locus-tag	class	description
HZZ00_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZZ00_RS00010	COG0592	DNA-directed DNA polymerase activity
HZZ00_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZZ00_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZZ00_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HZZ00_RS00030	COG0187	DNA topoisomerase II activity
HZZ00_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZZ00_RS00065	COG2319	Wd-40 repeat
HZZ00_RS00065	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_RS00095	COG0515	serine threonine protein kinase
HZZ00_RS00135	COG0705	Rhomboid family
HZZ00_RS00160	COG3764	Sortase (surface protein transpeptidase)
HZZ00_RS00165	COG3764	Sortase (surface protein transpeptidase)
HZZ00_RS00170	COG0515	serine threonine protein kinase
HZZ00_RS00190	COG1716	ATPase activity
HZZ00_RS00195	COG1716	ATPase activity
HZZ00_RS00205	COG0477	Major facilitator Superfamily
HZZ00_RS00230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_RS00235	COG2151	metal-sulfur cluster biosynthetic enzyme
HZZ00_RS00240	COG3396	Phenylacetate-CoA oxygenase
HZZ00_RS00245	COG3460	Phenylacetate-CoA oxygenase
HZZ00_RS00250	COG3396	Phenylacetate-CoA oxygenase
HZZ00_RS00275	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS00280	COG1309	transcriptional regulator
HZZ00_RS00285	COG1522	sequence-specific DNA binding
HZZ00_RS00315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZZ00_RS00320	COG3321	synthase
HZZ00_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS00320	COG0604	alcohol dehydrogenase
HZZ00_RS00335	COG0515	serine threonine protein kinase
HZZ00_RS00340	COG0515	serine threonine protein kinase
HZZ00_RS00355	COG0022	dehydrogenase e1 component
HZZ00_RS00360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_RS00430	COG2271	Major facilitator Superfamily
HZZ00_RS00465	COG1362	aminopeptidase activity
HZZ00_RS00470	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS00480	COG1741	Belongs to the pirin family
HZZ00_RS00495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZZ00_RS00505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZZ00_RS00515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZZ00_RS00520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_RS00545	COG1473	amidohydrolase
HZZ00_RS00565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZZ00_RS00570	COG1957	nucleoside hydrolase
HZZ00_RS00575	COG0366	Alpha amylase catalytic
HZZ00_RS00590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZZ00_RS00640	COG0701	Predicted permease
HZZ00_RS00665	COG2188	Transcriptional regulator
HZZ00_RS00675	COG1595	DNA-templated transcription, initiation
HZZ00_RS00680	COG1252	NADH dehydrogenase
HZZ00_RS00700	COG0640	Transcriptional regulator
HZZ00_RS00705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZZ00_RS00725	COG1902	pentaerythritol trinitrate reductase activity
HZZ00_RS00735	COG0714	Associated with various cellular activities
HZZ00_RS00750	COG1278	Cold shock
HZZ00_RS00770	COG0513	Belongs to the DEAD box helicase family
HZZ00_RS00775	COG1278	Cold shock
HZZ00_RS00800	COG0038	chloride channel
HZZ00_RS00805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_RS00805	COG0515	serine threonine protein kinase
HZZ00_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS00820	COG1309	transcriptional regulator
HZZ00_RS00830	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS00840	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HZZ00_RS00855	COG0717	Belongs to the dCTP deaminase family
HZZ00_RS00860	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HZZ00_RS00880	COG2181	nitrate reductase activity
HZZ00_RS00880	COG0247	lactate metabolic process
HZZ00_RS00885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZZ00_RS00890	COG0443	Heat shock 70 kDa protein
HZZ00_RS00895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZZ00_RS00900	COG0484	heat shock protein binding
HZZ00_RS00905	COG0789	Transcriptional regulator
HZZ00_RS00910	COG4213	ABC transporter substrate-binding protein
HZZ00_RS00945	COG0542	response to heat
HZZ00_RS00970	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZZ00_RS00985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZZ00_RS00995	COG0477	Major facilitator Superfamily
HZZ00_RS01010	COG3844	kynureninase activity
HZZ00_RS01030	COG4585	Histidine kinase
HZZ00_RS01035	COG2197	response regulator
HZZ00_RS01040	COG4585	Histidine kinase
HZZ00_RS01045	COG2197	response regulator
HZZ00_RS01060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZZ00_RS01065	COG0737	Belongs to the 5'-nucleotidase family
HZZ00_RS01075	COG1802	Transcriptional regulator
HZZ00_RS01085	COG0515	serine threonine protein kinase
HZZ00_RS01085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_RS01100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZZ00_RS01105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZZ00_RS01125	COG1595	DNA-templated transcription, initiation
HZZ00_RS01150	COG0791	NLP P60 protein
HZZ00_RS01150	COG3883	PFAM NLP P60 protein
HZZ00_RS01160	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS01190	COG0588	phosphoglycerate mutase activity
HZZ00_RS01200	COG2188	Transcriptional regulator
HZZ00_RS01235	COG5002	protein histidine kinase activity
HZZ00_RS01250	COG1329	Transcriptional regulator
HZZ00_RS01255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZZ00_RS01260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZZ00_RS01270	COG0215	cysteine-tRNA ligase activity
HZZ00_RS01285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZZ00_RS01295	COG3842	ATPase activity
HZZ00_RS01315	COG0667	Aldo Keto reductase
HZZ00_RS01335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_RS01340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_RS01350	COG0583	DNA-binding transcription factor activity
HZZ00_RS01355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_RS01365	COG0662	Cupin 2, conserved barrel domain protein
HZZ00_RS01375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_RS01380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_RS01385	COG2867	negative regulation of translational initiation
HZZ00_RS01410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_RS01410	COG0723	plastoquinol--plastocyanin reductase activity
HZZ00_RS01450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZZ00_RS01470	COG3300	MHYT domain
HZZ00_RS01470	COG5001	Diguanylate cyclase
HZZ00_RS01515	COG0463	Glycosyl transferase, family 2
HZZ00_RS01530	COG1278	Cold shock
HZZ00_RS01535	COG0459	protein refolding
HZZ00_RS01550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZZ00_RS01555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZZ00_RS01560	COG1737	Transcriptional regulator
HZZ00_RS01595	COG2268	Band 7 protein
HZZ00_RS01605	COG3973	AAA domain
HZZ00_RS01645	COG1278	Cold shock
HZZ00_RS01650	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HZZ00_RS01655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZZ00_RS01665	COG2814	Major facilitator Superfamily
HZZ00_RS01695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZZ00_RS01705	COG2252	PERMEase
HZZ00_RS01735	COG0667	Aldo Keto reductase
HZZ00_RS01750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZZ00_RS01755	COG0277	FAD linked oxidase domain protein
HZZ00_RS01755	COG0247	lactate metabolic process
HZZ00_RS01765	COG5006	permease, DMT superfamily
HZZ00_RS01785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_RS01805	COG1309	transcriptional regulator
HZZ00_RS01820	COG0259	pyridoxamine-phosphate oxidase activity
HZZ00_RS01835	COG4821	SIS domain
HZZ00_RS01845	COG2945	thiolester hydrolase activity
HZZ00_RS01845	COG0596	Alpha beta hydrolase
HZZ00_RS01925	COG2072	flavoprotein involved in K transport
HZZ00_RS01935	COG0259	pyridoxamine-phosphate oxidase activity
HZZ00_RS01940	COG1280	lysine exporter protein (LysE YggA)
HZZ00_RS01945	COG1522	sequence-specific DNA binding
HZZ00_RS01960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_RS01960	COG0515	serine threonine protein kinase
HZZ00_RS01970	COG3903	Transcriptional regulator
HZZ00_RS01970	COG3629	intracellular signal transduction
HZZ00_RS02010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HZZ00_RS02045	COG3903	Transcriptional regulator
HZZ00_RS02045	COG3629	intracellular signal transduction
HZZ00_RS02070	COG1686	Belongs to the peptidase S11 family
HZZ00_RS02095	COG0386	Belongs to the glutathione peroxidase family
HZZ00_RS02120	COG0326	Molecular chaperone. Has ATPase activity
HZZ00_RS02135	COG0589	response to stress
HZZ00_RS02170	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZZ00_RS02210	COG0477	Major facilitator Superfamily
HZZ00_RS02230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZZ00_RS02265	COG0366	Alpha amylase catalytic
HZZ00_RS02270	COG0366	Alpha amylase catalytic
HZZ00_RS02290	COG1309	transcriptional regulator
HZZ00_RS02310	COG1846	Transcriptional regulator
HZZ00_RS02315	COG3384	dioxygenase
HZZ00_RS02320	COG1247	-acetyltransferase
HZZ00_RS02350	COG1376	ErfK ybiS ycfS ynhG family protein
HZZ00_RS02370	COG1970	mechanosensitive ion channel activity
HZZ00_RS02380	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZZ00_RS02400	COG2366	antibiotic biosynthetic process
HZZ00_RS02405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZZ00_RS02410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZZ00_RS02420	COG0315	cyclic pyranopterin monophosphate synthase activity
HZZ00_RS02425	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZZ00_RS02425	COG0315	cyclic pyranopterin monophosphate synthase activity
HZZ00_RS02430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_RS02445	COG0454	-acetyltransferase
HZZ00_RS02460	COG2072	flavoprotein involved in K transport
HZZ00_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS02480	COG4946	Tricorn protease homolog
HZZ00_RS02480	COG0793	Belongs to the peptidase S41A family
HZZ00_RS02490	COG2409	Drug exporters of the RND superfamily
HZZ00_RS02495	COG0442	prolyl-tRNA aminoacylation
HZZ00_RS02515	COG1122	ATPase activity
HZZ00_RS02525	COG0310	cobalt ion transport
HZZ00_RS02575	COG0084	hydrolase, TatD family'
HZZ00_RS02585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZZ00_RS02590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZZ00_RS02595	COG0488	(ABC) transporter
HZZ00_RS02635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZZ00_RS02645	COG2197	response regulator
HZZ00_RS02655	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_RS02665	COG1309	transcriptional regulator
HZZ00_RS02675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZZ00_RS02685	COG0193	aminoacyl-tRNA hydrolase activity
HZZ00_RS02690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZZ00_RS02695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZZ00_RS02700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZZ00_RS02710	COG4585	Histidine kinase
HZZ00_RS02740	COG1136	(ABC) transporter
HZZ00_RS02745	COG1136	(ABC) transporter
HZZ00_RS02745	COG0577	efflux transmembrane transporter activity
HZZ00_RS02805	COG2124	cytochrome p450
HZZ00_RS02820	COG0148	phosphopyruvate hydratase activity
HZZ00_RS02840	COG1252	NADH dehydrogenase
HZZ00_RS02845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZZ00_RS02850	COG0577	efflux transmembrane transporter activity
HZZ00_RS02855	COG1136	(ABC) transporter
HZZ00_RS02855	COG0577	efflux transmembrane transporter activity
HZZ00_RS02885	COG0183	Belongs to the thiolase family
HZZ00_RS02890	COG2755	lipolytic protein G-D-S-L family
HZZ00_RS02955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZZ00_RS02970	COG1228	amidohydrolase
HZZ00_RS02975	COG1191	sigma factor activity
HZZ00_RS02980	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_RS02990	COG3104	oligopeptide transport
HZZ00_RS02995	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS03000	COG2205	protein histidine kinase activity
HZZ00_RS03040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZZ00_RS03055	COG3415	Transposase
HZZ00_RS03055	COG2801	Transposase and inactivated derivatives
HZZ00_RS03060	COG1316	TRANSCRIPTIONal
HZZ00_RS03065	COG1607	acyl-coa hydrolase
HZZ00_RS03070	COG1316	TRANSCRIPTIONal
HZZ00_RS03080	COG1316	TRANSCRIPTIONal
HZZ00_RS03085	COG1316	TRANSCRIPTIONal
HZZ00_RS03110	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HZZ00_RS03110	COG0778	Nitroreductase
HZZ00_RS03115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZZ00_RS03155	COG2835	tetraacyldisaccharide 4'-kinase activity
HZZ00_RS03165	COG1482	cell wall glycoprotein biosynthetic process
HZZ00_RS03175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZZ00_RS03215	COG0714	Associated with various cellular activities
HZZ00_RS03235	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZZ00_RS03240	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS03245	COG5002	protein histidine kinase activity
HZZ00_RS03245	COG5000	phosphorelay sensor kinase activity
HZZ00_RS03250	COG0823	Involved in the tonB-independent uptake of proteins
HZZ00_RS03260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZZ00_RS03265	COG2197	response regulator
HZZ00_RS03270	COG3214	Protein conserved in bacteria
HZZ00_RS03280	COG0653	protein targeting
HZZ00_RS03305	COG2902	Dehydrogenase
HZZ00_RS03315	COG1215	transferase activity, transferring glycosyl groups
HZZ00_RS03320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZZ00_RS03325	COG1134	teichoic acid transport
HZZ00_RS03325	COG1388	LysM domain
HZZ00_RS03350	COG1215	transferase activity, transferring glycosyl groups
HZZ00_RS03365	COG1846	Transcriptional regulator
HZZ00_RS03370	COG1764	response to oxidative stress
HZZ00_RS03375	COG1216	Glycosyl transferase, family 2
HZZ00_RS03380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZZ00_RS03385	COG1216	Glycosyl transferase, family 2
HZZ00_RS03390	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS03395	COG1175	transmembrane transport
HZZ00_RS03400	COG1653	transport
HZZ00_RS03405	COG1674	ftsk spoiiie
HZZ00_RS03410	COG0515	serine threonine protein kinase
HZZ00_RS03415	COG0515	serine threonine protein kinase
HZZ00_RS03420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZZ00_RS03435	COG2884	Cell division ATP-binding protein ftsE
HZZ00_RS03440	COG2177	Part of the ABC transporter FtsEX involved in
HZZ00_RS03445	COG0793	Belongs to the peptidase S41A family
HZZ00_RS03450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZZ00_RS03465	COG2264	protein methyltransferase activity
HZZ00_RS03475	COG3973	AAA domain
HZZ00_RS03485	COG0776	regulation of translation
HZZ00_RS03490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZZ00_RS03495	COG1678	Uncharacterized ACR, COG1678
HZZ00_RS03505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZZ00_RS03565	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HZZ00_RS03575	COG0277	FAD linked oxidase domain protein
HZZ00_RS03610	COG1335	isochorismatase
HZZ00_RS03620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HZZ00_RS03630	COG1113	amino acid transport
HZZ00_RS03665	COG1234	tRNA 3'-trailer cleavage
HZZ00_RS03670	COG1263	PTS System
HZZ00_RS03675	COG1263	PTS System
HZZ00_RS03680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZZ00_RS03685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZZ00_RS03700	COG4555	ABC transporter
HZZ00_RS03715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_RS03745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZZ00_RS03755	COG2733	membrane
HZZ00_RS03765	COG1733	regulation of RNA biosynthetic process
HZZ00_RS03775	COG0071	Belongs to the small heat shock protein (HSP20) family
HZZ00_RS03785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZZ00_RS03880	COG0477	Major facilitator Superfamily
HZZ00_RS03895	COG0706	membrane insertase activity
HZZ00_RS03910	COG4702	Belongs to the UPF0303 family
HZZ00_RS03915	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS03920	COG1940	carbohydrate kinase activity
HZZ00_RS03940	COG2188	Transcriptional regulator
HZZ00_RS04005	COG3397	chitin binding
HZZ00_RS04020	COG1126	abc transporter atp-binding protein
HZZ00_RS04025	COG0765	amino acid transport
HZZ00_RS04030	COG0765	amino acid transport
HZZ00_RS04035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_RS04040	COG0154	amidase activity
HZZ00_RS04055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS04110	COG0406	alpha-ribazole phosphatase activity
HZZ00_RS04125	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZZ00_RS04135	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS04145	COG3979	chitinase
HZZ00_RS04170	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS04190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZZ00_RS04195	COG4977	sequence-specific DNA binding
HZZ00_RS04205	COG0589	response to stress
HZZ00_RS04210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZZ00_RS04240	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HZZ00_RS04250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZZ00_RS04290	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS04305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_RS04310	COG1309	transcriptional regulator
HZZ00_RS04320	COG1946	Acyl-CoA thioesterase
HZZ00_RS04340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_RS04350	COG0028	Belongs to the TPP enzyme family
HZZ00_RS04390	COG1472	Belongs to the glycosyl hydrolase 3 family
HZZ00_RS04410	COG1609	Transcriptional regulator
HZZ00_RS04430	COG2207	Transcriptional regulator
HZZ00_RS04460	COG4941	Belongs to the sigma-70 factor family
HZZ00_RS04470	COG1869	D-ribose catabolic process
HZZ00_RS04475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS04485	COG1129	ABC transporter
HZZ00_RS04500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZZ00_RS04535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS04545	COG3718	enzyme involved in inositol metabolism
HZZ00_RS04550	COG3962	Belongs to the TPP enzyme family
HZZ00_RS04565	COG1131	(ABC) transporter
HZZ00_RS04640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZZ00_RS04645	COG2815	serine threonine protein kinase
HZZ00_RS04645	COG0515	serine threonine protein kinase
HZZ00_RS04665	COG2318	DinB family
HZZ00_RS04670	COG1733	regulation of RNA biosynthetic process
HZZ00_RS04675	COG0667	Aldo Keto reductase
HZZ00_RS04695	COG0629	single-stranded DNA binding
HZZ00_RS04735	COG1136	(ABC) transporter
HZZ00_RS04755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZZ00_RS04785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_RS04805	COG1486	melibiose metabolic process
HZZ00_RS04810	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS04815	COG1175	transmembrane transport
HZZ00_RS04825	COG1940	carbohydrate kinase activity
HZZ00_RS04835	COG0668	transmembrane transport
HZZ00_RS04850	COG1136	(ABC) transporter
HZZ00_RS04895	COG2226	methyltransferase
HZZ00_RS04925	COG3415	Transposase
HZZ00_RS04925	COG2801	Transposase and inactivated derivatives
HZZ00_RS04950	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HZZ00_RS04960	COG0588	phosphoglycerate mutase activity
HZZ00_RS04965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZZ00_RS04970	COG1113	amino acid transport
HZZ00_RS04985	COG1116	anion transmembrane transporter activity
HZZ00_RS04990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZZ00_RS05000	COG1940	carbohydrate kinase activity
HZZ00_RS05010	COG1113	amino acid transport
HZZ00_RS05025	COG4552	Acetyltransferase involved in intracellular survival and related
HZZ00_RS05040	COG3594	Acyltransferase
HZZ00_RS05085	COG2188	Transcriptional regulator
HZZ00_RS05105	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZZ00_RS05110	COG0740	serine-type endopeptidase activity
HZZ00_RS05115	COG0740	serine-type endopeptidase activity
HZZ00_RS05120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZZ00_RS05130	COG0525	valine-tRNA ligase activity
HZZ00_RS05135	COG0285	dihydrofolate synthase activity
HZZ00_RS05145	COG0105	UTP biosynthetic process
HZZ00_RS05150	COG1077	Cell shape determining protein MreB Mrl
HZZ00_RS05165	COG0768	penicillin binding
HZZ00_RS05170	COG0772	Belongs to the SEDS family
HZZ00_RS05190	COG1530	ribonuclease E activity
HZZ00_RS05195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZZ00_RS05200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZZ00_RS05205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZZ00_RS05220	COG1215	transferase activity, transferring glycosyl groups
HZZ00_RS05230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZZ00_RS05240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZZ00_RS05255	COG0501	Belongs to the peptidase M48B family
HZZ00_RS05270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZZ00_RS05280	COG0799	negative regulation of ribosome biogenesis
HZZ00_RS05285	COG0588	phosphoglycerate mutase activity
HZZ00_RS05305	COG0495	leucyl-tRNA aminoacylation
HZZ00_RS05315	COG1307	EDD domain protein, DegV family
HZZ00_RS05320	COG1555	photosystem II stabilization
HZZ00_RS05335	COG2353	YceI-like domain
HZZ00_RS05350	COG0268	Binds directly to 16S ribosomal RNA
HZZ00_RS05355	COG0481	GTPase activity
HZZ00_RS05360	COG1022	Amp-dependent synthetase and ligase
HZZ00_RS05385	COG1420	regulation of RNA biosynthetic process
HZZ00_RS05390	COG0484	heat shock protein binding
HZZ00_RS05415	COG4946	Tricorn protease homolog
HZZ00_RS05415	COG0793	Belongs to the peptidase S41A family
HZZ00_RS05420	COG0537	adenosine 5'-monophosphoramidase activity
HZZ00_RS05425	COG1234	tRNA 3'-trailer cleavage
HZZ00_RS05430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_RS05445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZZ00_RS05455	COG2315	Protein conserved in bacteria
HZZ00_RS05460	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZZ00_RS05480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZZ00_RS05515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZZ00_RS05585	COG1381	Involved in DNA repair and RecF pathway recombination
HZZ00_RS05590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZZ00_RS05600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZZ00_RS05605	COG1120	ATPase activity
HZZ00_RS05610	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZZ00_RS05610	COG3443	Belongs to the bacterial solute-binding protein 9 family
HZZ00_RS05615	COG0423	glycine-tRNA ligase activity
HZZ00_RS05630	COG0667	Aldo Keto reductase
HZZ00_RS05635	COG1309	transcriptional regulator
HZZ00_RS05645	COG0477	Major facilitator Superfamily
HZZ00_RS05680	COG1940	carbohydrate kinase activity
HZZ00_RS05680	COG1846	Transcriptional regulator
HZZ00_RS05685	COG0574	Belongs to the PEP-utilizing enzyme family
HZZ00_RS05685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZZ00_RS05705	COG1653	transport
HZZ00_RS05710	COG1175	transmembrane transport
HZZ00_RS05715	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS05750	COG4555	ABC transporter
HZZ00_RS05780	COG3458	cephalosporin-C deacetylase activity
HZZ00_RS05790	COG2258	MOSC domain
HZZ00_RS05800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZZ00_RS05815	COG2949	membrane
HZZ00_RS05820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZZ00_RS05830	COG0358	DNA primase activity
HZZ00_RS05835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZZ00_RS05850	COG1070	Carbohydrate kinase
HZZ00_RS05900	COG1077	Cell shape determining protein MreB Mrl
HZZ00_RS05925	COG1404	Belongs to the peptidase S8 family
HZZ00_RS05930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZZ00_RS05930	COG0825	malonyl-CoA metabolic process
HZZ00_RS05935	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS05975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_RS05980	COG2130	NADP-dependent
HZZ00_RS06005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_RS06015	COG0156	8-amino-7-oxononanoate synthase activity
HZZ00_RS06070	COG1764	response to oxidative stress
HZZ00_RS06075	COG2130	NADP-dependent
HZZ00_RS06095	COG1335	isochorismatase
HZZ00_RS06100	COG1335	isochorismatase
HZZ00_RS06125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_RS06130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_RS06135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_RS06165	COG0789	Transcriptional regulator
HZZ00_RS06170	COG0667	Aldo Keto reductase
HZZ00_RS06185	COG1309	transcriptional regulator
HZZ00_RS06190	COG0477	Major facilitator Superfamily
HZZ00_RS06195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HZZ00_RS06240	COG1358	cellular component organization or biogenesis
HZZ00_RS06255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_RS06300	COG3973	AAA domain
HZZ00_RS06330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZZ00_RS06370	COG4122	O-methyltransferase activity
HZZ00_RS06380	COG0477	Major facilitator Superfamily
HZZ00_RS06385	COG0477	Major facilitator Superfamily
HZZ00_RS06395	COG3619	membrane
HZZ00_RS06415	COG3845	ABC transporter
HZZ00_RS06470	COG1309	transcriptional regulator
HZZ00_RS06475	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS06500	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZZ00_RS06510	COG0477	Major facilitator Superfamily
HZZ00_RS06520	COG2197	response regulator
HZZ00_RS06530	COG4585	Histidine kinase
HZZ00_RS06540	COG1131	(ABC) transporter
HZZ00_RS06545	COG2030	dehydratase
HZZ00_RS06560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZZ00_RS06575	COG0800	Aldolase
HZZ00_RS06580	COG3022	response to hydroperoxide
HZZ00_RS06630	COG2259	Doxx family
HZZ00_RS06650	COG2814	Major facilitator Superfamily
HZZ00_RS06655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZZ00_RS06675	COG0672	)-iron permease
HZZ00_RS06680	COG2837	iron assimilation
HZZ00_RS06695	COG0384	phenazine biosynthesis protein PhzF
HZZ00_RS06730	COG1994	Peptidase M50
HZZ00_RS06755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZZ00_RS06760	COG0477	Major facilitator Superfamily
HZZ00_RS06775	COG2814	Major facilitator Superfamily
HZZ00_RS06845	COG1959	2 iron, 2 sulfur cluster binding
HZZ00_RS06850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_RS06850	COG1017	nitric oxide dioxygenase activity
HZZ00_RS06855	COG0174	glutamine synthetase
HZZ00_RS06860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZZ00_RS06895	COG3511	phospholipase C
HZZ00_RS06910	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZZ00_RS06920	COG1609	Transcriptional regulator
HZZ00_RS06930	COG1175	transmembrane transport
HZZ00_RS06935	COG3833	ABC-type maltose transport systems, permease component
HZZ00_RS06940	COG0366	Alpha amylase catalytic
HZZ00_RS06980	COG2197	response regulator
HZZ00_RS06995	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS07030	COG0501	Belongs to the peptidase M48B family
HZZ00_RS07045	COG0174	glutamine synthetase
HZZ00_RS07065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZZ00_RS07070	COG0321	lipoyl(octanoyl) transferase activity
HZZ00_RS07110	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HZZ00_RS07120	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_RS07125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZZ00_RS07130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZZ00_RS07135	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HZZ00_RS07155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZZ00_RS07175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZZ00_RS07200	COG4585	Histidine kinase
HZZ00_RS07205	COG2197	response regulator
HZZ00_RS07210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZZ00_RS07215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZZ00_RS07235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS07245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZZ00_RS07250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_RS07260	COG1376	ErfK ybiS ycfS ynhG family protein
HZZ00_RS07270	COG1845	cytochrome c oxidase, subunit III
HZZ00_RS07275	COG2010	Cytochrome c
HZZ00_RS07280	COG0723	plastoquinol--plastocyanin reductase activity
HZZ00_RS07285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZZ00_RS07290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZZ00_RS07295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZZ00_RS07325	COG0791	NLP P60 protein
HZZ00_RS07325	COG0741	lytic transglycosylase activity
HZZ00_RS07340	COG0534	Mate efflux family protein
HZZ00_RS07350	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS07370	COG0003	Pfam Anion-transporting ATPase
HZZ00_RS07380	COG1940	carbohydrate kinase activity
HZZ00_RS07405	COG4585	Histidine kinase
HZZ00_RS07415	COG0205	6-phosphofructokinase activity
HZZ00_RS07430	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HZZ00_RS07440	COG2193	ferroxidase activity
HZZ00_RS07445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZZ00_RS07450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HZZ00_RS07455	COG0515	serine threonine protein kinase
HZZ00_RS07455	COG2815	serine threonine protein kinase
HZZ00_RS07460	COG2022	thiamine diphosphate biosynthetic process
HZZ00_RS07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_RS07470	COG2022	thiamine diphosphate biosynthetic process
HZZ00_RS07490	COG0352	thiamine-phosphate diphosphorylase activity
HZZ00_RS07515	COG1309	transcriptional regulator
HZZ00_RS07555	COG0714	Associated with various cellular activities
HZZ00_RS07565	COG0275	rRNA processing
HZZ00_RS07575	COG0768	penicillin binding
HZZ00_RS07580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZZ00_RS07590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZZ00_RS07595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZZ00_RS07605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZZ00_RS07615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZZ00_RS07630	COG1799	cell septum assembly
HZZ00_RS07640	COG3599	regulation of cell shape
HZZ00_RS07645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZZ00_RS07655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZZ00_RS07665	COG2153	protein acetylation
HZZ00_RS07710	COG0587	DNA-directed DNA polymerase activity
HZZ00_RS07720	COG1432	Conserved Protein
HZZ00_RS07740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZZ00_RS07760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZZ00_RS07765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZZ00_RS07770	COG0131	Imidazoleglycerol-phosphate dehydratase
HZZ00_RS07780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZZ00_RS07785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZZ00_RS07790	COG0251	oxidation-reduction process
HZZ00_RS07795	COG0107	imidazoleglycerol-phosphate synthase activity
HZZ00_RS07810	COG0346	lactoylglutathione lyase activity
HZZ00_RS07820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZZ00_RS07850	COG0134	indole-3-glycerol-phosphate synthase activity
HZZ00_RS07855	COG0133	tryptophan synthase activity
HZZ00_RS07860	COG0159	tryptophan synthase activity
HZZ00_RS07870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZZ00_RS07875	COG2301	Belongs to the HpcH HpaI aldolase family
HZZ00_RS07880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_RS07885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS07905	COG1397	ADP-ribosylglycohydrolase
HZZ00_RS07915	COG0070	glutamate synthase
HZZ00_RS07915	COG0069	glutamate synthase activity
HZZ00_RS07915	COG0067	glutamate synthase
HZZ00_RS07945	COG0287	Prephenate dehydrogenase
HZZ00_RS07945	COG1605	Chorismate mutase
HZZ00_RS08010	COG0683	leucine binding
HZZ00_RS08015	COG2050	protein possibly involved in aromatic compounds catabolism
HZZ00_RS08040	COG1643	Atp-dependent helicase
HZZ00_RS08050	COG0539	negative regulation of cytoplasmic translation
HZZ00_RS08065	COG0237	dephospho-CoA kinase activity
HZZ00_RS08080	COG2226	methyltransferase
HZZ00_RS08160	COG0598	Magnesium transport protein CorA
HZZ00_RS08165	COG2226	methyltransferase
HZZ00_RS08170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZZ00_RS08170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZZ00_RS08175	COG2313	pseudouridylate synthase activity
HZZ00_RS08180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZZ00_RS08185	COG0584	glycerophosphoryl diester phosphodiesterase
HZZ00_RS08195	COG0556	nucleotide-excision repair
HZZ00_RS08215	COG0387	Pfam Sodium calcium exchanger
HZZ00_RS08220	COG0477	Major facilitator Superfamily
HZZ00_RS08225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZZ00_RS08230	COG1126	abc transporter atp-binding protein
HZZ00_RS08235	COG0765	amino acid transport
HZZ00_RS08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_RS08245	COG1733	regulation of RNA biosynthetic process
HZZ00_RS08250	COG3321	synthase
HZZ00_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS08250	COG0604	alcohol dehydrogenase
HZZ00_RS08260	COG0583	DNA-binding transcription factor activity
HZZ00_RS08275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZZ00_RS08285	COG1609	Transcriptional regulator
HZZ00_RS08300	COG0322	excinuclease ABC activity
HZZ00_RS08305	COG1660	Displays ATPase and GTPase activities
HZZ00_RS08310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZZ00_RS08315	COG1481	regulation of sporulation
HZZ00_RS08320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZZ00_RS08325	COG0126	phosphoglycerate kinase activity
HZZ00_RS08330	COG0149	triose-phosphate isomerase activity
HZZ00_RS08335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZZ00_RS08345	COG0166	Belongs to the GPI family
HZZ00_RS08355	COG0363	glucosamine-6-phosphate deaminase activity
HZZ00_RS08370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZZ00_RS08380	COG0109	protoheme IX farnesyltransferase activity
HZZ00_RS08395	COG1612	heme a metabolic process
HZZ00_RS08405	COG1131	(ABC) transporter
HZZ00_RS08410	COG2746	aminoglycoside 3-N-acetyltransferase activity
HZZ00_RS08425	COG0719	Fe-S assembly protein
HZZ00_RS08435	COG0396	ATPase activity
HZZ00_RS08440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZZ00_RS08445	COG0822	iron-sulfur transferase activity
HZZ00_RS08455	COG2076	Multidrug Resistance protein
HZZ00_RS08460	COG3226	Transcriptional regulator
HZZ00_RS08465	COG2171	N-acyltransferase activity
HZZ00_RS08475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_RS08535	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS08555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_RS08585	COG1414	Transcriptional regulator
HZZ00_RS08605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZZ00_RS08610	COG5285	phytanoyl-CoA dioxygenase
HZZ00_RS08615	COG1917	Cupin 2, conserved barrel domain protein
HZZ00_RS08620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZZ00_RS08625	COG0456	acetyltransferase
HZZ00_RS08630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZZ00_RS08700	COG1797	cobyrinic acid a,c-diamide synthase activity
HZZ00_RS08720	COG1492	cobalamin metabolic process
HZZ00_RS08725	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HZZ00_RS08745	COG0235	Class ii aldolase
HZZ00_RS08765	COG0488	(ABC) transporter
HZZ00_RS08775	COG1024	Enoyl-CoA hydratase
HZZ00_RS08815	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_RS08830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZZ00_RS08840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_RS08845	COG1404	Belongs to the peptidase S8 family
HZZ00_RS08855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_RS08860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZZ00_RS08875	COG2261	transglycosylase associated protein
HZZ00_RS08880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZZ00_RS08910	COG2186	Transcriptional regulator
HZZ00_RS08925	COG0588	phosphoglycerate mutase activity
HZZ00_RS08930	COG0560	Phosphoserine phosphatase
HZZ00_RS08930	COG3830	Belongs to the UPF0237 family
HZZ00_RS08935	COG1716	ATPase activity
HZZ00_RS08935	COG1131	(ABC) transporter
HZZ00_RS08935	COG0842	Transport permease protein
HZZ00_RS08945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZZ00_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS08960	COG2197	response regulator
HZZ00_RS08975	COG1119	ATPase activity
HZZ00_RS08995	COG1881	PFAM PEBP family protein
HZZ00_RS09005	COG2094	Belongs to the DNA glycosylase MPG family
HZZ00_RS09035	COG0647	UMP catabolic process
HZZ00_RS09040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZZ00_RS09045	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZZ00_RS09050	COG1120	ATPase activity
HZZ00_RS09070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZZ00_RS09075	COG2801	Transposase and inactivated derivatives
HZZ00_RS09075	COG3415	Transposase
HZZ00_RS09080	COG0497	DNA recombination
HZZ00_RS09090	COG0297	glycogen (starch) synthase activity
HZZ00_RS09105	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_RS09110	COG0504	CTP synthase activity
HZZ00_RS09115	COG0494	nUDIX hydrolase
HZZ00_RS09125	COG0686	Belongs to the AlaDH PNT family
HZZ00_RS09140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZZ00_RS09145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZZ00_RS09150	COG1187	pseudouridine synthase activity
HZZ00_RS09155	COG1397	ADP-ribosylglycohydrolase
HZZ00_RS09160	COG3541	Predicted nucleotidyltransferase
HZZ00_RS09185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZZ00_RS09195	COG1160	GTP binding
HZZ00_RS09210	COG1652	LysM domain
HZZ00_RS09220	COG0671	phosphoesterase, PA-phosphatase related
HZZ00_RS09230	COG0477	Major facilitator Superfamily
HZZ00_RS09235	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS09240	COG1799	cell septum assembly
HZZ00_RS09250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_RS09255	COG0765	amino acid transport
HZZ00_RS09265	COG1126	abc transporter atp-binding protein
HZZ00_RS09285	COG0587	DNA-directed DNA polymerase activity
HZZ00_RS09310	COG2264	protein methyltransferase activity
HZZ00_RS09325	COG1725	Transcriptional regulator
HZZ00_RS09345	COG2755	lipolytic protein G-D-S-L family
HZZ00_RS09355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_RS09380	COG2188	Transcriptional regulator
HZZ00_RS09385	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HZZ00_RS09395	COG1309	transcriptional regulator
HZZ00_RS09420	COG0640	Transcriptional regulator
HZZ00_RS09430	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS09480	COG3876	Protein conserved in bacteria
HZZ00_RS09490	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS09500	COG0583	DNA-binding transcription factor activity
HZZ00_RS09515	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HZZ00_RS09545	COG3265	gluconokinase activity
HZZ00_RS09550	COG2186	Transcriptional regulator
HZZ00_RS09555	COG3012	SEC-C Motif Domain Protein
HZZ00_RS09580	COG1796	DNA polymerase
HZZ00_RS09580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZZ00_RS09620	COG0667	Aldo Keto reductase
HZZ00_RS09625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS09635	COG0598	Magnesium transport protein CorA
HZZ00_RS09640	COG0406	alpha-ribazole phosphatase activity
HZZ00_RS09655	COG0215	cysteine-tRNA ligase activity
HZZ00_RS09665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZZ00_RS09670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZZ00_RS09675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZZ00_RS09680	COG1414	Transcriptional regulator
HZZ00_RS09685	COG0646	methionine synthase
HZZ00_RS09685	COG1410	methionine synthase
HZZ00_RS09695	COG0747	negative chemotaxis
HZZ00_RS09700	COG2197	response regulator
HZZ00_RS09710	COG1994	Peptidase M50
HZZ00_RS09710	COG0517	IMP dehydrogenase activity
HZZ00_RS09730	COG1222	aaa ATPase
HZZ00_RS09735	COG4122	O-methyltransferase activity
HZZ00_RS09750	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_RS09755	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_RS09760	COG1609	Transcriptional regulator
HZZ00_RS09770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_RS09810	COG0805	protein transport
HZZ00_RS09845	COG0564	pseudouridine synthase activity
HZZ00_RS09855	COG3903	Transcriptional regulator
HZZ00_RS09855	COG3629	intracellular signal transduction
HZZ00_RS09865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZZ00_RS09870	COG0517	IMP dehydrogenase activity
HZZ00_RS09870	COG4175	Glycine betaine
HZZ00_RS09875	COG4176	ABC-type proline glycine betaine transport system permease component
HZZ00_RS09885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZZ00_RS09900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZZ00_RS09905	COG2186	Transcriptional regulator
HZZ00_RS09910	COG0174	glutamine synthetase
HZZ00_RS09915	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS09950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZZ00_RS09955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZZ00_RS09960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZZ00_RS09965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZZ00_RS09970	COG5002	protein histidine kinase activity
HZZ00_RS09975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZZ00_RS09980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZZ00_RS09980	COG0072	phenylalanine-tRNA ligase activity
HZZ00_RS09995	COG1051	belongs to the nudix hydrolase family
HZZ00_RS10015	COG0604	alcohol dehydrogenase
HZZ00_RS10025	COG1649	PFAM Uncharacterised BCR, COG1649
HZZ00_RS10055	COG0463	Glycosyl transferase, family 2
HZZ00_RS10065	COG3903	Transcriptional regulator
HZZ00_RS10065	COG2197	response regulator
HZZ00_RS10070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HZZ00_RS10085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZZ00_RS10090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZZ00_RS10095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZZ00_RS10100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_RS10105	COG1438	arginine binding
HZZ00_RS10120	COG1132	(ABC) transporter
HZZ00_RS10130	COG1477	protein flavinylation
HZZ00_RS10140	COG1017	nitric oxide dioxygenase activity
HZZ00_RS10140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_RS10145	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS10150	COG2205	protein histidine kinase activity
HZZ00_RS10165	COG0137	argininosuccinate synthase activity
HZZ00_RS10170	COG0165	Argininosuccinate lyase
HZZ00_RS10180	COG4977	sequence-specific DNA binding
HZZ00_RS10195	COG0477	Major facilitator Superfamily
HZZ00_RS10200	COG2132	Multicopper oxidase
HZZ00_RS10205	COG0204	Acyl-transferase
HZZ00_RS10205	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS10235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZZ00_RS10240	COG2011	ABC-type metal ion transport system permease component
HZZ00_RS10245	COG1464	Belongs to the NlpA lipoprotein family
HZZ00_RS10260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZZ00_RS10265	COG1648	precorrin-2 dehydrogenase activity
HZZ00_RS10265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZZ00_RS10320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZZ00_RS10380	COG2176	DNA-directed DNA polymerase activity
HZZ00_RS10380	COG5002	protein histidine kinase activity
HZZ00_RS10395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZZ00_RS10415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZZ00_RS10420	COG1560	Kdo2-lipid A biosynthetic process
HZZ00_RS10425	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS10435	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HZZ00_RS10440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HZZ00_RS10445	COG0217	transcriptional regulatory protein
HZZ00_RS10450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZZ00_RS10455	COG0632	four-way junction helicase activity
HZZ00_RS10460	COG2255	four-way junction helicase activity
HZZ00_RS10470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZZ00_RS10475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZZ00_RS10480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZZ00_RS10485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZZ00_RS10490	COG1196	nuclear chromosome segregation
HZZ00_RS10495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZZ00_RS10505	COG0124	histidyl-tRNA synthetase
HZZ00_RS10520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZZ00_RS10540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZZ00_RS10545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZZ00_RS10555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZZ00_RS10560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZZ00_RS10565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZZ00_RS10570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZZ00_RS10580	COG0006	proline dipeptidase activity
HZZ00_RS10585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZZ00_RS10590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZZ00_RS10600	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZZ00_RS10605	COG0540	Belongs to the ATCase OTCase family
HZZ00_RS10610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZZ00_RS10620	COG0505	Belongs to the CarA family
HZZ00_RS10625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZZ00_RS10630	COG0167	dihydroorotate dehydrogenase activity
HZZ00_RS10635	COG0284	orotidine-5'-phosphate decarboxylase activity
HZZ00_RS10645	COG0194	GDP metabolic process
HZZ00_RS10660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZZ00_RS10680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZZ00_RS10690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZZ00_RS10695	COG2390	Transcriptional regulator
HZZ00_RS10720	COG0531	amino acid
HZZ00_RS10730	COG2188	Transcriptional regulator
HZZ00_RS10755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZZ00_RS10775	COG2233	PERMEase
HZZ00_RS10785	COG0738	Major facilitator superfamily
HZZ00_RS10790	COG1940	carbohydrate kinase activity
HZZ00_RS10790	COG1846	Transcriptional regulator
HZZ00_RS10800	COG3201	nicotinamide mononucleotide transporter
HZZ00_RS10805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZZ00_RS10805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZZ00_RS10810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZZ00_RS10815	COG0140	phosphoribosyl-ATP diphosphatase activity
HZZ00_RS10820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZZ00_RS11090	COG1660	Displays ATPase and GTPase activities
HZZ00_RS11285	COG1216	Glycosyl transferase, family 2
HZZ00_RS11290	COG3030	protein affecting phage T7 exclusion by the F plasmid
HZZ00_RS11305	COG2270	Major facilitator Superfamily
HZZ00_RS11315	COG2364	Membrane
HZZ00_RS11345	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS11350	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS11360	COG1984	allophanate hydrolase subunit 2
HZZ00_RS11365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HZZ00_RS11370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HZZ00_RS11375	COG4336	lyase activity
HZZ00_RS11380	COG2814	Major facilitator Superfamily
HZZ00_RS11405	COG1414	Transcriptional regulator
HZZ00_RS11420	COG2018	Roadblock/LC7 domain
HZZ00_RS11455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_RS11465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZZ00_RS11495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZZ00_RS11515	COG1716	ATPase activity
HZZ00_RS11535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZZ00_RS11545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZZ00_RS11545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZZ00_RS11650	COG0697	spore germination
HZZ00_RS11685	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS11690	COG0747	negative chemotaxis
HZZ00_RS11695	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZZ00_RS11710	COG2318	DinB family
HZZ00_RS11715	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS11720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HZZ00_RS11745	COG0183	Belongs to the thiolase family
HZZ00_RS11760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZZ00_RS11805	COG0110	maltose O-acetyltransferase activity
HZZ00_RS11815	COG1396	sequence-specific DNA binding
HZZ00_RS11815	COG1917	Cupin 2, conserved barrel domain protein
HZZ00_RS11830	COG0640	Transcriptional regulator
HZZ00_RS11835	COG0531	amino acid
HZZ00_RS11840	COG1832	CoA-binding protein
HZZ00_RS11855	COG1739	Uncharacterized protein family UPF0029
HZZ00_RS11860	COG0420	3'-5' exonuclease activity
HZZ00_RS11865	COG0419	ATPase involved in DNA repair
HZZ00_RS11875	COG2124	cytochrome p450
HZZ00_RS11900	COG0626	cystathionine gamma-synthase activity
HZZ00_RS11915	COG0596	Alpha beta hydrolase
HZZ00_RS11925	COG1595	DNA-templated transcription, initiation
HZZ00_RS11930	COG2188	Transcriptional regulator
HZZ00_RS11935	COG1940	carbohydrate kinase activity
HZZ00_RS11950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZZ00_RS11970	COG0028	Belongs to the TPP enzyme family
HZZ00_RS11990	COG0456	acetyltransferase
HZZ00_RS12005	COG1136	(ABC) transporter
HZZ00_RS12005	COG0577	efflux transmembrane transporter activity
HZZ00_RS12020	COG2226	methyltransferase
HZZ00_RS12025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZZ00_RS12030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZZ00_RS12035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZZ00_RS12070	COG0740	serine-type endopeptidase activity
HZZ00_RS12090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_RS12095	COG1834	amidinotransferase
HZZ00_RS12100	COG1522	sequence-specific DNA binding
HZZ00_RS12115	COG0205	6-phosphofructokinase activity
HZZ00_RS12120	COG3442	glutamine amidotransferase
HZZ00_RS12130	COG0242	peptide deformylase activity
HZZ00_RS12140	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS12150	COG2124	cytochrome p450
HZZ00_RS12155	COG3424	synthase
HZZ00_RS12165	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS12175	COG1793	dna ligase
HZZ00_RS12180	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_RS12195	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS12200	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS12230	COG1063	alcohol dehydrogenase
HZZ00_RS12255	COG0586	Pfam SNARE associated Golgi protein
HZZ00_RS12335	COG0464	growth
HZZ00_RS12345	COG1506	peptidase
HZZ00_RS12345	COG4946	Tricorn protease homolog
HZZ00_RS12345	COG0823	Involved in the tonB-independent uptake of proteins
HZZ00_RS12360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_RS12375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_RS12410	COG3959	Transketolase, thiamine diphosphate binding domain
HZZ00_RS12420	COG0443	Heat shock 70 kDa protein
HZZ00_RS12425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZZ00_RS12440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_RS12465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZZ00_RS12465	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_RS12475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_RS12480	COG3938	Belongs to the proline racemase family
HZZ00_RS12490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_RS12505	COG0513	Belongs to the DEAD box helicase family
HZZ00_RS12510	COG1408	metallophosphoesterase
HZZ00_RS12520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_RS12565	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS12590	COG1940	carbohydrate kinase activity
HZZ00_RS12590	COG1846	Transcriptional regulator
HZZ00_RS12640	COG2018	Roadblock/LC7 domain
HZZ00_RS12650	COG1946	Acyl-CoA thioesterase
HZZ00_RS12665	COG0254	rRNA binding
HZZ00_RS12675	COG1132	(ABC) transporter
HZZ00_RS12705	COG1132	(ABC) transporter
HZZ00_RS12710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZZ00_RS12715	COG2072	flavoprotein involved in K transport
HZZ00_RS12720	COG0432	Pfam Uncharacterised protein family UPF0047
HZZ00_RS12725	COG1119	ATPase activity
HZZ00_RS12760	COG4245	von Willebrand factor, type A
HZZ00_RS12785	COG0542	response to heat
HZZ00_RS12795	COG1100	Small GTP-binding protein
HZZ00_RS12820	COG0714	Associated with various cellular activities
HZZ00_RS12845	COG0477	Major facilitator Superfamily
HZZ00_RS12865	COG2706	6-phosphogluconolactonase activity
HZZ00_RS12880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZZ00_RS12895	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS12910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZZ00_RS12925	COG1309	transcriptional regulator
HZZ00_RS12965	COG0584	glycerophosphoryl diester phosphodiesterase
HZZ00_RS13015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZZ00_RS13050	COG1660	Displays ATPase and GTPase activities
HZZ00_RS13060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_RS13065	COG0445	tRNA wobble uridine modification
HZZ00_RS13090	COG3631	Ketosteroid isomerase-related protein
HZZ00_RS13095	COG0702	epimerase
HZZ00_RS13110	COG0180	Tryptophanyl-tRNA synthetase
HZZ00_RS13130	COG1349	DNA-binding transcription factor activity
HZZ00_RS13135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZZ00_RS13140	COG0191	fructose-bisphosphate aldolase activity
HZZ00_RS13150	COG0456	acetyltransferase
HZZ00_RS13155	COG2813	Specifically methylates the guanine in position
HZZ00_RS13165	COG1940	carbohydrate kinase activity
HZZ00_RS13200	COG2226	methyltransferase
HZZ00_RS13210	COG2192	nodulation
HZZ00_RS13225	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_RS13230	COG0477	Major facilitator Superfamily
HZZ00_RS13260	COG1349	DNA-binding transcription factor activity
HZZ00_RS13295	COG1215	transferase activity, transferring glycosyl groups
HZZ00_RS13300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZZ00_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS13330	COG4191	Histidine kinase
HZZ00_RS13345	COG2801	Transposase and inactivated derivatives
HZZ00_RS13345	COG3415	Transposase
HZZ00_RS13360	COG3469	chitinase activity
HZZ00_RS13365	COG2340	Cysteine-rich secretory protein family
HZZ00_RS13370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZZ00_RS13410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZZ00_RS13455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZZ00_RS13460	COG1993	acr, cog1993
HZZ00_RS13465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZZ00_RS13470	COG1968	undecaprenyl-diphosphatase activity
HZZ00_RS13490	COG2066	Belongs to the glutaminase family
HZZ00_RS13505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZZ00_RS13510	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_RS13520	COG3458	cephalosporin-C deacetylase activity
HZZ00_RS13535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZZ00_RS13550	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_RS13570	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_RS13570	COG1902	pentaerythritol trinitrate reductase activity
HZZ00_RS13600	COG1461	Dihydroxyacetone kinase
HZZ00_RS13605	COG2376	Dihydroxyacetone kinase
HZZ00_RS13645	COG0464	growth
HZZ00_RS13665	COG1674	ftsk spoiiie
HZZ00_RS13680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_RS13685	COG2192	nodulation
HZZ00_RS13695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZZ00_RS13705	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS13710	COG0297	glycogen (starch) synthase activity
HZZ00_RS13715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HZZ00_RS13720	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZZ00_RS13720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZZ00_RS13775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS13785	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS13820	COG0510	thiamine kinase activity
HZZ00_RS13840	COG3511	phospholipase C
HZZ00_RS13845	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS13855	COG0367	asparagine synthase
HZZ00_RS13900	COG3250	beta-galactosidase activity
HZZ00_RS13905	COG0531	amino acid
HZZ00_RS13920	COG0667	Aldo Keto reductase
HZZ00_RS13935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_RS13945	COG0583	DNA-binding transcription factor activity
HZZ00_RS13950	COG0667	Aldo Keto reductase
HZZ00_RS13975	COG1191	sigma factor activity
HZZ00_RS14000	COG0328	RNA-DNA hybrid ribonuclease activity
HZZ00_RS14005	COG0667	Aldo Keto reductase
HZZ00_RS14020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS14025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZZ00_RS14060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_RS14160	COG1252	NADH dehydrogenase
HZZ00_RS14175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HZZ00_RS14180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZZ00_RS14185	COG3281	Trehalose synthase
HZZ00_RS14195	COG0366	Alpha amylase catalytic
HZZ00_RS14235	COG0842	Transport permease protein
HZZ00_RS14245	COG0181	hydroxymethylbilane synthase activity
HZZ00_RS14265	COG1846	Transcriptional regulator
HZZ00_RS14275	COG4221	oxidoreductase activity
HZZ00_RS14295	COG0656	L-ascorbic acid biosynthetic process
HZZ00_RS14310	COG4251	negative regulation of phosphorylation
HZZ00_RS14320	COG0784	Response regulator, receiver
HZZ00_RS14340	COG0596	Alpha beta hydrolase
HZZ00_RS14370	COG0009	L-threonylcarbamoyladenylate synthase
HZZ00_RS14405	COG0473	3-isopropylmalate dehydrogenase activity
HZZ00_RS14415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HZZ00_RS14510	COG0709	Synthesizes selenophosphate from selenide and ATP
HZZ00_RS14525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_RS14545	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_RS14560	COG0437	4 iron, 4 sulfur cluster binding
HZZ00_RS14565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZZ00_RS14595	COG2814	Major facilitator Superfamily
HZZ00_RS14600	COG0586	Pfam SNARE associated Golgi protein
HZZ00_RS14610	COG0667	Aldo Keto reductase
HZZ00_RS14615	COG0477	Major facilitator Superfamily
HZZ00_RS14655	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS14665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_RS14670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZZ00_RS14675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZZ00_RS14730	COG2050	protein possibly involved in aromatic compounds catabolism
HZZ00_RS14740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_RS14745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_RS14750	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS14755	COG1032	radical SAM domain protein
HZZ00_RS14775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZZ00_RS14800	COG1285	pathogenesis
HZZ00_RS14810	COG1024	Enoyl-CoA hydratase
HZZ00_RS14810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZZ00_RS14815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZZ00_RS14820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HZZ00_RS14825	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HZZ00_RS14830	COG0298	carbon dioxide binding
HZZ00_RS14845	COG0375	protein maturation
HZZ00_RS14870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HZZ00_RS14905	COG0701	Predicted permease
HZZ00_RS14915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZZ00_RS14930	COG0517	IMP dehydrogenase activity
HZZ00_RS14945	COG0517	IMP dehydrogenase activity
HZZ00_RS14945	COG0516	GMP reductase activity
HZZ00_RS14960	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HZZ00_RS14970	COG2239	Acts as a magnesium transporter
HZZ00_RS14980	COG0517	IMP dehydrogenase activity
HZZ00_RS14980	COG0516	GMP reductase activity
HZZ00_RS15030	COG0640	Transcriptional regulator
HZZ00_RS15035	COG1316	TRANSCRIPTIONal
HZZ00_RS15050	COG1090	epimerase
HZZ00_RS15060	COG2409	Drug exporters of the RND superfamily
HZZ00_RS15075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_RS15125	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS15130	COG5002	protein histidine kinase activity
HZZ00_RS15165	COG2080	2 iron, 2 sulfur cluster binding
HZZ00_RS15170	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZZ00_RS15175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZZ00_RS15195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZZ00_RS15210	COG2755	lipolytic protein G-D-S-L family
HZZ00_RS15215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_RS15245	COG1584	GPR1 FUN34 yaaH family protein
HZZ00_RS15275	COG2197	response regulator
HZZ00_RS15285	COG0583	DNA-binding transcription factor activity
HZZ00_RS15315	COG0517	IMP dehydrogenase activity
HZZ00_RS15315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZZ00_RS15315	COG0617	tRNA 3'-terminal CCA addition
HZZ00_RS15345	COG0531	amino acid
HZZ00_RS15430	COG2755	lipolytic protein G-D-S-L family
HZZ00_RS15470	COG3979	chitinase
HZZ00_RS15480	COG1177	transmembrane transport
HZZ00_RS15485	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZZ00_RS15490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZZ00_RS15495	COG3842	ATPase activity
HZZ00_RS15515	COG4221	oxidoreductase activity
HZZ00_RS15525	COG1132	(ABC) transporter
HZZ00_RS15555	COG0277	FAD linked oxidase domain protein
HZZ00_RS15560	COG1597	lipid kinase activity
HZZ00_RS15575	COG2837	iron assimilation
HZZ00_RS15580	COG0542	response to heat
HZZ00_RS15585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZZ00_RS15620	COG1396	sequence-specific DNA binding
HZZ00_RS15635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZZ00_RS15645	COG1554	hydrolase, family 65, central catalytic
HZZ00_RS15670	COG0456	acetyltransferase
HZZ00_RS15795	COG1937	Protein conserved in bacteria
HZZ00_RS15840	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS15885	COG0646	methionine synthase
HZZ00_RS15885	COG1410	methionine synthase
HZZ00_RS15890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS15905	COG0736	holo-[acyl-carrier-protein] synthase activity
HZZ00_RS15920	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_RS15935	COG0626	cystathionine gamma-synthase activity
HZZ00_RS15955	COG2132	Multicopper oxidase
HZZ00_RS15960	COG1703	isobutyryl-CoA mutase activity
HZZ00_RS15960	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS15960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS15980	COG0174	glutamine synthetase
HZZ00_RS15995	COG4689	acetoacetate decarboxylase
HZZ00_RS16000	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS16010	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_RS16015	COG1309	transcriptional regulator
HZZ00_RS16025	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS16030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZZ00_RS16035	COG1846	Transcriptional regulator
HZZ00_RS16040	COG0789	Transcriptional regulator
HZZ00_RS16050	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HZZ00_RS16050	COG0778	Nitroreductase
HZZ00_RS16165	COG0831	urea catabolic process
HZZ00_RS16170	COG0832	Belongs to the urease beta subunit family
HZZ00_RS16175	COG0804	urea catabolic process
HZZ00_RS16180	COG0830	nickel cation binding
HZZ00_RS16185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HZZ00_RS16190	COG0829	nickel cation binding
HZZ00_RS16205	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_RS16225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZZ00_RS16275	COG0477	Major facilitator Superfamily
HZZ00_RS16345	COG1971	Probably functions as a manganese efflux pump
HZZ00_RS16355	COG0535	radical SAM domain protein
HZZ00_RS16370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZZ00_RS16390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZZ00_RS16395	COG3284	Transcriptional regulator
HZZ00_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS16445	COG1959	2 iron, 2 sulfur cluster binding
HZZ00_RS16450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_RS16455	COG2318	DinB family
HZZ00_RS16510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZZ00_RS16520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_RS16540	COG0667	Aldo Keto reductase
HZZ00_RS16570	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS16580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_RS16600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZZ00_RS16610	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HZZ00_RS16615	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS16625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_RS16630	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS16640	COG0789	Transcriptional regulator
HZZ00_RS16645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_RS16650	COG2124	cytochrome p450
HZZ00_RS16655	COG0475	glutathione-regulated potassium exporter activity
HZZ00_RS16670	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_RS16675	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS16680	COG0583	DNA-binding transcription factor activity
HZZ00_RS16690	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS16740	COG0384	phenazine biosynthesis protein PhzF
HZZ00_RS16755	COG2770	Histidine kinase
HZZ00_RS16755	COG2208	phosphoserine phosphatase activity
HZZ00_RS16780	COG5640	endopeptidase activity
HZZ00_RS16785	COG0583	DNA-binding transcription factor activity
HZZ00_RS16795	COG2308	Evidence 4 Homologs of previously reported genes of
HZZ00_RS16795	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HZZ00_RS16950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZZ00_RS16980	COG1609	Transcriptional regulator
HZZ00_RS16995	COG2160	L-arabinose isomerase activity
HZZ00_RS17005	COG1129	ABC transporter
HZZ00_RS17035	COG0596	Alpha beta hydrolase
HZZ00_RS17040	COG2208	phosphoserine phosphatase activity
HZZ00_RS17040	COG2770	Histidine kinase
HZZ00_RS17075	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS17135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZZ00_RS17145	COG2353	YceI-like domain
HZZ00_RS17155	COG4989	oxidoreductase activity
HZZ00_RS17175	COG0662	Cupin 2, conserved barrel domain protein
HZZ00_RS17180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZZ00_RS17195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS17200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HZZ00_RS17225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZZ00_RS17230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZZ00_RS17270	COG3833	ABC-type maltose transport systems, permease component
HZZ00_RS17275	COG0366	Alpha amylase catalytic
HZZ00_RS17280	COG1609	Transcriptional regulator
HZZ00_RS17285	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS17290	COG1175	transmembrane transport
HZZ00_RS17305	COG1501	Belongs to the glycosyl hydrolase 31 family
HZZ00_RS17330	COG0604	alcohol dehydrogenase
HZZ00_RS17415	COG0009	L-threonylcarbamoyladenylate synthase
HZZ00_RS17425	COG0300	oxidoreductase activity
HZZ00_RS17470	COG1295	ribonuclease BN
HZZ00_RS17490	COG0477	Major facilitator Superfamily
HZZ00_RS17495	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS17550	COG1846	Transcriptional regulator
HZZ00_RS17555	COG0789	Transcriptional regulator
HZZ00_RS17560	COG2807	transmembrane transport
HZZ00_RS17600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_RS17630	COG2197	response regulator
HZZ00_RS17640	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_RS17640	COG2319	Wd-40 repeat
HZZ00_RS17670	COG2267	carboxylic ester hydrolase activity
HZZ00_RS17690	COG0444	Belongs to the ABC transporter superfamily
HZZ00_RS17700	COG0747	negative chemotaxis
HZZ00_RS17710	COG3458	cephalosporin-C deacetylase activity
HZZ00_RS17720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_RS17730	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HZZ00_RS17745	COG3537	Alpha-1,2-mannosidase
HZZ00_RS17750	COG1335	isochorismatase
HZZ00_RS17815	COG3479	Phenolic acid decarboxylase
HZZ00_RS17825	COG1725	Transcriptional regulator
HZZ00_RS17830	COG1131	(ABC) transporter
HZZ00_RS17845	COG1073	alpha beta
HZZ00_RS17860	COG3940	Belongs to the glycosyl hydrolase 43 family
HZZ00_RS17875	COG1349	DNA-binding transcription factor activity
HZZ00_RS17880	COG2223	nitrite transmembrane transporter activity
HZZ00_RS17895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZZ00_RS17900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_RS17910	COG1737	Transcriptional regulator
HZZ00_RS17915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZZ00_RS17930	COG0300	oxidoreductase activity
HZZ00_RS17950	COG0488	(ABC) transporter
HZZ00_RS17980	COG3842	ATPase activity
HZZ00_RS17990	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZZ00_RS17995	COG1177	transmembrane transport
HZZ00_RS18005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZZ00_RS18090	COG1349	DNA-binding transcription factor activity
HZZ00_RS18100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZZ00_RS18100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZZ00_RS18100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZZ00_RS18170	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_RS18170	COG1902	pentaerythritol trinitrate reductase activity
HZZ00_RS18180	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_RS18180	COG2319	Wd-40 repeat
HZZ00_RS18185	COG3409	Peptidoglycan-binding domain 1 protein
HZZ00_RS18215	COG2124	cytochrome p450
HZZ00_RS18240	COG1335	isochorismatase
HZZ00_RS18280	COG3293	Transposase
HZZ00_RS18360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_RS18375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS18400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZZ00_RS18405	COG2192	nodulation
HZZ00_RS18435	COG1132	(ABC) transporter
HZZ00_RS18440	COG1132	(ABC) transporter
HZZ00_RS18450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_RS18460	COG2124	cytochrome p450
HZZ00_RS18600	COG0142	geranyltranstransferase activity
HZZ00_RS19080	COG1278	Cold shock
HZZ00_RS19175	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS19190	COG1484	DNA-dependent DNA replication
HZZ00_RS19265	COG0604	alcohol dehydrogenase
HZZ00_RS19265	COG3321	synthase
HZZ00_RS19265	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS19280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZZ00_RS19305	COG2197	response regulator
HZZ00_RS19360	COG0484	heat shock protein binding
HZZ00_RS19420	COG0667	Aldo Keto reductase
HZZ00_RS19430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_RS19475	COG0477	Major facilitator Superfamily
HZZ00_RS19485	COG1414	Transcriptional regulator
HZZ00_RS19515	COG3485	protocatechuate 3,4-dioxygenase
HZZ00_RS19520	COG3485	protocatechuate 3,4-dioxygenase
HZZ00_RS19525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZZ00_RS19530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_RS19540	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_RS19550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_RS19565	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_RS19590	COG1132	(ABC) transporter
HZZ00_RS19610	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZZ00_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS19650	COG1609	Transcriptional regulator
HZZ00_RS19665	COG1175	transmembrane transport
HZZ00_RS19670	COG3833	ABC-type maltose transport systems, permease component
HZZ00_RS19675	COG1733	regulation of RNA biosynthetic process
HZZ00_RS19680	COG0702	epimerase
HZZ00_RS19705	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS19710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_RS19735	COG1228	amidohydrolase
HZZ00_RS19740	COG0300	oxidoreductase activity
HZZ00_RS19745	COG1309	transcriptional regulator
HZZ00_RS19760	COG0300	oxidoreductase activity
HZZ00_RS19775	COG1309	transcriptional regulator
HZZ00_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS19790	COG2208	phosphoserine phosphatase activity
HZZ00_RS19790	COG2770	Histidine kinase
HZZ00_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS19835	COG1482	cell wall glycoprotein biosynthetic process
HZZ00_RS19845	COG0028	Belongs to the TPP enzyme family
HZZ00_RS19850	COG0069	glutamate synthase activity
HZZ00_RS19910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS19930	COG0583	DNA-binding transcription factor activity
HZZ00_RS19960	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZZ00_RS19965	COG1129	ABC transporter
HZZ00_RS19970	COG1879	ABC-type sugar transport system periplasmic component
HZZ00_RS19990	COG1309	transcriptional regulator
HZZ00_RS20000	COG0583	DNA-binding transcription factor activity
HZZ00_RS20015	COG2319	Wd-40 repeat
HZZ00_RS20015	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_RS20025	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HZZ00_RS20045	COG0515	serine threonine protein kinase
HZZ00_RS20045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_RS20050	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20055	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20065	COG1309	transcriptional regulator
HZZ00_RS20070	COG0583	DNA-binding transcription factor activity
HZZ00_RS20085	COG4257	antibiotic catabolic process
HZZ00_RS20140	COG1309	transcriptional regulator
HZZ00_RS20145	COG1609	Transcriptional regulator
HZZ00_RS20155	COG1175	transmembrane transport
HZZ00_RS20160	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS20185	COG4941	Belongs to the sigma-70 factor family
HZZ00_RS20190	COG3795	YCII-related domain
HZZ00_RS20195	COG0477	Major facilitator Superfamily
HZZ00_RS20205	COG0366	Alpha amylase catalytic
HZZ00_RS20210	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS20215	COG1175	transmembrane transport
HZZ00_RS20285	COG3629	intracellular signal transduction
HZZ00_RS20285	COG3903	Transcriptional regulator
HZZ00_RS20325	COG0596	Alpha beta hydrolase
HZZ00_RS20345	COG0589	response to stress
HZZ00_RS20355	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HZZ00_RS20360	COG0515	serine threonine protein kinase
HZZ00_RS20360	COG2815	serine threonine protein kinase
HZZ00_RS20365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZZ00_RS20370	COG2208	phosphoserine phosphatase activity
HZZ00_RS20370	COG2770	Histidine kinase
HZZ00_RS20375	COG0488	(ABC) transporter
HZZ00_RS20380	COG0488	(ABC) transporter
HZZ00_RS20400	COG2267	carboxylic ester hydrolase activity
HZZ00_RS20405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HZZ00_RS20435	COG2130	NADP-dependent
HZZ00_RS20445	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20455	COG0583	DNA-binding transcription factor activity
HZZ00_RS20480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZZ00_RS20500	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20550	COG0405	Gamma-glutamyltransferase
HZZ00_RS20575	COG0667	Aldo Keto reductase
HZZ00_RS20580	COG0789	Transcriptional regulator
HZZ00_RS20585	COG0577	efflux transmembrane transporter activity
HZZ00_RS20585	COG1136	(ABC) transporter
HZZ00_RS20590	COG0577	efflux transmembrane transporter activity
HZZ00_RS20625	COG2318	DinB family
HZZ00_RS20660	COG0656	L-ascorbic acid biosynthetic process
HZZ00_RS20665	COG0438	transferase activity, transferring glycosyl groups
HZZ00_RS20670	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20695	COG0789	Transcriptional regulator
HZZ00_RS20760	COG0589	response to stress
HZZ00_RS20765	COG2706	6-phosphogluconolactonase activity
HZZ00_RS20775	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_RS20780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZZ00_RS20785	COG3265	gluconokinase activity
HZZ00_RS20810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZZ00_RS20810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_RS20820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZZ00_RS20825	COG5297	Belongs to the glycosyl hydrolase family 6
HZZ00_RS20825	COG4733	cellulase activity
HZZ00_RS20830	COG5297	Belongs to the glycosyl hydrolase family 6
HZZ00_RS20835	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HZZ00_RS20850	COG0477	Major facilitator Superfamily
HZZ00_RS20860	COG0477	Major facilitator Superfamily
HZZ00_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20895	COG2072	flavoprotein involved in K transport
HZZ00_RS20900	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS20915	COG1309	transcriptional regulator
HZZ00_RS20940	COG1846	Transcriptional regulator
HZZ00_RS20945	COG2814	Major facilitator Superfamily
HZZ00_RS20955	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_RS20960	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_RS20965	COG2172	sigma factor antagonist activity
HZZ00_RS20990	COG1982	Orn Lys Arg decarboxylase major
HZZ00_RS20995	COG1473	amidohydrolase
HZZ00_RS21020	COG0248	Ppx GppA phosphatase
HZZ00_RS21050	COG3469	chitinase activity
HZZ00_RS21070	COG1595	DNA-templated transcription, initiation
HZZ00_RS21080	COG2814	Major facilitator Superfamily
HZZ00_RS21135	COG2197	response regulator
HZZ00_RS21140	COG4585	Histidine kinase
HZZ00_RS21170	COG0726	polysaccharide deacetylase
HZZ00_RS21180	COG2264	protein methyltransferase activity
HZZ00_RS21230	COG0590	tRNA wobble adenosine to inosine editing
HZZ00_RS21245	COG0583	DNA-binding transcription factor activity
HZZ00_RS21255	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_RS21270	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HZZ00_RS21285	COG0586	Pfam SNARE associated Golgi protein
HZZ00_RS21290	COG0671	phosphoesterase, PA-phosphatase related
HZZ00_RS21305	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_RS21315	COG4948	Mandelate Racemase Muconate Lactonizing
HZZ00_RS21320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_RS21325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZZ00_RS21340	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HZZ00_RS21405	COG1609	Transcriptional regulator
HZZ00_RS21410	COG1309	transcriptional regulator
HZZ00_RS21430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZZ00_RS21455	COG0583	DNA-binding transcription factor activity
HZZ00_RS21465	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS21495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZZ00_RS21520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZZ00_RS21575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_RS21580	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZZ00_RS21585	COG2814	Major facilitator Superfamily
HZZ00_RS21590	COG1309	transcriptional regulator
HZZ00_RS21605	COG0300	oxidoreductase activity
HZZ00_RS21615	COG0277	FAD linked oxidase domain protein
HZZ00_RS21615	COG0247	lactate metabolic process
HZZ00_RS21625	COG1335	isochorismatase
HZZ00_RS21685	COG4221	oxidoreductase activity
HZZ00_RS21705	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_RS21745	COG1595	DNA-templated transcription, initiation
HZZ00_RS21770	COG0667	Aldo Keto reductase
HZZ00_RS21780	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS21800	COG2124	cytochrome p450
HZZ00_RS21820	COG0435	Glutathione S-transferase
HZZ00_RS21850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZZ00_RS21860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS21900	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS21905	COG1796	DNA polymerase
HZZ00_RS21905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZZ00_RS21910	COG0546	phosphoglycolate phosphatase activity
HZZ00_RS21960	COG2706	6-phosphogluconolactonase activity
HZZ00_RS21970	COG1309	transcriptional regulator
HZZ00_RS21980	COG1357	PFAM Pentapeptide repeats (8 copies)
HZZ00_RS22005	COG0247	lactate metabolic process
HZZ00_RS22010	COG1139	Iron-sulfur cluster binding protein
HZZ00_RS22015	COG1556	Lactate utilization protein
HZZ00_RS22020	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS22055	COG1174	glycine betaine transport
HZZ00_RS22070	COG0542	response to heat
HZZ00_RS22080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HZZ00_RS22145	COG0596	Alpha beta hydrolase
HZZ00_RS22155	COG3251	PFAM MbtH domain protein
HZZ00_RS22175	COG2124	cytochrome p450
HZZ00_RS22195	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS22225	COG1175	transmembrane transport
HZZ00_RS22240	COG3507	Belongs to the glycosyl hydrolase 43 family
HZZ00_RS22265	COG0515	serine threonine protein kinase
HZZ00_RS22265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_RS22285	COG1388	LysM domain
HZZ00_RS22285	COG3103	Sh3 type 3 domain protein
HZZ00_RS22285	COG0791	NLP P60 protein
HZZ00_RS22300	COG0640	Transcriptional regulator
HZZ00_RS22310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_RS22340	COG3629	intracellular signal transduction
HZZ00_RS22350	COG2124	cytochrome p450
HZZ00_RS22360	COG0604	alcohol dehydrogenase
HZZ00_RS22440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZZ00_RS22455	COG3251	PFAM MbtH domain protein
HZZ00_RS22465	COG3340	Belongs to the peptidase S51 family
HZZ00_RS22475	COG2197	response regulator
HZZ00_RS22500	COG2124	cytochrome p450
HZZ00_RS22515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZZ00_RS22525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZZ00_RS22530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZZ00_RS22535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZZ00_RS22540	COG3251	PFAM MbtH domain protein
HZZ00_RS22545	COG0604	alcohol dehydrogenase
HZZ00_RS22565	COG1819	glycosyl
HZZ00_RS22575	COG1024	Enoyl-CoA hydratase
HZZ00_RS22600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_RS22615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_RS22620	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS22625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS22630	COG2197	response regulator
HZZ00_RS22635	COG4585	Histidine kinase
HZZ00_RS22660	COG3903	Transcriptional regulator
HZZ00_RS22660	COG3629	intracellular signal transduction
HZZ00_RS22690	COG0326	Molecular chaperone. Has ATPase activity
HZZ00_RS22695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZZ00_RS22700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS22735	COG3608	succinylglutamate desuccinylase aspartoacylase
HZZ00_RS22735	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZZ00_RS22750	COG0242	peptide deformylase activity
HZZ00_RS22755	COG1132	(ABC) transporter
HZZ00_RS22785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_RS22805	COG1940	carbohydrate kinase activity
HZZ00_RS22810	COG2814	Major facilitator Superfamily
HZZ00_RS22815	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS22820	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS22830	COG4214	carbohydrate transport
HZZ00_RS22840	COG4213	ABC transporter substrate-binding protein
HZZ00_RS22845	COG0596	Alpha beta hydrolase
HZZ00_RS22855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZZ00_RS22925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZZ00_RS22930	COG0121	glutamine amidotransferase
HZZ00_RS22935	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HZZ00_RS22940	COG2182	Extracellular solute-binding protein
HZZ00_RS22945	COG3360	Dodecin
HZZ00_RS22955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS22990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_RS23000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZZ00_RS23005	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HZZ00_RS23010	COG3971	2-oxopent-4-enoate hydratase activity
HZZ00_RS23015	COG1414	Transcriptional regulator
HZZ00_RS23020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZZ00_RS23025	COG1053	succinate dehydrogenase
HZZ00_RS23035	COG0583	DNA-binding transcription factor activity
HZZ00_RS23100	COG0531	amino acid
HZZ00_RS23115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZZ00_RS23140	COG0154	amidase activity
HZZ00_RS23185	COG3537	Alpha-1,2-mannosidase
HZZ00_RS23205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HZZ00_RS23210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZZ00_RS23215	COG2723	6-phospho-beta-galactosidase activity
HZZ00_RS23220	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS23225	COG1175	transmembrane transport
HZZ00_RS23230	COG2182	Extracellular solute-binding protein
HZZ00_RS23275	COG4948	Mandelate Racemase Muconate Lactonizing
HZZ00_RS23280	COG0028	Belongs to the TPP enzyme family
HZZ00_RS23295	COG3387	PFAM Glycoside hydrolase 15-related
HZZ00_RS23300	COG0028	Belongs to the TPP enzyme family
HZZ00_RS23305	COG3550	peptidyl-serine autophosphorylation
HZZ00_RS23325	COG0583	DNA-binding transcription factor activity
HZZ00_RS23335	COG2814	Major facilitator Superfamily
HZZ00_RS23340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS23375	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS23460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZZ00_RS23470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS23480	COG0583	DNA-binding transcription factor activity
HZZ00_RS23495	COG2124	cytochrome p450
HZZ00_RS23500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZZ00_RS23500	COG2070	2-Nitropropane dioxygenase
HZZ00_RS23505	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS23505	COG0300	oxidoreductase activity
HZZ00_RS23505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_RS23505	COG3321	synthase
HZZ00_RS23505	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS23520	COG0477	Major facilitator Superfamily
HZZ00_RS23535	COG0300	oxidoreductase activity
HZZ00_RS23535	COG3321	synthase
HZZ00_RS23535	COG4221	oxidoreductase activity
HZZ00_RS23535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_RS23545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS23570	COG0559	Belongs to the binding-protein-dependent transport system permease family
HZZ00_RS23610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZZ00_RS23625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_RS23625	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS23625	COG3321	synthase
HZZ00_RS23625	COG4221	oxidoreductase activity
HZZ00_RS23640	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS23645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_RS23655	COG0456	acetyltransferase
HZZ00_RS23660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZZ00_RS23680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZZ00_RS23705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZZ00_RS23710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZZ00_RS23715	COG2080	2 iron, 2 sulfur cluster binding
HZZ00_RS23720	COG1132	(ABC) transporter
HZZ00_RS23730	COG1024	Enoyl-CoA hydratase
HZZ00_RS23745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_RS23745	COG2022	thiamine diphosphate biosynthetic process
HZZ00_RS23750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZZ00_RS23760	COG0531	amino acid
HZZ00_RS23765	COG0668	transmembrane transport
HZZ00_RS23775	COG2838	Isocitrate dehydrogenase
HZZ00_RS23790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZZ00_RS23800	COG2124	cytochrome p450
HZZ00_RS23815	COG1404	Belongs to the peptidase S8 family
HZZ00_RS23845	COG3415	Transposase
HZZ00_RS23845	COG2801	Transposase and inactivated derivatives
HZZ00_RS23870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS23875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS23890	COG0765	amino acid transport
HZZ00_RS23910	COG0531	amino acid
HZZ00_RS23915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZZ00_RS23920	COG2197	response regulator
HZZ00_RS23925	COG4585	Histidine kinase
HZZ00_RS23975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZZ00_RS24020	COG3629	intracellular signal transduction
HZZ00_RS24020	COG3903	Transcriptional regulator
HZZ00_RS24115	COG1191	sigma factor activity
HZZ00_RS24130	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HZZ00_RS24160	COG1609	Transcriptional regulator
HZZ00_RS24165	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS24170	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS24180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZZ00_RS24215	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS24230	COG1609	Transcriptional regulator
HZZ00_RS24250	COG1733	regulation of RNA biosynthetic process
HZZ00_RS24280	COG1011	Hydrolase
HZZ00_RS24290	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS24295	COG0183	Belongs to the thiolase family
HZZ00_RS24300	COG2267	carboxylic ester hydrolase activity
HZZ00_RS24320	COG0561	phosphatase activity
HZZ00_RS24355	COG0529	Catalyzes the synthesis of activated sulfate
HZZ00_RS24370	COG3903	Transcriptional regulator
HZZ00_RS24370	COG3629	intracellular signal transduction
HZZ00_RS24395	COG3959	Transketolase, thiamine diphosphate binding domain
HZZ00_RS24400	COG3958	Transketolase
HZZ00_RS24415	COG0583	DNA-binding transcription factor activity
HZZ00_RS24420	COG0156	8-amino-7-oxononanoate synthase activity
HZZ00_RS24425	COG1063	alcohol dehydrogenase
HZZ00_RS24460	COG2755	lipolytic protein G-D-S-L family
HZZ00_RS24490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZZ00_RS24495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZZ00_RS24520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HZZ00_RS24530	COG1562	ergosterol biosynthetic process
HZZ00_RS24535	COG1134	teichoic acid transport
HZZ00_RS24580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HZZ00_RS24595	COG1024	Enoyl-CoA hydratase
HZZ00_RS24610	COG2183	response to ionizing radiation
HZZ00_RS24615	COG0488	(ABC) transporter
HZZ00_RS24625	COG2936	dipeptidyl-peptidase activity
HZZ00_RS24635	COG2223	nitrite transmembrane transporter activity
HZZ00_RS24645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZZ00_RS24645	COG2146	nitrite reductase [NAD(P)H] activity
HZZ00_RS24650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZZ00_RS24655	COG0243	molybdopterin cofactor binding
HZZ00_RS24660	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS24675	COG1113	amino acid transport
HZZ00_RS24685	COG1024	Enoyl-CoA hydratase
HZZ00_RS24685	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS24690	COG0183	Belongs to the thiolase family
HZZ00_RS24695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_RS24710	COG1515	deoxyribonuclease V activity
HZZ00_RS24735	COG0488	(ABC) transporter
HZZ00_RS24740	COG1834	amidinotransferase
HZZ00_RS24770	COG1793	dna ligase
HZZ00_RS24820	COG3511	phospholipase C
HZZ00_RS24850	COG1486	melibiose metabolic process
HZZ00_RS24875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZZ00_RS24890	COG0166	Belongs to the GPI family
HZZ00_RS24895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZZ00_RS24900	COG0406	alpha-ribazole phosphatase activity
HZZ00_RS24915	COG2084	Dehydrogenase
HZZ00_RS24920	COG3467	pyridoxamine 5'-phosphate
HZZ00_RS24980	COG0626	cystathionine gamma-synthase activity
HZZ00_RS24985	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZZ00_RS25000	COG3275	phosphorelay sensor kinase activity
HZZ00_RS25015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_RS25020	COG1584	GPR1 FUN34 yaaH family protein
HZZ00_RS25025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_RS25040	COG1414	Transcriptional regulator
HZZ00_RS25050	COG3142	Participates in the control of copper homeostasis
HZZ00_RS25060	COG1846	Transcriptional regulator
HZZ00_RS25060	COG1940	carbohydrate kinase activity
HZZ00_RS25065	COG0747	negative chemotaxis
HZZ00_RS25100	COG2124	cytochrome p450
HZZ00_RS25135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_RS25140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZZ00_RS25160	COG0583	DNA-binding transcription factor activity
HZZ00_RS25170	COG0656	L-ascorbic acid biosynthetic process
HZZ00_RS25185	COG4221	oxidoreductase activity
HZZ00_RS25200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZZ00_RS25205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HZZ00_RS25210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZZ00_RS25220	COG2226	methyltransferase
HZZ00_RS25225	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZZ00_RS25280	COG0028	Belongs to the TPP enzyme family
HZZ00_RS25295	COG0693	protein deglycase activity
HZZ00_RS25310	COG0488	(ABC) transporter
HZZ00_RS25320	COG1597	lipid kinase activity
HZZ00_RS25380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZZ00_RS25415	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZZ00_RS25425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_RS25430	COG2362	D-Aminopeptidase
HZZ00_RS25440	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_RS25480	COG1309	transcriptional regulator
HZZ00_RS25495	COG1309	transcriptional regulator
HZZ00_RS25505	COG2409	Drug exporters of the RND superfamily
HZZ00_RS25510	COG1063	alcohol dehydrogenase
HZZ00_RS25525	COG0183	Belongs to the thiolase family
HZZ00_RS25530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZZ00_RS25535	COG1024	Enoyl-CoA hydratase
HZZ00_RS25545	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS25550	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS25565	COG0604	alcohol dehydrogenase
HZZ00_RS25580	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS25590	COG1309	transcriptional regulator
HZZ00_RS25620	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS25630	COG1024	Enoyl-CoA hydratase
HZZ00_RS25650	COG1024	Enoyl-CoA hydratase
HZZ00_RS25685	COG0596	Alpha beta hydrolase
HZZ00_RS25695	COG1295	ribonuclease BN
HZZ00_RS25710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS25720	COG0604	alcohol dehydrogenase
HZZ00_RS25725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS25725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS25730	COG2301	Belongs to the HpcH HpaI aldolase family
HZZ00_RS25740	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS25745	COG0688	phosphatidylethanolamine metabolic process
HZZ00_RS25755	COG1929	Belongs to the glycerate kinase type-1 family
HZZ00_RS25770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZZ00_RS25785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZZ00_RS25795	COG2124	cytochrome p450
HZZ00_RS25800	COG2124	cytochrome p450
HZZ00_RS25830	COG0477	Major facilitator Superfamily
HZZ00_RS25845	COG0483	inositol monophosphate 1-phosphatase activity
HZZ00_RS25895	COG1953	Uracil, thiamine, allantoin
HZZ00_RS25905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZZ00_RS25920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_RS25935	COG0542	response to heat
HZZ00_RS25940	COG0405	Gamma-glutamyltransferase
HZZ00_RS25955	COG0708	Exodeoxyribonuclease III
HZZ00_RS25965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_RS25970	COG0702	epimerase
HZZ00_RS26020	COG0783	Belongs to the Dps family
HZZ00_RS26030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZZ00_RS26035	COG1335	isochorismatase
HZZ00_RS26040	COG2259	Doxx family
HZZ00_RS26045	COG3619	membrane
HZZ00_RS26050	COG2814	Major facilitator Superfamily
HZZ00_RS26065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS26075	COG0028	Belongs to the TPP enzyme family
HZZ00_RS26105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZZ00_RS26110	COG0798	PFAM Bile acid sodium symporter
HZZ00_RS26115	COG0640	Transcriptional regulator
HZZ00_RS26120	COG2226	methyltransferase
HZZ00_RS26135	COG1937	Protein conserved in bacteria
HZZ00_RS26145	COG0730	response to heat
HZZ00_RS26155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_RS26160	COG2814	Major facilitator Superfamily
HZZ00_RS26180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZZ00_RS26190	COG1940	carbohydrate kinase activity
HZZ00_RS26195	COG1129	ABC transporter
HZZ00_RS26210	COG2188	Transcriptional regulator
HZZ00_RS26215	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS26245	COG4266	Belongs to the allantoicase family
HZZ00_RS26250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZZ00_RS26255	COG1414	Transcriptional regulator
HZZ00_RS26280	COG2340	Cysteine-rich secretory protein family
HZZ00_RS26290	COG4264	IucA IucC family
HZZ00_RS26305	COG1733	regulation of RNA biosynthetic process
HZZ00_RS26310	COG0436	Aminotransferase
HZZ00_RS26320	COG0406	alpha-ribazole phosphatase activity
HZZ00_RS26335	COG2233	PERMEase
HZZ00_RS26350	COG2351	hydroxyisourate hydrolase activity
HZZ00_RS26370	COG3622	Belongs to the hyi family
HZZ00_RS26375	COG2084	Dehydrogenase
HZZ00_RS26380	COG0753	catalase activity
HZZ00_RS26395	COG3960	tartronate-semialdehyde synthase activity
HZZ00_RS26405	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS26410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_RS26415	COG2197	response regulator
HZZ00_RS26435	COG0583	DNA-binding transcription factor activity
HZZ00_RS26445	COG1653	transport
HZZ00_RS26460	COG0515	serine threonine protein kinase
HZZ00_RS26470	COG0726	polysaccharide deacetylase
HZZ00_RS26490	COG2252	PERMEase
HZZ00_RS26495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZZ00_RS26525	COG1802	Transcriptional regulator
HZZ00_RS26540	COG0028	Belongs to the TPP enzyme family
HZZ00_RS26560	COG2267	carboxylic ester hydrolase activity
HZZ00_RS26570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZZ00_RS26585	COG1162	GTPase activity
HZZ00_RS26605	COG0277	FAD linked oxidase domain protein
HZZ00_RS26630	COG2040	homocysteine
HZZ00_RS26645	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HZZ00_RS26675	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS26690	COG0456	acetyltransferase
HZZ00_RS26705	COG0175	sulfate reduction
HZZ00_RS26710	COG0529	Catalyzes the synthesis of activated sulfate
HZZ00_RS26735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZZ00_RS26755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZZ00_RS26795	COG0583	DNA-binding transcription factor activity
HZZ00_RS26800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZZ00_RS26830	COG3173	Aminoglycoside phosphotransferase
HZZ00_RS26890	COG1732	Glycine betaine
HZZ00_RS26895	COG1174	glycine betaine transport
HZZ00_RS26900	COG1174	glycine betaine transport
HZZ00_RS26910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZZ00_RS26915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZZ00_RS26955	COG0778	Nitroreductase
HZZ00_RS26965	COG2326	polyphosphate kinase activity
HZZ00_RS26970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_RS26970	COG0723	plastoquinol--plastocyanin reductase activity
HZZ00_RS26975	COG0726	polysaccharide deacetylase
HZZ00_RS26985	COG4152	abc transporter atp-binding protein
HZZ00_RS26995	COG3220	belongs to the UPF0276 family
HZZ00_RS27020	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZZ00_RS27055	COG2267	carboxylic ester hydrolase activity
HZZ00_RS27065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZZ00_RS27080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HZZ00_RS27085	COG0183	Belongs to the thiolase family
HZZ00_RS27090	COG1024	Enoyl-CoA hydratase
HZZ00_RS27090	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS27105	COG0531	amino acid
HZZ00_RS27110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZZ00_RS27115	COG4214	carbohydrate transport
HZZ00_RS27125	COG4213	ABC transporter substrate-binding protein
HZZ00_RS27130	COG1940	carbohydrate kinase activity
HZZ00_RS27135	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS27140	COG1175	transmembrane transport
HZZ00_RS27145	COG1653	transport
HZZ00_RS27155	COG1556	Lactate utilization protein
HZZ00_RS27160	COG1139	Iron-sulfur cluster binding protein
HZZ00_RS27165	COG0247	lactate metabolic process
HZZ00_RS27170	COG1620	l-lactate permease
HZZ00_RS27175	COG2186	Transcriptional regulator
HZZ00_RS27180	COG3290	protein histidine kinase activity
HZZ00_RS27185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZZ00_RS27200	COG1522	sequence-specific DNA binding
HZZ00_RS27205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZZ00_RS27215	COG1309	transcriptional regulator
HZZ00_RS27260	COG1472	Belongs to the glycosyl hydrolase 3 family
HZZ00_RS27265	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS27270	COG1175	transmembrane transport
HZZ00_RS27275	COG2182	Extracellular solute-binding protein
HZZ00_RS27280	COG2188	Transcriptional regulator
HZZ00_RS27295	COG1597	lipid kinase activity
HZZ00_RS27305	COG0477	Major facilitator Superfamily
HZZ00_RS27320	COG0477	Major facilitator Superfamily
HZZ00_RS27360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZZ00_RS27385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZZ00_RS27390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_RS27395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZZ00_RS27405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZZ00_RS27410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZZ00_RS27415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZZ00_RS27420	COG2814	Major facilitator Superfamily
HZZ00_RS27445	COG3629	intracellular signal transduction
HZZ00_RS27450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_RS27460	COG3415	Transposase
HZZ00_RS27460	COG2801	Transposase and inactivated derivatives
HZZ00_RS27495	COG1024	Enoyl-CoA hydratase
HZZ00_RS27505	COG0531	amino acid
HZZ00_RS27510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZZ00_RS27525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZZ00_RS27530	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_RS27535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS27560	COG1799	cell septum assembly
HZZ00_RS27605	COG1846	Transcriptional regulator
HZZ00_RS27625	COG0475	glutathione-regulated potassium exporter activity
HZZ00_RS27640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZZ00_RS27660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZZ00_RS27675	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS27705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZZ00_RS27735	COG3629	intracellular signal transduction
HZZ00_RS27735	COG3903	Transcriptional regulator
HZZ00_RS27740	COG1136	(ABC) transporter
HZZ00_RS27750	COG3629	intracellular signal transduction
HZZ00_RS27750	COG3903	Transcriptional regulator
HZZ00_RS27755	COG2197	response regulator
HZZ00_RS27770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZZ00_RS27780	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_RS27795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZZ00_RS27850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZZ00_RS27855	COG3845	ABC transporter
HZZ00_RS27860	COG1122	ATPase activity
HZZ00_RS27870	COG3345	alpha-galactosidase
HZZ00_RS27920	COG3654	unkown
HZZ00_RS27930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZZ00_RS27935	COG0531	amino acid
HZZ00_RS27940	COG0569	domain protein
HZZ00_RS27970	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZZ00_RS27970	COG1136	(ABC) transporter
HZZ00_RS27980	COG0756	dUTP diphosphatase activity
HZZ00_RS28005	COG2205	protein histidine kinase activity
HZZ00_RS28010	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS28020	COG0483	inositol monophosphate 1-phosphatase activity
HZZ00_RS28060	COG1435	thymidine kinase activity
HZZ00_RS28080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZZ00_RS28085	COG1802	Transcriptional regulator
HZZ00_RS28100	COG0612	Peptidase, M16
HZZ00_RS28105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZZ00_RS28115	COG0372	Belongs to the citrate synthase family
HZZ00_RS28130	COG3290	protein histidine kinase activity
HZZ00_RS28140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZZ00_RS28150	COG4565	transcriptional regulatory protein
HZZ00_RS28155	COG3415	Transposase
HZZ00_RS28155	COG2801	Transposase and inactivated derivatives
HZZ00_RS28160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZZ00_RS28170	COG2197	response regulator
HZZ00_RS28185	COG0187	DNA topoisomerase II activity
HZZ00_RS28210	COG1802	Transcriptional regulator
HZZ00_RS28215	COG1126	abc transporter atp-binding protein
HZZ00_RS28235	COG0514	ATP-dependent DNA helicase (RecQ)
HZZ00_RS28250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZZ00_RS28275	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS28285	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZZ00_RS28290	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZZ00_RS28290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZZ00_RS28295	COG4865	methylaspartate mutase activity
HZZ00_RS28320	COG1309	transcriptional regulator
HZZ00_RS28330	COG0588	phosphoglycerate mutase activity
HZZ00_RS28345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZZ00_RS28350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZZ00_RS28355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZZ00_RS28385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZZ00_RS28395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZZ00_RS28400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZZ00_RS28410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZZ00_RS28430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZZ00_RS28450	COG2358	TRAP transporter, solute receptor (TAXI family
HZZ00_RS28455	COG2205	protein histidine kinase activity
HZZ00_RS28460	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS28465	COG1126	abc transporter atp-binding protein
HZZ00_RS28470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZZ00_RS28475	COG0765	amino acid transport
HZZ00_RS28480	COG0765	amino acid transport
HZZ00_RS28495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZZ00_RS28535	COG1917	Cupin 2, conserved barrel domain protein
HZZ00_RS28535	COG2207	Transcriptional regulator
HZZ00_RS28540	COG1201	RNA secondary structure unwinding
HZZ00_RS28545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZZ00_RS28560	COG1396	sequence-specific DNA binding
HZZ00_RS28565	COG1058	Belongs to the CinA family
HZZ00_RS28565	COG1546	Belongs to the CinA family
HZZ00_RS28575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZZ00_RS28585	COG1674	ftsk spoiiie
HZZ00_RS28595	COG2205	protein histidine kinase activity
HZZ00_RS28595	COG0784	Response regulator, receiver
HZZ00_RS28600	COG2770	Histidine kinase
HZZ00_RS28600	COG2208	phosphoserine phosphatase activity
HZZ00_RS28630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZZ00_RS28635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZZ00_RS28640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HZZ00_RS28660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZZ00_RS28665	COG0612	Peptidase, M16
HZZ00_RS28670	COG1185	polyribonucleotide nucleotidyltransferase activity
HZZ00_RS28675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZZ00_RS28695	COG1674	ftsk spoiiie
HZZ00_RS28710	COG1404	Belongs to the peptidase S8 family
HZZ00_RS28725	COG1404	Belongs to the peptidase S8 family
HZZ00_RS28745	COG0455	bacterial-type flagellum organization
HZZ00_RS28760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZZ00_RS28765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZZ00_RS28775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZZ00_RS28790	COG0779	Required for maturation of 30S ribosomal subunits
HZZ00_RS28810	COG0442	prolyl-tRNA aminoacylation
HZZ00_RS28825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZZ00_RS28830	COG0750	zinc metalloprotease
HZZ00_RS28835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZZ00_RS28880	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS28915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZZ00_RS28920	COG1177	transmembrane transport
HZZ00_RS28925	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZZ00_RS28930	COG3842	ATPase activity
HZZ00_RS28940	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS28955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_RS28960	COG0584	glycerophosphoryl diester phosphodiesterase
HZZ00_RS28985	COG3876	Protein conserved in bacteria
HZZ00_RS29030	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS29040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZZ00_RS29070	COG3842	ATPase activity
HZZ00_RS29075	COG4208	sulfate ABC transporter
HZZ00_RS29085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZZ00_RS29095	COG1064	alcohol dehydrogenase
HZZ00_RS29105	COG0575	Belongs to the CDS family
HZZ00_RS29115	COG0233	cytoplasmic translational termination
HZZ00_RS29120	COG0528	UMP kinase activity
HZZ00_RS29125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZZ00_RS29130	COG0052	Belongs to the universal ribosomal protein uS2 family
HZZ00_RS29145	COG1191	sigma factor activity
HZZ00_RS29160	COG0792	nuclease activity
HZZ00_RS29180	COG0681	Belongs to the peptidase S26 family
HZZ00_RS29190	COG0681	Belongs to the peptidase S26 family
HZZ00_RS29195	COG0335	large ribosomal subunit rRNA binding
HZZ00_RS29200	COG0336	Belongs to the RNA methyltransferase TrmD family
HZZ00_RS29205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZZ00_RS29210	COG1837	Belongs to the UPF0109 family
HZZ00_RS29215	COG0228	four-way junction DNA binding
HZZ00_RS29225	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_RS29230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZZ00_RS29240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZZ00_RS29270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZZ00_RS29280	COG0477	Major facilitator Superfamily
HZZ00_RS29285	COG1196	nuclear chromosome segregation
HZZ00_RS29295	COG1254	Belongs to the acylphosphatase family
HZZ00_RS29310	COG1733	regulation of RNA biosynthetic process
HZZ00_RS29315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZZ00_RS29320	COG0571	ribonuclease III activity
HZZ00_RS29325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZZ00_RS29340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZZ00_RS29345	COG0742	ribosomal rna small subunit methyltransferase
HZZ00_RS29355	COG1461	Dihydroxyacetone kinase
HZZ00_RS29360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZZ00_RS29365	COG0351	phosphomethylpyrimidine kinase
HZZ00_RS29385	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZZ00_RS29390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZZ00_RS29400	COG1920	GTP binding
HZZ00_RS29410	COG0776	regulation of translation
HZZ00_RS29420	COG0066	3-isopropylmalate dehydratase activity
HZZ00_RS29425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZZ00_RS29430	COG1414	Transcriptional regulator
HZZ00_RS29475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZZ00_RS29480	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZZ00_RS29495	COG5002	protein histidine kinase activity
HZZ00_RS29500	COG2018	Roadblock/LC7 domain
HZZ00_RS29520	COG2018	Roadblock/LC7 domain
HZZ00_RS29540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_RS29545	COG2353	YceI-like domain
HZZ00_RS29575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZZ00_RS29580	COG0477	Major facilitator Superfamily
HZZ00_RS29595	COG2957	Belongs to the agmatine deiminase family
HZZ00_RS29600	COG0804	urea catabolic process
HZZ00_RS29605	COG0831	urea catabolic process
HZZ00_RS29605	COG0832	Belongs to the urease beta subunit family
HZZ00_RS29610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZZ00_RS29615	COG0473	3-isopropylmalate dehydrogenase activity
HZZ00_RS29625	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS29635	COG3835	regulator
HZZ00_RS29660	COG0477	Major facilitator Superfamily
HZZ00_RS29665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZZ00_RS29670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZZ00_RS29675	COG0440	acetolactate synthase activity
HZZ00_RS29685	COG5001	Diguanylate cyclase
HZZ00_RS29685	COG3300	MHYT domain
HZZ00_RS29695	COG0667	Aldo Keto reductase
HZZ00_RS29700	COG2133	pyrroloquinoline quinone binding
HZZ00_RS29710	COG2197	response regulator
HZZ00_RS29725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZZ00_RS29730	COG2409	Drug exporters of the RND superfamily
HZZ00_RS29735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZZ00_RS29745	COG0154	amidase activity
HZZ00_RS29750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZZ00_RS29770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZZ00_RS29780	COG4221	oxidoreductase activity
HZZ00_RS29800	COG0482	sulfurtransferase activity
HZZ00_RS29825	COG2378	regulation of single-species biofilm formation
HZZ00_RS29845	COG2860	membrane
HZZ00_RS29855	COG4608	Belongs to the ABC transporter superfamily
HZZ00_RS29860	COG0444	Belongs to the ABC transporter superfamily
HZZ00_RS29865	COG0601	transmembrane transport
HZZ00_RS29870	COG0747	negative chemotaxis
HZZ00_RS29875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZZ00_RS29895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZZ00_RS29900	COG0509	glycine decarboxylation via glycine cleavage system
HZZ00_RS29905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_RS29910	COG1760	l-serine dehydratase
HZZ00_RS29920	COG1733	regulation of RNA biosynthetic process
HZZ00_RS29925	COG3757	hydrolase, family 25
HZZ00_RS29925	COG3409	Peptidoglycan-binding domain 1 protein
HZZ00_RS29960	COG1024	Enoyl-CoA hydratase
HZZ00_RS29970	COG1376	ErfK ybiS ycfS ynhG family protein
HZZ00_RS29990	COG1215	transferase activity, transferring glycosyl groups
HZZ00_RS30005	COG1132	(ABC) transporter
HZZ00_RS30010	COG1132	(ABC) transporter
HZZ00_RS30015	COG1131	(ABC) transporter
HZZ00_RS30025	COG4585	Histidine kinase
HZZ00_RS30030	COG2197	response regulator
HZZ00_RS30035	COG1132	(ABC) transporter
HZZ00_RS30040	COG1132	(ABC) transporter
HZZ00_RS30060	COG0058	SHG alpha-glucan phosphorylase activity
HZZ00_RS30065	COG0366	Alpha amylase catalytic
HZZ00_RS30075	COG3281	Trehalose synthase
HZZ00_RS30080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZZ00_RS30090	COG3118	belongs to the thioredoxin family
HZZ00_RS30090	COG0492	ferredoxin-NADP+ reductase activity
HZZ00_RS30095	COG0789	Transcriptional regulator
HZZ00_RS30105	COG0477	Major facilitator Superfamily
HZZ00_RS30115	COG1301	dicarboxylic acid transport
HZZ00_RS30120	COG3290	protein histidine kinase activity
HZZ00_RS30125	COG4565	transcriptional regulatory protein
HZZ00_RS30135	COG1175	transmembrane transport
HZZ00_RS30140	COG0395	ABC-type sugar transport system, permease component
HZZ00_RS30145	COG0205	6-phosphofructokinase activity
HZZ00_RS30150	COG0857	belongs to the CobB CobQ family
HZZ00_RS30150	COG0280	phosphate acetyltransferase
HZZ00_RS30155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZZ00_RS30190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS30190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS30255	COG0183	Belongs to the thiolase family
HZZ00_RS30275	COG1131	(ABC) transporter
HZZ00_RS30310	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HZZ00_RS30315	COG0583	DNA-binding transcription factor activity
HZZ00_RS30325	COG2814	Major facilitator Superfamily
HZZ00_RS30350	COG0431	NADPH-dependent FMN reductase
HZZ00_RS30355	COG2986	histidine ammonia-lyase
HZZ00_RS30375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS30410	COG4585	Histidine kinase
HZZ00_RS30415	COG2197	response regulator
HZZ00_RS30430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZZ00_RS30435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZZ00_RS30440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZZ00_RS30445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZZ00_RS30450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZZ00_RS30455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZZ00_RS30460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZZ00_RS30475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZZ00_RS30480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_RS30485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZZ00_RS30495	COG2890	protein-(glutamine-N5) methyltransferase activity
HZZ00_RS30500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZZ00_RS30505	COG0254	rRNA binding
HZZ00_RS30520	COG0083	homoserine kinase activity
HZZ00_RS30525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HZZ00_RS30530	COG0460	homoserine dehydrogenase
HZZ00_RS30535	COG0019	diaminopimelate decarboxylase activity
HZZ00_RS30540	COG0018	arginyl-trna synthetase
HZZ00_RS30540	COG0018	arginyl-trna synthetase
HZZ00_RS30670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HZZ00_RS30675	COG1793	dna ligase
HZZ00_RS30675	COG3285	dna ligase
HZZ00_RS30695	COG2205	protein histidine kinase activity
HZZ00_RS30705	COG0768	penicillin binding
HZZ00_RS30790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZZ00_RS30805	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS30810	COG2205	protein histidine kinase activity
HZZ00_RS30815	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_RS30815	COG0567	Dehydrogenase, E1 component
HZZ00_RS30835	COG0604	alcohol dehydrogenase
HZZ00_RS30840	COG0281	malic enzyme
HZZ00_RS30855	COG1126	abc transporter atp-binding protein
HZZ00_RS30860	COG4106	trans-aconitate 2-methyltransferase activity
HZZ00_RS30900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZZ00_RS30905	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HZZ00_RS30920	COG2172	sigma factor antagonist activity
HZZ00_RS30935	COG1597	lipid kinase activity
HZZ00_RS30950	COG0363	glucosamine-6-phosphate deaminase activity
HZZ00_RS30955	COG2188	Transcriptional regulator
HZZ00_RS30990	COG4977	sequence-specific DNA binding
HZZ00_RS30995	COG2124	cytochrome p450
HZZ00_RS31005	COG0242	peptide deformylase activity
HZZ00_RS31015	COG5662	AntiSigma factor
HZZ00_RS31020	COG1595	DNA-templated transcription, initiation
HZZ00_RS31030	COG2135	peptidase activity
HZZ00_RS31040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZZ00_RS31045	COG1162	GTPase activity
HZZ00_RS31050	COG2076	Multidrug Resistance protein
HZZ00_RS31060	COG0483	inositol monophosphate 1-phosphatase activity
HZZ00_RS31070	COG0753	catalase activity
HZZ00_RS31095	COG1615	UPF0182 protein
HZZ00_RS31105	COG3480	Lon protease (S16) C-terminal proteolytic domain
HZZ00_RS31160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZZ00_RS31195	COG2816	NAD+ diphosphatase activity
HZZ00_RS31200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_RS31205	COG0210	DNA helicase
HZZ00_RS31255	COG4172	Belongs to the ABC transporter superfamily
HZZ00_RS31260	COG0601	transmembrane transport
HZZ00_RS31265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZZ00_RS31270	COG0747	negative chemotaxis
HZZ00_RS31310	COG0513	Belongs to the DEAD box helicase family
HZZ00_RS31320	COG1432	Conserved Protein
HZZ00_RS31330	COG2095	MarC family integral membrane protein
HZZ00_RS31345	COG2814	Major facilitator Superfamily
HZZ00_RS31355	COG0598	Magnesium transport protein CorA
HZZ00_RS31390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZZ00_RS31395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZZ00_RS31405	COG1595	DNA-templated transcription, initiation
HZZ00_RS31420	COG1024	Enoyl-CoA hydratase
HZZ00_RS31425	COG0519	Catalyzes the synthesis of GMP from XMP
HZZ00_RS31435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZZ00_RS31440	COG1611	Belongs to the LOG family
HZZ00_RS31445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZZ00_RS31480	COG2197	response regulator
HZZ00_RS31485	COG4585	Histidine kinase
HZZ00_RS31495	COG1131	(ABC) transporter
HZZ00_RS31510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZZ00_RS31525	COG4608	Belongs to the ABC transporter superfamily
HZZ00_RS31530	COG0444	Belongs to the ABC transporter superfamily
HZZ00_RS31540	COG0601	transmembrane transport
HZZ00_RS31545	COG4166	transmembrane transport
HZZ00_RS31555	COG0747	negative chemotaxis
HZZ00_RS31565	COG0444	Belongs to the ABC transporter superfamily
HZZ00_RS31570	COG4608	Belongs to the ABC transporter superfamily
HZZ00_RS31580	COG4608	Belongs to the ABC transporter superfamily
HZZ00_RS31585	COG0444	Belongs to the ABC transporter superfamily
HZZ00_RS31590	COG0601	transmembrane transport
HZZ00_RS31595	COG4166	transmembrane transport
HZZ00_RS31625	COG1053	succinate dehydrogenase
HZZ00_RS31695	COG0515	serine threonine protein kinase
HZZ00_RS31730	COG1454	alcohol dehydrogenase
HZZ00_RS31735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZZ00_RS31750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS31780	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS31785	COG2205	protein histidine kinase activity
HZZ00_RS31815	COG1192	Involved in chromosome partitioning
HZZ00_RS31845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZZ00_RS31860	COG0012	GTP binding
HZZ00_RS31875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZZ00_RS31880	COG1570	exodeoxyribonuclease VII activity
HZZ00_RS31885	COG1722	exodeoxyribonuclease VII activity
HZZ00_RS31890	COG0778	Nitroreductase
HZZ00_RS31915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZZ00_RS31915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZZ00_RS31920	COG0114	fumarate hydratase activity
HZZ00_RS31935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_RS31945	COG1136	(ABC) transporter
HZZ00_RS31960	COG0450	alkyl hydroperoxide reductase
HZZ00_RS31965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_RS31980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZZ00_RS31985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZZ00_RS31990	COG2226	methyltransferase
HZZ00_RS32000	COG2885	chlorophyll binding
HZZ00_RS32015	COG2197	response regulator
HZZ00_RS32020	COG3850	Histidine kinase
HZZ00_RS32050	COG2894	cell division
HZZ00_RS32085	COG2610	gluconate transmembrane transporter activity
HZZ00_RS32090	COG0251	oxidation-reduction process
HZZ00_RS32095	COG1414	Transcriptional regulator
HZZ00_RS32110	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HZZ00_RS32125	COG0436	Aminotransferase
HZZ00_RS32135	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HZZ00_RS32140	COG1272	protein, Hemolysin III
HZZ00_RS32145	COG1309	transcriptional regulator
HZZ00_RS32160	COG1331	Highly conserved protein containing a thioredoxin domain
HZZ00_RS32185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZZ00_RS32195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZZ00_RS32200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZZ00_RS32240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZZ00_RS32245	COG1064	alcohol dehydrogenase
HZZ00_RS32255	COG1136	(ABC) transporter
HZZ00_RS32285	COG2986	histidine ammonia-lyase
HZZ00_RS32295	COG1024	Enoyl-CoA hydratase
HZZ00_RS32305	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HZZ00_RS32315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZZ00_RS32325	COG0424	maF-like protein
HZZ00_RS32335	COG4770	biotin carboxylase activity
HZZ00_RS32365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZZ00_RS32410	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS32415	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS32445	COG1595	DNA-templated transcription, initiation
HZZ00_RS32450	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS32455	COG2205	protein histidine kinase activity
HZZ00_RS32480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_RS32490	COG0583	DNA-binding transcription factor activity
HZZ00_RS32495	COG2814	Major facilitator Superfamily
HZZ00_RS32500	COG0592	DNA-directed DNA polymerase activity
HZZ00_RS32545	COG1473	amidohydrolase
HZZ00_RS32545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HZZ00_RS32585	COG2089	acid synthase
HZZ00_RS32600	COG1216	Glycosyl transferase, family 2
HZZ00_RS32630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS32630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS32640	COG1595	DNA-templated transcription, initiation
HZZ00_RS32670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZZ00_RS32680	COG2009	succinate dehydrogenase
HZZ00_RS32690	COG1053	succinate dehydrogenase
HZZ00_RS32710	COG1309	transcriptional regulator
HZZ00_RS32730	COG1295	ribonuclease BN
HZZ00_RS32745	COG0180	Tryptophanyl-tRNA synthetase
HZZ00_RS32750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZZ00_RS32760	COG0754	glutathionylspermidine amidase activity
HZZ00_RS32780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_RS32785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZZ00_RS32800	COG4176	ABC-type proline glycine betaine transport system permease component
HZZ00_RS32805	COG4175	Glycine betaine
HZZ00_RS32805	COG0517	IMP dehydrogenase activity
HZZ00_RS32815	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS32820	COG0039	L-malate dehydrogenase activity
HZZ00_RS32835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZZ00_RS32845	COG0138	bifunctional purine biosynthesis protein purh
HZZ00_RS32875	COG0045	succinate-CoA ligase (ADP-forming) activity
HZZ00_RS32880	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HZZ00_RS32890	COG0714	Associated with various cellular activities
HZZ00_RS32905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS32905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZZ00_RS32910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HZZ00_RS32935	COG0791	NLP P60 protein
HZZ00_RS32940	COG2197	response regulator
HZZ00_RS32980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZZ00_RS32980	COG0519	Catalyzes the synthesis of GMP from XMP
HZZ00_RS32995	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS33000	COG0515	serine threonine protein kinase
HZZ00_RS33005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_RS33015	COG0515	serine threonine protein kinase
HZZ00_RS33020	COG0515	serine threonine protein kinase
HZZ00_RS33025	COG0515	serine threonine protein kinase
HZZ00_RS33025	COG2815	serine threonine protein kinase
HZZ00_RS33035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZZ00_RS33050	COG0516	GMP reductase activity
HZZ00_RS33060	COG1595	DNA-templated transcription, initiation
HZZ00_RS33065	COG2197	response regulator
HZZ00_RS33075	COG0583	DNA-binding transcription factor activity
HZZ00_RS33085	COG4221	oxidoreductase activity
HZZ00_RS33100	COG0459	protein refolding
HZZ00_RS33110	COG0726	polysaccharide deacetylase
HZZ00_RS33115	COG0726	polysaccharide deacetylase
HZZ00_RS33130	COG1609	Transcriptional regulator
HZZ00_RS33135	COG1653	transport
HZZ00_RS33140	COG1175	transmembrane transport
HZZ00_RS33150	COG1472	Belongs to the glycosyl hydrolase 3 family
HZZ00_RS33165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZZ00_RS33185	COG0802	atpase or kinase
HZZ00_RS33195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZZ00_RS33205	COG0736	holo-[acyl-carrier-protein] synthase activity
HZZ00_RS33210	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS33215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZZ00_RS33220	COG1072	(Pantothenic acid kinase))
HZZ00_RS33230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZZ00_RS33235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZZ00_RS33240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZZ00_RS33250	COG0101	tRNA pseudouridine synthase activity
HZZ00_RS33255	COG0203	ribosomal protein L17
HZZ00_RS33260	COG0202	RNA polymerase activity
HZZ00_RS33265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZZ00_RS33270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZZ00_RS33275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZZ00_RS33280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZZ00_RS33290	COG0563	adenylate kinase activity
HZZ00_RS33300	COG0200	Binds to the 23S rRNA
HZZ00_RS33305	COG1841	ribosomal large subunit assembly
HZZ00_RS33310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZZ00_RS33315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZZ00_RS33320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZZ00_RS33325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZZ00_RS33330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZZ00_RS33335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZZ00_RS33340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZZ00_RS33345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZZ00_RS33350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZZ00_RS33355	COG0255	Belongs to the universal ribosomal protein uL29 family
HZZ00_RS33360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZZ00_RS33365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZZ00_RS33370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZZ00_RS33375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZZ00_RS33380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZZ00_RS33385	COG0089	rRNA binding
HZZ00_RS33390	COG0088	Forms part of the polypeptide exit tunnel
HZZ00_RS33395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZZ00_RS33400	COG0051	transcription antitermination factor activity, RNA binding
HZZ00_RS33460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZZ00_RS33465	COG0049	tRNA binding
HZZ00_RS33470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZZ00_RS33475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZZ00_RS33505	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZZ00_RS33510	COG0085	RNA polymerase activity
HZZ00_RS33520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZZ00_RS33530	COG0081	regulation of translation
HZZ00_RS33540	COG0250	Participates in transcription elongation, termination and antitermination
HZZ00_RS33555	COG0436	Aminotransferase
HZZ00_RS33560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZZ00_RS33565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZZ00_RS33600	COG2030	dehydratase
HZZ00_RS33605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZZ00_RS33625	COG0702	epimerase
HZZ00_RS33640	COG4191	Histidine kinase
HZZ00_RS33690	COG1666	GTP binding
HZZ00_RS33695	COG2261	transglycosylase associated protein
HZZ00_RS33710	COG0501	Belongs to the peptidase M48B family
HZZ00_RS33715	COG1007	ATP synthesis coupled electron transport
HZZ00_RS33725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZZ00_RS33730	COG0713	ATP synthesis coupled electron transport
HZZ00_RS33735	COG0839	Belongs to the complex I subunit 6 family
HZZ00_RS33740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS33745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZZ00_RS33750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS33755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS33760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS33780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZZ00_RS33780	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZZ00_RS33785	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZZ00_RS33810	COG3953	SLT domain
HZZ00_RS33810	COG5412	phage tail tape measure protein
HZZ00_RS33815	COG0561	phosphatase activity
HZZ00_RS33830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HZZ00_RS33835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HZZ00_RS33855	COG1007	ATP synthesis coupled electron transport
HZZ00_RS33865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZZ00_RS33870	COG0713	ATP synthesis coupled electron transport
HZZ00_RS33875	COG0839	Belongs to the complex I subunit 6 family
HZZ00_RS33880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS33885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZZ00_RS33890	COG1034	ATP synthesis coupled electron transport
HZZ00_RS33895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZZ00_RS33905	COG0649	NAD binding
HZZ00_RS33910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS33915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZZ00_RS33930	COG0242	peptide deformylase activity
HZZ00_RS33950	COG2226	methyltransferase
HZZ00_RS33960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HZZ00_RS33975	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HZZ00_RS33985	COG2226	methyltransferase
HZZ00_RS34000	COG3629	intracellular signal transduction
HZZ00_RS34040	COG1309	transcriptional regulator
HZZ00_RS34055	COG1573	uracil-dna glycosylase
HZZ00_RS34060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HZZ00_RS34070	COG0163	prenyltransferase activity
HZZ00_RS34075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZZ00_RS34080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZZ00_RS34125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZZ00_RS34130	COG1333	cytochrome c biogenesis protein
HZZ00_RS34135	COG0785	Cytochrome C biogenesis protein
HZZ00_RS34150	COG0406	alpha-ribazole phosphatase activity
HZZ00_RS34155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZZ00_RS34175	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS34195	COG2362	D-Aminopeptidase
HZZ00_RS34205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZZ00_RS34205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZZ00_RS34210	COG2205	protein histidine kinase activity
HZZ00_RS34225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS34230	COG1742	UPF0060 membrane protein
HZZ00_RS34255	COG1690	Belongs to the RtcB family
HZZ00_RS34275	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HZZ00_RS34280	COG0018	arginyl-trna synthetase
HZZ00_RS34320	COG2910	NAD(P)H-binding
HZZ00_RS34325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZZ00_RS34330	COG0113	porphobilinogen synthase activity
HZZ00_RS34345	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HZZ00_RS34370	COG1648	precorrin-2 dehydrogenase activity
HZZ00_RS34370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZZ00_RS34375	COG0181	hydroxymethylbilane synthase activity
HZZ00_RS34380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZZ00_RS34385	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HZZ00_RS34435	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZZ00_RS34440	COG2223	nitrite transmembrane transporter activity
HZZ00_RS34470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZZ00_RS34485	COG4991	sh3 domain protein
HZZ00_RS34490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZZ00_RS34490	COG0515	serine threonine protein kinase
HZZ00_RS34495	COG0129	dihydroxy-acid dehydratase activity
HZZ00_RS34505	COG1082	Xylose isomerase domain protein TIM barrel
HZZ00_RS34510	COG0248	Ppx GppA phosphatase
HZZ00_RS34530	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HZZ00_RS34540	COG1194	a g-specific adenine glycosylase
HZZ00_RS34545	COG1595	DNA-templated transcription, initiation
HZZ00_RS34555	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS34560	COG2205	protein histidine kinase activity
HZZ00_RS34580	COG0477	Major facilitator Superfamily
HZZ00_RS34590	COG0739	heme binding
HZZ00_RS34620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZZ00_RS34640	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZZ00_RS34650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZZ00_RS34655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZZ00_RS34665	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HZZ00_RS34680	COG2197	response regulator
HZZ00_RS34695	COG0649	NAD binding
HZZ00_RS34710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZZ00_RS34710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZZ00_RS34725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZZ00_RS34740	COG0302	gtp cyclohydrolase
HZZ00_RS34755	COG0037	tRNA processing
HZZ00_RS34765	COG2027	D-alanyl-D-alanine carboxypeptidase
HZZ00_RS34770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZZ00_RS34785	COG0393	Putative heavy-metal-binding
HZZ00_RS34790	COG0789	Transcriptional regulator
HZZ00_RS34795	COG0076	glutamate decarboxylase activity
HZZ00_RS34800	COG2318	DinB family
HZZ00_RS34805	COG1012	belongs to the aldehyde dehydrogenase family
HZZ00_RS34845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZZ00_RS34845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZZ00_RS34850	COG3903	Transcriptional regulator
HZZ00_RS34850	COG3629	intracellular signal transduction
HZZ00_RS34860	COG0673	inositol 2-dehydrogenase activity
HZZ00_RS34865	COG5297	Belongs to the glycosyl hydrolase family 6
HZZ00_RS34875	COG0604	alcohol dehydrogenase
HZZ00_RS34895	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HZZ00_RS34905	COG0406	alpha-ribazole phosphatase activity
HZZ00_RS34910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZZ00_RS35025	COG4974	Belongs to the 'phage' integrase family
HZZ00_RS35045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZZ00_RS35050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZZ00_RS35050	COG1754	DNA topoisomerase type I activity
HZZ00_RS35070	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZZ00_RS35075	COG2172	sigma factor antagonist activity
HZZ00_RS35080	COG1366	Belongs to the anti-sigma-factor antagonist family
HZZ00_RS35085	COG1111	helicase
HZZ00_RS35085	COG1205	dead DEAH box helicase
HZZ00_RS35145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZZ00_RS35160	COG2267	carboxylic ester hydrolase activity
HZZ00_RS35195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZZ00_RS35220	COG0003	Pfam Anion-transporting ATPase
HZZ00_RS35240	COG1408	metallophosphoesterase
HZZ00_RS35295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZZ00_RS35310	COG1937	Protein conserved in bacteria
HZZ00_RS35370	COG0583	DNA-binding transcription factor activity
HZZ00_RS35380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZZ00_RS35390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZZ00_RS35400	COG1309	transcriptional regulator
HZZ00_RS35415	COG1802	Transcriptional regulator
HZZ00_RS35420	COG4552	Acetyltransferase involved in intracellular survival and related
HZZ00_RS35430	COG1490	D-aminoacyl-tRNA deacylase activity
HZZ00_RS35445	COG3485	protocatechuate 3,4-dioxygenase
HZZ00_RS35470	COG2897	thiosulfate sulfurtransferase activity
HZZ00_RS35535	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS35540	COG1609	Transcriptional regulator
HZZ00_RS35545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZZ00_RS35555	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS35565	COG0456	acetyltransferase
HZZ00_RS35570	COG1725	Transcriptional regulator
HZZ00_RS35575	COG3842	ATPase activity
HZZ00_RS35585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZZ00_RS35615	COG1937	Protein conserved in bacteria
HZZ00_RS35625	COG0306	phosphate transporter
HZZ00_RS35630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZZ00_RS35650	COG0277	FAD linked oxidase domain protein
HZZ00_RS35655	COG0671	phosphoesterase, PA-phosphatase related
HZZ00_RS35660	COG0791	NLP P60 protein
HZZ00_RS35685	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS35690	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS35780	COG1252	NADH dehydrogenase
HZZ00_RS35810	COG0579	oxidoreductase
HZZ00_RS35815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZZ00_RS35840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZZ00_RS35840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZZ00_RS35875	COG0513	Belongs to the DEAD box helicase family
HZZ00_RS35920	COG1643	Atp-dependent helicase
HZZ00_RS35950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZZ00_RS35970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZZ00_RS35975	COG0047	phosphoribosylformylglycinamidine synthase activity
HZZ00_RS35980	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZZ00_RS36005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZZ00_RS36020	COG0151	Belongs to the GarS family
HZZ00_RS36060	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS36100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZZ00_RS36135	COG1191	sigma factor activity
HZZ00_RS36140	COG1191	sigma factor activity
HZZ00_RS36170	COG3467	pyridoxamine 5'-phosphate
HZZ00_RS36180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZZ00_RS36190	COG2205	protein histidine kinase activity
HZZ00_RS36195	COG0745	RESPONSE REGULATOR receiver
HZZ00_RS36235	COG0318	PFAM AMP-dependent synthetase and ligase
HZZ00_RS36240	COG1595	DNA-templated transcription, initiation
HZZ00_RS36310	COG0653	protein targeting
HZZ00_RS36330	COG0006	proline dipeptidase activity
HZZ00_RS36355	COG1999	signal sequence binding
HZZ00_RS36370	COG2837	iron assimilation
HZZ00_RS36380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZZ00_RS36385	COG0561	phosphatase activity
HZZ00_RS36410	COG1131	(ABC) transporter
HZZ00_RS36425	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HZZ00_RS36435	COG0561	phosphatase activity
HZZ00_RS36440	COG4988	ABC transporter
HZZ00_RS36445	COG1294	oxidase, subunit
HZZ00_RS36450	COG1271	oxidase subunit
HZZ00_RS36455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZZ00_RS36460	COG1609	Transcriptional regulator
HZZ00_RS36475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZZ00_RS36500	COG0662	Cupin 2, conserved barrel domain protein
HZZ00_RS36505	COG1950	PFAM Membrane protein of
HZZ00_RS36510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZZ00_RS36515	COG0626	cystathionine gamma-synthase activity
HZZ00_RS36540	COG2814	Major facilitator Superfamily
HZZ00_RS36565	COG0305	Participates in initiation and elongation during chromosome replication
HZZ00_RS36575	COG0359	binds to the 23S rRNA
HZZ00_RS36580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZZ00_RS36585	COG0629	single-stranded DNA binding
HZZ00_RS36590	COG0360	Binds together with S18 to 16S ribosomal RNA
HZZ00_RS36615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZZ00_RS36635	COG0617	tRNA 3'-terminal CCA addition
HZZ00_RS36660	COG1473	amidohydrolase
HZZ00_RS36685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZZ00_RS36690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZZ00_RS36700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZZ00_RS36710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZZ00_RS36725	COG1741	Belongs to the pirin family
HZZ00_RS36735	COG1960	acyl-CoA dehydrogenase activity
HZZ00_RS36740	COG1362	aminopeptidase activity
HZZ00_RS36775	COG2271	Major facilitator Superfamily
HZZ00_RS36845	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZZ00_RS36850	COG0022	dehydrogenase e1 component
HZZ00_RS36865	COG0515	serine threonine protein kinase
HZZ00_RS36870	COG0515	serine threonine protein kinase
HZZ00_RS36885	COG0604	alcohol dehydrogenase
HZZ00_RS36885	COG1028	Short-chain dehydrogenase reductase Sdr
HZZ00_RS36885	COG3321	synthase
HZZ00_RS36890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZZ00_RS36920	COG1522	sequence-specific DNA binding
HZZ00_RS36925	COG1309	transcriptional regulator
HZZ00_RS36930	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZZ00_RS36955	COG3396	Phenylacetate-CoA oxygenase
HZZ00_RS36960	COG3460	Phenylacetate-CoA oxygenase
HZZ00_RS36965	COG3396	Phenylacetate-CoA oxygenase
HZZ00_RS36970	COG2151	metal-sulfur cluster biosynthetic enzyme
HZZ00_RS36975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZZ00_RS37000	COG0477	Major facilitator Superfamily
HZZ00_RS37010	COG1716	ATPase activity
HZZ00_RS37015	COG1716	ATPase activity
HZZ00_RS37035	COG0515	serine threonine protein kinase
HZZ00_RS37040	COG3764	Sortase (surface protein transpeptidase)
HZZ00_RS37045	COG3764	Sortase (surface protein transpeptidase)
HZZ00_RS37070	COG0705	Rhomboid family
HZZ00_RS37110	COG0515	serine threonine protein kinase
HZZ00_RS37140	COG4249	Peptidase C14 caspase catalytic subunit p20
HZZ00_RS37140	COG2319	Wd-40 repeat
HZZ00_RS37170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZZ00_RS37175	COG0187	DNA topoisomerase II activity
HZZ00_RS37180	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HZZ00_RS37185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZZ00_RS37190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZZ00_RS37195	COG0592	DNA-directed DNA polymerase activity
HZZ00_RS37260	COG2188	Transcriptional regulator
HZZ00_RS37370	COG2188	Transcriptional regulator
HZZ00_RS37750	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HZZ00_RS37845	COG0629	single-stranded DNA binding
HZZ00_RS38000	COG0305	Participates in initiation and elongation during chromosome replication