locus-tag class description HUT14_RS00010 ENOG4108FPN Integrase HUT14_RS00050 ENOG4108Z6Z Transcriptional regulator HUT14_RS00130 ENOG4108XNA Gas vesicle HUT14_RS00170 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS00175 ENOG4108ZGX Histidine kinase HUT14_RS00210 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT14_RS00215 ENOG41086D8 Transcriptional regulator HUT14_RS00250 ENOG4108R5S membrane HUT14_RS00260 ENOG4108KPJ rna polymerase sigma factor HUT14_RS00270 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS00275 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUT14_RS00300 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT14_RS00310 ENOG4105EU0 Major facilitator Superfamily HUT14_RS00330 ENOG4105DSG hydrolase family 43 HUT14_RS00370 ENOG4107SCK Monooxygenase HUT14_RS00435 ENOG4107TPY serine threonine protein kinase HUT14_RS00515 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT14_RS00525 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS00535 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS00545 ENOG4105WQT MbtH domain protein HUT14_RS00555 ENOG4105EC3 peptidase S51, dipeptidase E HUT14_RS00565 ENOG4108S01 response regulator HUT14_RS00590 ENOG4106A3M Cytochrome p-450 HUT14_RS00605 ENOG4105EYF MMPL domain protein HUT14_RS00655 ENOG4105CSH Transporter HUT14_RS00660 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HUT14_RS00710 ENOG4105NAF rna polymerase sigma factor HUT14_RS00720 ENOG4105F27 Major Facilitator HUT14_RS00725 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT14_RS00740 ENOG4105ECQ AraC Family Transcriptional Regulator HUT14_RS00795 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT14_RS00805 ENOG4108MP6 LysR family Transcriptional regulator HUT14_RS00810 ENOG4105EQK -acetyltransferase HUT14_RS00815 ENOG410829K Lysine exporter protein (Lyse ygga) HUT14_RS00875 ENOG4105WN5 stage II sporulation protein HUT14_RS00880 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT14_RS00885 ENOG4107QRI Phosphoketolase HUT14_RS00910 ENOG4105E4C Lytic transglycosylase catalytic HUT14_RS00920 ENOG410832A alpha/beta hydrolase fold HUT14_RS00960 ENOG4105C0I Conserved Protein HUT14_RS00965 ENOG4105CAQ asparagine synthetase HUT14_RS00985 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT14_RS00990 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUT14_RS01020 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS01025 ENOG4105CYP glycoside hydrolase, family HUT14_RS01040 ENOG4105E6M Sulphatase-modifying factor protein HUT14_RS01065 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT14_RS01095 ENOG4105C5Y PTS System HUT14_RS01100 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT14_RS01115 ENOG4108IUE nitrate reductase beta subunit HUT14_RS01160 ENOG4105E39 Enoyl-CoA hydratase HUT14_RS01210 ENOG4107WUB V-type ATPase 116 kDa subunit HUT14_RS01230 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) HUT14_RS01235 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) HUT14_RS01250 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUT14_RS01265 ENOG4105EUB pirin domain protein HUT14_RS01270 ENOG4105DDN Pentapeptide repeat-containing protein HUT14_RS01275 ENOG4105C7W Xanthine dehydrogenase HUT14_RS01280 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT14_RS01325 ENOG4105DPX Hydrogenase, large subunit HUT14_RS01355 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HUT14_RS01375 ENOG4105CQS hydrogenase expression formation protein HypD HUT14_RS01380 ENOG4105C45 hydrogenase expression formation protein (HypE) HUT14_RS01450 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUT14_RS01460 ENOG4105CBD Diacylglycerol kinase HUT14_RS01520 ENOG4108JQ1 Dehydrogenase HUT14_RS01525 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT14_RS01530 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT14_RS01550 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HUT14_RS01580 ENOG4105CSA Coproporphyrinogen iii oxidase HUT14_RS01670 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS01675 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT14_RS01680 ENOG4105C2J ABC transporter HUT14_RS01685 ENOG4107R9N ABC transporter HUT14_RS01690 ENOG4105CNN ABC, transporter HUT14_RS01720 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT14_RS01770 ENOG4105Q56 cytochrome P450 HUT14_RS01780 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HUT14_RS01790 ENOG4105CHP RNA polymerase HUT14_RS01795 ENOG4105GRZ Ycii-related protein HUT14_RS01800 ENOG4108IG5 Transcriptional regulator HUT14_RS01805 ENOG4107QNJ CoA-transferase subunit B HUT14_RS01815 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS01840 ENOG4105J4Q Transcriptional regulator HUT14_RS01865 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HUT14_RS01870 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT14_RS01880 ENOG4108VGI doxx family HUT14_RS01925 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT14_RS01935 ENOG4108JE9 extracellular solute-binding protein family 1 HUT14_RS01940 ENOG4105CJQ hydrolase, family 31 HUT14_RS01945 ENOG4105CSR polyphosphate kinase 2 HUT14_RS01950 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUT14_RS01980 ENOG4105C4C beta-galactosidase HUT14_RS01990 ENOG4108UW5 maltose o-acetyltransferase HUT14_RS02000 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUT14_RS02015 ENOG4108U1V ABC transporter, permease HUT14_RS02020 ENOG4105J76 Periplasmic binding protein HUT14_RS02025 ENOG4105E0A ABC, transporter HUT14_RS02045 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT14_RS02065 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT14_RS02080 ENOG4106T9R serine protease HUT14_RS02090 ENOG4105CPC Aldo Keto reductase HUT14_RS02110 ENOG4105C32 Amino acid ABC transporter (Permease) HUT14_RS02115 ENOG4105C0Z ABC transporter HUT14_RS02120 ENOG4108IV0 ABC, transporter HUT14_RS02125 ENOG4105G9B Transcriptional regulator HUT14_RS02160 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT14_RS02190 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT14_RS02215 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT14_RS02285 ENOG4105BZ1 (ABC) transporter HUT14_RS02290 ENOG4108FN7 Aldo keto reductase HUT14_RS02325 ENOG4105C71 hydrolase family 65, central catalytic HUT14_RS02375 ENOG41067SE Tetr family transcriptional regulator HUT14_RS02395 ENOG4105C87 Aminotransferase class I and II HUT14_RS02415 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT14_RS02420 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HUT14_RS02480 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT14_RS02505 ENOG4108JJA ABC, transporter HUT14_RS02535 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT14_RS02560 ENOG4105DMF Dehydrogenase HUT14_RS02595 ENOG4105CPC Aldo Keto reductase HUT14_RS02615 ENOG4105CHF Glutathione S-transferase HUT14_RS02650 ENOG4105DCG PHP domain protein HUT14_RS02665 ENOG4105CMR udp-glucose 4-epimerase HUT14_RS02695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUT14_RS02705 ENOG4108R86 Transcriptional regulator HUT14_RS02710 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUT14_RS02715 ENOG4108KPJ rna polymerase sigma factor HUT14_RS02730 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS02740 ENOG4105D4B ABC, transporter HUT14_RS02745 ENOG4105F5R ABC transporter HUT14_RS02750 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT14_RS02755 ENOG4105C2J ABC transporter HUT14_RS02760 ENOG4105C9F isomerase HUT14_RS02770 ENOG4105DET Rhamnulokinase HUT14_RS02775 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT14_RS02780 ENOG4107QR9 Iron-sulfur cluster binding protein HUT14_RS02785 ENOG41080R8 Conserved Protein HUT14_RS02790 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT14_RS02800 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB HUT14_RS02855 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT14_RS02865 ENOG41080RH Thioredoxin HUT14_RS02870 ENOG41060NJ transcriptional regulator HUT14_RS02890 ENOG4105C7W Xanthine dehydrogenase HUT14_RS02895 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT14_RS02900 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT14_RS02910 ENOG4107RSM transcriptional regulator HUT14_RS02920 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT14_RS02935 ENOG4108V1U phospholipid-binding protein HUT14_RS02955 ENOG4105GTG Isochorismatase HUT14_RS02985 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT14_RS02990 ENOG4108V75 Glutamine amidotransferase HUT14_RS02995 ENOG41067HS methyltransferase HUT14_RS03005 ENOG4105WKW Pfam:DUF1458 HUT14_RS03015 ENOG4107KM7 Heat induced stress protein YflT HUT14_RS03020 ENOG4108Z20 Acyl-transferase HUT14_RS03030 ENOG4105E33 succinate dehydrogenase HUT14_RS03045 ENOG4105C5Q Transcriptional regulator HUT14_RS03055 ENOG4108ZJ4 polysaccharide deacetylase HUT14_RS03090 ENOG4105BZU Histidine kinase HUT14_RS03165 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT14_RS03170 ENOG4107QPH glycogen) synthase HUT14_RS03190 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT14_RS03205 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT14_RS03260 ENOG4105ERH Fumarylacetoacetate hydrolase HUT14_RS03265 ENOG4105DIA mandelate racemase muconate lactonizing HUT14_RS03290 ENOG4105CQB FAD linked oxidase domain protein HUT14_RS03300 ENOG4105DIA mandelate racemase muconate lactonizing HUT14_RS03310 ENOG4108W6C Dehydrogenase HUT14_RS03315 ENOG4105CH6 catalase HUT14_RS03325 ENOG4105C1J atp-dependent rna helicase HUT14_RS03330 ENOG4105BZ1 (ABC) transporter HUT14_RS03335 ENOG4105EN6 Membrane HUT14_RS03340 ENOG4105CH2 amidohydrolase HUT14_RS03345 ENOG4108KPJ rna polymerase sigma factor HUT14_RS03380 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT14_RS03400 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT14_RS03405 ENOG4105XN3 extracellular solute-binding protein family 1 HUT14_RS03410 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS03420 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT14_RS03435 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS03455 ENOG4107T94 Endo-14-beta-xylanase HUT14_RS03485 ENOG4105BZU Histidine kinase HUT14_RS03490 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS03500 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT14_RS03505 ENOG4105BZ1 (ABC) transporter HUT14_RS03515 ENOG4105D64 Mechanosensitive ion channel HUT14_RS03520 ENOG4105E9K Isocitrate dehydrogenase HUT14_RS03565 ENOG4105D2S major facilitator superfamily HUT14_RS03580 ENOG4105JSC dimethylmenaquinone methyltransferase HUT14_RS03595 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT14_RS03600 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS03610 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT14_RS03620 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT14_RS03625 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HUT14_RS03630 ENOG4105C2J ABC transporter HUT14_RS03635 ENOG4105CNN ABC, transporter HUT14_RS03645 ENOG4105EDK PfkB domain protein HUT14_RS03655 ENOG4105DH8 myo-inositol catabolism HUT14_RS03660 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUT14_RS03665 ENOG4105FDP GntR family transcriptional regulator HUT14_RS03780 ENOG4108IG5 Transcriptional regulator HUT14_RS03795 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT14_RS03805 ENOG4105D2N Aldolase HUT14_RS03815 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT14_RS03835 ENOG4105E98 transcriptional regulator DeoR family HUT14_RS03845 ENOG4105EPC oxidoreductase HUT14_RS03885 ENOG4107RRZ synthase HUT14_RS03915 ENOG4105MVE transcriptional regulator HUT14_RS03945 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT14_RS03950 ENOG4105DKQ ROK family HUT14_RS03960 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HUT14_RS03975 ENOG4105BZP glycoside hydrolase 15-related HUT14_RS04000 ENOG4105CK5 oxidoreductase HUT14_RS04025 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT14_RS04050 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS04055 ENOG4105BZU Histidine kinase HUT14_RS04070 ENOG4105I1F Resistance protein HUT14_RS04085 ENOG41060NJ transcriptional regulator HUT14_RS04105 ENOG4105C10 Electron transfer flavoprotein HUT14_RS04125 ENOG4105E9Q Acyl-transferase HUT14_RS04155 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT14_RS04190 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT14_RS04195 ENOG4105M4P Tetr family transcriptional regulator HUT14_RS04220 ENOG4105YVS arsR family transcriptional regulator HUT14_RS04225 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT14_RS04240 ENOG4105CSU acyl-Coa dehydrogenase HUT14_RS04250 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT14_RS04275 ENOG4107VXZ Hydrolase HUT14_RS04320 ENOG4108YV4 Universal stress protein HUT14_RS04340 ENOG4105BZU Histidine kinase HUT14_RS04365 ENOG4105C0D helicase HUT14_RS04390 ENOG4107ZED Uncharacterised protein family UPF0047 HUT14_RS04395 ENOG4105F95 Monooxygenase HUT14_RS04400 ENOG4105HHA aminodeoxychorismate lyase HUT14_RS04405 ENOG4105BZ1 (ABC) transporter HUT14_RS04415 ENOG4105BZ1 (ABC) transporter HUT14_RS04420 ENOG4105BZ1 (ABC) transporter HUT14_RS04445 ENOG4105C29 acyl-CoA thioesterase HUT14_RS04455 ENOG4105GWZ Roadblock lc7 family protein HUT14_RS04495 ENOG4105C0D helicase HUT14_RS04540 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS04545 ENOG4105D2B acyl-CoA dehydrogenase HUT14_RS04550 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT14_RS04565 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HUT14_RS04575 ENOG4105C26 Dehydrogenase HUT14_RS04590 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS04600 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT14_RS04605 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT14_RS04610 ENOG4105F1K Glutamine amidotransferase HUT14_RS04615 ENOG4105CTQ phosphohexokinase HUT14_RS04635 ENOG4108HRK Histidine kinase HUT14_RS04640 ENOG4107QN1 sodium solute HUT14_RS04650 ENOG4105DY9 regulatoR HUT14_RS04660 ENOG4105CIK Amidinotransferase HUT14_RS04665 ENOG4105C8Y Acetylornithine aminotransferase HUT14_RS04680 ENOG4108YZG isomerase HUT14_RS04685 ENOG4105F6E Acyl-transferase HUT14_RS04700 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT14_RS04710 ENOG4105CQM Urea amidohydrolase subunit alpha HUT14_RS04715 ENOG4105KI2 Urea amidohydrolase subunit beta HUT14_RS04720 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUT14_RS04765 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT14_RS04770 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT14_RS04775 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT14_RS04795 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT14_RS04800 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT14_RS04820 ENOG4105C83 adenylosuccinate lyase HUT14_RS04825 ENOG4108VCA G U mismatch-specific DNA glycosylase HUT14_RS04845 ENOG4105BZU Histidine kinase HUT14_RS04850 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS04855 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HUT14_RS04860 ENOG4105FDP GntR family transcriptional regulator HUT14_RS04865 ENOG4108KPJ rna polymerase sigma factor HUT14_RS04875 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT14_RS04915 ENOG4105EYH Exonuclease HUT14_RS04920 ENOG4107RH8 nuclease SbcCD subunit D HUT14_RS04925 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUT14_RS04935 ENOG4105C8N cysteinyl-tRNA synthetase HUT14_RS04940 ENOG4105K4P CoA-binding domain protein HUT14_RS04945 ENOG41082SX arsR family transcriptional regulator HUT14_RS04970 ENOG4108UW5 maltose o-acetyltransferase HUT14_RS04975 ENOG4108Z0R Transferase HUT14_RS05005 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT14_RS05020 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT14_RS05030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT14_RS05045 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HUT14_RS05050 ENOG4105EP9 oxidoreductase HUT14_RS05070 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT14_RS05080 ENOG4105CHR reductase HUT14_RS05130 ENOG4105JQN Transcriptional regulator HUT14_RS05135 ENOG4108Q5Y Membrane HUT14_RS05140 ENOG4105CSW GntR family transcriptional regulator HUT14_RS05170 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT14_RS05195 ENOG4105KVH Transcriptional regulator HUT14_RS05210 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HUT14_RS05225 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT14_RS05235 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT14_RS05255 ENOG4108UW8 fha domain-containing protein HUT14_RS05300 ENOG4105C5Y PTS System HUT14_RS05305 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT14_RS05315 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT14_RS05330 ENOG4108UQS dipeptidase HUT14_RS05350 ENOG4105GWZ Roadblock lc7 family protein HUT14_RS05395 ENOG4105CFM UPF0317 protein HUT14_RS05400 ENOG4105E7W lamb ycsf family protein HUT14_RS05405 ENOG4105P4J Allophanate hydrolase, subunit 1 HUT14_RS05420 ENOG4108MJN Glycosyl Transferase HUT14_RS05435 ENOG4105JXB ankyrin repeat-containing protein HUT14_RS05455 ENOG4108VW9 Membrane HUT14_RS05465 ENOG4105DEU major facilitator superfamily HUT14_RS05470 ENOG4105Q70 HUT14_RS05475 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HUT14_RS05480 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT14_RS05490 ENOG4105EW9 transcriptional regulator AsnC family HUT14_RS05505 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS05555 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT14_RS05560 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT14_RS05565 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT14_RS05570 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT14_RS05585 ENOG4105ECP epimerase HUT14_RS05590 ENOG4105E2R ROK family HUT14_RS05595 ENOG4106UW1 Major Facilitator superfamily HUT14_RS05605 ENOG4105C2W permease HUT14_RS05640 ENOG4105CUB amino acid HUT14_RS05655 ENOG4105DKT Transcriptional regulator HUT14_RS05660 ENOG4105DJV ribulose-phosphate 3-epimerase HUT14_RS05665 ENOG4105EYF MMPL domain protein HUT14_RS05675 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT14_RS05690 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT14_RS05700 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT14_RS05705 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUT14_RS05715 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT14_RS05720 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT14_RS05725 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT14_RS05730 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT14_RS05740 ENOG4105CD3 dihydroorotase HUT14_RS05745 ENOG4105CXT aspartate transcarbamylase HUT14_RS05750 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT14_RS05760 ENOG410803B Involved in the transcription termination process (By similarity) HUT14_RS05765 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT14_RS05770 ENOG4105DC7 peptidase M24 HUT14_RS05780 ENOG4105D49 3-dehydroquinate synthase HUT14_RS05785 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT14_RS05790 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT14_RS05800 ENOG4105E2X shikimate dehydrogenase HUT14_RS05810 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT14_RS05815 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT14_RS05830 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT14_RS05845 ENOG4105CUT histidyl-tRNA synthetase HUT14_RS05855 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUT14_RS05860 ENOG4105C99 atpase involved in dna repair HUT14_RS05865 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT14_RS05870 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT14_RS05875 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT14_RS05880 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT14_RS05890 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT14_RS05895 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT14_RS05900 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUT14_RS05905 ENOG4105CDY transcriptional regulatory protein HUT14_RS05910 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT14_RS05915 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT14_RS05925 ENOG4105E2K Glycosyl transferase (Group 1 HUT14_RS05930 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT14_RS05955 ENOG4105C22 threonyL-tRNA synthetase HUT14_RS05970 ENOG4108IRC dna polymerase iii HUT14_RS05985 ENOG4105EKC HUT14_RS05995 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT14_RS06000 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT14_RS06020 ENOG4105KF0 sporulation and cell division protein, SsgA HUT14_RS06050 ENOG4105F0I Aminotransferase HUT14_RS06055 ENOG4105CRQ synthase (Component I) HUT14_RS06115 ENOG4108IJ6 ABC transporter HUT14_RS06125 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT14_RS06205 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT14_RS06220 ENOG4107XVH Transcriptional regulator HUT14_RS06230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT14_RS06235 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT14_RS06250 ENOG4105D01 (LipO)protein HUT14_RS06255 ENOG4108UMI ABC transporter, permease HUT14_RS06260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT14_RS06290 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HUT14_RS06295 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS06300 ENOG4105C57 major facilitator superfamily HUT14_RS06305 ENOG4105RJZ Transcriptional regulator HUT14_RS06315 ENOG4105CH7 arginosuccinase HUT14_RS06320 ENOG4105CDH Citrulline--aspartate ligase HUT14_RS06355 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUT14_RS06360 ENOG4105C8Y Acetylornithine aminotransferase HUT14_RS06365 ENOG4105CAS nag kinase HUT14_RS06370 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT14_RS06375 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT14_RS06385 ENOG4108VGI doxx family HUT14_RS06415 ENOG4105T38 integral membrane protein HUT14_RS06425 ENOG4105F32 YngK protein HUT14_RS06450 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT14_RS06455 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT14_RS06460 ENOG4105BZU Histidine kinase HUT14_RS06465 ENOG4108RWN rrna methyltransferase HUT14_RS06470 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT14_RS06475 ENOG41084BS 50S ribosomal protein L35 HUT14_RS06480 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUT14_RS06525 ENOG4105C26 Dehydrogenase HUT14_RS06530 ENOG4105C5F glutamine synthetase HUT14_RS06540 ENOG4105CUB amino acid HUT14_RS06545 ENOG4108Z86 Glutamine amidotransferase HUT14_RS06560 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT14_RS06570 ENOG4108HQS Glycine betaine HUT14_RS06575 ENOG4108IJ7 Glycine betaine HUT14_RS06580 ENOG4105HFS 5'-3' exonuclease HUT14_RS06595 ENOG4105D3G Pseudouridine synthase HUT14_RS06635 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUT14_RS06640 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT14_RS06660 ENOG4108FFZ Transcriptional regulator HUT14_RS06670 ENOG4108V1T peptidylprolyl cis-trans isomerase HUT14_RS06675 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT14_RS06685 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS06690 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT14_RS06695 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT14_RS06705 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT14_RS06710 ENOG4105E5F proteasome HUT14_RS06715 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT14_RS06745 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS06750 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT14_RS06755 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HUT14_RS06760 ENOG4105C3R Methionine synthase HUT14_RS06765 ENOG4108K8U Glycerol operon regulatory protein HUT14_RS06770 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT14_RS06775 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT14_RS06780 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT14_RS06785 ENOG4105JXH GntR family transcriptional regulator HUT14_RS06795 ENOG4105C8N cysteinyl-tRNA synthetase HUT14_RS06810 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT14_RS06815 ENOG4105D7N magnesium and cobalt transport protein CorA HUT14_RS06825 ENOG4105DYW oxidoreductase HUT14_RS06830 ENOG4105CPC Aldo Keto reductase HUT14_RS06850 ENOG4105S2J secreted protein HUT14_RS06860 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT14_RS06870 ENOG4105K5B UPF0225 protein HUT14_RS06875 ENOG4105C6F GntR Family Transcriptional Regulator HUT14_RS06880 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT14_RS06885 ENOG4105C6Z Gluconate HUT14_RS06910 ENOG4105PTV Nudix Hydrolase HUT14_RS06915 ENOG4105VG5 Membrane HUT14_RS06925 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT14_RS06935 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS06945 ENOG4105DUM transcriptional regulator, lysR family HUT14_RS06950 ENOG4108IG5 Transcriptional regulator HUT14_RS06960 ENOG4105EHZ conserved protein UCP016719 HUT14_RS06970 ENOG4108Z4X TRANSCRIPTIONal HUT14_RS06990 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS07000 ENOG4108ZHR arsR family transcriptional regulator HUT14_RS07025 ENOG4105D4T Citrate transporter HUT14_RS07030 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT14_RS07035 ENOG4108SGK Tetr family transcriptional regulator HUT14_RS07045 ENOG4105F1J Homogentisate 1,2-dioxygenase HUT14_RS07080 ENOG4105RNG membrane HUT14_RS07085 ENOG4105K6V RNA polymerase HUT14_RS07110 ENOG4108TCJ secreted hydrolase HUT14_RS07125 ENOG4107BJW polysaccharide deacetylase HUT14_RS07140 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT14_RS07185 ENOG4105C0B DNA polymerase III (alpha subunit) HUT14_RS07200 ENOG4106NMR serine protease HUT14_RS07210 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT14_RS07215 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS07220 ENOG4105C57 major facilitator superfamily HUT14_RS07230 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT14_RS07260 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT14_RS07270 ENOG4105CAT Cytidine monophosphate kinase HUT14_RS07290 ENOG41065RQ ADP-ribosylation crystallin J1 HUT14_RS07300 ENOG4105FE9 pseudouridine synthase HUT14_RS07305 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT14_RS07310 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUT14_RS07325 ENOG4105DCF alanine dehydrogenase HUT14_RS07335 ENOG4108YZ4 nudix hydrolase HUT14_RS07340 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT14_RS07345 ENOG4105BZP glycoside hydrolase 15-related HUT14_RS07360 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT14_RS07365 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT14_RS07385 ENOG4105E0A ABC, transporter HUT14_RS07390 ENOG4105TVJ transport system, permease HUT14_RS07395 ENOG4105DQ5 transport system permease protein HUT14_RS07400 ENOG4105DSU hydrolase HUT14_RS07430 ENOG4108VX5 3-methyladenine DNA glycosylase HUT14_RS07440 ENOG4108V1U phospholipid-binding protein HUT14_RS07460 ENOG4105DKW ABC transporter HUT14_RS07475 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS07485 ENOG4105EMU Dehydrogenase HUT14_RS07490 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HUT14_RS07500 ENOG4105IDI abc transporter atp-binding protein HUT14_RS07510 ENOG4105EAC phosphoserine phosphatase HUT14_RS07530 ENOG4107YCY Transcriptional regulator HUT14_RS07540 ENOG4105CHR reductase HUT14_RS07545 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A HUT14_RS07565 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT14_RS07585 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT14_RS07590 ENOG4107QN1 sodium solute HUT14_RS07610 ENOG410846T CoA-transferase family III HUT14_RS07620 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT14_RS07650 ENOG4105BZP glycoside hydrolase 15-related HUT14_RS07680 ENOG4105VBF alkaline shock protein HUT14_RS07690 ENOG41060WC Enoyl-CoA hydratase HUT14_RS07700 ENOG4105C5H ABC transporter HUT14_RS07720 ENOG4107W7X Aldolase HUT14_RS07735 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT14_RS07740 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT14_RS07745 ENOG4105CTK cobaltochelatase, cobn subunit HUT14_RS07755 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HUT14_RS07760 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT14_RS07775 ENOG4105CIA precorrin-4 C(11)-methyltransferase HUT14_RS07785 ENOG4105E4R Precorrin-3B C17-methyltransferase HUT14_RS07790 ENOG41081F0 Precorrin-8x methylmutase HUT14_RS07795 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HUT14_RS07820 ENOG4105EAD ABC transporter HUT14_RS07825 ENOG4106PMH Extracellular solute-binding protein family 3 HUT14_RS07830 ENOG4105C5R Aminotransferase HUT14_RS07835 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HUT14_RS07840 ENOG4108JPW Aminotransferase HUT14_RS07845 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HUT14_RS07850 ENOG4105EV8 ectoine hydroxylase HUT14_RS07855 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT14_RS07875 ENOG4105BZU Histidine kinase HUT14_RS07880 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS07890 ENOG4107HP6 Transcriptional regulator HUT14_RS07900 ENOG4105CJN penicillin-binding protein HUT14_RS07905 ENOG4105NAF rna polymerase sigma factor HUT14_RS07920 ENOG4107SYN Glycosyl hydrolases family 43 HUT14_RS07930 ENOG4105NBR Pectinesterase HUT14_RS07935 ENOG4108J20 pectate lyase HUT14_RS07940 ENOG4107TDE lipolytic protein G-D-S-L family HUT14_RS07980 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT14_RS07985 ENOG4105DRR Transcriptional regulator, GntR family HUT14_RS08010 ENOG4105E9Z Nad-dependent epimerase dehydratase HUT14_RS08015 ENOG4105E98 transcriptional regulator DeoR family HUT14_RS08035 ENOG4105CPQ Dehydrogenase HUT14_RS08080 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT14_RS08090 ENOG4105NAF rna polymerase sigma factor HUT14_RS08095 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HUT14_RS08105 ENOG4105VG1 fes assembly suf system protein HUT14_RS08110 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT14_RS08115 ENOG4105C9B Cysteine desulfurase HUT14_RS08120 ENOG4105C3K feS assembly ATPase SufC HUT14_RS08130 ENOG4105JRK feS assembly protein SufD HUT14_RS08145 ENOG4105CJ1 ABC, transporter HUT14_RS08155 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HUT14_RS08175 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT14_RS08185 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT14_RS08200 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT14_RS08205 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT14_RS08210 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HUT14_RS08220 ENOG4105CG3 alpha amylase, catalytic region HUT14_RS08225 ENOG4107T3P ABC, transporter HUT14_RS08230 ENOG4105U3E Transcriptional regulator HUT14_RS08235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT14_RS08250 ENOG4107QP8 phosphohexose isomerase HUT14_RS08265 ENOG4105CP7 Triose-phosphate isomerase HUT14_RS08270 ENOG4105BZA Phosphoglycerate kinase HUT14_RS08275 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT14_RS08285 ENOG4105CIE May be required for sporulation (By similarity) HUT14_RS08290 ENOG4105CHW UPF0052 protein HUT14_RS08295 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT14_RS08300 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT14_RS08315 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HUT14_RS08320 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS08325 ENOG4105D7K pfkb domain protein HUT14_RS08330 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT14_RS08340 ENOG4107VMB Beta-lactamase domain protein HUT14_RS08345 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT14_RS08370 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUT14_RS08375 ENOG4105BZU Histidine kinase HUT14_RS08380 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT14_RS08385 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT14_RS08395 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT14_RS08515 ENOG4105E2A Dehydrogenase HUT14_RS08525 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT14_RS08530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT14_RS08545 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT14_RS08550 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT14_RS08565 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT14_RS08575 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT14_RS08585 ENOG4105CQ7 ATP-dependent helicase HUT14_RS08615 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HUT14_RS08630 ENOG4105C32 Amino acid ABC transporter (Permease) HUT14_RS08635 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT14_RS08640 ENOG4105C0Z ABC transporter HUT14_RS08645 ENOG4108IV0 ABC, transporter HUT14_RS08670 ENOG4105CGH 5'-nucleotidase HUT14_RS08675 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT14_RS08685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS08690 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HUT14_RS08700 ENOG4105MUA Resistance protein HUT14_RS08720 ENOG4105CBC glutamate synthase HUT14_RS08730 ENOG41065RQ ADP-ribosylation crystallin J1 HUT14_RS08750 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT14_RS08755 ENOG4105CI0 Citrate lyase HUT14_RS08760 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT14_RS08770 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT14_RS08775 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT14_RS08780 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT14_RS08800 ENOG4105CRQ synthase (Component I) HUT14_RS08805 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT14_RS08820 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT14_RS08825 ENOG4108176 endoribonuclease L-psp HUT14_RS08830 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT14_RS08835 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT14_RS08845 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT14_RS08850 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT14_RS08855 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT14_RS08880 ENOG4108Z66 YbaK ebsC protein HUT14_RS08910 ENOG4105C0B DNA polymerase III (alpha subunit) HUT14_RS08970 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT14_RS08980 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT14_RS08985 ENOG4107VQS DivIVA family HUT14_RS08995 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT14_RS09000 ENOG4105DFA alanine racemase domain protein HUT14_RS09005 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUT14_RS09010 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT14_RS09015 ENOG4105ME9 cell division protein FtsQ HUT14_RS09020 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT14_RS09030 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT14_RS09035 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT14_RS09045 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT14_RS09060 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT14_RS09070 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT14_RS09105 ENOG4105ECB domain protein HUT14_RS09110 ENOG4107Z3H Transcriptional regulator, TetR family HUT14_RS09115 ENOG4105EWK phytoene HUT14_RS09130 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT14_RS09160 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT14_RS09170 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT14_RS09180 ENOG4108UQY Iron-storage protein HUT14_RS09190 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT14_RS09205 ENOG4105C5I Dehydrogenase HUT14_RS09215 ENOG4105ENE Histidine kinase HUT14_RS09240 ENOG4105DKQ ROK family HUT14_RS09250 ENOG4105D0U Arsenite-activated ATPase (ArsA) HUT14_RS09270 ENOG4105JNK Glycosyl transferase (Group 1 HUT14_RS09315 ENOG4105C9B Cysteine desulfurase HUT14_RS09320 ENOG4108I0Q anthranilate phosphoribosyltransferase HUT14_RS09325 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT14_RS09330 ENOG4107EUI c reductase, iron-sulfur HUT14_RS09335 ENOG4107UDY cytochrome C HUT14_RS09340 ENOG4105CCU oxidase (Subunit III) HUT14_RS09350 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT14_RS09355 ENOG4105MCD Part of cytochrome c oxidase, its function is HUT14_RS09360 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT14_RS09365 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT14_RS09375 ENOG4107T4Z adenosine kinase HUT14_RS09395 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT14_RS09405 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS09450 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT14_RS09460 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HUT14_RS09475 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT14_RS09495 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT14_RS09545 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT14_RS09550 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT14_RS09570 ENOG4105C5F glutamine synthetase HUT14_RS09580 ENOG4105D0M Protease HtpX homolog HUT14_RS09595 ENOG4108222 arsenate reductase HUT14_RS09600 ENOG4106SPC secreted protein HUT14_RS09605 ENOG4107R5B glutamine synthetase HUT14_RS09610 ENOG4107NHD transcriptional regulator HUT14_RS09625 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS09675 ENOG4105CG3 alpha amylase, catalytic region HUT14_RS09680 ENOG4105EG2 ABC transporter, permease HUT14_RS09685 ENOG4105D56 permease protein HUT14_RS09690 ENOG4108IJG ABC transporter substrate-binding protein HUT14_RS09695 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS09705 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT14_RS09730 ENOG4105C5F glutamine synthetase HUT14_RS09735 ENOG41081JD Transcriptional regulator HUT14_RS09750 ENOG4105C4K Nad synthetase HUT14_RS09765 ENOG4105C57 major facilitator superfamily HUT14_RS09770 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT14_RS09790 ENOG4107XZ0 Peptidase M50 HUT14_RS09830 ENOG410650H (LipO)protein HUT14_RS09835 ENOG4105DBE peroxidase HUT14_RS09845 ENOG4106A0S HUT14_RS09855 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HUT14_RS09860 ENOG4105YIP Tetr family transcriptional regulator HUT14_RS09870 ENOG4107S1E Beta-lactamase HUT14_RS09875 ENOG4105C2C drug resistance transporter, Bcr CflA HUT14_RS09895 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUT14_RS09900 ENOG4107HP6 Transcriptional regulator HUT14_RS09905 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HUT14_RS09910 ENOG4105EYF MMPL domain protein HUT14_RS09945 ENOG4105CHR reductase HUT14_RS09950 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUT14_RS09955 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUT14_RS09970 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT14_RS09975 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS09980 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT14_RS10015 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS10020 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS10035 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS10045 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS10045 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS10050 ENOG4106YKD Cytochrome p-450 HUT14_RS10065 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUT14_RS10125 ENOG4108WZM domain protein HUT14_RS10210 ENOG4107QRT dEAD DEAH box helicase HUT14_RS10215 ENOG4106A3M Cytochrome p-450 HUT14_RS10220 ENOG4106A3M Cytochrome p-450 HUT14_RS10280 ENOG4105E7U AraC family transcriptional regulator HUT14_RS10295 ENOG4107XFJ UPF0246 protein HUT14_RS10300 ENOG4108UHU Aldolase HUT14_RS10315 ENOG4105EGD dinuclear metal center protein, YbgI family HUT14_RS10335 ENOG4105BZU Histidine kinase HUT14_RS10380 ENOG4107QVI Methyltransferase, type 11 HUT14_RS10385 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT14_RS10390 ENOG4108SGK Tetr family transcriptional regulator HUT14_RS10415 ENOG4108JJB ABC transporter HUT14_RS10435 ENOG4105CSH Transporter HUT14_RS10480 ENOG4107VXZ Hydrolase HUT14_RS10540 ENOG4107T5V SNARE associated Golgi HUT14_RS10550 ENOG4105DAX Pfam:DUF2983 HUT14_RS10595 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT14_RS10625 ENOG4105VUF Transcriptional regulator HUT14_RS10640 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT14_RS10675 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT14_RS10680 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT14_RS10700 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT14_RS10705 ENOG4105NGS secreted protein HUT14_RS10710 ENOG4105N14 lysine exporter protein LysE YggA HUT14_RS10720 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT14_RS10735 ENOG4105CXK mandelate racemase muconate lactonizing HUT14_RS10750 ENOG4105DFW ABC transporter HUT14_RS10760 ENOG4108HWW ABC transporter HUT14_RS10765 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT14_RS10770 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT14_RS10775 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HUT14_RS10845 ENOG4105DHJ ABC, transporter HUT14_RS10880 ENOG4105DRS transport system, permease HUT14_RS10885 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HUT14_RS10915 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HUT14_RS10920 ENOG41069M3 Transcriptional regulator HUT14_RS10940 ENOG4105C6F GntR Family Transcriptional Regulator HUT14_RS10950 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS10955 ENOG4105D8K carboxyl transferase HUT14_RS10960 ENOG4105DFF Rod shape-determining protein mreb HUT14_RS11020 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS11025 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUT14_RS11035 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT14_RS11045 ENOG4107GZ4 SanA protein HUT14_RS11050 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT14_RS11075 ENOG4105KVH Transcriptional regulator HUT14_RS11095 ENOG4107QZF nitrite reductase NADPH large subunit HUT14_RS11100 ENOG4107QZF nitrite reductase NADPH large subunit HUT14_RS11120 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT14_RS11145 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT14_RS11150 ENOG4105DSE periplasmic solute binding protein HUT14_RS11155 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT14_RS11160 ENOG4105FAV ABC, transporter HUT14_RS11175 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT14_RS11180 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT14_RS11220 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS11225 ENOG4105BZU Histidine kinase HUT14_RS11230 ENOG4105EYF MMPL domain protein HUT14_RS11275 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT14_RS11280 ENOG4105D4Y metalloprotease HUT14_RS11295 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT14_RS11305 ENOG4105MSB protein, conserved in bacteria HUT14_RS11315 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT14_RS11325 ENOG4107UEK pfkb domain protein HUT14_RS11330 ENOG4105EQX glucarate dehydratase HUT14_RS11335 ENOG4107258 Transcriptional regulator HUT14_RS11350 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT14_RS11355 ENOG4107YU2 histidine triad (hIT) protein HUT14_RS11360 ENOG4107RE3 peptidase, S41 HUT14_RS11375 ENOG4107QWG 2-Nitropropane dioxygenase HUT14_RS11380 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT14_RS11385 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT14_RS11415 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT14_RS11420 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT14_RS11435 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUT14_RS11450 ENOG4105EPR degv family HUT14_RS11460 ENOG4105C8T Leucyl-tRNA synthetase HUT14_RS11470 ENOG4107QIZ NADH dehydrogenase HUT14_RS11495 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT14_RS11500 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HUT14_RS11510 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT14_RS11520 ENOG4105D0M Protease HtpX homolog HUT14_RS11535 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT14_RS11545 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT14_RS11575 ENOG4105DGI Alkaline phosphatase HUT14_RS11585 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT14_RS11590 ENOG4105K46 50S ribosomal protein l27 HUT14_RS11595 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT14_RS11605 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUT14_RS11615 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT14_RS11620 ENOG4105C03 ribonuclease HUT14_RS11650 ENOG4105CNI cell division protein FtsW HUT14_RS11655 ENOG4105CJN penicillin-binding protein HUT14_RS11670 ENOG4105DFF Rod shape-determining protein mreb HUT14_RS11675 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT14_RS11685 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT14_RS11695 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT14_RS11705 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT14_RS11710 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT14_RS11715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT14_RS11720 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT14_RS11740 ENOG4108TGC Acyltransferase HUT14_RS11770 ENOG4105C85 amino acid HUT14_RS11780 ENOG4105C85 amino acid HUT14_RS11790 ENOG4105MC2 DSBA oxidoreductase HUT14_RS11850 ENOG4105M4P Tetr family transcriptional regulator HUT14_RS11860 ENOG4108KTG Membrane protein, drug metabolite transporter HUT14_RS11865 ENOG4108ZT1 Transcriptional regulator HUT14_RS11885 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 HUT14_RS11895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT14_RS11910 ENOG4105D8X mechanosensitive ion channel HUT14_RS11920 ENOG4105F8D glycoside hydrolase family 4 HUT14_RS11935 ENOG4106PMH Extracellular solute-binding protein family 3 HUT14_RS11965 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT14_RS11985 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT14_RS12070 ENOG4105VHU single-stranded DNA-binding protein HUT14_RS12150 ENOG4105D3Q Sugar transferase HUT14_RS12160 ENOG4105CJR Integral membrane protein (MviN HUT14_RS12170 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT14_RS12190 ENOG4105C3M thioredoxin reductase HUT14_RS12205 ENOG4105CJ1 ABC, transporter HUT14_RS12210 ENOG4105C26 Dehydrogenase HUT14_RS12240 ENOG4105C7H Helicase, RecD TraA family HUT14_RS12300 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS12305 ENOG4105C2J ABC transporter HUT14_RS12310 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT14_RS12315 ENOG4108RVA ribokinase HUT14_RS12320 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HUT14_RS12375 ENOG4105EC2 ftsk spoIIIe HUT14_RS12400 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS12415 ENOG4108594 Permease of the drug metabolite transporter HUT14_RS12425 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT14_RS12455 ENOG4108K8S endonuclease I HUT14_RS12465 ENOG4105C7K acetolactate synthase HUT14_RS12480 ENOG4108XFF HUT14_RS12490 ENOG4105C29 acyl-CoA thioesterase HUT14_RS12505 ENOG4107QX3 carboxylase HUT14_RS12515 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT14_RS12520 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS12535 ENOG4105ESF Peptidoglycan binding domain protein HUT14_RS12560 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT14_RS12585 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT14_RS12595 ENOG4105ECQ AraC Family Transcriptional Regulator HUT14_RS12600 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUT14_RS12610 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS12625 ENOG4105DRS transport system, permease HUT14_RS12635 ENOG4108NNZ chitinase HUT14_RS12655 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT14_RS12670 ENOG4105CVJ phosphoglycerate mutase HUT14_RS12715 ENOG4105BZU Histidine kinase HUT14_RS12720 ENOG4105DEN Luciferase family HUT14_RS12735 ENOG4105C5I Dehydrogenase HUT14_RS12740 ENOG4105DV0 amidase (EC 3.5.1.4 HUT14_RS12775 ENOG4108M1A Chitin-binding protein HUT14_RS12805 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT14_RS12820 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HUT14_RS12825 ENOG4105D9R oxidoreductase HUT14_RS12830 ENOG41090KN UPF0303 protein HUT14_RS12835 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT14_RS12860 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HUT14_RS12930 ENOG410905P Pyridoxamine 5-phosphate HUT14_RS12935 ENOG4108SGK Tetr family transcriptional regulator HUT14_RS12940 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT14_RS12945 ENOG4108RFG Tetr family transcriptional regulator HUT14_RS12975 ENOG4105D2S major facilitator superfamily HUT14_RS12980 ENOG4106BRA Membrane HUT14_RS12995 ENOG4108IUW ABC transporter HUT14_RS13010 ENOG4105BZ4 penicillin-binding protein HUT14_RS13050 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT14_RS13060 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT14_RS13080 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT14_RS13105 ENOG4105C85 amino acid HUT14_RS13115 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT14_RS13125 ENOG4108RWI nicotinamidase HUT14_RS13155 ENOG4105CQB FAD linked oxidase domain protein HUT14_RS13165 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT14_RS13175 ENOG4105E90 ABC transporter HUT14_RS13180 ENOG4108IJ8 ABC transporter HUT14_RS13185 ENOG4105E90 ABC transporter HUT14_RS13190 ENOG4108HQR Glycine betaine HUT14_RS13210 ENOG41086VY Fic/DOC family HUT14_RS13240 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT14_RS13255 ENOG4105E2D ec 3.2.1.52 HUT14_RS13280 ENOG4108UJU UPF0301 protein HUT14_RS13285 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT14_RS13290 ENOG4108426 dNA-binding protein HUT14_RS13300 ENOG4105EEM helicase HUT14_RS13325 ENOG4105DQQ Major facilitator superfamily MFS_1 HUT14_RS13365 ENOG4107RTG Major Facilitator superfamily HUT14_RS13390 ENOG4105F04 LysR family Transcriptional regulator HUT14_RS13400 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS13415 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT14_RS13420 ENOG4105CN1 protease HUT14_RS13430 ENOG4105CAK Cell division ATP-binding protein ftsE HUT14_RS13445 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT14_RS13450 ENOG4108QVN serine threonine protein kinase HUT14_RS13455 ENOG4108UGD Serine Threonine protein kinase HUT14_RS13475 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT14_RS13480 ENOG4107SJB teichoic acid biosynthesis HUT14_RS13485 ENOG4107SJB teichoic acid biosynthesis HUT14_RS13490 ENOG4105K64 Glycosyl transferase, family 2 HUT14_RS13505 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT14_RS13510 ENOG4105K56 Transcriptional regulator HUT14_RS13515 ENOG4105CND Glycosyl transferase, family 2 HUT14_RS13540 ENOG4105EY8 ABC transporter HUT14_RS13545 ENOG4107SJB teichoic acid biosynthesis HUT14_RS13560 ENOG4105C7I Dehydrogenase HUT14_RS13580 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT14_RS13590 ENOG4105T0Z Conserved Protein HUT14_RS13595 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS13600 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT14_RS13610 ENOG4105G3P Lipoprotein lpqB HUT14_RS13615 ENOG4105BZU Histidine kinase HUT14_RS13620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS13625 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT14_RS13640 ENOG4108WQ6 secreted protein HUT14_RS13645 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT14_RS13685 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT14_RS13695 ENOG4105EIP mannose-6-phosphate isomerase HUT14_RS13705 ENOG4105W49 UPF0434 protein HUT14_RS13710 ENOG4107QKV phosphomannomutase HUT14_RS13715 ENOG4105DAA L-lactate HUT14_RS13735 ENOG4107RGC Glycosyl transferase, family 2 HUT14_RS13740 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT14_RS13755 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT14_RS13765 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT14_RS13780 ENOG4108KGH TRANSCRIPTIONal HUT14_RS13785 ENOG4108KGH TRANSCRIPTIONal HUT14_RS13790 ENOG4107TB5 TRANSCRIPTIONal HUT14_RS13795 ENOG4108KGH TRANSCRIPTIONal HUT14_RS13810 ENOG4108KGH TRANSCRIPTIONal HUT14_RS13820 ENOG4108KGH TRANSCRIPTIONal HUT14_RS13830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUT14_RS13835 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS13840 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT14_RS13870 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HUT14_RS13885 ENOG41065SU Two-component system sensor kinase HUT14_RS13890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS13895 ENOG4105DUX Transporter HUT14_RS13905 ENOG41082AN stage II sporulation protein HUT14_RS13910 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS13915 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT14_RS13930 ENOG4105CGP Urocanate hydratase HUT14_RS13950 ENOG4108KGH TRANSCRIPTIONal HUT14_RS13970 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS14005 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT14_RS14010 ENOG4107RBB ABC transporter, permease HUT14_RS14015 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT14_RS14020 ENOG4105CEP NADH dehydrogenase HUT14_RS14040 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT14_RS14115 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT14_RS14150 ENOG4105BZU Histidine kinase HUT14_RS14165 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT14_RS14170 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT14_RS14175 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT14_RS14180 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT14_RS14190 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT14_RS14200 ENOG41067SE Tetr family transcriptional regulator HUT14_RS14205 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT14_RS14210 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT14_RS14215 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS14225 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT14_RS14265 ENOG4105C5H ABC transporter HUT14_RS14270 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT14_RS14275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT14_RS14280 ENOG4105F8V Hydrolase, tatD family HUT14_RS14315 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein HUT14_RS14325 ENOG4108JJB ABC transporter HUT14_RS14330 ENOG4105K56 Transcriptional regulator HUT14_RS14360 ENOG4105EYF MMPL domain protein HUT14_RS14380 ENOG4105CHR reductase HUT14_RS14385 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT14_RS14390 ENOG4105F95 Monooxygenase HUT14_RS14400 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT14_RS14405 ENOG4105CGK Exodeoxyribonuclease III HUT14_RS14445 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT14_RS14450 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT14_RS14460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT14_RS14465 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT14_RS14475 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HUT14_RS14490 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT14_RS14525 ENOG4105DM4 PTS System HUT14_RS14530 ENOG4105DE4 1-phosphofructokinase HUT14_RS14535 ENOG410804X Transcriptional regulator HUT14_RS14560 ENOG4108Z7F N-acetyltransferase HUT14_RS14565 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUT14_RS14730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUT14_RS14750 ENOG4105CVK Glutamate decarboxylase HUT14_RS14825 ENOG4108V06 Glutathione peroxidase HUT14_RS14850 ENOG4105DZ1 carboxypeptidase HUT14_RS14895 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT14_RS14930 ENOG4108762 serine threonine protein kinase HUT14_RS14940 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT14_RS14950 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT14_RS14960 ENOG4105H3G oxidoreductase HUT14_RS14965 ENOG4105DCM major facilitator superfamily HUT14_RS14985 ENOG4105WN5 stage II sporulation protein HUT14_RS15040 ENOG4108XEP Alpha Beta Hydrolase Fold protein HUT14_RS15050 ENOG4108SU4 UPF0309 protein HUT14_RS15065 ENOG4105C7N Xanthine uracil vitamin C permease HUT14_RS15075 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT14_RS15090 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS15105 ENOG4107QX3 carboxylase HUT14_RS15120 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HUT14_RS15130 ENOG4107AQZ Membrane HUT14_RS15140 ENOG4105CQB FAD linked oxidase domain protein HUT14_RS15175 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT14_RS15210 ENOG4105CPC Aldo Keto reductase HUT14_RS15240 ENOG4105C7N Xanthine uracil vitamin C permease HUT14_RS15250 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT14_RS15260 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT14_RS15275 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT14_RS15280 ENOG4105DR5 peptidase HUT14_RS15310 ENOG4108N0W Major Facilitator superfamily HUT14_RS15320 ENOG4108UIH futalosine nucleosidase HUT14_RS15325 ENOG4105E63 Pfam:DUF178 HUT14_RS15330 ENOG4105VEQ Cold shock protein HUT14_RS15355 ENOG4105CFI type iii restriction protein res subunit HUT14_RS15365 ENOG4105EEM helicase HUT14_RS15400 ENOG4105QEK Transcriptional regulator HUT14_RS15405 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT14_RS15430 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT14_RS15435 ENOG4105VEQ Cold shock protein HUT14_RS15450 ENOG4105C3Q Glycosyl transferase, family 2 HUT14_RS15475 ENOG4105DKQ ROK family HUT14_RS15480 ENOG4105CE4 GlcNAc 6-P deacetylase HUT14_RS15495 ENOG4105BZU Histidine kinase HUT14_RS15510 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT14_RS15560 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT14_RS15585 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT14_RS15590 ENOG4105C8N cysteinyl-tRNA synthetase HUT14_RS15595 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT14_RS15600 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT14_RS15605 ENOG4108VJ1 Transcriptional regulator (CarD family HUT14_RS15620 ENOG4105BZU Histidine kinase HUT14_RS15640 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT14_RS15655 ENOG4106F59 XRE family Transcriptional regulator HUT14_RS15720 ENOG4108YZJ Pfam:DUF2596 HUT14_RS15725 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT14_RS15745 ENOG4105TT9 Protein of unknown function (DUF2516) HUT14_RS15775 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT14_RS15780 ENOG4105WEM extracellular solute-binding protein HUT14_RS15785 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT14_RS15790 ENOG41073TP transcriptional regulator HUT14_RS15795 ENOG4105EEM helicase HUT14_RS15815 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT14_RS15835 ENOG4105HHS UPF0256 protein HUT14_RS15845 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT14_RS15850 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT14_RS15855 ENOG41090R7 Ferric uptake HUT14_RS15860 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT14_RS15890 ENOG4105PKJ carbohydrate binding HUT14_RS15895 ENOG4105KHC sulfurtransferase HUT14_RS15920 ENOG4107NHD transcriptional regulator HUT14_RS15925 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS15930 ENOG4105C0H protease HUT14_RS15945 ENOG4105DBA pectate lyase HUT14_RS15980 ENOG4105CGH 5'-nucleotidase HUT14_RS15985 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT14_RS16000 ENOG4105CIG ABC transporter HUT14_RS16020 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT14_RS16050 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT14_RS16055 ENOG4105CJ3 phosphate transporter HUT14_RS16065 ENOG4105VPX protein, conserved in bacteria HUT14_RS16085 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUT14_RS16090 ENOG4105K4H Nlp p60 protein HUT14_RS16135 ENOG4105CJ1 ABC, transporter HUT14_RS16145 ENOG4105BZU Histidine kinase HUT14_RS16150 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS16205 ENOG4105D5U fad dependent oxidoreductase HUT14_RS16210 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT14_RS16235 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS16240 ENOG4105BZU Histidine kinase HUT14_RS16255 ENOG4105C1J atp-dependent rna helicase HUT14_RS16290 ENOG4105CQ7 ATP-dependent helicase HUT14_RS16305 ENOG4108TAC HUT14_RS16310 ENOG4107RDP Dehydrogenase HUT14_RS16320 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT14_RS16340 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT14_RS16345 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT14_RS16350 ENOG410839H phosphoribosylformylglycinamidine synthase HUT14_RS16395 ENOG4105C8V SAICAR synthetase HUT14_RS16410 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT14_RS16430 ENOG4105CHR reductase HUT14_RS16450 ENOG4105C39 capsular polysaccharide phosphotransferase HUT14_RS16455 ENOG4105C39 capsular polysaccharide phosphotransferase HUT14_RS16465 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT14_RS16500 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT14_RS16515 ENOG4108Z6B deaminase HUT14_RS16530 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HUT14_RS16535 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS16540 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS16550 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT14_RS16555 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT14_RS16575 ENOG410905P Pyridoxamine 5-phosphate HUT14_RS16580 ENOG4105EDW glycosyl transferase, family 39 HUT14_RS16590 ENOG4105BZU Histidine kinase HUT14_RS16595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS16615 ENOG4107SVH Potassium channel protein HUT14_RS16645 ENOG4108UXN response regulator HUT14_RS16650 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS16655 ENOG4105NAF rna polymerase sigma factor HUT14_RS16695 ENOG4105C0H protease HUT14_RS16710 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT14_RS16725 ENOG4107T6F Xaa-Pro aminopeptidase HUT14_RS16760 ENOG4105DBE peroxidase HUT14_RS16770 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT14_RS16775 ENOG410667J hydrolase HUT14_RS16795 ENOG4105DA5 (ABC) transporter HUT14_RS16805 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HUT14_RS16815 ENOG410667J hydrolase HUT14_RS16825 ENOG4108JJ9 ABC, transporter HUT14_RS16830 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT14_RS16835 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT14_RS16840 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT14_RS16845 ENOG4107P2S Transcriptional regulator HUT14_RS16850 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HUT14_RS16865 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT14_RS16890 ENOG4106048 Cupin 2, conserved barrel domain protein HUT14_RS16895 ENOG41082T9 Membrane HUT14_RS16900 ENOG4105KJF protein tyrosine phosphatase HUT14_RS16905 ENOG4105C28 cystathionine HUT14_RS16930 ENOG4105F27 Major Facilitator HUT14_RS16955 ENOG4105CDU Replicative dna helicase HUT14_RS16965 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT14_RS16970 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT14_RS16975 ENOG4107YH6 single-stranded DNA-binding protein HUT14_RS16980 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT14_RS17005 ENOG4105BZ4 penicillin-binding protein HUT14_RS17015 ENOG4105CZA synthase HUT14_RS17030 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT14_RS17060 ENOG4105C3M thioredoxin reductase HUT14_RS17065 ENOG4105K63 Thioredoxin HUT14_RS17080 ENOG4107QJE Chromosome Partitioning Protein HUT14_RS17085 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT14_RS17095 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT14_RS17100 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT14_RS17105 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HUT14_RS17110 ENOG41084CH 50S ribosomal protein l34 HUT14_RS17115 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HUT14_RS17120 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT14_RS17125 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT14_RS17130 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT14_RS17135 ENOG4105K7N UPF0232 protein HUT14_RS17140 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT14_RS17145 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT14_RS17180 ENOG4108UGD Serine Threonine protein kinase HUT14_RS17210 ENOG4105ZJT Cell division protein CrgA HUT14_RS17230 ENOG4108U4N (sortase) family HUT14_RS17235 ENOG4108RN7 integral membrane protein HUT14_RS17245 ENOG4105CJN penicillin-binding protein HUT14_RS17260 ENOG4105HZM Fha domain containing protein HUT14_RS17265 ENOG4105TV9 FHA Domain-Containing protein HUT14_RS17275 ENOG4107TPS domain protein HUT14_RS17290 ENOG41080RH Thioredoxin HUT14_RS17295 ENOG4105VPX protein, conserved in bacteria HUT14_RS17305 ENOG4105VPX protein, conserved in bacteria HUT14_RS17320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT14_RS17330 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS17340 ENOG41064MX Tetr family transcriptional regulator HUT14_RS17360 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT14_RS17365 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT14_RS17370 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT14_RS17375 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT14_RS17380 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT14_RS17395 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HUT14_RS17405 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT14_RS17410 ENOG4108IG5 Transcriptional regulator HUT14_RS17430 ENOG4107QSN dihydrolipoamide acetyltransferase HUT14_RS17440 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUT14_RS17475 ENOG4107QPV Serine Threonine protein kinase HUT14_RS17490 ENOG4105CPP Dehydrogenase, E1 component HUT14_RS17495 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT14_RS17540 ENOG4105DFM M18 family aminopeptidase HUT14_RS17545 ENOG4105CSU acyl-Coa dehydrogenase HUT14_RS17555 ENOG4105EUB pirin domain protein HUT14_RS17565 ENOG4105C9M aspartyl-trna synthetase HUT14_RS17575 ENOG4105KWG Pfam:DUF1696 HUT14_RS17580 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT14_RS17595 ENOG4108KXM LysR family Transcriptional regulator HUT14_RS17650 ENOG4105CG3 alpha amylase, catalytic region HUT14_RS17685 ENOG4105VEQ Cold shock protein HUT14_RS17695 ENOG4106NZI LysR family Transcriptional regulator HUT14_RS17705 ENOG4108J4B Beta-lactamase HUT14_RS17715 ENOG4105DFW ABC transporter HUT14_RS17725 ENOG4105EXC Acyl-transferase HUT14_RS17730 ENOG4108KPJ rna polymerase sigma factor HUT14_RS17750 ENOG4108R96 Methyltransferase, YaeB family HUT14_RS17760 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT14_RS17870 ENOG4105CMR udp-glucose 4-epimerase HUT14_RS17900 ENOG4108S01 response regulator HUT14_RS17905 ENOG4108ZGX Histidine kinase HUT14_RS17925 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT14_RS17935 ENOG4105DHP deoxycytidine triphosphate deaminase HUT14_RS17940 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HUT14_RS17960 ENOG4105DF6 Fe-S oxidoreductase HUT14_RS17970 ENOG4105CFG Acts as a chaperone (By similarity) HUT14_RS17975 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT14_RS17980 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT14_RS17985 ENOG4105KNI merR family transcriptional Regulator HUT14_RS17990 ENOG4105DFW ABC transporter HUT14_RS18025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT14_RS18060 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUT14_RS18070 ENOG4108ZKT aldose 1-epimerase HUT14_RS18075 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUT14_RS18080 ENOG4107RCW fructose-bisphosphate aldolase HUT14_RS18120 ENOG4105BZU Histidine kinase HUT14_RS18125 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS18130 ENOG4105BZU Histidine kinase HUT14_RS18135 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS18145 ENOG4105DIM ABC transporter HUT14_RS18150 ENOG4105CIG ABC transporter HUT14_RS18170 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT14_RS18185 ENOG4105DRR Transcriptional regulator, GntR family HUT14_RS18190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT14_RS18195 ENOG4108V4B ThiJ pfpI HUT14_RS18210 ENOG4105CVA phosphate HUT14_RS18220 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT14_RS18225 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT14_RS18240 ENOG4105CFH Aspartokinase HUT14_RS18275 ENOG4108PJD permease HUT14_RS18420 ENOG4105QCJ Lipoprotein HUT14_RS18430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT14_RS18435 ENOG4105C59 p-type ATPase HUT14_RS18555 ENOG4105BZ4 penicillin-binding protein HUT14_RS18590 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT14_RS18605 ENOG4105P8F nudix hydrolase HUT14_RS18615 ENOG4105D74 hydrolase HUT14_RS18625 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT14_RS18630 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT14_RS18635 ENOG4107B2H carbonic anhydrase HUT14_RS18700 ENOG4105WN5 stage II sporulation protein HUT14_RS18705 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT14_RS18710 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT14_RS18720 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT14_RS18730 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT14_RS18735 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT14_RS18770 ENOG4105C2M dna polymerase I HUT14_RS18810 ENOG4105C26 Dehydrogenase HUT14_RS18835 ENOG4107TXC Transcriptional regulator HUT14_RS18840 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT14_RS18850 ENOG4105F0N pyrophosphate phospho-hydrolase HUT14_RS18865 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT14_RS18870 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUT14_RS18880 ENOG4105EUJ GTP cyclohydrolase i HUT14_RS18890 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUT14_RS18925 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS18945 ENOG4105I1F Resistance protein HUT14_RS18965 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT14_RS18970 ENOG4108IYU L-aspartate oxidase HUT14_RS18980 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT14_RS19025 ENOG4105DR5 peptidase HUT14_RS19030 ENOG4108IG5 Transcriptional regulator HUT14_RS19040 ENOG4108FKE two-component system sensor kinase HUT14_RS19045 ENOG4108PYU two-component system response regulator HUT14_RS19050 ENOG41075QH Lipoprotein CseA HUT14_RS19055 ENOG4105NAF rna polymerase sigma factor HUT14_RS19060 ENOG4105CEN a g-specific adenine glycosylase HUT14_RS19065 ENOG4105BZU Histidine kinase HUT14_RS19085 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT14_RS19100 ENOG4108JWX HUT14_RS19105 ENOG4107R33 ppx gppa phosphatase HUT14_RS19110 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT14_RS19115 ENOG4105PF9 Transcriptional regulator HUT14_RS19120 ENOG4105C01 Dihydroxy-acid dehydratase HUT14_RS19145 ENOG4105CJ1 ABC, transporter HUT14_RS19155 ENOG4105II7 pyrroline-5-carboxylate reductase HUT14_RS19165 ENOG4105ECQ AraC Family Transcriptional Regulator HUT14_RS19170 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT14_RS19200 ENOG4105DGU Histone deacetylase HUT14_RS19250 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT14_RS19255 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT14_RS19260 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT14_RS19265 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT14_RS19300 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT14_RS19330 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT14_RS19350 ENOG4105GAK amidohydrolase 2 HUT14_RS19355 ENOG4105KHM amidohydrolase 2 HUT14_RS19360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS19380 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT14_RS19385 ENOG4105C75 arginyL-tRNA synthetase HUT14_RS19390 ENOG4105DK7 lysyl-tRNA synthetase HUT14_RS19410 ENOG4105E0Y RtcB Protein HUT14_RS19420 ENOG4105KK4 UPF0060 membrane protein HUT14_RS19430 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT14_RS19435 ENOG4108UZX fmn reductase HUT14_RS19445 ENOG41062D9 Histidine kinase HUT14_RS19450 ENOG4107S4Y M20 DapE family protein YgeY HUT14_RS19455 ENOG4105K4I Scp-like extracellular HUT14_RS19490 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS19510 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT14_RS19515 ENOG4108RH7 phosphoglycerate mutase HUT14_RS19530 ENOG4107QIV Cytochrome c biogenesis protein HUT14_RS19535 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HUT14_RS19540 ENOG4105CRE cytochrome C HUT14_RS19585 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUT14_RS19590 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HUT14_RS19600 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUT14_RS19610 ENOG4105DVY radical SAM domain protein HUT14_RS19625 ENOG4107QJT sodium dicarboxylate symporter HUT14_RS19650 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT14_RS19660 ENOG4105CHR reductase HUT14_RS19665 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS19675 ENOG4105VEQ Cold shock protein HUT14_RS19680 ENOG4105EV6 Pfam:DUF178 HUT14_RS19690 ENOG4105EC2 ftsk spoIIIe HUT14_RS19770 ENOG4108EHY type IV secretion system HUT14_RS19820 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT14_RS19830 ENOG4108NNZ chitinase HUT14_RS19840 ENOG4107QJZ Glycosyl transferase, family 2 HUT14_RS19850 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT14_RS19870 ENOG41068JE domain protein HUT14_RS19880 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS19885 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT14_RS19890 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS19900 ENOG4107QIZ NADH dehydrogenase HUT14_RS19905 ENOG4108IEH NADH dehydrogenase subunit g HUT14_RS19910 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT14_RS19915 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS19920 ENOG41087XN oxidoreductase HUT14_RS19925 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS19930 ENOG4105D65 subunit l HUT14_RS19940 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS19945 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT14_RS20000 ENOG410667J hydrolase HUT14_RS20020 ENOG4105CJ1 ABC, transporter HUT14_RS20035 ENOG4108WS4 fmn reductase HUT14_RS20055 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT14_RS20090 ENOG4105ECR NmrA family HUT14_RS20095 ENOG4105KVH Transcriptional regulator HUT14_RS20100 ENOG4105DQU oxidoreductase, subunit beta HUT14_RS20105 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT14_RS20125 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT14_RS20130 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS20135 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT14_RS20140 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT14_RS20145 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS20150 ENOG4107YX3 NADH dehydrogenase subunit j HUT14_RS20155 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS20160 ENOG4105D65 subunit l HUT14_RS20170 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT14_RS20175 ENOG4105D0M Protease HtpX homolog HUT14_RS20180 ENOG410901E Membrane HUT14_RS20195 ENOG4105Y3U Transglycosylase-associated protein HUT14_RS20200 ENOG4108VPT UPF0234 protein HUT14_RS20235 ENOG4105WDJ 50S ribosomal protein L33 HUT14_RS20240 ENOG410900P UPF0336 protein HUT14_RS20250 ENOG4107R4N Cell wall formation (By similarity) HUT14_RS20255 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT14_RS20275 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUT14_RS20280 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT14_RS20285 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT14_RS20295 ENOG4108VZM 50s ribosomal protein L10 HUT14_RS20300 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT14_RS20305 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT14_RS20310 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT14_RS20320 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT14_RS20325 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT14_RS20330 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT14_RS20335 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT14_RS20360 ENOG4105CPC Aldo Keto reductase HUT14_RS20375 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS20380 ENOG4105BZU Histidine kinase HUT14_RS20385 ENOG4107R37 Glutamate dehydrogenase HUT14_RS20395 ENOG4105CHR reductase HUT14_RS20430 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT14_RS20435 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT14_RS20440 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT14_RS20445 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT14_RS20450 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT14_RS20455 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT14_RS20460 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT14_RS20465 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT14_RS20470 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT14_RS20475 ENOG41082SA 50s ribosomal protein l29 HUT14_RS20480 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT14_RS20485 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT14_RS20490 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT14_RS20495 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT14_RS20500 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT14_RS20505 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT14_RS20510 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT14_RS20515 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT14_RS20520 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT14_RS20525 ENOG410849U 50S ribosomal protein L30 HUT14_RS20530 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT14_RS20540 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT14_RS20550 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT14_RS20555 ENOG41067V7 50S ribosomal protein L36 HUT14_RS20560 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT14_RS20565 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT14_RS20570 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT14_RS20575 ENOG4108ZT0 50S ribosomal protein l17 HUT14_RS20580 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT14_RS20590 ENOG4105PNM synthesis protein HUT14_RS20625 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT14_RS20630 ENOG4108UJD 30S ribosomal protein S9 HUT14_RS20635 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT14_RS20645 ENOG4105CS9 pantothenic acid kinase HUT14_RS20655 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT14_RS20665 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS20680 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT14_RS20685 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT14_RS20690 ENOG4108097 ATP-binding protein HUT14_RS20715 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT14_RS20735 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS20740 ENOG4108KGH TRANSCRIPTIONal HUT14_RS20750 ENOG4105CHP RNA polymerase HUT14_RS20770 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT14_RS20775 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT14_RS20830 ENOG4105EMU Dehydrogenase HUT14_RS20840 ENOG4105DND Transcriptional regulator HUT14_RS20845 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT14_RS20855 ENOG4108MMM RNA Polymerase HUT14_RS20865 ENOG4107QVP Dehydrogenase HUT14_RS20870 ENOG4107QQG Dehydrogenase HUT14_RS20875 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT14_RS20895 ENOG4107TPY serine threonine protein kinase HUT14_RS20900 ENOG4108UGD Serine Threonine protein kinase HUT14_RS20905 ENOG4107TPY serine threonine protein kinase HUT14_RS20910 ENOG4105C26 Dehydrogenase HUT14_RS20935 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT14_RS20975 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS20995 ENOG4105DR5 peptidase HUT14_RS21020 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT14_RS21025 ENOG4105RD5 HUT14_RS21030 ENOG4105DEG Vwa containing coxe family protein HUT14_RS21040 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT14_RS21070 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT14_RS21085 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT14_RS21100 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUT14_RS21115 ENOG4108IJ7 Glycine betaine HUT14_RS21120 ENOG4108HQS Glycine betaine HUT14_RS21130 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT14_RS21140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT14_RS21150 ENOG4106032 Glutathionylspermidine synthase HUT14_RS21155 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT14_RS21165 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT14_RS21200 ENOG4107H3J ribonuclease HUT14_RS21215 ENOG4107RN3 metallophosphoesterase HUT14_RS21220 ENOG4105U5Y Transcriptional regulator HUT14_RS21240 ENOG4108J01 L-aspartate oxidase HUT14_RS21260 ENOG4105E2D ec 3.2.1.52 HUT14_RS21315 ENOG4105D5P Methylmalonyl-coA mutase HUT14_RS21325 ENOG4108NIW Leucine export protein LeuE HUT14_RS21345 ENOG4107QRS glycosyltransferase group 2 family protein HUT14_RS21365 ENOG4105K64 Glycosyl transferase, family 2 HUT14_RS21375 ENOG4105F0R Cytidylyltransferase HUT14_RS21380 ENOG4105D2T synthase HUT14_RS21390 ENOG4107RM1 amidohydrolase HUT14_RS21395 ENOG4105DIH basic membrane HUT14_RS21400 ENOG4105DIH basic membrane HUT14_RS21405 ENOG4108JQ9 ABC transporter HUT14_RS21450 ENOG4105D94 Major Facilitator Superfamily HUT14_RS21455 ENOG4107RSM transcriptional regulator HUT14_RS21465 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT14_RS21490 ENOG41065SU Two-component system sensor kinase HUT14_RS21495 ENOG4108KXV response regulator HUT14_RS21500 ENOG4105NAF rna polymerase sigma factor HUT14_RS21515 ENOG4105C26 Dehydrogenase HUT14_RS21520 ENOG4105C26 Dehydrogenase HUT14_RS21525 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUT14_RS21535 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT14_RS21560 ENOG4108JIK carboxylase HUT14_RS21570 ENOG4107WR6 Maf-like protein HUT14_RS21580 ENOG4105D8K carboxyl transferase HUT14_RS21590 ENOG4108QER Adenylate cyclase HUT14_RS21600 ENOG4105E39 Enoyl-CoA hydratase HUT14_RS21605 ENOG4105KDM Diguanylate cyclase with gaf sensor HUT14_RS21610 ENOG4105C84 Histidine ammonia-lyase HUT14_RS21635 ENOG4105C19 ABC transporter HUT14_RS21650 ENOG4105DQ4 alcohol dehydrogenase HUT14_RS21660 ENOG4108762 serine threonine protein kinase HUT14_RS21680 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT14_RS21685 ENOG4105C7B Threonine dehydratase HUT14_RS21700 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT14_RS21710 ENOG4105T1M mycothiol conjugate amidase mca HUT14_RS21745 ENOG4105C7Z Conserved Protein HUT14_RS21760 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT14_RS21785 ENOG41061H0 Monooxygenase HUT14_RS21900 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT14_RS21905 ENOG4105C3F Signal peptidase i HUT14_RS21955 ENOG4105CHM Aminotransferase HUT14_RS21985 ENOG4108FUF Transcriptional regulator, IclR family HUT14_RS21995 ENOG4105C6Z Gluconate HUT14_RS22065 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS22155 ENOG4105F2W methyltransferase HUT14_RS22160 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT14_RS22165 ENOG4108IAB Phoh family HUT14_RS22180 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT14_RS22185 ENOG4105D3R alkyl hydroperoxide reductase HUT14_RS22200 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT14_RS22220 ENOG4105BZ4 penicillin-binding protein HUT14_RS22235 ENOG4105C9Q fumarate hydratase class II HUT14_RS22265 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT14_RS22280 ENOG4107GFK fumarate HUT14_RS22290 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT14_RS22305 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT14_RS22315 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT14_RS22320 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT14_RS22325 ENOG4105DFK Polyphosphate glucokinase HUT14_RS22335 ENOG4105C3G gtp-binding protein HUT14_RS22365 ENOG4107MMM Anti-sigma-factor antagonist HUT14_RS22370 ENOG4105FUA antagonist HUT14_RS22375 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT14_RS22400 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT14_RS22450 ENOG4105E33 succinate dehydrogenase HUT14_RS22455 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT14_RS22475 ENOG4105CI3 gtp-binding protein typa HUT14_RS22480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT14_RS22500 ENOG4108JQ7 (ABC) transporter HUT14_RS22510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT14_RS22515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT14_RS22525 ENOG4108JQ7 (ABC) transporter HUT14_RS22540 ENOG4105DV0 amidase (EC 3.5.1.4 HUT14_RS22580 ENOG4108Z4U Ferredoxin HUT14_RS22600 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT14_RS22605 ENOG4108URH decarboxylase HUT14_RS22620 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT14_RS22625 ENOG4105CGU Enoyl-CoA hydratase HUT14_RS22640 ENOG4105DU6 RNA polymerase HUT14_RS22655 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT14_RS22690 ENOG4105D7N magnesium and cobalt transport protein CorA HUT14_RS22700 ENOG4105DXB Major Facilitator superfamily HUT14_RS22710 ENOG4105DB7 PHP domain protein HUT14_RS22715 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HUT14_RS22800 ENOG4106JDR secreted HUT14_RS22825 ENOG4105C4R Atp-dependent dna helicase HUT14_RS22830 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT14_RS22835 ENOG4105E09 nadh pyrophosphatase HUT14_RS22855 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT14_RS22870 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HUT14_RS22925 ENOG41063PX domain protein HUT14_RS22935 ENOG4105DJZ UPF0182 protein HUT14_RS22970 ENOG4107TK4 histidinol-phosphate phosphatase HUT14_RS22980 ENOG4105KPY Small multidrug resistance protein HUT14_RS22985 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT14_RS22990 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT14_RS23000 ENOG4108RAV Conserved protein HUT14_RS23010 ENOG4105EMN RNA polymerase sigma factor HUT14_RS23015 ENOG4105WMN AntiSigma factor HUT14_RS23020 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT14_RS23035 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT14_RS23045 ENOG41068W2 Cytochrome p-450 HUT14_RS23050 ENOG4105ECQ AraC Family Transcriptional Regulator HUT14_RS23060 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT14_RS23065 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT14_RS23085 ENOG4105FDP GntR family transcriptional regulator HUT14_RS23090 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HUT14_RS23105 ENOG4105CBD Diacylglycerol kinase HUT14_RS23115 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS23150 ENOG4105ESN nucleotide-binding protein HUT14_RS23160 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT14_RS23170 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT14_RS23205 ENOG4108VEQ Superoxide dismutase HUT14_RS23225 ENOG4105CDA abc transporter atp-binding protein HUT14_RS23240 ENOG4105C6K Malic enzyme HUT14_RS23245 ENOG4105CB2 alcohol dehydrogenase HUT14_RS23275 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT14_RS23280 ENOG4105EB3 Histidine kinase HUT14_RS23285 ENOG4108PYU two-component system response regulator HUT14_RS23290 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT14_RS23295 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT14_RS23365 ENOG4105CJN penicillin-binding protein HUT14_RS23370 ENOG4107QHZ cell cycle protein HUT14_RS23390 ENOG4105DQE DNA ligase HUT14_RS23395 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT14_RS23400 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT14_RS23415 ENOG4105K6V RNA polymerase HUT14_RS23420 ENOG4105RNG membrane HUT14_RS23430 ENOG410906A Beta-Ig-H3 fasciclin HUT14_RS23465 ENOG4107S2Z UPF0761 membrane protein HUT14_RS23470 ENOG41082AN stage II sporulation protein HUT14_RS23620 ENOG4105C75 arginyL-tRNA synthetase HUT14_RS23625 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT14_RS23630 ENOG4105D6E homoserine dehydrogenase HUT14_RS23635 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT14_RS23640 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT14_RS23650 ENOG4108RCF TRANSCRIPTIONal HUT14_RS23655 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT14_RS23660 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT14_RS23665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT14_RS23675 ENOG4107ZF2 Phosphatase HUT14_RS23680 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT14_RS23685 ENOG4105ESV Glycosyl transferase, family 4 HUT14_RS23690 ENOG4105Z3P ATP synthase HUT14_RS23700 ENOG4105ZA1 atp synthase HUT14_RS23705 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT14_RS23710 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT14_RS23715 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT14_RS23720 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT14_RS23725 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT14_RS23730 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT14_RS23745 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS23750 ENOG4105BZU Histidine kinase HUT14_RS23755 ENOG4105IIP Membrane HUT14_RS23785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT14_RS23800 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT14_RS23835 ENOG4105CJ1 ABC, transporter HUT14_RS23855 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS23870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS23925 ENOG4105WX6 Membrane HUT14_RS23970 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT14_RS23975 ENOG4105C6K Malic enzyme HUT14_RS23980 ENOG4105CTQ phosphohexokinase HUT14_RS24000 ENOG4105WEM extracellular solute-binding protein HUT14_RS24005 ENOG4108MRH transcriptional regulatory protein HUT14_RS24015 ENOG4105CK2 sodium dicarboxylate symporter HUT14_RS24020 ENOG4108Z6Z Transcriptional regulator HUT14_RS24035 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT14_RS24040 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HUT14_RS24050 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT14_RS24055 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUT14_RS24075 ENOG4105BZ1 (ABC) transporter HUT14_RS24080 ENOG4105BZ1 (ABC) transporter HUT14_RS24085 ENOG4105BZ1 (ABC) transporter HUT14_RS24090 ENOG4105BZ1 (ABC) transporter HUT14_RS24095 ENOG4105CJ1 ABC, transporter HUT14_RS24105 ENOG4105BZU Histidine kinase HUT14_RS24110 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS24165 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HUT14_RS24175 ENOG4105DKT Transcriptional regulator HUT14_RS24195 ENOG4106F1P AAA ATPase, central domain protein HUT14_RS24205 ENOG4105EC2 ftsk spoIIIe HUT14_RS24270 ENOG4105EJQ L-serine dehydratase HUT14_RS24275 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT14_RS24280 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUT14_RS24285 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT14_RS24305 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT14_RS24310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT14_RS24315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT14_RS24320 ENOG4105C3U ABC transporter HUT14_RS24325 ENOG4108JQ7 (ABC) transporter HUT14_RS24330 ENOG4105EN6 Membrane HUT14_RS24340 ENOG4105EJ2 Transcriptional regulator HUT14_RS24370 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT14_RS24390 ENOG4108URH decarboxylase HUT14_RS24395 ENOG4105EMU Dehydrogenase HUT14_RS24405 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT14_RS24410 ENOG4105BZU Histidine kinase HUT14_RS24415 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT14_RS24420 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT14_RS24430 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT14_RS24435 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT14_RS24445 ENOG4105EYF MMPL domain protein HUT14_RS24450 ENOG4105D9U N-acetyltransferase HUT14_RS24460 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS24475 ENOG4105CPC Aldo Keto reductase HUT14_RS24485 ENOG4105BZU Histidine kinase HUT14_RS24495 ENOG4108ZP8 Acetolactate synthase small subunit HUT14_RS24500 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT14_RS24505 ENOG4108JQ1 Dehydrogenase HUT14_RS24510 ENOG4105C57 major facilitator superfamily HUT14_RS24520 ENOG4107YHD transcriptional regulator HUT14_RS24530 ENOG4105C26 Dehydrogenase HUT14_RS24535 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT14_RS24540 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT14_RS24545 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT14_RS24560 ENOG4105EPH radical SAM domain protein HUT14_RS24565 ENOG4108W6C Dehydrogenase HUT14_RS24570 ENOG4105D8K carboxyl transferase HUT14_RS24590 ENOG4105GWZ Roadblock lc7 family protein HUT14_RS24610 ENOG4105GWZ Roadblock lc7 family protein HUT14_RS24625 ENOG4105ERH Fumarylacetoacetate hydrolase HUT14_RS24630 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT14_RS24675 ENOG41069M3 Transcriptional regulator HUT14_RS24680 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT14_RS24685 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT14_RS24695 ENOG4105K70 DNA-binding protein HUT14_RS24715 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT14_RS24720 ENOG4105CPF Cell wall formation (By similarity) HUT14_RS24740 ENOG4105DWF phosphomethylpyrimidine kinase HUT14_RS24745 ENOG4105VB9 50S ribosomal protein l28 HUT14_RS24750 ENOG4105DP4 dak2 domain fusion protein ylov HUT14_RS24760 ENOG4106H78 methyltransferase HUT14_RS24765 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT14_RS24780 ENOG41084BZ 50S ribosomal protein L32 HUT14_RS24785 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT14_RS24790 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT14_RS24795 ENOG4105KVH Transcriptional regulator HUT14_RS24830 ENOG4105K4I Scp-like extracellular HUT14_RS24835 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUT14_RS24845 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUT14_RS24880 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT14_RS24900 ENOG4105K5M 30s ribosomal protein S16 HUT14_RS24905 ENOG41082KU UPF0109 protein HUT14_RS24910 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT14_RS24915 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT14_RS24920 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT14_RS24935 ENOG4107QYR Signal peptidase i HUT14_RS24940 ENOG4107QYR Signal peptidase i HUT14_RS24945 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT14_RS24955 ENOG41080R2 UPF0102 protein HUT14_RS24970 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS24980 ENOG41063SB peptidase HUT14_RS24985 ENOG4105CE9 30S ribosomal protein S2 HUT14_RS24990 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT14_RS24995 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT14_RS25000 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT14_RS25005 ENOG4105KNE Phosphatidate cytidylyltransferase HUT14_RS25015 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT14_RS25025 ENOG4108I5D sulfate abc transporter HUT14_RS25030 ENOG4108UCS ABC, transporter HUT14_RS25060 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT14_RS25065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT14_RS25075 ENOG4105C26 Dehydrogenase HUT14_RS25090 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT14_RS25120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT14_RS25130 ENOG4105D38 putrescine abc transporter HUT14_RS25135 ENOG4105CJP fad dependent oxidoreductase HUT14_RS25155 ENOG4105G9B Transcriptional regulator HUT14_RS25165 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT14_RS25180 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT14_RS25205 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS25210 ENOG4105ENE Histidine kinase HUT14_RS25220 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT14_RS25230 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUT14_RS25235 ENOG4105DZP Membrane-associated zinc metalloprotease HUT14_RS25240 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT14_RS25255 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT14_RS25260 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HUT14_RS25275 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT14_RS25290 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT14_RS25300 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT14_RS25305 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT14_RS25320 ENOG4108JQ7 (ABC) transporter HUT14_RS25325 ENOG4105C3U ABC transporter HUT14_RS25335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT14_RS25340 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT14_RS25355 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT14_RS25360 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT14_RS25365 ENOG4105C1V Peptidase, M16 HUT14_RS25370 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT14_RS25390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT14_RS25395 ENOG4105CN5 Metallo-Beta-Lactamase HUT14_RS25415 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT14_RS25435 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT14_RS25450 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT14_RS25460 ENOG4105CEV competence damage-inducible protein HUT14_RS25465 ENOG4105WBV Transcriptional regulator HUT14_RS25470 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT14_RS25480 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT14_RS25485 ENOG4107QRT dEAD DEAH box helicase HUT14_RS25515 ENOG4105DSF transport protein HUT14_RS25520 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT14_RS25550 ENOG4105DU1 integral membrane protein, terc HUT14_RS25565 ENOG4107SCK Monooxygenase HUT14_RS25570 ENOG4105DRP amino acid AbC transporter HUT14_RS25575 ENOG4108Q1T ABC transporter HUT14_RS25580 ENOG4107UBR Extracellular solute-binding protein family 3 HUT14_RS25585 ENOG4105CDA abc transporter atp-binding protein HUT14_RS25590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS25595 ENOG41065SU Two-component system sensor kinase HUT14_RS25600 ENOG4105H1G trap transporter solute receptor taxi family HUT14_RS25615 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT14_RS25635 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT14_RS25645 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT14_RS25650 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT14_RS25655 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT14_RS25685 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT14_RS25690 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT14_RS25695 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT14_RS25710 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT14_RS25730 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT14_RS25745 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT14_RS25755 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT14_RS25765 ENOG4105DRR Transcriptional regulator, GntR family HUT14_RS25780 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT14_RS25790 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT14_RS25800 ENOG4107QN1 sodium solute HUT14_RS25805 ENOG4108V9W transcriptional regulatory protein HUT14_RS25835 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT14_RS25855 ENOG4105DRR Transcriptional regulator, GntR family HUT14_RS25860 ENOG410849S phosphocarrier protein (HPr) HUT14_RS25865 ENOG4105CD5 CoA-binding domain protein HUT14_RS25880 ENOG4107W53 thymidine kinase HUT14_RS25900 ENOG4105EZM VWA-like domain (DUF2201) HUT14_RS25905 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT14_RS25960 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT14_RS25975 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT14_RS25980 ENOG4106F60 Histidine kinase HUT14_RS26005 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT14_RS26015 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT14_RS26045 ENOG4107VEG TrkA-N domain protein HUT14_RS26050 ENOG4108U3T pfkb domain protein HUT14_RS26055 ENOG4105C0X amino acid HUT14_RS26060 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT14_RS26105 ENOG4105CHH sulfate transporter HUT14_RS26110 ENOG4105W1Y Transcriptional regulator HUT14_RS26120 ENOG41082YX Transcriptional regulator, arsr family HUT14_RS26125 ENOG4105H3G oxidoreductase HUT14_RS26145 ENOG4106JDR secreted HUT14_RS26170 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS26175 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT14_RS26190 ENOG4107RSM transcriptional regulator HUT14_RS26195 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS26200 ENOG4105CSH Transporter HUT14_RS26215 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT14_RS26220 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUT14_RS26230 ENOG4105K64 Glycosyl transferase, family 2 HUT14_RS26240 ENOG4105EQQ protein containing aminopeptidase domain HUT14_RS26245 ENOG4105CMR udp-glucose 4-epimerase HUT14_RS26255 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HUT14_RS26290 ENOG4105CAQ asparagine synthetase HUT14_RS26310 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT14_RS26315 ENOG4105D3Q Sugar transferase HUT14_RS26325 ENOG4108JQ6 ABC transporter HUT14_RS26330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT14_RS26335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT14_RS26340 ENOG4105E43 Extracellular solute-binding protein, family 5 HUT14_RS26355 ENOG4105DTQ mandelate racemase muconate lactonizing HUT14_RS26360 ENOG410880H cysteine synthase HUT14_RS26370 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT14_RS26380 ENOG4107YCY Transcriptional regulator HUT14_RS26385 ENOG4105DQU oxidoreductase, subunit beta HUT14_RS26390 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT14_RS26395 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT14_RS26445 ENOG4105BZU Histidine kinase HUT14_RS26475 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS26485 ENOG4107QKG PfaD family HUT14_RS26495 ENOG4108JA1 polyketide synthase HUT14_RS26495 ENOG4108JA1 polyketide synthase HUT14_RS26510 ENOG4105BZU Histidine kinase HUT14_RS26515 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT14_RS26530 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT14_RS26535 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT14_RS26545 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT14_RS26555 ENOG4105DZS Phenylacetate-CoA ligase HUT14_RS26590 ENOG4105F0K SARP family transcriptional regulator HUT14_RS26600 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT14_RS26615 ENOG4105F0K SARP family transcriptional regulator HUT14_RS26620 ENOG410804X Transcriptional regulator HUT14_RS26625 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HUT14_RS26635 ENOG4105CPC Aldo Keto reductase HUT14_RS26640 ENOG4105CNV Aldolase HUT14_RS26650 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HUT14_RS26670 ENOG4105FDP GntR family transcriptional regulator HUT14_RS26690 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT14_RS26730 ENOG4107S1Q Phosphatase HUT14_RS26740 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT14_RS26760 ENOG4105CEU Arginine dihydrolase HUT14_RS26765 ENOG4105DBV ornithine carbamoyltransferase HUT14_RS26775 ENOG4105CGU Enoyl-CoA hydratase HUT14_RS26830 ENOG4108TCJ secreted hydrolase HUT14_RS26835 ENOG4108JJB ABC transporter HUT14_RS26850 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HUT14_RS26865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT14_RS26870 ENOG4105C3U ABC transporter HUT14_RS26875 ENOG4108JQ7 (ABC) transporter HUT14_RS26890 ENOG4105EPJ extracellular solute-binding protein family 1 HUT14_RS26905 ENOG4107Q25 Serine Threonine protein kinase HUT14_RS26965 ENOG4107QN1 sodium solute HUT14_RS27000 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT14_RS27010 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid HUT14_RS27015 ENOG4107QM5 aconitate hydratase HUT14_RS27055 ENOG4105E2R ROK family HUT14_RS27060 ENOG4105DFW ABC transporter HUT14_RS27065 ENOG4105C2J ABC transporter HUT14_RS27070 ENOG4108HWW ABC transporter HUT14_RS27075 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT14_RS27080 ENOG4105CUB amino acid HUT14_RS27095 ENOG4108KGH TRANSCRIPTIONal HUT14_RS27100 ENOG4107SJB teichoic acid biosynthesis HUT14_RS27120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT14_RS27125 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS27130 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS27145 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT14_RS27155 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HUT14_RS27170 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT14_RS27205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT14_RS27210 ENOG4107QZB decarboxylase HUT14_RS27235 ENOG4105BZ1 (ABC) transporter HUT14_RS27250 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS27275 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS27280 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS27285 ENOG4105BZU Histidine kinase HUT14_RS27305 ENOG4107RCI amp-dependent synthetase and ligase HUT14_RS27325 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUT14_RS27335 ENOG4105C1Q protoporphyrinogen oxidase HUT14_RS27340 ENOG4107JTW chlorite dismutase HUT14_RS27355 ENOG4105E18 UPF0276 protein HUT14_RS27360 ENOG4107R72 Ceramidase HUT14_RS27380 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HUT14_RS27400 ENOG4105CHH sulfate transporter HUT14_RS27405 ENOG4107B2H carbonic anhydrase HUT14_RS27425 ENOG4105DFU Cell wall formation (By similarity) HUT14_RS27430 ENOG4105E0X reductase HUT14_RS27460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS27465 ENOG4105BZU Histidine kinase HUT14_RS27475 ENOG4105BZU Histidine kinase HUT14_RS27480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT14_RS27500 ENOG4105JXH GntR family transcriptional regulator HUT14_RS27510 ENOG4105CMT Dihydroxyacetone kinase HUT14_RS27515 ENOG4107YVI ribose 5-phosphate isomerase HUT14_RS27520 ENOG4105CP7 Triose-phosphate isomerase HUT14_RS27525 ENOG4108KFM Xylose Isomerase Domain-Containing protein HUT14_RS27530 ENOG4106J7G oxidoreductase HUT14_RS27535 ENOG4108IJ8 ABC transporter HUT14_RS27540 ENOG4105E90 ABC transporter HUT14_RS27545 ENOG4105E90 ABC transporter HUT14_RS27585 ENOG4108XG4 DNA-binding transcriptional regulator HUT14_RS27595 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT14_RS27605 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HUT14_RS27635 ENOG4105ZSU inhibitor HUT14_RS27690 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT14_RS27720 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT14_RS27745 ENOG4107RR1 TRANSCRIPTIONal HUT14_RS27750 ENOG4105CSU acyl-Coa dehydrogenase HUT14_RS27765 ENOG4105E7U AraC family transcriptional regulator HUT14_RS27790 ENOG4105EBR Carboxylesterase HUT14_RS27810 ENOG4108Z6Z Transcriptional regulator HUT14_RS27835 ENOG4108J5H Homocysteine s-methyltransferase HUT14_RS27840 ENOG41086KC Transcriptional regulator HUT14_RS27880 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT14_RS27890 ENOG4107TDE lipolytic protein G-D-S-L family HUT14_RS27945 ENOG4105QE3 oxidoreductase HUT14_RS27955 ENOG41065HY 1,4-beta-cellobiosidase HUT14_RS27960 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT14_RS27970 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT14_RS27985 ENOG4105C7K acetolactate synthase HUT14_RS28015 ENOG4105DRR Transcriptional regulator, GntR family HUT14_RS28040 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT14_RS28070 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUT14_RS28080 ENOG4105CPK Glycosyl transferase (Group 1 HUT14_RS28085 ENOG4105D16 lipopolysaccharide heptosyltransferase i HUT14_RS28085 ENOG4105D16 lipopolysaccharide heptosyltransferase i HUT14_RS28090 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT14_RS28115 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT14_RS28130 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT14_RS28135 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS28140 ENOG41060W2 glyoxylate carboligase HUT14_RS28155 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUT14_RS28160 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HUT14_RS28180 ENOG4105VT2 5-hydroxyisourate hydrolase HUT14_RS28190 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT14_RS28255 ENOG4107U32 Beta-lactamase domain protein HUT14_RS28305 ENOG4107R9S Malate synthase HUT14_RS28320 ENOG4107HP6 Transcriptional regulator HUT14_RS28330 ENOG4105DHG Allantoate amidinohydrolase HUT14_RS28335 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT14_RS28355 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS28365 ENOG4106448 streptomycin biosynthesis protein strI HUT14_RS28380 ENOG4105CNN ABC, transporter HUT14_RS28385 ENOG4105C2J ABC transporter HUT14_RS28390 ENOG4105DKQ ROK family HUT14_RS28400 ENOG4105C0D helicase HUT14_RS28470 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HUT14_RS28475 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT14_RS28480 ENOG4105CGD Nad-dependent epimerase dehydratase HUT14_RS28485 ENOG4105CHR reductase HUT14_RS28490 ENOG4105VEQ Cold shock protein HUT14_RS28495 ENOG4105C1J atp-dependent rna helicase HUT14_RS28505 ENOG4105VEQ Cold shock protein HUT14_RS28510 ENOG4105CN5 Metallo-Beta-Lactamase HUT14_RS28515 ENOG4105BZG amino acid carrier protein HUT14_RS28535 ENOG4105VEQ Cold shock protein HUT14_RS28560 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUT14_RS28565 ENOG4105E8R UPF0173 metal-dependent hydrolase HUT14_RS28580 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HUT14_RS28585 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT14_RS28590 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT14_RS28615 ENOG4105C8Y Acetylornithine aminotransferase HUT14_RS28620 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HUT14_RS28630 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HUT14_RS28650 ENOG4108JQ7 (ABC) transporter HUT14_RS28665 ENOG4107QSI ABC, transporter HUT14_RS28675 ENOG4105I82 acetyl xylan esterase HUT14_RS28685 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT14_RS28695 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HUT14_RS28705 ENOG4105ECY inositol monophosphatase HUT14_RS28715 ENOG4108UVJ appr-1-p processing domain protein HUT14_RS28725 ENOG41066UM arsR family transcriptional regulator HUT14_RS28745 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUT14_RS28755 ENOG4105BZW Glycerate kinase HUT14_RS28770 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT14_RS28775 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS28785 ENOG4105CI0 Citrate lyase HUT14_RS28805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT14_RS28820 ENOG4106JDR secreted HUT14_RS28840 ENOG4108Q50 Histidine kinase HUT14_RS28850 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT14_RS28855 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT14_RS28860 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUT14_RS28865 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT14_RS28890 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT14_RS28905 ENOG4105DQE DNA ligase HUT14_RS28915 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HUT14_RS28940 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HUT14_RS28950 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HUT14_RS28965 ENOG4105C5H ABC transporter HUT14_RS28980 ENOG4108Z0Z intracellular protease Pfpi family HUT14_RS28985 ENOG41080XQ Signal transduction protein with cbs domains HUT14_RS29055 ENOG4105CFG Acts as a chaperone (By similarity) HUT14_RS29075 ENOG4106GCT Dehydratase HUT14_RS29085 ENOG4105CX8 fg-gap repeat protein HUT14_RS29100 ENOG4105CYP glycoside hydrolase, family HUT14_RS29105 ENOG41065HY 1,4-beta-cellobiosidase HUT14_RS29115 ENOG4105EMU Dehydrogenase HUT14_RS29120 ENOG4105CV8 reductase HUT14_RS29130 ENOG4105DUM transcriptional regulator, lysR family HUT14_RS29135 ENOG4105DHU Bile acid HUT14_RS29140 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT14_RS29155 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT14_RS29160 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HUT14_RS29175 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT14_RS29185 ENOG4105DKQ ROK family HUT14_RS29190 ENOG4105C2J ABC transporter HUT14_RS29195 ENOG4105CNN ABC, transporter HUT14_RS29200 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT14_RS29260 ENOG4105FCD Major Facilitator HUT14_RS29280 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT14_RS29290 ENOG4105C26 Dehydrogenase HUT14_RS29305 ENOG4105C4R Atp-dependent dna helicase HUT14_RS29350 ENOG4105CVR type I restriction-modification system HUT14_RS29405 ENOG4105CSH Transporter HUT14_RS29410 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT14_RS29415 ENOG4105EGE secreted protein HUT14_RS29470 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT14_RS29475 ENOG4105DEG Vwa containing coxe family protein HUT14_RS29505 ENOG4107YB1 Trehalose corynomycolyl transferase HUT14_RS29640 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT14_RS29660 ENOG4107QJN gtp cyclohydrolase ii HUT14_RS29670 ENOG410905P Pyridoxamine 5-phosphate HUT14_RS29675 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT14_RS29680 ENOG4105CSH Transporter HUT14_RS29685 ENOG4108W9H Tetr family transcriptional regulator HUT14_RS29690 ENOG4107S9B Shikimate dehydrogenase HUT14_RS29700 ENOG4107TB6 phosphoglycerate mutase HUT14_RS29705 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT14_RS29710 ENOG4107QP8 phosphohexose isomerase HUT14_RS29730 ENOG4107R13 MMPL domain protein HUT14_RS29735 ENOG4105WH1 Two component transcriptional regulator luxr family HUT14_RS29740 ENOG4105BZU Histidine kinase HUT14_RS29745 ENOG4105F8D glycoside hydrolase family 4 HUT14_RS29785 ENOG4108IJG ABC transporter substrate-binding protein HUT14_RS29790 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT14_RS29795 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT14_RS29800 ENOG4105CG3 alpha amylase, catalytic region HUT14_RS29810 ENOG4105CJA serine threonine protein kinase HUT14_RS29865 ENOG4107SM8 Adenylate Guanylate cyclase HUT14_RS29870 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUT14_RS29875 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT14_RS29880 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HUT14_RS29920 ENOG4105DQE DNA ligase HUT14_RS29940 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS29950 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT14_RS29965 ENOG4105C5H ABC transporter HUT14_RS29980 ENOG4105KF0 sporulation and cell division protein, SsgA HUT14_RS29995 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT14_RS30000 ENOG4105EG6 Saccharopine dehydrogenase HUT14_RS30010 ENOG410846T CoA-transferase family III HUT14_RS30015 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS30020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT14_RS30035 ENOG4105C94 Transporter HUT14_RS30050 ENOG4105C5H ABC transporter HUT14_RS30060 ENOG4105BZM domain protein HUT14_RS30080 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT14_RS30105 ENOG4108MDK Dehydrogenase HUT14_RS30125 ENOG4105EY8 ABC transporter HUT14_RS30130 ENOG4105FBD synthase HUT14_RS30140 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT14_RS30150 ENOG4105EWU Squalene--hopene cyclase HUT14_RS30165 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT14_RS30170 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT14_RS30205 ENOG41090WU lipolytic protein G-D-S-L family HUT14_RS30215 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HUT14_RS30245 ENOG4105CPQ Dehydrogenase HUT14_RS30250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT14_RS30255 ENOG4106NZI LysR family Transcriptional regulator HUT14_RS30260 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT14_RS30285 ENOG4105C1G acyl-Coa dehydrogenase HUT14_RS30330 ENOG4105KTE polyketide synthesis cyclase HUT14_RS30340 ENOG41079R3 acyl carrier protein HUT14_RS30395 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS30435 ENOG4105KJJ Uncharacterized ACR, COG1993 HUT14_RS30440 ENOG41083TI Protein CrcB homolog HUT14_RS30450 ENOG41073TP transcriptional regulator HUT14_RS30480 ENOG4105I82 acetyl xylan esterase HUT14_RS30505 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT14_RS30520 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT14_RS30550 ENOG4108UTZ Dihydroxyacetone kinase HUT14_RS30555 ENOG4105CMT Dihydroxyacetone kinase HUT14_RS30560 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT14_RS30575 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT14_RS30580 ENOG4105CTU Proline racemase HUT14_RS30585 ENOG4108WYP Transcriptional regulator HUT14_RS30590 ENOG4105CJW magnesium transporter HUT14_RS30615 ENOG41068KF Universal stress protein HUT14_RS30620 ENOG4107YZX Universal stress protein HUT14_RS30630 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT14_RS30635 ENOG4107VEG TrkA-N domain protein HUT14_RS30650 ENOG4106943 Heat shock protein HUT14_RS30680 ENOG4105E2A Dehydrogenase HUT14_RS30695 ENOG4105CPP Dehydrogenase, E1 component HUT14_RS30700 ENOG4108JYK Dehydrogenase HUT14_RS30755 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT14_RS30760 ENOG4105BZU Histidine kinase HUT14_RS30780 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT14_RS30825 ENOG4108IUE nitrate reductase beta subunit HUT14_RS30845 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUT14_RS30855 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT14_RS30950 ENOG4107S1E Beta-lactamase HUT14_RS31055 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT14_RS31060 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT14_RS31070 ENOG4108M0I Transcriptional regulator HUT14_RS31075 ENOG4105CPC Aldo Keto reductase HUT14_RS31110 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT14_RS31115 ENOG4105WBV Transcriptional regulator HUT14_RS31120 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT14_RS31125 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT14_RS31140 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT14_RS31145 ENOG4107SET aldo keto reductase HUT14_RS31175 ENOG4107QPV Serine Threonine protein kinase HUT14_RS31180 ENOG4105C7B Threonine dehydratase HUT14_RS31185 ENOG4105K4I Scp-like extracellular HUT14_RS31195 ENOG4105CUX Signal transduction histidine kinase HUT14_RS31215 ENOG4105C5X domain protein HUT14_RS31265 ENOG4105E8G Major facilitator Superfamily HUT14_RS31305 ENOG4105CEP NADH dehydrogenase HUT14_RS31320 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT14_RS31325 ENOG4105FUA antagonist HUT14_RS31330 ENOG4107MMM Anti-sigma-factor antagonist HUT14_RS31345 ENOG4105BZU Histidine kinase HUT14_RS31375 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT14_RS31380 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT14_RS31385 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HUT14_RS31395 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT14_RS31435 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT14_RS31445 ENOG4105DQE DNA ligase HUT14_RS31470 ENOG4105DQE DNA ligase HUT14_RS31475 ENOG4105CV8 reductase HUT14_RS31495 ENOG4107RTD sua5 ycio yrdc ywlc family protein HUT14_RS31505 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT14_RS31510 ENOG4105CH6 catalase HUT14_RS31535 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT14_RS31540 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT14_RS31545 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT14_RS31560 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT14_RS31565 ENOG4107E6A Cytochrome p-450 HUT14_RS31595 ENOG4106T9R serine protease HUT14_RS31600 ENOG4105DGI Alkaline phosphatase HUT14_RS31630 ENOG4105E2A Dehydrogenase HUT14_RS31640 ENOG4105CHH sulfate transporter HUT14_RS31660 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT14_RS31670 ENOG4107U9T Pfam:Ribonuclease_BN HUT14_RS31675 ENOG4108ZBR Gcn5-related n-acetyltransferase HUT14_RS31685 ENOG4107WA4 MmpL domain-containing protein HUT14_RS31720 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT14_RS31725 ENOG4105DRS transport system, permease HUT14_RS31750 ENOG4105CPC Aldo Keto reductase HUT14_RS31825 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT14_RS31855 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT14_RS31880 ENOG4105CSH Transporter HUT14_RS31915 ENOG4105NQG DoxX HUT14_RS31975 ENOG4108XEP Alpha Beta Hydrolase Fold protein HUT14_RS31980 ENOG4105KVH Transcriptional regulator HUT14_RS31990 ENOG4105CV8 reductase HUT14_RS32035 ENOG4105EMN RNA polymerase sigma factor HUT14_RS32045 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS32070 ENOG4105CEY Amp-dependent synthetase and ligase HUT14_RS32075 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT14_RS32080 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT14_RS32090 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT14_RS32095 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT14_RS32100 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT14_RS32105 ENOG4105CHR reductase HUT14_RS32110 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HUT14_RS32120 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT14_RS32185 ENOG4108VKG metal-dependent hydrolase HUT14_RS32190 ENOG4105DZR Type I site-specific deoxyribonuclease HUT14_RS32230 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT14_RS32590 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT14_RS32605 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT14_RS32610 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT14_RS32635 ENOG41087AY ADP-Ribose pyrophosphatase HUT14_RS32645 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT14_RS32665 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT14_RS32680 ENOG4105EUJ GTP cyclohydrolase i HUT14_RS32685 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HUT14_RS32690 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HUT14_RS32745 ENOG4105BZP glycoside hydrolase 15-related HUT14_RS32775 ENOG4105VF7 tolerance protein HUT14_RS32795 ENOG4105C26 Dehydrogenase HUT14_RS32800 ENOG4107RR1 TRANSCRIPTIONal HUT14_RS32810 ENOG4105EHG Permease protein HUT14_RS32815 ENOG4105E0A ABC, transporter HUT14_RS32825 ENOG4106UW1 Major Facilitator superfamily HUT14_RS32830 ENOG4108KPJ rna polymerase sigma factor HUT14_RS32840 ENOG4105E0A ABC, transporter HUT14_RS32845 ENOG4105CC5 ABC transporter HUT14_RS32855 ENOG4107XSR periplasmic solute binding protein HUT14_RS32895 ENOG4108Z6Z Transcriptional regulator HUT14_RS32930 ENOG4108N5B 2-phosphosulfolactate phosphatase HUT14_RS32945 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT14_RS32995 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT14_RS33015 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT14_RS33020 ENOG4105DYW oxidoreductase HUT14_RS33030 ENOG4105CHU acetyl-coa acetyltransferase HUT14_RS33035 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT14_RS33040 ENOG4108IQE Amp-dependent synthetase and ligase HUT14_RS33045 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT14_RS33060 ENOG4105I9Z UPF0264 protein HUT14_RS33080 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HUT14_RS33090 ENOG4106NZI LysR family Transcriptional regulator HUT14_RS33105 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT14_RS33110 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT14_RS33140 ENOG4108VQR secreted hydrolase HUT14_RS33170 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT14_RS33180 ENOG4105DXI Major Facilitator superfamily HUT14_RS33195 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT14_RS33225 ENOG4106NMR serine protease HUT14_RS33230 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT14_RS33240 ENOG4105D9P serine threonine protein kinase HUT14_RS33255 ENOG4105XEA Tetr family transcriptional regulator HUT14_RS33260 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT14_RS33275 ENOG4105C0X amino acid HUT14_RS33280 ENOG4105CRK lysyL-tRNA synthetase HUT14_RS33315 ENOG4105KVH Transcriptional regulator HUT14_RS33330 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUT14_RS33335 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HUT14_RS33340 ENOG4105C2J ABC transporter HUT14_RS33350 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT14_RS33355 ENOG4108RVA ribokinase HUT14_RS33420 ENOG4108JQ7 (ABC) transporter HUT14_RS33425 ENOG4105C3U ABC transporter HUT14_RS33430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT14_RS33440 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT14_RS33445 ENOG4105C5I Dehydrogenase HUT14_RS33450 ENOG4105EQX glucarate dehydratase HUT14_RS33455 ENOG4105C5I Dehydrogenase HUT14_RS33480 ENOG4107SET aldo keto reductase HUT14_RS33510 ENOG41068WN HUT14_RS33520 ENOG4105NRA 50s ribosomal protein l31 type b HUT14_RS33525 ENOG4105W0E 50S ribosomal protein L33 HUT14_RS33530 ENOG4105KDC 50s ribosomal protein l28 HUT14_RS33535 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT14_RS33540 ENOG4105NPE arsR family transcriptional regulator HUT14_RS33545 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HUT14_RS33625 ENOG4105KNA -acetyltransferase HUT14_RS33650 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT14_RS33665 ENOG4105ETE Transcriptional regulator (LacI family HUT14_RS33675 ENOG4107S5I aldo keto reductase HUT14_RS33695 ENOG4108762 serine threonine protein kinase HUT14_RS33745 ENOG4106A3M Cytochrome p-450 HUT14_RS33760 ENOG4107SQU synthase HUT14_RS33765 ENOG4107SQU synthase HUT14_RS33770 ENOG4107SQU synthase HUT14_RS33775 ENOG4107SQU synthase HUT14_RS33780 ENOG4107QKG PfaD family HUT14_RS33785 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUT14_RS33790 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HUT14_RS33795 ENOG4108MGH Enoyl-CoA hydratase HUT14_RS33800 ENOG4108KQ6 Enoyl-CoA hydratase HUT14_RS33805 ENOG41062T2 Acyl carrier protein HUT14_RS33810 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HUT14_RS33820 ENOG4105E0T Short-chain dehydrogenase reductase Sdr HUT14_RS33835 ENOG4107RDB Major Facilitator HUT14_RS33895 ENOG4107SHJ sulfite reductase subunit b HUT14_RS33920 ENOG410836F Transposase HUT14_RS34055 ENOG4108FPN Integrase