locus-tag	class	description
L2I08_RS00010	COG0006	proline dipeptidase activity
L2I08_RS00025	COG0653	protein targeting
L2I08_RS00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2I08_RS00060	COG1595	DNA-templated transcription, initiation
L2I08_RS00065	COG0318	PFAM AMP-dependent synthetase and ligase
L2I08_RS00120	COG0745	RESPONSE REGULATOR receiver
L2I08_RS00130	COG0477	Major facilitator Superfamily
L2I08_RS00150	COG0477	Major facilitator Superfamily
L2I08_RS00165	COG1191	sigma factor activity
L2I08_RS00170	COG1191	sigma factor activity
L2I08_RS00205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L2I08_RS00270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2I08_RS00275	COG2837	iron assimilation
L2I08_RS00285	COG0659	secondary active sulfate transmembrane transporter activity
L2I08_RS00315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2I08_RS00340	COG2189	Belongs to the N(4) N(6)-methyltransferase family
L2I08_RS00360	COG0151	Belongs to the GarS family
L2I08_RS00375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L2I08_RS00385	COG2197	response regulator
L2I08_RS00420	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2I08_RS00425	COG0047	phosphoribosylformylglycinamidine synthase activity
L2I08_RS00430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2I08_RS00445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L2I08_RS00480	COG1643	Atp-dependent helicase
L2I08_RS00485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2I08_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS00505	COG1063	alcohol dehydrogenase
L2I08_RS00525	COG0604	alcohol dehydrogenase
L2I08_RS00530	COG2814	Major facilitator Superfamily
L2I08_RS00540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2I08_RS00545	COG1846	Transcriptional regulator
L2I08_RS00555	COG2814	Major facilitator Superfamily
L2I08_RS00625	COG0513	Belongs to the DEAD box helicase family
L2I08_RS00655	COG0542	response to heat
L2I08_RS00685	COG0667	Aldo Keto reductase
L2I08_RS00695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2I08_RS00700	COG0579	oxidoreductase
L2I08_RS00715	COG0366	Alpha amylase catalytic
L2I08_RS00715	COG1470	cell adhesion involved in biofilm formation
L2I08_RS00805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2I08_RS00860	COG2197	response regulator
L2I08_RS00875	COG0666	response to abiotic stimulus
L2I08_RS00885	COG1733	regulation of RNA biosynthetic process
L2I08_RS00950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L2I08_RS00955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2I08_RS01005	COG2130	NADP-dependent
L2I08_RS01025	COG0596	Alpha beta hydrolase
L2I08_RS01050	COG2318	DinB family
L2I08_RS01065	COG1136	(ABC) transporter
L2I08_RS01065	COG0577	efflux transmembrane transporter activity
L2I08_RS01080	COG1408	metallophosphoesterase
L2I08_RS01100	COG0003	Pfam Anion-transporting ATPase
L2I08_RS01115	COG0251	oxidation-reduction process
L2I08_RS01125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2I08_RS01155	COG2267	carboxylic ester hydrolase activity
L2I08_RS01165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2I08_RS01170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2I08_RS01175	COG0659	secondary active sulfate transmembrane transporter activity
L2I08_RS01235	COG1111	helicase
L2I08_RS01235	COG1205	dead DEAH box helicase
L2I08_RS01240	COG1366	Belongs to the anti-sigma-factor antagonist family
L2I08_RS01255	COG2890	protein-(glutamine-N5) methyltransferase activity
L2I08_RS01265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2I08_RS01265	COG1754	DNA topoisomerase type I activity
L2I08_RS01270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L2I08_RS01300	COG0789	Transcriptional regulator
L2I08_RS01315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2I08_RS01320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2I08_RS01335	COG0789	Transcriptional regulator
L2I08_RS01345	COG0825	malonyl-CoA metabolic process
L2I08_RS01345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L2I08_RS01350	COG0318	PFAM AMP-dependent synthetase and ligase
L2I08_RS01360	COG2186	Transcriptional regulator
L2I08_RS01390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2I08_RS01400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2I08_RS01410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2I08_RS01465	COG1252	NADH dehydrogenase
L2I08_RS01475	COG0640	Transcriptional regulator
L2I08_RS01485	COG1316	TRANSCRIPTIONal
L2I08_RS01490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2I08_RS01505	COG0793	Belongs to the peptidase S41A family
L2I08_RS01510	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L2I08_RS01525	COG5001	Diguanylate cyclase
L2I08_RS01545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS01550	COG1120	ATPase activity
L2I08_RS01555	COG0783	Belongs to the Dps family
L2I08_RS01590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2I08_RS01595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2I08_RS01620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L2I08_RS01660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L2I08_RS01665	COG2264	protein methyltransferase activity
L2I08_RS01750	COG2076	Multidrug Resistance protein
L2I08_RS01765	COG5002	protein histidine kinase activity
L2I08_RS01770	COG0745	RESPONSE REGULATOR receiver
L2I08_RS01780	COG1329	Transcriptional regulator
L2I08_RS01785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L2I08_RS01790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L2I08_RS01810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS01825	COG0215	cysteine-tRNA ligase activity
L2I08_RS01840	COG1253	flavin adenine dinucleotide binding
L2I08_RS01850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L2I08_RS01860	COG3842	ATPase activity
L2I08_RS01870	COG2814	Major facilitator Superfamily
L2I08_RS01905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2I08_RS01905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2I08_RS01915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2I08_RS01915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2I08_RS01925	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L2I08_RS01935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2I08_RS01945	COG0436	Aminotransferase
L2I08_RS01950	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2I08_RS01955	COG0456	acetyltransferase
L2I08_RS01990	COG2208	phosphoserine phosphatase activity
L2I08_RS01990	COG2770	Histidine kinase
L2I08_RS02020	COG1278	Cold shock
L2I08_RS02025	COG0513	Belongs to the DEAD box helicase family
L2I08_RS02045	COG0301	tRNA thio-modification
L2I08_RS02065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L2I08_RS02070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L2I08_RS02075	COG2197	response regulator
L2I08_RS02080	COG4585	Histidine kinase
L2I08_RS02120	COG1902	pentaerythritol trinitrate reductase activity
L2I08_RS02130	COG0577	efflux transmembrane transporter activity
L2I08_RS02135	COG1136	(ABC) transporter
L2I08_RS02135	COG0577	efflux transmembrane transporter activity
L2I08_RS02160	COG2172	sigma factor antagonist activity
L2I08_RS02165	COG1366	Belongs to the anti-sigma-factor antagonist family
L2I08_RS02170	COG1366	Belongs to the anti-sigma-factor antagonist family
L2I08_RS02250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2I08_RS02330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2I08_RS02395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L2I08_RS02420	COG1105	Belongs to the carbohydrate kinase PfkB family
L2I08_RS02460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2I08_RS02485	COG0463	Glycosyl transferase, family 2
L2I08_RS02500	COG1278	Cold shock
L2I08_RS02540	COG0667	Aldo Keto reductase
L2I08_RS02545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2I08_RS02545	COG1263	PTS System
L2I08_RS02550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L2I08_RS02555	COG1737	Transcriptional regulator
L2I08_RS02565	COG0406	alpha-ribazole phosphatase activity
L2I08_RS02605	COG2197	response regulator
L2I08_RS02660	COG3973	AAA domain
L2I08_RS02685	COG0789	Transcriptional regulator
L2I08_RS02690	COG0667	Aldo Keto reductase
L2I08_RS02730	COG1061	Type III restriction enzyme res subunit
L2I08_RS02790	COG2124	cytochrome p450
L2I08_RS02800	COG1295	ribonuclease BN
L2I08_RS02810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS02815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS02820	COG1120	ATPase activity
L2I08_RS02825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L2I08_RS02830	COG0515	serine threonine protein kinase
L2I08_RS02840	COG1132	(ABC) transporter
L2I08_RS02845	COG1132	(ABC) transporter
L2I08_RS02850	COG2197	response regulator
L2I08_RS02865	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L2I08_RS02870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2I08_RS02880	COG2814	Major facilitator Superfamily
L2I08_RS02905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2I08_RS02915	COG2252	PERMEase
L2I08_RS02940	COG0667	Aldo Keto reductase
L2I08_RS03035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L2I08_RS03045	COG2124	cytochrome p450
L2I08_RS03065	COG2205	protein histidine kinase activity
L2I08_RS03070	COG0247	lactate metabolic process
L2I08_RS03070	COG0277	FAD linked oxidase domain protein
L2I08_RS03080	COG0583	DNA-binding transcription factor activity
L2I08_RS03115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2I08_RS03130	COG1024	Enoyl-CoA hydratase
L2I08_RS03150	COG0259	pyridoxamine-phosphate oxidase activity
L2I08_RS03160	COG4821	SIS domain
L2I08_RS03240	COG1366	Belongs to the anti-sigma-factor antagonist family
L2I08_RS03260	COG2271	Major facilitator Superfamily
L2I08_RS03265	COG2072	flavoprotein involved in K transport
L2I08_RS03285	COG1309	transcriptional regulator
L2I08_RS03290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2I08_RS03290	COG0515	serine threonine protein kinase
L2I08_RS03330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2I08_RS03360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L2I08_RS03375	COG0148	phosphopyruvate hydratase activity
L2I08_RS03395	COG5297	Belongs to the glycosyl hydrolase family 6
L2I08_RS03480	COG1278	Cold shock
L2I08_RS03495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2I08_RS03530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2I08_RS03535	COG2151	metal-sulfur cluster biosynthetic enzyme
L2I08_RS03540	COG3396	Phenylacetate-CoA oxygenase
L2I08_RS03545	COG3460	Phenylacetate-CoA oxygenase
L2I08_RS03550	COG3396	Phenylacetate-CoA oxygenase
L2I08_RS03555	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS03560	COG1024	Enoyl-CoA hydratase
L2I08_RS03565	COG0183	Belongs to the thiolase family
L2I08_RS03575	COG2050	protein possibly involved in aromatic compounds catabolism
L2I08_RS03630	COG1846	Transcriptional regulator
L2I08_RS03635	COG3384	dioxygenase
L2I08_RS03655	COG3191	aminopeptidase activity
L2I08_RS03670	COG1970	mechanosensitive ion channel activity
L2I08_RS03685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L2I08_RS03700	COG3263	regulation of cellular component size
L2I08_RS03710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2I08_RS03715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2I08_RS03725	COG0315	cyclic pyranopterin monophosphate synthase activity
L2I08_RS03730	COG0315	cyclic pyranopterin monophosphate synthase activity
L2I08_RS03730	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2I08_RS03775	COG2197	response regulator
L2I08_RS03795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2I08_RS03805	COG0708	Exodeoxyribonuclease III
L2I08_RS03815	COG2072	flavoprotein involved in K transport
L2I08_RS03825	COG4221	oxidoreductase activity
L2I08_RS03835	COG0793	Belongs to the peptidase S41A family
L2I08_RS03835	COG4946	Tricorn protease homolog
L2I08_RS03845	COG2409	Drug exporters of the RND superfamily
L2I08_RS03855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2I08_RS03915	COG0084	hydrolase, TatD family'
L2I08_RS03920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2I08_RS03925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L2I08_RS03930	COG0488	(ABC) transporter
L2I08_RS03975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L2I08_RS03980	COG2197	response regulator
L2I08_RS03990	COG4106	trans-aconitate 2-methyltransferase activity
L2I08_RS04010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L2I08_RS04020	COG0193	aminoacyl-tRNA hydrolase activity
L2I08_RS04025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L2I08_RS04050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2I08_RS04055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L2I08_RS04065	COG4585	Histidine kinase
L2I08_RS04090	COG0789	Transcriptional regulator
L2I08_RS04110	COG1316	TRANSCRIPTIONal
L2I08_RS04120	COG2267	carboxylic ester hydrolase activity
L2I08_RS04160	COG0477	Major facilitator Superfamily
L2I08_RS04170	COG3629	intracellular signal transduction
L2I08_RS04170	COG3903	Transcriptional regulator
L2I08_RS04225	COG1473	amidohydrolase
L2I08_RS04235	COG3226	Transcriptional regulator
L2I08_RS04240	COG0154	amidase activity
L2I08_RS04275	COG1733	regulation of RNA biosynthetic process
L2I08_RS04315	COG2124	cytochrome p450
L2I08_RS04330	COG0148	phosphopyruvate hydratase activity
L2I08_RS04360	COG1252	NADH dehydrogenase
L2I08_RS04365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2I08_RS04370	COG1136	(ABC) transporter
L2I08_RS04370	COG0577	efflux transmembrane transporter activity
L2I08_RS04375	COG1136	(ABC) transporter
L2I08_RS04385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2I08_RS04400	COG1476	TRANSCRIPTIONal
L2I08_RS04420	COG0183	Belongs to the thiolase family
L2I08_RS04425	COG2755	lipolytic protein G-D-S-L family
L2I08_RS04485	COG0395	ABC-type sugar transport system, permease component
L2I08_RS04505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2I08_RS04515	COG1228	amidohydrolase
L2I08_RS04520	COG1191	sigma factor activity
L2I08_RS04525	COG1366	Belongs to the anti-sigma-factor antagonist family
L2I08_RS04535	COG3104	oligopeptide transport
L2I08_RS04540	COG0745	RESPONSE REGULATOR receiver
L2I08_RS04545	COG2205	protein histidine kinase activity
L2I08_RS04560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L2I08_RS04585	COG2072	flavoprotein involved in K transport
L2I08_RS04595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L2I08_RS04680	COG3046	protein related to deoxyribodipyrimidine photolyase
L2I08_RS04685	COG1316	TRANSCRIPTIONal
L2I08_RS04705	COG1316	TRANSCRIPTIONal
L2I08_RS04735	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
L2I08_RS04735	COG0778	Nitroreductase
L2I08_RS04740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L2I08_RS04775	COG1620	l-lactate permease
L2I08_RS04785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2I08_RS04795	COG2835	tetraacyldisaccharide 4'-kinase activity
L2I08_RS04805	COG1482	cell wall glycoprotein biosynthetic process
L2I08_RS04815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2I08_RS04850	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L2I08_RS04855	COG0714	Associated with various cellular activities
L2I08_RS04875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L2I08_RS04880	COG0745	RESPONSE REGULATOR receiver
L2I08_RS04885	COG5002	protein histidine kinase activity
L2I08_RS04890	COG0823	Involved in the tonB-independent uptake of proteins
L2I08_RS04900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L2I08_RS04905	COG2197	response regulator
L2I08_RS04910	COG3214	Protein conserved in bacteria
L2I08_RS04915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2I08_RS04920	COG0653	protein targeting
L2I08_RS04925	COG0583	DNA-binding transcription factor activity
L2I08_RS04935	COG0583	DNA-binding transcription factor activity
L2I08_RS04955	COG2902	Dehydrogenase
L2I08_RS04970	COG2226	methyltransferase
L2I08_RS04980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2I08_RS04995	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS05000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2I08_RS05005	COG0395	ABC-type sugar transport system, permease component
L2I08_RS05010	COG1175	transmembrane transport
L2I08_RS05015	COG1653	transport
L2I08_RS05020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L2I08_RS05025	COG1716	ATPase activity
L2I08_RS05030	COG0515	serine threonine protein kinase
L2I08_RS05035	COG0515	serine threonine protein kinase
L2I08_RS05040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L2I08_RS05055	COG2884	Cell division ATP-binding protein ftsE
L2I08_RS05065	COG0793	Belongs to the peptidase S41A family
L2I08_RS05070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L2I08_RS05085	COG0583	DNA-binding transcription factor activity
L2I08_RS05140	COG3973	AAA domain
L2I08_RS05140	COG3973	AAA domain
L2I08_RS05150	COG0776	regulation of translation
L2I08_RS05155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2I08_RS05160	COG1678	Uncharacterized ACR, COG1678
L2I08_RS05175	COG1175	transmembrane transport
L2I08_RS05180	COG0395	ABC-type sugar transport system, permease component
L2I08_RS05185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L2I08_RS05200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2I08_RS05230	COG2318	DinB family
L2I08_RS05265	COG1116	anion transmembrane transporter activity
L2I08_RS05310	COG1174	glycine betaine transport
L2I08_RS05315	COG0517	IMP dehydrogenase activity
L2I08_RS05315	COG1125	glycine betaine transport
L2I08_RS05320	COG1174	glycine betaine transport
L2I08_RS05330	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L2I08_RS05340	COG0277	FAD linked oxidase domain protein
L2I08_RS05375	COG2205	protein histidine kinase activity
L2I08_RS05380	COG0745	RESPONSE REGULATOR receiver
L2I08_RS05410	COG1335	isochorismatase
L2I08_RS05420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2I08_RS05435	COG1113	amino acid transport
L2I08_RS05460	COG1234	tRNA 3'-trailer cleavage
L2I08_RS05470	COG1263	PTS System
L2I08_RS05480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L2I08_RS05490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L2I08_RS05515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L2I08_RS05525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2I08_RS05555	COG2733	membrane
L2I08_RS05565	COG2271	Major facilitator Superfamily
L2I08_RS05610	COG0706	membrane insertase activity
L2I08_RS05615	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2I08_RS05620	COG0673	inositol 2-dehydrogenase activity
L2I08_RS05675	COG3397	chitin binding
L2I08_RS05705	COG1126	abc transporter atp-binding protein
L2I08_RS05710	COG0765	amino acid transport
L2I08_RS05715	COG0765	amino acid transport
L2I08_RS05720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2I08_RS05740	COG3473	Maleate cis-trans isomerase
L2I08_RS05750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS05815	COG1554	hydrolase, family 65, central catalytic
L2I08_RS05870	COG1217	gtp-binding protein TYPA
L2I08_RS05880	COG0601	transmembrane transport
L2I08_RS05885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS05890	COG0444	Belongs to the ABC transporter superfamily
L2I08_RS05895	COG4608	Belongs to the ABC transporter superfamily
L2I08_RS05905	COG0601	transmembrane transport
L2I08_RS05910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS05920	COG4608	Belongs to the ABC transporter superfamily
L2I08_RS05945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L2I08_RS05965	COG3250	beta-galactosidase activity
L2I08_RS05970	COG1879	ABC-type sugar transport system periplasmic component
L2I08_RS05975	COG1129	ABC transporter
L2I08_RS05985	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS05990	COG1609	Transcriptional regulator
L2I08_RS06000	COG2912	Transglutaminase-like superfamily
L2I08_RS06005	COG0456	acetyltransferase
L2I08_RS06035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2I08_RS06075	COG0519	Catalyzes the synthesis of GMP from XMP
L2I08_RS06085	COG1024	Enoyl-CoA hydratase
L2I08_RS06100	COG1595	DNA-templated transcription, initiation
L2I08_RS06110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2I08_RS06115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2I08_RS06155	COG0598	Magnesium transport protein CorA
L2I08_RS06165	COG2814	Major facilitator Superfamily
L2I08_RS06170	COG0613	PHP domain protein
L2I08_RS06175	COG2095	MarC family integral membrane protein
L2I08_RS06185	COG1432	Conserved Protein
L2I08_RS06285	COG0210	DNA helicase
L2I08_RS06380	COG3480	Lon protease (S16) C-terminal proteolytic domain
L2I08_RS06390	COG1615	UPF0182 protein
L2I08_RS06415	COG0753	catalase activity
L2I08_RS06420	COG0483	inositol monophosphate 1-phosphatase activity
L2I08_RS06430	COG2076	Multidrug Resistance protein
L2I08_RS06440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2I08_RS06450	COG2135	peptidase activity
L2I08_RS06460	COG1595	DNA-templated transcription, initiation
L2I08_RS06465	COG5662	AntiSigma factor
L2I08_RS06475	COG0242	peptide deformylase activity
L2I08_RS06485	COG2124	cytochrome p450
L2I08_RS06505	COG1966	Carbon starvation protein
L2I08_RS06510	COG2188	Transcriptional regulator
L2I08_RS06515	COG2182	Extracellular solute-binding protein
L2I08_RS06520	COG1175	transmembrane transport
L2I08_RS06525	COG0395	ABC-type sugar transport system, permease component
L2I08_RS06530	COG1472	Belongs to the glycosyl hydrolase 3 family
L2I08_RS06535	COG0363	glucosamine-6-phosphate deaminase activity
L2I08_RS06550	COG1597	lipid kinase activity
L2I08_RS06565	COG2172	sigma factor antagonist activity
L2I08_RS06580	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2I08_RS06600	COG1959	2 iron, 2 sulfur cluster binding
L2I08_RS06605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2I08_RS06615	COG0142	geranyltranstransferase activity
L2I08_RS06665	COG4106	trans-aconitate 2-methyltransferase activity
L2I08_RS06670	COG1126	abc transporter atp-binding protein
L2I08_RS06685	COG0281	malic enzyme
L2I08_RS06690	COG0604	alcohol dehydrogenase
L2I08_RS06740	COG2255	four-way junction helicase activity
L2I08_RS06770	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2I08_RS06770	COG0567	Dehydrogenase, E1 component
L2I08_RS06775	COG2205	protein histidine kinase activity
L2I08_RS06780	COG0745	RESPONSE REGULATOR receiver
L2I08_RS06800	COG1131	(ABC) transporter
L2I08_RS06810	COG1595	DNA-templated transcription, initiation
L2I08_RS06825	COG0477	Major facilitator Superfamily
L2I08_RS06830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L2I08_RS06835	COG0726	polysaccharide deacetylase
L2I08_RS06910	COG0772	Belongs to the SEDS family
L2I08_RS06925	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L2I08_RS06930	COG2267	carboxylic ester hydrolase activity
L2I08_RS06940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2I08_RS06940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2I08_RS06945	COG1191	sigma factor activity
L2I08_RS06955	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS06980	COG0018	arginyl-trna synthetase
L2I08_RS06985	COG0019	diaminopimelate decarboxylase activity
L2I08_RS06990	COG0460	homoserine dehydrogenase
L2I08_RS06995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2I08_RS07000	COG0083	homoserine kinase activity
L2I08_RS07010	COG1316	TRANSCRIPTIONal
L2I08_RS07015	COG0254	rRNA binding
L2I08_RS07020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L2I08_RS07025	COG2890	protein-(glutamine-N5) methyltransferase activity
L2I08_RS07035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2I08_RS07040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2I08_RS07055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2I08_RS07060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L2I08_RS07065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2I08_RS07070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L2I08_RS07075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L2I08_RS07080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L2I08_RS07085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L2I08_RS07105	COG2197	response regulator
L2I08_RS07110	COG4585	Histidine kinase
L2I08_RS07125	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS07140	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
L2I08_RS07175	COG1131	(ABC) transporter
L2I08_RS07195	COG0183	Belongs to the thiolase family
L2I08_RS07225	COG1335	isochorismatase
L2I08_RS07295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L2I08_RS07295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L2I08_RS07335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2I08_RS07340	COG0280	phosphate acetyltransferase
L2I08_RS07340	COG0857	belongs to the CobB CobQ family
L2I08_RS07345	COG0205	6-phosphofructokinase activity
L2I08_RS07350	COG4565	transcriptional regulatory protein
L2I08_RS07355	COG3290	protein histidine kinase activity
L2I08_RS07360	COG1301	dicarboxylic acid transport
L2I08_RS07375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2I08_RS07380	COG1119	ATPase activity
L2I08_RS07395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L2I08_RS07405	COG3281	Trehalose synthase
L2I08_RS07410	COG0366	Alpha amylase catalytic
L2I08_RS07415	COG0366	Alpha amylase catalytic
L2I08_RS07435	COG1733	regulation of RNA biosynthetic process
L2I08_RS07445	COG1132	(ABC) transporter
L2I08_RS07450	COG1132	(ABC) transporter
L2I08_RS07475	COG1376	ErfK ybiS ycfS ynhG family protein
L2I08_RS07500	COG2085	NADP oxidoreductase coenzyme F420-dependent
L2I08_RS07525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2I08_RS07540	COG0477	Major facilitator Superfamily
L2I08_RS07555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L2I08_RS07560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2I08_RS07565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2I08_RS07585	COG1760	l-serine dehydratase
L2I08_RS07590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L2I08_RS07595	COG0509	glycine decarboxylation via glycine cleavage system
L2I08_RS07600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L2I08_RS07620	COG0747	negative chemotaxis
L2I08_RS07625	COG0601	transmembrane transport
L2I08_RS07630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS07635	COG0444	Belongs to the ABC transporter superfamily
L2I08_RS07640	COG4608	Belongs to the ABC transporter superfamily
L2I08_RS07645	COG2860	membrane
L2I08_RS07670	COG0482	sulfurtransferase activity
L2I08_RS07690	COG4221	oxidoreductase activity
L2I08_RS07700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2I08_RS07710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2I08_RS07715	COG0154	amidase activity
L2I08_RS07725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2I08_RS07730	COG2409	Drug exporters of the RND superfamily
L2I08_RS07750	COG2197	response regulator
L2I08_RS07770	COG2133	pyrroloquinoline quinone binding
L2I08_RS07775	COG0667	Aldo Keto reductase
L2I08_RS07795	COG0440	acetolactate synthase activity
L2I08_RS07800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L2I08_RS07810	COG2890	protein-(glutamine-N5) methyltransferase activity
L2I08_RS07830	COG3835	regulator
L2I08_RS07835	COG0506	proline dehydrogenase activity
L2I08_RS07840	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS07865	COG0473	3-isopropylmalate dehydrogenase activity
L2I08_RS07870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2I08_RS07875	COG0831	urea catabolic process
L2I08_RS07875	COG0832	Belongs to the urease beta subunit family
L2I08_RS07880	COG0804	urea catabolic process
L2I08_RS07885	COG2957	Belongs to the agmatine deiminase family
L2I08_RS07890	COG0477	Major facilitator Superfamily
L2I08_RS07895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2I08_RS07925	COG4221	oxidoreductase activity
L2I08_RS07945	COG0789	Transcriptional regulator
L2I08_RS07985	COG2353	YceI-like domain
L2I08_RS07995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2I08_RS08015	COG2018	Roadblock/LC7 domain
L2I08_RS08035	COG2018	Roadblock/LC7 domain
L2I08_RS08050	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2I08_RS08055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2I08_RS08100	COG1414	Transcriptional regulator
L2I08_RS08105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L2I08_RS08110	COG0066	3-isopropylmalate dehydratase activity
L2I08_RS08120	COG0776	regulation of translation
L2I08_RS08130	COG1920	GTP binding
L2I08_RS08140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L2I08_RS08145	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2I08_RS08165	COG0351	phosphomethylpyrimidine kinase
L2I08_RS08170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L2I08_RS08175	COG1461	Dihydroxyacetone kinase
L2I08_RS08185	COG0742	ribosomal rna small subunit methyltransferase
L2I08_RS08190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L2I08_RS08205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L2I08_RS08210	COG0571	ribonuclease III activity
L2I08_RS08215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L2I08_RS08230	COG2188	Transcriptional regulator
L2I08_RS08260	COG2340	Cysteine-rich secretory protein family
L2I08_RS08265	COG1254	Belongs to the acylphosphatase family
L2I08_RS08275	COG1196	nuclear chromosome segregation
L2I08_RS08280	COG0477	Major facilitator Superfamily
L2I08_RS08310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L2I08_RS08320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2I08_RS08335	COG0228	four-way junction DNA binding
L2I08_RS08340	COG1837	Belongs to the UPF0109 family
L2I08_RS08345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2I08_RS08350	COG0336	Belongs to the RNA methyltransferase TrmD family
L2I08_RS08355	COG0335	large ribosomal subunit rRNA binding
L2I08_RS08360	COG0681	Belongs to the peptidase S26 family
L2I08_RS08370	COG0681	Belongs to the peptidase S26 family
L2I08_RS08375	COG0681	Belongs to the peptidase S26 family
L2I08_RS08390	COG0792	nuclease activity
L2I08_RS08405	COG1191	sigma factor activity
L2I08_RS08420	COG0052	Belongs to the universal ribosomal protein uS2 family
L2I08_RS08425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L2I08_RS08430	COG0528	UMP kinase activity
L2I08_RS08435	COG0233	cytoplasmic translational termination
L2I08_RS08440	COG0575	Belongs to the CDS family
L2I08_RS08445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L2I08_RS08455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2I08_RS08460	COG3842	ATPase activity
L2I08_RS08480	COG1136	(ABC) transporter
L2I08_RS08485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L2I08_RS08495	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS08500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2I08_RS08515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2I08_RS08530	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS08540	COG3842	ATPase activity
L2I08_RS08545	COG1176	ABC-type spermidine putrescine transport system, permease component I
L2I08_RS08550	COG1177	transmembrane transport
L2I08_RS08555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2I08_RS08585	COG2508	Transcriptional regulator
L2I08_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS08595	COG1940	carbohydrate kinase activity
L2I08_RS08600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L2I08_RS08605	COG0750	zinc metalloprotease
L2I08_RS08610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L2I08_RS08625	COG0747	negative chemotaxis
L2I08_RS08630	COG0601	transmembrane transport
L2I08_RS08635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS08655	COG0442	prolyl-tRNA aminoacylation
L2I08_RS08675	COG0779	Required for maturation of 30S ribosomal subunits
L2I08_RS08690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L2I08_RS08700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L2I08_RS08705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2I08_RS08720	COG1357	PFAM Pentapeptide repeats (8 copies)
L2I08_RS08725	COG4608	Belongs to the ABC transporter superfamily
L2I08_RS08730	COG0444	Belongs to the ABC transporter superfamily
L2I08_RS08735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS08740	COG0601	transmembrane transport
L2I08_RS08745	COG0747	negative chemotaxis
L2I08_RS08750	COG0455	bacterial-type flagellum organization
L2I08_RS08760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L2I08_RS08765	COG1185	polyribonucleotide nucleotidyltransferase activity
L2I08_RS08770	COG0612	Peptidase, M16
L2I08_RS08775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L2I08_RS08795	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L2I08_RS08800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2I08_RS08805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L2I08_RS08835	COG2770	Histidine kinase
L2I08_RS08835	COG2208	phosphoserine phosphatase activity
L2I08_RS08840	COG3850	Histidine kinase
L2I08_RS08840	COG4999	Histidine kinase
L2I08_RS08840	COG3437	response regulator, receiver
L2I08_RS08840	COG2205	protein histidine kinase activity
L2I08_RS08850	COG1674	ftsk spoiiie
L2I08_RS08860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2I08_RS08870	COG1546	Belongs to the CinA family
L2I08_RS08870	COG1058	Belongs to the CinA family
L2I08_RS08875	COG1396	sequence-specific DNA binding
L2I08_RS08880	COG0783	Belongs to the Dps family
L2I08_RS08890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L2I08_RS08910	COG0596	Alpha beta hydrolase
L2I08_RS08915	COG1201	RNA secondary structure unwinding
L2I08_RS08940	COG0628	permease
L2I08_RS08965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L2I08_RS08970	COG2137	regulation of response to DNA damage stimulus
L2I08_RS08985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2I08_RS08990	COG0765	amino acid transport
L2I08_RS08995	COG0765	amino acid transport
L2I08_RS09000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2I08_RS09005	COG1126	abc transporter atp-binding protein
L2I08_RS09010	COG0745	RESPONSE REGULATOR receiver
L2I08_RS09015	COG2205	protein histidine kinase activity
L2I08_RS09025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2I08_RS09045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L2I08_RS09055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L2I08_RS09060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2I08_RS09070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2I08_RS09110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2I08_RS09115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L2I08_RS09120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2I08_RS09145	COG0588	phosphoglycerate mutase activity
L2I08_RS09160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2I08_RS09195	COG1802	Transcriptional regulator
L2I08_RS09200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L2I08_RS09215	COG0187	DNA topoisomerase II activity
L2I08_RS09235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2I08_RS09250	COG1653	transport
L2I08_RS09255	COG1175	transmembrane transport
L2I08_RS09260	COG0395	ABC-type sugar transport system, permease component
L2I08_RS09265	COG0366	Alpha amylase catalytic
L2I08_RS09275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L2I08_RS09280	COG0612	Peptidase, M16
L2I08_RS09295	COG1802	Transcriptional regulator
L2I08_RS09300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2I08_RS09350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L2I08_RS09355	COG0483	inositol monophosphate 1-phosphatase activity
L2I08_RS09365	COG0745	RESPONSE REGULATOR receiver
L2I08_RS09370	COG2205	protein histidine kinase activity
L2I08_RS09395	COG0756	dUTP diphosphatase activity
L2I08_RS09415	COG1136	(ABC) transporter
L2I08_RS09415	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2I08_RS09445	COG0569	domain protein
L2I08_RS09450	COG0531	amino acid
L2I08_RS09455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L2I08_RS09480	COG0210	DNA helicase
L2I08_RS09515	COG4974	Belongs to the 'phage' integrase family
L2I08_RS09540	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS09550	COG3210	domain, Protein
L2I08_RS09595	COG1136	(ABC) transporter
L2I08_RS09605	COG2197	response regulator
L2I08_RS09610	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS09625	COG1063	alcohol dehydrogenase
L2I08_RS09630	COG0395	ABC-type sugar transport system, permease component
L2I08_RS09665	COG0559	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS09680	COG0402	S-adenosylhomocysteine deaminase activity
L2I08_RS09685	COG2233	PERMEase
L2I08_RS09775	COG1127	ABC transporter
L2I08_RS09785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2I08_RS09810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2I08_RS09845	COG0656	L-ascorbic acid biosynthetic process
L2I08_RS09860	COG0473	3-isopropylmalate dehydrogenase activity
L2I08_RS09870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2I08_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS09935	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS09945	COG0252	asparaginase activity
L2I08_RS09950	COG1846	Transcriptional regulator
L2I08_RS09950	COG1940	carbohydrate kinase activity
L2I08_RS09955	COG1129	ABC transporter
L2I08_RS09960	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS09965	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS09970	COG4213	ABC transporter substrate-binding protein
L2I08_RS09985	COG0738	Major facilitator superfamily
L2I08_RS09990	COG3226	Transcriptional regulator
L2I08_RS10035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L2I08_RS10055	COG0640	Transcriptional regulator
L2I08_RS10065	COG0789	Transcriptional regulator
L2I08_RS10080	COG2050	protein possibly involved in aromatic compounds catabolism
L2I08_RS10090	COG3540	Alkaline phosphatase
L2I08_RS10110	COG2936	dipeptidyl-peptidase activity
L2I08_RS10125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2I08_RS10140	COG1309	transcriptional regulator
L2I08_RS10150	COG0747	negative chemotaxis
L2I08_RS10160	COG0601	transmembrane transport
L2I08_RS10165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS10190	COG1733	regulation of RNA biosynthetic process
L2I08_RS10200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS10205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS10210	COG1120	ATPase activity
L2I08_RS10225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2I08_RS10235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2I08_RS10275	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L2I08_RS10285	COG1620	l-lactate permease
L2I08_RS10290	COG0247	lactate metabolic process
L2I08_RS10295	COG1139	Iron-sulfur cluster binding protein
L2I08_RS10300	COG1556	Lactate utilization protein
L2I08_RS10315	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L2I08_RS10325	COG1799	cell septum assembly
L2I08_RS10365	COG2235	arginine
L2I08_RS10370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L2I08_RS10375	COG0531	amino acid
L2I08_RS10405	COG2124	cytochrome p450
L2I08_RS10415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2I08_RS10415	COG2111	Na H antiporter
L2I08_RS10425	COG0651	ATP synthesis coupled electron transport
L2I08_RS10440	COG1320	monovalent cation:proton antiporter activity
L2I08_RS10445	COG2235	arginine
L2I08_RS10465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2I08_RS10475	COG1120	ATPase activity
L2I08_RS10495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2I08_RS10525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2I08_RS10530	COG1653	transport
L2I08_RS10535	COG1175	transmembrane transport
L2I08_RS10540	COG0395	ABC-type sugar transport system, permease component
L2I08_RS10550	COG4213	ABC transporter substrate-binding protein
L2I08_RS10560	COG4214	carbohydrate transport
L2I08_RS10565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L2I08_RS10570	COG0531	amino acid
L2I08_RS10590	COG1024	Enoyl-CoA hydratase
L2I08_RS10590	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS10595	COG0183	Belongs to the thiolase family
L2I08_RS10615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L2I08_RS10620	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2I08_RS10630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L2I08_RS10635	COG3253	May function as heme-dependent peroxidase
L2I08_RS10645	COG3220	belongs to the UPF0276 family
L2I08_RS10655	COG0726	polysaccharide deacetylase
L2I08_RS10670	COG1595	DNA-templated transcription, initiation
L2I08_RS10675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L2I08_RS10695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2I08_RS10700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2I08_RS10765	COG2176	DNA-directed DNA polymerase activity
L2I08_RS10765	COG5002	protein histidine kinase activity
L2I08_RS10800	COG0386	Belongs to the glutathione peroxidase family
L2I08_RS10815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2I08_RS10820	COG1116	anion transmembrane transporter activity
L2I08_RS10845	COG0529	Catalyzes the synthesis of activated sulfate
L2I08_RS10850	COG0175	sulfate reduction
L2I08_RS10860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2I08_RS10885	COG0604	alcohol dehydrogenase
L2I08_RS10890	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS10910	COG2040	homocysteine
L2I08_RS10935	COG2255	four-way junction helicase activity
L2I08_RS10945	COG1120	ATPase activity
L2I08_RS10950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS10960	COG2409	Drug exporters of the RND superfamily
L2I08_RS10965	COG1846	Transcriptional regulator
L2I08_RS10970	COG0702	epimerase
L2I08_RS10980	COG0789	Transcriptional regulator
L2I08_RS10990	COG1595	DNA-templated transcription, initiation
L2I08_RS11030	COG2365	Tyrosine phosphatase family
L2I08_RS11040	COG1162	GTPase activity
L2I08_RS11045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2I08_RS11065	COG0028	Belongs to the TPP enzyme family
L2I08_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS11095	COG1802	Transcriptional regulator
L2I08_RS11105	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L2I08_RS11110	COG3835	regulator
L2I08_RS11125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2I08_RS11130	COG2252	PERMEase
L2I08_RS11165	COG0494	nUDIX hydrolase
L2I08_RS11170	COG1309	transcriptional regulator
L2I08_RS11180	COG2197	response regulator
L2I08_RS11185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2I08_RS11190	COG0318	PFAM AMP-dependent synthetase and ligase
L2I08_RS11200	COG3960	tartronate-semialdehyde synthase activity
L2I08_RS11210	COG0753	catalase activity
L2I08_RS11215	COG2084	Dehydrogenase
L2I08_RS11220	COG3622	Belongs to the hyi family
L2I08_RS11240	COG2351	hydroxyisourate hydrolase activity
L2I08_RS11255	COG2233	PERMEase
L2I08_RS11310	COG1609	Transcriptional regulator
L2I08_RS11330	COG1621	beta-fructofuranosidase activity
L2I08_RS11335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2I08_RS11340	COG3795	YCII-related domain
L2I08_RS11345	COG4941	Belongs to the sigma-70 factor family
L2I08_RS11360	COG1309	transcriptional regulator
L2I08_RS11365	COG2197	response regulator
L2I08_RS11375	COG0656	L-ascorbic acid biosynthetic process
L2I08_RS11390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2I08_RS11395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2I08_RS11400	COG0022	dehydrogenase e1 component
L2I08_RS11410	COG2124	cytochrome p450
L2I08_RS11415	COG1819	glycosyl
L2I08_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS11455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L2I08_RS11480	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS11485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2I08_RS11495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2I08_RS11525	COG0235	Class ii aldolase
L2I08_RS11535	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS11550	COG0667	Aldo Keto reductase
L2I08_RS11565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2I08_RS11570	COG2080	2 iron, 2 sulfur cluster binding
L2I08_RS11575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L2I08_RS11580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2I08_RS11595	COG1414	Transcriptional regulator
L2I08_RS11600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L2I08_RS11615	COG4585	Histidine kinase
L2I08_RS11620	COG2197	response regulator
L2I08_RS11635	COG0673	inositol 2-dehydrogenase activity
L2I08_RS11640	COG2188	Transcriptional regulator
L2I08_RS11650	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS11660	COG1940	carbohydrate kinase activity
L2I08_RS11670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2I08_RS11755	COG0464	growth
L2I08_RS11765	COG2197	response regulator
L2I08_RS11795	COG2207	Transcriptional regulator
L2I08_RS11800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2I08_RS11805	COG2375	cellular response to nickel ion
L2I08_RS11810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS11815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS11820	COG1120	ATPase activity
L2I08_RS11825	COG1132	(ABC) transporter
L2I08_RS11830	COG1132	(ABC) transporter
L2I08_RS11835	COG2133	pyrroloquinoline quinone binding
L2I08_RS11835	COG5183	chlorophyll binding
L2I08_RS11865	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS11885	COG2267	carboxylic ester hydrolase activity
L2I08_RS11895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2I08_RS11900	COG1228	amidohydrolase
L2I08_RS11930	COG1126	abc transporter atp-binding protein
L2I08_RS11935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2I08_RS11940	COG0765	amino acid transport
L2I08_RS11945	COG0765	amino acid transport
L2I08_RS11975	COG0405	Gamma-glutamyltransferase
L2I08_RS12000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L2I08_RS12020	COG0095	Lipoate-protein ligase
L2I08_RS12030	COG0483	inositol monophosphate 1-phosphatase activity
L2I08_RS12045	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L2I08_RS12060	COG0159	tryptophan synthase activity
L2I08_RS12085	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L2I08_RS12095	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS12100	COG0702	epimerase
L2I08_RS12105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2I08_RS12120	COG0488	(ABC) transporter
L2I08_RS12125	COG1929	Belongs to the glycerate kinase type-1 family
L2I08_RS12135	COG0688	phosphatidylethanolamine metabolic process
L2I08_RS12150	COG2301	Belongs to the HpcH HpaI aldolase family
L2I08_RS12155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L2I08_RS12155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L2I08_RS12160	COG0604	alcohol dehydrogenase
L2I08_RS12170	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS12175	COG1120	ATPase activity
L2I08_RS12180	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS12185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS12230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2I08_RS12240	COG1619	proteins homologs of microcin C7 resistance protein MccF
L2I08_RS12260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2I08_RS12275	COG0604	alcohol dehydrogenase
L2I08_RS12285	COG3226	Transcriptional regulator
L2I08_RS12300	COG4106	trans-aconitate 2-methyltransferase activity
L2I08_RS12305	COG1597	lipid kinase activity
L2I08_RS12315	COG0693	protein deglycase activity
L2I08_RS12375	COG1140	nitrate reductase beta subunit
L2I08_RS12405	COG2154	pterin-4-alpha-carbinolamine dehydratase
L2I08_RS12430	COG1115	amino acid carrier protein
L2I08_RS12435	COG0583	DNA-binding transcription factor activity
L2I08_RS12445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2I08_RS12460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2I08_RS12465	COG1940	carbohydrate kinase activity
L2I08_RS12470	COG1129	ABC transporter
L2I08_RS12475	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS12485	COG0673	inositol 2-dehydrogenase activity
L2I08_RS12550	COG1295	ribonuclease BN
L2I08_RS12570	COG1609	Transcriptional regulator
L2I08_RS12575	COG1129	ABC transporter
L2I08_RS12580	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS12585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2I08_RS12590	COG1869	D-ribose catabolic process
L2I08_RS12600	COG2259	Doxx family
L2I08_RS12605	COG2814	Major facilitator Superfamily
L2I08_RS12625	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS12685	COG1846	Transcriptional regulator
L2I08_RS12730	COG0789	Transcriptional regulator
L2I08_RS12765	COG1024	Enoyl-CoA hydratase
L2I08_RS12770	COG1793	dna ligase
L2I08_RS12780	COG0254	rRNA binding
L2I08_RS12815	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS12835	COG0488	(ABC) transporter
L2I08_RS12845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2I08_RS12845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2I08_RS12855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2I08_RS12885	COG1515	deoxyribonuclease V activity
L2I08_RS12895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2I08_RS12905	COG0183	Belongs to the thiolase family
L2I08_RS12910	COG1024	Enoyl-CoA hydratase
L2I08_RS12910	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS12915	COG0789	Transcriptional regulator
L2I08_RS12920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2I08_RS12950	COG0402	S-adenosylhomocysteine deaminase activity
L2I08_RS12955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L2I08_RS12960	COG1802	Transcriptional regulator
L2I08_RS12975	COG2183	response to ionizing radiation
L2I08_RS12990	COG1024	Enoyl-CoA hydratase
L2I08_RS13005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L2I08_RS13020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L2I08_RS13045	COG1388	LysM domain
L2I08_RS13045	COG1134	teichoic acid transport
L2I08_RS13050	COG1562	ergosterol biosynthetic process
L2I08_RS13060	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L2I08_RS13070	COG1657	PFAM Prenyltransferase squalene oxidase
L2I08_RS13100	COG2365	Tyrosine phosphatase family
L2I08_RS13105	COG2755	lipolytic protein G-D-S-L family
L2I08_RS13175	COG3958	Transketolase
L2I08_RS13180	COG3959	Transketolase, thiamine diphosphate binding domain
L2I08_RS13200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2I08_RS13205	COG4521	taurine ABC transporter
L2I08_RS13240	COG0740	serine-type endopeptidase activity
L2I08_RS13245	COG0740	serine-type endopeptidase activity
L2I08_RS13250	COG1396	sequence-specific DNA binding
L2I08_RS13290	COG2391	methyltransferase activity
L2I08_RS13295	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS13300	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS13305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2I08_RS13310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2I08_RS13315	COG0583	DNA-binding transcription factor activity
L2I08_RS13320	COG0183	Belongs to the thiolase family
L2I08_RS13325	COG0477	Major facilitator Superfamily
L2I08_RS13395	COG1233	COG1233 Phytoene dehydrogenase and related
L2I08_RS13400	COG2130	NADP-dependent
L2I08_RS13405	COG2124	cytochrome p450
L2I08_RS13415	COG1070	Carbohydrate kinase
L2I08_RS13440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2I08_RS13485	COG2018	Roadblock/LC7 domain
L2I08_RS13500	COG1946	Acyl-CoA thioesterase
L2I08_RS13515	COG1132	(ABC) transporter
L2I08_RS13520	COG1132	(ABC) transporter
L2I08_RS13540	COG1132	(ABC) transporter
L2I08_RS13545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2I08_RS13550	COG0492	ferredoxin-NADP+ reductase activity
L2I08_RS13555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS13565	COG1116	anion transmembrane transporter activity
L2I08_RS13570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2I08_RS13575	COG0432	Pfam Uncharacterised protein family UPF0047
L2I08_RS13580	COG1609	Transcriptional regulator
L2I08_RS13590	COG1175	transmembrane transport
L2I08_RS13600	COG1472	Belongs to the glycosyl hydrolase 3 family
L2I08_RS13610	COG1309	transcriptional regulator
L2I08_RS13615	COG0477	Major facilitator Superfamily
L2I08_RS13635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L2I08_RS13655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L2I08_RS13670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2I08_RS13695	COG2814	Major facilitator Superfamily
L2I08_RS13700	COG2207	Transcriptional regulator
L2I08_RS13705	COG1120	ATPase activity
L2I08_RS13710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2I08_RS13755	COG0583	DNA-binding transcription factor activity
L2I08_RS13760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2I08_RS13780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2I08_RS13785	COG0303	'Molybdopterin
L2I08_RS13800	COG0243	molybdopterin cofactor binding
L2I08_RS13805	COG0076	glutamate decarboxylase activity
L2I08_RS13810	COG0071	Belongs to the small heat shock protein (HSP20) family
L2I08_RS13815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2I08_RS13825	COG2706	6-phosphogluconolactonase activity
L2I08_RS13840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L2I08_RS13855	COG1902	pentaerythritol trinitrate reductase activity
L2I08_RS13860	COG0640	Transcriptional regulator
L2I08_RS13865	COG2233	PERMEase
L2I08_RS13895	COG0671	phosphoesterase, PA-phosphatase related
L2I08_RS13915	COG1846	Transcriptional regulator
L2I08_RS13930	COG0584	glycerophosphoryl diester phosphodiesterase
L2I08_RS13970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L2I08_RS13995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2I08_RS14010	COG2197	response regulator
L2I08_RS14025	COG2223	nitrite transmembrane transporter activity
L2I08_RS14035	COG1940	carbohydrate kinase activity
L2I08_RS14055	COG1349	DNA-binding transcription factor activity
L2I08_RS14075	COG0633	Ferredoxin
L2I08_RS14075	COG3217	Mosc domain protein beta barrel domain protein
L2I08_RS14090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2I08_RS14100	COG0513	Belongs to the DEAD box helicase family
L2I08_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS14140	COG1695	Transcriptional regulator
L2I08_RS14170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2I08_RS14195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2I08_RS14200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2I08_RS14200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2I08_RS14205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2I08_RS14205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2I08_RS14205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2I08_RS14215	COG1349	DNA-binding transcription factor activity
L2I08_RS14230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2I08_RS14240	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS14250	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS14260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2I08_RS14275	COG1120	ATPase activity
L2I08_RS14290	COG0640	Transcriptional regulator
L2I08_RS14295	COG0346	lactoylglutathione lyase activity
L2I08_RS14305	COG0702	epimerase
L2I08_RS14325	COG0326	Molecular chaperone. Has ATPase activity
L2I08_RS14345	COG1131	(ABC) transporter
L2I08_RS14350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2I08_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS14410	COG0149	triose-phosphate isomerase activity
L2I08_RS14430	COG1595	DNA-templated transcription, initiation
L2I08_RS14460	COG0431	NADPH-dependent FMN reductase
L2I08_RS14465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS14470	COG0328	RNA-DNA hybrid ribonuclease activity
L2I08_RS14485	COG0477	Major facilitator Superfamily
L2I08_RS14505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2I08_RS14520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2I08_RS14530	COG2197	response regulator
L2I08_RS14550	COG0475	glutathione-regulated potassium exporter activity
L2I08_RS14585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2I08_RS14595	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2I08_RS14595	COG1902	pentaerythritol trinitrate reductase activity
L2I08_RS14615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS14625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L2I08_RS14635	COG0713	ATP synthesis coupled electron transport
L2I08_RS14640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2I08_RS14645	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS14650	COG1007	ATP synthesis coupled electron transport
L2I08_RS14670	COG2267	carboxylic ester hydrolase activity
L2I08_RS14685	COG2084	Dehydrogenase
L2I08_RS14715	COG2356	endonuclease I
L2I08_RS14725	COG2813	Specifically methylates the guanine in position
L2I08_RS14730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2I08_RS14735	COG0589	response to stress
L2I08_RS14740	COG0318	PFAM AMP-dependent synthetase and ligase
L2I08_RS14795	COG0277	FAD linked oxidase domain protein
L2I08_RS14830	COG1793	dna ligase
L2I08_RS14865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2I08_RS14880	COG0601	transmembrane transport
L2I08_RS14885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS14890	COG0444	Belongs to the ABC transporter superfamily
L2I08_RS14895	COG4608	Belongs to the ABC transporter superfamily
L2I08_RS14945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L2I08_RS14945	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2I08_RS15020	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2I08_RS15025	COG4585	Histidine kinase
L2I08_RS15030	COG2197	response regulator
L2I08_RS15040	COG2080	2 iron, 2 sulfur cluster binding
L2I08_RS15045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L2I08_RS15050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2I08_RS15075	COG0477	Major facilitator Superfamily
L2I08_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS15100	COG1175	transmembrane transport
L2I08_RS15105	COG0395	ABC-type sugar transport system, permease component
L2I08_RS15110	COG1609	Transcriptional regulator
L2I08_RS15115	COG1874	Beta-galactosidase
L2I08_RS15120	COG1472	Belongs to the glycosyl hydrolase 3 family
L2I08_RS15165	COG1857	crispr-associated protein
L2I08_RS15185	COG0305	Participates in initiation and elongation during chromosome replication
L2I08_RS15250	COG2801	Transposase and inactivated derivatives
L2I08_RS15340	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
L2I08_RS15395	COG3547	Transposase (IS116 IS110 IS902 family)
L2I08_RS15470	COG0494	nUDIX hydrolase
L2I08_RS15545	COG0739	heme binding
L2I08_RS15545	COG0741	lytic transglycosylase activity
L2I08_RS15545	COG1196	nuclear chromosome segregation
L2I08_RS15580	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2I08_RS15585	COG3246	L-lysine catabolic process to acetate
L2I08_RS15615	COG0477	Major facilitator Superfamily
L2I08_RS15640	COG4335	DNA alkylation repair
L2I08_RS15655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2I08_RS15655	COG0300	oxidoreductase activity
L2I08_RS15655	COG3321	synthase
L2I08_RS15655	COG4221	oxidoreductase activity
L2I08_RS15735	COG0515	serine threonine protein kinase
L2I08_RS15785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2I08_RS15795	COG0604	alcohol dehydrogenase
L2I08_RS15810	COG3396	Phenylacetate-CoA oxygenase
L2I08_RS15820	COG3396	Phenylacetate-CoA oxygenase
L2I08_RS15825	COG2151	metal-sulfur cluster biosynthetic enzyme
L2I08_RS15830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2I08_RS15835	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS15840	COG3483	tryptophan 2,3-dioxygenase activity
L2I08_RS15870	COG1129	ABC transporter
L2I08_RS15880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2I08_RS15915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2I08_RS15920	COG2124	cytochrome p450
L2I08_RS15940	COG0604	alcohol dehydrogenase
L2I08_RS15940	COG3321	synthase
L2I08_RS15955	COG0604	alcohol dehydrogenase
L2I08_RS15955	COG3321	synthase
L2I08_RS15970	COG0604	alcohol dehydrogenase
L2I08_RS15970	COG3321	synthase
L2I08_RS16010	COG0142	geranyltranstransferase activity
L2I08_RS16020	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS16070	COG2814	Major facilitator Superfamily
L2I08_RS16080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L2I08_RS16085	COG0277	FAD linked oxidase domain protein
L2I08_RS16110	COG2318	DinB family
L2I08_RS16115	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
L2I08_RS16125	COG1124	(ABC) transporter
L2I08_RS16130	COG0444	Belongs to the ABC transporter superfamily
L2I08_RS16135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS16140	COG0601	transmembrane transport
L2I08_RS16150	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS16155	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS16180	COG1125	glycine betaine transport
L2I08_RS16180	COG0517	IMP dehydrogenase activity
L2I08_RS16190	COG1174	glycine betaine transport
L2I08_RS16195	COG1174	glycine betaine transport
L2I08_RS16200	COG2124	cytochrome p450
L2I08_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS16235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS16240	COG4608	Belongs to the ABC transporter superfamily
L2I08_RS16250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2I08_RS16280	COG0235	Class ii aldolase
L2I08_RS16285	COG3395	kinase activity
L2I08_RS16300	COG1349	DNA-binding transcription factor activity
L2I08_RS16320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2I08_RS16330	COG3971	2-oxopent-4-enoate hydratase activity
L2I08_RS16335	COG1414	Transcriptional regulator
L2I08_RS16360	COG0242	peptide deformylase activity
L2I08_RS16375	COG0110	maltose O-acetyltransferase activity
L2I08_RS16385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2I08_RS16390	COG1132	(ABC) transporter
L2I08_RS16395	COG1132	(ABC) transporter
L2I08_RS16420	COG1120	ATPase activity
L2I08_RS16430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS16460	COG1984	allophanate hydrolase subunit 2
L2I08_RS16465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L2I08_RS16470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L2I08_RS16505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2I08_RS16515	COG0300	oxidoreductase activity
L2I08_RS16520	COG2201	protein-glutamate methylesterase activity
L2I08_RS16550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2I08_RS16555	COG0590	tRNA wobble adenosine to inosine editing
L2I08_RS16560	COG0363	glucosamine-6-phosphate deaminase activity
L2I08_RS16565	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
L2I08_RS16575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2I08_RS16585	COG3458	cephalosporin-C deacetylase activity
L2I08_RS16595	COG0747	negative chemotaxis
L2I08_RS16600	COG0601	transmembrane transport
L2I08_RS16605	COG0444	Belongs to the ABC transporter superfamily
L2I08_RS16610	COG4608	Belongs to the ABC transporter superfamily
L2I08_RS16615	COG1121	(ABC) transporter
L2I08_RS16620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2I08_RS16630	COG0803	Belongs to the bacterial solute-binding protein 9 family
L2I08_RS16640	COG4257	antibiotic catabolic process
L2I08_RS16650	COG3655	Transcriptional regulator
L2I08_RS16740	COG4948	Mandelate Racemase Muconate Lactonizing
L2I08_RS16745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2I08_RS16760	COG3119	arylsulfatase activity
L2I08_RS16790	COG0477	Major facilitator Superfamily
L2I08_RS16820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L2I08_RS16825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L2I08_RS16830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2I08_RS16835	COG0254	rRNA binding
L2I08_RS16845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L2I08_RS16870	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
L2I08_RS16885	COG3293	Transposase
L2I08_RS16910	COG0142	geranyltranstransferase activity
L2I08_RS16915	COG1796	DNA polymerase
L2I08_RS16915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L2I08_RS16925	COG2837	iron assimilation
L2I08_RS16945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2I08_RS16950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2I08_RS16970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2I08_RS16975	COG0121	glutamine amidotransferase
L2I08_RS16980	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L2I08_RS16985	COG2182	Extracellular solute-binding protein
L2I08_RS16990	COG3360	Dodecin
L2I08_RS17000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS17005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2I08_RS17010	COG1053	succinate dehydrogenase
L2I08_RS17020	COG0583	DNA-binding transcription factor activity
L2I08_RS17085	COG3275	phosphorelay sensor kinase activity
L2I08_RS17090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2I08_RS17100	COG3279	Response regulator of the LytR AlgR family
L2I08_RS17105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L2I08_RS17140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L2I08_RS17145	COG2313	pseudouridylate synthase activity
L2I08_RS17155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2I08_RS17160	COG0546	phosphoglycolate phosphatase activity
L2I08_RS17165	COG0697	spore germination
L2I08_RS17185	COG1132	(ABC) transporter
L2I08_RS17195	COG1595	DNA-templated transcription, initiation
L2I08_RS17205	COG0656	L-ascorbic acid biosynthetic process
L2I08_RS17225	COG0784	Response regulator, receiver
L2I08_RS17230	COG4251	negative regulation of phosphorylation
L2I08_RS17275	COG0501	Belongs to the peptidase M48B family
L2I08_RS17280	COG2723	6-phospho-beta-galactosidase activity
L2I08_RS17285	COG0395	ABC-type sugar transport system, permease component
L2I08_RS17290	COG1175	transmembrane transport
L2I08_RS17315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2I08_RS17335	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS17345	COG0242	peptide deformylase activity
L2I08_RS17355	COG3442	glutamine amidotransferase
L2I08_RS17360	COG0205	6-phosphofructokinase activity
L2I08_RS17375	COG2770	Histidine kinase
L2I08_RS17375	COG2208	phosphoserine phosphatase activity
L2I08_RS17385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L2I08_RS17385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L2I08_RS17390	COG0435	Glutathione S-transferase
L2I08_RS17400	COG2175	clavaminate synthase activity
L2I08_RS17445	COG0204	Acyl-transferase
L2I08_RS17450	COG4552	Acetyltransferase involved in intracellular survival and related
L2I08_RS17455	COG0829	nickel cation binding
L2I08_RS17460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L2I08_RS17470	COG0804	urea catabolic process
L2I08_RS17475	COG0832	Belongs to the urease beta subunit family
L2I08_RS17480	COG0831	urea catabolic process
L2I08_RS17490	COG0740	serine-type endopeptidase activity
L2I08_RS17495	COG0791	NLP P60 protein
L2I08_RS17520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L2I08_RS17525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L2I08_RS17530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L2I08_RS17540	COG0488	(ABC) transporter
L2I08_RS17545	COG0488	(ABC) transporter
L2I08_RS17550	COG0456	acetyltransferase
L2I08_RS17570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2I08_RS17575	COG3663	DNA glycosylase
L2I08_RS17590	COG1940	carbohydrate kinase activity
L2I08_RS17595	COG2188	Transcriptional regulator
L2I08_RS17620	COG0626	cystathionine gamma-synthase activity
L2I08_RS17635	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS17645	COG1522	sequence-specific DNA binding
L2I08_RS17650	COG0419	ATPase involved in DNA repair
L2I08_RS17655	COG0420	3'-5' exonuclease activity
L2I08_RS17670	COG1595	DNA-templated transcription, initiation
L2I08_RS17690	COG1739	Uncharacterized protein family UPF0029
L2I08_RS17695	COG1832	CoA-binding protein
L2I08_RS17705	COG0110	maltose O-acetyltransferase activity
L2I08_RS17765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2I08_RS17785	COG1968	undecaprenyl-diphosphatase activity
L2I08_RS17805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L2I08_RS17835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L2I08_RS17875	COG0154	amidase activity
L2I08_RS17885	COG4251	negative regulation of phosphorylation
L2I08_RS17905	COG0697	spore germination
L2I08_RS17920	COG0697	spore germination
L2I08_RS17940	COG0539	negative regulation of cytoplasmic translation
L2I08_RS17980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L2I08_RS17980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L2I08_RS17990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2I08_RS18010	COG1716	ATPase activity
L2I08_RS18030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2I08_RS18060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2I08_RS18070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2I08_RS18090	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L2I08_RS18175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2I08_RS18180	COG2364	Membrane
L2I08_RS18190	COG2270	Major facilitator Superfamily
L2I08_RS18200	COG3030	protein affecting phage T7 exclusion by the F plasmid
L2I08_RS18205	COG0463	Glycosyl transferase, family 2
L2I08_RS18225	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS18255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2I08_RS18260	COG0140	phosphoribosyl-ATP diphosphatase activity
L2I08_RS18265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L2I08_RS18270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2I08_RS18270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2I08_RS18275	COG3201	nicotinamide mononucleotide transporter
L2I08_RS18290	COG1090	epimerase
L2I08_RS18295	COG1940	carbohydrate kinase activity
L2I08_RS18295	COG1846	Transcriptional regulator
L2I08_RS18300	COG0738	Major facilitator superfamily
L2I08_RS18310	COG2233	PERMEase
L2I08_RS18335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2I08_RS18375	COG2390	Transcriptional regulator
L2I08_RS18380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2I08_RS18385	COG2318	DinB family
L2I08_RS18400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L2I08_RS18415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L2I08_RS18425	COG1758	RNA polymerase activity
L2I08_RS18440	COG0284	orotidine-5'-phosphate decarboxylase activity
L2I08_RS18445	COG0167	dihydroorotate dehydrogenase activity
L2I08_RS18450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L2I08_RS18455	COG0505	Belongs to the CarA family
L2I08_RS18465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L2I08_RS18470	COG0540	Belongs to the ATCase OTCase family
L2I08_RS18475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L2I08_RS18485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L2I08_RS18490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L2I08_RS18495	COG0006	proline dipeptidase activity
L2I08_RS18505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L2I08_RS18510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L2I08_RS18515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L2I08_RS18520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L2I08_RS18525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2I08_RS18530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2I08_RS18535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L2I08_RS18550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L2I08_RS18565	COG0124	histidyl-tRNA synthetase
L2I08_RS18575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2I08_RS18580	COG1196	nuclear chromosome segregation
L2I08_RS18590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2I08_RS18600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L2I08_RS18605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2I08_RS18610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2I08_RS18620	COG2255	four-way junction helicase activity
L2I08_RS18625	COG0632	four-way junction helicase activity
L2I08_RS18630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L2I08_RS18635	COG0217	transcriptional regulatory protein
L2I08_RS18640	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L2I08_RS18645	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L2I08_RS18655	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS18660	COG1560	Kdo2-lipid A biosynthetic process
L2I08_RS18665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2I08_RS18680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2I08_RS18685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L2I08_RS18745	COG0456	acetyltransferase
L2I08_RS18820	COG1648	precorrin-2 dehydrogenase activity
L2I08_RS18820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2I08_RS18825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2I08_RS18840	COG1464	Belongs to the NlpA lipoprotein family
L2I08_RS18845	COG1464	Belongs to the NlpA lipoprotein family
L2I08_RS18850	COG2011	ABC-type metal ion transport system permease component
L2I08_RS18855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2I08_RS18860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2I08_RS18885	COG0584	glycerophosphoryl diester phosphodiesterase
L2I08_RS18890	COG0204	Acyl-transferase
L2I08_RS18890	COG0318	PFAM AMP-dependent synthetase and ligase
L2I08_RS18895	COG0477	Major facilitator Superfamily
L2I08_RS18915	COG0165	Argininosuccinate lyase
L2I08_RS18925	COG0385	Bile acid
L2I08_RS18930	COG2409	Drug exporters of the RND superfamily
L2I08_RS18940	COG2197	response regulator
L2I08_RS18945	COG4585	Histidine kinase
L2I08_RS18950	COG1438	arginine binding
L2I08_RS18955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2I08_RS18960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L2I08_RS18965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2I08_RS18970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L2I08_RS19075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L2I08_RS19090	COG1309	transcriptional regulator
L2I08_RS19105	COG2838	Isocitrate dehydrogenase
L2I08_RS19125	COG0477	Major facilitator Superfamily
L2I08_RS19155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2I08_RS19160	COG0697	spore germination
L2I08_RS19190	COG0072	phenylalanine-tRNA ligase activity
L2I08_RS19190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2I08_RS19195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L2I08_RS19200	COG5002	protein histidine kinase activity
L2I08_RS19205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2I08_RS19210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L2I08_RS19215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L2I08_RS19220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L2I08_RS19230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L2I08_RS19265	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS19270	COG0174	glutamine synthetase
L2I08_RS19275	COG2186	Transcriptional regulator
L2I08_RS19280	COG0531	amino acid
L2I08_RS19285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L2I08_RS19310	COG0517	IMP dehydrogenase activity
L2I08_RS19310	COG4175	Glycine betaine
L2I08_RS19315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2I08_RS19325	COG1595	DNA-templated transcription, initiation
L2I08_RS19335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L2I08_RS19345	COG0564	pseudouridine synthase activity
L2I08_RS19375	COG2124	cytochrome p450
L2I08_RS19390	COG0805	protein transport
L2I08_RS19395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2I08_RS19430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L2I08_RS19445	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L2I08_RS19450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L2I08_RS19460	COG4122	O-methyltransferase activity
L2I08_RS19465	COG1222	aaa ATPase
L2I08_RS19485	COG0517	IMP dehydrogenase activity
L2I08_RS19485	COG1994	Peptidase M50
L2I08_RS19495	COG2197	response regulator
L2I08_RS19500	COG0747	negative chemotaxis
L2I08_RS19510	COG1410	methionine synthase
L2I08_RS19510	COG0646	methionine synthase
L2I08_RS19520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L2I08_RS19525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2I08_RS19530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L2I08_RS19545	COG0215	cysteine-tRNA ligase activity
L2I08_RS19565	COG0598	Magnesium transport protein CorA
L2I08_RS19575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS19580	COG0667	Aldo Keto reductase
L2I08_RS19610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2I08_RS19620	COG3189	MarR family transcriptional regulator
L2I08_RS19625	COG3012	SEC-C Motif Domain Protein
L2I08_RS19630	COG2186	Transcriptional regulator
L2I08_RS19635	COG3265	gluconokinase activity
L2I08_RS19675	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L2I08_RS19680	COG2149	membrane
L2I08_RS19700	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS19710	COG0318	PFAM AMP-dependent synthetase and ligase
L2I08_RS19725	COG0488	(ABC) transporter
L2I08_RS19735	COG3876	Protein conserved in bacteria
L2I08_RS19775	COG1309	transcriptional regulator
L2I08_RS19795	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L2I08_RS19800	COG2188	Transcriptional regulator
L2I08_RS19805	COG3973	AAA domain
L2I08_RS19825	COG2755	lipolytic protein G-D-S-L family
L2I08_RS19845	COG1216	Glycosyl transferase, family 2
L2I08_RS19915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2I08_RS19920	COG0587	DNA-directed DNA polymerase activity
L2I08_RS19935	COG0330	HflC and HflK could
L2I08_RS19955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS19960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2I08_RS19970	COG0765	amino acid transport
L2I08_RS19980	COG0765	amino acid transport
L2I08_RS19995	COG1799	cell septum assembly
L2I08_RS20000	COG0477	Major facilitator Superfamily
L2I08_RS20010	COG0671	phosphoesterase, PA-phosphatase related
L2I08_RS20030	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS20050	COG1160	GTP binding
L2I08_RS20060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L2I08_RS20075	COG3541	Predicted nucleotidyltransferase
L2I08_RS20080	COG1397	ADP-ribosylglycohydrolase
L2I08_RS20090	COG1187	pseudouridine synthase activity
L2I08_RS20095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2I08_RS20100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2I08_RS20115	COG0686	Belongs to the AlaDH PNT family
L2I08_RS20125	COG0494	nUDIX hydrolase
L2I08_RS20130	COG0504	CTP synthase activity
L2I08_RS20135	COG3387	PFAM Glycoside hydrolase 15-related
L2I08_RS20145	COG3896	Chloramphenicol phosphotransferase-like protein
L2I08_RS20150	COG0297	glycogen (starch) synthase activity
L2I08_RS20165	COG0497	DNA recombination
L2I08_RS20170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2I08_RS20190	COG0647	UMP catabolic process
L2I08_RS20225	COG2094	Belongs to the DNA glycosylase MPG family
L2I08_RS20235	COG1881	PFAM PEBP family protein
L2I08_RS20255	COG1119	ATPase activity
L2I08_RS20270	COG2197	response regulator
L2I08_RS20285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L2I08_RS20295	COG0842	Transport permease protein
L2I08_RS20295	COG1131	(ABC) transporter
L2I08_RS20295	COG1716	ATPase activity
L2I08_RS20300	COG0560	Phosphoserine phosphatase
L2I08_RS20300	COG3830	Belongs to the UPF0237 family
L2I08_RS20315	COG2807	transmembrane transport
L2I08_RS20320	COG2186	Transcriptional regulator
L2I08_RS20330	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L2I08_RS20340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2I08_RS20345	COG2261	transglycosylase associated protein
L2I08_RS20365	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
L2I08_RS20375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2I08_RS20380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2I08_RS20395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2I08_RS20415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2I08_RS20470	COG0488	(ABC) transporter
L2I08_RS20490	COG0235	Class ii aldolase
L2I08_RS20510	COG1492	cobalamin metabolic process
L2I08_RS20525	COG1797	cobyrinic acid a,c-diamide synthase activity
L2I08_RS20555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2I08_RS20560	COG0456	acetyltransferase
L2I08_RS20570	COG1917	Cupin 2, conserved barrel domain protein
L2I08_RS20575	COG5285	phytanoyl-CoA dioxygenase
L2I08_RS20580	COG1902	pentaerythritol trinitrate reductase activity
L2I08_RS20610	COG4585	Histidine kinase
L2I08_RS20615	COG2197	response regulator
L2I08_RS20650	COG2171	N-acyltransferase activity
L2I08_RS20660	COG0822	iron-sulfur transferase activity
L2I08_RS20665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2I08_RS20670	COG0396	ATPase activity
L2I08_RS20680	COG0719	Fe-S assembly protein
L2I08_RS20695	COG1131	(ABC) transporter
L2I08_RS20705	COG1612	heme a metabolic process
L2I08_RS20720	COG0109	protoheme IX farnesyltransferase activity
L2I08_RS20725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2I08_RS20730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2I08_RS20745	COG0363	glucosamine-6-phosphate deaminase activity
L2I08_RS20750	COG0166	Belongs to the GPI family
L2I08_RS20760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L2I08_RS20765	COG0149	triose-phosphate isomerase activity
L2I08_RS20770	COG0126	phosphoglycerate kinase activity
L2I08_RS20775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2I08_RS20780	COG1481	regulation of sporulation
L2I08_RS20790	COG1660	Displays ATPase and GTPase activities
L2I08_RS20795	COG0322	excinuclease ABC activity
L2I08_RS20810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2I08_RS20820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2I08_RS20825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L2I08_RS20845	COG0556	nucleotide-excision repair
L2I08_RS20855	COG0584	glycerophosphoryl diester phosphodiesterase
L2I08_RS20865	COG0477	Major facilitator Superfamily
L2I08_RS20915	COG1288	antiporter activity
L2I08_RS20940	COG0237	dephospho-CoA kinase activity
L2I08_RS20960	COG2226	methyltransferase
L2I08_RS20965	COG1643	Atp-dependent helicase
L2I08_RS20985	COG2050	protein possibly involved in aromatic compounds catabolism
L2I08_RS20990	COG2746	aminoglycoside 3-N-acetyltransferase activity
L2I08_RS21000	COG0559	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS21040	COG0737	Belongs to the 5'-nucleotidase family
L2I08_RS21045	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L2I08_RS21075	COG0287	Prephenate dehydrogenase
L2I08_RS21075	COG1605	Chorismate mutase
L2I08_RS21085	COG0513	Belongs to the DEAD box helicase family
L2I08_RS21090	COG1278	Cold shock
L2I08_RS21105	COG0069	glutamate synthase activity
L2I08_RS21105	COG0070	glutamate synthase
L2I08_RS21105	COG0067	glutamate synthase
L2I08_RS21115	COG1397	ADP-ribosylglycohydrolase
L2I08_RS21135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2I08_RS21140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2I08_RS21150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L2I08_RS21160	COG0159	tryptophan synthase activity
L2I08_RS21165	COG0133	tryptophan synthase activity
L2I08_RS21170	COG0134	indole-3-glycerol-phosphate synthase activity
L2I08_RS21200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2I08_RS21210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L2I08_RS21215	COG0107	imidazoleglycerol-phosphate synthase activity
L2I08_RS21225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L2I08_RS21230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2I08_RS21240	COG0131	Imidazoleglycerol-phosphate dehydratase
L2I08_RS21245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L2I08_RS21250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2I08_RS21270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2I08_RS21290	COG1432	Conserved Protein
L2I08_RS21300	COG0587	DNA-directed DNA polymerase activity
L2I08_RS21320	COG0515	serine threonine protein kinase
L2I08_RS21335	COG2153	protein acetylation
L2I08_RS21345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L2I08_RS21355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2I08_RS21365	COG3599	regulation of cell shape
L2I08_RS21375	COG1799	cell septum assembly
L2I08_RS21385	COG1496	oxidoreductase activity
L2I08_RS21390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2I08_RS21395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2I08_RS21400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L2I08_RS21410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L2I08_RS21415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2I08_RS21425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2I08_RS21440	COG0275	rRNA processing
L2I08_RS21450	COG0714	Associated with various cellular activities
L2I08_RS21470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2I08_RS21475	COG1121	(ABC) transporter
L2I08_RS21485	COG1309	transcriptional regulator
L2I08_RS21505	COG0352	thiamine-phosphate diphosphorylase activity
L2I08_RS21520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2I08_RS21520	COG2022	thiamine diphosphate biosynthetic process
L2I08_RS21530	COG2022	thiamine diphosphate biosynthetic process
L2I08_RS21535	COG0515	serine threonine protein kinase
L2I08_RS21535	COG2815	serine threonine protein kinase
L2I08_RS21540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L2I08_RS21545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L2I08_RS21550	COG2193	ferroxidase activity
L2I08_RS21555	COG0243	molybdopterin cofactor binding
L2I08_RS21560	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L2I08_RS21570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2I08_RS21575	COG2197	response regulator
L2I08_RS21580	COG4585	Histidine kinase
L2I08_RS21605	COG1940	carbohydrate kinase activity
L2I08_RS21615	COG0003	Pfam Anion-transporting ATPase
L2I08_RS21635	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS21670	COG0705	Rhomboid family
L2I08_RS21685	COG5002	protein histidine kinase activity
L2I08_RS21690	COG0745	RESPONSE REGULATOR receiver
L2I08_RS21700	COG1929	Belongs to the glycerate kinase type-1 family
L2I08_RS21705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2I08_RS21710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2I08_RS21715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L2I08_RS21720	COG0723	plastoquinol--plastocyanin reductase activity
L2I08_RS21725	COG2010	Cytochrome c
L2I08_RS21730	COG1845	cytochrome c oxidase, subunit III
L2I08_RS21740	COG1376	ErfK ybiS ycfS ynhG family protein
L2I08_RS21750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2I08_RS21755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2I08_RS21760	COG1104	cysteine desulfurase activity
L2I08_RS21765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2I08_RS21790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2I08_RS21795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2I08_RS21800	COG2197	response regulator
L2I08_RS21845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2I08_RS21855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L2I08_RS21860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L2I08_RS21865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2I08_RS21870	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2I08_RS21880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L2I08_RS21895	COG4221	oxidoreductase activity
L2I08_RS21920	COG0456	acetyltransferase
L2I08_RS21930	COG0321	lipoyl(octanoyl) transferase activity
L2I08_RS21935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2I08_RS21970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2I08_RS21980	COG2376	Dihydroxyacetone kinase
L2I08_RS21990	COG2326	polyphosphate kinase activity
L2I08_RS22055	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS22085	COG0745	RESPONSE REGULATOR receiver
L2I08_RS22125	COG1309	transcriptional regulator
L2I08_RS22145	COG0366	Alpha amylase catalytic
L2I08_RS22150	COG0395	ABC-type sugar transport system, permease component
L2I08_RS22155	COG1175	transmembrane transport
L2I08_RS22160	COG2182	Extracellular solute-binding protein
L2I08_RS22165	COG1609	Transcriptional regulator
L2I08_RS22180	COG1228	amidohydrolase
L2I08_RS22185	COG0531	amino acid
L2I08_RS22200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2I08_RS22325	COG0174	glutamine synthetase
L2I08_RS22345	COG2132	Multicopper oxidase
L2I08_RS22350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2I08_RS22350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2I08_RS22365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L2I08_RS22370	COG1994	Peptidase M50
L2I08_RS22415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2I08_RS22420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS22425	COG1120	ATPase activity
L2I08_RS22445	COG1834	amidinotransferase
L2I08_RS22455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2I08_RS22460	COG2814	Major facilitator Superfamily
L2I08_RS22470	COG0076	glutamate decarboxylase activity
L2I08_RS22495	COG0384	phenazine biosynthesis protein PhzF
L2I08_RS22500	COG2226	methyltransferase
L2I08_RS22520	COG1733	regulation of RNA biosynthetic process
L2I08_RS22560	COG3022	response to hydroperoxide
L2I08_RS22565	COG0800	Aldolase
L2I08_RS22580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2I08_RS22595	COG1131	(ABC) transporter
L2I08_RS22605	COG4585	Histidine kinase
L2I08_RS22610	COG0346	lactoylglutathione lyase activity
L2I08_RS22615	COG2197	response regulator
L2I08_RS22630	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS22635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2I08_RS22640	COG0477	Major facilitator Superfamily
L2I08_RS22670	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS22690	COG3845	ABC transporter
L2I08_RS22795	COG0586	Pfam SNARE associated Golgi protein
L2I08_RS22810	COG1358	cellular component organization or biogenesis
L2I08_RS22855	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L2I08_RS22875	COG4585	Histidine kinase
L2I08_RS22880	COG2197	response regulator
L2I08_RS22895	COG0667	Aldo Keto reductase
L2I08_RS22900	COG0789	Transcriptional regulator
L2I08_RS22915	COG1741	Belongs to the pirin family
L2I08_RS22930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2I08_RS22935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2I08_RS22940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2I08_RS22970	COG1764	response to oxidative stress
L2I08_RS22975	COG2130	NADP-dependent
L2I08_RS22995	COG1077	Cell shape determining protein MreB Mrl
L2I08_RS23010	COG2890	protein-(glutamine-N5) methyltransferase activity
L2I08_RS23025	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS23030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2I08_RS23050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2I08_RS23075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L2I08_RS23085	COG2851	Citrate transporter
L2I08_RS23090	COG4565	transcriptional regulatory protein
L2I08_RS23095	COG3290	protein histidine kinase activity
L2I08_RS23105	COG0358	DNA primase activity
L2I08_RS23110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L2I08_RS23130	COG1070	Carbohydrate kinase
L2I08_RS23170	COG2226	methyltransferase
L2I08_RS23200	COG0832	Belongs to the urease beta subunit family
L2I08_RS23205	COG0804	urea catabolic process
L2I08_RS23210	COG0830	nickel cation binding
L2I08_RS23215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L2I08_RS23220	COG0829	nickel cation binding
L2I08_RS23230	COG1324	tolerance protein
L2I08_RS23245	COG0574	Belongs to the PEP-utilizing enzyme family
L2I08_RS23245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2I08_RS23255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L2I08_RS23260	COG1846	Transcriptional regulator
L2I08_RS23260	COG1940	carbohydrate kinase activity
L2I08_RS23265	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
L2I08_RS23290	COG3467	pyridoxamine 5'-phosphate
L2I08_RS23300	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L2I08_RS23305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2I08_RS23320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2I08_RS23330	COG0189	ligase activity
L2I08_RS23370	COG0423	glycine-tRNA ligase activity
L2I08_RS23380	COG1121	(ABC) transporter
L2I08_RS23385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2I08_RS23395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2I08_RS23400	COG1381	Involved in DNA repair and RecF pathway recombination
L2I08_RS23415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2I08_RS23430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2I08_RS23440	COG2315	Protein conserved in bacteria
L2I08_RS23450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L2I08_RS23475	COG1486	melibiose metabolic process
L2I08_RS23500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2I08_RS23505	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2I08_RS23525	COG1234	tRNA 3'-trailer cleavage
L2I08_RS23530	COG0537	adenosine 5'-monophosphoramidase activity
L2I08_RS23535	COG0793	Belongs to the peptidase S41A family
L2I08_RS23535	COG4946	Tricorn protease homolog
L2I08_RS23550	COG0484	heat shock protein binding
L2I08_RS23585	COG0481	GTPase activity
L2I08_RS23590	COG0268	Binds directly to 16S ribosomal RNA
L2I08_RS23605	COG2353	YceI-like domain
L2I08_RS23620	COG1555	photosystem II stabilization
L2I08_RS23625	COG1307	EDD domain protein, DegV family
L2I08_RS23635	COG0495	leucyl-tRNA aminoacylation
L2I08_RS23660	COG0588	phosphoglycerate mutase activity
L2I08_RS23665	COG0799	negative regulation of ribosome biogenesis
L2I08_RS23675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L2I08_RS23690	COG0501	Belongs to the peptidase M48B family
L2I08_RS23710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L2I08_RS23720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L2I08_RS23740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L2I08_RS23745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L2I08_RS23750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L2I08_RS23755	COG1530	ribonuclease E activity
L2I08_RS23780	COG0772	Belongs to the SEDS family
L2I08_RS23800	COG1077	Cell shape determining protein MreB Mrl
L2I08_RS23805	COG0105	UTP biosynthetic process
L2I08_RS23815	COG0285	dihydrofolate synthase activity
L2I08_RS23820	COG0525	valine-tRNA ligase activity
L2I08_RS23830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L2I08_RS23835	COG0740	serine-type endopeptidase activity
L2I08_RS23840	COG0740	serine-type endopeptidase activity
L2I08_RS23845	COG0544	peptidyl-prolyl cis-trans isomerase activity
L2I08_RS23865	COG3594	Acyltransferase
L2I08_RS23870	COG0475	glutathione-regulated potassium exporter activity
L2I08_RS23880	COG4552	Acetyltransferase involved in intracellular survival and related
L2I08_RS23895	COG1113	amino acid transport
L2I08_RS23900	COG1268	BioY protein
L2I08_RS23905	COG1113	amino acid transport
L2I08_RS23910	COG1113	amino acid transport
L2I08_RS23915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2I08_RS23920	COG0076	glutamate decarboxylase activity
L2I08_RS23925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2I08_RS23960	COG4266	Belongs to the allantoicase family
L2I08_RS23990	COG0583	DNA-binding transcription factor activity
L2I08_RS24010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L2I08_RS24025	COG0668	transmembrane transport
L2I08_RS24035	COG1486	melibiose metabolic process
L2I08_RS24060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2I08_RS24090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2I08_RS24095	COG0667	Aldo Keto reductase
L2I08_RS24115	COG1136	(ABC) transporter
L2I08_RS24185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2I08_RS24225	COG3629	intracellular signal transduction
L2I08_RS24225	COG3903	Transcriptional regulator
L2I08_RS24260	COG1131	(ABC) transporter
L2I08_RS24275	COG3962	Belongs to the TPP enzyme family
L2I08_RS24280	COG3718	enzyme involved in inositol metabolism
L2I08_RS24325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2I08_RS24330	COG1472	Belongs to the glycosyl hydrolase 3 family
L2I08_RS24350	COG3960	tartronate-semialdehyde synthase activity
L2I08_RS24385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2I08_RS24410	COG1011	Hydrolase
L2I08_RS24430	COG1946	Acyl-CoA thioesterase
L2I08_RS24440	COG1309	transcriptional regulator
L2I08_RS24445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2I08_RS24460	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS24510	COG3655	Transcriptional regulator
L2I08_RS24520	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS24550	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L2I08_RS24575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2I08_RS24590	COG4977	sequence-specific DNA binding
L2I08_RS24595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2I08_RS24650	COG2985	domain, Protein
L2I08_RS24665	COG0745	RESPONSE REGULATOR receiver
L2I08_RS24690	COG0406	alpha-ribazole phosphatase activity
L2I08_RS24725	COG0709	Synthesizes selenophosphate from selenide and ATP
L2I08_RS24755	COG0012	GTP binding
L2I08_RS24770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L2I08_RS24775	COG0531	amino acid
L2I08_RS24780	COG1570	exodeoxyribonuclease VII activity
L2I08_RS24785	COG1722	exodeoxyribonuclease VII activity
L2I08_RS24790	COG0778	Nitroreductase
L2I08_RS24815	COG0515	serine threonine protein kinase
L2I08_RS24825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2I08_RS24825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2I08_RS24835	COG0114	fumarate hydratase activity
L2I08_RS24845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2I08_RS24860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2I08_RS24880	COG1136	(ABC) transporter
L2I08_RS24890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2I08_RS24895	COG0450	alkyl hydroperoxide reductase
L2I08_RS24915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L2I08_RS24920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2I08_RS24925	COG0667	Aldo Keto reductase
L2I08_RS24935	COG3548	integral membrane protein
L2I08_RS24945	COG2304	oxidoreductase activity
L2I08_RS24950	COG0656	L-ascorbic acid biosynthetic process
L2I08_RS24955	COG2814	Major facilitator Superfamily
L2I08_RS25020	COG2894	cell division
L2I08_RS25055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2I08_RS25125	COG0251	oxidation-reduction process
L2I08_RS25130	COG1414	Transcriptional regulator
L2I08_RS25145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
L2I08_RS25175	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L2I08_RS25195	COG1331	Highly conserved protein containing a thioredoxin domain
L2I08_RS25205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2I08_RS25240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L2I08_RS25275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L2I08_RS25285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2I08_RS25300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2I08_RS25305	COG2255	four-way junction helicase activity
L2I08_RS25330	COG2318	DinB family
L2I08_RS25335	COG1064	alcohol dehydrogenase
L2I08_RS25340	COG1136	(ABC) transporter
L2I08_RS25360	COG2986	histidine ammonia-lyase
L2I08_RS25370	COG1024	Enoyl-CoA hydratase
L2I08_RS25375	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L2I08_RS25385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2I08_RS25400	COG0424	maF-like protein
L2I08_RS25410	COG4770	biotin carboxylase activity
L2I08_RS25450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2I08_RS25470	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS25515	COG1595	DNA-templated transcription, initiation
L2I08_RS25520	COG0745	RESPONSE REGULATOR receiver
L2I08_RS25525	COG2205	protein histidine kinase activity
L2I08_RS25550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2I08_RS25575	COG0583	DNA-binding transcription factor activity
L2I08_RS25580	COG2814	Major facilitator Superfamily
L2I08_RS25620	COG1079	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS25625	COG4603	Belongs to the binding-protein-dependent transport system permease family
L2I08_RS25630	COG3845	ABC transporter
L2I08_RS25635	COG1744	ABC transporter substrate-binding protein PnrA-like
L2I08_RS25665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2I08_RS25680	COG1473	amidohydrolase
L2I08_RS25680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L2I08_RS25690	COG2089	acid synthase
L2I08_RS25695	COG1083	cytidylyl-transferase
L2I08_RS25705	COG1216	Glycosyl transferase, family 2
L2I08_RS25775	COG1595	DNA-templated transcription, initiation
L2I08_RS25780	COG1215	transferase activity, transferring glycosyl groups
L2I08_RS25820	COG2009	succinate dehydrogenase
L2I08_RS25830	COG1053	succinate dehydrogenase
L2I08_RS25835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2I08_RS25850	COG1309	transcriptional regulator
L2I08_RS25870	COG1408	metallophosphoesterase
L2I08_RS25885	COG1295	ribonuclease BN
L2I08_RS25930	COG0180	Tryptophanyl-tRNA synthetase
L2I08_RS25965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2I08_RS25975	COG0754	glutathionylspermidine amidase activity
L2I08_RS25985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2I08_RS25990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2I08_RS26000	COG1609	Transcriptional regulator
L2I08_RS26005	COG2362	D-Aminopeptidase
L2I08_RS26025	COG1175	transmembrane transport
L2I08_RS26030	COG0395	ABC-type sugar transport system, permease component
L2I08_RS26060	COG0517	IMP dehydrogenase activity
L2I08_RS26060	COG4175	Glycine betaine
L2I08_RS26070	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS26090	COG0039	L-malate dehydrogenase activity
L2I08_RS26110	COG2197	response regulator
L2I08_RS26125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L2I08_RS26135	COG0138	bifunctional purine biosynthesis protein purh
L2I08_RS26165	COG0045	succinate-CoA ligase (ADP-forming) activity
L2I08_RS26170	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L2I08_RS26175	COG2425	protein containing a von Willebrand factor type A (vWA) domain
L2I08_RS26180	COG0714	Associated with various cellular activities
L2I08_RS26195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L2I08_RS26195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L2I08_RS26200	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L2I08_RS26205	COG1196	nuclear chromosome segregation
L2I08_RS26205	COG0741	lytic transglycosylase activity
L2I08_RS26205	COG0739	heme binding
L2I08_RS26210	COG2066	Belongs to the glutaminase family
L2I08_RS26250	COG0791	NLP P60 protein
L2I08_RS26270	COG1228	amidohydrolase
L2I08_RS26280	COG0456	acetyltransferase
L2I08_RS26280	COG1846	Transcriptional regulator
L2I08_RS26325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2I08_RS26330	COG2197	response regulator
L2I08_RS26370	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS26380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2I08_RS26380	COG0519	Catalyzes the synthesis of GMP from XMP
L2I08_RS26400	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS26440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L2I08_RS26450	COG0516	GMP reductase activity
L2I08_RS26460	COG1595	DNA-templated transcription, initiation
L2I08_RS26465	COG2197	response regulator
L2I08_RS26475	COG0583	DNA-binding transcription factor activity
L2I08_RS26480	COG4221	oxidoreductase activity
L2I08_RS26495	COG0726	polysaccharide deacetylase
L2I08_RS26530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L2I08_RS26555	COG0802	atpase or kinase
L2I08_RS26565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2I08_RS26630	COG0736	holo-[acyl-carrier-protein] synthase activity
L2I08_RS26645	COG4977	sequence-specific DNA binding
L2I08_RS26660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2I08_RS26675	COG1072	(Pantothenic acid kinase))
L2I08_RS26680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2I08_RS26685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2I08_RS26690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L2I08_RS26700	COG0101	tRNA pseudouridine synthase activity
L2I08_RS26705	COG0203	ribosomal protein L17
L2I08_RS26715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L2I08_RS26720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L2I08_RS26725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L2I08_RS26730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L2I08_RS26740	COG0563	adenylate kinase activity
L2I08_RS26745	COG0201	protein transport
L2I08_RS26750	COG0200	Binds to the 23S rRNA
L2I08_RS26755	COG1841	ribosomal large subunit assembly
L2I08_RS26760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L2I08_RS26765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L2I08_RS26770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L2I08_RS26775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L2I08_RS26780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L2I08_RS26785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L2I08_RS26790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L2I08_RS26795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L2I08_RS26800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L2I08_RS26805	COG0255	Belongs to the universal ribosomal protein uL29 family
L2I08_RS26810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L2I08_RS26815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L2I08_RS26820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L2I08_RS26825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L2I08_RS26830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L2I08_RS26835	COG0089	rRNA binding
L2I08_RS26840	COG0088	Forms part of the polypeptide exit tunnel
L2I08_RS26845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L2I08_RS26850	COG0051	transcription antitermination factor activity, RNA binding
L2I08_RS26860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L2I08_RS26880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2I08_RS26885	COG0049	tRNA binding
L2I08_RS26890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L2I08_RS26925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L2I08_RS26930	COG0085	RNA polymerase activity
L2I08_RS26935	COG0222	ribosome binding
L2I08_RS26940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L2I08_RS26950	COG0081	regulation of translation
L2I08_RS26975	COG0436	Aminotransferase
L2I08_RS26980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2I08_RS26990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L2I08_RS27000	COG2030	dehydratase
L2I08_RS27005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2I08_RS27020	COG0402	S-adenosylhomocysteine deaminase activity
L2I08_RS27025	COG0702	epimerase
L2I08_RS27040	COG1666	GTP binding
L2I08_RS27045	COG2261	transglycosylase associated protein
L2I08_RS27050	COG3304	Inner membrane component domain
L2I08_RS27055	COG0501	Belongs to the peptidase M48B family
L2I08_RS27060	COG1007	ATP synthesis coupled electron transport
L2I08_RS27070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2I08_RS27075	COG0713	ATP synthesis coupled electron transport
L2I08_RS27080	COG0839	Belongs to the complex I subunit 6 family
L2I08_RS27085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS27090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L2I08_RS27095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS27100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS27105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS27115	COG4585	Histidine kinase
L2I08_RS27120	COG2197	response regulator
L2I08_RS27125	COG0674	pyruvate-flavodoxin oxidoreductase activity
L2I08_RS27125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L2I08_RS27130	COG1013	pyruvate-flavodoxin oxidoreductase activity
L2I08_RS27135	COG1733	regulation of RNA biosynthetic process
L2I08_RS27140	COG0702	epimerase
L2I08_RS27150	COG0488	(ABC) transporter
L2I08_RS27185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2I08_RS27205	COG0142	geranyltranstransferase activity
L2I08_RS27210	COG3104	oligopeptide transport
L2I08_RS27225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L2I08_RS27235	COG0561	phosphatase activity
L2I08_RS27255	COG0514	ATP-dependent DNA helicase (RecQ)
L2I08_RS27260	COG1007	ATP synthesis coupled electron transport
L2I08_RS27270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2I08_RS27275	COG0713	ATP synthesis coupled electron transport
L2I08_RS27280	COG0839	Belongs to the complex I subunit 6 family
L2I08_RS27285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS27290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L2I08_RS27295	COG1034	ATP synthesis coupled electron transport
L2I08_RS27300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2I08_RS27310	COG0649	NAD binding
L2I08_RS27315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS27320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2I08_RS27345	COG2226	methyltransferase
L2I08_RS27355	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L2I08_RS27405	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
L2I08_RS27530	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L2I08_RS27535	COG1278	Cold shock
L2I08_RS27545	COG0183	Belongs to the thiolase family
L2I08_RS27580	COG3559	Exporter of polyketide antibiotics
L2I08_RS27585	COG1131	(ABC) transporter
L2I08_RS27600	COG1301	dicarboxylic acid transport
L2I08_RS27615	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L2I08_RS27630	COG0163	prenyltransferase activity
L2I08_RS27635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2I08_RS27640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L2I08_RS27655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L2I08_RS27665	COG0785	Cytochrome C biogenesis protein
L2I08_RS27670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2I08_RS27680	COG0406	alpha-ribazole phosphatase activity
L2I08_RS27685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L2I08_RS27735	COG0659	secondary active sulfate transmembrane transporter activity
L2I08_RS27740	COG1690	Belongs to the RtcB family
L2I08_RS27765	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
L2I08_RS27770	COG0018	arginyl-trna synthetase
L2I08_RS27775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2I08_RS27795	COG0113	porphobilinogen synthase activity
L2I08_RS27800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2I08_RS27800	COG1648	precorrin-2 dehydrogenase activity
L2I08_RS27805	COG0181	hydroxymethylbilane synthase activity
L2I08_RS27810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L2I08_RS27815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L2I08_RS27875	COG0123	including yeast histone deacetylase and acetoin utilization protein
L2I08_RS27905	COG0180	Tryptophanyl-tRNA synthetase
L2I08_RS27910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L2I08_RS27920	COG0842	Transport permease protein
L2I08_RS27920	COG1129	ABC transporter
L2I08_RS27940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2I08_RS27950	COG0129	dihydroxy-acid dehydratase activity
L2I08_RS27955	COG1309	transcriptional regulator
L2I08_RS27960	COG1082	Xylose isomerase domain protein TIM barrel
L2I08_RS27970	COG0248	Ppx GppA phosphatase
L2I08_RS28005	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
L2I08_RS28015	COG0671	phosphoesterase, PA-phosphatase related
L2I08_RS28025	COG1595	DNA-templated transcription, initiation
L2I08_RS28035	COG0745	RESPONSE REGULATOR receiver
L2I08_RS28040	COG2205	protein histidine kinase activity
L2I08_RS28045	COG0739	heme binding
L2I08_RS28070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L2I08_RS28090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L2I08_RS28100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L2I08_RS28105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L2I08_RS28120	COG2197	response regulator
L2I08_RS28135	COG0649	NAD binding
L2I08_RS28155	COG2197	response regulator
L2I08_RS28160	COG4585	Histidine kinase
L2I08_RS28180	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS28245	COG0477	Major facilitator Superfamily
L2I08_RS28260	COG0477	Major facilitator Superfamily
L2I08_RS28270	COG1732	Glycine betaine
L2I08_RS28275	COG1174	glycine betaine transport
L2I08_RS28280	COG1174	glycine betaine transport
L2I08_RS28285	COG1125	glycine betaine transport
L2I08_RS28285	COG0517	IMP dehydrogenase activity
L2I08_RS28300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L2I08_RS28305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2I08_RS28315	COG0302	gtp cyclohydrolase
L2I08_RS28330	COG0037	tRNA processing
L2I08_RS28340	COG2027	D-alanyl-D-alanine carboxypeptidase
L2I08_RS28345	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2I08_RS28355	COG0586	Pfam SNARE associated Golgi protein
L2I08_RS28360	COG0789	Transcriptional regulator
L2I08_RS28365	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2I08_RS28375	COG2318	DinB family
L2I08_RS28380	COG1012	belongs to the aldehyde dehydrogenase family
L2I08_RS28405	COG1289	transmembrane transporter activity
L2I08_RS28430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L2I08_RS28450	COG0501	Belongs to the peptidase M48B family
L2I08_RS28480	COG2186	Transcriptional regulator
L2I08_RS28485	COG2828	Protein conserved in bacteria
L2I08_RS28490	COG2159	amidohydrolase
L2I08_RS28505	COG2814	Major facilitator Superfamily
L2I08_RS28505	COG0477	Major facilitator Superfamily
L2I08_RS28520	COG0739	heme binding
L2I08_RS28535	COG2186	Transcriptional regulator
L2I08_RS28540	COG0588	phosphoglycerate mutase activity
L2I08_RS28565	COG0438	transferase activity, transferring glycosyl groups
L2I08_RS28575	COG3103	Sh3 type 3 domain protein
L2I08_RS28575	COG1388	LysM domain
L2I08_RS28575	COG0791	NLP P60 protein
L2I08_RS28600	COG1309	transcriptional regulator
L2I08_RS28620	COG2226	methyltransferase
L2I08_RS28630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2I08_RS28650	COG2226	methyltransferase
L2I08_RS28690	COG1476	TRANSCRIPTIONal
L2I08_RS28710	COG0789	Transcriptional regulator
L2I08_RS28725	COG1490	D-aminoacyl-tRNA deacylase activity
L2I08_RS28730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L2I08_RS28735	COG0735	belongs to the Fur family
L2I08_RS28740	COG3485	protocatechuate 3,4-dioxygenase
L2I08_RS28775	COG2897	thiosulfate sulfurtransferase activity
L2I08_RS28800	COG0745	RESPONSE REGULATOR receiver
L2I08_RS28805	COG1609	Transcriptional regulator
L2I08_RS28815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2I08_RS28820	COG0745	RESPONSE REGULATOR receiver
L2I08_RS28835	COG4214	carbohydrate transport
L2I08_RS28840	COG1129	ABC transporter
L2I08_RS28850	COG1609	Transcriptional regulator
L2I08_RS28860	COG2160	L-arabinose isomerase activity
L2I08_RS28865	COG0235	Class ii aldolase
L2I08_RS28870	COG0737	Belongs to the 5'-nucleotidase family
L2I08_RS28875	COG0456	acetyltransferase
L2I08_RS28940	COG4941	Belongs to the sigma-70 factor family
L2I08_RS28945	COG1725	Transcriptional regulator
L2I08_RS28955	COG1131	(ABC) transporter
L2I08_RS28970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L2I08_RS28995	COG2267	carboxylic ester hydrolase activity
L2I08_RS29050	COG1595	DNA-templated transcription, initiation
L2I08_RS29090	COG3629	intracellular signal transduction
L2I08_RS29090	COG3903	Transcriptional regulator
L2I08_RS29095	COG0596	Alpha beta hydrolase
L2I08_RS29105	COG2208	phosphoserine phosphatase activity
L2I08_RS29105	COG2770	Histidine kinase
L2I08_RS29155	COG2318	DinB family
L2I08_RS29160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2I08_RS29170	COG0494	nUDIX hydrolase
L2I08_RS29190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2I08_RS29195	COG0306	phosphate transporter
L2I08_RS29205	COG1937	Protein conserved in bacteria
L2I08_RS29215	COG1028	Short-chain dehydrogenase reductase Sdr
L2I08_RS29230	COG0671	phosphoesterase, PA-phosphatase related
L2I08_RS29235	COG0741	lytic transglycosylase activity
L2I08_RS29235	COG0739	heme binding
L2I08_RS29235	COG1196	nuclear chromosome segregation
L2I08_RS29260	COG2318	DinB family
L2I08_RS29270	COG0509	glycine decarboxylation via glycine cleavage system
L2I08_RS29325	COG0477	Major facilitator Superfamily
L2I08_RS29330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L2I08_RS29335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L2I08_RS29340	COG2124	cytochrome p450
L2I08_RS29345	COG2267	carboxylic ester hydrolase activity
L2I08_RS29360	COG0798	PFAM Bile acid sodium symporter
L2I08_RS29365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2I08_RS29380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2I08_RS29395	COG1335	isochorismatase
L2I08_RS29405	COG2197	response regulator
L2I08_RS29410	COG4585	Histidine kinase
L2I08_RS29415	COG0702	epimerase
L2I08_RS29425	COG3844	kynureninase activity
L2I08_RS29445	COG0477	Major facilitator Superfamily
L2I08_RS29450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L2I08_RS29455	COG0191	fructose-bisphosphate aldolase activity
L2I08_RS29460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L2I08_RS29475	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L2I08_RS29500	COG2378	regulation of single-species biofilm formation
L2I08_RS29515	COG0477	Major facilitator Superfamily
L2I08_RS29540	COG0789	Transcriptional regulator
L2I08_RS29545	COG0484	heat shock protein binding
L2I08_RS29550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L2I08_RS29555	COG0443	Heat shock 70 kDa protein
L2I08_RS29590	COG1725	Transcriptional regulator
L2I08_RS29595	COG1131	(ABC) transporter
L2I08_RS29605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2I08_RS29625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L2I08_RS29630	COG1404	Belongs to the peptidase S8 family
L2I08_RS29635	COG1120	ATPase activity
L2I08_RS29640	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS29645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2I08_RS29685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2I08_RS29685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2I08_RS29715	COG1695	Transcriptional regulator
L2I08_RS29725	COG2814	Major facilitator Superfamily
L2I08_RS29735	COG3629	intracellular signal transduction
L2I08_RS29735	COG3903	Transcriptional regulator
L2I08_RS29765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2I08_RS29775	COG0717	Belongs to the dCTP deaminase family
L2I08_RS29805	COG0247	lactate metabolic process
L2I08_RS29805	COG2181	nitrate reductase activity
L2I08_RS29810	COG0657	acetylesterase activity
L2I08_RS29835	COG0477	Major facilitator Superfamily
L2I08_RS29855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2I08_RS29890	COG1064	alcohol dehydrogenase
L2I08_RS29895	COG1937	Protein conserved in bacteria
L2I08_RS29900	COG2268	Band 7 protein
L2I08_RS29915	COG1316	TRANSCRIPTIONal
L2I08_RS29955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2I08_RS29965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L2I08_RS29975	COG0628	permease
L2I08_RS29980	COG1741	Belongs to the pirin family
L2I08_RS29990	COG1960	acyl-CoA dehydrogenase activity
L2I08_RS30010	COG1362	aminopeptidase activity
L2I08_RS30070	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2I08_RS30075	COG0022	dehydrogenase e1 component
L2I08_RS30090	COG0515	serine threonine protein kinase
L2I08_RS30095	COG0515	serine threonine protein kinase
L2I08_RS30120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2I08_RS30125	COG0303	'Molybdopterin
L2I08_RS30130	COG0746	molybdenum cofactor guanylyltransferase activity
L2I08_RS30150	COG1522	sequence-specific DNA binding
L2I08_RS30190	COG1733	regulation of RNA biosynthetic process
L2I08_RS30195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2I08_RS30205	COG1716	ATPase activity
L2I08_RS30210	COG1716	ATPase activity
L2I08_RS30230	COG0515	serine threonine protein kinase
L2I08_RS30235	COG3764	Sortase (surface protein transpeptidase)
L2I08_RS30240	COG3764	Sortase (surface protein transpeptidase)
L2I08_RS30260	COG0705	Rhomboid family
L2I08_RS30280	COG1309	transcriptional regulator
L2I08_RS30300	COG0515	serine threonine protein kinase
L2I08_RS30340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L2I08_RS30345	COG0187	DNA topoisomerase II activity
L2I08_RS30350	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
L2I08_RS30355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2I08_RS30360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L2I08_RS30365	COG0592	DNA-directed DNA polymerase activity
L2I08_RS30370	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L2I08_RS30375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L2I08_RS30380	COG0594	ribonuclease P activity
L2I08_RS30385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L2I08_RS30390	COG0706	membrane insertase activity
L2I08_RS30400	COG0357	Ribosomal RNA small subunit methyltransferase G
L2I08_RS30405	COG1192	Involved in chromosome partitioning
L2I08_RS30420	COG3118	belongs to the thioredoxin family
L2I08_RS30425	COG0492	ferredoxin-NADP+ reductase activity
L2I08_RS30435	COG1595	DNA-templated transcription, initiation
L2I08_RS30440	COG2815	serine threonine protein kinase
L2I08_RS30440	COG0515	serine threonine protein kinase
L2I08_RS30455	COG0617	tRNA 3'-terminal CCA addition
L2I08_RS30480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2I08_RS30505	COG0360	Binds together with S18 to 16S ribosomal RNA
L2I08_RS30510	COG0629	single-stranded DNA binding
L2I08_RS30515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L2I08_RS30520	COG0359	binds to the 23S rRNA
L2I08_RS30530	COG0305	Participates in initiation and elongation during chromosome replication
L2I08_RS30535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2I08_RS30540	COG0110	maltose O-acetyltransferase activity
L2I08_RS30585	COG0626	cystathionine gamma-synthase activity
L2I08_RS30590	COG1950	PFAM Membrane protein of
L2I08_RS30595	COG0662	Cupin 2, conserved barrel domain protein
L2I08_RS30620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L2I08_RS30635	COG1609	Transcriptional regulator
L2I08_RS30640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L2I08_RS30645	COG1271	oxidase subunit
L2I08_RS30650	COG1294	oxidase, subunit
L2I08_RS30655	COG4988	ABC transporter
L2I08_RS30665	COG1196	nuclear chromosome segregation
L2I08_RS30665	COG0739	heme binding
L2I08_RS30665	COG0741	lytic transglycosylase activity
L2I08_RS30670	COG0561	phosphatase activity
L2I08_RS30690	COG1131	(ABC) transporter
L2I08_RS30710	COG0561	phosphatase activity
L2I08_RS30715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L2I08_RS30720	COG0077	Prephenate dehydratase
L2I08_RS30725	COG2837	iron assimilation
L2I08_RS30740	COG1999	signal sequence binding
L2I08_RS30900	COG2186	Transcriptional regulator
L2I08_RS31115	COG1475	DNA binding
L2I08_RS31120	COG1192	Involved in chromosome partitioning
L2I08_RS31200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2I08_RS31210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2I08_RS31220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2I08_RS31235	COG1006	Multisubunit Na H antiporter MnhC subunit
L2I08_RS31295	COG0629	single-stranded DNA binding