facilitator Superfamily
D1J63_RS23395	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS23410	COG2267	carboxylic ester hydrolase activity
D1J63_RS23420	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS23450	COG1846	Transcriptional regulator
D1J63_RS23490	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1J63_RS23500	COG0745	RESPONSE REGULATOR receiver
D1J63_RS23505	COG2205	protein histidine kinase activity
D1J63_RS23520	COG0395	ABC-type sugar transport system, permease component
D1J63_RS23545	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1J63_RS23550	COG4977	sequence-specific DNA binding
D1J63_RS23560	COG0589	response to stress
D1J63_RS23565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1J63_RS23595	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1J63_RS23615	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS23630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1J63_RS23635	COG1309	transcriptional regulator
D1J63_RS23645	COG1946	Acyl-CoA thioesterase
D1J63_RS23660	COG0028	Belongs to the TPP enzyme family
D1J63_RS23675	COG2356	endonuclease I
D1J63_RS23710	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J63_RS23735	COG1609	Transcriptional regulator
D1J63_RS23740	COG0673	inositol 2-dehydrogenase activity
D1J63_RS23755	COG1869	D-ribose catabolic process
D1J63_RS23760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J63_RS23765	COG1879	ABC-type sugar transport system periplasmic component
D1J63_RS23770	COG1129	ABC transporter
D1J63_RS23785	COG1595	DNA-templated transcription, initiation
D1J63_RS23790	COG0640	Transcriptional regulator
D1J63_RS23825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1J63_RS23850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1J63_RS23880	COG1131	(ABC) transporter
D1J63_RS23940	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS23960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1J63_RS23995	COG2304	oxidoreductase activity
D1J63_RS24010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1J63_RS24020	COG2814	Major facilitator Superfamily
D1J63_RS24035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1J63_RS24055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1J63_RS24060	COG0629	single-stranded DNA binding
D1J63_RS24075	COG3415	Transposase
D1J63_RS24075	COG2801	Transposase and inactivated derivatives
D1J63_RS24085	COG0657	acetylesterase activity
D1J63_RS24110	COG0577	efflux transmembrane transporter activity
D1J63_RS24110	COG1136	(ABC) transporter
D1J63_RS24130	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1J63_RS24160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1J63_RS24175	COG1486	melibiose metabolic process
D1J63_RS24180	COG0395	ABC-type sugar transport system, permease component
D1J63_RS24185	COG1175	transmembrane transport
D1J63_RS24190	COG1653	transport
D1J63_RS24220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J63_RS24250	COG1136	(ABC) transporter
D1J63_RS24260	COG4106	trans-aconitate 2-methyltransferase activity
D1J63_RS24290	COG0668	transmembrane transport
D1J63_RS24295	COG1846	Transcriptional regulator
D1J63_RS24300	COG0697	spore germination
D1J63_RS24360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1J63_RS24365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1J63_RS24375	COG1268	BioY protein
D1J63_RS24380	COG1113	amino acid transport
D1J63_RS24385	COG0698	ribose 5-phosphate isomerase
D1J63_RS24395	COG4552	Acetyltransferase involved in intracellular survival and related
D1J63_RS24410	COG3594	Acyltransferase
D1J63_RS24430	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1J63_RS24435	COG0740	serine-type endopeptidase activity
D1J63_RS24440	COG0740	serine-type endopeptidase activity
D1J63_RS24445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1J63_RS24455	COG0525	valine-tRNA ligase activity
D1J63_RS24460	COG0285	dihydrofolate synthase activity
D1J63_RS24470	COG0105	UTP biosynthetic process
D1J63_RS24475	COG1077	Cell shape determining protein MreB Mrl
D1J63_RS24490	COG0768	penicillin binding
D1J63_RS24495	COG0772	Belongs to the SEDS family
D1J63_RS24515	COG1530	ribonuclease E activity
D1J63_RS24520	COG0371	Dehydrogenase
D1J63_RS24525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1J63_RS24530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1J63_RS24535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1J63_RS24540	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS24545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J63_RS24550	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1J63_RS24560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1J63_RS24570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1J63_RS24585	COG0501	Belongs to the peptidase M48B family
D1J63_RS24600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1J63_RS24610	COG0799	negative regulation of ribosome biogenesis
D1J63_RS24615	COG0588	phosphoglycerate mutase activity
D1J63_RS24640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1J63_RS24650	COG0495	leucyl-tRNA aminoacylation
D1J63_RS24660	COG1307	EDD domain protein, DegV family
D1J63_RS24665	COG1555	photosystem II stabilization
D1J63_RS24670	COG1234	tRNA 3'-trailer cleavage
D1J63_RS24690	COG2353	YceI-like domain
D1J63_RS24705	COG0268	Binds directly to 16S ribosomal RNA
D1J63_RS24710	COG0481	GTPase activity
D1J63_RS24740	COG1420	regulation of RNA biosynthetic process
D1J63_RS24745	COG0484	heat shock protein binding
D1J63_RS24770	COG4946	Tricorn protease homolog
D1J63_RS24770	COG0793	Belongs to the peptidase S41A family
D1J63_RS24780	COG0537	adenosine 5'-monophosphoramidase activity
D1J63_RS24785	COG1234	tRNA 3'-trailer cleavage
D1J63_RS24790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J63_RS24800	COG1414	Transcriptional regulator
D1J63_RS24805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J63_RS24810	COG4948	Mandelate Racemase Muconate Lactonizing
D1J63_RS24820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J63_RS24825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1J63_RS24845	COG2315	Protein conserved in bacteria
D1J63_RS24855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1J63_RS24880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1J63_RS24915	COG2409	Drug exporters of the RND superfamily
D1J63_RS24920	COG4585	Histidine kinase
D1J63_RS24925	COG2197	response regulator
D1J63_RS24970	COG1381	Involved in DNA repair and RecF pathway recombination
D1J63_RS24975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1J63_RS24990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1J63_RS24995	COG1121	(ABC) transporter
D1J63_RS25000	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1J63_RS25000	COG3443	Belongs to the bacterial solute-binding protein 9 family
D1J63_RS25005	COG0423	glycine-tRNA ligase activity
D1J63_RS25015	COG0477	Major facilitator Superfamily
D1J63_RS25055	COG0574	Belongs to the PEP-utilizing enzyme family
D1J63_RS25055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1J63_RS25060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D1J63_RS25080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1J63_RS25080	COG2146	nitrite reductase [NAD(P)H] activity
D1J63_RS25130	COG0243	molybdopterin cofactor binding
D1J63_RS25135	COG2949	membrane
D1J63_RS25145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1J63_RS25155	COG0358	DNA primase activity
D1J63_RS25160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1J63_RS25175	COG1070	Carbohydrate kinase
D1J63_RS25210	COG1404	Belongs to the peptidase S8 family
D1J63_RS25215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1J63_RS25215	COG0825	malonyl-CoA metabolic process
D1J63_RS25220	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS25230	COG2186	Transcriptional regulator
D1J63_RS25240	COG1414	Transcriptional regulator
D1J63_RS25245	COG3386	PFAM SMP-30 Gluconolaconase
D1J63_RS25275	COG1175	transmembrane transport
D1J63_RS25280	COG0395	ABC-type sugar transport system, permease component
D1J63_RS25340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D1J63_RS25345	COG3507	Belongs to the glycosyl hydrolase 43 family
D1J63_RS25370	COG1127	ABC transporter
D1J63_RS25380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1J63_RS25405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1J63_RS25440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1J63_RS25450	COG4214	carbohydrate transport
D1J63_RS25455	COG1129	ABC transporter
D1J63_RS25495	COG2130	NADP-dependent
D1J63_RS25500	COG1764	response to oxidative stress
D1J63_RS25530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1J63_RS25535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J63_RS25540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS25545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J63_RS25570	COG3693	PFAM glycoside hydrolase, family 10
D1J63_RS25590	COG0789	Transcriptional regulator
D1J63_RS25595	COG0667	Aldo Keto reductase
D1J63_RS25610	COG1309	transcriptional regulator
D1J63_RS25615	COG0477	Major facilitator Superfamily
D1J63_RS25625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1J63_RS25675	COG1358	cellular component organization or biogenesis
D1J63_RS25685	COG0586	Pfam SNARE associated Golgi protein
D1J63_RS25690	COG4585	Histidine kinase
D1J63_RS25800	COG4122	O-methyltransferase activity
D1J63_RS25830	COG3409	Peptidoglycan-binding domain 1 protein
D1J63_RS25885	COG3845	ABC transporter
D1J63_RS25900	COG1657	PFAM Prenyltransferase squalene oxidase
D1J63_RS25910	COG1309	transcriptional regulator
D1J63_RS25915	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS25940	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1J63_RS25950	COG0477	Major facilitator Superfamily
D1J63_RS25960	COG2197	response regulator
D1J63_RS25965	COG4585	Histidine kinase
D1J63_RS25975	COG1131	(ABC) transporter
D1J63_RS25980	COG2030	dehydratase
D1J63_RS25995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1J63_RS26010	COG0800	Aldolase
D1J63_RS26015	COG3022	response to hydroperoxide
D1J63_RS26065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1J63_RS26090	COG2319	Wd-40 repeat
D1J63_RS26090	COG4249	Peptidase C14 caspase catalytic subunit p20
D1J63_RS26175	COG1280	lysine exporter protein (LysE YggA)
D1J63_RS26190	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS26235	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS26240	COG3540	Alkaline phosphatase
D1J63_RS26250	COG2814	Major facilitator Superfamily
D1J63_RS26255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1J63_RS26270	COG2197	response regulator
D1J63_RS26290	COG0672	)-iron permease
D1J63_RS26295	COG2837	iron assimilation
D1J63_RS26305	COG1120	ATPase activity
D1J63_RS26310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J63_RS26335	COG0384	phenazine biosynthesis protein PhzF
D1J63_RS26375	COG1994	Peptidase M50
D1J63_RS26395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1J63_RS26405	COG2814	Major facilitator Superfamily
D1J63_RS26435	COG0174	glutamine synthetase
D1J63_RS26455	COG2161	toxin-antitoxin pair type II binding
D1J63_RS26465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1J63_RS26475	COG1609	Transcriptional regulator
D1J63_RS26485	COG1175	transmembrane transport
D1J63_RS26490	COG3833	ABC-type maltose transport systems, permease component
D1J63_RS26495	COG0366	Alpha amylase catalytic
D1J63_RS26515	COG1309	transcriptional regulator
D1J63_RS26545	COG2197	response regulator
D1J63_RS26560	COG0745	RESPONSE REGULATOR receiver
D1J63_RS26620	COG0501	Belongs to the peptidase M48B family
D1J63_RS26625	COG1733	regulation of RNA biosynthetic process
D1J63_RS26630	COG0702	epimerase
D1J63_RS26640	COG0174	glutamine synthetase
D1J63_RS26660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1J63_RS26665	COG0321	lipoyl(octanoyl) transferase activity
D1J63_RS26720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1J63_RS26730	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J63_RS26735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1J63_RS26740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1J63_RS26750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1J63_RS26765	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1J63_RS26785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1J63_RS26790	COG2226	methyltransferase
D1J63_RS26810	COG4585	Histidine kinase
D1J63_RS26815	COG2197	response regulator
D1J63_RS26820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1J63_RS26830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1J63_RS26855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J63_RS26865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1J63_RS26870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1J63_RS26880	COG1376	ErfK ybiS ycfS ynhG family protein
D1J63_RS26890	COG1845	cytochrome c oxidase, subunit III
D1J63_RS26895	COG2010	Cytochrome c
D1J63_RS26900	COG0723	plastoquinol--plastocyanin reductase activity
D1J63_RS26905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1J63_RS26910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1J63_RS26915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1J63_RS26920	COG1929	Belongs to the glycerate kinase type-1 family
D1J63_RS26930	COG0745	RESPONSE REGULATOR receiver
D1J63_RS26935	COG2205	protein histidine kinase activity
D1J63_RS26985	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS27005	COG0003	Pfam Anion-transporting ATPase
D1J63_RS27015	COG1940	carbohydrate kinase activity
D1J63_RS27040	COG4585	Histidine kinase
D1J63_RS27055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1J63_RS27075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1J63_RS27085	COG2193	ferroxidase activity
D1J63_RS27090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1J63_RS27095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D1J63_RS27100	COG0515	serine threonine protein kinase
D1J63_RS27100	COG2815	serine threonine protein kinase
D1J63_RS27105	COG2022	thiamine diphosphate biosynthetic process
D1J63_RS27115	COG2022	thiamine diphosphate biosynthetic process
D1J63_RS27115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J63_RS27130	COG0352	thiamine-phosphate diphosphorylase activity
D1J63_RS27150	COG1309	transcriptional regulator
D1J63_RS27180	COG0714	Associated with various cellular activities
D1J63_RS27190	COG0275	rRNA processing
D1J63_RS27200	COG0768	penicillin binding
D1J63_RS27205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1J63_RS27210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1J63_RS27215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1J63_RS27220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1J63_RS27230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1J63_RS27235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1J63_RS27245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1J63_RS27250	COG1496	oxidoreductase activity
D1J63_RS27260	COG1799	cell septum assembly
D1J63_RS27270	COG3599	regulation of cell shape
D1J63_RS27275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1J63_RS27285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1J63_RS27300	COG0025	NhaP-type Na H and K H
D1J63_RS27335	COG0587	DNA-directed DNA polymerase activity
D1J63_RS27345	COG1432	Conserved Protein
D1J63_RS27365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1J63_RS27385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1J63_RS27390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1J63_RS27395	COG0131	Imidazoleglycerol-phosphate dehydratase
D1J63_RS27400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1J63_RS27405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1J63_RS27410	COG0251	oxidation-reduction process
D1J63_RS27415	COG0107	imidazoleglycerol-phosphate synthase activity
D1J63_RS27440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1J63_RS27465	COG0134	indole-3-glycerol-phosphate synthase activity
D1J63_RS27475	COG0133	tryptophan synthase activity
D1J63_RS27480	COG0159	tryptophan synthase activity
D1J63_RS27490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1J63_RS27495	COG2301	Belongs to the HpcH HpaI aldolase family
D1J63_RS27500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1J63_RS27530	COG0067	glutamate synthase
D1J63_RS27530	COG0069	glutamate synthase activity
D1J63_RS27530	COG0070	glutamate synthase
D1J63_RS27550	COG2304	oxidoreductase activity
D1J63_RS27555	COG2968	Membrane
D1J63_RS27565	COG1605	Chorismate mutase
D1J63_RS27565	COG0287	Prephenate dehydrogenase
D1J63_RS27585	COG0737	Belongs to the 5'-nucleotidase family
D1J63_RS27640	COG2050	protein possibly involved in aromatic compounds catabolism
D1J63_RS27670	COG1643	Atp-dependent helicase
D1J63_RS27675	COG2226	methyltransferase
D1J63_RS27685	COG0539	negative regulation of cytoplasmic translation
D1J63_RS27695	COG0237	dephospho-CoA kinase activity
D1J63_RS27710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1J63_RS27730	COG2267	carboxylic ester hydrolase activity
D1J63_RS27800	COG2226	methyltransferase
D1J63_RS27810	COG2313	pseudouridylate synthase activity
D1J63_RS27825	COG0584	glycerophosphoryl diester phosphodiesterase
D1J63_RS27835	COG0556	nucleotide-excision repair
D1J63_RS27855	COG0387	Pfam Sodium calcium exchanger
D1J63_RS27860	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1J63_RS27865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1J63_RS27880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1J63_RS27905	COG0322	excinuclease ABC activity
D1J63_RS27910	COG1660	Displays ATPase and GTPase activities
D1J63_RS27915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1J63_RS27920	COG1481	regulation of sporulation
D1J63_RS27935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1J63_RS27940	COG0126	phosphoglycerate kinase activity
D1J63_RS27945	COG0149	triose-phosphate isomerase activity
D1J63_RS27950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1J63_RS27960	COG0166	Belongs to the GPI family
D1J63_RS27970	COG1136	(ABC) transporter
D1J63_RS27975	COG1695	Transcriptional regulator
D1J63_RS27980	COG1653	transport
D1J63_RS27985	COG0366	Alpha amylase catalytic
D1J63_RS27990	COG1653	transport
D1J63_RS27995	COG1175	transmembrane transport
D1J63_RS28000	COG0395	ABC-type sugar transport system, permease component
D1J63_RS28005	COG0363	glucosamine-6-phosphate deaminase activity
D1J63_RS28020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1J63_RS28035	COG0109	protoheme IX farnesyltransferase activity
D1J63_RS28065	COG1131	(ABC) transporter
D1J63_RS28070	COG2746	aminoglycoside 3-N-acetyltransferase activity
D1J63_RS28085	COG0719	Fe-S assembly protein
D1J63_RS28095	COG0396	ATPase activity
D1J63_RS28100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1J63_RS28105	COG0822	iron-sulfur transferase activity
D1J63_RS28110	COG2151	metal-sulfur cluster biosynthetic enzyme
D1J63_RS28115	COG2076	Multidrug Resistance protein
D1J63_RS28120	COG3226	Transcriptional regulator
D1J63_RS28125	COG2171	N-acyltransferase activity
D1J63_RS28140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J63_RS28185	COG1802	Transcriptional regulator
D1J63_RS28195	COG1309	transcriptional regulator
D1J63_RS28210	COG1063	alcohol dehydrogenase
D1J63_RS28230	COG1349	DNA-binding transcription factor activity
D1J63_RS28235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1J63_RS28240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J63_RS28265	COG1802	Transcriptional regulator
D1J63_RS28280	COG1175	transmembrane transport
D1J63_RS28285	COG0395	ABC-type sugar transport system, permease component
D1J63_RS28300	COG3507	Belongs to the glycosyl hydrolase 43 family
D1J63_RS28310	COG2755	lipolytic protein G-D-S-L family
D1J63_RS28315	COG3866	Pectate lyase
D1J63_RS28320	COG4677	pectinesterase activity
D1J63_RS28330	COG3507	Belongs to the glycosyl hydrolase 43 family
D1J63_RS28340	COG1595	DNA-templated transcription, initiation
D1J63_RS28345	COG0768	penicillin binding
D1J63_RS28350	COG2197	response regulator
D1J63_RS28355	COG4585	Histidine kinase
D1J63_RS28370	COG1414	Transcriptional regulator
D1J63_RS28395	COG5285	phytanoyl-CoA dioxygenase
D1J63_RS28400	COG1917	Cupin 2, conserved barrel domain protein
D1J63_RS28405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1J63_RS28410	COG0456	acetyltransferase
D1J63_RS28415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1J63_RS28440	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D1J63_RS28470	COG1797	cobyrinic acid a,c-diamide synthase activity
D1J63_RS28490	COG1492	cobalamin metabolic process
D1J63_RS28495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1J63_RS28510	COG0235	Class ii aldolase
D1J63_RS28530	COG0488	(ABC) transporter
D1J63_RS28545	COG1024	Enoyl-CoA hydratase
D1J63_RS28580	COG3387	PFAM Glycoside hydrolase 15-related
D1J63_RS28605	COG1404	Belongs to the peptidase S8 family
D1J63_RS28615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1J63_RS28620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1J63_RS28640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1J63_RS28655	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS28665	COG2186	Transcriptional regulator
D1J63_RS28690	COG3830	Belongs to the UPF0237 family
D1J63_RS28690	COG0560	Phosphoserine phosphatase
D1J63_RS28700	COG0842	Transport permease protein
D1J63_RS28700	COG1131	(ABC) transporter
D1J63_RS28700	COG1716	ATPase activity
D1J63_RS28710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1J63_RS28715	COG4221	oxidoreductase activity
D1J63_RS28720	COG4585	Histidine kinase
D1J63_RS28725	COG2197	response regulator
D1J63_RS28740	COG1119	ATPase activity
D1J63_RS28760	COG1881	PFAM PEBP family protein
D1J63_RS28770	COG2094	Belongs to the DNA glycosylase MPG family
D1J63_RS28805	COG0647	UMP catabolic process
D1J63_RS28810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J63_RS28815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1J63_RS28820	COG1120	ATPase activity
D1J63_RS28840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1J63_RS28845	COG0497	DNA recombination
D1J63_RS28850	COG0297	glycogen (starch) synthase activity
D1J63_RS28865	COG3387	PFAM Glycoside hydrolase 15-related
D1J63_RS28870	COG0504	CTP synthase activity
D1J63_RS28875	COG0494	nUDIX hydrolase
D1J63_RS28885	COG0686	Belongs to the AlaDH PNT family
D1J63_RS28905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D1J63_RS28910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1J63_RS28915	COG1187	pseudouridine synthase activity
D1J63_RS28930	COG3541	Predicted nucleotidyltransferase
D1J63_RS28955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1J63_RS28965	COG1160	GTP binding
D1J63_RS28990	COG0671	phosphoesterase, PA-phosphatase related
D1J63_RS29000	COG0477	Major facilitator Superfamily
D1J63_RS29010	COG1799	cell septum assembly
D1J63_RS29030	COG4585	Histidine kinase
D1J63_RS29055	COG0587	DNA-directed DNA polymerase activity
D1J63_RS29065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1J63_RS29065	COG0662	Cupin 2, conserved barrel domain protein
D1J63_RS29095	COG2226	methyltransferase
D1J63_RS29110	COG1725	Transcriptional regulator
D1J63_RS29125	COG2755	lipolytic protein G-D-S-L family
D1J63_RS29130	COG1595	DNA-templated transcription, initiation
D1J63_RS29165	COG2188	Transcriptional regulator
D1J63_RS29170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1J63_RS29180	COG1309	transcriptional regulator
D1J63_RS29185	COG0243	molybdopterin cofactor binding
D1J63_RS29190	COG2851	Citrate transporter
D1J63_RS29205	COG3842	ATPase activity
D1J63_RS29225	COG0640	Transcriptional regulator
D1J63_RS29235	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS29280	COG3876	Protein conserved in bacteria
D1J63_RS29315	COG2149	membrane
D1J63_RS29320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1J63_RS29340	COG1063	alcohol dehydrogenase
D1J63_RS29345	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS29355	COG3265	gluconokinase activity
D1J63_RS29365	COG3012	SEC-C Motif Domain Protein
D1J63_RS29375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1J63_RS29405	COG0667	Aldo Keto reductase
D1J63_RS29410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J63_RS29420	COG0598	Magnesium transport protein CorA
D1J63_RS29425	COG0588	phosphoglycerate mutase activity
D1J63_RS29440	COG0215	cysteine-tRNA ligase activity
D1J63_RS29450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1J63_RS29455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1J63_RS29460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1J63_RS29465	COG1414	Transcriptional regulator
D1J63_RS29470	COG0646	methionine synthase
D1J63_RS29470	COG1410	methionine synthase
D1J63_RS29475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1J63_RS29485	COG4166	transmembrane transport
D1J63_RS29490	COG2197	response regulator
D1J63_RS29500	COG0517	IMP dehydrogenase activity
D1J63_RS29500	COG1994	Peptidase M50
D1J63_RS29525	COG1222	aaa ATPase
D1J63_RS29530	COG4122	O-methyltransferase activity
D1J63_RS29545	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1J63_RS29550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1J63_RS29555	COG1609	Transcriptional regulator
D1J63_RS29565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1J63_RS29570	COG0545	Peptidyl-prolyl cis-trans isomerase
D1J63_RS29600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1J63_RS29605	COG0805	protein transport
D1J63_RS29640	COG0564	pseudouridine synthase activity
D1J63_RS29655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1J63_RS29660	COG4175	Glycine betaine
D1J63_RS29660	COG0517	IMP dehydrogenase activity
D1J63_RS29665	COG4176	ABC-type proline glycine betaine transport system permease component
D1J63_RS29690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1J63_RS29700	COG0174	glutamine synthetase
D1J63_RS29705	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS29710	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS29755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1J63_RS29760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1J63_RS29765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1J63_RS29770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1J63_RS29775	COG5002	protein histidine kinase activity
D1J63_RS29780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1J63_RS29785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1J63_RS29785	COG0072	phenylalanine-tRNA ligase activity
D1J63_RS29805	COG1649	PFAM Uncharacterised BCR, COG1649
D1J63_RS29815	COG0697	spore germination
D1J63_RS29845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1J63_RS29850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1J63_RS29855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1J63_RS29860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1J63_RS29865	COG1438	arginine binding
D1J63_RS29900	COG0165	Argininosuccinate lyase
D1J63_RS29915	COG0477	Major facilitator Superfamily
D1J63_RS29920	COG0204	Acyl-transferase
D1J63_RS29920	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS29925	COG0584	glycerophosphoryl diester phosphodiesterase
D1J63_RS29955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1J63_RS29960	COG2011	ABC-type metal ion transport system permease component
D1J63_RS29965	COG1464	Belongs to the NlpA lipoprotein family
D1J63_RS29980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1J63_RS29985	COG1648	precorrin-2 dehydrogenase activity
D1J63_RS29985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1J63_RS30040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1J63_RS30095	COG1175	transmembrane transport
D1J63_RS30100	COG0395	ABC-type sugar transport system, permease component
D1J63_RS30125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1J63_RS30140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1J63_RS30160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1J63_RS30165	COG1560	Kdo2-lipid A biosynthetic process
D1J63_RS30170	COG0438	transferase activity, transferring glycosyl groups
D1J63_RS30180	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1J63_RS30185	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1J63_RS30190	COG0217	transcriptional regulatory protein
D1J63_RS30195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1J63_RS30200	COG0632	four-way junction helicase activity
D1J63_RS30205	COG2255	four-way junction helicase activity
D1J63_RS30215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1J63_RS30220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1J63_RS30225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1J63_RS30230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1J63_RS30235	COG1196	nuclear chromosome segregation
D1J63_RS30240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1J63_RS30250	COG0124	histidyl-tRNA synthetase
D1J63_RS30270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1J63_RS30290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1J63_RS30295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1J63_RS30310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1J63_RS30320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1J63_RS30325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1J63_RS30330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1J63_RS30340	COG0006	proline dipeptidase activity
D1J63_RS30345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1J63_RS30350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1J63_RS30360	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1J63_RS30365	COG0540	Belongs to the ATCase OTCase family
D1J63_RS30370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1J63_RS30380	COG0505	Belongs to the CarA family
D1J63_RS30385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1J63_RS30390	COG0167	dihydroorotate dehydrogenase activity
D1J63_RS30395	COG0284	orotidine-5'-phosphate decarboxylase activity
D1J63_RS30405	COG0194	GDP metabolic process
D1J63_RS30410	COG1758	RNA polymerase activity
D1J63_RS30420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1J63_RS30435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1J63_RS30460	COG0515	serine threonine protein kinase
D1J63_RS30475	COG1653	transport
D1J63_RS30480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1J63_RS30485	COG2390	Transcriptional regulator
D1J63_RS30505	COG0531	amino acid
D1J63_RS30530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1J63_RS30555	COG2233	PERMEase
D1J63_RS30565	COG2223	nitrite transmembrane transporter activity
D1J63_RS30570	COG1846	Transcriptional regulator
D1J63_RS30595	COG3201	nicotinamide mononucleotide transporter
D1J63_RS30600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1J63_RS30600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1J63_RS30605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1J63_RS30610	COG0140	phosphoribosyl-ATP diphosphatase activity
D1J63_RS30615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1J63_RS30665	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS30690	COG0463	Glycosyl transferase, family 2
D1J63_RS30705	COG2270	Major facilitator Superfamily
D1J63_RS30715	COG2364	Membrane
D1J63_RS30750	COG4336	lyase activity
D1J63_RS30755	COG2814	Major facilitator Superfamily
D1J63_RS30785	COG0326	Molecular chaperone. Has ATPase activity
D1J63_RS30805	COG2018	Roadblock/LC7 domain
D1J63_RS30820	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D1J63_RS30835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1J63_RS30845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1J63_RS30880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1J63_RS30905	COG1716	ATPase activity
D1J63_RS30925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1J63_RS30935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1J63_RS30935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1J63_RS30955	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1J63_RS30965	COG1609	Transcriptional regulator
D1J63_RS30995	COG2197	response regulator
D1J63_RS31000	COG4585	Histidine kinase
D1J63_RS31010	COG1136	(ABC) transporter
D1J63_RS31010	COG0577	efflux transmembrane transporter activity
D1J63_RS31050	COG0697	spore germination
D1J63_RS31065	COG0723	plastoquinol--plastocyanin reductase activity
D1J63_RS31105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1J63_RS31120	COG2318	DinB family
D1J63_RS31140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1J63_RS31145	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS31180	COG1968	undecaprenyl-diphosphatase activity
D1J63_RS31195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1J63_RS31230	COG0110	maltose O-acetyltransferase activity
D1J63_RS31250	COG0640	Transcriptional regulator
D1J63_RS31255	COG1832	CoA-binding protein
D1J63_RS31265	COG1739	Uncharacterized protein family UPF0029
D1J63_RS31300	COG0420	3'-5' exonuclease activity
D1J63_RS31305	COG0419	ATPase involved in DNA repair
D1J63_RS31310	COG1522	sequence-specific DNA binding
D1J63_RS31325	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS31340	COG0626	cystathionine gamma-synthase activity
D1J63_RS31365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J63_RS31405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1J63_RS31405	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1J63_RS31415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D1J63_RS31420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1J63_RS31445	COG3320	Male sterility
D1J63_RS31445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS31450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS31455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J63_RS31460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1J63_RS31465	COG0022	dehydrogenase e1 component
D1J63_RS31470	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J63_RS31475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1J63_RS31480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1J63_RS31490	COG0596	Alpha beta hydrolase
D1J63_RS31490	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1J63_RS31495	COG1595	DNA-templated transcription, initiation
D1J63_RS31500	COG2188	Transcriptional regulator
D1J63_RS31505	COG1940	carbohydrate kinase activity
D1J63_RS31510	COG2197	response regulator
D1J63_RS31515	COG4585	Histidine kinase
D1J63_RS31535	COG3663	DNA glycosylase
D1J63_RS31540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1J63_RS31560	COG0456	acetyltransferase
D1J63_RS31580	COG2226	methyltransferase
D1J63_RS31585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1J63_RS31590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1J63_RS31595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1J63_RS31600	COG0156	8-amino-7-oxononanoate synthase activity
D1J63_RS31625	COG0831	urea catabolic process
D1J63_RS31630	COG0832	Belongs to the urease beta subunit family
D1J63_RS31635	COG0804	urea catabolic process
D1J63_RS31645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1J63_RS31650	COG0829	nickel cation binding
D1J63_RS31665	COG0204	Acyl-transferase
D1J63_RS31690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1J63_RS31695	COG1834	amidinotransferase
D1J63_RS31700	COG1522	sequence-specific DNA binding
D1J63_RS31715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1J63_RS31720	COG3275	phosphorelay sensor kinase activity
D1J63_RS31735	COG0205	6-phosphofructokinase activity
D1J63_RS31740	COG3442	glutamine amidotransferase
D1J63_RS31745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1J63_RS31750	COG0242	peptide deformylase activity
D1J63_RS31760	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS31770	COG2124	cytochrome p450
D1J63_RS31775	COG3424	synthase
D1J63_RS31785	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS31795	COG1793	dna ligase
D1J63_RS31805	COG3800	Transcriptional regulator
D1J63_RS31805	COG1396	sequence-specific DNA binding
D1J63_RS31815	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS31820	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS31845	COG0477	Major facilitator Superfamily
D1J63_RS31935	COG0270	DNA (cytosine-5-)-methyltransferase activity
D1J63_RS31945	COG0210	DNA helicase
D1J63_RS31955	COG1012	belongs to the aldehyde dehydrogenase family
D1J63_RS31970	COG1846	Transcriptional regulator
D1J63_RS31970	COG1940	carbohydrate kinase activity
D1J63_RS31975	COG1070	Carbohydrate kinase
D1J63_RS31980	COG2115	Belongs to the xylose isomerase family
D1J63_RS31990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1J63_RS32050	COG2018	Roadblock/LC7 domain
D1J63_RS32060	COG1946	Acyl-CoA thioesterase
D1J63_RS32075	COG0254	rRNA binding
D1J63_RS32085	COG1132	(ABC) transporter
D1J63_RS32105	COG1132	(ABC) transporter
D1J63_RS32140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1J63_RS32155	COG0432	Pfam Uncharacterised protein family UPF0047
D1J63_RS32185	COG3290	protein histidine kinase activity
D1J63_RS32190	COG4565	transcriptional regulatory protein
D1J63_RS32200	COG2080	2 iron, 2 sulfur cluster binding
D1J63_RS32205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D1J63_RS32210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1J63_RS32220	COG3387	PFAM Glycoside hydrolase 15-related
D1J63_RS32235	COG4221	oxidoreductase activity
D1J63_RS32270	COG0546	phosphoglycolate phosphatase activity
D1J63_RS32285	COG2706	6-phosphogluconolactonase activity
D1J63_RS32295	COG2971	BadF BadG BcrA BcrD
D1J63_RS32300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1J63_RS32310	COG1960	acyl-CoA dehydrogenase activity
D1J63_RS32325	COG1902	pentaerythritol trinitrate reductase activity
D1J63_RS32330	COG0640	Transcriptional regulator
D1J63_RS32350	COG1309	transcriptional regulator
D1J63_RS32360	COG0671	phosphoesterase, PA-phosphatase related
D1J63_RS32400	COG0584	glycerophosphoryl diester phosphodiesterase
D1J63_RS32425	COG0204	Acyl-transferase
D1J63_RS32445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1J63_RS32475	COG1660	Displays ATPase and GTPase activities
D1J63_RS32480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J63_RS32490	COG0445	tRNA wobble uridine modification
D1J63_RS32495	COG4585	Histidine kinase
D1J63_RS32500	COG2197	response regulator
D1J63_RS32520	COG0738	Major facilitator superfamily
D1J63_RS32525	COG1609	Transcriptional regulator
D1J63_RS32535	COG1175	transmembrane transport
D1J63_RS32540	COG0395	ABC-type sugar transport system, permease component
D1J63_RS32545	COG3250	beta-galactosidase activity
D1J63_RS32555	COG2723	6-phospho-beta-galactosidase activity
D1J63_RS32560	COG0395	ABC-type sugar transport system, permease component
D1J63_RS32565	COG1175	transmembrane transport
D1J63_RS32575	COG1501	Belongs to the glycosyl hydrolase 31 family
D1J63_RS32590	COG0783	Belongs to the Dps family
D1J63_RS32595	COG0673	inositol 2-dehydrogenase activity
D1J63_RS32615	COG2608	mercury ion transmembrane transporter activity
D1J63_RS32630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1J63_RS32635	COG0191	fructose-bisphosphate aldolase activity
D1J63_RS32640	COG2813	Specifically methylates the guanine in position
D1J63_RS32650	COG1940	carbohydrate kinase activity
D1J63_RS32670	COG3547	Transposase (IS116 IS110 IS902 family)
D1J63_RS32695	COG1136	(ABC) transporter
D1J63_RS32700	COG0577	efflux transmembrane transporter activity
D1J63_RS32715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1J63_RS32725	COG1349	DNA-binding transcription factor activity
D1J63_RS32765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1J63_RS32785	COG3345	alpha-galactosidase
D1J63_RS32800	COG1609	Transcriptional regulator
D1J63_RS32810	COG1175	transmembrane transport
D1J63_RS32820	COG1472	Belongs to the glycosyl hydrolase 3 family
D1J63_RS32835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1J63_RS32845	COG0137	argininosuccinate synthase activity
D1J63_RS32870	COG0444	Belongs to the ABC transporter superfamily
D1J63_RS32875	COG0601	transmembrane transport
D1J63_RS32880	COG0747	negative chemotaxis
D1J63_RS32890	COG3458	cephalosporin-C deacetylase activity
D1J63_RS32900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1J63_RS32905	COG1940	carbohydrate kinase activity
D1J63_RS32910	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D1J63_RS32930	COG0640	Transcriptional regulator
D1J63_RS32935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1J63_RS32940	COG1993	acr, cog1993
D1J63_RS32945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1J63_RS32950	COG1968	undecaprenyl-diphosphatase activity
D1J63_RS32960	COG2066	Belongs to the glutaminase family
D1J63_RS32970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1J63_RS32990	COG2188	Transcriptional regulator
D1J63_RS32995	COG3458	cephalosporin-C deacetylase activity
D1J63_RS33010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1J63_RS33020	COG2890	protein-(glutamine-N5) methyltransferase activity
D1J63_RS33040	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1J63_RS33040	COG1902	pentaerythritol trinitrate reductase activity
D1J63_RS33070	COG1461	Dihydroxyacetone kinase
D1J63_RS33075	COG2376	Dihydroxyacetone kinase
D1J63_RS33090	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D1J63_RS33110	COG2205	protein histidine kinase activity
D1J63_RS33115	COG0745	RESPONSE REGULATOR receiver
D1J63_RS33130	COG1073	alpha beta
D1J63_RS33155	COG0662	Cupin 2, conserved barrel domain protein
D1J63_RS33160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1J63_RS33170	COG0561	phosphatase activity
D1J63_RS33175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1J63_RS33180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1J63_RS33205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1J63_RS33210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1J63_RS33225	COG1609	Transcriptional regulator
D1J63_RS33235	COG1175	transmembrane transport
D1J63_RS33240	COG3833	ABC-type maltose transport systems, permease component
D1J63_RS33245	COG0366	Alpha amylase catalytic
D1J63_RS33295	COG1131	(ABC) transporter
D1J63_RS33300	COG1725	Transcriptional regulator
D1J63_RS33315	COG2197	response regulator
D1J63_RS33320	COG4585	Histidine kinase
D1J63_RS33325	COG2409	Drug exporters of the RND superfamily
D1J63_RS33395	COG0515	serine threonine protein kinase
D1J63_RS33410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1J63_RS33415	COG0318	PFAM AMP-dependent synthetase and ligase
D1J63_RS33460	COG0673	inositol 2-dehydrogenase activity
D1J63_RS33510	COG0667	Aldo Keto reductase
D1J63_RS33515	COG0346	lactoylglutathione lyase activity
D1J63_RS33520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1J63_RS33530	COG0583	DNA-binding transcription factor activity
D1J63_RS33535	COG0667	Aldo Keto reductase
D1J63_RS33570	COG1191	sigma factor activity
D1J63_RS33575	COG1396	sequence-specific DNA binding
D1J63_RS33580	COG0740	serine-type endopeptidase activity
D1J63_RS33585	COG0740	serine-type endopeptidase activity
D1J63_RS33600	COG0328	RNA-DNA hybrid ribonuclease activity
D1J63_RS33610	COG0667	Aldo Keto reductase
D1J63_RS33630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1J63_RS33635	COG0515	serine threonine protein kinase
D1J63_RS33640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1J63_RS33650	COG1672	PFAM Archaeal ATPase
D1J63_RS33650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J63_RS33680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J63_RS33720	COG0477	Major facilitator Superfamily
D1J63_RS33730	COG1982	Orn Lys Arg decarboxylase major
D1J63_RS33770	COG1252	NADH dehydrogenase
D1J63_RS33785	COG2172	sigma factor antagonist activity
D1J63_RS33790	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J63_RS33795	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J63_RS33810	COG2205	protein histidine kinase activity
D1J63_RS33810	COG0784	Response regulator, receiver
D1J63_RS33810	COG5002	protein histidine kinase activity
D1J63_RS33840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1J63_RS33845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1J63_RS33890	COG1191	sigma factor activity
D1J63_RS33900	COG0181	hydroxymethylbilane synthase activity
D1J63_RS33910	COG1793	dna ligase
D1J63_RS33910	COG3285	dna ligase
D1J63_RS33935	COG2208	phosphoserine phosphatase activity
D1J63_RS33945	COG0656	L-ascorbic acid biosynthetic process
D1J63_RS33960	COG0009	L-threonylcarbamoyladenylate synthase
D1J63_RS34000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D1J63_RS34015	COG1088	dTDP-glucose 4,6-dehydratase activity
D1J63_RS34030	COG0456	acetyltransferase
D1J63_RS34065	COG2124	cytochrome p450
D1J63_RS34075	COG0475	glutathione-regulated potassium exporter activity
D1J63_RS34100	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS34150	COG1120	ATPase activity
D1J63_RS34175	COG0110	maltose O-acetyltransferase activity
D1J63_RS34195	COG0395	ABC-type sugar transport system, permease component
D1J63_RS34200	COG4209	transmembrane transport
D1J63_RS34210	COG0028	Belongs to the TPP enzyme family
D1J63_RS34215	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS34240	COG2814	Major facilitator Superfamily
D1J63_RS34250	COG1959	2 iron, 2 sulfur cluster binding
D1J63_RS34275	COG5640	endopeptidase activity
D1J63_RS34280	COG0583	DNA-binding transcription factor activity
D1J63_RS34290	COG2814	Major facilitator Superfamily
D1J63_RS34305	COG0583	DNA-binding transcription factor activity
D1J63_RS34310	COG3340	Belongs to the peptidase S51 family
D1J63_RS34325	COG2124	cytochrome p450
D1J63_RS34380	COG1335	isochorismatase
D1J63_RS34395	COG1119	ATPase activity
D1J63_RS34405	COG5640	endopeptidase activity
D1J63_RS34455	COG2050	protein possibly involved in aromatic compounds catabolism
D1J63_RS34460	COG3396	Phenylacetate-CoA oxygenase
D1J63_RS34465	COG3460	Phenylacetate-CoA oxygenase
D1J63_RS34470	COG3396	Phenylacetate-CoA oxygenase
D1J63_RS34475	COG2151	metal-sulfur cluster biosynthetic enzyme
D1J63_RS34480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1J63_RS34530	COG1953	Uracil, thiamine, allantoin
D1J63_RS34545	COG1175	transmembrane transport
D1J63_RS34550	COG0395	ABC-type sugar transport system, permease component
D1J63_RS34560	COG2175	clavaminate synthase activity
D1J63_RS34585	COG4977	sequence-specific DNA binding
D1J63_RS34590	COG2755	lipolytic protein G-D-S-L family
D1J63_RS34600	COG0326	Molecular chaperone. Has ATPase activity
D1J63_RS34605	COG2391	methyltransferase activity
D1J63_RS34610	COG3226	Transcriptional regulator
D1J63_RS34625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1J63_RS34660	COG2409	Drug exporters of the RND superfamily
D1J63_RS34665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1J63_RS34675	COG0517	IMP dehydrogenase activity
D1J63_RS34675	COG0516	GMP reductase activity
D1J63_RS34710	COG3119	arylsulfatase activity
D1J63_RS34715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1J63_RS34720	COG0584	glycerophosphoryl diester phosphodiesterase
D1J63_RS34755	COG0395	ABC-type sugar transport system, permease component
D1J63_RS34770	COG1051	belongs to the nudix hydrolase family
D1J63_RS34775	COG0584	glycerophosphoryl diester phosphodiesterase
D1J63_RS34785	COG1366	Belongs to the anti-sigma-factor antagonist family
D1J63_RS34830	COG3250	beta-galactosidase activity
D1J63_RS34830	COG5297	Belongs to the glycosyl hydrolase family 6
D1J63_RS34870	COG0667	Aldo Keto reductase
D1J63_RS34875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1J63_RS34880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1J63_RS34895	COG1737	Transcriptional regulator
D1J63_RS34900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1J63_RS34910	COG0154	amidase activity
D1J63_RS34915	COG1309	transcriptional regulator
D1J63_RS34960	COG2353	YceI-like domain
D1J63_RS34985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1J63_RS34990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1J63_RS35005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1J63_RS35065	COG0302	gtp cyclohydrolase
D1J63_RS35075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1J63_RS35085	COG4948	Mandelate Racemase Muconate Lactonizing
D1J63_RS35095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1J63_RS35125	COG2197	response regulator
D1J63_RS35130	COG4585	Histidine kinase
D1J63_RS35165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1J63_RS35180	COG0488	(ABC) transporter
D1J63_RS35190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1J63_RS35200	COG0366	Alpha amylase catalytic
D1J63_RS35200	COG1470	cell adhesion involved in biofilm formation
D1J63_RS35205	COG1609	Transcriptional regulator
D1J63_RS35210	COG2186	Transcriptional regulator
D1J63_RS35215	COG4948	Mandelate Racemase Muconate Lactonizing
D1J63_RS35220	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS35230	COG3618	amidohydrolase
D1J63_RS35240	COG0154	amidase activity
D1J63_RS35260	COG1621	beta-fructofuranosidase activity
D1J63_RS35270	COG1175	transmembrane transport
D1J63_RS35275	COG0395	ABC-type sugar transport system, permease component
D1J63_RS35285	COG1609	Transcriptional regulator
D1J63_RS35305	COG3408	Glycogen debranching enzyme
D1J63_RS35320	COG4221	oxidoreductase activity
D1J63_RS35325	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS35380	COG2205	protein histidine kinase activity
D1J63_RS35385	COG0745	RESPONSE REGULATOR receiver
D1J63_RS35395	COG1131	(ABC) transporter
D1J63_RS35400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1J63_RS35420	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D1J63_RS35440	COG0583	DNA-binding transcription factor activity
D1J63_RS35470	COG1733	regulation of RNA biosynthetic process
D1J63_RS35480	COG3153	acetyltransferase
D1J63_RS35480	COG0456	acetyltransferase
D1J63_RS35510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1J63_RS35520	COG4585	Histidine kinase
D1J63_RS35525	COG2197	response regulator
D1J63_RS35590	COG0667	Aldo Keto reductase
D1J63_RS35595	COG1733	regulation of RNA biosynthetic process
D1J63_RS35615	COG1017	nitric oxide dioxygenase activity
D1J63_RS35615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1J63_RS35675	COG1595	DNA-templated transcription, initiation
D1J63_RS35695	COG1053	succinate dehydrogenase
D1J63_RS35705	COG1764	response to oxidative stress
D1J63_RS35710	COG1595	DNA-templated transcription, initiation
D1J63_RS35750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1J63_RS35770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1J63_RS35790	COG0477	Major facilitator Superfamily
D1J63_RS35820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J63_RS35820	COG1672	PFAM Archaeal ATPase
D1J63_RS35835	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J63_RS35835	COG1672	PFAM Archaeal ATPase
D1J63_RS35865	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J63_RS35865	COG1672	PFAM Archaeal ATPase
D1J63_RS35870	COG1595	DNA-templated transcription, initiation
D1J63_RS35875	COG1846	Transcriptional regulator
D1J63_RS35880	COG0640	Transcriptional regulator
D1J63_RS35905	COG0477	Major facilitator Superfamily
D1J63_RS35910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1J63_RS35930	COG1672	PFAM Archaeal ATPase
D1J63_RS35930	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1J63_RS35985	COG2837	iron assimilation
D1J63_RS36035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1J63_RS36040	COG3321	synthase
D1J63_RS36040	COG0604	alcohol dehydrogenase
D1J63_RS36050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1J63_RS36050	COG2070	2-Nitropropane dioxygenase
D1J63_RS36115	COG0702	epimerase
D1J63_RS36145	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D1J63_RS36150	COG1609	Transcriptional regulator
D1J63_RS36185	COG1309	transcriptional regulator
D1J63_RS36190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1J63_RS36195	COG3507	Belongs to the glycosyl hydrolase 43 family
D1J63_RS36210	COG0726	polysaccharide deacetylase
D1J63_RS36230	COG1028	Short-chain dehydrogenase reductase Sdr
D1J63_RS36245	COG2318	DinB family
D1J63_RS36295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1J63_RS36315	COG0515	serine threonine protein kinase
D1J63_RS36315	COG2815	serine threonine protein kinase
D1J63_RS36360	COG0069	glutamate synthase activity
D1J63_RS36395	COG0640	Transcriptional regulator
D1J63_RS36405	COG1316	TRANSCRIPTIONal
D1J63_RS36410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1J63_RS36435	COG0367	asparagine synthase
D1J63_RS36495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1J63_RS36505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1J63_RS36520	COG0702	epimerase
D1J63_RS36530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity