locus-tag	class	description
HUT15_RS00005	COG4585	Histidine kinase
HUT15_RS00010	COG2197	response regulator
HUT15_RS00040	COG2223	nitrite transmembrane transporter activity
HUT15_RS00045	COG2207	Transcriptional regulator
HUT15_RS00055	COG3655	Transcriptional regulator
HUT15_RS00060	COG0644	oxidoreductase
HUT15_RS00105	COG1819	glycosyl
HUT15_RS00110	COG0789	Transcriptional regulator
HUT15_RS00115	COG1051	belongs to the nudix hydrolase family
HUT15_RS00165	COG0243	molybdopterin cofactor binding
HUT15_RS00190	COG0542	response to heat
HUT15_RS00215	COG0483	inositol monophosphate 1-phosphatase activity
HUT15_RS00225	COG3226	Transcriptional regulator
HUT15_RS00230	COG0738	Major facilitator superfamily
HUT15_RS00250	COG0583	DNA-binding transcription factor activity
HUT15_RS00270	COG0583	DNA-binding transcription factor activity
HUT15_RS00290	COG0477	Major facilitator Superfamily
HUT15_RS00295	COG0531	amino acid
HUT15_RS00325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT15_RS00335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUT15_RS00340	COG3387	PFAM Glycoside hydrolase 15-related
HUT15_RS00345	COG0589	response to stress
HUT15_RS00350	COG0129	dihydroxy-acid dehydratase activity
HUT15_RS00360	COG1278	Cold shock
HUT15_RS00365	COG1132	(ABC) transporter
HUT15_RS00385	COG0753	catalase activity
HUT15_RS00395	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT15_RS00410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT15_RS00430	COG0367	asparagine synthase
HUT15_RS00465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT15_RS00480	COG4310	Domain of unknown function (DUF2172)
HUT15_RS00490	COG1215	transferase activity, transferring glycosyl groups
HUT15_RS00500	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HUT15_RS00505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT15_RS00535	COG2226	methyltransferase
HUT15_RS00540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT15_RS00560	COG1595	DNA-templated transcription, initiation
HUT15_RS00580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT15_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS00590	COG3321	synthase
HUT15_RS00590	COG0604	alcohol dehydrogenase
HUT15_RS00595	COG0460	homoserine dehydrogenase
HUT15_RS00625	COG0667	Aldo Keto reductase
HUT15_RS00650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUT15_RS00665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUT15_RS00675	COG1984	allophanate hydrolase subunit 2
HUT15_RS00705	COG0477	Major facilitator Superfamily
HUT15_RS00725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT15_RS00735	COG1175	transmembrane transport
HUT15_RS00740	COG0395	ABC-type sugar transport system, permease component
HUT15_RS00745	COG1609	Transcriptional regulator
HUT15_RS00755	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT15_RS00775	COG3290	protein histidine kinase activity
HUT15_RS00785	COG0346	lactoylglutathione lyase activity
HUT15_RS00790	COG0789	Transcriptional regulator
HUT15_RS00795	COG0659	secondary active sulfate transmembrane transporter activity
HUT15_RS00835	COG2382	esterase
HUT15_RS00845	COG1132	(ABC) transporter
HUT15_RS00855	COG1132	(ABC) transporter
HUT15_RS00865	COG1120	ATPase activity
HUT15_RS00870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT15_RS00875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT15_RS00880	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT15_RS00895	COG2936	dipeptidyl-peptidase activity
HUT15_RS00905	COG0513	Belongs to the DEAD box helicase family
HUT15_RS00915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUT15_RS00920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT15_RS00930	COG0666	response to abiotic stimulus
HUT15_RS00980	COG1140	nitrate reductase beta subunit
HUT15_RS00990	COG2181	nitrate reductase activity
HUT15_RS01010	COG1278	Cold shock
HUT15_RS01020	COG0673	inositol 2-dehydrogenase activity
HUT15_RS01025	COG2188	Transcriptional regulator
HUT15_RS01060	COG0395	ABC-type sugar transport system, permease component
HUT15_RS01065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT15_RS01080	COG0739	heme binding
HUT15_RS01100	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUT15_RS01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT15_RS01115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS01120	COG2340	Cysteine-rich secretory protein family
HUT15_RS01125	COG2205	protein histidine kinase activity
HUT15_RS01130	COG0745	RESPONSE REGULATOR receiver
HUT15_RS01155	COG0789	Transcriptional regulator
HUT15_RS01170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUT15_RS01200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUT15_RS01205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT15_RS01210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT15_RS01215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT15_RS01220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HUT15_RS01235	COG3340	Belongs to the peptidase S51 family
HUT15_RS01240	COG2124	cytochrome p450
HUT15_RS01260	COG2018	Roadblock/LC7 domain
HUT15_RS01285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUT15_RS01290	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT15_RS01295	COG0783	Belongs to the Dps family
HUT15_RS01315	COG1191	sigma factor activity
HUT15_RS01320	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT15_RS01345	COG0505	Belongs to the CarA family
HUT15_RS01385	COG2235	arginine
HUT15_RS01405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUT15_RS01420	COG1937	Protein conserved in bacteria
HUT15_RS01425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT15_RS01460	COG1233	COG1233 Phytoene dehydrogenase and related
HUT15_RS01465	COG1609	Transcriptional regulator
HUT15_RS01475	COG1595	DNA-templated transcription, initiation
HUT15_RS01490	COG0488	(ABC) transporter
HUT15_RS01500	COG1120	ATPase activity
HUT15_RS01505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT15_RS01535	COG3397	chitin binding
HUT15_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS01560	COG2264	protein methyltransferase activity
HUT15_RS01625	COG1175	transmembrane transport
HUT15_RS01630	COG0395	ABC-type sugar transport system, permease component
HUT15_RS01635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUT15_RS01660	COG0277	FAD linked oxidase domain protein
HUT15_RS01700	COG3290	protein histidine kinase activity
HUT15_RS01720	COG0477	Major facilitator Superfamily
HUT15_RS01725	COG3547	Transposase (IS116 IS110 IS902 family)
HUT15_RS01755	COG1295	ribonuclease BN
HUT15_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS01775	COG2080	2 iron, 2 sulfur cluster binding
HUT15_RS01780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT15_RS01785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT15_RS01825	COG1132	(ABC) transporter
HUT15_RS01875	COG0410	ABC transporter
HUT15_RS01880	COG2508	Transcriptional regulator
HUT15_RS01885	COG2197	response regulator
HUT15_RS01895	COG0673	inositol 2-dehydrogenase activity
HUT15_RS01975	COG1309	transcriptional regulator
HUT15_RS02005	COG1940	carbohydrate kinase activity
HUT15_RS02005	COG1846	Transcriptional regulator
HUT15_RS02010	COG1175	transmembrane transport
HUT15_RS02015	COG0395	ABC-type sugar transport system, permease component
HUT15_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS02055	COG1132	(ABC) transporter
HUT15_RS02100	COG0517	IMP dehydrogenase activity
HUT15_RS02130	COG2274	protein secretion by the type I secretion system
HUT15_RS02135	COG0248	Ppx GppA phosphatase
HUT15_RS02150	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT15_RS02165	COG1304	FMN binding
HUT15_RS02180	COG3250	beta-galactosidase activity
HUT15_RS02195	COG0667	Aldo Keto reductase
HUT15_RS02210	COG2124	cytochrome p450
HUT15_RS02225	COG0435	Glutathione S-transferase
HUT15_RS02255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT15_RS02270	COG1007	ATP synthesis coupled electron transport
HUT15_RS02275	COG1006	Multisubunit Na H antiporter MnhC subunit
HUT15_RS02315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT15_RS02315	COG1796	DNA polymerase
HUT15_RS02360	COG2706	6-phosphogluconolactonase activity
HUT15_RS02380	COG1357	PFAM Pentapeptide repeats (8 copies)
HUT15_RS02385	COG1595	DNA-templated transcription, initiation
HUT15_RS02400	COG1609	Transcriptional regulator
HUT15_RS02420	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT15_RS02425	COG1129	ABC transporter
HUT15_RS02430	COG4952	isomerase
HUT15_RS02435	COG3347	Dehydrogenase
HUT15_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS02440	COG1070	Carbohydrate kinase
HUT15_RS02445	COG0247	lactate metabolic process
HUT15_RS02450	COG1139	Iron-sulfur cluster binding protein
HUT15_RS02455	COG1556	Lactate utilization protein
HUT15_RS02460	COG0577	efflux transmembrane transporter activity
HUT15_RS02460	COG1136	(ABC) transporter
HUT15_RS02495	COG3540	Alkaline phosphatase
HUT15_RS02535	COG0668	transmembrane transport
HUT15_RS02550	COG2409	Drug exporters of the RND superfamily
HUT15_RS02555	COG1846	Transcriptional regulator
HUT15_RS02560	COG0702	epimerase
HUT15_RS02590	COG0604	alcohol dehydrogenase
HUT15_RS02610	COG0800	Aldolase
HUT15_RS02660	COG0242	peptide deformylase activity
HUT15_RS02665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT15_RS02670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT15_RS02675	COG1609	Transcriptional regulator
HUT15_RS02690	COG0583	DNA-binding transcription factor activity
HUT15_RS02710	COG3976	FMN-binding domain protein
HUT15_RS02710	COG1053	succinate dehydrogenase
HUT15_RS02715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT15_RS02725	COG0517	IMP dehydrogenase activity
HUT15_RS02740	COG0596	Alpha beta hydrolase
HUT15_RS02775	COG3572	ergothioneine biosynthetic process
HUT15_RS02780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT15_RS02785	COG0121	glutamine amidotransferase
HUT15_RS02790	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUT15_RS02795	COG2182	Extracellular solute-binding protein
HUT15_RS02800	COG3360	Dodecin
HUT15_RS02810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT15_RS02835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT15_RS02840	COG1053	succinate dehydrogenase
HUT15_RS02850	COG0583	DNA-binding transcription factor activity
HUT15_RS02860	COG0583	DNA-binding transcription factor activity
HUT15_RS02900	COG0726	polysaccharide deacetylase
HUT15_RS02910	COG0531	amino acid
HUT15_RS02915	COG2267	carboxylic ester hydrolase activity
HUT15_RS02945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT15_RS02970	COG0395	ABC-type sugar transport system, permease component
HUT15_RS02975	COG1175	transmembrane transport
HUT15_RS02985	COG1609	Transcriptional regulator
HUT15_RS03020	COG3537	Alpha-1,2-mannosidase
HUT15_RS03030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUT15_RS03035	COG0297	glycogen (starch) synthase activity
HUT15_RS03055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUT15_RS03070	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT15_RS03115	COG0517	IMP dehydrogenase activity
HUT15_RS03115	COG0516	GMP reductase activity
HUT15_RS03170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT15_RS03170	COG0574	Belongs to the PEP-utilizing enzyme family
HUT15_RS03180	COG1063	alcohol dehydrogenase
HUT15_RS03185	COG0589	response to stress
HUT15_RS03215	COG0745	RESPONSE REGULATOR receiver
HUT15_RS03220	COG2205	protein histidine kinase activity
HUT15_RS03240	COG0702	epimerase
HUT15_RS03255	COG0142	geranyltranstransferase activity
HUT15_RS03275	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HUT15_RS03310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT15_RS03325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUT15_RS03330	COG0569	domain protein
HUT15_RS03505	COG4585	Histidine kinase
HUT15_RS03510	COG2201	protein-glutamate methylesterase activity
HUT15_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS03565	COG1169	isochorismate synthase
HUT15_RS03580	COG4106	trans-aconitate 2-methyltransferase activity
HUT15_RS03585	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HUT15_RS03590	COG2124	cytochrome p450
HUT15_RS03595	COG4106	trans-aconitate 2-methyltransferase activity
HUT15_RS03605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT15_RS03605	COG2226	methyltransferase
HUT15_RS03605	COG3433	isochorismatase activity
HUT15_RS03610	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HUT15_RS03610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT15_RS03615	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT15_RS03620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT15_RS03625	COG4171	peptide transport system, permease
HUT15_RS03630	COG0601	transmembrane transport
HUT15_RS03655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT15_RS03660	COG1120	ATPase activity
HUT15_RS03665	COG1609	Transcriptional regulator
HUT15_RS03680	COG2233	PERMEase
HUT15_RS03725	COG1874	Beta-galactosidase
HUT15_RS03725	COG0366	Alpha amylase catalytic
HUT15_RS03750	COG1653	transport
HUT15_RS03755	COG1175	transmembrane transport
HUT15_RS03760	COG0395	ABC-type sugar transport system, permease component
HUT15_RS03765	COG0366	Alpha amylase catalytic
HUT15_RS03775	COG1132	(ABC) transporter
HUT15_RS03795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT15_RS03805	COG0531	amino acid
HUT15_RS03810	COG0668	transmembrane transport
HUT15_RS03815	COG2838	Isocitrate dehydrogenase
HUT15_RS03830	COG2124	cytochrome p450
HUT15_RS03845	COG1404	Belongs to the peptidase S8 family
HUT15_RS03855	COG2197	response regulator
HUT15_RS03870	COG0385	Bile acid
HUT15_RS03875	COG0673	inositol 2-dehydrogenase activity
HUT15_RS03880	COG0702	epimerase
HUT15_RS03885	COG3631	Ketosteroid isomerase-related protein
HUT15_RS03895	COG1609	Transcriptional regulator
HUT15_RS03905	COG0673	inositol 2-dehydrogenase activity
HUT15_RS03910	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HUT15_RS03935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT15_RS03945	COG3718	enzyme involved in inositol metabolism
HUT15_RS03950	COG3962	Belongs to the TPP enzyme family
HUT15_RS03955	COG2188	Transcriptional regulator
HUT15_RS04005	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS04015	COG0183	Belongs to the thiolase family
HUT15_RS04020	COG2267	carboxylic ester hydrolase activity
HUT15_RS04045	COG0174	glutamine synthetase
HUT15_RS04085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT15_RS04085	COG2111	Na H antiporter
HUT15_RS04115	COG0583	DNA-binding transcription factor activity
HUT15_RS04120	COG0156	8-amino-7-oxononanoate synthase activity
HUT15_RS04125	COG1063	alcohol dehydrogenase
HUT15_RS04170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT15_RS04185	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT15_RS04200	COG2755	lipolytic protein G-D-S-L family
HUT15_RS04230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT15_RS04235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT15_RS04250	COG1657	PFAM Prenyltransferase squalene oxidase
HUT15_RS04260	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT15_RS04270	COG1562	ergosterol biosynthetic process
HUT15_RS04275	COG1134	teichoic acid transport
HUT15_RS04315	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT15_RS04325	COG1024	Enoyl-CoA hydratase
HUT15_RS04345	COG2183	response to ionizing radiation
HUT15_RS04350	COG0488	(ABC) transporter
HUT15_RS04360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT15_RS04375	COG1113	amino acid transport
HUT15_RS04385	COG1024	Enoyl-CoA hydratase
HUT15_RS04385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT15_RS04390	COG0183	Belongs to the thiolase family
HUT15_RS04395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT15_RS04400	COG3268	Saccharopine dehydrogenase
HUT15_RS04415	COG1515	deoxyribonuclease V activity
HUT15_RS04445	COG0488	(ABC) transporter
HUT15_RS04450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT15_RS04455	COG1834	amidinotransferase
HUT15_RS04500	COG1793	dna ligase
HUT15_RS04510	COG1470	cell adhesion involved in biofilm formation
HUT15_RS04530	COG0183	Belongs to the thiolase family
HUT15_RS04535	COG3485	protocatechuate 3,4-dioxygenase
HUT15_RS04540	COG3485	protocatechuate 3,4-dioxygenase
HUT15_RS04545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT15_RS04550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT15_RS04580	COG3511	phospholipase C
HUT15_RS04585	COG0477	Major facilitator Superfamily
HUT15_RS04600	COG2197	response regulator
HUT15_RS04605	COG1132	(ABC) transporter
HUT15_RS04610	COG1132	(ABC) transporter
HUT15_RS04620	COG0515	serine threonine protein kinase
HUT15_RS04670	COG1486	melibiose metabolic process
HUT15_RS04685	COG2197	response regulator
HUT15_RS04690	COG2409	Drug exporters of the RND superfamily
HUT15_RS04710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT15_RS04725	COG0166	Belongs to the GPI family
HUT15_RS04730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT15_RS04745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT15_RS04765	COG0297	glycogen (starch) synthase activity
HUT15_RS04780	COG1183	phosphatidylcholine synthase activity
HUT15_RS04795	COG0747	negative chemotaxis
HUT15_RS04820	COG0210	DNA helicase
HUT15_RS04825	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUT15_RS04825	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUT15_RS04940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT15_RS04945	COG0515	serine threonine protein kinase
HUT15_RS04950	COG0515	serine threonine protein kinase
HUT15_RS04955	COG0827	DNA restriction-modification system
HUT15_RS04990	COG3340	Belongs to the peptidase S51 family
HUT15_RS05015	COG1733	regulation of RNA biosynthetic process
HUT15_RS05045	COG1733	regulation of RNA biosynthetic process
HUT15_RS05060	COG4632	Exopolysaccharide biosynthesis protein
HUT15_RS05060	COG5434	Belongs to the glycosyl hydrolase 28 family
HUT15_RS05080	COG2723	6-phospho-beta-galactosidase activity
HUT15_RS05085	COG0395	ABC-type sugar transport system, permease component
HUT15_RS05090	COG1175	transmembrane transport
HUT15_RS05095	COG2182	Extracellular solute-binding protein
HUT15_RS05100	COG1940	carbohydrate kinase activity
HUT15_RS05140	COG0129	dihydroxy-acid dehydratase activity
HUT15_RS05150	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT15_RS05160	COG1175	transmembrane transport
HUT15_RS05170	COG1609	Transcriptional regulator
HUT15_RS05175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT15_RS05190	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS05200	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT15_RS05210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT15_RS05220	COG2223	nitrite transmembrane transporter activity
HUT15_RS05275	COG0673	inositol 2-dehydrogenase activity
HUT15_RS05285	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT15_RS05290	COG1129	ABC transporter
HUT15_RS05305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT15_RS05320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUT15_RS05325	COG3383	formate dehydrogenase (NAD+) activity
HUT15_RS05330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUT15_RS05340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUT15_RS05345	COG1846	Transcriptional regulator
HUT15_RS05370	COG0477	Major facilitator Superfamily
HUT15_RS05380	COG0656	L-ascorbic acid biosynthetic process
HUT15_RS05385	COG4221	oxidoreductase activity
HUT15_RS05395	COG5297	Belongs to the glycosyl hydrolase family 6
HUT15_RS05400	COG4733	cellulase activity
HUT15_RS05400	COG5297	Belongs to the glycosyl hydrolase family 6
HUT15_RS05415	COG3401	FG-GAP repeat protein
HUT15_RS05425	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT15_RS05455	COG1140	nitrate reductase beta subunit
HUT15_RS05490	COG0531	amino acid
HUT15_RS05545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT15_RS05555	COG0693	protein deglycase activity
HUT15_RS05570	COG0488	(ABC) transporter
HUT15_RS05575	COG1597	lipid kinase activity
HUT15_RS05640	COG3285	dna ligase
HUT15_RS05640	COG1793	dna ligase
HUT15_RS05655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT15_RS05685	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT15_RS05690	COG1506	peptidase
HUT15_RS05690	COG0823	Involved in the tonB-independent uptake of proteins
HUT15_RS05690	COG4946	Tricorn protease homolog
HUT15_RS05695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT15_RS05700	COG2362	D-Aminopeptidase
HUT15_RS05740	COG0596	Alpha beta hydrolase
HUT15_RS05770	COG0604	alcohol dehydrogenase
HUT15_RS05775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS05775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS05780	COG2301	Belongs to the HpcH HpaI aldolase family
HUT15_RS05790	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS05795	COG0688	phosphatidylethanolamine metabolic process
HUT15_RS05805	COG1929	Belongs to the glycerate kinase type-1 family
HUT15_RS05815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT15_RS05825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT15_RS05840	COG0640	Transcriptional regulator
HUT15_RS05860	COG0444	Belongs to the ABC transporter superfamily
HUT15_RS05865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT15_RS05870	COG0601	transmembrane transport
HUT15_RS05880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HUT15_RS05890	COG0483	inositol monophosphate 1-phosphatase activity
HUT15_RS05905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT15_RS05915	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS05920	COG1891	lyase activity
HUT15_RS05930	COG4585	Histidine kinase
HUT15_RS05940	COG2197	response regulator
HUT15_RS05960	COG1953	Uracil, thiamine, allantoin
HUT15_RS05965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT15_RS05970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT15_RS05985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT15_RS06010	COG0405	Gamma-glutamyltransferase
HUT15_RS06030	COG0154	amidase activity
HUT15_RS06045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT15_RS06050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT15_RS06060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT15_RS06100	COG5297	Belongs to the glycosyl hydrolase family 6
HUT15_RS06100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUT15_RS06105	COG1482	cell wall glycoprotein biosynthetic process
HUT15_RS06110	COG1940	carbohydrate kinase activity
HUT15_RS06115	COG1609	Transcriptional regulator
HUT15_RS06120	COG3250	beta-galactosidase activity
HUT15_RS06130	COG1175	transmembrane transport
HUT15_RS06135	COG3833	ABC-type maltose transport systems, permease component
HUT15_RS06175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT15_RS06200	COG1132	(ABC) transporter
HUT15_RS06205	COG1132	(ABC) transporter
HUT15_RS06235	COG1509	lysine 2,3-aminomutase activity
HUT15_RS06260	COG0673	inositol 2-dehydrogenase activity
HUT15_RS06265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT15_RS06270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT15_RS06290	COG3173	Aminoglycoside phosphotransferase
HUT15_RS06335	COG4104	PAAR repeat-containing protein
HUT15_RS06335	COG3209	COG3209 Rhs family protein
HUT15_RS06345	COG1115	amino acid carrier protein
HUT15_RS06355	COG1032	radical SAM domain protein
HUT15_RS06360	COG0437	4 iron, 4 sulfur cluster binding
HUT15_RS06380	COG3383	formate dehydrogenase (NAD+) activity
HUT15_RS06380	COG0243	molybdopterin cofactor binding
HUT15_RS06385	COG0243	molybdopterin cofactor binding
HUT15_RS06385	COG3383	formate dehydrogenase (NAD+) activity
HUT15_RS06390	COG0709	Synthesizes selenophosphate from selenide and ATP
HUT15_RS06420	COG3246	L-lysine catabolic process to acetate
HUT15_RS06425	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT15_RS06435	COG0277	FAD linked oxidase domain protein
HUT15_RS06435	COG0247	lactate metabolic process
HUT15_RS06445	COG1132	(ABC) transporter
HUT15_RS06450	COG1802	Transcriptional regulator
HUT15_RS06455	COG3938	Belongs to the proline racemase family
HUT15_RS06460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT15_RS06465	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT15_RS06470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT15_RS06470	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT15_RS06475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT15_RS06485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT15_RS06495	COG1940	carbohydrate kinase activity
HUT15_RS06515	COG2188	Transcriptional regulator
HUT15_RS06520	COG0673	inositol 2-dehydrogenase activity
HUT15_RS06525	COG2197	response regulator
HUT15_RS06545	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS06550	COG4266	Belongs to the allantoicase family
HUT15_RS06555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT15_RS06560	COG1414	Transcriptional regulator
HUT15_RS06590	COG0346	lactoylglutathione lyase activity
HUT15_RS06605	COG4264	IucA IucC family
HUT15_RS06630	COG0406	alpha-ribazole phosphatase activity
HUT15_RS06645	COG2233	PERMEase
HUT15_RS06655	COG2233	PERMEase
HUT15_RS06665	COG2351	hydroxyisourate hydrolase activity
HUT15_RS06685	COG3622	Belongs to the hyi family
HUT15_RS06690	COG2084	Dehydrogenase
HUT15_RS06695	COG0753	catalase activity
HUT15_RS06710	COG3960	tartronate-semialdehyde synthase activity
HUT15_RS06720	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS06725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT15_RS06730	COG2197	response regulator
HUT15_RS06745	COG4249	Peptidase C14 caspase catalytic subunit p20
HUT15_RS06745	COG2319	Wd-40 repeat
HUT15_RS06785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT15_RS06785	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT15_RS06790	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT15_RS06795	COG0297	glycogen (starch) synthase activity
HUT15_RS06805	COG0859	PFAM glycosyl transferase family 9
HUT15_RS06820	COG2192	nodulation
HUT15_RS06830	COG0726	polysaccharide deacetylase
HUT15_RS06850	COG2252	PERMEase
HUT15_RS06855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT15_RS06870	COG3835	regulator
HUT15_RS06900	COG3851	Histidine kinase
HUT15_RS06905	COG2197	response regulator
HUT15_RS06915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT15_RS06920	COG1802	Transcriptional regulator
HUT15_RS06940	COG0028	Belongs to the TPP enzyme family
HUT15_RS06960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT15_RS06970	COG1162	GTPase activity
HUT15_RS06975	COG4585	Histidine kinase
HUT15_RS06980	COG2197	response regulator
HUT15_RS06995	COG1131	(ABC) transporter
HUT15_RS07005	COG0277	FAD linked oxidase domain protein
HUT15_RS07040	COG2197	response regulator
HUT15_RS07045	COG4585	Histidine kinase
HUT15_RS07055	COG2040	homocysteine
HUT15_RS07065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT15_RS07070	COG0473	3-isopropylmalate dehydrogenase activity
HUT15_RS07070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT15_RS07080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT15_RS07085	COG0583	DNA-binding transcription factor activity
HUT15_RS07090	COG2814	Major facilitator Superfamily
HUT15_RS07095	COG1942	4-Oxalocrotonate Tautomerase
HUT15_RS07100	COG0583	DNA-binding transcription factor activity
HUT15_RS07130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUT15_RS07135	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT15_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS07150	COG1063	alcohol dehydrogenase
HUT15_RS07160	COG2814	Major facilitator Superfamily
HUT15_RS07175	COG0714	Associated with various cellular activities
HUT15_RS07190	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT15_RS07255	COG3142	Participates in the control of copper homeostasis
HUT15_RS07265	COG1846	Transcriptional regulator
HUT15_RS07265	COG1940	carbohydrate kinase activity
HUT15_RS07305	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS07325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT15_RS07335	COG0175	sulfate reduction
HUT15_RS07340	COG0529	Catalyzes the synthesis of activated sulfate
HUT15_RS07365	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HUT15_RS07370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT15_RS07395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT15_RS07465	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT15_RS07470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUT15_RS07485	COG3173	Aminoglycoside phosphotransferase
HUT15_RS07495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUT15_RS07515	COG1309	transcriptional regulator
HUT15_RS07550	COG1174	glycine betaine transport
HUT15_RS07555	COG1174	glycine betaine transport
HUT15_RS07565	COG0745	RESPONSE REGULATOR receiver
HUT15_RS07570	COG2205	protein histidine kinase activity
HUT15_RS07575	COG2226	methyltransferase
HUT15_RS07575	COG3433	isochorismatase activity
HUT15_RS07575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT15_RS07580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT15_RS07660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT15_RS07665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUT15_RS07695	COG0723	plastoquinol--plastocyanin reductase activity
HUT15_RS07695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT15_RS07715	COG3220	belongs to the UPF0276 family
HUT15_RS07745	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT15_RS07785	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT15_RS07790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUT15_RS07805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUT15_RS07810	COG0183	Belongs to the thiolase family
HUT15_RS07815	COG1024	Enoyl-CoA hydratase
HUT15_RS07815	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT15_RS07820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT15_RS07825	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS07835	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS07840	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS07845	COG1316	TRANSCRIPTIONal
HUT15_RS07865	COG0531	amino acid
HUT15_RS07870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT15_RS07875	COG3979	chitinase
HUT15_RS07880	COG4214	carbohydrate transport
HUT15_RS07890	COG4213	ABC transporter substrate-binding protein
HUT15_RS07895	COG1940	carbohydrate kinase activity
HUT15_RS07900	COG0395	ABC-type sugar transport system, permease component
HUT15_RS07905	COG1175	transmembrane transport
HUT15_RS07910	COG1653	transport
HUT15_RS07945	COG0395	ABC-type sugar transport system, permease component
HUT15_RS07950	COG4209	transmembrane transport
HUT15_RS07955	COG3458	cephalosporin-C deacetylase activity
HUT15_RS07965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUT15_RS07975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT15_RS08010	COG0395	ABC-type sugar transport system, permease component
HUT15_RS08015	COG1175	transmembrane transport
HUT15_RS08025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT15_RS08030	COG1349	DNA-binding transcription factor activity
HUT15_RS08035	COG0785	Cytochrome C biogenesis protein
HUT15_RS08040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT15_RS08040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT15_RS08110	COG1024	Enoyl-CoA hydratase
HUT15_RS08120	COG0531	amino acid
HUT15_RS08125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT15_RS08130	COG2235	arginine
HUT15_RS08135	COG0475	glutathione-regulated potassium exporter activity
HUT15_RS08140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT15_RS08170	COG1799	cell septum assembly
HUT15_RS08175	COG0247	lactate metabolic process
HUT15_RS08175	COG0277	FAD linked oxidase domain protein
HUT15_RS08190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT15_RS08200	COG0310	cobalt ion transport
HUT15_RS08205	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HUT15_RS08215	COG1122	ATPase activity
HUT15_RS08235	COG0477	Major facilitator Superfamily
HUT15_RS08250	COG2205	protein histidine kinase activity
HUT15_RS08255	COG0745	RESPONSE REGULATOR receiver
HUT15_RS08265	COG2409	Drug exporters of the RND superfamily
HUT15_RS08275	COG2814	Major facilitator Superfamily
HUT15_RS08290	COG1309	transcriptional regulator
HUT15_RS08295	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS08305	COG0456	acetyltransferase
HUT15_RS08310	COG1309	transcriptional regulator
HUT15_RS08320	COG3693	PFAM glycoside hydrolase, family 10
HUT15_RS08335	COG3654	unkown
HUT15_RS08375	COG3291	Pkd domain containing protein
HUT15_RS08410	COG3654	unkown
HUT15_RS08420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT15_RS08425	COG0531	amino acid
HUT15_RS08450	COG0500	methyltransferase
HUT15_RS08460	COG1088	dTDP-glucose 4,6-dehydratase activity
HUT15_RS08470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT15_RS08475	COG0156	8-amino-7-oxononanoate synthase activity
HUT15_RS08480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS08485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT15_RS08490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS08500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT15_RS08530	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS08545	COG3629	intracellular signal transduction
HUT15_RS08550	COG0569	domain protein
HUT15_RS08580	COG1136	(ABC) transporter
HUT15_RS08580	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUT15_RS08590	COG0756	dUTP diphosphatase activity
HUT15_RS08615	COG2205	protein histidine kinase activity
HUT15_RS08620	COG0745	RESPONSE REGULATOR receiver
HUT15_RS08675	COG1435	thymidine kinase activity
HUT15_RS08695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT15_RS08700	COG1802	Transcriptional regulator
HUT15_RS08715	COG0612	Peptidase, M16
HUT15_RS08720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT15_RS08725	COG0523	cobalamin synthesis protein
HUT15_RS08740	COG0372	Belongs to the citrate synthase family
HUT15_RS08755	COG3290	protein histidine kinase activity
HUT15_RS08760	COG4565	transcriptional regulatory protein
HUT15_RS08765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT15_RS08775	COG0187	DNA topoisomerase II activity
HUT15_RS08790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT15_RS08795	COG2186	Transcriptional regulator
HUT15_RS08830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT15_RS08850	COG0588	phosphoglycerate mutase activity
HUT15_RS08865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT15_RS08870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUT15_RS08875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUT15_RS08910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUT15_RS08920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT15_RS08925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUT15_RS08935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUT15_RS08955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT15_RS08960	COG4733	cellulase activity
HUT15_RS08960	COG5297	Belongs to the glycosyl hydrolase family 6
HUT15_RS08965	COG2197	response regulator
HUT15_RS08970	COG3851	Histidine kinase
HUT15_RS08995	COG2205	protein histidine kinase activity
HUT15_RS09000	COG0745	RESPONSE REGULATOR receiver
HUT15_RS09005	COG1126	abc transporter atp-binding protein
HUT15_RS09010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT15_RS09015	COG0765	amino acid transport
HUT15_RS09020	COG0765	amino acid transport
HUT15_RS09035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT15_RS09045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUT15_RS09055	COG0628	permease
HUT15_RS09080	COG2207	Transcriptional regulator
HUT15_RS09080	COG1917	Cupin 2, conserved barrel domain protein
HUT15_RS09085	COG1201	RNA secondary structure unwinding
HUT15_RS09090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT15_RS09110	COG0783	Belongs to the Dps family
HUT15_RS09115	COG1396	sequence-specific DNA binding
HUT15_RS09120	COG1058	Belongs to the CinA family
HUT15_RS09120	COG1546	Belongs to the CinA family
HUT15_RS09130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT15_RS09140	COG1674	ftsk spoiiie
HUT15_RS09150	COG0784	Response regulator, receiver
HUT15_RS09150	COG2205	protein histidine kinase activity
HUT15_RS09155	COG2208	phosphoserine phosphatase activity
HUT15_RS09155	COG2770	Histidine kinase
HUT15_RS09185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT15_RS09190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT15_RS09195	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUT15_RS09215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT15_RS09220	COG0612	Peptidase, M16
HUT15_RS09225	COG1185	polyribonucleotide nucleotidyltransferase activity
HUT15_RS09230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUT15_RS09250	COG1674	ftsk spoiiie
HUT15_RS09265	COG1404	Belongs to the peptidase S8 family
HUT15_RS09320	COG3266	domain, Protein
HUT15_RS09335	COG0455	bacterial-type flagellum organization
HUT15_RS09340	COG0747	negative chemotaxis
HUT15_RS09345	COG0601	transmembrane transport
HUT15_RS09360	COG4608	Belongs to the ABC transporter superfamily
HUT15_RS09375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUT15_RS09380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUT15_RS09390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUT15_RS09405	COG0779	Required for maturation of 30S ribosomal subunits
HUT15_RS09425	COG0442	prolyl-tRNA aminoacylation
HUT15_RS09440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT15_RS09445	COG0750	zinc metalloprotease
HUT15_RS09450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUT15_RS09480	COG0395	ABC-type sugar transport system, permease component
HUT15_RS09485	COG4209	transmembrane transport
HUT15_RS09500	COG2197	response regulator
HUT15_RS09515	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS09520	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS09525	COG2508	Transcriptional regulator
HUT15_RS09560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT15_RS09565	COG1177	transmembrane transport
HUT15_RS09575	COG3842	ATPase activity
HUT15_RS09605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT15_RS09630	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS09640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT15_RS09675	COG3842	ATPase activity
HUT15_RS09680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HUT15_RS09690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUT15_RS09775	COG0575	Belongs to the CDS family
HUT15_RS09780	COG0233	cytoplasmic translational termination
HUT15_RS09785	COG0528	UMP kinase activity
HUT15_RS09790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUT15_RS09795	COG0052	Belongs to the universal ribosomal protein uS2 family
HUT15_RS09800	COG4942	peptidase
HUT15_RS09810	COG1191	sigma factor activity
HUT15_RS09825	COG0792	nuclease activity
HUT15_RS09845	COG0681	Belongs to the peptidase S26 family
HUT15_RS09860	COG0335	large ribosomal subunit rRNA binding
HUT15_RS09865	COG0336	Belongs to the RNA methyltransferase TrmD family
HUT15_RS09870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUT15_RS09875	COG1837	Belongs to the UPF0109 family
HUT15_RS09880	COG0228	four-way junction DNA binding
HUT15_RS09905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT15_RS09940	COG0477	Major facilitator Superfamily
HUT15_RS09955	COG1254	Belongs to the acylphosphatase family
HUT15_RS09965	COG1733	regulation of RNA biosynthetic process
HUT15_RS09970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT15_RS09975	COG0571	ribonuclease III activity
HUT15_RS09980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUT15_RS09995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUT15_RS10000	COG0742	ribosomal rna small subunit methyltransferase
HUT15_RS10015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT15_RS10025	COG0351	phosphomethylpyrimidine kinase
HUT15_RS10040	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT15_RS10045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT15_RS10055	COG1920	GTP binding
HUT15_RS10065	COG0776	regulation of translation
HUT15_RS10075	COG0066	3-isopropylmalate dehydratase activity
HUT15_RS10080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT15_RS10085	COG1414	Transcriptional regulator
HUT15_RS10135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUT15_RS10140	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT15_RS10150	COG5002	protein histidine kinase activity
HUT15_RS10155	COG2018	Roadblock/LC7 domain
HUT15_RS10175	COG2018	Roadblock/LC7 domain
HUT15_RS10195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT15_RS10200	COG5492	domain, Protein
HUT15_RS10205	COG2353	YceI-like domain
HUT15_RS10210	COG1335	isochorismatase
HUT15_RS10230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT15_RS10240	COG2957	Belongs to the agmatine deiminase family
HUT15_RS10245	COG0804	urea catabolic process
HUT15_RS10250	COG0832	Belongs to the urease beta subunit family
HUT15_RS10250	COG0831	urea catabolic process
HUT15_RS10260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT15_RS10265	COG0473	3-isopropylmalate dehydrogenase activity
HUT15_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS10275	COG0506	proline dehydrogenase activity
HUT15_RS10290	COG0477	Major facilitator Superfamily
HUT15_RS10295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT15_RS10300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT15_RS10305	COG0440	acetolactate synthase activity
HUT15_RS10315	COG5001	Diguanylate cyclase
HUT15_RS10325	COG0667	Aldo Keto reductase
HUT15_RS10330	COG2133	pyrroloquinoline quinone binding
HUT15_RS10340	COG2197	response regulator
HUT15_RS10355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT15_RS10360	COG2409	Drug exporters of the RND superfamily
HUT15_RS10365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT15_RS10375	COG0154	amidase activity
HUT15_RS10380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT15_RS10405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT15_RS10415	COG4221	oxidoreductase activity
HUT15_RS10420	COG1611	Belongs to the LOG family
HUT15_RS10435	COG0482	sulfurtransferase activity
HUT15_RS10460	COG1309	transcriptional regulator
HUT15_RS10470	COG0789	Transcriptional regulator
HUT15_RS10480	COG2860	membrane
HUT15_RS10485	COG4608	Belongs to the ABC transporter superfamily
HUT15_RS10490	COG0444	Belongs to the ABC transporter superfamily
HUT15_RS10525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT15_RS10530	COG0509	glycine decarboxylation via glycine cleavage system
HUT15_RS10535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT15_RS10540	COG1760	l-serine dehydratase
HUT15_RS10550	COG0277	FAD linked oxidase domain protein
HUT15_RS10555	COG1045	serine acetyltransferase
HUT15_RS10575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT15_RS10580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT15_RS10590	COG0151	Belongs to the GarS family
HUT15_RS10595	COG0431	NADPH-dependent FMN reductase
HUT15_RS10610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT15_RS10625	COG1063	alcohol dehydrogenase
HUT15_RS10645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT15_RS10650	COG2223	nitrite transmembrane transporter activity
HUT15_RS10655	COG0243	molybdopterin cofactor binding
HUT15_RS10665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT15_RS10665	COG2146	nitrite reductase [NAD(P)H] activity
HUT15_RS10680	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT15_RS10690	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT15_RS10705	COG1959	2 iron, 2 sulfur cluster binding
HUT15_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS10765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT15_RS10765	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS10765	COG3321	synthase
HUT15_RS10765	COG0300	oxidoreductase activity
HUT15_RS10770	COG2207	Transcriptional regulator
HUT15_RS10775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT15_RS10790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT15_RS10805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT15_RS10825	COG0583	DNA-binding transcription factor activity
HUT15_RS10840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT15_RS10845	COG1309	transcriptional regulator
HUT15_RS10865	COG3467	pyridoxamine 5'-phosphate
HUT15_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS10875	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS10875	COG0300	oxidoreductase activity
HUT15_RS10875	COG3321	synthase
HUT15_RS10875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT15_RS10915	COG0789	Transcriptional regulator
HUT15_RS10940	COG1376	ErfK ybiS ycfS ynhG family protein
HUT15_RS10955	COG2197	response regulator
HUT15_RS10960	COG4585	Histidine kinase
HUT15_RS10970	COG1131	(ABC) transporter
HUT15_RS10975	COG1132	(ABC) transporter
HUT15_RS10980	COG1132	(ABC) transporter
HUT15_RS10985	COG1132	(ABC) transporter
HUT15_RS10990	COG1132	(ABC) transporter
HUT15_RS11010	COG0058	SHG alpha-glucan phosphorylase activity
HUT15_RS11015	COG0366	Alpha amylase catalytic
HUT15_RS11020	COG0366	Alpha amylase catalytic
HUT15_RS11025	COG3281	Trehalose synthase
HUT15_RS11030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUT15_RS11040	COG3118	belongs to the thioredoxin family
HUT15_RS11050	COG1301	dicarboxylic acid transport
HUT15_RS11055	COG3290	protein histidine kinase activity
HUT15_RS11060	COG4565	transcriptional regulatory protein
HUT15_RS11070	COG1653	transport
HUT15_RS11080	COG0395	ABC-type sugar transport system, permease component
HUT15_RS11095	COG0667	Aldo Keto reductase
HUT15_RS11105	COG0205	6-phosphofructokinase activity
HUT15_RS11110	COG0280	phosphate acetyltransferase
HUT15_RS11110	COG0857	belongs to the CobB CobQ family
HUT15_RS11115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUT15_RS11150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS11150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS11195	COG2205	protein histidine kinase activity
HUT15_RS11200	COG0745	RESPONSE REGULATOR receiver
HUT15_RS11220	COG0183	Belongs to the thiolase family
HUT15_RS11240	COG1131	(ABC) transporter
HUT15_RS11280	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUT15_RS11295	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT15_RS11340	COG2197	response regulator
HUT15_RS11355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUT15_RS11360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUT15_RS11365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUT15_RS11370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUT15_RS11375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT15_RS11380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUT15_RS11385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT15_RS11400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT15_RS11405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT15_RS11410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT15_RS11420	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT15_RS11425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUT15_RS11430	COG0254	rRNA binding
HUT15_RS11435	COG1316	TRANSCRIPTIONal
HUT15_RS11450	COG0083	homoserine kinase activity
HUT15_RS11455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT15_RS11460	COG0460	homoserine dehydrogenase
HUT15_RS11465	COG0019	diaminopimelate decarboxylase activity
HUT15_RS11470	COG0018	arginyl-trna synthetase
HUT15_RS11470	COG0018	arginyl-trna synthetase
HUT15_RS11475	COG0745	RESPONSE REGULATOR receiver
HUT15_RS11540	COG2188	Transcriptional regulator
HUT15_RS11550	COG2188	Transcriptional regulator
HUT15_RS11625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT15_RS11635	COG1733	regulation of RNA biosynthetic process
HUT15_RS11645	COG1683	Conserved Protein
HUT15_RS11665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT15_RS11670	COG2329	Antibiotic biosynthesis monooxygenase
HUT15_RS11675	COG0662	Cupin 2, conserved barrel domain protein
HUT15_RS11680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT15_RS11685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT15_RS11690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS11695	COG2867	negative regulation of translational initiation
HUT15_RS11710	COG3467	pyridoxamine 5'-phosphate
HUT15_RS11725	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT15_RS11730	COG3285	dna ligase
HUT15_RS11730	COG1793	dna ligase
HUT15_RS11750	COG2205	protein histidine kinase activity
HUT15_RS11790	COG3883	PFAM NLP P60 protein
HUT15_RS11790	COG0791	NLP P60 protein
HUT15_RS11835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT15_RS11845	COG0745	RESPONSE REGULATOR receiver
HUT15_RS11850	COG2205	protein histidine kinase activity
HUT15_RS11855	COG0567	Dehydrogenase, E1 component
HUT15_RS11855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT15_RS11920	COG0542	response to heat
HUT15_RS11930	COG0604	alcohol dehydrogenase
HUT15_RS11935	COG0281	malic enzyme
HUT15_RS11950	COG1126	abc transporter atp-binding protein
HUT15_RS11955	COG4106	trans-aconitate 2-methyltransferase activity
HUT15_RS11990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT15_RS12030	COG1597	lipid kinase activity
HUT15_RS12055	COG0363	glucosamine-6-phosphate deaminase activity
HUT15_RS12060	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT15_RS12065	COG0395	ABC-type sugar transport system, permease component
HUT15_RS12070	COG1175	transmembrane transport
HUT15_RS12075	COG2182	Extracellular solute-binding protein
HUT15_RS12080	COG2188	Transcriptional regulator
HUT15_RS12115	COG2124	cytochrome p450
HUT15_RS12125	COG0242	peptide deformylase activity
HUT15_RS12145	COG5662	AntiSigma factor
HUT15_RS12150	COG1595	DNA-templated transcription, initiation
HUT15_RS12160	COG2135	peptidase activity
HUT15_RS12170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT15_RS12180	COG2076	Multidrug Resistance protein
HUT15_RS12190	COG0483	inositol monophosphate 1-phosphatase activity
HUT15_RS12200	COG0753	catalase activity
HUT15_RS12225	COG1615	UPF0182 protein
HUT15_RS12235	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT15_RS12290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT15_RS12320	COG2816	NAD+ diphosphatase activity
HUT15_RS12330	COG0210	DNA helicase
HUT15_RS12355	COG0596	Alpha beta hydrolase
HUT15_RS12420	COG0513	Belongs to the DEAD box helicase family
HUT15_RS12430	COG1432	Conserved Protein
HUT15_RS12440	COG2095	MarC family integral membrane protein
HUT15_RS12445	COG0613	PHP domain protein
HUT15_RS12455	COG2814	Major facilitator Superfamily
HUT15_RS12465	COG0598	Magnesium transport protein CorA
HUT15_RS12500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT15_RS12515	COG1595	DNA-templated transcription, initiation
HUT15_RS12530	COG1024	Enoyl-CoA hydratase
HUT15_RS12535	COG0519	Catalyzes the synthesis of GMP from XMP
HUT15_RS12545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT15_RS12555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT15_RS12600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT15_RS12625	COG4608	Belongs to the ABC transporter superfamily
HUT15_RS12630	COG0444	Belongs to the ABC transporter superfamily
HUT15_RS12640	COG0601	transmembrane transport
HUT15_RS12655	COG0747	negative chemotaxis
HUT15_RS12665	COG0444	Belongs to the ABC transporter superfamily
HUT15_RS12670	COG4608	Belongs to the ABC transporter superfamily
HUT15_RS12675	COG4608	Belongs to the ABC transporter superfamily
HUT15_RS12680	COG0444	Belongs to the ABC transporter superfamily
HUT15_RS12685	COG0601	transmembrane transport
HUT15_RS12690	COG0747	negative chemotaxis
HUT15_RS12720	COG1053	succinate dehydrogenase
HUT15_RS12725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT15_RS12775	COG0300	oxidoreductase activity
HUT15_RS12780	COG0583	DNA-binding transcription factor activity
HUT15_RS12790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT15_RS12815	COG2264	protein methyltransferase activity
HUT15_RS12835	COG0012	GTP binding
HUT15_RS12850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT15_RS12860	COG1570	exodeoxyribonuclease VII activity
HUT15_RS12865	COG1722	exodeoxyribonuclease VII activity
HUT15_RS12875	COG0778	Nitroreductase
HUT15_RS12900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT15_RS12900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT15_RS12910	COG0114	fumarate hydratase activity
HUT15_RS12925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT15_RS12945	COG1136	(ABC) transporter
HUT15_RS12960	COG0450	alkyl hydroperoxide reductase
HUT15_RS12965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT15_RS12975	COG0741	lytic transglycosylase activity
HUT15_RS12980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUT15_RS12985	COG2226	methyltransferase
HUT15_RS13055	COG2894	cell division
HUT15_RS13100	COG2610	gluconate transmembrane transporter activity
HUT15_RS13105	COG0251	oxidation-reduction process
HUT15_RS13110	COG1414	Transcriptional regulator
HUT15_RS13125	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUT15_RS13130	COG0436	Aminotransferase
HUT15_RS13140	COG2267	carboxylic ester hydrolase activity
HUT15_RS13145	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUT15_RS13165	COG1331	Highly conserved protein containing a thioredoxin domain
HUT15_RS13170	COG0590	tRNA wobble adenosine to inosine editing
HUT15_RS13180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT15_RS13190	COG2255	four-way junction helicase activity
HUT15_RS13200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT15_RS13210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT15_RS13225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT15_RS13255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT15_RS13285	COG0667	Aldo Keto reductase
HUT15_RS13300	COG1140	nitrate reductase beta subunit
HUT15_RS13310	COG1090	epimerase
HUT15_RS13315	COG1064	alcohol dehydrogenase
HUT15_RS13340	COG1595	DNA-templated transcription, initiation
HUT15_RS13350	COG1136	(ABC) transporter
HUT15_RS13375	COG2986	histidine ammonia-lyase
HUT15_RS13385	COG1024	Enoyl-CoA hydratase
HUT15_RS13395	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT15_RS13405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT15_RS13415	COG0424	maF-like protein
HUT15_RS13425	COG4770	biotin carboxylase activity
HUT15_RS13450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT15_RS13465	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS13475	COG0515	serine threonine protein kinase
HUT15_RS13500	COG1595	DNA-templated transcription, initiation
HUT15_RS13505	COG0745	RESPONSE REGULATOR receiver
HUT15_RS13510	COG2205	protein histidine kinase activity
HUT15_RS13535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT15_RS13540	COG1959	2 iron, 2 sulfur cluster binding
HUT15_RS13545	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS13555	COG0583	DNA-binding transcription factor activity
HUT15_RS13560	COG2814	Major facilitator Superfamily
HUT15_RS13625	COG1744	ABC transporter substrate-binding protein PnrA-like
HUT15_RS13630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT15_RS13630	COG1473	amidohydrolase
HUT15_RS13640	COG2089	acid synthase
HUT15_RS13655	COG1216	Glycosyl transferase, family 2
HUT15_RS13670	COG0463	Glycosyl transferase, family 2
HUT15_RS13700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS13700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS13715	COG1595	DNA-templated transcription, initiation
HUT15_RS13725	COG1595	DNA-templated transcription, initiation
HUT15_RS13755	COG2009	succinate dehydrogenase
HUT15_RS13765	COG1053	succinate dehydrogenase
HUT15_RS13795	COG1309	transcriptional regulator
HUT15_RS13800	COG1408	metallophosphoesterase
HUT15_RS13830	COG0671	phosphoesterase, PA-phosphatase related
HUT15_RS13850	COG0180	Tryptophanyl-tRNA synthetase
HUT15_RS13860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT15_RS13865	COG0754	glutathionylspermidine amidase activity
HUT15_RS13875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT15_RS13880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT15_RS13885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT15_RS13890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUT15_RS13900	COG4176	ABC-type proline glycine betaine transport system permease component
HUT15_RS13905	COG0517	IMP dehydrogenase activity
HUT15_RS13905	COG4175	Glycine betaine
HUT15_RS13915	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS13920	COG0039	L-malate dehydrogenase activity
HUT15_RS13935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT15_RS13950	COG0515	serine threonine protein kinase
HUT15_RS13950	COG2815	serine threonine protein kinase
HUT15_RS13965	COG2815	serine threonine protein kinase
HUT15_RS13965	COG0515	serine threonine protein kinase
HUT15_RS13975	COG0138	bifunctional purine biosynthesis protein purh
HUT15_RS14005	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT15_RS14015	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUT15_RS14025	COG0714	Associated with various cellular activities
HUT15_RS14040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS14040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT15_RS14050	COG0739	heme binding
HUT15_RS14080	COG2197	response regulator
HUT15_RS14115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT15_RS14115	COG0519	Catalyzes the synthesis of GMP from XMP
HUT15_RS14135	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS14140	COG0515	serine threonine protein kinase
HUT15_RS14150	COG0515	serine threonine protein kinase
HUT15_RS14155	COG0515	serine threonine protein kinase
HUT15_RS14155	COG2815	serine threonine protein kinase
HUT15_RS14175	COG0516	GMP reductase activity
HUT15_RS14185	COG1595	DNA-templated transcription, initiation
HUT15_RS14200	COG0583	DNA-binding transcription factor activity
HUT15_RS14210	COG4221	oxidoreductase activity
HUT15_RS14230	COG1280	lysine exporter protein (LysE YggA)
HUT15_RS14240	COG0459	protein refolding
HUT15_RS14245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT15_RS14250	COG0726	polysaccharide deacetylase
HUT15_RS14255	COG0726	polysaccharide deacetylase
HUT15_RS14265	COG4941	Belongs to the sigma-70 factor family
HUT15_RS14290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUT15_RS14290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT15_RS14310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT15_RS14320	COG0456	acetyltransferase
HUT15_RS14320	COG1214	PFAM Peptidase M22, glycoprotease
HUT15_RS14335	COG0802	atpase or kinase
HUT15_RS14345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT15_RS14350	COG0736	holo-[acyl-carrier-protein] synthase activity
HUT15_RS14370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT15_RS14380	COG1072	(Pantothenic acid kinase))
HUT15_RS14395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT15_RS14400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUT15_RS14405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUT15_RS14420	COG0101	tRNA pseudouridine synthase activity
HUT15_RS14425	COG0203	ribosomal protein L17
HUT15_RS14435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUT15_RS14440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUT15_RS14445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT15_RS14450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUT15_RS14460	COG0563	adenylate kinase activity
HUT15_RS14465	COG0201	protein transport
HUT15_RS14470	COG0200	Binds to the 23S rRNA
HUT15_RS14475	COG1841	ribosomal large subunit assembly
HUT15_RS14480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUT15_RS14485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUT15_RS14490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUT15_RS14495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUT15_RS14500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT15_RS14505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUT15_RS14510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUT15_RS14515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUT15_RS14520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUT15_RS14525	COG0255	Belongs to the universal ribosomal protein uL29 family
HUT15_RS14530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUT15_RS14535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUT15_RS14540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUT15_RS14545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUT15_RS14550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUT15_RS14555	COG0089	rRNA binding
HUT15_RS14560	COG0088	Forms part of the polypeptide exit tunnel
HUT15_RS14565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUT15_RS14570	COG0051	transcription antitermination factor activity, RNA binding
HUT15_RS14610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT15_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS14670	COG0583	DNA-binding transcription factor activity
HUT15_RS14700	COG2197	response regulator
HUT15_RS14710	COG1136	(ABC) transporter
HUT15_RS14725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT15_RS14730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT15_RS14735	COG0049	tRNA binding
HUT15_RS14740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUT15_RS14860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUT15_RS14865	COG0085	RNA polymerase activity
HUT15_RS14870	COG0222	ribosome binding
HUT15_RS14875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUT15_RS14890	COG0081	regulation of translation
HUT15_RS14895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUT15_RS14900	COG0250	Participates in transcription elongation, termination and antitermination
HUT15_RS14905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT15_RS14915	COG0436	Aminotransferase
HUT15_RS14920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT15_RS14935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUT15_RS14945	COG0477	Major facilitator Superfamily
HUT15_RS14970	COG2030	dehydratase
HUT15_RS14975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT15_RS14990	COG0402	S-adenosylhomocysteine deaminase activity
HUT15_RS14995	COG0702	epimerase
HUT15_RS15005	COG1666	GTP binding
HUT15_RS15010	COG2261	transglycosylase associated protein
HUT15_RS15020	COG3304	Inner membrane component domain
HUT15_RS15025	COG0501	Belongs to the peptidase M48B family
HUT15_RS15030	COG1007	ATP synthesis coupled electron transport
HUT15_RS15040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT15_RS15045	COG0713	ATP synthesis coupled electron transport
HUT15_RS15055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT15_RS15065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT15_RS15095	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT15_RS15100	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT15_RS15105	COG0702	epimerase
HUT15_RS15150	COG0739	heme binding
HUT15_RS15150	COG1196	nuclear chromosome segregation
HUT15_RS15150	COG0741	lytic transglycosylase activity
HUT15_RS15225	COG1131	(ABC) transporter
HUT15_RS15245	COG0561	phosphatase activity
HUT15_RS15260	COG0514	ATP-dependent DNA helicase (RecQ)
HUT15_RS15270	COG1007	ATP synthesis coupled electron transport
HUT15_RS15280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT15_RS15285	COG0713	ATP synthesis coupled electron transport
HUT15_RS15290	COG0839	Belongs to the complex I subunit 6 family
HUT15_RS15295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT15_RS15305	COG1034	ATP synthesis coupled electron transport
HUT15_RS15310	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUT15_RS15320	COG0649	NAD binding
HUT15_RS15325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15345	COG0242	peptide deformylase activity
HUT15_RS15365	COG2226	methyltransferase
HUT15_RS15395	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT15_RS15415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT15_RS15415	COG0515	serine threonine protein kinase
HUT15_RS15420	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT15_RS15430	COG2226	methyltransferase
HUT15_RS15455	COG1309	transcriptional regulator
HUT15_RS15460	COG1301	dicarboxylic acid transport
HUT15_RS15475	COG1573	uracil-dna glycosylase
HUT15_RS15480	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT15_RS15490	COG0163	prenyltransferase activity
HUT15_RS15495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUT15_RS15500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUT15_RS15570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUT15_RS15575	COG1333	cytochrome c biogenesis protein
HUT15_RS15580	COG0785	Cytochrome C biogenesis protein
HUT15_RS15585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT15_RS15595	COG0406	alpha-ribazole phosphatase activity
HUT15_RS15600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT15_RS15610	COG1278	Cold shock
HUT15_RS15615	COG0596	Alpha beta hydrolase
HUT15_RS15635	COG0492	ferredoxin-NADP+ reductase activity
HUT15_RS15640	COG0640	Transcriptional regulator
HUT15_RS15645	COG0798	PFAM Bile acid sodium symporter
HUT15_RS15655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT15_RS15665	COG1007	ATP synthesis coupled electron transport
HUT15_RS15680	COG0713	ATP synthesis coupled electron transport
HUT15_RS15690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT15_RS15700	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT15_RS15765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT15_RS15770	COG1742	UPF0060 membrane protein
HUT15_RS15785	COG1690	Belongs to the RtcB family
HUT15_RS15805	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUT15_RS15810	COG0018	arginyl-trna synthetase
HUT15_RS15815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT15_RS15835	COG0113	porphobilinogen synthase activity
HUT15_RS15855	COG1063	alcohol dehydrogenase
HUT15_RS15870	COG1648	precorrin-2 dehydrogenase activity
HUT15_RS15870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT15_RS15875	COG0181	hydroxymethylbilane synthase activity
HUT15_RS15880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUT15_RS15885	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUT15_RS15935	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUT15_RS15945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT15_RS15965	COG0180	Tryptophanyl-tRNA synthetase
HUT15_RS15980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUT15_RS15990	COG0842	Transport permease protein
HUT15_RS15990	COG1129	ABC transporter
HUT15_RS16015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT15_RS16015	COG0515	serine threonine protein kinase
HUT15_RS16020	COG0129	dihydroxy-acid dehydratase activity
HUT15_RS16030	COG1082	Xylose isomerase domain protein TIM barrel
HUT15_RS16035	COG0248	Ppx GppA phosphatase
HUT15_RS16055	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUT15_RS16065	COG1194	a g-specific adenine glycosylase
HUT15_RS16070	COG1595	DNA-templated transcription, initiation
HUT15_RS16080	COG0745	RESPONSE REGULATOR receiver
HUT15_RS16085	COG2205	protein histidine kinase activity
HUT15_RS16095	COG0346	lactoylglutathione lyase activity
HUT15_RS16130	COG0739	heme binding
HUT15_RS16170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT15_RS16190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT15_RS16200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT15_RS16205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT15_RS16230	COG1660	Displays ATPase and GTPase activities
HUT15_RS16250	COG0649	NAD binding
HUT15_RS16290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUT15_RS16310	COG0302	gtp cyclohydrolase
HUT15_RS16325	COG0037	tRNA processing
HUT15_RS16335	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT15_RS16340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT15_RS16350	COG0586	Pfam SNARE associated Golgi protein
HUT15_RS16355	COG0789	Transcriptional regulator
HUT15_RS16370	COG0076	glutamate decarboxylase activity
HUT15_RS16390	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS16410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT15_RS16420	COG0254	rRNA binding
HUT15_RS16425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT15_RS16430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT15_RS16435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT15_RS16455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT15_RS16455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT15_RS16470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT15_RS16485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUT15_RS16490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT15_RS16495	COG1754	DNA topoisomerase type I activity
HUT15_RS16495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUT15_RS16515	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUT15_RS16520	COG2172	sigma factor antagonist activity
HUT15_RS16525	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT15_RS16530	COG1205	dead DEAH box helicase
HUT15_RS16530	COG1111	helicase
HUT15_RS16590	COG0659	secondary active sulfate transmembrane transporter activity
HUT15_RS16595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT15_RS16600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT15_RS16610	COG2267	carboxylic ester hydrolase activity
HUT15_RS16625	COG0494	nUDIX hydrolase
HUT15_RS16640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT15_RS16650	COG0596	Alpha beta hydrolase
HUT15_RS16670	COG0003	Pfam Anion-transporting ATPase
HUT15_RS16680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT15_RS16700	COG1408	metallophosphoesterase
HUT15_RS16725	COG0659	secondary active sulfate transmembrane transporter activity
HUT15_RS16730	COG0640	Transcriptional regulator
HUT15_RS16735	COG2824	Alkylphosphonate utilization operon protein PhnA
HUT15_RS16740	COG1309	transcriptional regulator
HUT15_RS16760	COG2205	protein histidine kinase activity
HUT15_RS16765	COG0745	RESPONSE REGULATOR receiver
HUT15_RS16775	COG1234	tRNA 3'-trailer cleavage
HUT15_RS16785	COG0475	glutathione-regulated potassium exporter activity
HUT15_RS16835	COG1595	DNA-templated transcription, initiation
HUT15_RS16870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUT15_RS16875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT15_RS16895	COG1802	Transcriptional regulator
HUT15_RS16910	COG1595	DNA-templated transcription, initiation
HUT15_RS16925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT15_RS16945	COG1131	(ABC) transporter
HUT15_RS16950	COG3559	Exporter of polyketide antibiotics
HUT15_RS16975	COG2197	response regulator
HUT15_RS16985	COG2197	response regulator
HUT15_RS16990	COG4585	Histidine kinase
HUT15_RS17010	COG3844	kynureninase activity
HUT15_RS17025	COG0477	Major facilitator Superfamily
HUT15_RS17030	COG0191	fructose-bisphosphate aldolase activity
HUT15_RS17035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUT15_RS17055	COG4585	Histidine kinase
HUT15_RS17060	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUT15_RS17085	COG0542	response to heat
HUT15_RS17115	COG2197	response regulator
HUT15_RS17125	COG1136	(ABC) transporter
HUT15_RS17135	COG4213	ABC transporter substrate-binding protein
HUT15_RS17140	COG0789	Transcriptional regulator
HUT15_RS17145	COG0484	heat shock protein binding
HUT15_RS17150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUT15_RS17155	COG0443	Heat shock 70 kDa protein
HUT15_RS17160	COG2181	nitrate reductase activity
HUT15_RS17160	COG0247	lactate metabolic process
HUT15_RS17185	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUT15_RS17190	COG0717	Belongs to the dCTP deaminase family
HUT15_RS17225	COG1309	transcriptional regulator
HUT15_RS17230	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS17250	COG1252	NADH dehydrogenase
HUT15_RS17255	COG1595	DNA-templated transcription, initiation
HUT15_RS17260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUT15_RS17270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUT15_RS17345	COG1278	Cold shock
HUT15_RS17350	COG0513	Belongs to the DEAD box helicase family
HUT15_RS17385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT15_RS17390	COG5002	protein histidine kinase activity
HUT15_RS17395	COG0745	RESPONSE REGULATOR receiver
HUT15_RS17410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT15_RS17440	COG1136	(ABC) transporter
HUT15_RS17440	COG0577	efflux transmembrane transporter activity
HUT15_RS17455	COG1136	(ABC) transporter
HUT15_RS17455	COG0577	efflux transmembrane transporter activity
HUT15_RS17460	COG2197	response regulator
HUT15_RS17465	COG4585	Histidine kinase
HUT15_RS17515	COG0583	DNA-binding transcription factor activity
HUT15_RS17540	COG1957	nucleoside hydrolase
HUT15_RS17545	COG0366	Alpha amylase catalytic
HUT15_RS17610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT15_RS17620	COG0326	Molecular chaperone. Has ATPase activity
HUT15_RS17655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUT15_RS17670	COG1741	Belongs to the pirin family
HUT15_RS17680	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS17685	COG1362	aminopeptidase activity
HUT15_RS17720	COG2186	Transcriptional regulator
HUT15_RS17745	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT15_RS17750	COG0022	dehydrogenase e1 component
HUT15_RS17770	COG0515	serine threonine protein kinase
HUT15_RS17775	COG0515	serine threonine protein kinase
HUT15_RS17790	COG3321	synthase
HUT15_RS17790	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS17790	COG0604	alcohol dehydrogenase
HUT15_RS17800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT15_RS17830	COG1522	sequence-specific DNA binding
HUT15_RS17835	COG1309	transcriptional regulator
HUT15_RS17840	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT15_RS17890	COG1716	ATPase activity
HUT15_RS17895	COG1716	ATPase activity
HUT15_RS17910	COG0768	penicillin binding
HUT15_RS17915	COG0515	serine threonine protein kinase
HUT15_RS17925	COG3764	Sortase (surface protein transpeptidase)
HUT15_RS17930	COG3764	Sortase (surface protein transpeptidase)
HUT15_RS17955	COG0705	Rhomboid family
HUT15_RS17970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT15_RS17985	COG0515	serine threonine protein kinase
HUT15_RS18030	COG4249	Peptidase C14 caspase catalytic subunit p20
HUT15_RS18030	COG2319	Wd-40 repeat
HUT15_RS18050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT15_RS18055	COG0187	DNA topoisomerase II activity
HUT15_RS18065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT15_RS18070	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT15_RS18075	COG0592	DNA-directed DNA polymerase activity
HUT15_RS18080	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUT15_RS18085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUT15_RS18090	COG0594	ribonuclease P activity
HUT15_RS18095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT15_RS18100	COG0706	membrane insertase activity
HUT15_RS18110	COG0357	Ribosomal RNA small subunit methyltransferase G
HUT15_RS18115	COG1192	Involved in chromosome partitioning
HUT15_RS18130	COG3118	belongs to the thioredoxin family
HUT15_RS18135	COG0492	ferredoxin-NADP+ reductase activity
HUT15_RS18145	COG1595	DNA-templated transcription, initiation
HUT15_RS18165	COG0617	tRNA 3'-terminal CCA addition
HUT15_RS18195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT15_RS18220	COG0360	Binds together with S18 to 16S ribosomal RNA
HUT15_RS18225	COG0629	single-stranded DNA binding
HUT15_RS18230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT15_RS18235	COG0359	binds to the 23S rRNA
HUT15_RS18245	COG0305	Participates in initiation and elongation during chromosome replication
HUT15_RS18265	COG2814	Major facilitator Superfamily
HUT15_RS18290	COG0626	cystathionine gamma-synthase activity
HUT15_RS18295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT15_RS18300	COG1950	PFAM Membrane protein of
HUT15_RS18305	COG0662	Cupin 2, conserved barrel domain protein
HUT15_RS18330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUT15_RS18355	COG1609	Transcriptional regulator
HUT15_RS18360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT15_RS18370	COG1271	oxidase subunit
HUT15_RS18375	COG1294	oxidase, subunit
HUT15_RS18380	COG4988	ABC transporter
HUT15_RS18390	COG0739	heme binding
HUT15_RS18395	COG0561	phosphatase activity
HUT15_RS18410	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUT15_RS18420	COG1131	(ABC) transporter
HUT15_RS18440	COG0561	phosphatase activity
HUT15_RS18445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT15_RS18450	COG0077	Prephenate dehydratase
HUT15_RS18455	COG2837	iron assimilation
HUT15_RS18470	COG1999	signal sequence binding
HUT15_RS18490	COG0006	proline dipeptidase activity
HUT15_RS18510	COG0653	protein targeting
HUT15_RS18525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT15_RS18535	COG1309	transcriptional regulator
HUT15_RS18635	COG0789	Transcriptional regulator
HUT15_RS18650	COG1595	DNA-templated transcription, initiation
HUT15_RS18655	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS18660	COG2814	Major facilitator Superfamily
HUT15_RS18665	COG1309	transcriptional regulator
HUT15_RS18695	COG0768	penicillin binding
HUT15_RS18700	COG1733	regulation of RNA biosynthetic process
HUT15_RS18715	COG0745	RESPONSE REGULATOR receiver
HUT15_RS18720	COG2205	protein histidine kinase activity
HUT15_RS18730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUT15_RS18740	COG3467	pyridoxamine 5'-phosphate
HUT15_RS18765	COG0477	Major facilitator Superfamily
HUT15_RS18780	COG1191	sigma factor activity
HUT15_RS18785	COG1191	sigma factor activity
HUT15_RS18820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUT15_RS18985	COG0151	Belongs to the GarS family
HUT15_RS19000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUT15_RS19010	COG2197	response regulator
HUT15_RS19045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT15_RS19050	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT15_RS19055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT15_RS19090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT15_RS19120	COG1643	Atp-dependent helicase
HUT15_RS19155	COG0513	Belongs to the DEAD box helicase family
HUT15_RS19190	COG1473	amidohydrolase
HUT15_RS19195	COG2860	membrane
HUT15_RS19200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT15_RS19200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT15_RS19230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUT15_RS19240	COG0579	oxidoreductase
HUT15_RS19270	COG1252	NADH dehydrogenase
HUT15_RS19285	COG1846	Transcriptional regulator
HUT15_RS19305	COG2197	response regulator
HUT15_RS19310	COG4585	Histidine kinase
HUT15_RS19350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT15_RS19370	COG1196	nuclear chromosome segregation
HUT15_RS19370	COG0741	lytic transglycosylase activity
HUT15_RS19370	COG0739	heme binding
HUT15_RS19375	COG0671	phosphoesterase, PA-phosphatase related
HUT15_RS19380	COG0277	FAD linked oxidase domain protein
HUT15_RS19395	COG1937	Protein conserved in bacteria
HUT15_RS19405	COG0306	phosphate transporter
HUT15_RS19410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT15_RS19440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUT15_RS19470	COG0456	acetyltransferase
HUT15_RS19475	COG0737	Belongs to the 5'-nucleotidase family
HUT15_RS19480	COG1733	regulation of RNA biosynthetic process
HUT15_RS19495	COG0745	RESPONSE REGULATOR receiver
HUT15_RS19500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT15_RS19505	COG1609	Transcriptional regulator
HUT15_RS19510	COG0745	RESPONSE REGULATOR receiver
HUT15_RS19535	COG2897	thiosulfate sulfurtransferase activity
HUT15_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS19590	COG3485	protocatechuate 3,4-dioxygenase
HUT15_RS19595	COG0735	belongs to the Fur family
HUT15_RS19600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT15_RS19605	COG1490	D-aminoacyl-tRNA deacylase activity
HUT15_RS19620	COG4552	Acetyltransferase involved in intracellular survival and related
HUT15_RS19635	COG2188	Transcriptional regulator
HUT15_RS19645	COG0546	phosphoglycolate phosphatase activity
HUT15_RS19695	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS19720	COG0588	phosphoglycerate mutase activity
HUT15_RS19745	COG2188	Transcriptional regulator
HUT15_RS19775	COG2207	Transcriptional regulator
HUT15_RS19775	COG3708	Transcriptional regulator
HUT15_RS19805	COG5002	protein histidine kinase activity
HUT15_RS19820	COG1329	Transcriptional regulator
HUT15_RS19825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUT15_RS19830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUT15_RS19835	COG0215	cysteine-tRNA ligase activity
HUT15_RS19860	COG3842	ATPase activity
HUT15_RS19870	COG0596	Alpha beta hydrolase
HUT15_RS19960	COG0464	growth
HUT15_RS19975	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT15_RS19975	COG1672	PFAM Archaeal ATPase
HUT15_RS20025	COG1309	transcriptional regulator
HUT15_RS20035	COG0494	nUDIX hydrolase
HUT15_RS20055	COG2197	response regulator
HUT15_RS20100	COG1940	carbohydrate kinase activity
HUT15_RS20125	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT15_RS20135	COG0463	Glycosyl transferase, family 2
HUT15_RS20150	COG1278	Cold shock
HUT15_RS20155	COG0459	protein refolding
HUT15_RS20195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUT15_RS20200	COG1737	Transcriptional regulator
HUT15_RS20240	COG3973	AAA domain
HUT15_RS20250	COG1061	Type III restriction enzyme res subunit
HUT15_RS20280	COG1278	Cold shock
HUT15_RS20285	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT15_RS20290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT15_RS20300	COG2814	Major facilitator Superfamily
HUT15_RS20315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT15_RS20325	COG2252	PERMEase
HUT15_RS20355	COG0667	Aldo Keto reductase
HUT15_RS20400	COG2197	response regulator
HUT15_RS20465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUT15_RS20470	COG0277	FAD linked oxidase domain protein
HUT15_RS20470	COG0247	lactate metabolic process
HUT15_RS20515	COG2188	Transcriptional regulator
HUT15_RS20520	COG2226	methyltransferase
HUT15_RS20530	COG1733	regulation of RNA biosynthetic process
HUT15_RS20535	COG0596	Alpha beta hydrolase
HUT15_RS20540	COG2318	DinB family
HUT15_RS20570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT15_RS20570	COG0515	serine threonine protein kinase
HUT15_RS20585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT15_RS20600	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS20620	COG0259	pyridoxamine-phosphate oxidase activity
HUT15_RS20640	COG4821	SIS domain
HUT15_RS20650	COG0596	Alpha beta hydrolase
HUT15_RS20650	COG2945	thiolester hydrolase activity
HUT15_RS20660	COG1131	(ABC) transporter
HUT15_RS20720	COG1595	DNA-templated transcription, initiation
HUT15_RS20725	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT15_RS20745	COG2271	Major facilitator Superfamily
HUT15_RS20755	COG2072	flavoprotein involved in K transport
HUT15_RS20765	COG0259	pyridoxamine-phosphate oxidase activity
HUT15_RS20775	COG1309	transcriptional regulator
HUT15_RS20800	COG3903	Transcriptional regulator
HUT15_RS20800	COG3629	intracellular signal transduction
HUT15_RS20820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT15_RS20885	COG1686	Belongs to the peptidase S11 family
HUT15_RS20910	COG0386	Belongs to the glutathione peroxidase family
HUT15_RS20935	COG0110	maltose O-acetyltransferase activity
HUT15_RS20940	COG4257	antibiotic catabolic process
HUT15_RS20945	COG1309	transcriptional regulator
HUT15_RS20950	COG0477	Major facilitator Superfamily
HUT15_RS20955	COG4941	Belongs to the sigma-70 factor family
HUT15_RS20960	COG3795	YCII-related domain
HUT15_RS20975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT15_RS20990	COG4585	Histidine kinase
HUT15_RS20995	COG2197	response regulator
HUT15_RS21015	COG2188	Transcriptional regulator
HUT15_RS21035	COG1414	Transcriptional regulator
HUT15_RS21055	COG1846	Transcriptional regulator
HUT15_RS21060	COG3384	dioxygenase
HUT15_RS21065	COG1247	-acetyltransferase
HUT15_RS21070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT15_RS21085	COG0477	Major facilitator Superfamily
HUT15_RS21090	COG1349	DNA-binding transcription factor activity
HUT15_RS21100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT15_RS21100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUT15_RS21100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUT15_RS21130	COG1970	mechanosensitive ion channel activity
HUT15_RS21140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT15_RS21165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT15_RS21170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT15_RS21180	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT15_RS21185	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUT15_RS21185	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT15_RS21190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT15_RS21210	COG0708	Exodeoxyribonuclease III
HUT15_RS21220	COG2072	flavoprotein involved in K transport
HUT15_RS21225	COG2267	carboxylic ester hydrolase activity
HUT15_RS21240	COG4946	Tricorn protease homolog
HUT15_RS21240	COG0793	Belongs to the peptidase S41A family
HUT15_RS21250	COG2409	Drug exporters of the RND superfamily
HUT15_RS21255	COG0442	prolyl-tRNA aminoacylation
HUT15_RS21275	COG1122	ATPase activity
HUT15_RS21285	COG0310	cobalt ion transport
HUT15_RS21295	COG0768	penicillin binding
HUT15_RS21325	COG0084	hydrolase, TatD family'
HUT15_RS21330	COG1388	LysM domain
HUT15_RS21335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT15_RS21340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUT15_RS21345	COG0488	(ABC) transporter
HUT15_RS21385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUT15_RS21400	COG2197	response regulator
HUT15_RS21410	COG4106	trans-aconitate 2-methyltransferase activity
HUT15_RS21425	COG1309	transcriptional regulator
HUT15_RS21435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUT15_RS21445	COG0193	aminoacyl-tRNA hydrolase activity
HUT15_RS21450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUT15_RS21455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT15_RS21460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT15_RS21475	COG4585	Histidine kinase
HUT15_RS21505	COG1136	(ABC) transporter
HUT15_RS21510	COG0577	efflux transmembrane transporter activity
HUT15_RS21510	COG1136	(ABC) transporter
HUT15_RS21580	COG0148	phosphopyruvate hydratase activity
HUT15_RS21600	COG1252	NADH dehydrogenase
HUT15_RS21605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT15_RS21610	COG1136	(ABC) transporter
HUT15_RS21610	COG0577	efflux transmembrane transporter activity
HUT15_RS21615	COG1136	(ABC) transporter
HUT15_RS21650	COG0183	Belongs to the thiolase family
HUT15_RS21655	COG2755	lipolytic protein G-D-S-L family
HUT15_RS21685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUT15_RS21690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT15_RS21700	COG1228	amidohydrolase
HUT15_RS21710	COG1191	sigma factor activity
HUT15_RS21715	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT15_RS21735	COG3104	oligopeptide transport
HUT15_RS21740	COG0745	RESPONSE REGULATOR receiver
HUT15_RS21745	COG2205	protein histidine kinase activity
HUT15_RS21760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUT15_RS21785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT15_RS21805	COG1316	TRANSCRIPTIONal
HUT15_RS21820	COG1316	TRANSCRIPTIONal
HUT15_RS21825	COG1316	TRANSCRIPTIONal
HUT15_RS21830	COG1316	TRANSCRIPTIONal
HUT15_RS21835	COG1316	TRANSCRIPTIONal
HUT15_RS21840	COG1316	TRANSCRIPTIONal
HUT15_RS21870	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUT15_RS21870	COG0778	Nitroreductase
HUT15_RS21875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT15_RS21910	COG1620	l-lactate permease
HUT15_RS21915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT15_RS21920	COG2835	tetraacyldisaccharide 4'-kinase activity
HUT15_RS21930	COG1482	cell wall glycoprotein biosynthetic process
HUT15_RS21940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT15_RS21980	COG0714	Associated with various cellular activities
HUT15_RS22005	COG0745	RESPONSE REGULATOR receiver
HUT15_RS22010	COG5000	phosphorelay sensor kinase activity
HUT15_RS22010	COG5002	protein histidine kinase activity
HUT15_RS22015	COG0823	Involved in the tonB-independent uptake of proteins
HUT15_RS22025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUT15_RS22030	COG2197	response regulator
HUT15_RS22035	COG3214	Protein conserved in bacteria
HUT15_RS22045	COG0653	protein targeting
HUT15_RS22065	COG2902	Dehydrogenase
HUT15_RS22070	COG1216	Glycosyl transferase, family 2
HUT15_RS22075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT15_RS22080	COG1134	teichoic acid transport
HUT15_RS22110	COG1846	Transcriptional regulator
HUT15_RS22115	COG1764	response to oxidative stress
HUT15_RS22130	COG1216	Glycosyl transferase, family 2
HUT15_RS22135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT15_RS22140	COG1216	Glycosyl transferase, family 2
HUT15_RS22145	COG0395	ABC-type sugar transport system, permease component
HUT15_RS22150	COG1175	transmembrane transport
HUT15_RS22160	COG1674	ftsk spoiiie
HUT15_RS22165	COG0515	serine threonine protein kinase
HUT15_RS22170	COG0515	serine threonine protein kinase
HUT15_RS22175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT15_RS22190	COG2884	Cell division ATP-binding protein ftsE
HUT15_RS22200	COG0793	Belongs to the peptidase S41A family
HUT15_RS22205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT15_RS22220	COG0583	DNA-binding transcription factor activity
HUT15_RS22245	COG2223	nitrite transmembrane transporter activity
HUT15_RS22275	COG3973	AAA domain
HUT15_RS22285	COG0776	regulation of translation
HUT15_RS22290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT15_RS22295	COG1678	Uncharacterized ACR, COG1678
HUT15_RS22310	COG1175	transmembrane transport
HUT15_RS22315	COG0395	ABC-type sugar transport system, permease component
HUT15_RS22320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUT15_RS22335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT15_RS22365	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT15_RS22375	COG1174	glycine betaine transport
HUT15_RS22395	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT15_RS22405	COG0277	FAD linked oxidase domain protein
HUT15_RS22420	COG1714	RDD family
HUT15_RS22440	COG1335	isochorismatase
HUT15_RS22450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUT15_RS22460	COG1113	amino acid transport
HUT15_RS22485	COG1234	tRNA 3'-trailer cleavage
HUT15_RS22490	COG1263	PTS System
HUT15_RS22495	COG1263	PTS System
HUT15_RS22500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUT15_RS22505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUT15_RS22515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUT15_RS22545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT15_RS22560	COG4555	ABC transporter
HUT15_RS22575	COG2733	membrane
HUT15_RS22600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT15_RS22640	COG0702	epimerase
HUT15_RS22650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT15_RS22725	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT15_RS22755	COG4702	Belongs to the UPF0303 family
HUT15_RS22760	COG0673	inositol 2-dehydrogenase activity
HUT15_RS22785	COG0583	DNA-binding transcription factor activity
HUT15_RS22820	COG3397	chitin binding
HUT15_RS22835	COG1126	abc transporter atp-binding protein
HUT15_RS22840	COG0765	amino acid transport
HUT15_RS22845	COG0765	amino acid transport
HUT15_RS22850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT15_RS22865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUT15_RS22915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT15_RS22925	COG4106	trans-aconitate 2-methyltransferase activity
HUT15_RS22980	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUT15_RS22990	COG0745	RESPONSE REGULATOR receiver
HUT15_RS23010	COG0395	ABC-type sugar transport system, permease component
HUT15_RS23035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUT15_RS23040	COG4977	sequence-specific DNA binding
HUT15_RS23050	COG0589	response to stress
HUT15_RS23055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT15_RS23085	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT15_RS23105	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS23120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT15_RS23125	COG1309	transcriptional regulator
HUT15_RS23135	COG1946	Acyl-CoA thioesterase
HUT15_RS23150	COG0028	Belongs to the TPP enzyme family
HUT15_RS23165	COG2356	endonuclease I
HUT15_RS23200	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT15_RS23225	COG1609	Transcriptional regulator
HUT15_RS23230	COG0673	inositol 2-dehydrogenase activity
HUT15_RS23245	COG1869	D-ribose catabolic process
HUT15_RS23250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT15_RS23255	COG1879	ABC-type sugar transport system periplasmic component
HUT15_RS23260	COG1129	ABC transporter
HUT15_RS23275	COG1595	DNA-templated transcription, initiation
HUT15_RS23280	COG0640	Transcriptional regulator
HUT15_RS23315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUT15_RS23340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT15_RS23370	COG1131	(ABC) transporter
HUT15_RS23435	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS23445	COG0728	peptidoglycan biosynthetic process
HUT15_RS23455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT15_RS23490	COG2304	oxidoreductase activity
HUT15_RS23505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT15_RS23510	COG0456	acetyltransferase
HUT15_RS23515	COG2814	Major facilitator Superfamily
HUT15_RS23530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT15_RS23545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT15_RS23550	COG0629	single-stranded DNA binding
HUT15_RS23560	COG2801	Transposase and inactivated derivatives
HUT15_RS23560	COG3415	Transposase
HUT15_RS23565	COG2378	regulation of single-species biofilm formation
HUT15_RS23590	COG0577	efflux transmembrane transporter activity
HUT15_RS23590	COG1136	(ABC) transporter
HUT15_RS23610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT15_RS23640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT15_RS23655	COG1486	melibiose metabolic process
HUT15_RS23660	COG0395	ABC-type sugar transport system, permease component
HUT15_RS23665	COG1175	transmembrane transport
HUT15_RS23670	COG1653	transport
HUT15_RS23695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT15_RS23725	COG1136	(ABC) transporter
HUT15_RS23735	COG4106	trans-aconitate 2-methyltransferase activity
HUT15_RS23765	COG0668	transmembrane transport
HUT15_RS23770	COG1846	Transcriptional regulator
HUT15_RS23775	COG0697	spore germination
HUT15_RS23835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT15_RS23840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUT15_RS23850	COG1268	BioY protein
HUT15_RS23855	COG1113	amino acid transport
HUT15_RS23860	COG0698	ribose 5-phosphate isomerase
HUT15_RS23870	COG4552	Acetyltransferase involved in intracellular survival and related
HUT15_RS23885	COG3594	Acyltransferase
HUT15_RS23905	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUT15_RS23910	COG0740	serine-type endopeptidase activity
HUT15_RS23915	COG0740	serine-type endopeptidase activity
HUT15_RS23920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT15_RS23930	COG0525	valine-tRNA ligase activity
HUT15_RS23935	COG0285	dihydrofolate synthase activity
HUT15_RS23945	COG0105	UTP biosynthetic process
HUT15_RS23950	COG1077	Cell shape determining protein MreB Mrl
HUT15_RS23970	COG0772	Belongs to the SEDS family
HUT15_RS23990	COG1530	ribonuclease E activity
HUT15_RS23995	COG0371	Dehydrogenase
HUT15_RS24000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUT15_RS24005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUT15_RS24010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT15_RS24040	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS24045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT15_RS24050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT15_RS24060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUT15_RS24070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT15_RS24085	COG0501	Belongs to the peptidase M48B family
HUT15_RS24100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUT15_RS24110	COG0799	negative regulation of ribosome biogenesis
HUT15_RS24115	COG0588	phosphoglycerate mutase activity
HUT15_RS24135	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUT15_RS24145	COG0495	leucyl-tRNA aminoacylation
HUT15_RS24155	COG1307	EDD domain protein, DegV family
HUT15_RS24160	COG1555	photosystem II stabilization
HUT15_RS24165	COG1234	tRNA 3'-trailer cleavage
HUT15_RS24185	COG2353	YceI-like domain
HUT15_RS24200	COG0268	Binds directly to 16S ribosomal RNA
HUT15_RS24205	COG0481	GTPase activity
HUT15_RS24235	COG1420	regulation of RNA biosynthetic process
HUT15_RS24240	COG0484	heat shock protein binding
HUT15_RS24265	COG4946	Tricorn protease homolog
HUT15_RS24265	COG0793	Belongs to the peptidase S41A family
HUT15_RS24270	COG0537	adenosine 5'-monophosphoramidase activity
HUT15_RS24275	COG1234	tRNA 3'-trailer cleavage
HUT15_RS24280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT15_RS24290	COG1414	Transcriptional regulator
HUT15_RS24295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT15_RS24300	COG4948	Mandelate Racemase Muconate Lactonizing
HUT15_RS24310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT15_RS24315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUT15_RS24335	COG2315	Protein conserved in bacteria
HUT15_RS24345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT15_RS24370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT15_RS24415	COG2409	Drug exporters of the RND superfamily
HUT15_RS24420	COG4585	Histidine kinase
HUT15_RS24425	COG2197	response regulator
HUT15_RS24465	COG1381	Involved in DNA repair and RecF pathway recombination
HUT15_RS24470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT15_RS24485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT15_RS24490	COG1121	(ABC) transporter
HUT15_RS24495	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUT15_RS24495	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT15_RS24500	COG0423	glycine-tRNA ligase activity
HUT15_RS24510	COG0477	Major facilitator Superfamily
HUT15_RS24550	COG0574	Belongs to the PEP-utilizing enzyme family
HUT15_RS24550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT15_RS24555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT15_RS24575	COG2146	nitrite reductase [NAD(P)H] activity
HUT15_RS24575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT15_RS24625	COG0243	molybdopterin cofactor binding
HUT15_RS24630	COG2949	membrane
HUT15_RS24640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT15_RS24650	COG0358	DNA primase activity
HUT15_RS24655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT15_RS24670	COG1070	Carbohydrate kinase
HUT15_RS24710	COG1404	Belongs to the peptidase S8 family
HUT15_RS24715	COG0825	malonyl-CoA metabolic process
HUT15_RS24715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUT15_RS24720	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS24730	COG2186	Transcriptional regulator
HUT15_RS24740	COG1414	Transcriptional regulator
HUT15_RS24745	COG3386	PFAM SMP-30 Gluconolaconase
HUT15_RS24775	COG1175	transmembrane transport
HUT15_RS24780	COG0395	ABC-type sugar transport system, permease component
HUT15_RS24800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUT15_RS24805	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT15_RS24830	COG1127	ABC transporter
HUT15_RS24840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT15_RS24865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUT15_RS24900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT15_RS24910	COG4214	carbohydrate transport
HUT15_RS24915	COG1129	ABC transporter
HUT15_RS24950	COG2130	NADP-dependent
HUT15_RS24955	COG1764	response to oxidative stress
HUT15_RS24985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUT15_RS24990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT15_RS24995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS25000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT15_RS25025	COG3693	PFAM glycoside hydrolase, family 10
HUT15_RS25045	COG0789	Transcriptional regulator
HUT15_RS25050	COG0667	Aldo Keto reductase
HUT15_RS25065	COG1309	transcriptional regulator
HUT15_RS25070	COG0477	Major facilitator Superfamily
HUT15_RS25075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT15_RS25120	COG1358	cellular component organization or biogenesis
HUT15_RS25130	COG0586	Pfam SNARE associated Golgi protein
HUT15_RS25135	COG4585	Histidine kinase
HUT15_RS25140	COG2201	protein-glutamate methylesterase activity
HUT15_RS25245	COG4122	O-methyltransferase activity
HUT15_RS25275	COG3409	Peptidoglycan-binding domain 1 protein
HUT15_RS25325	COG3845	ABC transporter
HUT15_RS25340	COG1657	PFAM Prenyltransferase squalene oxidase
HUT15_RS25350	COG1309	transcriptional regulator
HUT15_RS25355	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS25380	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUT15_RS25390	COG0477	Major facilitator Superfamily
HUT15_RS25400	COG2197	response regulator
HUT15_RS25405	COG4585	Histidine kinase
HUT15_RS25415	COG1131	(ABC) transporter
HUT15_RS25420	COG2030	dehydratase
HUT15_RS25435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUT15_RS25450	COG0800	Aldolase
HUT15_RS25455	COG3022	response to hydroperoxide
HUT15_RS25495	COG1280	lysine exporter protein (LysE YggA)
HUT15_RS25525	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUT15_RS25535	COG2267	carboxylic ester hydrolase activity
HUT15_RS25550	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS25600	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS25605	COG3540	Alkaline phosphatase
HUT15_RS25615	COG2814	Major facilitator Superfamily
HUT15_RS25620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT15_RS25630	COG2197	response regulator
HUT15_RS25650	COG0672	)-iron permease
HUT15_RS25655	COG2837	iron assimilation
HUT15_RS25665	COG1120	ATPase activity
HUT15_RS25670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT15_RS25695	COG0384	phenazine biosynthesis protein PhzF
HUT15_RS25735	COG1994	Peptidase M50
HUT15_RS25755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT15_RS25765	COG2814	Major facilitator Superfamily
HUT15_RS25810	COG0174	glutamine synthetase
HUT15_RS25830	COG2161	toxin-antitoxin pair type II binding
HUT15_RS25835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUT15_RS25845	COG1609	Transcriptional regulator
HUT15_RS25855	COG1175	transmembrane transport
HUT15_RS25860	COG3833	ABC-type maltose transport systems, permease component
HUT15_RS25865	COG0366	Alpha amylase catalytic
HUT15_RS25885	COG1309	transcriptional regulator
HUT15_RS25915	COG2197	response regulator
HUT15_RS25930	COG0745	RESPONSE REGULATOR receiver
HUT15_RS25985	COG0501	Belongs to the peptidase M48B family
HUT15_RS25990	COG1733	regulation of RNA biosynthetic process
HUT15_RS26005	COG0174	glutamine synthetase
HUT15_RS26025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUT15_RS26030	COG0321	lipoyl(octanoyl) transferase activity
HUT15_RS26075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT15_RS26085	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT15_RS26090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT15_RS26095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT15_RS26105	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUT15_RS26115	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT15_RS26135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT15_RS26140	COG2226	methyltransferase
HUT15_RS26160	COG4585	Histidine kinase
HUT15_RS26165	COG2197	response regulator
HUT15_RS26170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUT15_RS26180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUT15_RS26200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT15_RS26210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUT15_RS26215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT15_RS26225	COG1376	ErfK ybiS ycfS ynhG family protein
HUT15_RS26235	COG1845	cytochrome c oxidase, subunit III
HUT15_RS26240	COG2010	Cytochrome c
HUT15_RS26245	COG0723	plastoquinol--plastocyanin reductase activity
HUT15_RS26250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT15_RS26255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT15_RS26260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT15_RS26265	COG1929	Belongs to the glycerate kinase type-1 family
HUT15_RS26275	COG0745	RESPONSE REGULATOR receiver
HUT15_RS26280	COG2205	protein histidine kinase activity
HUT15_RS26330	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS26350	COG0003	Pfam Anion-transporting ATPase
HUT15_RS26360	COG1940	carbohydrate kinase activity
HUT15_RS26385	COG4585	Histidine kinase
HUT15_RS26390	COG2197	response regulator
HUT15_RS26395	COG0205	6-phosphofructokinase activity
HUT15_RS26400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUT15_RS26420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT15_RS26430	COG2193	ferroxidase activity
HUT15_RS26435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT15_RS26440	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT15_RS26445	COG2815	serine threonine protein kinase
HUT15_RS26445	COG0515	serine threonine protein kinase
HUT15_RS26450	COG2022	thiamine diphosphate biosynthetic process
HUT15_RS26460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT15_RS26460	COG2022	thiamine diphosphate biosynthetic process
HUT15_RS26465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT15_RS26475	COG0352	thiamine-phosphate diphosphorylase activity
HUT15_RS26495	COG1309	transcriptional regulator
HUT15_RS26525	COG0714	Associated with various cellular activities
HUT15_RS26535	COG0275	rRNA processing
HUT15_RS26545	COG0768	penicillin binding
HUT15_RS26550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT15_RS26555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUT15_RS26560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT15_RS26565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT15_RS26575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUT15_RS26580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUT15_RS26585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUT15_RS26600	COG1799	cell septum assembly
HUT15_RS26610	COG3599	regulation of cell shape
HUT15_RS26615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUT15_RS26625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUT15_RS26640	COG0025	NhaP-type Na H and K H
HUT15_RS26675	COG0587	DNA-directed DNA polymerase activity
HUT15_RS26685	COG1432	Conserved Protein
HUT15_RS26705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUT15_RS26725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUT15_RS26730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT15_RS26735	COG0131	Imidazoleglycerol-phosphate dehydratase
HUT15_RS26745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUT15_RS26750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUT15_RS26755	COG0251	oxidation-reduction process
HUT15_RS26760	COG0107	imidazoleglycerol-phosphate synthase activity
HUT15_RS26785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT15_RS26810	COG0134	indole-3-glycerol-phosphate synthase activity
HUT15_RS26815	COG0133	tryptophan synthase activity
HUT15_RS26820	COG0159	tryptophan synthase activity
HUT15_RS26830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUT15_RS26835	COG2301	Belongs to the HpcH HpaI aldolase family
HUT15_RS26840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT15_RS26875	COG0069	glutamate synthase activity
HUT15_RS26875	COG0070	glutamate synthase
HUT15_RS26875	COG0067	glutamate synthase
HUT15_RS26895	COG2304	oxidoreductase activity
HUT15_RS26900	COG2968	Membrane
HUT15_RS26910	COG0287	Prephenate dehydrogenase
HUT15_RS26910	COG1605	Chorismate mutase
HUT15_RS26930	COG0737	Belongs to the 5'-nucleotidase family
HUT15_RS26985	COG2050	protein possibly involved in aromatic compounds catabolism
HUT15_RS27010	COG1643	Atp-dependent helicase
HUT15_RS27015	COG2226	methyltransferase
HUT15_RS27020	COG0539	negative regulation of cytoplasmic translation
HUT15_RS27030	COG0237	dephospho-CoA kinase activity
HUT15_RS27045	COG2226	methyltransferase
HUT15_RS27065	COG2267	carboxylic ester hydrolase activity
HUT15_RS27140	COG2226	methyltransferase
HUT15_RS27150	COG2313	pseudouridylate synthase activity
HUT15_RS27165	COG0584	glycerophosphoryl diester phosphodiesterase
HUT15_RS27175	COG0556	nucleotide-excision repair
HUT15_RS27195	COG0387	Pfam Sodium calcium exchanger
HUT15_RS27200	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT15_RS27205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUT15_RS27220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT15_RS27245	COG0322	excinuclease ABC activity
HUT15_RS27250	COG1660	Displays ATPase and GTPase activities
HUT15_RS27255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT15_RS27260	COG1481	regulation of sporulation
HUT15_RS27270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT15_RS27275	COG0126	phosphoglycerate kinase activity
HUT15_RS27280	COG0149	triose-phosphate isomerase activity
HUT15_RS27285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT15_RS27295	COG0166	Belongs to the GPI family
HUT15_RS27305	COG1136	(ABC) transporter
HUT15_RS27310	COG1695	Transcriptional regulator
HUT15_RS27315	COG1653	transport
HUT15_RS27320	COG0366	Alpha amylase catalytic
HUT15_RS27330	COG1175	transmembrane transport
HUT15_RS27335	COG0395	ABC-type sugar transport system, permease component
HUT15_RS27340	COG0363	glucosamine-6-phosphate deaminase activity
HUT15_RS27355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT15_RS27365	COG0109	protoheme IX farnesyltransferase activity
HUT15_RS27395	COG1131	(ABC) transporter
HUT15_RS27400	COG2746	aminoglycoside 3-N-acetyltransferase activity
HUT15_RS27415	COG0719	Fe-S assembly protein
HUT15_RS27425	COG0396	ATPase activity
HUT15_RS27430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT15_RS27435	COG0822	iron-sulfur transferase activity
HUT15_RS27440	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT15_RS27445	COG2076	Multidrug Resistance protein
HUT15_RS27450	COG3226	Transcriptional regulator
HUT15_RS27455	COG2171	N-acyltransferase activity
HUT15_RS27470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT15_RS27510	COG1802	Transcriptional regulator
HUT15_RS27520	COG1309	transcriptional regulator
HUT15_RS27535	COG1063	alcohol dehydrogenase
HUT15_RS27555	COG1349	DNA-binding transcription factor activity
HUT15_RS27560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT15_RS27565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT15_RS27590	COG1802	Transcriptional regulator
HUT15_RS27605	COG1175	transmembrane transport
HUT15_RS27610	COG0395	ABC-type sugar transport system, permease component
HUT15_RS27625	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT15_RS27635	COG2755	lipolytic protein G-D-S-L family
HUT15_RS27640	COG3866	Pectate lyase
HUT15_RS27645	COG4677	pectinesterase activity
HUT15_RS27655	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT15_RS27665	COG1595	DNA-templated transcription, initiation
HUT15_RS27670	COG0768	penicillin binding
HUT15_RS27675	COG2197	response regulator
HUT15_RS27680	COG4585	Histidine kinase
HUT15_RS27695	COG1414	Transcriptional regulator
HUT15_RS27720	COG5285	phytanoyl-CoA dioxygenase
HUT15_RS27725	COG1917	Cupin 2, conserved barrel domain protein
HUT15_RS27730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT15_RS27735	COG0456	acetyltransferase
HUT15_RS27740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUT15_RS27765	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HUT15_RS27795	COG1797	cobyrinic acid a,c-diamide synthase activity
HUT15_RS27815	COG1492	cobalamin metabolic process
HUT15_RS27820	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUT15_RS27835	COG0235	Class ii aldolase
HUT15_RS27855	COG0488	(ABC) transporter
HUT15_RS27865	COG1024	Enoyl-CoA hydratase
HUT15_RS27900	COG3387	PFAM Glycoside hydrolase 15-related
HUT15_RS27925	COG1404	Belongs to the peptidase S8 family
HUT15_RS27935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT15_RS27940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT15_RS27960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUT15_RS27975	COG1205	dead DEAH box helicase
HUT15_RS27975	COG1111	helicase
HUT15_RS27985	COG1002	Type II restriction enzyme, methylase subunits
HUT15_RS28010	COG1401	restriction endodeoxyribonuclease activity
HUT15_RS28025	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HUT15_RS28030	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS28040	COG2186	Transcriptional regulator
HUT15_RS28060	COG3830	Belongs to the UPF0237 family
HUT15_RS28060	COG0560	Phosphoserine phosphatase
HUT15_RS28070	COG1716	ATPase activity
HUT15_RS28070	COG1131	(ABC) transporter
HUT15_RS28070	COG0842	Transport permease protein
HUT15_RS28080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUT15_RS28085	COG4221	oxidoreductase activity
HUT15_RS28090	COG4585	Histidine kinase
HUT15_RS28095	COG2197	response regulator
HUT15_RS28110	COG1119	ATPase activity
HUT15_RS28130	COG1881	PFAM PEBP family protein
HUT15_RS28140	COG2094	Belongs to the DNA glycosylase MPG family
HUT15_RS28170	COG0647	UMP catabolic process
HUT15_RS28175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT15_RS28180	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT15_RS28185	COG1120	ATPase activity
HUT15_RS28205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT15_RS28210	COG0497	DNA recombination
HUT15_RS28215	COG0297	glycogen (starch) synthase activity
HUT15_RS28230	COG3387	PFAM Glycoside hydrolase 15-related
HUT15_RS28235	COG0504	CTP synthase activity
HUT15_RS28240	COG0494	nUDIX hydrolase
HUT15_RS28250	COG0686	Belongs to the AlaDH PNT family
HUT15_RS28265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUT15_RS28270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUT15_RS28275	COG1187	pseudouridine synthase activity
HUT15_RS28290	COG3541	Predicted nucleotidyltransferase
HUT15_RS28315	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUT15_RS28325	COG1160	GTP binding
HUT15_RS28350	COG0671	phosphoesterase, PA-phosphatase related
HUT15_RS28360	COG0477	Major facilitator Superfamily
HUT15_RS28370	COG1799	cell septum assembly
HUT15_RS28390	COG4585	Histidine kinase
HUT15_RS28410	COG0587	DNA-directed DNA polymerase activity
HUT15_RS28420	COG0662	Cupin 2, conserved barrel domain protein
HUT15_RS28420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT15_RS28445	COG2226	methyltransferase
HUT15_RS28460	COG1725	Transcriptional regulator
HUT15_RS28475	COG2755	lipolytic protein G-D-S-L family
HUT15_RS28480	COG1595	DNA-templated transcription, initiation
HUT15_RS28515	COG2188	Transcriptional regulator
HUT15_RS28520	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUT15_RS28530	COG1309	transcriptional regulator
HUT15_RS28535	COG0243	molybdopterin cofactor binding
HUT15_RS28540	COG2851	Citrate transporter
HUT15_RS28555	COG3842	ATPase activity
HUT15_RS28575	COG0640	Transcriptional regulator
HUT15_RS28585	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS28605	COG0789	Transcriptional regulator
HUT15_RS28625	COG3876	Protein conserved in bacteria
HUT15_RS28660	COG2149	membrane
HUT15_RS28665	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT15_RS28685	COG1063	alcohol dehydrogenase
HUT15_RS28690	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS28700	COG3265	gluconokinase activity
HUT15_RS28705	COG2186	Transcriptional regulator
HUT15_RS28710	COG3012	SEC-C Motif Domain Protein
HUT15_RS28720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT15_RS28750	COG0667	Aldo Keto reductase
HUT15_RS28755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT15_RS28765	COG0598	Magnesium transport protein CorA
HUT15_RS28770	COG0588	phosphoglycerate mutase activity
HUT15_RS28785	COG0215	cysteine-tRNA ligase activity
HUT15_RS28795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT15_RS28800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT15_RS28805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT15_RS28810	COG1414	Transcriptional regulator
HUT15_RS28815	COG0646	methionine synthase
HUT15_RS28815	COG1410	methionine synthase
HUT15_RS28820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT15_RS28825	COG4166	transmembrane transport
HUT15_RS28830	COG2197	response regulator
HUT15_RS28840	COG1994	Peptidase M50
HUT15_RS28840	COG0517	IMP dehydrogenase activity
HUT15_RS28860	COG1222	aaa ATPase
HUT15_RS28865	COG4122	O-methyltransferase activity
HUT15_RS28880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT15_RS28885	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT15_RS28890	COG1609	Transcriptional regulator
HUT15_RS28900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT15_RS28905	COG0545	Peptidyl-prolyl cis-trans isomerase
HUT15_RS28940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT15_RS28945	COG0805	protein transport
HUT15_RS28980	COG0564	pseudouridine synthase activity
HUT15_RS28995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT15_RS29000	COG4175	Glycine betaine
HUT15_RS29000	COG0517	IMP dehydrogenase activity
HUT15_RS29005	COG4176	ABC-type proline glycine betaine transport system permease component
HUT15_RS29030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUT15_RS29040	COG0174	glutamine synthetase
HUT15_RS29045	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS29050	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS29090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUT15_RS29095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUT15_RS29100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUT15_RS29105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT15_RS29110	COG5002	protein histidine kinase activity
HUT15_RS29115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUT15_RS29120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT15_RS29120	COG0072	phenylalanine-tRNA ligase activity
HUT15_RS29140	COG1649	PFAM Uncharacterised BCR, COG1649
HUT15_RS29180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUT15_RS29185	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUT15_RS29190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT15_RS29195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT15_RS29200	COG1438	arginine binding
HUT15_RS29235	COG0165	Argininosuccinate lyase
HUT15_RS29250	COG0477	Major facilitator Superfamily
HUT15_RS29255	COG0204	Acyl-transferase
HUT15_RS29255	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS29260	COG0584	glycerophosphoryl diester phosphodiesterase
HUT15_RS29290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT15_RS29295	COG2011	ABC-type metal ion transport system permease component
HUT15_RS29300	COG1464	Belongs to the NlpA lipoprotein family
HUT15_RS29315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT15_RS29320	COG1648	precorrin-2 dehydrogenase activity
HUT15_RS29320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT15_RS29375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUT15_RS29430	COG1175	transmembrane transport
HUT15_RS29435	COG0395	ABC-type sugar transport system, permease component
HUT15_RS29460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUT15_RS29475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT15_RS29495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUT15_RS29500	COG1560	Kdo2-lipid A biosynthetic process
HUT15_RS29505	COG0438	transferase activity, transferring glycosyl groups
HUT15_RS29515	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUT15_RS29520	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUT15_RS29525	COG0217	transcriptional regulatory protein
HUT15_RS29530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUT15_RS29535	COG0632	four-way junction helicase activity
HUT15_RS29540	COG2255	four-way junction helicase activity
HUT15_RS29550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT15_RS29555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT15_RS29560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT15_RS29565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT15_RS29570	COG1196	nuclear chromosome segregation
HUT15_RS29575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUT15_RS29585	COG0124	histidyl-tRNA synthetase
HUT15_RS29600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT15_RS29620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT15_RS29625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUT15_RS29635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUT15_RS29645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT15_RS29650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT15_RS29655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT15_RS29665	COG0006	proline dipeptidase activity
HUT15_RS29670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUT15_RS29675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUT15_RS29685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUT15_RS29690	COG0540	Belongs to the ATCase OTCase family
HUT15_RS29695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT15_RS29705	COG0505	Belongs to the CarA family
HUT15_RS29710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT15_RS29715	COG0167	dihydroorotate dehydrogenase activity
HUT15_RS29720	COG0284	orotidine-5'-phosphate decarboxylase activity
HUT15_RS29730	COG0194	GDP metabolic process
HUT15_RS29735	COG1758	RNA polymerase activity
HUT15_RS29745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT15_RS29760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUT15_RS29785	COG0515	serine threonine protein kinase
HUT15_RS29800	COG1653	transport
HUT15_RS29805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUT15_RS29810	COG2390	Transcriptional regulator
HUT15_RS29830	COG0531	amino acid
HUT15_RS29850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT15_RS29875	COG2233	PERMEase
HUT15_RS29885	COG2223	nitrite transmembrane transporter activity
HUT15_RS29890	COG1846	Transcriptional regulator
HUT15_RS29915	COG3201	nicotinamide mononucleotide transporter
HUT15_RS29920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT15_RS29920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT15_RS29925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUT15_RS29930	COG0140	phosphoribosyl-ATP diphosphatase activity
HUT15_RS29935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUT15_RS29985	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS30010	COG0463	Glycosyl transferase, family 2
HUT15_RS30025	COG2270	Major facilitator Superfamily
HUT15_RS30035	COG2364	Membrane
HUT15_RS30065	COG4336	lyase activity
HUT15_RS30070	COG2814	Major facilitator Superfamily
HUT15_RS30100	COG0326	Molecular chaperone. Has ATPase activity
HUT15_RS30120	COG2018	Roadblock/LC7 domain
HUT15_RS30135	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUT15_RS30150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT15_RS30160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT15_RS30190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT15_RS30210	COG1716	ATPase activity
HUT15_RS30230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT15_RS30240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT15_RS30240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT15_RS30260	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUT15_RS30270	COG1609	Transcriptional regulator
HUT15_RS30295	COG0384	phenazine biosynthesis protein PhzF
HUT15_RS30300	COG2197	response regulator
HUT15_RS30305	COG4585	Histidine kinase
HUT15_RS30315	COG0577	efflux transmembrane transporter activity
HUT15_RS30315	COG1136	(ABC) transporter
HUT15_RS30355	COG0697	spore germination
HUT15_RS30370	COG0723	plastoquinol--plastocyanin reductase activity
HUT15_RS30410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT15_RS30425	COG2318	DinB family
HUT15_RS30445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUT15_RS30450	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS30485	COG1968	undecaprenyl-diphosphatase activity
HUT15_RS30500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT15_RS30535	COG0110	maltose O-acetyltransferase activity
HUT15_RS30555	COG0640	Transcriptional regulator
HUT15_RS30560	COG1832	CoA-binding protein
HUT15_RS30570	COG1739	Uncharacterized protein family UPF0029
HUT15_RS30605	COG0420	3'-5' exonuclease activity
HUT15_RS30610	COG0419	ATPase involved in DNA repair
HUT15_RS30615	COG1522	sequence-specific DNA binding
HUT15_RS30630	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS30645	COG0626	cystathionine gamma-synthase activity
HUT15_RS30670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT15_RS30710	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HUT15_RS30710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT15_RS30720	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT15_RS30725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT15_RS30750	COG3320	Male sterility
HUT15_RS30750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS30755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS30760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT15_RS30765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT15_RS30770	COG0022	dehydrogenase e1 component
HUT15_RS30775	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT15_RS30780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT15_RS30785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT15_RS30795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT15_RS30795	COG0596	Alpha beta hydrolase
HUT15_RS30800	COG1595	DNA-templated transcription, initiation
HUT15_RS30805	COG2188	Transcriptional regulator
HUT15_RS30810	COG1940	carbohydrate kinase activity
HUT15_RS30815	COG2197	response regulator
HUT15_RS30820	COG4585	Histidine kinase
HUT15_RS30860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT15_RS30880	COG0456	acetyltransferase
HUT15_RS30900	COG2226	methyltransferase
HUT15_RS30905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUT15_RS30910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT15_RS30915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUT15_RS30920	COG0156	8-amino-7-oxononanoate synthase activity
HUT15_RS30945	COG0831	urea catabolic process
HUT15_RS30950	COG0832	Belongs to the urease beta subunit family
HUT15_RS30955	COG0804	urea catabolic process
HUT15_RS30965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUT15_RS30970	COG0829	nickel cation binding
HUT15_RS30985	COG0204	Acyl-transferase
HUT15_RS31010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT15_RS31015	COG1834	amidinotransferase
HUT15_RS31020	COG1522	sequence-specific DNA binding
HUT15_RS31035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT15_RS31040	COG3275	phosphorelay sensor kinase activity
HUT15_RS31055	COG0205	6-phosphofructokinase activity
HUT15_RS31060	COG3442	glutamine amidotransferase
HUT15_RS31065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT15_RS31070	COG0242	peptide deformylase activity
HUT15_RS31080	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS31090	COG2124	cytochrome p450
HUT15_RS31095	COG3424	synthase
HUT15_RS31105	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS31115	COG1793	dna ligase
HUT15_RS31125	COG3800	Transcriptional regulator
HUT15_RS31125	COG1396	sequence-specific DNA binding
HUT15_RS31135	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS31140	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS31165	COG0477	Major facilitator Superfamily
HUT15_RS31250	COG0270	DNA (cytosine-5-)-methyltransferase activity
HUT15_RS31260	COG0210	DNA helicase
HUT15_RS31270	COG1012	belongs to the aldehyde dehydrogenase family
HUT15_RS31285	COG1846	Transcriptional regulator
HUT15_RS31285	COG1940	carbohydrate kinase activity
HUT15_RS31290	COG1070	Carbohydrate kinase
HUT15_RS31295	COG2115	Belongs to the xylose isomerase family
HUT15_RS31305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT15_RS31365	COG2018	Roadblock/LC7 domain
HUT15_RS31375	COG1946	Acyl-CoA thioesterase
HUT15_RS31390	COG0254	rRNA binding
HUT15_RS31400	COG1132	(ABC) transporter
HUT15_RS31420	COG1132	(ABC) transporter
HUT15_RS31430	COG2072	flavoprotein involved in K transport
HUT15_RS31435	COG0432	Pfam Uncharacterised protein family UPF0047
HUT15_RS31465	COG3290	protein histidine kinase activity
HUT15_RS31470	COG4565	transcriptional regulatory protein
HUT15_RS31480	COG2080	2 iron, 2 sulfur cluster binding
HUT15_RS31485	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT15_RS31490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT15_RS31500	COG3387	PFAM Glycoside hydrolase 15-related
HUT15_RS31515	COG4221	oxidoreductase activity
HUT15_RS31550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT15_RS31565	COG2706	6-phosphogluconolactonase activity
HUT15_RS31575	COG2971	BadF BadG BcrA BcrD
HUT15_RS31580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT15_RS31590	COG1960	acyl-CoA dehydrogenase activity
HUT15_RS31605	COG1902	pentaerythritol trinitrate reductase activity
HUT15_RS31610	COG0640	Transcriptional regulator
HUT15_RS31630	COG1309	transcriptional regulator
HUT15_RS31640	COG0671	phosphoesterase, PA-phosphatase related
HUT15_RS31680	COG0584	glycerophosphoryl diester phosphodiesterase
HUT15_RS31705	COG0204	Acyl-transferase
HUT15_RS31725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUT15_RS31755	COG1660	Displays ATPase and GTPase activities
HUT15_RS31760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT15_RS31765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT15_RS31770	COG0445	tRNA wobble uridine modification
HUT15_RS31775	COG4585	Histidine kinase
HUT15_RS31780	COG2197	response regulator
HUT15_RS31800	COG0738	Major facilitator superfamily
HUT15_RS31805	COG1609	Transcriptional regulator
HUT15_RS31815	COG1175	transmembrane transport
HUT15_RS31820	COG0395	ABC-type sugar transport system, permease component
HUT15_RS31825	COG3250	beta-galactosidase activity
HUT15_RS31835	COG2723	6-phospho-beta-galactosidase activity
HUT15_RS31840	COG0395	ABC-type sugar transport system, permease component
HUT15_RS31845	COG1175	transmembrane transport
HUT15_RS31855	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT15_RS31870	COG0783	Belongs to the Dps family
HUT15_RS31875	COG0673	inositol 2-dehydrogenase activity
HUT15_RS31895	COG2608	mercury ion transmembrane transporter activity
HUT15_RS31910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT15_RS31915	COG0191	fructose-bisphosphate aldolase activity
HUT15_RS31920	COG2813	Specifically methylates the guanine in position
HUT15_RS31930	COG1940	carbohydrate kinase activity
HUT15_RS31970	COG1136	(ABC) transporter
HUT15_RS31975	COG0577	efflux transmembrane transporter activity
HUT15_RS31990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT15_RS32000	COG1349	DNA-binding transcription factor activity
HUT15_RS32040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUT15_RS32060	COG3345	alpha-galactosidase
HUT15_RS32075	COG1609	Transcriptional regulator
HUT15_RS32085	COG1175	transmembrane transport
HUT15_RS32095	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT15_RS32120	COG0137	argininosuccinate synthase activity
HUT15_RS32140	COG0444	Belongs to the ABC transporter superfamily
HUT15_RS32145	COG0601	transmembrane transport
HUT15_RS32150	COG0747	negative chemotaxis
HUT15_RS32160	COG3458	cephalosporin-C deacetylase activity
HUT15_RS32170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT15_RS32175	COG1940	carbohydrate kinase activity
HUT15_RS32180	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUT15_RS32200	COG0640	Transcriptional regulator
HUT15_RS32205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT15_RS32210	COG1993	acr, cog1993
HUT15_RS32215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT15_RS32220	COG1968	undecaprenyl-diphosphatase activity
HUT15_RS32230	COG2066	Belongs to the glutaminase family
HUT15_RS32240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUT15_RS32255	COG2226	methyltransferase
HUT15_RS32260	COG2188	Transcriptional regulator
HUT15_RS32265	COG3458	cephalosporin-C deacetylase activity
HUT15_RS32280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT15_RS32290	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT15_RS32310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT15_RS32310	COG1902	pentaerythritol trinitrate reductase activity
HUT15_RS32340	COG1461	Dihydroxyacetone kinase
HUT15_RS32345	COG2376	Dihydroxyacetone kinase
HUT15_RS32355	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HUT15_RS32375	COG2205	protein histidine kinase activity
HUT15_RS32380	COG0745	RESPONSE REGULATOR receiver
HUT15_RS32395	COG1073	alpha beta
HUT15_RS32420	COG0662	Cupin 2, conserved barrel domain protein
HUT15_RS32425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT15_RS32435	COG0561	phosphatase activity
HUT15_RS32440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT15_RS32445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUT15_RS32470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT15_RS32475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT15_RS32490	COG1609	Transcriptional regulator
HUT15_RS32500	COG1175	transmembrane transport
HUT15_RS32505	COG3833	ABC-type maltose transport systems, permease component
HUT15_RS32510	COG0366	Alpha amylase catalytic
HUT15_RS32560	COG1131	(ABC) transporter
HUT15_RS32565	COG1725	Transcriptional regulator
HUT15_RS32575	COG2197	response regulator
HUT15_RS32580	COG4585	Histidine kinase
HUT15_RS32585	COG2409	Drug exporters of the RND superfamily
HUT15_RS32635	COG0745	RESPONSE REGULATOR receiver
HUT15_RS32640	COG2205	protein histidine kinase activity
HUT15_RS32650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT15_RS32685	COG0515	serine threonine protein kinase
HUT15_RS32700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT15_RS32705	COG0318	PFAM AMP-dependent synthetase and ligase
HUT15_RS32750	COG0673	inositol 2-dehydrogenase activity
HUT15_RS32795	COG0667	Aldo Keto reductase
HUT15_RS32800	COG0346	lactoylglutathione lyase activity
HUT15_RS32805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT15_RS32815	COG0583	DNA-binding transcription factor activity
HUT15_RS32820	COG0667	Aldo Keto reductase
HUT15_RS32855	COG1191	sigma factor activity
HUT15_RS32860	COG1396	sequence-specific DNA binding
HUT15_RS32865	COG0740	serine-type endopeptidase activity
HUT15_RS32870	COG0740	serine-type endopeptidase activity
HUT15_RS32885	COG0328	RNA-DNA hybrid ribonuclease activity
HUT15_RS32895	COG0667	Aldo Keto reductase
HUT15_RS32915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT15_RS32920	COG0515	serine threonine protein kinase
HUT15_RS32925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT15_RS32935	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT15_RS32935	COG1672	PFAM Archaeal ATPase
HUT15_RS32965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT15_RS33005	COG0477	Major facilitator Superfamily
HUT15_RS33015	COG1982	Orn Lys Arg decarboxylase major
HUT15_RS33055	COG1252	NADH dehydrogenase
HUT15_RS33070	COG2172	sigma factor antagonist activity
HUT15_RS33075	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT15_RS33080	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT15_RS33095	COG5002	protein histidine kinase activity
HUT15_RS33095	COG2205	protein histidine kinase activity
HUT15_RS33095	COG0784	Response regulator, receiver
HUT15_RS33125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT15_RS33130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUT15_RS33145	COG0366	Alpha amylase catalytic
HUT15_RS33175	COG1191	sigma factor activity
HUT15_RS33185	COG0181	hydroxymethylbilane synthase activity
HUT15_RS33195	COG1793	dna ligase
HUT15_RS33195	COG3285	dna ligase
HUT15_RS33220	COG2208	phosphoserine phosphatase activity
HUT15_RS33230	COG0656	L-ascorbic acid biosynthetic process
HUT15_RS33245	COG0009	L-threonylcarbamoyladenylate synthase
HUT15_RS33285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUT15_RS33300	COG1088	dTDP-glucose 4,6-dehydratase activity
HUT15_RS33315	COG0456	acetyltransferase
HUT15_RS33350	COG2124	cytochrome p450
HUT15_RS33355	COG0475	glutathione-regulated potassium exporter activity
HUT15_RS33380	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS33430	COG1120	ATPase activity
HUT15_RS33455	COG0110	maltose O-acetyltransferase activity
HUT15_RS33475	COG0395	ABC-type sugar transport system, permease component
HUT15_RS33480	COG4209	transmembrane transport
HUT15_RS33490	COG0028	Belongs to the TPP enzyme family
HUT15_RS33495	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS33520	COG2814	Major facilitator Superfamily
HUT15_RS33530	COG1959	2 iron, 2 sulfur cluster binding
HUT15_RS33555	COG5640	endopeptidase activity
HUT15_RS33560	COG0583	DNA-binding transcription factor activity
HUT15_RS33570	COG2814	Major facilitator Superfamily
HUT15_RS33585	COG0583	DNA-binding transcription factor activity
HUT15_RS33590	COG3340	Belongs to the peptidase S51 family
HUT15_RS33605	COG2124	cytochrome p450
HUT15_RS33660	COG1335	isochorismatase
HUT15_RS33675	COG1119	ATPase activity
HUT15_RS33735	COG2050	protein possibly involved in aromatic compounds catabolism
HUT15_RS33740	COG3396	Phenylacetate-CoA oxygenase
HUT15_RS33745	COG3460	Phenylacetate-CoA oxygenase
HUT15_RS33750	COG3396	Phenylacetate-CoA oxygenase
HUT15_RS33755	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT15_RS33760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT15_RS33810	COG1953	Uracil, thiamine, allantoin
HUT15_RS33825	COG1175	transmembrane transport
HUT15_RS33830	COG0395	ABC-type sugar transport system, permease component
HUT15_RS33840	COG2175	clavaminate synthase activity
HUT15_RS33865	COG4977	sequence-specific DNA binding
HUT15_RS33870	COG2755	lipolytic protein G-D-S-L family
HUT15_RS33880	COG0326	Molecular chaperone. Has ATPase activity
HUT15_RS33885	COG2391	methyltransferase activity
HUT15_RS33890	COG3226	Transcriptional regulator
HUT15_RS33905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT15_RS33935	COG2409	Drug exporters of the RND superfamily
HUT15_RS33940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT15_RS33950	COG0516	GMP reductase activity
HUT15_RS33950	COG0517	IMP dehydrogenase activity
HUT15_RS33985	COG3119	arylsulfatase activity
HUT15_RS33990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT15_RS33995	COG0584	glycerophosphoryl diester phosphodiesterase
HUT15_RS34030	COG0395	ABC-type sugar transport system, permease component
HUT15_RS34045	COG1051	belongs to the nudix hydrolase family
HUT15_RS34050	COG0584	glycerophosphoryl diester phosphodiesterase
HUT15_RS34060	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT15_RS34105	COG5297	Belongs to the glycosyl hydrolase family 6
HUT15_RS34105	COG3250	beta-galactosidase activity
HUT15_RS34145	COG0667	Aldo Keto reductase
HUT15_RS34150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUT15_RS34155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT15_RS34165	COG1737	Transcriptional regulator
HUT15_RS34170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT15_RS34180	COG0154	amidase activity
HUT15_RS34185	COG1309	transcriptional regulator
HUT15_RS34230	COG2353	YceI-like domain
HUT15_RS34255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HUT15_RS34260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUT15_RS34275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT15_RS34335	COG0302	gtp cyclohydrolase
HUT15_RS34345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT15_RS34355	COG4948	Mandelate Racemase Muconate Lactonizing
HUT15_RS34365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT15_RS34395	COG2197	response regulator
HUT15_RS34400	COG4585	Histidine kinase
HUT15_RS34430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT15_RS34440	COG0488	(ABC) transporter
HUT15_RS34450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT15_RS34460	COG1470	cell adhesion involved in biofilm formation
HUT15_RS34460	COG0366	Alpha amylase catalytic
HUT15_RS34465	COG1609	Transcriptional regulator
HUT15_RS34470	COG2186	Transcriptional regulator
HUT15_RS34475	COG4948	Mandelate Racemase Muconate Lactonizing
HUT15_RS34480	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS34490	COG3618	amidohydrolase
HUT15_RS34500	COG0154	amidase activity
HUT15_RS34520	COG1621	beta-fructofuranosidase activity
HUT15_RS34530	COG1175	transmembrane transport
HUT15_RS34535	COG0395	ABC-type sugar transport system, permease component
HUT15_RS34545	COG1609	Transcriptional regulator
HUT15_RS34565	COG3408	Glycogen debranching enzyme
HUT15_RS34580	COG4221	oxidoreductase activity
HUT15_RS34585	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS34615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT15_RS34640	COG2205	protein histidine kinase activity
HUT15_RS34645	COG0745	RESPONSE REGULATOR receiver
HUT15_RS34655	COG1131	(ABC) transporter
HUT15_RS34660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT15_RS34680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HUT15_RS34700	COG0583	DNA-binding transcription factor activity
HUT15_RS34725	COG1733	regulation of RNA biosynthetic process
HUT15_RS34735	COG0456	acetyltransferase
HUT15_RS34735	COG3153	acetyltransferase
HUT15_RS34765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT15_RS34780	COG2197	response regulator
HUT15_RS34835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT15_RS34835	COG1017	nitric oxide dioxygenase activity
HUT15_RS34890	COG1595	DNA-templated transcription, initiation
HUT15_RS34910	COG1053	succinate dehydrogenase
HUT15_RS34920	COG1764	response to oxidative stress
HUT15_RS34925	COG1595	DNA-templated transcription, initiation
HUT15_RS34965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT15_RS34985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT15_RS35005	COG0477	Major facilitator Superfamily
HUT15_RS35035	COG1672	PFAM Archaeal ATPase
HUT15_RS35035	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT15_RS35050	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT15_RS35050	COG1672	PFAM Archaeal ATPase
HUT15_RS35070	COG0778	Nitroreductase
HUT15_RS35080	COG1672	PFAM Archaeal ATPase
HUT15_RS35080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT15_RS35085	COG1595	DNA-templated transcription, initiation
HUT15_RS35090	COG1846	Transcriptional regulator
HUT15_RS35095	COG0640	Transcriptional regulator
HUT15_RS35120	COG0477	Major facilitator Superfamily
HUT15_RS35125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT15_RS35145	COG1672	PFAM Archaeal ATPase
HUT15_RS35145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT15_RS35195	COG2837	iron assimilation
HUT15_RS35245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT15_RS35260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUT15_RS35260	COG2070	2-Nitropropane dioxygenase
HUT15_RS35325	COG0702	epimerase
HUT15_RS35355	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HUT15_RS35395	COG1309	transcriptional regulator
HUT15_RS35400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUT15_RS35405	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT15_RS35415	COG0726	polysaccharide deacetylase
HUT15_RS35435	COG1028	Short-chain dehydrogenase reductase Sdr
HUT15_RS35450	COG2318	DinB family
HUT15_RS35575	COG0069	glutamate synthase activity
HUT15_RS35610	COG0640	Transcriptional regulator
HUT15_RS35620	COG1316	TRANSCRIPTIONal
HUT15_RS35625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT15_RS35650	COG0367	asparagine synthase
HUT15_RS35695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT15_RS35705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT15_RS35730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT15_RS36050	COG1196	nuclear chromosome segregation
HUT15_RS36050	COG0741	lytic transglycosylase activity
HUT15_RS36050	COG0739	heme binding
HUT15_RS36085	COG1857	crispr-associated protein
HUT15_RS36100	COG1518	maintenance of DNA repeat elements
HUT15_RS36200	COG1937	Protein conserved in bacteria
HUT15_RS36235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT15_RS36235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT15_RS36250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT15_RS36255	COG1937	Protein conserved in bacteria
HUT15_RS36355	COG2814	Major facilitator Superfamily
HUT15_RS36410	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT15_RS36415	COG0702	epimerase
HUT15_RS36555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT15_RS36565	COG4221	oxidoreductase activity
HUT15_RS36655	COG1857	crispr-associated protein
HUT15_RS36715	COG2814	Major facilitator Superfamily
HUT15_RS36905	COG2755	lipolytic protein G-D-S-L family
HUT15_RS36930	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUT15_RS36945	COG0492	ferredoxin-NADP+ reductase activity
HUT15_RS37115	COG1192	Involved in chromosome partitioning
HUT15_RS37140	COG1793	dna ligase
HUT15_RS37170	COG3547	Transposase (IS116 IS110 IS902 family)
HUT15_RS37190	COG2755	lipolytic protein G-D-S-L family