locus-tag	class	description
CFP59_RS00030	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS00040	COG0604	alcohol dehydrogenase
CFP59_RS00040	COG3321	synthase
CFP59_RS00050	COG3226	Transcriptional regulator
CFP59_RS00100	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS00120	COG1846	Transcriptional regulator
CFP59_RS00130	COG2826	transposase and inactivated derivatives, IS30 family
CFP59_RS00135	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS00180	COG0494	nUDIX hydrolase
CFP59_RS00210	COG0489	protein tyrosine kinase activity
CFP59_RS00215	COG2814	Major facilitator Superfamily
CFP59_RS00300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS00375	COG2801	Transposase and inactivated derivatives
CFP59_RS00405	COG3548	integral membrane protein
CFP59_RS00410	COG2186	Transcriptional regulator
CFP59_RS00415	COG1129	ABC transporter
CFP59_RS00440	COG3469	chitinase activity
CFP59_RS00465	COG0473	3-isopropylmalate dehydrogenase activity
CFP59_RS00465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CFP59_RS00470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS00480	COG0574	Belongs to the PEP-utilizing enzyme family
CFP59_RS00480	COG3848	Pyruvate phosphate dikinase
CFP59_RS00495	COG0142	geranyltranstransferase activity
CFP59_RS00525	COG0596	Alpha beta hydrolase
CFP59_RS00565	COG0667	Aldo Keto reductase
CFP59_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS00590	COG1136	(ABC) transporter
CFP59_RS00600	COG4585	Histidine kinase
CFP59_RS00605	COG2197	response regulator
CFP59_RS00630	COG1802	Transcriptional regulator
CFP59_RS00635	COG0006	proline dipeptidase activity
CFP59_RS00660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFP59_RS00665	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CFP59_RS00695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS00710	COG2175	clavaminate synthase activity
CFP59_RS00720	COG3246	L-lysine catabolic process to acetate
CFP59_RS00735	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS00800	COG4977	sequence-specific DNA binding
CFP59_RS00815	COG0596	Alpha beta hydrolase
CFP59_RS00850	COG3384	dioxygenase
CFP59_RS00895	COG0596	Alpha beta hydrolase
CFP59_RS00910	COG1309	transcriptional regulator
CFP59_RS00925	COG1309	transcriptional regulator
CFP59_RS00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS00960	COG1846	Transcriptional regulator
CFP59_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS00985	COG2801	Transposase and inactivated derivatives
CFP59_RS01015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFP59_RS01070	COG0436	Aminotransferase
CFP59_RS01080	COG2910	NAD(P)H-binding
CFP59_RS01090	COG0667	Aldo Keto reductase
CFP59_RS01110	COG1840	ABC-type Fe3 transport system, periplasmic component
CFP59_RS01115	COG1178	ABC-type Fe3 transport system permease component
CFP59_RS01125	COG0477	Major facilitator Superfamily
CFP59_RS01135	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CFP59_RS01155	COG2267	carboxylic ester hydrolase activity
CFP59_RS01165	COG2146	nitrite reductase [NAD(P)H] activity
CFP59_RS01170	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CFP59_RS01180	COG0346	lactoylglutathione lyase activity
CFP59_RS01185	COG1309	transcriptional regulator
CFP59_RS01240	COG2755	lipolytic protein G-D-S-L family
CFP59_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS01275	COG0747	negative chemotaxis
CFP59_RS01285	COG2271	Major facilitator Superfamily
CFP59_RS01290	COG0667	Aldo Keto reductase
CFP59_RS01295	COG0667	Aldo Keto reductase
CFP59_RS01345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFP59_RS01450	COG1309	transcriptional regulator
CFP59_RS01475	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CFP59_RS01510	COG0300	oxidoreductase activity
CFP59_RS01520	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS01525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CFP59_RS01530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS01535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFP59_RS01590	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS01595	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS01605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFP59_RS01610	COG0066	3-isopropylmalate dehydratase activity
CFP59_RS01630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFP59_RS01640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CFP59_RS01655	COG1902	pentaerythritol trinitrate reductase activity
CFP59_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFP59_RS01675	COG0596	Alpha beta hydrolase
CFP59_RS01700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CFP59_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS01730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFP59_RS01740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS01760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFP59_RS01775	COG0367	asparagine synthase
CFP59_RS01785	COG3903	Transcriptional regulator
CFP59_RS01785	COG3629	intracellular signal transduction
CFP59_RS01820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFP59_RS01825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFP59_RS01830	COG0436	Aminotransferase
CFP59_RS01845	COG0604	alcohol dehydrogenase
CFP59_RS01845	COG3321	synthase
CFP59_RS01845	COG0604	alcohol dehydrogenase
CFP59_RS01845	COG3321	synthase
CFP59_RS01855	COG0604	alcohol dehydrogenase
CFP59_RS01855	COG3321	synthase
CFP59_RS01855	COG0604	alcohol dehydrogenase
CFP59_RS01855	COG3321	synthase
CFP59_RS01860	COG2423	ornithine cyclodeaminase activity
CFP59_RS01865	COG0251	oxidation-reduction process
CFP59_RS01890	COG0714	Associated with various cellular activities
CFP59_RS01905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFP59_RS01905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CFP59_RS01930	COG2267	carboxylic ester hydrolase activity
CFP59_RS01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS01950	COG0601	transmembrane transport
CFP59_RS01955	COG0747	negative chemotaxis
CFP59_RS01960	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS01965	COG1309	transcriptional regulator
CFP59_RS01975	COG2249	NAD(P)H dehydrogenase (quinone) activity
CFP59_RS01985	COG0492	ferredoxin-NADP+ reductase activity
CFP59_RS02000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFP59_RS02010	COG0730	response to heat
CFP59_RS02020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS02030	COG0604	alcohol dehydrogenase
CFP59_RS02035	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFP59_RS02050	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS02065	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS02085	COG0604	alcohol dehydrogenase
CFP59_RS02120	COG0494	nUDIX hydrolase
CFP59_RS02120	COG0406	alpha-ribazole phosphatase activity
CFP59_RS02135	COG3842	ATPase activity
CFP59_RS02155	COG2188	Transcriptional regulator
CFP59_RS02165	COG3511	phospholipase C
CFP59_RS02175	COG3511	phospholipase C
CFP59_RS02185	COG1609	Transcriptional regulator
CFP59_RS02195	COG1653	transport
CFP59_RS02225	COG0154	amidase activity
CFP59_RS02245	COG0583	DNA-binding transcription factor activity
CFP59_RS02250	COG4214	carbohydrate transport
CFP59_RS02255	COG1129	ABC transporter
CFP59_RS02275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS02295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS02300	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS02325	COG4221	oxidoreductase activity
CFP59_RS02340	COG1414	Transcriptional regulator
CFP59_RS02355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFP59_RS02415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS02430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFP59_RS02450	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CFP59_RS02450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS02470	COG1595	DNA-templated transcription, initiation
CFP59_RS02520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CFP59_RS02525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFP59_RS02530	COG0657	acetylesterase activity
CFP59_RS02535	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS02560	COG0148	phosphopyruvate hydratase activity
CFP59_RS02570	COG0215	cysteine-tRNA ligase activity
CFP59_RS02575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFP59_RS02585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFP59_RS02590	COG2207	Transcriptional regulator
CFP59_RS02595	COG0667	Aldo Keto reductase
CFP59_RS02600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CFP59_RS02660	COG1121	(ABC) transporter
CFP59_RS02670	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFP59_RS02680	COG1120	ATPase activity
CFP59_RS02685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS02700	COG5492	domain, Protein
CFP59_RS02705	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CFP59_RS02710	COG0395	ABC-type sugar transport system, permease component
CFP59_RS02715	COG1175	transmembrane transport
CFP59_RS02780	COG0667	Aldo Keto reductase
CFP59_RS02805	COG1653	transport
CFP59_RS02825	COG2318	DinB family
CFP59_RS02865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS02870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS02875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS02880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFP59_RS02885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFP59_RS02895	COG2423	ornithine cyclodeaminase activity
CFP59_RS02910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFP59_RS02985	COG1609	Transcriptional regulator
CFP59_RS02990	COG0434	BtpA family
CFP59_RS03005	COG1129	ABC transporter
CFP59_RS03010	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS03035	COG2186	Transcriptional regulator
CFP59_RS03045	COG0765	amino acid transport
CFP59_RS03070	COG1802	Transcriptional regulator
CFP59_RS03085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS03100	COG1914	H( )-stimulated, divalent metal cation uptake system
CFP59_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS03115	COG1309	transcriptional regulator
CFP59_RS03130	COG0277	FAD linked oxidase domain protein
CFP59_RS03135	COG0402	S-adenosylhomocysteine deaminase activity
CFP59_RS03150	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFP59_RS03205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS03210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS03230	COG1126	abc transporter atp-binding protein
CFP59_RS03255	COG2130	NADP-dependent
CFP59_RS03260	COG0789	Transcriptional regulator
CFP59_RS03275	COG0477	Major facilitator Superfamily
CFP59_RS03290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS03295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS03300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS03320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS03385	COG0747	negative chemotaxis
CFP59_RS03390	COG0601	transmembrane transport
CFP59_RS03395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS03405	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS03410	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS03430	COG1116	anion transmembrane transporter activity
CFP59_RS03440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS03450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS03455	COG0583	DNA-binding transcription factor activity
CFP59_RS03460	COG0745	RESPONSE REGULATOR receiver
CFP59_RS03470	COG1136	(ABC) transporter
CFP59_RS03475	COG1136	(ABC) transporter
CFP59_RS03485	COG5002	protein histidine kinase activity
CFP59_RS03510	COG0583	DNA-binding transcription factor activity
CFP59_RS03525	COG1802	Transcriptional regulator
CFP59_RS03535	COG1228	amidohydrolase
CFP59_RS03550	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS03555	COG1129	ABC transporter
CFP59_RS03565	COG1609	Transcriptional regulator
CFP59_RS03575	COG1175	transmembrane transport
CFP59_RS03580	COG0395	ABC-type sugar transport system, permease component
CFP59_RS03590	COG3938	Belongs to the proline racemase family
CFP59_RS03595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS03620	COG1070	Carbohydrate kinase
CFP59_RS03625	COG2188	Transcriptional regulator
CFP59_RS03630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS03635	COG0028	Belongs to the TPP enzyme family
CFP59_RS03645	COG0477	Major facilitator Superfamily
CFP59_RS03655	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CFP59_RS03655	COG3261	NADH dehydrogenase
CFP59_RS03660	COG0651	ATP synthesis coupled electron transport
CFP59_RS03670	COG0650	Formate hydrogenlyase subunit 4
CFP59_RS03680	COG3260	NADH ubiquinone oxidoreductase 20
CFP59_RS03710	COG1595	DNA-templated transcription, initiation
CFP59_RS03730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFP59_RS03745	COG4221	oxidoreductase activity
CFP59_RS03755	COG1595	DNA-templated transcription, initiation
CFP59_RS03780	COG0456	acetyltransferase
CFP59_RS03785	COG1891	lyase activity
CFP59_RS03795	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFP59_RS03805	COG3250	beta-galactosidase activity
CFP59_RS03825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFP59_RS03830	COG1116	anion transmembrane transporter activity
CFP59_RS03835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS03840	COG2186	Transcriptional regulator
CFP59_RS03845	COG0395	ABC-type sugar transport system, permease component
CFP59_RS03850	COG1175	transmembrane transport
CFP59_RS03875	COG2084	Dehydrogenase
CFP59_RS03880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CFP59_RS03885	COG1063	alcohol dehydrogenase
CFP59_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS03910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFP59_RS03925	COG0477	Major facilitator Superfamily
CFP59_RS03940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFP59_RS03945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CFP59_RS03960	COG1309	transcriptional regulator
CFP59_RS03965	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS04015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFP59_RS04020	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS04025	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS04030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CFP59_RS04035	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS04040	COG1129	ABC transporter
CFP59_RS04050	COG1069	ribulokinase activity
CFP59_RS04055	COG1063	alcohol dehydrogenase
CFP59_RS04060	COG1879	ABC-type sugar transport system periplasmic component
CFP59_RS04070	COG2826	transposase and inactivated derivatives, IS30 family
CFP59_RS04085	COG0657	acetylesterase activity
CFP59_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS04115	COG1309	transcriptional regulator
CFP59_RS04120	COG0154	amidase activity
CFP59_RS04160	COG1349	DNA-binding transcription factor activity
CFP59_RS04165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CFP59_RS04185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS04190	COG0444	Belongs to the ABC transporter superfamily
CFP59_RS04195	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS04215	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS04225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS04255	COG1309	transcriptional regulator
CFP59_RS04265	COG1140	nitrate reductase beta subunit
CFP59_RS04270	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CFP59_RS04285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFP59_RS04285	COG1017	nitric oxide dioxygenase activity
CFP59_RS04305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFP59_RS04320	COG2382	esterase
CFP59_RS04325	COG1132	(ABC) transporter
CFP59_RS04335	COG1132	(ABC) transporter
CFP59_RS04340	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFP59_RS04345	COG1120	ATPase activity
CFP59_RS04350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS04355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS04360	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CFP59_RS04375	COG0583	DNA-binding transcription factor activity
CFP59_RS04385	COG2159	amidohydrolase
CFP59_RS04390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CFP59_RS04405	COG0698	ribose 5-phosphate isomerase
CFP59_RS04415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFP59_RS04435	COG0588	phosphoglycerate mutase activity
CFP59_RS04455	COG1840	ABC-type Fe3 transport system, periplasmic component
CFP59_RS04460	COG1178	ABC-type Fe3 transport system permease component
CFP59_RS04465	COG3842	ATPase activity
CFP59_RS04480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFP59_RS04490	COG2186	Transcriptional regulator
CFP59_RS04520	COG2315	Protein conserved in bacteria
CFP59_RS04535	COG0667	Aldo Keto reductase
CFP59_RS04540	COG1063	alcohol dehydrogenase
CFP59_RS04550	COG4221	oxidoreductase activity
CFP59_RS04560	COG2267	carboxylic ester hydrolase activity
CFP59_RS04575	COG1309	transcriptional regulator
CFP59_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS04585	COG2197	response regulator
CFP59_RS04590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFP59_RS04600	COG0165	Argininosuccinate lyase
CFP59_RS04635	COG2175	clavaminate synthase activity
CFP59_RS04650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS04670	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CFP59_RS04700	COG1024	Enoyl-CoA hydratase
CFP59_RS04705	COG1024	Enoyl-CoA hydratase
CFP59_RS04775	COG3424	synthase
CFP59_RS04780	COG1309	transcriptional regulator
CFP59_RS04790	COG2130	NADP-dependent
CFP59_RS04825	COG0601	transmembrane transport
CFP59_RS04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS04835	COG0444	Belongs to the ABC transporter superfamily
CFP59_RS04840	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS04865	COG0604	alcohol dehydrogenase
CFP59_RS04865	COG3321	synthase
CFP59_RS04870	COG0583	DNA-binding transcription factor activity
CFP59_RS04885	COG0475	glutathione-regulated potassium exporter activity
CFP59_RS04930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFP59_RS04950	COG0738	Major facilitator superfamily
CFP59_RS04955	COG3226	Transcriptional regulator
CFP59_RS04985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS04990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CFP59_RS04995	COG0745	RESPONSE REGULATOR receiver
CFP59_RS05025	COG2050	protein possibly involved in aromatic compounds catabolism
CFP59_RS05030	COG0154	amidase activity
CFP59_RS05060	COG0531	amino acid
CFP59_RS05165	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFP59_RS05175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFP59_RS05175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CFP59_RS05190	COG3345	alpha-galactosidase
CFP59_RS05195	COG1940	carbohydrate kinase activity
CFP59_RS05195	COG1846	Transcriptional regulator
CFP59_RS05205	COG0583	DNA-binding transcription factor activity
CFP59_RS05215	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS05225	COG1024	Enoyl-CoA hydratase
CFP59_RS05230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CFP59_RS05275	COG0477	Major facilitator Superfamily
CFP59_RS05290	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
CFP59_RS05295	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS05310	COG1454	alcohol dehydrogenase
CFP59_RS05320	COG4585	Histidine kinase
CFP59_RS05325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFP59_RS05365	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS05370	COG0574	Belongs to the PEP-utilizing enzyme family
CFP59_RS05370	COG3848	Pyruvate phosphate dikinase
CFP59_RS05390	COG0697	spore germination
CFP59_RS05420	COG1796	DNA polymerase
CFP59_RS05420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFP59_RS05435	COG0673	inositol 2-dehydrogenase activity
CFP59_RS05450	COG2814	Major facilitator Superfamily
CFP59_RS05465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFP59_RS05470	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS05475	COG0667	Aldo Keto reductase
CFP59_RS05495	COG0667	Aldo Keto reductase
CFP59_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFP59_RS05530	COG0765	amino acid transport
CFP59_RS05545	COG0586	Pfam SNARE associated Golgi protein
CFP59_RS05550	COG4585	Histidine kinase
CFP59_RS05555	COG2197	response regulator
CFP59_RS05560	COG2423	ornithine cyclodeaminase activity
CFP59_RS05580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS05590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS05625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS05675	COG1280	lysine exporter protein (LysE YggA)
CFP59_RS05695	COG0673	inositol 2-dehydrogenase activity
CFP59_RS05710	COG0367	asparagine synthase
CFP59_RS05745	COG4221	oxidoreductase activity
CFP59_RS05755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS05765	COG1397	ADP-ribosylglycohydrolase
CFP59_RS05770	COG2188	Transcriptional regulator
CFP59_RS05775	COG0596	Alpha beta hydrolase
CFP59_RS05800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFP59_RS05805	COG4166	transmembrane transport
CFP59_RS05810	COG0601	transmembrane transport
CFP59_RS05815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS05820	COG0444	Belongs to the ABC transporter superfamily
CFP59_RS05825	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS05860	COG0673	inositol 2-dehydrogenase activity
CFP59_RS05865	COG0673	inositol 2-dehydrogenase activity
CFP59_RS05875	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS05880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CFP59_RS05885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS05905	COG3708	Transcriptional regulator
CFP59_RS05905	COG2207	Transcriptional regulator
CFP59_RS05910	COG1113	amino acid transport
CFP59_RS05915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFP59_RS05930	COG3226	Transcriptional regulator
CFP59_RS05935	COG2391	methyltransferase activity
CFP59_RS05955	COG1733	regulation of RNA biosynthetic process
CFP59_RS05975	COG0604	alcohol dehydrogenase
CFP59_RS05975	COG3321	synthase
CFP59_RS05980	COG3321	synthase
CFP59_RS05980	COG0604	alcohol dehydrogenase
CFP59_RS06005	COG0604	alcohol dehydrogenase
CFP59_RS06005	COG3321	synthase
CFP59_RS06040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFP59_RS06145	COG3629	intracellular signal transduction
CFP59_RS06150	COG1132	(ABC) transporter
CFP59_RS06165	COG1132	(ABC) transporter
CFP59_RS06170	COG1132	(ABC) transporter
CFP59_RS06185	COG1946	Acyl-CoA thioesterase
CFP59_RS06195	COG2018	Roadblock/LC7 domain
CFP59_RS06235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFP59_RS06245	COG4677	pectinesterase activity
CFP59_RS06255	COG1070	Carbohydrate kinase
CFP59_RS06260	COG1940	carbohydrate kinase activity
CFP59_RS06275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFP59_RS06280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFP59_RS06290	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS06295	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS06305	COG3572	ergothioneine biosynthetic process
CFP59_RS06310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CFP59_RS06320	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CFP59_RS06330	COG3573	Dehydrogenase
CFP59_RS06335	COG2188	Transcriptional regulator
CFP59_RS06340	COG1309	transcriptional regulator
CFP59_RS06345	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS06380	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CFP59_RS06385	COG0298	carbon dioxide binding
CFP59_RS06395	COG0309	Hydrogenase expression formation protein (HypE)
CFP59_RS06405	COG2326	polyphosphate kinase activity
CFP59_RS06415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CFP59_RS06430	COG1017	nitric oxide dioxygenase activity
CFP59_RS06430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFP59_RS06435	COG0745	RESPONSE REGULATOR receiver
CFP59_RS06440	COG2205	protein histidine kinase activity
CFP59_RS06500	COG1024	Enoyl-CoA hydratase
CFP59_RS06530	COG3290	protein histidine kinase activity
CFP59_RS06555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFP59_RS06565	COG0531	amino acid
CFP59_RS06580	COG2340	Cysteine-rich secretory protein family
CFP59_RS06590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFP59_RS06635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFP59_RS06680	COG3383	formate dehydrogenase (NAD+) activity
CFP59_RS06680	COG0243	molybdopterin cofactor binding
CFP59_RS06685	COG0437	4 iron, 4 sulfur cluster binding
CFP59_RS06720	COG0464	growth
CFP59_RS06850	COG0246	Mannitol dehydrogenase
CFP59_RS06855	COG2271	Major facilitator Superfamily
CFP59_RS06860	COG1063	alcohol dehydrogenase
CFP59_RS06865	COG3012	SEC-C Motif Domain Protein
CFP59_RS06885	COG0477	Major facilitator Superfamily
CFP59_RS06920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CFP59_RS06935	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS06940	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CFP59_RS06945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS07040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS07120	COG0604	alcohol dehydrogenase
CFP59_RS07120	COG3321	synthase
CFP59_RS07125	COG3321	synthase
CFP59_RS07125	COG0604	alcohol dehydrogenase
CFP59_RS07130	COG3321	synthase
CFP59_RS07130	COG0604	alcohol dehydrogenase
CFP59_RS07150	COG3629	intracellular signal transduction
CFP59_RS07160	COG2936	dipeptidyl-peptidase activity
CFP59_RS07165	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFP59_RS07175	COG0542	response to heat
CFP59_RS07185	COG1595	DNA-templated transcription, initiation
CFP59_RS07190	COG1252	NADH dehydrogenase
CFP59_RS07195	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS07220	COG0384	phenazine biosynthesis protein PhzF
CFP59_RS07225	COG2313	pseudouridylate synthase activity
CFP59_RS07230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS07230	COG1522	sequence-specific DNA binding
CFP59_RS07270	COG3290	protein histidine kinase activity
CFP59_RS07280	COG0673	inositol 2-dehydrogenase activity
CFP59_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS07290	COG0604	alcohol dehydrogenase
CFP59_RS07290	COG3321	synthase
CFP59_RS07295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS07305	COG1834	amidinotransferase
CFP59_RS07310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFP59_RS07340	COG0477	Major facilitator Superfamily
CFP59_RS07345	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CFP59_RS07360	COG0443	Heat shock 70 kDa protein
CFP59_RS07390	COG1522	sequence-specific DNA binding
CFP59_RS07400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFP59_RS07405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS07420	COG0596	Alpha beta hydrolase
CFP59_RS07425	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS07430	COG1802	Transcriptional regulator
CFP59_RS07450	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS07475	COG3250	beta-galactosidase activity
CFP59_RS07485	COG1796	DNA polymerase
CFP59_RS07485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFP59_RS07510	COG2723	6-phospho-beta-galactosidase activity
CFP59_RS07515	COG0395	ABC-type sugar transport system, permease component
CFP59_RS07520	COG1175	transmembrane transport
CFP59_RS07525	COG2182	Extracellular solute-binding protein
CFP59_RS07555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CFP59_RS07560	COG1349	DNA-binding transcription factor activity
CFP59_RS07565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFP59_RS07570	COG0191	fructose-bisphosphate aldolase activity
CFP59_RS07620	COG0745	RESPONSE REGULATOR receiver
CFP59_RS07625	COG2205	protein histidine kinase activity
CFP59_RS07630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFP59_RS07640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFP59_RS07655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFP59_RS07695	COG0183	Belongs to the thiolase family
CFP59_RS07700	COG1309	transcriptional regulator
CFP59_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS07710	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS07715	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS07730	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS07735	COG1024	Enoyl-CoA hydratase
CFP59_RS07755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CFP59_RS07765	COG3360	Dodecin
CFP59_RS07780	COG3959	Transketolase, thiamine diphosphate binding domain
CFP59_RS07785	COG1252	NADH dehydrogenase
CFP59_RS07795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFP59_RS07815	COG0667	Aldo Keto reductase
CFP59_RS07825	COG2197	response regulator
CFP59_RS07830	COG4585	Histidine kinase
CFP59_RS07840	COG1131	(ABC) transporter
CFP59_RS07910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CFP59_RS07935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CFP59_RS08000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFP59_RS08010	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CFP59_RS08025	COG0110	maltose O-acetyltransferase activity
CFP59_RS08075	COG0671	phosphoesterase, PA-phosphatase related
CFP59_RS08085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFP59_RS08090	COG1733	regulation of RNA biosynthetic process
CFP59_RS08095	COG0477	Major facilitator Superfamily
CFP59_RS08125	COG0745	RESPONSE REGULATOR receiver
CFP59_RS08130	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS08150	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CFP59_RS08155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CFP59_RS08165	COG2133	pyrroloquinoline quinone binding
CFP59_RS08175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CFP59_RS08180	COG0174	glutamine synthetase
CFP59_RS08190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CFP59_RS08210	COG1064	alcohol dehydrogenase
CFP59_RS08220	COG2851	Citrate transporter
CFP59_RS08225	COG0583	DNA-binding transcription factor activity
CFP59_RS08230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS08240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFP59_RS08255	COG2197	response regulator
CFP59_RS08270	COG1595	DNA-templated transcription, initiation
CFP59_RS08280	COG0386	Belongs to the glutathione peroxidase family
CFP59_RS08290	COG2353	YceI-like domain
CFP59_RS08365	COG0395	ABC-type sugar transport system, permease component
CFP59_RS08370	COG1175	transmembrane transport
CFP59_RS08375	COG1653	transport
CFP59_RS08380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS08390	COG1486	melibiose metabolic process
CFP59_RS08400	COG1653	transport
CFP59_RS08410	COG0395	ABC-type sugar transport system, permease component
CFP59_RS08415	COG1063	alcohol dehydrogenase
CFP59_RS08435	COG0514	ATP-dependent DNA helicase (RecQ)
CFP59_RS08460	COG2186	Transcriptional regulator
CFP59_RS08505	COG0765	amino acid transport
CFP59_RS08510	COG1126	abc transporter atp-binding protein
CFP59_RS08530	COG0640	Transcriptional regulator
CFP59_RS08590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFP59_RS08600	COG0277	FAD linked oxidase domain protein
CFP59_RS08605	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CFP59_RS08630	COG1063	alcohol dehydrogenase
CFP59_RS08675	COG3250	beta-galactosidase activity
CFP59_RS08685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFP59_RS08735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFP59_RS08740	COG0395	ABC-type sugar transport system, permease component
CFP59_RS08765	COG3629	intracellular signal transduction
CFP59_RS08765	COG3903	Transcriptional regulator
CFP59_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS08835	COG0667	Aldo Keto reductase
CFP59_RS08840	COG3395	kinase activity
CFP59_RS08845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CFP59_RS08850	COG1349	DNA-binding transcription factor activity
CFP59_RS08855	COG1132	(ABC) transporter
CFP59_RS08880	COG1191	sigma factor activity
CFP59_RS08890	COG1793	dna ligase
CFP59_RS08905	COG0252	asparaginase activity
CFP59_RS08925	COG3631	Ketosteroid isomerase-related protein
CFP59_RS08930	COG0702	epimerase
CFP59_RS08975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFP59_RS08980	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS08990	COG0242	peptide deformylase activity
CFP59_RS09000	COG3442	glutamine amidotransferase
CFP59_RS09005	COG0205	6-phosphofructokinase activity
CFP59_RS09050	COG0829	nickel cation binding
CFP59_RS09055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CFP59_RS09065	COG0804	urea catabolic process
CFP59_RS09070	COG0832	Belongs to the urease beta subunit family
CFP59_RS09075	COG0831	urea catabolic process
CFP59_RS09080	COG4935	Belongs to the peptidase S8 family
CFP59_RS09080	COG2234	aminopeptidase activity
CFP59_RS09090	COG0740	serine-type endopeptidase activity
CFP59_RS09100	COG0741	lytic transglycosylase activity
CFP59_RS09100	COG0791	NLP P60 protein
CFP59_RS09130	COG0156	8-amino-7-oxononanoate synthase activity
CFP59_RS09135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFP59_RS09140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFP59_RS09145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CFP59_RS09150	COG2226	methyltransferase
CFP59_RS09155	COG1136	(ABC) transporter
CFP59_RS09155	COG0577	efflux transmembrane transporter activity
CFP59_RS09195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFP59_RS09210	COG2318	DinB family
CFP59_RS09230	COG0009	L-threonylcarbamoyladenylate synthase
CFP59_RS09240	COG1940	carbohydrate kinase activity
CFP59_RS09245	COG2188	Transcriptional regulator
CFP59_RS09275	COG0626	cystathionine gamma-synthase activity
CFP59_RS09290	COG0419	ATPase involved in DNA repair
CFP59_RS09300	COG0420	3'-5' exonuclease activity
CFP59_RS09305	COG1739	Uncharacterized protein family UPF0029
CFP59_RS09320	COG2814	Major facilitator Superfamily
CFP59_RS09335	COG0667	Aldo Keto reductase
CFP59_RS09370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFP59_RS09375	COG0028	Belongs to the TPP enzyme family
CFP59_RS09415	COG2066	Belongs to the glutaminase family
CFP59_RS09420	COG2267	carboxylic ester hydrolase activity
CFP59_RS09430	COG1335	isochorismatase
CFP59_RS09435	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS09445	COG1832	CoA-binding protein
CFP59_RS09510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFP59_RS09520	COG2814	Major facilitator Superfamily
CFP59_RS09525	COG1968	undecaprenyl-diphosphatase activity
CFP59_RS09535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFP59_RS09550	COG1070	Carbohydrate kinase
CFP59_RS09565	COG1175	transmembrane transport
CFP59_RS09570	COG0395	ABC-type sugar transport system, permease component
CFP59_RS09575	COG1609	Transcriptional regulator
CFP59_RS09595	COG3290	protein histidine kinase activity
CFP59_RS09600	COG4565	transcriptional regulatory protein
CFP59_RS09645	COG0583	DNA-binding transcription factor activity
CFP59_RS09655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS09660	COG0395	ABC-type sugar transport system, permease component
CFP59_RS09665	COG1175	transmembrane transport
CFP59_RS09685	COG2018	Roadblock/LC7 domain
CFP59_RS09690	COG0642	Histidine kinase
CFP59_RS09705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFP59_RS09825	COG0604	alcohol dehydrogenase
CFP59_RS09890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS09905	COG1472	Belongs to the glycosyl hydrolase 3 family
CFP59_RS09910	COG1874	Beta-galactosidase
CFP59_RS09920	COG0395	ABC-type sugar transport system, permease component
CFP59_RS09925	COG1175	transmembrane transport
CFP59_RS09955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFP59_RS09960	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CFP59_RS09970	COG2264	protein methyltransferase activity
CFP59_RS09980	COG0596	Alpha beta hydrolase
CFP59_RS10005	COG2072	flavoprotein involved in K transport
CFP59_RS10010	COG1609	Transcriptional regulator
CFP59_RS10015	COG1609	Transcriptional regulator
CFP59_RS10025	COG3254	rhamnose metabolic process
CFP59_RS10050	COG3250	beta-galactosidase activity
CFP59_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS10060	COG3347	Dehydrogenase
CFP59_RS10065	COG1070	Carbohydrate kinase
CFP59_RS10070	COG0247	lactate metabolic process
CFP59_RS10075	COG1139	Iron-sulfur cluster binding protein
CFP59_RS10080	COG1556	Lactate utilization protein
CFP59_RS10145	COG2186	Transcriptional regulator
CFP59_RS10175	COG0463	Glycosyl transferase, family 2
CFP59_RS10200	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS10225	COG5001	Diguanylate cyclase
CFP59_RS10225	COG3300	MHYT domain
CFP59_RS10270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFP59_RS10275	COG0140	phosphoribosyl-ATP diphosphatase activity
CFP59_RS10280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFP59_RS10285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFP59_RS10285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFP59_RS10305	COG1846	Transcriptional regulator
CFP59_RS10305	COG1940	carbohydrate kinase activity
CFP59_RS10310	COG0738	Major facilitator superfamily
CFP59_RS10320	COG2233	PERMEase
CFP59_RS10345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFP59_RS10355	COG0531	amino acid
CFP59_RS10390	COG0640	Transcriptional regulator
CFP59_RS10400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFP59_RS10405	COG2390	Transcriptional regulator
CFP59_RS10410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFP59_RS10425	COG1132	(ABC) transporter
CFP59_RS10430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFP59_RS10465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFP59_RS10480	COG0194	GDP metabolic process
CFP59_RS10490	COG0284	orotidine-5'-phosphate decarboxylase activity
CFP59_RS10495	COG0167	dihydroorotate dehydrogenase activity
CFP59_RS10500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFP59_RS10505	COG0505	Belongs to the CarA family
CFP59_RS10515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFP59_RS10520	COG0540	Belongs to the ATCase OTCase family
CFP59_RS10525	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFP59_RS10535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFP59_RS10540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFP59_RS10545	COG0006	proline dipeptidase activity
CFP59_RS10555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFP59_RS10560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CFP59_RS10565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFP59_RS10570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFP59_RS10580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFP59_RS10585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFP59_RS10600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFP59_RS10630	COG4585	Histidine kinase
CFP59_RS10635	COG2197	response regulator
CFP59_RS10640	COG0124	histidyl-tRNA synthetase
CFP59_RS10650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFP59_RS10655	COG1196	nuclear chromosome segregation
CFP59_RS10660	COG2826	transposase and inactivated derivatives, IS30 family
CFP59_RS10665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFP59_RS10670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFP59_RS10675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFP59_RS10680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFP59_RS10690	COG2255	four-way junction helicase activity
CFP59_RS10695	COG0632	four-way junction helicase activity
CFP59_RS10700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CFP59_RS10705	COG0217	transcriptional regulatory protein
CFP59_RS10710	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CFP59_RS10715	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CFP59_RS10725	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS10735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFP59_RS10755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFP59_RS10770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CFP59_RS10835	COG0512	Glutamine amidotransferase of anthranilate synthase
CFP59_RS10835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFP59_RS10890	COG1733	regulation of RNA biosynthetic process
CFP59_RS10960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS10990	COG1648	precorrin-2 dehydrogenase activity
CFP59_RS10990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CFP59_RS10995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CFP59_RS11010	COG1464	Belongs to the NlpA lipoprotein family
CFP59_RS11015	COG2011	ABC-type metal ion transport system permease component
CFP59_RS11060	COG0204	Acyl-transferase
CFP59_RS11060	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS11075	COG0165	Argininosuccinate lyase
CFP59_RS11080	COG0137	argininosuccinate synthase activity
CFP59_RS11110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFP59_RS11120	COG0583	DNA-binding transcription factor activity
CFP59_RS11130	COG0385	Bile acid
CFP59_RS11135	COG1438	arginine binding
CFP59_RS11140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFP59_RS11145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFP59_RS11150	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CFP59_RS11155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CFP59_RS11160	COG2838	Isocitrate dehydrogenase
CFP59_RS11175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFP59_RS11180	COG0697	spore germination
CFP59_RS11190	COG1649	PFAM Uncharacterised BCR, COG1649
CFP59_RS11210	COG2814	Major facilitator Superfamily
CFP59_RS11215	COG1285	pathogenesis
CFP59_RS11240	COG2860	membrane
CFP59_RS11255	COG0072	phenylalanine-tRNA ligase activity
CFP59_RS11255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFP59_RS11260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFP59_RS11265	COG5002	protein histidine kinase activity
CFP59_RS11270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFP59_RS11275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFP59_RS11280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFP59_RS11285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFP59_RS11295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFP59_RS11335	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS11350	COG0531	amino acid
CFP59_RS11355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CFP59_RS11360	COG0596	Alpha beta hydrolase
CFP59_RS11425	COG2755	lipolytic protein G-D-S-L family
CFP59_RS11430	COG2365	Tyrosine phosphatase family
CFP59_RS11445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CFP59_RS11450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CFP59_RS11465	COG1657	PFAM Prenyltransferase squalene oxidase
CFP59_RS11475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CFP59_RS11485	COG1562	ergosterol biosynthetic process
CFP59_RS11505	COG1134	teichoic acid transport
CFP59_RS11550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CFP59_RS11570	COG2183	response to ionizing radiation
CFP59_RS11585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CFP59_RS11595	COG2936	dipeptidyl-peptidase activity
CFP59_RS11600	COG0308	aminopeptidase N
CFP59_RS11610	COG3250	beta-galactosidase activity
CFP59_RS11625	COG0583	DNA-binding transcription factor activity
CFP59_RS11630	COG1024	Enoyl-CoA hydratase
CFP59_RS11630	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS11635	COG0183	Belongs to the thiolase family
CFP59_RS11640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS11650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS11745	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS11765	COG0431	NADPH-dependent FMN reductase
CFP59_RS11775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS11790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS11795	COG0601	transmembrane transport
CFP59_RS11880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CFP59_RS11885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CFP59_RS11890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CFP59_RS11905	COG1309	transcriptional regulator
CFP59_RS11920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFP59_RS11925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CFP59_RS11950	COG0583	DNA-binding transcription factor activity
CFP59_RS11955	COG0697	spore germination
CFP59_RS11965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CFP59_RS11975	COG2239	Acts as a magnesium transporter
CFP59_RS11990	COG0515	serine threonine protein kinase
CFP59_RS11990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFP59_RS12015	COG2271	Major facilitator Superfamily
CFP59_RS12020	COG1027	Aspartate ammonia-lyase
CFP59_RS12025	COG1414	Transcriptional regulator
CFP59_RS12030	COG1846	Transcriptional regulator
CFP59_RS12035	COG0697	spore germination
CFP59_RS12040	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CFP59_RS12050	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFP59_RS12050	COG0596	Alpha beta hydrolase
CFP59_RS12055	COG1309	transcriptional regulator
CFP59_RS12065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFP59_RS12075	COG0693	protein deglycase activity
CFP59_RS12095	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS12105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS12110	COG2188	Transcriptional regulator
CFP59_RS12115	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CFP59_RS12120	COG2814	Major facilitator Superfamily
CFP59_RS12125	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CFP59_RS12130	COG1920	GTP binding
CFP59_RS12165	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS12175	COG0045	succinate-CoA ligase (ADP-forming) activity
CFP59_RS12185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS12255	COG0673	inositol 2-dehydrogenase activity
CFP59_RS12260	COG1879	ABC-type sugar transport system periplasmic component
CFP59_RS12265	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS12270	COG1129	ABC transporter
CFP59_RS12275	COG1940	carbohydrate kinase activity
CFP59_RS12280	COG0222	ribosome binding
CFP59_RS12295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CFP59_RS12300	COG3383	formate dehydrogenase (NAD+) activity
CFP59_RS12315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CFP59_RS12320	COG1309	transcriptional regulator
CFP59_RS12330	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS12340	COG0789	Transcriptional regulator
CFP59_RS12360	COG0583	DNA-binding transcription factor activity
CFP59_RS12380	COG0656	L-ascorbic acid biosynthetic process
CFP59_RS12390	COG1595	DNA-templated transcription, initiation
CFP59_RS12405	COG2154	pterin-4-alpha-carbinolamine dehydratase
CFP59_RS12420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CFP59_RS12455	COG4214	carbohydrate transport
CFP59_RS12465	COG1879	ABC-type sugar transport system periplasmic component
CFP59_RS12490	COG2267	carboxylic ester hydrolase activity
CFP59_RS12505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CFP59_RS12540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFP59_RS12600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS12605	COG0028	Belongs to the TPP enzyme family
CFP59_RS12610	COG0693	protein deglycase activity
CFP59_RS12640	COG0517	IMP dehydrogenase activity
CFP59_RS12640	COG0617	tRNA 3'-terminal CCA addition
CFP59_RS12640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CFP59_RS12645	COG4106	trans-aconitate 2-methyltransferase activity
CFP59_RS12680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFP59_RS12685	COG2362	D-Aminopeptidase
CFP59_RS12695	COG2208	phosphoserine phosphatase activity
CFP59_RS12695	COG1366	Belongs to the anti-sigma-factor antagonist family
CFP59_RS12695	COG2172	sigma factor antagonist activity
CFP59_RS12725	COG1309	transcriptional regulator
CFP59_RS12735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS12735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS12740	COG2301	Belongs to the HpcH HpaI aldolase family
CFP59_RS12750	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS12755	COG0688	phosphatidylethanolamine metabolic process
CFP59_RS12765	COG1929	Belongs to the glycerate kinase type-1 family
CFP59_RS12790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CFP59_RS12825	COG0181	hydroxymethylbilane synthase activity
CFP59_RS12835	COG0483	inositol monophosphate 1-phosphatase activity
CFP59_RS12855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFP59_RS12860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFP59_RS12880	COG0477	Major facilitator Superfamily
CFP59_RS12885	COG1335	isochorismatase
CFP59_RS12890	COG0405	Gamma-glutamyltransferase
CFP59_RS12925	COG0765	amino acid transport
CFP59_RS12930	COG0765	amino acid transport
CFP59_RS12935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFP59_RS12940	COG1126	abc transporter atp-binding protein
CFP59_RS12965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFP59_RS12980	COG1940	carbohydrate kinase activity
CFP59_RS13000	COG2188	Transcriptional regulator
CFP59_RS13020	COG0800	Aldolase
CFP59_RS13060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CFP59_RS13065	COG4266	Belongs to the allantoicase family
CFP59_RS13070	COG1953	Uracil, thiamine, allantoin
CFP59_RS13075	COG1414	Transcriptional regulator
CFP59_RS13085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFP59_RS13090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CFP59_RS13105	COG2351	hydroxyisourate hydrolase activity
CFP59_RS13130	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS13135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS13140	COG2197	response regulator
CFP59_RS13145	COG0598	Magnesium transport protein CorA
CFP59_RS13150	COG0823	Involved in the tonB-independent uptake of proteins
CFP59_RS13165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS13195	COG1802	Transcriptional regulator
CFP59_RS13215	COG0028	Belongs to the TPP enzyme family
CFP59_RS13235	COG0583	DNA-binding transcription factor activity
CFP59_RS13245	COG1162	GTPase activity
CFP59_RS13320	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CFP59_RS13360	COG0175	sulfate reduction
CFP59_RS13365	COG0529	Catalyzes the synthesis of activated sulfate
CFP59_RS13385	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CFP59_RS13390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS13425	COG2409	Drug exporters of the RND superfamily
CFP59_RS13455	COG1175	transmembrane transport
CFP59_RS13480	COG1119	ATPase activity
CFP59_RS13575	COG0702	epimerase
CFP59_RS13630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFP59_RS13635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFP59_RS13680	COG5002	protein histidine kinase activity
CFP59_RS13685	COG0745	RESPONSE REGULATOR receiver
CFP59_RS13730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFP59_RS13735	COG3220	belongs to the UPF0276 family
CFP59_RS13755	COG3253	May function as heme-dependent peroxidase
CFP59_RS13760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CFP59_RS13765	COG1414	Transcriptional regulator
CFP59_RS13780	COG2271	Major facilitator Superfamily
CFP59_RS13785	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFP59_RS13795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CFP59_RS13815	COG0183	Belongs to the thiolase family
CFP59_RS13820	COG1024	Enoyl-CoA hydratase
CFP59_RS13820	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS13835	COG0531	amino acid
CFP59_RS13840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CFP59_RS13845	COG4214	carbohydrate transport
CFP59_RS13855	COG4213	ABC transporter substrate-binding protein
CFP59_RS13860	COG1940	carbohydrate kinase activity
CFP59_RS13865	COG0395	ABC-type sugar transport system, permease component
CFP59_RS13870	COG1175	transmembrane transport
CFP59_RS13875	COG1653	transport
CFP59_RS13895	COG1309	transcriptional regulator
CFP59_RS13915	COG1733	regulation of RNA biosynthetic process
CFP59_RS13920	COG0702	epimerase
CFP59_RS13925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFP59_RS13935	COG3537	Alpha-1,2-mannosidase
CFP59_RS13945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CFP59_RS13970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFP59_RS13975	COG3345	alpha-galactosidase
CFP59_RS13985	COG1175	transmembrane transport
CFP59_RS13990	COG0395	ABC-type sugar transport system, permease component
CFP59_RS14000	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS14010	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS14020	COG0800	Aldolase
CFP59_RS14025	COG3386	PFAM SMP-30 Gluconolaconase
CFP59_RS14040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFP59_RS14065	COG0477	Major facilitator Superfamily
CFP59_RS14070	COG4977	sequence-specific DNA binding
CFP59_RS14075	COG2040	homocysteine
CFP59_RS14105	COG2409	Drug exporters of the RND superfamily
CFP59_RS14115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFP59_RS14140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CFP59_RS14155	COG1233	COG1233 Phytoene dehydrogenase and related
CFP59_RS14160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS14185	COG2124	cytochrome p450
CFP59_RS14190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS14200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS14210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS14225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFP59_RS14230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFP59_RS14235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFP59_RS14255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS14260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS14265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS14270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFP59_RS14320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CFP59_RS14335	COG2124	cytochrome p450
CFP59_RS14355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CFP59_RS14370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFP59_RS14375	COG0531	amino acid
CFP59_RS14410	COG0569	domain protein
CFP59_RS14450	COG0756	dUTP diphosphatase activity
CFP59_RS14475	COG2205	protein histidine kinase activity
CFP59_RS14480	COG0745	RESPONSE REGULATOR receiver
CFP59_RS14485	COG0483	inositol monophosphate 1-phosphatase activity
CFP59_RS14490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CFP59_RS14525	COG1435	thymidine kinase activity
CFP59_RS14540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFP59_RS14540	COG1042	CoA-binding domain protein
CFP59_RS14540	COG0045	succinate-CoA ligase (ADP-forming) activity
CFP59_RS14545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFP59_RS14550	COG1802	Transcriptional regulator
CFP59_RS14565	COG0612	Peptidase, M16
CFP59_RS14570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFP59_RS14585	COG3290	protein histidine kinase activity
CFP59_RS14590	COG4565	transcriptional regulatory protein
CFP59_RS14595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFP59_RS14605	COG0187	DNA topoisomerase II activity
CFP59_RS14620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFP59_RS14625	COG1802	Transcriptional regulator
CFP59_RS14630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFP59_RS14660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFP59_RS14675	COG0488	(ABC) transporter
CFP59_RS14690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFP59_RS14695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFP59_RS14700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFP59_RS14730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFP59_RS14740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFP59_RS14745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CFP59_RS14755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFP59_RS14775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFP59_RS14780	COG1414	Transcriptional regulator
CFP59_RS14790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFP59_RS14795	COG2205	protein histidine kinase activity
CFP59_RS14800	COG0745	RESPONSE REGULATOR receiver
CFP59_RS14805	COG1126	abc transporter atp-binding protein
CFP59_RS14810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CFP59_RS14815	COG0765	amino acid transport
CFP59_RS14820	COG0765	amino acid transport
CFP59_RS14825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS14835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFP59_RS14880	COG1201	RNA secondary structure unwinding
CFP59_RS14885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFP59_RS14900	COG1396	sequence-specific DNA binding
CFP59_RS14905	COG1546	Belongs to the CinA family
CFP59_RS14905	COG1058	Belongs to the CinA family
CFP59_RS14915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFP59_RS14925	COG1674	ftsk spoiiie
CFP59_RS14935	COG3850	Histidine kinase
CFP59_RS14935	COG3437	response regulator, receiver
CFP59_RS14935	COG2205	protein histidine kinase activity
CFP59_RS14935	COG4999	Histidine kinase
CFP59_RS14940	COG2208	phosphoserine phosphatase activity
CFP59_RS14940	COG2770	Histidine kinase
CFP59_RS14975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CFP59_RS14980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS14985	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CFP59_RS15005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFP59_RS15010	COG0612	Peptidase, M16
CFP59_RS15015	COG1185	polyribonucleotide nucleotidyltransferase activity
CFP59_RS15020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFP59_RS15030	COG0515	serine threonine protein kinase
CFP59_RS15030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFP59_RS15060	COG1674	ftsk spoiiie
CFP59_RS15115	COG1404	Belongs to the peptidase S8 family
CFP59_RS15145	COG0455	bacterial-type flagellum organization
CFP59_RS15155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFP59_RS15160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFP59_RS15170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFP59_RS15185	COG0779	Required for maturation of 30S ribosomal subunits
CFP59_RS15205	COG0442	prolyl-tRNA aminoacylation
CFP59_RS15220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CFP59_RS15225	COG0750	zinc metalloprotease
CFP59_RS15230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CFP59_RS15240	COG1609	Transcriptional regulator
CFP59_RS15260	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS15265	COG2508	Transcriptional regulator
CFP59_RS15285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFP59_RS15290	COG1177	transmembrane transport
CFP59_RS15295	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFP59_RS15300	COG3842	ATPase activity
CFP59_RS15310	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS15320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFP59_RS15335	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS15345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFP59_RS15360	COG0028	Belongs to the TPP enzyme family
CFP59_RS15365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFP59_RS15380	COG3842	ATPase activity
CFP59_RS15385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CFP59_RS15395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFP59_RS15400	COG0575	Belongs to the CDS family
CFP59_RS15405	COG0233	cytoplasmic translational termination
CFP59_RS15410	COG0528	UMP kinase activity
CFP59_RS15415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFP59_RS15420	COG0052	Belongs to the universal ribosomal protein uS2 family
CFP59_RS15435	COG1191	sigma factor activity
CFP59_RS15450	COG0792	nuclease activity
CFP59_RS15460	COG1051	belongs to the nudix hydrolase family
CFP59_RS15465	COG0681	Belongs to the peptidase S26 family
CFP59_RS15470	COG0681	Belongs to the peptidase S26 family
CFP59_RS15475	COG0681	Belongs to the peptidase S26 family
CFP59_RS15480	COG0681	Belongs to the peptidase S26 family
CFP59_RS15485	COG0335	large ribosomal subunit rRNA binding
CFP59_RS15490	COG0336	Belongs to the RNA methyltransferase TrmD family
CFP59_RS15495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFP59_RS15500	COG1837	Belongs to the UPF0109 family
CFP59_RS15505	COG0228	four-way junction DNA binding
CFP59_RS15515	COG0442	prolyl-tRNA aminoacylation
CFP59_RS15530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CFP59_RS15560	COG2197	response regulator
CFP59_RS15565	COG4585	Histidine kinase
CFP59_RS15585	COG0477	Major facilitator Superfamily
CFP59_RS15600	COG1254	Belongs to the acylphosphatase family
CFP59_RS15605	COG2340	Cysteine-rich secretory protein family
CFP59_RS15610	COG1733	regulation of RNA biosynthetic process
CFP59_RS15615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFP59_RS15620	COG0571	ribonuclease III activity
CFP59_RS15625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFP59_RS15640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CFP59_RS15645	COG0742	ribosomal rna small subunit methyltransferase
CFP59_RS15650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFP59_RS15655	COG1461	Dihydroxyacetone kinase
CFP59_RS15660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFP59_RS15665	COG0351	phosphomethylpyrimidine kinase
CFP59_RS15685	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFP59_RS15690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFP59_RS15700	COG1920	GTP binding
CFP59_RS15705	COG0776	regulation of translation
CFP59_RS15715	COG0066	3-isopropylmalate dehydratase activity
CFP59_RS15720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFP59_RS15725	COG1414	Transcriptional regulator
CFP59_RS15765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFP59_RS15770	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFP59_RS15780	COG5002	protein histidine kinase activity
CFP59_RS15785	COG2018	Roadblock/LC7 domain
CFP59_RS15805	COG2018	Roadblock/LC7 domain
CFP59_RS15825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFP59_RS15830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFP59_RS15835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFP59_RS15840	COG0473	3-isopropylmalate dehydrogenase activity
CFP59_RS15855	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS15860	COG0506	proline dehydrogenase activity
CFP59_RS15910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFP59_RS15915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFP59_RS15920	COG0440	acetolactate synthase activity
CFP59_RS15940	COG0667	Aldo Keto reductase
CFP59_RS15945	COG2133	pyrroloquinoline quinone binding
CFP59_RS15950	COG1672	PFAM Archaeal ATPase
CFP59_RS15950	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CFP59_RS15960	COG2409	Drug exporters of the RND superfamily
CFP59_RS15970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFP59_RS15980	COG0154	amidase activity
CFP59_RS15985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFP59_RS15995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFP59_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS16015	COG1819	glycosyl
CFP59_RS16020	COG0789	Transcriptional regulator
CFP59_RS16030	COG0482	sulfurtransferase activity
CFP59_RS16055	COG0596	Alpha beta hydrolase
CFP59_RS16070	COG2860	membrane
CFP59_RS16075	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS16080	COG0444	Belongs to the ABC transporter superfamily
CFP59_RS16090	COG4166	transmembrane transport
CFP59_RS16115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CFP59_RS16120	COG0509	glycine decarboxylation via glycine cleavage system
CFP59_RS16125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFP59_RS16130	COG1760	l-serine dehydratase
CFP59_RS16140	COG1595	DNA-templated transcription, initiation
CFP59_RS16160	COG1846	Transcriptional regulator
CFP59_RS16180	COG1597	lipid kinase activity
CFP59_RS16230	COG1132	(ABC) transporter
CFP59_RS16235	COG1132	(ABC) transporter
CFP59_RS16265	COG3340	Belongs to the peptidase S51 family
CFP59_RS16285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFP59_RS16315	COG0058	SHG alpha-glucan phosphorylase activity
CFP59_RS16320	COG3401	FG-GAP repeat protein
CFP59_RS16340	COG0366	Alpha amylase catalytic
CFP59_RS16350	COG3281	Trehalose synthase
CFP59_RS16355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CFP59_RS16360	COG3903	Transcriptional regulator
CFP59_RS16360	COG3629	intracellular signal transduction
CFP59_RS16370	COG1301	dicarboxylic acid transport
CFP59_RS16375	COG3290	protein histidine kinase activity
CFP59_RS16380	COG4565	transcriptional regulatory protein
CFP59_RS16385	COG3469	chitinase activity
CFP59_RS16395	COG1175	transmembrane transport
CFP59_RS16420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS16425	COG1309	transcriptional regulator
CFP59_RS16430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS16445	COG1215	transferase activity, transferring glycosyl groups
CFP59_RS16450	COG1316	TRANSCRIPTIONal
CFP59_RS16455	COG3833	ABC-type maltose transport systems, permease component
CFP59_RS16480	COG0205	6-phosphofructokinase activity
CFP59_RS16485	COG0857	belongs to the CobB CobQ family
CFP59_RS16485	COG0280	phosphate acetyltransferase
CFP59_RS16490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFP59_RS16530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS16530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS16585	COG2205	protein histidine kinase activity
CFP59_RS16590	COG0745	RESPONSE REGULATOR receiver
CFP59_RS16605	COG0183	Belongs to the thiolase family
CFP59_RS16655	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CFP59_RS16665	COG0667	Aldo Keto reductase
CFP59_RS16685	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS16715	COG4585	Histidine kinase
CFP59_RS16720	COG2197	response regulator
CFP59_RS16730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFP59_RS16735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFP59_RS16740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFP59_RS16745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFP59_RS16750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFP59_RS16755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFP59_RS16760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFP59_RS16780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFP59_RS16785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFP59_RS16795	COG2890	protein-(glutamine-N5) methyltransferase activity
CFP59_RS16800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFP59_RS16805	COG0254	rRNA binding
CFP59_RS16810	COG1316	TRANSCRIPTIONal
CFP59_RS16820	COG0083	homoserine kinase activity
CFP59_RS16825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFP59_RS16830	COG0460	homoserine dehydrogenase
CFP59_RS16835	COG0019	diaminopimelate decarboxylase activity
CFP59_RS16840	COG0018	arginyl-trna synthetase
CFP59_RS16845	COG0745	RESPONSE REGULATOR receiver
CFP59_RS16985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFP59_RS17115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFP59_RS17155	COG0477	Major facilitator Superfamily
CFP59_RS17195	COG3103	Sh3 type 3 domain protein
CFP59_RS17195	COG1388	LysM domain
CFP59_RS17195	COG0791	NLP P60 protein
CFP59_RS17245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CFP59_RS17260	COG0745	RESPONSE REGULATOR receiver
CFP59_RS17265	COG2205	protein histidine kinase activity
CFP59_RS17270	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFP59_RS17270	COG0567	Dehydrogenase, E1 component
CFP59_RS17280	COG0789	Transcriptional regulator
CFP59_RS17305	COG0778	Nitroreductase
CFP59_RS17320	COG3321	synthase
CFP59_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS17320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS17320	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS17320	COG0300	oxidoreductase activity
CFP59_RS17345	COG0281	malic enzyme
CFP59_RS17355	COG0765	amino acid transport
CFP59_RS17405	COG0583	DNA-binding transcription factor activity
CFP59_RS17410	COG5640	endopeptidase activity
CFP59_RS17435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFP59_RS17455	COG2066	Belongs to the glutaminase family
CFP59_RS17495	COG1597	lipid kinase activity
CFP59_RS17510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFP59_RS17515	COG1472	Belongs to the glycosyl hydrolase 3 family
CFP59_RS17520	COG0395	ABC-type sugar transport system, permease component
CFP59_RS17525	COG1175	transmembrane transport
CFP59_RS17530	COG2182	Extracellular solute-binding protein
CFP59_RS17535	COG2188	Transcriptional regulator
CFP59_RS17620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFP59_RS17625	COG0242	peptide deformylase activity
CFP59_RS17640	COG2199	diguanylate cyclase activity
CFP59_RS17640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CFP59_RS17645	COG5662	AntiSigma factor
CFP59_RS17650	COG1595	DNA-templated transcription, initiation
CFP59_RS17660	COG2135	peptidase activity
CFP59_RS17670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFP59_RS17675	COG1162	GTPase activity
CFP59_RS17690	COG0483	inositol monophosphate 1-phosphatase activity
CFP59_RS17700	COG0753	catalase activity
CFP59_RS17730	COG1615	UPF0182 protein
CFP59_RS17740	COG3480	Lon protease (S16) C-terminal proteolytic domain
CFP59_RS17795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CFP59_RS17830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFP59_RS17935	COG0513	Belongs to the DEAD box helicase family
CFP59_RS17945	COG1432	Conserved Protein
CFP59_RS17950	COG2095	MarC family integral membrane protein
CFP59_RS17955	COG0613	PHP domain protein
CFP59_RS17970	COG0598	Magnesium transport protein CorA
CFP59_RS18010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFP59_RS18015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFP59_RS18025	COG1595	DNA-templated transcription, initiation
CFP59_RS18040	COG1024	Enoyl-CoA hydratase
CFP59_RS18045	COG0519	Catalyzes the synthesis of GMP from XMP
CFP59_RS18055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFP59_RS18060	COG1611	Belongs to the LOG family
CFP59_RS18065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFP59_RS18095	COG2912	Transglutaminase-like superfamily
CFP59_RS18110	COG2197	response regulator
CFP59_RS18130	COG4585	Histidine kinase
CFP59_RS18140	COG1131	(ABC) transporter
CFP59_RS18160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFP59_RS18180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS18185	COG0747	negative chemotaxis
CFP59_RS18195	COG0444	Belongs to the ABC transporter superfamily
CFP59_RS18200	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS18215	COG0596	Alpha beta hydrolase
CFP59_RS18220	COG4166	transmembrane transport
CFP59_RS18225	COG0601	transmembrane transport
CFP59_RS18230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS18235	COG0444	Belongs to the ABC transporter superfamily
CFP59_RS18240	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS18270	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS18275	COG0444	Belongs to the ABC transporter superfamily
CFP59_RS18280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS18285	COG0601	transmembrane transport
CFP59_RS18295	COG1217	gtp-binding protein TYPA
CFP59_RS18320	COG1053	succinate dehydrogenase
CFP59_RS18370	COG2223	nitrite transmembrane transporter activity
CFP59_RS18395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFP59_RS18400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFP59_RS18415	COG1091	dTDP-4-dehydrorhamnose reductase activity
CFP59_RS18420	COG1063	alcohol dehydrogenase
CFP59_RS18445	COG0745	RESPONSE REGULATOR receiver
CFP59_RS18450	COG1132	(ABC) transporter
CFP59_RS18460	COG2205	protein histidine kinase activity
CFP59_RS18465	COG0745	RESPONSE REGULATOR receiver
CFP59_RS18480	COG1136	(ABC) transporter
CFP59_RS18480	COG0577	efflux transmembrane transporter activity
CFP59_RS18485	COG1136	(ABC) transporter
CFP59_RS18485	COG0577	efflux transmembrane transporter activity
CFP59_RS18545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CFP59_RS18560	COG0012	GTP binding
CFP59_RS18575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CFP59_RS18580	COG1570	exodeoxyribonuclease VII activity
CFP59_RS18585	COG1722	exodeoxyribonuclease VII activity
CFP59_RS18590	COG0778	Nitroreductase
CFP59_RS18615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CFP59_RS18615	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CFP59_RS18620	COG3979	chitinase
CFP59_RS18635	COG0114	fumarate hydratase activity
CFP59_RS18645	COG2264	protein methyltransferase activity
CFP59_RS18655	COG1309	transcriptional regulator
CFP59_RS18660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFP59_RS18665	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CFP59_RS18665	COG1082	Xylose isomerase domain protein TIM barrel
CFP59_RS18675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFP59_RS18695	COG1136	(ABC) transporter
CFP59_RS18710	COG0450	alkyl hydroperoxide reductase
CFP59_RS18715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFP59_RS18730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CFP59_RS18735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFP59_RS18750	COG1278	Cold shock
CFP59_RS18755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFP59_RS18760	COG2885	chlorophyll binding
CFP59_RS18795	COG2894	cell division
CFP59_RS18910	COG0513	Belongs to the DEAD box helicase family
CFP59_RS18915	COG1278	Cold shock
CFP59_RS18940	COG1131	(ABC) transporter
CFP59_RS18945	COG2610	gluconate transmembrane transporter activity
CFP59_RS18950	COG0251	oxidation-reduction process
CFP59_RS18955	COG1414	Transcriptional regulator
CFP59_RS18970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CFP59_RS19000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS19005	COG0601	transmembrane transport
CFP59_RS19025	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CFP59_RS19030	COG1272	protein, Hemolysin III
CFP59_RS19040	COG1331	Highly conserved protein containing a thioredoxin domain
CFP59_RS19045	COG3629	intracellular signal transduction
CFP59_RS19045	COG3903	Transcriptional regulator
CFP59_RS19055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFP59_RS19065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFP59_RS19080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFP59_RS19110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFP59_RS19150	COG2318	DinB family
CFP59_RS19230	COG2226	methyltransferase
CFP59_RS19255	COG0601	transmembrane transport
CFP59_RS19260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS19270	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS19310	COG2084	Dehydrogenase
CFP59_RS19315	COG1082	Xylose isomerase domain protein TIM barrel
CFP59_RS19320	COG0149	triose-phosphate isomerase activity
CFP59_RS19325	COG0698	ribose 5-phosphate isomerase
CFP59_RS19330	COG2376	Dihydroxyacetone kinase
CFP59_RS19340	COG2186	Transcriptional regulator
CFP59_RS19390	COG0577	efflux transmembrane transporter activity
CFP59_RS19395	COG1136	(ABC) transporter
CFP59_RS19400	COG0477	Major facilitator Superfamily
CFP59_RS19430	COG4585	Histidine kinase
CFP59_RS19440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFP59_RS19445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFP59_RS19450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFP59_RS19455	COG0193	aminoacyl-tRNA hydrolase activity
CFP59_RS19465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CFP59_RS19475	COG1309	transcriptional regulator
CFP59_RS19485	COG4106	trans-aconitate 2-methyltransferase activity
CFP59_RS19495	COG2197	response regulator
CFP59_RS19500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CFP59_RS19535	COG0488	(ABC) transporter
CFP59_RS19540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFP59_RS19545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFP59_RS19550	COG3583	domain protein
CFP59_RS19550	COG3584	3D domain protein
CFP59_RS19555	COG0084	hydrolase, TatD family'
CFP59_RS19615	COG4166	transmembrane transport
CFP59_RS19630	COG1122	ATPase activity
CFP59_RS19640	COG0310	cobalt ion transport
CFP59_RS19650	COG1309	transcriptional regulator
CFP59_RS19655	COG2409	Drug exporters of the RND superfamily
CFP59_RS19665	COG0793	Belongs to the peptidase S41A family
CFP59_RS19665	COG4946	Tricorn protease homolog
CFP59_RS19685	COG2267	carboxylic ester hydrolase activity
CFP59_RS19690	COG2072	flavoprotein involved in K transport
CFP59_RS19695	COG0789	Transcriptional regulator
CFP59_RS19700	COG0708	Exodeoxyribonuclease III
CFP59_RS19720	COG0783	Belongs to the Dps family
CFP59_RS19735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFP59_RS19740	COG0521	Mo-molybdopterin cofactor biosynthetic process
CFP59_RS19745	COG0315	cyclic pyranopterin monophosphate synthase activity
CFP59_RS19755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CFP59_RS19760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFP59_RS19770	COG3263	regulation of cellular component size
CFP59_RS19780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CFP59_RS19790	COG1970	mechanosensitive ion channel activity
CFP59_RS19800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS19805	COG3191	aminopeptidase activity
CFP59_RS19810	COG3634	alkyl hydroperoxide reductase activity
CFP59_RS19815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFP59_RS19815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFP59_RS19815	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CFP59_RS19820	COG1105	Belongs to the carbohydrate kinase PfkB family
CFP59_RS19825	COG1349	DNA-binding transcription factor activity
CFP59_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS19850	COG3384	dioxygenase
CFP59_RS19855	COG1846	Transcriptional regulator
CFP59_RS19910	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CFP59_RS20080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CFP59_RS20110	COG4221	oxidoreductase activity
CFP59_RS20145	COG0494	nUDIX hydrolase
CFP59_RS20150	COG0494	nUDIX hydrolase
CFP59_RS20175	COG1175	transmembrane transport
CFP59_RS20180	COG0395	ABC-type sugar transport system, permease component
CFP59_RS20200	COG0640	Transcriptional regulator
CFP59_RS20225	COG0596	Alpha beta hydrolase
CFP59_RS20250	COG0515	serine threonine protein kinase
CFP59_RS20265	COG3246	L-lysine catabolic process to acetate
CFP59_RS20270	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS20275	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS20275	COG0824	Thioesterase
CFP59_RS20290	COG0640	Transcriptional regulator
CFP59_RS20295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CFP59_RS20300	COG1793	dna ligase
CFP59_RS20305	COG1793	dna ligase
CFP59_RS20305	COG3285	dna ligase
CFP59_RS20310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CFP59_RS20325	COG1309	transcriptional regulator
CFP59_RS20355	COG0515	serine threonine protein kinase
CFP59_RS20370	COG1653	transport
CFP59_RS20380	COG1686	Belongs to the peptidase S11 family
CFP59_RS20430	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CFP59_RS20510	COG1024	Enoyl-CoA hydratase
CFP59_RS20525	COG0515	serine threonine protein kinase
CFP59_RS20525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFP59_RS20535	COG1309	transcriptional regulator
CFP59_RS20545	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS20555	COG0259	pyridoxamine-phosphate oxidase activity
CFP59_RS20570	COG2072	flavoprotein involved in K transport
CFP59_RS20580	COG1024	Enoyl-CoA hydratase
CFP59_RS20585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFP59_RS20610	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS20615	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS20630	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS20635	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS20640	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS20660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFP59_RS20675	COG1077	Cell shape determining protein MreB Mrl
CFP59_RS20690	COG0516	GMP reductase activity
CFP59_RS20700	COG1595	DNA-templated transcription, initiation
CFP59_RS20705	COG2197	response regulator
CFP59_RS20715	COG0583	DNA-binding transcription factor activity
CFP59_RS20725	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS20730	COG0459	protein refolding
CFP59_RS20735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFP59_RS20740	COG0726	polysaccharide deacetylase
CFP59_RS20790	COG0596	Alpha beta hydrolase
CFP59_RS20795	COG3629	intracellular signal transduction
CFP59_RS20795	COG3903	Transcriptional regulator
CFP59_RS20800	COG0667	Aldo Keto reductase
CFP59_RS20805	COG0583	DNA-binding transcription factor activity
CFP59_RS20815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFP59_RS20840	COG0802	atpase or kinase
CFP59_RS20855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFP59_RS20880	COG0736	holo-[acyl-carrier-protein] synthase activity
CFP59_RS20885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFP59_RS20890	COG1072	(Pantothenic acid kinase))
CFP59_RS20900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFP59_RS20905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFP59_RS20910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFP59_RS20935	COG2770	Histidine kinase
CFP59_RS20935	COG2208	phosphoserine phosphatase activity
CFP59_RS20945	COG2172	sigma factor antagonist activity
CFP59_RS20950	COG1366	Belongs to the anti-sigma-factor antagonist family
CFP59_RS20955	COG1366	Belongs to the anti-sigma-factor antagonist family
CFP59_RS20960	COG0101	tRNA pseudouridine synthase activity
CFP59_RS20965	COG0203	ribosomal protein L17
CFP59_RS20970	COG0202	RNA polymerase activity
CFP59_RS20975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFP59_RS20980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFP59_RS20985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFP59_RS20990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFP59_RS20995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFP59_RS21005	COG0563	adenylate kinase activity
CFP59_RS21015	COG0200	Binds to the 23S rRNA
CFP59_RS21025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFP59_RS21030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFP59_RS21035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFP59_RS21040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFP59_RS21050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFP59_RS21055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFP59_RS21060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFP59_RS21065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFP59_RS21070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFP59_RS21075	COG0255	Belongs to the universal ribosomal protein uL29 family
CFP59_RS21080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFP59_RS21085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFP59_RS21090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFP59_RS21095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFP59_RS21100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFP59_RS21105	COG0089	rRNA binding
CFP59_RS21110	COG0088	Forms part of the polypeptide exit tunnel
CFP59_RS21115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFP59_RS21120	COG0051	transcription antitermination factor activity, RNA binding
CFP59_RS21135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFP59_RS21140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFP59_RS21145	COG0049	tRNA binding
CFP59_RS21150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFP59_RS21185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFP59_RS21190	COG0085	RNA polymerase activity
CFP59_RS21200	COG0222	ribosome binding
CFP59_RS21205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFP59_RS21215	COG0081	regulation of translation
CFP59_RS21220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CFP59_RS21240	COG0436	Aminotransferase
CFP59_RS21245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFP59_RS21250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CFP59_RS21260	COG2030	dehydratase
CFP59_RS21265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFP59_RS21285	COG0702	epimerase
CFP59_RS21300	COG1970	mechanosensitive ion channel activity
CFP59_RS21310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFP59_RS21315	COG1063	alcohol dehydrogenase
CFP59_RS21325	COG1666	GTP binding
CFP59_RS21330	COG3304	Inner membrane component domain
CFP59_RS21335	COG0501	Belongs to the peptidase M48B family
CFP59_RS21340	COG1007	ATP synthesis coupled electron transport
CFP59_RS21350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFP59_RS21355	COG0713	ATP synthesis coupled electron transport
CFP59_RS21360	COG0839	Belongs to the complex I subunit 6 family
CFP59_RS21365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFP59_RS21370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CFP59_RS21375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFP59_RS21380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFP59_RS21385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFP59_RS21390	COG4585	Histidine kinase
CFP59_RS21395	COG4585	Histidine kinase
CFP59_RS21405	COG0674	pyruvate-flavodoxin oxidoreductase activity
CFP59_RS21405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CFP59_RS21410	COG1013	pyruvate-flavodoxin oxidoreductase activity
CFP59_RS21415	COG0531	amino acid
CFP59_RS21420	COG0702	epimerase
CFP59_RS21450	COG0142	geranyltranstransferase activity
CFP59_RS21455	COG0492	ferredoxin-NADP+ reductase activity
CFP59_RS21480	COG1007	ATP synthesis coupled electron transport
CFP59_RS21490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFP59_RS21495	COG0713	ATP synthesis coupled electron transport
CFP59_RS21500	COG0839	Belongs to the complex I subunit 6 family
CFP59_RS21505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFP59_RS21510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CFP59_RS21515	COG1034	ATP synthesis coupled electron transport
CFP59_RS21520	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CFP59_RS21530	COG0649	NAD binding
CFP59_RS21535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFP59_RS21540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFP59_RS21570	COG2226	methyltransferase
CFP59_RS21580	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CFP59_RS21590	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CFP59_RS21595	COG1278	Cold shock
CFP59_RS21615	COG1309	transcriptional regulator
CFP59_RS21625	COG2076	Multidrug Resistance protein
CFP59_RS21630	COG1301	dicarboxylic acid transport
CFP59_RS21645	COG1573	uracil-dna glycosylase
CFP59_RS21650	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CFP59_RS21660	COG0163	prenyltransferase activity
CFP59_RS21665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CFP59_RS21670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CFP59_RS21680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFP59_RS21685	COG1333	cytochrome c biogenesis protein
CFP59_RS21695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFP59_RS21705	COG0406	alpha-ribazole phosphatase activity
CFP59_RS21710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFP59_RS21735	COG1742	UPF0060 membrane protein
CFP59_RS21745	COG4221	oxidoreductase activity
CFP59_RS21755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFP59_RS21765	COG1690	Belongs to the RtcB family
CFP59_RS21785	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CFP59_RS21790	COG0018	arginyl-trna synthetase
CFP59_RS21810	COG1072	(Pantothenic acid kinase))
CFP59_RS21815	COG0113	porphobilinogen synthase activity
CFP59_RS21820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CFP59_RS21820	COG1648	precorrin-2 dehydrogenase activity
CFP59_RS21825	COG0181	hydroxymethylbilane synthase activity
CFP59_RS21830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFP59_RS21835	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CFP59_RS21885	COG0123	including yeast histone deacetylase and acetoin utilization protein
CFP59_RS21895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFP59_RS21920	COG0180	Tryptophanyl-tRNA synthetase
CFP59_RS21925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFP59_RS21955	COG0129	dihydroxy-acid dehydratase activity
CFP59_RS21965	COG1082	Xylose isomerase domain protein TIM barrel
CFP59_RS21970	COG0248	Ppx GppA phosphatase
CFP59_RS21990	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CFP59_RS22000	COG1194	a g-specific adenine glycosylase
CFP59_RS22010	COG1595	DNA-templated transcription, initiation
CFP59_RS22020	COG0745	RESPONSE REGULATOR receiver
CFP59_RS22025	COG2205	protein histidine kinase activity
CFP59_RS22030	COG0346	lactoylglutathione lyase activity
CFP59_RS22050	COG0739	heme binding
CFP59_RS22095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS22105	COG0724	RNA recognition motif
CFP59_RS22130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFP59_RS22135	COG1609	Transcriptional regulator
CFP59_RS22140	COG0745	RESPONSE REGULATOR receiver
CFP59_RS22175	COG2897	thiosulfate sulfurtransferase activity
CFP59_RS22195	COG3485	protocatechuate 3,4-dioxygenase
CFP59_RS22200	COG0735	belongs to the Fur family
CFP59_RS22210	COG1490	D-aminoacyl-tRNA deacylase activity
CFP59_RS22220	COG4552	Acetyltransferase involved in intracellular survival and related
CFP59_RS22260	COG0667	Aldo Keto reductase
CFP59_RS22265	COG4941	Belongs to the sigma-70 factor family
CFP59_RS22295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CFP59_RS22320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFP59_RS22325	COG0306	phosphate transporter
CFP59_RS22335	COG1937	Protein conserved in bacteria
CFP59_RS22355	COG0277	FAD linked oxidase domain protein
CFP59_RS22360	COG0671	phosphoesterase, PA-phosphatase related
CFP59_RS22365	COG1196	nuclear chromosome segregation
CFP59_RS22365	COG0739	heme binding
CFP59_RS22365	COG0741	lytic transglycosylase activity
CFP59_RS22420	COG1846	Transcriptional regulator
CFP59_RS22435	COG1252	NADH dehydrogenase
CFP59_RS22460	COG0579	oxidoreductase
CFP59_RS22465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFP59_RS22480	COG1376	ErfK ybiS ycfS ynhG family protein
CFP59_RS22490	COG0556	nucleotide-excision repair
CFP59_RS22500	COG0667	Aldo Keto reductase
CFP59_RS22545	COG0513	Belongs to the DEAD box helicase family
CFP59_RS22645	COG1643	Atp-dependent helicase
CFP59_RS22670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFP59_RS22680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFP59_RS22700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFP59_RS22705	COG0047	phosphoribosylformylglycinamidine synthase activity
CFP59_RS22710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFP59_RS22740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFP59_RS22760	COG0151	Belongs to the GarS family
CFP59_RS22780	COG1802	Transcriptional regulator
CFP59_RS22785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFP59_RS22795	COG0515	serine threonine protein kinase
CFP59_RS22795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFP59_RS22800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFP59_RS22815	COG1131	(ABC) transporter
CFP59_RS22820	COG3559	Exporter of polyketide antibiotics
CFP59_RS22830	COG2197	response regulator
CFP59_RS22845	COG3844	kynureninase activity
CFP59_RS22860	COG0477	Major facilitator Superfamily
CFP59_RS22865	COG0191	fructose-bisphosphate aldolase activity
CFP59_RS22870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFP59_RS22885	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CFP59_RS22935	COG0542	response to heat
CFP59_RS22945	COG0477	Major facilitator Superfamily
CFP59_RS22955	COG0789	Transcriptional regulator
CFP59_RS22960	COG0484	heat shock protein binding
CFP59_RS22965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFP59_RS22970	COG0443	Heat shock 70 kDa protein
CFP59_RS22975	COG2181	nitrate reductase activity
CFP59_RS22975	COG0247	lactate metabolic process
CFP59_RS22980	COG3290	protein histidine kinase activity
CFP59_RS23000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CFP59_RS23005	COG0717	Belongs to the dCTP deaminase family
CFP59_RS23065	COG2188	Transcriptional regulator
CFP59_RS23145	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFP59_RS23155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFP59_RS23190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFP59_RS23205	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS23230	COG0726	polysaccharide deacetylase
CFP59_RS23250	COG3629	intracellular signal transduction
CFP59_RS23250	COG3903	Transcriptional regulator
CFP59_RS23280	COG0515	serine threonine protein kinase
CFP59_RS23280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFP59_RS23305	COG0583	DNA-binding transcription factor activity
CFP59_RS23320	COG0531	amino acid
CFP59_RS23365	COG0725	ABC transporter, periplasmic molybdate-binding protein
CFP59_RS23445	COG4585	Histidine kinase
CFP59_RS23450	COG2197	response regulator
CFP59_RS23505	COG2018	Roadblock/LC7 domain
CFP59_RS23515	COG3290	protein histidine kinase activity
CFP59_RS23525	COG1793	dna ligase
CFP59_RS23560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFP59_RS23575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFP59_RS23585	COG2837	iron assimilation
CFP59_RS23605	COG1741	Belongs to the pirin family
CFP59_RS23615	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS23630	COG1362	aminopeptidase activity
CFP59_RS23675	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFP59_RS23680	COG0022	dehydrogenase e1 component
CFP59_RS23700	COG0515	serine threonine protein kinase
CFP59_RS23705	COG0515	serine threonine protein kinase
CFP59_RS23720	COG0604	alcohol dehydrogenase
CFP59_RS23720	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS23720	COG3321	synthase
CFP59_RS23725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CFP59_RS23760	COG1522	sequence-specific DNA binding
CFP59_RS23765	COG1309	transcriptional regulator
CFP59_RS23770	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS23795	COG3396	Phenylacetate-CoA oxygenase
CFP59_RS23800	COG3460	Phenylacetate-CoA oxygenase
CFP59_RS23805	COG3396	Phenylacetate-CoA oxygenase
CFP59_RS23810	COG2151	metal-sulfur cluster biosynthetic enzyme
CFP59_RS23815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFP59_RS23840	COG1733	regulation of RNA biosynthetic process
CFP59_RS23845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFP59_RS23860	COG1716	ATPase activity
CFP59_RS23865	COG1716	ATPase activity
CFP59_RS23880	COG0768	penicillin binding
CFP59_RS23885	COG0515	serine threonine protein kinase
CFP59_RS23890	COG3764	Sortase (surface protein transpeptidase)
CFP59_RS23895	COG3764	Sortase (surface protein transpeptidase)
CFP59_RS23905	COG3764	Sortase (surface protein transpeptidase)
CFP59_RS23920	COG0705	Rhomboid family
CFP59_RS23950	COG0515	serine threonine protein kinase
CFP59_RS23975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFP59_RS23980	COG0187	DNA topoisomerase II activity
CFP59_RS23985	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CFP59_RS23990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFP59_RS23995	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CFP59_RS24000	COG0592	DNA-directed DNA polymerase activity
CFP59_RS24015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CFP59_RS24020	COG0594	ribonuclease P activity
CFP59_RS24025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFP59_RS24030	COG0706	membrane insertase activity
CFP59_RS24040	COG0357	Ribosomal RNA small subunit methyltransferase G
CFP59_RS24045	COG1192	Involved in chromosome partitioning
CFP59_RS24060	COG3118	belongs to the thioredoxin family
CFP59_RS24065	COG0492	ferredoxin-NADP+ reductase activity
CFP59_RS24075	COG1595	DNA-templated transcription, initiation
CFP59_RS24080	COG0515	serine threonine protein kinase
CFP59_RS24080	COG2815	serine threonine protein kinase
CFP59_RS24095	COG0617	tRNA 3'-terminal CCA addition
CFP59_RS24105	COG1260	myo-inositol-1-phosphate synthase
CFP59_RS24115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFP59_RS24140	COG0360	Binds together with S18 to 16S ribosomal RNA
CFP59_RS24145	COG0629	single-stranded DNA binding
CFP59_RS24150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFP59_RS24155	COG0359	binds to the 23S rRNA
CFP59_RS24165	COG0305	Participates in initiation and elongation during chromosome replication
CFP59_RS24170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFP59_RS24175	COG0242	peptide deformylase activity
CFP59_RS24240	COG0626	cystathionine gamma-synthase activity
CFP59_RS24245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFP59_RS24250	COG1950	PFAM Membrane protein of
CFP59_RS24255	COG0662	Cupin 2, conserved barrel domain protein
CFP59_RS24275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CFP59_RS24295	COG1609	Transcriptional regulator
CFP59_RS24300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFP59_RS24305	COG1271	oxidase subunit
CFP59_RS24310	COG1294	oxidase, subunit
CFP59_RS24320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CFP59_RS24340	COG0561	phosphatase activity
CFP59_RS24350	COG0501	Belongs to the peptidase M48B family
CFP59_RS24360	COG1131	(ABC) transporter
CFP59_RS24380	COG2807	transmembrane transport
CFP59_RS24405	COG0561	phosphatase activity
CFP59_RS24410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFP59_RS24415	COG0077	Prephenate dehydratase
CFP59_RS24420	COG2837	iron assimilation
CFP59_RS24425	COG2372	response to copper ion
CFP59_RS24435	COG1999	signal sequence binding
CFP59_RS24455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFP59_RS24460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFP59_RS24465	COG0006	proline dipeptidase activity
CFP59_RS24480	COG0653	protein targeting
CFP59_RS24495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFP59_RS24515	COG2801	Transposase and inactivated derivatives
CFP59_RS24560	COG2188	Transcriptional regulator
CFP59_RS24640	COG1595	DNA-templated transcription, initiation
CFP59_RS24645	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS24650	COG5000	phosphorelay sensor kinase activity
CFP59_RS24710	COG0745	RESPONSE REGULATOR receiver
CFP59_RS24715	COG2205	protein histidine kinase activity
CFP59_RS24725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CFP59_RS24725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CFP59_RS24730	COG0477	Major facilitator Superfamily
CFP59_RS24770	COG1191	sigma factor activity
CFP59_RS24775	COG1191	sigma factor activity
CFP59_RS24780	COG0205	6-phosphofructokinase activity
CFP59_RS24815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CFP59_RS24830	COG0702	epimerase
CFP59_RS24835	COG2124	cytochrome p450
CFP59_RS24845	COG0501	Belongs to the peptidase M48B family
CFP59_RS24890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFP59_RS24905	COG2197	response regulator
CFP59_RS24910	COG4585	Histidine kinase
CFP59_RS24965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFP59_RS24970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFP59_RS25065	COG1408	metallophosphoesterase
CFP59_RS25075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFP59_RS25090	COG0003	Pfam Anion-transporting ATPase
CFP59_RS25120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFP59_RS25150	COG2267	carboxylic ester hydrolase activity
CFP59_RS25160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFP59_RS25165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS25225	COG1366	Belongs to the anti-sigma-factor antagonist family
CFP59_RS25230	COG2172	sigma factor antagonist activity
CFP59_RS25235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CFP59_RS25245	COG2890	protein-(glutamine-N5) methyltransferase activity
CFP59_RS25255	COG1754	DNA topoisomerase type I activity
CFP59_RS25255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFP59_RS25260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFP59_RS25265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFP59_RS25310	COG3573	Dehydrogenase
CFP59_RS25315	COG0129	dihydroxy-acid dehydratase activity
CFP59_RS25320	COG2271	Major facilitator Superfamily
CFP59_RS25330	COG0066	3-isopropylmalate dehydratase activity
CFP59_RS25335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFP59_RS25340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFP59_RS25345	COG0066	3-isopropylmalate dehydratase activity
CFP59_RS25350	COG2423	ornithine cyclodeaminase activity
CFP59_RS25360	COG0006	proline dipeptidase activity
CFP59_RS25365	COG2271	Major facilitator Superfamily
CFP59_RS25380	COG0640	Transcriptional regulator
CFP59_RS25390	COG1191	sigma factor activity
CFP59_RS25420	COG4585	Histidine kinase
CFP59_RS25425	COG2197	response regulator
CFP59_RS25430	COG0671	phosphoesterase, PA-phosphatase related
CFP59_RS25485	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CFP59_RS25500	COG1595	DNA-templated transcription, initiation
CFP59_RS25520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFP59_RS25520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFP59_RS25545	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS25550	COG2318	DinB family
CFP59_RS25580	COG0076	glutamate decarboxylase activity
CFP59_RS25590	COG0789	Transcriptional regulator
CFP59_RS25595	COG0586	Pfam SNARE associated Golgi protein
CFP59_RS25605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CFP59_RS25610	COG2027	D-alanyl-D-alanine carboxypeptidase
CFP59_RS25620	COG0037	tRNA processing
CFP59_RS25635	COG0302	gtp cyclohydrolase
CFP59_RS25645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFP59_RS25650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CFP59_RS25675	COG1125	glycine betaine transport
CFP59_RS25675	COG0517	IMP dehydrogenase activity
CFP59_RS25680	COG1174	glycine betaine transport
CFP59_RS25685	COG1174	glycine betaine transport
CFP59_RS25700	COG0649	NAD binding
CFP59_RS25715	COG2197	response regulator
CFP59_RS25725	COG0640	Transcriptional regulator
CFP59_RS25745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CFP59_RS25750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CFP59_RS25760	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CFP59_RS25780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CFP59_RS25840	COG1733	regulation of RNA biosynthetic process
CFP59_RS25845	COG1024	Enoyl-CoA hydratase
CFP59_RS25860	COG0737	Belongs to the 5'-nucleotidase family
CFP59_RS25865	COG4804	nuclease activity
CFP59_RS25870	COG0456	acetyltransferase
CFP59_RS25870	COG0454	-acetyltransferase
CFP59_RS25875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CFP59_RS25885	COG0406	alpha-ribazole phosphatase activity
CFP59_RS25885	COG0494	nUDIX hydrolase
CFP59_RS25890	COG1126	abc transporter atp-binding protein
CFP59_RS25905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFP59_RS25920	COG0667	Aldo Keto reductase
CFP59_RS25940	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS25975	COG0588	phosphoglycerate mutase activity
CFP59_RS25985	COG2188	Transcriptional regulator
CFP59_RS25990	COG1216	Glycosyl transferase, family 2
CFP59_RS25990	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS26005	COG2319	Wd-40 repeat
CFP59_RS26005	COG4249	Peptidase C14 caspase catalytic subunit p20
CFP59_RS26020	COG5002	protein histidine kinase activity
CFP59_RS26040	COG1329	Transcriptional regulator
CFP59_RS26045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFP59_RS26050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CFP59_RS26055	COG0215	cysteine-tRNA ligase activity
CFP59_RS26060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFP59_RS26080	COG3842	ATPase activity
CFP59_RS26130	COG1064	alcohol dehydrogenase
CFP59_RS26135	COG1309	transcriptional regulator
CFP59_RS26150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFP59_RS26155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFP59_RS26175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CFP59_RS26180	COG1940	carbohydrate kinase activity
CFP59_RS26195	COG1877	trehalose-phosphatase activity
CFP59_RS26195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFP59_RS26205	COG0463	Glycosyl transferase, family 2
CFP59_RS26220	COG1278	Cold shock
CFP59_RS26225	COG0459	protein refolding
CFP59_RS26230	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CFP59_RS26235	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CFP59_RS26250	COG2197	response regulator
CFP59_RS26255	COG3851	Histidine kinase
CFP59_RS26270	COG0475	glutathione-regulated potassium exporter activity
CFP59_RS26300	COG0326	Molecular chaperone. Has ATPase activity
CFP59_RS26315	COG3142	Participates in the control of copper homeostasis
CFP59_RS26325	COG3973	AAA domain
CFP59_RS26330	COG1061	Type III restriction enzyme res subunit
CFP59_RS26355	COG1120	ATPase activity
CFP59_RS26360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS26365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS26380	COG1278	Cold shock
CFP59_RS26385	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CFP59_RS26390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFP59_RS26400	COG2814	Major facilitator Superfamily
CFP59_RS26425	COG2252	PERMEase
CFP59_RS26445	COG0667	Aldo Keto reductase
CFP59_RS26460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CFP59_RS26465	COG0277	FAD linked oxidase domain protein
CFP59_RS26465	COG0247	lactate metabolic process
CFP59_RS26475	COG2442	InterPro IPR007367
CFP59_RS26510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFP59_RS26525	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS26545	COG0259	pyridoxamine-phosphate oxidase activity
CFP59_RS26555	COG4821	SIS domain
CFP59_RS26565	COG2945	thiolester hydrolase activity
CFP59_RS26565	COG0596	Alpha beta hydrolase
CFP59_RS26640	COG1366	Belongs to the anti-sigma-factor antagonist family
CFP59_RS26645	COG3851	Histidine kinase
CFP59_RS26650	COG2197	response regulator
CFP59_RS26670	COG0515	serine threonine protein kinase
CFP59_RS26680	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS26700	COG0519	Catalyzes the synthesis of GMP from XMP
CFP59_RS26700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFP59_RS26725	COG0515	serine threonine protein kinase
CFP59_RS26745	COG2197	response regulator
CFP59_RS26765	COG0460	homoserine dehydrogenase
CFP59_RS26795	COG0739	heme binding
CFP59_RS26805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS26820	COG0714	Associated with various cellular activities
CFP59_RS26830	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CFP59_RS26845	COG0045	succinate-CoA ligase (ADP-forming) activity
CFP59_RS26870	COG0138	bifunctional purine biosynthesis protein purh
CFP59_RS26875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFP59_RS26890	COG0039	L-malate dehydrogenase activity
CFP59_RS26915	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS26925	COG0517	IMP dehydrogenase activity
CFP59_RS26925	COG4175	Glycine betaine
CFP59_RS26930	COG4176	ABC-type proline glycine betaine transport system permease component
CFP59_RS26945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFP59_RS26950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFP59_RS26965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFP59_RS26970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFP59_RS26980	COG0180	Tryptophanyl-tRNA synthetase
CFP59_RS27010	COG1295	ribonuclease BN
CFP59_RS27015	COG1686	Belongs to the peptidase S11 family
CFP59_RS27020	COG1408	metallophosphoesterase
CFP59_RS27030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFP59_RS27035	COG1053	succinate dehydrogenase
CFP59_RS27045	COG2009	succinate dehydrogenase
CFP59_RS27080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS27080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS27110	COG1316	TRANSCRIPTIONal
CFP59_RS27120	COG2186	Transcriptional regulator
CFP59_RS27125	COG3265	gluconokinase activity
CFP59_RS27135	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS27140	COG1063	alcohol dehydrogenase
CFP59_RS27160	COG0667	Aldo Keto reductase
CFP59_RS27215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CFP59_RS27225	COG1216	Glycosyl transferase, family 2
CFP59_RS27235	COG1083	cytidylyl-transferase
CFP59_RS27240	COG2089	acid synthase
CFP59_RS27250	COG1473	amidohydrolase
CFP59_RS27250	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CFP59_RS27260	COG1744	ABC transporter substrate-binding protein PnrA-like
CFP59_RS27270	COG4603	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS27275	COG1079	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS27290	COG0583	DNA-binding transcription factor activity
CFP59_RS27295	COG2814	Major facilitator Superfamily
CFP59_RS27305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFP59_RS27330	COG2205	protein histidine kinase activity
CFP59_RS27335	COG0745	RESPONSE REGULATOR receiver
CFP59_RS27340	COG1595	DNA-templated transcription, initiation
CFP59_RS27350	COG0477	Major facilitator Superfamily
CFP59_RS27350	COG2814	Major facilitator Superfamily
CFP59_RS27360	COG2159	amidohydrolase
CFP59_RS27365	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS27370	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS27385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFP59_RS27420	COG4770	biotin carboxylase activity
CFP59_RS27430	COG0424	maF-like protein
CFP59_RS27440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFP59_RS27450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CFP59_RS27460	COG1024	Enoyl-CoA hydratase
CFP59_RS27470	COG2986	histidine ammonia-lyase
CFP59_RS27520	COG3033	Beta-eliminating lyase
CFP59_RS27555	COG2124	cytochrome p450
CFP59_RS27560	COG1652	LysM domain
CFP59_RS27570	COG0148	phosphopyruvate hydratase activity
CFP59_RS27590	COG1252	NADH dehydrogenase
CFP59_RS27595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFP59_RS27600	COG0577	efflux transmembrane transporter activity
CFP59_RS27610	COG1136	(ABC) transporter
CFP59_RS27640	COG0183	Belongs to the thiolase family
CFP59_RS27645	COG2755	lipolytic protein G-D-S-L family
CFP59_RS27660	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS27675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CFP59_RS27690	COG1174	glycine betaine transport
CFP59_RS27700	COG2986	histidine ammonia-lyase
CFP59_RS27715	COG0019	diaminopimelate decarboxylase activity
CFP59_RS27730	COG0604	alcohol dehydrogenase
CFP59_RS27735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CFP59_RS27740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFP59_RS27750	COG1228	amidohydrolase
CFP59_RS27755	COG1191	sigma factor activity
CFP59_RS27760	COG1366	Belongs to the anti-sigma-factor antagonist family
CFP59_RS27790	COG3104	oligopeptide transport
CFP59_RS27795	COG0745	RESPONSE REGULATOR receiver
CFP59_RS27800	COG2205	protein histidine kinase activity
CFP59_RS27825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CFP59_RS27860	COG1316	TRANSCRIPTIONal
CFP59_RS27865	COG1607	acyl-coa hydrolase
CFP59_RS27870	COG1316	TRANSCRIPTIONal
CFP59_RS27885	COG1316	TRANSCRIPTIONal
CFP59_RS27890	COG1316	TRANSCRIPTIONal
CFP59_RS27915	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CFP59_RS27915	COG0778	Nitroreductase
CFP59_RS27920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CFP59_RS27960	COG1620	l-lactate permease
CFP59_RS27965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFP59_RS27970	COG2835	tetraacyldisaccharide 4'-kinase activity
CFP59_RS27980	COG1482	cell wall glycoprotein biosynthetic process
CFP59_RS27990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFP59_RS27990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFP59_RS27990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CFP59_RS27995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CFP59_RS28030	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CFP59_RS28035	COG0745	RESPONSE REGULATOR receiver
CFP59_RS28040	COG5002	protein histidine kinase activity
CFP59_RS28045	COG0823	Involved in the tonB-independent uptake of proteins
CFP59_RS28055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CFP59_RS28060	COG2197	response regulator
CFP59_RS28065	COG3214	Protein conserved in bacteria
CFP59_RS28075	COG0653	protein targeting
CFP59_RS28095	COG0693	protein deglycase activity
CFP59_RS28100	COG2902	Dehydrogenase
CFP59_RS28105	COG0463	Glycosyl transferase, family 2
CFP59_RS28105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFP59_RS28160	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS28165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CFP59_RS28170	COG0395	ABC-type sugar transport system, permease component
CFP59_RS28175	COG1175	transmembrane transport
CFP59_RS28180	COG1653	transport
CFP59_RS28200	COG0515	serine threonine protein kinase
CFP59_RS28205	COG0515	serine threonine protein kinase
CFP59_RS28210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFP59_RS28225	COG2884	Cell division ATP-binding protein ftsE
CFP59_RS28235	COG0793	Belongs to the peptidase S41A family
CFP59_RS28240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFP59_RS28275	COG0604	alcohol dehydrogenase
CFP59_RS28290	COG2027	D-alanyl-D-alanine carboxypeptidase
CFP59_RS28295	COG1501	Belongs to the glycosyl hydrolase 31 family
CFP59_RS28300	COG0395	ABC-type sugar transport system, permease component
CFP59_RS28315	COG0583	DNA-binding transcription factor activity
CFP59_RS28325	COG0583	DNA-binding transcription factor activity
CFP59_RS28340	COG2223	nitrite transmembrane transporter activity
CFP59_RS28365	COG3973	AAA domain
CFP59_RS28370	COG1278	Cold shock
CFP59_RS28385	COG0776	regulation of translation
CFP59_RS28390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFP59_RS28395	COG1678	Uncharacterized ACR, COG1678
CFP59_RS28415	COG1175	transmembrane transport
CFP59_RS28420	COG0395	ABC-type sugar transport system, permease component
CFP59_RS28425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CFP59_RS28440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS28455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS28470	COG0583	DNA-binding transcription factor activity
CFP59_RS28480	COG2855	membrane
CFP59_RS28495	COG3654	unkown
CFP59_RS28535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CFP59_RS28545	COG0277	FAD linked oxidase domain protein
CFP59_RS28550	COG1064	alcohol dehydrogenase
CFP59_RS28590	COG1335	isochorismatase
CFP59_RS28600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CFP59_RS28610	COG1113	amino acid transport
CFP59_RS28630	COG1234	tRNA 3'-trailer cleavage
CFP59_RS28640	COG2274	protein secretion by the type I secretion system
CFP59_RS28650	COG1263	PTS System
CFP59_RS28655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFP59_RS28660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CFP59_RS28670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFP59_RS28690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFP59_RS28695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFP59_RS28725	COG2733	membrane
CFP59_RS28730	COG3764	Sortase (surface protein transpeptidase)
CFP59_RS28750	COG4702	Belongs to the UPF0303 family
CFP59_RS28755	COG0673	inositol 2-dehydrogenase activity
CFP59_RS28800	COG4585	Histidine kinase
CFP59_RS28805	COG2197	response regulator
CFP59_RS28820	COG2186	Transcriptional regulator
CFP59_RS28850	COG3397	chitin binding
CFP59_RS28885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS28890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFP59_RS28905	COG1063	alcohol dehydrogenase
CFP59_RS28910	COG0477	Major facilitator Superfamily
CFP59_RS28920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFP59_RS28925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS28930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS28945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS28955	COG0300	oxidoreductase activity
CFP59_RS28980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CFP59_RS28985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFP59_RS28995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFP59_RS29000	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS29015	COG4770	biotin carboxylase activity
CFP59_RS29030	COG2267	carboxylic ester hydrolase activity
CFP59_RS29050	COG1126	abc transporter atp-binding protein
CFP59_RS29055	COG0765	amino acid transport
CFP59_RS29060	COG0765	amino acid transport
CFP59_RS29065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFP59_RS29075	COG0154	amidase activity
CFP59_RS29090	COG3473	Maleate cis-trans isomerase
CFP59_RS29110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS29125	COG2197	response regulator
CFP59_RS29130	COG4585	Histidine kinase
CFP59_RS29155	COG4977	sequence-specific DNA binding
CFP59_RS29160	COG0300	oxidoreductase activity
CFP59_RS29240	COG3979	chitinase
CFP59_RS29245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CFP59_RS29275	COG5297	Belongs to the glycosyl hydrolase family 6
CFP59_RS29285	COG4733	cellulase activity
CFP59_RS29285	COG5297	Belongs to the glycosyl hydrolase family 6
CFP59_RS29305	COG0789	Transcriptional regulator
CFP59_RS29310	COG1309	transcriptional regulator
CFP59_RS29415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CFP59_RS29420	COG4977	sequence-specific DNA binding
CFP59_RS29430	COG0589	response to stress
CFP59_RS29435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFP59_RS29455	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS29475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFP59_RS29490	COG1946	Acyl-CoA thioesterase
CFP59_RS29500	COG0513	Belongs to the DEAD box helicase family
CFP59_RS29505	COG1278	Cold shock
CFP59_RS29520	COG0640	Transcriptional regulator
CFP59_RS29540	COG4585	Histidine kinase
CFP59_RS29545	COG2197	response regulator
CFP59_RS29570	COG1472	Belongs to the glycosyl hydrolase 3 family
CFP59_RS29605	COG1846	Transcriptional regulator
CFP59_RS29605	COG0456	acetyltransferase
CFP59_RS29620	COG1609	Transcriptional regulator
CFP59_RS29625	COG0673	inositol 2-dehydrogenase activity
CFP59_RS29645	COG1175	transmembrane transport
CFP59_RS29650	COG0395	ABC-type sugar transport system, permease component
CFP59_RS29665	COG0673	inositol 2-dehydrogenase activity
CFP59_RS29680	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS29685	COG0583	DNA-binding transcription factor activity
CFP59_RS29695	COG1869	D-ribose catabolic process
CFP59_RS29700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS29705	COG1879	ABC-type sugar transport system periplasmic component
CFP59_RS29710	COG1129	ABC transporter
CFP59_RS29715	COG1609	Transcriptional regulator
CFP59_RS29720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFP59_RS29745	COG2409	Drug exporters of the RND superfamily
CFP59_RS29755	COG0673	inositol 2-dehydrogenase activity
CFP59_RS29780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS29790	COG3718	enzyme involved in inositol metabolism
CFP59_RS29795	COG3962	Belongs to the TPP enzyme family
CFP59_RS29825	COG2197	response regulator
CFP59_RS29830	COG4585	Histidine kinase
CFP59_RS29840	COG3402	PFAM membrane-flanked domain
CFP59_RS29855	COG0604	alcohol dehydrogenase
CFP59_RS29855	COG3321	synthase
CFP59_RS29885	COG3321	synthase
CFP59_RS29885	COG0604	alcohol dehydrogenase
CFP59_RS29890	COG3321	synthase
CFP59_RS29890	COG0604	alcohol dehydrogenase
CFP59_RS29935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS29965	COG1215	transferase activity, transferring glycosyl groups
CFP59_RS29970	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS29975	COG1309	transcriptional regulator
CFP59_RS30000	COG1131	(ABC) transporter
CFP59_RS30010	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS30030	COG0583	DNA-binding transcription factor activity
CFP59_RS30035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFP59_RS30040	COG1993	acr, cog1993
CFP59_RS30045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFP59_RS30050	COG0142	geranyltranstransferase activity
CFP59_RS30055	COG3251	PFAM MbtH domain protein
CFP59_RS30065	COG0346	lactoylglutathione lyase activity
CFP59_RS30095	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS30100	COG1309	transcriptional regulator
CFP59_RS30125	COG0629	single-stranded DNA binding
CFP59_RS30160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS30190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFP59_RS30205	COG1486	melibiose metabolic process
CFP59_RS30210	COG0395	ABC-type sugar transport system, permease component
CFP59_RS30215	COG1175	transmembrane transport
CFP59_RS30220	COG1653	transport
CFP59_RS30225	COG1846	Transcriptional regulator
CFP59_RS30225	COG1940	carbohydrate kinase activity
CFP59_RS30235	COG0668	transmembrane transport
CFP59_RS30245	COG3291	Pkd domain containing protein
CFP59_RS30245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CFP59_RS30305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFP59_RS30315	COG1113	amino acid transport
CFP59_RS30330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CFP59_RS30335	COG0235	Class ii aldolase
CFP59_RS30365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS30395	COG1113	amino acid transport
CFP59_RS30400	COG0698	ribose 5-phosphate isomerase
CFP59_RS30410	COG4552	Acetyltransferase involved in intracellular survival and related
CFP59_RS30430	COG3594	Acyltransferase
CFP59_RS30450	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFP59_RS30455	COG0740	serine-type endopeptidase activity
CFP59_RS30460	COG0740	serine-type endopeptidase activity
CFP59_RS30465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFP59_RS30485	COG0525	valine-tRNA ligase activity
CFP59_RS30490	COG0768	penicillin binding
CFP59_RS30495	COG0285	dihydrofolate synthase activity
CFP59_RS30505	COG0105	UTP biosynthetic process
CFP59_RS30510	COG1077	Cell shape determining protein MreB Mrl
CFP59_RS30525	COG0768	penicillin binding
CFP59_RS30535	COG0772	Belongs to the SEDS family
CFP59_RS30555	COG1530	ribonuclease E activity
CFP59_RS30560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFP59_RS30565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CFP59_RS30570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFP59_RS30580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFP59_RS30590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFP59_RS30605	COG0501	Belongs to the peptidase M48B family
CFP59_RS30610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFP59_RS30620	COG0799	negative regulation of ribosome biogenesis
CFP59_RS30625	COG0406	alpha-ribazole phosphatase activity
CFP59_RS30650	COG0495	leucyl-tRNA aminoacylation
CFP59_RS30660	COG1307	EDD domain protein, DegV family
CFP59_RS30665	COG1555	photosystem II stabilization
CFP59_RS30695	COG0268	Binds directly to 16S ribosomal RNA
CFP59_RS30700	COG0481	GTPase activity
CFP59_RS30705	COG1022	Amp-dependent synthetase and ligase
CFP59_RS30730	COG1420	regulation of RNA biosynthetic process
CFP59_RS30735	COG0484	heat shock protein binding
CFP59_RS30750	COG0537	adenosine 5'-monophosphoramidase activity
CFP59_RS30755	COG1234	tRNA 3'-trailer cleavage
CFP59_RS30760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS30770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFP59_RS30790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFP59_RS30805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFP59_RS30815	COG2409	Drug exporters of the RND superfamily
CFP59_RS30820	COG4585	Histidine kinase
CFP59_RS30825	COG2197	response regulator
CFP59_RS30830	COG3422	double-strand break repair
CFP59_RS30880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS30905	COG1381	Involved in DNA repair and RecF pathway recombination
CFP59_RS30910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFP59_RS30915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFP59_RS30940	COG0596	Alpha beta hydrolase
CFP59_RS30975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFP59_RS30980	COG1121	(ABC) transporter
CFP59_RS30990	COG0423	glycine-tRNA ligase activity
CFP59_RS31010	COG2197	response regulator
CFP59_RS31015	COG0477	Major facilitator Superfamily
CFP59_RS31055	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CFP59_RS31060	COG0574	Belongs to the PEP-utilizing enzyme family
CFP59_RS31060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFP59_RS31085	COG0745	RESPONSE REGULATOR receiver
CFP59_RS31100	COG0531	amino acid
CFP59_RS31105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFP59_RS31110	COG2188	Transcriptional regulator
CFP59_RS31115	COG0395	ABC-type sugar transport system, permease component
CFP59_RS31120	COG1175	transmembrane transport
CFP59_RS31125	COG2182	Extracellular solute-binding protein
CFP59_RS31135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFP59_RS31140	COG3485	protocatechuate 3,4-dioxygenase
CFP59_RS31145	COG3485	protocatechuate 3,4-dioxygenase
CFP59_RS31150	COG0183	Belongs to the thiolase family
CFP59_RS31155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CFP59_RS31160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CFP59_RS31165	COG1846	Transcriptional regulator
CFP59_RS31170	COG2890	protein-(glutamine-N5) methyltransferase activity
CFP59_RS31175	COG0300	oxidoreductase activity
CFP59_RS31185	COG1472	Belongs to the glycosyl hydrolase 3 family
CFP59_RS31195	COG1175	transmembrane transport
CFP59_RS31205	COG1609	Transcriptional regulator
CFP59_RS31215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFP59_RS31215	COG2146	nitrite reductase [NAD(P)H] activity
CFP59_RS31230	COG2124	cytochrome p450
CFP59_RS31260	COG2205	protein histidine kinase activity
CFP59_RS31265	COG0745	RESPONSE REGULATOR receiver
CFP59_RS31300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFP59_RS31305	COG0243	molybdopterin cofactor binding
CFP59_RS31315	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CFP59_RS31325	COG0358	DNA primase activity
CFP59_RS31330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFP59_RS31335	COG1070	Carbohydrate kinase
CFP59_RS31365	COG2070	2-Nitropropane dioxygenase
CFP59_RS31395	COG3851	Histidine kinase
CFP59_RS31400	COG2197	response regulator
CFP59_RS31410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFP59_RS31415	COG0395	ABC-type sugar transport system, permease component
CFP59_RS31420	COG1175	transmembrane transport
CFP59_RS31440	COG1486	melibiose metabolic process
CFP59_RS31450	COG2207	Transcriptional regulator
CFP59_RS31455	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS31460	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CFP59_RS31465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS31500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFP59_RS31505	COG0588	phosphoglycerate mutase activity
CFP59_RS31520	COG1414	Transcriptional regulator
CFP59_RS31525	COG3386	PFAM SMP-30 Gluconolaconase
CFP59_RS31540	COG2130	NADP-dependent
CFP59_RS31575	COG4214	carbohydrate transport
CFP59_RS31580	COG1129	ABC transporter
CFP59_RS31600	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS31645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFP59_RS31650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFP59_RS31655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFP59_RS31680	COG0789	Transcriptional regulator
CFP59_RS31685	COG0667	Aldo Keto reductase
CFP59_RS31695	COG2197	response regulator
CFP59_RS31700	COG4585	Histidine kinase
CFP59_RS31715	COG1309	transcriptional regulator
CFP59_RS31720	COG0477	Major facilitator Superfamily
CFP59_RS31730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CFP59_RS31780	COG1358	cellular component organization or biogenesis
CFP59_RS31835	COG1802	Transcriptional regulator
CFP59_RS31840	COG3321	synthase
CFP59_RS31840	COG0604	alcohol dehydrogenase
CFP59_RS31885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFP59_RS31900	COG4106	trans-aconitate 2-methyltransferase activity
CFP59_RS31905	COG3629	intracellular signal transduction
CFP59_RS31905	COG3903	Transcriptional regulator
CFP59_RS31925	COG1309	transcriptional regulator
CFP59_RS31960	COG0740	serine-type endopeptidase activity
CFP59_RS31965	COG0740	serine-type endopeptidase activity
CFP59_RS31995	COG3344	reverse transcriptase
CFP59_RS32045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFP59_RS32075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFP59_RS32095	COG5002	protein histidine kinase activity
CFP59_RS32115	COG0604	alcohol dehydrogenase
CFP59_RS32130	COG2207	Transcriptional regulator
CFP59_RS32150	COG2124	cytochrome p450
CFP59_RS32155	COG0183	Belongs to the thiolase family
CFP59_RS32185	COG3845	ABC transporter
CFP59_RS32230	COG2197	response regulator
CFP59_RS32235	COG1309	transcriptional regulator
CFP59_RS32240	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS32260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS32270	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFP59_RS32275	COG3510	cephalosporin hydroxylase
CFP59_RS32290	COG2030	dehydratase
CFP59_RS32295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CFP59_RS32300	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS32310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFP59_RS32315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFP59_RS32330	COG0800	Aldolase
CFP59_RS32335	COG3022	response to hydroperoxide
CFP59_RS32350	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS32360	COG2409	Drug exporters of the RND superfamily
CFP59_RS32370	COG2197	response regulator
CFP59_RS32390	COG0473	3-isopropylmalate dehydrogenase activity
CFP59_RS32395	COG0583	DNA-binding transcription factor activity
CFP59_RS32400	COG0596	Alpha beta hydrolase
CFP59_RS32430	COG0542	response to heat
CFP59_RS32445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFP59_RS32450	COG0443	Heat shock 70 kDa protein
CFP59_RS32485	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS32490	COG3540	Alkaline phosphatase
CFP59_RS32500	COG2814	Major facilitator Superfamily
CFP59_RS32505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFP59_RS32515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CFP59_RS32540	COG0672	)-iron permease
CFP59_RS32545	COG2837	iron assimilation
CFP59_RS32550	COG2822	iron ion transport
CFP59_RS32555	COG1120	ATPase activity
CFP59_RS32560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS32565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFP59_RS32635	COG1175	transmembrane transport
CFP59_RS32640	COG0395	ABC-type sugar transport system, permease component
CFP59_RS32655	COG1994	Peptidase M50
CFP59_RS32680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFP59_RS32685	COG0477	Major facilitator Superfamily
CFP59_RS32690	COG1309	transcriptional regulator
CFP59_RS32700	COG2814	Major facilitator Superfamily
CFP59_RS32705	COG2267	carboxylic ester hydrolase activity
CFP59_RS32710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFP59_RS32710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFP59_RS32715	COG2132	Multicopper oxidase
CFP59_RS32720	COG0174	glutamine synthetase
CFP59_RS32740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CFP59_RS32765	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
CFP59_RS32775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFP59_RS32780	COG0561	phosphatase activity
CFP59_RS32790	COG1609	Transcriptional regulator
CFP59_RS32795	COG0366	Alpha amylase catalytic
CFP59_RS32800	COG2182	Extracellular solute-binding protein
CFP59_RS32810	COG3833	ABC-type maltose transport systems, permease component
CFP59_RS32840	COG2197	response regulator
CFP59_RS32860	COG0745	RESPONSE REGULATOR receiver
CFP59_RS32875	COG0477	Major facilitator Superfamily
CFP59_RS32895	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CFP59_RS32910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CFP59_RS32920	COG1280	lysine exporter protein (LysE YggA)
CFP59_RS32940	COG0174	glutamine synthetase
CFP59_RS32960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CFP59_RS32965	COG0321	lipoyl(octanoyl) transferase activity
CFP59_RS32975	COG0640	Transcriptional regulator
CFP59_RS33010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CFP59_RS33020	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFP59_RS33025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFP59_RS33030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFP59_RS33040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CFP59_RS33045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CFP59_RS33080	COG4585	Histidine kinase
CFP59_RS33085	COG2197	response regulator
CFP59_RS33090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CFP59_RS33110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFP59_RS33120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFP59_RS33125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFP59_RS33135	COG1376	ErfK ybiS ycfS ynhG family protein
CFP59_RS33145	COG1845	cytochrome c oxidase, subunit III
CFP59_RS33150	COG2010	Cytochrome c
CFP59_RS33155	COG0723	plastoquinol--plastocyanin reductase activity
CFP59_RS33160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CFP59_RS33165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFP59_RS33170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFP59_RS33230	COG0003	Pfam Anion-transporting ATPase
CFP59_RS33240	COG1940	carbohydrate kinase activity
CFP59_RS33275	COG0205	6-phosphofructokinase activity
CFP59_RS33285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CFP59_RS33290	COG0243	molybdopterin cofactor binding
CFP59_RS33295	COG2193	ferroxidase activity
CFP59_RS33300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CFP59_RS33310	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFP59_RS33320	COG0515	serine threonine protein kinase
CFP59_RS33320	COG2815	serine threonine protein kinase
CFP59_RS33330	COG2022	thiamine diphosphate biosynthetic process
CFP59_RS33340	COG2022	thiamine diphosphate biosynthetic process
CFP59_RS33340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFP59_RS33355	COG0352	thiamine-phosphate diphosphorylase activity
CFP59_RS33370	COG1233	COG1233 Phytoene dehydrogenase and related
CFP59_RS33375	COG1309	transcriptional regulator
CFP59_RS33385	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CFP59_RS33415	COG0714	Associated with various cellular activities
CFP59_RS33425	COG0275	rRNA processing
CFP59_RS33440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFP59_RS33445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFP59_RS33450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFP59_RS33455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFP59_RS33465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFP59_RS33470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CFP59_RS33475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFP59_RS33480	COG1496	oxidoreductase activity
CFP59_RS33490	COG1799	cell septum assembly
CFP59_RS33505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFP59_RS33515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFP59_RS33560	COG0587	DNA-directed DNA polymerase activity
CFP59_RS33570	COG1432	Conserved Protein
CFP59_RS33590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CFP59_RS33595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CFP59_RS33605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFP59_RS33610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFP59_RS33615	COG0131	Imidazoleglycerol-phosphate dehydratase
CFP59_RS33620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFP59_RS33625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFP59_RS33630	COG0251	oxidation-reduction process
CFP59_RS33635	COG0107	imidazoleglycerol-phosphate synthase activity
CFP59_RS33640	COG4221	oxidoreductase activity
CFP59_RS33655	COG1120	ATPase activity
CFP59_RS33685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFP59_RS33690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFP59_RS33715	COG0134	indole-3-glycerol-phosphate synthase activity
CFP59_RS33720	COG0133	tryptophan synthase activity
CFP59_RS33725	COG0159	tryptophan synthase activity
CFP59_RS33740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFP59_RS33750	COG0070	glutamate synthase
CFP59_RS33750	COG0069	glutamate synthase activity
CFP59_RS33750	COG0067	glutamate synthase
CFP59_RS33760	COG1725	Transcriptional regulator
CFP59_RS33765	COG1131	(ABC) transporter
CFP59_RS33780	COG3467	pyridoxamine 5'-phosphate
CFP59_RS33800	COG1605	Chorismate mutase
CFP59_RS33800	COG0287	Prephenate dehydrogenase
CFP59_RS33825	COG0737	Belongs to the 5'-nucleotidase family
CFP59_RS33830	COG0494	nUDIX hydrolase
CFP59_RS33865	COG0411	ABC transporter
CFP59_RS33890	COG2050	protein possibly involved in aromatic compounds catabolism
CFP59_RS33930	COG1643	Atp-dependent helicase
CFP59_RS33935	COG2226	methyltransferase
CFP59_RS33960	COG0237	dephospho-CoA kinase activity
CFP59_RS34010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFP59_RS34015	COG0584	glycerophosphoryl diester phosphodiesterase
CFP59_RS34020	COG0556	nucleotide-excision repair
CFP59_RS34040	COG0477	Major facilitator Superfamily
CFP59_RS34055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFP59_RS34065	COG1609	Transcriptional regulator
CFP59_RS34075	COG0322	excinuclease ABC activity
CFP59_RS34080	COG1660	Displays ATPase and GTPase activities
CFP59_RS34085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CFP59_RS34090	COG1481	regulation of sporulation
CFP59_RS34100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFP59_RS34105	COG0126	phosphoglycerate kinase activity
CFP59_RS34110	COG0149	triose-phosphate isomerase activity
CFP59_RS34115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFP59_RS34130	COG0166	Belongs to the GPI family
CFP59_RS34135	COG0363	glucosamine-6-phosphate deaminase activity
CFP59_RS34150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFP59_RS34155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFP59_RS34160	COG0109	protoheme IX farnesyltransferase activity
CFP59_RS34180	COG1612	heme a metabolic process
CFP59_RS34205	COG0719	Fe-S assembly protein
CFP59_RS34215	COG0396	ATPase activity
CFP59_RS34220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFP59_RS34225	COG0822	iron-sulfur transferase activity
CFP59_RS34230	COG2151	metal-sulfur cluster biosynthetic enzyme
CFP59_RS34235	COG2076	Multidrug Resistance protein
CFP59_RS34240	COG3226	Transcriptional regulator
CFP59_RS34245	COG2171	N-acyltransferase activity
CFP59_RS34320	COG0477	Major facilitator Superfamily
CFP59_RS34325	COG1335	isochorismatase
CFP59_RS34330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFP59_RS34335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS34350	COG1802	Transcriptional regulator
CFP59_RS34355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS34370	COG0395	ABC-type sugar transport system, permease component
CFP59_RS34400	COG2252	PERMEase
CFP59_RS34405	COG0667	Aldo Keto reductase
CFP59_RS34415	COG4585	Histidine kinase
CFP59_RS34425	COG1414	Transcriptional regulator
CFP59_RS34435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CFP59_RS34440	COG5285	phytanoyl-CoA dioxygenase
CFP59_RS34445	COG1917	Cupin 2, conserved barrel domain protein
CFP59_RS34455	COG0456	acetyltransferase
CFP59_RS34495	COG1797	cobyrinic acid a,c-diamide synthase activity
CFP59_RS34510	COG1492	cobalamin metabolic process
CFP59_RS34530	COG0235	Class ii aldolase
CFP59_RS34545	COG0488	(ABC) transporter
CFP59_RS34565	COG2205	protein histidine kinase activity
CFP59_RS34565	COG3437	response regulator, receiver
CFP59_RS34565	COG3850	Histidine kinase
CFP59_RS34565	COG4999	Histidine kinase
CFP59_RS34605	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS34610	COG3387	PFAM Glycoside hydrolase 15-related
CFP59_RS34625	COG2176	DNA-directed DNA polymerase activity
CFP59_RS34660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFP59_RS34665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFP59_RS34685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFP59_RS34745	COG1902	pentaerythritol trinitrate reductase activity
CFP59_RS34750	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS34755	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CFP59_RS34765	COG2186	Transcriptional regulator
CFP59_RS34770	COG2807	transmembrane transport
CFP59_RS34785	COG3830	Belongs to the UPF0237 family
CFP59_RS34785	COG0560	Phosphoserine phosphatase
CFP59_RS34795	COG0842	Transport permease protein
CFP59_RS34795	COG1131	(ABC) transporter
CFP59_RS34795	COG1716	ATPase activity
CFP59_RS34800	COG5280	Phage tail tape measure protein TP901
CFP59_RS34800	COG3953	SLT domain
CFP59_RS34805	COG4585	Histidine kinase
CFP59_RS34810	COG2197	response regulator
CFP59_RS34825	COG1119	ATPase activity
CFP59_RS34845	COG1881	PFAM PEBP family protein
CFP59_RS34860	COG2094	Belongs to the DNA glycosylase MPG family
CFP59_RS34900	COG0647	UMP catabolic process
CFP59_RS34905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS34910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS34915	COG1120	ATPase activity
CFP59_RS34940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFP59_RS34945	COG0497	DNA recombination
CFP59_RS34950	COG0297	glycogen (starch) synthase activity
CFP59_RS34965	COG3387	PFAM Glycoside hydrolase 15-related
CFP59_RS34970	COG0504	CTP synthase activity
CFP59_RS34975	COG0494	nUDIX hydrolase
CFP59_RS34980	COG3629	intracellular signal transduction
CFP59_RS34980	COG3903	Transcriptional regulator
CFP59_RS34985	COG0686	Belongs to the AlaDH PNT family
CFP59_RS35000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CFP59_RS35005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CFP59_RS35010	COG1187	pseudouridine synthase activity
CFP59_RS35025	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CFP59_RS35035	COG1160	GTP binding
CFP59_RS35050	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS35065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFP59_RS35115	COG0671	phosphoesterase, PA-phosphatase related
CFP59_RS35125	COG0477	Major facilitator Superfamily
CFP59_RS35130	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS35135	COG1799	cell septum assembly
CFP59_RS35155	COG1126	abc transporter atp-binding protein
CFP59_RS35160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFP59_RS35170	COG0330	HflC and HflK could
CFP59_RS35185	COG3467	pyridoxamine 5'-phosphate
CFP59_RS35190	COG0587	DNA-directed DNA polymerase activity
CFP59_RS35195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFP59_RS35205	COG1764	response to oxidative stress
CFP59_RS35210	COG1846	Transcriptional regulator
CFP59_RS35240	COG0019	diaminopimelate decarboxylase activity
CFP59_RS35265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFP59_RS35265	COG0519	Catalyzes the synthesis of GMP from XMP
CFP59_RS35300	COG2124	cytochrome p450
CFP59_RS35305	COG0596	Alpha beta hydrolase
CFP59_RS35305	COG2226	methyltransferase
CFP59_RS35305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFP59_RS35345	COG1834	amidinotransferase
CFP59_RS35365	COG1649	PFAM Uncharacterised BCR, COG1649
CFP59_RS35365	COG0726	polysaccharide deacetylase
CFP59_RS35380	COG0463	Glycosyl transferase, family 2
CFP59_RS35395	COG2755	lipolytic protein G-D-S-L family
CFP59_RS35400	COG0515	serine threonine protein kinase
CFP59_RS35430	COG2188	Transcriptional regulator
CFP59_RS35435	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CFP59_RS35440	COG1309	transcriptional regulator
CFP59_RS35445	COG0243	molybdopterin cofactor binding
CFP59_RS35450	COG2851	Citrate transporter
CFP59_RS35475	COG2409	Drug exporters of the RND superfamily
CFP59_RS35480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFP59_RS35495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS35510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CFP59_RS35515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CFP59_RS35520	COG0142	geranyltranstransferase activity
CFP59_RS35525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CFP59_RS35530	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CFP59_RS35575	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS35595	COG1733	regulation of RNA biosynthetic process
CFP59_RS35615	COG2149	membrane
CFP59_RS35620	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CFP59_RS35680	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS35700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS35705	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CFP59_RS35710	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS35715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFP59_RS35725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFP59_RS35725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFP59_RS35735	COG0297	glycogen (starch) synthase activity
CFP59_RS35755	COG4221	oxidoreductase activity
CFP59_RS35775	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CFP59_RS35780	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CFP59_RS35785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CFP59_RS35835	COG0667	Aldo Keto reductase
CFP59_RS35840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS35850	COG0598	Magnesium transport protein CorA
CFP59_RS35870	COG0215	cysteine-tRNA ligase activity
CFP59_RS35880	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS35885	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS35895	COG1129	ABC transporter
CFP59_RS35900	COG4211	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS35920	COG2186	Transcriptional regulator
CFP59_RS35930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS35940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS35955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFP59_RS35960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFP59_RS35965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFP59_RS35970	COG1414	Transcriptional regulator
CFP59_RS35975	COG0646	methionine synthase
CFP59_RS35975	COG1410	methionine synthase
CFP59_RS35980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFP59_RS35990	COG2197	response regulator
CFP59_RS36000	COG1994	Peptidase M50
CFP59_RS36000	COG0517	IMP dehydrogenase activity
CFP59_RS36020	COG1222	aaa ATPase
CFP59_RS36025	COG4122	O-methyltransferase activity
CFP59_RS36035	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CFP59_RS36040	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CFP59_RS36045	COG1609	Transcriptional regulator
CFP59_RS36055	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CFP59_RS36060	COG0545	Peptidyl-prolyl cis-trans isomerase
CFP59_RS36070	COG2378	regulation of single-species biofilm formation
CFP59_RS36090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFP59_RS36095	COG0805	protein transport
CFP59_RS36125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFP59_RS36130	COG4175	Glycine betaine
CFP59_RS36130	COG0517	IMP dehydrogenase activity
CFP59_RS36150	COG1309	transcriptional regulator
CFP59_RS36165	COG1228	amidohydrolase
CFP59_RS36170	COG2267	carboxylic ester hydrolase activity
CFP59_RS36175	COG3958	Transketolase
CFP59_RS36180	COG3959	Transketolase, thiamine diphosphate binding domain
CFP59_RS36195	COG2226	methyltransferase
CFP59_RS36200	COG2801	Transposase and inactivated derivatives
CFP59_RS36210	COG1203	CRISPR-associated helicase, Cas3
CFP59_RS36310	COG1518	maintenance of DNA repeat elements
CFP59_RS36315	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CFP59_RS36385	COG1472	Belongs to the glycosyl hydrolase 3 family
CFP59_RS36400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFP59_RS36415	COG0028	Belongs to the TPP enzyme family
CFP59_RS36425	COG0277	FAD linked oxidase domain protein
CFP59_RS36475	COG1063	alcohol dehydrogenase
CFP59_RS36500	COG0531	amino acid
CFP59_RS36515	COG0604	alcohol dehydrogenase
CFP59_RS36535	COG0604	alcohol dehydrogenase
CFP59_RS36535	COG3321	synthase
CFP59_RS36535	COG0604	alcohol dehydrogenase
CFP59_RS36535	COG3321	synthase
CFP59_RS36565	COG3321	synthase
CFP59_RS36565	COG0604	alcohol dehydrogenase
CFP59_RS36580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CFP59_RS36595	COG0546	phosphoglycolate phosphatase activity
CFP59_RS36605	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS36620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CFP59_RS36635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFP59_RS36665	COG0583	DNA-binding transcription factor activity
CFP59_RS36675	COG2186	Transcriptional regulator
CFP59_RS36680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS36695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS36695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CFP59_RS36700	COG1620	l-lactate permease
CFP59_RS36710	COG0583	DNA-binding transcription factor activity
CFP59_RS36715	COG0667	Aldo Keto reductase
CFP59_RS36725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS36730	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS36735	COG1309	transcriptional regulator
CFP59_RS36770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFP59_RS36775	COG1024	Enoyl-CoA hydratase
CFP59_RS36780	COG1024	Enoyl-CoA hydratase
CFP59_RS36805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFP59_RS36825	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS36840	COG2807	transmembrane transport
CFP59_RS36845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFP59_RS36850	COG4770	biotin carboxylase activity
CFP59_RS36875	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CFP59_RS36895	COG1408	metallophosphoesterase
CFP59_RS36920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS36925	COG0702	epimerase
CFP59_RS36935	COG2197	response regulator
CFP59_RS36945	COG0604	alcohol dehydrogenase
CFP59_RS36945	COG3321	synthase
CFP59_RS36950	COG3321	synthase
CFP59_RS36950	COG0604	alcohol dehydrogenase
CFP59_RS37020	COG0477	Major facilitator Superfamily
CFP59_RS37030	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS37055	COG0477	Major facilitator Superfamily
CFP59_RS37080	COG0300	oxidoreductase activity
CFP59_RS37085	COG1082	Xylose isomerase domain protein TIM barrel
CFP59_RS37095	COG2318	DinB family
CFP59_RS37105	COG1396	sequence-specific DNA binding
CFP59_RS37120	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS37130	COG0156	8-amino-7-oxononanoate synthase activity
CFP59_RS37150	COG1316	TRANSCRIPTIONal
CFP59_RS37160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CFP59_RS37165	COG0640	Transcriptional regulator
CFP59_RS37185	COG0069	glutamate synthase activity
CFP59_RS37195	COG4221	oxidoreductase activity
CFP59_RS37205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFP59_RS37210	COG1120	ATPase activity
CFP59_RS37245	COG1716	ATPase activity
CFP59_RS37245	COG1131	(ABC) transporter
CFP59_RS37245	COG0842	Transport permease protein
CFP59_RS37250	COG2409	Drug exporters of the RND superfamily
CFP59_RS37255	COG4585	Histidine kinase
CFP59_RS37270	COG2814	Major facilitator Superfamily
CFP59_RS37295	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS37315	COG0145	ligase activity
CFP59_RS37335	COG0346	lactoylglutathione lyase activity
CFP59_RS37340	COG3458	cephalosporin-C deacetylase activity
CFP59_RS37350	COG4221	oxidoreductase activity
CFP59_RS37365	COG1064	alcohol dehydrogenase
CFP59_RS37380	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS37385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CFP59_RS37395	COG2188	Transcriptional regulator
CFP59_RS37405	COG1175	transmembrane transport
CFP59_RS37415	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS37435	COG2205	protein histidine kinase activity
CFP59_RS37440	COG0745	RESPONSE REGULATOR receiver
CFP59_RS37445	COG3180	Ammonia monooxygenase
CFP59_RS37455	COG0745	RESPONSE REGULATOR receiver
CFP59_RS37490	COG0730	response to heat
CFP59_RS37495	COG1937	Protein conserved in bacteria
CFP59_RS37500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFP59_RS37515	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS37525	COG2124	cytochrome p450
CFP59_RS37545	COG0402	S-adenosylhomocysteine deaminase activity
CFP59_RS37565	COG0702	epimerase
CFP59_RS37575	COG1309	transcriptional regulator
CFP59_RS37580	COG0583	DNA-binding transcription factor activity
CFP59_RS37585	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS37615	COG2824	Alkylphosphonate utilization operon protein PhnA
CFP59_RS37635	COG0583	DNA-binding transcription factor activity
CFP59_RS37680	COG2197	response regulator
CFP59_RS37685	COG3850	Histidine kinase
CFP59_RS37715	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS37745	COG1233	COG1233 Phytoene dehydrogenase and related
CFP59_RS37770	COG0596	Alpha beta hydrolase
CFP59_RS37780	COG2072	flavoprotein involved in K transport
CFP59_RS37805	COG0583	DNA-binding transcription factor activity
CFP59_RS37820	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS37830	COG0583	DNA-binding transcription factor activity
CFP59_RS37835	COG4977	sequence-specific DNA binding
CFP59_RS37840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CFP59_RS37860	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS37865	COG1968	undecaprenyl-diphosphatase activity
CFP59_RS37890	COG0154	amidase activity
CFP59_RS37895	COG1309	transcriptional regulator
CFP59_RS37900	COG1802	Transcriptional regulator
CFP59_RS37905	COG0436	Aminotransferase
CFP59_RS38005	COG0300	oxidoreductase activity
CFP59_RS38020	COG4941	Belongs to the sigma-70 factor family
CFP59_RS38025	COG3795	YCII-related domain
CFP59_RS38035	COG0588	phosphoglycerate mutase activity
CFP59_RS38040	COG1070	Carbohydrate kinase
CFP59_RS38045	COG1070	Carbohydrate kinase
CFP59_RS38050	COG1349	DNA-binding transcription factor activity
CFP59_RS38060	COG2814	Major facilitator Superfamily
CFP59_RS38065	COG1349	DNA-binding transcription factor activity
CFP59_RS38070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFP59_RS38085	COG2376	Dihydroxyacetone kinase
CFP59_RS38090	COG0698	ribose 5-phosphate isomerase
CFP59_RS38150	COG0673	inositol 2-dehydrogenase activity
CFP59_RS38160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFP59_RS38165	COG4209	transmembrane transport
CFP59_RS38170	COG0395	ABC-type sugar transport system, permease component
CFP59_RS38205	COG3469	chitinase activity
CFP59_RS38245	COG3469	chitinase activity
CFP59_RS38255	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS38270	COG1129	ABC transporter
CFP59_RS38275	COG1802	Transcriptional regulator
CFP59_RS38290	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS38330	COG2197	response regulator
CFP59_RS38365	COG0277	FAD linked oxidase domain protein
CFP59_RS38375	COG1309	transcriptional regulator
CFP59_RS38390	COG1309	transcriptional regulator
CFP59_RS38400	COG2205	protein histidine kinase activity
CFP59_RS38405	COG0745	RESPONSE REGULATOR receiver
CFP59_RS38420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS38425	COG1116	anion transmembrane transporter activity
CFP59_RS38435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS38440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS38460	COG3971	2-oxopent-4-enoate hydratase activity
CFP59_RS38480	COG0515	serine threonine protein kinase
CFP59_RS38500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CFP59_RS38505	COG1595	DNA-templated transcription, initiation
CFP59_RS38515	COG0243	molybdopterin cofactor binding
CFP59_RS38545	COG2267	carboxylic ester hydrolase activity
CFP59_RS38555	COG0596	Alpha beta hydrolase
CFP59_RS38565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS38580	COG0251	oxidation-reduction process
CFP59_RS38595	COG3961	Belongs to the TPP enzyme family
CFP59_RS38600	COG1231	oxidoreductase activity
CFP59_RS38615	COG0583	DNA-binding transcription factor activity
CFP59_RS38625	COG2814	Major facilitator Superfamily
CFP59_RS38635	COG0656	L-ascorbic acid biosynthetic process
CFP59_RS38650	COG1902	pentaerythritol trinitrate reductase activity
CFP59_RS38675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFP59_RS38690	COG2226	methyltransferase
CFP59_RS38710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CFP59_RS38715	COG0395	ABC-type sugar transport system, permease component
CFP59_RS38720	COG1175	transmembrane transport
CFP59_RS38730	COG1414	Transcriptional regulator
CFP59_RS38750	COG1940	carbohydrate kinase activity
CFP59_RS38770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFP59_RS38775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFP59_RS38780	COG2188	Transcriptional regulator
CFP59_RS38790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFP59_RS38795	COG1131	(ABC) transporter
CFP59_RS38805	COG3850	Histidine kinase
CFP59_RS38830	COG2326	polyphosphate kinase activity
CFP59_RS38835	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CFP59_RS38845	COG3639	organic phosphonate transmembrane transporter activity
CFP59_RS38860	COG3119	arylsulfatase activity
CFP59_RS38865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS38915	COG1116	anion transmembrane transporter activity
CFP59_RS38920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS38930	COG2027	D-alanyl-D-alanine carboxypeptidase
CFP59_RS38950	COG2706	6-phosphogluconolactonase activity
CFP59_RS38970	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFP59_RS38980	COG1902	pentaerythritol trinitrate reductase activity
CFP59_RS38985	COG0640	Transcriptional regulator
CFP59_RS38990	COG2233	PERMEase
CFP59_RS39010	COG1309	transcriptional regulator
CFP59_RS39050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS39060	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS39090	COG3321	synthase
CFP59_RS39090	COG0604	alcohol dehydrogenase
CFP59_RS39100	COG0604	alcohol dehydrogenase
CFP59_RS39100	COG3321	synthase
CFP59_RS39105	COG0596	Alpha beta hydrolase
CFP59_RS39110	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFP59_RS39120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CFP59_RS39140	COG4166	transmembrane transport
CFP59_RS39145	COG0601	transmembrane transport
CFP59_RS39150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS39155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFP59_RS39195	COG2070	2-Nitropropane dioxygenase
CFP59_RS39200	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS39205	COG1024	Enoyl-CoA hydratase
CFP59_RS39215	COG1024	Enoyl-CoA hydratase
CFP59_RS39220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFP59_RS39225	COG1846	Transcriptional regulator
CFP59_RS39230	COG2271	Major facilitator Superfamily
CFP59_RS39235	COG0671	phosphoesterase, PA-phosphatase related
CFP59_RS39265	COG0584	glycerophosphoryl diester phosphodiesterase
CFP59_RS39305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFP59_RS39355	COG3345	alpha-galactosidase
CFP59_RS39365	COG1175	transmembrane transport
CFP59_RS39370	COG0395	ABC-type sugar transport system, permease component
CFP59_RS39375	COG1660	Displays ATPase and GTPase activities
CFP59_RS39385	COG0445	tRNA wobble uridine modification
CFP59_RS39395	COG4585	Histidine kinase
CFP59_RS39400	COG2197	response regulator
CFP59_RS39430	COG1940	carbohydrate kinase activity
CFP59_RS39465	COG1349	DNA-binding transcription factor activity
CFP59_RS39475	COG0464	growth
CFP59_RS39525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFP59_RS39540	COG0494	nUDIX hydrolase
CFP59_RS39545	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS39570	COG2124	cytochrome p450
CFP59_RS39575	COG2124	cytochrome p450
CFP59_RS39585	COG0142	geranyltranstransferase activity
CFP59_RS39590	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CFP59_RS39590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFP59_RS39590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFP59_RS39595	COG1461	Dihydroxyacetone kinase
CFP59_RS39600	COG2376	Dihydroxyacetone kinase
CFP59_RS39610	COG1960	acyl-CoA dehydrogenase activity
CFP59_RS39615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFP59_RS39640	COG0515	serine threonine protein kinase
CFP59_RS39640	COG2815	serine threonine protein kinase
CFP59_RS39650	COG2070	2-Nitropropane dioxygenase
CFP59_RS39745	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS39750	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS39780	COG1984	allophanate hydrolase subunit 2
CFP59_RS39785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CFP59_RS39790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CFP59_RS39810	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CFP59_RS39835	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS39840	COG4638	Rieske (2fe-2S)
CFP59_RS39865	COG2146	nitrite reductase [NAD(P)H] activity
CFP59_RS39885	COG2018	Roadblock/LC7 domain
CFP59_RS39900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFP59_RS39905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFP59_RS39920	COG3842	ATPase activity
CFP59_RS39925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CFP59_RS39930	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFP59_RS39935	COG1177	transmembrane transport
CFP59_RS39940	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CFP59_RS39950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFP59_RS39975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFP59_RS40010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CFP59_RS40050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFP59_RS40060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFP59_RS40060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFP59_RS40085	COG0384	phenazine biosynthesis protein PhzF
CFP59_RS40125	COG0583	DNA-binding transcription factor activity
CFP59_RS40145	COG0488	(ABC) transporter
CFP59_RS40170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFP59_RS40180	COG2378	regulation of single-species biofilm formation
CFP59_RS40190	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS40215	COG0596	Alpha beta hydrolase
CFP59_RS40220	COG1335	isochorismatase
CFP59_RS40245	COG0477	Major facilitator Superfamily
CFP59_RS40250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS40255	COG2309	aminopeptidase activity
CFP59_RS40260	COG2318	DinB family
CFP59_RS40295	COG2186	Transcriptional regulator
CFP59_RS40300	COG1113	amino acid transport
CFP59_RS40350	COG1024	Enoyl-CoA hydratase
CFP59_RS40355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFP59_RS40360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFP59_RS40365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFP59_RS40370	COG0254	rRNA binding
CFP59_RS40380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFP59_RS40430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CFP59_RS40445	COG0583	DNA-binding transcription factor activity
CFP59_RS40465	COG1309	transcriptional regulator
CFP59_RS40470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CFP59_RS40475	COG1819	glycosyl
CFP59_RS40480	COG0477	Major facilitator Superfamily
CFP59_RS40485	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS40495	COG2261	transglycosylase associated protein
CFP59_RS40500	COG1316	TRANSCRIPTIONal
CFP59_RS40580	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS40605	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS40615	COG0431	NADPH-dependent FMN reductase
CFP59_RS40620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS40640	COG4585	Histidine kinase
CFP59_RS40645	COG2197	response regulator
CFP59_RS40650	COG1136	(ABC) transporter
CFP59_RS40650	COG0577	efflux transmembrane transporter activity
CFP59_RS40655	COG1136	(ABC) transporter
CFP59_RS40655	COG0577	efflux transmembrane transporter activity
CFP59_RS40685	COG2353	YceI-like domain
CFP59_RS40700	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS40710	COG0137	argininosuccinate synthase activity
CFP59_RS40720	COG0366	Alpha amylase catalytic
CFP59_RS40725	COG0395	ABC-type sugar transport system, permease component
CFP59_RS40730	COG1175	transmembrane transport
CFP59_RS40770	COG0604	alcohol dehydrogenase
CFP59_RS40770	COG3321	synthase
CFP59_RS40885	COG0587	DNA-directed DNA polymerase activity
CFP59_RS40925	COG3467	pyridoxamine 5'-phosphate
CFP59_RS40945	COG5006	permease, DMT superfamily
CFP59_RS40960	COG0789	Transcriptional regulator
CFP59_RS41020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFP59_RS41025	COG1053	succinate dehydrogenase
CFP59_RS41040	COG2072	flavoprotein involved in K transport
CFP59_RS41050	COG1063	alcohol dehydrogenase
CFP59_RS41055	COG0778	Nitroreductase
CFP59_RS41060	COG2197	response regulator
CFP59_RS41065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS41070	COG0604	alcohol dehydrogenase
CFP59_RS41070	COG3321	synthase
CFP59_RS41080	COG3321	synthase
CFP59_RS41080	COG0604	alcohol dehydrogenase
CFP59_RS41095	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CFP59_RS41120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFP59_RS41130	COG3290	protein histidine kinase activity
CFP59_RS41160	COG0546	phosphoglycolate phosphatase activity
CFP59_RS41175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CFP59_RS41185	COG0789	Transcriptional regulator
CFP59_RS41220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFP59_RS41220	COG0515	serine threonine protein kinase
CFP59_RS41230	COG0542	response to heat
CFP59_RS41260	COG5001	Diguanylate cyclase
CFP59_RS41260	COG3300	MHYT domain
CFP59_RS41270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CFP59_RS41305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFP59_RS41315	COG4977	sequence-specific DNA binding
CFP59_RS41335	COG0431	NADPH-dependent FMN reductase
CFP59_RS41390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CFP59_RS41395	COG0515	serine threonine protein kinase
CFP59_RS41395	COG2815	serine threonine protein kinase
CFP59_RS41405	COG1294	oxidase, subunit
CFP59_RS41410	COG1271	oxidase subunit
CFP59_RS41415	COG0577	efflux transmembrane transporter activity
CFP59_RS41425	COG2197	response regulator
CFP59_RS41450	COG0673	inositol 2-dehydrogenase activity
CFP59_RS41460	COG1609	Transcriptional regulator
CFP59_RS41465	COG0395	ABC-type sugar transport system, permease component
CFP59_RS41470	COG1175	transmembrane transport
CFP59_RS41490	COG3507	Belongs to the glycosyl hydrolase 43 family
CFP59_RS41495	COG3119	arylsulfatase activity
CFP59_RS41520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CFP59_RS41545	COG0531	amino acid
CFP59_RS41560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CFP59_RS41575	COG1309	transcriptional regulator
CFP59_RS41600	COG2197	response regulator
CFP59_RS41610	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS41615	COG0475	glutathione-regulated potassium exporter activity
CFP59_RS41630	COG0492	ferredoxin-NADP+ reductase activity
CFP59_RS41635	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS41660	COG1609	Transcriptional regulator
CFP59_RS41665	COG0673	inositol 2-dehydrogenase activity
CFP59_RS41670	COG0701	Predicted permease
CFP59_RS41685	COG0129	dihydroxy-acid dehydratase activity
CFP59_RS41690	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS41695	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS41735	COG2271	Major facilitator Superfamily
CFP59_RS41745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CFP59_RS41755	COG2226	methyltransferase
CFP59_RS41760	COG3835	regulator
CFP59_RS41785	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS41800	COG3509	depolymerase
CFP59_RS41805	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS41815	COG0156	8-amino-7-oxononanoate synthase activity
CFP59_RS41895	COG0656	L-ascorbic acid biosynthetic process
CFP59_RS41910	COG0488	(ABC) transporter
CFP59_RS41935	COG1819	glycosyl
CFP59_RS41945	COG0701	Predicted permease
CFP59_RS41955	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS41960	COG1472	Belongs to the glycosyl hydrolase 3 family
CFP59_RS41985	COG0435	Glutathione S-transferase
CFP59_RS42010	COG0477	Major facilitator Superfamily
CFP59_RS42020	COG2340	Cysteine-rich secretory protein family
CFP59_RS42030	COG1064	alcohol dehydrogenase
CFP59_RS42045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFP59_RS42070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CFP59_RS42070	COG3291	Pkd domain containing protein
CFP59_RS42145	COG4221	oxidoreductase activity
CFP59_RS42155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CFP59_RS42175	COG1902	pentaerythritol trinitrate reductase activity
CFP59_RS42180	COG1968	undecaprenyl-diphosphatase activity
CFP59_RS42190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFP59_RS42195	COG1414	Transcriptional regulator
CFP59_RS42220	COG2610	gluconate transmembrane transporter activity
CFP59_RS42225	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS42260	COG3537	Alpha-1,2-mannosidase
CFP59_RS42275	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CFP59_RS42290	COG3387	PFAM Glycoside hydrolase 15-related
CFP59_RS42320	COG2197	response regulator
CFP59_RS42325	COG0668	transmembrane transport
CFP59_RS42330	COG2814	Major facilitator Superfamily
CFP59_RS42350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFP59_RS42355	COG0142	geranyltranstransferase activity
CFP59_RS42370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS42375	COG2175	clavaminate synthase activity
CFP59_RS42385	COG0739	heme binding
CFP59_RS42395	COG2508	Transcriptional regulator
CFP59_RS42405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFP59_RS42420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CFP59_RS42430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFP59_RS42455	COG0326	Molecular chaperone. Has ATPase activity
CFP59_RS42475	COG0412	Dienelactone hydrolase
CFP59_RS42505	COG0515	serine threonine protein kinase
CFP59_RS42505	COG2815	serine threonine protein kinase
CFP59_RS42545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFP59_RS42550	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS42555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CFP59_RS42560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS42570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS42590	COG0601	transmembrane transport
CFP59_RS42635	COG3594	Acyltransferase
CFP59_RS42640	COG2376	Dihydroxyacetone kinase
CFP59_RS42645	COG2376	Dihydroxyacetone kinase
CFP59_RS42650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CFP59_RS42655	COG4221	oxidoreductase activity
CFP59_RS42690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFP59_RS42700	COG4565	transcriptional regulatory protein
CFP59_RS42705	COG3290	protein histidine kinase activity
CFP59_RS42715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS42720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFP59_RS42725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFP59_RS42740	COG0726	polysaccharide deacetylase
CFP59_RS42745	COG0114	fumarate hydratase activity
CFP59_RS42755	COG2267	carboxylic ester hydrolase activity
CFP59_RS42770	COG3629	intracellular signal transduction
CFP59_RS42770	COG3903	Transcriptional regulator
CFP59_RS42775	COG2175	clavaminate synthase activity
CFP59_RS42780	COG0583	DNA-binding transcription factor activity
CFP59_RS42800	COG0306	phosphate transporter
CFP59_RS42810	COG1357	PFAM Pentapeptide repeats (8 copies)
CFP59_RS42845	COG1131	(ABC) transporter
CFP59_RS42875	COG3511	phospholipase C
CFP59_RS42900	COG1051	belongs to the nudix hydrolase family
CFP59_RS42955	COG2356	endonuclease I
CFP59_RS42960	COG0328	RNA-DNA hybrid ribonuclease activity
CFP59_RS43005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFP59_RS43010	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CFP59_RS43015	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS43040	COG1982	Orn Lys Arg decarboxylase major
CFP59_RS43055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFP59_RS43085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFP59_RS43120	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFP59_RS43130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CFP59_RS43155	COG0477	Major facilitator Superfamily
CFP59_RS43195	COG0667	Aldo Keto reductase
CFP59_RS43205	COG0789	Transcriptional regulator
CFP59_RS43215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFP59_RS43220	COG1017	nitric oxide dioxygenase activity
CFP59_RS43220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFP59_RS43225	COG1959	2 iron, 2 sulfur cluster binding
CFP59_RS43275	COG0667	Aldo Keto reductase
CFP59_RS43280	COG2318	DinB family
CFP59_RS43290	COG2186	Transcriptional regulator
CFP59_RS43295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFP59_RS43300	COG3622	Belongs to the hyi family
CFP59_RS43310	COG3395	kinase activity
CFP59_RS43315	COG2084	Dehydrogenase
CFP59_RS43325	COG0583	DNA-binding transcription factor activity
CFP59_RS43405	COG2353	YceI-like domain
CFP59_RS43415	COG1733	regulation of RNA biosynthetic process
CFP59_RS43420	COG0753	catalase activity
CFP59_RS43425	COG2814	Major facilitator Superfamily
CFP59_RS43455	COG4977	sequence-specific DNA binding
CFP59_RS43470	COG0300	oxidoreductase activity
CFP59_RS43470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS43470	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS43470	COG3321	synthase
CFP59_RS43470	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS43490	COG2192	nodulation
CFP59_RS43520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFP59_RS43540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFP59_RS43540	COG0723	plastoquinol--plastocyanin reductase activity
CFP59_RS43550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFP59_RS43555	COG2890	protein-(glutamine-N5) methyltransferase activity
CFP59_RS43565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFP59_RS43645	COG3454	Phosphonate metabolism
CFP59_RS43650	COG4598	ABC transporter
CFP59_RS43655	COG3627	carbon phosphorus lyase activity
CFP59_RS43660	COG3626	phosphonate metabolism
CFP59_RS43680	COG3961	Belongs to the TPP enzyme family
CFP59_RS43690	COG0477	Major facilitator Superfamily
CFP59_RS43715	COG3246	L-lysine catabolic process to acetate
CFP59_RS43725	COG4335	DNA alkylation repair
CFP59_RS43730	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS43735	COG1733	regulation of RNA biosynthetic process
CFP59_RS43765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS43780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS43785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS43790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS43795	COG0747	negative chemotaxis
CFP59_RS43800	COG0601	transmembrane transport
CFP59_RS43805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS43810	COG4172	Belongs to the ABC transporter superfamily
CFP59_RS43845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS43865	COG1473	amidohydrolase
CFP59_RS43870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFP59_RS43885	COG1177	transmembrane transport
CFP59_RS43890	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFP59_RS43895	COG3842	ATPase activity
CFP59_RS43905	COG0747	negative chemotaxis
CFP59_RS43910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS43920	COG4172	Belongs to the ABC transporter superfamily
CFP59_RS43925	COG2175	clavaminate synthase activity
CFP59_RS43935	COG0667	Aldo Keto reductase
CFP59_RS43940	COG1309	transcriptional regulator
CFP59_RS43975	COG4977	sequence-specific DNA binding
CFP59_RS43975	COG1917	Cupin 2, conserved barrel domain protein
CFP59_RS43985	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFP59_RS44015	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS44025	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS44040	COG3284	Transcriptional regulator
CFP59_RS44045	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS44065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFP59_RS44130	COG2197	response regulator
CFP59_RS44205	COG2409	Drug exporters of the RND superfamily
CFP59_RS44265	COG2197	response regulator
CFP59_RS44285	COG0477	Major facilitator Superfamily
CFP59_RS44300	COG4106	trans-aconitate 2-methyltransferase activity
CFP59_RS44330	COG1414	Transcriptional regulator
CFP59_RS44335	COG5006	permease, DMT superfamily
CFP59_RS44340	COG0583	DNA-binding transcription factor activity
CFP59_RS44405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFP59_RS44425	COG1073	alpha beta
CFP59_RS44440	COG0300	oxidoreductase activity
CFP59_RS44445	COG0454	-acetyltransferase
CFP59_RS44445	COG0456	acetyltransferase
CFP59_RS44480	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFP59_RS44485	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS44490	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS44525	COG0640	Transcriptional regulator
CFP59_RS44560	COG1929	Belongs to the glycerate kinase type-1 family
CFP59_RS44570	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS44580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFP59_RS44615	COG1024	Enoyl-CoA hydratase
CFP59_RS44620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS44670	COG0395	ABC-type sugar transport system, permease component
CFP59_RS44675	COG1175	transmembrane transport
CFP59_RS44700	COG1609	Transcriptional regulator
CFP59_RS44715	COG0477	Major facilitator Superfamily
CFP59_RS44725	COG1609	Transcriptional regulator
CFP59_RS44745	COG0789	Transcriptional regulator
CFP59_RS44760	COG4154	Belongs to the RbsD FucU family
CFP59_RS44780	COG1609	Transcriptional regulator
CFP59_RS44785	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS44790	COG0583	DNA-binding transcription factor activity
CFP59_RS44795	COG2195	Cleaves the N-terminal amino acid of tripeptides
CFP59_RS44810	COG0601	transmembrane transport
CFP59_RS44815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFP59_RS44825	COG4608	Belongs to the ABC transporter superfamily
CFP59_RS44835	COG2409	Drug exporters of the RND superfamily
CFP59_RS44845	COG1309	transcriptional regulator
CFP59_RS44850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CFP59_RS44855	COG1802	Transcriptional regulator
CFP59_RS44860	COG1017	nitric oxide dioxygenase activity
CFP59_RS44860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CFP59_RS44865	COG2423	ornithine cyclodeaminase activity
CFP59_RS44870	COG2031	fatty acid transporter
CFP59_RS44875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFP59_RS44920	COG0583	DNA-binding transcription factor activity
CFP59_RS44945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFP59_RS44945	COG0519	Catalyzes the synthesis of GMP from XMP
CFP59_RS44970	COG0477	Major facilitator Superfamily
CFP59_RS44985	COG2226	methyltransferase
CFP59_RS45010	COG2207	Transcriptional regulator
CFP59_RS45015	COG0604	alcohol dehydrogenase
CFP59_RS45020	COG1733	regulation of RNA biosynthetic process
CFP59_RS45025	COG0154	amidase activity
CFP59_RS45055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFP59_RS45060	COG0531	amino acid
CFP59_RS45065	COG1349	DNA-binding transcription factor activity
CFP59_RS45095	COG3454	Phosphonate metabolism
CFP59_RS45100	COG1126	abc transporter atp-binding protein
CFP59_RS45135	COG3639	organic phosphonate transmembrane transporter activity
CFP59_RS45140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CFP59_RS45145	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CFP59_RS45150	COG3104	oligopeptide transport
CFP59_RS45165	COG0395	ABC-type sugar transport system, permease component
CFP59_RS45170	COG1175	transmembrane transport
CFP59_RS45190	COG1486	melibiose metabolic process
CFP59_RS45195	COG0363	glucosamine-6-phosphate deaminase activity
CFP59_RS45215	COG3293	Transposase
CFP59_RS45220	COG0477	Major facilitator Superfamily
CFP59_RS45225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFP59_RS45230	COG0028	Belongs to the TPP enzyme family
CFP59_RS45240	COG1653	transport
CFP59_RS45245	COG0395	ABC-type sugar transport system, permease component
CFP59_RS45250	COG1175	transmembrane transport
CFP59_RS45255	COG3842	ATPase activity
CFP59_RS45260	COG3608	succinylglutamate desuccinylase aspartoacylase
CFP59_RS45270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFP59_RS45280	COG0436	Aminotransferase
CFP59_RS45290	COG1737	Transcriptional regulator
CFP59_RS45305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFP59_RS45315	COG1737	Transcriptional regulator
CFP59_RS45320	COG0765	amino acid transport
CFP59_RS45325	COG1126	abc transporter atp-binding protein
CFP59_RS45340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS45345	COG1414	Transcriptional regulator
CFP59_RS45350	COG0477	Major facilitator Superfamily
CFP59_RS45370	COG1522	sequence-specific DNA binding
CFP59_RS45375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CFP59_RS45380	COG2755	lipolytic protein G-D-S-L family
CFP59_RS45405	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFP59_RS45435	COG1914	H( )-stimulated, divalent metal cation uptake system
CFP59_RS45450	COG3250	beta-galactosidase activity
CFP59_RS45455	COG4106	trans-aconitate 2-methyltransferase activity
CFP59_RS45485	COG0537	adenosine 5'-monophosphoramidase activity
CFP59_RS45530	COG1116	anion transmembrane transporter activity
CFP59_RS45535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFP59_RS45625	COG4585	Histidine kinase
CFP59_RS45630	COG2197	response regulator
CFP59_RS45660	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFP59_RS45695	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFP59_RS45705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS45715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS45750	COG1091	dTDP-4-dehydrorhamnose reductase activity
CFP59_RS45760	COG0596	Alpha beta hydrolase
CFP59_RS45775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFP59_RS45810	COG2801	Transposase and inactivated derivatives
CFP59_RS45820	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CFP59_RS45835	COG2197	response regulator
CFP59_RS45840	COG4585	Histidine kinase
CFP59_RS45870	COG1309	transcriptional regulator
CFP59_RS45880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFP59_RS45945	COG2770	Histidine kinase
CFP59_RS45945	COG2208	phosphoserine phosphatase activity
CFP59_RS45950	COG1609	Transcriptional regulator
CFP59_RS45955	COG1879	ABC-type sugar transport system periplasmic component
CFP59_RS45960	COG1129	ABC transporter
CFP59_RS45965	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFP59_RS46010	COG0129	dihydroxy-acid dehydratase activity
CFP59_RS46015	COG3387	PFAM Glycoside hydrolase 15-related
CFP59_RS46020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFP59_RS46040	COG1929	Belongs to the glycerate kinase type-1 family
CFP59_RS46045	COG3960	tartronate-semialdehyde synthase activity
CFP59_RS46050	COG2084	Dehydrogenase
CFP59_RS46055	COG3622	Belongs to the hyi family
CFP59_RS46065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CFP59_RS46075	COG1414	Transcriptional regulator
CFP59_RS46080	COG1953	Uracil, thiamine, allantoin
CFP59_RS46090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFP59_RS46095	COG4266	Belongs to the allantoicase family
CFP59_RS46105	COG3693	PFAM glycoside hydrolase, family 10
CFP59_RS46115	COG1609	Transcriptional regulator
CFP59_RS46125	COG1175	transmembrane transport
CFP59_RS46140	COG1472	Belongs to the glycosyl hydrolase 3 family
CFP59_RS46145	COG1228	amidohydrolase
CFP59_RS46165	COG0765	amino acid transport
CFP59_RS46190	COG2192	nodulation
CFP59_RS46195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFP59_RS46220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFP59_RS46230	COG0477	Major facilitator Superfamily
CFP59_RS46235	COG0585	pseudouridine synthase activity
CFP59_RS46240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFP59_RS46250	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFP59_RS46285	COG0156	8-amino-7-oxononanoate synthase activity
CFP59_RS46340	COG3321	synthase
CFP59_RS46340	COG0604	alcohol dehydrogenase
CFP59_RS46355	COG3321	synthase
CFP59_RS46355	COG0604	alcohol dehydrogenase
CFP59_RS46405	COG3321	synthase
CFP59_RS46405	COG0604	alcohol dehydrogenase
CFP59_RS46410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CFP59_RS46465	COG0604	alcohol dehydrogenase
CFP59_RS46465	COG3321	synthase
CFP59_RS46470	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CFP59_RS46490	COG3619	membrane
CFP59_RS46500	COG1012	belongs to the aldehyde dehydrogenase family
CFP59_RS46505	COG2508	Transcriptional regulator
CFP59_RS46525	COG3069	C4-dicarboxylate transmembrane transporter activity
CFP59_RS46550	COG2815	serine threonine protein kinase
CFP59_RS46550	COG0515	serine threonine protein kinase
CFP59_RS46580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFP59_RS46585	COG0477	Major facilitator Superfamily
CFP59_RS46590	COG2376	Dihydroxyacetone kinase
CFP59_RS46595	COG2376	Dihydroxyacetone kinase
CFP59_RS46630	COG0640	Transcriptional regulator
CFP59_RS46635	COG0346	lactoylglutathione lyase activity
CFP59_RS46655	COG3321	synthase
CFP59_RS46655	COG0604	alcohol dehydrogenase
CFP59_RS46655	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS46680	COG2132	Multicopper oxidase
CFP59_RS46690	COG2301	Belongs to the HpcH HpaI aldolase family
CFP59_RS46695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CFP59_RS46700	COG1802	Transcriptional regulator
CFP59_RS46735	COG0583	DNA-binding transcription factor activity
CFP59_RS46740	COG0300	oxidoreductase activity
CFP59_RS46780	COG1309	transcriptional regulator
CFP59_RS46815	COG1609	Transcriptional regulator
CFP59_RS46830	COG1414	Transcriptional regulator
CFP59_RS46855	COG1028	Short-chain dehydrogenase reductase Sdr
CFP59_RS46865	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS46875	COG1309	transcriptional regulator
CFP59_RS46915	COG1121	(ABC) transporter
CFP59_RS46920	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFP59_RS46935	COG0601	transmembrane transport
CFP59_RS46940	COG4171	peptide transport system, permease
CFP59_RS46950	COG1021	2,3-dihydroxybenzoate-AMP ligase
CFP59_RS46955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS46955	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CFP59_RS46960	COG3433	isochorismatase activity
CFP59_RS46960	COG2226	methyltransferase
CFP59_RS46960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS46975	COG2124	cytochrome p450
CFP59_RS46990	COG2375	cellular response to nickel ion
CFP59_RS46990	COG1132	(ABC) transporter
CFP59_RS46995	COG1132	(ABC) transporter
CFP59_RS47000	COG1169	isochorismate synthase
CFP59_RS47010	COG0523	cobalamin synthesis protein
CFP59_RS47025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFP59_RS47030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFP59_RS47035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFP59_RS47040	COG0254	rRNA binding
CFP59_RS47050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFP59_RS47055	COG0640	Transcriptional regulator
CFP59_RS47070	COG0523	cobalamin synthesis protein
CFP59_RS47105	COG0649	NAD binding
CFP59_RS47145	COG2813	Specifically methylates the guanine in position
CFP59_RS47165	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFP59_RS47175	COG1121	(ABC) transporter
CFP59_RS47180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFP59_RS47235	COG4221	oxidoreductase activity
CFP59_RS47250	COG2837	iron assimilation
CFP59_RS47255	COG0109	protoheme IX farnesyltransferase activity
CFP59_RS47300	COG0318	PFAM AMP-dependent synthetase and ligase
CFP59_RS47320	COG3253	May function as heme-dependent peroxidase
CFP59_RS47365	COG1309	transcriptional regulator
CFP59_RS47390	COG0438	transferase activity, transferring glycosyl groups
CFP59_RS47415	COG3507	Belongs to the glycosyl hydrolase 43 family
CFP59_RS47420	COG3345	alpha-galactosidase
CFP59_RS47455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFP59_RS47490	COG1794	racemase activity, acting on amino acids and derivatives
CFP59_RS47500	COG4221	oxidoreductase activity
CFP59_RS47530	COG3293	Transposase
CFP59_RS47540	COG1733	regulation of RNA biosynthetic process
CFP59_RS47590	COG0804	urea catabolic process
CFP59_RS47600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CFP59_RS47605	COG0829	nickel cation binding
CFP59_RS47610	COG0492	ferredoxin-NADP+ reductase activity
CFP59_RS47640	COG1902	pentaerythritol trinitrate reductase activity
CFP59_RS47705	COG1063	alcohol dehydrogenase
CFP59_RS47710	COG0371	Dehydrogenase
CFP59_RS47715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFP59_RS47775	COG0163	prenyltransferase activity
CFP59_RS47790	COG2080	2 iron, 2 sulfur cluster binding
CFP59_RS47820	COG4948	Mandelate Racemase Muconate Lactonizing
CFP59_RS47830	COG0028	Belongs to the TPP enzyme family
CFP59_RS47835	COG1304	FMN binding
CFP59_RS47840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CFP59_RS47870	COG1309	transcriptional regulator
CFP59_RS47885	COG2801	Transposase and inactivated derivatives
CFP59_RS47885	COG3415	Transposase
CFP59_RS47920	COG0395	ABC-type sugar transport system, permease component
CFP59_RS47925	COG1175	transmembrane transport
CFP59_RS47935	COG1609	Transcriptional regulator
CFP59_RS47955	COG1175	transmembrane transport
CFP59_RS47960	COG0395	ABC-type sugar transport system, permease component
CFP59_RS47970	COG1609	Transcriptional regulator
CFP59_RS48025	COG3293	Transposase
CFP59_RS48080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CFP59_RS48155	COG2801	Transposase and inactivated derivatives
CFP59_RS48200	COG1309	transcriptional regulator
CFP59_RS48220	COG1733	regulation of RNA biosynthetic process
CFP59_RS48235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFP59_RS48265	COG3293	Transposase
CFP59_RS48375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFP59_RS48405	COG3226	Transcriptional regulator
CFP59_RS48425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFP59_RS48435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity