locus-tag	class	description
DEH18_RS00010	COG0592	DNA-directed DNA polymerase activity
DEH18_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DEH18_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DEH18_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DEH18_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DEH18_RS00060	COG0515	serine threonine protein kinase
DEH18_RS00095	COG0705	Rhomboid family
DEH18_RS00110	COG3764	Sortase (surface protein transpeptidase)
DEH18_RS00125	COG3764	Sortase (surface protein transpeptidase)
DEH18_RS00130	COG3764	Sortase (surface protein transpeptidase)
DEH18_RS00135	COG0142	geranyltranstransferase activity
DEH18_RS00140	COG0515	serine threonine protein kinase
DEH18_RS00145	COG0768	penicillin binding
DEH18_RS00150	COG0772	Belongs to the SEDS family
DEH18_RS00160	COG1716	ATPase activity
DEH18_RS00165	COG1716	ATPase activity
DEH18_RS00175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DEH18_RS00180	COG1733	regulation of RNA biosynthetic process
DEH18_RS00195	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS00200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DEH18_RS00205	COG2151	metal-sulfur cluster biosynthetic enzyme
DEH18_RS00210	COG3396	Phenylacetate-CoA oxygenase
DEH18_RS00215	COG3460	Phenylacetate-CoA oxygenase
DEH18_RS00220	COG3396	Phenylacetate-CoA oxygenase
DEH18_RS00255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DEH18_RS00285	COG1522	sequence-specific DNA binding
DEH18_RS00300	COG0515	serine threonine protein kinase
DEH18_RS00305	COG0515	serine threonine protein kinase
DEH18_RS00325	COG0022	dehydrogenase e1 component
DEH18_RS00330	COG0508	dehydrogenase complex catalyzes the overall conversion of
DEH18_RS00365	COG2378	regulation of single-species biofilm formation
DEH18_RS00380	COG0561	phosphatase activity
DEH18_RS00385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DEH18_RS00395	COG2837	iron assimilation
DEH18_RS00400	COG2372	response to copper ion
DEH18_RS00410	COG1999	signal sequence binding
DEH18_RS00435	COG0006	proline dipeptidase activity
DEH18_RS00455	COG0653	protein targeting
DEH18_RS00470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DEH18_RS00480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DEH18_RS00515	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS00520	COG0784	Response regulator, receiver
DEH18_RS00540	COG0515	serine threonine protein kinase
DEH18_RS00560	COG0477	Major facilitator Superfamily
DEH18_RS00580	COG1191	sigma factor activity
DEH18_RS00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DEH18_RS00625	COG0758	DNA mediated transformation
DEH18_RS00630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DEH18_RS00665	COG1674	ftsk spoiiie
DEH18_RS00700	COG2205	protein histidine kinase activity
DEH18_RS00700	COG0784	Response regulator, receiver
DEH18_RS00715	COG0590	tRNA wobble adenosine to inosine editing
DEH18_RS00730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DEH18_RS00745	COG2234	aminopeptidase activity
DEH18_RS00755	COG0475	glutathione-regulated potassium exporter activity
DEH18_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS00785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DEH18_RS00800	COG0596	Alpha beta hydrolase
DEH18_RS00800	COG2945	thiolester hydrolase activity
DEH18_RS00805	COG1090	epimerase
DEH18_RS00815	COG1595	DNA-templated transcription, initiation
DEH18_RS00845	COG0583	DNA-binding transcription factor activity
DEH18_RS00890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DEH18_RS00895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DEH18_RS00905	COG0640	Transcriptional regulator
DEH18_RS00910	COG2304	oxidoreductase activity
DEH18_RS00955	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DEH18_RS01000	COG1408	metallophosphoesterase
DEH18_RS01010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DEH18_RS01020	COG0003	Pfam Anion-transporting ATPase
DEH18_RS01035	COG0251	oxidation-reduction process
DEH18_RS01045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DEH18_RS01075	COG2267	carboxylic ester hydrolase activity
DEH18_RS01090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DEH18_RS01155	COG1111	helicase
DEH18_RS01155	COG1205	dead DEAH box helicase
DEH18_RS01160	COG1366	Belongs to the anti-sigma-factor antagonist family
DEH18_RS01165	COG2172	sigma factor antagonist activity
DEH18_RS01170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DEH18_RS01185	COG1754	DNA topoisomerase type I activity
DEH18_RS01185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DEH18_RS01190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DEH18_RS01225	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DEH18_RS01245	COG3903	Transcriptional regulator
DEH18_RS01245	COG3629	intracellular signal transduction
DEH18_RS01250	COG0596	Alpha beta hydrolase
DEH18_RS01255	COG1472	Belongs to the glycosyl hydrolase 3 family
DEH18_RS01265	COG0277	FAD linked oxidase domain protein
DEH18_RS01280	COG1230	cation diffusion facilitator family transporter
DEH18_RS01290	COG0393	Putative heavy-metal-binding
DEH18_RS01300	COG0477	Major facilitator Superfamily
DEH18_RS01335	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS01360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DEH18_RS01400	COG0588	phosphoglycerate mutase activity
DEH18_RS01405	COG4585	Histidine kinase
DEH18_RS01410	COG2197	response regulator
DEH18_RS01425	COG5002	protein histidine kinase activity
DEH18_RS01430	COG0745	RESPONSE REGULATOR receiver
DEH18_RS01445	COG1329	Transcriptional regulator
DEH18_RS01450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DEH18_RS01455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DEH18_RS01465	COG0747	negative chemotaxis
DEH18_RS01480	COG3467	pyridoxamine 5'-phosphate
DEH18_RS01485	COG0215	cysteine-tRNA ligase activity
DEH18_RS01490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DEH18_RS01510	COG3842	ATPase activity
DEH18_RS01550	COG3345	alpha-galactosidase
DEH18_RS01565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DEH18_RS01590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DEH18_RS01600	COG1653	transport
DEH18_RS01610	COG1309	transcriptional regulator
DEH18_RS01615	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DEH18_RS01625	COG0463	Glycosyl transferase, family 2
DEH18_RS01640	COG1278	Cold shock
DEH18_RS01655	COG2207	Transcriptional regulator
DEH18_RS01660	COG2223	nitrite transmembrane transporter activity
DEH18_RS01705	COG1115	amino acid carrier protein
DEH18_RS01710	COG2813	Specifically methylates the guanine in position
DEH18_RS01720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DEH18_RS01725	COG1737	Transcriptional regulator
DEH18_RS01740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DEH18_RS01750	COG1309	transcriptional regulator
DEH18_RS01775	COG2814	Major facilitator Superfamily
DEH18_RS01795	COG0402	S-adenosylhomocysteine deaminase activity
DEH18_RS01835	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS01840	COG1061	Type III restriction enzyme res subunit
DEH18_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS01860	COG0583	DNA-binding transcription factor activity
DEH18_RS01870	COG2936	dipeptidyl-peptidase activity
DEH18_RS01875	COG1732	Glycine betaine
DEH18_RS01885	COG1174	glycine betaine transport
DEH18_RS01890	COG1174	glycine betaine transport
DEH18_RS01905	COG0456	acetyltransferase
DEH18_RS01905	COG3153	acetyltransferase
DEH18_RS01910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DEH18_RS01915	COG1120	ATPase activity
DEH18_RS01920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS01925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS01940	COG1278	Cold shock
DEH18_RS01950	COG0702	epimerase
DEH18_RS01955	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DEH18_RS01960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DEH18_RS01985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DEH18_RS01995	COG2252	PERMEase
DEH18_RS02005	COG1846	Transcriptional regulator
DEH18_RS02025	COG0667	Aldo Keto reductase
DEH18_RS02065	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DEH18_RS02075	COG0247	lactate metabolic process
DEH18_RS02075	COG0277	FAD linked oxidase domain protein
DEH18_RS02090	COG2207	Transcriptional regulator
DEH18_RS02105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DEH18_RS02120	COG1024	Enoyl-CoA hydratase
DEH18_RS02140	COG0259	pyridoxamine-phosphate oxidase activity
DEH18_RS02145	COG5002	protein histidine kinase activity
DEH18_RS02145	COG5001	Diguanylate cyclase
DEH18_RS02145	COG3447	MASE1 domain protein
DEH18_RS02150	COG4821	SIS domain
DEH18_RS02205	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS02215	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS02220	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS02265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DEH18_RS02270	COG1024	Enoyl-CoA hydratase
DEH18_RS02280	COG2072	flavoprotein involved in K transport
DEH18_RS02310	COG1309	transcriptional regulator
DEH18_RS02315	COG0515	serine threonine protein kinase
DEH18_RS02315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DEH18_RS02330	COG1024	Enoyl-CoA hydratase
DEH18_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS02390	COG0667	Aldo Keto reductase
DEH18_RS02410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DEH18_RS02435	COG1686	Belongs to the peptidase S11 family
DEH18_RS02495	COG1254	Belongs to the acylphosphatase family
DEH18_RS02500	COG0107	imidazoleglycerol-phosphate synthase activity
DEH18_RS02510	COG0604	alcohol dehydrogenase
DEH18_RS02515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DEH18_RS02585	COG0582	viral genome integration into host DNA
DEH18_RS02595	COG4585	Histidine kinase
DEH18_RS02600	COG0586	Pfam SNARE associated Golgi protein
DEH18_RS02605	COG1472	Belongs to the glycosyl hydrolase 3 family
DEH18_RS02610	COG0655	NAD(P)H dehydrogenase (quinone) activity
DEH18_RS02630	COG1349	DNA-binding transcription factor activity
DEH18_RS02635	COG1105	Belongs to the carbohydrate kinase PfkB family
DEH18_RS02640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DEH18_RS02640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DEH18_RS02640	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DEH18_RS02655	COG1970	mechanosensitive ion channel activity
DEH18_RS02665	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DEH18_RS02690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DEH18_RS02695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DEH18_RS02705	COG0315	cyclic pyranopterin monophosphate synthase activity
DEH18_RS02710	COG0521	Mo-molybdopterin cofactor biosynthetic process
DEH18_RS02715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DEH18_RS02750	COG0583	DNA-binding transcription factor activity
DEH18_RS02765	COG2076	Multidrug Resistance protein
DEH18_RS02785	COG0708	Exodeoxyribonuclease III
DEH18_RS02795	COG2072	flavoprotein involved in K transport
DEH18_RS02800	COG2267	carboxylic ester hydrolase activity
DEH18_RS02805	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS02815	COG0793	Belongs to the peptidase S41A family
DEH18_RS02815	COG4946	Tricorn protease homolog
DEH18_RS02820	COG2409	Drug exporters of the RND superfamily
DEH18_RS02850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DEH18_RS02855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DEH18_RS02865	COG0084	hydrolase, TatD family'
DEH18_RS02890	COG0442	prolyl-tRNA aminoacylation
DEH18_RS02900	COG0488	(ABC) transporter
DEH18_RS02945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DEH18_RS02950	COG2197	response regulator
DEH18_RS02970	COG2197	response regulator
DEH18_RS02980	COG1846	Transcriptional regulator
DEH18_RS02985	COG4106	trans-aconitate 2-methyltransferase activity
DEH18_RS03000	COG1278	Cold shock
DEH18_RS03005	COG0513	Belongs to the DEAD box helicase family
DEH18_RS03020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DEH18_RS03050	COG0193	aminoacyl-tRNA hydrolase activity
DEH18_RS03055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DEH18_RS03060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DEH18_RS03065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DEH18_RS03080	COG4585	Histidine kinase
DEH18_RS03105	COG1316	TRANSCRIPTIONal
DEH18_RS03150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DEH18_RS03165	COG0789	Transcriptional regulator
DEH18_RS03170	COG0657	acetylesterase activity
DEH18_RS03220	COG0148	phosphopyruvate hydratase activity
DEH18_RS03260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DEH18_RS03265	COG0577	efflux transmembrane transporter activity
DEH18_RS03270	COG1136	(ABC) transporter
DEH18_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS03315	COG1309	transcriptional regulator
DEH18_RS03330	COG2259	Doxx family
DEH18_RS03355	COG0183	Belongs to the thiolase family
DEH18_RS03375	COG1846	Transcriptional regulator
DEH18_RS03390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DEH18_RS03395	COG0477	Major facilitator Superfamily
DEH18_RS03410	COG1175	transmembrane transport
DEH18_RS03415	COG1653	transport
DEH18_RS03425	COG0477	Major facilitator Superfamily
DEH18_RS03440	COG0778	Nitroreductase
DEH18_RS03450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DEH18_RS03485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DEH18_RS03490	COG0019	diaminopimelate decarboxylase activity
DEH18_RS03495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DEH18_RS03510	COG1228	amidohydrolase
DEH18_RS03535	COG0477	Major facilitator Superfamily
DEH18_RS03540	COG1191	sigma factor activity
DEH18_RS03580	COG3104	oligopeptide transport
DEH18_RS03585	COG0745	RESPONSE REGULATOR receiver
DEH18_RS03590	COG5002	protein histidine kinase activity
DEH18_RS03650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DEH18_RS03660	COG1316	TRANSCRIPTIONal
DEH18_RS03665	COG1607	acyl-coa hydrolase
DEH18_RS03685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS03705	COG1316	TRANSCRIPTIONal
DEH18_RS03760	COG0778	Nitroreductase
DEH18_RS03760	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DEH18_RS03800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DEH18_RS03805	COG2835	tetraacyldisaccharide 4'-kinase activity
DEH18_RS03825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DEH18_RS03825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DEH18_RS03825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DEH18_RS03830	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DEH18_RS03870	COG0714	Associated with various cellular activities
DEH18_RS03890	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DEH18_RS03895	COG0745	RESPONSE REGULATOR receiver
DEH18_RS03900	COG5002	protein histidine kinase activity
DEH18_RS03905	COG0823	Involved in the tonB-independent uptake of proteins
DEH18_RS03915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DEH18_RS03920	COG2197	response regulator
DEH18_RS03935	COG0653	protein targeting
DEH18_RS03960	COG2902	Dehydrogenase
DEH18_RS03970	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS03985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DEH18_RS04000	COG0673	inositol 2-dehydrogenase activity
DEH18_RS04035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DEH18_RS04055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DEH18_RS04065	COG0395	ABC-type sugar transport system, permease component
DEH18_RS04090	COG0515	serine threonine protein kinase
DEH18_RS04095	COG0515	serine threonine protein kinase
DEH18_RS04100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DEH18_RS04115	COG2884	Cell division ATP-binding protein ftsE
DEH18_RS04120	COG2177	Part of the ABC transporter FtsEX involved in
DEH18_RS04125	COG0793	Belongs to the peptidase S41A family
DEH18_RS04130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DEH18_RS04150	COG0583	DNA-binding transcription factor activity
DEH18_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS04170	COG1309	transcriptional regulator
DEH18_RS04180	COG0477	Major facilitator Superfamily
DEH18_RS04190	COG3973	AAA domain
DEH18_RS04200	COG1278	Cold shock
DEH18_RS04210	COG0776	regulation of translation
DEH18_RS04220	COG2188	Transcriptional regulator
DEH18_RS04230	COG1178	ABC-type Fe3 transport system permease component
DEH18_RS04235	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DEH18_RS04240	COG3842	ATPase activity
DEH18_RS04245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DEH18_RS04250	COG1678	Uncharacterized ACR, COG1678
DEH18_RS04305	COG3511	phospholipase C
DEH18_RS04310	COG2362	D-Aminopeptidase
DEH18_RS04320	COG1653	transport
DEH18_RS04330	COG0395	ABC-type sugar transport system, permease component
DEH18_RS04335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DEH18_RS04350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DEH18_RS04380	COG3209	COG3209 Rhs family protein
DEH18_RS04400	COG0583	DNA-binding transcription factor activity
DEH18_RS04410	COG2855	membrane
DEH18_RS04435	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DEH18_RS04440	COG0277	FAD linked oxidase domain protein
DEH18_RS04475	COG1335	isochorismatase
DEH18_RS04485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DEH18_RS04495	COG1113	amino acid transport
DEH18_RS04525	COG1234	tRNA 3'-trailer cleavage
DEH18_RS04530	COG1263	PTS System
DEH18_RS04530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DEH18_RS04535	COG1263	PTS System
DEH18_RS04535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DEH18_RS04540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DEH18_RS04540	COG1263	PTS System
DEH18_RS04545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DEH18_RS04555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DEH18_RS04560	COG2304	oxidoreductase activity
DEH18_RS04565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS04585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DEH18_RS04625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DEH18_RS04630	COG2076	Multidrug Resistance protein
DEH18_RS04635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DEH18_RS04650	COG1131	(ABC) transporter
DEH18_RS04660	COG2733	membrane
DEH18_RS04675	COG0706	membrane insertase activity
DEH18_RS04680	COG0179	Fumarylacetoacetate (FAA) hydrolase
DEH18_RS04685	COG0673	inositol 2-dehydrogenase activity
DEH18_RS04690	COG2188	Transcriptional regulator
DEH18_RS04695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS04735	COG2130	NADP-dependent
DEH18_RS04760	COG3397	chitin binding
DEH18_RS04780	COG1126	abc transporter atp-binding protein
DEH18_RS04785	COG0765	amino acid transport
DEH18_RS04790	COG0765	amino acid transport
DEH18_RS04805	COG0154	amidase activity
DEH18_RS04810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DEH18_RS04820	COG3473	Maleate cis-trans isomerase
DEH18_RS04825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS04890	COG0745	RESPONSE REGULATOR receiver
DEH18_RS04900	COG3979	chitinase
DEH18_RS04910	COG0739	heme binding
DEH18_RS04920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DEH18_RS04925	COG4977	sequence-specific DNA binding
DEH18_RS04940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DEH18_RS04960	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS04975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DEH18_RS04980	COG1309	transcriptional regulator
DEH18_RS04985	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS04990	COG1946	Acyl-CoA thioesterase
DEH18_RS05020	COG1609	Transcriptional regulator
DEH18_RS05030	COG0673	inositol 2-dehydrogenase activity
DEH18_RS05045	COG1869	D-ribose catabolic process
DEH18_RS05050	COG1879	ABC-type sugar transport system periplasmic component
DEH18_RS05055	COG1172	Belongs to the binding-protein-dependent transport system permease family
DEH18_RS05060	COG1129	ABC transporter
DEH18_RS05065	COG1609	Transcriptional regulator
DEH18_RS05070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DEH18_RS05115	COG3962	Belongs to the TPP enzyme family
DEH18_RS05130	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS05235	COG2226	methyltransferase
DEH18_RS05250	COG2208	phosphoserine phosphatase activity
DEH18_RS05250	COG2770	Histidine kinase
DEH18_RS05255	COG2197	response regulator
DEH18_RS05270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DEH18_RS05290	COG2197	response regulator
DEH18_RS05295	COG2197	response regulator
DEH18_RS05300	COG4585	Histidine kinase
DEH18_RS05330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DEH18_RS05350	COG1136	(ABC) transporter
DEH18_RS05370	COG3655	Transcriptional regulator
DEH18_RS05445	COG2154	pterin-4-alpha-carbinolamine dehydratase
DEH18_RS05450	COG1129	ABC transporter
DEH18_RS05465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DEH18_RS05470	COG0512	Glutamine amidotransferase of anthranilate synthase
DEH18_RS05475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DEH18_RS05480	COG0134	indole-3-glycerol-phosphate synthase activity
DEH18_RS05485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DEH18_RS05500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DEH18_RS05510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DEH18_RS05515	COG0402	S-adenosylhomocysteine deaminase activity
DEH18_RS05520	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS05530	COG2124	cytochrome p450
DEH18_RS05550	COG2205	protein histidine kinase activity
DEH18_RS05555	COG0745	RESPONSE REGULATOR receiver
DEH18_RS05565	COG2755	lipolytic protein G-D-S-L family
DEH18_RS05565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DEH18_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS05605	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS05630	COG0629	single-stranded DNA binding
DEH18_RS05655	COG1136	(ABC) transporter
DEH18_RS05670	COG2346	COG2346, Truncated hemoglobins
DEH18_RS05675	COG0842	Transport permease protein
DEH18_RS05680	COG1131	(ABC) transporter
DEH18_RS05695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DEH18_RS05730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DEH18_RS05735	COG0668	transmembrane transport
DEH18_RS05745	COG3291	Pkd domain containing protein
DEH18_RS05745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DEH18_RS05775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS05790	COG0583	DNA-binding transcription factor activity
DEH18_RS05800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DEH18_RS05805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DEH18_RS05810	COG1113	amino acid transport
DEH18_RS05820	COG1113	amino acid transport
DEH18_RS05840	COG0515	serine threonine protein kinase
DEH18_RS05865	COG0577	efflux transmembrane transporter activity
DEH18_RS05865	COG1136	(ABC) transporter
DEH18_RS05875	COG2239	Acts as a magnesium transporter
DEH18_RS05880	COG3594	Acyltransferase
DEH18_RS05900	COG0544	peptidyl-prolyl cis-trans isomerase activity
DEH18_RS05905	COG0740	serine-type endopeptidase activity
DEH18_RS05910	COG0740	serine-type endopeptidase activity
DEH18_RS05915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DEH18_RS05935	COG0525	valine-tRNA ligase activity
DEH18_RS05955	COG1653	transport
DEH18_RS05960	COG0285	dihydrofolate synthase activity
DEH18_RS05970	COG0105	UTP biosynthetic process
DEH18_RS05975	COG1077	Cell shape determining protein MreB Mrl
DEH18_RS05990	COG0768	penicillin binding
DEH18_RS05995	COG0772	Belongs to the SEDS family
DEH18_RS06025	COG1530	ribonuclease E activity
DEH18_RS06030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DEH18_RS06035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DEH18_RS06040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DEH18_RS06085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DEH18_RS06095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DEH18_RS06110	COG0501	Belongs to the peptidase M48B family
DEH18_RS06120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DEH18_RS06155	COG5650	phosphatidylinositol metabolic process
DEH18_RS06165	COG0495	leucyl-tRNA aminoacylation
DEH18_RS06175	COG1307	EDD domain protein, DegV family
DEH18_RS06190	COG0268	Binds directly to 16S ribosomal RNA
DEH18_RS06195	COG0481	GTPase activity
DEH18_RS06220	COG1420	regulation of RNA biosynthetic process
DEH18_RS06225	COG0484	heat shock protein binding
DEH18_RS06240	COG0537	adenosine 5'-monophosphoramidase activity
DEH18_RS06245	COG1234	tRNA 3'-trailer cleavage
DEH18_RS06250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DEH18_RS06260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DEH18_RS06275	COG2315	Protein conserved in bacteria
DEH18_RS06285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DEH18_RS06300	COG1486	melibiose metabolic process
DEH18_RS06305	COG4948	Mandelate Racemase Muconate Lactonizing
DEH18_RS06315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DEH18_RS06330	COG2723	6-phospho-beta-galactosidase activity
DEH18_RS06340	COG0778	Nitroreductase
DEH18_RS06345	COG1381	Involved in DNA repair and RecF pathway recombination
DEH18_RS06350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DEH18_RS06390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DEH18_RS06395	COG1121	(ABC) transporter
DEH18_RS06405	COG0423	glycine-tRNA ligase activity
DEH18_RS06410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS06415	COG0640	Transcriptional regulator
DEH18_RS06420	COG1902	pentaerythritol trinitrate reductase activity
DEH18_RS06425	COG1695	Transcriptional regulator
DEH18_RS06455	COG0477	Major facilitator Superfamily
DEH18_RS06465	COG0477	Major facilitator Superfamily
DEH18_RS06470	COG1846	Transcriptional regulator
DEH18_RS06485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DEH18_RS06485	COG0574	Belongs to the PEP-utilizing enzyme family
DEH18_RS06495	COG4565	transcriptional regulatory protein
DEH18_RS06505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DEH18_RS06515	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS06520	COG0583	DNA-binding transcription factor activity
DEH18_RS06545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DEH18_RS06555	COG0028	Belongs to the TPP enzyme family
DEH18_RS06560	COG0358	DNA primase activity
DEH18_RS06565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DEH18_RS06585	COG1070	Carbohydrate kinase
DEH18_RS06590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DEH18_RS06640	COG1793	dna ligase
DEH18_RS06640	COG3285	dna ligase
DEH18_RS06645	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DEH18_RS06675	COG4981	capsule polysaccharide biosynthetic process
DEH18_RS06680	COG0500	methyltransferase
DEH18_RS06705	COG1846	Transcriptional regulator
DEH18_RS06710	COG2130	NADP-dependent
DEH18_RS06715	COG1764	response to oxidative stress
DEH18_RS06735	COG2084	Dehydrogenase
DEH18_RS06740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS06745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DEH18_RS06750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DEH18_RS06775	COG0789	Transcriptional regulator
DEH18_RS06790	COG2197	response regulator
DEH18_RS06810	COG1309	transcriptional regulator
DEH18_RS06815	COG0477	Major facilitator Superfamily
DEH18_RS06825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DEH18_RS06870	COG1358	cellular component organization or biogenesis
DEH18_RS06935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DEH18_RS06960	COG2124	cytochrome p450
DEH18_RS06965	COG0183	Belongs to the thiolase family
DEH18_RS06970	COG2201	protein-glutamate methylesterase activity
DEH18_RS06975	COG0586	Pfam SNARE associated Golgi protein
DEH18_RS06985	COG1309	transcriptional regulator
DEH18_RS06995	COG3845	ABC transporter
DEH18_RS07010	COG1657	PFAM Prenyltransferase squalene oxidase
DEH18_RS07035	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DEH18_RS07055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DEH18_RS07060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DEH18_RS07065	COG1984	allophanate hydrolase subunit 2
DEH18_RS07070	COG1309	transcriptional regulator
DEH18_RS07075	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS07090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS07100	COG0860	N-Acetylmuramoyl-L-alanine amidase
DEH18_RS07105	COG3510	cephalosporin hydroxylase
DEH18_RS07115	COG2197	response regulator
DEH18_RS07120	COG4585	Histidine kinase
DEH18_RS07150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DEH18_RS07160	COG0328	RNA-DNA hybrid ribonuclease activity
DEH18_RS07160	COG0406	alpha-ribazole phosphatase activity
DEH18_RS07165	COG0800	Aldolase
DEH18_RS07170	COG3022	response to hydroperoxide
DEH18_RS07175	COG0277	FAD linked oxidase domain protein
DEH18_RS07215	COG4585	Histidine kinase
DEH18_RS07250	COG1131	(ABC) transporter
DEH18_RS07280	COG2815	serine threonine protein kinase
DEH18_RS07280	COG0515	serine threonine protein kinase
DEH18_RS07350	COG4221	oxidoreductase activity
DEH18_RS07355	COG2814	Major facilitator Superfamily
DEH18_RS07360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DEH18_RS07370	COG1834	amidinotransferase
DEH18_RS07395	COG1120	ATPase activity
DEH18_RS07400	COG1131	(ABC) transporter
DEH18_RS07410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DEH18_RS07420	COG0789	Transcriptional regulator
DEH18_RS07430	COG1690	Belongs to the RtcB family
DEH18_RS07465	COG1175	transmembrane transport
DEH18_RS07505	COG1309	transcriptional regulator
DEH18_RS07525	COG1994	Peptidase M50
DEH18_RS07555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DEH18_RS07560	COG0477	Major facilitator Superfamily
DEH18_RS07575	COG2814	Major facilitator Superfamily
DEH18_RS07585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DEH18_RS07585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DEH18_RS07590	COG2132	Multicopper oxidase
DEH18_RS07655	COG0174	glutamine synthetase
DEH18_RS07660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DEH18_RS07670	COG1609	Transcriptional regulator
DEH18_RS07675	COG0366	Alpha amylase catalytic
DEH18_RS07685	COG1175	transmembrane transport
DEH18_RS07695	COG0366	Alpha amylase catalytic
DEH18_RS07705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DEH18_RS07715	COG2197	response regulator
DEH18_RS07720	COG1309	transcriptional regulator
DEH18_RS07740	COG2197	response regulator
DEH18_RS07765	COG2890	protein-(glutamine-N5) methyltransferase activity
DEH18_RS07790	COG0321	lipoyl(octanoyl) transferase activity
DEH18_RS07795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DEH18_RS07810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DEH18_RS07900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DEH18_RS07905	COG2838	Isocitrate dehydrogenase
DEH18_RS07940	COG2197	response regulator
DEH18_RS07950	COG0577	efflux transmembrane transporter activity
DEH18_RS07950	COG1136	(ABC) transporter
DEH18_RS07960	COG0395	ABC-type sugar transport system, permease component
DEH18_RS07975	COG1846	Transcriptional regulator
DEH18_RS07975	COG1940	carbohydrate kinase activity
DEH18_RS08050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DEH18_RS08055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS08065	COG1120	ATPase activity
DEH18_RS08070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS08105	COG2378	regulation of single-species biofilm formation
DEH18_RS08110	COG0733	neurotransmitter:sodium symporter activity
DEH18_RS08120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DEH18_RS08130	COG0508	dehydrogenase complex catalyzes the overall conversion of
DEH18_RS08135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DEH18_RS08140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DEH18_RS08145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DEH18_RS08150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DEH18_RS08150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DEH18_RS08155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DEH18_RS08205	COG2197	response regulator
DEH18_RS08210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DEH18_RS08220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DEH18_RS08245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DEH18_RS08250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DEH18_RS08270	COG1845	cytochrome c oxidase, subunit III
DEH18_RS08275	COG2010	Cytochrome c
DEH18_RS08280	COG0723	plastoquinol--plastocyanin reductase activity
DEH18_RS08285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DEH18_RS08290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DEH18_RS08325	COG1070	Carbohydrate kinase
DEH18_RS08330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DEH18_RS08335	COG1757	Na H antiporter
DEH18_RS08340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DEH18_RS08355	COG1929	Belongs to the glycerate kinase type-1 family
DEH18_RS08365	COG0745	RESPONSE REGULATOR receiver
DEH18_RS08445	COG0003	Pfam Anion-transporting ATPase
DEH18_RS08455	COG1940	carbohydrate kinase activity
DEH18_RS08465	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DEH18_RS08495	COG2197	response regulator
DEH18_RS08500	COG0205	6-phosphofructokinase activity
DEH18_RS08505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DEH18_RS08515	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DEH18_RS08525	COG2193	ferroxidase activity
DEH18_RS08535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DEH18_RS08545	COG2815	serine threonine protein kinase
DEH18_RS08545	COG0515	serine threonine protein kinase
DEH18_RS08555	COG2022	thiamine diphosphate biosynthetic process
DEH18_RS08565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS08565	COG2022	thiamine diphosphate biosynthetic process
DEH18_RS08580	COG0352	thiamine-phosphate diphosphorylase activity
DEH18_RS08595	COG1233	COG1233 Phytoene dehydrogenase and related
DEH18_RS08610	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DEH18_RS08620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS08650	COG0275	rRNA processing
DEH18_RS08665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DEH18_RS08675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DEH18_RS08680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DEH18_RS08690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DEH18_RS08695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DEH18_RS08700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DEH18_RS08715	COG1799	cell septum assembly
DEH18_RS08725	COG3599	regulation of cell shape
DEH18_RS08735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DEH18_RS08740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DEH18_RS08745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DEH18_RS08795	COG0587	DNA-directed DNA polymerase activity
DEH18_RS08800	COG1432	Conserved Protein
DEH18_RS08820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DEH18_RS08835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DEH18_RS08840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DEH18_RS08845	COG0131	Imidazoleglycerol-phosphate dehydratase
DEH18_RS08850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DEH18_RS08855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DEH18_RS08860	COG0251	oxidation-reduction process
DEH18_RS08865	COG0107	imidazoleglycerol-phosphate synthase activity
DEH18_RS08870	COG1120	ATPase activity
DEH18_RS08875	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DEH18_RS08890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DEH18_RS08895	COG1053	succinate dehydrogenase
DEH18_RS08915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DEH18_RS08920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DEH18_RS08940	COG0134	indole-3-glycerol-phosphate synthase activity
DEH18_RS08950	COG0133	tryptophan synthase activity
DEH18_RS08955	COG0159	tryptophan synthase activity
DEH18_RS08965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DEH18_RS08970	COG2111	Na H antiporter
DEH18_RS08970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DEH18_RS08975	COG1006	Multisubunit Na H antiporter MnhC subunit
DEH18_RS08995	COG1320	monovalent cation:proton antiporter activity
DEH18_RS09005	COG2301	Belongs to the HpcH HpaI aldolase family
DEH18_RS09010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DEH18_RS09030	COG1397	ADP-ribosylglycohydrolase
DEH18_RS09070	COG0069	glutamate synthase activity
DEH18_RS09070	COG0067	glutamate synthase
DEH18_RS09070	COG0070	glutamate synthase
DEH18_RS09080	COG0154	amidase activity
DEH18_RS09110	COG0326	Molecular chaperone. Has ATPase activity
DEH18_RS09140	COG3585	molybdate ion transport
DEH18_RS09215	COG1470	cell adhesion involved in biofilm formation
DEH18_RS09215	COG0366	Alpha amylase catalytic
DEH18_RS09220	COG4977	sequence-specific DNA binding
DEH18_RS09220	COG1917	Cupin 2, conserved barrel domain protein
DEH18_RS09225	COG0287	Prephenate dehydrogenase
DEH18_RS09225	COG1605	Chorismate mutase
DEH18_RS09235	COG0181	hydroxymethylbilane synthase activity
DEH18_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS09315	COG0410	ABC transporter
DEH18_RS09320	COG0411	ABC transporter
DEH18_RS09340	COG2050	protein possibly involved in aromatic compounds catabolism
DEH18_RS09370	COG1643	Atp-dependent helicase
DEH18_RS09375	COG2226	methyltransferase
DEH18_RS09395	COG0237	dephospho-CoA kinase activity
DEH18_RS09410	COG0656	L-ascorbic acid biosynthetic process
DEH18_RS09415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DEH18_RS09460	COG2208	phosphoserine phosphatase activity
DEH18_RS09460	COG2770	Histidine kinase
DEH18_RS09465	COG2814	Major facilitator Superfamily
DEH18_RS09475	COG0584	glycerophosphoryl diester phosphodiesterase
DEH18_RS09480	COG0556	nucleotide-excision repair
DEH18_RS09495	COG0861	Integral membrane protein TerC family
DEH18_RS09540	COG0322	excinuclease ABC activity
DEH18_RS09545	COG1660	Displays ATPase and GTPase activities
DEH18_RS09550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DEH18_RS09555	COG1481	regulation of sporulation
DEH18_RS09560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DEH18_RS09565	COG0126	phosphoglycerate kinase activity
DEH18_RS09570	COG0149	triose-phosphate isomerase activity
DEH18_RS09575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DEH18_RS09585	COG0166	Belongs to the GPI family
DEH18_RS09595	COG0363	glucosamine-6-phosphate deaminase activity
DEH18_RS09610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DEH18_RS09620	COG0109	protoheme IX farnesyltransferase activity
DEH18_RS09640	COG1131	(ABC) transporter
DEH18_RS09655	COG0719	Fe-S assembly protein
DEH18_RS09665	COG0396	ATPase activity
DEH18_RS09670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DEH18_RS09675	COG0822	iron-sulfur transferase activity
DEH18_RS09685	COG2076	Multidrug Resistance protein
DEH18_RS09690	COG3226	Transcriptional regulator
DEH18_RS09695	COG2171	N-acyltransferase activity
DEH18_RS09715	COG2391	methyltransferase activity
DEH18_RS09745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS09755	COG2261	transglycosylase associated protein
DEH18_RS09760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DEH18_RS09765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DEH18_RS09775	COG0768	penicillin binding
DEH18_RS09785	COG2814	Major facilitator Superfamily
DEH18_RS09790	COG2197	response regulator
DEH18_RS09795	COG4585	Histidine kinase
DEH18_RS09805	COG1414	Transcriptional regulator
DEH18_RS09815	COG4552	Acetyltransferase involved in intracellular survival and related
DEH18_RS09825	COG5285	phytanoyl-CoA dioxygenase
DEH18_RS09830	COG1917	Cupin 2, conserved barrel domain protein
DEH18_RS09835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DEH18_RS09840	COG0456	acetyltransferase
DEH18_RS09850	COG3795	YCII-related domain
DEH18_RS09855	COG0825	malonyl-CoA metabolic process
DEH18_RS09855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DEH18_RS09880	COG1797	cobyrinic acid a,c-diamide synthase activity
DEH18_RS09895	COG1492	cobalamin metabolic process
DEH18_RS09900	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DEH18_RS09925	COG0488	(ABC) transporter
DEH18_RS09970	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS09980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DEH18_RS09990	COG1404	Belongs to the peptidase S8 family
DEH18_RS10000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DEH18_RS10005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DEH18_RS10020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DEH18_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS10030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DEH18_RS10035	COG2186	Transcriptional regulator
DEH18_RS10040	COG2807	transmembrane transport
DEH18_RS10060	COG1716	ATPase activity
DEH18_RS10060	COG0842	Transport permease protein
DEH18_RS10060	COG1131	(ABC) transporter
DEH18_RS10075	COG2197	response regulator
DEH18_RS10095	COG1119	ATPase activity
DEH18_RS10115	COG1881	PFAM PEBP family protein
DEH18_RS10130	COG2094	Belongs to the DNA glycosylase MPG family
DEH18_RS10165	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DEH18_RS10180	COG0647	UMP catabolic process
DEH18_RS10195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS10200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS10205	COG1120	ATPase activity
DEH18_RS10220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DEH18_RS10225	COG0497	DNA recombination
DEH18_RS10230	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS10250	COG3387	PFAM Glycoside hydrolase 15-related
DEH18_RS10255	COG0504	CTP synthase activity
DEH18_RS10260	COG0494	nUDIX hydrolase
DEH18_RS10270	COG0686	Belongs to the AlaDH PNT family
DEH18_RS10285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DEH18_RS10290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DEH18_RS10295	COG1187	pseudouridine synthase activity
DEH18_RS10310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DEH18_RS10320	COG1160	GTP binding
DEH18_RS10335	COG3583	domain protein
DEH18_RS10340	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS10365	COG0477	Major facilitator Superfamily
DEH18_RS10370	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS10375	COG1799	cell septum assembly
DEH18_RS10385	COG0330	HflC and HflK could
DEH18_RS10415	COG0587	DNA-directed DNA polymerase activity
DEH18_RS10440	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DEH18_RS10465	COG1725	Transcriptional regulator
DEH18_RS10510	COG1215	transferase activity, transferring glycosyl groups
DEH18_RS10515	COG0463	Glycosyl transferase, family 2
DEH18_RS10540	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DEH18_RS10545	COG2851	Citrate transporter
DEH18_RS10585	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS10605	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS10610	COG3173	Aminoglycoside phosphotransferase
DEH18_RS10615	COG3265	gluconokinase activity
DEH18_RS10625	COG2149	membrane
DEH18_RS10630	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DEH18_RS10715	COG1285	pathogenesis
DEH18_RS10725	COG0395	ABC-type sugar transport system, permease component
DEH18_RS10730	COG3833	ABC-type maltose transport systems, permease component
DEH18_RS10740	COG0740	serine-type endopeptidase activity
DEH18_RS10745	COG3226	Transcriptional regulator
DEH18_RS10750	COG0477	Major facilitator Superfamily
DEH18_RS10770	COG0739	heme binding
DEH18_RS10775	COG3250	beta-galactosidase activity
DEH18_RS10785	COG1316	TRANSCRIPTIONal
DEH18_RS10795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DEH18_RS10800	COG0640	Transcriptional regulator
DEH18_RS10810	COG1819	glycosyl
DEH18_RS10825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DEH18_RS10830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DEH18_RS10830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DEH18_RS10850	COG0395	ABC-type sugar transport system, permease component
DEH18_RS10855	COG1175	transmembrane transport
DEH18_RS10880	COG1175	transmembrane transport
DEH18_RS10885	COG0395	ABC-type sugar transport system, permease component
DEH18_RS10890	COG3842	ATPase activity
DEH18_RS10895	COG0613	PHP domain protein
DEH18_RS10900	COG2814	Major facilitator Superfamily
DEH18_RS10910	COG0383	alpha-mannosidase activity
DEH18_RS10935	COG3408	Glycogen debranching enzyme
DEH18_RS10935	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DEH18_RS10965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DEH18_RS10980	COG2890	protein-(glutamine-N5) methyltransferase activity
DEH18_RS10990	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS11030	COG0477	Major facilitator Superfamily
DEH18_RS11035	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS11090	COG1846	Transcriptional regulator
DEH18_RS11095	COG1595	DNA-templated transcription, initiation
DEH18_RS11100	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DEH18_RS11110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DEH18_RS11130	COG2124	cytochrome p450
DEH18_RS11145	COG0148	phosphopyruvate hydratase activity
DEH18_RS11150	COG1113	amino acid transport
DEH18_RS11185	COG4221	oxidoreductase activity
DEH18_RS11210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS11240	COG0667	Aldo Keto reductase
DEH18_RS11245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS11255	COG0598	Magnesium transport protein CorA
DEH18_RS11260	COG0406	alpha-ribazole phosphatase activity
DEH18_RS11275	COG0215	cysteine-tRNA ligase activity
DEH18_RS11285	COG4948	Mandelate Racemase Muconate Lactonizing
DEH18_RS11305	COG1172	Belongs to the binding-protein-dependent transport system permease family
DEH18_RS11310	COG2186	Transcriptional regulator
DEH18_RS11320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DEH18_RS11325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DEH18_RS11330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DEH18_RS11335	COG1414	Transcriptional regulator
DEH18_RS11340	COG0646	methionine synthase
DEH18_RS11340	COG1410	methionine synthase
DEH18_RS11350	COG0747	negative chemotaxis
DEH18_RS11355	COG2197	response regulator
DEH18_RS11365	COG0517	IMP dehydrogenase activity
DEH18_RS11365	COG1994	Peptidase M50
DEH18_RS11380	COG1222	aaa ATPase
DEH18_RS11385	COG4122	O-methyltransferase activity
DEH18_RS11395	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DEH18_RS11400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DEH18_RS11405	COG1609	Transcriptional regulator
DEH18_RS11415	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DEH18_RS11430	COG2378	regulation of single-species biofilm formation
DEH18_RS11445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DEH18_RS11450	COG0805	protein transport
DEH18_RS11470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DEH18_RS11475	COG4175	Glycine betaine
DEH18_RS11475	COG0517	IMP dehydrogenase activity
DEH18_RS11480	COG4176	ABC-type proline glycine betaine transport system permease component
DEH18_RS11510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DEH18_RS11515	COG0531	amino acid
DEH18_RS11520	COG2186	Transcriptional regulator
DEH18_RS11530	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS11555	COG1404	Belongs to the peptidase S8 family
DEH18_RS11570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DEH18_RS11580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DEH18_RS11585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DEH18_RS11590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DEH18_RS11595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DEH18_RS11600	COG5002	protein histidine kinase activity
DEH18_RS11605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DEH18_RS11610	COG0072	phenylalanine-tRNA ligase activity
DEH18_RS11610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DEH18_RS11620	COG0477	Major facilitator Superfamily
DEH18_RS11650	COG0667	Aldo Keto reductase
DEH18_RS11655	COG2226	methyltransferase
DEH18_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS11665	COG1959	2 iron, 2 sulfur cluster binding
DEH18_RS11670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DEH18_RS11675	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DEH18_RS11680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DEH18_RS11685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DEH18_RS11690	COG1438	arginine binding
DEH18_RS11715	COG3189	MarR family transcriptional regulator
DEH18_RS11720	COG0137	argininosuccinate synthase activity
DEH18_RS11725	COG0165	Argininosuccinate lyase
DEH18_RS11745	COG0477	Major facilitator Superfamily
DEH18_RS11750	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS11750	COG0204	Acyl-transferase
DEH18_RS11755	COG0584	glycerophosphoryl diester phosphodiesterase
DEH18_RS11785	COG2011	ABC-type metal ion transport system permease component
DEH18_RS11800	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DEH18_RS11805	COG1648	precorrin-2 dehydrogenase activity
DEH18_RS11805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DEH18_RS11860	COG0512	Glutamine amidotransferase of anthranilate synthase
DEH18_RS11860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DEH18_RS11920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DEH18_RS11945	COG1560	Kdo2-lipid A biosynthetic process
DEH18_RS11950	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS11960	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DEH18_RS11965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DEH18_RS11970	COG0217	transcriptional regulatory protein
DEH18_RS11975	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DEH18_RS11980	COG0632	four-way junction helicase activity
DEH18_RS11985	COG2255	four-way junction helicase activity
DEH18_RS11995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DEH18_RS12000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DEH18_RS12005	COG2186	Transcriptional regulator
DEH18_RS12010	COG0247	lactate metabolic process
DEH18_RS12020	COG1556	Lactate utilization protein
DEH18_RS12025	COG2814	Major facilitator Superfamily
DEH18_RS12030	COG3254	rhamnose metabolic process
DEH18_RS12040	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS12045	COG4948	Mandelate Racemase Muconate Lactonizing
DEH18_RS12050	COG0179	Fumarylacetoacetate (FAA) hydrolase
DEH18_RS12055	COG3618	amidohydrolase
DEH18_RS12060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DEH18_RS12065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DEH18_RS12070	COG1196	nuclear chromosome segregation
DEH18_RS12075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DEH18_RS12085	COG0124	histidyl-tRNA synthetase
DEH18_RS12105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DEH18_RS12125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DEH18_RS12130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DEH18_RS12140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DEH18_RS12145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DEH18_RS12150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DEH18_RS12155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DEH18_RS12165	COG0006	proline dipeptidase activity
DEH18_RS12170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DEH18_RS12175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DEH18_RS12185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DEH18_RS12190	COG0540	Belongs to the ATCase OTCase family
DEH18_RS12195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DEH18_RS12205	COG0505	Belongs to the CarA family
DEH18_RS12210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DEH18_RS12215	COG0167	dihydroorotate dehydrogenase activity
DEH18_RS12220	COG0284	orotidine-5'-phosphate decarboxylase activity
DEH18_RS12230	COG0194	GDP metabolic process
DEH18_RS12235	COG1758	RNA polymerase activity
DEH18_RS12245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DEH18_RS12275	COG0477	Major facilitator Superfamily
DEH18_RS12300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DEH18_RS12310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DEH18_RS12315	COG2390	Transcriptional regulator
DEH18_RS12325	COG0475	glutathione-regulated potassium exporter activity
DEH18_RS12330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS12335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS12345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS12365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS12405	COG0446	pyridine nucleotide-disulphide oxidoreductase
DEH18_RS12405	COG1902	pentaerythritol trinitrate reductase activity
DEH18_RS12410	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DEH18_RS12430	COG4221	oxidoreductase activity
DEH18_RS12465	COG2233	PERMEase
DEH18_RS12470	COG0738	Major facilitator superfamily
DEH18_RS12485	COG3201	nicotinamide mononucleotide transporter
DEH18_RS12490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DEH18_RS12490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DEH18_RS12495	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DEH18_RS12500	COG0140	phosphoribosyl-ATP diphosphatase activity
DEH18_RS12505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DEH18_RS12615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DEH18_RS12620	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS12625	COG0604	alcohol dehydrogenase
DEH18_RS12640	COG4585	Histidine kinase
DEH18_RS12645	COG2197	response regulator
DEH18_RS12675	COG2249	NAD(P)H dehydrogenase (quinone) activity
DEH18_RS12685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DEH18_RS12690	COG1518	maintenance of DNA repeat elements
DEH18_RS12705	COG1857	crispr-associated protein
DEH18_RS12755	COG2197	response regulator
DEH18_RS12770	COG0640	Transcriptional regulator
DEH18_RS12790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DEH18_RS12795	COG0066	3-isopropylmalate dehydratase activity
DEH18_RS12800	COG0583	DNA-binding transcription factor activity
DEH18_RS12815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DEH18_RS12835	COG0656	L-ascorbic acid biosynthetic process
DEH18_RS12840	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS12850	COG3104	oligopeptide transport
DEH18_RS12855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS12905	COG1309	transcriptional regulator
DEH18_RS12915	COG0640	Transcriptional regulator
DEH18_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS12950	COG2814	Major facilitator Superfamily
DEH18_RS12960	COG2186	Transcriptional regulator
DEH18_RS12970	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS12980	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS12985	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS12995	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS13000	COG1024	Enoyl-CoA hydratase
DEH18_RS13005	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS13010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DEH18_RS13065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DEH18_RS13075	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DEH18_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS13090	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS13110	COG0477	Major facilitator Superfamily
DEH18_RS13115	COG2124	cytochrome p450
DEH18_RS13160	COG1902	pentaerythritol trinitrate reductase activity
DEH18_RS13160	COG0446	pyridine nucleotide-disulphide oxidoreductase
DEH18_RS13180	COG3629	intracellular signal transduction
DEH18_RS13180	COG3903	Transcriptional regulator
DEH18_RS13185	COG0604	alcohol dehydrogenase
DEH18_RS13190	COG1733	regulation of RNA biosynthetic process
DEH18_RS13260	COG1063	alcohol dehydrogenase
DEH18_RS13285	COG1140	nitrate reductase beta subunit
DEH18_RS13305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DEH18_RS13310	COG1993	acr, cog1993
DEH18_RS13315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DEH18_RS13350	COG0702	epimerase
DEH18_RS13450	COG1181	Belongs to the D-alanine--D-alanine ligase family
DEH18_RS13455	COG2233	PERMEase
DEH18_RS13465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS13470	COG0431	NADPH-dependent FMN reductase
DEH18_RS13480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DEH18_RS13500	COG0730	response to heat
DEH18_RS13510	COG1309	transcriptional regulator
DEH18_RS13555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DEH18_RS13560	COG2192	nodulation
DEH18_RS13585	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS13595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DEH18_RS13595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DEH18_RS13600	COG0859	PFAM glycosyl transferase family 9
DEH18_RS13635	COG4221	oxidoreductase activity
DEH18_RS13655	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS13660	COG0515	serine threonine protein kinase
DEH18_RS13665	COG2070	2-Nitropropane dioxygenase
DEH18_RS13690	COG1024	Enoyl-CoA hydratase
DEH18_RS13770	COG4336	lyase activity
DEH18_RS13805	COG2018	Roadblock/LC7 domain
DEH18_RS13820	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DEH18_RS13835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DEH18_RS13840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DEH18_RS13870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DEH18_RS13910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DEH18_RS13920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DEH18_RS13920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DEH18_RS13950	COG1295	ribonuclease BN
DEH18_RS13955	COG1695	Transcriptional regulator
DEH18_RS13970	COG3386	PFAM SMP-30 Gluconolaconase
DEH18_RS13975	COG4214	carbohydrate transport
DEH18_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS14045	COG0583	DNA-binding transcription factor activity
DEH18_RS14050	COG2356	endonuclease I
DEH18_RS14085	COG0464	growth
DEH18_RS14170	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS14175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DEH18_RS14235	COG1968	undecaprenyl-diphosphatase activity
DEH18_RS14245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DEH18_RS14275	COG0110	maltose O-acetyltransferase activity
DEH18_RS14295	COG1832	CoA-binding protein
DEH18_RS14300	COG1739	Uncharacterized protein family UPF0029
DEH18_RS14305	COG0420	3'-5' exonuclease activity
DEH18_RS14310	COG0419	ATPase involved in DNA repair
DEH18_RS14340	COG4762	Protein conserved in bacteria
DEH18_RS14360	COG0596	Alpha beta hydrolase
DEH18_RS14365	COG1595	DNA-templated transcription, initiation
DEH18_RS14370	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS14375	COG2188	Transcriptional regulator
DEH18_RS14390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DEH18_RS14420	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DEH18_RS14425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DEH18_RS14430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DEH18_RS14435	COG0156	8-amino-7-oxononanoate synthase activity
DEH18_RS14440	COG2172	sigma factor antagonist activity
DEH18_RS14450	COG0740	serine-type endopeptidase activity
DEH18_RS14460	COG4935	Belongs to the peptidase S8 family
DEH18_RS14460	COG2234	aminopeptidase activity
DEH18_RS14465	COG0831	urea catabolic process
DEH18_RS14470	COG0832	Belongs to the urease beta subunit family
DEH18_RS14475	COG0804	urea catabolic process
DEH18_RS14485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DEH18_RS14490	COG0829	nickel cation binding
DEH18_RS14495	COG0596	Alpha beta hydrolase
DEH18_RS14505	COG0204	Acyl-transferase
DEH18_RS14530	COG0693	protein deglycase activity
DEH18_RS14540	COG3442	glutamine amidotransferase
DEH18_RS14550	COG0242	peptide deformylase activity
DEH18_RS14560	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS14565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DEH18_RS14575	COG0596	Alpha beta hydrolase
DEH18_RS14600	COG4585	Histidine kinase
DEH18_RS14605	COG2197	response regulator
DEH18_RS14630	COG1660	Displays ATPase and GTPase activities
DEH18_RS14640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS14660	COG0667	Aldo Keto reductase
DEH18_RS14675	COG4221	oxidoreductase activity
DEH18_RS14695	COG1940	carbohydrate kinase activity
DEH18_RS14705	COG4585	Histidine kinase
DEH18_RS14710	COG2197	response regulator
DEH18_RS14730	COG1349	DNA-binding transcription factor activity
DEH18_RS14750	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DEH18_RS14760	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS14785	COG0463	Glycosyl transferase, family 2
DEH18_RS14790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DEH18_RS14800	COG4585	Histidine kinase
DEH18_RS14805	COG1051	belongs to the nudix hydrolase family
DEH18_RS14830	COG1216	Glycosyl transferase, family 2
DEH18_RS14850	COG1461	Dihydroxyacetone kinase
DEH18_RS14855	COG2376	Dihydroxyacetone kinase
DEH18_RS14890	COG4221	oxidoreductase activity
DEH18_RS14935	COG2175	clavaminate synthase activity
DEH18_RS14940	COG3251	PFAM MbtH domain protein
DEH18_RS14945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DEH18_RS14970	COG0300	oxidoreductase activity
DEH18_RS14995	COG1136	(ABC) transporter
DEH18_RS14995	COG0577	efflux transmembrane transporter activity
DEH18_RS15030	COG4585	Histidine kinase
DEH18_RS15040	COG0583	DNA-binding transcription factor activity
DEH18_RS15045	COG0483	inositol monophosphate 1-phosphatase activity
DEH18_RS15065	COG1733	regulation of RNA biosynthetic process
DEH18_RS15105	COG1309	transcriptional regulator
DEH18_RS15110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS15120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DEH18_RS15130	COG4638	Rieske (2fe-2S)
DEH18_RS15145	COG2318	DinB family
DEH18_RS15160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DEH18_RS15175	COG1234	tRNA 3'-trailer cleavage
DEH18_RS15190	COG0659	secondary active sulfate transmembrane transporter activity
DEH18_RS15195	COG0789	Transcriptional regulator
DEH18_RS15225	COG2171	N-acyltransferase activity
DEH18_RS15230	COG0667	Aldo Keto reductase
DEH18_RS15245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DEH18_RS15255	COG2376	Dihydroxyacetone kinase
DEH18_RS15260	COG1461	Dihydroxyacetone kinase
DEH18_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS15270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DEH18_RS15280	COG1136	(ABC) transporter
DEH18_RS15280	COG0577	efflux transmembrane transporter activity
DEH18_RS15285	COG0577	efflux transmembrane transporter activity
DEH18_RS15285	COG1136	(ABC) transporter
DEH18_RS15290	COG2197	response regulator
DEH18_RS15295	COG4585	Histidine kinase
DEH18_RS15315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DEH18_RS15340	COG0346	lactoylglutathione lyase activity
DEH18_RS15345	COG0640	Transcriptional regulator
DEH18_RS15390	COG0443	Heat shock 70 kDa protein
DEH18_RS15425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DEH18_RS15430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DEH18_RS15430	COG2080	2 iron, 2 sulfur cluster binding
DEH18_RS15450	COG0477	Major facilitator Superfamily
DEH18_RS15455	COG2409	Drug exporters of the RND superfamily
DEH18_RS15540	COG1181	Belongs to the D-alanine--D-alanine ligase family
DEH18_RS15545	COG0583	DNA-binding transcription factor activity
DEH18_RS15575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DEH18_RS15580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DEH18_RS15580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DEH18_RS15585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DEH18_RS15590	COG1937	Protein conserved in bacteria
DEH18_RS15595	COG0730	response to heat
DEH18_RS15610	COG1309	transcriptional regulator
DEH18_RS15625	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS15675	COG1228	amidohydrolase
DEH18_RS15685	COG0463	Glycosyl transferase, family 2
DEH18_RS15700	COG2270	Major facilitator Superfamily
DEH18_RS15715	COG0667	Aldo Keto reductase
DEH18_RS15720	COG0583	DNA-binding transcription factor activity
DEH18_RS15730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DEH18_RS15775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DEH18_RS15780	COG0583	DNA-binding transcription factor activity
DEH18_RS15805	COG5640	endopeptidase activity
DEH18_RS15820	COG0702	epimerase
DEH18_RS15835	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS15840	COG0824	Thioesterase
DEH18_RS15840	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS15850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DEH18_RS15870	COG2124	cytochrome p450
DEH18_RS15970	COG2197	response regulator
DEH18_RS15995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DEH18_RS16005	COG2890	protein-(glutamine-N5) methyltransferase activity
DEH18_RS16110	COG2072	flavoprotein involved in K transport
DEH18_RS16130	COG1027	Aspartate ammonia-lyase
DEH18_RS16140	COG0583	DNA-binding transcription factor activity
DEH18_RS16150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DEH18_RS16155	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS16160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS16170	COG0531	amino acid
DEH18_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS16190	COG0583	DNA-binding transcription factor activity
DEH18_RS16210	COG1175	transmembrane transport
DEH18_RS16215	COG0395	ABC-type sugar transport system, permease component
DEH18_RS16220	COG1609	Transcriptional regulator
DEH18_RS16225	COG1874	Beta-galactosidase
DEH18_RS16260	COG0477	Major facilitator Superfamily
DEH18_RS16270	COG0596	Alpha beta hydrolase
DEH18_RS16290	COG1309	transcriptional regulator
DEH18_RS16300	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS16320	COG0542	response to heat
DEH18_RS16365	COG0667	Aldo Keto reductase
DEH18_RS16375	COG2197	response regulator
DEH18_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS16395	COG1309	transcriptional regulator
DEH18_RS16415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DEH18_RS16430	COG4948	Mandelate Racemase Muconate Lactonizing
DEH18_RS16440	COG0531	amino acid
DEH18_RS16455	COG2814	Major facilitator Superfamily
DEH18_RS16460	COG1802	Transcriptional regulator
DEH18_RS16490	COG2814	Major facilitator Superfamily
DEH18_RS16505	COG1309	transcriptional regulator
DEH18_RS16525	COG0583	DNA-binding transcription factor activity
DEH18_RS16530	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS16535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DEH18_RS16575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS16575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DEH18_RS16590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DEH18_RS16615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS16640	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS16650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DEH18_RS16700	COG3903	Transcriptional regulator
DEH18_RS16700	COG3629	intracellular signal transduction
DEH18_RS16715	COG2197	response regulator
DEH18_RS16725	COG1619	proteins homologs of microcin C7 resistance protein MccF
DEH18_RS16770	COG1131	(ABC) transporter
DEH18_RS16775	COG1051	belongs to the nudix hydrolase family
DEH18_RS16810	COG0583	DNA-binding transcription factor activity
DEH18_RS16830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS16855	COG1309	transcriptional regulator
DEH18_RS16880	COG1597	lipid kinase activity
DEH18_RS16895	COG4638	Rieske (2fe-2S)
DEH18_RS16900	COG0446	pyridine nucleotide-disulphide oxidoreductase
DEH18_RS16900	COG1902	pentaerythritol trinitrate reductase activity
DEH18_RS16920	COG0179	Fumarylacetoacetate (FAA) hydrolase
DEH18_RS16935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS16935	COG2022	thiamine diphosphate biosynthetic process
DEH18_RS16940	COG1309	transcriptional regulator
DEH18_RS16965	COG1846	Transcriptional regulator
DEH18_RS16970	COG0464	growth
DEH18_RS17020	COG1674	ftsk spoiiie
DEH18_RS17030	COG0596	Alpha beta hydrolase
DEH18_RS17045	COG0583	DNA-binding transcription factor activity
DEH18_RS17050	COG0477	Major facilitator Superfamily
DEH18_RS17085	COG1309	transcriptional regulator
DEH18_RS17090	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17095	COG2364	Membrane
DEH18_RS17115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DEH18_RS17145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DEH18_RS17150	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS17170	COG0667	Aldo Keto reductase
DEH18_RS17185	COG0179	Fumarylacetoacetate (FAA) hydrolase
DEH18_RS17200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS17220	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17225	COG1309	transcriptional regulator
DEH18_RS17235	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17255	COG0300	oxidoreductase activity
DEH18_RS17260	COG1309	transcriptional regulator
DEH18_RS17265	COG0300	oxidoreductase activity
DEH18_RS17280	COG0110	maltose O-acetyltransferase activity
DEH18_RS17290	COG1122	ATPase activity
DEH18_RS17295	COG3845	ABC transporter
DEH18_RS17340	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17345	COG0667	Aldo Keto reductase
DEH18_RS17355	COG1309	transcriptional regulator
DEH18_RS17405	COG0596	Alpha beta hydrolase
DEH18_RS17465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DEH18_RS17480	COG0673	inositol 2-dehydrogenase activity
DEH18_RS17485	COG3959	Transketolase, thiamine diphosphate binding domain
DEH18_RS17490	COG3958	Transketolase
DEH18_RS17510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS17520	COG4106	trans-aconitate 2-methyltransferase activity
DEH18_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DEH18_RS17545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DEH18_RS17550	COG2226	methyltransferase
DEH18_RS17555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DEH18_RS17565	COG2197	response regulator
DEH18_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17650	COG0165	Argininosuccinate lyase
DEH18_RS17660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DEH18_RS17730	COG3424	synthase
DEH18_RS17735	COG1024	Enoyl-CoA hydratase
DEH18_RS17740	COG1024	Enoyl-CoA hydratase
DEH18_RS17750	COG1834	amidinotransferase
DEH18_RS17760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DEH18_RS17770	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DEH18_RS17825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DEH18_RS17855	COG4977	sequence-specific DNA binding
DEH18_RS17890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DEH18_RS17915	COG0300	oxidoreductase activity
DEH18_RS17915	COG3321	synthase
DEH18_RS17915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS17915	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS17935	COG4221	oxidoreductase activity
DEH18_RS17935	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS17935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS17935	COG3321	synthase
DEH18_RS17950	COG4221	oxidoreductase activity
DEH18_RS17950	COG3321	synthase
DEH18_RS17950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DEH18_RS17950	COG0300	oxidoreductase activity
DEH18_RS17980	COG1309	transcriptional regulator
DEH18_RS17985	COG0328	RNA-DNA hybrid ribonuclease activity
DEH18_RS18000	COG0395	ABC-type sugar transport system, permease component
DEH18_RS18005	COG1175	transmembrane transport
DEH18_RS18010	COG2182	Extracellular solute-binding protein
DEH18_RS18030	COG0154	amidase activity
DEH18_RS18055	COG2318	DinB family
DEH18_RS18110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS18115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DEH18_RS18120	COG1609	Transcriptional regulator
DEH18_RS18130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DEH18_RS18145	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DEH18_RS18170	COG0367	asparagine synthase
DEH18_RS18195	COG0584	glycerophosphoryl diester phosphodiesterase
DEH18_RS18235	COG1309	transcriptional regulator
DEH18_RS18250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DEH18_RS18265	COG2706	6-phosphogluconolactonase activity
DEH18_RS18270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DEH18_RS18275	COG2318	DinB family
DEH18_RS18280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DEH18_RS18295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DEH18_RS18305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DEH18_RS18315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DEH18_RS18325	COG2233	PERMEase
DEH18_RS18330	COG0402	S-adenosylhomocysteine deaminase activity
DEH18_RS18335	COG0523	cobalamin synthesis protein
DEH18_RS18340	COG1937	Protein conserved in bacteria
DEH18_RS18345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DEH18_RS18350	COG3119	arylsulfatase activity
DEH18_RS18355	COG1940	carbohydrate kinase activity
DEH18_RS18370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DEH18_RS18380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DEH18_RS18430	COG2814	Major facilitator Superfamily
DEH18_RS18440	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DEH18_RS18440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS18455	COG1021	2,3-dihydroxybenzoate-AMP ligase
DEH18_RS18460	COG2124	cytochrome p450
DEH18_RS18470	COG0367	asparagine synthase
DEH18_RS18475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS18495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS18495	COG3433	isochorismatase activity
DEH18_RS18495	COG2226	methyltransferase
DEH18_RS18525	COG1122	ATPase activity
DEH18_RS18550	COG1131	(ABC) transporter
DEH18_RS18560	COG1595	DNA-templated transcription, initiation
DEH18_RS18590	COG1959	2 iron, 2 sulfur cluster binding
DEH18_RS18600	COG2072	flavoprotein involved in K transport
DEH18_RS18615	COG0583	DNA-binding transcription factor activity
DEH18_RS18635	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS18645	COG1309	transcriptional regulator
DEH18_RS18655	COG1476	TRANSCRIPTIONal
DEH18_RS18690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DEH18_RS18700	COG1132	(ABC) transporter
DEH18_RS18710	COG1216	Glycosyl transferase, family 2
DEH18_RS18745	COG2197	response regulator
DEH18_RS18765	COG1902	pentaerythritol trinitrate reductase activity
DEH18_RS18765	COG0446	pyridine nucleotide-disulphide oxidoreductase
DEH18_RS18845	COG1113	amino acid transport
DEH18_RS18850	COG2362	D-Aminopeptidase
DEH18_RS18855	COG0019	diaminopimelate decarboxylase activity
DEH18_RS18860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DEH18_RS18860	COG2508	Transcriptional regulator
DEH18_RS18860	COG2508	Transcriptional regulator
DEH18_RS18860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DEH18_RS18870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DEH18_RS18875	COG1414	Transcriptional regulator
DEH18_RS18885	COG2267	carboxylic ester hydrolase activity
DEH18_RS18905	COG1063	alcohol dehydrogenase
DEH18_RS18910	COG1414	Transcriptional regulator
DEH18_RS18930	COG0477	Major facilitator Superfamily
DEH18_RS18930	COG2814	Major facilitator Superfamily
DEH18_RS18955	COG2124	cytochrome p450
DEH18_RS18960	COG2197	response regulator
DEH18_RS18975	COG1408	metallophosphoesterase
DEH18_RS18980	COG1846	Transcriptional regulator
DEH18_RS18995	COG0432	Pfam Uncharacterised protein family UPF0047
DEH18_RS19000	COG2072	flavoprotein involved in K transport
DEH18_RS19005	COG1609	Transcriptional regulator
DEH18_RS19025	COG1129	ABC transporter
DEH18_RS19035	COG1070	Carbohydrate kinase
DEH18_RS19050	COG1119	ATPase activity
DEH18_RS19065	COG3876	Protein conserved in bacteria
DEH18_RS19075	COG1132	(ABC) transporter
DEH18_RS19085	COG0277	FAD linked oxidase domain protein
DEH18_RS19105	COG1132	(ABC) transporter
DEH18_RS19110	COG1132	(ABC) transporter
DEH18_RS19125	COG1946	Acyl-CoA thioesterase
DEH18_RS19135	COG2018	Roadblock/LC7 domain
DEH18_RS19160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DEH18_RS19220	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS19225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS19230	COG2197	response regulator
DEH18_RS19250	COG1215	transferase activity, transferring glycosyl groups
DEH18_RS19255	COG1252	NADH dehydrogenase
DEH18_RS19265	COG0477	Major facilitator Superfamily
DEH18_RS19275	COG1278	Cold shock
DEH18_RS19290	COG1349	DNA-binding transcription factor activity
DEH18_RS19310	COG1063	alcohol dehydrogenase
DEH18_RS19330	COG0301	tRNA thio-modification
DEH18_RS19340	COG2318	DinB family
DEH18_RS19350	COG1024	Enoyl-CoA hydratase
DEH18_RS19370	COG1129	ABC transporter
DEH18_RS19395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS19400	COG1006	Multisubunit Na H antiporter MnhC subunit
DEH18_RS19425	COG1982	Orn Lys Arg decarboxylase major
DEH18_RS19430	COG1793	dna ligase
DEH18_RS19460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DEH18_RS19460	COG1017	nitric oxide dioxygenase activity
DEH18_RS19465	COG2267	carboxylic ester hydrolase activity
DEH18_RS19490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DEH18_RS19525	COG0435	Glutathione S-transferase
DEH18_RS19570	COG0488	(ABC) transporter
DEH18_RS19585	COG0726	polysaccharide deacetylase
DEH18_RS19600	COG0477	Major facilitator Superfamily
DEH18_RS19610	COG1349	DNA-binding transcription factor activity
DEH18_RS19615	COG0588	phosphoglycerate mutase activity
DEH18_RS19625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DEH18_RS19630	COG1063	alcohol dehydrogenase
DEH18_RS19645	COG0395	ABC-type sugar transport system, permease component
DEH18_RS19650	COG1175	transmembrane transport
DEH18_RS19685	COG0640	Transcriptional regulator
DEH18_RS19690	COG2072	flavoprotein involved in K transport
DEH18_RS19695	COG0798	PFAM Bile acid sodium symporter
DEH18_RS19710	COG0110	maltose O-acetyltransferase activity
DEH18_RS19715	COG0488	(ABC) transporter
DEH18_RS19720	COG2814	Major facilitator Superfamily
DEH18_RS19725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DEH18_RS19730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DEH18_RS19735	COG0277	FAD linked oxidase domain protein
DEH18_RS19775	COG2936	dipeptidyl-peptidase activity
DEH18_RS19780	COG1288	antiporter activity
DEH18_RS19785	COG0346	lactoylglutathione lyase activity
DEH18_RS19810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS19820	COG0367	asparagine synthase
DEH18_RS19825	COG0154	amidase activity
DEH18_RS19835	COG0477	Major facilitator Superfamily
DEH18_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS19840	COG3347	Dehydrogenase
DEH18_RS19860	COG0789	Transcriptional regulator
DEH18_RS19905	COG2146	nitrite reductase [NAD(P)H] activity
DEH18_RS19910	COG1414	Transcriptional regulator
DEH18_RS19925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS19930	COG4638	Rieske (2fe-2S)
DEH18_RS19985	COG2186	Transcriptional regulator
DEH18_RS19990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS19995	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS20010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DEH18_RS20045	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS20055	COG0254	rRNA binding
DEH18_RS20090	COG2353	YceI-like domain
DEH18_RS20105	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS20110	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS20115	COG0583	DNA-binding transcription factor activity
DEH18_RS20145	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS20150	COG2949	membrane
DEH18_RS20155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DEH18_RS20160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DEH18_RS20175	COG1793	dna ligase
DEH18_RS20180	COG1793	dna ligase
DEH18_RS20195	COG2197	response regulator
DEH18_RS20215	COG0515	serine threonine protein kinase
DEH18_RS20230	COG1953	Uracil, thiamine, allantoin
DEH18_RS20240	COG0537	adenosine 5'-monophosphoramidase activity
DEH18_RS20245	COG0656	L-ascorbic acid biosynthetic process
DEH18_RS20250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DEH18_RS20255	COG0589	response to stress
DEH18_RS20260	COG1063	alcohol dehydrogenase
DEH18_RS20265	COG0542	response to heat
DEH18_RS20280	COG3973	AAA domain
DEH18_RS20330	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS20335	COG1316	TRANSCRIPTIONal
DEH18_RS20340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS20340	COG0723	plastoquinol--plastocyanin reductase activity
DEH18_RS20355	COG1124	(ABC) transporter
DEH18_RS20360	COG0444	Belongs to the ABC transporter superfamily
DEH18_RS20365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DEH18_RS20370	COG0601	transmembrane transport
DEH18_RS20400	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS20420	COG2018	Roadblock/LC7 domain
DEH18_RS20445	COG0693	protein deglycase activity
DEH18_RS20475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DEH18_RS20490	COG1657	PFAM Prenyltransferase squalene oxidase
DEH18_RS20500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS20500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DEH18_RS20510	COG1562	ergosterol biosynthetic process
DEH18_RS20520	COG2409	Drug exporters of the RND superfamily
DEH18_RS20525	COG1388	LysM domain
DEH18_RS20525	COG1134	teichoic acid transport
DEH18_RS20545	COG1454	alcohol dehydrogenase
DEH18_RS20565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DEH18_RS20575	COG1024	Enoyl-CoA hydratase
DEH18_RS20585	COG2183	response to ionizing radiation
DEH18_RS20590	COG0778	Nitroreductase
DEH18_RS20595	COG0488	(ABC) transporter
DEH18_RS20620	COG1113	amino acid transport
DEH18_RS20635	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS20635	COG1024	Enoyl-CoA hydratase
DEH18_RS20640	COG0183	Belongs to the thiolase family
DEH18_RS20645	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS20650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DEH18_RS20655	COG0477	Major facilitator Superfamily
DEH18_RS20670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DEH18_RS20675	COG0191	fructose-bisphosphate aldolase activity
DEH18_RS20680	COG1349	DNA-binding transcription factor activity
DEH18_RS20695	COG3409	Peptidoglycan-binding domain 1 protein
DEH18_RS20695	COG3757	hydrolase, family 25
DEH18_RS20710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DEH18_RS20715	COG3268	Saccharopine dehydrogenase
DEH18_RS20720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS20725	COG0446	pyridine nucleotide-disulphide oxidoreductase
DEH18_RS20725	COG1902	pentaerythritol trinitrate reductase activity
DEH18_RS20740	COG0318	PFAM AMP-dependent synthetase and ligase
DEH18_RS20750	COG3012	SEC-C Motif Domain Protein
DEH18_RS20775	COG5564	TIM-barrel signal transduction protein
DEH18_RS20785	COG1620	l-lactate permease
DEH18_RS20795	COG2226	methyltransferase
DEH18_RS20820	COG2186	Transcriptional regulator
DEH18_RS20825	COG3265	gluconokinase activity
DEH18_RS20840	COG0583	DNA-binding transcription factor activity
DEH18_RS20865	COG1917	Cupin 2, conserved barrel domain protein
DEH18_RS20880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DEH18_RS20890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DEH18_RS20900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS20905	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS20930	COG1515	deoxyribonuclease V activity
DEH18_RS20935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DEH18_RS20940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DEH18_RS20995	COG1653	transport
DEH18_RS21005	COG2365	Tyrosine phosphatase family
DEH18_RS21010	COG2755	lipolytic protein G-D-S-L family
DEH18_RS21045	COG2746	aminoglycoside 3-N-acetyltransferase activity
DEH18_RS21050	COG0254	rRNA binding
DEH18_RS21055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DEH18_RS21060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DEH18_RS21085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DEH18_RS21090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS21105	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS21110	COG2610	gluconate transmembrane transporter activity
DEH18_RS21130	COG3387	PFAM Glycoside hydrolase 15-related
DEH18_RS21135	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS21140	COG0028	Belongs to the TPP enzyme family
DEH18_RS21145	COG4948	Mandelate Racemase Muconate Lactonizing
DEH18_RS21150	COG0277	FAD linked oxidase domain protein
DEH18_RS21150	COG0247	lactate metabolic process
DEH18_RS21165	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS21175	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS21185	COG4948	Mandelate Racemase Muconate Lactonizing
DEH18_RS21200	COG1653	transport
DEH18_RS21210	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS21215	COG2186	Transcriptional regulator
DEH18_RS21230	COG0505	Belongs to the CarA family
DEH18_RS21235	COG2186	Transcriptional regulator
DEH18_RS21240	COG1397	ADP-ribosylglycohydrolase
DEH18_RS21260	COG0437	4 iron, 4 sulfur cluster binding
DEH18_RS21270	COG0243	molybdopterin cofactor binding
DEH18_RS21270	COG3383	formate dehydrogenase (NAD+) activity
DEH18_RS21275	COG3383	formate dehydrogenase (NAD+) activity
DEH18_RS21275	COG0243	molybdopterin cofactor binding
DEH18_RS21280	COG0709	Synthesizes selenophosphate from selenide and ATP
DEH18_RS21300	COG1921	L-seryl-tRNASec selenium transferase activity
DEH18_RS21310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DEH18_RS21330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS21360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DEH18_RS21365	COG1063	alcohol dehydrogenase
DEH18_RS21415	COG3964	amidohydrolase
DEH18_RS21420	COG1414	Transcriptional regulator
DEH18_RS21515	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS21530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DEH18_RS21545	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS21555	COG1024	Enoyl-CoA hydratase
DEH18_RS21575	COG0183	Belongs to the thiolase family
DEH18_RS21580	COG1309	transcriptional regulator
DEH18_RS21585	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS21590	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS21595	COG1024	Enoyl-CoA hydratase
DEH18_RS21600	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS21605	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS21610	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS21625	COG3209	COG3209 Rhs family protein
DEH18_RS21650	COG1053	succinate dehydrogenase
DEH18_RS21665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DEH18_RS21675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS21690	COG2365	Tyrosine phosphatase family
DEH18_RS21695	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS21730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DEH18_RS21735	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DEH18_RS21745	COG2267	carboxylic ester hydrolase activity
DEH18_RS21780	COG1674	ftsk spoiiie
DEH18_RS21860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DEH18_RS21865	COG0477	Major facilitator Superfamily
DEH18_RS21875	COG1902	pentaerythritol trinitrate reductase activity
DEH18_RS21885	COG4325	translation initiation factor activity
DEH18_RS21950	COG0673	inositol 2-dehydrogenase activity
DEH18_RS21955	COG1879	ABC-type sugar transport system periplasmic component
DEH18_RS21960	COG1172	Belongs to the binding-protein-dependent transport system permease family
DEH18_RS21965	COG1129	ABC transporter
DEH18_RS21970	COG1940	carbohydrate kinase activity
DEH18_RS21975	COG1595	DNA-templated transcription, initiation
DEH18_RS21980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DEH18_RS21995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DEH18_RS22005	COG0713	ATP synthesis coupled electron transport
DEH18_RS22010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DEH18_RS22020	COG1007	ATP synthesis coupled electron transport
DEH18_RS22035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DEH18_RS22050	COG0656	L-ascorbic acid biosynthetic process
DEH18_RS22055	COG2154	pterin-4-alpha-carbinolamine dehydratase
DEH18_RS22075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DEH18_RS22110	COG0517	IMP dehydrogenase activity
DEH18_RS22115	COG4106	trans-aconitate 2-methyltransferase activity
DEH18_RS22140	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DEH18_RS22155	COG1506	peptidase
DEH18_RS22155	COG4946	Tricorn protease homolog
DEH18_RS22155	COG0823	Involved in the tonB-independent uptake of proteins
DEH18_RS22160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS22165	COG2362	D-Aminopeptidase
DEH18_RS22225	COG2301	Belongs to the HpcH HpaI aldolase family
DEH18_RS22235	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS22240	COG0688	phosphatidylethanolamine metabolic process
DEH18_RS22250	COG1929	Belongs to the glycerate kinase type-1 family
DEH18_RS22255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DEH18_RS22265	COG0483	inositol monophosphate 1-phosphatase activity
DEH18_RS22270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DEH18_RS22280	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS22285	COG0095	Lipoate-protein ligase
DEH18_RS22310	COG0644	oxidoreductase
DEH18_RS22315	COG0242	peptide deformylase activity
DEH18_RS22325	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS22335	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS22340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS22380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DEH18_RS22390	COG0697	spore germination
DEH18_RS22395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DEH18_RS22410	COG4607	ABC-type enterochelin transport system periplasmic component
DEH18_RS22415	COG2382	esterase
DEH18_RS22425	COG1132	(ABC) transporter
DEH18_RS22450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS22455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DEH18_RS22490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS22495	COG3433	isochorismatase activity
DEH18_RS22495	COG1535	isochorismatase
DEH18_RS22500	COG1021	2,3-dihydroxybenzoate-AMP ligase
DEH18_RS22505	COG1169	isochorismate synthase
DEH18_RS22510	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS22520	COG1309	transcriptional regulator
DEH18_RS22530	COG2366	antibiotic biosynthetic process
DEH18_RS22535	COG1335	isochorismatase
DEH18_RS22585	COG0583	DNA-binding transcription factor activity
DEH18_RS22590	COG2814	Major facilitator Superfamily
DEH18_RS22600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DEH18_RS22605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DEH18_RS22625	COG0477	Major facilitator Superfamily
DEH18_RS22630	COG1335	isochorismatase
DEH18_RS22640	COG0405	Gamma-glutamyltransferase
DEH18_RS22650	COG0765	amino acid transport
DEH18_RS22655	COG0765	amino acid transport
DEH18_RS22660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DEH18_RS22665	COG1126	abc transporter atp-binding protein
DEH18_RS22690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DEH18_RS22695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DEH18_RS22705	COG1940	carbohydrate kinase activity
DEH18_RS22745	COG0800	Aldolase
DEH18_RS22760	COG4266	Belongs to the allantoicase family
DEH18_RS22765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DEH18_RS22770	COG1414	Transcriptional regulator
DEH18_RS22785	COG0746	molybdenum cofactor guanylyltransferase activity
DEH18_RS22830	COG3340	Belongs to the peptidase S51 family
DEH18_RS22835	COG2226	methyltransferase
DEH18_RS22845	COG2233	PERMEase
DEH18_RS22860	COG2351	hydroxyisourate hydrolase activity
DEH18_RS22880	COG0535	radical SAM domain protein
DEH18_RS22915	COG3622	Belongs to the hyi family
DEH18_RS22920	COG2084	Dehydrogenase
DEH18_RS22925	COG3960	tartronate-semialdehyde synthase activity
DEH18_RS22930	COG0753	catalase activity
DEH18_RS22940	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS22955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DEH18_RS22970	COG2252	PERMEase
DEH18_RS22990	COG3835	regulator
DEH18_RS23000	COG2197	response regulator
DEH18_RS23005	COG4585	Histidine kinase
DEH18_RS23025	COG1802	Transcriptional regulator
DEH18_RS23060	COG1162	GTPase activity
DEH18_RS23065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DEH18_RS23070	COG0590	tRNA wobble adenosine to inosine editing
DEH18_RS23080	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS23100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DEH18_RS23105	COG0494	nUDIX hydrolase
DEH18_RS23110	COG3119	arylsulfatase activity
DEH18_RS23120	COG2124	cytochrome p450
DEH18_RS23125	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DEH18_RS23140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DEH18_RS23145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DEH18_RS23180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DEH18_RS23190	COG0175	sulfate reduction
DEH18_RS23215	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DEH18_RS23220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DEH18_RS23230	COG0745	RESPONSE REGULATOR receiver
DEH18_RS23275	COG0583	DNA-binding transcription factor activity
DEH18_RS23280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DEH18_RS23295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DEH18_RS23300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DEH18_RS23360	COG0446	pyridine nucleotide-disulphide oxidoreductase
DEH18_RS23365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DEH18_RS23375	COG2197	response regulator
DEH18_RS23385	COG0183	Belongs to the thiolase family
DEH18_RS23390	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS23390	COG1024	Enoyl-CoA hydratase
DEH18_RS23400	COG1473	amidohydrolase
DEH18_RS23405	COG2814	Major facilitator Superfamily
DEH18_RS23425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DEH18_RS23430	COG4214	carbohydrate transport
DEH18_RS23440	COG4213	ABC transporter substrate-binding protein
DEH18_RS23445	COG1940	carbohydrate kinase activity
DEH18_RS23485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DEH18_RS23490	COG1042	CoA-binding domain protein
DEH18_RS23490	COG0045	succinate-CoA ligase (ADP-forming) activity
DEH18_RS23490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DEH18_RS23505	COG1802	Transcriptional regulator
DEH18_RS23510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DEH18_RS23540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DEH18_RS23570	COG0772	Belongs to the SEDS family
DEH18_RS23625	COG1175	transmembrane transport
DEH18_RS23635	COG1349	DNA-binding transcription factor activity
DEH18_RS23640	COG0673	inositol 2-dehydrogenase activity
DEH18_RS23645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS23650	COG2226	methyltransferase
DEH18_RS23655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DEH18_RS23705	COG1024	Enoyl-CoA hydratase
DEH18_RS23735	COG2040	homocysteine
DEH18_RS23745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DEH18_RS23750	COG0531	amino acid
DEH18_RS23795	COG0596	Alpha beta hydrolase
DEH18_RS23800	COG1725	Transcriptional regulator
DEH18_RS23835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DEH18_RS23845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DEH18_RS23855	COG1482	cell wall glycoprotein biosynthetic process
DEH18_RS23870	COG0515	serine threonine protein kinase
DEH18_RS23870	COG2815	serine threonine protein kinase
DEH18_RS23950	COG2188	Transcriptional regulator
DEH18_RS23970	COG1735	metal-dependent hydrolase with the TIM-barrel fold
DEH18_RS23975	COG0626	cystathionine gamma-synthase activity
DEH18_RS23980	COG3457	Alanine racemase
DEH18_RS23985	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DEH18_RS24005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DEH18_RS24020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DEH18_RS24025	COG1802	Transcriptional regulator
DEH18_RS24035	COG3938	Belongs to the proline racemase family
DEH18_RS24050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DEH18_RS24050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS24060	COG0405	Gamma-glutamyltransferase
DEH18_RS24065	COG0477	Major facilitator Superfamily
DEH18_RS24080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DEH18_RS24085	COG2222	sugar isomerase
DEH18_RS24135	COG1396	sequence-specific DNA binding
DEH18_RS24140	COG0235	Class ii aldolase
DEH18_RS24145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DEH18_RS24150	COG2267	carboxylic ester hydrolase activity
DEH18_RS24155	COG0783	Belongs to the Dps family
DEH18_RS24175	COG0640	Transcriptional regulator
DEH18_RS24195	COG1486	melibiose metabolic process
DEH18_RS24200	COG0395	ABC-type sugar transport system, permease component
DEH18_RS24205	COG1175	transmembrane transport
DEH18_RS24215	COG1940	carbohydrate kinase activity
DEH18_RS24215	COG1846	Transcriptional regulator
DEH18_RS24235	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
DEH18_RS24250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DEH18_RS24265	COG0583	DNA-binding transcription factor activity
DEH18_RS24280	COG0477	Major facilitator Superfamily
DEH18_RS24285	COG0745	RESPONSE REGULATOR receiver
DEH18_RS24290	COG2205	protein histidine kinase activity
DEH18_RS24300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DEH18_RS24300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DEH18_RS24315	COG2072	flavoprotein involved in K transport
DEH18_RS24325	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS24365	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS24370	COG0583	DNA-binding transcription factor activity
DEH18_RS24455	COG4585	Histidine kinase
DEH18_RS24465	COG0076	glutamate decarboxylase activity
DEH18_RS24475	COG0402	S-adenosylhomocysteine deaminase activity
DEH18_RS24490	COG2362	D-Aminopeptidase
DEH18_RS24500	COG1309	transcriptional regulator
DEH18_RS24520	COG0028	Belongs to the TPP enzyme family
DEH18_RS24540	COG3290	protein histidine kinase activity
DEH18_RS24545	COG4565	transcriptional regulatory protein
DEH18_RS24550	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS24585	COG1191	sigma factor activity
DEH18_RS24605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS24620	COG0596	Alpha beta hydrolase
DEH18_RS24625	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS24630	COG1802	Transcriptional regulator
DEH18_RS24650	COG0789	Transcriptional regulator
DEH18_RS24660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DEH18_RS24665	COG0531	amino acid
DEH18_RS24670	COG0569	domain protein
DEH18_RS24700	COG4591	ABC-type transport system involved in lipoprotein release permease component
DEH18_RS24700	COG1136	(ABC) transporter
DEH18_RS24710	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DEH18_RS24715	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DEH18_RS24720	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DEH18_RS24735	COG0756	dUTP diphosphatase activity
DEH18_RS24760	COG2205	protein histidine kinase activity
DEH18_RS24765	COG0745	RESPONSE REGULATOR receiver
DEH18_RS24810	COG1435	thymidine kinase activity
DEH18_RS24830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DEH18_RS24835	COG0739	heme binding
DEH18_RS24845	COG0612	Peptidase, M16
DEH18_RS24850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DEH18_RS24865	COG3290	protein histidine kinase activity
DEH18_RS24870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DEH18_RS24895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DEH18_RS24905	COG1131	(ABC) transporter
DEH18_RS24925	COG0514	ATP-dependent DNA helicase (RecQ)
DEH18_RS24940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DEH18_RS24950	COG0406	alpha-ribazole phosphatase activity
DEH18_RS24960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DEH18_RS25000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DEH18_RS25010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DEH18_RS25015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DEH18_RS25025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DEH18_RS25045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DEH18_RS25055	COG2205	protein histidine kinase activity
DEH18_RS25065	COG1126	abc transporter atp-binding protein
DEH18_RS25070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DEH18_RS25075	COG0765	amino acid transport
DEH18_RS25080	COG0765	amino acid transport
DEH18_RS25085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS25095	COG0666	response to abiotic stimulus
DEH18_RS25105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DEH18_RS25110	COG0628	permease
DEH18_RS25135	COG2207	Transcriptional regulator
DEH18_RS25135	COG1917	Cupin 2, conserved barrel domain protein
DEH18_RS25140	COG1201	RNA secondary structure unwinding
DEH18_RS25145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DEH18_RS25155	COG1396	sequence-specific DNA binding
DEH18_RS25160	COG1058	Belongs to the CinA family
DEH18_RS25160	COG1546	Belongs to the CinA family
DEH18_RS25170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DEH18_RS25180	COG1674	ftsk spoiiie
DEH18_RS25190	COG2205	protein histidine kinase activity
DEH18_RS25190	COG3437	response regulator, receiver
DEH18_RS25190	COG4999	Histidine kinase
DEH18_RS25190	COG3850	Histidine kinase
DEH18_RS25195	COG2208	phosphoserine phosphatase activity
DEH18_RS25195	COG2770	Histidine kinase
DEH18_RS25225	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DEH18_RS25230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DEH18_RS25235	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DEH18_RS25255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DEH18_RS25260	COG0612	Peptidase, M16
DEH18_RS25265	COG1185	polyribonucleotide nucleotidyltransferase activity
DEH18_RS25270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DEH18_RS25280	COG1674	ftsk spoiiie
DEH18_RS25300	COG1404	Belongs to the peptidase S8 family
DEH18_RS25315	COG1404	Belongs to the peptidase S8 family
DEH18_RS25335	COG0455	bacterial-type flagellum organization
DEH18_RS25350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DEH18_RS25355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DEH18_RS25365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DEH18_RS25380	COG0779	Required for maturation of 30S ribosomal subunits
DEH18_RS25395	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DEH18_RS25400	COG0442	prolyl-tRNA aminoacylation
DEH18_RS25415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DEH18_RS25420	COG0750	zinc metalloprotease
DEH18_RS25425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DEH18_RS25440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DEH18_RS25445	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS25450	COG2508	Transcriptional regulator
DEH18_RS25475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS25485	COG1176	ABC-type spermidine putrescine transport system, permease component I
DEH18_RS25490	COG3842	ATPase activity
DEH18_RS25500	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS25510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DEH18_RS25515	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS25525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DEH18_RS25530	COG1136	(ABC) transporter
DEH18_RS25540	COG3842	ATPase activity
DEH18_RS25555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DEH18_RS25560	COG0575	Belongs to the CDS family
DEH18_RS25565	COG0233	cytoplasmic translational termination
DEH18_RS25570	COG0528	UMP kinase activity
DEH18_RS25575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DEH18_RS25580	COG0052	Belongs to the universal ribosomal protein uS2 family
DEH18_RS25595	COG1191	sigma factor activity
DEH18_RS25605	COG0606	chelatase, subunit chli
DEH18_RS25610	COG0792	nuclease activity
DEH18_RS25625	COG0681	Belongs to the peptidase S26 family
DEH18_RS25630	COG0681	Belongs to the peptidase S26 family
DEH18_RS25640	COG0335	large ribosomal subunit rRNA binding
DEH18_RS25645	COG0336	Belongs to the RNA methyltransferase TrmD family
DEH18_RS25650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DEH18_RS25655	COG1837	Belongs to the UPF0109 family
DEH18_RS25660	COG0228	four-way junction DNA binding
DEH18_RS25670	COG0442	prolyl-tRNA aminoacylation
DEH18_RS25710	COG0477	Major facilitator Superfamily
DEH18_RS25725	COG1254	Belongs to the acylphosphatase family
DEH18_RS25735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DEH18_RS25740	COG0571	ribonuclease III activity
DEH18_RS25745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DEH18_RS25760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DEH18_RS25765	COG0742	ribosomal rna small subunit methyltransferase
DEH18_RS25775	COG1461	Dihydroxyacetone kinase
DEH18_RS25780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DEH18_RS25785	COG0351	phosphomethylpyrimidine kinase
DEH18_RS25805	COG1181	Belongs to the D-alanine--D-alanine ligase family
DEH18_RS25810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DEH18_RS25830	COG0776	regulation of translation
DEH18_RS25840	COG0066	3-isopropylmalate dehydratase activity
DEH18_RS25845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DEH18_RS25850	COG1414	Transcriptional regulator
DEH18_RS25870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DEH18_RS25875	COG0179	Fumarylacetoacetate (FAA) hydrolase
DEH18_RS25890	COG2018	Roadblock/LC7 domain
DEH18_RS25910	COG2018	Roadblock/LC7 domain
DEH18_RS25930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DEH18_RS25935	COG5492	domain, Protein
DEH18_RS25940	COG0832	Belongs to the urease beta subunit family
DEH18_RS25940	COG0831	urea catabolic process
DEH18_RS25945	COG0804	urea catabolic process
DEH18_RS25950	COG2957	Belongs to the agmatine deiminase family
DEH18_RS25960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DEH18_RS25965	COG3540	Alkaline phosphatase
DEH18_RS25970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DEH18_RS25975	COG0473	3-isopropylmalate dehydrogenase activity
DEH18_RS25985	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS25990	COG0506	proline dehydrogenase activity
DEH18_RS25995	COG3835	regulator
DEH18_RS26000	COG0596	Alpha beta hydrolase
DEH18_RS26010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DEH18_RS26015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DEH18_RS26020	COG0440	acetolactate synthase activity
DEH18_RS26035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DEH18_RS26040	COG0667	Aldo Keto reductase
DEH18_RS26065	COG2409	Drug exporters of the RND superfamily
DEH18_RS26085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DEH18_RS26100	COG1940	carbohydrate kinase activity
DEH18_RS26125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DEH18_RS26145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DEH18_RS26155	COG0154	amidase activity
DEH18_RS26160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DEH18_RS26170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DEH18_RS26180	COG4221	oxidoreductase activity
DEH18_RS26185	COG1077	Cell shape determining protein MreB Mrl
DEH18_RS26200	COG1611	Belongs to the LOG family
DEH18_RS26205	COG0482	sulfurtransferase activity
DEH18_RS26225	COG0783	Belongs to the Dps family
DEH18_RS26235	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS26240	COG4608	Belongs to the ABC transporter superfamily
DEH18_RS26245	COG0444	Belongs to the ABC transporter superfamily
DEH18_RS26255	COG4166	transmembrane transport
DEH18_RS26260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DEH18_RS26285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DEH18_RS26290	COG0509	glycine decarboxylation via glycine cleavage system
DEH18_RS26295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DEH18_RS26300	COG1760	l-serine dehydratase
DEH18_RS26310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS26370	COG2860	membrane
DEH18_RS26385	COG0386	Belongs to the glutathione peroxidase family
DEH18_RS26410	COG1254	Belongs to the acylphosphatase family
DEH18_RS26425	COG0583	DNA-binding transcription factor activity
DEH18_RS26430	COG0156	8-amino-7-oxononanoate synthase activity
DEH18_RS26435	COG1063	alcohol dehydrogenase
DEH18_RS26445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DEH18_RS26450	COG1609	Transcriptional regulator
DEH18_RS26455	COG1957	nucleoside hydrolase
DEH18_RS26490	COG1132	(ABC) transporter
DEH18_RS26510	COG0366	Alpha amylase catalytic
DEH18_RS26520	COG3281	Trehalose synthase
DEH18_RS26525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DEH18_RS26535	COG3290	protein histidine kinase activity
DEH18_RS26540	COG4565	transcriptional regulatory protein
DEH18_RS26545	COG3469	chitinase activity
DEH18_RS26580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DEH18_RS26590	COG0583	DNA-binding transcription factor activity
DEH18_RS26595	COG2814	Major facilitator Superfamily
DEH18_RS26600	COG0515	serine threonine protein kinase
DEH18_RS26600	COG2815	serine threonine protein kinase
DEH18_RS26605	COG0205	6-phosphofructokinase activity
DEH18_RS26610	COG0280	phosphate acetyltransferase
DEH18_RS26610	COG0857	belongs to the CobB CobQ family
DEH18_RS26615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DEH18_RS26710	COG2205	protein histidine kinase activity
DEH18_RS26715	COG0745	RESPONSE REGULATOR receiver
DEH18_RS26730	COG0183	Belongs to the thiolase family
DEH18_RS26785	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DEH18_RS26800	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS26845	COG4585	Histidine kinase
DEH18_RS26850	COG2197	response regulator
DEH18_RS26875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DEH18_RS26880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DEH18_RS26885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DEH18_RS26890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DEH18_RS26895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DEH18_RS26900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DEH18_RS26905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DEH18_RS26925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DEH18_RS26935	COG2890	protein-(glutamine-N5) methyltransferase activity
DEH18_RS26940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DEH18_RS26945	COG0254	rRNA binding
DEH18_RS26960	COG0083	homoserine kinase activity
DEH18_RS26965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DEH18_RS26975	COG0019	diaminopimelate decarboxylase activity
DEH18_RS26980	COG0018	arginyl-trna synthetase
DEH18_RS26980	COG0018	arginyl-trna synthetase
DEH18_RS26995	COG0726	polysaccharide deacetylase
DEH18_RS27060	COG0515	serine threonine protein kinase
DEH18_RS27060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DEH18_RS27065	COG0791	NLP P60 protein
DEH18_RS27110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DEH18_RS27120	COG0745	RESPONSE REGULATOR receiver
DEH18_RS27125	COG2205	protein histidine kinase activity
DEH18_RS27130	COG0567	Dehydrogenase, E1 component
DEH18_RS27130	COG0508	dehydrogenase complex catalyzes the overall conversion of
DEH18_RS27155	COG2255	four-way junction helicase activity
DEH18_RS27170	COG2255	four-way junction helicase activity
DEH18_RS27220	COG4585	Histidine kinase
DEH18_RS27240	COG1309	transcriptional regulator
DEH18_RS27255	COG0604	alcohol dehydrogenase
DEH18_RS27275	COG0765	amino acid transport
DEH18_RS27285	COG0281	malic enzyme
DEH18_RS27290	COG4106	trans-aconitate 2-methyltransferase activity
DEH18_RS27310	COG2264	protein methyltransferase activity
DEH18_RS27320	COG0583	DNA-binding transcription factor activity
DEH18_RS27330	COG0494	nUDIX hydrolase
DEH18_RS27350	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DEH18_RS27370	COG1597	lipid kinase activity
DEH18_RS27385	COG0235	Class ii aldolase
DEH18_RS27390	COG2390	Transcriptional regulator
DEH18_RS27400	COG1472	Belongs to the glycosyl hydrolase 3 family
DEH18_RS27410	COG1175	transmembrane transport
DEH18_RS27420	COG2188	Transcriptional regulator
DEH18_RS27425	COG1966	Carbon starvation protein
DEH18_RS27455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DEH18_RS27460	COG0242	peptide deformylase activity
DEH18_RS27480	COG5662	AntiSigma factor
DEH18_RS27485	COG1595	DNA-templated transcription, initiation
DEH18_RS27495	COG2135	peptidase activity
DEH18_RS27505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DEH18_RS27510	COG1162	GTPase activity
DEH18_RS27515	COG2076	Multidrug Resistance protein
DEH18_RS27525	COG0483	inositol monophosphate 1-phosphatase activity
DEH18_RS27535	COG0753	catalase activity
DEH18_RS27580	COG1615	UPF0182 protein
DEH18_RS27590	COG3480	Lon protease (S16) C-terminal proteolytic domain
DEH18_RS27630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DEH18_RS27665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS27690	COG0596	Alpha beta hydrolase
DEH18_RS27755	COG0513	Belongs to the DEAD box helicase family
DEH18_RS27760	COG0596	Alpha beta hydrolase
DEH18_RS27765	COG2095	MarC family integral membrane protein
DEH18_RS27770	COG0613	PHP domain protein
DEH18_RS27780	COG2814	Major facilitator Superfamily
DEH18_RS27790	COG0598	Magnesium transport protein CorA
DEH18_RS27805	COG2239	Acts as a magnesium transporter
DEH18_RS27825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DEH18_RS27830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DEH18_RS27840	COG1595	DNA-templated transcription, initiation
DEH18_RS27855	COG1024	Enoyl-CoA hydratase
DEH18_RS27860	COG0519	Catalyzes the synthesis of GMP from XMP
DEH18_RS27870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DEH18_RS27880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DEH18_RS27915	COG2197	response regulator
DEH18_RS27920	COG4585	Histidine kinase
DEH18_RS27930	COG1131	(ABC) transporter
DEH18_RS27945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DEH18_RS27960	COG4608	Belongs to the ABC transporter superfamily
DEH18_RS27965	COG0444	Belongs to the ABC transporter superfamily
DEH18_RS27990	COG4608	Belongs to the ABC transporter superfamily
DEH18_RS27995	COG0444	Belongs to the ABC transporter superfamily
DEH18_RS28000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DEH18_RS28005	COG0601	transmembrane transport
DEH18_RS28010	COG4166	transmembrane transport
DEH18_RS28015	COG4608	Belongs to the ABC transporter superfamily
DEH18_RS28020	COG0444	Belongs to the ABC transporter superfamily
DEH18_RS28025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DEH18_RS28095	COG1053	succinate dehydrogenase
DEH18_RS28105	COG4585	Histidine kinase
DEH18_RS28125	COG0438	transferase activity, transferring glycosyl groups
DEH18_RS28130	COG2197	response regulator
DEH18_RS28140	COG2208	phosphoserine phosphatase activity
DEH18_RS28185	COG0012	GTP binding
DEH18_RS28195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DEH18_RS28205	COG1570	exodeoxyribonuclease VII activity
DEH18_RS28210	COG1722	exodeoxyribonuclease VII activity
DEH18_RS28215	COG0778	Nitroreductase
DEH18_RS28240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DEH18_RS28240	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DEH18_RS28255	COG0114	fumarate hydratase activity
DEH18_RS28265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DEH18_RS28275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DEH18_RS28280	COG0450	alkyl hydroperoxide reductase
DEH18_RS28305	COG1136	(ABC) transporter
DEH18_RS28335	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DEH18_RS28340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DEH18_RS28345	COG0667	Aldo Keto reductase
DEH18_RS28365	COG0640	Transcriptional regulator
DEH18_RS28385	COG2885	chlorophyll binding
DEH18_RS28405	COG2814	Major facilitator Superfamily
DEH18_RS28410	COG2188	Transcriptional regulator
DEH18_RS28415	COG1940	carbohydrate kinase activity
DEH18_RS28420	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DEH18_RS28500	COG2610	gluconate transmembrane transporter activity
DEH18_RS28525	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DEH18_RS28540	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DEH18_RS28550	COG0436	Aminotransferase
DEH18_RS28565	COG1331	Highly conserved protein containing a thioredoxin domain
DEH18_RS28625	COG0189	ligase activity
DEH18_RS28625	COG4067	protein conserved in archaea
DEH18_RS28635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DEH18_RS28705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DEH18_RS28720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DEH18_RS28725	COG0800	Aldolase
DEH18_RS28735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DEH18_RS28745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DEH18_RS28780	COG2986	histidine ammonia-lyase
DEH18_RS28790	COG1024	Enoyl-CoA hydratase
DEH18_RS28795	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DEH18_RS28800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DEH18_RS28800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DEH18_RS28805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DEH18_RS28815	COG0424	maF-like protein
DEH18_RS28825	COG4770	biotin carboxylase activity
DEH18_RS28850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DEH18_RS28895	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS28900	COG1733	regulation of RNA biosynthetic process
DEH18_RS28935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DEH18_RS28935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DEH18_RS28940	COG1595	DNA-templated transcription, initiation
DEH18_RS28945	COG0745	RESPONSE REGULATOR receiver
DEH18_RS28950	COG2205	protein histidine kinase activity
DEH18_RS28975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DEH18_RS28985	COG2226	methyltransferase
DEH18_RS28990	COG0583	DNA-binding transcription factor activity
DEH18_RS28995	COG2814	Major facilitator Superfamily
DEH18_RS29030	COG1473	amidohydrolase
DEH18_RS29030	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DEH18_RS29040	COG2089	acid synthase
DEH18_RS29065	COG2084	Dehydrogenase
DEH18_RS29075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS29100	COG1595	DNA-templated transcription, initiation
DEH18_RS29105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DEH18_RS29115	COG2009	succinate dehydrogenase
DEH18_RS29155	COG1408	metallophosphoesterase
DEH18_RS29170	COG1295	ribonuclease BN
DEH18_RS29180	COG0180	Tryptophanyl-tRNA synthetase
DEH18_RS29185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DEH18_RS29190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DEH18_RS29200	COG2226	methyltransferase
DEH18_RS29240	COG0135	phosphoribosylanthranilate isomerase activity
DEH18_RS29245	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS29250	COG0662	Cupin 2, conserved barrel domain protein
DEH18_RS29255	COG0159	tryptophan synthase activity
DEH18_RS29260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DEH18_RS29280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS29285	COG0156	8-amino-7-oxononanoate synthase activity
DEH18_RS29290	COG3629	intracellular signal transduction
DEH18_RS29320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DEH18_RS29335	COG2072	flavoprotein involved in K transport
DEH18_RS29365	COG0702	epimerase
DEH18_RS29420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS29420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DEH18_RS29425	COG1505	serine-type exopeptidase activity
DEH18_RS29485	COG2226	methyltransferase
DEH18_RS29510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS29515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS29545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DEH18_RS29570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DEH18_RS29575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DEH18_RS29585	COG2072	flavoprotein involved in K transport
DEH18_RS29590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DEH18_RS29595	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS29600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DEH18_RS29605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS29615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS29620	COG1309	transcriptional regulator
DEH18_RS29630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DEH18_RS29645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DEH18_RS29670	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS29680	COG0644	oxidoreductase
DEH18_RS29695	COG1073	alpha beta
DEH18_RS29740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DEH18_RS29760	COG4176	ABC-type proline glycine betaine transport system permease component
DEH18_RS29765	COG0517	IMP dehydrogenase activity
DEH18_RS29765	COG4175	Glycine betaine
DEH18_RS29785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DEH18_RS29810	COG0039	L-malate dehydrogenase activity
DEH18_RS29825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DEH18_RS29850	COG0138	bifunctional purine biosynthesis protein purh
DEH18_RS29875	COG2197	response regulator
DEH18_RS29880	COG4585	Histidine kinase
DEH18_RS29890	COG0045	succinate-CoA ligase (ADP-forming) activity
DEH18_RS29895	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DEH18_RS29905	COG0714	Associated with various cellular activities
DEH18_RS29920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DEH18_RS29925	COG0739	heme binding
DEH18_RS29980	COG1309	transcriptional regulator
DEH18_RS29985	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS30000	COG1073	alpha beta
DEH18_RS30025	COG2197	response regulator
DEH18_RS30065	COG0662	Cupin 2, conserved barrel domain protein
DEH18_RS30085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DEH18_RS30115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DEH18_RS30115	COG0519	Catalyzes the synthesis of GMP from XMP
DEH18_RS30120	COG1605	Chorismate mutase
DEH18_RS30130	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS30135	COG1309	transcriptional regulator
DEH18_RS30155	COG2815	serine threonine protein kinase
DEH18_RS30155	COG0515	serine threonine protein kinase
DEH18_RS30160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DEH18_RS30170	COG0516	GMP reductase activity
DEH18_RS30180	COG1595	DNA-templated transcription, initiation
DEH18_RS30185	COG2197	response regulator
DEH18_RS30195	COG0583	DNA-binding transcription factor activity
DEH18_RS30205	COG4221	oxidoreductase activity
DEH18_RS30220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DEH18_RS30265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DEH18_RS30275	COG0456	acetyltransferase
DEH18_RS30275	COG1214	PFAM Peptidase M22, glycoprotease
DEH18_RS30295	COG0802	atpase or kinase
DEH18_RS30305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DEH18_RS30310	COG2318	DinB family
DEH18_RS30325	COG0736	holo-[acyl-carrier-protein] synthase activity
DEH18_RS30330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DEH18_RS30340	COG1072	(Pantothenic acid kinase))
DEH18_RS30345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DEH18_RS30350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DEH18_RS30355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DEH18_RS30370	COG2268	Band 7 protein
DEH18_RS30375	COG0101	tRNA pseudouridine synthase activity
DEH18_RS30380	COG0203	ribosomal protein L17
DEH18_RS30385	COG0202	RNA polymerase activity
DEH18_RS30390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DEH18_RS30395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DEH18_RS30400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DEH18_RS30405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DEH18_RS30410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DEH18_RS30420	COG0563	adenylate kinase activity
DEH18_RS30430	COG0200	Binds to the 23S rRNA
DEH18_RS30435	COG1841	ribosomal large subunit assembly
DEH18_RS30440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DEH18_RS30445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DEH18_RS30450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DEH18_RS30455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DEH18_RS30460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DEH18_RS30465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DEH18_RS30470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DEH18_RS30475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DEH18_RS30480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DEH18_RS30485	COG0255	Belongs to the universal ribosomal protein uL29 family
DEH18_RS30490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DEH18_RS30495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DEH18_RS30500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DEH18_RS30505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DEH18_RS30510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DEH18_RS30515	COG0089	rRNA binding
DEH18_RS30520	COG0088	Forms part of the polypeptide exit tunnel
DEH18_RS30525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DEH18_RS30530	COG0051	transcription antitermination factor activity, RNA binding
DEH18_RS30535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DEH18_RS30540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DEH18_RS30545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DEH18_RS30550	COG0049	tRNA binding
DEH18_RS30555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DEH18_RS30560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DEH18_RS30565	COG0085	RNA polymerase activity
DEH18_RS30570	COG0222	ribosome binding
DEH18_RS30575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DEH18_RS30585	COG0081	regulation of translation
DEH18_RS30590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DEH18_RS30595	COG0250	Participates in transcription elongation, termination and antitermination
DEH18_RS30610	COG0436	Aminotransferase
DEH18_RS30615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DEH18_RS30630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DEH18_RS30640	COG2030	dehydratase
DEH18_RS30645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DEH18_RS30665	COG0702	epimerase
DEH18_RS30670	COG2197	response regulator
DEH18_RS30675	COG4585	Histidine kinase
DEH18_RS30695	COG2188	Transcriptional regulator
DEH18_RS30760	COG1051	belongs to the nudix hydrolase family
DEH18_RS30760	COG1056	cytidyltransferase-related domain
DEH18_RS30805	COG1666	GTP binding
DEH18_RS30810	COG3304	Inner membrane component domain
DEH18_RS30815	COG0501	Belongs to the peptidase M48B family
DEH18_RS30825	COG1007	ATP synthesis coupled electron transport
DEH18_RS30835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DEH18_RS30840	COG0713	ATP synthesis coupled electron transport
DEH18_RS30845	COG0839	Belongs to the complex I subunit 6 family
DEH18_RS30850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS30855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DEH18_RS30860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS30865	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS30870	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS30875	COG4585	Histidine kinase
DEH18_RS30885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DEH18_RS30885	COG0674	pyruvate-flavodoxin oxidoreductase activity
DEH18_RS30890	COG1013	pyruvate-flavodoxin oxidoreductase activity
DEH18_RS30910	COG3209	COG3209 Rhs family protein
DEH18_RS30940	COG3104	oligopeptide transport
DEH18_RS30965	COG0179	Fumarylacetoacetate (FAA) hydrolase
DEH18_RS30970	COG0514	ATP-dependent DNA helicase (RecQ)
DEH18_RS30975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DEH18_RS30985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DEH18_RS31000	COG1007	ATP synthesis coupled electron transport
DEH18_RS31010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DEH18_RS31015	COG0713	ATP synthesis coupled electron transport
DEH18_RS31020	COG0839	Belongs to the complex I subunit 6 family
DEH18_RS31025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS31030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DEH18_RS31035	COG1034	ATP synthesis coupled electron transport
DEH18_RS31040	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DEH18_RS31050	COG0649	NAD binding
DEH18_RS31055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS31060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DEH18_RS31085	COG2226	methyltransferase
DEH18_RS31090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DEH18_RS31100	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DEH18_RS31120	COG0698	ribose 5-phosphate isomerase
DEH18_RS31125	COG2376	Dihydroxyacetone kinase
DEH18_RS31130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DEH18_RS31140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DEH18_RS31165	COG4608	Belongs to the ABC transporter superfamily
DEH18_RS31175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DEH18_RS31180	COG0601	transmembrane transport
DEH18_RS31185	COG4166	transmembrane transport
DEH18_RS31200	COG1309	transcriptional regulator
DEH18_RS31205	COG3246	L-lysine catabolic process to acetate
DEH18_RS31210	COG1250	3-hydroxyacyl-CoA dehydrogenase
DEH18_RS31220	COG2175	clavaminate synthase activity
DEH18_RS31235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DEH18_RS31270	COG1573	uracil-dna glycosylase
DEH18_RS31275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DEH18_RS31285	COG0163	prenyltransferase activity
DEH18_RS31300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DEH18_RS31305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DEH18_RS31335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DEH18_RS31340	COG1333	cytochrome c biogenesis protein
DEH18_RS31350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DEH18_RS31355	COG0406	alpha-ribazole phosphatase activity
DEH18_RS31360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DEH18_RS31375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DEH18_RS31385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DEH18_RS31390	COG1742	UPF0060 membrane protein
DEH18_RS31405	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DEH18_RS31410	COG0018	arginyl-trna synthetase
DEH18_RS31415	COG0113	porphobilinogen synthase activity
DEH18_RS31420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DEH18_RS31420	COG1648	precorrin-2 dehydrogenase activity
DEH18_RS31425	COG0181	hydroxymethylbilane synthase activity
DEH18_RS31430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DEH18_RS31435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DEH18_RS31445	COG0560	Phosphoserine phosphatase
DEH18_RS31480	COG0123	including yeast histone deacetylase and acetoin utilization protein
DEH18_RS31505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DEH18_RS31515	COG0842	Transport permease protein
DEH18_RS31515	COG1129	ABC transporter
DEH18_RS31520	COG0659	secondary active sulfate transmembrane transporter activity
DEH18_RS31525	COG2409	Drug exporters of the RND superfamily
DEH18_RS31545	COG0129	dihydroxy-acid dehydratase activity
DEH18_RS31550	COG1082	Xylose isomerase domain protein TIM barrel
DEH18_RS31555	COG0248	Ppx GppA phosphatase
DEH18_RS31575	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DEH18_RS31585	COG1194	a g-specific adenine glycosylase
DEH18_RS31595	COG1309	transcriptional regulator
DEH18_RS31600	COG0739	heme binding
DEH18_RS31615	COG0542	response to heat
DEH18_RS31625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DEH18_RS31640	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DEH18_RS31650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DEH18_RS31655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DEH18_RS31670	COG2197	response regulator
DEH18_RS31685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DEH18_RS31690	COG1125	glycine betaine transport
DEH18_RS31690	COG0517	IMP dehydrogenase activity
DEH18_RS31695	COG1174	glycine betaine transport
DEH18_RS31700	COG1174	glycine betaine transport
DEH18_RS31715	COG0649	NAD binding
DEH18_RS31730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DEH18_RS31740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DEH18_RS31745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DEH18_RS31755	COG0302	gtp cyclohydrolase
DEH18_RS31770	COG0037	tRNA processing
DEH18_RS31785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DEH18_RS31795	COG0789	Transcriptional regulator
DEH18_RS31805	COG2318	DinB family
DEH18_RS31810	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS31830	COG2197	response regulator
DEH18_RS31835	COG4585	Histidine kinase
DEH18_RS31845	COG1136	(ABC) transporter
DEH18_RS31850	COG1132	(ABC) transporter
DEH18_RS31855	COG1077	Cell shape determining protein MreB Mrl
DEH18_RS31875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DEH18_RS31895	COG1846	Transcriptional regulator
DEH18_RS31910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DEH18_RS31915	COG1215	transferase activity, transferring glycosyl groups
DEH18_RS31930	COG0456	acetyltransferase
DEH18_RS31935	COG2205	protein histidine kinase activity
DEH18_RS31940	COG0745	RESPONSE REGULATOR receiver
DEH18_RS31945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DEH18_RS31950	COG1609	Transcriptional regulator
DEH18_RS31955	COG0745	RESPONSE REGULATOR receiver
DEH18_RS31990	COG2897	thiosulfate sulfurtransferase activity
DEH18_RS32010	COG3485	protocatechuate 3,4-dioxygenase
DEH18_RS32020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DEH18_RS32025	COG1490	D-aminoacyl-tRNA deacylase activity
DEH18_RS32040	COG4552	Acetyltransferase involved in intracellular survival and related
DEH18_RS32055	COG4257	antibiotic catabolic process
DEH18_RS32060	COG0488	(ABC) transporter
DEH18_RS32065	COG1309	transcriptional regulator
DEH18_RS32070	COG1309	transcriptional regulator
DEH18_RS32105	COG1733	regulation of RNA biosynthetic process
DEH18_RS32155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DEH18_RS32160	COG0306	phosphate transporter
DEH18_RS32170	COG1937	Protein conserved in bacteria
DEH18_RS32190	COG0671	phosphoesterase, PA-phosphatase related
DEH18_RS32195	COG1196	nuclear chromosome segregation
DEH18_RS32195	COG0739	heme binding
DEH18_RS32195	COG0741	lytic transglycosylase activity
DEH18_RS32285	COG1846	Transcriptional regulator
DEH18_RS32330	COG0579	oxidoreductase
DEH18_RS32335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DEH18_RS32355	COG3467	pyridoxamine 5'-phosphate
DEH18_RS32360	COG0667	Aldo Keto reductase
DEH18_RS32365	COG1196	nuclear chromosome segregation
DEH18_RS32365	COG0741	lytic transglycosylase activity
DEH18_RS32365	COG0739	heme binding
DEH18_RS32385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DEH18_RS32395	COG2124	cytochrome p450
DEH18_RS32415	COG2124	cytochrome p450
DEH18_RS32440	COG0702	epimerase
DEH18_RS32445	COG2409	Drug exporters of the RND superfamily
DEH18_RS32455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DEH18_RS32460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DEH18_RS32475	COG3291	Pkd domain containing protein
DEH18_RS32485	COG0583	DNA-binding transcription factor activity
DEH18_RS32490	COG2234	aminopeptidase activity
DEH18_RS32545	COG1216	Glycosyl transferase, family 2
DEH18_RS32550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DEH18_RS32565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DEH18_RS32570	COG1454	alcohol dehydrogenase
DEH18_RS32600	COG0515	serine threonine protein kinase
DEH18_RS32610	COG2197	response regulator
DEH18_RS32615	COG1215	transferase activity, transferring glycosyl groups
DEH18_RS32665	COG0513	Belongs to the DEAD box helicase family
DEH18_RS32705	COG0583	DNA-binding transcription factor activity
DEH18_RS32730	COG0785	Cytochrome C biogenesis protein
DEH18_RS32735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DEH18_RS32735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DEH18_RS32750	COG1643	Atp-dependent helicase
DEH18_RS32785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DEH18_RS32865	COG0629	single-stranded DNA binding
DEH18_RS32995	COG3942	CHAP domain
DEH18_RS32995	COG1388	LysM domain
DEH18_RS33060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DEH18_RS33065	COG0047	phosphoribosylformylglycinamidine synthase activity
DEH18_RS33070	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DEH18_RS33105	COG2197	response regulator
DEH18_RS33120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DEH18_RS33125	COG2340	Cysteine-rich secretory protein family
DEH18_RS33140	COG0151	Belongs to the GarS family
DEH18_RS33165	COG1802	Transcriptional regulator
DEH18_RS33190	COG1280	lysine exporter protein (LysE YggA)
DEH18_RS33195	COG1522	sequence-specific DNA binding
DEH18_RS33230	COG3559	Exporter of polyketide antibiotics
DEH18_RS33235	COG1131	(ABC) transporter
DEH18_RS33265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DEH18_RS33305	COG3483	tryptophan 2,3-dioxygenase activity
DEH18_RS33315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DEH18_RS33320	COG1263	PTS System
DEH18_RS33320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DEH18_RS33325	COG0191	fructose-bisphosphate aldolase activity
DEH18_RS33330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DEH18_RS33370	COG0542	response to heat
DEH18_RS33380	COG0789	Transcriptional regulator
DEH18_RS33385	COG0484	heat shock protein binding
DEH18_RS33390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DEH18_RS33395	COG0443	Heat shock 70 kDa protein
DEH18_RS33400	COG2181	nitrate reductase activity
DEH18_RS33400	COG0247	lactate metabolic process
DEH18_RS33420	COG2755	lipolytic protein G-D-S-L family
DEH18_RS33435	COG0717	Belongs to the dCTP deaminase family
DEH18_RS33465	COG1595	DNA-templated transcription, initiation
DEH18_RS33495	COG4152	abc transporter atp-binding protein
DEH18_RS33500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DEH18_RS33515	COG2807	transmembrane transport
DEH18_RS33535	COG1131	(ABC) transporter
DEH18_RS33555	COG0789	Transcriptional regulator
DEH18_RS33580	COG2226	methyltransferase
DEH18_RS33630	COG0598	Magnesium transport protein CorA
DEH18_RS33635	COG1252	NADH dehydrogenase
DEH18_RS33655	COG1028	Short-chain dehydrogenase reductase Sdr
DEH18_RS33675	COG0477	Major facilitator Superfamily
DEH18_RS33680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DEH18_RS33695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DEH18_RS33710	COG1960	acyl-CoA dehydrogenase activity
DEH18_RS33715	COG1362	aminopeptidase activity
DEH18_RS33740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DEH18_RS33745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DEH18_RS33750	COG2080	2 iron, 2 sulfur cluster binding
DEH18_RS33760	COG1012	belongs to the aldehyde dehydrogenase family
DEH18_RS33785	COG0501	Belongs to the peptidase M48B family
DEH18_RS33790	COG0561	phosphatase activity
DEH18_RS33795	COG4988	ABC transporter
DEH18_RS33800	COG1294	oxidase, subunit
DEH18_RS33805	COG1271	oxidase subunit
DEH18_RS33810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DEH18_RS33815	COG1609	Transcriptional regulator
DEH18_RS33830	COG0626	cystathionine gamma-synthase activity
DEH18_RS33840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DEH18_RS33845	COG1950	PFAM Membrane protein of
DEH18_RS33850	COG0662	Cupin 2, conserved barrel domain protein
DEH18_RS33865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DEH18_RS33920	COG0789	Transcriptional regulator
DEH18_RS33935	COG0242	peptide deformylase activity
DEH18_RS33950	COG0305	Participates in initiation and elongation during chromosome replication
DEH18_RS33955	COG0534	Mate efflux family protein
DEH18_RS33960	COG0359	binds to the 23S rRNA
DEH18_RS33965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DEH18_RS33970	COG0629	single-stranded DNA binding
DEH18_RS33975	COG0360	Binds together with S18 to 16S ribosomal RNA
DEH18_RS34005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DEH18_RS34040	COG1595	DNA-templated transcription, initiation