locus-tag	class	description
M444_RS00060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M444_RS00065	COG1518	maintenance of DNA repeat elements
M444_RS00080	COG1857	crispr-associated protein
M444_RS00180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M444_RS00185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M444_RS00200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M444_RS00265	COG4335	DNA alkylation repair
M444_RS00315	COG0659	secondary active sulfate transmembrane transporter activity
M444_RS00335	COG2824	Alkylphosphonate utilization operon protein PhnA
M444_RS00375	COG2318	DinB family
M444_RS00380	COG2239	Acts as a magnesium transporter
M444_RS00430	COG1051	belongs to the nudix hydrolase family
M444_RS00435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M444_RS00445	COG0438	transferase activity, transferring glycosyl groups
M444_RS00450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M444_RS00455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M444_RS00470	COG0717	Belongs to the dCTP deaminase family
M444_RS00525	COG3883	PFAM NLP P60 protein
M444_RS00525	COG0791	NLP P60 protein
M444_RS00625	COG2188	Transcriptional regulator
M444_RS00630	COG2801	Transposase and inactivated derivatives
M444_RS00640	COG2826	transposase and inactivated derivatives, IS30 family
M444_RS00650	COG0142	geranyltranstransferase activity
M444_RS00675	COG4106	trans-aconitate 2-methyltransferase activity
M444_RS00715	COG2801	Transposase and inactivated derivatives
M444_RS00730	COG0436	Aminotransferase
M444_RS00735	COG2423	ornithine cyclodeaminase activity
M444_RS00775	COG3328	transposase activity
M444_RS00795	COG2826	transposase and inactivated derivatives, IS30 family
M444_RS00835	COG1609	Transcriptional regulator
M444_RS00840	COG1879	ABC-type sugar transport system periplasmic component
M444_RS00845	COG1172	Belongs to the binding-protein-dependent transport system permease family
M444_RS00855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M444_RS00860	COG1869	D-ribose catabolic process
M444_RS00870	COG2801	Transposase and inactivated derivatives
M444_RS00890	COG1172	Belongs to the binding-protein-dependent transport system permease family
M444_RS00930	COG0009	L-threonylcarbamoyladenylate synthase
M444_RS00935	COG1278	Cold shock
M444_RS00980	COG2358	TRAP transporter, solute receptor (TAXI family
M444_RS00985	COG2205	protein histidine kinase activity
M444_RS00990	COG0745	RESPONSE REGULATOR receiver
M444_RS01015	COG2963	transposase activity
M444_RS01020	COG0789	Transcriptional regulator
M444_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
M444_RS01035	COG1937	Protein conserved in bacteria
M444_RS01040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M444_RS01045	COG0730	response to heat
M444_RS01050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M444_RS01055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M444_RS01055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS01070	COG3547	Transposase (IS116 IS110 IS902 family)
M444_RS01075	COG2826	transposase and inactivated derivatives, IS30 family
M444_RS01080	COG2801	Transposase and inactivated derivatives
M444_RS01255	COG1484	DNA-dependent DNA replication
M444_RS01300	COG2770	Histidine kinase
M444_RS01300	COG2208	phosphoserine phosphatase activity
M444_RS01340	COG0330	HflC and HflK could
M444_RS01355	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
M444_RS01360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M444_RS01380	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS01390	COG2801	Transposase and inactivated derivatives
M444_RS01395	COG2963	transposase activity
M444_RS01415	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M444_RS01420	COG0531	amino acid
M444_RS01440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M444_RS01445	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M444_RS01450	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M444_RS01590	COG0531	amino acid
M444_RS01670	COG1366	Belongs to the anti-sigma-factor antagonist family
M444_RS01685	COG0693	protein deglycase activity
M444_RS01685	COG0753	catalase activity
M444_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS01700	COG1063	alcohol dehydrogenase
M444_RS01740	COG1191	sigma factor activity
M444_RS01785	COG1309	transcriptional regulator
M444_RS01790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M444_RS01810	COG3118	belongs to the thioredoxin family
M444_RS01815	COG2318	DinB family
M444_RS01845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M444_RS01980	COG1278	Cold shock
M444_RS02005	COG0513	Belongs to the DEAD box helicase family
M444_RS02010	COG1278	Cold shock
M444_RS02060	COG0542	response to heat
M444_RS02070	COG0484	heat shock protein binding
M444_RS02075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M444_RS02080	COG0443	Heat shock 70 kDa protein
M444_RS02125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M444_RS02130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M444_RS02135	COG0022	dehydrogenase e1 component
M444_RS02135	COG0508	dehydrogenase complex catalyzes the overall conversion of
M444_RS02140	COG0508	dehydrogenase complex catalyzes the overall conversion of
M444_RS02145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M444_RS02170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M444_RS02185	COG0574	Belongs to the PEP-utilizing enzyme family
M444_RS02185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M444_RS02220	COG0516	GMP reductase activity
M444_RS02220	COG0517	IMP dehydrogenase activity
M444_RS02235	COG1131	(ABC) transporter
M444_RS02245	COG0517	IMP dehydrogenase activity
M444_RS02250	COG0517	IMP dehydrogenase activity
M444_RS02250	COG0516	GMP reductase activity
M444_RS02280	COG0577	efflux transmembrane transporter activity
M444_RS02280	COG1136	(ABC) transporter
M444_RS02285	COG0577	efflux transmembrane transporter activity
M444_RS02285	COG1136	(ABC) transporter
M444_RS02450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M444_RS02455	COG1088	dTDP-glucose 4,6-dehydratase activity
M444_RS02460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M444_RS02465	COG0745	RESPONSE REGULATOR receiver
M444_RS02485	COG3209	COG3209 Rhs family protein
M444_RS02490	COG0667	Aldo Keto reductase
M444_RS02510	COG1846	Transcriptional regulator
M444_RS02585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M444_RS02600	COG0402	S-adenosylhomocysteine deaminase activity
M444_RS02640	COG4221	oxidoreductase activity
M444_RS02660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M444_RS02665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M444_RS02670	COG2890	protein-(glutamine-N5) methyltransferase activity
M444_RS02680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M444_RS02690	COG0431	NADPH-dependent FMN reductase
M444_RS02710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M444_RS02735	COG0596	Alpha beta hydrolase
M444_RS02740	COG3226	Transcriptional regulator
M444_RS02780	COG0477	Major facilitator Superfamily
M444_RS02790	COG0667	Aldo Keto reductase
M444_RS02795	COG2124	cytochrome p450
M444_RS02875	COG0789	Transcriptional regulator
M444_RS02885	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS02890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M444_RS02905	COG0181	hydroxymethylbilane synthase activity
M444_RS02920	COG1302	Protein conserved in bacteria
M444_RS02970	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M444_RS02975	COG0076	glutamate decarboxylase activity
M444_RS02985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M444_RS03010	COG2207	Transcriptional regulator
M444_RS03010	COG3708	Transcriptional regulator
M444_RS03020	COG0367	asparagine synthase
M444_RS03040	COG0702	epimerase
M444_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS03105	COG2770	Histidine kinase
M444_RS03105	COG2208	phosphoserine phosphatase activity
M444_RS03110	COG0596	Alpha beta hydrolase
M444_RS03155	COG1937	Protein conserved in bacteria
M444_RS03160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M444_RS03175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS03175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M444_RS03225	COG1902	pentaerythritol trinitrate reductase activity
M444_RS03250	COG0477	Major facilitator Superfamily
M444_RS03280	COG0739	heme binding
M444_RS03330	COG1063	alcohol dehydrogenase
M444_RS03365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M444_RS03440	COG2267	carboxylic ester hydrolase activity
M444_RS03455	COG2508	Transcriptional regulator
M444_RS03460	COG1725	Transcriptional regulator
M444_RS03465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M444_RS03525	COG2045	Belongs to the ComB family
M444_RS03530	COG3386	PFAM SMP-30 Gluconolaconase
M444_RS03555	COG1278	Cold shock
M444_RS03575	COG1132	(ABC) transporter
M444_RS03580	COG0515	serine threonine protein kinase
M444_RS03595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M444_RS03630	COG2124	cytochrome p450
M444_RS03660	COG2226	methyltransferase
M444_RS03680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M444_RS03750	COG2318	DinB family
M444_RS03775	COG2376	Dihydroxyacetone kinase
M444_RS03780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M444_RS03785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M444_RS03795	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M444_RS03820	COG2814	Major facilitator Superfamily
M444_RS03845	COG1132	(ABC) transporter
M444_RS03860	COG4221	oxidoreductase activity
M444_RS03875	COG1113	amino acid transport
M444_RS03915	COG2814	Major facilitator Superfamily
M444_RS03975	COG0673	inositol 2-dehydrogenase activity
M444_RS03985	COG1476	TRANSCRIPTIONal
M444_RS04030	COG2135	peptidase activity
M444_RS04060	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
M444_RS04070	COG4941	Belongs to the sigma-70 factor family
M444_RS04140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M444_RS04155	COG0668	transmembrane transport
M444_RS04175	COG3903	Transcriptional regulator
M444_RS04175	COG3629	intracellular signal transduction
M444_RS04190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M444_RS04235	COG2208	phosphoserine phosphatase activity
M444_RS04235	COG2770	Histidine kinase
M444_RS04245	COG1794	racemase activity, acting on amino acids and derivatives
M444_RS04270	COG0009	L-threonylcarbamoyladenylate synthase
M444_RS04300	COG0298	carbon dioxide binding
M444_RS04305	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
M444_RS04310	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M444_RS04315	COG0375	protein maturation
M444_RS04355	COG1024	Enoyl-CoA hydratase
M444_RS04355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M444_RS04375	COG0328	RNA-DNA hybrid ribonuclease activity
M444_RS04385	COG0477	Major facilitator Superfamily
M444_RS04395	COG1376	ErfK ybiS ycfS ynhG family protein
M444_RS04400	COG0583	DNA-binding transcription factor activity
M444_RS04425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M444_RS04430	COG4566	intracellular signal transduction
M444_RS04445	COG3469	chitinase activity
M444_RS04495	COG2409	Drug exporters of the RND superfamily
M444_RS04520	COG0308	aminopeptidase N
M444_RS04540	COG3959	Transketolase, thiamine diphosphate binding domain
M444_RS04565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M444_RS04575	COG3425	synthase
M444_RS04580	COG4221	oxidoreductase activity
M444_RS04580	COG0300	oxidoreductase activity
M444_RS04580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M444_RS04580	COG3321	synthase
M444_RS04585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M444_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS04635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M444_RS04635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M444_RS04635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M444_RS04635	COG3321	synthase
M444_RS04640	COG0604	alcohol dehydrogenase
M444_RS04640	COG3321	synthase
M444_RS04645	COG1024	Enoyl-CoA hydratase
M444_RS04650	COG3425	synthase
M444_RS04665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M444_RS04680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M444_RS04700	COG1172	Belongs to the binding-protein-dependent transport system permease family
M444_RS04710	COG2197	response regulator
M444_RS04770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M444_RS04780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M444_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS04810	COG1131	(ABC) transporter
M444_RS04825	COG0604	alcohol dehydrogenase
M444_RS04825	COG3321	synthase
M444_RS04840	COG0604	alcohol dehydrogenase
M444_RS04840	COG3321	synthase
M444_RS04845	COG3321	synthase
M444_RS04845	COG0604	alcohol dehydrogenase
M444_RS04860	COG0604	alcohol dehydrogenase
M444_RS04860	COG3321	synthase
M444_RS04885	COG4585	Histidine kinase
M444_RS04890	COG2197	response regulator
M444_RS04910	COG0693	protein deglycase activity
M444_RS04915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS04945	COG0577	efflux transmembrane transporter activity
M444_RS04945	COG1136	(ABC) transporter
M444_RS04960	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS05000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M444_RS05010	COG0477	Major facilitator Superfamily
M444_RS05015	COG3387	PFAM Glycoside hydrolase 15-related
M444_RS05040	COG1271	oxidase subunit
M444_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS05050	COG3265	gluconokinase activity
M444_RS05070	COG0546	phosphoglycolate phosphatase activity
M444_RS05080	COG2261	transglycosylase associated protein
M444_RS05090	COG3903	Transcriptional regulator
M444_RS05090	COG3629	intracellular signal transduction
M444_RS05185	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M444_RS05220	COG2124	cytochrome p450
M444_RS05305	COG0346	lactoylglutathione lyase activity
M444_RS05360	COG0714	Associated with various cellular activities
M444_RS05405	COG1404	Belongs to the peptidase S8 family
M444_RS05460	COG2205	protein histidine kinase activity
M444_RS05470	COG0189	ligase activity
M444_RS05500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M444_RS05505	COG3842	ATPase activity
M444_RS05525	COG2188	Transcriptional regulator
M444_RS05540	COG0515	serine threonine protein kinase
M444_RS05540	COG2815	serine threonine protein kinase
M444_RS05550	COG2319	Wd-40 repeat
M444_RS05550	COG4249	Peptidase C14 caspase catalytic subunit p20
M444_RS05555	COG1136	(ABC) transporter
M444_RS05555	COG4591	ABC-type transport system involved in lipoprotein release permease component
M444_RS05570	COG1136	(ABC) transporter
M444_RS05570	COG0577	efflux transmembrane transporter activity
M444_RS05580	COG4941	Belongs to the sigma-70 factor family
M444_RS05600	COG2837	iron assimilation
M444_RS05615	COG2124	cytochrome p450
M444_RS05630	COG3759	membrane
M444_RS05640	COG1278	Cold shock
M444_RS05645	COG0513	Belongs to the DEAD box helicase family
M444_RS05695	COG0604	alcohol dehydrogenase
M444_RS05700	COG2723	6-phospho-beta-galactosidase activity
M444_RS05705	COG0395	ABC-type sugar transport system, permease component
M444_RS05710	COG1175	transmembrane transport
M444_RS05720	COG1846	Transcriptional regulator
M444_RS05720	COG1940	carbohydrate kinase activity
M444_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS05765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M444_RS05785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M444_RS05820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M444_RS05885	COG0531	amino acid
M444_RS05910	COG1053	succinate dehydrogenase
M444_RS05940	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M444_RS05940	COG1672	PFAM Archaeal ATPase
M444_RS05975	COG1024	Enoyl-CoA hydratase
M444_RS05985	COG2267	carboxylic ester hydrolase activity
M444_RS06000	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS06005	COG2366	antibiotic biosynthetic process
M444_RS06010	COG0387	Pfam Sodium calcium exchanger
M444_RS06020	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS06025	COG2070	2-Nitropropane dioxygenase
M444_RS06030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M444_RS06055	COG2815	serine threonine protein kinase
M444_RS06055	COG0515	serine threonine protein kinase
M444_RS06065	COG1960	acyl-CoA dehydrogenase activity
M444_RS06080	COG1349	DNA-binding transcription factor activity
M444_RS06090	COG0156	8-amino-7-oxononanoate synthase activity
M444_RS06095	COG1063	alcohol dehydrogenase
M444_RS06115	COG0477	Major facilitator Superfamily
M444_RS06145	COG3387	PFAM Glycoside hydrolase 15-related
M444_RS06150	COG2259	Doxx family
M444_RS06175	COG1461	Dihydroxyacetone kinase
M444_RS06195	COG0725	ABC transporter, periplasmic molybdate-binding protein
M444_RS06235	COG0702	epimerase
M444_RS06255	COG1716	ATPase activity
M444_RS06255	COG0842	Transport permease protein
M444_RS06255	COG1131	(ABC) transporter
M444_RS06290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M444_RS06320	COG1397	ADP-ribosylglycohydrolase
M444_RS06325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M444_RS06330	COG0463	Glycosyl transferase, family 2
M444_RS06375	COG1940	carbohydrate kinase activity
M444_RS06410	COG0445	tRNA wobble uridine modification
M444_RS06445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M444_RS06500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS06505	COG0584	glycerophosphoryl diester phosphodiesterase
M444_RS06525	COG0671	phosphoesterase, PA-phosphatase related
M444_RS06535	COG1309	transcriptional regulator
M444_RS06550	COG0493	'glutamate synthase
M444_RS06555	COG0640	Transcriptional regulator
M444_RS06560	COG1902	pentaerythritol trinitrate reductase activity
M444_RS06575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M444_RS06590	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M444_RS06610	COG1309	transcriptional regulator
M444_RS06635	COG4221	oxidoreductase activity
M444_RS06645	COG0446	pyridine nucleotide-disulphide oxidoreductase
M444_RS06645	COG1902	pentaerythritol trinitrate reductase activity
M444_RS06650	COG2267	carboxylic ester hydrolase activity
M444_RS06660	COG0395	ABC-type sugar transport system, permease component
M444_RS06665	COG1175	transmembrane transport
M444_RS06690	COG3345	alpha-galactosidase
M444_RS06705	COG0142	geranyltranstransferase activity
M444_RS06735	COG0583	DNA-binding transcription factor activity
M444_RS06740	COG3321	synthase
M444_RS06740	COG0604	alcohol dehydrogenase
M444_RS06755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M444_RS06765	COG4106	trans-aconitate 2-methyltransferase activity
M444_RS06775	COG3511	phospholipase C
M444_RS06785	COG1024	Enoyl-CoA hydratase
M444_RS06790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M444_RS06800	COG2223	nitrite transmembrane transporter activity
M444_RS06805	COG1335	isochorismatase
M444_RS06825	COG2226	methyltransferase
M444_RS06830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M444_RS06855	COG2205	protein histidine kinase activity
M444_RS06900	COG0346	lactoylglutathione lyase activity
M444_RS06905	COG1556	Lactate utilization protein
M444_RS06910	COG1139	Iron-sulfur cluster binding protein
M444_RS06915	COG0247	lactate metabolic process
M444_RS06925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M444_RS06945	COG2838	Isocitrate dehydrogenase
M444_RS06950	COG3152	Membrane
M444_RS06965	COG0598	Magnesium transport protein CorA
M444_RS06980	COG0583	DNA-binding transcription factor activity
M444_RS06985	COG0697	spore germination
M444_RS07000	COG0697	spore germination
M444_RS07015	COG1695	Transcriptional regulator
M444_RS07030	COG0384	phenazine biosynthesis protein PhzF
M444_RS07055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M444_RS07055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M444_RS07065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M444_RS07105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M444_RS07135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M444_RS07145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M444_RS07160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M444_RS07190	COG2018	Roadblock/LC7 domain
M444_RS07220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M444_RS07225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M444_RS07230	COG1984	allophanate hydrolase subunit 2
M444_RS07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M444_RS07270	COG2270	Major facilitator Superfamily
M444_RS07285	COG0463	Glycosyl transferase, family 2
M444_RS07315	COG1960	acyl-CoA dehydrogenase activity
M444_RS07320	COG1309	transcriptional regulator
M444_RS07340	COG0572	uridine kinase
M444_RS07365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M444_RS07370	COG0140	phosphoribosyl-ATP diphosphatase activity
M444_RS07375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M444_RS07380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M444_RS07380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M444_RS07385	COG3201	nicotinamide mononucleotide transporter
M444_RS07410	COG1940	carbohydrate kinase activity
M444_RS07410	COG1846	Transcriptional regulator
M444_RS07415	COG0738	Major facilitator superfamily
M444_RS07420	COG2233	PERMEase
M444_RS07435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M444_RS07450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS07460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS07475	COG0531	amino acid
M444_RS07480	COG2755	lipolytic protein G-D-S-L family
M444_RS07490	COG3279	Response regulator of the LytR AlgR family
M444_RS07505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M444_RS07510	COG3275	phosphorelay sensor kinase activity
M444_RS07530	COG3548	integral membrane protein
M444_RS07570	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS07580	COG0489	protein tyrosine kinase activity
M444_RS07585	COG2208	phosphoserine phosphatase activity
M444_RS07585	COG2770	Histidine kinase
M444_RS07605	COG1366	Belongs to the anti-sigma-factor antagonist family
M444_RS07620	COG0693	protein deglycase activity
M444_RS07625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M444_RS07645	COG0028	Belongs to the TPP enzyme family
M444_RS07660	COG0492	ferredoxin-NADP+ reductase activity
M444_RS07675	COG2346	COG2346, Truncated hemoglobins
M444_RS07695	COG2390	Transcriptional regulator
M444_RS07700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M444_RS07710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M444_RS07725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M444_RS07740	COG0194	GDP metabolic process
M444_RS07750	COG0284	orotidine-5'-phosphate decarboxylase activity
M444_RS07755	COG0167	dihydroorotate dehydrogenase activity
M444_RS07760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M444_RS07765	COG0505	Belongs to the CarA family
M444_RS07775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M444_RS07780	COG0540	Belongs to the ATCase OTCase family
M444_RS07785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M444_RS07795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M444_RS07800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M444_RS07805	COG0006	proline dipeptidase activity
M444_RS07815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M444_RS07820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M444_RS07825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M444_RS07830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M444_RS07840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M444_RS07850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M444_RS07855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M444_RS07875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M444_RS07900	COG0124	histidyl-tRNA synthetase
M444_RS07910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M444_RS07915	COG1196	nuclear chromosome segregation
M444_RS07920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M444_RS07925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M444_RS07930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M444_RS07935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M444_RS07945	COG2255	four-way junction helicase activity
M444_RS07950	COG0632	four-way junction helicase activity
M444_RS07955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M444_RS07960	COG0217	transcriptional regulatory protein
M444_RS07965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M444_RS07970	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M444_RS07980	COG0438	transferase activity, transferring glycosyl groups
M444_RS07985	COG1560	Kdo2-lipid A biosynthetic process
M444_RS07990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M444_RS08010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M444_RS08015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M444_RS08035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M444_RS08090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M444_RS08150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M444_RS08150	COG1648	precorrin-2 dehydrogenase activity
M444_RS08155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M444_RS08170	COG1464	Belongs to the NlpA lipoprotein family
M444_RS08175	COG2011	ABC-type metal ion transport system permease component
M444_RS08180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M444_RS08210	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS08210	COG0204	Acyl-transferase
M444_RS08220	COG0477	Major facilitator Superfamily
M444_RS08235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M444_RS08270	COG0165	Argininosuccinate lyase
M444_RS08275	COG0137	argininosuccinate synthase activity
M444_RS08295	COG1438	arginine binding
M444_RS08300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M444_RS08305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M444_RS08310	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M444_RS08315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M444_RS08335	COG0697	spore germination
M444_RS08345	COG1649	PFAM Uncharacterised BCR, COG1649
M444_RS08365	COG0072	phenylalanine-tRNA ligase activity
M444_RS08365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M444_RS08370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M444_RS08375	COG5002	protein histidine kinase activity
M444_RS08380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M444_RS08385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M444_RS08390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M444_RS08395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M444_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS08435	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS08440	COG0174	glutamine synthetase
M444_RS08450	COG1113	amino acid transport
M444_RS08455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M444_RS08470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M444_RS08480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M444_RS08495	COG0564	pseudouridine synthase activity
M444_RS08510	COG0805	protein transport
M444_RS08515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M444_RS08550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M444_RS08560	COG1609	Transcriptional regulator
M444_RS08565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M444_RS08570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M444_RS08585	COG4122	O-methyltransferase activity
M444_RS08590	COG1222	aaa ATPase
M444_RS08610	COG1994	Peptidase M50
M444_RS08610	COG0517	IMP dehydrogenase activity
M444_RS08620	COG2197	response regulator
M444_RS08640	COG0646	methionine synthase
M444_RS08640	COG1410	methionine synthase
M444_RS08645	COG1414	Transcriptional regulator
M444_RS08650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M444_RS08655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M444_RS08660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M444_RS08670	COG0215	cysteine-tRNA ligase activity
M444_RS08690	COG0598	Magnesium transport protein CorA
M444_RS08700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS08705	COG0667	Aldo Keto reductase
M444_RS08735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M444_RS08745	COG1113	amino acid transport
M444_RS08770	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M444_RS08775	COG2149	membrane
M444_RS08790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS08815	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS08825	COG3876	Protein conserved in bacteria
M444_RS08865	COG1960	acyl-CoA dehydrogenase activity
M444_RS08885	COG2851	Citrate transporter
M444_RS08890	COG3383	formate dehydrogenase (NAD+) activity
M444_RS08895	COG1309	transcriptional regulator
M444_RS08920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M444_RS08925	COG2188	Transcriptional regulator
M444_RS08950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M444_RS08960	COG0515	serine threonine protein kinase
M444_RS08960	COG2815	serine threonine protein kinase
M444_RS08965	COG2755	lipolytic protein G-D-S-L family
M444_RS08975	COG4044	May play a role in the intracellular transport of hydrophobic ligands
M444_RS08980	COG1725	Transcriptional regulator
M444_RS09010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M444_RS09015	COG0587	DNA-directed DNA polymerase activity
M444_RS09050	COG0641	radical SAM
M444_RS09095	COG1799	cell septum assembly
M444_RS09100	COG1960	acyl-CoA dehydrogenase activity
M444_RS09105	COG0477	Major facilitator Superfamily
M444_RS09115	COG0671	phosphoesterase, PA-phosphatase related
M444_RS09120	COG3583	domain protein
M444_RS09135	COG1160	GTP binding
M444_RS09145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M444_RS09180	COG1051	belongs to the nudix hydrolase family
M444_RS09195	COG1187	pseudouridine synthase activity
M444_RS09200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M444_RS09205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M444_RS09220	COG0686	Belongs to the AlaDH PNT family
M444_RS09230	COG0494	nUDIX hydrolase
M444_RS09235	COG0504	CTP synthase activity
M444_RS09240	COG3387	PFAM Glycoside hydrolase 15-related
M444_RS09270	COG0297	glycogen (starch) synthase activity
M444_RS09275	COG0497	DNA recombination
M444_RS09280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M444_RS09300	COG1120	ATPase activity
M444_RS09305	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M444_RS09310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M444_RS09315	COG0647	UMP catabolic process
M444_RS09350	COG2094	Belongs to the DNA glycosylase MPG family
M444_RS09360	COG1881	PFAM PEBP family protein
M444_RS09385	COG1119	ATPase activity
M444_RS09400	COG2197	response regulator
M444_RS09405	COG4585	Histidine kinase
M444_RS09425	COG0842	Transport permease protein
M444_RS09425	COG1131	(ABC) transporter
M444_RS09425	COG1716	ATPase activity
M444_RS09430	COG0560	Phosphoserine phosphatase
M444_RS09430	COG3830	Belongs to the UPF0237 family
M444_RS09450	COG2186	Transcriptional regulator
M444_RS09460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M444_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS09480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M444_RS09500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M444_RS09505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M444_RS09515	COG1404	Belongs to the peptidase S8 family
M444_RS09520	COG1063	alcohol dehydrogenase
M444_RS09560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M444_RS09600	COG1302	Protein conserved in bacteria
M444_RS09610	COG1024	Enoyl-CoA hydratase
M444_RS09620	COG0488	(ABC) transporter
M444_RS09655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M444_RS09660	COG1492	cobalamin metabolic process
M444_RS09675	COG1797	cobyrinic acid a,c-diamide synthase activity
M444_RS09705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M444_RS09710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M444_RS09730	COG2197	response regulator
M444_RS09735	COG4585	Histidine kinase
M444_RS09785	COG2171	N-acyltransferase activity
M444_RS09800	COG3226	Transcriptional regulator
M444_RS09805	COG2076	Multidrug Resistance protein
M444_RS09815	COG2151	metal-sulfur cluster biosynthetic enzyme
M444_RS09820	COG0822	iron-sulfur transferase activity
M444_RS09825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M444_RS09830	COG0396	ATPase activity
M444_RS09840	COG0719	Fe-S assembly protein
M444_RS09870	COG1612	heme a metabolic process
M444_RS09885	COG0109	protoheme IX farnesyltransferase activity
M444_RS09895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M444_RS09910	COG0363	glucosamine-6-phosphate deaminase activity
M444_RS09915	COG0166	Belongs to the GPI family
M444_RS09925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M444_RS09930	COG0149	triose-phosphate isomerase activity
M444_RS09935	COG0126	phosphoglycerate kinase activity
M444_RS09940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M444_RS09950	COG1481	regulation of sporulation
M444_RS09960	COG1660	Displays ATPase and GTPase activities
M444_RS09965	COG0322	excinuclease ABC activity
M444_RS09980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M444_RS09990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS09995	COG0477	Major facilitator Superfamily
M444_RS10015	COG0556	nucleotide-excision repair
M444_RS10020	COG0584	glycerophosphoryl diester phosphodiesterase
M444_RS10025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M444_RS10040	COG2313	pseudouridylate synthase activity
M444_RS10080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M444_RS10095	COG0237	dephospho-CoA kinase activity
M444_RS10105	COG0539	negative regulation of cytoplasmic translation
M444_RS10110	COG2226	methyltransferase
M444_RS10115	COG1643	Atp-dependent helicase
M444_RS10150	COG2050	protein possibly involved in aromatic compounds catabolism
M444_RS10165	COG0559	Belongs to the binding-protein-dependent transport system permease family
M444_RS10210	COG0737	Belongs to the 5'-nucleotidase family
M444_RS10235	COG1605	Chorismate mutase
M444_RS10235	COG0287	Prephenate dehydrogenase
M444_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS10260	COG1024	Enoyl-CoA hydratase
M444_RS10280	COG2365	Tyrosine phosphatase family
M444_RS10290	COG1278	Cold shock
M444_RS10295	COG0183	Belongs to the thiolase family
M444_RS10300	COG1309	transcriptional regulator
M444_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS10310	COG1960	acyl-CoA dehydrogenase activity
M444_RS10315	COG1960	acyl-CoA dehydrogenase activity
M444_RS10405	COG0070	glutamate synthase
M444_RS10405	COG0067	glutamate synthase
M444_RS10405	COG0069	glutamate synthase activity
M444_RS10415	COG1397	ADP-ribosylglycohydrolase
M444_RS10435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M444_RS10440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M444_RS10450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M444_RS10460	COG0159	tryptophan synthase activity
M444_RS10465	COG0133	tryptophan synthase activity
M444_RS10475	COG0134	indole-3-glycerol-phosphate synthase activity
M444_RS10500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M444_RS10510	COG0107	imidazoleglycerol-phosphate synthase activity
M444_RS10515	COG0251	oxidation-reduction process
M444_RS10520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M444_RS10525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M444_RS10535	COG0131	Imidazoleglycerol-phosphate dehydratase
M444_RS10540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M444_RS10545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M444_RS10560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M444_RS10580	COG1432	Conserved Protein
M444_RS10585	COG0587	DNA-directed DNA polymerase activity
M444_RS10640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M444_RS10650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M444_RS10655	COG3599	regulation of cell shape
M444_RS10665	COG1799	cell septum assembly
M444_RS10680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M444_RS10685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M444_RS10690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M444_RS10700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M444_RS10705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M444_RS10715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M444_RS10720	COG0768	penicillin binding
M444_RS10730	COG0275	rRNA processing
M444_RS10740	COG0714	Associated with various cellular activities
M444_RS10755	COG1309	transcriptional regulator
M444_RS10765	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M444_RS10775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M444_RS10790	COG1233	COG1233 Phytoene dehydrogenase and related
M444_RS10805	COG0352	thiamine-phosphate diphosphorylase activity
M444_RS10815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M444_RS10820	COG2022	thiamine diphosphate biosynthetic process
M444_RS10820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M444_RS10830	COG2022	thiamine diphosphate biosynthetic process
M444_RS10835	COG2815	serine threonine protein kinase
M444_RS10835	COG0515	serine threonine protein kinase
M444_RS10840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M444_RS10850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M444_RS10855	COG2193	ferroxidase activity
M444_RS10865	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M444_RS10880	COG0205	6-phosphofructokinase activity
M444_RS10885	COG2197	response regulator
M444_RS10890	COG4585	Histidine kinase
M444_RS10915	COG1940	carbohydrate kinase activity
M444_RS10925	COG0003	Pfam Anion-transporting ATPase
M444_RS10940	COG1022	Amp-dependent synthetase and ligase
M444_RS10950	COG0438	transferase activity, transferring glycosyl groups
M444_RS10995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M444_RS11000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M444_RS11005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M444_RS11010	COG0723	plastoquinol--plastocyanin reductase activity
M444_RS11015	COG2010	Cytochrome c
M444_RS11020	COG1845	cytochrome c oxidase, subunit III
M444_RS11030	COG1376	ErfK ybiS ycfS ynhG family protein
M444_RS11040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M444_RS11045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M444_RS11055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M444_RS11075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M444_RS11085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M444_RS11090	COG2197	response regulator
M444_RS11095	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M444_RS11120	COG2226	methyltransferase
M444_RS11135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M444_RS11140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M444_RS11140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M444_RS11150	COG4585	Histidine kinase
M444_RS11170	COG0438	transferase activity, transferring glycosyl groups
M444_RS11180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M444_RS11185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M444_RS11190	COG0508	dehydrogenase complex catalyzes the overall conversion of
M444_RS11215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M444_RS11255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M444_RS11260	COG0321	lipoyl(octanoyl) transferase activity
M444_RS11320	COG0745	RESPONSE REGULATOR receiver
M444_RS11340	COG2365	Tyrosine phosphatase family
M444_RS11360	COG1309	transcriptional regulator
M444_RS11390	COG0366	Alpha amylase catalytic
M444_RS11395	COG3833	ABC-type maltose transport systems, permease component
M444_RS11400	COG1175	transmembrane transport
M444_RS11410	COG0366	Alpha amylase catalytic
M444_RS11415	COG1609	Transcriptional regulator
M444_RS11435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M444_RS11455	COG0174	glutamine synthetase
M444_RS11480	COG2267	carboxylic ester hydrolase activity
M444_RS11495	COG2132	Multicopper oxidase
M444_RS11515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M444_RS11535	COG1994	Peptidase M50
M444_RS11595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M444_RS11600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M444_RS11605	COG1120	ATPase activity
M444_RS11615	COG2837	iron assimilation
M444_RS11620	COG0672	)-iron permease
M444_RS11630	COG0384	phenazine biosynthesis protein PhzF
M444_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS11640	COG2814	Major facilitator Superfamily
M444_RS11650	COG1834	amidinotransferase
M444_RS11665	COG3022	response to hydroperoxide
M444_RS11670	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M444_RS11685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M444_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS11705	COG2030	dehydratase
M444_RS11710	COG2197	response regulator
M444_RS11715	COG0183	Belongs to the thiolase family
M444_RS11720	COG1960	acyl-CoA dehydrogenase activity
M444_RS11735	COG0860	N-Acetylmuramoyl-L-alanine amidase
M444_RS11745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS11770	COG0438	transferase activity, transferring glycosyl groups
M444_RS11775	COG1309	transcriptional regulator
M444_RS11810	COG3845	ABC transporter
M444_RS11815	COG3845	ABC transporter
M444_RS11830	COG0183	Belongs to the thiolase family
M444_RS11835	COG2124	cytochrome p450
M444_RS11870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M444_RS11875	COG2318	DinB family
M444_RS11950	COG1358	cellular component organization or biogenesis
M444_RS11995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M444_RS12000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M444_RS12010	COG0477	Major facilitator Superfamily
M444_RS12015	COG1309	transcriptional regulator
M444_RS12030	COG0667	Aldo Keto reductase
M444_RS12035	COG0789	Transcriptional regulator
M444_RS12060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M444_RS12065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M444_RS12070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M444_RS12100	COG1764	response to oxidative stress
M444_RS12105	COG2130	NADP-dependent
M444_RS12125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M444_RS12130	COG1077	Cell shape determining protein MreB Mrl
M444_RS12150	COG0825	malonyl-CoA metabolic process
M444_RS12150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M444_RS12160	COG0477	Major facilitator Superfamily
M444_RS12165	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M444_RS12180	COG1131	(ABC) transporter
M444_RS12225	COG1070	Carbohydrate kinase
M444_RS12245	COG2949	membrane
M444_RS12255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M444_RS12265	COG0358	DNA primase activity
M444_RS12290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M444_RS12290	COG1017	nitric oxide dioxygenase activity
M444_RS12295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M444_RS12295	COG2146	nitrite reductase [NAD(P)H] activity
M444_RS12315	COG0574	Belongs to the PEP-utilizing enzyme family
M444_RS12315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M444_RS12340	COG0667	Aldo Keto reductase
M444_RS12345	COG1309	transcriptional regulator
M444_RS12355	COG0423	glycine-tRNA ligase activity
M444_RS12365	COG1121	(ABC) transporter
M444_RS12370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M444_RS12380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M444_RS12385	COG1381	Involved in DNA repair and RecF pathway recombination
M444_RS12400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M444_RS12425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M444_RS12455	COG2315	Protein conserved in bacteria
M444_RS12465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M444_RS12475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M444_RS12480	COG1234	tRNA 3'-trailer cleavage
M444_RS12485	COG0537	adenosine 5'-monophosphoramidase activity
M444_RS12495	COG2070	2-Nitropropane dioxygenase
M444_RS12500	COG0484	heat shock protein binding
M444_RS12505	COG1420	regulation of RNA biosynthetic process
M444_RS12530	COG0481	GTPase activity
M444_RS12535	COG0268	Binds directly to 16S ribosomal RNA
M444_RS12550	COG2353	YceI-like domain
M444_RS12580	COG1596	polysaccharide export
M444_RS12580	COG1555	photosystem II stabilization
M444_RS12585	COG1307	EDD domain protein, DegV family
M444_RS12595	COG0495	leucyl-tRNA aminoacylation
M444_RS12615	COG0588	phosphoglycerate mutase activity
M444_RS12620	COG0799	negative regulation of ribosome biogenesis
M444_RS12630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M444_RS12640	COG0501	Belongs to the peptidase M48B family
M444_RS12655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M444_RS12665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M444_RS12675	COG0463	Glycosyl transferase, family 2
M444_RS12680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M444_RS12680	COG0463	Glycosyl transferase, family 2
M444_RS12685	COG0438	transferase activity, transferring glycosyl groups
M444_RS12700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M444_RS12705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M444_RS12710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M444_RS12735	COG1530	ribonuclease E activity
M444_RS12755	COG0772	Belongs to the SEDS family
M444_RS12760	COG0768	penicillin binding
M444_RS12775	COG1077	Cell shape determining protein MreB Mrl
M444_RS12780	COG0105	UTP biosynthetic process
M444_RS12790	COG0285	dihydrofolate synthase activity
M444_RS12795	COG1077	Cell shape determining protein MreB Mrl
M444_RS12800	COG4585	Histidine kinase
M444_RS12805	COG0525	valine-tRNA ligase activity
M444_RS12815	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M444_RS12820	COG0740	serine-type endopeptidase activity
M444_RS12825	COG0740	serine-type endopeptidase activity
M444_RS12830	COG0544	peptidyl-prolyl cis-trans isomerase activity
M444_RS12865	COG1660	Displays ATPase and GTPase activities
M444_RS12875	COG4552	Acetyltransferase involved in intracellular survival and related
M444_RS12885	COG0698	ribose 5-phosphate isomerase
M444_RS12890	COG1113	amino acid transport
M444_RS12895	COG1268	BioY protein
M444_RS12900	COG1113	amino acid transport
M444_RS12905	COG1113	amino acid transport
M444_RS12910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M444_RS12915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M444_RS12965	COG0583	DNA-binding transcription factor activity
M444_RS12975	COG0697	spore germination
M444_RS12985	COG1846	Transcriptional regulator
M444_RS13015	COG0668	transmembrane transport
M444_RS13025	COG1653	transport
M444_RS13030	COG1175	transmembrane transport
M444_RS13035	COG0395	ABC-type sugar transport system, permease component
M444_RS13040	COG1486	melibiose metabolic process
M444_RS13055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M444_RS13065	COG0515	serine threonine protein kinase
M444_RS13085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M444_RS13090	COG2346	COG2346, Truncated hemoglobins
M444_RS13120	COG0629	single-stranded DNA binding
M444_RS13185	COG3962	Belongs to the TPP enzyme family
M444_RS13190	COG3718	enzyme involved in inositol metabolism
M444_RS13205	COG0673	inositol 2-dehydrogenase activity
M444_RS13215	COG2409	Drug exporters of the RND superfamily
M444_RS13240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M444_RS13255	COG0697	spore germination
M444_RS13265	COG1472	Belongs to the glycosyl hydrolase 3 family
M444_RS13305	COG1946	Acyl-CoA thioesterase
M444_RS13330	COG1309	transcriptional regulator
M444_RS13335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M444_RS13350	COG1960	acyl-CoA dehydrogenase activity
M444_RS13360	COG2375	cellular response to nickel ion
M444_RS13365	COG0076	glutamate decarboxylase activity
M444_RS13370	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M444_RS13400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M444_RS13410	COG0589	response to stress
M444_RS13420	COG4977	sequence-specific DNA binding
M444_RS13425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M444_RS13450	COG0395	ABC-type sugar transport system, permease component
M444_RS13470	COG0745	RESPONSE REGULATOR receiver
M444_RS13495	COG0406	alpha-ribazole phosphatase activity
M444_RS13550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS13570	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS13575	COG3397	chitin binding
M444_RS13640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M444_RS13645	COG2188	Transcriptional regulator
M444_RS13660	COG0673	inositol 2-dehydrogenase activity
M444_RS13670	COG0706	membrane insertase activity
M444_RS13680	COG3764	Sortase (surface protein transpeptidase)
M444_RS13715	COG2733	membrane
M444_RS13740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M444_RS13770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M444_RS13780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M444_RS13785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M444_RS13790	COG1263	PTS System
M444_RS13795	COG1263	PTS System
M444_RS13800	COG1234	tRNA 3'-trailer cleavage
M444_RS13810	COG3189	MarR family transcriptional regulator
M444_RS13830	COG1113	amino acid transport
M444_RS13840	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M444_RS13850	COG1335	isochorismatase
M444_RS13885	COG0277	FAD linked oxidase domain protein
M444_RS13895	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M444_RS13950	COG1404	Belongs to the peptidase S8 family
M444_RS13980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M444_RS13990	COG1678	Uncharacterized ACR, COG1678
M444_RS13995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M444_RS14000	COG0776	regulation of translation
M444_RS14010	COG3973	AAA domain
M444_RS14035	COG0583	DNA-binding transcription factor activity
M444_RS14055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M444_RS14060	COG0793	Belongs to the peptidase S41A family
M444_RS14070	COG2884	Cell division ATP-binding protein ftsE
M444_RS14080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M444_RS14090	COG0515	serine threonine protein kinase
M444_RS14095	COG0515	serine threonine protein kinase
M444_RS14105	COG1653	transport
M444_RS14110	COG1175	transmembrane transport
M444_RS14115	COG0395	ABC-type sugar transport system, permease component
M444_RS14135	COG1134	teichoic acid transport
M444_RS14135	COG1388	LysM domain
M444_RS14140	COG2902	Dehydrogenase
M444_RS14145	COG0546	phosphoglycolate phosphatase activity
M444_RS14160	COG0653	protein targeting
M444_RS14175	COG2197	response regulator
M444_RS14180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M444_RS14190	COG0823	Involved in the tonB-independent uptake of proteins
M444_RS14195	COG5002	protein histidine kinase activity
M444_RS14195	COG5000	phosphorelay sensor kinase activity
M444_RS14200	COG0745	RESPONSE REGULATOR receiver
M444_RS14220	COG0714	Associated with various cellular activities
M444_RS14260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M444_RS14270	COG1482	cell wall glycoprotein biosynthetic process
M444_RS14280	COG2835	tetraacyldisaccharide 4'-kinase activity
M444_RS14285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M444_RS14320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M444_RS14325	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
M444_RS14325	COG0778	Nitroreductase
M444_RS14345	COG1316	TRANSCRIPTIONal
M444_RS14370	COG1607	acyl-coa hydrolase
M444_RS14375	COG1316	TRANSCRIPTIONal
M444_RS14380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M444_RS14390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M444_RS14415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M444_RS14430	COG2205	protein histidine kinase activity
M444_RS14435	COG0745	RESPONSE REGULATOR receiver
M444_RS14440	COG3104	oligopeptide transport
M444_RS14465	COG1228	amidohydrolase
M444_RS14475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M444_RS14480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M444_RS14505	COG2755	lipolytic protein G-D-S-L family
M444_RS14510	COG0183	Belongs to the thiolase family
M444_RS14540	COG1136	(ABC) transporter
M444_RS14545	COG0577	efflux transmembrane transporter activity
M444_RS14550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M444_RS14555	COG1252	NADH dehydrogenase
M444_RS14575	COG0148	phosphopyruvate hydratase activity
M444_RS14590	COG2124	cytochrome p450
M444_RS14595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M444_RS14595	COG1017	nitric oxide dioxygenase activity
M444_RS14645	COG0577	efflux transmembrane transporter activity
M444_RS14650	COG1136	(ABC) transporter
M444_RS14655	COG2814	Major facilitator Superfamily
M444_RS14670	COG0596	Alpha beta hydrolase
M444_RS14700	COG4585	Histidine kinase
M444_RS14710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M444_RS14715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M444_RS14720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M444_RS14725	COG0193	aminoacyl-tRNA hydrolase activity
M444_RS14730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M444_RS14740	COG1309	transcriptional regulator
M444_RS14750	COG4106	trans-aconitate 2-methyltransferase activity
M444_RS14755	COG1846	Transcriptional regulator
M444_RS14760	COG2197	response regulator
M444_RS14785	COG0488	(ABC) transporter
M444_RS14795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M444_RS14800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M444_RS14805	COG3583	domain protein
M444_RS14805	COG3584	3D domain protein
M444_RS14810	COG0084	hydrolase, TatD family'
M444_RS14835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M444_RS14840	COG1122	ATPase activity
M444_RS14850	COG0310	cobalt ion transport
M444_RS14860	COG2409	Drug exporters of the RND superfamily
M444_RS14870	COG0793	Belongs to the peptidase S41A family
M444_RS14870	COG4946	Tricorn protease homolog
M444_RS14880	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS14885	COG2267	carboxylic ester hydrolase activity
M444_RS14890	COG2072	flavoprotein involved in K transport
M444_RS14920	COG2423	ornithine cyclodeaminase activity
M444_RS14925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M444_RS14930	COG4569	acetaldehyde dehydrogenase (acetylating) activity
M444_RS14940	COG0156	8-amino-7-oxononanoate synthase activity
M444_RS14955	COG0006	proline dipeptidase activity
M444_RS14975	COG0521	Mo-molybdopterin cofactor biosynthetic process
M444_RS14975	COG0315	cyclic pyranopterin monophosphate synthase activity
M444_RS14980	COG0315	cyclic pyranopterin monophosphate synthase activity
M444_RS14990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M444_RS14995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M444_RS15005	COG3263	regulation of cellular component size
M444_RS15020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M444_RS15030	COG1970	mechanosensitive ion channel activity
M444_RS15095	COG0438	transferase activity, transferring glycosyl groups
M444_RS15105	COG0728	peptidoglycan biosynthetic process
M444_RS15115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M444_RS15120	COG0438	transferase activity, transferring glycosyl groups
M444_RS15175	COG0477	Major facilitator Superfamily
M444_RS15195	COG3384	dioxygenase
M444_RS15245	COG3629	intracellular signal transduction
M444_RS15245	COG3903	Transcriptional regulator
M444_RS15285	COG3629	intracellular signal transduction
M444_RS15285	COG3903	Transcriptional regulator
M444_RS15305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M444_RS15335	COG0515	serine threonine protein kinase
M444_RS15360	COG1686	Belongs to the peptidase S11 family
M444_RS15395	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M444_RS15400	COG2365	Tyrosine phosphatase family
M444_RS15455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M444_RS15560	COG4974	Belongs to the 'phage' integrase family
M444_RS15575	COG2816	NAD+ diphosphatase activity
M444_RS15660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M444_RS15660	COG0515	serine threonine protein kinase
M444_RS15680	COG1960	acyl-CoA dehydrogenase activity
M444_RS15695	COG0259	pyridoxamine-phosphate oxidase activity
M444_RS15710	COG2072	flavoprotein involved in K transport
M444_RS15720	COG1024	Enoyl-CoA hydratase
M444_RS15735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M444_RS15745	COG1960	acyl-CoA dehydrogenase activity
M444_RS15750	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS15780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M444_RS15830	COG1960	acyl-CoA dehydrogenase activity
M444_RS15835	COG1960	acyl-CoA dehydrogenase activity
M444_RS15845	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS15895	COG1131	(ABC) transporter
M444_RS15925	COG2945	thiolester hydrolase activity
M444_RS15925	COG0596	Alpha beta hydrolase
M444_RS15935	COG4821	SIS domain
M444_RS15945	COG0259	pyridoxamine-phosphate oxidase activity
M444_RS15955	COG1309	transcriptional regulator
M444_RS15975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M444_RS16000	COG0277	FAD linked oxidase domain protein
M444_RS16000	COG0247	lactate metabolic process
M444_RS16005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M444_RS16025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M444_RS16035	COG2252	PERMEase
M444_RS16060	COG0667	Aldo Keto reductase
M444_RS16075	COG2268	Band 7 protein
M444_RS16090	COG2814	Major facilitator Superfamily
M444_RS16100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M444_RS16105	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
M444_RS16110	COG1278	Cold shock
M444_RS16140	COG1061	Type III restriction enzyme res subunit
M444_RS16155	COG3973	AAA domain
M444_RS16195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M444_RS16210	COG0135	phosphoribosylanthranilate isomerase activity
M444_RS16235	COG0463	Glycosyl transferase, family 2
M444_RS16240	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M444_RS16245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M444_RS16245	COG0561	phosphatase activity
M444_RS16260	COG1940	carbohydrate kinase activity
M444_RS16265	COG1228	amidohydrolase
M444_RS16350	COG3842	ATPase activity
M444_RS16360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M444_RS16370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M444_RS16375	COG0215	cysteine-tRNA ligase activity
M444_RS16380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M444_RS16385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M444_RS16390	COG1329	Transcriptional regulator
M444_RS16405	COG5002	protein histidine kinase activity
M444_RS16425	COG0588	phosphoglycerate mutase activity
M444_RS16440	COG0438	transferase activity, transferring glycosyl groups
M444_RS16480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M444_RS16485	COG2890	protein-(glutamine-N5) methyltransferase activity
M444_RS16490	COG1595	DNA-templated transcription, initiation
M444_RS16495	COG4552	Acetyltransferase involved in intracellular survival and related
M444_RS16505	COG1490	D-aminoacyl-tRNA deacylase activity
M444_RS16515	COG0735	belongs to the Fur family
M444_RS16520	COG3485	protocatechuate 3,4-dioxygenase
M444_RS16575	COG0745	RESPONSE REGULATOR receiver
M444_RS16580	COG1609	Transcriptional regulator
M444_RS16585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M444_RS16590	COG0745	RESPONSE REGULATOR receiver
M444_RS16600	COG0823	Involved in the tonB-independent uptake of proteins
M444_RS16610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M444_RS16615	COG0737	Belongs to the 5'-nucleotidase family
M444_RS16620	COG0456	acetyltransferase
M444_RS16625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M444_RS16655	COG0306	phosphate transporter
M444_RS16665	COG1937	Protein conserved in bacteria
M444_RS16690	COG0671	phosphoesterase, PA-phosphatase related
M444_RS16695	COG0739	heme binding
M444_RS16695	COG0741	lytic transglycosylase activity
M444_RS16695	COG1196	nuclear chromosome segregation
M444_RS16705	COG1280	lysine exporter protein (LysE YggA)
M444_RS16715	COG1357	PFAM Pentapeptide repeats (8 copies)
M444_RS16830	COG1252	NADH dehydrogenase
M444_RS16860	COG0579	oxidoreductase
M444_RS16865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M444_RS16875	COG0741	lytic transglycosylase activity
M444_RS16875	COG0739	heme binding
M444_RS16875	COG1196	nuclear chromosome segregation
M444_RS16895	COG0513	Belongs to the DEAD box helicase family
M444_RS16905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M444_RS16910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M444_RS16935	COG0785	Cytochrome C biogenesis protein
M444_RS16950	COG1643	Atp-dependent helicase
M444_RS16980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M444_RS17005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M444_RS17010	COG0047	phosphoribosylformylglycinamidine synthase activity
M444_RS17015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M444_RS17035	COG1131	(ABC) transporter
M444_RS17045	COG3850	Histidine kinase
M444_RS17050	COG2197	response regulator
M444_RS17060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M444_RS17075	COG0151	Belongs to the GarS family
M444_RS17115	COG1309	transcriptional regulator
M444_RS17125	COG3835	regulator
M444_RS17155	COG0433	COG0433 Predicted ATPase
M444_RS17170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M444_RS17210	COG1191	sigma factor activity
M444_RS17250	COG2205	protein histidine kinase activity
M444_RS17255	COG0745	RESPONSE REGULATOR receiver
M444_RS17300	COG0745	RESPONSE REGULATOR receiver
M444_RS17310	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS17315	COG1595	DNA-templated transcription, initiation
M444_RS17330	COG1960	acyl-CoA dehydrogenase activity
M444_RS17340	COG1960	acyl-CoA dehydrogenase activity
M444_RS17370	COG2855	membrane
M444_RS17385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M444_RS17400	COG0653	protein targeting
M444_RS17420	COG0006	proline dipeptidase activity
M444_RS17450	COG2372	response to copper ion
M444_RS17455	COG2837	iron assimilation
M444_RS17465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M444_RS17470	COG0561	phosphatase activity
M444_RS17495	COG1131	(ABC) transporter
M444_RS17510	COG0789	Transcriptional regulator
M444_RS17520	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
M444_RS17525	COG0326	Molecular chaperone. Has ATPase activity
M444_RS17540	COG0561	phosphatase activity
M444_RS17550	COG4988	ABC transporter
M444_RS17555	COG1294	oxidase, subunit
M444_RS17560	COG1271	oxidase subunit
M444_RS17565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M444_RS17570	COG1609	Transcriptional regulator
M444_RS17585	COG0667	Aldo Keto reductase
M444_RS17590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M444_RS17615	COG0662	Cupin 2, conserved barrel domain protein
M444_RS17620	COG1950	PFAM Membrane protein of
M444_RS17625	COG0626	cystathionine gamma-synthase activity
M444_RS17655	COG0456	acetyltransferase
M444_RS17670	COG0305	Participates in initiation and elongation during chromosome replication
M444_RS17675	COG0534	Mate efflux family protein
M444_RS17680	COG0359	binds to the 23S rRNA
M444_RS17685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M444_RS17690	COG0629	single-stranded DNA binding
M444_RS17695	COG0360	Binds together with S18 to 16S ribosomal RNA
M444_RS17720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M444_RS17740	COG0617	tRNA 3'-terminal CCA addition
M444_RS17760	COG1595	DNA-templated transcription, initiation
M444_RS17770	COG0492	ferredoxin-NADP+ reductase activity
M444_RS17775	COG3118	belongs to the thioredoxin family
M444_RS17790	COG1192	Involved in chromosome partitioning
M444_RS17795	COG0357	Ribosomal RNA small subunit methyltransferase G
M444_RS17805	COG0706	membrane insertase activity
M444_RS17810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M444_RS17815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M444_RS17820	COG0592	DNA-directed DNA polymerase activity
M444_RS17825	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M444_RS17830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M444_RS17835	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
M444_RS17845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M444_RS17865	COG0515	serine threonine protein kinase
M444_RS17895	COG0705	Rhomboid family
M444_RS17895	COG0457	Tetratricopeptide repeat
M444_RS17910	COG3764	Sortase (surface protein transpeptidase)
M444_RS17925	COG3764	Sortase (surface protein transpeptidase)
M444_RS17930	COG3764	Sortase (surface protein transpeptidase)
M444_RS17935	COG0515	serine threonine protein kinase
M444_RS17945	COG0772	Belongs to the SEDS family
M444_RS17955	COG1716	ATPase activity
M444_RS17960	COG1716	ATPase activity
M444_RS17970	COG4585	Histidine kinase
M444_RS17975	COG2197	response regulator
M444_RS18000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M444_RS18005	COG2151	metal-sulfur cluster biosynthetic enzyme
M444_RS18010	COG3396	Phenylacetate-CoA oxygenase
M444_RS18015	COG3460	Phenylacetate-CoA oxygenase
M444_RS18020	COG3396	Phenylacetate-CoA oxygenase
M444_RS18045	COG1250	3-hydroxyacyl-CoA dehydrogenase
M444_RS18050	COG1309	transcriptional regulator
M444_RS18055	COG1522	sequence-specific DNA binding
M444_RS18075	COG0604	alcohol dehydrogenase
M444_RS18075	COG3321	synthase
M444_RS18075	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS18080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M444_RS18090	COG0746	molybdenum cofactor guanylyltransferase activity
M444_RS18105	COG4591	ABC-type transport system involved in lipoprotein release permease component
M444_RS18105	COG1136	(ABC) transporter
M444_RS18120	COG0515	serine threonine protein kinase
M444_RS18125	COG0515	serine threonine protein kinase
M444_RS18145	COG0022	dehydrogenase e1 component
M444_RS18150	COG0508	dehydrogenase complex catalyzes the overall conversion of
M444_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS18190	COG1802	Transcriptional regulator
M444_RS18195	COG2271	Major facilitator Superfamily
M444_RS18245	COG1362	aminopeptidase activity
M444_RS18255	COG1960	acyl-CoA dehydrogenase activity
M444_RS18280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M444_RS18295	COG2205	protein histidine kinase activity
M444_RS18305	COG1289	transmembrane transporter activity
M444_RS18365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M444_RS18370	COG1191	sigma factor activity
M444_RS18400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M444_RS18405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M444_RS18410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M444_RS18425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M444_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS18455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M444_RS18465	COG2264	protein methyltransferase activity
M444_RS18490	COG2197	response regulator
M444_RS18600	COG0438	transferase activity, transferring glycosyl groups
M444_RS18620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M444_RS18670	COG0305	Participates in initiation and elongation during chromosome replication
M444_RS18700	COG2217	Heavy metal translocating P-type atpase
M444_RS18730	COG0717	Belongs to the dCTP deaminase family
M444_RS18750	COG2181	nitrate reductase activity
M444_RS18750	COG0247	lactate metabolic process
M444_RS18760	COG0443	Heat shock 70 kDa protein
M444_RS18765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M444_RS18770	COG0484	heat shock protein binding
M444_RS18775	COG0789	Transcriptional regulator
M444_RS18795	COG0542	response to heat
M444_RS18830	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M444_RS18845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M444_RS18850	COG0191	fructose-bisphosphate aldolase activity
M444_RS18910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M444_RS18925	COG1131	(ABC) transporter
M444_RS18930	COG3559	Exporter of polyketide antibiotics
M444_RS18940	COG2197	response regulator
M444_RS18950	COG2197	response regulator
M444_RS18955	COG4585	Histidine kinase
M444_RS18985	COG0693	protein deglycase activity
M444_RS18990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M444_RS19010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M444_RS19015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M444_RS19035	COG1595	DNA-templated transcription, initiation
M444_RS19055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M444_RS19065	COG0438	transferase activity, transferring glycosyl groups
M444_RS19075	COG0438	transferase activity, transferring glycosyl groups
M444_RS19080	COG0402	S-adenosylhomocysteine deaminase activity
M444_RS19100	COG1408	metallophosphoesterase
M444_RS19110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M444_RS19120	COG0003	Pfam Anion-transporting ATPase
M444_RS19140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS19175	COG0596	Alpha beta hydrolase
M444_RS19185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M444_RS19190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M444_RS19255	COG1205	dead DEAH box helicase
M444_RS19255	COG1111	helicase
M444_RS19260	COG1366	Belongs to the anti-sigma-factor antagonist family
M444_RS19265	COG2172	sigma factor antagonist activity
M444_RS19270	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M444_RS19280	COG2890	protein-(glutamine-N5) methyltransferase activity
M444_RS19290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M444_RS19290	COG1754	DNA topoisomerase type I activity
M444_RS19295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M444_RS19300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M444_RS19315	COG1011	Hydrolase
M444_RS19350	COG0105	UTP biosynthetic process
M444_RS19390	COG0477	Major facilitator Superfamily
M444_RS19395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M444_RS19405	COG0456	acetyltransferase
M444_RS19420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M444_RS19420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M444_RS19430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M444_RS19455	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS19460	COG2318	DinB family
M444_RS19470	COG0586	Pfam SNARE associated Golgi protein
M444_RS19480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M444_RS19485	COG2027	D-alanyl-D-alanine carboxypeptidase
M444_RS19495	COG0037	tRNA processing
M444_RS19500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M444_RS19510	COG0302	gtp cyclohydrolase
M444_RS19530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M444_RS19545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M444_RS19545	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M444_RS19560	COG1174	glycine betaine transport
M444_RS19570	COG1732	Glycine betaine
M444_RS19590	COG0649	NAD binding
M444_RS19630	COG2197	response regulator
M444_RS19655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M444_RS19665	COG2843	Capsule synthesis protein
M444_RS19675	COG2234	aminopeptidase activity
M444_RS19700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M444_RS19705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M444_RS19715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M444_RS19755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M444_RS19775	COG0739	heme binding
M444_RS19785	COG2205	protein histidine kinase activity
M444_RS19790	COG0745	RESPONSE REGULATOR receiver
M444_RS19800	COG1595	DNA-templated transcription, initiation
M444_RS19805	COG1194	a g-specific adenine glycosylase
M444_RS19810	COG0671	phosphoesterase, PA-phosphatase related
M444_RS19820	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M444_RS19840	COG0248	Ppx GppA phosphatase
M444_RS19845	COG1082	Xylose isomerase domain protein TIM barrel
M444_RS19855	COG0129	dihydroxy-acid dehydratase activity
M444_RS19875	COG1129	ABC transporter
M444_RS19875	COG0842	Transport permease protein
M444_RS19885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M444_RS19890	COG0180	Tryptophanyl-tRNA synthetase
M444_RS19920	COG0123	including yeast histone deacetylase and acetoin utilization protein
M444_RS19965	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M444_RS19970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M444_RS19975	COG0181	hydroxymethylbilane synthase activity
M444_RS19980	COG1648	precorrin-2 dehydrogenase activity
M444_RS19980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M444_RS19985	COG0113	porphobilinogen synthase activity
M444_RS20025	COG0018	arginyl-trna synthetase
M444_RS20030	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M444_RS20050	COG1690	Belongs to the RtcB family
M444_RS20065	COG1742	UPF0060 membrane protein
M444_RS20075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M444_RS20090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M444_RS20095	COG0406	alpha-ribazole phosphatase activity
M444_RS20105	COG0785	Cytochrome C biogenesis protein
M444_RS20110	COG1333	cytochrome c biogenesis protein
M444_RS20115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M444_RS20140	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M444_RS20165	COG0163	prenyltransferase activity
M444_RS20175	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M444_RS20190	COG1301	dicarboxylic acid transport
M444_RS20235	COG1278	Cold shock
M444_RS20240	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
M444_RS20250	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M444_RS20270	COG2226	methyltransferase
M444_RS20275	COG2066	Belongs to the glutaminase family
M444_RS20295	COG0577	efflux transmembrane transporter activity
M444_RS20295	COG1136	(ABC) transporter
M444_RS20300	COG1136	(ABC) transporter
M444_RS20330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M444_RS20335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M444_RS20340	COG0649	NAD binding
M444_RS20350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M444_RS20355	COG1034	ATP synthesis coupled electron transport
M444_RS20360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M444_RS20365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M444_RS20370	COG0839	Belongs to the complex I subunit 6 family
M444_RS20375	COG0713	ATP synthesis coupled electron transport
M444_RS20380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M444_RS20390	COG1007	ATP synthesis coupled electron transport
M444_RS20405	COG0561	phosphatase activity
M444_RS20415	COG0142	geranyltranstransferase activity
M444_RS20445	COG0702	epimerase
M444_RS20450	COG1733	regulation of RNA biosynthetic process
M444_RS20455	COG1013	pyruvate-flavodoxin oxidoreductase activity
M444_RS20460	COG0674	pyruvate-flavodoxin oxidoreductase activity
M444_RS20460	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M444_RS20480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M444_RS20485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M444_RS20490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M444_RS20495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M444_RS20500	COG0839	Belongs to the complex I subunit 6 family
M444_RS20505	COG0713	ATP synthesis coupled electron transport
M444_RS20510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M444_RS20520	COG1007	ATP synthesis coupled electron transport
M444_RS20525	COG0501	Belongs to the peptidase M48B family
M444_RS20530	COG3304	Inner membrane component domain
M444_RS20535	COG0659	secondary active sulfate transmembrane transporter activity
M444_RS20540	COG1666	GTP binding
M444_RS20585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M444_RS20590	COG2030	dehydratase
M444_RS20605	COG0477	Major facilitator Superfamily
M444_RS20610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M444_RS20620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M444_RS20625	COG0436	Aminotransferase
M444_RS20635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M444_RS20650	COG0081	regulation of translation
M444_RS20665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M444_RS20670	COG0222	ribosome binding
M444_RS20675	COG0085	RNA polymerase activity
M444_RS20680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M444_RS20690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M444_RS20695	COG0049	tRNA binding
M444_RS20700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M444_RS20705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M444_RS20715	COG0051	transcription antitermination factor activity, RNA binding
M444_RS20720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M444_RS20725	COG0088	Forms part of the polypeptide exit tunnel
M444_RS20730	COG0089	rRNA binding
M444_RS20735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M444_RS20740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M444_RS20745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M444_RS20750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M444_RS20755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M444_RS20760	COG0255	Belongs to the universal ribosomal protein uL29 family
M444_RS20765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M444_RS20770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M444_RS20775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M444_RS20780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M444_RS20785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M444_RS20790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M444_RS20795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M444_RS20800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M444_RS20805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M444_RS20810	COG1841	ribosomal large subunit assembly
M444_RS20815	COG0200	Binds to the 23S rRNA
M444_RS20820	COG0201	protein transport
M444_RS20825	COG0563	adenylate kinase activity
M444_RS20835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M444_RS20840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M444_RS20845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M444_RS20850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M444_RS20855	COG0202	RNA polymerase activity
M444_RS20860	COG0203	ribosomal protein L17
M444_RS20865	COG0101	tRNA pseudouridine synthase activity
M444_RS20870	COG0488	(ABC) transporter
M444_RS20880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M444_RS20885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M444_RS20890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M444_RS20900	COG1072	(Pantothenic acid kinase))
M444_RS20905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M444_RS20910	COG0736	holo-[acyl-carrier-protein] synthase activity
M444_RS20920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M444_RS20925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M444_RS20930	COG0802	atpase or kinase
M444_RS20955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M444_RS20975	COG0726	polysaccharide deacetylase
M444_RS20980	COG0726	polysaccharide deacetylase
M444_RS20990	COG1316	TRANSCRIPTIONal
M444_RS20995	COG2205	protein histidine kinase activity
M444_RS21000	COG0745	RESPONSE REGULATOR receiver
M444_RS21005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M444_RS21010	COG0459	protein refolding
M444_RS21020	COG4221	oxidoreductase activity
M444_RS21025	COG0583	DNA-binding transcription factor activity
M444_RS21035	COG2197	response regulator
M444_RS21040	COG1595	DNA-templated transcription, initiation
M444_RS21050	COG0516	GMP reductase activity
M444_RS21055	COG2337	Toxic component of a toxin-antitoxin (TA) module
M444_RS21075	COG2815	serine threonine protein kinase
M444_RS21075	COG0515	serine threonine protein kinase
M444_RS21085	COG0515	serine threonine protein kinase
M444_RS21090	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS21115	COG0519	Catalyzes the synthesis of GMP from XMP
M444_RS21115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M444_RS21150	COG2197	response regulator
M444_RS21170	COG0640	Transcriptional regulator
M444_RS21185	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M444_RS21190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS21190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS21205	COG0714	Associated with various cellular activities
M444_RS21215	COG3552	Protein containing von Willebrand factor type A (VWA) domain
M444_RS21220	COG0045	succinate-CoA ligase (ADP-forming) activity
M444_RS21255	COG0138	bifunctional purine biosynthesis protein purh
M444_RS21265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M444_RS21275	COG0039	L-malate dehydrogenase activity
M444_RS21295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M444_RS21300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M444_RS21315	COG0754	glutathionylspermidine amidase activity
M444_RS21320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M444_RS21325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M444_RS21330	COG0180	Tryptophanyl-tRNA synthetase
M444_RS21355	COG1408	metallophosphoesterase
M444_RS21360	COG1309	transcriptional regulator
M444_RS21375	COG0596	Alpha beta hydrolase
M444_RS21385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M444_RS21390	COG1053	succinate dehydrogenase
M444_RS21400	COG2009	succinate dehydrogenase
M444_RS21410	COG1595	DNA-templated transcription, initiation
M444_RS21425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS21425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS21435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M444_RS21445	COG1216	Glycosyl transferase, family 2
M444_RS21455	COG2089	acid synthase
M444_RS21465	COG1473	amidohydrolase
M444_RS21465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M444_RS21470	COG1744	ABC transporter substrate-binding protein PnrA-like
M444_RS21475	COG3845	ABC transporter
M444_RS21480	COG4603	Belongs to the binding-protein-dependent transport system permease family
M444_RS21485	COG1079	Belongs to the binding-protein-dependent transport system permease family
M444_RS21505	COG2814	Major facilitator Superfamily
M444_RS21510	COG0583	DNA-binding transcription factor activity
M444_RS21535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M444_RS21580	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS21600	COG1846	Transcriptional regulator
M444_RS21610	COG1595	DNA-templated transcription, initiation
M444_RS21615	COG0745	RESPONSE REGULATOR receiver
M444_RS21620	COG2205	protein histidine kinase activity
M444_RS21630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M444_RS21650	COG1349	DNA-binding transcription factor activity
M444_RS21655	COG4770	biotin carboxylase activity
M444_RS21665	COG0424	maF-like protein
M444_RS21675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M444_RS21685	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M444_RS21690	COG1024	Enoyl-CoA hydratase
M444_RS21700	COG2986	histidine ammonia-lyase
M444_RS21715	COG1376	ErfK ybiS ycfS ynhG family protein
M444_RS21725	COG1064	alcohol dehydrogenase
M444_RS21730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M444_RS21765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M444_RS21780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M444_RS21795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M444_RS21815	COG1331	Highly conserved protein containing a thioredoxin domain
M444_RS21825	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M444_RS21840	COG0436	Aminotransferase
M444_RS21880	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
M444_RS21890	COG1414	Transcriptional regulator
M444_RS21920	COG2894	cell division
M444_RS21950	COG4585	Histidine kinase
M444_RS21955	COG2197	response regulator
M444_RS21975	COG2885	chlorophyll binding
M444_RS21980	COG1595	DNA-templated transcription, initiation
M444_RS21985	COG1252	NADH dehydrogenase
M444_RS22010	COG0726	polysaccharide deacetylase
M444_RS22040	COG1309	transcriptional regulator
M444_RS22055	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M444_RS22060	COG0667	Aldo Keto reductase
M444_RS22065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M444_RS22070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M444_RS22090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M444_RS22095	COG0450	alkyl hydroperoxide reductase
M444_RS22110	COG1136	(ABC) transporter
M444_RS22130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M444_RS22150	COG0114	fumarate hydratase activity
M444_RS22165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M444_RS22165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M444_RS22190	COG0778	Nitroreductase
M444_RS22195	COG1722	exodeoxyribonuclease VII activity
M444_RS22200	COG1570	exodeoxyribonuclease VII activity
M444_RS22205	COG1113	amino acid transport
M444_RS22210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M444_RS22215	COG1940	carbohydrate kinase activity
M444_RS22225	COG0012	GTP binding
M444_RS22295	COG1842	Phage shock protein A
M444_RS22330	COG1217	gtp-binding protein TYPA
M444_RS22335	COG0747	negative chemotaxis
M444_RS22345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M444_RS22355	COG4608	Belongs to the ABC transporter superfamily
M444_RS22370	COG1132	(ABC) transporter
M444_RS22390	COG4166	transmembrane transport
M444_RS22395	COG0601	transmembrane transport
M444_RS22400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M444_RS22410	COG4608	Belongs to the ABC transporter superfamily
M444_RS22425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M444_RS22440	COG1131	(ABC) transporter
M444_RS22450	COG4585	Histidine kinase
M444_RS22455	COG2197	response regulator
M444_RS22490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M444_RS22495	COG1611	Belongs to the LOG family
M444_RS22510	COG0519	Catalyzes the synthesis of GMP from XMP
M444_RS22515	COG1024	Enoyl-CoA hydratase
M444_RS22525	COG1595	DNA-templated transcription, initiation
M444_RS22535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M444_RS22540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M444_RS22575	COG0598	Magnesium transport protein CorA
M444_RS22595	COG2095	MarC family integral membrane protein
M444_RS22600	COG2267	carboxylic ester hydrolase activity
M444_RS22655	COG0601	transmembrane transport
M444_RS22700	COG3209	COG3209 Rhs family protein
M444_RS22725	COG0210	DNA helicase
M444_RS22730	COG0210	DNA helicase
M444_RS22735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M444_RS22770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M444_RS22830	COG3480	Lon protease (S16) C-terminal proteolytic domain
M444_RS22840	COG1615	UPF0182 protein
M444_RS22865	COG0753	catalase activity
M444_RS22875	COG0483	inositol monophosphate 1-phosphatase activity
M444_RS22885	COG2076	Multidrug Resistance protein
M444_RS22890	COG1162	GTPase activity
M444_RS22895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M444_RS22905	COG2135	peptidase activity
M444_RS22915	COG1595	DNA-templated transcription, initiation
M444_RS22920	COG5662	AntiSigma factor
M444_RS22925	COG2199	diguanylate cyclase activity
M444_RS22925	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M444_RS22940	COG0242	peptide deformylase activity
M444_RS22980	COG1966	Carbon starvation protein
M444_RS22985	COG2188	Transcriptional regulator
M444_RS22990	COG2182	Extracellular solute-binding protein
M444_RS22995	COG1175	transmembrane transport
M444_RS23000	COG0395	ABC-type sugar transport system, permease component
M444_RS23005	COG1472	Belongs to the glycosyl hydrolase 3 family
M444_RS23010	COG0363	glucosamine-6-phosphate deaminase activity
M444_RS23015	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS23020	COG1309	transcriptional regulator
M444_RS23035	COG1597	lipid kinase activity
M444_RS23065	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M444_RS23075	COG1017	nitric oxide dioxygenase activity
M444_RS23075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M444_RS23080	COG1959	2 iron, 2 sulfur cluster binding
M444_RS23085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M444_RS23090	COG0142	geranyltranstransferase activity
M444_RS23110	COG5640	endopeptidase activity
M444_RS23140	COG0604	alcohol dehydrogenase
M444_RS23155	COG0765	amino acid transport
M444_RS23160	COG1126	abc transporter atp-binding protein
M444_RS23225	COG0508	dehydrogenase complex catalyzes the overall conversion of
M444_RS23225	COG0567	Dehydrogenase, E1 component
M444_RS23230	COG2205	protein histidine kinase activity
M444_RS23235	COG0745	RESPONSE REGULATOR receiver
M444_RS23240	COG1131	(ABC) transporter
M444_RS23280	COG2897	thiosulfate sulfurtransferase activity
M444_RS23295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M444_RS23340	COG3883	PFAM NLP P60 protein
M444_RS23340	COG0791	NLP P60 protein
M444_RS23355	COG0772	Belongs to the SEDS family
M444_RS23385	COG2205	protein histidine kinase activity
M444_RS23405	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M444_RS23410	COG1793	dna ligase
M444_RS23410	COG3285	dna ligase
M444_RS23415	COG1793	dna ligase
M444_RS23465	COG0019	diaminopimelate decarboxylase activity
M444_RS23470	COG0460	homoserine dehydrogenase
M444_RS23475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M444_RS23480	COG0083	homoserine kinase activity
M444_RS23490	COG1316	TRANSCRIPTIONal
M444_RS23495	COG0254	rRNA binding
M444_RS23500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M444_RS23505	COG2890	protein-(glutamine-N5) methyltransferase activity
M444_RS23515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M444_RS23520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M444_RS23540	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M444_RS23545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M444_RS23550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M444_RS23555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M444_RS23560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M444_RS23565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M444_RS23570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M444_RS23585	COG2197	response regulator
M444_RS23590	COG4585	Histidine kinase
M444_RS23605	COG1250	3-hydroxyacyl-CoA dehydrogenase
M444_RS23625	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M444_RS23650	COG1131	(ABC) transporter
M444_RS23660	COG1131	(ABC) transporter
M444_RS23680	COG0183	Belongs to the thiolase family
M444_RS23745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS23745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS23750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M444_RS23760	COG0189	ligase activity
M444_RS23775	COG1181	Belongs to the D-alanine--D-alanine ligase family
M444_RS23780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M444_RS23785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M444_RS23830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M444_RS23835	COG0280	phosphate acetyltransferase
M444_RS23835	COG0857	belongs to the CobB CobQ family
M444_RS23840	COG0205	6-phosphofructokinase activity
M444_RS23875	COG0366	Alpha amylase catalytic
M444_RS23880	COG0058	SHG alpha-glucan phosphorylase activity
M444_RS23905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M444_RS23910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M444_RS23915	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M444_RS23955	COG0489	protein tyrosine kinase activity
M444_RS23960	COG0297	glycogen (starch) synthase activity
M444_RS23980	COG1846	Transcriptional regulator
M444_RS24040	COG1122	ATPase activity
M444_RS24050	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
M444_RS24055	COG0310	cobalt ion transport
M444_RS24070	COG1760	l-serine dehydratase
M444_RS24075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M444_RS24080	COG0509	glycine decarboxylation via glycine cleavage system
M444_RS24085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M444_RS24105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M444_RS24110	COG0747	negative chemotaxis
M444_RS24120	COG0444	Belongs to the ABC transporter superfamily
M444_RS24125	COG4608	Belongs to the ABC transporter superfamily
M444_RS24130	COG2860	membrane
M444_RS24150	COG0482	sulfurtransferase activity
M444_RS24155	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS24155	COG0604	alcohol dehydrogenase
M444_RS24155	COG3321	synthase
M444_RS24165	COG1404	Belongs to the peptidase S8 family
M444_RS24180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M444_RS24190	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M444_RS24195	COG0154	amidase activity
M444_RS24205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M444_RS24220	COG1132	(ABC) transporter
M444_RS24220	COG2375	cellular response to nickel ion
M444_RS24225	COG2318	DinB family
M444_RS24240	COG2409	Drug exporters of the RND superfamily
M444_RS24245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M444_RS24255	COG2197	response regulator
M444_RS24265	COG2133	pyrroloquinoline quinone binding
M444_RS24270	COG0667	Aldo Keto reductase
M444_RS24290	COG0440	acetolactate synthase activity
M444_RS24295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M444_RS24300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M444_RS24305	COG0477	Major facilitator Superfamily
M444_RS24320	COG3835	regulator
M444_RS24325	COG0506	proline dehydrogenase activity
M444_RS24330	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS24335	COG0778	Nitroreductase
M444_RS24335	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
M444_RS24350	COG3511	phospholipase C
M444_RS24355	COG2130	NADP-dependent
M444_RS24360	COG0583	DNA-binding transcription factor activity
M444_RS24365	COG0473	3-isopropylmalate dehydrogenase activity
M444_RS24370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M444_RS24385	COG0831	urea catabolic process
M444_RS24385	COG0832	Belongs to the urease beta subunit family
M444_RS24390	COG0804	urea catabolic process
M444_RS24395	COG2957	Belongs to the agmatine deiminase family
M444_RS24400	COG1309	transcriptional regulator
M444_RS24405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M444_RS24420	COG2353	YceI-like domain
M444_RS24425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M444_RS24445	COG2018	Roadblock/LC7 domain
M444_RS24465	COG2018	Roadblock/LC7 domain
M444_RS24470	COG5002	protein histidine kinase activity
M444_RS24480	COG0179	Fumarylacetoacetate (FAA) hydrolase
M444_RS24485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M444_RS24495	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
M444_RS24530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M444_RS24535	COG0066	3-isopropylmalate dehydratase activity
M444_RS24545	COG0776	regulation of translation
M444_RS24550	COG1920	GTP binding
M444_RS24560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M444_RS24565	COG1181	Belongs to the D-alanine--D-alanine ligase family
M444_RS24585	COG0351	phosphomethylpyrimidine kinase
M444_RS24590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M444_RS24595	COG1461	Dihydroxyacetone kinase
M444_RS24600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M444_RS24605	COG0742	ribosomal rna small subunit methyltransferase
M444_RS24610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M444_RS24625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M444_RS24630	COG0571	ribonuclease III activity
M444_RS24635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M444_RS24640	COG1733	regulation of RNA biosynthetic process
M444_RS24645	COG2340	Cysteine-rich secretory protein family
M444_RS24650	COG1254	Belongs to the acylphosphatase family
M444_RS24660	COG1196	nuclear chromosome segregation
M444_RS24665	COG0477	Major facilitator Superfamily
M444_RS24705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M444_RS24715	COG3457	Alanine racemase
M444_RS24720	COG0626	cystathionine gamma-synthase activity
M444_RS24725	COG1735	metal-dependent hydrolase with the TIM-barrel fold
M444_RS24745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M444_RS24755	COG0442	prolyl-tRNA aminoacylation
M444_RS24765	COG0228	four-way junction DNA binding
M444_RS24770	COG1837	Belongs to the UPF0109 family
M444_RS24775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M444_RS24780	COG0336	Belongs to the RNA methyltransferase TrmD family
M444_RS24785	COG0335	large ribosomal subunit rRNA binding
M444_RS24790	COG0681	Belongs to the peptidase S26 family
M444_RS24795	COG0681	Belongs to the peptidase S26 family
M444_RS24820	COG0792	nuclease activity
M444_RS24835	COG0210	DNA helicase
M444_RS24895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M444_RS24945	COG1191	sigma factor activity
M444_RS24955	COG0052	Belongs to the universal ribosomal protein uS2 family
M444_RS24960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M444_RS24965	COG0528	UMP kinase activity
M444_RS24970	COG0233	cytoplasmic translational termination
M444_RS24980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M444_RS24995	COG3842	ATPase activity
M444_RS25015	COG1136	(ABC) transporter
M444_RS25020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M444_RS25030	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS25050	COG2197	response regulator
M444_RS25055	COG4585	Histidine kinase
M444_RS25065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M444_RS25085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M444_RS25090	COG3842	ATPase activity
M444_RS25095	COG1176	ABC-type spermidine putrescine transport system, permease component I
M444_RS25100	COG1177	transmembrane transport
M444_RS25105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M444_RS25130	COG2508	Transcriptional regulator
M444_RS25150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M444_RS25155	COG0750	zinc metalloprotease
M444_RS25160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M444_RS25175	COG0442	prolyl-tRNA aminoacylation
M444_RS25180	COG0330	HflC and HflK could
M444_RS25200	COG0779	Required for maturation of 30S ribosomal subunits
M444_RS25215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M444_RS25225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M444_RS25230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M444_RS25260	COG1404	Belongs to the peptidase S8 family
M444_RS25285	COG1674	ftsk spoiiie
M444_RS25295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M444_RS25300	COG1185	polyribonucleotide nucleotidyltransferase activity
M444_RS25305	COG0612	Peptidase, M16
M444_RS25310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M444_RS25330	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M444_RS25335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M444_RS25340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M444_RS25365	COG2318	DinB family
M444_RS25375	COG2205	protein histidine kinase activity
M444_RS25375	COG4999	Histidine kinase
M444_RS25375	COG3437	response regulator, receiver
M444_RS25375	COG3850	Histidine kinase
M444_RS25385	COG1674	ftsk spoiiie
M444_RS25395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M444_RS25405	COG1546	Belongs to the CinA family
M444_RS25405	COG1058	Belongs to the CinA family
M444_RS25410	COG1396	sequence-specific DNA binding
M444_RS25415	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS25420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M444_RS25430	COG1201	RNA secondary structure unwinding
M444_RS25435	COG1917	Cupin 2, conserved barrel domain protein
M444_RS25435	COG2207	Transcriptional regulator
M444_RS25470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M444_RS25480	COG2897	thiosulfate sulfurtransferase activity
M444_RS25495	COG0765	amino acid transport
M444_RS25500	COG0765	amino acid transport
M444_RS25505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M444_RS25510	COG1126	abc transporter atp-binding protein
M444_RS25515	COG0745	RESPONSE REGULATOR receiver
M444_RS25520	COG2205	protein histidine kinase activity
M444_RS25535	COG1609	Transcriptional regulator
M444_RS25550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M444_RS25570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M444_RS25580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M444_RS25585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M444_RS25595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M444_RS25630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M444_RS25635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M444_RS25640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M444_RS25660	COG0588	phosphoglycerate mutase activity
M444_RS25685	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M444_RS25720	COG1136	(ABC) transporter
M444_RS25730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M444_RS25755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M444_RS25760	COG4565	transcriptional regulatory protein
M444_RS25765	COG3290	protein histidine kinase activity
M444_RS25790	COG0372	Belongs to the citrate synthase family
M444_RS25805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M444_RS25810	COG0612	Peptidase, M16
M444_RS25825	COG1802	Transcriptional regulator
M444_RS25830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M444_RS25850	COG1435	thymidine kinase activity
M444_RS25885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M444_RS25895	COG0745	RESPONSE REGULATOR receiver
M444_RS25900	COG2205	protein histidine kinase activity
M444_RS25925	COG0756	dUTP diphosphatase activity
M444_RS25960	COG0569	domain protein
M444_RS25965	COG0531	amino acid
M444_RS25970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M444_RS25980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M444_RS25980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS25995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M444_RS26000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M444_RS26005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS26015	COG0730	response to heat
M444_RS26020	COG1937	Protein conserved in bacteria
M444_RS26035	COG0210	DNA helicase
M444_RS26045	COG1401	restriction endodeoxyribonuclease activity
M444_RS26070	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M444_RS26075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M444_RS26080	COG0515	serine threonine protein kinase
M444_RS26080	COG2815	serine threonine protein kinase
M444_RS26145	COG0252	asparaginase activity
M444_RS26175	COG0431	NADPH-dependent FMN reductase
M444_RS26190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M444_RS26195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS26210	COG1799	cell septum assembly
M444_RS26235	COG2040	homocysteine
M444_RS26240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M444_RS26255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M444_RS26265	COG1024	Enoyl-CoA hydratase
M444_RS26285	COG1960	acyl-CoA dehydrogenase activity
M444_RS26300	COG0006	proline dipeptidase activity
M444_RS26310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M444_RS26330	COG3938	Belongs to the proline racemase family
M444_RS26360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M444_RS26365	COG0601	transmembrane transport
M444_RS26375	COG4608	Belongs to the ABC transporter superfamily
M444_RS26400	COG0494	nUDIX hydrolase
M444_RS26410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M444_RS26415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M444_RS26420	COG1609	Transcriptional regulator
M444_RS26425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M444_RS26430	COG1653	transport
M444_RS26435	COG1175	transmembrane transport
M444_RS26440	COG0395	ABC-type sugar transport system, permease component
M444_RS26450	COG1940	carbohydrate kinase activity
M444_RS26455	COG4213	ABC transporter substrate-binding protein
M444_RS26465	COG1172	Belongs to the binding-protein-dependent transport system permease family
M444_RS26470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M444_RS26475	COG0531	amino acid
M444_RS26480	COG1316	TRANSCRIPTIONal
M444_RS26490	COG1250	3-hydroxyacyl-CoA dehydrogenase
M444_RS26490	COG1024	Enoyl-CoA hydratase
M444_RS26495	COG0183	Belongs to the thiolase family
M444_RS26520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M444_RS26535	COG0446	pyridine nucleotide-disulphide oxidoreductase
M444_RS26545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M444_RS26550	COG3253	May function as heme-dependent peroxidase
M444_RS26555	COG0596	Alpha beta hydrolase
M444_RS26565	COG3220	belongs to the UPF0276 family
M444_RS26580	COG1116	anion transmembrane transporter activity
M444_RS26600	COG2326	polyphosphate kinase activity
M444_RS26630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M444_RS26635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M444_RS26650	COG3511	phospholipase C
M444_RS26665	COG0504	CTP synthase activity
M444_RS26685	COG2226	methyltransferase
M444_RS26730	COG0515	serine threonine protein kinase
M444_RS26760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M444_RS26770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M444_RS26775	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M444_RS26795	COG0529	Catalyzes the synthesis of activated sulfate
M444_RS26800	COG0175	sulfate reduction
M444_RS26820	COG0456	acetyltransferase
M444_RS26820	COG1846	Transcriptional regulator
M444_RS26830	COG1960	acyl-CoA dehydrogenase activity
M444_RS26845	COG1162	GTPase activity
M444_RS26870	COG0028	Belongs to the TPP enzyme family
M444_RS26890	COG1802	Transcriptional regulator
M444_RS26915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M444_RS26920	COG2252	PERMEase
M444_RS26930	COG4552	Acetyltransferase involved in intracellular survival and related
M444_RS27000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M444_RS27045	COG0596	Alpha beta hydrolase
M444_RS27050	COG0475	glutathione-regulated potassium exporter activity
M444_RS27060	COG2255	four-way junction helicase activity
M444_RS27110	COG0598	Magnesium transport protein CorA
M444_RS27120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M444_RS27125	COG0386	Belongs to the glutathione peroxidase family
M444_RS27135	COG3960	tartronate-semialdehyde synthase activity
M444_RS27140	COG0277	FAD linked oxidase domain protein
M444_RS27160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M444_RS27165	COG2197	response regulator
M444_RS27170	COG4585	Histidine kinase
M444_RS27180	COG0753	catalase activity
M444_RS27185	COG2084	Dehydrogenase
M444_RS27190	COG3622	Belongs to the hyi family
M444_RS27210	COG2351	hydroxyisourate hydrolase activity
M444_RS27225	COG2233	PERMEase
M444_RS27245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M444_RS27265	COG2197	response regulator
M444_RS27270	COG4585	Histidine kinase
M444_RS27280	COG1136	(ABC) transporter
M444_RS27285	COG1414	Transcriptional regulator
M444_RS27290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M444_RS27295	COG4266	Belongs to the allantoicase family
M444_RS27315	COG0673	inositol 2-dehydrogenase activity
M444_RS27330	COG1129	ABC transporter
M444_RS27335	COG1940	carbohydrate kinase activity
M444_RS27360	COG1126	abc transporter atp-binding protein
M444_RS27365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M444_RS27370	COG0765	amino acid transport
M444_RS27375	COG0765	amino acid transport
M444_RS27405	COG1376	ErfK ybiS ycfS ynhG family protein
M444_RS27415	COG0745	RESPONSE REGULATOR receiver
M444_RS27420	COG2205	protein histidine kinase activity
M444_RS27440	COG0405	Gamma-glutamyltransferase
M444_RS27470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M444_RS27475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M444_RS27490	COG4104	PAAR repeat-containing protein
M444_RS27490	COG3209	COG3209 Rhs family protein
M444_RS27500	COG0483	inositol monophosphate 1-phosphatase activity
M444_RS27515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M444_RS27535	COG1335	isochorismatase
M444_RS27545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M444_RS27560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M444_RS27565	COG1929	Belongs to the glycerate kinase type-1 family
M444_RS27575	COG0688	phosphatidylethanolamine metabolic process
M444_RS27580	COG1960	acyl-CoA dehydrogenase activity
M444_RS27595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS27595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M444_RS27600	COG0604	alcohol dehydrogenase
M444_RS27610	COG1250	3-hydroxyacyl-CoA dehydrogenase
M444_RS27635	COG2362	D-Aminopeptidase
M444_RS27640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M444_RS27665	COG2226	methyltransferase
M444_RS27700	COG0531	amino acid
M444_RS27710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M444_RS27720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M444_RS27745	COG2154	pterin-4-alpha-carbinolamine dehydratase
M444_RS27755	COG0656	L-ascorbic acid biosynthetic process
M444_RS27780	COG1022	Amp-dependent synthetase and ligase
M444_RS27800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M444_RS27805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M444_RS27820	COG0515	serine threonine protein kinase
M444_RS27820	COG2815	serine threonine protein kinase
M444_RS27840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M444_RS27845	COG1288	antiporter activity
M444_RS27890	COG1486	melibiose metabolic process
M444_RS27900	COG0494	nUDIX hydrolase
M444_RS27920	COG1793	dna ligase
M444_RS27965	COG0488	(ABC) transporter
M444_RS27990	COG1515	deoxyribonuclease V activity
M444_RS27995	COG3268	Saccharopine dehydrogenase
M444_RS28005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M444_RS28010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS28015	COG1960	acyl-CoA dehydrogenase activity
M444_RS28020	COG0183	Belongs to the thiolase family
M444_RS28025	COG1024	Enoyl-CoA hydratase
M444_RS28025	COG1250	3-hydroxyacyl-CoA dehydrogenase
M444_RS28035	COG0789	Transcriptional regulator
M444_RS28075	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS28100	COG0300	oxidoreductase activity
M444_RS28110	COG4977	sequence-specific DNA binding
M444_RS28120	COG1024	Enoyl-CoA hydratase
M444_RS28130	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M444_RS28150	COG0371	Dehydrogenase
M444_RS28170	COG1134	teichoic acid transport
M444_RS28175	COG1562	ergosterol biosynthetic process
M444_RS28185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M444_RS28195	COG1657	PFAM Prenyltransferase squalene oxidase
M444_RS28215	COG2365	Tyrosine phosphatase family
M444_RS28225	COG2755	lipolytic protein G-D-S-L family
M444_RS28270	COG3958	Transketolase
M444_RS28275	COG3959	Transketolase, thiamine diphosphate binding domain
M444_RS28295	COG0583	DNA-binding transcription factor activity
M444_RS28305	COG1335	isochorismatase
M444_RS28330	COG0747	negative chemotaxis
M444_RS28335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M444_RS28350	COG2318	DinB family
M444_RS28355	COG0673	inositol 2-dehydrogenase activity
M444_RS28360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M444_RS28370	COG1968	undecaprenyl-diphosphatase activity
M444_RS28385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M444_RS28435	COG0110	maltose O-acetyltransferase activity
M444_RS28450	COG1832	CoA-binding protein
M444_RS28455	COG1739	Uncharacterized protein family UPF0029
M444_RS28475	COG2274	protein secretion by the type I secretion system
M444_RS28490	COG0420	3'-5' exonuclease activity
M444_RS28495	COG0419	ATPase involved in DNA repair
M444_RS28500	COG1522	sequence-specific DNA binding
M444_RS28530	COG2188	Transcriptional regulator
M444_RS28540	COG2197	response regulator
M444_RS28545	COG4585	Histidine kinase
M444_RS28570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M444_RS28590	COG2226	methyltransferase
M444_RS28595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M444_RS28600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M444_RS28605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M444_RS28630	COG0831	urea catabolic process
M444_RS28635	COG0832	Belongs to the urease beta subunit family
M444_RS28640	COG0804	urea catabolic process
M444_RS28645	COG0830	nickel cation binding
M444_RS28650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M444_RS28655	COG0829	nickel cation binding
M444_RS28680	COG0205	6-phosphofructokinase activity
M444_RS28685	COG3442	glutamine amidotransferase
M444_RS28695	COG0242	peptide deformylase activity
M444_RS28705	COG1960	acyl-CoA dehydrogenase activity
M444_RS28800	COG0243	molybdopterin cofactor binding
M444_RS28830	COG0514	ATP-dependent DNA helicase (RecQ)
M444_RS28835	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS28845	COG4175	Glycine betaine
M444_RS28845	COG0517	IMP dehydrogenase activity
M444_RS28850	COG4176	ABC-type proline glycine betaine transport system permease component
M444_RS28860	COG0515	serine threonine protein kinase
M444_RS28885	COG1505	serine-type exopeptidase activity
M444_RS28935	COG1404	Belongs to the peptidase S8 family
M444_RS28950	COG0483	inositol monophosphate 1-phosphatase activity
M444_RS28980	COG2814	Major facilitator Superfamily
M444_RS29000	COG1012	belongs to the aldehyde dehydrogenase family
M444_RS29070	COG2018	Roadblock/LC7 domain
M444_RS29080	COG3012	SEC-C Motif Domain Protein
M444_RS29085	COG1946	Acyl-CoA thioesterase
M444_RS29100	COG1132	(ABC) transporter
M444_RS29105	COG1132	(ABC) transporter
M444_RS29120	COG1132	(ABC) transporter
M444_RS29130	COG2072	flavoprotein involved in K transport
M444_RS29135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M444_RS29145	COG0702	epimerase
M444_RS29170	COG0588	phosphoglycerate mutase activity
M444_RS29230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M444_RS29245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M444_RS29275	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M444_RS29290	COG1335	isochorismatase
M444_RS29300	COG0783	Belongs to the Dps family
M444_RS29305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M444_RS29310	COG2267	carboxylic ester hydrolase activity
M444_RS29340	COG0438	transferase activity, transferring glycosyl groups
M444_RS29350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M444_RS29355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M444_RS29380	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M444_RS29420	COG4762	Protein conserved in bacteria
M444_RS29440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M444_RS29475	COG0726	polysaccharide deacetylase
M444_RS29515	COG1309	transcriptional regulator
M444_RS29535	COG0583	DNA-binding transcription factor activity
M444_RS29545	COG1053	succinate dehydrogenase
M444_RS29550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M444_RS29565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M444_RS29575	COG3360	Dodecin
M444_RS29580	COG2182	Extracellular solute-binding protein
M444_RS29590	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M444_RS29595	COG0121	glutamine amidotransferase
M444_RS29600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M444_RS29605	COG3572	ergothioneine biosynthetic process
M444_RS29630	COG1609	Transcriptional regulator
M444_RS29635	COG0183	Belongs to the thiolase family
M444_RS29645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M444_RS29690	COG2813	Specifically methylates the guanine in position
M444_RS29725	COG3293	Transposase
M444_RS29735	COG0017	Asparaginyl-tRNA synthetase
M444_RS29755	COG4106	trans-aconitate 2-methyltransferase activity
M444_RS29770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M444_RS29785	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
M444_RS29795	COG0494	nUDIX hydrolase
M444_RS29830	COG4221	oxidoreductase activity
M444_RS29835	COG0022	dehydrogenase e1 component
M444_RS29840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M444_RS29845	COG2192	nodulation
M444_RS29860	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M444_RS29865	COG0667	Aldo Keto reductase
M444_RS29885	COG1472	Belongs to the glycosyl hydrolase 3 family
M444_RS29925	COG2124	cytochrome p450
M444_RS29940	COG3510	cephalosporin hydroxylase
M444_RS29945	COG1819	glycosyl
M444_RS29950	COG2226	methyltransferase
M444_RS29980	COG2124	cytochrome p450
M444_RS29985	COG1819	glycosyl
M444_RS29990	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS30010	COG3547	Transposase (IS116 IS110 IS902 family)
M444_RS30015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M444_RS30025	COG0254	rRNA binding
M444_RS30035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M444_RS30040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M444_RS30060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M444_RS30065	COG2372	response to copper ion
M444_RS30095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M444_RS30100	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M444_RS30110	COG0531	amino acid
M444_RS30125	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M444_RS30130	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M444_RS30135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M444_RS30170	COG4221	oxidoreductase activity
M444_RS30190	COG0156	8-amino-7-oxononanoate synthase activity
M444_RS30205	COG1428	Deoxynucleoside kinase
M444_RS30230	COG1132	(ABC) transporter
M444_RS30235	COG1132	(ABC) transporter
M444_RS30245	COG0515	serine threonine protein kinase
M444_RS30255	COG0477	Major facilitator Superfamily
M444_RS30285	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS30310	COG0745	RESPONSE REGULATOR receiver
M444_RS30315	COG2205	protein histidine kinase activity
M444_RS30320	COG2340	Cysteine-rich secretory protein family
M444_RS30330	COG2197	response regulator
M444_RS30375	COG0477	Major facilitator Superfamily
M444_RS30410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M444_RS30420	COG3290	protein histidine kinase activity
M444_RS30490	COG0393	Putative heavy-metal-binding
M444_RS30550	COG2814	Major facilitator Superfamily
M444_RS30565	COG2356	endonuclease I
M444_RS30575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M444_RS30600	COG3864	Putative metallopeptidase domain
M444_RS30635	COG0515	serine threonine protein kinase
M444_RS30635	COG2815	serine threonine protein kinase
M444_RS30640	COG4585	Histidine kinase
M444_RS30645	COG2197	response regulator
M444_RS30680	COG1024	Enoyl-CoA hydratase
M444_RS30700	COG1960	acyl-CoA dehydrogenase activity
M444_RS30705	COG1960	acyl-CoA dehydrogenase activity
M444_RS30715	COG2304	oxidoreductase activity
M444_RS30735	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M444_RS30740	COG3511	phospholipase C
M444_RS30770	COG1301	dicarboxylic acid transport
M444_RS30775	COG3290	protein histidine kinase activity
M444_RS30780	COG4565	transcriptional regulatory protein
M444_RS30795	COG0076	glutamate decarboxylase activity
M444_RS30820	COG1414	Transcriptional regulator
M444_RS30835	COG0667	Aldo Keto reductase
M444_RS30885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M444_RS30890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M444_RS30900	COG0667	Aldo Keto reductase
M444_RS30905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M444_RS30915	COG1131	(ABC) transporter
M444_RS30920	COG1793	dna ligase
M444_RS30940	COG0477	Major facilitator Superfamily
M444_RS30945	COG1404	Belongs to the peptidase S8 family
M444_RS30945	COG4412	M6 family metalloprotease domain protein
M444_RS30945	COG4412	M6 family metalloprotease domain protein
M444_RS30945	COG1404	Belongs to the peptidase S8 family
M444_RS30960	COG2124	cytochrome p450
M444_RS30985	COG3265	gluconokinase activity
M444_RS30995	COG4977	sequence-specific DNA binding
M444_RS31000	COG0346	lactoylglutathione lyase activity
M444_RS31005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M444_RS31055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M444_RS31060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M444_RS31070	COG1132	(ABC) transporter
M444_RS31090	COG2197	response regulator
M444_RS31095	COG4585	Histidine kinase
M444_RS31120	COG0277	FAD linked oxidase domain protein
M444_RS31125	COG2226	methyltransferase
M444_RS31135	COG4264	IucA IucC family
M444_RS31140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M444_RS31150	COG1191	sigma factor activity
M444_RS31155	COG4175	Glycine betaine
M444_RS31155	COG0517	IMP dehydrogenase activity
M444_RS31165	COG2409	Drug exporters of the RND superfamily
M444_RS31170	COG4585	Histidine kinase
M444_RS31175	COG2197	response regulator
M444_RS31205	COG0583	DNA-binding transcription factor activity
M444_RS31210	COG0477	Major facilitator Superfamily
M444_RS31220	COG3226	Transcriptional regulator
M444_RS31280	COG1796	DNA polymerase
M444_RS31280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M444_RS31310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M444_RS31320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M444_RS31325	COG1278	Cold shock
M444_RS31340	COG1846	Transcriptional regulator
M444_RS31345	COG1764	response to oxidative stress
M444_RS31370	COG2197	response regulator
M444_RS31400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M444_RS31405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M444_RS31445	COG2207	Transcriptional regulator
M444_RS31450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M444_RS31455	COG1714	RDD family
M444_RS31550	COG0318	PFAM AMP-dependent synthetase and ligase
M444_RS31590	COG1917	Cupin 2, conserved barrel domain protein
M444_RS31590	COG1396	sequence-specific DNA binding
M444_RS31605	COG2124	cytochrome p450
M444_RS31620	COG3973	AAA domain
M444_RS31640	COG3629	intracellular signal transduction
M444_RS31640	COG3903	Transcriptional regulator
M444_RS31645	COG2197	response regulator
M444_RS31650	COG3903	Transcriptional regulator
M444_RS31650	COG3629	intracellular signal transduction
M444_RS31695	COG4941	Belongs to the sigma-70 factor family
M444_RS31700	COG3795	YCII-related domain
M444_RS31720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M444_RS31730	COG2267	carboxylic ester hydrolase activity
M444_RS31740	COG0671	phosphoesterase, PA-phosphatase related
M444_RS31745	COG2226	methyltransferase
M444_RS31765	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS31790	COG2319	Wd-40 repeat
M444_RS31790	COG4249	Peptidase C14 caspase catalytic subunit p20
M444_RS31805	COG0640	Transcriptional regulator
M444_RS31875	COG4585	Histidine kinase
M444_RS31880	COG2197	response regulator
M444_RS31890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M444_RS31900	COG1960	acyl-CoA dehydrogenase activity
M444_RS31945	COG0477	Major facilitator Superfamily
M444_RS31990	COG1309	transcriptional regulator
M444_RS31995	COG0667	Aldo Keto reductase
M444_RS32090	COG2268	Band 7 protein
M444_RS32125	COG0745	RESPONSE REGULATOR receiver
M444_RS32130	COG5002	protein histidine kinase activity
M444_RS32150	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M444_RS32165	COG3387	PFAM Glycoside hydrolase 15-related
M444_RS32215	COG1191	sigma factor activity
M444_RS32250	COG0714	Associated with various cellular activities
M444_RS32290	COG1278	Cold shock
M444_RS32295	COG0513	Belongs to the DEAD box helicase family
M444_RS32325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M444_RS32355	COG2207	Transcriptional regulator
M444_RS32360	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS32370	COG3631	Ketosteroid isomerase-related protein
M444_RS32375	COG0702	epimerase
M444_RS32385	COG4977	sequence-specific DNA binding
M444_RS32410	COG1196	nuclear chromosome segregation
M444_RS32410	COG0739	heme binding
M444_RS32410	COG0741	lytic transglycosylase activity
M444_RS32440	COG2340	Cysteine-rich secretory protein family
M444_RS32455	COG0667	Aldo Keto reductase
M444_RS32480	COG0456	acetyltransferase
M444_RS32485	COG1024	Enoyl-CoA hydratase
M444_RS32500	COG4977	sequence-specific DNA binding
M444_RS32535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M444_RS32545	COG1051	belongs to the nudix hydrolase family
M444_RS32550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M444_RS32555	COG2814	Major facilitator Superfamily
M444_RS32570	COG1028	Short-chain dehydrogenase reductase Sdr
M444_RS32575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M444_RS32595	COG2124	cytochrome p450
M444_RS32675	COG0784	Response regulator, receiver
M444_RS32680	COG4251	negative regulation of phosphorylation
M444_RS32700	COG0165	Argininosuccinate lyase
M444_RS32710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M444_RS32715	COG3251	PFAM MbtH domain protein
M444_RS32745	COG2423	ornithine cyclodeaminase activity
M444_RS32760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M444_RS32770	COG1846	Transcriptional regulator
M444_RS32840	COG0583	DNA-binding transcription factor activity
M444_RS32845	COG0596	Alpha beta hydrolase
M444_RS32900	COG2890	protein-(glutamine-N5) methyltransferase activity
M444_RS32915	COG0069	glutamate synthase activity
M444_RS32920	COG0028	Belongs to the TPP enzyme family
M444_RS32935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M444_RS32950	COG2326	polyphosphate kinase activity
M444_RS32955	COG1295	ribonuclease BN
M444_RS32995	COG0789	Transcriptional regulator
M444_RS33020	COG0671	phosphoesterase, PA-phosphatase related
M444_RS33050	COG3655	Transcriptional regulator
M444_RS33065	COG4989	oxidoreductase activity
M444_RS33070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M444_RS33085	COG2267	carboxylic ester hydrolase activity
M444_RS33090	COG0583	DNA-binding transcription factor activity
M444_RS33110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M444_RS33115	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M444_RS33115	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M444_RS33190	COG0596	Alpha beta hydrolase
M444_RS33225	COG0586	Pfam SNARE associated Golgi protein
M444_RS33230	COG0671	phosphoesterase, PA-phosphatase related
M444_RS33245	COG0672	)-iron permease
M444_RS33270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M444_RS33310	COG3046	protein related to deoxyribodipyrimidine photolyase
M444_RS33320	COG1733	regulation of RNA biosynthetic process
M444_RS33350	COG1846	Transcriptional regulator
M444_RS33355	COG2409	Drug exporters of the RND superfamily
M444_RS33380	COG0583	DNA-binding transcription factor activity
M444_RS33395	COG0784	Response regulator, receiver
M444_RS33400	COG4251	negative regulation of phosphorylation
M444_RS33410	COG0739	heme binding
M444_RS33445	COG2197	response regulator
M444_RS33520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M444_RS33535	COG0517	IMP dehydrogenase activity
M444_RS33535	COG0516	GMP reductase activity
M444_RS33540	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M444_RS33545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M444_RS33545	COG0574	Belongs to the PEP-utilizing enzyme family
M444_RS33550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M444_RS33575	COG0516	GMP reductase activity
M444_RS33575	COG0517	IMP dehydrogenase activity
M444_RS33645	COG0516	GMP reductase activity
M444_RS33645	COG0517	IMP dehydrogenase activity
M444_RS33650	COG0516	GMP reductase activity
M444_RS33650	COG0517	IMP dehydrogenase activity
M444_RS33660	COG0574	Belongs to the PEP-utilizing enzyme family
M444_RS33660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M444_RS33665	COG1063	alcohol dehydrogenase
M444_RS33685	COG0589	response to stress
M444_RS33700	COG0516	GMP reductase activity
M444_RS33700	COG0517	IMP dehydrogenase activity
M444_RS33705	COG0589	response to stress
M444_RS33715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M444_RS33720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
M444_RS33750	COG2326	polyphosphate kinase activity
M444_RS33765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M444_RS33770	COG0640	Transcriptional regulator
M444_RS33780	COG0640	Transcriptional regulator
M444_RS33790	COG0698	ribose 5-phosphate isomerase
M444_RS33855	COG0596	Alpha beta hydrolase
M444_RS33865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M444_RS33870	COG0765	amino acid transport
M444_RS33880	COG0789	Transcriptional regulator
M444_RS33885	COG2807	transmembrane transport
M444_RS33935	COG1215	transferase activity, transferring glycosyl groups
M444_RS34015	COG2208	phosphoserine phosphatase activity
M444_RS34015	COG2770	Histidine kinase
M444_RS34045	COG2319	Wd-40 repeat
M444_RS34045	COG4249	Peptidase C14 caspase catalytic subunit p20
M444_RS34060	COG0604	alcohol dehydrogenase
M444_RS34080	COG0187	DNA topoisomerase II activity
M444_RS34115	COG2188	Transcriptional regulator
M444_RS34150	COG1595	DNA-templated transcription, initiation
M444_RS34155	COG1595	DNA-templated transcription, initiation
M444_RS34175	COG3293	Transposase
M444_RS34195	COG0583	DNA-binding transcription factor activity
M444_RS34210	COG1309	transcriptional regulator
M444_RS34265	COG1366	Belongs to the anti-sigma-factor antagonist family
M444_RS34290	COG0688	phosphatidylethanolamine metabolic process
M444_RS34300	COG0456	acetyltransferase
M444_RS34315	COG1278	Cold shock
M444_RS34355	COG2814	Major facilitator Superfamily
M444_RS34360	COG2910	NAD(P)H-binding
M444_RS34370	COG1733	regulation of RNA biosynthetic process
M444_RS34420	COG0330	HflC and HflK could
M444_RS34505	COG1857	crispr-associated protein
M444_RS35130	COG0142	geranyltranstransferase activity
M444_RS35890	COG2963	transposase activity
M444_RS36220	COG0753	catalase activity
M444_RS36295	COG1191	sigma factor activity
M444_RS36520	COG0513	Belongs to the DEAD box helicase family
M444_RS36725	COG0574	Belongs to the PEP-utilizing enzyme family
M444_RS36725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M444_RS37285	COG2318	DinB family
M444_RS37305	COG0436	Aminotransferase
M444_RS37555	COG3328	transposase activity
M444_RS38235	COG2423	ornithine cyclodeaminase activity
M444_RS38425	COG0642	Histidine kinase
M444_RS38475	COG2091	lysine biosynthetic process via aminoadipic acid
M444_RS38485	COG0604	alcohol dehydrogenase
M444_RS38485	COG3321	synthase
M444_RS38490	COG0604	alcohol dehydrogenase
M444_RS38490	COG3321	synthase
M444_RS38540	COG1132	(ABC) transporter
M444_RS38545	COG1132	(ABC) transporter
M444_RS38575	COG2304	oxidoreductase activity
M444_RS38610	COG1181	Belongs to the D-alanine--D-alanine ligase family
M444_RS38615	COG3903	Transcriptional regulator
M444_RS38615	COG3629	intracellular signal transduction
M444_RS38670	COG2957	Belongs to the agmatine deiminase family
M444_RS38690	COG3547	Transposase (IS116 IS110 IS902 family)