locus-tag	class	description
F3K22_RS00025	COG0515	serine threonine protein kinase
F3K22_RS00025	COG2815	serine threonine protein kinase
F3K22_RS00130	COG1136	(ABC) transporter
F3K22_RS00130	COG0577	efflux transmembrane transporter activity
F3K22_RS00135	COG2197	response regulator
F3K22_RS00140	COG4585	Histidine kinase
F3K22_RS00155	COG3328	transposase activity
F3K22_RS00160	COG1027	Aspartate ammonia-lyase
F3K22_RS00165	COG0765	amino acid transport
F3K22_RS00170	COG0765	amino acid transport
F3K22_RS00175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3K22_RS00180	COG1126	abc transporter atp-binding protein
F3K22_RS00185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3K22_RS00190	COG4565	transcriptional regulatory protein
F3K22_RS00225	COG1472	Belongs to the glycosyl hydrolase 3 family
F3K22_RS00235	COG1653	transport
F3K22_RS00240	COG1175	transmembrane transport
F3K22_RS00275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3K22_RS00285	COG1733	regulation of RNA biosynthetic process
F3K22_RS00335	COG2311	Membrane
F3K22_RS00385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3K22_RS00400	COG2130	NADP-dependent
F3K22_RS00405	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS00410	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS00430	COG3268	Saccharopine dehydrogenase
F3K22_RS00445	COG0546	phosphoglycolate phosphatase activity
F3K22_RS00455	COG3340	Belongs to the peptidase S51 family
F3K22_RS00460	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS00470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS00540	COG0745	RESPONSE REGULATOR receiver
F3K22_RS00550	COG1742	UPF0060 membrane protein
F3K22_RS00555	COG2186	Transcriptional regulator
F3K22_RS00570	COG0395	ABC-type sugar transport system, permease component
F3K22_RS00585	COG3618	amidohydrolase
F3K22_RS00590	COG1063	alcohol dehydrogenase
F3K22_RS00595	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS00615	COG0028	Belongs to the TPP enzyme family
F3K22_RS00640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F3K22_RS00660	COG1349	DNA-binding transcription factor activity
F3K22_RS00665	COG2223	nitrite transmembrane transporter activity
F3K22_RS00695	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3K22_RS00700	COG0657	acetylesterase activity
F3K22_RS00705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3K22_RS00750	COG2197	response regulator
F3K22_RS00800	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS00815	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F3K22_RS00820	COG1802	Transcriptional regulator
F3K22_RS00830	COG1309	transcriptional regulator
F3K22_RS00835	COG4221	oxidoreductase activity
F3K22_RS00850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3K22_RS00855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F3K22_RS00860	COG2080	2 iron, 2 sulfur cluster binding
F3K22_RS00885	COG2409	Drug exporters of the RND superfamily
F3K22_RS00890	COG4585	Histidine kinase
F3K22_RS00895	COG2197	response regulator
F3K22_RS00900	COG4585	Histidine kinase
F3K22_RS00905	COG2197	response regulator
F3K22_RS00910	COG0726	polysaccharide deacetylase
F3K22_RS00915	COG4249	Peptidase C14 caspase catalytic subunit p20
F3K22_RS00915	COG2319	Wd-40 repeat
F3K22_RS00935	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F3K22_RS00940	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F3K22_RS00955	COG0129	dihydroxy-acid dehydratase activity
F3K22_RS00960	COG1414	Transcriptional regulator
F3K22_RS00965	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3K22_RS00970	COG1063	alcohol dehydrogenase
F3K22_RS01000	COG0515	serine threonine protein kinase
F3K22_RS01025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F3K22_RS01040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F3K22_RS01060	COG1136	(ABC) transporter
F3K22_RS01070	COG2197	response regulator
F3K22_RS01075	COG4585	Histidine kinase
F3K22_RS01095	COG1695	Transcriptional regulator
F3K22_RS01115	COG3693	PFAM glycoside hydrolase, family 10
F3K22_RS01150	COG0833	amino acid
F3K22_RS01160	COG1414	Transcriptional regulator
F3K22_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS01205	COG0251	oxidation-reduction process
F3K22_RS01210	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3K22_RS01245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3K22_RS01250	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS01260	COG0183	Belongs to the thiolase family
F3K22_RS01280	COG1522	sequence-specific DNA binding
F3K22_RS01310	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS01315	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS01320	COG2072	flavoprotein involved in K transport
F3K22_RS01325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F3K22_RS01330	COG1278	Cold shock
F3K22_RS01345	COG0513	Belongs to the DEAD box helicase family
F3K22_RS01350	COG1278	Cold shock
F3K22_RS01355	COG1522	sequence-specific DNA binding
F3K22_RS01360	COG0076	glutamate decarboxylase activity
F3K22_RS01375	COG0800	Aldolase
F3K22_RS01380	COG4948	Mandelate Racemase Muconate Lactonizing
F3K22_RS01385	COG1802	Transcriptional regulator
F3K22_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS01400	COG1175	transmembrane transport
F3K22_RS01405	COG0395	ABC-type sugar transport system, permease component
F3K22_RS01410	COG3250	beta-galactosidase activity
F3K22_RS01425	COG3655	Transcriptional regulator
F3K22_RS01460	COG2045	Belongs to the ComB family
F3K22_RS01510	COG2226	methyltransferase
F3K22_RS01530	COG1846	Transcriptional regulator
F3K22_RS01565	COG1191	sigma factor activity
F3K22_RS01580	COG0784	Response regulator, receiver
F3K22_RS01580	COG5002	protein histidine kinase activity
F3K22_RS01580	COG2205	protein histidine kinase activity
F3K22_RS01585	COG3795	YCII-related domain
F3K22_RS01590	COG4941	Belongs to the sigma-70 factor family
F3K22_RS01600	COG0309	Hydrogenase expression formation protein (HypE)
F3K22_RS01610	COG0298	carbon dioxide binding
F3K22_RS01615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F3K22_RS01620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F3K22_RS01625	COG0375	protein maturation
F3K22_RS01665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F3K22_RS01665	COG1024	Enoyl-CoA hydratase
F3K22_RS01685	COG0739	heme binding
F3K22_RS01715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F3K22_RS01725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F3K22_RS01750	COG3250	beta-galactosidase activity
F3K22_RS01755	COG3250	beta-galactosidase activity
F3K22_RS01770	COG1175	transmembrane transport
F3K22_RS01775	COG1609	Transcriptional regulator
F3K22_RS01810	COG1609	Transcriptional regulator
F3K22_RS01815	COG2814	Major facilitator Superfamily
F3K22_RS01820	COG2267	carboxylic ester hydrolase activity
F3K22_RS01825	COG3250	beta-galactosidase activity
F3K22_RS01835	COG1609	Transcriptional regulator
F3K22_RS01840	COG0747	negative chemotaxis
F3K22_RS01850	COG0444	Belongs to the ABC transporter superfamily
F3K22_RS01855	COG4172	Belongs to the ABC transporter superfamily
F3K22_RS01860	COG3507	Belongs to the glycosyl hydrolase 43 family
F3K22_RS01865	COG1609	Transcriptional regulator
F3K22_RS01875	COG0346	lactoylglutathione lyase activity
F3K22_RS01880	COG0640	Transcriptional regulator
F3K22_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS01910	COG0590	tRNA wobble adenosine to inosine editing
F3K22_RS01925	COG0702	epimerase
F3K22_RS01930	COG1959	2 iron, 2 sulfur cluster binding
F3K22_RS01945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F3K22_RS01975	COG2197	response regulator
F3K22_RS01980	COG2197	response regulator
F3K22_RS01990	COG2197	response regulator
F3K22_RS01995	COG3851	Histidine kinase
F3K22_RS02025	COG1131	(ABC) transporter
F3K22_RS02035	COG4585	Histidine kinase
F3K22_RS02040	COG2197	response regulator
F3K22_RS02050	COG0019	diaminopimelate decarboxylase activity
F3K22_RS02055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3K22_RS02060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3K22_RS02070	COG0456	acetyltransferase
F3K22_RS02075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3K22_RS02085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F3K22_RS02110	COG1191	sigma factor activity
F3K22_RS02130	COG1366	Belongs to the anti-sigma-factor antagonist family
F3K22_RS02135	COG1366	Belongs to the anti-sigma-factor antagonist family
F3K22_RS02140	COG2172	sigma factor antagonist activity
F3K22_RS02190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3K22_RS02200	COG0667	Aldo Keto reductase
F3K22_RS02205	COG0477	Major facilitator Superfamily
F3K22_RS02220	COG0494	nUDIX hydrolase
F3K22_RS02255	COG0328	RNA-DNA hybrid ribonuclease activity
F3K22_RS02290	COG0740	serine-type endopeptidase activity
F3K22_RS02295	COG0740	serine-type endopeptidase activity
F3K22_RS02300	COG1396	sequence-specific DNA binding
F3K22_RS02325	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F3K22_RS02330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F3K22_RS02335	COG1120	ATPase activity
F3K22_RS02340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3K22_RS02360	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F3K22_RS02365	COG1132	(ABC) transporter
F3K22_RS02385	COG0640	Transcriptional regulator
F3K22_RS02390	COG0698	ribose 5-phosphate isomerase
F3K22_RS02405	COG1131	(ABC) transporter
F3K22_RS02405	COG0842	Transport permease protein
F3K22_RS02405	COG1716	ATPase activity
F3K22_RS02425	COG0667	Aldo Keto reductase
F3K22_RS02430	COG0583	DNA-binding transcription factor activity
F3K22_RS02450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3K22_RS02455	COG0346	lactoylglutathione lyase activity
F3K22_RS02485	COG0456	acetyltransferase
F3K22_RS02490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS02495	COG0431	NADPH-dependent FMN reductase
F3K22_RS02500	COG2409	Drug exporters of the RND superfamily
F3K22_RS02505	COG1846	Transcriptional regulator
F3K22_RS02510	COG0702	epimerase
F3K22_RS02600	COG0738	Major facilitator superfamily
F3K22_RS02640	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS02645	COG2366	antibiotic biosynthetic process
F3K22_RS02660	COG2070	2-Nitropropane dioxygenase
F3K22_RS02665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3K22_RS02685	COG3250	beta-galactosidase activity
F3K22_RS02690	COG0395	ABC-type sugar transport system, permease component
F3K22_RS02705	COG1609	Transcriptional regulator
F3K22_RS02715	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS02735	COG0019	diaminopimelate decarboxylase activity
F3K22_RS02750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F3K22_RS02765	COG0640	Transcriptional regulator
F3K22_RS02785	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F3K22_RS02790	COG0310	cobalt ion transport
F3K22_RS02805	COG1122	ATPase activity
F3K22_RS02810	COG3618	amidohydrolase
F3K22_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS02830	COG4948	Mandelate Racemase Muconate Lactonizing
F3K22_RS02835	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3K22_RS02845	COG1129	ABC transporter
F3K22_RS02850	COG4214	carbohydrate transport
F3K22_RS02855	COG2188	Transcriptional regulator
F3K22_RS02870	COG2197	response regulator
F3K22_RS02875	COG4585	Histidine kinase
F3K22_RS02900	COG1132	(ABC) transporter
F3K22_RS02935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F3K22_RS02960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F3K22_RS02985	COG1819	glycosyl
F3K22_RS03005	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS03020	COG0604	alcohol dehydrogenase
F3K22_RS03020	COG3321	synthase
F3K22_RS03045	COG2197	response regulator
F3K22_RS03050	COG2376	Dihydroxyacetone kinase
F3K22_RS03055	COG1461	Dihydroxyacetone kinase
F3K22_RS03080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F3K22_RS03090	COG1902	pentaerythritol trinitrate reductase activity
F3K22_RS03090	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3K22_RS03095	COG2890	protein-(glutamine-N5) methyltransferase activity
F3K22_RS03105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F3K22_RS03120	COG3458	cephalosporin-C deacetylase activity
F3K22_RS03130	COG2226	methyltransferase
F3K22_RS03135	COG0366	Alpha amylase catalytic
F3K22_RS03145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F3K22_RS03150	COG1686	Belongs to the peptidase S11 family
F3K22_RS03160	COG2066	Belongs to the glutaminase family
F3K22_RS03175	COG1113	amino acid transport
F3K22_RS03185	COG1968	undecaprenyl-diphosphatase activity
F3K22_RS03190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F3K22_RS03195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F3K22_RS03220	COG1175	transmembrane transport
F3K22_RS03225	COG0395	ABC-type sugar transport system, permease component
F3K22_RS03235	COG0477	Major facilitator Superfamily
F3K22_RS03260	COG0366	Alpha amylase catalytic
F3K22_RS03270	COG3281	Trehalose synthase
F3K22_RS03275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F3K22_RS03290	COG1846	Transcriptional regulator
F3K22_RS03315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F3K22_RS03335	COG0714	Associated with various cellular activities
F3K22_RS03355	COG1253	flavin adenine dinucleotide binding
F3K22_RS03375	COG1309	transcriptional regulator
F3K22_RS03410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F3K22_RS03415	COG1215	transferase activity, transferring glycosyl groups
F3K22_RS03460	COG1349	DNA-binding transcription factor activity
F3K22_RS03490	COG1940	carbohydrate kinase activity
F3K22_RS03500	COG2813	Specifically methylates the guanine in position
F3K22_RS03515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3K22_RS03520	COG1349	DNA-binding transcription factor activity
F3K22_RS03565	COG0445	tRNA wobble uridine modification
F3K22_RS03575	COG1660	Displays ATPase and GTPase activities
F3K22_RS03600	COG0515	serine threonine protein kinase
F3K22_RS03615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F3K22_RS03640	COG0204	Acyl-transferase
F3K22_RS03665	COG0584	glycerophosphoryl diester phosphodiesterase
F3K22_RS03695	COG0671	phosphoesterase, PA-phosphatase related
F3K22_RS03720	COG0493	'glutamate synthase
F3K22_RS03730	COG3509	depolymerase
F3K22_RS03755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F3K22_RS03785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F3K22_RS03790	COG2151	metal-sulfur cluster biosynthetic enzyme
F3K22_RS03795	COG3396	Phenylacetate-CoA oxygenase
F3K22_RS03800	COG3460	Phenylacetate-CoA oxygenase
F3K22_RS03805	COG3396	Phenylacetate-CoA oxygenase
F3K22_RS03820	COG0531	amino acid
F3K22_RS03850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3K22_RS03885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3K22_RS03890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F3K22_RS03895	COG2080	2 iron, 2 sulfur cluster binding
F3K22_RS03945	COG0714	Associated with various cellular activities
F3K22_RS03955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F3K22_RS03965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3K22_RS03985	COG4166	transmembrane transport
F3K22_RS03995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3K22_RS04000	COG4172	Belongs to the ABC transporter superfamily
F3K22_RS04040	COG1174	glycine betaine transport
F3K22_RS04065	COG3835	regulator
F3K22_RS04080	COG1316	TRANSCRIPTIONal
F3K22_RS04180	COG1595	DNA-templated transcription, initiation
F3K22_RS04195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3K22_RS04200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3K22_RS04265	COG1233	COG1233 Phytoene dehydrogenase and related
F3K22_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS04300	COG0251	oxidation-reduction process
F3K22_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3K22_RS04345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3K22_RS04345	COG0723	plastoquinol--plastocyanin reductase activity
F3K22_RS04355	COG0667	Aldo Keto reductase
F3K22_RS04360	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS04365	COG3608	succinylglutamate desuccinylase aspartoacylase
F3K22_RS04370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3K22_RS04385	COG3842	ATPase activity
F3K22_RS04395	COG3608	succinylglutamate desuccinylase aspartoacylase
F3K22_RS04400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3K22_RS04405	COG1414	Transcriptional regulator
F3K22_RS04410	COG1414	Transcriptional regulator
F3K22_RS04445	COG2197	response regulator
F3K22_RS04480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F3K22_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS04560	COG1131	(ABC) transporter
F3K22_RS04570	COG1595	DNA-templated transcription, initiation
F3K22_RS04580	COG2124	cytochrome p450
F3K22_RS04625	COG4585	Histidine kinase
F3K22_RS04675	COG2267	carboxylic ester hydrolase activity
F3K22_RS04750	COG3629	intracellular signal transduction
F3K22_RS04750	COG3903	Transcriptional regulator
F3K22_RS04775	COG1733	regulation of RNA biosynthetic process
F3K22_RS04785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F3K22_RS04820	COG0432	Pfam Uncharacterised protein family UPF0047
F3K22_RS04825	COG2072	flavoprotein involved in K transport
F3K22_RS04830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F3K22_RS04835	COG1132	(ABC) transporter
F3K22_RS04845	COG1301	dicarboxylic acid transport
F3K22_RS04865	COG1132	(ABC) transporter
F3K22_RS04885	COG1946	Acyl-CoA thioesterase
F3K22_RS04895	COG2018	Roadblock/LC7 domain
F3K22_RS04945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F3K22_RS04970	COG1940	carbohydrate kinase activity
F3K22_RS04985	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS04990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F3K22_RS05025	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS05030	COG0604	alcohol dehydrogenase
F3K22_RS05035	COG2124	cytochrome p450
F3K22_RS05045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS05050	COG0604	alcohol dehydrogenase
F3K22_RS05050	COG3321	synthase
F3K22_RS05055	COG3321	synthase
F3K22_RS05075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3K22_RS05120	COG4948	Mandelate Racemase Muconate Lactonizing
F3K22_RS05125	COG0395	ABC-type sugar transport system, permease component
F3K22_RS05155	COG4213	ABC transporter substrate-binding protein
F3K22_RS05160	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS05165	COG4211	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS05170	COG1129	ABC transporter
F3K22_RS05225	COG0277	FAD linked oxidase domain protein
F3K22_RS05225	COG0247	lactate metabolic process
F3K22_RS05230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F3K22_RS05245	COG1408	metallophosphoesterase
F3K22_RS05260	COG3693	PFAM glycoside hydrolase, family 10
F3K22_RS05270	COG3033	Beta-eliminating lyase
F3K22_RS05315	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS05320	COG1129	ABC transporter
F3K22_RS05325	COG3284	Transcriptional regulator
F3K22_RS05360	COG2755	lipolytic protein G-D-S-L family
F3K22_RS05375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3K22_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS05385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS05385	COG3321	synthase
F3K22_RS05425	COG1846	Transcriptional regulator
F3K22_RS05460	COG0642	Histidine kinase
F3K22_RS05495	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS05500	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS05520	COG1793	dna ligase
F3K22_RS05530	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS05540	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS05550	COG0242	peptide deformylase activity
F3K22_RS05560	COG3442	glutamine amidotransferase
F3K22_RS05565	COG0205	6-phosphofructokinase activity
F3K22_RS05580	COG0515	serine threonine protein kinase
F3K22_RS05580	COG2815	serine threonine protein kinase
F3K22_RS05590	COG3275	phosphorelay sensor kinase activity
F3K22_RS05595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3K22_RS05615	COG1834	amidinotransferase
F3K22_RS05620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3K22_RS05645	COG0829	nickel cation binding
F3K22_RS05650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F3K22_RS05660	COG0804	urea catabolic process
F3K22_RS05665	COG0832	Belongs to the urease beta subunit family
F3K22_RS05670	COG0831	urea catabolic process
F3K22_RS05675	COG1309	transcriptional regulator
F3K22_RS05695	COG0740	serine-type endopeptidase activity
F3K22_RS05735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F3K22_RS05740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3K22_RS05745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F3K22_RS05780	COG0577	efflux transmembrane transporter activity
F3K22_RS05780	COG1136	(ABC) transporter
F3K22_RS05790	COG0456	acetyltransferase
F3K22_RS05815	COG0445	tRNA wobble uridine modification
F3K22_RS05825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F3K22_RS05830	COG3663	DNA glycosylase
F3K22_RS05840	COG1940	carbohydrate kinase activity
F3K22_RS05845	COG2188	Transcriptional regulator
F3K22_RS05850	COG1595	DNA-templated transcription, initiation
F3K22_RS05855	COG2267	carboxylic ester hydrolase activity
F3K22_RS05865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3K22_RS05880	COG0626	cystathionine gamma-synthase activity
F3K22_RS05905	COG1522	sequence-specific DNA binding
F3K22_RS05910	COG0419	ATPase involved in DNA repair
F3K22_RS05915	COG0420	3'-5' exonuclease activity
F3K22_RS05920	COG1739	Uncharacterized protein family UPF0029
F3K22_RS05935	COG1832	CoA-binding protein
F3K22_RS05955	COG0542	response to heat
F3K22_RS05980	COG0110	maltose O-acetyltransferase activity
F3K22_RS06015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F3K22_RS06040	COG1968	undecaprenyl-diphosphatase activity
F3K22_RS06050	COG4106	trans-aconitate 2-methyltransferase activity
F3K22_RS06065	COG0477	Major facilitator Superfamily
F3K22_RS06095	COG0596	Alpha beta hydrolase
F3K22_RS06105	COG3250	beta-galactosidase activity
F3K22_RS06115	COG0395	ABC-type sugar transport system, permease component
F3K22_RS06120	COG1175	transmembrane transport
F3K22_RS06125	COG1653	transport
F3K22_RS06140	COG4585	Histidine kinase
F3K22_RS06165	COG0395	ABC-type sugar transport system, permease component
F3K22_RS06170	COG1175	transmembrane transport
F3K22_RS06180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3K22_RS06190	COG1609	Transcriptional regulator
F3K22_RS06230	COG0395	ABC-type sugar transport system, permease component
F3K22_RS06240	COG1472	Belongs to the glycosyl hydrolase 3 family
F3K22_RS06255	COG3940	Belongs to the glycosyl hydrolase 43 family
F3K22_RS06295	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS06305	COG1024	Enoyl-CoA hydratase
F3K22_RS06360	COG0604	alcohol dehydrogenase
F3K22_RS06360	COG3321	synthase
F3K22_RS06365	COG1309	transcriptional regulator
F3K22_RS06385	COG0577	efflux transmembrane transporter activity
F3K22_RS06385	COG1136	(ABC) transporter
F3K22_RS06390	COG0577	efflux transmembrane transporter activity
F3K22_RS06390	COG1136	(ABC) transporter
F3K22_RS06415	COG2723	6-phospho-beta-galactosidase activity
F3K22_RS06420	COG1609	Transcriptional regulator
F3K22_RS06425	COG1309	transcriptional regulator
F3K22_RS06430	COG1937	Protein conserved in bacteria
F3K22_RS06435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3K22_RS06440	COG0730	response to heat
F3K22_RS06445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3K22_RS06460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3K22_RS06465	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F3K22_RS06470	COG1556	Lactate utilization protein
F3K22_RS06480	COG2409	Drug exporters of the RND superfamily
F3K22_RS06485	COG0745	RESPONSE REGULATOR receiver
F3K22_RS06490	COG2205	protein histidine kinase activity
F3K22_RS06510	COG1968	undecaprenyl-diphosphatase activity
F3K22_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS06590	COG2318	DinB family
F3K22_RS06605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F3K22_RS06650	COG0583	DNA-binding transcription factor activity
F3K22_RS06655	COG0697	spore germination
F3K22_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS06720	COG0384	phenazine biosynthesis protein PhzF
F3K22_RS06745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3K22_RS06745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3K22_RS06755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F3K22_RS06775	COG1716	ATPase activity
F3K22_RS06795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F3K22_RS06825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3K22_RS06835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3K22_RS06870	COG2018	Roadblock/LC7 domain
F3K22_RS06885	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS06890	COG0531	amino acid
F3K22_RS06920	COG2814	Major facilitator Superfamily
F3K22_RS06925	COG4336	lyase activity
F3K22_RS06930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F3K22_RS06935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F3K22_RS06940	COG1984	allophanate hydrolase subunit 2
F3K22_RS06950	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS06980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3K22_RS06985	COG2364	Membrane
F3K22_RS06995	COG2270	Major facilitator Superfamily
F3K22_RS07010	COG1216	Glycosyl transferase, family 2
F3K22_RS07030	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS07040	COG1309	transcriptional regulator
F3K22_RS07080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F3K22_RS07085	COG0140	phosphoribosyl-ATP diphosphatase activity
F3K22_RS07090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F3K22_RS07095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3K22_RS07095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3K22_RS07100	COG3201	nicotinamide mononucleotide transporter
F3K22_RS07110	COG1940	carbohydrate kinase activity
F3K22_RS07110	COG1846	Transcriptional regulator
F3K22_RS07115	COG0738	Major facilitator superfamily
F3K22_RS07155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F3K22_RS07170	COG3842	ATPase activity
F3K22_RS07190	COG2188	Transcriptional regulator
F3K22_RS07200	COG0531	amino acid
F3K22_RS07210	COG2390	Transcriptional regulator
F3K22_RS07215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F3K22_RS07220	COG2409	Drug exporters of the RND superfamily
F3K22_RS07230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F3K22_RS07245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F3K22_RS07255	COG1758	RNA polymerase activity
F3K22_RS07260	COG0194	GDP metabolic process
F3K22_RS07270	COG0284	orotidine-5'-phosphate decarboxylase activity
F3K22_RS07275	COG0167	dihydroorotate dehydrogenase activity
F3K22_RS07280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F3K22_RS07285	COG0505	Belongs to the CarA family
F3K22_RS07295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3K22_RS07300	COG0540	Belongs to the ATCase OTCase family
F3K22_RS07305	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F3K22_RS07315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F3K22_RS07320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F3K22_RS07325	COG0006	proline dipeptidase activity
F3K22_RS07335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F3K22_RS07340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F3K22_RS07345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F3K22_RS07350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3K22_RS07355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F3K22_RS07360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F3K22_RS07365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F3K22_RS07380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F3K22_RS07395	COG0124	histidyl-tRNA synthetase
F3K22_RS07405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F3K22_RS07410	COG1196	nuclear chromosome segregation
F3K22_RS07415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F3K22_RS07425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F3K22_RS07430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3K22_RS07435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3K22_RS07445	COG2255	four-way junction helicase activity
F3K22_RS07450	COG0632	four-way junction helicase activity
F3K22_RS07455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F3K22_RS07460	COG0217	transcriptional regulatory protein
F3K22_RS07465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F3K22_RS07470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F3K22_RS07480	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS07485	COG1560	Kdo2-lipid A biosynthetic process
F3K22_RS07490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F3K22_RS07510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F3K22_RS07515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F3K22_RS07530	COG5002	protein histidine kinase activity
F3K22_RS07530	COG2176	DNA-directed DNA polymerase activity
F3K22_RS07560	COG0395	ABC-type sugar transport system, permease component
F3K22_RS07565	COG1175	transmembrane transport
F3K22_RS07620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F3K22_RS07620	COG0512	Glutamine amidotransferase of anthranilate synthase
F3K22_RS07680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F3K22_RS07680	COG1648	precorrin-2 dehydrogenase activity
F3K22_RS07685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F3K22_RS07700	COG1464	Belongs to the NlpA lipoprotein family
F3K22_RS07705	COG2011	ABC-type metal ion transport system permease component
F3K22_RS07710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F3K22_RS07740	COG0204	Acyl-transferase
F3K22_RS07740	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS07745	COG0477	Major facilitator Superfamily
F3K22_RS07760	COG0165	Argininosuccinate lyase
F3K22_RS07790	COG1438	arginine binding
F3K22_RS07795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3K22_RS07800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F3K22_RS07805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F3K22_RS07810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F3K22_RS07855	COG0697	spore germination
F3K22_RS07865	COG1649	PFAM Uncharacterised BCR, COG1649
F3K22_RS07895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3K22_RS07895	COG0072	phenylalanine-tRNA ligase activity
F3K22_RS07900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F3K22_RS07905	COG5002	protein histidine kinase activity
F3K22_RS07910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3K22_RS07915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F3K22_RS07920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F3K22_RS07925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F3K22_RS07945	COG1404	Belongs to the peptidase S8 family
F3K22_RS07970	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS07975	COG0174	glutamine synthetase
F3K22_RS07980	COG2186	Transcriptional regulator
F3K22_RS07985	COG0531	amino acid
F3K22_RS07990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F3K22_RS08015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3K22_RS08040	COG0564	pseudouridine synthase activity
F3K22_RS08070	COG1309	transcriptional regulator
F3K22_RS08105	COG0805	protein transport
F3K22_RS08110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F3K22_RS08145	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F3K22_RS08155	COG1609	Transcriptional regulator
F3K22_RS08160	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F3K22_RS08165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F3K22_RS08180	COG4122	O-methyltransferase activity
F3K22_RS08185	COG1222	aaa ATPase
F3K22_RS08205	COG0517	IMP dehydrogenase activity
F3K22_RS08205	COG1994	Peptidase M50
F3K22_RS08215	COG2197	response regulator
F3K22_RS08220	COG4166	transmembrane transport
F3K22_RS08225	COG4166	transmembrane transport
F3K22_RS08235	COG1410	methionine synthase
F3K22_RS08235	COG0646	methionine synthase
F3K22_RS08245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F3K22_RS08250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F3K22_RS08255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F3K22_RS08260	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
F3K22_RS08270	COG1129	ABC transporter
F3K22_RS08275	COG1879	ABC-type sugar transport system periplasmic component
F3K22_RS08280	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F3K22_RS08285	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
F3K22_RS08290	COG0235	Class ii aldolase
F3K22_RS08295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F3K22_RS08295	COG0235	Class ii aldolase
F3K22_RS08300	COG2186	Transcriptional regulator
F3K22_RS08315	COG0215	cysteine-tRNA ligase activity
F3K22_RS08330	COG0588	phosphoglycerate mutase activity
F3K22_RS08335	COG0598	Magnesium transport protein CorA
F3K22_RS08345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS08350	COG0667	Aldo Keto reductase
F3K22_RS08395	COG0308	aminopeptidase N
F3K22_RS08400	COG3012	SEC-C Motif Domain Protein
F3K22_RS08405	COG2186	Transcriptional regulator
F3K22_RS08410	COG3265	gluconokinase activity
F3K22_RS08425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F3K22_RS08430	COG3573	Dehydrogenase
F3K22_RS08440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F3K22_RS08445	COG2149	membrane
F3K22_RS08470	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS08485	COG3876	Protein conserved in bacteria
F3K22_RS08510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3K22_RS08510	COG0072	phenylalanine-tRNA ligase activity
F3K22_RS08515	COG0789	Transcriptional regulator
F3K22_RS08545	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS08595	COG2851	Citrate transporter
F3K22_RS08600	COG0243	molybdopterin cofactor binding
F3K22_RS08605	COG1309	transcriptional regulator
F3K22_RS08610	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F3K22_RS08615	COG2188	Transcriptional regulator
F3K22_RS08650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3K22_RS08665	COG1595	DNA-templated transcription, initiation
F3K22_RS08690	COG2755	lipolytic protein G-D-S-L family
F3K22_RS08705	COG1725	Transcriptional regulator
F3K22_RS08740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F3K22_RS08740	COG0662	Cupin 2, conserved barrel domain protein
F3K22_RS08745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F3K22_RS08750	COG0587	DNA-directed DNA polymerase activity
F3K22_RS08795	COG1799	cell septum assembly
F3K22_RS08800	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS08805	COG0477	Major facilitator Superfamily
F3K22_RS08815	COG0671	phosphoesterase, PA-phosphatase related
F3K22_RS08825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F3K22_RS08840	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS08860	COG1137	ATPase activity
F3K22_RS08870	COG3583	domain protein
F3K22_RS08885	COG1160	GTP binding
F3K22_RS08895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F3K22_RS08920	COG3541	Predicted nucleotidyltransferase
F3K22_RS08930	COG0494	nUDIX hydrolase
F3K22_RS08935	COG1187	pseudouridine synthase activity
F3K22_RS08940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F3K22_RS08945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F3K22_RS08960	COG0686	Belongs to the AlaDH PNT family
F3K22_RS08970	COG0494	nUDIX hydrolase
F3K22_RS08975	COG0504	CTP synthase activity
F3K22_RS08980	COG3387	PFAM Glycoside hydrolase 15-related
F3K22_RS08995	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS09000	COG0497	DNA recombination
F3K22_RS09005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F3K22_RS09025	COG1120	ATPase activity
F3K22_RS09030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3K22_RS09035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3K22_RS09040	COG0647	UMP catabolic process
F3K22_RS09075	COG2094	Belongs to the DNA glycosylase MPG family
F3K22_RS09100	COG1881	PFAM PEBP family protein
F3K22_RS09120	COG1119	ATPase activity
F3K22_RS09135	COG2197	response regulator
F3K22_RS09140	COG4585	Histidine kinase
F3K22_RS09145	COG4221	oxidoreductase activity
F3K22_RS09150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F3K22_RS09160	COG0842	Transport permease protein
F3K22_RS09160	COG1131	(ABC) transporter
F3K22_RS09160	COG1716	ATPase activity
F3K22_RS09170	COG0560	Phosphoserine phosphatase
F3K22_RS09170	COG3830	Belongs to the UPF0237 family
F3K22_RS09175	COG0588	phosphoglycerate mutase activity
F3K22_RS09190	COG2186	Transcriptional regulator
F3K22_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS09230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F3K22_RS09250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F3K22_RS09255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3K22_RS09290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F3K22_RS09315	COG1966	Carbon starvation protein
F3K22_RS09340	COG3387	PFAM Glycoside hydrolase 15-related
F3K22_RS09390	COG0488	(ABC) transporter
F3K22_RS09410	COG0235	Class ii aldolase
F3K22_RS09425	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F3K22_RS09430	COG1492	cobalamin metabolic process
F3K22_RS09445	COG1797	cobyrinic acid a,c-diamide synthase activity
F3K22_RS09475	COG1126	abc transporter atp-binding protein
F3K22_RS09480	COG0765	amino acid transport
F3K22_RS09490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F3K22_RS09495	COG0456	acetyltransferase
F3K22_RS09500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F3K22_RS09505	COG1917	Cupin 2, conserved barrel domain protein
F3K22_RS09510	COG5285	phytanoyl-CoA dioxygenase
F3K22_RS09520	COG1595	DNA-templated transcription, initiation
F3K22_RS09545	COG1414	Transcriptional regulator
F3K22_RS09555	COG2252	PERMEase
F3K22_RS09560	COG1595	DNA-templated transcription, initiation
F3K22_RS09580	COG4677	pectinesterase activity
F3K22_RS09585	COG4677	pectinesterase activity
F3K22_RS09595	COG2755	lipolytic protein G-D-S-L family
F3K22_RS09605	COG4677	pectinesterase activity
F3K22_RS09630	COG0395	ABC-type sugar transport system, permease component
F3K22_RS09635	COG1175	transmembrane transport
F3K22_RS09645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS09650	COG1802	Transcriptional regulator
F3K22_RS09675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS09680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3K22_RS09685	COG1349	DNA-binding transcription factor activity
F3K22_RS09700	COG0395	ABC-type sugar transport system, permease component
F3K22_RS09705	COG1063	alcohol dehydrogenase
F3K22_RS09725	COG1802	Transcriptional regulator
F3K22_RS09765	COG1295	ribonuclease BN
F3K22_RS09765	COG1959	2 iron, 2 sulfur cluster binding
F3K22_RS09780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS09790	COG1595	DNA-templated transcription, initiation
F3K22_RS09805	COG2171	N-acyltransferase activity
F3K22_RS09810	COG3226	Transcriptional regulator
F3K22_RS09815	COG2076	Multidrug Resistance protein
F3K22_RS09825	COG2151	metal-sulfur cluster biosynthetic enzyme
F3K22_RS09830	COG0822	iron-sulfur transferase activity
F3K22_RS09835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3K22_RS09840	COG0396	ATPase activity
F3K22_RS09850	COG0719	Fe-S assembly protein
F3K22_RS09865	COG2746	aminoglycoside 3-N-acetyltransferase activity
F3K22_RS09870	COG1131	(ABC) transporter
F3K22_RS09880	COG1612	heme a metabolic process
F3K22_RS09900	COG0109	protoheme IX farnesyltransferase activity
F3K22_RS09905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F3K22_RS09910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F3K22_RS09925	COG0363	glucosamine-6-phosphate deaminase activity
F3K22_RS09940	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS09945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3K22_RS09955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3K22_RS09980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F3K22_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS09990	COG0166	Belongs to the GPI family
F3K22_RS10000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F3K22_RS10005	COG0149	triose-phosphate isomerase activity
F3K22_RS10010	COG0126	phosphoglycerate kinase activity
F3K22_RS10015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F3K22_RS10025	COG1481	regulation of sporulation
F3K22_RS10030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F3K22_RS10035	COG1660	Displays ATPase and GTPase activities
F3K22_RS10040	COG0322	excinuclease ABC activity
F3K22_RS10045	COG2197	response regulator
F3K22_RS10050	COG4585	Histidine kinase
F3K22_RS10065	COG2201	protein-glutamate methylesterase activity
F3K22_RS10085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F3K22_RS10100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3K22_RS10105	COG0765	amino acid transport
F3K22_RS10115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F3K22_RS10120	COG1619	proteins homologs of microcin C7 resistance protein MccF
F3K22_RS10125	COG0477	Major facilitator Superfamily
F3K22_RS10130	COG0387	Pfam Sodium calcium exchanger
F3K22_RS10150	COG0556	nucleotide-excision repair
F3K22_RS10160	COG0584	glycerophosphoryl diester phosphodiesterase
F3K22_RS10165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3K22_RS10175	COG2313	pseudouridylate synthase activity
F3K22_RS10180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3K22_RS10185	COG2226	methyltransferase
F3K22_RS10190	COG0598	Magnesium transport protein CorA
F3K22_RS10220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3K22_RS10225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3K22_RS10255	COG1132	(ABC) transporter
F3K22_RS10280	COG1953	Uracil, thiamine, allantoin
F3K22_RS10285	COG1802	Transcriptional regulator
F3K22_RS10290	COG2267	carboxylic ester hydrolase activity
F3K22_RS10310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F3K22_RS10330	COG0237	dephospho-CoA kinase activity
F3K22_RS10340	COG0539	negative regulation of cytoplasmic translation
F3K22_RS10345	COG2226	methyltransferase
F3K22_RS10350	COG1643	Atp-dependent helicase
F3K22_RS10385	COG2050	protein possibly involved in aromatic compounds catabolism
F3K22_RS10415	COG0411	ABC transporter
F3K22_RS10450	COG0737	Belongs to the 5'-nucleotidase family
F3K22_RS10470	COG4566	intracellular signal transduction
F3K22_RS10475	COG0287	Prephenate dehydrogenase
F3K22_RS10475	COG1605	Chorismate mutase
F3K22_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS10495	COG1024	Enoyl-CoA hydratase
F3K22_RS10515	COG0183	Belongs to the thiolase family
F3K22_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS10530	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS10535	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS10540	COG2304	oxidoreductase activity
F3K22_RS10555	COG0069	glutamate synthase activity
F3K22_RS10555	COG0067	glutamate synthase
F3K22_RS10555	COG0070	glutamate synthase
F3K22_RS10585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3K22_RS10590	COG2301	Belongs to the HpcH HpaI aldolase family
F3K22_RS10595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F3K22_RS10605	COG0159	tryptophan synthase activity
F3K22_RS10610	COG0133	tryptophan synthase activity
F3K22_RS10615	COG0134	indole-3-glycerol-phosphate synthase activity
F3K22_RS10635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F3K22_RS10640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F3K22_RS10650	COG0107	imidazoleglycerol-phosphate synthase activity
F3K22_RS10655	COG0251	oxidation-reduction process
F3K22_RS10660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F3K22_RS10665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F3K22_RS10675	COG0131	Imidazoleglycerol-phosphate dehydratase
F3K22_RS10680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3K22_RS10685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F3K22_RS10705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F3K22_RS10725	COG1432	Conserved Protein
F3K22_RS10735	COG0587	DNA-directed DNA polymerase activity
F3K22_RS10795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F3K22_RS10805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F3K22_RS10810	COG3599	regulation of cell shape
F3K22_RS10820	COG1799	cell septum assembly
F3K22_RS10825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F3K22_RS10830	COG1496	oxidoreductase activity
F3K22_RS10835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F3K22_RS10840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F3K22_RS10845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F3K22_RS10855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F3K22_RS10860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3K22_RS10870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3K22_RS10885	COG0275	rRNA processing
F3K22_RS10895	COG0714	Associated with various cellular activities
F3K22_RS10915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F3K22_RS10925	COG1129	ABC transporter
F3K22_RS10935	COG1309	transcriptional regulator
F3K22_RS10955	COG0352	thiamine-phosphate diphosphorylase activity
F3K22_RS10975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3K22_RS10975	COG2022	thiamine diphosphate biosynthetic process
F3K22_RS10985	COG2022	thiamine diphosphate biosynthetic process
F3K22_RS10990	COG2815	serine threonine protein kinase
F3K22_RS10990	COG0515	serine threonine protein kinase
F3K22_RS10995	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F3K22_RS11000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F3K22_RS11005	COG2193	ferroxidase activity
F3K22_RS11010	COG0243	molybdopterin cofactor binding
F3K22_RS11015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F3K22_RS11035	COG0205	6-phosphofructokinase activity
F3K22_RS11040	COG2197	response regulator
F3K22_RS11045	COG4585	Histidine kinase
F3K22_RS11070	COG1940	carbohydrate kinase activity
F3K22_RS11080	COG0003	Pfam Anion-transporting ATPase
F3K22_RS11150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3K22_RS11155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F3K22_RS11160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F3K22_RS11165	COG0723	plastoquinol--plastocyanin reductase activity
F3K22_RS11175	COG1845	cytochrome c oxidase, subunit III
F3K22_RS11185	COG1376	ErfK ybiS ycfS ynhG family protein
F3K22_RS11195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F3K22_RS11200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F3K22_RS11210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3K22_RS11230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F3K22_RS11235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F3K22_RS11240	COG2197	response regulator
F3K22_RS11245	COG4585	Histidine kinase
F3K22_RS11285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F3K22_RS11310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F3K22_RS11315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3K22_RS11320	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3K22_RS11330	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F3K22_RS11355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3K22_RS11380	COG0321	lipoyl(octanoyl) transferase activity
F3K22_RS11385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F3K22_RS11405	COG0174	glutamine synthetase
F3K22_RS11455	COG0745	RESPONSE REGULATOR receiver
F3K22_RS11480	COG1309	transcriptional regulator
F3K22_RS11540	COG0366	Alpha amylase catalytic
F3K22_RS11545	COG3833	ABC-type maltose transport systems, permease component
F3K22_RS11550	COG1175	transmembrane transport
F3K22_RS11560	COG1609	Transcriptional regulator
F3K22_RS11570	COG0583	DNA-binding transcription factor activity
F3K22_RS11580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F3K22_RS11600	COG0174	glutamine synthetase
F3K22_RS11615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F3K22_RS11615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F3K22_RS11625	COG2814	Major facilitator Superfamily
F3K22_RS11640	COG0477	Major facilitator Superfamily
F3K22_RS11645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F3K22_RS11665	COG1994	Peptidase M50
F3K22_RS11710	COG2837	iron assimilation
F3K22_RS11715	COG0672	)-iron permease
F3K22_RS11750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3K22_RS11755	COG2814	Major facilitator Superfamily
F3K22_RS11765	COG3540	Alkaline phosphatase
F3K22_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS11785	COG2259	Doxx family
F3K22_RS11800	COG2409	Drug exporters of the RND superfamily
F3K22_RS11805	COG4585	Histidine kinase
F3K22_RS11810	COG2197	response regulator
F3K22_RS11815	COG3940	Belongs to the glycosyl hydrolase 43 family
F3K22_RS11820	COG3940	Belongs to the glycosyl hydrolase 43 family
F3K22_RS11845	COG1401	restriction endodeoxyribonuclease activity
F3K22_RS11985	COG3022	response to hydroperoxide
F3K22_RS11990	COG0800	Aldolase
F3K22_RS12005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F3K22_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS12030	COG2030	dehydratase
F3K22_RS12035	COG4585	Histidine kinase
F3K22_RS12040	COG2197	response regulator
F3K22_RS12055	COG0477	Major facilitator Superfamily
F3K22_RS12080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS12105	COG1309	transcriptional regulator
F3K22_RS12140	COG1404	Belongs to the peptidase S8 family
F3K22_RS12155	COG2319	Wd-40 repeat
F3K22_RS12155	COG4249	Peptidase C14 caspase catalytic subunit p20
F3K22_RS12160	COG0183	Belongs to the thiolase family
F3K22_RS12165	COG2124	cytochrome p450
F3K22_RS12180	COG4122	O-methyltransferase activity
F3K22_RS12225	COG1733	regulation of RNA biosynthetic process
F3K22_RS12235	COG3547	Transposase (IS116 IS110 IS902 family)
F3K22_RS12280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F3K22_RS12325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3K22_RS12335	COG0586	Pfam SNARE associated Golgi protein
F3K22_RS12345	COG1358	cellular component organization or biogenesis
F3K22_RS12390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F3K22_RS12395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3K22_RS12405	COG0477	Major facilitator Superfamily
F3K22_RS12410	COG1309	transcriptional regulator
F3K22_RS12425	COG0667	Aldo Keto reductase
F3K22_RS12430	COG0789	Transcriptional regulator
F3K22_RS12450	COG1741	Belongs to the pirin family
F3K22_RS12465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3K22_RS12470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3K22_RS12475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3K22_RS12495	COG1309	transcriptional regulator
F3K22_RS12530	COG2130	NADP-dependent
F3K22_RS12545	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS12550	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS12560	COG1879	ABC-type sugar transport system periplasmic component
F3K22_RS12565	COG1609	Transcriptional regulator
F3K22_RS12575	COG4948	Mandelate Racemase Muconate Lactonizing
F3K22_RS12590	COG4213	ABC transporter substrate-binding protein
F3K22_RS12595	COG1129	ABC transporter
F3K22_RS12600	COG4214	carbohydrate transport
F3K22_RS12610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3K22_RS12660	COG3386	PFAM SMP-30 Gluconolaconase
F3K22_RS12665	COG1414	Transcriptional regulator
F3K22_RS12695	COG4981	capsule polysaccharide biosynthetic process
F3K22_RS12715	COG2835	tetraacyldisaccharide 4'-kinase activity
F3K22_RS12770	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS12775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F3K22_RS12775	COG0825	malonyl-CoA metabolic process
F3K22_RS12780	COG1077	Cell shape determining protein MreB Mrl
F3K22_RS12815	COG3629	intracellular signal transduction
F3K22_RS12815	COG3903	Transcriptional regulator
F3K22_RS12825	COG1053	succinate dehydrogenase
F3K22_RS12845	COG1309	transcriptional regulator
F3K22_RS12850	COG2409	Drug exporters of the RND superfamily
F3K22_RS12875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3K22_RS12885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS12900	COG0477	Major facilitator Superfamily
F3K22_RS12905	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F3K22_RS12930	COG4585	Histidine kinase
F3K22_RS12935	COG2197	response regulator
F3K22_RS12950	COG0546	phosphoglycolate phosphatase activity
F3K22_RS12955	COG2409	Drug exporters of the RND superfamily
F3K22_RS12965	COG0674	pyruvate-flavodoxin oxidoreductase activity
F3K22_RS12965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F3K22_RS12970	COG1013	pyruvate-flavodoxin oxidoreductase activity
F3K22_RS13020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3K22_RS13025	COG3321	synthase
F3K22_RS13025	COG0604	alcohol dehydrogenase
F3K22_RS13045	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS13075	COG1113	amino acid transport
F3K22_RS13085	COG0531	amino acid
F3K22_RS13115	COG2826	transposase and inactivated derivatives, IS30 family
F3K22_RS13120	COG0477	Major facilitator Superfamily
F3K22_RS13145	COG3852	Histidine kinase
F3K22_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS13185	COG1070	Carbohydrate kinase
F3K22_RS13200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F3K22_RS13205	COG0358	DNA primase activity
F3K22_RS13220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F3K22_RS13230	COG2949	membrane
F3K22_RS13240	COG0243	molybdopterin cofactor binding
F3K22_RS13255	COG0701	Predicted permease
F3K22_RS13290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3K22_RS13295	COG2146	nitrite reductase [NAD(P)H] activity
F3K22_RS13295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3K22_RS13305	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS13310	COG0659	secondary active sulfate transmembrane transporter activity
F3K22_RS13320	COG0745	RESPONSE REGULATOR receiver
F3K22_RS13325	COG0642	Histidine kinase
F3K22_RS13335	COG1819	glycosyl
F3K22_RS13355	COG1136	(ABC) transporter
F3K22_RS13360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3K22_RS13360	COG0574	Belongs to the PEP-utilizing enzyme family
F3K22_RS13365	COG1846	Transcriptional regulator
F3K22_RS13365	COG1940	carbohydrate kinase activity
F3K22_RS13370	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
F3K22_RS13395	COG0477	Major facilitator Superfamily
F3K22_RS13425	COG0423	glycine-tRNA ligase activity
F3K22_RS13435	COG1121	(ABC) transporter
F3K22_RS13440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F3K22_RS13455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3K22_RS13460	COG1381	Involved in DNA repair and RecF pathway recombination
F3K22_RS13470	COG3903	Transcriptional regulator
F3K22_RS13470	COG3629	intracellular signal transduction
F3K22_RS13485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS13495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3K22_RS13530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F3K22_RS13555	COG2315	Protein conserved in bacteria
F3K22_RS13565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F3K22_RS13575	COG1414	Transcriptional regulator
F3K22_RS13580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS13585	COG4948	Mandelate Racemase Muconate Lactonizing
F3K22_RS13595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3K22_RS13600	COG1234	tRNA 3'-trailer cleavage
F3K22_RS13605	COG0537	adenosine 5'-monophosphoramidase activity
F3K22_RS13610	COG0793	Belongs to the peptidase S41A family
F3K22_RS13610	COG4946	Tricorn protease homolog
F3K22_RS13635	COG0484	heat shock protein binding
F3K22_RS13640	COG1420	regulation of RNA biosynthetic process
F3K22_RS13685	COG0481	GTPase activity
F3K22_RS13690	COG0268	Binds directly to 16S ribosomal RNA
F3K22_RS13715	COG1555	photosystem II stabilization
F3K22_RS13720	COG1307	EDD domain protein, DegV family
F3K22_RS13730	COG0495	leucyl-tRNA aminoacylation
F3K22_RS13740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F3K22_RS13765	COG0588	phosphoglycerate mutase activity
F3K22_RS13770	COG0799	negative regulation of ribosome biogenesis
F3K22_RS13780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F3K22_RS13795	COG0501	Belongs to the peptidase M48B family
F3K22_RS13810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F3K22_RS13820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F3K22_RS13830	COG2826	transposase and inactivated derivatives, IS30 family
F3K22_RS13835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F3K22_RS13840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F3K22_RS13845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F3K22_RS13850	COG1530	ribonuclease E activity
F3K22_RS13865	COG0457	Tetratricopeptide repeat
F3K22_RS13865	COG0463	Glycosyl transferase, family 2
F3K22_RS13880	COG0539	negative regulation of cytoplasmic translation
F3K22_RS13880	COG1185	polyribonucleotide nucleotidyltransferase activity
F3K22_RS13880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F3K22_RS13900	COG0772	Belongs to the SEDS family
F3K22_RS13905	COG0768	penicillin binding
F3K22_RS13920	COG1077	Cell shape determining protein MreB Mrl
F3K22_RS13925	COG0105	UTP biosynthetic process
F3K22_RS13935	COG0285	dihydrofolate synthase activity
F3K22_RS13940	COG0525	valine-tRNA ligase activity
F3K22_RS13955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F3K22_RS13960	COG0740	serine-type endopeptidase activity
F3K22_RS13965	COG0740	serine-type endopeptidase activity
F3K22_RS13970	COG0544	peptidyl-prolyl cis-trans isomerase activity
F3K22_RS13990	COG3594	Acyltransferase
F3K22_RS14005	COG4552	Acetyltransferase involved in intracellular survival and related
F3K22_RS14020	COG1113	amino acid transport
F3K22_RS14025	COG0515	serine threonine protein kinase
F3K22_RS14050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3K22_RS14055	COG1116	anion transmembrane transporter activity
F3K22_RS14060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS14070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F3K22_RS14080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F3K22_RS14135	COG0697	spore germination
F3K22_RS14140	COG1846	Transcriptional regulator
F3K22_RS14180	COG1131	(ABC) transporter
F3K22_RS14185	COG0668	transmembrane transport
F3K22_RS14210	COG1175	transmembrane transport
F3K22_RS14215	COG0395	ABC-type sugar transport system, permease component
F3K22_RS14220	COG1486	melibiose metabolic process
F3K22_RS14235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3K22_RS14265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F3K22_RS14295	COG0629	single-stranded DNA binding
F3K22_RS14320	COG2304	oxidoreductase activity
F3K22_RS14365	COG0297	glycogen (starch) synthase activity
F3K22_RS14370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F3K22_RS14380	COG0728	peptidoglycan biosynthetic process
F3K22_RS14415	COG0492	ferredoxin-NADP+ reductase activity
F3K22_RS14475	COG3962	Belongs to the TPP enzyme family
F3K22_RS14480	COG3718	enzyme involved in inositol metabolism
F3K22_RS14490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3K22_RS14515	COG2409	Drug exporters of the RND superfamily
F3K22_RS14540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F3K22_RS14570	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F3K22_RS14580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3K22_RS14585	COG1869	D-ribose catabolic process
F3K22_RS14615	COG1674	ftsk spoiiie
F3K22_RS14640	COG3903	Transcriptional regulator
F3K22_RS14640	COG3629	intracellular signal transduction
F3K22_RS14720	COG0673	inositol 2-dehydrogenase activity
F3K22_RS14745	COG2890	protein-(glutamine-N5) methyltransferase activity
F3K22_RS14755	COG0723	plastoquinol--plastocyanin reductase activity
F3K22_RS14755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3K22_RS14770	COG1472	Belongs to the glycosyl hydrolase 3 family
F3K22_RS14810	COG2356	endonuclease I
F3K22_RS14835	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F3K22_RS14865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F3K22_RS14880	COG0028	Belongs to the TPP enzyme family
F3K22_RS14900	COG1946	Acyl-CoA thioesterase
F3K22_RS14910	COG1309	transcriptional regulator
F3K22_RS14915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3K22_RS14930	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS14955	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F3K22_RS14995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3K22_RS15000	COG0589	response to stress
F3K22_RS15010	COG4977	sequence-specific DNA binding
F3K22_RS15015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F3K22_RS15040	COG1725	Transcriptional regulator
F3K22_RS15065	COG0395	ABC-type sugar transport system, permease component
F3K22_RS15090	COG0395	ABC-type sugar transport system, permease component
F3K22_RS15100	COG1653	transport
F3K22_RS15110	COG0745	RESPONSE REGULATOR receiver
F3K22_RS15120	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F3K22_RS15135	COG0588	phosphoglycerate mutase activity
F3K22_RS15185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS15195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3K22_RS15200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3K22_RS15205	COG0765	amino acid transport
F3K22_RS15210	COG0765	amino acid transport
F3K22_RS15215	COG1126	abc transporter atp-binding protein
F3K22_RS15230	COG2197	response regulator
F3K22_RS15240	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS15250	COG3397	chitin binding
F3K22_RS15330	COG0673	inositol 2-dehydrogenase activity
F3K22_RS15335	COG4702	Belongs to the UPF0303 family
F3K22_RS15340	COG0706	membrane insertase activity
F3K22_RS15350	COG3764	Sortase (surface protein transpeptidase)
F3K22_RS15495	COG2271	Major facilitator Superfamily
F3K22_RS15500	COG2733	membrane
F3K22_RS15530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3K22_RS15560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F3K22_RS15570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F3K22_RS15575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F3K22_RS15585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F3K22_RS15625	COG2124	cytochrome p450
F3K22_RS15640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F3K22_RS15645	COG1263	PTS System
F3K22_RS15680	COG1113	amino acid transport
F3K22_RS15690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F3K22_RS15705	COG1335	isochorismatase
F3K22_RS15740	COG0277	FAD linked oxidase domain protein
F3K22_RS15750	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F3K22_RS15785	COG3654	unkown
F3K22_RS15810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3K22_RS15825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F3K22_RS15830	COG0395	ABC-type sugar transport system, permease component
F3K22_RS15835	COG1175	transmembrane transport
F3K22_RS15840	COG1653	transport
F3K22_RS15850	COG1678	Uncharacterized ACR, COG1678
F3K22_RS15855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3K22_RS15860	COG0776	regulation of translation
F3K22_RS15870	COG3973	AAA domain
F3K22_RS15895	COG2223	nitrite transmembrane transporter activity
F3K22_RS15930	COG1501	Belongs to the glycosyl hydrolase 31 family
F3K22_RS15945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F3K22_RS15950	COG0793	Belongs to the peptidase S41A family
F3K22_RS15960	COG2884	Cell division ATP-binding protein ftsE
F3K22_RS15975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F3K22_RS15980	COG0515	serine threonine protein kinase
F3K22_RS15985	COG0515	serine threonine protein kinase
F3K22_RS15995	COG1653	transport
F3K22_RS16000	COG1175	transmembrane transport
F3K22_RS16005	COG0395	ABC-type sugar transport system, permease component
F3K22_RS16010	COG0463	Glycosyl transferase, family 2
F3K22_RS16010	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F3K22_RS16015	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F3K22_RS16020	COG1216	Glycosyl transferase, family 2
F3K22_RS16030	COG1764	response to oxidative stress
F3K22_RS16035	COG1846	Transcriptional regulator
F3K22_RS16040	COG1215	transferase activity, transferring glycosyl groups
F3K22_RS16080	COG1134	teichoic acid transport
F3K22_RS16085	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS16090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F3K22_RS16105	COG2902	Dehydrogenase
F3K22_RS16130	COG0653	protein targeting
F3K22_RS16140	COG3214	Protein conserved in bacteria
F3K22_RS16145	COG2197	response regulator
F3K22_RS16150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F3K22_RS16160	COG0823	Involved in the tonB-independent uptake of proteins
F3K22_RS16165	COG5002	protein histidine kinase activity
F3K22_RS16165	COG5000	phosphorelay sensor kinase activity
F3K22_RS16170	COG0745	RESPONSE REGULATOR receiver
F3K22_RS16175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F3K22_RS16195	COG0714	Associated with various cellular activities
F3K22_RS16235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F3K22_RS16255	COG2835	tetraacyldisaccharide 4'-kinase activity
F3K22_RS16295	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F3K22_RS16300	COG0778	Nitroreductase
F3K22_RS16300	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F3K22_RS16330	COG1316	TRANSCRIPTIONal
F3K22_RS16345	COG1316	TRANSCRIPTIONal
F3K22_RS16350	COG1316	TRANSCRIPTIONal
F3K22_RS16365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F3K22_RS16390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F3K22_RS16405	COG2205	protein histidine kinase activity
F3K22_RS16410	COG0745	RESPONSE REGULATOR receiver
F3K22_RS16415	COG3104	oligopeptide transport
F3K22_RS16435	COG1366	Belongs to the anti-sigma-factor antagonist family
F3K22_RS16440	COG1191	sigma factor activity
F3K22_RS16450	COG1228	amidohydrolase
F3K22_RS16460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3K22_RS16465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F3K22_RS16510	COG2986	histidine ammonia-lyase
F3K22_RS16525	COG2755	lipolytic protein G-D-S-L family
F3K22_RS16530	COG0183	Belongs to the thiolase family
F3K22_RS16560	COG1136	(ABC) transporter
F3K22_RS16565	COG0577	efflux transmembrane transporter activity
F3K22_RS16570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3K22_RS16575	COG1252	NADH dehydrogenase
F3K22_RS16595	COG0148	phosphopyruvate hydratase activity
F3K22_RS16660	COG0577	efflux transmembrane transporter activity
F3K22_RS16665	COG1136	(ABC) transporter
F3K22_RS16670	COG0477	Major facilitator Superfamily
F3K22_RS16680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3K22_RS16710	COG4585	Histidine kinase
F3K22_RS16720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F3K22_RS16725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F3K22_RS16730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F3K22_RS16735	COG0193	aminoacyl-tRNA hydrolase activity
F3K22_RS16745	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F3K22_RS16755	COG1309	transcriptional regulator
F3K22_RS16760	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS16770	COG0477	Major facilitator Superfamily
F3K22_RS16775	COG4106	trans-aconitate 2-methyltransferase activity
F3K22_RS16785	COG2197	response regulator
F3K22_RS16795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F3K22_RS16810	COG1404	Belongs to the peptidase S8 family
F3K22_RS16820	COG1131	(ABC) transporter
F3K22_RS16825	COG1725	Transcriptional regulator
F3K22_RS16850	COG0488	(ABC) transporter
F3K22_RS16860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F3K22_RS16865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F3K22_RS16875	COG0084	hydrolase, TatD family'
F3K22_RS16895	COG0768	penicillin binding
F3K22_RS16910	COG0442	prolyl-tRNA aminoacylation
F3K22_RS16930	COG1764	response to oxidative stress
F3K22_RS16935	COG1846	Transcriptional regulator
F3K22_RS16940	COG1122	ATPase activity
F3K22_RS16950	COG0310	cobalt ion transport
F3K22_RS16975	COG2318	DinB family
F3K22_RS16980	COG2409	Drug exporters of the RND superfamily
F3K22_RS16990	COG4946	Tricorn protease homolog
F3K22_RS16990	COG0793	Belongs to the peptidase S41A family
F3K22_RS17010	COG2072	flavoprotein involved in K transport
F3K22_RS17025	COG0708	Exodeoxyribonuclease III
F3K22_RS17050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3K22_RS17055	COG0315	cyclic pyranopterin monophosphate synthase activity
F3K22_RS17055	COG0521	Mo-molybdopterin cofactor biosynthetic process
F3K22_RS17060	COG0315	cyclic pyranopterin monophosphate synthase activity
F3K22_RS17070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F3K22_RS17075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F3K22_RS17085	COG3263	regulation of cellular component size
F3K22_RS17100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F3K22_RS17110	COG1970	mechanosensitive ion channel activity
F3K22_RS17130	COG1376	ErfK ybiS ycfS ynhG family protein
F3K22_RS17145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F3K22_RS17145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F3K22_RS17155	COG1349	DNA-binding transcription factor activity
F3K22_RS17160	COG0477	Major facilitator Superfamily
F3K22_RS17175	COG1247	-acetyltransferase
F3K22_RS17185	COG3384	dioxygenase
F3K22_RS17190	COG1846	Transcriptional regulator
F3K22_RS17210	COG1414	Transcriptional regulator
F3K22_RS17230	COG4555	ABC transporter
F3K22_RS17245	COG4974	Belongs to the 'phage' integrase family
F3K22_RS17330	COG2249	NAD(P)H dehydrogenase (quinone) activity
F3K22_RS17415	COG0386	Belongs to the glutathione peroxidase family
F3K22_RS17430	COG1686	Belongs to the peptidase S11 family
F3K22_RS17465	COG3896	Chloramphenicol phosphotransferase-like protein
F3K22_RS17490	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F3K22_RS17500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3K22_RS17530	COG2226	methyltransferase
F3K22_RS17535	COG4257	antibiotic catabolic process
F3K22_RS17550	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS17555	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F3K22_RS17580	COG2197	response regulator
F3K22_RS17605	COG3629	intracellular signal transduction
F3K22_RS17605	COG3903	Transcriptional regulator
F3K22_RS17635	COG1024	Enoyl-CoA hydratase
F3K22_RS17665	COG1309	transcriptional regulator
F3K22_RS17675	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS17685	COG0259	pyridoxamine-phosphate oxidase activity
F3K22_RS17725	COG2072	flavoprotein involved in K transport
F3K22_RS17735	COG1024	Enoyl-CoA hydratase
F3K22_RS17755	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS17760	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS17775	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS17780	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS17790	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS17800	COG1366	Belongs to the anti-sigma-factor antagonist family
F3K22_RS17845	COG2826	transposase and inactivated derivatives, IS30 family
F3K22_RS17850	COG0596	Alpha beta hydrolase
F3K22_RS17850	COG2945	thiolester hydrolase activity
F3K22_RS17860	COG4821	SIS domain
F3K22_RS17885	COG0259	pyridoxamine-phosphate oxidase activity
F3K22_RS17895	COG1024	Enoyl-CoA hydratase
F3K22_RS17900	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS17915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3K22_RS17970	COG0277	FAD linked oxidase domain protein
F3K22_RS17970	COG0247	lactate metabolic process
F3K22_RS17995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F3K22_RS18005	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F3K22_RS18040	COG0667	Aldo Keto reductase
F3K22_RS18075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F3K22_RS18110	COG2814	Major facilitator Superfamily
F3K22_RS18120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F3K22_RS18125	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F3K22_RS18130	COG1278	Cold shock
F3K22_RS18165	COG3467	pyridoxamine 5'-phosphate
F3K22_RS18170	COG1061	Type III restriction enzyme res subunit
F3K22_RS18180	COG3973	AAA domain
F3K22_RS18235	COG1737	Transcriptional regulator
F3K22_RS18240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F3K22_RS18270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3K22_RS18320	COG0459	protein refolding
F3K22_RS18325	COG1278	Cold shock
F3K22_RS18340	COG0463	Glycosyl transferase, family 2
F3K22_RS18360	COG2182	Extracellular solute-binding protein
F3K22_RS18370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F3K22_RS18400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F3K22_RS18440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3K22_RS18460	COG3842	ATPase activity
F3K22_RS18485	COG0215	cysteine-tRNA ligase activity
F3K22_RS18490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F3K22_RS18495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F3K22_RS18500	COG1329	Transcriptional regulator
F3K22_RS18515	COG5002	protein histidine kinase activity
F3K22_RS18565	COG0588	phosphoglycerate mutase activity
F3K22_RS18590	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS18600	COG0791	NLP P60 protein
F3K22_RS18630	COG2318	DinB family
F3K22_RS18645	COG1309	transcriptional regulator
F3K22_RS18660	COG2188	Transcriptional regulator
F3K22_RS18670	COG2188	Transcriptional regulator
F3K22_RS18675	COG4552	Acetyltransferase involved in intracellular survival and related
F3K22_RS18685	COG1490	D-aminoacyl-tRNA deacylase activity
F3K22_RS18695	COG0735	belongs to the Fur family
F3K22_RS18700	COG3485	protocatechuate 3,4-dioxygenase
F3K22_RS18720	COG2897	thiosulfate sulfurtransferase activity
F3K22_RS18745	COG0745	RESPONSE REGULATOR receiver
F3K22_RS18750	COG1609	Transcriptional regulator
F3K22_RS18755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3K22_RS18765	COG0745	RESPONSE REGULATOR receiver
F3K22_RS18780	COG0737	Belongs to the 5'-nucleotidase family
F3K22_RS18785	COG0456	acetyltransferase
F3K22_RS18790	COG1725	Transcriptional regulator
F3K22_RS18795	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F3K22_RS18810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F3K22_RS18820	COG0494	nUDIX hydrolase
F3K22_RS18820	COG0406	alpha-ribazole phosphatase activity
F3K22_RS18835	COG1937	Protein conserved in bacteria
F3K22_RS18845	COG0306	phosphate transporter
F3K22_RS18850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F3K22_RS18870	COG0277	FAD linked oxidase domain protein
F3K22_RS18875	COG0671	phosphoesterase, PA-phosphatase related
F3K22_RS18880	COG0739	heme binding
F3K22_RS18880	COG0741	lytic transglycosylase activity
F3K22_RS18880	COG1196	nuclear chromosome segregation
F3K22_RS18960	COG1252	NADH dehydrogenase
F3K22_RS18985	COG0579	oxidoreductase
F3K22_RS18990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F3K22_RS19015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3K22_RS19025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3K22_RS19025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3K22_RS19045	COG1136	(ABC) transporter
F3K22_RS19070	COG3328	transposase activity
F3K22_RS19075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3K22_RS19080	COG0297	glycogen (starch) synthase activity
F3K22_RS19100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3K22_RS19165	COG0513	Belongs to the DEAD box helicase family
F3K22_RS19205	COG1643	Atp-dependent helicase
F3K22_RS19240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F3K22_RS19265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F3K22_RS19270	COG0047	phosphoribosylformylglycinamidine synthase activity
F3K22_RS19275	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F3K22_RS19310	COG2197	response regulator
F3K22_RS19320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F3K22_RS19335	COG0151	Belongs to the GarS family
F3K22_RS19375	COG0515	serine threonine protein kinase
F3K22_RS19410	COG1454	alcohol dehydrogenase
F3K22_RS19415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3K22_RS19475	COG1276	copper resistance
F3K22_RS19475	COG2372	response to copper ion
F3K22_RS19525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F3K22_RS19560	COG1191	sigma factor activity
F3K22_RS19565	COG1191	sigma factor activity
F3K22_RS19580	COG0477	Major facilitator Superfamily
F3K22_RS19585	COG2353	YceI-like domain
F3K22_RS19590	COG3467	pyridoxamine 5'-phosphate
F3K22_RS19600	COG0477	Major facilitator Superfamily
F3K22_RS19605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F3K22_RS19615	COG2205	protein histidine kinase activity
F3K22_RS19620	COG0745	RESPONSE REGULATOR receiver
F3K22_RS19625	COG2329	Antibiotic biosynthesis monooxygenase
F3K22_RS19640	COG0739	heme binding
F3K22_RS19660	COG0784	Response regulator, receiver
F3K22_RS19665	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS19670	COG1595	DNA-templated transcription, initiation
F3K22_RS19705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F3K22_RS19835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3K22_RS19850	COG0653	protein targeting
F3K22_RS19870	COG0006	proline dipeptidase activity
F3K22_RS19875	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F3K22_RS19890	COG0641	radical SAM
F3K22_RS19920	COG1999	signal sequence binding
F3K22_RS19935	COG2837	iron assimilation
F3K22_RS19945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F3K22_RS19950	COG0561	phosphatase activity
F3K22_RS19980	COG1131	(ABC) transporter
F3K22_RS19995	COG0789	Transcriptional regulator
F3K22_RS20000	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F3K22_RS20010	COG0561	phosphatase activity
F3K22_RS20015	COG0739	heme binding
F3K22_RS20015	COG0741	lytic transglycosylase activity
F3K22_RS20015	COG1196	nuclear chromosome segregation
F3K22_RS20020	COG4988	ABC transporter
F3K22_RS20025	COG1294	oxidase, subunit
F3K22_RS20030	COG1271	oxidase subunit
F3K22_RS20035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3K22_RS20040	COG1609	Transcriptional regulator
F3K22_RS20060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F3K22_RS20085	COG0662	Cupin 2, conserved barrel domain protein
F3K22_RS20090	COG1950	PFAM Membrane protein of
F3K22_RS20095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3K22_RS20100	COG0626	cystathionine gamma-synthase activity
F3K22_RS20125	COG2814	Major facilitator Superfamily
F3K22_RS20145	COG0305	Participates in initiation and elongation during chromosome replication
F3K22_RS20155	COG0359	binds to the 23S rRNA
F3K22_RS20160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F3K22_RS20165	COG0629	single-stranded DNA binding
F3K22_RS20170	COG0360	Binds together with S18 to 16S ribosomal RNA
F3K22_RS20195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3K22_RS20205	COG1260	myo-inositol-1-phosphate synthase
F3K22_RS20215	COG0617	tRNA 3'-terminal CCA addition
F3K22_RS20230	COG0515	serine threonine protein kinase
F3K22_RS20230	COG2815	serine threonine protein kinase
F3K22_RS20235	COG1595	DNA-templated transcription, initiation
F3K22_RS20245	COG0492	ferredoxin-NADP+ reductase activity
F3K22_RS20250	COG3118	belongs to the thioredoxin family
F3K22_RS20265	COG1192	Involved in chromosome partitioning
F3K22_RS20270	COG0357	Ribosomal RNA small subunit methyltransferase G
F3K22_RS20280	COG0706	membrane insertase activity
F3K22_RS20285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F3K22_RS20290	COG0594	ribonuclease P activity
F3K22_RS20300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F3K22_RS20305	COG0592	DNA-directed DNA polymerase activity
F3K22_RS20310	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F3K22_RS20315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F3K22_RS20320	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F3K22_RS20325	COG0187	DNA topoisomerase II activity
F3K22_RS20330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3K22_RS20750	COG0515	serine threonine protein kinase
F3K22_RS20775	COG0705	Rhomboid family
F3K22_RS20790	COG3764	Sortase (surface protein transpeptidase)
F3K22_RS20805	COG3764	Sortase (surface protein transpeptidase)
F3K22_RS20810	COG3764	Sortase (surface protein transpeptidase)
F3K22_RS20815	COG0515	serine threonine protein kinase
F3K22_RS20835	COG1716	ATPase activity
F3K22_RS20840	COG1716	ATPase activity
F3K22_RS20855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F3K22_RS20860	COG1733	regulation of RNA biosynthetic process
F3K22_RS20905	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS20910	COG1309	transcriptional regulator
F3K22_RS20915	COG1522	sequence-specific DNA binding
F3K22_RS20935	COG0746	molybdenum cofactor guanylyltransferase activity
F3K22_RS20940	COG0303	'Molybdopterin
F3K22_RS20975	COG0515	serine threonine protein kinase
F3K22_RS20980	COG0515	serine threonine protein kinase
F3K22_RS20990	COG0022	dehydrogenase e1 component
F3K22_RS20995	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3K22_RS21010	COG1802	Transcriptional regulator
F3K22_RS21040	COG1362	aminopeptidase activity
F3K22_RS21045	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS21055	COG1741	Belongs to the pirin family
F3K22_RS21065	COG0628	permease
F3K22_RS21075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F3K22_RS21105	COG2340	Cysteine-rich secretory protein family
F3K22_RS21115	COG3866	Pectate lyase
F3K22_RS21165	COG1289	transmembrane transporter activity
F3K22_RS21180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F3K22_RS21225	COG0745	RESPONSE REGULATOR receiver
F3K22_RS21240	COG1595	DNA-templated transcription, initiation
F3K22_RS21260	COG1595	DNA-templated transcription, initiation
F3K22_RS21290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F3K22_RS21385	COG3345	alpha-galactosidase
F3K22_RS21390	COG1733	regulation of RNA biosynthetic process
F3K22_RS21455	COG0137	argininosuccinate synthase activity
F3K22_RS21565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3K22_RS21575	COG2188	Transcriptional regulator
F3K22_RS21590	COG2409	Drug exporters of the RND superfamily
F3K22_RS21595	COG4585	Histidine kinase
F3K22_RS21600	COG2197	response regulator
F3K22_RS21620	COG4585	Histidine kinase
F3K22_RS21630	COG1609	Transcriptional regulator
F3K22_RS21685	COG3973	AAA domain
F3K22_RS21695	COG3250	beta-galactosidase activity
F3K22_RS21700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F3K22_RS21705	COG2764	glyoxalase bleomycin resistance protein dioxygenase
F3K22_RS21720	COG0513	Belongs to the DEAD box helicase family
F3K22_RS21725	COG1278	Cold shock
F3K22_RS21740	COG0531	amino acid
F3K22_RS21745	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F3K22_RS21760	COG1295	ribonuclease BN
F3K22_RS21785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3K22_RS21800	COG0662	Cupin 2, conserved barrel domain protein
F3K22_RS21820	COG2072	flavoprotein involved in K transport
F3K22_RS21830	COG1309	transcriptional regulator
F3K22_RS21835	COG4214	carbohydrate transport
F3K22_RS21845	COG4213	ABC transporter substrate-binding protein
F3K22_RS21850	COG0726	polysaccharide deacetylase
F3K22_RS21865	COG4213	ABC transporter substrate-binding protein
F3K22_RS21920	COG0725	ABC transporter, periplasmic molybdate-binding protein
F3K22_RS21950	COG2801	Transposase and inactivated derivatives
F3K22_RS21965	COG2255	four-way junction helicase activity
F3K22_RS22000	COG3321	synthase
F3K22_RS22000	COG0604	alcohol dehydrogenase
F3K22_RS22025	COG2188	Transcriptional regulator
F3K22_RS22035	COG1609	Transcriptional regulator
F3K22_RS22115	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS22130	COG3693	PFAM glycoside hydrolase, family 10
F3K22_RS22165	COG0583	DNA-binding transcription factor activity
F3K22_RS22170	COG1309	transcriptional regulator
F3K22_RS22200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3K22_RS22205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3K22_RS22210	COG1116	anion transmembrane transporter activity
F3K22_RS22215	COG0657	acetylesterase activity
F3K22_RS22220	COG1414	Transcriptional regulator
F3K22_RS22380	COG4221	oxidoreductase activity
F3K22_RS22390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F3K22_RS22410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS22440	COG2814	Major facilitator Superfamily
F3K22_RS22505	COG0659	secondary active sulfate transmembrane transporter activity
F3K22_RS22535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F3K22_RS22570	COG2268	Band 7 protein
F3K22_RS22575	COG1585	Membrane protein implicated in regulation of membrane protease activity
F3K22_RS22585	COG1366	Belongs to the anti-sigma-factor antagonist family
F3K22_RS22595	COG2255	four-way junction helicase activity
F3K22_RS22660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F3K22_RS22740	COG0745	RESPONSE REGULATOR receiver
F3K22_RS22745	COG5002	protein histidine kinase activity
F3K22_RS22770	COG0717	Belongs to the dCTP deaminase family
F3K22_RS22830	COG0247	lactate metabolic process
F3K22_RS22830	COG2181	nitrate reductase activity
F3K22_RS22835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3K22_RS22840	COG0443	Heat shock 70 kDa protein
F3K22_RS22845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F3K22_RS22850	COG0484	heat shock protein binding
F3K22_RS22855	COG0789	Transcriptional regulator
F3K22_RS22915	COG4213	ABC transporter substrate-binding protein
F3K22_RS22920	COG1305	Transglutaminase-like
F3K22_RS22960	COG0542	response to heat
F3K22_RS22980	COG0745	RESPONSE REGULATOR receiver
F3K22_RS22990	COG2409	Drug exporters of the RND superfamily
F3K22_RS23010	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F3K22_RS23025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F3K22_RS23030	COG0191	fructose-bisphosphate aldolase activity
F3K22_RS23035	COG0477	Major facilitator Superfamily
F3K22_RS23045	COG3483	tryptophan 2,3-dioxygenase activity
F3K22_RS23050	COG3844	kynureninase activity
F3K22_RS23070	COG4585	Histidine kinase
F3K22_RS23075	COG2197	response regulator
F3K22_RS23080	COG4585	Histidine kinase
F3K22_RS23085	COG2197	response regulator
F3K22_RS23090	COG2124	cytochrome p450
F3K22_RS23100	COG3559	Exporter of polyketide antibiotics
F3K22_RS23105	COG1131	(ABC) transporter
F3K22_RS23165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F3K22_RS23185	COG1802	Transcriptional regulator
F3K22_RS23195	COG0693	protein deglycase activity
F3K22_RS23215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F3K22_RS23220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F3K22_RS23230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F3K22_RS23265	COG3903	Transcriptional regulator
F3K22_RS23265	COG3629	intracellular signal transduction
F3K22_RS23275	COG5002	protein histidine kinase activity
F3K22_RS23300	COG1595	DNA-templated transcription, initiation
F3K22_RS23340	COG0523	cobalamin synthesis protein
F3K22_RS23350	COG0701	Predicted permease
F3K22_RS23375	COG0640	Transcriptional regulator
F3K22_RS23385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3K22_RS23390	COG1247	-acetyltransferase
F3K22_RS23405	COG1408	metallophosphoesterase
F3K22_RS23425	COG0003	Pfam Anion-transporting ATPase
F3K22_RS23440	COG0251	oxidation-reduction process
F3K22_RS23450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3K22_RS23480	COG0596	Alpha beta hydrolase
F3K22_RS23490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F3K22_RS23495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3K22_RS23500	COG0288	reversible hydration of carbon dioxide
F3K22_RS23560	COG1205	dead DEAH box helicase
F3K22_RS23560	COG1111	helicase
F3K22_RS23565	COG1366	Belongs to the anti-sigma-factor antagonist family
F3K22_RS23570	COG2172	sigma factor antagonist activity
F3K22_RS23575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F3K22_RS23600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F3K22_RS23600	COG1754	DNA topoisomerase type I activity
F3K22_RS23605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F3K22_RS23610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F3K22_RS23640	COG0017	Asparaginyl-tRNA synthetase
F3K22_RS23650	COG2226	methyltransferase
F3K22_RS23655	COG1619	proteins homologs of microcin C7 resistance protein MccF
F3K22_RS23705	COG2264	protein methyltransferase activity
F3K22_RS23800	COG0592	DNA-directed DNA polymerase activity
F3K22_RS23820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F3K22_RS23845	COG0515	serine threonine protein kinase
F3K22_RS23860	COG1653	transport
F3K22_RS23870	COG2197	response regulator
F3K22_RS23880	COG1136	(ABC) transporter
F3K22_RS23880	COG0577	efflux transmembrane transporter activity
F3K22_RS23885	COG4585	Histidine kinase
F3K22_RS23890	COG2197	response regulator
F3K22_RS23910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3K22_RS23910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3K22_RS23925	COG1136	(ABC) transporter
F3K22_RS23925	COG0577	efflux transmembrane transporter activity
F3K22_RS23945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F3K22_RS23950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F3K22_RS23955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F3K22_RS23960	COG0254	rRNA binding
F3K22_RS23970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F3K22_RS23990	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS23995	COG2318	DinB family
F3K22_RS24015	COG0076	glutamate decarboxylase activity
F3K22_RS24025	COG0789	Transcriptional regulator
F3K22_RS24030	COG0586	Pfam SNARE associated Golgi protein
F3K22_RS24040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F3K22_RS24055	COG0037	tRNA processing
F3K22_RS24070	COG0302	gtp cyclohydrolase
F3K22_RS24080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F3K22_RS24085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F3K22_RS24125	COG0649	NAD binding
F3K22_RS24155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F3K22_RS24160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F3K22_RS24170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F3K22_RS24190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F3K22_RS24200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F3K22_RS24210	COG0739	heme binding
F3K22_RS24230	COG2205	protein histidine kinase activity
F3K22_RS24235	COG0745	RESPONSE REGULATOR receiver
F3K22_RS24245	COG1595	DNA-templated transcription, initiation
F3K22_RS24250	COG1194	a g-specific adenine glycosylase
F3K22_RS24265	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F3K22_RS24290	COG0248	Ppx GppA phosphatase
F3K22_RS24295	COG1082	Xylose isomerase domain protein TIM barrel
F3K22_RS24300	COG1309	transcriptional regulator
F3K22_RS24305	COG0129	dihydroxy-acid dehydratase activity
F3K22_RS24310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3K22_RS24310	COG0515	serine threonine protein kinase
F3K22_RS24315	COG4991	sh3 domain protein
F3K22_RS24320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F3K22_RS24325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3K22_RS24335	COG4974	Belongs to the 'phage' integrase family
F3K22_RS24355	COG0842	Transport permease protein
F3K22_RS24355	COG1129	ABC transporter
F3K22_RS24365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F3K22_RS24370	COG0180	Tryptophanyl-tRNA synthetase
F3K22_RS24390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3K22_RS24395	COG0738	Major facilitator superfamily
F3K22_RS24450	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F3K22_RS24455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F3K22_RS24460	COG0181	hydroxymethylbilane synthase activity
F3K22_RS24465	COG1648	precorrin-2 dehydrogenase activity
F3K22_RS24465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F3K22_RS24480	COG0113	porphobilinogen synthase activity
F3K22_RS24505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3K22_RS24515	COG0018	arginyl-trna synthetase
F3K22_RS24520	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F3K22_RS24525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F3K22_RS24550	COG1690	Belongs to the RtcB family
F3K22_RS24575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS24585	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS24620	COG0436	Aminotransferase
F3K22_RS24660	COG0242	peptide deformylase activity
F3K22_RS24665	COG0242	peptide deformylase activity
F3K22_RS24670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F3K22_RS24675	COG0406	alpha-ribazole phosphatase activity
F3K22_RS24690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F3K22_RS24700	COG1333	cytochrome c biogenesis protein
F3K22_RS24705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F3K22_RS24740	COG1725	Transcriptional regulator
F3K22_RS24805	COG0789	Transcriptional regulator
F3K22_RS24815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F3K22_RS24835	COG0163	prenyltransferase activity
F3K22_RS24845	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F3K22_RS24860	COG1309	transcriptional regulator
F3K22_RS24900	COG1278	Cold shock
F3K22_RS24905	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F3K22_RS24920	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F3K22_RS24935	COG2226	methyltransferase
F3K22_RS24970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3K22_RS24975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3K22_RS24980	COG0649	NAD binding
F3K22_RS24990	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F3K22_RS24995	COG1034	ATP synthesis coupled electron transport
F3K22_RS25000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F3K22_RS25005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3K22_RS25010	COG0839	Belongs to the complex I subunit 6 family
F3K22_RS25015	COG0713	ATP synthesis coupled electron transport
F3K22_RS25020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F3K22_RS25030	COG1007	ATP synthesis coupled electron transport
F3K22_RS25035	COG0514	ATP-dependent DNA helicase (RecQ)
F3K22_RS25045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F3K22_RS25055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3K22_RS25070	COG2188	Transcriptional regulator
F3K22_RS25085	COG0561	phosphatase activity
F3K22_RS25095	COG0142	geranyltranstransferase activity
F3K22_RS25105	COG1131	(ABC) transporter
F3K22_RS25115	COG0655	NAD(P)H dehydrogenase (quinone) activity
F3K22_RS25165	COG1196	nuclear chromosome segregation
F3K22_RS25165	COG0741	lytic transglycosylase activity
F3K22_RS25165	COG0739	heme binding
F3K22_RS25195	COG0702	epimerase
F3K22_RS25200	COG1733	regulation of RNA biosynthetic process
F3K22_RS25205	COG1013	pyruvate-flavodoxin oxidoreductase activity
F3K22_RS25210	COG0674	pyruvate-flavodoxin oxidoreductase activity
F3K22_RS25210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F3K22_RS25230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3K22_RS25235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3K22_RS25240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3K22_RS25245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F3K22_RS25250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3K22_RS25255	COG0839	Belongs to the complex I subunit 6 family
F3K22_RS25260	COG0713	ATP synthesis coupled electron transport
F3K22_RS25275	COG1007	ATP synthesis coupled electron transport
F3K22_RS25280	COG0501	Belongs to the peptidase M48B family
F3K22_RS25285	COG3304	Inner membrane component domain
F3K22_RS25300	COG1666	GTP binding
F3K22_RS25315	COG0702	epimerase
F3K22_RS25325	COG0402	S-adenosylhomocysteine deaminase activity
F3K22_RS25340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F3K22_RS25345	COG2030	dehydratase
F3K22_RS25355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F3K22_RS25360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3K22_RS25365	COG0436	Aminotransferase
F3K22_RS25385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F3K22_RS25390	COG0081	regulation of translation
F3K22_RS25400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F3K22_RS25405	COG0222	ribosome binding
F3K22_RS25410	COG0085	RNA polymerase activity
F3K22_RS25415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F3K22_RS25425	COG2815	serine threonine protein kinase
F3K22_RS25425	COG0515	serine threonine protein kinase
F3K22_RS25430	COG0515	serine threonine protein kinase
F3K22_RS25430	COG2815	serine threonine protein kinase
F3K22_RS25445	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F3K22_RS25450	COG0049	tRNA binding
F3K22_RS25455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F3K22_RS25460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F3K22_RS25525	COG0051	transcription antitermination factor activity, RNA binding
F3K22_RS25530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F3K22_RS25535	COG0088	Forms part of the polypeptide exit tunnel
F3K22_RS25545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F3K22_RS25550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F3K22_RS25555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F3K22_RS25560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F3K22_RS25565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F3K22_RS25570	COG0255	Belongs to the universal ribosomal protein uL29 family
F3K22_RS25575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F3K22_RS25580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F3K22_RS25585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F3K22_RS25590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F3K22_RS25595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F3K22_RS25600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F3K22_RS25605	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F3K22_RS25610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F3K22_RS25615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F3K22_RS25620	COG1841	ribosomal large subunit assembly
F3K22_RS25625	COG0200	Binds to the 23S rRNA
F3K22_RS25635	COG0563	adenylate kinase activity
F3K22_RS25645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F3K22_RS25650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F3K22_RS25655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F3K22_RS25660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F3K22_RS25665	COG0202	RNA polymerase activity
F3K22_RS25670	COG0203	ribosomal protein L17
F3K22_RS25675	COG0101	tRNA pseudouridine synthase activity
F3K22_RS25685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F3K22_RS25690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F3K22_RS25695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3K22_RS25705	COG1072	(Pantothenic acid kinase))
F3K22_RS25720	COG0736	holo-[acyl-carrier-protein] synthase activity
F3K22_RS25725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3K22_RS25735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F3K22_RS25740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS25745	COG0802	atpase or kinase
F3K22_RS25765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F3K22_RS25790	COG1472	Belongs to the glycosyl hydrolase 3 family
F3K22_RS25800	COG1175	transmembrane transport
F3K22_RS25805	COG1653	transport
F3K22_RS25820	COG1316	TRANSCRIPTIONal
F3K22_RS25830	COG4941	Belongs to the sigma-70 factor family
F3K22_RS25840	COG0726	polysaccharide deacetylase
F3K22_RS25845	COG0726	polysaccharide deacetylase
F3K22_RS25850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F3K22_RS25855	COG0459	protein refolding
F3K22_RS25865	COG4221	oxidoreductase activity
F3K22_RS25875	COG0583	DNA-binding transcription factor activity
F3K22_RS25890	COG1595	DNA-templated transcription, initiation
F3K22_RS25900	COG0516	GMP reductase activity
F3K22_RS25910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F3K22_RS25925	COG0515	serine threonine protein kinase
F3K22_RS25935	COG0515	serine threonine protein kinase
F3K22_RS25950	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS25970	COG0519	Catalyzes the synthesis of GMP from XMP
F3K22_RS25970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F3K22_RS26010	COG2197	response regulator
F3K22_RS26015	COG0791	NLP P60 protein
F3K22_RS26035	COG0739	heme binding
F3K22_RS26045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS26045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS26060	COG0714	Associated with various cellular activities
F3K22_RS26070	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F3K22_RS26080	COG0045	succinate-CoA ligase (ADP-forming) activity
F3K22_RS26110	COG0138	bifunctional purine biosynthesis protein purh
F3K22_RS26125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F3K22_RS26140	COG0039	L-malate dehydrogenase activity
F3K22_RS26155	COG0754	glutathionylspermidine amidase activity
F3K22_RS26160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3K22_RS26175	COG1595	DNA-templated transcription, initiation
F3K22_RS26180	COG0180	Tryptophanyl-tRNA synthetase
F3K22_RS26215	COG1686	Belongs to the peptidase S11 family
F3K22_RS26225	COG1408	metallophosphoesterase
F3K22_RS26240	COG1309	transcriptional regulator
F3K22_RS26295	COG1053	succinate dehydrogenase
F3K22_RS26305	COG2009	succinate dehydrogenase
F3K22_RS26340	COG1595	DNA-templated transcription, initiation
F3K22_RS26350	COG1595	DNA-templated transcription, initiation
F3K22_RS26365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS26365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS26405	COG1216	Glycosyl transferase, family 2
F3K22_RS26420	COG2089	acid synthase
F3K22_RS26435	COG1473	amidohydrolase
F3K22_RS26435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F3K22_RS26440	COG1744	ABC transporter substrate-binding protein PnrA-like
F3K22_RS26445	COG1744	ABC transporter substrate-binding protein PnrA-like
F3K22_RS26450	COG3845	ABC transporter
F3K22_RS26455	COG4603	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS26460	COG1079	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS26485	COG2814	Major facilitator Superfamily
F3K22_RS26490	COG0583	DNA-binding transcription factor activity
F3K22_RS26500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3K22_RS26525	COG2205	protein histidine kinase activity
F3K22_RS26530	COG0745	RESPONSE REGULATOR receiver
F3K22_RS26535	COG1595	DNA-templated transcription, initiation
F3K22_RS26550	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS26555	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS26560	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F3K22_RS26575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3K22_RS26605	COG4770	biotin carboxylase activity
F3K22_RS26615	COG0424	maF-like protein
F3K22_RS26625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3K22_RS26635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F3K22_RS26645	COG1024	Enoyl-CoA hydratase
F3K22_RS26655	COG2986	histidine ammonia-lyase
F3K22_RS26680	COG1136	(ABC) transporter
F3K22_RS26685	COG1404	Belongs to the peptidase S8 family
F3K22_RS26695	COG1064	alcohol dehydrogenase
F3K22_RS26700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3K22_RS26710	COG0501	Belongs to the peptidase M48B family
F3K22_RS26735	COG2255	four-way junction helicase activity
F3K22_RS26740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F3K22_RS26745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F3K22_RS26755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F3K22_RS27205	COG1331	Highly conserved protein containing a thioredoxin domain
F3K22_RS27230	COG1846	Transcriptional regulator
F3K22_RS27235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3K22_RS27240	COG2132	Multicopper oxidase
F3K22_RS27255	COG1309	transcriptional regulator
F3K22_RS27275	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F3K22_RS27345	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F3K22_RS27360	COG1414	Transcriptional regulator
F3K22_RS27365	COG0251	oxidation-reduction process
F3K22_RS27445	COG3851	Histidine kinase
F3K22_RS27470	COG2885	chlorophyll binding
F3K22_RS27490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F3K22_RS27495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3K22_RS27510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3K22_RS27520	COG1136	(ABC) transporter
F3K22_RS27530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3K22_RS27545	COG0114	fumarate hydratase activity
F3K22_RS27560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F3K22_RS27560	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F3K22_RS27585	COG0778	Nitroreductase
F3K22_RS27590	COG1722	exodeoxyribonuclease VII activity
F3K22_RS27595	COG1570	exodeoxyribonuclease VII activity
F3K22_RS27600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F3K22_RS27615	COG0012	GTP binding
F3K22_RS27660	COG1061	Type III restriction enzyme res subunit
F3K22_RS27680	COG0519	Catalyzes the synthesis of GMP from XMP
F3K22_RS27700	COG3547	Transposase (IS116 IS110 IS902 family)
F3K22_RS27710	COG0305	Participates in initiation and elongation during chromosome replication
F3K22_RS27815	COG0714	Associated with various cellular activities
F3K22_RS28015	COG0151	Belongs to the GarS family
F3K22_RS28055	COG1793	dna ligase
F3K22_RS28070	COG0515	serine threonine protein kinase
F3K22_RS28070	COG2815	serine threonine protein kinase
F3K22_RS28280	COG2018	Roadblock/LC7 domain
F3K22_RS28320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F3K22_RS28355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F3K22_RS28375	COG0582	viral genome integration into host DNA
F3K22_RS28390	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
F3K22_RS28415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS28465	COG0133	tryptophan synthase activity
F3K22_RS28505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F3K22_RS28510	COG1053	succinate dehydrogenase
F3K22_RS28535	COG1217	gtp-binding protein TYPA
F3K22_RS28540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3K22_RS28545	COG0747	negative chemotaxis
F3K22_RS28550	COG0601	transmembrane transport
F3K22_RS28555	COG0444	Belongs to the ABC transporter superfamily
F3K22_RS28560	COG4608	Belongs to the ABC transporter superfamily
F3K22_RS28575	COG4166	transmembrane transport
F3K22_RS28580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3K22_RS28590	COG0601	transmembrane transport
F3K22_RS28595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3K22_RS28600	COG0444	Belongs to the ABC transporter superfamily
F3K22_RS28605	COG4608	Belongs to the ABC transporter superfamily
F3K22_RS28620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F3K22_RS28635	COG1131	(ABC) transporter
F3K22_RS28645	COG4585	Histidine kinase
F3K22_RS28650	COG2197	response regulator
F3K22_RS28685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3K22_RS28695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F3K22_RS28705	COG2818	Glycosylase
F3K22_RS28710	COG1024	Enoyl-CoA hydratase
F3K22_RS28725	COG1595	DNA-templated transcription, initiation
F3K22_RS28735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3K22_RS28740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F3K22_RS28775	COG0598	Magnesium transport protein CorA
F3K22_RS28795	COG2095	MarC family integral membrane protein
F3K22_RS28805	COG1432	Conserved Protein
F3K22_RS28885	COG0596	Alpha beta hydrolase
F3K22_RS28910	COG0210	DNA helicase
F3K22_RS28955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F3K22_RS29010	COG3480	Lon protease (S16) C-terminal proteolytic domain
F3K22_RS29020	COG1615	UPF0182 protein
F3K22_RS29050	COG0483	inositol monophosphate 1-phosphatase activity
F3K22_RS29070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F3K22_RS29080	COG2135	peptidase activity
F3K22_RS29090	COG1595	DNA-templated transcription, initiation
F3K22_RS29095	COG5662	AntiSigma factor
F3K22_RS29130	COG0242	peptide deformylase activity
F3K22_RS29155	COG1957	nucleoside hydrolase
F3K22_RS29175	COG2188	Transcriptional regulator
F3K22_RS29185	COG1175	transmembrane transport
F3K22_RS29190	COG0395	ABC-type sugar transport system, permease component
F3K22_RS29195	COG1472	Belongs to the glycosyl hydrolase 3 family
F3K22_RS29200	COG0363	glucosamine-6-phosphate deaminase activity
F3K22_RS29215	COG1597	lipid kinase activity
F3K22_RS29255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3K22_RS29260	COG0142	geranyltranstransferase activity
F3K22_RS29280	COG4977	sequence-specific DNA binding
F3K22_RS29285	COG0395	ABC-type sugar transport system, permease component
F3K22_RS29290	COG1175	transmembrane transport
F3K22_RS29300	COG1609	Transcriptional regulator
F3K22_RS29365	COG0582	viral genome integration into host DNA
F3K22_RS29390	COG1126	abc transporter atp-binding protein
F3K22_RS29400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3K22_RS29410	COG0604	alcohol dehydrogenase
F3K22_RS29445	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3K22_RS29445	COG0567	Dehydrogenase, E1 component
F3K22_RS29450	COG2205	protein histidine kinase activity
F3K22_RS29455	COG0745	RESPONSE REGULATOR receiver
F3K22_RS29470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F3K22_RS29540	COG0768	penicillin binding
F3K22_RS29555	COG2205	protein histidine kinase activity
F3K22_RS29575	COG3285	dna ligase
F3K22_RS29575	COG1793	dna ligase
F3K22_RS29580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F3K22_RS29585	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F3K22_RS29630	COG0745	RESPONSE REGULATOR receiver
F3K22_RS29635	COG0018	arginyl-trna synthetase
F3K22_RS29635	COG0018	arginyl-trna synthetase
F3K22_RS29640	COG0019	diaminopimelate decarboxylase activity
F3K22_RS29645	COG0460	homoserine dehydrogenase
F3K22_RS29650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F3K22_RS29655	COG0083	homoserine kinase activity
F3K22_RS29675	COG0254	rRNA binding
F3K22_RS29680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F3K22_RS29685	COG2890	protein-(glutamine-N5) methyltransferase activity
F3K22_RS29695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3K22_RS29700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3K22_RS29720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F3K22_RS29725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F3K22_RS29730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F3K22_RS29735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F3K22_RS29740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F3K22_RS29745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F3K22_RS29750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F3K22_RS29765	COG2197	response regulator
F3K22_RS29770	COG4585	Histidine kinase
F3K22_RS29800	COG1309	transcriptional regulator
F3K22_RS29805	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS29820	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F3K22_RS29855	COG1131	(ABC) transporter
F3K22_RS29875	COG0183	Belongs to the thiolase family
F3K22_RS29895	COG0745	RESPONSE REGULATOR receiver
F3K22_RS29900	COG0642	Histidine kinase
F3K22_RS29965	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS29965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS30000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F3K22_RS30005	COG0857	belongs to the CobB CobQ family
F3K22_RS30005	COG0280	phosphate acetyltransferase
F3K22_RS30010	COG0205	6-phosphofructokinase activity
F3K22_RS30025	COG3903	Transcriptional regulator
F3K22_RS30025	COG3629	intracellular signal transduction
F3K22_RS30030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F3K22_RS30040	COG0395	ABC-type sugar transport system, permease component
F3K22_RS30045	COG1175	transmembrane transport
F3K22_RS30055	COG3903	Transcriptional regulator
F3K22_RS30055	COG3629	intracellular signal transduction
F3K22_RS30060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F3K22_RS30070	COG4565	transcriptional regulatory protein
F3K22_RS30075	COG3290	protein histidine kinase activity
F3K22_RS30080	COG1301	dicarboxylic acid transport
F3K22_RS30085	COG0789	Transcriptional regulator
F3K22_RS30090	COG0492	ferredoxin-NADP+ reductase activity
F3K22_RS30090	COG3118	belongs to the thioredoxin family
F3K22_RS30105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F3K22_RS30110	COG3281	Trehalose synthase
F3K22_RS30115	COG0366	Alpha amylase catalytic
F3K22_RS30120	COG0366	Alpha amylase catalytic
F3K22_RS30130	COG0058	SHG alpha-glucan phosphorylase activity
F3K22_RS30150	COG1132	(ABC) transporter
F3K22_RS30155	COG1132	(ABC) transporter
F3K22_RS30160	COG1132	(ABC) transporter
F3K22_RS30165	COG1132	(ABC) transporter
F3K22_RS30170	COG1131	(ABC) transporter
F3K22_RS30180	COG4585	Histidine kinase
F3K22_RS30185	COG2197	response regulator
F3K22_RS30200	COG1376	ErfK ybiS ycfS ynhG family protein
F3K22_RS30235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3K22_RS30240	COG3409	Peptidoglycan-binding domain 1 protein
F3K22_RS30240	COG3757	hydrolase, family 25
F3K22_RS30315	COG0464	growth
F3K22_RS30365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F3K22_RS30370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F3K22_RS30380	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
F3K22_RS30385	COG1760	l-serine dehydratase
F3K22_RS30390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3K22_RS30395	COG0509	glycine decarboxylation via glycine cleavage system
F3K22_RS30400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3K22_RS30420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3K22_RS30425	COG0747	negative chemotaxis
F3K22_RS30435	COG0444	Belongs to the ABC transporter superfamily
F3K22_RS30440	COG4608	Belongs to the ABC transporter superfamily
F3K22_RS30445	COG2860	membrane
F3K22_RS30455	COG1309	transcriptional regulator
F3K22_RS30475	COG3023	N-Acetylmuramoyl-L-alanine amidase
F3K22_RS30480	COG0482	sulfurtransferase activity
F3K22_RS30495	COG4221	oxidoreductase activity
F3K22_RS30505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F3K22_RS30515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F3K22_RS30520	COG0154	amidase activity
F3K22_RS30530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F3K22_RS30535	COG2409	Drug exporters of the RND superfamily
F3K22_RS30540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3K22_RS30555	COG2197	response regulator
F3K22_RS30570	COG0667	Aldo Keto reductase
F3K22_RS30580	COG5001	Diguanylate cyclase
F3K22_RS30590	COG0440	acetolactate synthase activity
F3K22_RS30595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F3K22_RS30600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3K22_RS30605	COG2197	response regulator
F3K22_RS30610	COG0515	serine threonine protein kinase
F3K22_RS30610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3K22_RS30620	COG0506	proline dehydrogenase activity
F3K22_RS30625	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS30635	COG0473	3-isopropylmalate dehydrogenase activity
F3K22_RS30640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F3K22_RS30645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3K22_RS30655	COG0832	Belongs to the urease beta subunit family
F3K22_RS30655	COG0831	urea catabolic process
F3K22_RS30660	COG0804	urea catabolic process
F3K22_RS30665	COG2957	Belongs to the agmatine deiminase family
F3K22_RS30670	COG1309	transcriptional regulator
F3K22_RS30675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3K22_RS30715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3K22_RS30735	COG2018	Roadblock/LC7 domain
F3K22_RS30755	COG2018	Roadblock/LC7 domain
F3K22_RS30760	COG5002	protein histidine kinase activity
F3K22_RS30770	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3K22_RS30775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F3K22_RS30820	COG1414	Transcriptional regulator
F3K22_RS30825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F3K22_RS30830	COG0066	3-isopropylmalate dehydratase activity
F3K22_RS30840	COG0776	regulation of translation
F3K22_RS30850	COG1920	GTP binding
F3K22_RS30860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F3K22_RS30865	COG1181	Belongs to the D-alanine--D-alanine ligase family
F3K22_RS30885	COG0351	phosphomethylpyrimidine kinase
F3K22_RS30890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F3K22_RS30895	COG1461	Dihydroxyacetone kinase
F3K22_RS30905	COG0326	Molecular chaperone. Has ATPase activity
F3K22_RS30915	COG0742	ribosomal rna small subunit methyltransferase
F3K22_RS30920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F3K22_RS30935	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F3K22_RS30940	COG0571	ribonuclease III activity
F3K22_RS30945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3K22_RS30950	COG1733	regulation of RNA biosynthetic process
F3K22_RS30955	COG2340	Cysteine-rich secretory protein family
F3K22_RS30960	COG1254	Belongs to the acylphosphatase family
F3K22_RS30970	COG1196	nuclear chromosome segregation
F3K22_RS30975	COG0477	Major facilitator Superfamily
F3K22_RS31015	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F3K22_RS31030	COG0442	prolyl-tRNA aminoacylation
F3K22_RS31040	COG0228	four-way junction DNA binding
F3K22_RS31045	COG1837	Belongs to the UPF0109 family
F3K22_RS31050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F3K22_RS31055	COG0336	Belongs to the RNA methyltransferase TrmD family
F3K22_RS31060	COG0335	large ribosomal subunit rRNA binding
F3K22_RS31075	COG0681	Belongs to the peptidase S26 family
F3K22_RS31080	COG0681	Belongs to the peptidase S26 family
F3K22_RS31085	COG0494	nUDIX hydrolase
F3K22_RS31095	COG0792	nuclease activity
F3K22_RS31110	COG1191	sigma factor activity
F3K22_RS31120	COG4942	peptidase
F3K22_RS31125	COG0052	Belongs to the universal ribosomal protein uS2 family
F3K22_RS31130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F3K22_RS31135	COG0528	UMP kinase activity
F3K22_RS31140	COG0233	cytoplasmic translational termination
F3K22_RS31145	COG0575	Belongs to the CDS family
F3K22_RS31160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F3K22_RS31170	COG4208	sulfate ABC transporter
F3K22_RS31175	COG3842	ATPase activity
F3K22_RS31205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3K22_RS31215	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS31220	COG2353	YceI-like domain
F3K22_RS31235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3K22_RS31260	COG3842	ATPase activity
F3K22_RS31270	COG1177	transmembrane transport
F3K22_RS31275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3K22_RS31300	COG2508	Transcriptional regulator
F3K22_RS31305	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS31310	COG1472	Belongs to the glycosyl hydrolase 3 family
F3K22_RS31315	COG1653	transport
F3K22_RS31320	COG4209	transmembrane transport
F3K22_RS31325	COG0395	ABC-type sugar transport system, permease component
F3K22_RS31345	COG1609	Transcriptional regulator
F3K22_RS31360	COG0628	permease
F3K22_RS31385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F3K22_RS31390	COG0750	zinc metalloprotease
F3K22_RS31395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F3K22_RS31410	COG0442	prolyl-tRNA aminoacylation
F3K22_RS31430	COG0779	Required for maturation of 30S ribosomal subunits
F3K22_RS31445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F3K22_RS31455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F3K22_RS31460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F3K22_RS31475	COG0455	bacterial-type flagellum organization
F3K22_RS31485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F3K22_RS31490	COG1185	polyribonucleotide nucleotidyltransferase activity
F3K22_RS31495	COG0612	Peptidase, M16
F3K22_RS31500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F3K22_RS31515	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F3K22_RS31520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS31525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F3K22_RS31555	COG2208	phosphoserine phosphatase activity
F3K22_RS31555	COG2770	Histidine kinase
F3K22_RS31560	COG4999	Histidine kinase
F3K22_RS31560	COG3850	Histidine kinase
F3K22_RS31560	COG2205	protein histidine kinase activity
F3K22_RS31560	COG3437	response regulator, receiver
F3K22_RS31570	COG1674	ftsk spoiiie
F3K22_RS31580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3K22_RS31590	COG1058	Belongs to the CinA family
F3K22_RS31590	COG1546	Belongs to the CinA family
F3K22_RS31595	COG1396	sequence-specific DNA binding
F3K22_RS31600	COG0783	Belongs to the Dps family
F3K22_RS31605	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS31610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3K22_RS31615	COG1201	RNA secondary structure unwinding
F3K22_RS31620	COG2207	Transcriptional regulator
F3K22_RS31650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F3K22_RS31665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3K22_RS31670	COG0765	amino acid transport
F3K22_RS31675	COG0765	amino acid transport
F3K22_RS31680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3K22_RS31685	COG1126	abc transporter atp-binding protein
F3K22_RS31690	COG0745	RESPONSE REGULATOR receiver
F3K22_RS31695	COG2205	protein histidine kinase activity
F3K22_RS31710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3K22_RS31740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F3K22_RS31745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F3K22_RS31755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F3K22_RS31785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F3K22_RS31790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F3K22_RS31795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F3K22_RS31835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F3K22_RS31850	COG0514	ATP-dependent DNA helicase (RecQ)
F3K22_RS31870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F3K22_RS31875	COG2186	Transcriptional regulator
F3K22_RS31900	COG0187	DNA topoisomerase II activity
F3K22_RS31910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3K22_RS31915	COG4565	transcriptional regulatory protein
F3K22_RS31920	COG3290	protein histidine kinase activity
F3K22_RS31945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3K22_RS31950	COG0612	Peptidase, M16
F3K22_RS31965	COG1802	Transcriptional regulator
F3K22_RS31970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3K22_RS31975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3K22_RS31975	COG0045	succinate-CoA ligase (ADP-forming) activity
F3K22_RS31975	COG1042	CoA-binding domain protein
F3K22_RS31990	COG1435	thymidine kinase activity
F3K22_RS32020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F3K22_RS32035	COG0745	RESPONSE REGULATOR receiver
F3K22_RS32040	COG2205	protein histidine kinase activity
F3K22_RS32065	COG0756	dUTP diphosphatase activity
F3K22_RS32100	COG0569	domain protein
F3K22_RS32105	COG0531	amino acid
F3K22_RS32110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F3K22_RS32200	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS32210	COG1454	alcohol dehydrogenase
F3K22_RS32215	COG3485	protocatechuate 3,4-dioxygenase
F3K22_RS32230	COG1090	epimerase
F3K22_RS32260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F3K22_RS32275	COG1215	transferase activity, transferring glycosyl groups
F3K22_RS32285	COG4310	Domain of unknown function (DUF2172)
F3K22_RS32300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F3K22_RS32355	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F3K22_RS32360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F3K22_RS32385	COG0243	molybdopterin cofactor binding
F3K22_RS32390	COG1799	cell septum assembly
F3K22_RS32425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F3K22_RS32430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3K22_RS32445	COG2235	arginine
F3K22_RS32450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F3K22_RS32515	COG1585	Membrane protein implicated in regulation of membrane protease activity
F3K22_RS32520	COG2268	Band 7 protein
F3K22_RS32525	COG0475	glutathione-regulated potassium exporter activity
F3K22_RS32570	COG2197	response regulator
F3K22_RS32585	COG0596	Alpha beta hydrolase
F3K22_RS32595	COG1609	Transcriptional regulator
F3K22_RS32605	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS32620	COG3250	beta-galactosidase activity
F3K22_RS32645	COG3250	beta-galactosidase activity
F3K22_RS32975	COG0151	Belongs to the GarS family
F3K22_RS32980	COG0738	Major facilitator superfamily
F3K22_RS33125	COG0154	amidase activity
F3K22_RS33135	COG3547	Transposase (IS116 IS110 IS902 family)
F3K22_RS33145	COG1051	belongs to the nudix hydrolase family
F3K22_RS33175	COG0174	glutamine synthetase
F3K22_RS33265	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F3K22_RS33335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F3K22_RS33365	COG1205	dead DEAH box helicase
F3K22_RS33365	COG1111	helicase
F3K22_RS33375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F3K22_RS33380	COG0515	serine threonine protein kinase
F3K22_RS33380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3K22_RS33430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3K22_RS33445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F3K22_RS33465	COG1653	transport
F3K22_RS33470	COG1175	transmembrane transport
F3K22_RS33475	COG0395	ABC-type sugar transport system, permease component
F3K22_RS33480	COG1940	carbohydrate kinase activity
F3K22_RS33485	COG4213	ABC transporter substrate-binding protein
F3K22_RS33495	COG4214	carbohydrate transport
F3K22_RS33500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F3K22_RS33505	COG0531	amino acid
F3K22_RS33515	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS33515	COG1024	Enoyl-CoA hydratase
F3K22_RS33520	COG0183	Belongs to the thiolase family
F3K22_RS33525	COG1609	Transcriptional regulator
F3K22_RS33535	COG2182	Extracellular solute-binding protein
F3K22_RS33540	COG1175	transmembrane transport
F3K22_RS33545	COG0395	ABC-type sugar transport system, permease component
F3K22_RS33550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F3K22_RS33565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F3K22_RS33580	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3K22_RS33590	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F3K22_RS33595	COG3253	May function as heme-dependent peroxidase
F3K22_RS33615	COG3220	belongs to the UPF0276 family
F3K22_RS33650	COG0726	polysaccharide deacetylase
F3K22_RS33675	COG0330	HflC and HflK could
F3K22_RS33705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F3K22_RS33710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3K22_RS33725	COG3903	Transcriptional regulator
F3K22_RS33725	COG3629	intracellular signal transduction
F3K22_RS33730	COG3629	intracellular signal transduction
F3K22_RS33730	COG3903	Transcriptional regulator
F3K22_RS33740	COG0456	acetyltransferase
F3K22_RS33760	COG1609	Transcriptional regulator
F3K22_RS33785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3K22_RS33795	COG2018	Roadblock/LC7 domain
F3K22_RS33805	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS33895	COG1404	Belongs to the peptidase S8 family
F3K22_RS33915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3K22_RS34005	COG2409	Drug exporters of the RND superfamily
F3K22_RS34025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3K22_RS34030	COG1116	anion transmembrane transporter activity
F3K22_RS34055	COG0529	Catalyzes the synthesis of activated sulfate
F3K22_RS34060	COG0175	sulfate reduction
F3K22_RS34090	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS34095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3K22_RS34110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS34140	COG1609	Transcriptional regulator
F3K22_RS34150	COG2040	homocysteine
F3K22_RS34155	COG0531	amino acid
F3K22_RS34180	COG2755	lipolytic protein G-D-S-L family
F3K22_RS34220	COG0395	ABC-type sugar transport system, permease component
F3K22_RS34225	COG1175	transmembrane transport
F3K22_RS34240	COG0277	FAD linked oxidase domain protein
F3K22_RS34245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3K22_RS34265	COG2267	carboxylic ester hydrolase activity
F3K22_RS34270	COG1162	GTPase activity
F3K22_RS34325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3K22_RS34330	COG2252	PERMEase
F3K22_RS34355	COG0673	inositol 2-dehydrogenase activity
F3K22_RS34365	COG1175	transmembrane transport
F3K22_RS34370	COG0395	ABC-type sugar transport system, permease component
F3K22_RS34390	COG0596	Alpha beta hydrolase
F3K22_RS34395	COG1609	Transcriptional regulator
F3K22_RS34400	COG0673	inositol 2-dehydrogenase activity
F3K22_RS34405	COG2188	Transcriptional regulator
F3K22_RS34410	COG3962	Belongs to the TPP enzyme family
F3K22_RS34435	COG0641	radical SAM
F3K22_RS34460	COG0515	serine threonine protein kinase
F3K22_RS34465	COG3467	pyridoxamine 5'-phosphate
F3K22_RS34485	COG0657	acetylesterase activity
F3K22_RS34500	COG2936	dipeptidyl-peptidase activity
F3K22_RS34510	COG4585	Histidine kinase
F3K22_RS34525	COG1609	Transcriptional regulator
F3K22_RS34550	COG1175	transmembrane transport
F3K22_RS34555	COG0395	ABC-type sugar transport system, permease component
F3K22_RS34560	COG3507	Belongs to the glycosyl hydrolase 43 family
F3K22_RS34570	COG0598	Magnesium transport protein CorA
F3K22_RS34590	COG2197	response regulator
F3K22_RS34595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3K22_RS34600	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS34610	COG3960	tartronate-semialdehyde synthase activity
F3K22_RS34615	COG2084	Dehydrogenase
F3K22_RS34620	COG3622	Belongs to the hyi family
F3K22_RS34640	COG2351	hydroxyisourate hydrolase activity
F3K22_RS34685	COG0436	Aminotransferase
F3K22_RS34690	COG1733	regulation of RNA biosynthetic process
F3K22_RS34705	COG4264	IucA IucC family
F3K22_RS34725	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F3K22_RS34740	COG1414	Transcriptional regulator
F3K22_RS34745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3K22_RS34750	COG4266	Belongs to the allantoicase family
F3K22_RS34770	COG0667	Aldo Keto reductase
F3K22_RS34775	COG2197	response regulator
F3K22_RS34785	COG0673	inositol 2-dehydrogenase activity
F3K22_RS34790	COG2188	Transcriptional regulator
F3K22_RS34795	COG1940	carbohydrate kinase activity
F3K22_RS34805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F3K22_RS34815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3K22_RS34820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3K22_RS34840	COG1126	abc transporter atp-binding protein
F3K22_RS34860	COG0405	Gamma-glutamyltransferase
F3K22_RS34885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F3K22_RS34900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3K22_RS34910	COG1953	Uracil, thiamine, allantoin
F3K22_RS34920	COG2226	methyltransferase
F3K22_RS34930	COG0483	inositol monophosphate 1-phosphatase activity
F3K22_RS34945	COG1082	Xylose isomerase domain protein TIM barrel
F3K22_RS34980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F3K22_RS34990	COG0640	Transcriptional regulator
F3K22_RS35010	COG2197	response regulator
F3K22_RS35025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F3K22_RS35045	COG1929	Belongs to the glycerate kinase type-1 family
F3K22_RS35060	COG0688	phosphatidylethanolamine metabolic process
F3K22_RS35065	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS35080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS35080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS35085	COG0604	alcohol dehydrogenase
F3K22_RS35095	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS35135	COG2226	methyltransferase
F3K22_RS35140	COG2362	D-Aminopeptidase
F3K22_RS35145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3K22_RS35150	COG0823	Involved in the tonB-independent uptake of proteins
F3K22_RS35150	COG1506	peptidase
F3K22_RS35150	COG4946	Tricorn protease homolog
F3K22_RS35155	COG1619	proteins homologs of microcin C7 resistance protein MccF
F3K22_RS35175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS35185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F3K22_RS35190	COG1793	dna ligase
F3K22_RS35190	COG3285	dna ligase
F3K22_RS35260	COG0488	(ABC) transporter
F3K22_RS35280	COG0693	protein deglycase activity
F3K22_RS35290	COG0028	Belongs to the TPP enzyme family
F3K22_RS35320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3K22_RS35340	COG0443	Heat shock 70 kDa protein
F3K22_RS35355	COG2154	pterin-4-alpha-carbinolamine dehydratase
F3K22_RS35365	COG3401	FG-GAP repeat protein
F3K22_RS35380	COG5297	Belongs to the glycosyl hydrolase family 6
F3K22_RS35380	COG4733	cellulase activity
F3K22_RS35385	COG5297	Belongs to the glycosyl hydrolase family 6
F3K22_RS35405	COG0656	L-ascorbic acid biosynthetic process
F3K22_RS35415	COG1022	Amp-dependent synthetase and ligase
F3K22_RS35435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F3K22_RS35450	COG3383	formate dehydrogenase (NAD+) activity
F3K22_RS35455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F3K22_RS35485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3K22_RS35495	COG1940	carbohydrate kinase activity
F3K22_RS35500	COG1129	ABC transporter
F3K22_RS35505	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS35515	COG0673	inositol 2-dehydrogenase activity
F3K22_RS35575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3K22_RS35585	COG0045	succinate-CoA ligase (ADP-forming) activity
F3K22_RS35595	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS35610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F3K22_RS35710	COG0673	inositol 2-dehydrogenase activity
F3K22_RS35715	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS35720	COG1609	Transcriptional regulator
F3K22_RS35725	COG4977	sequence-specific DNA binding
F3K22_RS35735	COG1183	phosphatidylcholine synthase activity
F3K22_RS35750	COG0438	transferase activity, transferring glycosyl groups
F3K22_RS35765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3K22_RS35795	COG0477	Major facilitator Superfamily
F3K22_RS35810	COG0477	Major facilitator Superfamily
F3K22_RS35820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3K22_RS35825	COG1082	Xylose isomerase domain protein TIM barrel
F3K22_RS35825	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F3K22_RS35835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F3K22_RS35850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F3K22_RS35875	COG0765	amino acid transport
F3K22_RS35885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F3K22_RS35925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F3K22_RS35935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F3K22_RS35940	COG0395	ABC-type sugar transport system, permease component
F3K22_RS35955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3K22_RS35960	COG1486	melibiose metabolic process
F3K22_RS35975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F3K22_RS36020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3K22_RS36025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3K22_RS36035	COG1414	Transcriptional regulator
F3K22_RS36055	COG3511	phospholipase C
F3K22_RS36085	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F3K22_RS36085	COG1672	PFAM Archaeal ATPase
F3K22_RS36090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3K22_RS36095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F3K22_RS36100	COG3485	protocatechuate 3,4-dioxygenase
F3K22_RS36105	COG3485	protocatechuate 3,4-dioxygenase
F3K22_RS36125	COG1793	dna ligase
F3K22_RS36200	COG1834	amidinotransferase
F3K22_RS36205	COG0488	(ABC) transporter
F3K22_RS36220	COG1515	deoxyribonuclease V activity
F3K22_RS36230	COG3268	Saccharopine dehydrogenase
F3K22_RS36235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3K22_RS36245	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3K22_RS36245	COG1024	Enoyl-CoA hydratase
F3K22_RS36255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F3K22_RS36260	COG2936	dipeptidyl-peptidase activity
F3K22_RS36270	COG1609	Transcriptional regulator
F3K22_RS36275	COG1879	ABC-type sugar transport system periplasmic component
F3K22_RS36280	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS36290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3K22_RS36295	COG1869	D-ribose catabolic process
F3K22_RS36305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F3K22_RS36320	COG0488	(ABC) transporter
F3K22_RS36325	COG2183	response to ionizing radiation
F3K22_RS36340	COG4977	sequence-specific DNA binding
F3K22_RS36350	COG1024	Enoyl-CoA hydratase
F3K22_RS36360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F3K22_RS36390	COG0371	Dehydrogenase
F3K22_RS36410	COG1134	teichoic acid transport
F3K22_RS36415	COG1562	ergosterol biosynthetic process
F3K22_RS36425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F3K22_RS36435	COG1657	PFAM Prenyltransferase squalene oxidase
F3K22_RS36450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F3K22_RS36455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F3K22_RS36475	COG2365	Tyrosine phosphatase family
F3K22_RS36495	COG2755	lipolytic protein G-D-S-L family
F3K22_RS36500	COG0456	acetyltransferase
F3K22_RS36500	COG1846	Transcriptional regulator
F3K22_RS36505	COG0657	acetylesterase activity
F3K22_RS36520	COG0300	oxidoreductase activity
F3K22_RS36530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F3K22_RS36570	COG1063	alcohol dehydrogenase
F3K22_RS36575	COG0156	8-amino-7-oxononanoate synthase activity
F3K22_RS36580	COG0583	DNA-binding transcription factor activity
F3K22_RS36610	COG3938	Belongs to the proline racemase family
F3K22_RS36615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3K22_RS36640	COG3387	PFAM Glycoside hydrolase 15-related
F3K22_RS36660	COG1126	abc transporter atp-binding protein
F3K22_RS36685	COG0402	S-adenosylhomocysteine deaminase activity
F3K22_RS36700	COG2267	carboxylic ester hydrolase activity
F3K22_RS36725	COG3284	Transcriptional regulator
F3K22_RS36740	COG1454	alcohol dehydrogenase
F3K22_RS36750	COG0641	radical SAM
F3K22_RS36760	COG3903	Transcriptional regulator
F3K22_RS36760	COG3629	intracellular signal transduction
F3K22_RS36785	COG3345	alpha-galactosidase
F3K22_RS36800	COG1846	Transcriptional regulator
F3K22_RS36805	COG2838	Isocitrate dehydrogenase
F3K22_RS36810	COG0668	transmembrane transport
F3K22_RS36820	COG1132	(ABC) transporter
F3K22_RS36830	COG4166	transmembrane transport
F3K22_RS36840	COG0655	NAD(P)H dehydrogenase (quinone) activity
F3K22_RS36845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3K22_RS36890	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS36935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3K22_RS36935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3K22_RS36955	COG0277	FAD linked oxidase domain protein
F3K22_RS36970	COG1834	amidinotransferase
F3K22_RS36985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F3K22_RS37000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F3K22_RS37020	COG0297	glycogen (starch) synthase activity
F3K22_RS37025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F3K22_RS37070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3K22_RS37095	COG0589	response to stress
F3K22_RS37145	COG0583	DNA-binding transcription factor activity
F3K22_RS37155	COG1053	succinate dehydrogenase
F3K22_RS37160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F3K22_RS37175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS37190	COG1477	protein flavinylation
F3K22_RS37205	COG0745	RESPONSE REGULATOR receiver
F3K22_RS37210	COG2205	protein histidine kinase activity
F3K22_RS37215	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS37220	COG0745	RESPONSE REGULATOR receiver
F3K22_RS37240	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS37245	COG2072	flavoprotein involved in K transport
F3K22_RS37270	COG3360	Dodecin
F3K22_RS37275	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F3K22_RS37280	COG0121	glutamine amidotransferase
F3K22_RS37285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F3K22_RS37290	COG3572	ergothioneine biosynthetic process
F3K22_RS37305	COG2268	Band 7 protein
F3K22_RS37330	COG1609	Transcriptional regulator
F3K22_RS37340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F3K22_RS37350	COG0242	peptide deformylase activity
F3K22_RS37385	COG0659	secondary active sulfate transmembrane transporter activity
F3K22_RS37390	COG2824	Alkylphosphonate utilization operon protein PhnA
F3K22_RS37410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3K22_RS37415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3K22_RS37450	COG1595	DNA-templated transcription, initiation
F3K22_RS37455	COG2205	protein histidine kinase activity
F3K22_RS37460	COG0745	RESPONSE REGULATOR receiver
F3K22_RS37485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F3K22_RS37510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F3K22_RS37540	COG0574	Belongs to the PEP-utilizing enzyme family
F3K22_RS37540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3K22_RS37560	COG1063	alcohol dehydrogenase
F3K22_RS37585	COG0517	IMP dehydrogenase activity
F3K22_RS37585	COG0516	GMP reductase activity
F3K22_RS37600	COG0045	succinate-CoA ligase (ADP-forming) activity
F3K22_RS37600	COG1042	CoA-binding domain protein
F3K22_RS37600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3K22_RS37605	COG0516	GMP reductase activity
F3K22_RS37605	COG0517	IMP dehydrogenase activity
F3K22_RS37635	COG1937	Protein conserved in bacteria
F3K22_RS37640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
F3K22_RS37655	COG0516	GMP reductase activity
F3K22_RS37655	COG0517	IMP dehydrogenase activity
F3K22_RS37735	COG1063	alcohol dehydrogenase
F3K22_RS37765	COG2755	lipolytic protein G-D-S-L family
F3K22_RS37790	COG0768	penicillin binding
F3K22_RS37820	COG2197	response regulator
F3K22_RS37835	COG4585	Histidine kinase
F3K22_RS37860	COG1404	Belongs to the peptidase S8 family
F3K22_RS37895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3K22_RS37900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F3K22_RS37910	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F3K22_RS37930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3K22_RS37940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F3K22_RS37945	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS37955	COG1309	transcriptional regulator
F3K22_RS37960	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3K22_RS37975	COG4689	acetoacetate decarboxylase
F3K22_RS37990	COG0174	glutamine synthetase
F3K22_RS38000	COG1595	DNA-templated transcription, initiation
F3K22_RS38010	COG2207	Transcriptional regulator
F3K22_RS38010	COG3708	Transcriptional regulator
F3K22_RS38020	COG0673	inositol 2-dehydrogenase activity
F3K22_RS38030	COG1063	alcohol dehydrogenase
F3K22_RS38035	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS38055	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F3K22_RS38065	COG1573	uracil-dna glycosylase
F3K22_RS38075	COG1556	Lactate utilization protein
F3K22_RS38080	COG1139	Iron-sulfur cluster binding protein
F3K22_RS38085	COG0247	lactate metabolic process
F3K22_RS38090	COG1070	Carbohydrate kinase
F3K22_RS38095	COG3347	Dehydrogenase
F3K22_RS38095	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS38105	COG1129	ABC transporter
F3K22_RS38115	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS38120	COG1879	ABC-type sugar transport system periplasmic component
F3K22_RS38135	COG1609	Transcriptional regulator
F3K22_RS38155	COG1357	PFAM Pentapeptide repeats (8 copies)
F3K22_RS38165	COG1309	transcriptional regulator
F3K22_RS38175	COG2706	6-phosphogluconolactonase activity
F3K22_RS38210	COG0546	phosphoglycolate phosphatase activity
F3K22_RS38215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F3K22_RS38215	COG1796	DNA polymerase
F3K22_RS38235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F3K22_RS38250	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS38280	COG0435	Glutathione S-transferase
F3K22_RS38300	COG1846	Transcriptional regulator
F3K22_RS38315	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS38320	COG1129	ABC transporter
F3K22_RS38330	COG2197	response regulator
F3K22_RS38340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3K22_RS38355	COG2197	response regulator
F3K22_RS38430	COG0248	Ppx GppA phosphatase
F3K22_RS38440	COG0747	negative chemotaxis
F3K22_RS38485	COG2197	response regulator
F3K22_RS38495	COG1132	(ABC) transporter
F3K22_RS38505	COG0515	serine threonine protein kinase
F3K22_RS38520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F3K22_RS38565	COG1132	(ABC) transporter
F3K22_RS38595	COG3224	Antibiotic biosynthesis monooxygenase
F3K22_RS38605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3K22_RS38625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3K22_RS38640	COG1940	carbohydrate kinase activity
F3K22_RS38640	COG1846	Transcriptional regulator
F3K22_RS38670	COG2197	response regulator
F3K22_RS38675	COG3851	Histidine kinase
F3K22_RS38700	COG1940	carbohydrate kinase activity
F3K22_RS38715	COG0395	ABC-type sugar transport system, permease component
F3K22_RS38725	COG0572	uridine kinase
F3K22_RS38740	COG2340	Cysteine-rich secretory protein family
F3K22_RS38775	COG0402	S-adenosylhomocysteine deaminase activity
F3K22_RS38780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F3K22_RS38795	COG0492	ferredoxin-NADP+ reductase activity
F3K22_RS38805	COG0589	response to stress
F3K22_RS38840	COG3290	protein histidine kinase activity
F3K22_RS38845	COG4565	transcriptional regulatory protein
F3K22_RS38855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F3K22_RS38885	COG0009	L-threonylcarbamoyladenylate synthase
F3K22_RS38920	COG3290	protein histidine kinase activity
F3K22_RS38935	COG4585	Histidine kinase
F3K22_RS38940	COG2197	response regulator
F3K22_RS38970	COG2409	Drug exporters of the RND superfamily
F3K22_RS38990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F3K22_RS38995	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F3K22_RS39005	COG0181	hydroxymethylbilane synthase activity
F3K22_RS39015	COG0515	serine threonine protein kinase
F3K22_RS39015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3K22_RS39060	COG0513	Belongs to the DEAD box helicase family
F3K22_RS39090	COG2226	methyltransferase
F3K22_RS39100	COG3655	Transcriptional regulator
F3K22_RS39125	COG0395	ABC-type sugar transport system, permease component
F3K22_RS39140	COG1609	Transcriptional regulator
F3K22_RS39175	COG1609	Transcriptional regulator
F3K22_RS39190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F3K22_RS39195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F3K22_RS39200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F3K22_RS39215	COG1131	(ABC) transporter
F3K22_RS39255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F3K22_RS39265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3K22_RS39270	COG4638	Rieske (2fe-2S)
F3K22_RS39280	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F3K22_RS39295	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS39300	COG0517	IMP dehydrogenase activity
F3K22_RS39300	COG4175	Glycine betaine
F3K22_RS39305	COG4176	ABC-type proline glycine betaine transport system permease component
F3K22_RS39320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F3K22_RS39340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F3K22_RS39370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3K22_RS39375	COG1760	l-serine dehydratase
F3K22_RS39380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F3K22_RS39390	COG4171	peptide transport system, permease
F3K22_RS39430	COG1703	isobutyryl-CoA mutase activity
F3K22_RS39430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS39430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3K22_RS39455	COG2308	Evidence 4 Homologs of previously reported genes of
F3K22_RS39455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F3K22_RS39460	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS39475	COG0583	DNA-binding transcription factor activity
F3K22_RS39480	COG0183	Belongs to the thiolase family
F3K22_RS39490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F3K22_RS39500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3K22_RS39515	COG0800	Aldolase
F3K22_RS39520	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS39525	COG1063	alcohol dehydrogenase
F3K22_RS39535	COG3618	amidohydrolase
F3K22_RS39540	COG4948	Mandelate Racemase Muconate Lactonizing
F3K22_RS39545	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3K22_RS39550	COG1129	ABC transporter
F3K22_RS39600	COG5640	endopeptidase activity
F3K22_RS39650	COG0596	Alpha beta hydrolase
F3K22_RS39655	COG2770	Histidine kinase
F3K22_RS39655	COG2208	phosphoserine phosphatase activity
F3K22_RS39660	COG1366	Belongs to the anti-sigma-factor antagonist family
F3K22_RS39705	COG2326	polyphosphate kinase activity
F3K22_RS39745	COG4585	Histidine kinase
F3K22_RS39750	COG2197	response regulator
F3K22_RS39760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3K22_RS39835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3K22_RS39840	COG0583	DNA-binding transcription factor activity
F3K22_RS39845	COG2851	Citrate transporter
F3K22_RS39865	COG1609	Transcriptional regulator
F3K22_RS39905	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS39950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3K22_RS39975	COG4585	Histidine kinase
F3K22_RS39980	COG2197	response regulator
F3K22_RS40005	COG2188	Transcriptional regulator
F3K22_RS40020	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F3K22_RS40040	COG0142	geranyltranstransferase activity
F3K22_RS40105	COG1609	Transcriptional regulator
F3K22_RS40115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3K22_RS40140	COG0601	transmembrane transport
F3K22_RS40145	COG4171	peptide transport system, permease
F3K22_RS40235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3K22_RS40275	COG5520	Belongs to the glycosyl hydrolase 30 family
F3K22_RS40280	COG1132	(ABC) transporter
F3K22_RS40285	COG2318	DinB family
F3K22_RS40305	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS40325	COG1136	(ABC) transporter
F3K22_RS40325	COG0577	efflux transmembrane transporter activity
F3K22_RS40330	COG1136	(ABC) transporter
F3K22_RS40330	COG0577	efflux transmembrane transporter activity
F3K22_RS40385	COG4977	sequence-specific DNA binding
F3K22_RS40405	COG5002	protein histidine kinase activity
F3K22_RS40410	COG2018	Roadblock/LC7 domain
F3K22_RS40475	COG1653	transport
F3K22_RS40515	COG2080	2 iron, 2 sulfur cluster binding
F3K22_RS40520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F3K22_RS40525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3K22_RS40540	COG1295	ribonuclease BN
F3K22_RS40565	COG1595	DNA-templated transcription, initiation
F3K22_RS40580	COG0702	epimerase
F3K22_RS40625	COG2326	polyphosphate kinase activity
F3K22_RS40630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F3K22_RS40635	COG1063	alcohol dehydrogenase
F3K22_RS40665	COG4191	Histidine kinase
F3K22_RS40710	COG0745	RESPONSE REGULATOR receiver
F3K22_RS40715	COG2205	protein histidine kinase activity
F3K22_RS40760	COG1252	NADH dehydrogenase
F3K22_RS40765	COG1595	DNA-templated transcription, initiation
F3K22_RS40780	COG3345	alpha-galactosidase
F3K22_RS40805	COG1012	belongs to the aldehyde dehydrogenase family
F3K22_RS40810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3K22_RS40890	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS40895	COG1132	(ABC) transporter
F3K22_RS40900	COG1132	(ABC) transporter
F3K22_RS40910	COG0515	serine threonine protein kinase
F3K22_RS40920	COG4249	Peptidase C14 caspase catalytic subunit p20
F3K22_RS40920	COG2319	Wd-40 repeat
F3K22_RS40925	COG0539	negative regulation of cytoplasmic translation
F3K22_RS40975	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
F3K22_RS40985	COG1621	beta-fructofuranosidase activity
F3K22_RS41010	COG0563	adenylate kinase activity
F3K22_RS41035	COG1733	regulation of RNA biosynthetic process
F3K22_RS41040	COG0667	Aldo Keto reductase
F3K22_RS41045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F3K22_RS41050	COG2175	clavaminate synthase activity
F3K22_RS41065	COG3320	Male sterility
F3K22_RS41065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3K22_RS41075	COG1960	acyl-CoA dehydrogenase activity
F3K22_RS41080	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS41095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3K22_RS41110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS41175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3K22_RS41190	COG0574	Belongs to the PEP-utilizing enzyme family
F3K22_RS41190	COG3848	Pyruvate phosphate dikinase
F3K22_RS41200	COG2814	Major facilitator Superfamily
F3K22_RS41270	COG4249	Peptidase C14 caspase catalytic subunit p20
F3K22_RS41270	COG2319	Wd-40 repeat
F3K22_RS41325	COG2197	response regulator
F3K22_RS41330	COG4585	Histidine kinase
F3K22_RS41335	COG1132	(ABC) transporter
F3K22_RS41360	COG2205	protein histidine kinase activity
F3K22_RS41365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F3K22_RS41370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F3K22_RS41375	COG0154	amidase activity
F3K22_RS41385	COG1309	transcriptional regulator
F3K22_RS41405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3K22_RS41440	COG0477	Major facilitator Superfamily
F3K22_RS41475	COG0590	tRNA wobble adenosine to inosine editing
F3K22_RS41480	COG3224	Antibiotic biosynthesis monooxygenase
F3K22_RS41505	COG0395	ABC-type sugar transport system, permease component
F3K22_RS41585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3K22_RS41595	COG1414	Transcriptional regulator
F3K22_RS41605	COG2146	nitrite reductase [NAD(P)H] activity
F3K22_RS41620	COG2267	carboxylic ester hydrolase activity
F3K22_RS41640	COG1028	Short-chain dehydrogenase reductase Sdr
F3K22_RS41640	COG0604	alcohol dehydrogenase
F3K22_RS41640	COG3321	synthase
F3K22_RS41650	COG3971	2-oxopent-4-enoate hydratase activity
F3K22_RS41655	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F3K22_RS41665	COG0477	Major facilitator Superfamily
F3K22_RS41675	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS41685	COG2223	nitrite transmembrane transporter activity
F3K22_RS41700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F3K22_RS41705	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F3K22_RS41715	COG0243	molybdopterin cofactor binding
F3K22_RS41720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3K22_RS41725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3K22_RS41725	COG2146	nitrite reductase [NAD(P)H] activity
F3K22_RS41830	COG1021	2,3-dihydroxybenzoate-AMP ligase
F3K22_RS41835	COG2197	response regulator
F3K22_RS41860	COG2070	2-Nitropropane dioxygenase
F3K22_RS41870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3K22_RS41880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3K22_RS41885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3K22_RS41890	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS41895	COG0318	PFAM AMP-dependent synthetase and ligase
F3K22_RS41905	COG2192	nodulation
F3K22_RS41920	COG3433	isochorismatase activity
F3K22_RS41920	COG2226	methyltransferase
F3K22_RS41920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS41925	COG2226	methyltransferase
F3K22_RS41925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3K22_RS41925	COG3433	isochorismatase activity
F3K22_RS41940	COG2375	cellular response to nickel ion
F3K22_RS41940	COG1132	(ABC) transporter
F3K22_RS41945	COG1132	(ABC) transporter
F3K22_RS41955	COG1021	2,3-dihydroxybenzoate-AMP ligase
F3K22_RS41975	COG3903	Transcriptional regulator
F3K22_RS41975	COG3629	intracellular signal transduction
F3K22_RS41990	COG2801	Transposase and inactivated derivatives
F3K22_RS42070	COG0483	inositol monophosphate 1-phosphatase activity
F3K22_RS42095	COG4585	Histidine kinase
F3K22_RS42100	COG2197	response regulator