locus-tag	class	description
HUT18_RS00030	COG0640	Transcriptional regulator
HUT18_RS00060	COG4977	sequence-specific DNA binding
HUT18_RS00060	COG1917	Cupin 2, conserved barrel domain protein
HUT18_RS00115	COG2205	protein histidine kinase activity
HUT18_RS00125	COG0745	RESPONSE REGULATOR receiver
HUT18_RS00140	COG1136	(ABC) transporter
HUT18_RS00140	COG0577	efflux transmembrane transporter activity
HUT18_RS00145	COG1136	(ABC) transporter
HUT18_RS00145	COG0577	efflux transmembrane transporter activity
HUT18_RS00150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS00165	COG3848	Pyruvate phosphate dikinase
HUT18_RS00165	COG0574	Belongs to the PEP-utilizing enzyme family
HUT18_RS00200	COG2814	Major facilitator Superfamily
HUT18_RS00225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS00235	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS00240	COG3842	ATPase activity
HUT18_RS00245	COG1653	transport
HUT18_RS00255	COG0395	ABC-type sugar transport system, permease component
HUT18_RS00260	COG0583	DNA-binding transcription factor activity
HUT18_RS00300	COG0248	Ppx GppA phosphatase
HUT18_RS00350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT18_RS00365	COG2226	methyltransferase
HUT18_RS00370	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HUT18_RS00390	COG4221	oxidoreductase activity
HUT18_RS00405	COG0800	Aldolase
HUT18_RS00410	COG0837	glucose binding
HUT18_RS00420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUT18_RS00440	COG2329	Antibiotic biosynthesis monooxygenase
HUT18_RS00460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT18_RS00475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUT18_RS00475	COG0825	malonyl-CoA metabolic process
HUT18_RS00480	COG0511	ligase activity, forming carbon-carbon bonds
HUT18_RS00485	COG0439	Biotin carboxylase
HUT18_RS00495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT18_RS00510	COG1175	transmembrane transport
HUT18_RS00515	COG3833	ABC-type maltose transport systems, permease component
HUT18_RS00520	COG0366	Alpha amylase catalytic
HUT18_RS00570	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUT18_RS00575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUT18_RS00580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUT18_RS00590	COG0531	amino acid
HUT18_RS00630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT18_RS00640	COG2223	nitrite transmembrane transporter activity
HUT18_RS00655	COG2318	DinB family
HUT18_RS00685	COG3629	intracellular signal transduction
HUT18_RS00685	COG3903	Transcriptional regulator
HUT18_RS00700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT18_RS00710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT18_RS00715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT18_RS00725	COG1090	epimerase
HUT18_RS00755	COG3559	Exporter of polyketide antibiotics
HUT18_RS00760	COG1131	(ABC) transporter
HUT18_RS00775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT18_RS00855	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT18_RS00875	COG1063	alcohol dehydrogenase
HUT18_RS00880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT18_RS00885	COG1834	amidinotransferase
HUT18_RS00915	COG0330	HflC and HflK could
HUT18_RS00970	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS00980	COG2815	serine threonine protein kinase
HUT18_RS00980	COG0515	serine threonine protein kinase
HUT18_RS01020	COG1090	epimerase
HUT18_RS01035	COG3437	response regulator, receiver
HUT18_RS01040	COG4999	Histidine kinase
HUT18_RS01040	COG2205	protein histidine kinase activity
HUT18_RS01040	COG3437	response regulator, receiver
HUT18_RS01040	COG3850	Histidine kinase
HUT18_RS01055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS01055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS01055	COG1703	isobutyryl-CoA mutase activity
HUT18_RS01060	COG0583	DNA-binding transcription factor activity
HUT18_RS01070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT18_RS01080	COG0384	phenazine biosynthesis protein PhzF
HUT18_RS01095	COG0151	Belongs to the GarS family
HUT18_RS01115	COG2376	Dihydroxyacetone kinase
HUT18_RS01120	COG1461	Dihydroxyacetone kinase
HUT18_RS01140	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT18_RS01140	COG1902	pentaerythritol trinitrate reductase activity
HUT18_RS01155	COG0435	Glutathione S-transferase
HUT18_RS01175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUT18_RS01180	COG1215	transferase activity, transferring glycosyl groups
HUT18_RS01210	COG1129	ABC transporter
HUT18_RS01240	COG0395	ABC-type sugar transport system, permease component
HUT18_RS01245	COG1175	transmembrane transport
HUT18_RS01260	COG2188	Transcriptional regulator
HUT18_RS01270	COG1349	DNA-binding transcription factor activity
HUT18_RS01290	COG0577	efflux transmembrane transporter activity
HUT18_RS01295	COG1136	(ABC) transporter
HUT18_RS01315	COG1063	alcohol dehydrogenase
HUT18_RS01320	COG2188	Transcriptional regulator
HUT18_RS01335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUT18_RS01350	COG1940	carbohydrate kinase activity
HUT18_RS01365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT18_RS01370	COG1349	DNA-binding transcription factor activity
HUT18_RS01390	COG0596	Alpha beta hydrolase
HUT18_RS01410	COG2197	response regulator
HUT18_RS01415	COG4585	Histidine kinase
HUT18_RS01430	COG0445	tRNA wobble uridine modification
HUT18_RS01435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT18_RS01440	COG1660	Displays ATPase and GTPase activities
HUT18_RS01460	COG0515	serine threonine protein kinase
HUT18_RS01470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUT18_RS01490	COG0204	Acyl-transferase
HUT18_RS01520	COG0584	glycerophosphoryl diester phosphodiesterase
HUT18_RS01545	COG0671	phosphoesterase, PA-phosphatase related
HUT18_RS01560	COG1309	transcriptional regulator
HUT18_RS01565	COG0493	'glutamate synthase
HUT18_RS01585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT18_RS01590	COG0590	tRNA wobble adenosine to inosine editing
HUT18_RS01600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT18_RS01610	COG0662	Cupin 2, conserved barrel domain protein
HUT18_RS01615	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS01630	COG2040	homocysteine
HUT18_RS01640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS01660	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS01670	COG4981	capsule polysaccharide biosynthetic process
HUT18_RS01710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT18_RS01715	COG2971	BadF BadG BcrA BcrD
HUT18_RS01725	COG2706	6-phosphogluconolactonase activity
HUT18_RS01740	COG3321	synthase
HUT18_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS01740	COG0604	alcohol dehydrogenase
HUT18_RS01770	COG0346	lactoylglutathione lyase activity
HUT18_RS01775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT18_RS01780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT18_RS01785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT18_RS01800	COG0432	Pfam Uncharacterised protein family UPF0047
HUT18_RS01810	COG0492	ferredoxin-NADP+ reductase activity
HUT18_RS01815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUT18_RS01820	COG1132	(ABC) transporter
HUT18_RS01825	COG1846	Transcriptional regulator
HUT18_RS01840	COG1132	(ABC) transporter
HUT18_RS01845	COG1132	(ABC) transporter
HUT18_RS01870	COG2018	Roadblock/LC7 domain
HUT18_RS01890	COG0791	NLP P60 protein
HUT18_RS01895	COG2172	sigma factor antagonist activity
HUT18_RS01905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUT18_RS01910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT18_RS01915	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUT18_RS01955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT18_RS01975	COG2203	Gaf domain
HUT18_RS01975	COG4585	Histidine kinase
HUT18_RS01980	COG2197	response regulator
HUT18_RS01985	COG1595	DNA-templated transcription, initiation
HUT18_RS01990	COG2267	carboxylic ester hydrolase activity
HUT18_RS02005	COG0346	lactoylglutathione lyase activity
HUT18_RS02020	COG0626	cystathionine gamma-synthase activity
HUT18_RS02040	COG1522	sequence-specific DNA binding
HUT18_RS02045	COG0419	ATPase involved in DNA repair
HUT18_RS02050	COG0420	3'-5' exonuclease activity
HUT18_RS02055	COG1739	Uncharacterized protein family UPF0029
HUT18_RS02080	COG1832	CoA-binding protein
HUT18_RS02095	COG0110	maltose O-acetyltransferase activity
HUT18_RS02140	COG1595	DNA-templated transcription, initiation
HUT18_RS02145	COG0346	lactoylglutathione lyase activity
HUT18_RS02185	COG1968	undecaprenyl-diphosphatase activity
HUT18_RS02205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUT18_RS02220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT18_RS02225	COG0747	negative chemotaxis
HUT18_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS02260	COG0583	DNA-binding transcription factor activity
HUT18_RS02265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUT18_RS02280	COG0697	spore germination
HUT18_RS02290	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS02295	COG0174	glutamine synthetase
HUT18_RS02300	COG2186	Transcriptional regulator
HUT18_RS02305	COG0531	amino acid
HUT18_RS02310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUT18_RS02330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT18_RS02330	COG0515	serine threonine protein kinase
HUT18_RS02335	COG0515	serine threonine protein kinase
HUT18_RS02335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT18_RS02385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT18_RS02385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT18_RS02395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT18_RS02435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT18_RS02460	COG1263	PTS System
HUT18_RS02460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUT18_RS02460	COG2190	(PTS) system
HUT18_RS02465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT18_RS02475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT18_RS02490	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUT18_RS02495	COG5001	Diguanylate cyclase
HUT18_RS02495	COG5002	protein histidine kinase activity
HUT18_RS02500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT18_RS02505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT18_RS02510	COG1309	transcriptional regulator
HUT18_RS02540	COG2018	Roadblock/LC7 domain
HUT18_RS02580	COG2814	Major facilitator Superfamily
HUT18_RS02585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUT18_RS02590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUT18_RS02595	COG1984	allophanate hydrolase subunit 2
HUT18_RS02605	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS02635	COG2186	Transcriptional regulator
HUT18_RS02645	COG0584	glycerophosphoryl diester phosphodiesterase
HUT18_RS02660	COG0463	Glycosyl transferase, family 2
HUT18_RS02725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUT18_RS02730	COG0140	phosphoribosyl-ATP diphosphatase activity
HUT18_RS02735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUT18_RS02740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT18_RS02740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT18_RS02745	COG3201	nicotinamide mononucleotide transporter
HUT18_RS02760	COG0702	epimerase
HUT18_RS02765	COG0738	Major facilitator superfamily
HUT18_RS02780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT18_RS02805	COG2390	Transcriptional regulator
HUT18_RS02810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUT18_RS02815	COG2409	Drug exporters of the RND superfamily
HUT18_RS02825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUT18_RS02860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT18_RS02880	COG0284	orotidine-5'-phosphate decarboxylase activity
HUT18_RS02885	COG0167	dihydroorotate dehydrogenase activity
HUT18_RS02890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT18_RS02895	COG0505	Belongs to the CarA family
HUT18_RS02905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT18_RS02910	COG0540	Belongs to the ATCase OTCase family
HUT18_RS02915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUT18_RS02925	COG0702	epimerase
HUT18_RS02935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUT18_RS02940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUT18_RS02945	COG0006	proline dipeptidase activity
HUT18_RS02955	COG1473	amidohydrolase
HUT18_RS02975	COG1131	(ABC) transporter
HUT18_RS03010	COG3629	intracellular signal transduction
HUT18_RS03010	COG3903	Transcriptional regulator
HUT18_RS03015	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT18_RS03020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT18_RS03025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT18_RS03030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUT18_RS03035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUT18_RS03040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUT18_RS03045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT18_RS03060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT18_RS03075	COG0124	histidyl-tRNA synthetase
HUT18_RS03085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUT18_RS03090	COG1196	nuclear chromosome segregation
HUT18_RS03095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT18_RS03100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT18_RS03105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT18_RS03110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT18_RS03120	COG2255	four-way junction helicase activity
HUT18_RS03125	COG0632	four-way junction helicase activity
HUT18_RS03130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUT18_RS03135	COG0217	transcriptional regulatory protein
HUT18_RS03140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUT18_RS03145	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUT18_RS03155	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS03160	COG1560	Kdo2-lipid A biosynthetic process
HUT18_RS03165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUT18_RS03185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT18_RS03200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUT18_RS03260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT18_RS03315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT18_RS03320	COG1648	precorrin-2 dehydrogenase activity
HUT18_RS03320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT18_RS03325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT18_RS03340	COG1464	Belongs to the NlpA lipoprotein family
HUT18_RS03345	COG2011	ABC-type metal ion transport system permease component
HUT18_RS03350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT18_RS03375	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS03375	COG0204	Acyl-transferase
HUT18_RS03385	COG0165	Argininosuccinate lyase
HUT18_RS03390	COG0137	argininosuccinate synthase activity
HUT18_RS03395	COG3189	MarR family transcriptional regulator
HUT18_RS03430	COG1438	arginine binding
HUT18_RS03435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT18_RS03440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT18_RS03445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUT18_RS03450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUT18_RS03525	COG2226	methyltransferase
HUT18_RS03560	COG0604	alcohol dehydrogenase
HUT18_RS03570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT18_RS03575	COG0697	spore germination
HUT18_RS03585	COG1649	PFAM Uncharacterised BCR, COG1649
HUT18_RS03610	COG0072	phenylalanine-tRNA ligase activity
HUT18_RS03610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT18_RS03615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUT18_RS03620	COG5002	protein histidine kinase activity
HUT18_RS03625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT18_RS03630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUT18_RS03635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUT18_RS03640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUT18_RS03675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT18_RS03690	COG0564	pseudouridine synthase activity
HUT18_RS03730	COG0805	protein transport
HUT18_RS03735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT18_RS03755	COG2378	regulation of single-species biofilm formation
HUT18_RS03765	COG0545	Peptidyl-prolyl cis-trans isomerase
HUT18_RS03770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT18_RS03780	COG1609	Transcriptional regulator
HUT18_RS03785	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT18_RS03790	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT18_RS03805	COG4122	O-methyltransferase activity
HUT18_RS03810	COG1222	aaa ATPase
HUT18_RS03830	COG0517	IMP dehydrogenase activity
HUT18_RS03830	COG1994	Peptidase M50
HUT18_RS03840	COG2197	response regulator
HUT18_RS03855	COG1410	methionine synthase
HUT18_RS03855	COG0646	methionine synthase
HUT18_RS03860	COG1414	Transcriptional regulator
HUT18_RS03865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT18_RS03870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT18_RS03875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT18_RS03880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS03890	COG0366	Alpha amylase catalytic
HUT18_RS03890	COG1470	cell adhesion involved in biofilm formation
HUT18_RS03895	COG0215	cysteine-tRNA ligase activity
HUT18_RS03910	COG0406	alpha-ribazole phosphatase activity
HUT18_RS03915	COG0598	Magnesium transport protein CorA
HUT18_RS03925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS03930	COG0667	Aldo Keto reductase
HUT18_RS03955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT18_RS03965	COG3012	SEC-C Motif Domain Protein
HUT18_RS03970	COG2186	Transcriptional regulator
HUT18_RS03975	COG3265	gluconokinase activity
HUT18_RS04000	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT18_RS04005	COG2149	membrane
HUT18_RS04030	COG3876	Protein conserved in bacteria
HUT18_RS04045	COG3629	intracellular signal transduction
HUT18_RS04045	COG3903	Transcriptional regulator
HUT18_RS04050	COG0072	phenylalanine-tRNA ligase activity
HUT18_RS04050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT18_RS04055	COG0789	Transcriptional regulator
HUT18_RS04075	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS04110	COG2851	Citrate transporter
HUT18_RS04115	COG0243	molybdopterin cofactor binding
HUT18_RS04120	COG1309	transcriptional regulator
HUT18_RS04125	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUT18_RS04130	COG2188	Transcriptional regulator
HUT18_RS04140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT18_RS04150	COG2755	lipolytic protein G-D-S-L family
HUT18_RS04160	COG1725	Transcriptional regulator
HUT18_RS04195	COG0587	DNA-directed DNA polymerase activity
HUT18_RS04230	COG0765	amino acid transport
HUT18_RS04245	COG1799	cell septum assembly
HUT18_RS04250	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS04255	COG0477	Major facilitator Superfamily
HUT18_RS04260	COG0671	phosphoesterase, PA-phosphatase related
HUT18_RS04270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT18_RS04280	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS04295	COG1160	GTP binding
HUT18_RS04305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUT18_RS04320	COG3541	Predicted nucleotidyltransferase
HUT18_RS04345	COG1187	pseudouridine synthase activity
HUT18_RS04350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUT18_RS04355	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUT18_RS04370	COG0686	Belongs to the AlaDH PNT family
HUT18_RS04385	COG0494	nUDIX hydrolase
HUT18_RS04390	COG0504	CTP synthase activity
HUT18_RS04395	COG3387	PFAM Glycoside hydrolase 15-related
HUT18_RS04405	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS04410	COG0497	DNA recombination
HUT18_RS04415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT18_RS04435	COG1120	ATPase activity
HUT18_RS04440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT18_RS04445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT18_RS04450	COG0647	UMP catabolic process
HUT18_RS04480	COG2094	Belongs to the DNA glycosylase MPG family
HUT18_RS04490	COG1881	PFAM PEBP family protein
HUT18_RS04510	COG1119	ATPase activity
HUT18_RS04525	COG2197	response regulator
HUT18_RS04530	COG4585	Histidine kinase
HUT18_RS04540	COG1716	ATPase activity
HUT18_RS04540	COG1131	(ABC) transporter
HUT18_RS04540	COG0842	Transport permease protein
HUT18_RS04545	COG3830	Belongs to the UPF0237 family
HUT18_RS04545	COG0560	Phosphoserine phosphatase
HUT18_RS04565	COG2186	Transcriptional regulator
HUT18_RS04585	COG0312	modulator of DNA gyrase
HUT18_RS04595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUT18_RS04615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT18_RS04620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT18_RS04635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT18_RS04650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT18_RS04715	COG0488	(ABC) transporter
HUT18_RS04735	COG0235	Class ii aldolase
HUT18_RS04755	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUT18_RS04760	COG1492	cobalamin metabolic process
HUT18_RS04775	COG1797	cobyrinic acid a,c-diamide synthase activity
HUT18_RS04800	COG0765	amino acid transport
HUT18_RS04815	COG0456	acetyltransferase
HUT18_RS04820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT18_RS04825	COG1917	Cupin 2, conserved barrel domain protein
HUT18_RS04830	COG5285	phytanoyl-CoA dioxygenase
HUT18_RS04835	COG1846	Transcriptional regulator
HUT18_RS04915	COG2171	N-acyltransferase activity
HUT18_RS04920	COG2076	Multidrug Resistance protein
HUT18_RS04950	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT18_RS04955	COG0822	iron-sulfur transferase activity
HUT18_RS04960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT18_RS04965	COG0396	ATPase activity
HUT18_RS04975	COG0719	Fe-S assembly protein
HUT18_RS04990	COG1131	(ABC) transporter
HUT18_RS05000	COG1612	heme a metabolic process
HUT18_RS05015	COG0109	protoheme IX farnesyltransferase activity
HUT18_RS05025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT18_RS05040	COG0363	glucosamine-6-phosphate deaminase activity
HUT18_RS05050	COG0166	Belongs to the GPI family
HUT18_RS05060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT18_RS05065	COG0149	triose-phosphate isomerase activity
HUT18_RS05070	COG0126	phosphoglycerate kinase activity
HUT18_RS05075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT18_RS05080	COG1481	regulation of sporulation
HUT18_RS05085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT18_RS05090	COG1660	Displays ATPase and GTPase activities
HUT18_RS05095	COG0322	excinuclease ABC activity
HUT18_RS05125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT18_RS05140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUT18_RS05145	COG0387	Pfam Sodium calcium exchanger
HUT18_RS05165	COG0556	nucleotide-excision repair
HUT18_RS05175	COG0584	glycerophosphoryl diester phosphodiesterase
HUT18_RS05180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT18_RS05185	COG2313	pseudouridylate synthase activity
HUT18_RS05190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT18_RS05195	COG0598	Magnesium transport protein CorA
HUT18_RS05275	COG0583	DNA-binding transcription factor activity
HUT18_RS05285	COG2226	methyltransferase
HUT18_RS05300	COG0237	dephospho-CoA kinase activity
HUT18_RS05305	COG2814	Major facilitator Superfamily
HUT18_RS05320	COG2368	4-hydroxyphenylacetate
HUT18_RS05325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUT18_RS05330	COG0367	asparagine synthase
HUT18_RS05350	COG0583	DNA-binding transcription factor activity
HUT18_RS05355	COG2197	response regulator
HUT18_RS05360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT18_RS05370	COG0747	negative chemotaxis
HUT18_RS05390	COG0539	negative regulation of cytoplasmic translation
HUT18_RS05400	COG1643	Atp-dependent helicase
HUT18_RS05425	COG2050	protein possibly involved in aromatic compounds catabolism
HUT18_RS05500	COG0287	Prephenate dehydrogenase
HUT18_RS05500	COG1605	Chorismate mutase
HUT18_RS05515	COG0789	Transcriptional regulator
HUT18_RS05520	COG0366	Alpha amylase catalytic
HUT18_RS05520	COG1470	cell adhesion involved in biofilm formation
HUT18_RS05570	COG0067	glutamate synthase
HUT18_RS05570	COG0069	glutamate synthase activity
HUT18_RS05570	COG0070	glutamate synthase
HUT18_RS05580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT18_RS05585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUT18_RS05595	COG0159	tryptophan synthase activity
HUT18_RS05600	COG0133	tryptophan synthase activity
HUT18_RS05610	COG0134	indole-3-glycerol-phosphate synthase activity
HUT18_RS05630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUT18_RS05635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT18_RS05645	COG2409	Drug exporters of the RND superfamily
HUT18_RS05650	COG0107	imidazoleglycerol-phosphate synthase activity
HUT18_RS05655	COG0251	oxidation-reduction process
HUT18_RS05660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUT18_RS05665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUT18_RS05675	COG0131	Imidazoleglycerol-phosphate dehydratase
HUT18_RS05680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT18_RS05685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUT18_RS05710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUT18_RS05740	COG0587	DNA-directed DNA polymerase activity
HUT18_RS05805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUT18_RS05815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUT18_RS05830	COG1799	cell septum assembly
HUT18_RS05845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUT18_RS05850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUT18_RS05855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUT18_RS05865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT18_RS05870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT18_RS05880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT18_RS05895	COG0275	rRNA processing
HUT18_RS05905	COG0714	Associated with various cellular activities
HUT18_RS05935	COG1129	ABC transporter
HUT18_RS05945	COG1309	transcriptional regulator
HUT18_RS05980	COG0352	thiamine-phosphate diphosphorylase activity
HUT18_RS06000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT18_RS06000	COG2022	thiamine diphosphate biosynthetic process
HUT18_RS06010	COG2022	thiamine diphosphate biosynthetic process
HUT18_RS06015	COG0515	serine threonine protein kinase
HUT18_RS06015	COG2815	serine threonine protein kinase
HUT18_RS06020	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT18_RS06025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT18_RS06030	COG2193	ferroxidase activity
HUT18_RS06035	COG0243	molybdopterin cofactor binding
HUT18_RS06040	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT18_RS06060	COG0205	6-phosphofructokinase activity
HUT18_RS06070	COG2197	response regulator
HUT18_RS06075	COG4585	Histidine kinase
HUT18_RS06100	COG1940	carbohydrate kinase activity
HUT18_RS06110	COG0003	Pfam Anion-transporting ATPase
HUT18_RS06130	COG1022	Amp-dependent synthetase and ligase
HUT18_RS06135	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS06180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT18_RS06185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT18_RS06190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT18_RS06195	COG0723	plastoquinol--plastocyanin reductase activity
HUT18_RS06200	COG2010	Cytochrome c
HUT18_RS06205	COG1845	cytochrome c oxidase, subunit III
HUT18_RS06215	COG1376	ErfK ybiS ycfS ynhG family protein
HUT18_RS06225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT18_RS06230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUT18_RS06240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT18_RS06260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUT18_RS06280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUT18_RS06285	COG2197	response regulator
HUT18_RS06290	COG4585	Histidine kinase
HUT18_RS06350	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT18_RS06355	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUT18_RS06360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT18_RS06365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT18_RS06370	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT18_RS06380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT18_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS06410	COG1090	epimerase
HUT18_RS06425	COG0321	lipoyl(octanoyl) transferase activity
HUT18_RS06430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUT18_RS06490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT18_RS06495	COG0601	transmembrane transport
HUT18_RS06505	COG1940	carbohydrate kinase activity
HUT18_RS06530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT18_RS06570	COG0745	RESPONSE REGULATOR receiver
HUT18_RS06585	COG4585	Histidine kinase
HUT18_RS06590	COG2197	response regulator
HUT18_RS06600	COG0366	Alpha amylase catalytic
HUT18_RS06610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUT18_RS06625	COG0174	glutamine synthetase
HUT18_RS06645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUT18_RS06645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT18_RS06650	COG2814	Major facilitator Superfamily
HUT18_RS06665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT18_RS06680	COG1994	Peptidase M50
HUT18_RS06725	COG5398	heme oxygenase
HUT18_RS06800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT18_RS06805	COG2814	Major facilitator Superfamily
HUT18_RS06905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUT18_RS06910	COG3540	Alkaline phosphatase
HUT18_RS06950	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS07005	COG0346	lactoylglutathione lyase activity
HUT18_RS07010	COG0640	Transcriptional regulator
HUT18_RS07015	COG2318	DinB family
HUT18_RS07030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT18_RS07040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT18_RS07075	COG1674	ftsk spoiiie
HUT18_RS07135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUT18_RS07145	COG0732	type I restriction modification DNA specificity domain
HUT18_RS07170	COG2815	serine threonine protein kinase
HUT18_RS07170	COG0515	serine threonine protein kinase
HUT18_RS07200	COG3285	dna ligase
HUT18_RS07200	COG1793	dna ligase
HUT18_RS07230	COG3022	response to hydroperoxide
HUT18_RS07245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUT18_RS07260	COG2030	dehydratase
HUT18_RS07265	COG4585	Histidine kinase
HUT18_RS07270	COG2197	response regulator
HUT18_RS07275	COG0477	Major facilitator Superfamily
HUT18_RS07285	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUT18_RS07305	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS07310	COG1309	transcriptional regulator
HUT18_RS07330	COG3845	ABC transporter
HUT18_RS07400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT18_RS07410	COG1127	ABC transporter
HUT18_RS07435	COG4122	O-methyltransferase activity
HUT18_RS07545	COG0586	Pfam SNARE associated Golgi protein
HUT18_RS07555	COG1358	cellular component organization or biogenesis
HUT18_RS07600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT18_RS07605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT18_RS07620	COG1595	DNA-templated transcription, initiation
HUT18_RS07625	COG0477	Major facilitator Superfamily
HUT18_RS07630	COG1309	transcriptional regulator
HUT18_RS07645	COG0667	Aldo Keto reductase
HUT18_RS07650	COG0789	Transcriptional regulator
HUT18_RS07660	COG1309	transcriptional regulator
HUT18_RS07685	COG1741	Belongs to the pirin family
HUT18_RS07700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT18_RS07705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT18_RS07710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT18_RS07745	COG2130	NADP-dependent
HUT18_RS07770	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS07780	COG1077	Cell shape determining protein MreB Mrl
HUT18_RS07835	COG1857	crispr-associated protein
HUT18_RS07890	COG0515	serine threonine protein kinase
HUT18_RS07945	COG1070	Carbohydrate kinase
HUT18_RS07970	COG1073	alpha beta
HUT18_RS07980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT18_RS07985	COG0358	DNA primase activity
HUT18_RS07995	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT18_RS08010	COG0243	molybdopterin cofactor binding
HUT18_RS08045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT18_RS08050	COG2146	nitrite reductase [NAD(P)H] activity
HUT18_RS08050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT18_RS08080	COG0574	Belongs to the PEP-utilizing enzyme family
HUT18_RS08080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT18_RS08125	COG2356	endonuclease I
HUT18_RS08140	COG0423	glycine-tRNA ligase activity
HUT18_RS08145	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT18_RS08145	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUT18_RS08150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT18_RS08155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT18_RS08165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT18_RS08170	COG1381	Involved in DNA repair and RecF pathway recombination
HUT18_RS08180	COG2186	Transcriptional regulator
HUT18_RS08185	COG0747	negative chemotaxis
HUT18_RS08195	COG0444	Belongs to the ABC transporter superfamily
HUT18_RS08200	COG4608	Belongs to the ABC transporter superfamily
HUT18_RS08205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT18_RS08215	COG2197	response regulator
HUT18_RS08220	COG4585	Histidine kinase
HUT18_RS08225	COG2409	Drug exporters of the RND superfamily
HUT18_RS08235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT18_RS08260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUT18_RS08290	COG2315	Protein conserved in bacteria
HUT18_RS08300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT18_RS08310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT18_RS08310	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT18_RS08315	COG1486	melibiose metabolic process
HUT18_RS08325	COG1234	tRNA 3'-trailer cleavage
HUT18_RS08330	COG0537	adenosine 5'-monophosphoramidase activity
HUT18_RS08335	COG0793	Belongs to the peptidase S41A family
HUT18_RS08335	COG4946	Tricorn protease homolog
HUT18_RS08355	COG0484	heat shock protein binding
HUT18_RS08360	COG1420	regulation of RNA biosynthetic process
HUT18_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS08390	COG0481	GTPase activity
HUT18_RS08395	COG0268	Binds directly to 16S ribosomal RNA
HUT18_RS08415	COG2353	YceI-like domain
HUT18_RS08435	COG1307	EDD domain protein, DegV family
HUT18_RS08445	COG0495	leucyl-tRNA aminoacylation
HUT18_RS08465	COG0477	Major facilitator Superfamily
HUT18_RS08480	COG0588	phosphoglycerate mutase activity
HUT18_RS08485	COG0799	negative regulation of ribosome biogenesis
HUT18_RS08495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUT18_RS08505	COG0501	Belongs to the peptidase M48B family
HUT18_RS08520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT18_RS08530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUT18_RS08540	COG2133	pyrroloquinoline quinone binding
HUT18_RS08540	COG5183	chlorophyll binding
HUT18_RS08550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT18_RS08555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUT18_RS08560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUT18_RS08565	COG1530	ribonuclease E activity
HUT18_RS08605	COG0772	Belongs to the SEDS family
HUT18_RS08610	COG0768	penicillin binding
HUT18_RS08625	COG1077	Cell shape determining protein MreB Mrl
HUT18_RS08630	COG0105	UTP biosynthetic process
HUT18_RS08640	COG0285	dihydrofolate synthase activity
HUT18_RS08645	COG0525	valine-tRNA ligase activity
HUT18_RS08660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT18_RS08665	COG0740	serine-type endopeptidase activity
HUT18_RS08670	COG0740	serine-type endopeptidase activity
HUT18_RS08675	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUT18_RS08695	COG3594	Acyltransferase
HUT18_RS08720	COG4552	Acetyltransferase involved in intracellular survival and related
HUT18_RS08740	COG1268	BioY protein
HUT18_RS08745	COG1113	amino acid transport
HUT18_RS08750	COG0745	RESPONSE REGULATOR receiver
HUT18_RS08765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUT18_RS08770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT18_RS08825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT18_RS08850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUT18_RS08850	COG3291	Pkd domain containing protein
HUT18_RS08860	COG0668	transmembrane transport
HUT18_RS08870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT18_RS08930	COG0629	single-stranded DNA binding
HUT18_RS08990	COG0574	Belongs to the PEP-utilizing enzyme family
HUT18_RS08990	COG3848	Pyruvate phosphate dikinase
HUT18_RS09025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT18_RS09040	COG0642	Histidine kinase
HUT18_RS09070	COG3938	Belongs to the proline racemase family
HUT18_RS09075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT18_RS09135	COG1595	DNA-templated transcription, initiation
HUT18_RS09165	COG0676	glucose-6-phosphate 1-epimerase activity
HUT18_RS09170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS09195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS09220	COG0745	RESPONSE REGULATOR receiver
HUT18_RS09225	COG1309	transcriptional regulator
HUT18_RS09305	COG2226	methyltransferase
HUT18_RS09345	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS09360	COG0583	DNA-binding transcription factor activity
HUT18_RS09370	COG0183	Belongs to the thiolase family
HUT18_RS09385	COG0477	Major facilitator Superfamily
HUT18_RS09395	COG1309	transcriptional regulator
HUT18_RS09405	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS09430	COG0456	acetyltransferase
HUT18_RS09445	COG1064	alcohol dehydrogenase
HUT18_RS09455	COG1376	ErfK ybiS ycfS ynhG family protein
HUT18_RS09470	COG2986	histidine ammonia-lyase
HUT18_RS09495	COG1024	Enoyl-CoA hydratase
HUT18_RS09500	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT18_RS09510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT18_RS09520	COG0424	maF-like protein
HUT18_RS09530	COG4770	biotin carboxylase activity
HUT18_RS09545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT18_RS09545	COG2010	Cytochrome c
HUT18_RS09565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT18_RS09590	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS09595	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS09610	COG1595	DNA-templated transcription, initiation
HUT18_RS09615	COG0745	RESPONSE REGULATOR receiver
HUT18_RS09620	COG2205	protein histidine kinase activity
HUT18_RS09645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT18_RS09655	COG0583	DNA-binding transcription factor activity
HUT18_RS09660	COG2814	Major facilitator Superfamily
HUT18_RS09690	COG0515	serine threonine protein kinase
HUT18_RS09690	COG2815	serine threonine protein kinase
HUT18_RS09695	COG1309	transcriptional regulator
HUT18_RS09700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT18_RS09715	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS09775	COG0542	response to heat
HUT18_RS09785	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT18_RS09815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT18_RS09820	COG0589	response to stress
HUT18_RS09825	COG4977	sequence-specific DNA binding
HUT18_RS09830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUT18_RS09860	COG2826	transposase and inactivated derivatives, IS30 family
HUT18_RS09890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT18_RS09910	COG1278	Cold shock
HUT18_RS09915	COG0673	inositol 2-dehydrogenase activity
HUT18_RS09990	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT18_RS10025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS10065	COG0154	amidase activity
HUT18_RS10085	COG0765	amino acid transport
HUT18_RS10090	COG0765	amino acid transport
HUT18_RS10095	COG1126	abc transporter atp-binding protein
HUT18_RS10140	COG2186	Transcriptional regulator
HUT18_RS10160	COG2826	transposase and inactivated derivatives, IS30 family
HUT18_RS10240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT18_RS10250	COG2188	Transcriptional regulator
HUT18_RS10275	COG0673	inositol 2-dehydrogenase activity
HUT18_RS10280	COG0706	membrane insertase activity
HUT18_RS10355	COG2733	membrane
HUT18_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS10370	COG4585	Histidine kinase
HUT18_RS10375	COG2197	response regulator
HUT18_RS10385	COG4555	ABC transporter
HUT18_RS10400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT18_RS10435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUT18_RS10445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUT18_RS10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUT18_RS10455	COG1234	tRNA 3'-trailer cleavage
HUT18_RS10495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT18_RS10500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT18_RS10515	COG1113	amino acid transport
HUT18_RS10525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUT18_RS10535	COG1335	isochorismatase
HUT18_RS10570	COG0277	FAD linked oxidase domain protein
HUT18_RS10575	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT18_RS10595	COG3654	unkown
HUT18_RS10620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT18_RS10645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT18_RS10665	COG1678	Uncharacterized ACR, COG1678
HUT18_RS10670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT18_RS10675	COG0776	regulation of translation
HUT18_RS10685	COG3973	AAA domain
HUT18_RS10705	COG2755	lipolytic protein G-D-S-L family
HUT18_RS10725	COG2223	nitrite transmembrane transporter activity
HUT18_RS10750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT18_RS10755	COG0793	Belongs to the peptidase S41A family
HUT18_RS10760	COG2177	Part of the ABC transporter FtsEX involved in
HUT18_RS10765	COG2884	Cell division ATP-binding protein ftsE
HUT18_RS10780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT18_RS10785	COG0515	serine threonine protein kinase
HUT18_RS10790	COG0515	serine threonine protein kinase
HUT18_RS10810	COG1175	transmembrane transport
HUT18_RS10815	COG0395	ABC-type sugar transport system, permease component
HUT18_RS10825	COG1764	response to oxidative stress
HUT18_RS10830	COG1846	Transcriptional regulator
HUT18_RS10855	COG1134	teichoic acid transport
HUT18_RS10860	COG2902	Dehydrogenase
HUT18_RS10880	COG0653	protein targeting
HUT18_RS10890	COG3214	Protein conserved in bacteria
HUT18_RS10895	COG2197	response regulator
HUT18_RS10900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUT18_RS10910	COG2272	Belongs to the type-B carboxylesterase lipase family
HUT18_RS10915	COG0823	Involved in the tonB-independent uptake of proteins
HUT18_RS10925	COG0745	RESPONSE REGULATOR receiver
HUT18_RS10930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUT18_RS10950	COG0714	Associated with various cellular activities
HUT18_RS10990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT18_RS11000	COG1482	cell wall glycoprotein biosynthetic process
HUT18_RS11010	COG2835	tetraacyldisaccharide 4'-kinase activity
HUT18_RS11015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT18_RS11055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT18_RS11060	COG0778	Nitroreductase
HUT18_RS11060	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUT18_RS11085	COG1316	TRANSCRIPTIONal
HUT18_RS11110	COG1316	TRANSCRIPTIONal
HUT18_RS11120	COG1316	TRANSCRIPTIONal
HUT18_RS11130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT18_RS11190	COG2205	protein histidine kinase activity
HUT18_RS11205	COG0745	RESPONSE REGULATOR receiver
HUT18_RS11210	COG3104	oligopeptide transport
HUT18_RS11220	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT18_RS11225	COG1191	sigma factor activity
HUT18_RS11230	COG1228	amidohydrolase
HUT18_RS11245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUT18_RS11250	COG0019	diaminopimelate decarboxylase activity
HUT18_RS11295	COG2755	lipolytic protein G-D-S-L family
HUT18_RS11300	COG0183	Belongs to the thiolase family
HUT18_RS11330	COG1595	DNA-templated transcription, initiation
HUT18_RS11360	COG2409	Drug exporters of the RND superfamily
HUT18_RS11370	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS11400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT18_RS11415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT18_RS11420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT18_RS11440	COG1396	sequence-specific DNA binding
HUT18_RS11450	COG4942	peptidase
HUT18_RS11595	COG0494	nUDIX hydrolase
HUT18_RS11980	COG0582	viral genome integration into host DNA
HUT18_RS11990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT18_RS12025	COG0148	phosphopyruvate hydratase activity
HUT18_RS12065	COG4585	Histidine kinase
HUT18_RS12070	COG3896	Chloramphenicol phosphotransferase-like protein
HUT18_RS12075	COG2130	NADP-dependent
HUT18_RS12080	COG0583	DNA-binding transcription factor activity
HUT18_RS12150	COG1136	(ABC) transporter
HUT18_RS12150	COG0577	efflux transmembrane transporter activity
HUT18_RS12155	COG1136	(ABC) transporter
HUT18_RS12160	COG0477	Major facilitator Superfamily
HUT18_RS12165	COG1316	TRANSCRIPTIONal
HUT18_RS12190	COG4585	Histidine kinase
HUT18_RS12205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT18_RS12210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT18_RS12215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUT18_RS12220	COG0193	aminoacyl-tRNA hydrolase activity
HUT18_RS12230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUT18_RS12240	COG1309	transcriptional regulator
HUT18_RS12250	COG4106	trans-aconitate 2-methyltransferase activity
HUT18_RS12255	COG1846	Transcriptional regulator
HUT18_RS12260	COG0702	epimerase
HUT18_RS12265	COG2272	Belongs to the type-B carboxylesterase lipase family
HUT18_RS12270	COG2197	response regulator
HUT18_RS12275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUT18_RS12310	COG2223	nitrite transmembrane transporter activity
HUT18_RS12315	COG2207	Transcriptional regulator
HUT18_RS12340	COG0488	(ABC) transporter
HUT18_RS12345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUT18_RS12350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT18_RS12355	COG3583	domain protein
HUT18_RS12355	COG3584	3D domain protein
HUT18_RS12360	COG0084	hydrolase, TatD family'
HUT18_RS12380	COG0697	spore germination
HUT18_RS12385	COG1846	Transcriptional regulator
HUT18_RS12415	COG2318	DinB family
HUT18_RS12420	COG1733	regulation of RNA biosynthetic process
HUT18_RS12425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT18_RS12430	COG2084	Dehydrogenase
HUT18_RS12435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT18_RS12455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT18_RS12490	COG2066	Belongs to the glutaminase family
HUT18_RS12505	COG1942	4-Oxalocrotonate Tautomerase
HUT18_RS12540	COG1714	RDD family
HUT18_RS12550	COG1122	ATPase activity
HUT18_RS12555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUT18_RS12560	COG0310	cobalt ion transport
HUT18_RS12575	COG2409	Drug exporters of the RND superfamily
HUT18_RS12585	COG4946	Tricorn protease homolog
HUT18_RS12585	COG0793	Belongs to the peptidase S41A family
HUT18_RS12595	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS12605	COG2072	flavoprotein involved in K transport
HUT18_RS12615	COG0708	Exodeoxyribonuclease III
HUT18_RS12625	COG4989	oxidoreductase activity
HUT18_RS12665	COG4257	antibiotic catabolic process
HUT18_RS12680	COG1309	transcriptional regulator
HUT18_RS12695	COG0583	DNA-binding transcription factor activity
HUT18_RS12735	COG0187	DNA topoisomerase II activity
HUT18_RS12750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS12755	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT18_RS12755	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUT18_RS12760	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT18_RS12770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT18_RS12775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT18_RS12800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT18_RS12810	COG1970	mechanosensitive ion channel activity
HUT18_RS12825	COG3191	aminopeptidase activity
HUT18_RS12830	COG1376	ErfK ybiS ycfS ynhG family protein
HUT18_RS12845	COG1247	-acetyltransferase
HUT18_RS12865	COG0386	Belongs to the glutathione peroxidase family
HUT18_RS12875	COG1686	Belongs to the peptidase S11 family
HUT18_RS12900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT18_RS12935	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT18_RS12935	COG0515	serine threonine protein kinase
HUT18_RS12945	COG1309	transcriptional regulator
HUT18_RS12950	COG0259	pyridoxamine-phosphate oxidase activity
HUT18_RS12955	COG2072	flavoprotein involved in K transport
HUT18_RS12960	COG0488	(ABC) transporter
HUT18_RS12990	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT18_RS13040	COG4821	SIS domain
HUT18_RS13050	COG2945	thiolester hydrolase activity
HUT18_RS13050	COG0596	Alpha beta hydrolase
HUT18_RS13055	COG0259	pyridoxamine-phosphate oxidase activity
HUT18_RS13070	COG1024	Enoyl-CoA hydratase
HUT18_RS13075	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS13090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT18_RS13110	COG0402	S-adenosylhomocysteine deaminase activity
HUT18_RS13170	COG0247	lactate metabolic process
HUT18_RS13170	COG0277	FAD linked oxidase domain protein
HUT18_RS13175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUT18_RS13210	COG0842	Transport permease protein
HUT18_RS13210	COG1716	ATPase activity
HUT18_RS13210	COG1131	(ABC) transporter
HUT18_RS13245	COG0667	Aldo Keto reductase
HUT18_RS13270	COG2252	PERMEase
HUT18_RS13280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT18_RS13315	COG2814	Major facilitator Superfamily
HUT18_RS13325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT18_RS13330	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT18_RS13340	COG1278	Cold shock
HUT18_RS13365	COG1131	(ABC) transporter
HUT18_RS13410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT18_RS13430	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT18_RS13435	COG3473	Maleate cis-trans isomerase
HUT18_RS13460	COG1061	Type III restriction enzyme res subunit
HUT18_RS13480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT18_RS13500	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT18_RS13510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT18_RS13515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT18_RS13530	COG1660	Displays ATPase and GTPase activities
HUT18_RS13535	COG2197	response regulator
HUT18_RS13550	COG0649	NAD binding
HUT18_RS13580	COG1174	glycine betaine transport
HUT18_RS13600	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUT18_RS13600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUT18_RS13610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUT18_RS13625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT18_RS13635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUT18_RS13655	COG0302	gtp cyclohydrolase
HUT18_RS13670	COG0037	tRNA processing
HUT18_RS13680	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT18_RS13685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT18_RS13695	COG0586	Pfam SNARE associated Golgi protein
HUT18_RS13700	COG0789	Transcriptional regulator
HUT18_RS13705	COG0076	glutamate decarboxylase activity
HUT18_RS13725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT18_RS13730	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS13760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT18_RS13765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT18_RS13770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT18_RS13775	COG0254	rRNA binding
HUT18_RS13785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT18_RS13840	COG3226	Transcriptional regulator
HUT18_RS13845	COG3511	phospholipase C
HUT18_RS13880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT18_RS13880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT18_RS13910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS13915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS13920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS13930	COG1126	abc transporter atp-binding protein
HUT18_RS13970	COG4974	Belongs to the 'phage' integrase family
HUT18_RS14015	COG2188	Transcriptional regulator
HUT18_RS14055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUT18_RS14060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT18_RS14065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUT18_RS14065	COG1754	DNA topoisomerase type I activity
HUT18_RS14070	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT18_RS14085	COG2172	sigma factor antagonist activity
HUT18_RS14090	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT18_RS14095	COG1111	helicase
HUT18_RS14095	COG1205	dead DEAH box helicase
HUT18_RS14150	COG0659	secondary active sulfate transmembrane transporter activity
HUT18_RS14155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT18_RS14160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT18_RS14170	COG2267	carboxylic ester hydrolase activity
HUT18_RS14195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT18_RS14220	COG0003	Pfam Anion-transporting ATPase
HUT18_RS14230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT18_RS14250	COG1408	metallophosphoesterase
HUT18_RS14260	COG1609	Transcriptional regulator
HUT18_RS14300	COG1674	ftsk spoiiie
HUT18_RS14390	COG2755	lipolytic protein G-D-S-L family
HUT18_RS14400	COG4209	transmembrane transport
HUT18_RS14405	COG0395	ABC-type sugar transport system, permease component
HUT18_RS14415	COG0673	inositol 2-dehydrogenase activity
HUT18_RS14475	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUT18_RS14500	COG1132	(ABC) transporter
HUT18_RS14505	COG1609	Transcriptional regulator
HUT18_RS14550	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS14555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT18_RS14565	COG0728	peptidoglycan biosynthetic process
HUT18_RS14575	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS14645	COG1595	DNA-templated transcription, initiation
HUT18_RS14660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT18_RS14675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUT18_RS14680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT18_RS14695	COG1802	Transcriptional regulator
HUT18_RS14705	COG0693	protein deglycase activity
HUT18_RS14735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT18_RS14750	COG1131	(ABC) transporter
HUT18_RS14755	COG3559	Exporter of polyketide antibiotics
HUT18_RS14770	COG3483	tryptophan 2,3-dioxygenase activity
HUT18_RS14780	COG0191	fructose-bisphosphate aldolase activity
HUT18_RS14785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUT18_RS14800	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUT18_RS14900	COG0477	Major facilitator Superfamily
HUT18_RS14915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT18_RS14925	COG0142	geranyltranstransferase activity
HUT18_RS14935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT18_RS14945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT18_RS14960	COG2124	cytochrome p450
HUT18_RS14980	COG0789	Transcriptional regulator
HUT18_RS14985	COG0484	heat shock protein binding
HUT18_RS14990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUT18_RS14995	COG0443	Heat shock 70 kDa protein
HUT18_RS15000	COG2181	nitrate reductase activity
HUT18_RS15000	COG0247	lactate metabolic process
HUT18_RS15075	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT18_RS15080	COG0717	Belongs to the dCTP deaminase family
HUT18_RS15115	COG5297	Belongs to the glycosyl hydrolase family 6
HUT18_RS15115	COG4733	cellulase activity
HUT18_RS15155	COG0395	ABC-type sugar transport system, permease component
HUT18_RS15160	COG1175	transmembrane transport
HUT18_RS15170	COG1940	carbohydrate kinase activity
HUT18_RS15185	COG1278	Cold shock
HUT18_RS15190	COG0513	Belongs to the DEAD box helicase family
HUT18_RS15220	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUT18_RS15245	COG1940	carbohydrate kinase activity
HUT18_RS15255	COG2267	carboxylic ester hydrolase activity
HUT18_RS15265	COG2072	flavoprotein involved in K transport
HUT18_RS15275	COG3973	AAA domain
HUT18_RS15285	COG1940	carbohydrate kinase activity
HUT18_RS15310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS15360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUT18_RS15370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUT18_RS15465	COG4977	sequence-specific DNA binding
HUT18_RS15540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT18_RS15545	COG1733	regulation of RNA biosynthetic process
HUT18_RS15565	COG3903	Transcriptional regulator
HUT18_RS15565	COG3629	intracellular signal transduction
HUT18_RS15570	COG1309	transcriptional regulator
HUT18_RS15585	COG1309	transcriptional regulator
HUT18_RS15590	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS15615	COG0675	Transposase, IS605 OrfB family
HUT18_RS15705	COG1404	Belongs to the peptidase S8 family
HUT18_RS15735	COG0395	ABC-type sugar transport system, permease component
HUT18_RS15740	COG1175	transmembrane transport
HUT18_RS15750	COG1609	Transcriptional regulator
HUT18_RS15760	COG0366	Alpha amylase catalytic
HUT18_RS15760	COG1470	cell adhesion involved in biofilm formation
HUT18_RS15790	COG2409	Drug exporters of the RND superfamily
HUT18_RS15810	COG5640	endopeptidase activity
HUT18_RS15815	COG1595	DNA-templated transcription, initiation
HUT18_RS15870	COG0747	negative chemotaxis
HUT18_RS15885	COG2755	lipolytic protein G-D-S-L family
HUT18_RS15895	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS15900	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS15910	COG0667	Aldo Keto reductase
HUT18_RS15915	COG4941	Belongs to the sigma-70 factor family
HUT18_RS15920	COG3795	YCII-related domain
HUT18_RS15945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT18_RS15950	COG1993	acr, cog1993
HUT18_RS15955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT18_RS15970	COG0251	oxidation-reduction process
HUT18_RS15990	COG0539	negative regulation of cytoplasmic translation
HUT18_RS16060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT18_RS16065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUT18_RS16075	COG0583	DNA-binding transcription factor activity
HUT18_RS16085	COG2304	oxidoreductase activity
HUT18_RS16090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT18_RS16105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUT18_RS16120	COG1741	Belongs to the pirin family
HUT18_RS16135	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS16140	COG1362	aminopeptidase activity
HUT18_RS16245	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT18_RS16250	COG0022	dehydrogenase e1 component
HUT18_RS16270	COG0515	serine threonine protein kinase
HUT18_RS16275	COG0515	serine threonine protein kinase
HUT18_RS16310	COG0746	molybdenum cofactor guanylyltransferase activity
HUT18_RS16340	COG1309	transcriptional regulator
HUT18_RS16345	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT18_RS16375	COG3396	Phenylacetate-CoA oxygenase
HUT18_RS16380	COG3460	Phenylacetate-CoA oxygenase
HUT18_RS16385	COG3396	Phenylacetate-CoA oxygenase
HUT18_RS16390	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT18_RS16395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT18_RS16420	COG4249	Peptidase C14 caspase catalytic subunit p20
HUT18_RS16420	COG2319	Wd-40 repeat
HUT18_RS16420	COG4249	Peptidase C14 caspase catalytic subunit p20
HUT18_RS16420	COG2319	Wd-40 repeat
HUT18_RS16440	COG0697	spore germination
HUT18_RS16455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT18_RS16465	COG2423	ornithine cyclodeaminase activity
HUT18_RS16480	COG1716	ATPase activity
HUT18_RS16485	COG1716	ATPase activity
HUT18_RS16500	COG0768	penicillin binding
HUT18_RS16505	COG0515	serine threonine protein kinase
HUT18_RS16510	COG3764	Sortase (surface protein transpeptidase)
HUT18_RS16515	COG3764	Sortase (surface protein transpeptidase)
HUT18_RS16540	COG0705	Rhomboid family
HUT18_RS16540	COG0457	Tetratricopeptide repeat
HUT18_RS16570	COG1595	DNA-templated transcription, initiation
HUT18_RS16605	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS16640	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS16655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT18_RS16670	COG0515	serine threonine protein kinase
HUT18_RS16695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT18_RS16710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUT18_RS16715	COG1518	maintenance of DNA repeat elements
HUT18_RS16730	COG1857	crispr-associated protein
HUT18_RS16760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT18_RS16765	COG0187	DNA topoisomerase II activity
HUT18_RS16770	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUT18_RS16775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT18_RS16780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT18_RS16785	COG0592	DNA-directed DNA polymerase activity
HUT18_RS16790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUT18_RS16795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUT18_RS16800	COG0594	ribonuclease P activity
HUT18_RS16805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT18_RS16810	COG0706	membrane insertase activity
HUT18_RS16820	COG0357	Ribosomal RNA small subunit methyltransferase G
HUT18_RS16825	COG1192	Involved in chromosome partitioning
HUT18_RS16840	COG3118	belongs to the thioredoxin family
HUT18_RS16845	COG0492	ferredoxin-NADP+ reductase activity
HUT18_RS16855	COG1595	DNA-templated transcription, initiation
HUT18_RS16860	COG0515	serine threonine protein kinase
HUT18_RS16860	COG2815	serine threonine protein kinase
HUT18_RS16875	COG0617	tRNA 3'-terminal CCA addition
HUT18_RS16890	COG1260	myo-inositol-1-phosphate synthase
HUT18_RS16900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT18_RS16925	COG0360	Binds together with S18 to 16S ribosomal RNA
HUT18_RS16930	COG0629	single-stranded DNA binding
HUT18_RS16935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT18_RS16940	COG0359	binds to the 23S rRNA
HUT18_RS16945	COG0534	Mate efflux family protein
HUT18_RS16970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT18_RS16980	COG4977	sequence-specific DNA binding
HUT18_RS16985	COG1309	transcriptional regulator
HUT18_RS16990	COG0596	Alpha beta hydrolase
HUT18_RS17005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT18_RS17015	COG0583	DNA-binding transcription factor activity
HUT18_RS17025	COG0393	Putative heavy-metal-binding
HUT18_RS17035	COG2318	DinB family
HUT18_RS17040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT18_RS17055	COG2814	Major facilitator Superfamily
HUT18_RS17075	COG0626	cystathionine gamma-synthase activity
HUT18_RS17080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT18_RS17085	COG1950	PFAM Membrane protein of
HUT18_RS17090	COG0662	Cupin 2, conserved barrel domain protein
HUT18_RS17115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUT18_RS17135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT18_RS17140	COG1609	Transcriptional regulator
HUT18_RS17145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT18_RS17150	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS17155	COG1271	oxidase subunit
HUT18_RS17160	COG1294	oxidase, subunit
HUT18_RS17165	COG4988	ABC transporter
HUT18_RS17195	COG2226	methyltransferase
HUT18_RS17200	COG2226	methyltransferase
HUT18_RS17215	COG0561	phosphatase activity
HUT18_RS17245	COG2815	serine threonine protein kinase
HUT18_RS17245	COG0515	serine threonine protein kinase
HUT18_RS17270	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUT18_RS17305	COG1309	transcriptional regulator
HUT18_RS17310	COG0596	Alpha beta hydrolase
HUT18_RS17315	COG0561	phosphatase activity
HUT18_RS17320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT18_RS17325	COG0077	Prephenate dehydratase
HUT18_RS17330	COG2837	iron assimilation
HUT18_RS17345	COG1999	signal sequence binding
HUT18_RS17365	COG1672	PFAM Archaeal ATPase
HUT18_RS17365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT18_RS17395	COG1607	acyl-coa hydrolase
HUT18_RS17415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT18_RS17425	COG0640	Transcriptional regulator
HUT18_RS17435	COG1278	Cold shock
HUT18_RS17440	COG0006	proline dipeptidase activity
HUT18_RS17455	COG0653	protein targeting
HUT18_RS17470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT18_RS17495	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUT18_RS17515	COG1595	DNA-templated transcription, initiation
HUT18_RS17520	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS17530	COG0745	RESPONSE REGULATOR receiver
HUT18_RS17580	COG0745	RESPONSE REGULATOR receiver
HUT18_RS17600	COG2318	DinB family
HUT18_RS17605	COG2353	YceI-like domain
HUT18_RS17610	COG0477	Major facilitator Superfamily
HUT18_RS17615	COG1846	Transcriptional regulator
HUT18_RS17630	COG2197	response regulator
HUT18_RS17635	COG4585	Histidine kinase
HUT18_RS17640	COG1191	sigma factor activity
HUT18_RS17690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUT18_RS17735	COG0577	efflux transmembrane transporter activity
HUT18_RS17735	COG1136	(ABC) transporter
HUT18_RS17775	COG2116	formate transmembrane transporter activity
HUT18_RS17880	COG0151	Belongs to the GarS family
HUT18_RS17895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUT18_RS17915	COG2197	response regulator
HUT18_RS17930	COG1131	(ABC) transporter
HUT18_RS17950	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT18_RS17955	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT18_RS17960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT18_RS18000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT18_RS18030	COG1643	Atp-dependent helicase
HUT18_RS18070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT18_RS18090	COG0513	Belongs to the DEAD box helicase family
HUT18_RS18120	COG1215	transferase activity, transferring glycosyl groups
HUT18_RS18130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS18140	COG2226	methyltransferase
HUT18_RS18145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT18_RS18150	COG1454	alcohol dehydrogenase
HUT18_RS18180	COG0515	serine threonine protein kinase
HUT18_RS18220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT18_RS18445	COG3723	Recombinational DNA repair protein, rece pathway
HUT18_RS18450	COG5377	YqaJ viral recombinase family
HUT18_RS18470	COG4585	Histidine kinase
HUT18_RS18475	COG2197	response regulator
HUT18_RS18485	COG2409	Drug exporters of the RND superfamily
HUT18_RS18545	COG1122	ATPase activity
HUT18_RS18560	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS18565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT18_RS18570	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS18630	COG2329	Antibiotic biosynthesis monooxygenase
HUT18_RS18670	COG3425	synthase
HUT18_RS18675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUT18_RS18695	COG1720	tRNA m6t6A37 methyltransferase activity
HUT18_RS18725	COG4941	Belongs to the sigma-70 factor family
HUT18_RS18755	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HUT18_RS18770	COG1196	nuclear chromosome segregation
HUT18_RS18770	COG0739	heme binding
HUT18_RS18770	COG0741	lytic transglycosylase activity
HUT18_RS18790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUT18_RS18795	COG0579	oxidoreductase
HUT18_RS18835	COG0596	Alpha beta hydrolase
HUT18_RS18840	COG1470	cell adhesion involved in biofilm formation
HUT18_RS18840	COG0366	Alpha amylase catalytic
HUT18_RS18850	COG1252	NADH dehydrogenase
HUT18_RS18895	COG1316	TRANSCRIPTIONal
HUT18_RS18965	COG1196	nuclear chromosome segregation
HUT18_RS18965	COG0741	lytic transglycosylase activity
HUT18_RS18965	COG0739	heme binding
HUT18_RS18970	COG0671	phosphoesterase, PA-phosphatase related
HUT18_RS18975	COG0277	FAD linked oxidase domain protein
HUT18_RS18995	COG1937	Protein conserved in bacteria
HUT18_RS19005	COG0306	phosphate transporter
HUT18_RS19040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUT18_RS19050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUT18_RS19055	COG1725	Transcriptional regulator
HUT18_RS19065	COG0456	acetyltransferase
HUT18_RS19075	COG0737	Belongs to the 5'-nucleotidase family
HUT18_RS19095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT18_RS19105	COG1609	Transcriptional regulator
HUT18_RS19110	COG0745	RESPONSE REGULATOR receiver
HUT18_RS19135	COG2897	thiosulfate sulfurtransferase activity
HUT18_RS19155	COG3485	protocatechuate 3,4-dioxygenase
HUT18_RS19195	COG0515	serine threonine protein kinase
HUT18_RS19195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT18_RS19200	COG1490	D-aminoacyl-tRNA deacylase activity
HUT18_RS19220	COG4552	Acetyltransferase involved in intracellular survival and related
HUT18_RS19225	COG0673	inositol 2-dehydrogenase activity
HUT18_RS19235	COG1309	transcriptional regulator
HUT18_RS19245	COG2146	nitrite reductase [NAD(P)H] activity
HUT18_RS19245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT18_RS19255	COG0243	molybdopterin cofactor binding
HUT18_RS19260	COG0247	lactate metabolic process
HUT18_RS19260	COG2181	nitrate reductase activity
HUT18_RS19270	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT18_RS19275	COG3396	Phenylacetate-CoA oxygenase
HUT18_RS19285	COG3396	Phenylacetate-CoA oxygenase
HUT18_RS19290	COG2409	Drug exporters of the RND superfamily
HUT18_RS19340	COG1595	DNA-templated transcription, initiation
HUT18_RS19365	COG4977	sequence-specific DNA binding
HUT18_RS19385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT18_RS19410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS19425	COG1595	DNA-templated transcription, initiation
HUT18_RS19440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT18_RS19445	COG0583	DNA-binding transcription factor activity
HUT18_RS19465	COG2084	Dehydrogenase
HUT18_RS19470	COG1733	regulation of RNA biosynthetic process
HUT18_RS19490	COG1090	epimerase
HUT18_RS19495	COG1595	DNA-templated transcription, initiation
HUT18_RS19500	COG1595	DNA-templated transcription, initiation
HUT18_RS19505	COG2318	DinB family
HUT18_RS19520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT18_RS19565	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS19575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT18_RS19585	COG0583	DNA-binding transcription factor activity
HUT18_RS19600	COG0588	phosphoglycerate mutase activity
HUT18_RS19620	COG5002	protein histidine kinase activity
HUT18_RS19635	COG1329	Transcriptional regulator
HUT18_RS19640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUT18_RS19645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUT18_RS19655	COG0215	cysteine-tRNA ligase activity
HUT18_RS19660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT18_RS19670	COG4585	Histidine kinase
HUT18_RS19675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT18_RS19685	COG3842	ATPase activity
HUT18_RS19700	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS19715	COG3424	synthase
HUT18_RS19725	COG2124	cytochrome p450
HUT18_RS19805	COG1105	Belongs to the carbohydrate kinase PfkB family
HUT18_RS19810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUT18_RS19835	COG1595	DNA-templated transcription, initiation
HUT18_RS19840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT18_RS19855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT18_RS19860	COG0463	Glycosyl transferase, family 2
HUT18_RS19875	COG1278	Cold shock
HUT18_RS19880	COG0459	protein refolding
HUT18_RS19895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUT18_RS19900	COG1737	Transcriptional regulator
HUT18_RS19940	COG3973	AAA domain
HUT18_RS19950	COG0739	heme binding
HUT18_RS20015	COG2205	protein histidine kinase activity
HUT18_RS20020	COG0745	RESPONSE REGULATOR receiver
HUT18_RS20035	COG1194	a g-specific adenine glycosylase
HUT18_RS20055	COG2319	Wd-40 repeat
HUT18_RS20065	COG0667	Aldo Keto reductase
HUT18_RS20075	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUT18_RS20095	COG0248	Ppx GppA phosphatase
HUT18_RS20100	COG1082	Xylose isomerase domain protein TIM barrel
HUT18_RS20115	COG0129	dihydroxy-acid dehydratase activity
HUT18_RS20125	COG4991	sh3 domain protein
HUT18_RS20130	COG1129	ABC transporter
HUT18_RS20130	COG0842	Transport permease protein
HUT18_RS20140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUT18_RS20160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT18_RS20165	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUT18_RS20200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT18_RS20230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUT18_RS20235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUT18_RS20240	COG0181	hydroxymethylbilane synthase activity
HUT18_RS20245	COG1648	precorrin-2 dehydrogenase activity
HUT18_RS20245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT18_RS20250	COG0113	porphobilinogen synthase activity
HUT18_RS20255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT18_RS20255	COG0515	serine threonine protein kinase
HUT18_RS20275	COG2205	protein histidine kinase activity
HUT18_RS20280	COG0745	RESPONSE REGULATOR receiver
HUT18_RS20300	COG3655	Transcriptional regulator
HUT18_RS20370	COG0667	Aldo Keto reductase
HUT18_RS20405	COG2318	DinB family
HUT18_RS20430	COG1690	Belongs to the RtcB family
HUT18_RS20455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUT18_RS20460	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUT18_RS20465	COG0018	arginyl-trna synthetase
HUT18_RS20480	COG1742	UPF0060 membrane protein
HUT18_RS20570	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS20600	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS20610	COG0300	oxidoreductase activity
HUT18_RS20615	COG2072	flavoprotein involved in K transport
HUT18_RS20625	COG1309	transcriptional regulator
HUT18_RS20635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT18_RS20640	COG0406	alpha-ribazole phosphatase activity
HUT18_RS20650	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT18_RS20650	COG1902	pentaerythritol trinitrate reductase activity
HUT18_RS20655	COG0515	serine threonine protein kinase
HUT18_RS20655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT18_RS20680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT18_RS20690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT18_RS20700	COG1333	cytochrome c biogenesis protein
HUT18_RS20705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUT18_RS20785	COG0697	spore germination
HUT18_RS20800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUT18_RS20805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUT18_RS20810	COG0726	polysaccharide deacetylase
HUT18_RS20815	COG0163	prenyltransferase activity
HUT18_RS20830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT18_RS20845	COG1309	transcriptional regulator
HUT18_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS20870	COG0183	Belongs to the thiolase family
HUT18_RS20885	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT18_RS20905	COG0494	nUDIX hydrolase
HUT18_RS20975	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HUT18_RS21015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT18_RS21025	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS21050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT18_RS21060	COG2226	methyltransferase
HUT18_RS21085	COG0791	NLP P60 protein
HUT18_RS21085	COG1388	LysM domain
HUT18_RS21085	COG3103	Sh3 type 3 domain protein
HUT18_RS21100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT18_RS21105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT18_RS21110	COG0649	NAD binding
HUT18_RS21120	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUT18_RS21125	COG1034	ATP synthesis coupled electron transport
HUT18_RS21130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT18_RS21135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT18_RS21140	COG0839	Belongs to the complex I subunit 6 family
HUT18_RS21145	COG0713	ATP synthesis coupled electron transport
HUT18_RS21150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT18_RS21160	COG1007	ATP synthesis coupled electron transport
HUT18_RS21170	COG0514	ATP-dependent DNA helicase (RecQ)
HUT18_RS21210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT18_RS21225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUT18_RS21235	COG2188	Transcriptional regulator
HUT18_RS21240	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS21255	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT18_RS21270	COG3209	COG3209 Rhs family protein
HUT18_RS21315	COG0561	phosphatase activity
HUT18_RS21380	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT18_RS21385	COG2234	aminopeptidase activity
HUT18_RS21385	COG4935	Belongs to the peptidase S8 family
HUT18_RS21390	COG0702	epimerase
HUT18_RS21405	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT18_RS21410	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT18_RS21410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT18_RS21420	COG4585	Histidine kinase
HUT18_RS21430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT18_RS21435	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT18_RS21440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT18_RS21445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT18_RS21455	COG0839	Belongs to the complex I subunit 6 family
HUT18_RS21460	COG0713	ATP synthesis coupled electron transport
HUT18_RS21465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT18_RS21475	COG1007	ATP synthesis coupled electron transport
HUT18_RS21480	COG0501	Belongs to the peptidase M48B family
HUT18_RS21485	COG3304	Inner membrane component domain
HUT18_RS21495	COG1666	GTP binding
HUT18_RS21535	COG0702	epimerase
HUT18_RS21555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT18_RS21560	COG2030	dehydratase
HUT18_RS21580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUT18_RS21585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT18_RS21595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT18_RS21600	COG0436	Aminotransferase
HUT18_RS21610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT18_RS21615	COG0250	Participates in transcription elongation, termination and antitermination
HUT18_RS21625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUT18_RS21630	COG0081	regulation of translation
HUT18_RS21645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUT18_RS21650	COG0222	ribosome binding
HUT18_RS21655	COG0085	RNA polymerase activity
HUT18_RS21660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUT18_RS21720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUT18_RS21725	COG0049	tRNA binding
HUT18_RS21730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT18_RS21735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT18_RS21745	COG0051	transcription antitermination factor activity, RNA binding
HUT18_RS21750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUT18_RS21755	COG0088	Forms part of the polypeptide exit tunnel
HUT18_RS21760	COG0089	rRNA binding
HUT18_RS21765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUT18_RS21770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUT18_RS21775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUT18_RS21780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUT18_RS21785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUT18_RS21790	COG0255	Belongs to the universal ribosomal protein uL29 family
HUT18_RS21795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUT18_RS21800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUT18_RS21805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUT18_RS21810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUT18_RS21815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT18_RS21820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUT18_RS21825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUT18_RS21830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUT18_RS21835	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUT18_RS21845	COG0200	Binds to the 23S rRNA
HUT18_RS21855	COG0563	adenylate kinase activity
HUT18_RS21865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUT18_RS21870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT18_RS21875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUT18_RS21880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUT18_RS21890	COG0203	ribosomal protein L17
HUT18_RS21895	COG0101	tRNA pseudouridine synthase activity
HUT18_RS21905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUT18_RS21910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUT18_RS21915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT18_RS21930	COG1072	(Pantothenic acid kinase))
HUT18_RS21935	COG0736	holo-[acyl-carrier-protein] synthase activity
HUT18_RS21940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUT18_RS21940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUT18_RS21945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT18_RS21955	COG0802	atpase or kinase
HUT18_RS21970	COG1214	PFAM Peptidase M22, glycoprotease
HUT18_RS21970	COG0456	acetyltransferase
HUT18_RS21980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT18_RS22015	COG0726	polysaccharide deacetylase
HUT18_RS22020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT18_RS22025	COG0459	protein refolding
HUT18_RS22030	COG3345	alpha-galactosidase
HUT18_RS22035	COG4221	oxidoreductase activity
HUT18_RS22045	COG0583	DNA-binding transcription factor activity
HUT18_RS22055	COG2197	response regulator
HUT18_RS22060	COG1595	DNA-templated transcription, initiation
HUT18_RS22070	COG0516	GMP reductase activity
HUT18_RS22085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT18_RS22110	COG0515	serine threonine protein kinase
HUT18_RS22120	COG2815	serine threonine protein kinase
HUT18_RS22120	COG0515	serine threonine protein kinase
HUT18_RS22125	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS22145	COG2211	Major facilitator Superfamily
HUT18_RS22150	COG2723	6-phospho-beta-galactosidase activity
HUT18_RS22160	COG0519	Catalyzes the synthesis of GMP from XMP
HUT18_RS22160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT18_RS22195	COG1175	transmembrane transport
HUT18_RS22200	COG0395	ABC-type sugar transport system, permease component
HUT18_RS22240	COG2197	response regulator
HUT18_RS22270	COG0739	heme binding
HUT18_RS22280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS22280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS22295	COG0714	Associated with various cellular activities
HUT18_RS22305	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUT18_RS22420	COG1222	aaa ATPase
HUT18_RS22450	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT18_RS22480	COG0138	bifunctional purine biosynthesis protein purh
HUT18_RS22490	COG1714	RDD family
HUT18_RS22495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT18_RS22505	COG2353	YceI-like domain
HUT18_RS22525	COG1695	Transcriptional regulator
HUT18_RS22535	COG0039	L-malate dehydrogenase activity
HUT18_RS22570	COG3119	arylsulfatase activity
HUT18_RS22575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT18_RS22585	COG1476	TRANSCRIPTIONal
HUT18_RS22605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT18_RS22610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT18_RS22615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT18_RS22625	COG0180	Tryptophanyl-tRNA synthetase
HUT18_RS22650	COG1295	ribonuclease BN
HUT18_RS22660	COG1408	metallophosphoesterase
HUT18_RS22670	COG2409	Drug exporters of the RND superfamily
HUT18_RS22710	COG1053	succinate dehydrogenase
HUT18_RS22720	COG2009	succinate dehydrogenase
HUT18_RS22730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUT18_RS22760	COG1595	DNA-templated transcription, initiation
HUT18_RS22775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS22775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS22795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT18_RS22805	COG1216	Glycosyl transferase, family 2
HUT18_RS22820	COG2089	acid synthase
HUT18_RS22830	COG1473	amidohydrolase
HUT18_RS22830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT18_RS22885	COG1946	Acyl-CoA thioesterase
HUT18_RS22890	COG4585	Histidine kinase
HUT18_RS22895	COG2197	response regulator
HUT18_RS22945	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT18_RS22955	COG0456	acetyltransferase
HUT18_RS22955	COG1846	Transcriptional regulator
HUT18_RS22960	COG1609	Transcriptional regulator
HUT18_RS22965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUT18_RS22995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT18_RS23000	COG3962	Belongs to the TPP enzyme family
HUT18_RS23015	COG2205	protein histidine kinase activity
HUT18_RS23020	COG0745	RESPONSE REGULATOR receiver
HUT18_RS23035	COG0740	serine-type endopeptidase activity
HUT18_RS23040	COG0740	serine-type endopeptidase activity
HUT18_RS23065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT18_RS23090	COG2255	four-way junction helicase activity
HUT18_RS23095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT18_RS23110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT18_RS23120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT18_RS23145	COG3550	peptidyl-serine autophosphorylation
HUT18_RS23150	COG2186	Transcriptional regulator
HUT18_RS23160	COG1129	ABC transporter
HUT18_RS23165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT18_RS23180	COG0515	serine threonine protein kinase
HUT18_RS23200	COG1331	Highly conserved protein containing a thioredoxin domain
HUT18_RS23220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUT18_RS23285	COG0515	serine threonine protein kinase
HUT18_RS23285	COG2815	serine threonine protein kinase
HUT18_RS23300	COG2894	cell division
HUT18_RS23340	COG2885	chlorophyll binding
HUT18_RS23365	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT18_RS23385	COG2318	DinB family
HUT18_RS23395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT18_RS23400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUT18_RS23415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT18_RS23420	COG0450	alkyl hydroperoxide reductase
HUT18_RS23440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT18_RS23455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT18_RS23465	COG0114	fumarate hydratase activity
HUT18_RS23495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT18_RS23495	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT18_RS23520	COG0778	Nitroreductase
HUT18_RS23525	COG1722	exodeoxyribonuclease VII activity
HUT18_RS23530	COG1570	exodeoxyribonuclease VII activity
HUT18_RS23535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT18_RS23555	COG3903	Transcriptional regulator
HUT18_RS23555	COG3629	intracellular signal transduction
HUT18_RS23560	COG0012	GTP binding
HUT18_RS23635	COG1733	regulation of RNA biosynthetic process
HUT18_RS23710	COG1946	Acyl-CoA thioesterase
HUT18_RS23765	COG1280	lysine exporter protein (LysE YggA)
HUT18_RS23785	COG4166	transmembrane transport
HUT18_RS23795	COG0444	Belongs to the ABC transporter superfamily
HUT18_RS23800	COG4608	Belongs to the ABC transporter superfamily
HUT18_RS23810	COG3340	Belongs to the peptidase S51 family
HUT18_RS23820	COG0601	transmembrane transport
HUT18_RS23825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT18_RS23830	COG0444	Belongs to the ABC transporter superfamily
HUT18_RS23835	COG4608	Belongs to the ABC transporter superfamily
HUT18_RS23850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT18_RS23895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT18_RS23900	COG1611	Belongs to the LOG family
HUT18_RS23905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT18_RS23915	COG0519	Catalyzes the synthesis of GMP from XMP
HUT18_RS23920	COG1024	Enoyl-CoA hydratase
HUT18_RS23935	COG1595	DNA-templated transcription, initiation
HUT18_RS23945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT18_RS23950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT18_RS23985	COG0598	Magnesium transport protein CorA
HUT18_RS23990	COG2409	Drug exporters of the RND superfamily
HUT18_RS24015	COG0613	PHP domain protein
HUT18_RS24020	COG2095	MarC family integral membrane protein
HUT18_RS24030	COG1432	Conserved Protein
HUT18_RS24085	COG0747	negative chemotaxis
HUT18_RS24155	COG0210	DNA helicase
HUT18_RS24160	COG0494	nUDIX hydrolase
HUT18_RS24225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT18_RS24290	COG1615	UPF0182 protein
HUT18_RS24315	COG0735	belongs to the Fur family
HUT18_RS24325	COG0483	inositol monophosphate 1-phosphatase activity
HUT18_RS24335	COG2076	Multidrug Resistance protein
HUT18_RS24340	COG1162	GTPase activity
HUT18_RS24345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT18_RS24350	COG2135	peptidase activity
HUT18_RS24365	COG1595	DNA-templated transcription, initiation
HUT18_RS24370	COG5662	AntiSigma factor
HUT18_RS24390	COG0789	Transcriptional regulator
HUT18_RS24400	COG1063	alcohol dehydrogenase
HUT18_RS24410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUT18_RS24415	COG2409	Drug exporters of the RND superfamily
HUT18_RS24420	COG4106	trans-aconitate 2-methyltransferase activity
HUT18_RS24440	COG3321	synthase
HUT18_RS24440	COG0604	alcohol dehydrogenase
HUT18_RS24460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT18_RS24465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS24470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT18_RS24495	COG0326	Molecular chaperone. Has ATPase activity
HUT18_RS24550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HUT18_RS24595	COG0328	RNA-DNA hybrid ribonuclease activity
HUT18_RS24615	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT18_RS24620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT18_RS24620	COG0723	plastoquinol--plastocyanin reductase activity
HUT18_RS24640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT18_RS24645	COG1793	dna ligase
HUT18_RS24645	COG3285	dna ligase
HUT18_RS24655	COG0640	Transcriptional regulator
HUT18_RS24670	COG0772	Belongs to the SEDS family
HUT18_RS24750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT18_RS24765	COG0745	RESPONSE REGULATOR receiver
HUT18_RS24770	COG2205	protein histidine kinase activity
HUT18_RS24775	COG0567	Dehydrogenase, E1 component
HUT18_RS24775	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT18_RS24825	COG2755	lipolytic protein G-D-S-L family
HUT18_RS24850	COG0604	alcohol dehydrogenase
HUT18_RS24855	COG0281	malic enzyme
HUT18_RS24865	COG0765	amino acid transport
HUT18_RS24870	COG1126	abc transporter atp-binding protein
HUT18_RS24875	COG4106	trans-aconitate 2-methyltransferase activity
HUT18_RS24920	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS24935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT18_RS24935	COG0456	acetyltransferase
HUT18_RS24945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT18_RS24980	COG1597	lipid kinase activity
HUT18_RS24995	COG0363	glucosamine-6-phosphate deaminase activity
HUT18_RS25000	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT18_RS25005	COG2188	Transcriptional regulator
HUT18_RS25025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT18_RS25030	COG2124	cytochrome p450
HUT18_RS25040	COG0242	peptide deformylase activity
HUT18_RS25065	COG3344	reverse transcriptase
HUT18_RS25115	COG0745	RESPONSE REGULATOR receiver
HUT18_RS25120	COG0018	arginyl-trna synthetase
HUT18_RS25125	COG0019	diaminopimelate decarboxylase activity
HUT18_RS25130	COG0460	homoserine dehydrogenase
HUT18_RS25135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT18_RS25140	COG0083	homoserine kinase activity
HUT18_RS25160	COG2207	Transcriptional regulator
HUT18_RS25165	COG2207	Transcriptional regulator
HUT18_RS25175	COG0254	rRNA binding
HUT18_RS25180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUT18_RS25185	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT18_RS25195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT18_RS25200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT18_RS25220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT18_RS25225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUT18_RS25230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT18_RS25235	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUT18_RS25240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUT18_RS25245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUT18_RS25250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUT18_RS25270	COG2197	response regulator
HUT18_RS25275	COG4585	Histidine kinase
HUT18_RS25290	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT18_RS25320	COG3345	alpha-galactosidase
HUT18_RS25325	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUT18_RS25365	COG1131	(ABC) transporter
HUT18_RS25390	COG0183	Belongs to the thiolase family
HUT18_RS25420	COG0745	RESPONSE REGULATOR receiver
HUT18_RS25440	COG3345	alpha-galactosidase
HUT18_RS25520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS25520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS25555	COG2267	carboxylic ester hydrolase activity
HUT18_RS25570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUT18_RS25575	COG0857	belongs to the CobB CobQ family
HUT18_RS25575	COG0280	phosphate acetyltransferase
HUT18_RS25580	COG0205	6-phosphofructokinase activity
HUT18_RS25640	COG3833	ABC-type maltose transport systems, permease component
HUT18_RS25645	COG1175	transmembrane transport
HUT18_RS25655	COG4565	transcriptional regulatory protein
HUT18_RS25660	COG3290	protein histidine kinase activity
HUT18_RS25665	COG1301	dicarboxylic acid transport
HUT18_RS25700	COG0366	Alpha amylase catalytic
HUT18_RS25705	COG0058	SHG alpha-glucan phosphorylase activity
HUT18_RS25735	COG1132	(ABC) transporter
HUT18_RS25740	COG1132	(ABC) transporter
HUT18_RS25785	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT18_RS25800	COG0006	proline dipeptidase activity
HUT18_RS25805	COG1802	Transcriptional regulator
HUT18_RS25840	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS25845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT18_RS25845	COG3320	Male sterility
HUT18_RS25850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT18_RS25860	COG0477	Major facilitator Superfamily
HUT18_RS25935	COG0464	growth
HUT18_RS25945	COG2197	response regulator
HUT18_RS25970	COG1760	l-serine dehydratase
HUT18_RS25975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT18_RS25980	COG0509	glycine decarboxylation via glycine cleavage system
HUT18_RS25985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT18_RS26005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT18_RS26020	COG0444	Belongs to the ABC transporter superfamily
HUT18_RS26025	COG4608	Belongs to the ABC transporter superfamily
HUT18_RS26030	COG2860	membrane
HUT18_RS26040	COG2378	regulation of single-species biofilm formation
HUT18_RS26085	COG0482	sulfurtransferase activity
HUT18_RS26100	COG0110	maltose O-acetyltransferase activity
HUT18_RS26105	COG1611	Belongs to the LOG family
HUT18_RS26110	COG4221	oxidoreductase activity
HUT18_RS26120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT18_RS26130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT18_RS26135	COG0154	amidase activity
HUT18_RS26145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT18_RS26155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT18_RS26185	COG2362	D-Aminopeptidase
HUT18_RS26190	COG1196	nuclear chromosome segregation
HUT18_RS26205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT18_RS26215	COG2409	Drug exporters of the RND superfamily
HUT18_RS26240	COG2197	response regulator
HUT18_RS26255	COG0667	Aldo Keto reductase
HUT18_RS26275	COG0440	acetolactate synthase activity
HUT18_RS26280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT18_RS26285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT18_RS26300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUT18_RS26320	COG0506	proline dehydrogenase activity
HUT18_RS26325	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS26335	COG2856	Zn peptidase
HUT18_RS26355	COG0473	3-isopropylmalate dehydrogenase activity
HUT18_RS26360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT18_RS26365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT18_RS26380	COG2353	YceI-like domain
HUT18_RS26390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT18_RS26435	COG2018	Roadblock/LC7 domain
HUT18_RS26455	COG2018	Roadblock/LC7 domain
HUT18_RS26470	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT18_RS26475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUT18_RS26525	COG1414	Transcriptional regulator
HUT18_RS26530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT18_RS26535	COG0066	3-isopropylmalate dehydratase activity
HUT18_RS26545	COG0776	regulation of translation
HUT18_RS26555	COG1920	GTP binding
HUT18_RS26565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT18_RS26570	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT18_RS26590	COG0351	phosphomethylpyrimidine kinase
HUT18_RS26595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT18_RS26600	COG1461	Dihydroxyacetone kinase
HUT18_RS26615	COG0326	Molecular chaperone. Has ATPase activity
HUT18_RS26620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUT18_RS26625	COG0742	ribosomal rna small subunit methyltransferase
HUT18_RS26630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUT18_RS26645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUT18_RS26650	COG0571	ribonuclease III activity
HUT18_RS26655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT18_RS26665	COG2340	Cysteine-rich secretory protein family
HUT18_RS26670	COG1254	Belongs to the acylphosphatase family
HUT18_RS26680	COG1196	nuclear chromosome segregation
HUT18_RS26685	COG0477	Major facilitator Superfamily
HUT18_RS26715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT18_RS26730	COG0228	four-way junction DNA binding
HUT18_RS26735	COG1837	Belongs to the UPF0109 family
HUT18_RS26740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUT18_RS26745	COG0336	Belongs to the RNA methyltransferase TrmD family
HUT18_RS26750	COG0335	large ribosomal subunit rRNA binding
HUT18_RS26760	COG0681	Belongs to the peptidase S26 family
HUT18_RS26770	COG0681	Belongs to the peptidase S26 family
HUT18_RS26775	COG1051	belongs to the nudix hydrolase family
HUT18_RS26785	COG0792	nuclease activity
HUT18_RS26800	COG1191	sigma factor activity
HUT18_RS26815	COG0052	Belongs to the universal ribosomal protein uS2 family
HUT18_RS26820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUT18_RS26825	COG0528	UMP kinase activity
HUT18_RS26830	COG0233	cytoplasmic translational termination
HUT18_RS26840	COG1278	Cold shock
HUT18_RS26845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUT18_RS26860	COG3842	ATPase activity
HUT18_RS26885	COG1136	(ABC) transporter
HUT18_RS26885	COG0577	efflux transmembrane transporter activity
HUT18_RS26890	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS26900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT18_RS26940	COG2508	Transcriptional regulator
HUT18_RS26945	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS26960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUT18_RS26965	COG0750	zinc metalloprotease
HUT18_RS26970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT18_RS26985	COG0442	prolyl-tRNA aminoacylation
HUT18_RS27005	COG0779	Required for maturation of 30S ribosomal subunits
HUT18_RS27020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUT18_RS27030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUT18_RS27035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUT18_RS27050	COG4608	Belongs to the ABC transporter superfamily
HUT18_RS27060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT18_RS27065	COG0601	transmembrane transport
HUT18_RS27070	COG0747	negative chemotaxis
HUT18_RS27075	COG0455	bacterial-type flagellum organization
HUT18_RS27090	COG3266	domain, Protein
HUT18_RS27105	COG1404	Belongs to the peptidase S8 family
HUT18_RS27150	COG1674	ftsk spoiiie
HUT18_RS27165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUT18_RS27170	COG1185	polyribonucleotide nucleotidyltransferase activity
HUT18_RS27175	COG0612	Peptidase, M16
HUT18_RS27180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT18_RS27195	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUT18_RS27200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT18_RS27205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT18_RS27235	COG2770	Histidine kinase
HUT18_RS27235	COG2208	phosphoserine phosphatase activity
HUT18_RS27240	COG3850	Histidine kinase
HUT18_RS27240	COG4999	Histidine kinase
HUT18_RS27240	COG3437	response regulator, receiver
HUT18_RS27240	COG2205	protein histidine kinase activity
HUT18_RS27250	COG1674	ftsk spoiiie
HUT18_RS27260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT18_RS27270	COG1058	Belongs to the CinA family
HUT18_RS27270	COG1546	Belongs to the CinA family
HUT18_RS27275	COG1396	sequence-specific DNA binding
HUT18_RS27280	COG0783	Belongs to the Dps family
HUT18_RS27290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT18_RS27295	COG1201	RNA secondary structure unwinding
HUT18_RS27300	COG2207	Transcriptional regulator
HUT18_RS27300	COG1917	Cupin 2, conserved barrel domain protein
HUT18_RS27330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUT18_RS27335	COG2137	regulation of response to DNA damage stimulus
HUT18_RS27340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT18_RS27355	COG0765	amino acid transport
HUT18_RS27360	COG0765	amino acid transport
HUT18_RS27365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT18_RS27370	COG1126	abc transporter atp-binding protein
HUT18_RS27380	COG2205	protein histidine kinase activity
HUT18_RS27400	COG0395	ABC-type sugar transport system, permease component
HUT18_RS27405	COG1175	transmembrane transport
HUT18_RS27410	COG1653	transport
HUT18_RS27415	COG1609	Transcriptional regulator
HUT18_RS27435	COG0523	cobalamin synthesis protein
HUT18_RS27445	COG0701	Predicted permease
HUT18_RS27455	COG1309	transcriptional regulator
HUT18_RS27460	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS27470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT18_RS27490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT18_RS27505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUT18_RS27515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUT18_RS27520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT18_RS27525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUT18_RS27555	COG0601	transmembrane transport
HUT18_RS27560	COG4166	transmembrane transport
HUT18_RS27575	COG0019	diaminopimelate decarboxylase activity
HUT18_RS27580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT18_RS27585	COG0534	Mate efflux family protein
HUT18_RS27625	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS27645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUT18_RS27650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT18_RS27675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT18_RS27710	COG2186	Transcriptional regulator
HUT18_RS27715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT18_RS27730	COG0187	DNA topoisomerase II activity
HUT18_RS27735	COG4585	Histidine kinase
HUT18_RS27740	COG2197	response regulator
HUT18_RS27750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT18_RS27760	COG3290	protein histidine kinase activity
HUT18_RS27770	COG0372	Belongs to the citrate synthase family
HUT18_RS27775	COG0372	Belongs to the citrate synthase family
HUT18_RS27790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT18_RS27795	COG0612	Peptidase, M16
HUT18_RS27810	COG1802	Transcriptional regulator
HUT18_RS27815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT18_RS27830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT18_RS27835	COG1435	thymidine kinase activity
HUT18_RS27885	COG0745	RESPONSE REGULATOR receiver
HUT18_RS27890	COG2205	protein histidine kinase activity
HUT18_RS27915	COG0756	dUTP diphosphatase activity
HUT18_RS27950	COG0569	domain protein
HUT18_RS27955	COG0531	amino acid
HUT18_RS27960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT18_RS27980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT18_RS27985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT18_RS28035	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HUT18_RS28045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT18_RS28050	COG0154	amidase activity
HUT18_RS28055	COG1304	FMN binding
HUT18_RS28070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT18_RS28090	COG2423	ornithine cyclodeaminase activity
HUT18_RS28105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT18_RS28125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT18_RS28140	COG0463	Glycosyl transferase, family 2
HUT18_RS28150	COG4310	Domain of unknown function (DUF2172)
HUT18_RS28165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT18_RS28175	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS28200	COG0367	asparagine synthase
HUT18_RS28220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT18_RS28240	COG0726	polysaccharide deacetylase
HUT18_RS28255	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS28270	COG0512	Glutamine amidotransferase of anthranilate synthase
HUT18_RS28270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUT18_RS28275	COG2124	cytochrome p450
HUT18_RS28310	COG0500	methyltransferase
HUT18_RS28315	COG2207	Transcriptional regulator
HUT18_RS28325	COG3387	PFAM Glycoside hydrolase 15-related
HUT18_RS28340	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS28345	COG0438	transferase activity, transferring glycosyl groups
HUT18_RS28410	COG0346	lactoylglutathione lyase activity
HUT18_RS28415	COG0583	DNA-binding transcription factor activity
HUT18_RS28445	COG3290	protein histidine kinase activity
HUT18_RS28515	COG0673	inositol 2-dehydrogenase activity
HUT18_RS28535	COG1609	Transcriptional regulator
HUT18_RS28555	COG1175	transmembrane transport
HUT18_RS28560	COG0395	ABC-type sugar transport system, permease component
HUT18_RS28565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUT18_RS28650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT18_RS28660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUT18_RS28670	COG1773	rubredoxin
HUT18_RS28720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUT18_RS28725	COG1799	cell septum assembly
HUT18_RS28760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT18_RS28775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS28830	COG4948	Mandelate Racemase Muconate Lactonizing
HUT18_RS28845	COG0800	Aldolase
HUT18_RS28850	COG3386	PFAM SMP-30 Gluconolaconase
HUT18_RS28855	COG1940	carbohydrate kinase activity
HUT18_RS28870	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT18_RS28875	COG1129	ABC transporter
HUT18_RS28895	COG0395	ABC-type sugar transport system, permease component
HUT18_RS28900	COG1175	transmembrane transport
HUT18_RS28905	COG1609	Transcriptional regulator
HUT18_RS28910	COG1609	Transcriptional regulator
HUT18_RS28940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT18_RS28950	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS28960	COG2957	Belongs to the agmatine deiminase family
HUT18_RS28965	COG2957	Belongs to the agmatine deiminase family
HUT18_RS28975	COG0832	Belongs to the urease beta subunit family
HUT18_RS28975	COG0831	urea catabolic process
HUT18_RS28980	COG0804	urea catabolic process
HUT18_RS28985	COG2957	Belongs to the agmatine deiminase family
HUT18_RS28990	COG0747	negative chemotaxis
HUT18_RS29000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT18_RS29010	COG4608	Belongs to the ABC transporter superfamily
HUT18_RS29015	COG2957	Belongs to the agmatine deiminase family
HUT18_RS29060	COG1902	pentaerythritol trinitrate reductase activity
HUT18_RS29060	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT18_RS29070	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS29095	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS29100	COG3268	Saccharopine dehydrogenase
HUT18_RS29110	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS29115	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS29120	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS29135	COG2409	Drug exporters of the RND superfamily
HUT18_RS29145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT18_RS29160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUT18_RS29165	COG1653	transport
HUT18_RS29170	COG1175	transmembrane transport
HUT18_RS29175	COG0395	ABC-type sugar transport system, permease component
HUT18_RS29215	COG4213	ABC transporter substrate-binding protein
HUT18_RS29225	COG4214	carbohydrate transport
HUT18_RS29230	COG0477	Major facilitator Superfamily
HUT18_RS29235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT18_RS29240	COG0531	amino acid
HUT18_RS29245	COG0741	lytic transglycosylase activity
HUT18_RS29245	COG0739	heme binding
HUT18_RS29245	COG1196	nuclear chromosome segregation
HUT18_RS29260	COG1024	Enoyl-CoA hydratase
HUT18_RS29260	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT18_RS29265	COG0183	Belongs to the thiolase family
HUT18_RS29270	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUT18_RS29285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUT18_RS29290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT18_RS29320	COG3220	belongs to the UPF0276 family
HUT18_RS29365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUT18_RS29370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT18_RS29415	COG1280	lysine exporter protein (LysE YggA)
HUT18_RS29485	COG0456	acetyltransferase
HUT18_RS29510	COG1175	transmembrane transport
HUT18_RS29555	COG0395	ABC-type sugar transport system, permease component
HUT18_RS29560	COG1175	transmembrane transport
HUT18_RS29565	COG1653	transport
HUT18_RS29585	COG0667	Aldo Keto reductase
HUT18_RS29595	COG0583	DNA-binding transcription factor activity
HUT18_RS29600	COG0667	Aldo Keto reductase
HUT18_RS29620	COG2267	carboxylic ester hydrolase activity
HUT18_RS29650	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT18_RS29655	COG2409	Drug exporters of the RND superfamily
HUT18_RS29680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT18_RS29710	COG0529	Catalyzes the synthesis of activated sulfate
HUT18_RS29715	COG0175	sulfate reduction
HUT18_RS29740	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS29750	COG0702	epimerase
HUT18_RS29790	COG1302	Protein conserved in bacteria
HUT18_RS29875	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS29885	COG2197	response regulator
HUT18_RS29890	COG4585	Histidine kinase
HUT18_RS29895	COG1131	(ABC) transporter
HUT18_RS29910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUT18_RS29930	COG1162	GTPase activity
HUT18_RS29950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT18_RS29985	COG0028	Belongs to the TPP enzyme family
HUT18_RS30005	COG1802	Transcriptional regulator
HUT18_RS30035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT18_RS30040	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUT18_RS30040	COG3608	succinylglutamate desuccinylase aspartoacylase
HUT18_RS30050	COG2755	lipolytic protein G-D-S-L family
HUT18_RS30050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT18_RS30060	COG2080	2 iron, 2 sulfur cluster binding
HUT18_RS30065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT18_RS30070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT18_RS30105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT18_RS30115	COG0477	Major facilitator Superfamily
HUT18_RS30130	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT18_RS30130	COG1672	PFAM Archaeal ATPase
HUT18_RS30165	COG1556	Lactate utilization protein
HUT18_RS30170	COG1139	Iron-sulfur cluster binding protein
HUT18_RS30175	COG0247	lactate metabolic process
HUT18_RS30185	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS30190	COG4948	Mandelate Racemase Muconate Lactonizing
HUT18_RS30195	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT18_RS30205	COG1129	ABC transporter
HUT18_RS30210	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT18_RS30215	COG2186	Transcriptional regulator
HUT18_RS30220	COG2340	Cysteine-rich secretory protein family
HUT18_RS30245	COG0318	PFAM AMP-dependent synthetase and ligase
HUT18_RS30265	COG2351	hydroxyisourate hydrolase activity
HUT18_RS30290	COG0588	phosphoglycerate mutase activity
HUT18_RS30305	COG0739	heme binding
HUT18_RS30345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT18_RS30350	COG4266	Belongs to the allantoicase family
HUT18_RS30355	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS30380	COG2197	response regulator
HUT18_RS30390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT18_RS30430	COG0673	inositol 2-dehydrogenase activity
HUT18_RS30435	COG2188	Transcriptional regulator
HUT18_RS30455	COG1940	carbohydrate kinase activity
HUT18_RS30465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT18_RS30620	COG0488	(ABC) transporter
HUT18_RS30625	COG0277	FAD linked oxidase domain protein
HUT18_RS30665	COG1073	alpha beta
HUT18_RS30675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT18_RS30690	COG1357	PFAM Pentapeptide repeats (8 copies)
HUT18_RS30710	COG0405	Gamma-glutamyltransferase
HUT18_RS30730	COG0483	inositol monophosphate 1-phosphatase activity
HUT18_RS30740	COG1609	Transcriptional regulator
HUT18_RS30745	COG3511	phospholipase C
HUT18_RS30760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT18_RS30765	COG1929	Belongs to the glycerate kinase type-1 family
HUT18_RS30775	COG0688	phosphatidylethanolamine metabolic process
HUT18_RS30780	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS30790	COG2301	Belongs to the HpcH HpaI aldolase family
HUT18_RS30795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS30795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT18_RS30800	COG0604	alcohol dehydrogenase
HUT18_RS30810	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT18_RS30870	COG2045	Belongs to the ComB family
HUT18_RS30875	COG2362	D-Aminopeptidase
HUT18_RS30880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT18_RS30890	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT18_RS30900	COG0662	Cupin 2, conserved barrel domain protein
HUT18_RS30925	COG4106	trans-aconitate 2-methyltransferase activity
HUT18_RS30950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT18_RS30975	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT18_RS30980	COG2264	protein methyltransferase activity
HUT18_RS30985	COG0656	L-ascorbic acid biosynthetic process
HUT18_RS31005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUT18_RS31010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT18_RS31020	COG3290	protein histidine kinase activity
HUT18_RS31030	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS31035	COG1024	Enoyl-CoA hydratase
HUT18_RS31040	COG1024	Enoyl-CoA hydratase
HUT18_RS31045	COG0477	Major facilitator Superfamily
HUT18_RS31050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT18_RS31070	COG0765	amino acid transport
HUT18_RS31075	COG1126	abc transporter atp-binding protein
HUT18_RS31080	COG0436	Aminotransferase
HUT18_RS31085	COG2186	Transcriptional regulator
HUT18_RS31095	COG0473	3-isopropylmalate dehydrogenase activity
HUT18_RS31115	COG1024	Enoyl-CoA hydratase
HUT18_RS31145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT18_RS31145	COG1672	PFAM Archaeal ATPase
HUT18_RS31155	COG1793	dna ligase
HUT18_RS31185	COG0488	(ABC) transporter
HUT18_RS31200	COG1515	deoxyribonuclease V activity
HUT18_RS31205	COG3268	Saccharopine dehydrogenase
HUT18_RS31210	COG2826	transposase and inactivated derivatives, IS30 family
HUT18_RS31220	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS31225	COG0183	Belongs to the thiolase family
HUT18_RS31230	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT18_RS31230	COG1024	Enoyl-CoA hydratase
HUT18_RS31235	COG0789	Transcriptional regulator
HUT18_RS31240	COG1113	amino acid transport
HUT18_RS31260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT18_RS31270	COG0488	(ABC) transporter
HUT18_RS31275	COG2183	response to ionizing radiation
HUT18_RS31295	COG1024	Enoyl-CoA hydratase
HUT18_RS31305	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT18_RS31325	COG0371	Dehydrogenase
HUT18_RS31345	COG1134	teichoic acid transport
HUT18_RS31350	COG1562	ergosterol biosynthetic process
HUT18_RS31360	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT18_RS31370	COG1657	PFAM Prenyltransferase squalene oxidase
HUT18_RS31375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT18_RS31445	COG1063	alcohol dehydrogenase
HUT18_RS31450	COG0156	8-amino-7-oxononanoate synthase activity
HUT18_RS31455	COG0583	DNA-binding transcription factor activity
HUT18_RS31465	COG2838	Isocitrate dehydrogenase
HUT18_RS31475	COG0183	Belongs to the thiolase family
HUT18_RS31510	COG3629	intracellular signal transduction
HUT18_RS31510	COG3903	Transcriptional regulator
HUT18_RS31520	COG2318	DinB family
HUT18_RS31530	COG1051	belongs to the nudix hydrolase family
HUT18_RS31540	COG1132	(ABC) transporter
HUT18_RS31550	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT18_RS31555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT18_RS31560	COG4521	taurine ABC transporter
HUT18_RS31585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT18_RS31605	COG1175	transmembrane transport
HUT18_RS31610	COG0395	ABC-type sugar transport system, permease component
HUT18_RS31635	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS31640	COG0583	DNA-binding transcription factor activity
HUT18_RS31655	COG3345	alpha-galactosidase
HUT18_RS31665	COG3290	protein histidine kinase activity
HUT18_RS31670	COG1802	Transcriptional regulator
HUT18_RS31675	COG0800	Aldolase
HUT18_RS31680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT18_RS31685	COG3386	PFAM SMP-30 Gluconolaconase
HUT18_RS31690	COG0477	Major facilitator Superfamily
HUT18_RS31695	COG4948	Mandelate Racemase Muconate Lactonizing
HUT18_RS31710	COG1802	Transcriptional regulator
HUT18_RS31715	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS31720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT18_RS31730	COG0395	ABC-type sugar transport system, permease component
HUT18_RS31735	COG1175	transmembrane transport
HUT18_RS31745	COG3119	arylsulfatase activity
HUT18_RS31750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT18_RS31790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT18_RS31805	COG3458	cephalosporin-C deacetylase activity
HUT18_RS31850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT18_RS31910	COG1053	succinate dehydrogenase
HUT18_RS31915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT18_RS31920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS31935	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUT18_RS31940	COG0121	glutamine amidotransferase
HUT18_RS31945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT18_RS31960	COG1609	Transcriptional regulator
HUT18_RS31965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT18_RS31975	COG2813	Specifically methylates the guanine in position
HUT18_RS31995	COG0579	oxidoreductase
HUT18_RS32025	COG0477	Major facilitator Superfamily
HUT18_RS32050	COG4585	Histidine kinase
HUT18_RS32055	COG2197	response regulator
HUT18_RS32060	COG1796	DNA polymerase
HUT18_RS32060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT18_RS32100	COG1024	Enoyl-CoA hydratase
HUT18_RS32110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT18_RS32120	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS32135	COG2186	Transcriptional regulator
HUT18_RS32140	COG2186	Transcriptional regulator
HUT18_RS32145	COG1028	Short-chain dehydrogenase reductase Sdr
HUT18_RS32150	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT18_RS32155	COG0247	lactate metabolic process
HUT18_RS32160	COG1139	Iron-sulfur cluster binding protein
HUT18_RS32165	COG1556	Lactate utilization protein
HUT18_RS32170	COG2271	Major facilitator Superfamily
HUT18_RS32185	COG1022	Amp-dependent synthetase and ligase
HUT18_RS32195	COG2304	oxidoreductase activity
HUT18_RS32235	COG0673	inositol 2-dehydrogenase activity
HUT18_RS32250	COG0395	ABC-type sugar transport system, permease component
HUT18_RS32255	COG4209	transmembrane transport
HUT18_RS32290	COG2197	response regulator
HUT18_RS32310	COG0431	NADPH-dependent FMN reductase
HUT18_RS32320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT18_RS32340	COG0666	response to abiotic stimulus
HUT18_RS32350	COG4585	Histidine kinase
HUT18_RS32355	COG2197	response regulator
HUT18_RS32380	COG0110	maltose O-acetyltransferase activity
HUT18_RS32395	COG0009	L-threonylcarbamoyladenylate synthase
HUT18_RS32400	COG1024	Enoyl-CoA hydratase
HUT18_RS32400	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT18_RS32410	COG1404	Belongs to the peptidase S8 family
HUT18_RS32415	COG0181	hydroxymethylbilane synthase activity
HUT18_RS32420	COG1012	belongs to the aldehyde dehydrogenase family
HUT18_RS32430	COG0517	IMP dehydrogenase activity
HUT18_RS32430	COG4175	Glycine betaine
HUT18_RS32435	COG4176	ABC-type proline glycine betaine transport system permease component
HUT18_RS32455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT18_RS32460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT18_RS32475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT18_RS32485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT18_RS32490	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HUT18_RS32495	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HUT18_RS32500	COG0235	Class ii aldolase
HUT18_RS32500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUT18_RS32505	COG0235	Class ii aldolase
HUT18_RS32505	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUT18_RS32525	COG1940	carbohydrate kinase activity
HUT18_RS32535	COG1175	transmembrane transport
HUT18_RS32540	COG0395	ABC-type sugar transport system, permease component
HUT18_RS32555	COG5492	domain, Protein
HUT18_RS32570	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT18_RS32590	COG1940	carbohydrate kinase activity
HUT18_RS32605	COG2197	response regulator
HUT18_RS32620	COG3433	isochorismatase activity
HUT18_RS32620	COG2226	methyltransferase
HUT18_RS32620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT18_RS32655	COG1595	DNA-templated transcription, initiation
HUT18_RS32670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT18_RS32675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT18_RS32715	COG1113	amino acid transport
HUT18_RS32755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT18_RS32760	COG0789	Transcriptional regulator
HUT18_RS32780	COG2226	methyltransferase
HUT18_RS32785	COG0204	Acyl-transferase
HUT18_RS32800	COG3442	glutamine amidotransferase
HUT18_RS32810	COG0242	peptide deformylase activity
HUT18_RS32820	COG1960	acyl-CoA dehydrogenase activity
HUT18_RS32835	COG1793	dna ligase
HUT18_RS32880	COG1595	DNA-templated transcription, initiation
HUT18_RS32915	COG0242	peptide deformylase activity
HUT18_RS32935	COG0604	alcohol dehydrogenase
HUT18_RS32940	COG2365	Tyrosine phosphatase family
HUT18_RS32965	COG2124	cytochrome p450
HUT18_RS32995	COG0640	Transcriptional regulator
HUT18_RS33005	COG2986	histidine ammonia-lyase
HUT18_RS33035	COG0477	Major facilitator Superfamily
HUT18_RS33050	COG1120	ATPase activity
HUT18_RS33095	COG2124	cytochrome p450
HUT18_RS33100	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HUT18_RS33115	COG3424	synthase
HUT18_RS33125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUT18_RS33130	COG2345	Transcriptional regulator
HUT18_RS33135	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT18_RS33180	COG0142	geranyltranstransferase activity