locus-tag	class	description
H3V39_RS00005	COG0583	DNA-binding transcription factor activity
H3V39_RS00020	COG0590	tRNA wobble adenosine to inosine editing
H3V39_RS00035	COG0574	Belongs to the PEP-utilizing enzyme family
H3V39_RS00035	COG3848	Pyruvate phosphate dikinase
H3V39_RS00060	COG4977	sequence-specific DNA binding
H3V39_RS00080	COG4941	Belongs to the sigma-70 factor family
H3V39_RS00090	COG5297	Belongs to the glycosyl hydrolase family 6
H3V39_RS00125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3V39_RS00135	COG0477	Major facilitator Superfamily
H3V39_RS00145	COG1846	Transcriptional regulator
H3V39_RS00150	COG1764	response to oxidative stress
H3V39_RS00160	COG0789	Transcriptional regulator
H3V39_RS00185	COG1902	pentaerythritol trinitrate reductase activity
H3V39_RS00190	COG0640	Transcriptional regulator
H3V39_RS00195	COG1064	alcohol dehydrogenase
H3V39_RS00210	COG0702	epimerase
H3V39_RS00225	COG0642	Histidine kinase
H3V39_RS00240	COG2318	DinB family
H3V39_RS00295	COG1349	DNA-binding transcription factor activity
H3V39_RS00330	COG0596	Alpha beta hydrolase
H3V39_RS00360	COG2318	DinB family
H3V39_RS00385	COG0254	rRNA binding
H3V39_RS00390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3V39_RS00440	COG1024	Enoyl-CoA hydratase
H3V39_RS00460	COG1132	(ABC) transporter
H3V39_RS00465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H3V39_RS00480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H3V39_RS00510	COG2070	2-Nitropropane dioxygenase
H3V39_RS00515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H3V39_RS00525	COG0515	serine threonine protein kinase
H3V39_RS00530	COG0659	secondary active sulfate transmembrane transporter activity
H3V39_RS00535	COG0789	Transcriptional regulator
H3V39_RS00550	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS00555	COG2813	Specifically methylates the guanine in position
H3V39_RS00570	COG2356	endonuclease I
H3V39_RS00575	COG2066	Belongs to the glutaminase family
H3V39_RS00575	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H3V39_RS00585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H3V39_RS00590	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H3V39_RS00605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H3V39_RS00610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H3V39_RS00615	COG2080	2 iron, 2 sulfur cluster binding
H3V39_RS00660	COG2365	Tyrosine phosphatase family
H3V39_RS00695	COG1120	ATPase activity
H3V39_RS00700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3V39_RS00710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS00720	COG0477	Major facilitator Superfamily
H3V39_RS00730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS00740	COG1169	isochorismate synthase
H3V39_RS00745	COG1021	2,3-dihydroxybenzoate-AMP ligase
H3V39_RS00750	COG3433	isochorismatase activity
H3V39_RS00750	COG1535	isochorismatase
H3V39_RS00755	COG3433	isochorismatase activity
H3V39_RS00755	COG1535	isochorismatase
H3V39_RS00760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H3V39_RS00780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H3V39_RS00815	COG3845	ABC transporter
H3V39_RS00835	COG0148	phosphopyruvate hydratase activity
H3V39_RS00845	COG2382	esterase
H3V39_RS00850	COG1132	(ABC) transporter
H3V39_RS00865	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H3V39_RS00870	COG1120	ATPase activity
H3V39_RS00875	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS00880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS00885	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H3V39_RS00900	COG5002	protein histidine kinase activity
H3V39_RS00905	COG0745	RESPONSE REGULATOR receiver
H3V39_RS00935	COG3559	Exporter of polyketide antibiotics
H3V39_RS00950	COG0587	DNA-directed DNA polymerase activity
H3V39_RS01025	COG1295	ribonuclease BN
H3V39_RS01050	COG4221	oxidoreductase activity
H3V39_RS01055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS01090	COG1120	ATPase activity
H3V39_RS01095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS01110	COG1132	(ABC) transporter
H3V39_RS01150	COG4934	collagen metabolic process
H3V39_RS01190	COG1404	Belongs to the peptidase S8 family
H3V39_RS01200	COG1672	PFAM Archaeal ATPase
H3V39_RS01200	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H3V39_RS01265	COG2376	Dihydroxyacetone kinase
H3V39_RS01270	COG1461	Dihydroxyacetone kinase
H3V39_RS01285	COG0488	(ABC) transporter
H3V39_RS01315	COG1191	sigma factor activity
H3V39_RS01320	COG1309	transcriptional regulator
H3V39_RS01325	COG3246	L-lysine catabolic process to acetate
H3V39_RS01330	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS01345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H3V39_RS01350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H3V39_RS01365	COG1120	ATPase activity
H3V39_RS01370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS01395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS01480	COG1120	ATPase activity
H3V39_RS01485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS01490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS01500	COG0789	Transcriptional regulator
H3V39_RS01525	COG0366	Alpha amylase catalytic
H3V39_RS01525	COG1874	Beta-galactosidase
H3V39_RS01535	COG1172	Belongs to the binding-protein-dependent transport system permease family
H3V39_RS01545	COG1129	ABC transporter
H3V39_RS01550	COG1879	ABC-type sugar transport system periplasmic component
H3V39_RS01605	COG0328	RNA-DNA hybrid ribonuclease activity
H3V39_RS01610	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS01615	COG1132	(ABC) transporter
H3V39_RS01640	COG2207	Transcriptional regulator
H3V39_RS01640	COG4753	response regulator
H3V39_RS01645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS01650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS01655	COG1120	ATPase activity
H3V39_RS01665	COG2274	protein secretion by the type I secretion system
H3V39_RS01670	COG1132	(ABC) transporter
H3V39_RS01780	COG5002	protein histidine kinase activity
H3V39_RS01815	COG0464	growth
H3V39_RS01825	COG1349	DNA-binding transcription factor activity
H3V39_RS01840	COG0702	epimerase
H3V39_RS01875	COG1940	carbohydrate kinase activity
H3V39_RS01880	COG2223	nitrite transmembrane transporter activity
H3V39_RS01900	COG0445	tRNA wobble uridine modification
H3V39_RS01910	COG0494	nUDIX hydrolase
H3V39_RS01940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H3V39_RS01990	COG0584	glycerophosphoryl diester phosphodiesterase
H3V39_RS02010	COG0671	phosphoesterase, PA-phosphatase related
H3V39_RS02055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H3V39_RS02070	COG2706	6-phosphogluconolactonase activity
H3V39_RS02115	COG3961	Belongs to the TPP enzyme family
H3V39_RS02120	COG2197	response regulator
H3V39_RS02135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H3V39_RS02140	COG3483	tryptophan 2,3-dioxygenase activity
H3V39_RS02145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H3V39_RS02165	COG0107	imidazoleglycerol-phosphate synthase activity
H3V39_RS02170	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H3V39_RS02220	COG0515	serine threonine protein kinase
H3V39_RS02220	COG2815	serine threonine protein kinase
H3V39_RS02225	COG0667	Aldo Keto reductase
H3V39_RS02250	COG1253	flavin adenine dinucleotide binding
H3V39_RS02285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H3V39_RS02290	COG0531	amino acid
H3V39_RS02300	COG0174	glutamine synthetase
H3V39_RS02305	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS02340	COG4981	capsule polysaccharide biosynthetic process
H3V39_RS02360	COG2835	tetraacyldisaccharide 4'-kinase activity
H3V39_RS02370	COG1802	Transcriptional regulator
H3V39_RS02375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3V39_RS02380	COG0402	S-adenosylhomocysteine deaminase activity
H3V39_RS02395	COG0243	molybdopterin cofactor binding
H3V39_RS02400	COG0542	response to heat
H3V39_RS02465	COG2890	protein-(glutamine-N5) methyltransferase activity
H3V39_RS02475	COG4912	Dna alkylation repair
H3V39_RS02495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H3V39_RS02500	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H3V39_RS02505	COG2080	2 iron, 2 sulfur cluster binding
H3V39_RS02535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3V39_RS02545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS02600	COG1891	lyase activity
H3V39_RS02615	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H3V39_RS02675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H3V39_RS02700	COG1309	transcriptional regulator
H3V39_RS02710	COG1309	transcriptional regulator
H3V39_RS02715	COG0154	amidase activity
H3V39_RS02725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS02730	COG2814	Major facilitator Superfamily
H3V39_RS02760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3V39_RS02765	COG1116	anion transmembrane transporter activity
H3V39_RS02780	COG2072	flavoprotein involved in K transport
H3V39_RS02785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H3V39_RS02795	COG1132	(ABC) transporter
H3V39_RS02800	COG1846	Transcriptional regulator
H3V39_RS02805	COG0277	FAD linked oxidase domain protein
H3V39_RS02810	COG0673	inositol 2-dehydrogenase activity
H3V39_RS02815	COG1132	(ABC) transporter
H3V39_RS02820	COG1132	(ABC) transporter
H3V39_RS02840	COG1793	dna ligase
H3V39_RS02855	COG1946	Acyl-CoA thioesterase
H3V39_RS02870	COG0386	Belongs to the glutathione peroxidase family
H3V39_RS02875	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS02885	COG0242	peptide deformylase activity
H3V39_RS02895	COG3442	glutamine amidotransferase
H3V39_RS02900	COG0205	6-phosphofructokinase activity
H3V39_RS02915	COG0204	Acyl-transferase
H3V39_RS02930	COG0829	nickel cation binding
H3V39_RS02935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H3V39_RS02945	COG0804	urea catabolic process
H3V39_RS02950	COG0832	Belongs to the urease beta subunit family
H3V39_RS02955	COG0831	urea catabolic process
H3V39_RS02960	COG1309	transcriptional regulator
H3V39_RS02975	COG0740	serine-type endopeptidase activity
H3V39_RS02990	COG1280	lysine exporter protein (LysE YggA)
H3V39_RS02995	COG0583	DNA-binding transcription factor activity
H3V39_RS03015	COG0156	8-amino-7-oxononanoate synthase activity
H3V39_RS03020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H3V39_RS03025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H3V39_RS03030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H3V39_RS03035	COG2226	methyltransferase
H3V39_RS03075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H3V39_RS03085	COG1940	carbohydrate kinase activity
H3V39_RS03090	COG2188	Transcriptional regulator
H3V39_RS03095	COG1595	DNA-templated transcription, initiation
H3V39_RS03110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H3V39_RS03135	COG0626	cystathionine gamma-synthase activity
H3V39_RS03155	COG0419	ATPase involved in DNA repair
H3V39_RS03160	COG0420	3'-5' exonuclease activity
H3V39_RS03165	COG1739	Uncharacterized protein family UPF0029
H3V39_RS03170	COG1832	CoA-binding protein
H3V39_RS03210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H3V39_RS03230	COG1968	undecaprenyl-diphosphatase activity
H3V39_RS03250	COG0243	molybdopterin cofactor binding
H3V39_RS03255	COG2226	methyltransferase
H3V39_RS03320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H3V39_RS03380	COG0069	glutamate synthase activity
H3V39_RS03425	COG0784	Response regulator, receiver
H3V39_RS03430	COG4251	negative regulation of phosphorylation
H3V39_RS03435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H3V39_RS03445	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H3V39_RS03455	COG1215	transferase activity, transferring glycosyl groups
H3V39_RS03475	COG3800	Transcriptional regulator
H3V39_RS03475	COG1396	sequence-specific DNA binding
H3V39_RS03575	COG1695	Transcriptional regulator
H3V39_RS03600	COG1595	DNA-templated transcription, initiation
H3V39_RS03655	COG0384	phenazine biosynthesis protein PhzF
H3V39_RS03685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H3V39_RS03685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H3V39_RS03695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H3V39_RS03715	COG1716	ATPase activity
H3V39_RS03735	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H3V39_RS03765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3V39_RS03775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3V39_RS03790	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H3V39_RS03820	COG2018	Roadblock/LC7 domain
H3V39_RS03885	COG2364	Membrane
H3V39_RS03895	COG2270	Major facilitator Superfamily
H3V39_RS03910	COG1216	Glycosyl transferase, family 2
H3V39_RS03930	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS03935	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS03945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H3V39_RS03955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H3V39_RS03990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H3V39_RS03995	COG0140	phosphoribosyl-ATP diphosphatase activity
H3V39_RS04000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H3V39_RS04005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3V39_RS04005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3V39_RS04010	COG3201	nicotinamide mononucleotide transporter
H3V39_RS04035	COG0738	Major facilitator superfamily
H3V39_RS04040	COG2233	PERMEase
H3V39_RS04050	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS04065	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H3V39_RS04085	COG0142	geranyltranstransferase activity
H3V39_RS04100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H3V39_RS04110	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS04125	COG2390	Transcriptional regulator
H3V39_RS04130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H3V39_RS04140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H3V39_RS04155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H3V39_RS04165	COG1758	RNA polymerase activity
H3V39_RS04180	COG0284	orotidine-5'-phosphate decarboxylase activity
H3V39_RS04185	COG0167	dihydroorotate dehydrogenase activity
H3V39_RS04190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3V39_RS04195	COG0505	Belongs to the CarA family
H3V39_RS04205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3V39_RS04210	COG0540	Belongs to the ATCase OTCase family
H3V39_RS04215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H3V39_RS04225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H3V39_RS04230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H3V39_RS04235	COG0006	proline dipeptidase activity
H3V39_RS04245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H3V39_RS04250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H3V39_RS04255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H3V39_RS04260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H3V39_RS04270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H3V39_RS04275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H3V39_RS04295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H3V39_RS04315	COG0124	histidyl-tRNA synthetase
H3V39_RS04330	COG1196	nuclear chromosome segregation
H3V39_RS04350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3V39_RS04355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H3V39_RS04360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3V39_RS04365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3V39_RS04375	COG2255	four-way junction helicase activity
H3V39_RS04380	COG0632	four-way junction helicase activity
H3V39_RS04390	COG0217	transcriptional regulatory protein
H3V39_RS04395	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H3V39_RS04400	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H3V39_RS04410	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS04415	COG1560	Kdo2-lipid A biosynthetic process
H3V39_RS04420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H3V39_RS04440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H3V39_RS04455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H3V39_RS04515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H3V39_RS04570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H3V39_RS04570	COG1648	precorrin-2 dehydrogenase activity
H3V39_RS04575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H3V39_RS04590	COG1464	Belongs to the NlpA lipoprotein family
H3V39_RS04595	COG2011	ABC-type metal ion transport system permease component
H3V39_RS04635	COG0477	Major facilitator Superfamily
H3V39_RS04645	COG3973	AAA domain
H3V39_RS04655	COG0165	Argininosuccinate lyase
H3V39_RS04660	COG0137	argininosuccinate synthase activity
H3V39_RS04675	COG1438	arginine binding
H3V39_RS04680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3V39_RS04685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H3V39_RS04690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H3V39_RS04695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H3V39_RS04755	COG0697	spore germination
H3V39_RS04765	COG1649	PFAM Uncharacterised BCR, COG1649
H3V39_RS04790	COG0072	phenylalanine-tRNA ligase activity
H3V39_RS04790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3V39_RS04795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H3V39_RS04800	COG5002	protein histidine kinase activity
H3V39_RS04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3V39_RS04810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H3V39_RS04815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H3V39_RS04820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H3V39_RS04830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3V39_RS04885	COG0517	IMP dehydrogenase activity
H3V39_RS04885	COG4175	Glycine betaine
H3V39_RS04890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3V39_RS04920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H3V39_RS04925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H3V39_RS04965	COG0805	protein transport
H3V39_RS04970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H3V39_RS04990	COG2378	regulation of single-species biofilm formation
H3V39_RS05000	COG0545	Peptidyl-prolyl cis-trans isomerase
H3V39_RS05005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H3V39_RS05015	COG1609	Transcriptional regulator
H3V39_RS05020	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H3V39_RS05025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H3V39_RS05035	COG4122	O-methyltransferase activity
H3V39_RS05040	COG1222	aaa ATPase
H3V39_RS05060	COG1994	Peptidase M50
H3V39_RS05060	COG0517	IMP dehydrogenase activity
H3V39_RS05070	COG2197	response regulator
H3V39_RS05075	COG4166	transmembrane transport
H3V39_RS05080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS05085	COG1410	methionine synthase
H3V39_RS05085	COG0646	methionine synthase
H3V39_RS05090	COG1414	Transcriptional regulator
H3V39_RS05095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3V39_RS05100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3V39_RS05105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H3V39_RS05110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS05120	COG0215	cysteine-tRNA ligase activity
H3V39_RS05140	COG0598	Magnesium transport protein CorA
H3V39_RS05150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS05155	COG0667	Aldo Keto reductase
H3V39_RS05185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3V39_RS05195	COG0564	pseudouridine synthase activity
H3V39_RS05210	COG2186	Transcriptional regulator
H3V39_RS05215	COG3265	gluconokinase activity
H3V39_RS05240	COG3573	Dehydrogenase
H3V39_RS05245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H3V39_RS05250	COG2149	membrane
H3V39_RS05270	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS05275	COG2234	aminopeptidase activity
H3V39_RS05275	COG4935	Belongs to the peptidase S8 family
H3V39_RS05285	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS05295	COG3876	Protein conserved in bacteria
H3V39_RS05330	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS05345	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H3V39_RS05355	COG2318	DinB family
H3V39_RS05365	COG2851	Citrate transporter
H3V39_RS05370	COG1309	transcriptional regulator
H3V39_RS05390	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H3V39_RS05395	COG2188	Transcriptional regulator
H3V39_RS05405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3V39_RS05415	COG2755	lipolytic protein G-D-S-L family
H3V39_RS05425	COG1725	Transcriptional regulator
H3V39_RS05440	COG0346	lactoylglutathione lyase activity
H3V39_RS05460	COG4565	transcriptional regulatory protein
H3V39_RS05495	COG4585	Histidine kinase
H3V39_RS05500	COG2197	response regulator
H3V39_RS05510	COG1192	Involved in chromosome partitioning
H3V39_RS05520	COG0641	radical SAM
H3V39_RS05555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS05560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS05565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3V39_RS05570	COG1126	abc transporter atp-binding protein
H3V39_RS05585	COG0765	amino acid transport
H3V39_RS05590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3V39_RS05600	COG1799	cell septum assembly
H3V39_RS05605	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS05610	COG0477	Major facilitator Superfamily
H3V39_RS05615	COG0671	phosphoesterase, PA-phosphatase related
H3V39_RS05630	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS05645	COG1160	GTP binding
H3V39_RS05655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H3V39_RS05680	COG0494	nUDIX hydrolase
H3V39_RS05695	COG1187	pseudouridine synthase activity
H3V39_RS05700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H3V39_RS05705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H3V39_RS05720	COG0686	Belongs to the AlaDH PNT family
H3V39_RS05730	COG0494	nUDIX hydrolase
H3V39_RS05735	COG0504	CTP synthase activity
H3V39_RS05740	COG3387	PFAM Glycoside hydrolase 15-related
H3V39_RS05765	COG0497	DNA recombination
H3V39_RS05770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H3V39_RS05790	COG1120	ATPase activity
H3V39_RS05795	COG0647	UMP catabolic process
H3V39_RS05830	COG2094	Belongs to the DNA glycosylase MPG family
H3V39_RS05840	COG1881	PFAM PEBP family protein
H3V39_RS05865	COG1119	ATPase activity
H3V39_RS05875	COG2197	response regulator
H3V39_RS05880	COG4585	Histidine kinase
H3V39_RS05890	COG0842	Transport permease protein
H3V39_RS05890	COG1131	(ABC) transporter
H3V39_RS05890	COG1716	ATPase activity
H3V39_RS05895	COG0560	Phosphoserine phosphatase
H3V39_RS05895	COG3830	Belongs to the UPF0237 family
H3V39_RS05925	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H3V39_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS05955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H3V39_RS05960	COG2261	transglycosylase associated protein
H3V39_RS05975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H3V39_RS05980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3V39_RS06020	COG3387	PFAM Glycoside hydrolase 15-related
H3V39_RS06060	COG1024	Enoyl-CoA hydratase
H3V39_RS06070	COG0488	(ABC) transporter
H3V39_RS06095	COG0235	Class ii aldolase
H3V39_RS06110	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H3V39_RS06115	COG1492	cobalamin metabolic process
H3V39_RS06130	COG1797	cobyrinic acid a,c-diamide synthase activity
H3V39_RS06160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H3V39_RS06190	COG1902	pentaerythritol trinitrate reductase activity
H3V39_RS06240	COG4585	Histidine kinase
H3V39_RS06245	COG2197	response regulator
H3V39_RS06250	COG0768	penicillin binding
H3V39_RS06290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3V39_RS06295	COG2171	N-acyltransferase activity
H3V39_RS06305	COG3226	Transcriptional regulator
H3V39_RS06320	COG2151	metal-sulfur cluster biosynthetic enzyme
H3V39_RS06325	COG0822	iron-sulfur transferase activity
H3V39_RS06330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H3V39_RS06335	COG0396	ATPase activity
H3V39_RS06345	COG0719	Fe-S assembly protein
H3V39_RS06380	COG0109	protoheme IX farnesyltransferase activity
H3V39_RS06390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H3V39_RS06405	COG0363	glucosamine-6-phosphate deaminase activity
H3V39_RS06415	COG4195	phage-related replication protein
H3V39_RS06430	COG0166	Belongs to the GPI family
H3V39_RS06440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H3V39_RS06445	COG0149	triose-phosphate isomerase activity
H3V39_RS06450	COG0126	phosphoglycerate kinase activity
H3V39_RS06455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H3V39_RS06460	COG1481	regulation of sporulation
H3V39_RS06465	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H3V39_RS06470	COG1660	Displays ATPase and GTPase activities
H3V39_RS06475	COG0322	excinuclease ABC activity
H3V39_RS06500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3V39_RS06530	COG0556	nucleotide-excision repair
H3V39_RS06540	COG0584	glycerophosphoryl diester phosphodiesterase
H3V39_RS06550	COG2814	Major facilitator Superfamily
H3V39_RS06560	COG2313	pseudouridylate synthase activity
H3V39_RS06580	COG0436	Aminotransferase
H3V39_RS06600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H3V39_RS06610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H3V39_RS06630	COG0237	dephospho-CoA kinase activity
H3V39_RS06650	COG2226	methyltransferase
H3V39_RS06655	COG1643	Atp-dependent helicase
H3V39_RS06690	COG2050	protein possibly involved in aromatic compounds catabolism
H3V39_RS06700	COG0559	Belongs to the binding-protein-dependent transport system permease family
H3V39_RS06745	COG0737	Belongs to the 5'-nucleotidase family
H3V39_RS06780	COG1605	Chorismate mutase
H3V39_RS06780	COG0287	Prephenate dehydrogenase
H3V39_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS06820	COG1024	Enoyl-CoA hydratase
H3V39_RS06845	COG1278	Cold shock
H3V39_RS06850	COG0183	Belongs to the thiolase family
H3V39_RS06855	COG1309	transcriptional regulator
H3V39_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS06865	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS06890	COG0705	Rhomboid family
H3V39_RS06900	COG0067	glutamate synthase
H3V39_RS06900	COG0069	glutamate synthase activity
H3V39_RS06900	COG0070	glutamate synthase
H3V39_RS06930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3V39_RS06935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3V39_RS06945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H3V39_RS06955	COG0159	tryptophan synthase activity
H3V39_RS06960	COG0133	tryptophan synthase activity
H3V39_RS06970	COG0134	indole-3-glycerol-phosphate synthase activity
H3V39_RS06990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H3V39_RS06995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H3V39_RS07015	COG0107	imidazoleglycerol-phosphate synthase activity
H3V39_RS07020	COG0251	oxidation-reduction process
H3V39_RS07025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H3V39_RS07030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H3V39_RS07040	COG0131	Imidazoleglycerol-phosphate dehydratase
H3V39_RS07045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H3V39_RS07050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H3V39_RS07070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H3V39_RS07090	COG1432	Conserved Protein
H3V39_RS07100	COG0587	DNA-directed DNA polymerase activity
H3V39_RS07145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H3V39_RS07155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H3V39_RS07160	COG3599	regulation of cell shape
H3V39_RS07170	COG1799	cell septum assembly
H3V39_RS07175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H3V39_RS07195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H3V39_RS07205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H3V39_RS07210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H3V39_RS07220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H3V39_RS07225	COG0768	penicillin binding
H3V39_RS07235	COG0275	rRNA processing
H3V39_RS07245	COG0714	Associated with various cellular activities
H3V39_RS07265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H3V39_RS07275	COG0577	efflux transmembrane transporter activity
H3V39_RS07275	COG1136	(ABC) transporter
H3V39_RS07295	COG1233	COG1233 Phytoene dehydrogenase and related
H3V39_RS07310	COG0352	thiamine-phosphate diphosphorylase activity
H3V39_RS07330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3V39_RS07330	COG2022	thiamine diphosphate biosynthetic process
H3V39_RS07340	COG2022	thiamine diphosphate biosynthetic process
H3V39_RS07345	COG0515	serine threonine protein kinase
H3V39_RS07345	COG2815	serine threonine protein kinase
H3V39_RS07350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H3V39_RS07355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H3V39_RS07360	COG2193	ferroxidase activity
H3V39_RS07370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H3V39_RS07385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3V39_RS07390	COG2197	response regulator
H3V39_RS07420	COG1940	carbohydrate kinase activity
H3V39_RS07430	COG0003	Pfam Anion-transporting ATPase
H3V39_RS07495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H3V39_RS07500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H3V39_RS07505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H3V39_RS07510	COG0723	plastoquinol--plastocyanin reductase activity
H3V39_RS07515	COG2010	Cytochrome c
H3V39_RS07520	COG1845	cytochrome c oxidase, subunit III
H3V39_RS07530	COG1376	ErfK ybiS ycfS ynhG family protein
H3V39_RS07540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H3V39_RS07545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H3V39_RS07555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3V39_RS07575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H3V39_RS07585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H3V39_RS07590	COG2197	response regulator
H3V39_RS07595	COG4585	Histidine kinase
H3V39_RS07620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3V39_RS07650	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H3V39_RS07655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H3V39_RS07660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3V39_RS07665	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3V39_RS07675	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H3V39_RS07695	COG1090	epimerase
H3V39_RS07710	COG0321	lipoyl(octanoyl) transferase activity
H3V39_RS07715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H3V39_RS07740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H3V39_RS07745	COG3896	Chloramphenicol phosphotransferase-like protein
H3V39_RS07770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H3V39_RS07775	COG0673	inositol 2-dehydrogenase activity
H3V39_RS07795	COG0745	RESPONSE REGULATOR receiver
H3V39_RS07800	COG2409	Drug exporters of the RND superfamily
H3V39_RS07805	COG4585	Histidine kinase
H3V39_RS07810	COG2197	response regulator
H3V39_RS07870	COG0366	Alpha amylase catalytic
H3V39_RS07875	COG0395	ABC-type sugar transport system, permease component
H3V39_RS07885	COG2182	Extracellular solute-binding protein
H3V39_RS07890	COG1609	Transcriptional regulator
H3V39_RS07900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H3V39_RS07905	COG2890	protein-(glutamine-N5) methyltransferase activity
H3V39_RS07910	COG0477	Major facilitator Superfamily
H3V39_RS07950	COG0494	nUDIX hydrolase
H3V39_RS07980	COG0174	glutamine synthetase
H3V39_RS07995	COG2132	Multicopper oxidase
H3V39_RS08000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H3V39_RS08000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H3V39_RS08005	COG2814	Major facilitator Superfamily
H3V39_RS08020	COG0477	Major facilitator Superfamily
H3V39_RS08025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H3V39_RS08045	COG1994	Peptidase M50
H3V39_RS08105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS08110	COG1120	ATPase activity
H3V39_RS08130	COG1834	amidinotransferase
H3V39_RS08145	COG2814	Major facilitator Superfamily
H3V39_RS08155	COG3540	Alkaline phosphatase
H3V39_RS08160	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS08170	COG0384	phenazine biosynthesis protein PhzF
H3V39_RS08210	COG2273	Hydrolase Family 16
H3V39_RS08235	COG3022	response to hydroperoxide
H3V39_RS08240	COG0800	Aldolase
H3V39_RS08255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H3V39_RS08260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3V39_RS08275	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS08285	COG2030	dehydratase
H3V39_RS08295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H3V39_RS08300	COG0183	Belongs to the thiolase family
H3V39_RS08305	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS08315	COG3340	Belongs to the peptidase S51 family
H3V39_RS08330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H3V39_RS08335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3V39_RS08355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS08380	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS08385	COG1309	transcriptional regulator
H3V39_RS08420	COG3845	ABC transporter
H3V39_RS08430	COG0183	Belongs to the thiolase family
H3V39_RS08480	COG2259	Doxx family
H3V39_RS08545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H3V39_RS08580	COG1358	cellular component organization or biogenesis
H3V39_RS08625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H3V39_RS08635	COG0477	Major facilitator Superfamily
H3V39_RS08640	COG1309	transcriptional regulator
H3V39_RS08655	COG4585	Histidine kinase
H3V39_RS08660	COG2197	response regulator
H3V39_RS08675	COG0667	Aldo Keto reductase
H3V39_RS08680	COG0789	Transcriptional regulator
H3V39_RS08690	COG2205	protein histidine kinase activity
H3V39_RS08695	COG0745	RESPONSE REGULATOR receiver
H3V39_RS08705	COG0667	Aldo Keto reductase
H3V39_RS08715	COG1929	Belongs to the glycerate kinase type-1 family
H3V39_RS08790	COG1674	ftsk spoiiie
H3V39_RS08795	COG1404	Belongs to the peptidase S8 family
H3V39_RS08845	COG2957	Belongs to the agmatine deiminase family
H3V39_RS08850	COG0456	acetyltransferase
H3V39_RS08860	COG1741	Belongs to the pirin family
H3V39_RS08905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3V39_RS08910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS08915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS08940	COG1280	lysine exporter protein (LysE YggA)
H3V39_RS08950	COG1764	response to oxidative stress
H3V39_RS08955	COG2130	NADP-dependent
H3V39_RS08985	COG1522	sequence-specific DNA binding
H3V39_RS08995	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS09000	COG0825	malonyl-CoA metabolic process
H3V39_RS09000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3V39_RS09030	COG1070	Carbohydrate kinase
H3V39_RS09045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3V39_RS09050	COG0358	DNA primase activity
H3V39_RS09060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H3V39_RS09070	COG2949	membrane
H3V39_RS09115	COG2146	nitrite reductase [NAD(P)H] activity
H3V39_RS09115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H3V39_RS09140	COG0574	Belongs to the PEP-utilizing enzyme family
H3V39_RS09140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3V39_RS09145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS09150	COG3842	ATPase activity
H3V39_RS09170	COG2188	Transcriptional regulator
H3V39_RS09210	COG0477	Major facilitator Superfamily
H3V39_RS09215	COG2066	Belongs to the glutaminase family
H3V39_RS09230	COG1309	transcriptional regulator
H3V39_RS09240	COG1309	transcriptional regulator
H3V39_RS09360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3V39_RS09375	COG0277	FAD linked oxidase domain protein
H3V39_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS09385	COG2124	cytochrome p450
H3V39_RS09420	COG0477	Major facilitator Superfamily
H3V39_RS09425	COG2345	Transcriptional regulator
H3V39_RS09450	COG0367	asparagine synthase
H3V39_RS09460	COG0662	Cupin 2, conserved barrel domain protein
H3V39_RS09465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS09470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS09495	COG3104	oligopeptide transport
H3V39_RS09505	COG0423	glycine-tRNA ligase activity
H3V39_RS09515	COG1121	(ABC) transporter
H3V39_RS09520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3V39_RS09530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3V39_RS09535	COG1381	Involved in DNA repair and RecF pathway recombination
H3V39_RS09545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H3V39_RS09560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H3V39_RS09580	COG2315	Protein conserved in bacteria
H3V39_RS09590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H3V39_RS09600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H3V39_RS09600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H3V39_RS09610	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3V39_RS09615	COG1234	tRNA 3'-trailer cleavage
H3V39_RS09620	COG0537	adenosine 5'-monophosphoramidase activity
H3V39_RS09635	COG0484	heat shock protein binding
H3V39_RS09640	COG1420	regulation of RNA biosynthetic process
H3V39_RS09675	COG1022	Amp-dependent synthetase and ligase
H3V39_RS09680	COG0481	GTPase activity
H3V39_RS09685	COG0268	Binds directly to 16S ribosomal RNA
H3V39_RS09715	COG1555	photosystem II stabilization
H3V39_RS09720	COG1307	EDD domain protein, DegV family
H3V39_RS09730	COG0495	leucyl-tRNA aminoacylation
H3V39_RS09750	COG0588	phosphoglycerate mutase activity
H3V39_RS09755	COG0799	negative regulation of ribosome biogenesis
H3V39_RS09765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H3V39_RS09780	COG0501	Belongs to the peptidase M48B family
H3V39_RS09795	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H3V39_RS09805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H3V39_RS09830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H3V39_RS09835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H3V39_RS09840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H3V39_RS09845	COG1530	ribonuclease E activity
H3V39_RS09870	COG0772	Belongs to the SEDS family
H3V39_RS09875	COG0768	penicillin binding
H3V39_RS09890	COG1077	Cell shape determining protein MreB Mrl
H3V39_RS09895	COG0105	UTP biosynthetic process
H3V39_RS09905	COG0285	dihydrofolate synthase activity
H3V39_RS09910	COG0525	valine-tRNA ligase activity
H3V39_RS09920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H3V39_RS09925	COG0740	serine-type endopeptidase activity
H3V39_RS09930	COG0740	serine-type endopeptidase activity
H3V39_RS09935	COG0544	peptidyl-prolyl cis-trans isomerase activity
H3V39_RS09955	COG3594	Acyltransferase
H3V39_RS09965	COG0475	glutathione-regulated potassium exporter activity
H3V39_RS09985	COG1113	amino acid transport
H3V39_RS09995	COG1268	BioY protein
H3V39_RS10000	COG1113	amino acid transport
H3V39_RS10005	COG1113	amino acid transport
H3V39_RS10010	COG0584	glycerophosphoryl diester phosphodiesterase
H3V39_RS10015	COG0783	Belongs to the Dps family
H3V39_RS10025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H3V39_RS10030	COG0640	Transcriptional regulator
H3V39_RS10045	COG0110	maltose O-acetyltransferase activity
H3V39_RS10065	COG2252	PERMEase
H3V39_RS10075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H3V39_RS10120	COG4266	Belongs to the allantoicase family
H3V39_RS10125	COG0583	DNA-binding transcription factor activity
H3V39_RS10145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H3V39_RS10145	COG3291	Pkd domain containing protein
H3V39_RS10155	COG0668	transmembrane transport
H3V39_RS10185	COG1175	transmembrane transport
H3V39_RS10190	COG0395	ABC-type sugar transport system, permease component
H3V39_RS10195	COG1486	melibiose metabolic process
H3V39_RS10210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3V39_RS10240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H3V39_RS10245	COG2346	COG2346, Truncated hemoglobins
H3V39_RS10260	COG0577	efflux transmembrane transporter activity
H3V39_RS10260	COG1136	(ABC) transporter
H3V39_RS10285	COG0629	single-stranded DNA binding
H3V39_RS10360	COG4585	Histidine kinase
H3V39_RS10380	COG3962	Belongs to the TPP enzyme family
H3V39_RS10385	COG3718	enzyme involved in inositol metabolism
H3V39_RS10395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3V39_RS10405	COG2318	DinB family
H3V39_RS10420	COG2409	Drug exporters of the RND superfamily
H3V39_RS10445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3V39_RS10465	COG0596	Alpha beta hydrolase
H3V39_RS10510	COG0673	inositol 2-dehydrogenase activity
H3V39_RS10515	COG1609	Transcriptional regulator
H3V39_RS10580	COG1672	PFAM Archaeal ATPase
H3V39_RS10580	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H3V39_RS10585	COG1404	Belongs to the peptidase S8 family
H3V39_RS10610	COG1472	Belongs to the glycosyl hydrolase 3 family
H3V39_RS10625	COG0477	Major facilitator Superfamily
H3V39_RS10655	COG0028	Belongs to the TPP enzyme family
H3V39_RS10690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3V39_RS10715	COG1946	Acyl-CoA thioesterase
H3V39_RS10745	COG1309	transcriptional regulator
H3V39_RS10750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3V39_RS10765	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS10785	COG0076	glutamate decarboxylase activity
H3V39_RS10790	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H3V39_RS10815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3V39_RS10825	COG4977	sequence-specific DNA binding
H3V39_RS10860	COG0395	ABC-type sugar transport system, permease component
H3V39_RS10875	COG2985	domain, Protein
H3V39_RS10890	COG0745	RESPONSE REGULATOR receiver
H3V39_RS10965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS10975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H3V39_RS10985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3V39_RS10990	COG0765	amino acid transport
H3V39_RS10995	COG0765	amino acid transport
H3V39_RS11000	COG1126	abc transporter atp-binding protein
H3V39_RS11005	COG1414	Transcriptional regulator
H3V39_RS11015	COG3397	chitin binding
H3V39_RS11080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3V39_RS11085	COG2188	Transcriptional regulator
H3V39_RS11095	COG1940	carbohydrate kinase activity
H3V39_RS11100	COG0673	inositol 2-dehydrogenase activity
H3V39_RS11105	COG4702	Belongs to the UPF0303 family
H3V39_RS11110	COG0179	Fumarylacetoacetate (FAA) hydrolase
H3V39_RS11115	COG0706	membrane insertase activity
H3V39_RS11115	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
H3V39_RS11125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3V39_RS11135	COG3764	Sortase (surface protein transpeptidase)
H3V39_RS11180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H3V39_RS11195	COG2175	clavaminate synthase activity
H3V39_RS11205	COG0596	Alpha beta hydrolase
H3V39_RS11215	COG2733	membrane
H3V39_RS11230	COG4555	ABC transporter
H3V39_RS11245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3V39_RS11270	COG0477	Major facilitator Superfamily
H3V39_RS11290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H3V39_RS11300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H3V39_RS11305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3V39_RS11310	COG1263	PTS System
H3V39_RS11315	COG1263	PTS System
H3V39_RS11325	COG1234	tRNA 3'-trailer cleavage
H3V39_RS11345	COG1120	ATPase activity
H3V39_RS11350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS11365	COG1113	amino acid transport
H3V39_RS11375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H3V39_RS11385	COG1335	isochorismatase
H3V39_RS11420	COG0277	FAD linked oxidase domain protein
H3V39_RS11430	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H3V39_RS11440	COG1174	glycine betaine transport
H3V39_RS11445	COG0517	IMP dehydrogenase activity
H3V39_RS11445	COG1125	glycine betaine transport
H3V39_RS11450	COG1174	glycine betaine transport
H3V39_RS11455	COG1732	Glycine betaine
H3V39_RS11475	COG3480	Lon protease (S16) C-terminal proteolytic domain
H3V39_RS11505	COG3654	unkown
H3V39_RS11550	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H3V39_RS11555	COG0395	ABC-type sugar transport system, permease component
H3V39_RS11565	COG2182	Extracellular solute-binding protein
H3V39_RS11575	COG1678	Uncharacterized ACR, COG1678
H3V39_RS11580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H3V39_RS11585	COG0776	regulation of translation
H3V39_RS11595	COG3973	AAA domain
H3V39_RS11595	COG3973	AAA domain
H3V39_RS11620	COG2223	nitrite transmembrane transporter activity
H3V39_RS11625	COG0583	DNA-binding transcription factor activity
H3V39_RS11670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H3V39_RS11675	COG0793	Belongs to the peptidase S41A family
H3V39_RS11680	COG2177	Part of the ABC transporter FtsEX involved in
H3V39_RS11685	COG2884	Cell division ATP-binding protein ftsE
H3V39_RS11700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H3V39_RS11705	COG0515	serine threonine protein kinase
H3V39_RS11710	COG0515	serine threonine protein kinase
H3V39_RS11720	COG1653	transport
H3V39_RS11725	COG1175	transmembrane transport
H3V39_RS11730	COG0395	ABC-type sugar transport system, permease component
H3V39_RS11735	COG1442	glycosyl transferase family 8
H3V39_RS11735	COG1216	Glycosyl transferase, family 2
H3V39_RS11740	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS11750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H3V39_RS11755	COG4122	O-methyltransferase activity
H3V39_RS11760	COG1073	alpha beta
H3V39_RS11760	COG2226	methyltransferase
H3V39_RS11765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H3V39_RS11770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H3V39_RS11780	COG1309	transcriptional regulator
H3V39_RS11790	COG1134	teichoic acid transport
H3V39_RS11795	COG2902	Dehydrogenase
H3V39_RS11815	COG0653	protein targeting
H3V39_RS11830	COG2197	response regulator
H3V39_RS11835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H3V39_RS11845	COG0823	Involved in the tonB-independent uptake of proteins
H3V39_RS11850	COG5002	protein histidine kinase activity
H3V39_RS11850	COG5000	phosphorelay sensor kinase activity
H3V39_RS11855	COG0745	RESPONSE REGULATOR receiver
H3V39_RS11860	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H3V39_RS11880	COG0714	Associated with various cellular activities
H3V39_RS11920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H3V39_RS11940	COG2835	tetraacyldisaccharide 4'-kinase activity
H3V39_RS11945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3V39_RS11980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H3V39_RS11985	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H3V39_RS11985	COG0778	Nitroreductase
H3V39_RS11990	COG0531	amino acid
H3V39_RS12015	COG1316	TRANSCRIPTIONal
H3V39_RS12020	COG1316	TRANSCRIPTIONal
H3V39_RS12025	COG1316	TRANSCRIPTIONal
H3V39_RS12030	COG1316	TRANSCRIPTIONal
H3V39_RS12040	COG1316	TRANSCRIPTIONal
H3V39_RS12085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H3V39_RS12115	COG2205	protein histidine kinase activity
H3V39_RS12120	COG0745	RESPONSE REGULATOR receiver
H3V39_RS12125	COG3104	oligopeptide transport
H3V39_RS12155	COG1366	Belongs to the anti-sigma-factor antagonist family
H3V39_RS12160	COG1191	sigma factor activity
H3V39_RS12165	COG1228	amidohydrolase
H3V39_RS12175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3V39_RS12180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H3V39_RS12185	COG0531	amino acid
H3V39_RS12235	COG2755	lipolytic protein G-D-S-L family
H3V39_RS12240	COG0183	Belongs to the thiolase family
H3V39_RS12265	COG1136	(ABC) transporter
H3V39_RS12265	COG0577	efflux transmembrane transporter activity
H3V39_RS12270	COG0577	efflux transmembrane transporter activity
H3V39_RS12270	COG1136	(ABC) transporter
H3V39_RS12275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H3V39_RS12280	COG1252	NADH dehydrogenase
H3V39_RS12300	COG0148	phosphopyruvate hydratase activity
H3V39_RS12310	COG1652	LysM domain
H3V39_RS12335	COG0515	serine threonine protein kinase
H3V39_RS12335	COG2815	serine threonine protein kinase
H3V39_RS12355	COG1335	isochorismatase
H3V39_RS12360	COG0456	acetyltransferase
H3V39_RS12430	COG1473	amidohydrolase
H3V39_RS12495	COG0577	efflux transmembrane transporter activity
H3V39_RS12500	COG1136	(ABC) transporter
H3V39_RS12505	COG0477	Major facilitator Superfamily
H3V39_RS12510	COG0346	lactoylglutathione lyase activity
H3V39_RS12545	COG2124	cytochrome p450
H3V39_RS12575	COG4585	Histidine kinase
H3V39_RS12585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H3V39_RS12590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H3V39_RS12595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H3V39_RS12600	COG0193	aminoacyl-tRNA hydrolase activity
H3V39_RS12605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H3V39_RS12630	COG4106	trans-aconitate 2-methyltransferase activity
H3V39_RS12635	COG1846	Transcriptional regulator
H3V39_RS12640	COG2197	response regulator
H3V39_RS12650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H3V39_RS12665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3V39_RS12690	COG0488	(ABC) transporter
H3V39_RS12710	COG2161	toxin-antitoxin pair type II binding
H3V39_RS12715	COG4115	mRNA cleavage
H3V39_RS12730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H3V39_RS12735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H3V39_RS12740	COG0084	hydrolase, TatD family'
H3V39_RS12770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H3V39_RS12815	COG2223	nitrite transmembrane transporter activity
H3V39_RS12820	COG2207	Transcriptional regulator
H3V39_RS12825	COG0442	prolyl-tRNA aminoacylation
H3V39_RS12845	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
H3V39_RS12850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H3V39_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS12875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H3V39_RS12885	COG2409	Drug exporters of the RND superfamily
H3V39_RS12895	COG4946	Tricorn protease homolog
H3V39_RS12895	COG0793	Belongs to the peptidase S41A family
H3V39_RS12910	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS12920	COG2072	flavoprotein involved in K transport
H3V39_RS12930	COG0708	Exodeoxyribonuclease III
H3V39_RS12960	COG2340	Cysteine-rich secretory protein family
H3V39_RS13000	COG0521	Mo-molybdopterin cofactor biosynthetic process
H3V39_RS13005	COG0315	cyclic pyranopterin monophosphate synthase activity
H3V39_RS13015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H3V39_RS13020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H3V39_RS13045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H3V39_RS13070	COG0437	4 iron, 4 sulfur cluster binding
H3V39_RS13075	COG0243	molybdopterin cofactor binding
H3V39_RS13095	COG0477	Major facilitator Superfamily
H3V39_RS13120	COG3384	dioxygenase
H3V39_RS13125	COG1846	Transcriptional regulator
H3V39_RS13145	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS13180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS13215	COG1475	DNA binding
H3V39_RS13315	COG1324	tolerance protein
H3V39_RS13340	COG0494	nUDIX hydrolase
H3V39_RS13385	COG1686	Belongs to the peptidase S11 family
H3V39_RS13455	COG4106	trans-aconitate 2-methyltransferase activity
H3V39_RS13475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H3V39_RS13490	COG3386	PFAM SMP-30 Gluconolaconase
H3V39_RS13495	COG0768	penicillin binding
H3V39_RS13605	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
H3V39_RS13615	COG0183	Belongs to the thiolase family
H3V39_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS13635	COG2770	Histidine kinase
H3V39_RS13635	COG2208	phosphoserine phosphatase activity
H3V39_RS13655	COG1309	transcriptional regulator
H3V39_RS13665	COG1301	dicarboxylic acid transport
H3V39_RS13675	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H3V39_RS13685	COG0163	prenyltransferase activity
H3V39_RS13700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H3V39_RS13710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H3V39_RS13715	COG1333	cytochrome c biogenesis protein
H3V39_RS13720	COG0785	Cytochrome C biogenesis protein
H3V39_RS13725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3V39_RS13735	COG0406	alpha-ribazole phosphatase activity
H3V39_RS13740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H3V39_RS13770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H3V39_RS13775	COG1690	Belongs to the RtcB family
H3V39_RS13800	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H3V39_RS13805	COG0018	arginyl-trna synthetase
H3V39_RS13840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H3V39_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS13885	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS13890	COG0515	serine threonine protein kinase
H3V39_RS13940	COG2267	carboxylic ester hydrolase activity
H3V39_RS14010	COG0671	phosphoesterase, PA-phosphatase related
H3V39_RS14025	COG0667	Aldo Keto reductase
H3V39_RS14030	COG1309	transcriptional regulator
H3V39_RS14060	COG2252	PERMEase
H3V39_RS14070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H3V39_RS14090	COG2814	Major facilitator Superfamily
H3V39_RS14100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H3V39_RS14105	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H3V39_RS14115	COG1278	Cold shock
H3V39_RS14140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS14145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS14150	COG1120	ATPase activity
H3V39_RS14155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3V39_RS14200	COG1061	Type III restriction enzyme res subunit
H3V39_RS14210	COG1120	ATPase activity
H3V39_RS14235	COG3973	AAA domain
H3V39_RS14255	COG1984	allophanate hydrolase subunit 2
H3V39_RS14260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H3V39_RS14265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H3V39_RS14275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3V39_RS14280	COG0640	Transcriptional regulator
H3V39_RS14285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H3V39_RS14315	COG1737	Transcriptional regulator
H3V39_RS14320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H3V39_RS14350	COG4257	antibiotic catabolic process
H3V39_RS14375	COG2154	pterin-4-alpha-carbinolamine dehydratase
H3V39_RS14405	COG0643	Histidine kinase
H3V39_RS14405	COG0784	Response regulator, receiver
H3V39_RS14405	COG2198	Histidine kinase
H3V39_RS14410	COG4251	negative regulation of phosphorylation
H3V39_RS14450	COG1175	transmembrane transport
H3V39_RS14455	COG0395	ABC-type sugar transport system, permease component
H3V39_RS14475	COG2318	DinB family
H3V39_RS14490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H3V39_RS14535	COG1595	DNA-templated transcription, initiation
H3V39_RS14545	COG1132	(ABC) transporter
H3V39_RS14595	COG0463	Glycosyl transferase, family 2
H3V39_RS14600	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H3V39_RS14610	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H3V39_RS14635	COG2197	response regulator
H3V39_RS14670	COG1131	(ABC) transporter
H3V39_RS14685	COG1136	(ABC) transporter
H3V39_RS14685	COG0577	efflux transmembrane transporter activity
H3V39_RS14695	COG2197	response regulator
H3V39_RS14710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H3V39_RS14715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H3V39_RS14720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H3V39_RS14720	COG1754	DNA topoisomerase type I activity
H3V39_RS14730	COG2890	protein-(glutamine-N5) methyltransferase activity
H3V39_RS14740	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H3V39_RS14750	COG1366	Belongs to the anti-sigma-factor antagonist family
H3V39_RS14755	COG1111	helicase
H3V39_RS14755	COG1205	dead DEAH box helicase
H3V39_RS14815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3V39_RS14820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H3V39_RS14830	COG2267	carboxylic ester hydrolase activity
H3V39_RS14855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H3V39_RS14865	COG0251	oxidation-reduction process
H3V39_RS14880	COG0003	Pfam Anion-transporting ATPase
H3V39_RS14890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H3V39_RS14895	COG1610	YqeY-like protein
H3V39_RS14900	COG1408	metallophosphoesterase
H3V39_RS14975	COG1002	Type II restriction enzyme, methylase subunits
H3V39_RS15005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3V39_RS15010	COG2755	lipolytic protein G-D-S-L family
H3V39_RS15020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H3V39_RS15040	COG1595	DNA-templated transcription, initiation
H3V39_RS15080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H3V39_RS15085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H3V39_RS15100	COG1802	Transcriptional regulator
H3V39_RS15105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H3V39_RS15110	COG0693	protein deglycase activity
H3V39_RS15120	COG2124	cytochrome p450
H3V39_RS15145	COG3226	Transcriptional regulator
H3V39_RS15150	COG0667	Aldo Keto reductase
H3V39_RS15175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS15185	COG0662	Cupin 2, conserved barrel domain protein
H3V39_RS15190	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS15245	COG0590	tRNA wobble adenosine to inosine editing
H3V39_RS15255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H3V39_RS15285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H3V39_RS15305	COG2124	cytochrome p450
H3V39_RS15310	COG2197	response regulator
H3V39_RS15315	COG4585	Histidine kinase
H3V39_RS15320	COG0702	epimerase
H3V39_RS15330	COG3844	kynureninase activity
H3V39_RS15345	COG0477	Major facilitator Superfamily
H3V39_RS15350	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H3V39_RS15355	COG0191	fructose-bisphosphate aldolase activity
H3V39_RS15360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H3V39_RS15375	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H3V39_RS15400	COG0542	response to heat
H3V39_RS15445	COG0789	Transcriptional regulator
H3V39_RS15450	COG0484	heat shock protein binding
H3V39_RS15455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H3V39_RS15460	COG0443	Heat shock 70 kDa protein
H3V39_RS15465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3V39_RS15470	COG0247	lactate metabolic process
H3V39_RS15470	COG2181	nitrate reductase activity
H3V39_RS15490	COG0717	Belongs to the dCTP deaminase family
H3V39_RS15515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H3V39_RS15560	COG1309	transcriptional regulator
H3V39_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS15655	COG1686	Belongs to the peptidase S11 family
H3V39_RS15660	COG2205	protein histidine kinase activity
H3V39_RS15665	COG0745	RESPONSE REGULATOR receiver
H3V39_RS15740	COG0513	Belongs to the DEAD box helicase family
H3V39_RS15745	COG1278	Cold shock
H3V39_RS15795	COG0450	alkyl hydroperoxide reductase
H3V39_RS15805	COG2268	Band 7 protein
H3V39_RS15845	COG0490	domain, Protein
H3V39_RS15850	COG0475	glutathione-regulated potassium exporter activity
H3V39_RS15855	COG0181	hydroxymethylbilane synthase activity
H3V39_RS15880	COG2255	four-way junction helicase activity
H3V39_RS15890	COG0180	Tryptophanyl-tRNA synthetase
H3V39_RS15900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS15935	COG0431	NADPH-dependent FMN reductase
H3V39_RS15960	COG2304	oxidoreductase activity
H3V39_RS15965	COG2205	protein histidine kinase activity
H3V39_RS15970	COG0745	RESPONSE REGULATOR receiver
H3V39_RS15975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3V39_RS15990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H3V39_RS16005	COG1741	Belongs to the pirin family
H3V39_RS16015	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS16025	COG1362	aminopeptidase activity
H3V39_RS16035	COG3629	intracellular signal transduction
H3V39_RS16035	COG3903	Transcriptional regulator
H3V39_RS16060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H3V39_RS16070	COG2271	Major facilitator Superfamily
H3V39_RS16075	COG1802	Transcriptional regulator
H3V39_RS16085	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3V39_RS16090	COG0022	dehydrogenase e1 component
H3V39_RS16115	COG0515	serine threonine protein kinase
H3V39_RS16120	COG0515	serine threonine protein kinase
H3V39_RS16135	COG1136	(ABC) transporter
H3V39_RS16135	COG4591	ABC-type transport system involved in lipoprotein release permease component
H3V39_RS16160	COG0303	'Molybdopterin
H3V39_RS16185	COG1522	sequence-specific DNA binding
H3V39_RS16190	COG1309	transcriptional regulator
H3V39_RS16215	COG3396	Phenylacetate-CoA oxygenase
H3V39_RS16220	COG3460	Phenylacetate-CoA oxygenase
H3V39_RS16225	COG3396	Phenylacetate-CoA oxygenase
H3V39_RS16230	COG2151	metal-sulfur cluster biosynthetic enzyme
H3V39_RS16235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H3V39_RS16270	COG1716	ATPase activity
H3V39_RS16275	COG1716	ATPase activity
H3V39_RS16290	COG0768	penicillin binding
H3V39_RS16295	COG0515	serine threonine protein kinase
H3V39_RS16300	COG3764	Sortase (surface protein transpeptidase)
H3V39_RS16305	COG3764	Sortase (surface protein transpeptidase)
H3V39_RS16320	COG3764	Sortase (surface protein transpeptidase)
H3V39_RS16360	COG0515	serine threonine protein kinase
H3V39_RS16395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3V39_RS16405	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H3V39_RS16410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H3V39_RS16415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H3V39_RS16420	COG0592	DNA-directed DNA polymerase activity
H3V39_RS16435	COG0594	ribonuclease P activity
H3V39_RS16440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H3V39_RS16445	COG0706	membrane insertase activity
H3V39_RS16455	COG0357	Ribosomal RNA small subunit methyltransferase G
H3V39_RS16460	COG1192	Involved in chromosome partitioning
H3V39_RS16475	COG3118	belongs to the thioredoxin family
H3V39_RS16480	COG0492	ferredoxin-NADP+ reductase activity
H3V39_RS16490	COG1595	DNA-templated transcription, initiation
H3V39_RS16495	COG0515	serine threonine protein kinase
H3V39_RS16495	COG2815	serine threonine protein kinase
H3V39_RS16530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3V39_RS16555	COG0360	Binds together with S18 to 16S ribosomal RNA
H3V39_RS16560	COG0629	single-stranded DNA binding
H3V39_RS16565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H3V39_RS16570	COG0359	binds to the 23S rRNA
H3V39_RS16580	COG0305	Participates in initiation and elongation during chromosome replication
H3V39_RS16610	COG2814	Major facilitator Superfamily
H3V39_RS16625	COG0626	cystathionine gamma-synthase activity
H3V39_RS16630	COG1950	PFAM Membrane protein of
H3V39_RS16635	COG0662	Cupin 2, conserved barrel domain protein
H3V39_RS16660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H3V39_RS16670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H3V39_RS16675	COG1609	Transcriptional regulator
H3V39_RS16680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H3V39_RS16685	COG1271	oxidase subunit
H3V39_RS16690	COG1294	oxidase, subunit
H3V39_RS16695	COG4988	ABC transporter
H3V39_RS16705	COG0561	phosphatase activity
H3V39_RS16715	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H3V39_RS16720	COG0789	Transcriptional regulator
H3V39_RS16735	COG1131	(ABC) transporter
H3V39_RS16760	COG0561	phosphatase activity
H3V39_RS16765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H3V39_RS16775	COG2837	iron assimilation
H3V39_RS16780	COG2372	response to copper ion
H3V39_RS16790	COG1999	signal sequence binding
H3V39_RS16810	COG0006	proline dipeptidase activity
H3V39_RS16825	COG0653	protein targeting
H3V39_RS16840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3V39_RS16865	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS16890	COG1595	DNA-templated transcription, initiation
H3V39_RS16895	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS16930	COG1252	NADH dehydrogenase
H3V39_RS16935	COG1595	DNA-templated transcription, initiation
H3V39_RS16955	COG0745	RESPONSE REGULATOR receiver
H3V39_RS16975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H3V39_RS16985	COG0477	Major facilitator Superfamily
H3V39_RS17000	COG3467	pyridoxamine 5'-phosphate
H3V39_RS17005	COG2353	YceI-like domain
H3V39_RS17030	COG1191	sigma factor activity
H3V39_RS17035	COG1191	sigma factor activity
H3V39_RS17075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H3V39_RS17090	COG2234	aminopeptidase activity
H3V39_RS17110	COG2197	response regulator
H3V39_RS17125	COG0464	growth
H3V39_RS17205	COG4941	Belongs to the sigma-70 factor family
H3V39_RS17235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H3V39_RS17350	COG0151	Belongs to the GarS family
H3V39_RS17365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H3V39_RS17375	COG2197	response regulator
H3V39_RS17390	COG1131	(ABC) transporter
H3V39_RS17410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3V39_RS17415	COG0047	phosphoribosylformylglycinamidine synthase activity
H3V39_RS17420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3V39_RS17450	COG3119	arylsulfatase activity
H3V39_RS17460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H3V39_RS17470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H3V39_RS17490	COG1643	Atp-dependent helicase
H3V39_RS17500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H3V39_RS17500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H3V39_RS17505	COG0785	Cytochrome C biogenesis protein
H3V39_RS17535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3V39_RS17540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3V39_RS17550	COG0513	Belongs to the DEAD box helicase family
H3V39_RS17570	COG1937	Protein conserved in bacteria
H3V39_RS17585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H3V39_RS17585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H3V39_RS17590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H3V39_RS17595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H3V39_RS17615	COG1196	nuclear chromosome segregation
H3V39_RS17615	COG0739	heme binding
H3V39_RS17615	COG0741	lytic transglycosylase activity
H3V39_RS17630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H3V39_RS17635	COG0579	oxidoreductase
H3V39_RS17660	COG1252	NADH dehydrogenase
H3V39_RS17675	COG1846	Transcriptional regulator
H3V39_RS17695	COG2197	response regulator
H3V39_RS17700	COG4585	Histidine kinase
H3V39_RS17780	COG0739	heme binding
H3V39_RS17780	COG1196	nuclear chromosome segregation
H3V39_RS17780	COG0741	lytic transglycosylase activity
H3V39_RS17785	COG0671	phosphoesterase, PA-phosphatase related
H3V39_RS17805	COG1937	Protein conserved in bacteria
H3V39_RS17815	COG0306	phosphate transporter
H3V39_RS17835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H3V39_RS17840	COG0406	alpha-ribazole phosphatase activity
H3V39_RS17840	COG0494	nUDIX hydrolase
H3V39_RS17860	COG1116	anion transmembrane transporter activity
H3V39_RS17865	COG1725	Transcriptional regulator
H3V39_RS17870	COG0456	acetyltransferase
H3V39_RS17880	COG0737	Belongs to the 5'-nucleotidase family
H3V39_RS17890	COG0154	amidase activity
H3V39_RS17905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS17915	COG4977	sequence-specific DNA binding
H3V39_RS17930	COG0739	heme binding
H3V39_RS17965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3V39_RS17970	COG1609	Transcriptional regulator
H3V39_RS17975	COG0745	RESPONSE REGULATOR receiver
H3V39_RS18000	COG2897	thiosulfate sulfurtransferase activity
H3V39_RS18020	COG3485	protocatechuate 3,4-dioxygenase
H3V39_RS18025	COG0735	belongs to the Fur family
H3V39_RS18035	COG1490	D-aminoacyl-tRNA deacylase activity
H3V39_RS18050	COG4552	Acetyltransferase involved in intracellular survival and related
H3V39_RS18090	COG4942	peptidase
H3V39_RS18160	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS18205	COG0640	Transcriptional regulator
H3V39_RS18210	COG0798	PFAM Bile acid sodium symporter
H3V39_RS18215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H3V39_RS18225	COG0588	phosphoglycerate mutase activity
H3V39_RS18245	COG5002	protein histidine kinase activity
H3V39_RS18260	COG1329	Transcriptional regulator
H3V39_RS18265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H3V39_RS18270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H3V39_RS18285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS18295	COG3467	pyridoxamine 5'-phosphate
H3V39_RS18300	COG0215	cysteine-tRNA ligase activity
H3V39_RS18325	COG3842	ATPase activity
H3V39_RS18385	COG0745	RESPONSE REGULATOR receiver
H3V39_RS18430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3V39_RS18450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H3V39_RS18470	COG2197	response regulator
H3V39_RS18505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H3V39_RS18530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H3V39_RS18540	COG1653	transport
H3V39_RS18600	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS18635	COG0076	glutamate decarboxylase activity
H3V39_RS18640	COG0655	NAD(P)H dehydrogenase (quinone) activity
H3V39_RS18650	COG0393	Putative heavy-metal-binding
H3V39_RS18655	COG0586	Pfam SNARE associated Golgi protein
H3V39_RS18665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H3V39_RS18670	COG2027	D-alanyl-D-alanine carboxypeptidase
H3V39_RS18680	COG0037	tRNA processing
H3V39_RS18695	COG0302	gtp cyclohydrolase
H3V39_RS18710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H3V39_RS18725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H3V39_RS18725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H3V39_RS18735	COG1125	glycine betaine transport
H3V39_RS18735	COG0517	IMP dehydrogenase activity
H3V39_RS18740	COG1174	glycine betaine transport
H3V39_RS18745	COG1174	glycine betaine transport
H3V39_RS18760	COG0649	NAD binding
H3V39_RS18775	COG2197	response regulator
H3V39_RS18780	COG1660	Displays ATPase and GTPase activities
H3V39_RS18805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H3V39_RS18810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H3V39_RS18820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H3V39_RS18840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H3V39_RS18870	COG0739	heme binding
H3V39_RS18875	COG2205	protein histidine kinase activity
H3V39_RS18880	COG0745	RESPONSE REGULATOR receiver
H3V39_RS18890	COG1595	DNA-templated transcription, initiation
H3V39_RS18895	COG1194	a g-specific adenine glycosylase
H3V39_RS18905	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H3V39_RS18925	COG0248	Ppx GppA phosphatase
H3V39_RS18930	COG1082	Xylose isomerase domain protein TIM barrel
H3V39_RS18940	COG0129	dihydroxy-acid dehydratase activity
H3V39_RS18945	COG0515	serine threonine protein kinase
H3V39_RS18945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3V39_RS18950	COG4991	sh3 domain protein
H3V39_RS18960	COG1129	ABC transporter
H3V39_RS18960	COG0842	Transport permease protein
H3V39_RS18970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H3V39_RS18990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS19050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H3V39_RS19055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H3V39_RS19060	COG0181	hydroxymethylbilane synthase activity
H3V39_RS19065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H3V39_RS19065	COG1648	precorrin-2 dehydrogenase activity
H3V39_RS19070	COG0113	porphobilinogen synthase activity
H3V39_RS19105	COG2318	DinB family
H3V39_RS19130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H3V39_RS19155	COG2161	toxin-antitoxin pair type II binding
H3V39_RS19190	COG1136	(ABC) transporter
H3V39_RS19190	COG0577	efflux transmembrane transporter activity
H3V39_RS19210	COG0745	RESPONSE REGULATOR receiver
H3V39_RS19215	COG2205	protein histidine kinase activity
H3V39_RS19245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H3V39_RS19260	COG1309	transcriptional regulator
H3V39_RS19325	COG1335	isochorismatase
H3V39_RS19340	COG2318	DinB family
H3V39_RS19350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H3V39_RS19380	COG2205	protein histidine kinase activity
H3V39_RS19385	COG0247	lactate metabolic process
H3V39_RS19385	COG0277	FAD linked oxidase domain protein
H3V39_RS19390	COG0583	DNA-binding transcription factor activity
H3V39_RS19395	COG5006	permease, DMT superfamily
H3V39_RS19425	COG2080	2 iron, 2 sulfur cluster binding
H3V39_RS19425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H3V39_RS19435	COG1051	belongs to the nudix hydrolase family
H3V39_RS19450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3V39_RS19465	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS19470	COG1024	Enoyl-CoA hydratase
H3V39_RS19505	COG1396	sequence-specific DNA binding
H3V39_RS19525	COG0259	pyridoxamine-phosphate oxidase activity
H3V39_RS19535	COG4821	SIS domain
H3V39_RS19590	COG0604	alcohol dehydrogenase
H3V39_RS19620	COG1366	Belongs to the anti-sigma-factor antagonist family
H3V39_RS19635	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS19645	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS19650	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS19665	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS19670	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS19715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H3V39_RS19720	COG1024	Enoyl-CoA hydratase
H3V39_RS19745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3V39_RS19755	COG2072	flavoprotein involved in K transport
H3V39_RS19760	COG4592	Periplasmic binding protein
H3V39_RS19765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS19770	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS19785	COG2124	cytochrome p450
H3V39_RS19800	COG0501	Belongs to the peptidase M48B family
H3V39_RS19805	COG0259	pyridoxamine-phosphate oxidase activity
H3V39_RS19825	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS19835	COG1309	transcriptional regulator
H3V39_RS19860	COG1024	Enoyl-CoA hydratase
H3V39_RS19875	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS19905	COG0789	Transcriptional regulator
H3V39_RS19910	COG1278	Cold shock
H3V39_RS19915	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H3V39_RS19925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H3V39_RS19950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3V39_RS19955	COG4521	taurine ABC transporter
H3V39_RS19965	COG2175	clavaminate synthase activity
H3V39_RS19970	COG2226	methyltransferase
H3V39_RS20035	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3V39_RS20040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3V39_RS20045	COG0649	NAD binding
H3V39_RS20055	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H3V39_RS20060	COG1034	ATP synthesis coupled electron transport
H3V39_RS20065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H3V39_RS20070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3V39_RS20075	COG0839	Belongs to the complex I subunit 6 family
H3V39_RS20080	COG0713	ATP synthesis coupled electron transport
H3V39_RS20085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H3V39_RS20095	COG1007	ATP synthesis coupled electron transport
H3V39_RS20100	COG0514	ATP-dependent DNA helicase (RecQ)
H3V39_RS20135	COG3104	oligopeptide transport
H3V39_RS20140	COG0142	geranyltranstransferase activity
H3V39_RS20165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3V39_RS20165	COG0515	serine threonine protein kinase
H3V39_RS20195	COG0561	phosphatase activity
H3V39_RS20205	COG0667	Aldo Keto reductase
H3V39_RS20295	COG0702	epimerase
H3V39_RS20300	COG1733	regulation of RNA biosynthetic process
H3V39_RS20305	COG1013	pyruvate-flavodoxin oxidoreductase activity
H3V39_RS20310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H3V39_RS20310	COG0674	pyruvate-flavodoxin oxidoreductase activity
H3V39_RS20325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3V39_RS20335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3V39_RS20340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H3V39_RS20345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3V39_RS20355	COG0713	ATP synthesis coupled electron transport
H3V39_RS20370	COG1007	ATP synthesis coupled electron transport
H3V39_RS20375	COG1970	mechanosensitive ion channel activity
H3V39_RS20380	COG0501	Belongs to the peptidase M48B family
H3V39_RS20385	COG3304	Inner membrane component domain
H3V39_RS20400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3V39_RS20405	COG1666	GTP binding
H3V39_RS20415	COG0702	epimerase
H3V39_RS20435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3V39_RS20440	COG2030	dehydratase
H3V39_RS20460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H3V39_RS20465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3V39_RS20470	COG0436	Aminotransferase
H3V39_RS20490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H3V39_RS20495	COG0081	regulation of translation
H3V39_RS20505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H3V39_RS20510	COG0222	ribosome binding
H3V39_RS20515	COG0085	RNA polymerase activity
H3V39_RS20520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H3V39_RS20525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H3V39_RS20610	COG0739	heme binding
H3V39_RS20610	COG0741	lytic transglycosylase activity
H3V39_RS20610	COG1196	nuclear chromosome segregation
H3V39_RS20625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H3V39_RS20630	COG0049	tRNA binding
H3V39_RS20635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H3V39_RS20640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H3V39_RS20645	COG4585	Histidine kinase
H3V39_RS20650	COG2197	response regulator
H3V39_RS20665	COG0051	transcription antitermination factor activity, RNA binding
H3V39_RS20670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H3V39_RS20675	COG0088	Forms part of the polypeptide exit tunnel
H3V39_RS20680	COG0089	rRNA binding
H3V39_RS20685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H3V39_RS20690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H3V39_RS20695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H3V39_RS20700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H3V39_RS20705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H3V39_RS20710	COG0255	Belongs to the universal ribosomal protein uL29 family
H3V39_RS20715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H3V39_RS20720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H3V39_RS20725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H3V39_RS20730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H3V39_RS20735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H3V39_RS20740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H3V39_RS20745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H3V39_RS20750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H3V39_RS20755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H3V39_RS20760	COG1841	ribosomal large subunit assembly
H3V39_RS20765	COG0200	Binds to the 23S rRNA
H3V39_RS20775	COG0563	adenylate kinase activity
H3V39_RS20785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H3V39_RS20790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H3V39_RS20795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H3V39_RS20800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H3V39_RS20805	COG0202	RNA polymerase activity
H3V39_RS20810	COG0203	ribosomal protein L17
H3V39_RS20815	COG0101	tRNA pseudouridine synthase activity
H3V39_RS20825	COG0488	(ABC) transporter
H3V39_RS20830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H3V39_RS20835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H3V39_RS20840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3V39_RS20850	COG1072	(Pantothenic acid kinase))
H3V39_RS20910	COG0596	Alpha beta hydrolase
H3V39_RS20920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3V39_RS20925	COG0736	holo-[acyl-carrier-protein] synthase activity
H3V39_RS20935	COG3189	MarR family transcriptional regulator
H3V39_RS20950	COG0802	atpase or kinase
H3V39_RS20975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H3V39_RS21010	COG0726	polysaccharide deacetylase
H3V39_RS21020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H3V39_RS21035	COG2132	Multicopper oxidase
H3V39_RS21050	COG0583	DNA-binding transcription factor activity
H3V39_RS21065	COG1595	DNA-templated transcription, initiation
H3V39_RS21075	COG0516	GMP reductase activity
H3V39_RS21105	COG0515	serine threonine protein kinase
H3V39_RS21115	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS21135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H3V39_RS21135	COG0519	Catalyzes the synthesis of GMP from XMP
H3V39_RS21145	COG4106	trans-aconitate 2-methyltransferase activity
H3V39_RS21175	COG2197	response regulator
H3V39_RS21180	COG0791	NLP P60 protein
H3V39_RS21200	COG0739	heme binding
H3V39_RS21210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3V39_RS21230	COG0714	Associated with various cellular activities
H3V39_RS21240	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H3V39_RS21245	COG0045	succinate-CoA ligase (ADP-forming) activity
H3V39_RS21275	COG0138	bifunctional purine biosynthesis protein purh
H3V39_RS21290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H3V39_RS21305	COG0039	L-malate dehydrogenase activity
H3V39_RS21325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3V39_RS21330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H3V39_RS21340	COG0754	glutathionylspermidine amidase activity
H3V39_RS21345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3V39_RS21350	COG0180	Tryptophanyl-tRNA synthetase
H3V39_RS21370	COG1295	ribonuclease BN
H3V39_RS21385	COG1408	metallophosphoesterase
H3V39_RS21420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H3V39_RS21425	COG1053	succinate dehydrogenase
H3V39_RS21435	COG2009	succinate dehydrogenase
H3V39_RS21485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H3V39_RS21490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H3V39_RS21495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H3V39_RS21510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H3V39_RS21520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H3V39_RS21535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3V39_RS21545	COG0402	S-adenosylhomocysteine deaminase activity
H3V39_RS21550	COG1335	isochorismatase
H3V39_RS21560	COG0189	ligase activity
H3V39_RS21570	COG0602	queuosine metabolic process
H3V39_RS21575	COG0302	gtp cyclohydrolase
H3V39_RS21580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H3V39_RS21585	COG0367	asparagine synthase
H3V39_RS21605	COG0667	Aldo Keto reductase
H3V39_RS21655	COG1595	DNA-templated transcription, initiation
H3V39_RS21695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H3V39_RS21705	COG1216	Glycosyl transferase, family 2
H3V39_RS21715	COG1083	cytidylyl-transferase
H3V39_RS21720	COG2089	acid synthase
H3V39_RS21730	COG1473	amidohydrolase
H3V39_RS21730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H3V39_RS21735	COG1744	ABC transporter substrate-binding protein PnrA-like
H3V39_RS21740	COG3845	ABC transporter
H3V39_RS21745	COG4603	Belongs to the binding-protein-dependent transport system permease family
H3V39_RS21750	COG1079	Belongs to the binding-protein-dependent transport system permease family
H3V39_RS21770	COG1404	Belongs to the peptidase S8 family
H3V39_RS21790	COG2814	Major facilitator Superfamily
H3V39_RS21795	COG0583	DNA-binding transcription factor activity
H3V39_RS21810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3V39_RS21835	COG2205	protein histidine kinase activity
H3V39_RS21840	COG0745	RESPONSE REGULATOR receiver
H3V39_RS21845	COG1595	DNA-templated transcription, initiation
H3V39_RS21860	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS21865	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS21880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3V39_RS21910	COG4770	biotin carboxylase activity
H3V39_RS21920	COG0424	maF-like protein
H3V39_RS21930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3V39_RS21945	COG1024	Enoyl-CoA hydratase
H3V39_RS21970	COG1376	ErfK ybiS ycfS ynhG family protein
H3V39_RS21990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H3V39_RS21995	COG1396	sequence-specific DNA binding
H3V39_RS22010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3V39_RS22015	COG0583	DNA-binding transcription factor activity
H3V39_RS22030	COG0501	Belongs to the peptidase M48B family
H3V39_RS22055	COG1595	DNA-templated transcription, initiation
H3V39_RS22060	COG0745	RESPONSE REGULATOR receiver
H3V39_RS22065	COG2205	protein histidine kinase activity
H3V39_RS22065	COG2202	Pas domain
H3V39_RS22075	COG2172	sigma factor antagonist activity
H3V39_RS22080	COG1366	Belongs to the anti-sigma-factor antagonist family
H3V39_RS22085	COG1366	Belongs to the anti-sigma-factor antagonist family
H3V39_RS22095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H3V39_RS22110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H3V39_RS22120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H3V39_RS22145	COG2197	response regulator
H3V39_RS22150	COG1136	(ABC) transporter
H3V39_RS22150	COG0577	efflux transmembrane transporter activity
H3V39_RS22160	COG4585	Histidine kinase
H3V39_RS22180	COG1331	Highly conserved protein containing a thioredoxin domain
H3V39_RS22190	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H3V39_RS22200	COG0436	Aminotransferase
H3V39_RS22220	COG1733	regulation of RNA biosynthetic process
H3V39_RS22240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H3V39_RS22255	COG1414	Transcriptional regulator
H3V39_RS22260	COG0251	oxidation-reduction process
H3V39_RS22265	COG2610	gluconate transmembrane transporter activity
H3V39_RS22290	COG2894	cell division
H3V39_RS22325	COG2197	response regulator
H3V39_RS22345	COG2885	chlorophyll binding
H3V39_RS22410	COG2226	methyltransferase
H3V39_RS22420	COG0667	Aldo Keto reductase
H3V39_RS22425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3V39_RS22430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H3V39_RS22445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3V39_RS22450	COG0450	alkyl hydroperoxide reductase
H3V39_RS22465	COG1136	(ABC) transporter
H3V39_RS22485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3V39_RS22485	COG4499	WXG100 protein secretion system (Wss), protein YukC
H3V39_RS22500	COG0114	fumarate hydratase activity
H3V39_RS22510	COG1362	aminopeptidase activity
H3V39_RS22545	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H3V39_RS22545	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H3V39_RS22570	COG0778	Nitroreductase
H3V39_RS22575	COG1722	exodeoxyribonuclease VII activity
H3V39_RS22580	COG1570	exodeoxyribonuclease VII activity
H3V39_RS22590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H3V39_RS22605	COG0012	GTP binding
H3V39_RS22620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3V39_RS22760	COG0789	Transcriptional regulator
H3V39_RS22830	COG1217	gtp-binding protein TYPA
H3V39_RS22840	COG0601	transmembrane transport
H3V39_RS22845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS22855	COG4608	Belongs to the ABC transporter superfamily
H3V39_RS22860	COG4166	transmembrane transport
H3V39_RS22865	COG0601	transmembrane transport
H3V39_RS22870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS22880	COG4608	Belongs to the ABC transporter superfamily
H3V39_RS22895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H3V39_RS22915	COG0110	maltose O-acetyltransferase activity
H3V39_RS22930	COG0515	serine threonine protein kinase
H3V39_RS22945	COG1132	(ABC) transporter
H3V39_RS22950	COG2197	response regulator
H3V39_RS22955	COG2912	Transglutaminase-like superfamily
H3V39_RS22985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3V39_RS22990	COG1611	Belongs to the LOG family
H3V39_RS22995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H3V39_RS23005	COG0519	Catalyzes the synthesis of GMP from XMP
H3V39_RS23010	COG1024	Enoyl-CoA hydratase
H3V39_RS23025	COG1595	DNA-templated transcription, initiation
H3V39_RS23035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3V39_RS23040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H3V39_RS23075	COG0598	Magnesium transport protein CorA
H3V39_RS23085	COG2814	Major facilitator Superfamily
H3V39_RS23100	COG2095	MarC family integral membrane protein
H3V39_RS23110	COG1432	Conserved Protein
H3V39_RS23120	COG0513	Belongs to the DEAD box helicase family
H3V39_RS23160	COG0747	negative chemotaxis
H3V39_RS23165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS23170	COG0601	transmembrane transport
H3V39_RS23220	COG0210	DNA helicase
H3V39_RS23320	COG3480	Lon protease (S16) C-terminal proteolytic domain
H3V39_RS23330	COG1615	UPF0182 protein
H3V39_RS23355	COG0753	catalase activity
H3V39_RS23365	COG0483	inositol monophosphate 1-phosphatase activity
H3V39_RS23375	COG2076	Multidrug Resistance protein
H3V39_RS23385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H3V39_RS23395	COG2135	peptidase activity
H3V39_RS23405	COG1595	DNA-templated transcription, initiation
H3V39_RS23410	COG5662	AntiSigma factor
H3V39_RS23420	COG0242	peptide deformylase activity
H3V39_RS23455	COG1966	Carbon starvation protein
H3V39_RS23460	COG2188	Transcriptional regulator
H3V39_RS23465	COG2182	Extracellular solute-binding protein
H3V39_RS23470	COG1175	transmembrane transport
H3V39_RS23475	COG0395	ABC-type sugar transport system, permease component
H3V39_RS23480	COG1472	Belongs to the glycosyl hydrolase 3 family
H3V39_RS23485	COG0363	glucosamine-6-phosphate deaminase activity
H3V39_RS23490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3V39_RS23505	COG1597	lipid kinase activity
H3V39_RS23545	COG1959	2 iron, 2 sulfur cluster binding
H3V39_RS23550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3V39_RS23555	COG0142	geranyltranstransferase activity
H3V39_RS23620	COG2197	response regulator
H3V39_RS23625	COG4585	Histidine kinase
H3V39_RS23645	COG1695	Transcriptional regulator
H3V39_RS23675	COG4106	trans-aconitate 2-methyltransferase activity
H3V39_RS23680	COG1595	DNA-templated transcription, initiation
H3V39_RS23690	COG1126	abc transporter atp-binding protein
H3V39_RS23695	COG0765	amino acid transport
H3V39_RS23700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3V39_RS23705	COG0281	malic enzyme
H3V39_RS23710	COG0604	alcohol dehydrogenase
H3V39_RS23730	COG0542	response to heat
H3V39_RS23755	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3V39_RS23755	COG0567	Dehydrogenase, E1 component
H3V39_RS23760	COG2205	protein histidine kinase activity
H3V39_RS23765	COG0745	RESPONSE REGULATOR receiver
H3V39_RS23775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H3V39_RS23780	COG0726	polysaccharide deacetylase
H3V39_RS23840	COG1309	transcriptional regulator
H3V39_RS23885	COG2205	protein histidine kinase activity
H3V39_RS23905	COG1793	dna ligase
H3V39_RS23905	COG3285	dna ligase
H3V39_RS23910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H3V39_RS23915	COG0515	serine threonine protein kinase
H3V39_RS23925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3V39_RS23950	COG0018	arginyl-trna synthetase
H3V39_RS23955	COG0019	diaminopimelate decarboxylase activity
H3V39_RS23960	COG0460	homoserine dehydrogenase
H3V39_RS23965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H3V39_RS23970	COG0083	homoserine kinase activity
H3V39_RS23980	COG1316	TRANSCRIPTIONal
H3V39_RS23985	COG0254	rRNA binding
H3V39_RS23990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H3V39_RS23995	COG2890	protein-(glutamine-N5) methyltransferase activity
H3V39_RS24005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H3V39_RS24010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3V39_RS24035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3V39_RS24040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H3V39_RS24045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3V39_RS24050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H3V39_RS24055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H3V39_RS24060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H3V39_RS24065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H3V39_RS24080	COG2197	response regulator
H3V39_RS24085	COG4585	Histidine kinase
H3V39_RS24115	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS24130	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H3V39_RS24165	COG1131	(ABC) transporter
H3V39_RS24185	COG0183	Belongs to the thiolase family
H3V39_RS24200	COG0745	RESPONSE REGULATOR receiver
H3V39_RS24205	COG5000	phosphorelay sensor kinase activity
H3V39_RS24205	COG5002	protein histidine kinase activity
H3V39_RS24275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3V39_RS24275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3V39_RS24320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H3V39_RS24325	COG0280	phosphate acetyltransferase
H3V39_RS24325	COG0857	belongs to the CobB CobQ family
H3V39_RS24330	COG0205	6-phosphofructokinase activity
H3V39_RS24340	COG4565	transcriptional regulatory protein
H3V39_RS24345	COG3290	protein histidine kinase activity
H3V39_RS24350	COG1301	dicarboxylic acid transport
H3V39_RS24375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H3V39_RS24385	COG0366	Alpha amylase catalytic
H3V39_RS24390	COG0366	Alpha amylase catalytic
H3V39_RS24395	COG0058	SHG alpha-glucan phosphorylase activity
H3V39_RS24425	COG0583	DNA-binding transcription factor activity
H3V39_RS24440	COG0387	Pfam Sodium calcium exchanger
H3V39_RS24445	COG1132	(ABC) transporter
H3V39_RS24455	COG1131	(ABC) transporter
H3V39_RS24470	COG2197	response regulator
H3V39_RS24605	COG0823	Involved in the tonB-independent uptake of proteins
H3V39_RS24605	COG1506	peptidase
H3V39_RS24615	COG0464	growth
H3V39_RS24645	COG1760	l-serine dehydratase
H3V39_RS24650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3V39_RS24655	COG0509	glycine decarboxylation via glycine cleavage system
H3V39_RS24660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H3V39_RS24680	COG0747	negative chemotaxis
H3V39_RS24685	COG0601	transmembrane transport
H3V39_RS24690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS24700	COG4608	Belongs to the ABC transporter superfamily
H3V39_RS24705	COG2860	membrane
H3V39_RS24715	COG2378	regulation of single-species biofilm formation
H3V39_RS24745	COG0482	sulfurtransferase activity
H3V39_RS24765	COG4221	oxidoreductase activity
H3V39_RS24775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3V39_RS24785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3V39_RS24790	COG0154	amidase activity
H3V39_RS24800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3V39_RS24805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H3V39_RS24815	COG2409	Drug exporters of the RND superfamily
H3V39_RS24830	COG2197	response regulator
H3V39_RS24840	COG2133	pyrroloquinoline quinone binding
H3V39_RS24845	COG0667	Aldo Keto reductase
H3V39_RS24855	COG3300	MHYT domain
H3V39_RS24855	COG5001	Diguanylate cyclase
H3V39_RS24865	COG0440	acetolactate synthase activity
H3V39_RS24870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H3V39_RS24875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H3V39_RS24895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3V39_RS24905	COG2508	Transcriptional regulator
H3V39_RS24910	COG0506	proline dehydrogenase activity
H3V39_RS24915	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS24920	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H3V39_RS24920	COG0778	Nitroreductase
H3V39_RS24935	COG0473	3-isopropylmalate dehydrogenase activity
H3V39_RS24940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H3V39_RS24950	COG2957	Belongs to the agmatine deiminase family
H3V39_RS24960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H3V39_RS24965	COG1472	Belongs to the glycosyl hydrolase 3 family
H3V39_RS25010	COG0542	response to heat
H3V39_RS25035	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H3V39_RS25050	COG3708	Transcriptional regulator
H3V39_RS25050	COG2207	Transcriptional regulator
H3V39_RS25115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS25120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS25125	COG1120	ATPase activity
H3V39_RS25130	COG4607	ABC-type enterochelin transport system periplasmic component
H3V39_RS25135	COG2353	YceI-like domain
H3V39_RS25155	COG1470	cell adhesion involved in biofilm formation
H3V39_RS25155	COG0366	Alpha amylase catalytic
H3V39_RS25160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3V39_RS25180	COG2018	Roadblock/LC7 domain
H3V39_RS25200	COG2018	Roadblock/LC7 domain
H3V39_RS25205	COG5002	protein histidine kinase activity
H3V39_RS25215	COG0179	Fumarylacetoacetate (FAA) hydrolase
H3V39_RS25220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H3V39_RS25265	COG1414	Transcriptional regulator
H3V39_RS25270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H3V39_RS25275	COG0066	3-isopropylmalate dehydratase activity
H3V39_RS25285	COG0776	regulation of translation
H3V39_RS25295	COG1920	GTP binding
H3V39_RS25305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H3V39_RS25310	COG1181	Belongs to the D-alanine--D-alanine ligase family
H3V39_RS25330	COG0351	phosphomethylpyrimidine kinase
H3V39_RS25335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H3V39_RS25340	COG1461	Dihydroxyacetone kinase
H3V39_RS25350	COG0742	ribosomal rna small subunit methyltransferase
H3V39_RS25355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H3V39_RS25370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H3V39_RS25375	COG0571	ribonuclease III activity
H3V39_RS25380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3V39_RS25385	COG1733	regulation of RNA biosynthetic process
H3V39_RS25390	COG2340	Cysteine-rich secretory protein family
H3V39_RS25395	COG1254	Belongs to the acylphosphatase family
H3V39_RS25405	COG1196	nuclear chromosome segregation
H3V39_RS25410	COG0477	Major facilitator Superfamily
H3V39_RS25445	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H3V39_RS25465	COG0228	four-way junction DNA binding
H3V39_RS25470	COG1837	Belongs to the UPF0109 family
H3V39_RS25475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H3V39_RS25480	COG0336	Belongs to the RNA methyltransferase TrmD family
H3V39_RS25485	COG0335	large ribosomal subunit rRNA binding
H3V39_RS25520	COG0792	nuclease activity
H3V39_RS25535	COG1191	sigma factor activity
H3V39_RS25550	COG0052	Belongs to the universal ribosomal protein uS2 family
H3V39_RS25555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H3V39_RS25560	COG0528	UMP kinase activity
H3V39_RS25565	COG0233	cytoplasmic translational termination
H3V39_RS25570	COG0575	Belongs to the CDS family
H3V39_RS25650	COG1192	Involved in chromosome partitioning
H3V39_RS25660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H3V39_RS25675	COG3842	ATPase activity
H3V39_RS25685	COG1136	(ABC) transporter
H3V39_RS25690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H3V39_RS25700	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS25725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H3V39_RS25765	COG1595	DNA-templated transcription, initiation
H3V39_RS25790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H3V39_RS25795	COG3842	ATPase activity
H3V39_RS25800	COG1176	ABC-type spermidine putrescine transport system, permease component I
H3V39_RS25805	COG1177	transmembrane transport
H3V39_RS25810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3V39_RS25840	COG2508	Transcriptional regulator
H3V39_RS25850	COG2814	Major facilitator Superfamily
H3V39_RS25855	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS25860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H3V39_RS25865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H3V39_RS25870	COG0750	zinc metalloprotease
H3V39_RS25875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H3V39_RS25890	COG0442	prolyl-tRNA aminoacylation
H3V39_RS25910	COG0779	Required for maturation of 30S ribosomal subunits
H3V39_RS25925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H3V39_RS25935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H3V39_RS25940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H3V39_RS25975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS25980	COG0601	transmembrane transport
H3V39_RS25985	COG0747	negative chemotaxis
H3V39_RS25990	COG0455	bacterial-type flagellum organization
H3V39_RS26015	COG1404	Belongs to the peptidase S8 family
H3V39_RS26030	COG1404	Belongs to the peptidase S8 family
H3V39_RS26045	COG1674	ftsk spoiiie
H3V39_RS26055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H3V39_RS26060	COG1185	polyribonucleotide nucleotidyltransferase activity
H3V39_RS26065	COG0612	Peptidase, M16
H3V39_RS26070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H3V39_RS26090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H3V39_RS26095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3V39_RS26100	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H3V39_RS26130	COG4999	Histidine kinase
H3V39_RS26130	COG3437	response regulator, receiver
H3V39_RS26130	COG2205	protein histidine kinase activity
H3V39_RS26130	COG3850	Histidine kinase
H3V39_RS26140	COG1674	ftsk spoiiie
H3V39_RS26150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H3V39_RS26160	COG1058	Belongs to the CinA family
H3V39_RS26160	COG1546	Belongs to the CinA family
H3V39_RS26165	COG1396	sequence-specific DNA binding
H3V39_RS26170	COG0783	Belongs to the Dps family
H3V39_RS26180	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS26185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3V39_RS26190	COG1201	RNA secondary structure unwinding
H3V39_RS26195	COG2207	Transcriptional regulator
H3V39_RS26195	COG1917	Cupin 2, conserved barrel domain protein
H3V39_RS26225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H3V39_RS26255	COG0765	amino acid transport
H3V39_RS26260	COG0765	amino acid transport
H3V39_RS26265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3V39_RS26270	COG1126	abc transporter atp-binding protein
H3V39_RS26280	COG2205	protein histidine kinase activity
H3V39_RS26285	COG2358	TRAP transporter, solute receptor (TAXI family
H3V39_RS26290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H3V39_RS26305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H3V39_RS26315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H3V39_RS26320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3V39_RS26330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H3V39_RS26370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H3V39_RS26375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H3V39_RS26380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3V39_RS26395	COG0406	alpha-ribazole phosphatase activity
H3V39_RS26410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H3V39_RS26435	COG0582	viral genome integration into host DNA
H3V39_RS26515	COG2186	Transcriptional regulator
H3V39_RS26520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3V39_RS26545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3V39_RS26550	COG4565	transcriptional regulatory protein
H3V39_RS26555	COG3290	protein histidine kinase activity
H3V39_RS26560	COG0372	Belongs to the citrate synthase family
H3V39_RS26565	COG0372	Belongs to the citrate synthase family
H3V39_RS26575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3V39_RS26580	COG0612	Peptidase, M16
H3V39_RS26595	COG1802	Transcriptional regulator
H3V39_RS26600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3V39_RS26620	COG1435	thymidine kinase activity
H3V39_RS26660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H3V39_RS26675	COG0745	RESPONSE REGULATOR receiver
H3V39_RS26680	COG2205	protein histidine kinase activity
H3V39_RS26705	COG0756	dUTP diphosphatase activity
H3V39_RS26715	COG4591	ABC-type transport system involved in lipoprotein release permease component
H3V39_RS26715	COG1136	(ABC) transporter
H3V39_RS26745	COG0569	domain protein
H3V39_RS26750	COG0531	amino acid
H3V39_RS26755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3V39_RS26830	COG3335	DDE superfamily endonuclease
H3V39_RS26870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H3V39_RS26875	COG4552	Acetyltransferase involved in intracellular survival and related
H3V39_RS26895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H3V39_RS26915	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS26940	COG2814	Major facilitator Superfamily
H3V39_RS26955	COG0596	Alpha beta hydrolase
H3V39_RS26975	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3V39_RS26985	COG3938	Belongs to the proline racemase family
H3V39_RS26995	COG2423	ornithine cyclodeaminase activity
H3V39_RS27000	COG1802	Transcriptional regulator
H3V39_RS27005	COG0006	proline dipeptidase activity
H3V39_RS27015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS27020	COG0601	transmembrane transport
H3V39_RS27035	COG3291	Pkd domain containing protein
H3V39_RS27045	COG1280	lysine exporter protein (LysE YggA)
H3V39_RS27050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H3V39_RS27055	COG3046	protein related to deoxyribodipyrimidine photolyase
H3V39_RS27085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS27090	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS27100	COG0586	Pfam SNARE associated Golgi protein
H3V39_RS27105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3V39_RS27110	COG1349	DNA-binding transcription factor activity
H3V39_RS27115	COG1799	cell septum assembly
H3V39_RS27135	COG2040	homocysteine
H3V39_RS27155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3V39_RS27160	COG0531	amino acid
H3V39_RS27170	COG1024	Enoyl-CoA hydratase
H3V39_RS27210	COG2111	Na H antiporter
H3V39_RS27210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H3V39_RS27215	COG1006	Multisubunit Na H antiporter MnhC subunit
H3V39_RS27220	COG0651	ATP synthesis coupled electron transport
H3V39_RS27235	COG1320	monovalent cation:proton antiporter activity
H3V39_RS27250	COG0297	glycogen (starch) synthase activity
H3V39_RS27255	COG0489	protein tyrosine kinase activity
H3V39_RS27290	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H3V39_RS27295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H3V39_RS27300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3V39_RS27315	COG2197	response regulator
H3V39_RS27335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3V39_RS27375	COG0477	Major facilitator Superfamily
H3V39_RS27380	COG3629	intracellular signal transduction
H3V39_RS27380	COG3903	Transcriptional regulator
H3V39_RS27395	COG0300	oxidoreductase activity
H3V39_RS27405	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS27430	COG0475	glutathione-regulated potassium exporter activity
H3V39_RS27450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS27485	COG1228	amidohydrolase
H3V39_RS27540	COG3415	Transposase
H3V39_RS27540	COG2801	Transposase and inactivated derivatives
H3V39_RS27545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS27550	COG2376	Dihydroxyacetone kinase
H3V39_RS27555	COG2376	Dihydroxyacetone kinase
H3V39_RS27565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H3V39_RS27595	COG1196	nuclear chromosome segregation
H3V39_RS27615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H3V39_RS27620	COG0494	nUDIX hydrolase
H3V39_RS27625	COG0494	nUDIX hydrolase
H3V39_RS27640	COG0588	phosphoglycerate mutase activity
H3V39_RS27650	COG1653	transport
H3V39_RS27655	COG1175	transmembrane transport
H3V39_RS27660	COG0395	ABC-type sugar transport system, permease component
H3V39_RS27665	COG1940	carbohydrate kinase activity
H3V39_RS27670	COG4213	ABC transporter substrate-binding protein
H3V39_RS27680	COG4214	carbohydrate transport
H3V39_RS27685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H3V39_RS27690	COG0531	amino acid
H3V39_RS27715	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS27730	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS27730	COG1024	Enoyl-CoA hydratase
H3V39_RS27735	COG0183	Belongs to the thiolase family
H3V39_RS27760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H3V39_RS27775	COG0745	RESPONSE REGULATOR receiver
H3V39_RS27780	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3V39_RS27790	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H3V39_RS27795	COG3253	May function as heme-dependent peroxidase
H3V39_RS27810	COG3220	belongs to the UPF0276 family
H3V39_RS27825	COG4152	abc transporter atp-binding protein
H3V39_RS27845	COG2272	Belongs to the type-B carboxylesterase lipase family
H3V39_RS27895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H3V39_RS27900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3V39_RS27990	COG1063	alcohol dehydrogenase
H3V39_RS27995	COG0156	8-amino-7-oxononanoate synthase activity
H3V39_RS28000	COG0583	DNA-binding transcription factor activity
H3V39_RS28010	COG0346	lactoylglutathione lyase activity
H3V39_RS28015	COG1072	(Pantothenic acid kinase))
H3V39_RS28035	COG2723	6-phospho-beta-galactosidase activity
H3V39_RS28090	COG1175	transmembrane transport
H3V39_RS28110	COG1404	Belongs to the peptidase S8 family
H3V39_RS28130	COG1132	(ABC) transporter
H3V39_RS28135	COG1132	(ABC) transporter
H3V39_RS28140	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H3V39_RS28145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS28150	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS28155	COG1120	ATPase activity
H3V39_RS28160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H3V39_RS28175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3V39_RS28180	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H3V39_RS28200	COG0529	Catalyzes the synthesis of activated sulfate
H3V39_RS28205	COG0175	sulfate reduction
H3V39_RS28240	COG3844	kynureninase activity
H3V39_RS28245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H3V39_RS28260	COG1917	Cupin 2, conserved barrel domain protein
H3V39_RS28285	COG0583	DNA-binding transcription factor activity
H3V39_RS28310	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS28315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H3V39_RS28320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H3V39_RS28325	COG0583	DNA-binding transcription factor activity
H3V39_RS28330	COG0183	Belongs to the thiolase family
H3V39_RS28380	COG1162	GTPase activity
H3V39_RS28400	COG1404	Belongs to the peptidase S8 family
H3V39_RS28410	COG0028	Belongs to the TPP enzyme family
H3V39_RS28430	COG1802	Transcriptional regulator
H3V39_RS28455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H3V39_RS28460	COG2252	PERMEase
H3V39_RS28465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H3V39_RS28465	COG3608	succinylglutamate desuccinylase aspartoacylase
H3V39_RS28490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS28520	COG0435	Glutathione S-transferase
H3V39_RS28535	COG2197	response regulator
H3V39_RS28540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3V39_RS28545	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS28565	COG3960	tartronate-semialdehyde synthase activity
H3V39_RS28590	COG0753	catalase activity
H3V39_RS28595	COG2084	Dehydrogenase
H3V39_RS28600	COG3622	Belongs to the hyi family
H3V39_RS28605	COG2706	6-phosphogluconolactonase activity
H3V39_RS28625	COG2351	hydroxyisourate hydrolase activity
H3V39_RS28635	COG2233	PERMEase
H3V39_RS28645	COG2233	PERMEase
H3V39_RS28670	COG1288	antiporter activity
H3V39_RS28700	COG0242	peptide deformylase activity
H3V39_RS28705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H3V39_RS28720	COG2197	response regulator
H3V39_RS28740	COG1414	Transcriptional regulator
H3V39_RS28745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3V39_RS28750	COG4266	Belongs to the allantoicase family
H3V39_RS28760	COG0656	L-ascorbic acid biosynthetic process
H3V39_RS28765	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS28785	COG2197	response regulator
H3V39_RS28800	COG0673	inositol 2-dehydrogenase activity
H3V39_RS28805	COG2188	Transcriptional regulator
H3V39_RS28820	COG1129	ABC transporter
H3V39_RS28825	COG1940	carbohydrate kinase activity
H3V39_RS28835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3V39_RS28840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H3V39_RS28870	COG1126	abc transporter atp-binding protein
H3V39_RS28875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3V39_RS28880	COG0765	amino acid transport
H3V39_RS28885	COG0765	amino acid transport
H3V39_RS28900	COG1024	Enoyl-CoA hydratase
H3V39_RS28900	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS28905	COG0183	Belongs to the thiolase family
H3V39_RS28925	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS28935	COG1309	transcriptional regulator
H3V39_RS28940	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS28945	COG0405	Gamma-glutamyltransferase
H3V39_RS28980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3V39_RS29075	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS29095	COG1215	transferase activity, transferring glycosyl groups
H3V39_RS29105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H3V39_RS29120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS29135	COG0175	sulfate reduction
H3V39_RS29140	COG2895	sulfate adenylyltransferase (ATP) activity
H3V39_RS29185	COG0626	cystathionine gamma-synthase activity
H3V39_RS29200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS29275	COG1024	Enoyl-CoA hydratase
H3V39_RS29280	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS29300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H3V39_RS29315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H3V39_RS29360	COG1024	Enoyl-CoA hydratase
H3V39_RS29365	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS29395	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS29400	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS29405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3V39_RS29410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3V39_RS29420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS29430	COG1131	(ABC) transporter
H3V39_RS29435	COG1024	Enoyl-CoA hydratase
H3V39_RS29445	COG0483	inositol monophosphate 1-phosphatase activity
H3V39_RS29470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3V39_RS29500	COG1929	Belongs to the glycerate kinase type-1 family
H3V39_RS29535	COG0688	phosphatidylethanolamine metabolic process
H3V39_RS29540	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS29550	COG2301	Belongs to the HpcH HpaI aldolase family
H3V39_RS29555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3V39_RS29555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3V39_RS29560	COG0604	alcohol dehydrogenase
H3V39_RS29580	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS29590	COG0596	Alpha beta hydrolase
H3V39_RS29620	COG0583	DNA-binding transcription factor activity
H3V39_RS29625	COG0667	Aldo Keto reductase
H3V39_RS29645	COG2362	D-Aminopeptidase
H3V39_RS29650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3V39_RS29660	COG1619	proteins homologs of microcin C7 resistance protein MccF
H3V39_RS29715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3V39_RS29730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3V39_RS29730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H3V39_RS29740	COG2154	pterin-4-alpha-carbinolamine dehydratase
H3V39_RS29750	COG0702	epimerase
H3V39_RS29760	COG4106	trans-aconitate 2-methyltransferase activity
H3V39_RS29765	COG0300	oxidoreductase activity
H3V39_RS29795	COG0656	L-ascorbic acid biosynthetic process
H3V39_RS29810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H3V39_RS29815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3V39_RS29825	COG1129	ABC transporter
H3V39_RS29830	COG1172	Belongs to the binding-protein-dependent transport system permease family
H3V39_RS29835	COG1879	ABC-type sugar transport system periplasmic component
H3V39_RS29840	COG0673	inositol 2-dehydrogenase activity
H3V39_RS29860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H3V39_RS29875	COG0084	hydrolase, TatD family'
H3V39_RS29985	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS29985	COG3321	synthase
H3V39_RS29985	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS29985	COG0300	oxidoreductase activity
H3V39_RS29985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS29990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H3V39_RS30005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS30010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS30015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS30015	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H3V39_RS30015	COG3321	synthase
H3V39_RS30035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS30045	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS30070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3V39_RS30075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS30080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H3V39_RS30085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H3V39_RS30090	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS30110	COG0477	Major facilitator Superfamily
H3V39_RS30115	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS30130	COG1879	ABC-type sugar transport system periplasmic component
H3V39_RS30135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3V39_RS30140	COG1869	D-ribose catabolic process
H3V39_RS30150	COG0714	Associated with various cellular activities
H3V39_RS30165	COG3568	Endonuclease Exonuclease Phosphatase
H3V39_RS30180	COG5002	protein histidine kinase activity
H3V39_RS30185	COG0745	RESPONSE REGULATOR receiver
H3V39_RS30210	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS30220	COG0517	IMP dehydrogenase activity
H3V39_RS30220	COG4175	Glycine betaine
H3V39_RS30225	COG4176	ABC-type proline glycine betaine transport system permease component
H3V39_RS30265	COG0488	(ABC) transporter
H3V39_RS30275	COG1070	Carbohydrate kinase
H3V39_RS30285	COG1940	carbohydrate kinase activity
H3V39_RS30335	COG2124	cytochrome p450
H3V39_RS30340	COG1486	melibiose metabolic process
H3V39_RS30370	COG3012	SEC-C Motif Domain Protein
H3V39_RS30390	COG2860	membrane
H3V39_RS30395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H3V39_RS30395	COG1473	amidohydrolase
H3V39_RS30405	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS30450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H3V39_RS30475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H3V39_RS30515	COG2326	polyphosphate kinase activity
H3V39_RS30520	COG1793	dna ligase
H3V39_RS30570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3V39_RS30585	COG0488	(ABC) transporter
H3V39_RS30610	COG1515	deoxyribonuclease V activity
H3V39_RS30620	COG3268	Saccharopine dehydrogenase
H3V39_RS30625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H3V39_RS30630	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS30635	COG0183	Belongs to the thiolase family
H3V39_RS30640	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3V39_RS30640	COG1024	Enoyl-CoA hydratase
H3V39_RS30645	COG0789	Transcriptional regulator
H3V39_RS30670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H3V39_RS30685	COG0488	(ABC) transporter
H3V39_RS30690	COG2226	methyltransferase
H3V39_RS30705	COG4977	sequence-specific DNA binding
H3V39_RS30715	COG1024	Enoyl-CoA hydratase
H3V39_RS30730	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H3V39_RS30760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H3V39_RS30780	COG1134	teichoic acid transport
H3V39_RS30785	COG1562	ergosterol biosynthetic process
H3V39_RS30795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H3V39_RS30805	COG1657	PFAM Prenyltransferase squalene oxidase
H3V39_RS30845	COG2755	lipolytic protein G-D-S-L family
H3V39_RS30855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H3V39_RS30895	COG3467	pyridoxamine 5'-phosphate
H3V39_RS30905	COG0789	Transcriptional regulator
H3V39_RS30960	COG3958	Transketolase
H3V39_RS30965	COG3959	Transketolase, thiamine diphosphate binding domain
H3V39_RS30975	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS30985	COG1733	regulation of RNA biosynthetic process
H3V39_RS30995	COG0789	Transcriptional regulator
H3V39_RS31015	COG3511	phospholipase C
H3V39_RS31025	COG2197	response regulator
H3V39_RS31030	COG3851	Histidine kinase
H3V39_RS31065	COG2197	response regulator
H3V39_RS31095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS31100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3V39_RS31105	COG2423	ornithine cyclodeaminase activity
H3V39_RS31110	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS31115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS31150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H3V39_RS31165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS31190	COG1280	lysine exporter protein (LysE YggA)
H3V39_RS31245	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3V39_RS31245	COG1902	pentaerythritol trinitrate reductase activity
H3V39_RS31255	COG2409	Drug exporters of the RND superfamily
H3V39_RS31260	COG1846	Transcriptional regulator
H3V39_RS31310	COG2130	NADP-dependent
H3V39_RS31320	COG4948	Mandelate Racemase Muconate Lactonizing
H3V39_RS31325	COG0395	ABC-type sugar transport system, permease component
H3V39_RS31330	COG1175	transmembrane transport
H3V39_RS31345	COG2226	methyltransferase
H3V39_RS31365	COG3647	Membrane
H3V39_RS31370	COG2188	Transcriptional regulator
H3V39_RS31375	COG1742	UPF0060 membrane protein
H3V39_RS31390	COG1794	racemase activity, acting on amino acids and derivatives
H3V39_RS31430	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H3V39_RS31440	COG0019	diaminopimelate decarboxylase activity
H3V39_RS31445	COG2837	iron assimilation
H3V39_RS31450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H3V39_RS31465	COG1119	ATPase activity
H3V39_RS31475	COG1595	DNA-templated transcription, initiation
H3V39_RS31510	COG0596	Alpha beta hydrolase
H3V39_RS31520	COG1028	Short-chain dehydrogenase reductase Sdr
H3V39_RS31530	COG1652	LysM domain
H3V39_RS31555	COG2208	phosphoserine phosphatase activity
H3V39_RS31565	COG0784	Response regulator, receiver
H3V39_RS31570	COG4251	negative regulation of phosphorylation
H3V39_RS31575	COG2201	protein-glutamate methylesterase activity
H3V39_RS31580	COG1191	sigma factor activity
H3V39_RS31620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3V39_RS31635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H3V39_RS31640	COG3275	phosphorelay sensor kinase activity
H3V39_RS31715	COG0583	DNA-binding transcription factor activity
H3V39_RS31725	COG1053	succinate dehydrogenase
H3V39_RS31730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H3V39_RS31740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3V39_RS31750	COG3360	Dodecin
H3V39_RS31755	COG1653	transport
H3V39_RS31770	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H3V39_RS31775	COG0121	glutamine amidotransferase
H3V39_RS31780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H3V39_RS31800	COG1609	Transcriptional regulator
H3V39_RS31810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3V39_RS31815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3V39_RS31850	COG0714	Associated with various cellular activities
H3V39_RS31870	COG1191	sigma factor activity
H3V39_RS31880	COG2045	Belongs to the ComB family
H3V39_RS31885	COG1834	amidinotransferase
H3V39_RS31895	COG1228	amidohydrolase
H3V39_RS31900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H3V39_RS31915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H3V39_RS31995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H3V39_RS32015	COG0463	Glycosyl transferase, family 2
H3V39_RS32085	COG0477	Major facilitator Superfamily
H3V39_RS32095	COG0254	rRNA binding
H3V39_RS32100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3V39_RS32105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H3V39_RS32110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H3V39_RS32125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS32130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS32135	COG1120	ATPase activity
H3V39_RS32165	COG1132	(ABC) transporter
H3V39_RS32190	COG2304	oxidoreductase activity
H3V39_RS32210	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS32215	COG0726	polysaccharide deacetylase
H3V39_RS32220	COG0728	peptidoglycan biosynthetic process
H3V39_RS32235	COG0438	transferase activity, transferring glycosyl groups
H3V39_RS32235	COG0297	glycogen (starch) synthase activity
H3V39_RS32250	COG1174	glycine betaine transport
H3V39_RS32255	COG1174	glycine betaine transport
H3V39_RS32270	COG1125	glycine betaine transport
H3V39_RS32270	COG0517	IMP dehydrogenase activity
H3V39_RS32300	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS32305	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS32320	COG0601	transmembrane transport
H3V39_RS32325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3V39_RS32330	COG0444	Belongs to the ABC transporter superfamily
H3V39_RS32430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H3V39_RS32430	COG1796	DNA polymerase
H3V39_RS32490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3V39_RS32515	COG1278	Cold shock
H3V39_RS32520	COG0477	Major facilitator Superfamily
H3V39_RS32535	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H3V39_RS32540	COG0693	protein deglycase activity
H3V39_RS32555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS32560	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS32575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS32590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3V39_RS32600	COG0596	Alpha beta hydrolase
H3V39_RS32610	COG1132	(ABC) transporter
H3V39_RS32615	COG4044	May play a role in the intracellular transport of hydrophobic ligands
H3V39_RS32635	COG1063	alcohol dehydrogenase
H3V39_RS32655	COG1349	DNA-binding transcription factor activity
H3V39_RS32675	COG0789	Transcriptional regulator
H3V39_RS32680	COG1960	acyl-CoA dehydrogenase activity
H3V39_RS32700	COG1012	belongs to the aldehyde dehydrogenase family
H3V39_RS32760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H3V39_RS32800	COG0640	Transcriptional regulator
H3V39_RS32815	COG2018	Roadblock/LC7 domain
H3V39_RS32825	COG0456	acetyltransferase
H3V39_RS32840	COG1024	Enoyl-CoA hydratase
H3V39_RS32855	COG1357	PFAM Pentapeptide repeats (8 copies)
H3V39_RS32865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H3V39_RS32875	COG2340	Cysteine-rich secretory protein family
H3V39_RS32915	COG0488	(ABC) transporter
H3V39_RS32935	COG0009	L-threonylcarbamoyladenylate synthase
H3V39_RS32960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H3V39_RS32975	COG2318	DinB family
H3V39_RS32985	COG1609	Transcriptional regulator
H3V39_RS33000	COG0395	ABC-type sugar transport system, permease component
H3V39_RS33005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3V39_RS33010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS33020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3V39_RS33030	COG0714	Associated with various cellular activities
H3V39_RS33035	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H3V39_RS33065	COG2205	protein histidine kinase activity
H3V39_RS33070	COG0745	RESPONSE REGULATOR receiver
H3V39_RS33085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3V39_RS33090	COG1120	ATPase activity
H3V39_RS33105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H3V39_RS33160	COG0586	Pfam SNARE associated Golgi protein
H3V39_RS33175	COG2226	methyltransferase
H3V39_RS33180	COG0745	RESPONSE REGULATOR receiver
H3V39_RS33185	COG2205	protein histidine kinase activity
H3V39_RS33195	COG1404	Belongs to the peptidase S8 family
H3V39_RS33220	COG1595	DNA-templated transcription, initiation
H3V39_RS33230	COG0831	urea catabolic process
H3V39_RS33235	COG0832	Belongs to the urease beta subunit family
H3V39_RS33245	COG0830	nickel cation binding
H3V39_RS33250	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H3V39_RS33255	COG0829	nickel cation binding
H3V39_RS33265	COG4214	carbohydrate transport
H3V39_RS33275	COG4213	ABC transporter substrate-binding protein
H3V39_RS33285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H3V39_RS33290	COG0406	alpha-ribazole phosphatase activity
H3V39_RS33300	COG1070	Carbohydrate kinase
H3V39_RS33355	COG0395	ABC-type sugar transport system, permease component
H3V39_RS33380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS33405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H3V39_RS33430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H3V39_RS33450	COG0312	modulator of DNA gyrase
H3V39_RS33475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3V39_RS33495	COG0590	tRNA wobble adenosine to inosine editing
H3V39_RS33510	COG0583	DNA-binding transcription factor activity
H3V39_RS33640	COG0484	heat shock protein binding
H3V39_RS33650	COG1191	sigma factor activity
H3V39_RS33710	COG2860	membrane
H3V39_RS33720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H3V39_RS33775	COG0484	heat shock protein binding
H3V39_RS33820	COG4264	IucA IucC family
H3V39_RS33830	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H3V39_RS33855	COG0720	synthase
H3V39_RS33870	COG0302	gtp cyclohydrolase
H3V39_RS33885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3V39_RS33890	COG1733	regulation of RNA biosynthetic process
H3V39_RS33905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H3V39_RS33910	COG1518	maintenance of DNA repeat elements
H3V39_RS34215	COG1192	Involved in chromosome partitioning
H3V39_RS34245	COG0587	DNA-directed DNA polymerase activity
H3V39_RS34250	COG0596	Alpha beta hydrolase
H3V39_RS34260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H3V39_RS34275	COG1024	Enoyl-CoA hydratase
H3V39_RS34280	COG0456	acetyltransferase
H3V39_RS34285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS34295	COG0318	PFAM AMP-dependent synthetase and ligase
H3V39_RS34300	COG0019	diaminopimelate decarboxylase activity
H3V39_RS34305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3V39_RS34325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H3V39_RS34335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H3V39_RS34340	COG1280	lysine exporter protein (LysE YggA)