locus-tag class description HUT08_RS00035 ENOG4105DQ6 Transposase HUT08_RS00040 ENOG4105MP0 transposase HUT08_RS00075 ENOG4105BZ1 (ABC) transporter HUT08_RS00080 ENOG4105BZ1 (ABC) transporter HUT08_RS00105 ENOG4105DXX methyltransferase HUT08_RS00145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS00150 ENOG4107QPD alcohol dehydrogenase HUT08_RS00210 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT08_RS00215 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUT08_RS00460 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HUT08_RS00470 ENOG41082YX Transcriptional regulator, arsr family HUT08_RS00520 ENOG4105EU0 Major facilitator Superfamily HUT08_RS00560 ENOG4105EKQ RNA-directed DNA polymerase HUT08_RS00635 ENOG4108IND Tetr family transcriptional regulator HUT08_RS00665 ENOG4105KVH Transcriptional regulator HUT08_RS00680 ENOG4105CHR reductase HUT08_RS00725 ENOG4108762 serine threonine protein kinase HUT08_RS00735 ENOG4108NNZ chitinase HUT08_RS00745 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUT08_RS00790 ENOG4105CAQ asparagine synthetase HUT08_RS00795 ENOG4105C26 Dehydrogenase HUT08_RS00810 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS00835 ENOG4106JDR secreted HUT08_RS00910 ENOG4105DQE DNA ligase HUT08_RS00915 ENOG4105DQE DNA ligase HUT08_RS00930 ENOG4107R13 MMPL domain protein HUT08_RS00935 ENOG4105CVN desaturase HUT08_RS00950 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) HUT08_RS00960 ENOG4105CTB Polyprenyl synthetase HUT08_RS00975 ENOG4107QQG Dehydrogenase HUT08_RS00990 ENOG4105E4C Lytic transglycosylase catalytic HUT08_RS00995 ENOG4105FQP Beta-lactamase HUT08_RS01045 ENOG4105DQE DNA ligase HUT08_RS01050 ENOG4105DCG PHP domain protein HUT08_RS01055 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT08_RS01060 ENOG4105CPQ Dehydrogenase HUT08_RS01065 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT08_RS01080 ENOG4105E98 transcriptional regulator DeoR family HUT08_RS01100 ENOG4105BZ1 (ABC) transporter HUT08_RS01130 ENOG4105C29 acyl-CoA thioesterase HUT08_RS01140 ENOG4105GWZ Roadblock lc7 family protein HUT08_RS01170 ENOG4105C0D helicase HUT08_RS01180 ENOG4108YYC ycei family HUT08_RS01210 ENOG4105ESN nucleotide-binding protein HUT08_RS01215 ENOG4105ESN nucleotide-binding protein HUT08_RS01220 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HUT08_RS01225 ENOG4105C3U ABC transporter HUT08_RS01230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT08_RS01245 ENOG4105D2B acyl-CoA dehydrogenase HUT08_RS01250 ENOG4105D2B acyl-CoA dehydrogenase HUT08_RS01285 ENOG4105BZU Histidine kinase HUT08_RS01315 ENOG4105CSU acyl-Coa dehydrogenase HUT08_RS01345 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT08_RS01355 ENOG41067HS methyltransferase HUT08_RS01375 ENOG4105WKW Pfam:DUF1458 HUT08_RS01395 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUT08_RS01405 ENOG4105CUB amino acid HUT08_RS01420 ENOG4108JU3 Alkyl hydroperoxide reductase HUT08_RS01430 ENOG4105BZ1 (ABC) transporter HUT08_RS01435 ENOG4108JQ5 ABC transporter HUT08_RS01450 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT08_RS01465 ENOG4107S8C mandelate racemase muconate lactonizing HUT08_RS01470 ENOG410880H cysteine synthase HUT08_RS01525 ENOG41066UM arsR family transcriptional regulator HUT08_RS01545 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT08_RS01550 ENOG4105C5Y PTS System HUT08_RS01555 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT08_RS01580 ENOG4105CTK cobaltochelatase, cobn subunit HUT08_RS01590 ENOG41081F0 Precorrin-8x methylmutase HUT08_RS01605 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HUT08_RS01610 ENOG41061H0 Monooxygenase HUT08_RS01615 ENOG4108K3Z AraC family transcriptional regulator HUT08_RS01630 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUT08_RS01670 ENOG4105F4R Transcriptional regulator mode HUT08_RS01710 ENOG4105CXN decarboxylase HUT08_RS01720 ENOG4107QRI Phosphoketolase HUT08_RS01740 ENOG4108CIP transcriptional regulator HUT08_RS01800 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS01815 ENOG4105VEQ Cold shock protein HUT08_RS01840 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT08_RS01850 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT08_RS01860 ENOG4105F8D glycoside hydrolase family 4 HUT08_RS01900 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HUT08_RS01905 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HUT08_RS01930 ENOG4108IG5 Transcriptional regulator HUT08_RS01945 ENOG4105D44 asparaginase HUT08_RS01950 ENOG4108VQR secreted hydrolase HUT08_RS01965 ENOG4105S7M extracellular small neutral protease HUT08_RS01970 ENOG4105EU0 Major facilitator Superfamily HUT08_RS01975 ENOG4105R1U AraC Family Transcriptional Regulator HUT08_RS01980 ENOG410847I Transcriptional regulator, BadM Rrf2 family HUT08_RS01985 ENOG4105C1J atp-dependent rna helicase HUT08_RS01990 ENOG4105VEQ Cold shock protein HUT08_RS02000 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HUT08_RS02010 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT08_RS02020 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT08_RS02025 ENOG4105K4I Scp-like extracellular HUT08_RS02055 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS02095 ENOG4108HMN Caspase domain HUT08_RS02105 ENOG4105BZU Histidine kinase HUT08_RS02120 ENOG4107RCI amp-dependent synthetase and ligase HUT08_RS02155 ENOG4105BZU Histidine kinase HUT08_RS02160 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS02195 ENOG4108X07 Tetr family transcriptional regulator HUT08_RS02220 ENOG4105YVS arsR family transcriptional regulator HUT08_RS02225 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT08_RS02230 ENOG4105DVM PP-loop domain protein HUT08_RS02235 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase HUT08_RS02240 ENOG4105C8M UPF0272 protein HUT08_RS02260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT08_RS02265 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT08_RS02285 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUT08_RS02290 ENOG4105GRZ Ycii-related protein HUT08_RS02310 ENOG4108YXU transcriptional regulator AsnC family HUT08_RS02315 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT08_RS02350 ENOG4107Y2X deaminase HUT08_RS02365 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT08_RS02370 ENOG4105CHP RNA polymerase HUT08_RS02375 ENOG4105GRZ Ycii-related protein HUT08_RS02385 ENOG4105EEM helicase HUT08_RS02400 ENOG4108V06 Glutathione peroxidase HUT08_RS02405 ENOG4105F9F transposase HUT08_RS02425 ENOG4107R37 Glutamate dehydrogenase HUT08_RS02440 ENOG4108V1U phospholipid-binding protein HUT08_RS02450 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT08_RS02460 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT08_RS02470 ENOG4108373 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS02475 ENOG4105D65 subunit l HUT08_RS02480 ENOG4105C8S subunit m HUT08_RS02485 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS02490 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT08_RS02500 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT08_RS02515 ENOG4107SM8 Adenylate Guanylate cyclase HUT08_RS02520 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT08_RS02550 ENOG4105F1A Pyruvate formate-lyase HUT08_RS02565 ENOG4105C5I Dehydrogenase HUT08_RS02575 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUT08_RS02585 ENOG4105DBV ornithine carbamoyltransferase HUT08_RS02595 ENOG4105CSX c4-dicarboxylate anaerobic carrier HUT08_RS02605 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT08_RS02610 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT08_RS02620 ENOG4105C2X Arabinose 5-phosphate isomerase HUT08_RS02630 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUT08_RS02655 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT08_RS02670 ENOG4105CD5 CoA-binding domain protein HUT08_RS02675 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUT08_RS02690 ENOG4108IUE nitrate reductase beta subunit HUT08_RS02695 ENOG4105R3A Nitrate reductase HUT08_RS02705 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT08_RS02715 ENOG4107QRI Phosphoketolase HUT08_RS02750 ENOG4105C0A alcohol dehydrogenase HUT08_RS02770 ENOG4107ZED Uncharacterised protein family UPF0047 HUT08_RS02775 ENOG4107S2Z UPF0761 membrane protein HUT08_RS02795 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT08_RS02800 ENOG4105E2Y ABC, transporter HUT08_RS02815 ENOG4105H3G oxidoreductase HUT08_RS02820 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT08_RS02825 ENOG4107QR9 Iron-sulfur cluster binding protein HUT08_RS02830 ENOG41080R8 Conserved Protein HUT08_RS02835 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT08_RS02840 ENOG4105JXB ankyrin repeat-containing protein HUT08_RS02855 ENOG41073TP transcriptional regulator HUT08_RS02865 ENOG4105Q70 HUT08_RS02875 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT08_RS02895 ENOG4105EW9 transcriptional regulator AsnC family HUT08_RS02910 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS02920 ENOG41060BG Tetr family transcriptional regulator HUT08_RS02980 ENOG4107RR1 TRANSCRIPTIONal HUT08_RS02985 ENOG4105C26 Dehydrogenase HUT08_RS03020 ENOG4105BZU Histidine kinase HUT08_RS03025 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS03190 ENOG4105CAQ asparagine synthetase HUT08_RS03195 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT08_RS03210 ENOG4105BZU Histidine kinase HUT08_RS03235 ENOG4105DXX methyltransferase HUT08_RS03240 ENOG4105ECP epimerase HUT08_RS03245 ENOG4105C0A alcohol dehydrogenase HUT08_RS03250 ENOG4107URF beta-phospho-glucomutase HUT08_RS03255 ENOG4105D3W isochorismatase HUT08_RS03275 ENOG4105EMN RNA polymerase sigma factor HUT08_RS03280 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT08_RS03295 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT08_RS03350 ENOG4105CN1 protease HUT08_RS03360 ENOG4105CHR reductase HUT08_RS03365 ENOG41062T2 Acyl carrier protein HUT08_RS03370 ENOG4108KQ6 Enoyl-CoA hydratase HUT08_RS03375 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HUT08_RS03380 ENOG4108JA1 polyketide synthase HUT08_RS03385 ENOG4107SQU synthase HUT08_RS03390 ENOG4105C0W non-ribosomal peptide synthetase HUT08_RS03395 ENOG4107SQU synthase HUT08_RS03395 ENOG4107SQU synthase HUT08_RS03400 ENOG4107SQU synthase HUT08_RS03405 ENOG4105C0W non-ribosomal peptide synthetase HUT08_RS03415 ENOG4108MGH Enoyl-CoA hydratase HUT08_RS03420 ENOG4107QKG PfaD family HUT08_RS03425 ENOG4108JA1 polyketide synthase HUT08_RS03430 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT08_RS03445 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT08_RS03480 ENOG4108Z4X TRANSCRIPTIONal HUT08_RS03495 ENOG4108R86 Transcriptional regulator HUT08_RS03500 ENOG4105BZU Histidine kinase HUT08_RS03505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT08_RS03515 ENOG4105CJ1 ABC, transporter HUT08_RS03555 ENOG4105CKK Glycosyl transferase, family 2 HUT08_RS03575 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS03595 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT08_RS03600 ENOG4105ES4 Nitrilase HUT08_RS03605 ENOG4108RVA ribokinase HUT08_RS03610 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT08_RS03640 ENOG4107SQU synthase HUT08_RS03670 ENOG41062D9 Histidine kinase HUT08_RS03675 ENOG4108KXV response regulator HUT08_RS03685 ENOG4105CSH Transporter HUT08_RS03705 ENOG4107TPY serine threonine protein kinase HUT08_RS03715 ENOG4105M4P Tetr family transcriptional regulator HUT08_RS03735 ENOG4105CHH sulfate transporter HUT08_RS03765 ENOG4105D9P serine threonine protein kinase HUT08_RS03785 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HUT08_RS03930 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS03940 ENOG4108Z4X TRANSCRIPTIONal HUT08_RS03960 ENOG4106UDK Cellulose-binding, family II HUT08_RS03965 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT08_RS03985 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT08_RS03995 ENOG4108VW9 Membrane HUT08_RS04000 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS04030 ENOG4105C2M dna polymerase I HUT08_RS04170 ENOG4108FKH Transglycosylase SLT domain HUT08_RS04245 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT08_RS04320 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS04355 ENOG4105D4P Coproporphyrinogen iii oxidase HUT08_RS04385 ENOG41090WU lipolytic protein G-D-S-L family HUT08_RS04410 ENOG4105EWU Squalene--hopene cyclase HUT08_RS04420 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT08_RS04430 ENOG4105FBD synthase HUT08_RS04440 ENOG4105EY8 ABC transporter HUT08_RS04485 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT08_RS04495 ENOG4105E39 Enoyl-CoA hydratase HUT08_RS04505 ENOG4105BZM domain protein HUT08_RS04520 ENOG4105C5H ABC transporter HUT08_RS04530 ENOG4105C5H ABC transporter HUT08_RS04550 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUT08_RS04555 ENOG4105C94 Transporter HUT08_RS04610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT08_RS04615 ENOG4105CHU acetyl-coa acetyltransferase HUT08_RS04625 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT08_RS04645 ENOG4105JHE Major Facilitator Superfamily HUT08_RS04650 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT08_RS04655 ENOG4105EG6 Saccharopine dehydrogenase HUT08_RS04670 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT08_RS04690 ENOG4105KF0 sporulation and cell division protein, SsgA HUT08_RS04700 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) HUT08_RS04710 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT08_RS04720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT08_RS04725 ENOG4108JQ6 ABC transporter HUT08_RS04745 ENOG4105BZU Histidine kinase HUT08_RS04750 ENOG4105YVM Phosphoesterase, PA-phosphatase related HUT08_RS04775 ENOG41082YX Transcriptional regulator, arsr family HUT08_RS04790 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HUT08_RS04795 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HUT08_RS04800 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT08_RS04805 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT08_RS04810 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT08_RS04825 ENOG4105CDA abc transporter atp-binding protein HUT08_RS04830 ENOG4105EAB amino acid AbC transporter HUT08_RS04845 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT08_RS04850 ENOG4108KPJ rna polymerase sigma factor HUT08_RS04875 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT08_RS04880 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT08_RS04915 ENOG4105FDR Membrane HUT08_RS04920 ENOG4105EW9 transcriptional regulator AsnC family HUT08_RS04955 ENOG4108N23 SpoOM-related protein HUT08_RS04965 ENOG4105ENX hydrolase HUT08_RS05080 ENOG4105DGI Alkaline phosphatase HUT08_RS05090 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT08_RS05115 ENOG4107RRD Dehydrogenase HUT08_RS05145 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HUT08_RS05160 ENOG4105EQQ protein containing aminopeptidase domain HUT08_RS05185 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT08_RS05195 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS05215 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT08_RS05230 ENOG4105CN5 Metallo-Beta-Lactamase HUT08_RS05270 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT08_RS05300 ENOG4105DHU Bile acid HUT08_RS05305 ENOG4107653 Transcriptional regulator HUT08_RS05335 ENOG4105CV8 reductase HUT08_RS05345 ENOG4108KXM LysR family Transcriptional regulator HUT08_RS05355 ENOG4106T9R serine protease HUT08_RS05375 ENOG4105EMN RNA polymerase sigma factor HUT08_RS05385 ENOG4105VBF alkaline shock protein HUT08_RS05390 ENOG410842T Pterin carbinolamine dehydratase HUT08_RS05415 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT08_RS05420 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUT08_RS05445 ENOG4105EYF MMPL domain protein HUT08_RS05450 ENOG4105BZU Histidine kinase HUT08_RS05480 ENOG4105TCD Broad-specificity glycosaminoglycan lyase (By similarity) HUT08_RS05500 ENOG4105M4P Tetr family transcriptional regulator HUT08_RS05505 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT08_RS05520 ENOG4105D5Q Arginine ornithine antiporter HUT08_RS05535 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT08_RS05605 ENOG4108Z0Z intracellular protease Pfpi family HUT08_RS05615 ENOG41080XP Cbs domain HUT08_RS05640 ENOG4108IXY short-chain dehydrogenase reductase HUT08_RS05655 ENOG4105E93 esterase HUT08_RS05710 ENOG4107RTG Major Facilitator superfamily HUT08_RS05735 ENOG4107R6F Alpha Beta Hydrolase Fold protein HUT08_RS05770 ENOG4107TXC Transcriptional regulator HUT08_RS05780 ENOG4108KPJ rna polymerase sigma factor HUT08_RS05810 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS05810 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS05815 ENOG4105WQI isochorismatase HUT08_RS05820 ENOG4105WQI isochorismatase HUT08_RS05825 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT08_RS05830 ENOG4105E4F Isochorismate synthase HUT08_RS05835 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT08_RS05840 ENOG4108MES Periplasmic binding protein HUT08_RS05845 ENOG4105DQ5 transport system permease protein HUT08_RS05850 ENOG4105TVJ transport system, permease HUT08_RS05855 ENOG4105E0A ABC, transporter HUT08_RS05860 ENOG4105CZN Potassium uptake protein HUT08_RS05865 ENOG4107ZYR domain protein HUT08_RS05875 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT08_RS05880 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT08_RS05885 ENOG4107R13 MMPL domain protein HUT08_RS05915 ENOG4105KME endoribonuclease L-psp HUT08_RS05935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT08_RS05955 ENOG4106NMR serine protease HUT08_RS05985 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT08_RS05990 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS05995 ENOG4105C57 major facilitator superfamily HUT08_RS06000 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT08_RS06010 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT08_RS06030 ENOG4108I69 Glycosyl transferases group 1 HUT08_RS06045 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT08_RS06050 ENOG4105F6E Acyl-transferase HUT08_RS06055 ENOG4105CAT Cytidine monophosphate kinase HUT08_RS06075 ENOG4105FE9 pseudouridine synthase HUT08_RS06080 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT08_RS06085 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUT08_RS06100 ENOG4105DCF alanine dehydrogenase HUT08_RS06110 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT08_RS06125 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT08_RS06135 ENOG4108YZ4 nudix hydrolase HUT08_RS06140 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT08_RS06145 ENOG4105BZP glycoside hydrolase 15-related HUT08_RS06160 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT08_RS06165 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT08_RS06180 ENOG4105E0A ABC, transporter HUT08_RS06185 ENOG4105TVJ transport system, permease HUT08_RS06190 ENOG4105DQ5 transport system permease protein HUT08_RS06205 ENOG4105DSU hydrolase HUT08_RS06260 ENOG4108VX5 3-methyladenine DNA glycosylase HUT08_RS06275 ENOG4108V1U phospholipid-binding protein HUT08_RS06295 ENOG4105DKW ABC transporter HUT08_RS06300 ENOG4108UF8 HUT08_RS06310 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS06330 ENOG4105IDI abc transporter atp-binding protein HUT08_RS06335 ENOG4105EAC phosphoserine phosphatase HUT08_RS06350 ENOG4105DJ2 Major Facilitator Superfamily HUT08_RS06355 ENOG4107YCY Transcriptional regulator HUT08_RS06365 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT08_RS06370 ENOG4105CHR reductase HUT08_RS06385 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT08_RS06405 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT08_RS06410 ENOG4107QN1 sodium solute HUT08_RS06435 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT08_RS06445 ENOG4105BZP glycoside hydrolase 15-related HUT08_RS06475 ENOG4105VBF alkaline shock protein HUT08_RS06485 ENOG4106YT9 Enoyl-CoA hydratase HUT08_RS06495 ENOG4105C5H ABC transporter HUT08_RS06525 ENOG4105CR5 Class II aldolase adducin family protein HUT08_RS06540 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT08_RS06560 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT08_RS06595 ENOG4108JPW Aminotransferase HUT08_RS06600 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HUT08_RS06605 ENOG4105EV8 ectoine hydroxylase HUT08_RS06610 ENOG4105C3J Cysteine desulfurase HUT08_RS06620 ENOG4108JGH Tetr family transcriptional regulator HUT08_RS06645 ENOG4105DEN Luciferase family HUT08_RS06665 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HUT08_RS06670 ENOG4108RFG Tetr family transcriptional regulator HUT08_RS06675 ENOG410814C multidrug resistance protein HUT08_RS06685 ENOG4105CEP NADH dehydrogenase HUT08_RS06700 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT08_RS06705 ENOG4105C9B Cysteine desulfurase HUT08_RS06710 ENOG4105C3K feS assembly ATPase SufC HUT08_RS06735 ENOG4105CJ1 ABC, transporter HUT08_RS06745 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HUT08_RS06760 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT08_RS06770 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT08_RS06785 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT08_RS06790 ENOG4107QP8 phosphohexose isomerase HUT08_RS06805 ENOG4105CP7 Triose-phosphate isomerase HUT08_RS06810 ENOG4105BZA Phosphoglycerate kinase HUT08_RS06815 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT08_RS06820 ENOG4105CIE May be required for sporulation (By similarity) HUT08_RS06825 ENOG4105CHW UPF0052 protein HUT08_RS06830 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT08_RS06835 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT08_RS06875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT08_RS06905 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUT08_RS06920 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT08_RS06925 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT08_RS06960 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT08_RS06980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS07005 ENOG4105KA0 thioesterase Superfamily protein HUT08_RS07030 ENOG4105CGH 5'-nucleotidase HUT08_RS07065 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HUT08_RS07085 ENOG4105CIR epoxide hydrolase HUT08_RS07095 ENOG4105ESP cell wall surface anchor family protein HUT08_RS07105 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT08_RS07140 ENOG410832A alpha/beta hydrolase fold HUT08_RS07155 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT08_RS07160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS07185 ENOG4105CBC glutamate synthase HUT08_RS07195 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT08_RS07215 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT08_RS07220 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT08_RS07230 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT08_RS07260 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT08_RS07285 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT08_RS07290 ENOG4108176 endoribonuclease L-psp HUT08_RS07295 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT08_RS07300 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT08_RS07310 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT08_RS07315 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT08_RS07320 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT08_RS07330 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT08_RS07335 ENOG4108Z66 YbaK ebsC protein HUT08_RS07365 ENOG4105C0B DNA polymerase III (alpha subunit) HUT08_RS07415 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT08_RS07425 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT08_RS07430 ENOG4107VQS DivIVA family HUT08_RS07440 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT08_RS07445 ENOG4105DFA alanine racemase domain protein HUT08_RS07450 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUT08_RS07455 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT08_RS07460 ENOG4105ME9 cell division protein FtsQ HUT08_RS07465 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT08_RS07475 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT08_RS07480 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT08_RS07485 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HUT08_RS07490 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT08_RS07495 ENOG4105CJN penicillin-binding protein HUT08_RS07505 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT08_RS07515 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT08_RS07535 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT08_RS07545 ENOG4105C2J ABC transporter HUT08_RS07550 ENOG4105ECB domain protein HUT08_RS07555 ENOG4107Z3H Transcriptional regulator, TetR family HUT08_RS07560 ENOG4105EWK phytoene HUT08_RS07575 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT08_RS07600 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT08_RS07610 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT08_RS07620 ENOG4108UQY Iron-storage protein HUT08_RS07630 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT08_RS07640 ENOG4105CTQ phosphohexokinase HUT08_RS07645 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS07650 ENOG4105ENE Histidine kinase HUT08_RS07675 ENOG4105DKQ ROK family HUT08_RS07685 ENOG4105D0U Arsenite-activated ATPase (ArsA) HUT08_RS07720 ENOG4105K4H Nlp p60 protein HUT08_RS07750 ENOG4106F60 Histidine kinase HUT08_RS07755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT08_RS07765 ENOG4105BZW Glycerate kinase HUT08_RS07770 ENOG4105C9B Cysteine desulfurase HUT08_RS07775 ENOG4108I0Q anthranilate phosphoribosyltransferase HUT08_RS07780 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT08_RS07785 ENOG4107EUI c reductase, iron-sulfur HUT08_RS07790 ENOG4107UDY cytochrome C HUT08_RS07795 ENOG4105CCU oxidase (Subunit III) HUT08_RS07805 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT08_RS07810 ENOG4105MCD Part of cytochrome c oxidase, its function is HUT08_RS07815 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT08_RS07820 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT08_RS07830 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HUT08_RS07835 ENOG4107T4Z adenosine kinase HUT08_RS07855 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT08_RS07860 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS07865 ENOG4105BZU Histidine kinase HUT08_RS07885 ENOG4105DXX methyltransferase HUT08_RS07895 ENOG4105C0H protease HUT08_RS07905 ENOG4108YZT Adenosylcobinamide kinase HUT08_RS07910 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT08_RS07915 ENOG4105CRK lysyL-tRNA synthetase HUT08_RS07935 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT08_RS07955 ENOG4105BZU Histidine kinase HUT08_RS07960 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS07965 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT08_RS07990 ENOG4105ECP epimerase HUT08_RS08005 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT08_RS08010 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT08_RS08085 ENOG4107ZVI PhiRv2 prophage protein HUT08_RS08100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT08_RS08125 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HUT08_RS08145 ENOG4108222 arsenate reductase HUT08_RS08155 ENOG4105E0A ABC, transporter HUT08_RS08160 ENOG4105EHG Permease protein HUT08_RS08170 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS08175 ENOG4105WQI isochorismatase HUT08_RS08195 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT08_RS08225 ENOG4107NHD transcriptional regulator HUT08_RS08245 ENOG4105DR9 pseudouridine synthase HUT08_RS08250 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS08275 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT08_RS08290 ENOG4105CG3 alpha amylase, catalytic region HUT08_RS08295 ENOG4105ETE Transcriptional regulator (LacI family HUT08_RS08305 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT08_RS08310 ENOG4105ED2 Beta-lactamase HUT08_RS08315 ENOG4105C5F glutamine synthetase HUT08_RS08320 ENOG4107MM9 BNR Asp-box repeat-containing protein HUT08_RS08325 ENOG4108WYP Transcriptional regulator HUT08_RS08335 ENOG4107R16 Multicopper oxidase HUT08_RS08350 ENOG4105C4K Nad synthetase HUT08_RS08395 ENOG4107ZXU DSBA oxidoreductase HUT08_RS08405 ENOG4108JGH Tetr family transcriptional regulator HUT08_RS08410 ENOG4105C57 major facilitator superfamily HUT08_RS08415 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT08_RS08420 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS08440 ENOG4107XZ0 Peptidase M50 HUT08_RS08470 ENOG4108478 ec 3.2.1.18 HUT08_RS08525 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT08_RS08530 ENOG4105EHG Permease protein HUT08_RS08535 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT08_RS08540 ENOG4106A0S HUT08_RS08550 ENOG4105YIP Tetr family transcriptional regulator HUT08_RS08560 ENOG4105CIK Amidinotransferase HUT08_RS08575 ENOG4105C2C drug resistance transporter, Bcr CflA HUT08_RS08585 ENOG4105DGI Alkaline phosphatase HUT08_RS08590 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT08_RS08595 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HUT08_RS08625 ENOG4105EYF MMPL domain protein HUT08_RS08660 ENOG4105D7T ABC transporter HUT08_RS08665 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT08_RS08675 ENOG4107XFJ UPF0246 protein HUT08_RS08680 ENOG4108UHU Aldolase HUT08_RS08695 ENOG4105EGD dinuclear metal center protein, YbgI family HUT08_RS08700 ENOG4108MES Periplasmic binding protein HUT08_RS08710 ENOG4108M15 ABC transporter HUT08_RS08720 ENOG4105BZU Histidine kinase HUT08_RS08745 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT08_RS08750 ENOG4108S01 response regulator HUT08_RS08790 ENOG4107QVI Methyltransferase, type 11 HUT08_RS08795 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT08_RS08800 ENOG4108SGK Tetr family transcriptional regulator HUT08_RS08830 ENOG4108JJB ABC transporter HUT08_RS08845 ENOG4105F2C Acetyl-CoA acetyltransferase HUT08_RS08870 ENOG4105EYF MMPL domain protein HUT08_RS08955 ENOG4105MGM doxx family HUT08_RS08965 ENOG4105E4C Lytic transglycosylase catalytic HUT08_RS08990 ENOG4108KXM LysR family Transcriptional regulator HUT08_RS09015 ENOG4105FDP GntR family transcriptional regulator HUT08_RS09025 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS09040 ENOG4107T5V SNARE associated Golgi HUT08_RS09050 ENOG4105DAX Pfam:DUF2983 HUT08_RS09095 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT08_RS09125 ENOG4108ZGX Histidine kinase HUT08_RS09130 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS09145 ENOG4105CPC Aldo Keto reductase HUT08_RS09150 ENOG4105VUF Transcriptional regulator HUT08_RS09155 ENOG4107S1E Beta-lactamase HUT08_RS09175 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT08_RS09180 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT08_RS09185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT08_RS09205 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT08_RS09210 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT08_RS09220 ENOG4105MC2 DSBA oxidoreductase HUT08_RS09225 ENOG4105DY8 decarboxylase HUT08_RS09230 ENOG4105CFH Aspartokinase HUT08_RS09245 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT08_RS09250 ENOG4107RSM transcriptional regulator HUT08_RS09255 ENOG4105EW9 transcriptional regulator AsnC family HUT08_RS09280 ENOG4105D7W serine acetyltransferase HUT08_RS09285 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT08_RS09295 ENOG4108JPW Aminotransferase HUT08_RS09310 ENOG4105DYW oxidoreductase HUT08_RS09315 ENOG4105J7D transcriptional regulator HUT08_RS09325 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT08_RS09330 ENOG41080RH Thioredoxin HUT08_RS09335 ENOG4108KXM LysR family Transcriptional regulator HUT08_RS09345 ENOG410900P UPF0336 protein HUT08_RS09355 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT08_RS09380 ENOG4107R13 MMPL domain protein HUT08_RS09390 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT08_RS09405 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT08_RS09430 ENOG4107S9F NmrA family HUT08_RS09490 ENOG4105KRQ Addiction module toxin, Txe YoeB family HUT08_RS09525 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUT08_RS09530 ENOG4105MA6 gCN5-related N-acetyltransferase HUT08_RS09535 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HUT08_RS09540 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT08_RS09560 ENOG4108531 cuta1 divalent ion tolerance protein HUT08_RS09590 ENOG4107S9F NmrA family HUT08_RS09675 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT08_RS09695 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT08_RS09700 ENOG4105DSE periplasmic solute binding protein HUT08_RS09705 ENOG4105FDK ABC transporter HUT08_RS09710 ENOG4105FAV ABC, transporter HUT08_RS09725 ENOG4105JXH GntR family transcriptional regulator HUT08_RS09730 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT08_RS09735 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT08_RS09755 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS09760 ENOG4105BZU Histidine kinase HUT08_RS09765 ENOG4105EYF MMPL domain protein HUT08_RS09775 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT08_RS09780 ENOG4105D4Y metalloprotease HUT08_RS09795 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT08_RS09820 ENOG4107SM8 Adenylate Guanylate cyclase HUT08_RS09830 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT08_RS09840 ENOG4107T4Z adenosine kinase HUT08_RS09855 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT08_RS09860 ENOG4107YU2 histidine triad (hIT) protein HUT08_RS09875 ENOG4107QWG 2-Nitropropane dioxygenase HUT08_RS09880 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT08_RS09885 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT08_RS09915 ENOG4108IQE Amp-dependent synthetase and ligase HUT08_RS09920 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT08_RS09925 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT08_RS09960 ENOG4105CVA phosphate HUT08_RS10035 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HUT08_RS10045 ENOG4105EPR degv family HUT08_RS10055 ENOG4105C8T Leucyl-tRNA synthetase HUT08_RS10065 ENOG41065SU Two-component system sensor kinase HUT08_RS10070 ENOG4108KXV response regulator HUT08_RS10080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT08_RS10085 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT08_RS10110 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT08_RS10125 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT08_RS10140 ENOG4105D0M Protease HtpX homolog HUT08_RS10155 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT08_RS10165 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT08_RS10175 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT08_RS10180 ENOG4105K46 50S ribosomal protein l27 HUT08_RS10185 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT08_RS10190 ENOG4105C03 ribonuclease HUT08_RS10200 ENOG4108762 serine threonine protein kinase HUT08_RS10230 ENOG4105CNI cell division protein FtsW HUT08_RS10235 ENOG4105CJN penicillin-binding protein HUT08_RS10250 ENOG4105DFF Rod shape-determining protein mreb HUT08_RS10255 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT08_RS10265 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT08_RS10270 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT08_RS10285 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT08_RS10290 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT08_RS10295 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT08_RS10300 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT08_RS10335 ENOG4105C19 ABC transporter HUT08_RS10340 ENOG4107S91 Sodium hydrogen exchanger HUT08_RS10360 ENOG4105C85 amino acid HUT08_RS10365 ENOG4105VKD bioY protein HUT08_RS10370 ENOG4105C85 amino acid HUT08_RS10375 ENOG4105C85 amino acid HUT08_RS10380 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUT08_RS10410 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS10455 ENOG4105D8X mechanosensitive ion channel HUT08_RS10460 ENOG4105E2R ROK family HUT08_RS10475 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT08_RS10480 ENOG4105F8D glycoside hydrolase family 4 HUT08_RS10510 ENOG4105CT1 (ABC) transporter HUT08_RS10555 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT08_RS10585 ENOG4105VHU single-stranded DNA-binding protein HUT08_RS10590 ENOG4105C57 major facilitator superfamily HUT08_RS10625 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HUT08_RS10640 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS10645 ENOG4107RDP Dehydrogenase HUT08_RS10650 ENOG4107RA9 decarboxylase HUT08_RS10695 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) HUT08_RS10715 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS10725 ENOG4105DBV ornithine carbamoyltransferase HUT08_RS10795 ENOG4105EMU Dehydrogenase HUT08_RS10865 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS10890 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HUT08_RS10900 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HUT08_RS10915 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS10920 ENOG4105BZU Histidine kinase HUT08_RS10940 ENOG4108IUE nitrate reductase beta subunit HUT08_RS10945 ENOG4105R3A Nitrate reductase HUT08_RS10955 ENOG4105MKU Transcriptional regulator HUT08_RS10960 ENOG4105KME endoribonuclease L-psp HUT08_RS10965 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT08_RS10980 ENOG41082SX arsR family transcriptional regulator HUT08_RS11000 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT08_RS11035 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS11040 ENOG4107SM8 Adenylate Guanylate cyclase HUT08_RS11050 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT08_RS11060 ENOG4105DND Transcriptional regulator HUT08_RS11075 ENOG4105E33 succinate dehydrogenase HUT08_RS11160 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HUT08_RS11185 ENOG4105C26 Dehydrogenase HUT08_RS11190 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUT08_RS11195 ENOG4105DH8 myo-inositol catabolism HUT08_RS11205 ENOG4105D7K pfkb domain protein HUT08_RS11215 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT08_RS11220 ENOG4106448 streptomycin biosynthesis protein strI HUT08_RS11255 ENOG41060NJ transcriptional regulator HUT08_RS11265 ENOG4108594 Permease of the drug metabolite transporter HUT08_RS11270 ENOG4105EGI Transcriptional regulator HUT08_RS11320 ENOG4108XFF HUT08_RS11325 ENOG4105C29 acyl-CoA thioesterase HUT08_RS11340 ENOG4107QX3 carboxylase HUT08_RS11350 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT08_RS11355 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS11370 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT08_RS11380 ENOG4105ECQ AraC Family Transcriptional Regulator HUT08_RS11385 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUT08_RS11400 ENOG4105ETE Transcriptional regulator (LacI family HUT08_RS11415 ENOG4105E7U AraC family transcriptional regulator HUT08_RS11435 ENOG4108ZM9 phosphoglycerate mutase HUT08_RS11460 ENOG4105CHR reductase HUT08_RS11500 ENOG4105DEN Luciferase family HUT08_RS11520 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT08_RS11560 ENOG4108M1A Chitin-binding protein HUT08_RS11590 ENOG4105JXH GntR family transcriptional regulator HUT08_RS11595 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT08_RS11610 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS11630 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HUT08_RS11635 ENOG4108MP3 ABC transporter, permease HUT08_RS11655 ENOG4105FDP GntR family transcriptional regulator HUT08_RS11675 ENOG4105D9R oxidoreductase HUT08_RS11680 ENOG4105E1V na solute symporter HUT08_RS11700 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT08_RS11730 ENOG4106BRA Membrane HUT08_RS11745 ENOG4108IUW ABC transporter HUT08_RS11760 ENOG4105BZ4 penicillin-binding protein HUT08_RS11770 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT08_RS11800 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT08_RS11810 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT08_RS11830 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT08_RS11860 ENOG4105C85 amino acid HUT08_RS11870 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT08_RS11880 ENOG4108RWI nicotinamidase HUT08_RS11920 ENOG4105KF0 sporulation and cell division protein, SsgA HUT08_RS11935 ENOG4105CQB FAD linked oxidase domain protein HUT08_RS11945 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT08_RS11955 ENOG4105E90 ABC transporter HUT08_RS11960 ENOG4108IJ8 ABC transporter HUT08_RS11965 ENOG4105E90 ABC transporter HUT08_RS11980 ENOG41063PX domain protein HUT08_RS11995 ENOG41086VY Fic/DOC family HUT08_RS12005 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT08_RS12010 ENOG4107ZR7 Membrane HUT08_RS12020 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS12055 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS12055 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS12070 ENOG410630P Transcriptional regulator HUT08_RS12075 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT08_RS12115 ENOG4105F27 Major Facilitator HUT08_RS12120 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS12130 ENOG4108UJU UPF0301 protein HUT08_RS12135 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT08_RS12140 ENOG4108426 dNA-binding protein HUT08_RS12150 ENOG4105EEM helicase HUT08_RS12150 ENOG4105EEM helicase HUT08_RS12175 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT08_RS12180 ENOG4105CN1 protease HUT08_RS12195 ENOG4105CAK Cell division ATP-binding protein ftsE HUT08_RS12210 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT08_RS12215 ENOG4108QVN serine threonine protein kinase HUT08_RS12220 ENOG4108UGD Serine Threonine protein kinase HUT08_RS12240 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT08_RS12240 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT08_RS12250 ENOG4108KPJ rna polymerase sigma factor HUT08_RS12255 ENOG4105C7I Dehydrogenase HUT08_RS12280 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT08_RS12285 ENOG4105D9U N-acetyltransferase HUT08_RS12290 ENOG4105T0Z Conserved Protein HUT08_RS12295 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS12300 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT08_RS12310 ENOG4105G3P Lipoprotein lpqB HUT08_RS12315 ENOG4105BZU Histidine kinase HUT08_RS12320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT08_RS12325 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT08_RS12350 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT08_RS12355 ENOG4105DM4 PTS System HUT08_RS12365 ENOG4105EIP mannose-6-phosphate isomerase HUT08_RS12375 ENOG4105W49 UPF0434 protein HUT08_RS12380 ENOG4107QKV phosphomannomutase HUT08_RS12385 ENOG4105DAA L-lactate HUT08_RS12410 ENOG4107RGC Glycosyl transferase, family 2 HUT08_RS12415 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT08_RS12430 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT08_RS12440 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT08_RS12455 ENOG4108KGH TRANSCRIPTIONal HUT08_RS12460 ENOG4107TB5 TRANSCRIPTIONal HUT08_RS12480 ENOG4108KGH TRANSCRIPTIONal HUT08_RS12495 ENOG4108KGH TRANSCRIPTIONal HUT08_RS12515 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT08_RS12520 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS12535 ENOG4105CJ1 ABC, transporter HUT08_RS12590 ENOG41065SU Two-component system sensor kinase HUT08_RS12595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT08_RS12600 ENOG4105DUX Transporter HUT08_RS12610 ENOG41082AN stage II sporulation protein HUT08_RS12615 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT08_RS12620 ENOG41067SE Tetr family transcriptional regulator HUT08_RS12645 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT08_RS12660 ENOG4105CGP Urocanate hydratase HUT08_RS12665 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT08_RS12670 ENOG4105WPR Transcriptional regulator, ARAC family HUT08_RS12675 ENOG4105C2C drug resistance transporter, Bcr CflA HUT08_RS12680 ENOG4105CTU Proline racemase HUT08_RS12695 ENOG41065RR hydrogen cyanide synthase HcnA HUT08_RS12755 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS12795 ENOG4105CHU acetyl-coa acetyltransferase HUT08_RS12820 ENOG4105EBR Carboxylesterase HUT08_RS12835 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS12850 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT08_RS12855 ENOG4107RBB ABC transporter, permease HUT08_RS12860 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT08_RS12905 ENOG4105ECQ AraC Family Transcriptional Regulator HUT08_RS12930 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT08_RS12945 ENOG4106A3M Cytochrome p-450 HUT08_RS13005 ENOG4105C84 Histidine ammonia-lyase HUT08_RS13015 ENOG4105KDM Diguanylate cyclase with gaf sensor HUT08_RS13020 ENOG4105E39 Enoyl-CoA hydratase HUT08_RS13025 ENOG4108QER Adenylate cyclase HUT08_RS13035 ENOG4105D8K carboxyl transferase HUT08_RS13045 ENOG4107WR6 Maf-like protein HUT08_RS13055 ENOG4108JIK carboxylase HUT08_RS13085 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT08_RS13100 ENOG4105C26 Dehydrogenase HUT08_RS13105 ENOG4105C26 Dehydrogenase HUT08_RS13115 ENOG4105NAF rna polymerase sigma factor HUT08_RS13120 ENOG4108KXV response regulator HUT08_RS13125 ENOG41065SU Two-component system sensor kinase HUT08_RS13150 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT08_RS13165 ENOG4107RSM transcriptional regulator HUT08_RS13170 ENOG4105D94 Major Facilitator Superfamily HUT08_RS13195 ENOG4105UIB (ABC) transporter HUT08_RS13200 ENOG4108JQ9 ABC transporter HUT08_RS13205 ENOG4105DIH basic membrane HUT08_RS13210 ENOG4107RM1 amidohydrolase HUT08_RS13220 ENOG4105D2T synthase HUT08_RS13235 ENOG4105K64 Glycosyl transferase, family 2 HUT08_RS13270 ENOG4105C6Z Gluconate HUT08_RS13275 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT08_RS13280 ENOG4105C6F GntR Family Transcriptional Regulator HUT08_RS13285 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS13310 ENOG4108MMM RNA Polymerase HUT08_RS13320 ENOG4105E2D ec 3.2.1.52 HUT08_RS13340 ENOG4108J01 L-aspartate oxidase HUT08_RS13345 ENOG4105E33 succinate dehydrogenase HUT08_RS13365 ENOG4107RN3 metallophosphoesterase HUT08_RS13385 ENOG4107H3J ribonuclease HUT08_RS13390 ENOG4105EEM helicase HUT08_RS13405 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT08_RS13410 ENOG4105C8Y Acetylornithine aminotransferase HUT08_RS13415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS13420 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT08_RS13435 ENOG4108HQS Glycine betaine HUT08_RS13465 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUT08_RS13480 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT08_RS13485 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT08_RS13525 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT08_RS13530 ENOG4105DEG Vwa containing coxe family protein HUT08_RS13545 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT08_RS13580 ENOG41081JD Transcriptional regulator HUT08_RS13590 ENOG4108ZJ4 polysaccharide deacetylase HUT08_RS13595 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS13640 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT08_RS13660 ENOG4105C26 Dehydrogenase HUT08_RS13665 ENOG4108DT4 serine threonine protein kinase HUT08_RS13710 ENOG41082AN stage II sporulation protein HUT08_RS13755 ENOG4105CJ1 ABC, transporter HUT08_RS13880 ENOG4105EC2 ftsk spoIIIe HUT08_RS13890 ENOG4108XEP Alpha Beta Hydrolase Fold protein HUT08_RS13900 ENOG4108SU4 UPF0309 protein HUT08_RS13915 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT08_RS13930 ENOG4105KME endoribonuclease L-psp HUT08_RS13935 ENOG4105M4P Tetr family transcriptional regulator HUT08_RS14035 ENOG4107QX3 carboxylase HUT08_RS14050 ENOG4107B2H carbonic anhydrase HUT08_RS14065 ENOG4105CQB FAD linked oxidase domain protein HUT08_RS14095 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT08_RS14115 ENOG4108ZHR arsR family transcriptional regulator HUT08_RS14120 ENOG4105C57 major facilitator superfamily HUT08_RS14125 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT08_RS14180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS14185 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT08_RS14190 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT08_RS14210 ENOG4105CPC Aldo Keto reductase HUT08_RS14250 ENOG4105C7N Xanthine uracil vitamin C permease HUT08_RS14260 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT08_RS14290 ENOG4108N0W Major Facilitator superfamily HUT08_RS14300 ENOG4108UIH futalosine nucleosidase HUT08_RS14305 ENOG4105E63 Pfam:DUF178 HUT08_RS14310 ENOG4107R72 Ceramidase HUT08_RS14320 ENOG4105VEQ Cold shock protein HUT08_RS14335 ENOG4105DQ5 transport system permease protein HUT08_RS14340 ENOG4105TVJ transport system, permease HUT08_RS14345 ENOG4105E0A ABC, transporter HUT08_RS14375 ENOG4105KZX Pterin carbinolamine dehydratase HUT08_RS14410 ENOG4105CFI type iii restriction protein res subunit HUT08_RS14420 ENOG4105EEM helicase HUT08_RS14440 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT08_RS14445 ENOG4106N3A copper homeostasis protein cutc HUT08_RS14470 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT08_RS14475 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT08_RS14480 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT08_RS14485 ENOG4105VEQ Cold shock protein HUT08_RS14495 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT08_RS14500 ENOG4105C3Q Glycosyl transferase, family 2 HUT08_RS14510 ENOG4105VNY Trehalose 6-phosphate phosphatase HUT08_RS14530 ENOG4105CE4 GlcNAc 6-P deacetylase HUT08_RS14535 ENOG4106VEM tagatose-6-phosphate kinase HUT08_RS14550 ENOG4105BZU Histidine kinase HUT08_RS14555 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT08_RS14560 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT08_RS14600 ENOG4105CPN adenine deaminase HUT08_RS14610 ENOG4107TXC Transcriptional regulator HUT08_RS14625 ENOG4108VHT MarR family transcriptional regulator HUT08_RS14650 ENOG4105YVS arsR family transcriptional regulator HUT08_RS14655 ENOG4108ISG Major Facilitator HUT08_RS14685 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT08_RS14720 ENOG41083TI Protein CrcB homolog HUT08_RS14795 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT08_RS14805 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT08_RS14810 ENOG4105C8N cysteinyl-tRNA synthetase HUT08_RS14820 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT08_RS14825 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT08_RS14830 ENOG4108VJ1 Transcriptional regulator (CarD family HUT08_RS14845 ENOG4105BZU Histidine kinase HUT08_RS14875 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT08_RS14895 ENOG4108YZJ Pfam:DUF2596 HUT08_RS14900 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT08_RS14915 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT08_RS14965 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT08_RS14970 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT08_RS14975 ENOG4105CGH 5'-nucleotidase HUT08_RS14980 ENOG4105C22 threonyL-tRNA synthetase HUT08_RS15005 ENOG4105DDN Pentapeptide repeat-containing protein HUT08_RS15010 ENOG4108VBZ doxx family HUT08_RS15025 ENOG4105MKU Transcriptional regulator HUT08_RS15035 ENOG41062D9 Histidine kinase HUT08_RS15045 ENOG4105C0H protease HUT08_RS15050 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS15070 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS15075 ENOG4105ETE Transcriptional regulator (LacI family HUT08_RS15080 ENOG4107NHD transcriptional regulator HUT08_RS15090 ENOG4108XDN Transcriptional regulator HUT08_RS15120 ENOG4105KHC sulfurtransferase HUT08_RS15125 ENOG4105PKJ carbohydrate binding HUT08_RS15140 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT08_RS15145 ENOG4105EHG Permease protein HUT08_RS15150 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT08_RS15160 ENOG41090R7 Ferric uptake HUT08_RS15165 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT08_RS15180 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT08_RS15195 ENOG4105HHS UPF0256 protein HUT08_RS15200 ENOG4108Z4X TRANSCRIPTIONal HUT08_RS15210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUT08_RS15215 ENOG4105KVH Transcriptional regulator HUT08_RS15220 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT08_RS15240 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT08_RS15255 ENOG4105DZ2 Transcriptional regulator HUT08_RS15260 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HUT08_RS15270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT08_RS15275 ENOG4108KPJ rna polymerase sigma factor HUT08_RS15315 ENOG4107SCK Monooxygenase HUT08_RS15400 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT08_RS15405 ENOG4105CJ3 phosphate transporter HUT08_RS15415 ENOG4105VPX protein, conserved in bacteria HUT08_RS15430 ENOG4105DNP FAD linked oxidase domain protein HUT08_RS15435 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUT08_RS15440 ENOG4105E4C Lytic transglycosylase catalytic HUT08_RS15500 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT08_RS15505 ENOG4105II7 pyrroline-5-carboxylate reductase HUT08_RS15510 ENOG4105EYF MMPL domain protein HUT08_RS15610 ENOG4105C01 Dihydroxy-acid dehydratase HUT08_RS15620 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT08_RS15625 ENOG4107R33 ppx gppa phosphatase HUT08_RS15630 ENOG4108Z6Z Transcriptional regulator HUT08_RS15640 ENOG4108JWX HUT08_RS15655 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT08_RS15665 ENOG4108JQ1 Dehydrogenase HUT08_RS15685 ENOG41075QH Lipoprotein CseA HUT08_RS15690 ENOG4108PYU two-component system response regulator HUT08_RS15695 ENOG4108FKE two-component system sensor kinase HUT08_RS15725 ENOG4105DR5 peptidase HUT08_RS15775 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT08_RS15785 ENOG4108IYU L-aspartate oxidase HUT08_RS15790 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT08_RS15810 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS15825 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS15835 ENOG4108HQR Glycine betaine HUT08_RS15845 ENOG4105E90 ABC transporter HUT08_RS15850 ENOG4108IJ8 ABC transporter HUT08_RS15860 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUT08_RS15890 ENOG4105EUJ GTP cyclohydrolase i HUT08_RS15905 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT08_RS15920 ENOG4105F0N pyrophosphate phospho-hydrolase HUT08_RS15935 ENOG41082VC UPF0145 protein HUT08_RS15940 ENOG4107TXC Transcriptional regulator HUT08_RS15945 ENOG4108NIW Leucine export protein LeuE HUT08_RS15965 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT08_RS15975 ENOG4105CS1 NAD(P)H quinone oxidoreductase HUT08_RS16005 ENOG4105C26 Dehydrogenase HUT08_RS16025 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT08_RS16035 ENOG4105NRA 50s ribosomal protein l31 type b HUT08_RS16040 ENOG4105W0E 50S ribosomal protein L33 HUT08_RS16045 ENOG4105KDC 50s ribosomal protein l28 HUT08_RS16055 ENOG4105C2M dna polymerase I HUT08_RS16080 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HUT08_RS16095 ENOG4108JIK carboxylase HUT08_RS16105 ENOG4105D8K carboxyl transferase HUT08_RS16110 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUT08_RS16135 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUT08_RS16145 ENOG4105CHR reductase HUT08_RS16170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT08_RS16180 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT08_RS16215 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT08_RS16220 ENOG4105KVH Transcriptional regulator HUT08_RS16225 ENOG4108IG5 Transcriptional regulator HUT08_RS16235 ENOG4108KPJ rna polymerase sigma factor HUT08_RS16240 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT08_RS16280 ENOG4105CHM Aminotransferase HUT08_RS16285 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT08_RS16290 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT08_RS16295 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS16300 ENOG4105ENE Histidine kinase HUT08_RS16305 ENOG4107R13 MMPL domain protein HUT08_RS16310 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT08_RS16325 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT08_RS16355 ENOG4105M6F mutator MutT protein HUT08_RS16365 ENOG4105DZH s-adenosylmethionine synthetase (EC 2.5.1.6) HUT08_RS16375 ENOG4105CVJ phosphoglycerate mutase HUT08_RS16380 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT08_RS16465 ENOG4105C6E dna polymerase iii HUT08_RS16470 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT08_RS16475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT08_RS16485 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT08_RS16495 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT08_RS16505 ENOG4105WN5 stage II sporulation protein HUT08_RS16510 ENOG4108I5C dEAD DEAH box helicase HUT08_RS16575 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT08_RS16580 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT08_RS16590 ENOG4105D74 hydrolase HUT08_RS16620 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT08_RS16665 ENOG4105BZ4 penicillin-binding protein HUT08_RS16710 ENOG4105ETE Transcriptional regulator (LacI family HUT08_RS16765 ENOG4105C5S asparaginyl-tRNA synthetase HUT08_RS16820 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT08_RS16835 ENOG4105DZR Type I site-specific deoxyribonuclease HUT08_RS16845 ENOG4105CVR type I restriction-modification system HUT08_RS16905 ENOG4105DR4 Methyltransferase HUT08_RS16925 ENOG4105NAF rna polymerase sigma factor HUT08_RS16935 ENOG4105CFH Aspartokinase HUT08_RS16950 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT08_RS16955 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT08_RS16975 ENOG4107T65 Integrase HUT08_RS16980 ENOG4106CY5 excisionase HUT08_RS16985 ENOG4107ZVI PhiRv2 prophage protein HUT08_RS17065 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS17070 ENOG4107Y2X deaminase HUT08_RS17160 ENOG4105CVK Glutamate decarboxylase HUT08_RS17175 ENOG4105C5H ABC transporter HUT08_RS17195 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT08_RS17230 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HUT08_RS17255 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT08_RS17290 ENOG4106KE4 Dehydrogenase HUT08_RS17330 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT08_RS17345 ENOG4108Z6B deaminase HUT08_RS17360 ENOG4105CUB amino acid HUT08_RS17410 ENOG4108KTG Membrane protein, drug metabolite transporter HUT08_RS17435 ENOG4107WA4 MmpL domain-containing protein HUT08_RS17445 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS17465 ENOG4105CT1 (ABC) transporter HUT08_RS17490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS17500 ENOG4105EMN RNA polymerase sigma factor HUT08_RS17525 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HUT08_RS17530 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT08_RS17535 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT08_RS17545 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT08_RS17555 ENOG4108YYC ycei family HUT08_RS17565 ENOG4105C57 major facilitator superfamily HUT08_RS17570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT08_RS17665 ENOG4105VTR Integrase HUT08_RS17685 ENOG4108UXN response regulator HUT08_RS17700 ENOG4105JQZ Methyltransferase HUT08_RS17715 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS17725 ENOG4105NAF rna polymerase sigma factor HUT08_RS17745 ENOG4105C5Q Transcriptional regulator HUT08_RS17750 ENOG4105CHR reductase HUT08_RS17755 ENOG4105CHR reductase HUT08_RS17765 ENOG4105C0H protease HUT08_RS17780 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT08_RS17795 ENOG4107T6F Xaa-Pro aminopeptidase HUT08_RS17805 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT08_RS17855 ENOG4105JDN Copper resistance protein HUT08_RS17860 ENOG4105DBE peroxidase HUT08_RS17865 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT08_RS17875 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT08_RS17900 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT08_RS17910 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT08_RS17915 ENOG410667J hydrolase HUT08_RS17950 ENOG4106T9R serine protease HUT08_RS17970 ENOG4105JXH GntR family transcriptional regulator HUT08_RS17975 ENOG4105DJ2 Major Facilitator Superfamily HUT08_RS17990 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT08_RS18050 ENOG4107SWG transcriptional regulator MERR family HUT08_RS18065 ENOG4105D0M Protease HtpX homolog HUT08_RS18085 ENOG4108KP7 hydrolase HUT08_RS18105 ENOG4108JJ9 ABC, transporter HUT08_RS18110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT08_RS18115 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT08_RS18120 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT08_RS18125 ENOG4107P2S Transcriptional regulator HUT08_RS18130 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HUT08_RS18140 ENOG4105C5Q Transcriptional regulator HUT08_RS18145 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT08_RS18160 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT08_RS18185 ENOG4106048 Cupin 2, conserved barrel domain protein HUT08_RS18190 ENOG41082T9 Membrane HUT08_RS18195 ENOG4105C28 cystathionine HUT08_RS18230 ENOG4105F27 Major Facilitator HUT08_RS18295 ENOG4105I6B RNA polymerase HUT08_RS18315 ENOG4105CDU Replicative dna helicase HUT08_RS18320 ENOG4107QI1 Mate efflux family protein HUT08_RS18325 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT08_RS18330 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT08_RS18335 ENOG4107YH6 single-stranded DNA-binding protein HUT08_RS18340 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT08_RS18365 ENOG4105BZ4 penicillin-binding protein HUT08_RS18385 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT08_RS18415 ENOG4105C3M thioredoxin reductase HUT08_RS18420 ENOG4105K63 Thioredoxin HUT08_RS18435 ENOG4107QJE Chromosome Partitioning Protein HUT08_RS18440 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT08_RS18450 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT08_RS18455 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT08_RS18465 ENOG41084CH 50S ribosomal protein l34 HUT08_RS18475 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT08_RS18480 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT08_RS18485 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT08_RS18490 ENOG4105K7N UPF0232 protein HUT08_RS18500 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT08_RS18545 ENOG4106F60 Histidine kinase HUT08_RS18550 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT08_RS18570 ENOG4105CPF Cell wall formation (By similarity) HUT08_RS18575 ENOG4108UQS dipeptidase HUT08_RS18600 ENOG4105ZJT Cell division protein CrgA HUT08_RS18620 ENOG4108U4N (sortase) family HUT08_RS18625 ENOG4108RN7 integral membrane protein HUT08_RS18635 ENOG4105CJN penicillin-binding protein HUT08_RS18640 ENOG4107QHZ cell cycle protein HUT08_RS18650 ENOG4105HZM Fha domain containing protein HUT08_RS18655 ENOG4105TV9 FHA Domain-Containing protein HUT08_RS18665 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT08_RS18670 ENOG4105KVH Transcriptional regulator HUT08_RS18690 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HUT08_RS18695 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT08_RS18700 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT08_RS18705 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT08_RS18710 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT08_RS18715 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT08_RS18740 ENOG4105KPY Small multidrug resistance protein HUT08_RS18760 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT08_RS18785 ENOG4107QSN dihydrolipoamide acetyltransferase HUT08_RS18790 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUT08_RS18805 ENOG4107SVH Potassium channel protein HUT08_RS18820 ENOG4108VC7 Protein of unknown function (DUF2587) HUT08_RS18825 ENOG4107QPV Serine Threonine protein kinase HUT08_RS18855 ENOG4105CPP Dehydrogenase, E1 component HUT08_RS18860 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT08_RS18925 ENOG4105RNG membrane HUT08_RS18930 ENOG4105K6V RNA polymerase HUT08_RS18955 ENOG4105DFM M18 family aminopeptidase HUT08_RS18960 ENOG4105CSU acyl-Coa dehydrogenase HUT08_RS18970 ENOG4105EUB pirin domain protein HUT08_RS19000 ENOG4105C9M aspartyl-trna synthetase HUT08_RS19010 ENOG4105EW9 transcriptional regulator AsnC family HUT08_RS19035 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT08_RS19040 ENOG4105MUA Resistance protein HUT08_RS19060 ENOG4105DXX methyltransferase HUT08_RS19065 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS19110 ENOG4105DQE DNA ligase HUT08_RS19140 ENOG4107RSM transcriptional regulator HUT08_RS19200 ENOG4105MHT Transcriptional regulator, ARSR family HUT08_RS19250 ENOG4105NAF rna polymerase sigma factor HUT08_RS19260 ENOG4105E7U AraC family transcriptional regulator HUT08_RS19375 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT08_RS19450 ENOG41060M0 Crispr-associated protein, cse4 family HUT08_RS19455 ENOG4108VWQ crispr-associated protein HUT08_RS19515 ENOG4105EC2 ftsk spoIIIe HUT08_RS19610 ENOG41067SE Tetr family transcriptional regulator HUT08_RS19615 ENOG4105CPC Aldo Keto reductase HUT08_RS19625 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HUT08_RS19655 ENOG4105DQ5 transport system permease protein HUT08_RS19660 ENOG4105TVJ transport system, permease HUT08_RS19665 ENOG4105E0A ABC, transporter HUT08_RS19685 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT08_RS19695 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HUT08_RS19715 ENOG4108KEZ Dehydrogenase HUT08_RS19730 ENOG4107S9F NmrA family HUT08_RS19755 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT08_RS19780 ENOG4105DHP deoxycytidine triphosphate deaminase HUT08_RS19810 ENOG4105DF6 Fe-S oxidoreductase HUT08_RS19815 ENOG4105CFG Acts as a chaperone (By similarity) HUT08_RS19820 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT08_RS19825 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT08_RS19830 ENOG4105KNI merR family transcriptional Regulator HUT08_RS19850 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT08_RS19875 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT08_RS19905 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUT08_RS19910 ENOG4107RCW fructose-bisphosphate aldolase HUT08_RS19930 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT08_RS19945 ENOG4105DIM ABC transporter HUT08_RS19950 ENOG4105CIG ABC transporter HUT08_RS19965 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT08_RS19975 ENOG4108JPW Aminotransferase HUT08_RS19980 ENOG4108WYP Transcriptional regulator HUT08_RS19995 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT08_RS20010 ENOG4105C8V SAICAR synthetase HUT08_RS20035 ENOG410839H phosphoribosylformylglycinamidine synthase HUT08_RS20040 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT08_RS20045 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT08_RS20055 ENOG41061MV Arylsulfatase HUT08_RS20065 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS20080 ENOG4108KPJ rna polymerase sigma factor HUT08_RS20085 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT08_RS20105 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HUT08_RS20125 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT08_RS20135 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT08_RS20150 ENOG4108TAC HUT08_RS20355 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT08_RS20365 ENOG4107QQG Dehydrogenase HUT08_RS20525 ENOG4105E4C Lytic transglycosylase catalytic HUT08_RS20605 ENOG4108Q9V regulatoR HUT08_RS20610 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT08_RS20640 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HUT08_RS20665 ENOG4105C1J atp-dependent rna helicase HUT08_RS20700 ENOG4105VBF alkaline shock protein HUT08_RS20710 ENOG4105KVH Transcriptional regulator HUT08_RS20755 ENOG4107SET aldo keto reductase HUT08_RS20775 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HUT08_RS20805 ENOG4105PFC Transcriptional regulator HUT08_RS20840 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS20850 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT08_RS20860 ENOG4105D5U fad dependent oxidoreductase HUT08_RS20885 ENOG4106IDA glycerophosphoryl diester phosphodiesterase HUT08_RS20940 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT08_RS20945 ENOG4105DGU Histone deacetylase HUT08_RS20950 ENOG4108XFF HUT08_RS20995 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT08_RS21000 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT08_RS21005 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT08_RS21010 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT08_RS21015 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT08_RS21030 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS21050 ENOG4105EQK -acetyltransferase HUT08_RS21060 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT08_RS21065 ENOG4108KPJ rna polymerase sigma factor HUT08_RS21100 ENOG4105C75 arginyL-tRNA synthetase HUT08_RS21105 ENOG4105DK7 lysyl-tRNA synthetase HUT08_RS21130 ENOG4105E0Y RtcB Protein HUT08_RS21140 ENOG4105KVH Transcriptional regulator HUT08_RS21155 ENOG4107S5I aldo keto reductase HUT08_RS21165 ENOG4105KK4 UPF0060 membrane protein HUT08_RS21175 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT08_RS21200 ENOG4105CHR reductase HUT08_RS21245 ENOG4105EBR Carboxylesterase HUT08_RS21250 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT08_RS21355 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HUT08_RS21370 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT08_RS21375 ENOG4108RH7 phosphoglycerate mutase HUT08_RS21395 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HUT08_RS21415 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUT08_RS21420 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT08_RS21425 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUT08_RS21435 ENOG4105DVY radical SAM domain protein HUT08_RS21440 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HUT08_RS21455 ENOG4107QJT sodium dicarboxylate symporter HUT08_RS21460 ENOG4108R86 Transcriptional regulator HUT08_RS21470 ENOG4105VEQ Cold shock protein HUT08_RS21475 ENOG4105EV6 Pfam:DUF178 HUT08_RS21485 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT08_RS21495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS21500 ENOG4108R0M Aminoglycoside HUT08_RS21510 ENOG4105KNA -acetyltransferase HUT08_RS21680 ENOG4108PNI recT protein HUT08_RS21685 ENOG4108NF7 phage-type endonuclease HUT08_RS21760 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21765 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT08_RS21770 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21780 ENOG4107QIZ NADH dehydrogenase HUT08_RS21785 ENOG4108IEH NADH dehydrogenase subunit g HUT08_RS21790 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT08_RS21795 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21800 ENOG41087XN oxidoreductase HUT08_RS21805 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21810 ENOG4105D65 subunit l HUT08_RS21820 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21830 ENOG4105ERH Fumarylacetoacetate hydrolase HUT08_RS21860 ENOG4105IIU Aminopeptidase HUT08_RS21900 ENOG4105ECR NmrA family HUT08_RS21905 ENOG4105KVH Transcriptional regulator HUT08_RS21910 ENOG4105DQU oxidoreductase, subunit beta HUT08_RS21915 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT08_RS21935 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT08_RS21940 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21945 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT08_RS21950 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT08_RS21955 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21965 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21970 ENOG4105D65 subunit l HUT08_RS21975 ENOG4105C8S subunit m HUT08_RS21980 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT08_RS21985 ENOG4105D0M Protease HtpX homolog HUT08_RS21990 ENOG410901E Membrane HUT08_RS22000 ENOG4108VPT UPF0234 protein HUT08_RS22030 ENOG4105DZC cytosine deaminase HUT08_RS22045 ENOG4105WDJ 50S ribosomal protein L33 HUT08_RS22050 ENOG410900P UPF0336 protein HUT08_RS22070 ENOG4107R4N Cell wall formation (By similarity) HUT08_RS22105 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUT08_RS22110 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT08_RS22115 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT08_RS22125 ENOG4108VZM 50s ribosomal protein L10 HUT08_RS22130 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT08_RS22135 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT08_RS22140 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT08_RS22150 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT08_RS22155 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT08_RS22160 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT08_RS22165 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT08_RS22190 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT08_RS22195 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT08_RS22200 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT08_RS22205 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT08_RS22210 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT08_RS22215 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT08_RS22220 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT08_RS22225 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT08_RS22230 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT08_RS22235 ENOG41082SA 50s ribosomal protein l29 HUT08_RS22240 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT08_RS22245 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT08_RS22250 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT08_RS22255 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT08_RS22260 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT08_RS22265 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT08_RS22270 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT08_RS22275 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT08_RS22280 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT08_RS22290 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT08_RS22300 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT08_RS22310 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT08_RS22320 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT08_RS22325 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT08_RS22330 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT08_RS22335 ENOG4108ZT0 50S ribosomal protein l17 HUT08_RS22340 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT08_RS22345 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HUT08_RS22355 ENOG4105C5H ABC transporter HUT08_RS22360 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT08_RS22365 ENOG4108UJD 30S ribosomal protein S9 HUT08_RS22370 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT08_RS22395 ENOG4105CGD Nad-dependent epimerase dehydratase HUT08_RS22400 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT08_RS22500 ENOG4105CS9 pantothenic acid kinase HUT08_RS22505 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT08_RS22520 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT08_RS22530 ENOG4108097 ATP-binding protein HUT08_RS22550 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT08_RS22565 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS22590 ENOG4107QVI Methyltransferase, type 11 HUT08_RS22600 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT08_RS22610 ENOG4105EMU Dehydrogenase HUT08_RS22620 ENOG4105DND Transcriptional regulator HUT08_RS22625 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT08_RS22630 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS22635 ENOG4108MMM RNA Polymerase HUT08_RS22650 ENOG4107QVP Dehydrogenase HUT08_RS22665 ENOG4105DFF Rod shape-determining protein mreb HUT08_RS22675 ENOG4107QQG Dehydrogenase HUT08_RS22695 ENOG4107TPY serine threonine protein kinase HUT08_RS22715 ENOG4105H3G oxidoreductase HUT08_RS22725 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT08_RS22735 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS22740 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT08_RS22750 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS22780 ENOG4108762 serine threonine protein kinase HUT08_RS22805 ENOG4105F0K SARP family transcriptional regulator HUT08_RS22825 ENOG4105F0K SARP family transcriptional regulator HUT08_RS22830 ENOG4105CUB amino acid HUT08_RS22845 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT08_RS22850 ENOG41086D8 Transcriptional regulator HUT08_RS22860 ENOG41065RQ ADP-ribosylation crystallin J1 HUT08_RS22865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS22885 ENOG4105DZ1 carboxypeptidase HUT08_RS22895 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HUT08_RS22905 ENOG4107TXC Transcriptional regulator HUT08_RS22915 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT08_RS22925 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT08_RS22940 ENOG4105HS2 Arsenate reductase HUT08_RS22945 ENOG4107YCR Transcriptional regulator, ARSR family HUT08_RS23015 ENOG4105EJ2 Transcriptional regulator HUT08_RS23050 ENOG4105KXX peptidase s58 dmpa HUT08_RS23055 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT08_RS23065 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT08_RS23075 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT08_RS23090 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HUT08_RS23100 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT08_RS23105 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT08_RS23115 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT08_RS23120 ENOG4105EPU Molybdenum cofactor synthesis domain protein HUT08_RS23125 ENOG4105D9U N-acetyltransferase HUT08_RS23145 ENOG4105CHP RNA polymerase HUT08_RS23150 ENOG4105GRZ Ycii-related protein HUT08_RS23165 ENOG4105C5Q Transcriptional regulator HUT08_RS23200 ENOG4105CGK Exodeoxyribonuclease III HUT08_RS23210 ENOG4105F95 Monooxygenase HUT08_RS23215 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT08_RS23220 ENOG4108BAS reductase HUT08_RS23240 ENOG4105EYF MMPL domain protein HUT08_RS23300 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS23315 ENOG4105ERR inositol mono-phosphatase HUT08_RS23335 ENOG4105D3W isochorismatase HUT08_RS23355 ENOG4105F8V Hydrolase, tatD family HUT08_RS23360 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT08_RS23365 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT08_RS23370 ENOG4105C5H ABC transporter HUT08_RS23405 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT08_RS23415 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS23420 ENOG4108ZT1 Transcriptional regulator HUT08_RS23425 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT08_RS23440 ENOG4108RZE Tetr family transcriptional regulator HUT08_RS23450 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT08_RS23475 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT08_RS23480 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT08_RS23485 ENOG4105CJN penicillin-binding protein HUT08_RS23490 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS23500 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT08_RS23505 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT08_RS23555 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT08_RS23560 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT08_RS23565 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT08_RS23575 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUT08_RS23630 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT08_RS23660 ENOG4105C7B Threonine dehydratase HUT08_RS23675 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT08_RS23685 ENOG4105T1M mycothiol conjugate amidase mca HUT08_RS23695 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT08_RS23700 ENOG4105C7Z Conserved Protein HUT08_RS23705 ENOG4105CPQ Dehydrogenase HUT08_RS23715 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT08_RS23725 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT08_RS23770 ENOG4108FUF Transcriptional regulator, IclR family HUT08_RS23775 ENOG4105KME endoribonuclease L-psp HUT08_RS23780 ENOG4105C6Z Gluconate HUT08_RS23815 ENOG4105U5Y Transcriptional regulator HUT08_RS23870 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT08_RS23985 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HUT08_RS23990 ENOG4105CPC Aldo Keto reductase HUT08_RS23995 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT08_RS24000 ENOG4108IAB Phoh family HUT08_RS24015 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT08_RS24020 ENOG4105D3R alkyl hydroperoxide reductase HUT08_RS24040 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT08_RS24060 ENOG4105BZ4 penicillin-binding protein HUT08_RS24070 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT08_RS24080 ENOG4105C9Q fumarate hydratase class II HUT08_RS24090 ENOG4107GFK fumarate HUT08_RS24100 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT08_RS24115 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT08_RS24120 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT08_RS24125 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT08_RS24140 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT08_RS24155 ENOG4105C3G gtp-binding protein HUT08_RS24160 ENOG41084HI prevent-host-death family HUT08_RS24165 ENOG4105KRQ Addiction module toxin, Txe YoeB family HUT08_RS24185 ENOG4105F27 Major Facilitator HUT08_RS24200 ENOG4105ECQ AraC Family Transcriptional Regulator HUT08_RS24230 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS24245 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT08_RS24260 ENOG41067QW Transcriptional regulator HUT08_RS24275 ENOG4105CHP RNA polymerase HUT08_RS24300 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT08_RS24315 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT08_RS24320 ENOG4105EAH synthase HUT08_RS24390 ENOG4105CI3 gtp-binding protein typa HUT08_RS24400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT08_RS24405 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT08_RS24415 ENOG4108JQ7 (ABC) transporter HUT08_RS24460 ENOG4105D9U N-acetyltransferase HUT08_RS24465 ENOG4105D9U N-acetyltransferase HUT08_RS24510 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT08_RS24525 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT08_RS24530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT08_RS24535 ENOG4105C3U ABC transporter HUT08_RS24540 ENOG4108JQ7 (ABC) transporter HUT08_RS24605 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT08_RS24640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT08_RS24665 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT08_RS24690 ENOG4108Z4U Ferredoxin HUT08_RS24710 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT08_RS24715 ENOG4108URH decarboxylase HUT08_RS24720 ENOG4105EEI dihydropteroate synthase HUT08_RS24730 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT08_RS24735 ENOG4105CGU Enoyl-CoA hydratase HUT08_RS24750 ENOG4105DU6 RNA polymerase HUT08_RS24760 ENOG4105C0H protease HUT08_RS24765 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT08_RS24810 ENOG4105D7N magnesium and cobalt transport protein CorA HUT08_RS24820 ENOG4105DXB Major Facilitator superfamily HUT08_RS24830 ENOG4105DB7 PHP domain protein HUT08_RS24835 ENOG41081FY multiple antibiotic resistance (MarC)-related HUT08_RS24905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT08_RS24915 ENOG4108JQ6 ABC transporter HUT08_RS24985 ENOG4105C4R Atp-dependent dna helicase HUT08_RS24990 ENOG4105C4R Atp-dependent dna helicase HUT08_RS24995 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT08_RS25020 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT08_RS25030 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HUT08_RS25085 ENOG41063PX domain protein HUT08_RS25095 ENOG4105DJZ UPF0182 protein HUT08_RS25115 ENOG4105CIJ rieske 2fe-2S domain-containing protein HUT08_RS25135 ENOG4107TK4 histidinol-phosphate phosphatase HUT08_RS25155 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT08_RS25165 ENOG4108RAV Conserved protein HUT08_RS25175 ENOG4105EMN RNA polymerase sigma factor HUT08_RS25200 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT08_RS25210 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT08_RS25215 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT08_RS25225 ENOG4105D22 carbon starvation protein HUT08_RS25235 ENOG4105FDP GntR family transcriptional regulator HUT08_RS25255 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT08_RS25260 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT08_RS25265 ENOG4108IND Tetr family transcriptional regulator HUT08_RS25280 ENOG4105CBD Diacylglycerol kinase HUT08_RS25295 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT08_RS25325 ENOG4105CSV Glutaminase HUT08_RS25330 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT08_RS25340 ENOG4105D7N magnesium and cobalt transport protein CorA HUT08_RS25355 ENOG4108VEQ Superoxide dismutase HUT08_RS25370 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT08_RS25375 ENOG4105CDA abc transporter atp-binding protein HUT08_RS25380 ENOG4105E5Q amino acid AbC transporter HUT08_RS25390 ENOG4105C6K Malic enzyme HUT08_RS25395 ENOG4105CB2 alcohol dehydrogenase HUT08_RS25435 ENOG4105C0W non-ribosomal peptide synthetase HUT08_RS25450 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT08_RS25485 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT08_RS25525 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT08_RS25530 ENOG4105EB3 Histidine kinase HUT08_RS25540 ENOG4108PYU two-component system response regulator HUT08_RS25575 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS25580 ENOG4105BZU Histidine kinase HUT08_RS25585 ENOG4105EYF MMPL domain protein HUT08_RS25590 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT08_RS25595 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HUT08_RS25610 ENOG4105EYF MMPL domain protein HUT08_RS25690 ENOG4105CHR reductase HUT08_RS25710 ENOG4105XYF acetyltransferase HUT08_RS25735 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT08_RS25765 ENOG4107R13 MMPL domain protein HUT08_RS25775 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS25790 ENOG4108KB0 deacetylase HUT08_RS25810 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT08_RS25830 ENOG4107QQG Dehydrogenase HUT08_RS25835 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT08_RS25840 ENOG4105DQU oxidoreductase, subunit beta HUT08_RS25855 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS25870 ENOG4105DGI Alkaline phosphatase HUT08_RS25885 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS25905 ENOG4108JA1 polyketide synthase HUT08_RS25940 ENOG4105EYF MMPL domain protein HUT08_RS25945 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT08_RS25985 ENOG4107S5I aldo keto reductase HUT08_RS26030 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT08_RS26045 ENOG41061AU MarR family Transcriptional regulator HUT08_RS26095 ENOG4105C75 arginyL-tRNA synthetase HUT08_RS26100 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT08_RS26105 ENOG4105D6E homoserine dehydrogenase HUT08_RS26110 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT08_RS26115 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT08_RS26125 ENOG4108KGH TRANSCRIPTIONal HUT08_RS26130 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT08_RS26135 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT08_RS26140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT08_RS26150 ENOG4107ZF2 Phosphatase HUT08_RS26155 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT08_RS26165 ENOG4105Z3P ATP synthase HUT08_RS26175 ENOG4105ZA1 atp synthase HUT08_RS26180 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT08_RS26185 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT08_RS26190 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT08_RS26195 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT08_RS26200 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT08_RS26205 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT08_RS26225 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS26230 ENOG4105BZU Histidine kinase HUT08_RS26235 ENOG4105IIP Membrane HUT08_RS26255 ENOG410630P Transcriptional regulator HUT08_RS26260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT08_RS26275 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT08_RS26330 ENOG4105CHU acetyl-coa acetyltransferase HUT08_RS26345 ENOG4105ETX regulatoR HUT08_RS26400 ENOG4105WX6 Membrane HUT08_RS26450 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT08_RS26455 ENOG4105C6K Malic enzyme HUT08_RS26460 ENOG4105CTQ phosphohexokinase HUT08_RS26500 ENOG4105EG2 ABC transporter, permease HUT08_RS26505 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT08_RS26520 ENOG4106YYS transcriptional regulatory protein HUT08_RS26525 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT08_RS26530 ENOG4107QJT sodium dicarboxylate symporter HUT08_RS26535 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT08_RS26555 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT08_RS26560 ENOG4105KVH Transcriptional regulator HUT08_RS26565 ENOG4108J2P Alpha beta hydrolase fold HUT08_RS26585 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUT08_RS26615 ENOG4105F0K SARP family transcriptional regulator HUT08_RS26620 ENOG4105BZ1 (ABC) transporter HUT08_RS26625 ENOG4105BZ1 (ABC) transporter HUT08_RS26675 ENOG4108KXM LysR family Transcriptional regulator HUT08_RS26695 ENOG4105K63 Thioredoxin HUT08_RS26700 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS26705 ENOG4105C3M thioredoxin reductase HUT08_RS26725 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HUT08_RS26745 ENOG4108SUT Major Facilitator Superfamily HUT08_RS26760 ENOG4105CHP RNA polymerase HUT08_RS26775 ENOG4105EJQ L-serine dehydratase HUT08_RS26780 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT08_RS26785 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUT08_RS26790 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT08_RS26830 ENOG4108JQ7 (ABC) transporter HUT08_RS26835 ENOG4105EN6 Membrane HUT08_RS26880 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT08_RS26900 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT08_RS26905 ENOG4105BZU Histidine kinase HUT08_RS26915 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT08_RS26920 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT08_RS26930 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT08_RS26945 ENOG4108SUT Major Facilitator Superfamily HUT08_RS26950 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT08_RS26960 ENOG4105EYF MMPL domain protein HUT08_RS26965 ENOG4105DCI Phosphohydrolase HUT08_RS26975 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS26995 ENOG4105CPC Aldo Keto reductase HUT08_RS27005 ENOG4105BZU Histidine kinase HUT08_RS27015 ENOG4108ZP8 Acetolactate synthase small subunit HUT08_RS27020 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT08_RS27025 ENOG4108JQ1 Dehydrogenase HUT08_RS27060 ENOG4105C26 Dehydrogenase HUT08_RS27070 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT08_RS27075 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT08_RS27080 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT08_RS27085 ENOG4108YYC ycei family HUT08_RS27095 ENOG4105D8K carboxyl transferase HUT08_RS27115 ENOG4105GWZ Roadblock lc7 family protein HUT08_RS27135 ENOG4105GWZ Roadblock lc7 family protein HUT08_RS27150 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HUT08_RS27155 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT08_RS27185 ENOG41069M3 Transcriptional regulator HUT08_RS27190 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT08_RS27195 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT08_RS27205 ENOG4105K70 DNA-binding protein HUT08_RS27225 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT08_RS27230 ENOG4105CPF Cell wall formation (By similarity) HUT08_RS27250 ENOG4105DWF phosphomethylpyrimidine kinase HUT08_RS27255 ENOG4105VB9 50S ribosomal protein l28 HUT08_RS27260 ENOG4105DP4 dak2 domain fusion protein ylov HUT08_RS27270 ENOG4106H78 methyltransferase HUT08_RS27275 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT08_RS27290 ENOG41084BZ 50S ribosomal protein L32 HUT08_RS27295 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT08_RS27300 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT08_RS27305 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUT08_RS27360 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT08_RS27370 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HUT08_RS27380 ENOG4105K5M 30s ribosomal protein S16 HUT08_RS27385 ENOG41082KU UPF0109 protein HUT08_RS27390 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT08_RS27395 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT08_RS27400 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT08_RS27410 ENOG4107QYR Signal peptidase i HUT08_RS27415 ENOG4107QYR Signal peptidase i HUT08_RS27435 ENOG41080R2 UPF0102 protein HUT08_RS27570 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT08_RS27585 ENOG4105CE9 30S ribosomal protein S2 HUT08_RS27590 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT08_RS27595 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT08_RS27600 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT08_RS27610 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT08_RS27620 ENOG4108MP3 ABC transporter, permease HUT08_RS27625 ENOG4108UCS ABC, transporter HUT08_RS27635 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT08_RS27640 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT08_RS27650 ENOG4105C26 Dehydrogenase HUT08_RS27660 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT08_RS27695 ENOG4105G9B Transcriptional regulator HUT08_RS27710 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUT08_RS27715 ENOG4105DZP Membrane-associated zinc metalloprotease HUT08_RS27720 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT08_RS27735 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT08_RS27740 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HUT08_RS27755 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT08_RS27770 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT08_RS27780 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT08_RS27785 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT08_RS27815 ENOG4108T50 Protein of unknown function (DUF690) HUT08_RS27820 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS27835 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS27850 ENOG4105EC2 ftsk spoIIIe HUT08_RS27860 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT08_RS27865 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT08_RS27870 ENOG4105C1V Peptidase, M16 HUT08_RS27875 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT08_RS27900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT08_RS27905 ENOG4105CN5 Metallo-Beta-Lactamase HUT08_RS27925 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT08_RS27940 ENOG4105BZU Histidine kinase HUT08_RS27945 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT08_RS27950 ENOG4107QZI cell division protein FtsK HUT08_RS27960 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT08_RS27970 ENOG4105CEV competence damage-inducible protein HUT08_RS27975 ENOG4105WBV Transcriptional regulator HUT08_RS27980 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT08_RS27985 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT08_RS27990 ENOG4107QRT dEAD DEAH box helicase HUT08_RS28020 ENOG4105DSF transport protein HUT08_RS28030 ENOG4105KC9 Modulates RecA activity (By similarity) HUT08_RS28045 ENOG4107SCK Monooxygenase HUT08_RS28050 ENOG4105DRP amino acid AbC transporter HUT08_RS28055 ENOG4108Q1T ABC transporter HUT08_RS28060 ENOG4107UBR Extracellular solute-binding protein family 3 HUT08_RS28065 ENOG4105CDA abc transporter atp-binding protein HUT08_RS28075 ENOG4105EB3 Histidine kinase HUT08_RS28090 ENOG4105H1G trap transporter solute receptor taxi family HUT08_RS28095 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT08_RS28115 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT08_RS28125 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT08_RS28140 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT08_RS28170 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT08_RS28175 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT08_RS28180 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT08_RS28190 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUT08_RS28220 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT08_RS28235 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT08_RS28250 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT08_RS28255 ENOG4105C6F GntR Family Transcriptional Regulator HUT08_RS28260 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT08_RS28265 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT08_RS28275 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT08_RS28280 ENOG4108MRH transcriptional regulatory protein HUT08_RS28300 ENOG4105BZN citrate synthase HUT08_RS28305 ENOG4107QRP cobalamin biosynthesis protein CobW HUT08_RS28310 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT08_RS28330 ENOG410849S phosphocarrier protein (HPr) HUT08_RS28355 ENOG4107W53 thymidine kinase HUT08_RS28365 ENOG4105KHC sulfurtransferase HUT08_RS28390 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT08_RS28405 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT08_RS28410 ENOG4106F60 Histidine kinase HUT08_RS28435 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT08_RS28450 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT08_RS28455 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT08_RS28460 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUT08_RS28465 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT08_RS28515 ENOG4107VEG TrkA-N domain protein HUT08_RS28550 ENOG4105C0X amino acid HUT08_RS28555 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT08_RS28585 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT08_RS28620 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT08_RS28625 ENOG4108KXM LysR family Transcriptional regulator HUT08_RS28650 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT08_RS28660 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT08_RS28705 ENOG4107QK5 Homocysteine s-methyltransferase HUT08_RS28715 ENOG4107S1Q Phosphatase HUT08_RS28720 ENOG4105CEU Arginine dihydrolase HUT08_RS28725 ENOG4105DBV ornithine carbamoyltransferase HUT08_RS28730 ENOG4105CUB amino acid HUT08_RS28735 ENOG4108UKI Enoyl-CoA hydratase HUT08_RS28770 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS28780 ENOG4105TVJ transport system, permease HUT08_RS28785 ENOG4105DQ5 transport system permease protein HUT08_RS28795 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT08_RS28805 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS28825 ENOG4107QM5 aconitate hydratase HUT08_RS28845 ENOG4105E2R ROK family HUT08_RS28850 ENOG4105DFW ABC transporter HUT08_RS28855 ENOG4105C2J ABC transporter HUT08_RS28860 ENOG4108HWW ABC transporter HUT08_RS28865 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT08_RS28870 ENOG4105CUB amino acid HUT08_RS28895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT08_RS28900 ENOG4105CHU acetyl-coa acetyltransferase HUT08_RS28920 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT08_RS28925 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUT08_RS28930 ENOG4105QCJ Lipoprotein HUT08_RS28940 ENOG4105CHU acetyl-coa acetyltransferase HUT08_RS28945 ENOG4105C1Q protoporphyrinogen oxidase HUT08_RS28950 ENOG4107JTW chlorite dismutase HUT08_RS28965 ENOG4105E18 UPF0276 protein HUT08_RS28970 ENOG4105BZ4 penicillin-binding protein HUT08_RS29015 ENOG4105DFU Cell wall formation (By similarity) HUT08_RS29020 ENOG4105E0X reductase HUT08_RS29030 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS29050 ENOG4108KB2 LysR family Transcriptional regulator HUT08_RS29080 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HUT08_RS29100 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT08_RS29110 ENOG4108Z7F N-acetyltransferase HUT08_RS29135 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT08_RS29140 ENOG4108IY8 ABC, transporter HUT08_RS29160 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) HUT08_RS29165 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT08_RS29175 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUT08_RS29180 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT08_RS29205 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT08_RS29210 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT08_RS29220 ENOG4105VEQ Cold shock protein HUT08_RS29230 ENOG410832A alpha/beta hydrolase fold HUT08_RS29250 ENOG4105C7K acetolactate synthase HUT08_RS29305 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT08_RS29310 ENOG4105C7N Xanthine uracil vitamin C permease HUT08_RS29325 ENOG4105E18 UPF0276 protein HUT08_RS29340 ENOG4105DGI Alkaline phosphatase HUT08_RS29350 ENOG4105DYW oxidoreductase HUT08_RS29375 ENOG4105DKP glycosyl transferase, family 9 HUT08_RS29380 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT08_RS29385 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT08_RS29390 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT08_RS29405 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUT08_RS29420 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT08_RS29450 ENOG4105BZG amino acid carrier protein HUT08_RS29455 ENOG4105D7N magnesium and cobalt transport protein CorA HUT08_RS29475 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT08_RS29480 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS29485 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS29510 ENOG4105VT2 5-hydroxyisourate hydrolase HUT08_RS29520 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT08_RS29535 ENOG4106T9R serine protease HUT08_RS29545 ENOG4107R9S Malate synthase HUT08_RS29560 ENOG4108762 serine threonine protein kinase HUT08_RS29565 ENOG4108762 serine threonine protein kinase HUT08_RS29575 ENOG4107HP6 Transcriptional regulator HUT08_RS29605 ENOG4108UHU Aldolase HUT08_RS29620 ENOG41062B0 ABC transporter, permease HUT08_RS29625 ENOG4105C2J ABC transporter HUT08_RS29630 ENOG4105DKQ ROK family HUT08_RS29645 ENOG4108Z6Z Transcriptional regulator HUT08_RS29710 ENOG4108JA1 polyketide synthase HUT08_RS29715 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS29740 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUT08_RS29745 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT08_RS29765 ENOG4105CDA abc transporter atp-binding protein HUT08_RS29770 ENOG4107UBR Extracellular solute-binding protein family 3 HUT08_RS29775 ENOG4105EAD ABC transporter HUT08_RS29780 ENOG4105DRP amino acid AbC transporter HUT08_RS29790 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT08_RS29810 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HUT08_RS29830 ENOG4105ECY inositol monophosphatase HUT08_RS29860 ENOG4105MS9 Resuscitation-promoting factor HUT08_RS29885 ENOG4105C94 Transporter HUT08_RS29890 ENOG4105BZW Glycerate kinase HUT08_RS29900 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT08_RS29905 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS29915 ENOG4105CI0 Citrate lyase HUT08_RS29935 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT08_RS29955 ENOG4105C0B DNA polymerase III (alpha subunit) HUT08_RS29960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT08_RS29965 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HUT08_RS30000 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT08_RS30010 ENOG4107QQR Sporulation HUT08_RS30020 ENOG4108TKH Nitroreductase HUT08_RS30050 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT08_RS30055 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS30070 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT08_RS30095 ENOG4105F1J Homogentisate 1,2-dioxygenase HUT08_RS30100 ENOG4105D4T Citrate transporter HUT08_RS30140 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS30175 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS30180 ENOG4108IG5 Transcriptional regulator HUT08_RS30185 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS30205 ENOG4105VG5 Membrane HUT08_RS30210 ENOG4105PTV Nudix Hydrolase HUT08_RS30240 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT08_RS30260 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT08_RS30265 ENOG4105D3Q Sugar transferase HUT08_RS30330 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT08_RS30355 ENOG4107QYX exodeoxyribonuclease v alpha HUT08_RS30360 ENOG4105CPC Aldo Keto reductase HUT08_RS30365 ENOG4105DYW oxidoreductase HUT08_RS30375 ENOG4105D7N magnesium and cobalt transport protein CorA HUT08_RS30395 ENOG4105C8N cysteinyl-tRNA synthetase HUT08_RS30410 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT08_RS30415 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT08_RS30420 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT08_RS30425 ENOG4108K8U Glycerol operon regulatory protein HUT08_RS30430 ENOG4105C3R Methionine synthase HUT08_RS30435 ENOG4107URF beta-phospho-glucomutase HUT08_RS30440 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT08_RS30450 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS30480 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT08_RS30485 ENOG4105E5F proteasome HUT08_RS30490 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT08_RS30495 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT08_RS30515 ENOG4105ETE Transcriptional regulator (LacI family HUT08_RS30525 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT08_RS30530 ENOG4108V1T peptidylprolyl cis-trans isomerase HUT08_RS30560 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT08_RS30565 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUT08_RS30585 ENOG4105HFS 5'-3' exonuclease HUT08_RS30590 ENOG4108IJ7 Glycine betaine HUT08_RS30625 ENOG4108Z86 Glutamine amidotransferase HUT08_RS30630 ENOG4105CUB amino acid HUT08_RS30645 ENOG4105C26 Dehydrogenase HUT08_RS30680 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT08_RS30695 ENOG41084BS 50S ribosomal protein L35 HUT08_RS30700 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT08_RS30705 ENOG4108RWN rrna methyltransferase HUT08_RS30710 ENOG4105BZU Histidine kinase HUT08_RS30715 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT08_RS30720 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT08_RS30735 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT08_RS30775 ENOG4105F32 YngK protein HUT08_RS30785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS30800 ENOG4105E9K Isocitrate dehydrogenase HUT08_RS30805 ENOG4105N14 lysine exporter protein LysE YggA HUT08_RS30830 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT08_RS30835 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT08_RS30840 ENOG4105CAS nag kinase HUT08_RS30845 ENOG4105C8Y Acetylornithine aminotransferase HUT08_RS30850 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUT08_RS30870 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT08_RS30925 ENOG4105CDH Citrulline--aspartate ligase HUT08_RS30930 ENOG4105CH7 arginosuccinase HUT08_RS30935 ENOG4105RJZ Transcriptional regulator HUT08_RS30940 ENOG4105C57 major facilitator superfamily HUT08_RS30960 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS30965 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HUT08_RS31000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT08_RS31005 ENOG4108UMI ABC transporter, permease HUT08_RS31010 ENOG4105D01 (LipO)protein HUT08_RS31025 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT08_RS31030 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT08_RS31035 ENOG4105FCS tRNA rRNA methyltransferase HUT08_RS31040 ENOG4108762 serine threonine protein kinase HUT08_RS31085 ENOG4105CRQ synthase (Component I) HUT08_RS31095 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT08_RS31120 ENOG4105KF0 sporulation and cell division protein, SsgA HUT08_RS31150 ENOG4105C22 threonyL-tRNA synthetase HUT08_RS31175 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT08_RS31180 ENOG4105E2K Glycosyl transferase (Group 1 HUT08_RS31195 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT08_RS31200 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT08_RS31205 ENOG4105CDY transcriptional regulatory protein HUT08_RS31215 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT08_RS31220 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT08_RS31230 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT08_RS31235 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT08_RS31240 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT08_RS31245 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT08_RS31275 ENOG4105C99 atpase involved in dna repair HUT08_RS31280 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUT08_RS31290 ENOG4105CUT histidyl-tRNA synthetase HUT08_RS31310 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT08_RS31330 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT08_RS31335 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT08_RS31350 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT08_RS31355 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT08_RS31360 ENOG4105D49 3-dehydroquinate synthase HUT08_RS31365 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT08_RS31375 ENOG4105DC7 peptidase M24 HUT08_RS31380 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT08_RS31385 ENOG410803B Involved in the transcription termination process (By similarity) HUT08_RS31395 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT08_RS31400 ENOG4105CXT aspartate transcarbamylase HUT08_RS31405 ENOG4105CD3 dihydroorotase HUT08_RS31415 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT08_RS31420 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT08_RS31425 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT08_RS31430 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT08_RS31455 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT08_RS31470 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT08_RS31495 ENOG4105DJV ribulose-phosphate 3-epimerase HUT08_RS31500 ENOG4105DKT Transcriptional regulator HUT08_RS31530 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT08_RS31595 ENOG4105C2W permease HUT08_RS31600 ENOG4106UW1 Major Facilitator superfamily HUT08_RS31605 ENOG4105E2R ROK family HUT08_RS31640 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT08_RS31645 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT08_RS31650 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT08_RS31655 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT08_RS31710 ENOG4105CUB amino acid HUT08_RS31720 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT08_RS31750 ENOG41062IR nudix hydrolase HUT08_RS31755 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT08_RS31765 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS31770 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HUT08_RS31815 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT08_RS31860 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT08_RS31870 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT08_RS31925 ENOG4105D8V Glucose sorbosone dehydrogenase HUT08_RS31935 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HUT08_RS31940 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HUT08_RS31955 ENOG4108PSK reductase HUT08_RS31970 ENOG4105DIK (ABC) transporter HUT08_RS31975 ENOG4105CC5 ABC transporter HUT08_RS31995 ENOG4105KDC 50s ribosomal protein l28 HUT08_RS32000 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT08_RS32005 ENOG4105CKI cobalamin synthesis protein HUT08_RS32010 ENOG41068HZ 50S ribosomal protein L32 HUT08_RS32070 ENOG4105CHR reductase HUT08_RS32100 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT08_RS32120 ENOG4107TPY serine threonine protein kinase HUT08_RS32135 ENOG4105BZ1 (ABC) transporter HUT08_RS32145 ENOG4108MES Periplasmic binding protein HUT08_RS32150 ENOG4105E0A ABC, transporter HUT08_RS32155 ENOG4105TVJ transport system, permease HUT08_RS32160 ENOG4105DQ5 transport system permease protein HUT08_RS32175 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT08_RS32195 ENOG4105CH6 catalase HUT08_RS32210 ENOG4105EBR Carboxylesterase HUT08_RS32230 ENOG410825M Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT08_RS32310 ENOG4105KV4 Transcriptional regulator HUT08_RS32400 ENOG4108S01 response regulator HUT08_RS32435 ENOG4105VEQ Cold shock protein HUT08_RS32440 ENOG4105C1J atp-dependent rna helicase HUT08_RS32475 ENOG4107QYG anthranilate phosphoribosyltransferase HUT08_RS32480 ENOG4108I0Q anthranilate phosphoribosyltransferase HUT08_RS32500 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT08_RS32510 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS32525 ENOG4107RA9 decarboxylase HUT08_RS32535 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT08_RS32545 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT08_RS32550 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT08_RS32555 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT08_RS32590 ENOG4105EUB pirin domain protein HUT08_RS32595 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT08_RS32615 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT08_RS32630 ENOG4105C5W Aldolase HUT08_RS32635 ENOG4105E9Q Acyl-transferase HUT08_RS32655 ENOG4105C10 Electron transfer flavoprotein HUT08_RS32675 ENOG41060NJ transcriptional regulator HUT08_RS32685 ENOG4105D9P serine threonine protein kinase HUT08_RS32690 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT08_RS32710 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUT08_RS32725 ENOG4105BZU Histidine kinase HUT08_RS32730 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS32750 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT08_RS32795 ENOG4105MVE transcriptional regulator HUT08_RS32805 ENOG4106F1P AAA ATPase, central domain protein HUT08_RS32840 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HUT08_RS32870 ENOG4105FB9 CRISPR-associated protein HUT08_RS32890 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HUT08_RS32895 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HUT08_RS32945 ENOG4105CHR reductase HUT08_RS32975 ENOG4106A3M Cytochrome p-450 HUT08_RS33225 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT08_RS33315 ENOG4105K4H Nlp p60 protein HUT08_RS33345 ENOG4105JZI cytochrome P450 HUT08_RS33370 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS33385 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS33425 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT08_RS33430 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT08_RS33445 ENOG4105D0M Protease HtpX homolog HUT08_RS33480 ENOG4105DQ5 transport system permease protein HUT08_RS33485 ENOG4105TVJ transport system, permease HUT08_RS33525 ENOG4105BZ1 (ABC) transporter HUT08_RS33530 ENOG4105BZ1 (ABC) transporter HUT08_RS33540 ENOG4105VDH Dihydroxyacetone kinase HUT08_RS33545 ENOG4108UTZ Dihydroxyacetone kinase HUT08_RS33550 ENOG4105CMT Dihydroxyacetone kinase HUT08_RS33565 ENOG4105ECQ AraC Family Transcriptional Regulator HUT08_RS33590 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT08_RS33595 ENOG4107YBY Hydrolase HUT08_RS33620 ENOG4105CHJ isochorismatase hydrolase HUT08_RS33630 ENOG4108DT4 serine threonine protein kinase HUT08_RS33635 ENOG410905P Pyridoxamine 5-phosphate HUT08_RS33715 ENOG4108MJN Glycosyl Transferase HUT08_RS33740 ENOG4107R7A Allophanate hydrolase subunit 2 HUT08_RS33745 ENOG4105P4J Allophanate hydrolase, subunit 1 HUT08_RS33750 ENOG4105E7W lamb ycsf family protein HUT08_RS33770 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HUT08_RS33800 ENOG4105GWZ Roadblock lc7 family protein HUT08_RS33815 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT08_RS33825 ENOG4108UQS dipeptidase HUT08_RS33835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT08_RS33905 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT08_RS33915 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT08_RS33940 ENOG4107TIF Phenazine biosynthesis protein, PhzF family HUT08_RS33985 ENOG4105CSW GntR family transcriptional regulator HUT08_RS33990 ENOG4108Q5Y Membrane HUT08_RS34040 ENOG4108JU3 Alkyl hydroperoxide reductase HUT08_RS34075 ENOG4105C26 Dehydrogenase HUT08_RS34085 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT08_RS34130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT08_RS34140 ENOG4105CXK mandelate racemase muconate lactonizing HUT08_RS34220 ENOG4106A3M Cytochrome p-450 HUT08_RS34225 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HUT08_RS34250 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT08_RS34300 ENOG4105CVN desaturase HUT08_RS34350 ENOG4105CHR reductase HUT08_RS34355 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT08_RS34370 ENOG4105EP9 oxidoreductase HUT08_RS34375 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HUT08_RS34390 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT08_RS34400 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT08_RS34425 ENOG4108RWP Major Facilitator Superfamily protein HUT08_RS34450 ENOG4108UW5 maltose o-acetyltransferase HUT08_RS34465 ENOG4105K4P CoA-binding domain protein HUT08_RS34470 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUT08_RS34480 ENOG4105EYH Exonuclease HUT08_RS34500 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS34515 ENOG4106HB6 Alpha beta hydrolase HUT08_RS34525 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT08_RS34560 ENOG4105FDP GntR family transcriptional regulator HUT08_RS34565 ENOG4105DKQ ROK family HUT08_RS34570 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS34575 ENOG4105BZU Histidine kinase HUT08_RS34590 ENOG4108VCA G U mismatch-specific DNA glycosylase HUT08_RS34595 ENOG4105C83 adenylosuccinate lyase HUT08_RS34620 ENOG4105FBW Monooxygenase HUT08_RS34625 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT08_RS34665 ENOG4105PDP Short chain dehydrogenase HUT08_RS34670 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT08_RS34675 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT08_RS34680 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT08_RS34685 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT08_RS34695 ENOG4105K4H Nlp p60 protein HUT08_RS34755 ENOG4105CTQ phosphohexokinase HUT08_RS34760 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT08_RS34770 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT08_RS34780 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS34790 ENOG4105DQE DNA ligase HUT08_RS34795 ENOG4105NCW Trka-c domain protein HUT08_RS34820 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT08_RS34830 ENOG4105NGS secreted protein HUT08_RS34850 ENOG4105C7W Xanthine dehydrogenase HUT08_RS34855 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT08_RS34860 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT08_RS34880 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT08_RS34885 ENOG4105CPQ Dehydrogenase HUT08_RS34890 ENOG4106NZI LysR family Transcriptional regulator HUT08_RS34900 ENOG4107ETC gas vesicle protein HUT08_RS34910 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HUT08_RS34925 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HUT08_RS34940 ENOG4105ECQ AraC Family Transcriptional Regulator HUT08_RS34945 ENOG41082W1 Cupin 2, conserved barrel domain protein HUT08_RS34990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT08_RS35000 ENOG4105NPE arsR family transcriptional regulator HUT08_RS35030 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT08_RS35035 ENOG4108UZX fmn reductase HUT08_RS35065 ENOG4108JA1 polyketide synthase HUT08_RS35070 ENOG4105CEY Amp-dependent synthetase and ligase HUT08_RS35085 ENOG4105F0K SARP family transcriptional regulator HUT08_RS35115 ENOG4107QI1 Mate efflux family protein HUT08_RS35120 ENOG4108K8S endonuclease I HUT08_RS35150 ENOG4107RSM transcriptional regulator HUT08_RS35170 ENOG4105K5B UPF0225 protein HUT08_RS35195 ENOG4107HP6 Transcriptional regulator HUT08_RS35200 ENOG4105MSY salicylate hydroxylase HUT08_RS35215 ENOG4105F0K SARP family transcriptional regulator HUT08_RS35270 ENOG4108XEP Alpha Beta Hydrolase Fold protein HUT08_RS35315 ENOG4105X1P Steroid delta-isomerase HUT08_RS35385 ENOG4105CQF Transcriptional regulator HUT08_RS35390 ENOG4105EFZ amidohydrolase HUT08_RS35420 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT08_RS35425 ENOG4108S8N class II Aldolase HUT08_RS35430 ENOG4105C1G acyl-Coa dehydrogenase HUT08_RS35440 ENOG4108ZJ4 polysaccharide deacetylase HUT08_RS35465 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT08_RS35475 ENOG4105F2Z 3-oxoadipate enol-lactonase HUT08_RS35485 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HUT08_RS35495 ENOG4105CHU acetyl-coa acetyltransferase HUT08_RS35510 ENOG4107HP6 Transcriptional regulator HUT08_RS35520 ENOG4105FP9 thiamine pyrophosphate HUT08_RS35530 ENOG4105EFZ amidohydrolase HUT08_RS35565 ENOG4105ERH Fumarylacetoacetate hydrolase HUT08_RS35570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT08_RS35575 ENOG4105C26 Dehydrogenase HUT08_RS35585 ENOG4105C2C drug resistance transporter, Bcr CflA HUT08_RS35595 ENOG4105CPC Aldo Keto reductase HUT08_RS35620 ENOG4105WH1 Two component transcriptional regulator luxr family HUT08_RS35625 ENOG4108R85 Short chain dehydrogenase HUT08_RS35640 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT08_RS35650 ENOG4105C3U ABC transporter HUT08_RS35655 ENOG4108JQ6 ABC transporter HUT08_RS35665 ENOG4105C26 Dehydrogenase HUT08_RS35680 ENOG4105C5F glutamine synthetase HUT08_RS35695 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) HUT08_RS35710 ENOG4105ERH Fumarylacetoacetate hydrolase HUT08_RS35715 ENOG4108X07 Tetr family transcriptional regulator HUT08_RS35720 ENOG4105C26 Dehydrogenase HUT08_RS35725 ENOG4108Z86 Glutamine amidotransferase HUT08_RS35730 ENOG4105GVJ transcriptional regulator HUT08_RS35740 ENOG4105CHF Glutathione S-transferase HUT08_RS35770 ENOG4108WFR AraC Family Transcriptional Regulator HUT08_RS35775 ENOG4105CHR reductase HUT08_RS35785 ENOG4105CSH Transporter HUT08_RS35815 ENOG4105J7D transcriptional regulator HUT08_RS35820 ENOG4106KE4 Dehydrogenase HUT08_RS35830 ENOG4105CSH Transporter HUT08_RS35865 ENOG41067TZ transcriptional regulator, MarR family HUT08_RS35880 ENOG4105DY8 decarboxylase HUT08_RS35885 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT08_RS35895 ENOG4108Z86 Glutamine amidotransferase HUT08_RS36210 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUT08_RS36215 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT08_RS36275 ENOG4107QPD alcohol dehydrogenase HUT08_RS36280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT08_RS36320 ENOG4105DXX methyltransferase HUT08_RS36345 ENOG4105BZ1 (ABC) transporter HUT08_RS36350 ENOG4105BZ1 (ABC) transporter HUT08_RS36385 ENOG4105MP0 transposase HUT08_RS36390 ENOG4105DQ6 Transposase