locus-tag	class	description
C6376_RS00025	COG0300	oxidoreductase activity
C6376_RS00025	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS00025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6376_RS00025	COG3321	synthase
C6376_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS00040	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS00065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6376_RS00075	COG0569	domain protein
C6376_RS00110	COG0756	dUTP diphosphatase activity
C6376_RS00135	COG2205	protein histidine kinase activity
C6376_RS00140	COG0745	RESPONSE REGULATOR receiver
C6376_RS00150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6376_RS00185	COG1435	thymidine kinase activity
C6376_RS00200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6376_RS00200	COG0045	succinate-CoA ligase (ADP-forming) activity
C6376_RS00200	COG1042	CoA-binding domain protein
C6376_RS00210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6376_RS00215	COG1802	Transcriptional regulator
C6376_RS00230	COG0612	Peptidase, M16
C6376_RS00235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6376_RS00255	COG3290	protein histidine kinase activity
C6376_RS00260	COG4565	transcriptional regulatory protein
C6376_RS00270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6376_RS00280	COG4565	transcriptional regulatory protein
C6376_RS00285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6376_RS00295	COG2197	response regulator
C6376_RS00310	COG0187	DNA topoisomerase II activity
C6376_RS00325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6376_RS00330	COG1802	Transcriptional regulator
C6376_RS00375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6376_RS00395	COG0588	phosphoglycerate mutase activity
C6376_RS00410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6376_RS00415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6376_RS00420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6376_RS00445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6376_RS00455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6376_RS00460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6376_RS00470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6376_RS00490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6376_RS00515	COG2205	protein histidine kinase activity
C6376_RS00520	COG0745	RESPONSE REGULATOR receiver
C6376_RS00525	COG1126	abc transporter atp-binding protein
C6376_RS00530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6376_RS00535	COG0765	amino acid transport
C6376_RS00540	COG0765	amino acid transport
C6376_RS00545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6376_RS00555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6376_RS00565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6376_RS00575	COG0628	permease
C6376_RS00605	COG1201	RNA secondary structure unwinding
C6376_RS00610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6376_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS00625	COG0783	Belongs to the Dps family
C6376_RS00630	COG1396	sequence-specific DNA binding
C6376_RS00635	COG1546	Belongs to the CinA family
C6376_RS00635	COG1058	Belongs to the CinA family
C6376_RS00645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6376_RS00655	COG1674	ftsk spoiiie
C6376_RS00665	COG2205	protein histidine kinase activity
C6376_RS00665	COG0784	Response regulator, receiver
C6376_RS00675	COG2208	phosphoserine phosphatase activity
C6376_RS00675	COG2770	Histidine kinase
C6376_RS00705	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C6376_RS00710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6376_RS00715	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C6376_RS00735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6376_RS00740	COG0612	Peptidase, M16
C6376_RS00745	COG1185	polyribonucleotide nucleotidyltransferase activity
C6376_RS00750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6376_RS00765	COG1674	ftsk spoiiie
C6376_RS00790	COG2188	Transcriptional regulator
C6376_RS00805	COG1404	Belongs to the peptidase S8 family
C6376_RS00870	COG1404	Belongs to the peptidase S8 family
C6376_RS00875	COG3266	domain, Protein
C6376_RS00890	COG0455	bacterial-type flagellum organization
C6376_RS00905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6376_RS00910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6376_RS00920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6376_RS00935	COG0779	Required for maturation of 30S ribosomal subunits
C6376_RS00950	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
C6376_RS00955	COG0442	prolyl-tRNA aminoacylation
C6376_RS00970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6376_RS00975	COG0750	zinc metalloprotease
C6376_RS00980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6376_RS01025	COG0395	ABC-type sugar transport system, permease component
C6376_RS01030	COG4209	transmembrane transport
C6376_RS01070	COG2508	Transcriptional regulator
C6376_RS01070	COG2508	Transcriptional regulator
C6376_RS01080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6376_RS01085	COG1177	transmembrane transport
C6376_RS01095	COG3842	ATPase activity
C6376_RS01125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6376_RS01165	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS01175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6376_RS01205	COG3842	ATPase activity
C6376_RS01210	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C6376_RS01220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6376_RS01230	COG0575	Belongs to the CDS family
C6376_RS01235	COG0233	cytoplasmic translational termination
C6376_RS01240	COG0528	UMP kinase activity
C6376_RS01245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6376_RS01250	COG0052	Belongs to the universal ribosomal protein uS2 family
C6376_RS01270	COG1191	sigma factor activity
C6376_RS01285	COG0792	nuclease activity
C6376_RS01295	COG0494	nUDIX hydrolase
C6376_RS01305	COG0681	Belongs to the peptidase S26 family
C6376_RS01310	COG0681	Belongs to the peptidase S26 family
C6376_RS01320	COG0335	large ribosomal subunit rRNA binding
C6376_RS01325	COG0336	Belongs to the RNA methyltransferase TrmD family
C6376_RS01330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6376_RS01335	COG1837	Belongs to the UPF0109 family
C6376_RS01340	COG0228	four-way junction DNA binding
C6376_RS01360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6376_RS01370	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C6376_RS01405	COG0477	Major facilitator Superfamily
C6376_RS01410	COG1196	nuclear chromosome segregation
C6376_RS01420	COG1254	Belongs to the acylphosphatase family
C6376_RS01425	COG2340	Cysteine-rich secretory protein family
C6376_RS01430	COG0655	NAD(P)H dehydrogenase (quinone) activity
C6376_RS01435	COG1733	regulation of RNA biosynthetic process
C6376_RS01440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6376_RS01445	COG0571	ribonuclease III activity
C6376_RS01450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6376_RS01465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6376_RS01470	COG0742	ribosomal rna small subunit methyltransferase
C6376_RS01480	COG0326	Molecular chaperone. Has ATPase activity
C6376_RS01490	COG1461	Dihydroxyacetone kinase
C6376_RS01495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6376_RS01500	COG0351	phosphomethylpyrimidine kinase
C6376_RS01520	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6376_RS01525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6376_RS01535	COG1920	GTP binding
C6376_RS01545	COG0776	regulation of translation
C6376_RS01555	COG0066	3-isopropylmalate dehydratase activity
C6376_RS01560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6376_RS01565	COG1414	Transcriptional regulator
C6376_RS01575	COG0789	Transcriptional regulator
C6376_RS01615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6376_RS01620	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6376_RS01630	COG5002	protein histidine kinase activity
C6376_RS01635	COG2018	Roadblock/LC7 domain
C6376_RS01655	COG2018	Roadblock/LC7 domain
C6376_RS01675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6376_RS01700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6376_RS01705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6376_RS01710	COG0473	3-isopropylmalate dehydrogenase activity
C6376_RS01725	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS01730	COG0506	proline dehydrogenase activity
C6376_RS01735	COG2508	Transcriptional regulator
C6376_RS01745	COG0477	Major facilitator Superfamily
C6376_RS01750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6376_RS01755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6376_RS01760	COG0440	acetolactate synthase activity
C6376_RS01770	COG5001	Diguanylate cyclase
C6376_RS01780	COG0667	Aldo Keto reductase
C6376_RS01785	COG2133	pyrroloquinoline quinone binding
C6376_RS01795	COG1672	PFAM Archaeal ATPase
C6376_RS01795	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C6376_RS01810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6376_RS01815	COG2409	Drug exporters of the RND superfamily
C6376_RS01825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6376_RS01835	COG0154	amidase activity
C6376_RS01840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6376_RS01850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6376_RS01860	COG4221	oxidoreductase activity
C6376_RS01885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C6376_RS01915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C6376_RS01930	COG0482	sulfurtransferase activity
C6376_RS01935	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6376_RS01965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C6376_RS01970	COG2860	membrane
C6376_RS01975	COG4608	Belongs to the ABC transporter superfamily
C6376_RS01980	COG0444	Belongs to the ABC transporter superfamily
C6376_RS01990	COG0747	negative chemotaxis
C6376_RS01995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6376_RS02015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6376_RS02020	COG0509	glycine decarboxylation via glycine cleavage system
C6376_RS02025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6376_RS02030	COG1760	l-serine dehydratase
C6376_RS02060	COG1376	ErfK ybiS ycfS ynhG family protein
C6376_RS02075	COG1132	(ABC) transporter
C6376_RS02080	COG1132	(ABC) transporter
C6376_RS02085	COG1132	(ABC) transporter
C6376_RS02090	COG1132	(ABC) transporter
C6376_RS02115	COG0714	Associated with various cellular activities
C6376_RS02125	COG0058	SHG alpha-glucan phosphorylase activity
C6376_RS02130	COG0366	Alpha amylase catalytic
C6376_RS02135	COG0366	Alpha amylase catalytic
C6376_RS02145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6376_RS02155	COG3118	belongs to the thioredoxin family
C6376_RS02155	COG0492	ferredoxin-NADP+ reductase activity
C6376_RS02165	COG1522	sequence-specific DNA binding
C6376_RS02175	COG0667	Aldo Keto reductase
C6376_RS02185	COG3290	protein histidine kinase activity
C6376_RS02190	COG4565	transcriptional regulatory protein
C6376_RS02195	COG0205	6-phosphofructokinase activity
C6376_RS02200	COG0280	phosphate acetyltransferase
C6376_RS02200	COG0857	belongs to the CobB CobQ family
C6376_RS02205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6376_RS02240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS02240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS02275	COG2814	Major facilitator Superfamily
C6376_RS02310	COG0183	Belongs to the thiolase family
C6376_RS02315	COG0346	lactoylglutathione lyase activity
C6376_RS02330	COG1131	(ABC) transporter
C6376_RS02365	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C6376_RS02390	COG4585	Histidine kinase
C6376_RS02395	COG2197	response regulator
C6376_RS02410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6376_RS02415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6376_RS02420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6376_RS02425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6376_RS02430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6376_RS02435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6376_RS02440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6376_RS02460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6376_RS02465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6376_RS02475	COG2890	protein-(glutamine-N5) methyltransferase activity
C6376_RS02480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6376_RS02485	COG0254	rRNA binding
C6376_RS02505	COG0083	homoserine kinase activity
C6376_RS02515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C6376_RS02520	COG0460	homoserine dehydrogenase
C6376_RS02525	COG0019	diaminopimelate decarboxylase activity
C6376_RS02530	COG0018	arginyl-trna synthetase
C6376_RS02530	COG0018	arginyl-trna synthetase
C6376_RS02640	COG3654	unkown
C6376_RS02685	COG2197	response regulator
C6376_RS02685	COG3903	Transcriptional regulator
C6376_RS02710	COG1609	Transcriptional regulator
C6376_RS02730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C6376_RS02735	COG3285	dna ligase
C6376_RS02735	COG1793	dna ligase
C6376_RS02755	COG2205	protein histidine kinase activity
C6376_RS02770	COG0768	penicillin binding
C6376_RS02780	COG1309	transcriptional regulator
C6376_RS02790	COG0791	NLP P60 protein
C6376_RS02835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6376_RS02855	COG0745	RESPONSE REGULATOR receiver
C6376_RS02860	COG2205	protein histidine kinase activity
C6376_RS02865	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6376_RS02865	COG0567	Dehydrogenase, E1 component
C6376_RS02935	COG0604	alcohol dehydrogenase
C6376_RS02940	COG0281	malic enzyme
C6376_RS02950	COG0765	amino acid transport
C6376_RS02955	COG1126	abc transporter atp-binding protein
C6376_RS02965	COG1595	DNA-templated transcription, initiation
C6376_RS02985	COG2326	polyphosphate kinase activity
C6376_RS03025	COG0142	geranyltranstransferase activity
C6376_RS03030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6376_RS03035	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C6376_RS03080	COG0363	glucosamine-6-phosphate deaminase activity
C6376_RS03085	COG1472	Belongs to the glycosyl hydrolase 3 family
C6376_RS03090	COG0395	ABC-type sugar transport system, permease component
C6376_RS03095	COG1175	transmembrane transport
C6376_RS03100	COG2182	Extracellular solute-binding protein
C6376_RS03105	COG2188	Transcriptional regulator
C6376_RS03145	COG2124	cytochrome p450
C6376_RS03155	COG0242	peptide deformylase activity
C6376_RS03170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C6376_RS03170	COG2199	diguanylate cyclase activity
C6376_RS03175	COG5662	AntiSigma factor
C6376_RS03180	COG1595	DNA-templated transcription, initiation
C6376_RS03190	COG2135	peptidase activity
C6376_RS03200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6376_RS03210	COG2076	Multidrug Resistance protein
C6376_RS03220	COG0483	inositol monophosphate 1-phosphatase activity
C6376_RS03250	COG1615	UPF0182 protein
C6376_RS03260	COG3480	Lon protease (S16) C-terminal proteolytic domain
C6376_RS03310	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6376_RS03360	COG0210	DNA helicase
C6376_RS03390	COG0596	Alpha beta hydrolase
C6376_RS03455	COG0513	Belongs to the DEAD box helicase family
C6376_RS03465	COG1432	Conserved Protein
C6376_RS03475	COG2095	MarC family integral membrane protein
C6376_RS03490	COG2814	Major facilitator Superfamily
C6376_RS03500	COG0598	Magnesium transport protein CorA
C6376_RS03540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6376_RS03545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6376_RS03555	COG1595	DNA-templated transcription, initiation
C6376_RS03570	COG1024	Enoyl-CoA hydratase
C6376_RS03575	COG0519	Catalyzes the synthesis of GMP from XMP
C6376_RS03585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6376_RS03590	COG1611	Belongs to the LOG family
C6376_RS03595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6376_RS03630	COG2197	response regulator
C6376_RS03635	COG4585	Histidine kinase
C6376_RS03645	COG1131	(ABC) transporter
C6376_RS03660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6376_RS03700	COG4608	Belongs to the ABC transporter superfamily
C6376_RS03705	COG0444	Belongs to the ABC transporter superfamily
C6376_RS03710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6376_RS03715	COG0601	transmembrane transport
C6376_RS03725	COG0346	lactoylglutathione lyase activity
C6376_RS03730	COG4608	Belongs to the ABC transporter superfamily
C6376_RS03740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6376_RS03750	COG4166	transmembrane transport
C6376_RS03755	COG1217	gtp-binding protein TYPA
C6376_RS03775	COG1053	succinate dehydrogenase
C6376_RS03780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6376_RS03830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6376_RS03830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6376_RS03875	COG0202	RNA polymerase activity
C6376_RS03890	COG0596	Alpha beta hydrolase
C6376_RS03905	COG4585	Histidine kinase
C6376_RS03910	COG0577	efflux transmembrane transporter activity
C6376_RS03910	COG1136	(ABC) transporter
C6376_RS03915	COG1136	(ABC) transporter
C6376_RS03915	COG0577	efflux transmembrane transporter activity
C6376_RS03920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6376_RS03925	COG0489	protein tyrosine kinase activity
C6376_RS03955	COG0297	glycogen (starch) synthase activity
C6376_RS03975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6376_RS03980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6376_RS03985	COG1086	Polysaccharide biosynthesis protein
C6376_RS04005	COG4115	mRNA cleavage
C6376_RS04010	COG2161	toxin-antitoxin pair type II binding
C6376_RS04025	COG3118	belongs to the thioredoxin family
C6376_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS04050	COG0583	DNA-binding transcription factor activity
C6376_RS04065	COG0012	GTP binding
C6376_RS04080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6376_RS04085	COG1570	exodeoxyribonuclease VII activity
C6376_RS04090	COG1722	exodeoxyribonuclease VII activity
C6376_RS04095	COG0778	Nitroreductase
C6376_RS04120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C6376_RS04120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C6376_RS04125	COG0114	fumarate hydratase activity
C6376_RS04140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6376_RS04160	COG1136	(ABC) transporter
C6376_RS04190	COG0450	alkyl hydroperoxide reductase
C6376_RS04195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6376_RS04210	COG0741	lytic transglycosylase activity
C6376_RS04215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C6376_RS04220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6376_RS04280	COG2197	response regulator
C6376_RS04315	COG2894	cell division
C6376_RS04355	COG1595	DNA-templated transcription, initiation
C6376_RS04385	COG1414	Transcriptional regulator
C6376_RS04400	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C6376_RS04415	COG0436	Aminotransferase
C6376_RS04455	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C6376_RS04465	COG0477	Major facilitator Superfamily
C6376_RS04470	COG1309	transcriptional regulator
C6376_RS04480	COG1331	Highly conserved protein containing a thioredoxin domain
C6376_RS04495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6376_RS04505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6376_RS04520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6376_RS04525	COG2255	four-way junction helicase activity
C6376_RS04555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS04560	COG1064	alcohol dehydrogenase
C6376_RS04600	COG2986	histidine ammonia-lyase
C6376_RS04610	COG1024	Enoyl-CoA hydratase
C6376_RS04620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C6376_RS04630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6376_RS04645	COG0424	maF-like protein
C6376_RS04655	COG4770	biotin carboxylase activity
C6376_RS04685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6376_RS04695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C6376_RS04700	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS04705	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS04720	COG1595	DNA-templated transcription, initiation
C6376_RS04725	COG0745	RESPONSE REGULATOR receiver
C6376_RS04730	COG2205	protein histidine kinase activity
C6376_RS04755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6376_RS04765	COG0583	DNA-binding transcription factor activity
C6376_RS04770	COG2814	Major facilitator Superfamily
C6376_RS04805	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6376_RS04810	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6376_RS04815	COG3845	ABC transporter
C6376_RS04820	COG1744	ABC transporter substrate-binding protein PnrA-like
C6376_RS04825	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6376_RS04825	COG1473	amidohydrolase
C6376_RS04840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS04840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS04850	COG1595	DNA-templated transcription, initiation
C6376_RS04865	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C6376_RS04875	COG2009	succinate dehydrogenase
C6376_RS04885	COG1053	succinate dehydrogenase
C6376_RS04915	COG1309	transcriptional regulator
C6376_RS04920	COG2409	Drug exporters of the RND superfamily
C6376_RS04925	COG0745	RESPONSE REGULATOR receiver
C6376_RS04930	COG2205	protein histidine kinase activity
C6376_RS04935	COG1408	metallophosphoesterase
C6376_RS04945	COG1686	Belongs to the peptidase S11 family
C6376_RS04950	COG1295	ribonuclease BN
C6376_RS04965	COG0180	Tryptophanyl-tRNA synthetase
C6376_RS04970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6376_RS04975	COG0754	glutathionylspermidine amidase activity
C6376_RS04990	COG3224	Antibiotic biosynthesis monooxygenase
C6376_RS04995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6376_RS04995	COG0512	Glutamine amidotransferase of anthranilate synthase
C6376_RS05000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6376_RS05020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6376_RS05035	COG4176	ABC-type proline glycine betaine transport system permease component
C6376_RS05040	COG4175	Glycine betaine
C6376_RS05040	COG0517	IMP dehydrogenase activity
C6376_RS05050	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS05065	COG0039	L-malate dehydrogenase activity
C6376_RS05080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6376_RS05100	COG0138	bifunctional purine biosynthesis protein purh
C6376_RS05130	COG0045	succinate-CoA ligase (ADP-forming) activity
C6376_RS05140	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C6376_RS05150	COG0714	Associated with various cellular activities
C6376_RS05165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS05165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS05185	COG0791	NLP P60 protein
C6376_RS05210	COG2197	response regulator
C6376_RS05260	COG0519	Catalyzes the synthesis of GMP from XMP
C6376_RS05260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6376_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS05285	COG0515	serine threonine protein kinase
C6376_RS05295	COG0515	serine threonine protein kinase
C6376_RS05300	COG0515	serine threonine protein kinase
C6376_RS05305	COG2815	serine threonine protein kinase
C6376_RS05305	COG0515	serine threonine protein kinase
C6376_RS05320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6376_RS05330	COG0516	GMP reductase activity
C6376_RS05340	COG1595	DNA-templated transcription, initiation
C6376_RS05355	COG0583	DNA-binding transcription factor activity
C6376_RS05365	COG4221	oxidoreductase activity
C6376_RS05445	COG0459	protein refolding
C6376_RS05450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6376_RS05455	COG0726	polysaccharide deacetylase
C6376_RS05470	COG4941	Belongs to the sigma-70 factor family
C6376_RS05480	COG1316	TRANSCRIPTIONal
C6376_RS05495	COG1472	Belongs to the glycosyl hydrolase 3 family
C6376_RS05510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6376_RS05530	COG0802	atpase or kinase
C6376_RS05540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6376_RS05545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6376_RS05545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6376_RS05550	COG0736	holo-[acyl-carrier-protein] synthase activity
C6376_RS05565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6376_RS05570	COG1072	(Pantothenic acid kinase))
C6376_RS05580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6376_RS05585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6376_RS05590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6376_RS05600	COG0101	tRNA pseudouridine synthase activity
C6376_RS05605	COG0203	ribosomal protein L17
C6376_RS05610	COG0202	RNA polymerase activity
C6376_RS05615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6376_RS05620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6376_RS05625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6376_RS05630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6376_RS05640	COG0563	adenylate kinase activity
C6376_RS05650	COG0200	Binds to the 23S rRNA
C6376_RS05655	COG1841	ribosomal large subunit assembly
C6376_RS05660	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6376_RS05665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6376_RS05670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6376_RS05675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6376_RS05685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6376_RS05690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6376_RS05695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6376_RS05700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6376_RS05705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6376_RS05710	COG0255	Belongs to the universal ribosomal protein uL29 family
C6376_RS05715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6376_RS05720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6376_RS05725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6376_RS05730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6376_RS05735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6376_RS05740	COG0089	rRNA binding
C6376_RS05745	COG0088	Forms part of the polypeptide exit tunnel
C6376_RS05750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6376_RS05755	COG0051	transcription antitermination factor activity, RNA binding
C6376_RS05780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6376_RS05785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6376_RS05790	COG0049	tRNA binding
C6376_RS05795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6376_RS05805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6376_RS05810	COG0085	RNA polymerase activity
C6376_RS05820	COG0222	ribosome binding
C6376_RS05825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6376_RS05840	COG0081	regulation of translation
C6376_RS05845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6376_RS05865	COG0436	Aminotransferase
C6376_RS05870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6376_RS05875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6376_RS05885	COG2030	dehydratase
C6376_RS05890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6376_RS05910	COG0702	epimerase
C6376_RS06000	COG1666	GTP binding
C6376_RS06005	COG2261	transglycosylase associated protein
C6376_RS06010	COG3304	Inner membrane component domain
C6376_RS06015	COG0501	Belongs to the peptidase M48B family
C6376_RS06020	COG1007	ATP synthesis coupled electron transport
C6376_RS06030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6376_RS06035	COG0713	ATP synthesis coupled electron transport
C6376_RS06040	COG0839	Belongs to the complex I subunit 6 family
C6376_RS06045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6376_RS06050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C6376_RS06055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6376_RS06060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6376_RS06065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6376_RS06075	COG4585	Histidine kinase
C6376_RS06085	COG0674	pyruvate-flavodoxin oxidoreductase activity
C6376_RS06085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C6376_RS06090	COG1013	pyruvate-flavodoxin oxidoreductase activity
C6376_RS06095	COG1733	regulation of RNA biosynthetic process
C6376_RS06100	COG0702	epimerase
C6376_RS06150	COG1131	(ABC) transporter
C6376_RS06160	COG0142	geranyltranstransferase activity
C6376_RS06170	COG0561	phosphatase activity
C6376_RS06195	COG0514	ATP-dependent DNA helicase (RecQ)
C6376_RS06200	COG1007	ATP synthesis coupled electron transport
C6376_RS06210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6376_RS06215	COG0713	ATP synthesis coupled electron transport
C6376_RS06225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6376_RS06230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C6376_RS06235	COG1034	ATP synthesis coupled electron transport
C6376_RS06240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6376_RS06250	COG0649	NAD binding
C6376_RS06255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6376_RS06260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6376_RS06290	COG2226	methyltransferase
C6376_RS06305	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6376_RS06315	COG0515	serine threonine protein kinase
C6376_RS06315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6376_RS06320	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C6376_RS06325	COG1278	Cold shock
C6376_RS06330	COG2226	methyltransferase
C6376_RS06335	COG1053	succinate dehydrogenase
C6376_RS06340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6376_RS06350	COG0183	Belongs to the thiolase family
C6376_RS06365	COG1309	transcriptional regulator
C6376_RS06380	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6376_RS06390	COG0163	prenyltransferase activity
C6376_RS06395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6376_RS06400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C6376_RS06450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6376_RS06455	COG1333	cytochrome c biogenesis protein
C6376_RS06460	COG0785	Cytochrome C biogenesis protein
C6376_RS06465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6376_RS06475	COG0406	alpha-ribazole phosphatase activity
C6376_RS06480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6376_RS06500	COG1609	Transcriptional regulator
C6376_RS06510	COG1175	transmembrane transport
C6376_RS06515	COG0395	ABC-type sugar transport system, permease component
C6376_RS06545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6376_RS06595	COG1690	Belongs to the RtcB family
C6376_RS06615	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C6376_RS06620	COG0018	arginyl-trna synthetase
C6376_RS06635	COG0113	porphobilinogen synthase activity
C6376_RS06665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C6376_RS06670	COG0732	type I restriction modification DNA specificity domain
C6376_RS06675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C6376_RS06690	COG1648	precorrin-2 dehydrogenase activity
C6376_RS06690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6376_RS06695	COG0181	hydroxymethylbilane synthase activity
C6376_RS06700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6376_RS06705	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C6376_RS06755	COG0123	including yeast histone deacetylase and acetoin utilization protein
C6376_RS06770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6376_RS06795	COG0180	Tryptophanyl-tRNA synthetase
C6376_RS06805	COG1335	isochorismatase
C6376_RS06810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C6376_RS06820	COG0842	Transport permease protein
C6376_RS06820	COG1129	ABC transporter
C6376_RS06835	COG4991	sh3 domain protein
C6376_RS06840	COG0515	serine threonine protein kinase
C6376_RS06840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6376_RS06845	COG0129	dihydroxy-acid dehydratase activity
C6376_RS06850	COG1309	transcriptional regulator
C6376_RS06860	COG0248	Ppx GppA phosphatase
C6376_RS06880	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C6376_RS06890	COG1194	a g-specific adenine glycosylase
C6376_RS06895	COG1595	DNA-templated transcription, initiation
C6376_RS06905	COG0745	RESPONSE REGULATOR receiver
C6376_RS06910	COG2205	protein histidine kinase activity
C6376_RS06915	COG0477	Major facilitator Superfamily
C6376_RS06925	COG0739	heme binding
C6376_RS06955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C6376_RS06975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C6376_RS06985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C6376_RS06990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C6376_RS07010	COG1660	Displays ATPase and GTPase activities
C6376_RS07015	COG2197	response regulator
C6376_RS07030	COG0649	NAD binding
C6376_RS07055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6376_RS07055	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6376_RS07070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6376_RS07085	COG0302	gtp cyclohydrolase
C6376_RS07100	COG0037	tRNA processing
C6376_RS07110	COG2027	D-alanyl-D-alanine carboxypeptidase
C6376_RS07115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6376_RS07125	COG0586	Pfam SNARE associated Golgi protein
C6376_RS07130	COG0393	Putative heavy-metal-binding
C6376_RS07135	COG0789	Transcriptional regulator
C6376_RS07160	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS07180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6376_RS07210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6376_RS07210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6376_RS07215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6376_RS07225	COG0702	epimerase
C6376_RS07250	COG3321	synthase
C6376_RS07250	COG0604	alcohol dehydrogenase
C6376_RS07260	COG3321	synthase
C6376_RS07260	COG0604	alcohol dehydrogenase
C6376_RS07265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6376_RS07270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C6376_RS07290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6376_RS07295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6376_RS07300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6376_RS07305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6376_RS07310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6376_RS07320	COG2130	NADP-dependent
C6376_RS07330	COG1960	acyl-CoA dehydrogenase activity
C6376_RS07335	COG2197	response regulator
C6376_RS07355	COG0477	Major facilitator Superfamily
C6376_RS07370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6376_RS07375	COG1819	glycosyl
C6376_RS07380	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C6376_RS07385	COG2124	cytochrome p450
C6376_RS07390	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS07520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6376_RS07525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6376_RS07530	COG1754	DNA topoisomerase type I activity
C6376_RS07530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6376_RS07550	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C6376_RS07555	COG2172	sigma factor antagonist activity
C6376_RS07560	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS07630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6376_RS07650	COG2267	carboxylic ester hydrolase activity
C6376_RS07660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6376_RS07685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6376_RS07700	COG0251	oxidation-reduction process
C6376_RS07715	COG0003	Pfam Anion-transporting ATPase
C6376_RS07730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6376_RS07740	COG1408	metallophosphoesterase
C6376_RS07830	COG0017	Asparaginyl-tRNA synthetase
C6376_RS07870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS07885	COG3547	Transposase (IS116 IS110 IS902 family)
C6376_RS07930	COG2815	serine threonine protein kinase
C6376_RS07930	COG0515	serine threonine protein kinase
C6376_RS08015	COG0312	modulator of DNA gyrase
C6376_RS08030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6376_RS08045	COG0492	ferredoxin-NADP+ reductase activity
C6376_RS08070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6376_RS08075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6376_RS08090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6376_RS08145	COG0701	Predicted permease
C6376_RS08170	COG1595	DNA-templated transcription, initiation
C6376_RS08185	COG0745	RESPONSE REGULATOR receiver
C6376_RS08190	COG2205	protein histidine kinase activity
C6376_RS08210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6376_RS08215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C6376_RS08235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6376_RS08240	COG1802	Transcriptional regulator
C6376_RS08245	COG0463	Glycosyl transferase, family 2
C6376_RS08260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6376_RS08275	COG1131	(ABC) transporter
C6376_RS08280	COG3559	Exporter of polyketide antibiotics
C6376_RS08290	COG2124	cytochrome p450
C6376_RS08295	COG2197	response regulator
C6376_RS08300	COG4585	Histidine kinase
C6376_RS08310	COG3844	kynureninase activity
C6376_RS08325	COG0477	Major facilitator Superfamily
C6376_RS08330	COG0191	fructose-bisphosphate aldolase activity
C6376_RS08335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6376_RS08350	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C6376_RS08380	COG2161	toxin-antitoxin pair type II binding
C6376_RS08385	COG4115	mRNA cleavage
C6376_RS08395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6376_RS08420	COG3629	intracellular signal transduction
C6376_RS08420	COG3903	Transcriptional regulator
C6376_RS08435	COG2267	carboxylic ester hydrolase activity
C6376_RS08450	COG0542	response to heat
C6376_RS08485	COG4213	ABC transporter substrate-binding protein
C6376_RS08490	COG0789	Transcriptional regulator
C6376_RS08495	COG0484	heat shock protein binding
C6376_RS08500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6376_RS08505	COG0443	Heat shock 70 kDa protein
C6376_RS08510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6376_RS08515	COG0247	lactate metabolic process
C6376_RS08515	COG2181	nitrate reductase activity
C6376_RS08535	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C6376_RS08540	COG0717	Belongs to the dCTP deaminase family
C6376_RS08585	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6376_RS08585	COG1136	(ABC) transporter
C6376_RS08615	COG2319	Wd-40 repeat
C6376_RS08615	COG4249	Peptidase C14 caspase catalytic subunit p20
C6376_RS08695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6376_RS08730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C6376_RS08740	COG1191	sigma factor activity
C6376_RS08745	COG1191	sigma factor activity
C6376_RS08765	COG0477	Major facilitator Superfamily
C6376_RS08770	COG2353	YceI-like domain
C6376_RS08775	COG3467	pyridoxamine 5'-phosphate
C6376_RS08790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C6376_RS08800	COG2205	protein histidine kinase activity
C6376_RS08805	COG0745	RESPONSE REGULATOR receiver
C6376_RS08875	COG1051	belongs to the nudix hydrolase family
C6376_RS08925	COG0583	DNA-binding transcription factor activity
C6376_RS08930	COG0789	Transcriptional regulator
C6376_RS08940	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS08945	COG1595	DNA-templated transcription, initiation
C6376_RS09000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6376_RS09015	COG0653	protein targeting
C6376_RS09035	COG0006	proline dipeptidase activity
C6376_RS09070	COG1999	signal sequence binding
C6376_RS09085	COG2837	iron assimilation
C6376_RS09090	COG0077	Prephenate dehydratase
C6376_RS09095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6376_RS09100	COG0561	phosphatase activity
C6376_RS09140	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C6376_RS09165	COG4152	abc transporter atp-binding protein
C6376_RS09175	COG0515	serine threonine protein kinase
C6376_RS09185	COG1454	alcohol dehydrogenase
C6376_RS09190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6376_RS09195	COG2226	methyltransferase
C6376_RS09225	COG0561	phosphatase activity
C6376_RS09230	COG4988	ABC transporter
C6376_RS09235	COG1294	oxidase, subunit
C6376_RS09240	COG1271	oxidase subunit
C6376_RS09245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6376_RS09250	COG1609	Transcriptional regulator
C6376_RS09255	COG3547	Transposase (IS116 IS110 IS902 family)
C6376_RS09285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C6376_RS09310	COG0662	Cupin 2, conserved barrel domain protein
C6376_RS09315	COG1950	PFAM Membrane protein of
C6376_RS09320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6376_RS09325	COG0626	cystathionine gamma-synthase activity
C6376_RS09370	COG0305	Participates in initiation and elongation during chromosome replication
C6376_RS09375	COG0534	Mate efflux family protein
C6376_RS09380	COG0359	binds to the 23S rRNA
C6376_RS09385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6376_RS09390	COG0629	single-stranded DNA binding
C6376_RS09395	COG0360	Binds together with S18 to 16S ribosomal RNA
C6376_RS09420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6376_RS09430	COG1260	myo-inositol-1-phosphate synthase
C6376_RS09445	COG0617	tRNA 3'-terminal CCA addition
C6376_RS09460	COG2815	serine threonine protein kinase
C6376_RS09460	COG0515	serine threonine protein kinase
C6376_RS09465	COG1595	DNA-templated transcription, initiation
C6376_RS09475	COG0492	ferredoxin-NADP+ reductase activity
C6376_RS09480	COG3118	belongs to the thioredoxin family
C6376_RS09495	COG1192	Involved in chromosome partitioning
C6376_RS09500	COG0357	Ribosomal RNA small subunit methyltransferase G
C6376_RS09510	COG0706	membrane insertase activity
C6376_RS09515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6376_RS09520	COG0594	ribonuclease P activity
C6376_RS09530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6376_RS09540	COG0592	DNA-directed DNA polymerase activity
C6376_RS09545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6376_RS09550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6376_RS09555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C6376_RS09560	COG0187	DNA topoisomerase II activity
C6376_RS09565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6376_RS09580	COG0582	viral genome integration into host DNA
C6376_RS09625	COG1609	Transcriptional regulator
C6376_RS09665	COG1247	-acetyltransferase
C6376_RS09670	COG0640	Transcriptional regulator
C6376_RS09700	COG0515	serine threonine protein kinase
C6376_RS09725	COG0705	Rhomboid family
C6376_RS09740	COG3764	Sortase (surface protein transpeptidase)
C6376_RS09755	COG3764	Sortase (surface protein transpeptidase)
C6376_RS09760	COG3764	Sortase (surface protein transpeptidase)
C6376_RS09765	COG0515	serine threonine protein kinase
C6376_RS09775	COG0768	penicillin binding
C6376_RS09790	COG1716	ATPase activity
C6376_RS09795	COG1716	ATPase activity
C6376_RS09820	COG1960	acyl-CoA dehydrogenase activity
C6376_RS09825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6376_RS09830	COG2151	metal-sulfur cluster biosynthetic enzyme
C6376_RS09835	COG3396	Phenylacetate-CoA oxygenase
C6376_RS09840	COG3460	Phenylacetate-CoA oxygenase
C6376_RS09845	COG3396	Phenylacetate-CoA oxygenase
C6376_RS09870	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6376_RS09875	COG1309	transcriptional regulator
C6376_RS09880	COG1522	sequence-specific DNA binding
C6376_RS09900	COG0746	molybdenum cofactor guanylyltransferase activity
C6376_RS09910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6376_RS09930	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS09930	COG3321	synthase
C6376_RS09930	COG0604	alcohol dehydrogenase
C6376_RS09945	COG0515	serine threonine protein kinase
C6376_RS09950	COG0515	serine threonine protein kinase
C6376_RS09955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C6376_RS09965	COG0022	dehydrogenase e1 component
C6376_RS09970	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6376_RS10015	COG1362	aminopeptidase activity
C6376_RS10020	COG1960	acyl-CoA dehydrogenase activity
C6376_RS10030	COG1741	Belongs to the pirin family
C6376_RS10050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6376_RS10070	COG3866	Pectate lyase
C6376_RS10105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6376_RS10125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6376_RS10170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6376_RS10185	COG0366	Alpha amylase catalytic
C6376_RS10195	COG4122	O-methyltransferase activity
C6376_RS10245	COG1316	TRANSCRIPTIONal
C6376_RS10250	COG4585	Histidine kinase
C6376_RS10260	COG0513	Belongs to the DEAD box helicase family
C6376_RS10265	COG1278	Cold shock
C6376_RS10295	COG0726	polysaccharide deacetylase
C6376_RS10305	COG1595	DNA-templated transcription, initiation
C6376_RS10310	COG1252	NADH dehydrogenase
C6376_RS10330	COG0513	Belongs to the DEAD box helicase family
C6376_RS10335	COG1278	Cold shock
C6376_RS10365	COG1376	ErfK ybiS ycfS ynhG family protein
C6376_RS10380	COG0745	RESPONSE REGULATOR receiver
C6376_RS10385	COG2205	protein histidine kinase activity
C6376_RS10510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6376_RS10535	COG3629	intracellular signal transduction
C6376_RS10535	COG3903	Transcriptional regulator
C6376_RS10615	COG0305	Participates in initiation and elongation during chromosome replication
C6376_RS10655	COG0151	Belongs to the GarS family
C6376_RS10670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6376_RS10680	COG2197	response regulator
C6376_RS10720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6376_RS10725	COG0047	phosphoribosylformylglycinamidine synthase activity
C6376_RS10730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6376_RS10755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6376_RS10765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6376_RS10790	COG1643	Atp-dependent helicase
C6376_RS10825	COG0513	Belongs to the DEAD box helicase family
C6376_RS10870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6376_RS10880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6376_RS10880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6376_RS10895	COG0667	Aldo Keto reductase
C6376_RS10905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6376_RS10910	COG0579	oxidoreductase
C6376_RS10930	COG1470	cell adhesion involved in biofilm formation
C6376_RS10930	COG0366	Alpha amylase catalytic
C6376_RS10940	COG1252	NADH dehydrogenase
C6376_RS10950	COG2226	methyltransferase
C6376_RS11040	COG1196	nuclear chromosome segregation
C6376_RS11040	COG0741	lytic transglycosylase activity
C6376_RS11040	COG0739	heme binding
C6376_RS11045	COG0671	phosphoesterase, PA-phosphatase related
C6376_RS11050	COG0277	FAD linked oxidase domain protein
C6376_RS11065	COG1937	Protein conserved in bacteria
C6376_RS11075	COG0306	phosphate transporter
C6376_RS11080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6376_RS11100	COG0406	alpha-ribazole phosphatase activity
C6376_RS11100	COG0494	nUDIX hydrolase
C6376_RS11110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6376_RS11125	COG1131	(ABC) transporter
C6376_RS11140	COG0456	acetyltransferase
C6376_RS11145	COG0737	Belongs to the 5'-nucleotidase family
C6376_RS11150	COG3866	Pectate lyase
C6376_RS11160	COG0745	RESPONSE REGULATOR receiver
C6376_RS11170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6376_RS11175	COG1609	Transcriptional regulator
C6376_RS11180	COG0745	RESPONSE REGULATOR receiver
C6376_RS11205	COG2897	thiosulfate sulfurtransferase activity
C6376_RS11245	COG3485	protocatechuate 3,4-dioxygenase
C6376_RS11255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6376_RS11260	COG1490	D-aminoacyl-tRNA deacylase activity
C6376_RS11270	COG4552	Acetyltransferase involved in intracellular survival and related
C6376_RS11285	COG2188	Transcriptional regulator
C6376_RS11375	COG0438	transferase activity, transferring glycosyl groups
C6376_RS11395	COG0588	phosphoglycerate mutase activity
C6376_RS11480	COG5002	protein histidine kinase activity
C6376_RS11500	COG1329	Transcriptional regulator
C6376_RS11505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C6376_RS11510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6376_RS11515	COG0215	cysteine-tRNA ligase activity
C6376_RS11530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C6376_RS11540	COG3842	ATPase activity
C6376_RS11575	COG0494	nUDIX hydrolase
C6376_RS11610	COG3300	MHYT domain
C6376_RS11610	COG5001	Diguanylate cyclase
C6376_RS11645	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C6376_RS11650	COG0463	Glycosyl transferase, family 2
C6376_RS11655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6376_RS11660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C6376_RS11670	COG0459	protein refolding
C6376_RS11695	COG2272	Belongs to the type-B carboxylesterase lipase family
C6376_RS11710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C6376_RS11745	COG3973	AAA domain
C6376_RS11760	COG1061	Type III restriction enzyme res subunit
C6376_RS11795	COG1278	Cold shock
C6376_RS11800	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C6376_RS11805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6376_RS11815	COG2814	Major facilitator Superfamily
C6376_RS11850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C6376_RS11860	COG2252	PERMEase
C6376_RS11890	COG0667	Aldo Keto reductase
C6376_RS11910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C6376_RS11915	COG0596	Alpha beta hydrolase
C6376_RS11920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6376_RS11925	COG0277	FAD linked oxidase domain protein
C6376_RS11925	COG0247	lactate metabolic process
C6376_RS11930	COG0515	serine threonine protein kinase
C6376_RS11940	COG5006	permease, DMT superfamily
C6376_RS11960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6376_RS11975	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS11995	COG0259	pyridoxamine-phosphate oxidase activity
C6376_RS12015	COG4821	SIS domain
C6376_RS12035	COG1131	(ABC) transporter
C6376_RS12080	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS12090	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS12100	COG1960	acyl-CoA dehydrogenase activity
C6376_RS12105	COG1960	acyl-CoA dehydrogenase activity
C6376_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS12135	COG1960	acyl-CoA dehydrogenase activity
C6376_RS12140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C6376_RS12155	COG2814	Major facilitator Superfamily
C6376_RS12170	COG1024	Enoyl-CoA hydratase
C6376_RS12185	COG2072	flavoprotein involved in K transport
C6376_RS12225	COG0259	pyridoxamine-phosphate oxidase activity
C6376_RS12240	COG1960	acyl-CoA dehydrogenase activity
C6376_RS12250	COG1280	lysine exporter protein (LysE YggA)
C6376_RS12255	COG1522	sequence-specific DNA binding
C6376_RS12260	COG1309	transcriptional regulator
C6376_RS12275	COG0515	serine threonine protein kinase
C6376_RS12275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6376_RS12290	COG1024	Enoyl-CoA hydratase
C6376_RS12305	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS12310	COG1396	sequence-specific DNA binding
C6376_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS12365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6376_RS12400	COG1686	Belongs to the peptidase S11 family
C6376_RS12420	COG0386	Belongs to the glutathione peroxidase family
C6376_RS12480	COG0739	heme binding
C6376_RS12575	COG1414	Transcriptional regulator
C6376_RS12595	COG1846	Transcriptional regulator
C6376_RS12600	COG3384	dioxygenase
C6376_RS12605	COG1247	-acetyltransferase
C6376_RS12610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6376_RS12625	COG2378	regulation of single-species biofilm formation
C6376_RS12630	COG0477	Major facilitator Superfamily
C6376_RS12635	COG1349	DNA-binding transcription factor activity
C6376_RS12645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6376_RS12645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6376_RS12665	COG3191	aminopeptidase activity
C6376_RS12680	COG1970	mechanosensitive ion channel activity
C6376_RS12690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6376_RS12715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6376_RS12720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6376_RS12730	COG0315	cyclic pyranopterin monophosphate synthase activity
C6376_RS12735	COG0315	cyclic pyranopterin monophosphate synthase activity
C6376_RS12735	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6376_RS12740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6376_RS12760	COG0708	Exodeoxyribonuclease III
C6376_RS12770	COG2072	flavoprotein involved in K transport
C6376_RS12775	COG2267	carboxylic ester hydrolase activity
C6376_RS12780	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS12790	COG4946	Tricorn protease homolog
C6376_RS12790	COG0793	Belongs to the peptidase S41A family
C6376_RS12800	COG2409	Drug exporters of the RND superfamily
C6376_RS12825	COG1764	response to oxidative stress
C6376_RS12830	COG1846	Transcriptional regulator
C6376_RS12835	COG1122	ATPase activity
C6376_RS12845	COG0310	cobalt ion transport
C6376_RS12855	COG0768	penicillin binding
C6376_RS12860	COG0768	penicillin binding
C6376_RS12880	COG0084	hydrolase, TatD family'
C6376_RS12890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6376_RS12895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6376_RS12905	COG0488	(ABC) transporter
C6376_RS12960	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C6376_RS12970	COG2197	response regulator
C6376_RS12975	COG1846	Transcriptional regulator
C6376_RS12980	COG4106	trans-aconitate 2-methyltransferase activity
C6376_RS12995	COG1309	transcriptional regulator
C6376_RS13005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C6376_RS13015	COG0193	aminoacyl-tRNA hydrolase activity
C6376_RS13020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6376_RS13025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6376_RS13030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6376_RS13045	COG4585	Histidine kinase
C6376_RS13080	COG1136	(ABC) transporter
C6376_RS13085	COG0577	efflux transmembrane transporter activity
C6376_RS13170	COG0148	phosphopyruvate hydratase activity
C6376_RS13190	COG1252	NADH dehydrogenase
C6376_RS13195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6376_RS13200	COG0577	efflux transmembrane transporter activity
C6376_RS13205	COG1136	(ABC) transporter
C6376_RS13205	COG0577	efflux transmembrane transporter activity
C6376_RS13240	COG0183	Belongs to the thiolase family
C6376_RS13245	COG2755	lipolytic protein G-D-S-L family
C6376_RS13295	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6376_RS13300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6376_RS13310	COG1228	amidohydrolase
C6376_RS13320	COG1191	sigma factor activity
C6376_RS13325	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS13360	COG3104	oligopeptide transport
C6376_RS13365	COG0745	RESPONSE REGULATOR receiver
C6376_RS13370	COG2205	protein histidine kinase activity
C6376_RS13410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C6376_RS13430	COG1316	TRANSCRIPTIONal
C6376_RS13440	COG1316	TRANSCRIPTIONal
C6376_RS13445	COG0463	Glycosyl transferase, family 2
C6376_RS13450	COG1316	TRANSCRIPTIONal
C6376_RS13455	COG1316	TRANSCRIPTIONal
C6376_RS13460	COG1316	TRANSCRIPTIONal
C6376_RS13485	COG0778	Nitroreductase
C6376_RS13485	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C6376_RS13490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C6376_RS13530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6376_RS13535	COG2835	tetraacyldisaccharide 4'-kinase activity
C6376_RS13545	COG1482	cell wall glycoprotein biosynthetic process
C6376_RS13555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6376_RS13600	COG0714	Associated with various cellular activities
C6376_RS13635	COG0745	RESPONSE REGULATOR receiver
C6376_RS13640	COG5002	protein histidine kinase activity
C6376_RS13640	COG5000	phosphorelay sensor kinase activity
C6376_RS13645	COG0823	Involved in the tonB-independent uptake of proteins
C6376_RS13660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6376_RS13665	COG2197	response regulator
C6376_RS13670	COG3214	Protein conserved in bacteria
C6376_RS13680	COG0653	protein targeting
C6376_RS13705	COG2902	Dehydrogenase
C6376_RS13710	COG1134	teichoic acid transport
C6376_RS13730	COG1846	Transcriptional regulator
C6376_RS13735	COG1764	response to oxidative stress
C6376_RS13745	COG1216	Glycosyl transferase, family 2
C6376_RS13750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C6376_RS13755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C6376_RS13760	COG0395	ABC-type sugar transport system, permease component
C6376_RS13765	COG1175	transmembrane transport
C6376_RS13775	COG1674	ftsk spoiiie
C6376_RS13780	COG0515	serine threonine protein kinase
C6376_RS13785	COG0515	serine threonine protein kinase
C6376_RS13795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6376_RS13835	COG2884	Cell division ATP-binding protein ftsE
C6376_RS13840	COG2177	Part of the ABC transporter FtsEX involved in
C6376_RS13845	COG0793	Belongs to the peptidase S41A family
C6376_RS13850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6376_RS13880	COG2223	nitrite transmembrane transporter activity
C6376_RS13905	COG3973	AAA domain
C6376_RS13915	COG0776	regulation of translation
C6376_RS13920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6376_RS13925	COG1678	Uncharacterized ACR, COG1678
C6376_RS13935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C6376_RS13955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6376_RS13970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C6376_RS14005	COG4974	Belongs to the 'phage' integrase family
C6376_RS14040	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C6376_RS14050	COG0277	FAD linked oxidase domain protein
C6376_RS14090	COG1113	amino acid transport
C6376_RS14100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6376_RS14110	COG1335	isochorismatase
C6376_RS14140	COG1263	PTS System
C6376_RS14145	COG1263	PTS System
C6376_RS14150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6376_RS14160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6376_RS14170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6376_RS14200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6376_RS14230	COG2733	membrane
C6376_RS14315	COG3764	Sortase (surface protein transpeptidase)
C6376_RS14350	COG4702	Belongs to the UPF0303 family
C6376_RS14355	COG0673	inositol 2-dehydrogenase activity
C6376_RS14410	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS14425	COG1126	abc transporter atp-binding protein
C6376_RS14430	COG0765	amino acid transport
C6376_RS14435	COG0765	amino acid transport
C6376_RS14450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6376_RS14465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6376_RS14515	COG0406	alpha-ribazole phosphatase activity
C6376_RS14530	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C6376_RS14540	COG0745	RESPONSE REGULATOR receiver
C6376_RS14555	COG0395	ABC-type sugar transport system, permease component
C6376_RS14585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C6376_RS14590	COG4977	sequence-specific DNA binding
C6376_RS14600	COG0589	response to stress
C6376_RS14610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6376_RS14635	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C6376_RS14655	COG1960	acyl-CoA dehydrogenase activity
C6376_RS14670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6376_RS14675	COG1309	transcriptional regulator
C6376_RS14700	COG1946	Acyl-CoA thioesterase
C6376_RS14730	COG2356	endonuclease I
C6376_RS14760	COG1472	Belongs to the glycosyl hydrolase 3 family
C6376_RS14765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6376_RS14790	COG0673	inositol 2-dehydrogenase activity
C6376_RS14825	COG1869	D-ribose catabolic process
C6376_RS14830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6376_RS14855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6376_RS14895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6376_RS14905	COG3718	enzyme involved in inositol metabolism
C6376_RS14910	COG3962	Belongs to the TPP enzyme family
C6376_RS14985	COG0438	transferase activity, transferring glycosyl groups
C6376_RS15005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6376_RS15045	COG2304	oxidoreductase activity
C6376_RS15095	COG0629	single-stranded DNA binding
C6376_RS15135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6376_RS15165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6376_RS15180	COG1486	melibiose metabolic process
C6376_RS15185	COG0395	ABC-type sugar transport system, permease component
C6376_RS15190	COG1175	transmembrane transport
C6376_RS15195	COG1653	transport
C6376_RS15200	COG1940	carbohydrate kinase activity
C6376_RS15205	COG0668	transmembrane transport
C6376_RS15215	COG1122	ATPase activity
C6376_RS15255	COG1846	Transcriptional regulator
C6376_RS15260	COG0697	spore germination
C6376_RS15275	COG2337	Toxic component of a toxin-antitoxin (TA) module
C6376_RS15315	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C6376_RS15335	COG1116	anion transmembrane transporter activity
C6376_RS15340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6376_RS15370	COG0698	ribose 5-phosphate isomerase
C6376_RS15380	COG4552	Acetyltransferase involved in intracellular survival and related
C6376_RS15395	COG3594	Acyltransferase
C6376_RS15415	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6376_RS15420	COG0740	serine-type endopeptidase activity
C6376_RS15425	COG0740	serine-type endopeptidase activity
C6376_RS15430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6376_RS15440	COG0525	valine-tRNA ligase activity
C6376_RS15445	COG0285	dihydrofolate synthase activity
C6376_RS15455	COG0105	UTP biosynthetic process
C6376_RS15460	COG1077	Cell shape determining protein MreB Mrl
C6376_RS15475	COG0768	penicillin binding
C6376_RS15480	COG0772	Belongs to the SEDS family
C6376_RS15495	COG2226	methyltransferase
C6376_RS15500	COG0640	Transcriptional regulator
C6376_RS15510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6376_RS15515	COG0457	Tetratricopeptide repeat
C6376_RS15515	COG0463	Glycosyl transferase, family 2
C6376_RS15530	COG1530	ribonuclease E activity
C6376_RS15535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6376_RS15540	COG0673	inositol 2-dehydrogenase activity
C6376_RS15575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6376_RS15580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6376_RS15585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6376_RS15605	COG1216	Glycosyl transferase, family 2
C6376_RS15615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6376_RS15625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6376_RS15645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6376_RS15655	COG0799	negative regulation of ribosome biogenesis
C6376_RS15660	COG0588	phosphoglycerate mutase activity
C6376_RS15695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6376_RS15705	COG0495	leucyl-tRNA aminoacylation
C6376_RS15715	COG1307	EDD domain protein, DegV family
C6376_RS15730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C6376_RS15750	COG0268	Binds directly to 16S ribosomal RNA
C6376_RS15755	COG0481	GTPase activity
C6376_RS15770	COG2837	iron assimilation
C6376_RS15790	COG1420	regulation of RNA biosynthetic process
C6376_RS15795	COG0484	heat shock protein binding
C6376_RS15825	COG0793	Belongs to the peptidase S41A family
C6376_RS15825	COG4946	Tricorn protease homolog
C6376_RS15830	COG0537	adenosine 5'-monophosphoramidase activity
C6376_RS15835	COG1234	tRNA 3'-trailer cleavage
C6376_RS15840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6376_RS15845	COG1414	Transcriptional regulator
C6376_RS15850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6376_RS15855	COG4948	Mandelate Racemase Muconate Lactonizing
C6376_RS15870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6376_RS15880	COG2315	Protein conserved in bacteria
C6376_RS15915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6376_RS15945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6376_RS15955	COG2409	Drug exporters of the RND superfamily
C6376_RS15960	COG4585	Histidine kinase
C6376_RS15965	COG2197	response regulator
C6376_RS15985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6376_RS16000	COG1381	Involved in DNA repair and RecF pathway recombination
C6376_RS16005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6376_RS16020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6376_RS16025	COG1121	(ABC) transporter
C6376_RS16030	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6376_RS16030	COG3443	Belongs to the bacterial solute-binding protein 9 family
C6376_RS16035	COG0423	glycine-tRNA ligase activity
C6376_RS16050	COG0667	Aldo Keto reductase
C6376_RS16070	COG0477	Major facilitator Superfamily
C6376_RS16105	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C6376_RS16115	COG1846	Transcriptional regulator
C6376_RS16115	COG1940	carbohydrate kinase activity
C6376_RS16120	COG0574	Belongs to the PEP-utilizing enzyme family
C6376_RS16120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6376_RS16130	COG1136	(ABC) transporter
C6376_RS16150	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS16170	COG2146	nitrite reductase [NAD(P)H] activity
C6376_RS16170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6376_RS16175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6376_RS16205	COG0477	Major facilitator Superfamily
C6376_RS16215	COG0243	molybdopterin cofactor binding
C6376_RS16235	COG2949	membrane
C6376_RS16245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C6376_RS16255	COG0358	DNA primase activity
C6376_RS16260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6376_RS16275	COG1070	Carbohydrate kinase
C6376_RS16315	COG0583	DNA-binding transcription factor activity
C6376_RS16335	COG2072	flavoprotein involved in K transport
C6376_RS16340	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS16345	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS16355	COG2223	nitrite transmembrane transporter activity
C6376_RS16415	COG1609	Transcriptional regulator
C6376_RS16470	COG1077	Cell shape determining protein MreB Mrl
C6376_RS16485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6376_RS16485	COG0825	malonyl-CoA metabolic process
C6376_RS16490	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS16505	COG1414	Transcriptional regulator
C6376_RS16510	COG3386	PFAM SMP-30 Gluconolaconase
C6376_RS16550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6376_RS16560	COG4214	carbohydrate transport
C6376_RS16565	COG1129	ABC transporter
C6376_RS16595	COG1609	Transcriptional regulator
C6376_RS16600	COG1879	ABC-type sugar transport system periplasmic component
C6376_RS16610	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6376_RS16615	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6376_RS16630	COG2130	NADP-dependent
C6376_RS16665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6376_RS16670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6376_RS16675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6376_RS16700	COG0789	Transcriptional regulator
C6376_RS16705	COG0667	Aldo Keto reductase
C6376_RS16720	COG1309	transcriptional regulator
C6376_RS16725	COG0477	Major facilitator Superfamily
C6376_RS16735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6376_RS16740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C6376_RS16790	COG1358	cellular component organization or biogenesis
C6376_RS16805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6376_RS16845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS16850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C6376_RS16865	COG2259	Doxx family
C6376_RS16885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6376_RS16925	COG4122	O-methyltransferase activity
C6376_RS16965	COG0183	Belongs to the thiolase family
C6376_RS16970	COG2124	cytochrome p450
C6376_RS16975	COG3619	membrane
C6376_RS16990	COG3845	ABC transporter
C6376_RS17025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6376_RS17045	COG1309	transcriptional regulator
C6376_RS17050	COG0438	transferase activity, transferring glycosyl groups
C6376_RS17070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6376_RS17080	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6376_RS17080	COG2247	cell wall binding repeat
C6376_RS17095	COG0477	Major facilitator Superfamily
C6376_RS17110	COG2197	response regulator
C6376_RS17115	COG4585	Histidine kinase
C6376_RS17120	COG2030	dehydratase
C6376_RS17140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C6376_RS17160	COG3022	response to hydroperoxide
C6376_RS17230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS17240	COG0515	serine threonine protein kinase
C6376_RS17295	COG0174	glutamine synthetase
C6376_RS17310	COG4106	trans-aconitate 2-methyltransferase activity
C6376_RS17415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6376_RS17625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6376_RS17660	COG1061	Type III restriction enzyme res subunit
C6376_RS17670	COG4974	Belongs to the 'phage' integrase family
C6376_RS17725	COG1113	amino acid transport
C6376_RS17760	COG2259	Doxx family
C6376_RS17770	COG1686	Belongs to the peptidase S11 family
C6376_RS17785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS17790	COG2814	Major facilitator Superfamily
C6376_RS17815	COG0672	)-iron permease
C6376_RS17820	COG2837	iron assimilation
C6376_RS17875	COG1994	Peptidase M50
C6376_RS17895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C6376_RS17900	COG0477	Major facilitator Superfamily
C6376_RS17915	COG2814	Major facilitator Superfamily
C6376_RS17920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C6376_RS17920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6376_RS17940	COG1959	2 iron, 2 sulfur cluster binding
C6376_RS17945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6376_RS17945	COG1017	nitric oxide dioxygenase activity
C6376_RS17950	COG0174	glutamine synthetase
C6376_RS17960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6376_RS17970	COG1609	Transcriptional regulator
C6376_RS17975	COG2182	Extracellular solute-binding protein
C6376_RS17980	COG1175	transmembrane transport
C6376_RS17985	COG3833	ABC-type maltose transport systems, permease component
C6376_RS17990	COG0366	Alpha amylase catalytic
C6376_RS18030	COG2197	response regulator
C6376_RS18045	COG0745	RESPONSE REGULATOR receiver
C6376_RS18090	COG0501	Belongs to the peptidase M48B family
C6376_RS18105	COG0174	glutamine synthetase
C6376_RS18125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6376_RS18130	COG0321	lipoyl(octanoyl) transferase activity
C6376_RS18140	COG3976	FMN-binding domain protein
C6376_RS18140	COG0431	NADPH-dependent FMN reductase
C6376_RS18140	COG1053	succinate dehydrogenase
C6376_RS18150	COG0456	acetyltransferase
C6376_RS18180	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C6376_RS18190	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6376_RS18195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6376_RS18200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6376_RS18205	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C6376_RS18220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6376_RS18220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6376_RS18225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6376_RS18270	COG2197	response regulator
C6376_RS18275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6376_RS18275	COG0515	serine threonine protein kinase
C6376_RS18280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C6376_RS18300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6376_RS18310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6376_RS18315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6376_RS18325	COG1376	ErfK ybiS ycfS ynhG family protein
C6376_RS18335	COG1845	cytochrome c oxidase, subunit III
C6376_RS18340	COG2010	Cytochrome c
C6376_RS18345	COG0723	plastoquinol--plastocyanin reductase activity
C6376_RS18350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6376_RS18355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6376_RS18360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6376_RS18405	COG0438	transferase activity, transferring glycosyl groups
C6376_RS18415	COG1022	Amp-dependent synthetase and ligase
C6376_RS18430	COG0003	Pfam Anion-transporting ATPase
C6376_RS18440	COG1940	carbohydrate kinase activity
C6376_RS18475	COG0205	6-phosphofructokinase activity
C6376_RS18490	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6376_RS18495	COG0243	molybdopterin cofactor binding
C6376_RS18500	COG2193	ferroxidase activity
C6376_RS18505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6376_RS18510	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C6376_RS18515	COG0515	serine threonine protein kinase
C6376_RS18515	COG2815	serine threonine protein kinase
C6376_RS18520	COG2022	thiamine diphosphate biosynthetic process
C6376_RS18530	COG2022	thiamine diphosphate biosynthetic process
C6376_RS18530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6376_RS18550	COG0352	thiamine-phosphate diphosphorylase activity
C6376_RS18575	COG1309	transcriptional regulator
C6376_RS18585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C6376_RS18615	COG0714	Associated with various cellular activities
C6376_RS18625	COG0275	rRNA processing
C6376_RS18640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6376_RS18650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6376_RS18655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6376_RS18665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6376_RS18670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C6376_RS18675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6376_RS18680	COG1496	oxidoreductase activity
C6376_RS18690	COG1799	cell septum assembly
C6376_RS18700	COG3599	regulation of cell shape
C6376_RS18705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6376_RS18720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6376_RS18730	COG2153	protein acetylation
C6376_RS18770	COG0587	DNA-directed DNA polymerase activity
C6376_RS18775	COG1432	Conserved Protein
C6376_RS18795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6376_RS18815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6376_RS18820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6376_RS18825	COG0131	Imidazoleglycerol-phosphate dehydratase
C6376_RS18830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6376_RS18835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6376_RS18840	COG0251	oxidation-reduction process
C6376_RS18845	COG0107	imidazoleglycerol-phosphate synthase activity
C6376_RS18865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6376_RS18890	COG0134	indole-3-glycerol-phosphate synthase activity
C6376_RS18900	COG0133	tryptophan synthase activity
C6376_RS18905	COG0159	tryptophan synthase activity
C6376_RS18915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6376_RS18925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS18930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6376_RS18960	COG0070	glutamate synthase
C6376_RS18960	COG0069	glutamate synthase activity
C6376_RS18960	COG0067	glutamate synthase
C6376_RS18970	COG2304	oxidoreductase activity
C6376_RS18975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6376_RS18995	COG1960	acyl-CoA dehydrogenase activity
C6376_RS19000	COG1960	acyl-CoA dehydrogenase activity
C6376_RS19005	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS19010	COG1309	transcriptional regulator
C6376_RS19015	COG0183	Belongs to the thiolase family
C6376_RS19035	COG1024	Enoyl-CoA hydratase
C6376_RS19045	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS19055	COG1605	Chorismate mutase
C6376_RS19055	COG0287	Prephenate dehydrogenase
C6376_RS19075	COG0737	Belongs to the 5'-nucleotidase family
C6376_RS19110	COG0411	ABC transporter
C6376_RS19130	COG2050	protein possibly involved in aromatic compounds catabolism
C6376_RS19170	COG1643	Atp-dependent helicase
C6376_RS19175	COG2226	methyltransferase
C6376_RS19195	COG0237	dephospho-CoA kinase activity
C6376_RS19210	COG2226	methyltransferase
C6376_RS19220	COG1802	Transcriptional regulator
C6376_RS19225	COG1953	Uracil, thiamine, allantoin
C6376_RS19250	COG1132	(ABC) transporter
C6376_RS19275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6376_RS19305	COG0598	Magnesium transport protein CorA
C6376_RS19310	COG2226	methyltransferase
C6376_RS19320	COG2313	pseudouridylate synthase activity
C6376_RS19330	COG0477	Major facilitator Superfamily
C6376_RS19335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6376_RS19340	COG0584	glycerophosphoryl diester phosphodiesterase
C6376_RS19350	COG0556	nucleotide-excision repair
C6376_RS19375	COG0387	Pfam Sodium calcium exchanger
C6376_RS19380	COG1619	proteins homologs of microcin C7 resistance protein MccF
C6376_RS19385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6376_RS19400	COG2318	DinB family
C6376_RS19415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6376_RS19425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6376_RS19435	COG0322	excinuclease ABC activity
C6376_RS19440	COG1660	Displays ATPase and GTPase activities
C6376_RS19445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C6376_RS19450	COG1481	regulation of sporulation
C6376_RS19460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6376_RS19465	COG0126	phosphoglycerate kinase activity
C6376_RS19470	COG0149	triose-phosphate isomerase activity
C6376_RS19475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6376_RS19485	COG0166	Belongs to the GPI family
C6376_RS19490	COG0363	glucosamine-6-phosphate deaminase activity
C6376_RS19505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6376_RS19515	COG0109	protoheme IX farnesyltransferase activity
C6376_RS19540	COG1131	(ABC) transporter
C6376_RS19550	COG2205	protein histidine kinase activity
C6376_RS19570	COG0745	RESPONSE REGULATOR receiver
C6376_RS19590	COG0719	Fe-S assembly protein
C6376_RS19600	COG0396	ATPase activity
C6376_RS19605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6376_RS19610	COG0822	iron-sulfur transferase activity
C6376_RS19615	COG2151	metal-sulfur cluster biosynthetic enzyme
C6376_RS19625	COG2076	Multidrug Resistance protein
C6376_RS19630	COG3226	Transcriptional regulator
C6376_RS19640	COG2171	N-acyltransferase activity
C6376_RS19660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6376_RS19710	COG1309	transcriptional regulator
C6376_RS19720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6376_RS19725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6376_RS19745	COG1234	tRNA 3'-trailer cleavage
C6376_RS19750	COG1802	Transcriptional regulator
C6376_RS19770	COG0395	ABC-type sugar transport system, permease component
C6376_RS19795	COG4677	pectinesterase activity
C6376_RS19805	COG2755	lipolytic protein G-D-S-L family
C6376_RS19810	COG3866	Pectate lyase
C6376_RS19815	COG4677	pectinesterase activity
C6376_RS19820	COG4677	pectinesterase activity
C6376_RS19840	COG1595	DNA-templated transcription, initiation
C6376_RS19845	COG2252	PERMEase
C6376_RS19850	COG0768	penicillin binding
C6376_RS19860	COG1414	Transcriptional regulator
C6376_RS19885	COG5285	phytanoyl-CoA dioxygenase
C6376_RS19890	COG1917	Cupin 2, conserved barrel domain protein
C6376_RS19895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6376_RS19900	COG0456	acetyltransferase
C6376_RS19905	COG2318	DinB family
C6376_RS19920	COG0765	amino acid transport
C6376_RS19925	COG1126	abc transporter atp-binding protein
C6376_RS19950	COG1797	cobyrinic acid a,c-diamide synthase activity
C6376_RS19955	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C6376_RS19970	COG1492	cobalamin metabolic process
C6376_RS19975	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C6376_RS20010	COG0488	(ABC) transporter
C6376_RS20065	COG3387	PFAM Glycoside hydrolase 15-related
C6376_RS20085	COG1966	Carbon starvation protein
C6376_RS20105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6376_RS20125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS20140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6376_RS20145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6376_RS20165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6376_RS20175	COG0312	modulator of DNA gyrase
C6376_RS20180	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS20210	COG0588	phosphoglycerate mutase activity
C6376_RS20215	COG0560	Phosphoserine phosphatase
C6376_RS20215	COG3830	Belongs to the UPF0237 family
C6376_RS20225	COG1716	ATPase activity
C6376_RS20225	COG0842	Transport permease protein
C6376_RS20225	COG1131	(ABC) transporter
C6376_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS20245	COG4585	Histidine kinase
C6376_RS20250	COG2197	response regulator
C6376_RS20270	COG1119	ATPase activity
C6376_RS20290	COG1881	PFAM PEBP family protein
C6376_RS20300	COG2094	Belongs to the DNA glycosylase MPG family
C6376_RS20355	COG0647	UMP catabolic process
C6376_RS20360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6376_RS20365	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6376_RS20370	COG1120	ATPase activity
C6376_RS20390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6376_RS20395	COG0497	DNA recombination
C6376_RS20400	COG0438	transferase activity, transferring glycosyl groups
C6376_RS20420	COG3387	PFAM Glycoside hydrolase 15-related
C6376_RS20430	COG0504	CTP synthase activity
C6376_RS20435	COG0494	nUDIX hydrolase
C6376_RS20445	COG0686	Belongs to the AlaDH PNT family
C6376_RS20460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C6376_RS20465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6376_RS20470	COG1187	pseudouridine synthase activity
C6376_RS20510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6376_RS20520	COG1160	GTP binding
C6376_RS20535	COG3583	domain protein
C6376_RS20550	COG0671	phosphoesterase, PA-phosphatase related
C6376_RS20560	COG0477	Major facilitator Superfamily
C6376_RS20565	COG1960	acyl-CoA dehydrogenase activity
C6376_RS20570	COG1799	cell septum assembly
C6376_RS20605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6376_RS20610	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS20610	COG2030	dehydratase
C6376_RS20630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6376_RS20630	COG0662	Cupin 2, conserved barrel domain protein
C6376_RS20655	COG2226	methyltransferase
C6376_RS20670	COG1725	Transcriptional regulator
C6376_RS20685	COG2755	lipolytic protein G-D-S-L family
C6376_RS20710	COG1595	DNA-templated transcription, initiation
C6376_RS20735	COG2188	Transcriptional regulator
C6376_RS20740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C6376_RS20750	COG1309	transcriptional regulator
C6376_RS20755	COG0243	molybdopterin cofactor binding
C6376_RS20760	COG2851	Citrate transporter
C6376_RS20790	COG0640	Transcriptional regulator
C6376_RS20800	COG1960	acyl-CoA dehydrogenase activity
C6376_RS20820	COG0789	Transcriptional regulator
C6376_RS20885	COG2149	membrane
C6376_RS20890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C6376_RS20910	COG1063	alcohol dehydrogenase
C6376_RS20915	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS20925	COG3265	gluconokinase activity
C6376_RS20930	COG2186	Transcriptional regulator
C6376_RS20935	COG3012	SEC-C Motif Domain Protein
C6376_RS20940	COG0308	aminopeptidase N
C6376_RS20955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6376_RS20985	COG0667	Aldo Keto reductase
C6376_RS20990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6376_RS21000	COG0598	Magnesium transport protein CorA
C6376_RS21005	COG0406	alpha-ribazole phosphatase activity
C6376_RS21020	COG0215	cysteine-tRNA ligase activity
C6376_RS21030	COG2186	Transcriptional regulator
C6376_RS21035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6376_RS21040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6376_RS21045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6376_RS21050	COG1414	Transcriptional regulator
C6376_RS21055	COG1410	methionine synthase
C6376_RS21055	COG0646	methionine synthase
C6376_RS21060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6376_RS21070	COG0747	negative chemotaxis
C6376_RS21075	COG2197	response regulator
C6376_RS21085	COG1994	Peptidase M50
C6376_RS21085	COG0517	IMP dehydrogenase activity
C6376_RS21110	COG1222	aaa ATPase
C6376_RS21115	COG4122	O-methyltransferase activity
C6376_RS21130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6376_RS21135	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6376_RS21150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C6376_RS21155	COG0545	Peptidyl-prolyl cis-trans isomerase
C6376_RS21185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6376_RS21190	COG0805	protein transport
C6376_RS21225	COG1309	transcriptional regulator
C6376_RS21280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6376_RS21305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6376_RS21310	COG2186	Transcriptional regulator
C6376_RS21315	COG0174	glutamine synthetase
C6376_RS21320	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS21370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6376_RS21375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6376_RS21380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6376_RS21385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6376_RS21390	COG5002	protein histidine kinase activity
C6376_RS21395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6376_RS21400	COG0072	phenylalanine-tRNA ligase activity
C6376_RS21400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6376_RS21430	COG1649	PFAM Uncharacterised BCR, COG1649
C6376_RS21440	COG0697	spore germination
C6376_RS21465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6376_RS21470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6376_RS21475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6376_RS21480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6376_RS21485	COG1438	arginine binding
C6376_RS21500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6376_RS21500	COG1017	nitric oxide dioxygenase activity
C6376_RS21520	COG0165	Argininosuccinate lyase
C6376_RS21535	COG0477	Major facilitator Superfamily
C6376_RS21540	COG0204	Acyl-transferase
C6376_RS21540	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS21575	COG1464	Belongs to the NlpA lipoprotein family
C6376_RS21590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6376_RS21595	COG1648	precorrin-2 dehydrogenase activity
C6376_RS21595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6376_RS21650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6376_RS21695	COG1653	transport
C6376_RS21700	COG1175	transmembrane transport
C6376_RS21705	COG0395	ABC-type sugar transport system, permease component
C6376_RS21735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6376_RS21750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6376_RS21755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6376_RS21775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6376_RS21780	COG1560	Kdo2-lipid A biosynthetic process
C6376_RS21785	COG0438	transferase activity, transferring glycosyl groups
C6376_RS21795	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C6376_RS21800	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C6376_RS21805	COG0217	transcriptional regulatory protein
C6376_RS21810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6376_RS21815	COG0632	four-way junction helicase activity
C6376_RS21820	COG2255	four-way junction helicase activity
C6376_RS21835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6376_RS21840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6376_RS21845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6376_RS21850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6376_RS21855	COG1196	nuclear chromosome segregation
C6376_RS21860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6376_RS21870	COG0124	histidyl-tRNA synthetase
C6376_RS21890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6376_RS21905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6376_RS21910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6376_RS21925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6376_RS21930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6376_RS21935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6376_RS21940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6376_RS21950	COG0006	proline dipeptidase activity
C6376_RS21955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6376_RS21960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6376_RS21970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C6376_RS21975	COG0540	Belongs to the ATCase OTCase family
C6376_RS21980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6376_RS21990	COG0505	Belongs to the CarA family
C6376_RS21995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6376_RS22000	COG0167	dihydroorotate dehydrogenase activity
C6376_RS22005	COG0284	orotidine-5'-phosphate decarboxylase activity
C6376_RS22015	COG0194	GDP metabolic process
C6376_RS22020	COG1758	RNA polymerase activity
C6376_RS22030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6376_RS22045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6376_RS22055	COG0137	argininosuccinate synthase activity
C6376_RS22060	COG2409	Drug exporters of the RND superfamily
C6376_RS22065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6376_RS22070	COG2390	Transcriptional regulator
C6376_RS22090	COG2188	Transcriptional regulator
C6376_RS22100	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6376_RS22110	COG3842	ATPase activity
C6376_RS22125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6376_RS22150	COG2223	nitrite transmembrane transporter activity
C6376_RS22155	COG1940	carbohydrate kinase activity
C6376_RS22155	COG1846	Transcriptional regulator
C6376_RS22160	COG0702	epimerase
C6376_RS22175	COG3201	nicotinamide mononucleotide transporter
C6376_RS22180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6376_RS22180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6376_RS22185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6376_RS22190	COG0140	phosphoribosyl-ATP diphosphatase activity
C6376_RS22195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6376_RS22220	COG0237	dephospho-CoA kinase activity
C6376_RS22260	COG0463	Glycosyl transferase, family 2
C6376_RS22275	COG2270	Major facilitator Superfamily
C6376_RS22315	COG1984	allophanate hydrolase subunit 2
C6376_RS22320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C6376_RS22325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6376_RS22330	COG4336	lyase activity
C6376_RS22335	COG2814	Major facilitator Superfamily
C6376_RS22395	COG2816	NAD+ diphosphatase activity
C6376_RS22400	COG1501	Belongs to the glycosyl hydrolase 31 family
C6376_RS22405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6376_RS22415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6376_RS22445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6376_RS22465	COG1716	ATPase activity
C6376_RS22485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6376_RS22495	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6376_RS22495	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6376_RS22515	COG1175	transmembrane transport
C6376_RS22520	COG0395	ABC-type sugar transport system, permease component
C6376_RS22565	COG0477	Major facilitator Superfamily
C6376_RS22605	COG1695	Transcriptional regulator
C6376_RS22640	COG0697	spore germination
C6376_RS22645	COG0583	DNA-binding transcription factor activity
C6376_RS22690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C6376_RS22705	COG2318	DinB family
C6376_RS22715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C6376_RS22770	COG1968	undecaprenyl-diphosphatase activity
C6376_RS22800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6376_RS22840	COG0110	maltose O-acetyltransferase activity
C6376_RS22865	COG0640	Transcriptional regulator
C6376_RS22875	COG1832	CoA-binding protein
C6376_RS22880	COG0215	cysteine-tRNA ligase activity
C6376_RS22890	COG1739	Uncharacterized protein family UPF0029
C6376_RS22895	COG0420	3'-5' exonuclease activity
C6376_RS22900	COG0419	ATPase involved in DNA repair
C6376_RS22905	COG1522	sequence-specific DNA binding
C6376_RS22925	COG0626	cystathionine gamma-synthase activity
C6376_RS22950	COG2188	Transcriptional regulator
C6376_RS22955	COG1940	carbohydrate kinase activity
C6376_RS22970	COG3663	DNA glycosylase
C6376_RS22975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6376_RS23000	COG0577	efflux transmembrane transporter activity
C6376_RS23000	COG1136	(ABC) transporter
C6376_RS23005	COG0577	efflux transmembrane transporter activity
C6376_RS23005	COG1136	(ABC) transporter
C6376_RS23020	COG2226	methyltransferase
C6376_RS23025	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C6376_RS23035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C6376_RS23040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6376_RS23045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C6376_RS23080	COG0740	serine-type endopeptidase activity
C6376_RS23100	COG0831	urea catabolic process
C6376_RS23105	COG0832	Belongs to the urease beta subunit family
C6376_RS23110	COG0804	urea catabolic process
C6376_RS23115	COG0830	nickel cation binding
C6376_RS23120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C6376_RS23125	COG0829	nickel cation binding
C6376_RS23155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6376_RS23160	COG1834	amidinotransferase
C6376_RS23165	COG1522	sequence-specific DNA binding
C6376_RS23170	COG3279	Response regulator of the LytR AlgR family
C6376_RS23180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6376_RS23185	COG3275	phosphorelay sensor kinase activity
C6376_RS23200	COG0205	6-phosphofructokinase activity
C6376_RS23205	COG3442	glutamine amidotransferase
C6376_RS23215	COG0242	peptide deformylase activity
C6376_RS23225	COG1960	acyl-CoA dehydrogenase activity
C6376_RS23245	COG1793	dna ligase
C6376_RS23260	COG1960	acyl-CoA dehydrogenase activity
C6376_RS23265	COG1960	acyl-CoA dehydrogenase activity
C6376_RS23280	COG1051	belongs to the nudix hydrolase family
C6376_RS23285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6376_RS23335	COG2329	Antibiotic biosynthesis monooxygenase
C6376_RS23340	COG0662	Cupin 2, conserved barrel domain protein
C6376_RS23355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6376_RS23360	COG2867	negative regulation of translational initiation
C6376_RS23385	COG4214	carbohydrate transport
C6376_RS23395	COG4213	ABC transporter substrate-binding protein
C6376_RS23440	COG0596	Alpha beta hydrolase
C6376_RS23455	COG1090	epimerase
C6376_RS23460	COG1231	oxidoreductase activity
C6376_RS23515	COG2409	Drug exporters of the RND superfamily
C6376_RS23525	COG4585	Histidine kinase
C6376_RS23530	COG2197	response regulator
C6376_RS23550	COG3507	Belongs to the glycosyl hydrolase 43 family
C6376_RS23600	COG3345	alpha-galactosidase
C6376_RS23610	COG3693	PFAM glycoside hydrolase, family 10
C6376_RS23625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C6376_RS23640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C6376_RS23660	COG0297	glycogen (starch) synthase activity
C6376_RS23665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C6376_RS23680	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS23715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6376_RS23750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6376_RS23750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6376_RS23755	COG0726	polysaccharide deacetylase
C6376_RS23810	COG1053	succinate dehydrogenase
C6376_RS23815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6376_RS23840	COG3360	Dodecin
C6376_RS23845	COG0076	glutamate decarboxylase activity
C6376_RS23855	COG1522	sequence-specific DNA binding
C6376_RS23865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6376_RS23875	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C6376_RS23880	COG0121	glutamine amidotransferase
C6376_RS23885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6376_RS23905	COG2268	Band 7 protein
C6376_RS23935	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C6376_RS23955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6376_RS23975	COG0477	Major facilitator Superfamily
C6376_RS24010	COG1609	Transcriptional regulator
C6376_RS24025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6376_RS24035	COG0242	peptide deformylase activity
C6376_RS24070	COG3851	Histidine kinase
C6376_RS24075	COG2197	response regulator
C6376_RS24085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6376_RS24100	COG1017	nitric oxide dioxygenase activity
C6376_RS24100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6376_RS24105	COG0745	RESPONSE REGULATOR receiver
C6376_RS24110	COG2205	protein histidine kinase activity
C6376_RS24125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6376_RS24125	COG1024	Enoyl-CoA hydratase
C6376_RS24135	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C6376_RS24165	COG0375	protein maturation
C6376_RS24170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C6376_RS24180	COG0298	carbon dioxide binding
C6376_RS24190	COG0309	Hydrogenase expression formation protein (HypE)
C6376_RS24205	COG0583	DNA-binding transcription factor activity
C6376_RS24210	COG0183	Belongs to the thiolase family
C6376_RS24220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6376_RS24235	COG1309	transcriptional regulator
C6376_RS24265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6376_RS24275	COG0604	alcohol dehydrogenase
C6376_RS24275	COG3321	synthase
C6376_RS24285	COG3321	synthase
C6376_RS24285	COG0604	alcohol dehydrogenase
C6376_RS24290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6376_RS24310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6376_RS24315	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C6376_RS24330	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6376_RS24335	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C6376_RS24340	COG0604	alcohol dehydrogenase
C6376_RS24340	COG3321	synthase
C6376_RS24375	COG2124	cytochrome p450
C6376_RS24380	COG3959	Transketolase, thiamine diphosphate binding domain
C6376_RS24395	COG3629	intracellular signal transduction
C6376_RS24400	COG0702	epimerase
C6376_RS24410	COG1819	glycosyl
C6376_RS24425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6376_RS24450	COG1653	transport
C6376_RS24455	COG1175	transmembrane transport
C6376_RS24460	COG0395	ABC-type sugar transport system, permease component
C6376_RS24475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6376_RS24495	COG1609	Transcriptional regulator
C6376_RS24515	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS24520	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6376_RS24525	COG0022	dehydrogenase e1 component
C6376_RS24530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6376_RS24535	COG0517	IMP dehydrogenase activity
C6376_RS24535	COG0617	tRNA 3'-terminal CCA addition
C6376_RS24535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C6376_RS24540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6376_RS24550	COG3387	PFAM Glycoside hydrolase 15-related
C6376_RS24560	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6376_RS24565	COG1794	racemase activity, acting on amino acids and derivatives
C6376_RS24585	COG0367	asparagine synthase
C6376_RS24590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6376_RS24595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6376_RS24610	COG2192	nodulation
C6376_RS24650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6376_RS24655	COG0717	Belongs to the dCTP deaminase family
C6376_RS24660	COG0717	Belongs to the dCTP deaminase family
C6376_RS24665	COG2124	cytochrome p450
C6376_RS24685	COG4555	ABC transporter
C6376_RS24735	COG0110	maltose O-acetyltransferase activity
C6376_RS24820	COG2197	response regulator
C6376_RS24830	COG4221	oxidoreductase activity
C6376_RS24845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6376_RS24855	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS24860	COG0596	Alpha beta hydrolase
C6376_RS24885	COG1802	Transcriptional regulator
C6376_RS24890	COG3971	2-oxopent-4-enoate hydratase activity
C6376_RS24895	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C6376_RS24900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6376_RS24910	COG1309	transcriptional regulator
C6376_RS24925	COG0346	lactoylglutathione lyase activity
C6376_RS24975	COG1609	Transcriptional regulator
C6376_RS24980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6376_RS24990	COG3718	enzyme involved in inositol metabolism
C6376_RS24995	COG3962	Belongs to the TPP enzyme family
C6376_RS25010	COG0673	inositol 2-dehydrogenase activity
C6376_RS25015	COG1082	Xylose isomerase domain protein TIM barrel
C6376_RS25025	COG3509	depolymerase
C6376_RS25065	COG0789	Transcriptional regulator
C6376_RS25075	COG2409	Drug exporters of the RND superfamily
C6376_RS25080	COG2755	lipolytic protein G-D-S-L family
C6376_RS25085	COG2197	response regulator
C6376_RS25100	COG2301	Belongs to the HpcH HpaI aldolase family
C6376_RS25105	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C6376_RS25130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS25195	COG0542	response to heat
C6376_RS25205	COG0723	plastoquinol--plastocyanin reductase activity
C6376_RS25205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6376_RS25210	COG1556	Lactate utilization protein
C6376_RS25215	COG1139	Iron-sulfur cluster binding protein
C6376_RS25220	COG0247	lactate metabolic process
C6376_RS25225	COG1070	Carbohydrate kinase
C6376_RS25230	COG3347	Dehydrogenase
C6376_RS25230	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS25240	COG1129	ABC transporter
C6376_RS25255	COG1879	ABC-type sugar transport system periplasmic component
C6376_RS25270	COG1609	Transcriptional regulator
C6376_RS25285	COG1357	PFAM Pentapeptide repeats (8 copies)
C6376_RS25295	COG1309	transcriptional regulator
C6376_RS25305	COG2706	6-phosphogluconolactonase activity
C6376_RS25345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6376_RS25345	COG1796	DNA polymerase
C6376_RS25370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6376_RS25385	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS25420	COG0435	Glutathione S-transferase
C6376_RS25460	COG3250	beta-galactosidase activity
C6376_RS25515	COG0248	Ppx GppA phosphatase
C6376_RS25525	COG5265	(ABC) transporter
C6376_RS25580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C6376_RS25605	COG3345	alpha-galactosidase
C6376_RS25615	COG1132	(ABC) transporter
C6376_RS25685	COG1309	transcriptional regulator
C6376_RS25690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6376_RS25730	COG1940	carbohydrate kinase activity
C6376_RS25740	COG1175	transmembrane transport
C6376_RS25745	COG0395	ABC-type sugar transport system, permease component
C6376_RS25805	COG2409	Drug exporters of the RND superfamily
C6376_RS25825	COG0019	diaminopimelate decarboxylase activity
C6376_RS25865	COG0515	serine threonine protein kinase
C6376_RS25890	COG3290	protein histidine kinase activity
C6376_RS25910	COG1335	isochorismatase
C6376_RS25935	COG1597	lipid kinase activity
C6376_RS25965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6376_RS25985	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C6376_RS25990	COG0714	Associated with various cellular activities
C6376_RS26010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6376_RS26040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6376_RS26065	COG0395	ABC-type sugar transport system, permease component
C6376_RS26070	COG4209	transmembrane transport
C6376_RS26075	COG1609	Transcriptional regulator
C6376_RS26150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6376_RS26170	COG1120	ATPase activity
C6376_RS26175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6376_RS26200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6376_RS26240	COG3940	Belongs to the glycosyl hydrolase 43 family
C6376_RS26260	COG1175	transmembrane transport
C6376_RS26265	COG0395	ABC-type sugar transport system, permease component
C6376_RS26285	COG1252	NADH dehydrogenase
C6376_RS26350	COG0243	molybdopterin cofactor binding
C6376_RS26360	COG2890	protein-(glutamine-N5) methyltransferase activity
C6376_RS26370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6376_RS26395	COG0745	RESPONSE REGULATOR receiver
C6376_RS26400	COG2205	protein histidine kinase activity
C6376_RS26420	COG3290	protein histidine kinase activity
C6376_RS26435	COG2160	L-arabinose isomerase activity
C6376_RS26480	COG2308	Evidence 4 Homologs of previously reported genes of
C6376_RS26480	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6376_RS26485	COG0367	asparagine synthase
C6376_RS26495	COG0596	Alpha beta hydrolase
C6376_RS26510	COG0789	Transcriptional regulator
C6376_RS26535	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS26575	COG2326	polyphosphate kinase activity
C6376_RS26640	COG2124	cytochrome p450
C6376_RS26645	COG1742	UPF0060 membrane protein
C6376_RS26650	COG1609	Transcriptional regulator
C6376_RS26720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6376_RS26725	COG1191	sigma factor activity
C6376_RS26845	COG0187	DNA topoisomerase II activity
C6376_RS26865	COG0395	ABC-type sugar transport system, permease component
C6376_RS26880	COG1609	Transcriptional regulator
C6376_RS26890	COG2188	Transcriptional regulator
C6376_RS26895	COG4214	carbohydrate transport
C6376_RS26900	COG1129	ABC transporter
C6376_RS26910	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6376_RS26915	COG4948	Mandelate Racemase Muconate Lactonizing
C6376_RS26920	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS26930	COG3254	rhamnose metabolic process
C6376_RS26990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6376_RS27030	COG1278	Cold shock
C6376_RS27035	COG0069	glutamate synthase activity
C6376_RS27040	COG0028	Belongs to the TPP enzyme family
C6376_RS27045	COG1191	sigma factor activity
C6376_RS27070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6376_RS27105	COG0574	Belongs to the PEP-utilizing enzyme family
C6376_RS27105	COG3848	Pyruvate phosphate dikinase
C6376_RS27140	COG3387	PFAM Glycoside hydrolase 15-related
C6376_RS27145	COG1294	oxidase, subunit
C6376_RS27150	COG1271	oxidase subunit
C6376_RS27170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6376_RS27175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6376_RS27200	COG1309	transcriptional regulator
C6376_RS27205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6376_RS27230	COG1846	Transcriptional regulator
C6376_RS27245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C6376_RS27275	COG2319	Wd-40 repeat
C6376_RS27275	COG4249	Peptidase C14 caspase catalytic subunit p20
C6376_RS27280	COG2207	Transcriptional regulator
C6376_RS27285	COG2223	nitrite transmembrane transporter activity
C6376_RS27300	COG0492	ferredoxin-NADP+ reductase activity
C6376_RS27315	COG3852	Histidine kinase
C6376_RS27325	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS27355	COG3511	phospholipase C
C6376_RS27405	COG3284	Transcriptional regulator
C6376_RS27410	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS27425	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C6376_RS27445	COG1294	oxidase, subunit
C6376_RS27450	COG4716	Myosin-crossreactive antigen
C6376_RS27495	COG1131	(ABC) transporter
C6376_RS27525	COG5640	endopeptidase activity
C6376_RS27530	COG0583	DNA-binding transcription factor activity
C6376_RS27550	COG0577	efflux transmembrane transporter activity
C6376_RS27550	COG1136	(ABC) transporter
C6376_RS27555	COG1136	(ABC) transporter
C6376_RS27555	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6376_RS27625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6376_RS27630	COG4638	Rieske (2fe-2S)
C6376_RS27640	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6376_RS27655	COG0517	IMP dehydrogenase activity
C6376_RS27655	COG4175	Glycine betaine
C6376_RS27660	COG4176	ABC-type proline glycine betaine transport system permease component
C6376_RS27675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6376_RS27695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6376_RS27705	COG4638	Rieske (2fe-2S)
C6376_RS27715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6376_RS27720	COG1760	l-serine dehydratase
C6376_RS27730	COG3547	Transposase (IS116 IS110 IS902 family)
C6376_RS27740	COG2072	flavoprotein involved in K transport
C6376_RS27750	COG1309	transcriptional regulator
C6376_RS27780	COG0395	ABC-type sugar transport system, permease component
C6376_RS27785	COG1175	transmembrane transport
C6376_RS27795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6376_RS27805	COG1609	Transcriptional regulator
C6376_RS27870	COG4941	Belongs to the sigma-70 factor family
C6376_RS27880	COG0531	amino acid
C6376_RS27890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6376_RS27895	COG0549	Belongs to the carbamate kinase family
C6376_RS27905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6376_RS27935	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS27935	COG1454	alcohol dehydrogenase
C6376_RS27940	COG0516	GMP reductase activity
C6376_RS27940	COG0517	IMP dehydrogenase activity
C6376_RS27945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6376_RS27945	COG0574	Belongs to the PEP-utilizing enzyme family
C6376_RS27965	COG4974	Belongs to the 'phage' integrase family
C6376_RS28105	COG2378	regulation of single-species biofilm formation
C6376_RS28120	COG0477	Major facilitator Superfamily
C6376_RS28205	COG2267	carboxylic ester hydrolase activity
C6376_RS28215	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS28250	COG0275	rRNA processing
C6376_RS28255	COG0438	transferase activity, transferring glycosyl groups
C6376_RS28260	COG1278	Cold shock
C6376_RS28390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6376_RS28405	COG0535	radical SAM domain protein
C6376_RS28500	COG2197	response regulator
C6376_RS28510	COG1131	(ABC) transporter
C6376_RS28530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6376_RS28545	COG1131	(ABC) transporter
C6376_RS28550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C6376_RS28555	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C6376_RS28570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6376_RS28580	COG1132	(ABC) transporter
C6376_RS28600	COG0275	rRNA processing
C6376_RS28605	COG0438	transferase activity, transferring glycosyl groups
C6376_RS28620	COG0577	efflux transmembrane transporter activity
C6376_RS28620	COG1136	(ABC) transporter
C6376_RS28640	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS28690	COG2963	transposase activity
C6376_RS28700	COG1404	Belongs to the peptidase S8 family
C6376_RS28740	COG0657	acetylesterase activity
C6376_RS28755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6376_RS28770	COG1215	transferase activity, transferring glycosyl groups
C6376_RS28780	COG4310	Domain of unknown function (DUF2172)
C6376_RS28795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6376_RS28850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C6376_RS28855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6376_RS28870	COG1799	cell septum assembly
C6376_RS28920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6376_RS28935	COG2235	arginine
C6376_RS28940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6376_RS28950	COG1024	Enoyl-CoA hydratase
C6376_RS29000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS29005	COG1960	acyl-CoA dehydrogenase activity
C6376_RS29010	COG2086	electron transfer activity
C6376_RS29015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6376_RS29025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6376_RS29035	COG0583	DNA-binding transcription factor activity
C6376_RS29040	COG1063	alcohol dehydrogenase
C6376_RS29055	COG0148	phosphopyruvate hydratase activity
C6376_RS29070	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6376_RS29075	COG2271	Major facilitator Superfamily
C6376_RS29080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6376_RS29110	COG0596	Alpha beta hydrolase
C6376_RS29145	COG0577	efflux transmembrane transporter activity
C6376_RS29145	COG1136	(ABC) transporter
C6376_RS29170	COG3250	beta-galactosidase activity
C6376_RS29195	COG3250	beta-galactosidase activity
C6376_RS29205	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS29235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6376_RS29245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6376_RS29255	COG1595	DNA-templated transcription, initiation
C6376_RS29265	COG3458	cephalosporin-C deacetylase activity
C6376_RS29270	COG4209	transmembrane transport
C6376_RS29275	COG0395	ABC-type sugar transport system, permease component
C6376_RS29280	COG1653	transport
C6376_RS29315	COG1940	carbohydrate kinase activity
C6376_RS29320	COG4213	ABC transporter substrate-binding protein
C6376_RS29330	COG4214	carbohydrate transport
C6376_RS29335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6376_RS29340	COG0531	amino acid
C6376_RS29360	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6376_RS29360	COG1024	Enoyl-CoA hydratase
C6376_RS29365	COG0183	Belongs to the thiolase family
C6376_RS29370	COG1609	Transcriptional regulator
C6376_RS29375	COG3250	beta-galactosidase activity
C6376_RS29385	COG1175	transmembrane transport
C6376_RS29390	COG3833	ABC-type maltose transport systems, permease component
C6376_RS29395	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C6376_RS29410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6376_RS29425	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6376_RS29435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C6376_RS29440	COG3253	May function as heme-dependent peroxidase
C6376_RS29455	COG3220	belongs to the UPF0276 family
C6376_RS29465	COG1121	(ABC) transporter
C6376_RS29490	COG0330	HflC and HflK could
C6376_RS29525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6376_RS29530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6376_RS29540	COG2205	protein histidine kinase activity
C6376_RS29545	COG0745	RESPONSE REGULATOR receiver
C6376_RS29575	COG1174	glycine betaine transport
C6376_RS29605	COG2018	Roadblock/LC7 domain
C6376_RS29610	COG5002	protein histidine kinase activity
C6376_RS29650	COG0642	Histidine kinase
C6376_RS29680	COG1404	Belongs to the peptidase S8 family
C6376_RS29685	COG1309	transcriptional regulator
C6376_RS29700	COG0504	CTP synthase activity
C6376_RS29720	COG3173	Aminoglycoside phosphotransferase
C6376_RS29800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C6376_RS29820	COG1116	anion transmembrane transporter activity
C6376_RS29820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6376_RS29845	COG0529	Catalyzes the synthesis of activated sulfate
C6376_RS29850	COG0175	sulfate reduction
C6376_RS29880	COG1960	acyl-CoA dehydrogenase activity
C6376_RS29915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C6376_RS29930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6376_RS29945	COG2040	homocysteine
C6376_RS29965	COG2755	lipolytic protein G-D-S-L family
C6376_RS30005	COG4555	ABC transporter
C6376_RS30015	COG0395	ABC-type sugar transport system, permease component
C6376_RS30020	COG1175	transmembrane transport
C6376_RS30035	COG0277	FAD linked oxidase domain protein
C6376_RS30065	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS30075	COG1162	GTPase activity
C6376_RS30085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6376_RS30145	COG1802	Transcriptional regulator
C6376_RS30175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6376_RS30195	COG0726	polysaccharide deacetylase
C6376_RS30200	COG3940	Belongs to the glycosyl hydrolase 43 family
C6376_RS30205	COG3940	Belongs to the glycosyl hydrolase 43 family
C6376_RS30220	COG1454	alcohol dehydrogenase
C6376_RS30230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6376_RS30250	COG2197	response regulator
C6376_RS30260	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS30300	COG2351	hydroxyisourate hydrolase activity
C6376_RS30335	COG0436	Aminotransferase
C6376_RS30340	COG1733	regulation of RNA biosynthetic process
C6376_RS30375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6376_RS30380	COG0746	molybdenum cofactor guanylyltransferase activity
C6376_RS30390	COG1414	Transcriptional regulator
C6376_RS30395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6376_RS30400	COG4266	Belongs to the allantoicase family
C6376_RS30410	COG0673	inositol 2-dehydrogenase activity
C6376_RS30415	COG2188	Transcriptional regulator
C6376_RS30420	COG1940	carbohydrate kinase activity
C6376_RS30430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6376_RS30450	COG0517	IMP dehydrogenase activity
C6376_RS30450	COG0516	GMP reductase activity
C6376_RS30460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C6376_RS30475	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C6376_RS30480	COG1140	nitrate reductase beta subunit
C6376_RS30510	COG1136	(ABC) transporter
C6376_RS30520	COG3250	beta-galactosidase activity
C6376_RS30605	COG4585	Histidine kinase
C6376_RS30690	COG0038	chloride channel
C6376_RS30700	COG5285	phytanoyl-CoA dioxygenase
C6376_RS30705	COG1917	Cupin 2, conserved barrel domain protein
C6376_RS30710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6376_RS30715	COG0456	acetyltransferase
C6376_RS30765	COG1609	Transcriptional regulator
C6376_RS30810	COG0745	RESPONSE REGULATOR receiver
C6376_RS30815	COG5002	protein histidine kinase activity
C6376_RS30845	COG2255	four-way junction helicase activity
C6376_RS30865	COG2268	Band 7 protein
C6376_RS30900	COG1595	DNA-templated transcription, initiation
C6376_RS30995	COG2124	cytochrome p450
C6376_RS31005	COG2072	flavoprotein involved in K transport
C6376_RS31105	COG0395	ABC-type sugar transport system, permease component
C6376_RS31120	COG1609	Transcriptional regulator
C6376_RS31130	COG4948	Mandelate Racemase Muconate Lactonizing
C6376_RS31135	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS31155	COG1501	Belongs to the glycosyl hydrolase 31 family
C6376_RS31180	COG2186	Transcriptional regulator
C6376_RS31185	COG4948	Mandelate Racemase Muconate Lactonizing
C6376_RS31195	COG1175	transmembrane transport
C6376_RS31200	COG0395	ABC-type sugar transport system, permease component
C6376_RS31205	COG3254	rhamnose metabolic process
C6376_RS31210	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS31265	COG1733	regulation of RNA biosynthetic process
C6376_RS31280	COG1733	regulation of RNA biosynthetic process
C6376_RS31300	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C6376_RS31310	COG1595	DNA-templated transcription, initiation
C6376_RS31320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6376_RS31320	COG1116	anion transmembrane transporter activity
C6376_RS31325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6376_RS31325	COG1116	anion transmembrane transporter activity
C6376_RS31330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6376_RS31335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6376_RS31340	COG0730	response to heat
C6376_RS31355	COG1733	regulation of RNA biosynthetic process
C6376_RS31385	COG0367	asparagine synthase
C6376_RS31390	COG2814	Major facilitator Superfamily
C6376_RS31400	COG1120	ATPase activity
C6376_RS31405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6376_RS31565	COG0515	serine threonine protein kinase
C6376_RS31650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C6376_RS31660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C6376_RS31995	COG0151	Belongs to the GarS family
C6376_RS32185	COG4106	trans-aconitate 2-methyltransferase activity
C6376_RS32350	COG1051	belongs to the nudix hydrolase family
C6376_RS32355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C6376_RS32355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C6376_RS32360	COG0673	inositol 2-dehydrogenase activity
C6376_RS32385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6376_RS32410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6376_RS32420	COG1132	(ABC) transporter
C6376_RS32470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6376_RS32500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6376_RS32520	COG2771	luxR family
C6376_RS32535	COG3328	transposase activity
C6376_RS32545	COG1073	alpha beta
C6376_RS32590	COG1324	tolerance protein
C6376_RS32600	COG0242	peptide deformylase activity
C6376_RS32645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C6376_RS32645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C6376_RS32650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6376_RS32655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C6376_RS32680	COG0494	nUDIX hydrolase
C6376_RS32690	COG0181	hydroxymethylbilane synthase activity
C6376_RS32765	COG0789	Transcriptional regulator
C6376_RS32805	COG0789	Transcriptional regulator
C6376_RS32815	COG2813	Specifically methylates the guanine in position
C6376_RS32830	COG1051	belongs to the nudix hydrolase family
C6376_RS32840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6376_RS32865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6376_RS32870	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C6376_RS32885	COG1126	abc transporter atp-binding protein
C6376_RS32900	COG0405	Gamma-glutamyltransferase
C6376_RS32905	COG0542	response to heat
C6376_RS32930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6376_RS32945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6376_RS32955	COG1953	Uracil, thiamine, allantoin
C6376_RS32970	COG0483	inositol monophosphate 1-phosphatase activity
C6376_RS32980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C6376_RS32990	COG0243	molybdopterin cofactor binding
C6376_RS33025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6376_RS33030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6376_RS33040	COG0494	nUDIX hydrolase
C6376_RS33045	COG1929	Belongs to the glycerate kinase type-1 family
C6376_RS33055	COG0688	phosphatidylethanolamine metabolic process
C6376_RS33060	COG1960	acyl-CoA dehydrogenase activity
C6376_RS33070	COG2301	Belongs to the HpcH HpaI aldolase family
C6376_RS33075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS33075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS33080	COG0604	alcohol dehydrogenase
C6376_RS33090	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6376_RS33105	COG0596	Alpha beta hydrolase
C6376_RS33120	COG2172	sigma factor antagonist activity
C6376_RS33120	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS33120	COG2208	phosphoserine phosphatase activity
C6376_RS33125	COG2226	methyltransferase
C6376_RS33130	COG2362	D-Aminopeptidase
C6376_RS33135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6376_RS33145	COG1619	proteins homologs of microcin C7 resistance protein MccF
C6376_RS33155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6376_RS33180	COG1793	dna ligase
C6376_RS33180	COG3285	dna ligase
C6376_RS33240	COG0488	(ABC) transporter
C6376_RS33250	COG0693	protein deglycase activity
C6376_RS33255	COG2084	Dehydrogenase
C6376_RS33300	COG0028	Belongs to the TPP enzyme family
C6376_RS33375	COG2154	pterin-4-alpha-carbinolamine dehydratase
C6376_RS33380	COG2226	methyltransferase
C6376_RS33385	COG3401	FG-GAP repeat protein
C6376_RS33400	COG4733	cellulase activity
C6376_RS33400	COG5297	Belongs to the glycosyl hydrolase family 6
C6376_RS33410	COG5297	Belongs to the glycosyl hydrolase family 6
C6376_RS33420	COG4221	oxidoreductase activity
C6376_RS33425	COG0656	L-ascorbic acid biosynthetic process
C6376_RS33445	COG1335	isochorismatase
C6376_RS33450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6376_RS33465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6376_RS33510	COG2072	flavoprotein involved in K transport
C6376_RS33520	COG3938	Belongs to the proline racemase family
C6376_RS33525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6376_RS33540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6376_RS33550	COG2080	2 iron, 2 sulfur cluster binding
C6376_RS33555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6376_RS33560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6376_RS33595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6376_RS33635	COG0003	Pfam Anion-transporting ATPase
C6376_RS33645	COG0747	negative chemotaxis
C6376_RS33650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6376_RS33675	COG0297	glycogen (starch) synthase activity
C6376_RS33695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6376_RS33720	COG0477	Major facilitator Superfamily
C6376_RS33740	COG0588	phosphoglycerate mutase activity
C6376_RS33745	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6376_RS33750	COG0166	Belongs to the GPI family
C6376_RS33765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6376_RS33765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6376_RS33805	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS33830	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6376_RS33845	COG1175	transmembrane transport
C6376_RS33855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6376_RS33865	COG1486	melibiose metabolic process
C6376_RS33875	COG3469	chitinase activity
C6376_RS33885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6376_RS33960	COG1024	Enoyl-CoA hydratase
C6376_RS33985	COG1960	acyl-CoA dehydrogenase activity
C6376_RS33990	COG0183	Belongs to the thiolase family
C6376_RS33995	COG1024	Enoyl-CoA hydratase
C6376_RS34000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS34005	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS34010	COG1960	acyl-CoA dehydrogenase activity
C6376_RS34015	COG1960	acyl-CoA dehydrogenase activity
C6376_RS34020	COG1024	Enoyl-CoA hydratase
C6376_RS34025	COG2186	Transcriptional regulator
C6376_RS34030	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS34045	COG1960	acyl-CoA dehydrogenase activity
C6376_RS34050	COG1960	acyl-CoA dehydrogenase activity
C6376_RS34055	COG1024	Enoyl-CoA hydratase
C6376_RS34090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS34145	COG4638	Rieske (2fe-2S)
C6376_RS34170	COG1024	Enoyl-CoA hydratase
C6376_RS34180	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS34190	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS34195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS34195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS34200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS34225	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS34235	COG1946	Acyl-CoA thioesterase
C6376_RS34240	COG1960	acyl-CoA dehydrogenase activity
C6376_RS34245	COG1960	acyl-CoA dehydrogenase activity
C6376_RS34315	COG1175	transmembrane transport
C6376_RS34320	COG0395	ABC-type sugar transport system, permease component
C6376_RS34330	COG3693	PFAM glycoside hydrolase, family 10
C6376_RS34335	COG3345	alpha-galactosidase
C6376_RS34345	COG0517	IMP dehydrogenase activity
C6376_RS34345	COG0516	GMP reductase activity
C6376_RS34350	COG0517	IMP dehydrogenase activity
C6376_RS34350	COG0516	GMP reductase activity
C6376_RS34355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C6376_RS34360	COG0569	domain protein
C6376_RS34395	COG1477	protein flavinylation
C6376_RS34405	COG2205	protein histidine kinase activity
C6376_RS34445	COG3383	formate dehydrogenase (NAD+) activity
C6376_RS34450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6376_RS34460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6376_RS34500	COG0438	transferase activity, transferring glycosyl groups
C6376_RS34525	COG0438	transferase activity, transferring glycosyl groups
C6376_RS34535	COG3387	PFAM Glycoside hydrolase 15-related
C6376_RS34545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6376_RS34580	COG1309	transcriptional regulator
C6376_RS34585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6376_RS34595	COG3485	protocatechuate 3,4-dioxygenase
C6376_RS34600	COG3485	protocatechuate 3,4-dioxygenase
C6376_RS34620	COG1793	dna ligase
C6376_RS34655	COG1834	amidinotransferase
C6376_RS34660	COG0488	(ABC) transporter
C6376_RS34680	COG1515	deoxyribonuclease V activity
C6376_RS34690	COG3268	Saccharopine dehydrogenase
C6376_RS34700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS34705	COG0183	Belongs to the thiolase family
C6376_RS34710	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6376_RS34710	COG1024	Enoyl-CoA hydratase
C6376_RS34725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6376_RS34735	COG2936	dipeptidyl-peptidase activity
C6376_RS34740	COG0488	(ABC) transporter
C6376_RS34745	COG2183	response to ionizing radiation
C6376_RS34750	COG1024	Enoyl-CoA hydratase
C6376_RS34760	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C6376_RS34805	COG1134	teichoic acid transport
C6376_RS34810	COG1562	ergosterol biosynthetic process
C6376_RS34820	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C6376_RS34830	COG1657	PFAM Prenyltransferase squalene oxidase
C6376_RS34845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6376_RS34850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6376_RS34870	COG2365	Tyrosine phosphatase family
C6376_RS34890	COG2755	lipolytic protein G-D-S-L family
C6376_RS34945	COG1063	alcohol dehydrogenase
C6376_RS34950	COG0156	8-amino-7-oxononanoate synthase activity
C6376_RS34955	COG0583	DNA-binding transcription factor activity
C6376_RS35010	COG0561	phosphatase activity
C6376_RS35015	COG2197	response regulator
C6376_RS35040	COG2267	carboxylic ester hydrolase activity
C6376_RS35045	COG0183	Belongs to the thiolase family
C6376_RS35070	COG4948	Mandelate Racemase Muconate Lactonizing
C6376_RS35105	COG3842	ATPase activity
C6376_RS35110	COG1178	ABC-type Fe3 transport system permease component
C6376_RS35115	COG1840	ABC-type Fe3 transport system, periplasmic component
C6376_RS35120	COG0745	RESPONSE REGULATOR receiver
C6376_RS35125	COG5002	protein histidine kinase activity
C6376_RS35135	COG1960	acyl-CoA dehydrogenase activity
C6376_RS35145	COG2188	Transcriptional regulator
C6376_RS35165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS35175	COG0673	inositol 2-dehydrogenase activity
C6376_RS35180	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS35195	COG0673	inositol 2-dehydrogenase activity
C6376_RS35200	COG1609	Transcriptional regulator
C6376_RS35220	COG1819	glycosyl
C6376_RS35225	COG0596	Alpha beta hydrolase
C6376_RS35235	COG3321	synthase
C6376_RS35235	COG0604	alcohol dehydrogenase
C6376_RS35255	COG1309	transcriptional regulator
C6376_RS35260	COG0235	Class ii aldolase
C6376_RS35300	COG2838	Isocitrate dehydrogenase
C6376_RS35310	COG0668	transmembrane transport
C6376_RS35320	COG1132	(ABC) transporter
C6376_RS35325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6376_RS35330	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS35360	COG4689	acetoacetate decarboxylase
C6376_RS35375	COG0174	glutamine synthetase
C6376_RS35400	COG0598	Magnesium transport protein CorA
C6376_RS35440	COG0589	response to stress
C6376_RS35455	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6376_RS35460	COG1063	alcohol dehydrogenase
C6376_RS35495	COG0205	6-phosphofructokinase activity
C6376_RS35560	COG1408	metallophosphoesterase
C6376_RS35565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6376_RS35565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6376_RS35570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6376_RS35580	COG1937	Protein conserved in bacteria
C6376_RS35585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6376_RS35605	COG1653	transport
C6376_RS35610	COG1175	transmembrane transport
C6376_RS35615	COG0395	ABC-type sugar transport system, permease component
C6376_RS35660	COG1733	regulation of RNA biosynthetic process
C6376_RS35670	COG0789	Transcriptional regulator
C6376_RS35695	COG0659	secondary active sulfate transmembrane transporter activity
C6376_RS35705	COG2824	Alkylphosphonate utilization operon protein PhnA
C6376_RS35710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6376_RS35720	COG1918	ferrous iron import across plasma membrane
C6376_RS35720	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C6376_RS35730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C6376_RS35760	COG0535	radical SAM domain protein
C6376_RS35765	COG2132	Multicopper oxidase
C6376_RS35795	COG1140	nitrate reductase beta subunit
C6376_RS35825	COG3794	PFAM blue (type 1) copper domain protein
C6376_RS35840	COG2132	Multicopper oxidase
C6376_RS35855	COG0514	ATP-dependent DNA helicase (RecQ)
C6376_RS35905	COG4566	intracellular signal transduction
C6376_RS35930	COG0673	inositol 2-dehydrogenase activity
C6376_RS35935	COG1653	transport
C6376_RS35940	COG0395	ABC-type sugar transport system, permease component
C6376_RS35945	COG1175	transmembrane transport
C6376_RS35950	COG1609	Transcriptional regulator
C6376_RS35980	COG1609	Transcriptional regulator
C6376_RS35985	COG1609	Transcriptional regulator
C6376_RS35995	COG1733	regulation of RNA biosynthetic process
C6376_RS36050	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
C6376_RS36065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6376_RS36070	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C6376_RS36075	COG3971	2-oxopent-4-enoate hydratase activity
C6376_RS36085	COG1113	amino acid transport
C6376_RS36090	COG3844	kynureninase activity
C6376_RS36105	COG2197	response regulator
C6376_RS36110	COG4585	Histidine kinase
C6376_RS36115	COG1136	(ABC) transporter
C6376_RS36150	COG1024	Enoyl-CoA hydratase
C6376_RS36170	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36175	COG0183	Belongs to the thiolase family
C6376_RS36180	COG1024	Enoyl-CoA hydratase
C6376_RS36185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS36190	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS36195	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36200	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36205	COG1024	Enoyl-CoA hydratase
C6376_RS36215	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS36230	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36235	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36240	COG1024	Enoyl-CoA hydratase
C6376_RS36275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS36330	COG4638	Rieske (2fe-2S)
C6376_RS36340	COG1228	amidohydrolase
C6376_RS36360	COG1024	Enoyl-CoA hydratase
C6376_RS36365	COG1017	nitric oxide dioxygenase activity
C6376_RS36365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6376_RS36370	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS36380	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS36385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS36385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS36390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS36390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6376_RS36395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6376_RS36405	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS36410	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS36420	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36435	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS36455	COG3250	beta-galactosidase activity
C6376_RS36500	COG2755	lipolytic protein G-D-S-L family
C6376_RS36520	COG1946	Acyl-CoA thioesterase
C6376_RS36525	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36530	COG1960	acyl-CoA dehydrogenase activity
C6376_RS36570	COG2197	response regulator
C6376_RS36580	COG2409	Drug exporters of the RND superfamily
C6376_RS36605	COG3250	beta-galactosidase activity
C6376_RS36615	COG0444	Belongs to the ABC transporter superfamily
C6376_RS36650	COG2197	response regulator
C6376_RS36675	COG4566	intracellular signal transduction
C6376_RS36720	COG4638	Rieske (2fe-2S)
C6376_RS36730	COG3384	dioxygenase
C6376_RS36935	COG0714	Associated with various cellular activities
C6376_RS37250	COG0302	gtp cyclohydrolase
C6376_RS37255	COG0602	queuosine metabolic process
C6376_RS37260	COG0720	synthase
C6376_RS37315	COG3387	PFAM Glycoside hydrolase 15-related
C6376_RS37350	COG1324	tolerance protein
C6376_RS37370	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS37380	COG1846	Transcriptional regulator
C6376_RS37380	COG1940	carbohydrate kinase activity
C6376_RS37385	COG1070	Carbohydrate kinase
C6376_RS37405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6376_RS37465	COG2018	Roadblock/LC7 domain
C6376_RS37475	COG1946	Acyl-CoA thioesterase
C6376_RS37490	COG0254	rRNA binding
C6376_RS37500	COG1132	(ABC) transporter
C6376_RS37515	COG1132	(ABC) transporter
C6376_RS37525	COG2072	flavoprotein involved in K transport
C6376_RS37530	COG0432	Pfam Uncharacterised protein family UPF0047
C6376_RS37560	COG1278	Cold shock
C6376_RS37565	COG0513	Belongs to the DEAD box helicase family
C6376_RS37630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6376_RS37630	COG3321	synthase
C6376_RS37635	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS37640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6376_RS37650	COG2318	DinB family
C6376_RS37665	COG0714	Associated with various cellular activities
C6376_RS37680	COG1278	Cold shock
C6376_RS37705	COG2706	6-phosphogluconolactonase activity
C6376_RS37715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C6376_RS37740	COG1960	acyl-CoA dehydrogenase activity
C6376_RS37755	COG3509	depolymerase
C6376_RS37765	COG3973	AAA domain
C6376_RS37790	COG1309	transcriptional regulator
C6376_RS37805	COG0671	phosphoesterase, PA-phosphatase related
C6376_RS37840	COG0584	glycerophosphoryl diester phosphodiesterase
C6376_RS37865	COG0204	Acyl-transferase
C6376_RS37890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6376_RS37935	COG1660	Displays ATPase and GTPase activities
C6376_RS37945	COG0445	tRNA wobble uridine modification
C6376_RS37985	COG0326	Molecular chaperone. Has ATPase activity
C6376_RS38000	COG2813	Specifically methylates the guanine in position
C6376_RS38005	COG1940	carbohydrate kinase activity
C6376_RS38040	COG1349	DNA-binding transcription factor activity
C6376_RS38080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6376_RS38120	COG2197	response regulator
C6376_RS38130	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS38140	COG0300	oxidoreductase activity
C6376_RS38155	COG1309	transcriptional regulator
C6376_RS38165	COG1309	transcriptional regulator
C6376_RS38170	COG3547	Transposase (IS116 IS110 IS902 family)
C6376_RS38205	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS38215	COG1024	Enoyl-CoA hydratase
C6376_RS38215	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6376_RS38235	COG2267	carboxylic ester hydrolase activity
C6376_RS38240	COG1309	transcriptional regulator
C6376_RS38265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6376_RS38270	COG1733	regulation of RNA biosynthetic process
C6376_RS38275	COG2353	YceI-like domain
C6376_RS38280	COG2197	response regulator
C6376_RS38290	COG1129	ABC transporter
C6376_RS38310	COG1846	Transcriptional regulator
C6376_RS38325	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C6376_RS38330	COG2197	response regulator
C6376_RS38335	COG4585	Histidine kinase
C6376_RS38340	COG2409	Drug exporters of the RND superfamily
C6376_RS38350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6376_RS38360	COG1881	PFAM PEBP family protein
C6376_RS38375	COG2080	2 iron, 2 sulfur cluster binding
C6376_RS38380	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6376_RS38385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6376_RS38395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6376_RS38405	COG0300	oxidoreductase activity
C6376_RS38410	COG1309	transcriptional regulator
C6376_RS38415	COG3507	Belongs to the glycosyl hydrolase 43 family
C6376_RS38425	COG2030	dehydratase
C6376_RS38475	COG0395	ABC-type sugar transport system, permease component
C6376_RS38480	COG1175	transmembrane transport
C6376_RS38500	COG0640	Transcriptional regulator
C6376_RS38510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6376_RS38515	COG1993	acr, cog1993
C6376_RS38520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6376_RS38525	COG1968	undecaprenyl-diphosphatase activity
C6376_RS38530	COG2186	Transcriptional regulator
C6376_RS38535	COG1113	amino acid transport
C6376_RS38550	COG2066	Belongs to the glutaminase family
C6376_RS38555	COG1686	Belongs to the peptidase S11 family
C6376_RS38560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C6376_RS38575	COG1695	Transcriptional regulator
C6376_RS38580	COG2226	methyltransferase
C6376_RS38585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS38590	COG3458	cephalosporin-C deacetylase activity
C6376_RS38600	COG1846	Transcriptional regulator
C6376_RS38605	COG2890	protein-(glutamine-N5) methyltransferase activity
C6376_RS38630	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6376_RS38630	COG1902	pentaerythritol trinitrate reductase activity
C6376_RS38660	COG1461	Dihydroxyacetone kinase
C6376_RS38665	COG2376	Dihydroxyacetone kinase
C6376_RS38710	COG0698	ribose 5-phosphate isomerase
C6376_RS38715	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6376_RS38725	COG4191	Histidine kinase
C6376_RS38730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6376_RS38745	COG1960	acyl-CoA dehydrogenase activity
C6376_RS38755	COG5297	Belongs to the glycosyl hydrolase family 6
C6376_RS38755	COG4733	cellulase activity
C6376_RS39285	COG3940	Belongs to the glycosyl hydrolase 43 family
C6376_RS39395	COG1621	beta-fructofuranosidase activity
C6376_RS39420	COG2814	Major facilitator Superfamily
C6376_RS39465	COG2318	DinB family
C6376_RS39500	COG1051	belongs to the nudix hydrolase family
C6376_RS39525	COG2197	response regulator
C6376_RS39530	COG4585	Histidine kinase
C6376_RS39560	COG0596	Alpha beta hydrolase
C6376_RS39595	COG2197	response regulator
C6376_RS39600	COG4585	Histidine kinase
C6376_RS39605	COG3963	phosphatidate phosphatase activity
C6376_RS39620	COG0110	maltose O-acetyltransferase activity
C6376_RS39625	COG1819	glycosyl
C6376_RS39640	COG1129	ABC transporter
C6376_RS39645	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6376_RS39655	COG0673	inositol 2-dehydrogenase activity
C6376_RS39670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6376_RS39800	COG0509	glycine decarboxylation via glycine cleavage system
C6376_RS39865	COG1113	amino acid transport
C6376_RS39880	COG0384	phenazine biosynthesis protein PhzF
C6376_RS39895	COG2084	Dehydrogenase
C6376_RS39920	COG0515	serine threonine protein kinase
C6376_RS40045	COG4585	Histidine kinase
C6376_RS40050	COG2197	response regulator
C6376_RS40055	COG1819	glycosyl
C6376_RS40095	COG0477	Major facilitator Superfamily
C6376_RS40100	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS40150	COG0154	amidase activity
C6376_RS40155	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS40160	COG2409	Drug exporters of the RND superfamily
C6376_RS40225	COG1484	DNA-dependent DNA replication
C6376_RS40285	COG0028	Belongs to the TPP enzyme family
C6376_RS40315	COG1045	serine acetyltransferase
C6376_RS40325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6376_RS40330	COG1733	regulation of RNA biosynthetic process
C6376_RS40345	COG1595	DNA-templated transcription, initiation
C6376_RS40365	COG1940	carbohydrate kinase activity
C6376_RS40370	COG4214	carbohydrate transport
C6376_RS40380	COG4213	ABC transporter substrate-binding protein
C6376_RS40405	COG4251	negative regulation of phosphorylation
C6376_RS40415	COG2197	response regulator
C6376_RS40420	COG4585	Histidine kinase
C6376_RS40465	COG1522	sequence-specific DNA binding
C6376_RS40500	COG1309	transcriptional regulator
C6376_RS40585	COG1309	transcriptional regulator
C6376_RS40605	COG0583	DNA-binding transcription factor activity
C6376_RS40635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6376_RS40635	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C6376_RS40635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6376_RS40635	COG3321	synthase
C6376_RS40645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6376_RS40650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6376_RS40655	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
C6376_RS40670	COG0019	diaminopimelate decarboxylase activity
C6376_RS40675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6376_RS40700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6376_RS40715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6376_RS40750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6376_RS40760	COG0113	porphobilinogen synthase activity
C6376_RS40765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6376_RS40775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6376_RS40780	COG1764	response to oxidative stress
C6376_RS40785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6376_RS40795	COG1609	Transcriptional regulator
C6376_RS40800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6376_RS40800	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS40800	COG3321	synthase
C6376_RS40800	COG4221	oxidoreductase activity
C6376_RS40810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6376_RS40810	COG0300	oxidoreductase activity
C6376_RS40810	COG3321	synthase
C6376_RS40810	COG4221	oxidoreductase activity
C6376_RS40830	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS40830	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS40830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6376_RS40830	COG3321	synthase
C6376_RS40830	COG0300	oxidoreductase activity
C6376_RS40930	COG1136	(ABC) transporter
C6376_RS40935	COG1136	(ABC) transporter
C6376_RS40935	COG0577	efflux transmembrane transporter activity
C6376_RS40940	COG4585	Histidine kinase
C6376_RS40950	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C6376_RS40955	COG1472	Belongs to the glycosyl hydrolase 3 family
C6376_RS40965	COG0395	ABC-type sugar transport system, permease component
C6376_RS41055	COG2188	Transcriptional regulator
C6376_RS41060	COG2814	Major facilitator Superfamily
C6376_RS41090	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS41100	COG1309	transcriptional regulator
C6376_RS41120	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS41130	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS41135	COG1733	regulation of RNA biosynthetic process
C6376_RS41170	COG1309	transcriptional regulator
C6376_RS41175	COG1960	acyl-CoA dehydrogenase activity
C6376_RS41185	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS41200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6376_RS41250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6376_RS41330	COG0419	ATPase involved in DNA repair
C6376_RS41335	COG0419	ATPase involved in DNA repair
C6376_RS41340	COG0420	3'-5' exonuclease activity
C6376_RS41405	COG0305	Participates in initiation and elongation during chromosome replication
C6376_RS41510	COG2070	2-Nitropropane dioxygenase
C6376_RS41525	COG0318	PFAM AMP-dependent synthetase and ligase
C6376_RS41540	COG1024	Enoyl-CoA hydratase
C6376_RS41595	COG0673	inositol 2-dehydrogenase activity
C6376_RS41605	COG2267	carboxylic ester hydrolase activity
C6376_RS41610	COG0069	glutamate synthase activity
C6376_RS41645	COG0702	epimerase
C6376_RS41650	COG1846	Transcriptional regulator
C6376_RS41675	COG0667	Aldo Keto reductase
C6376_RS41680	COG0583	DNA-binding transcription factor activity
C6376_RS41690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6376_RS41695	COG0346	lactoylglutathione lyase activity
C6376_RS41700	COG0667	Aldo Keto reductase
C6376_RS41705	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS41710	COG4941	Belongs to the sigma-70 factor family
C6376_RS41730	COG1716	ATPase activity
C6376_RS41730	COG0842	Transport permease protein
C6376_RS41730	COG1131	(ABC) transporter
C6376_RS41760	COG1191	sigma factor activity
C6376_RS41765	COG1396	sequence-specific DNA binding
C6376_RS41770	COG0740	serine-type endopeptidase activity
C6376_RS41775	COG0740	serine-type endopeptidase activity
C6376_RS41790	COG0328	RNA-DNA hybrid ribonuclease activity
C6376_RS41815	COG0667	Aldo Keto reductase
C6376_RS41830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6376_RS41840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6376_RS41880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6376_RS41900	COG3189	MarR family transcriptional regulator
C6376_RS41920	COG5002	protein histidine kinase activity
C6376_RS42010	COG2172	sigma factor antagonist activity
C6376_RS42015	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS42020	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS42035	COG1366	Belongs to the anti-sigma-factor antagonist family
C6376_RS42045	COG2205	protein histidine kinase activity
C6376_RS42045	COG0784	Response regulator, receiver
C6376_RS42045	COG5002	protein histidine kinase activity
C6376_RS42050	COG1191	sigma factor activity
C6376_RS42075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6376_RS42080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6376_RS42085	COG3281	Trehalose synthase
C6376_RS42090	COG0366	Alpha amylase catalytic
C6376_RS42095	COG0366	Alpha amylase catalytic
C6376_RS42135	COG0181	hydroxymethylbilane synthase activity
C6376_RS42150	COG1793	dna ligase
C6376_RS42155	COG1846	Transcriptional regulator
C6376_RS42200	COG0009	L-threonylcarbamoyladenylate synthase
C6376_RS42210	COG2124	cytochrome p450
C6376_RS42255	COG0657	acetylesterase activity
C6376_RS42260	COG1609	Transcriptional regulator
C6376_RS42335	COG1295	ribonuclease BN
C6376_RS42355	COG0477	Major facilitator Superfamily
C6376_RS42375	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C6376_RS42385	COG1120	ATPase activity
C6376_RS42390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6376_RS42395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6376_RS42410	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C6376_RS42415	COG1132	(ABC) transporter
C6376_RS42420	COG1132	(ABC) transporter
C6376_RS42425	COG2340	Cysteine-rich secretory protein family
C6376_RS42430	COG5297	Belongs to the glycosyl hydrolase family 6
C6376_RS42435	COG4977	sequence-specific DNA binding
C6376_RS42475	COG2409	Drug exporters of the RND superfamily
C6376_RS42480	COG1595	DNA-templated transcription, initiation
C6376_RS42485	COG3708	Transcriptional regulator
C6376_RS42485	COG2207	Transcriptional regulator
C6376_RS42515	COG4214	carbohydrate transport
C6376_RS42525	COG4213	ABC transporter substrate-binding protein
C6376_RS42530	COG1295	ribonuclease BN
C6376_RS42540	COG2326	polyphosphate kinase activity
C6376_RS42580	COG1012	belongs to the aldehyde dehydrogenase family
C6376_RS42585	COG0517	IMP dehydrogenase activity
C6376_RS42585	COG4175	Glycine betaine
C6376_RS42590	COG4176	ABC-type proline glycine betaine transport system permease component
C6376_RS42620	COG0515	serine threonine protein kinase
C6376_RS42640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6376_RS42660	COG0431	NADPH-dependent FMN reductase
C6376_RS42665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6376_RS42680	COG0800	Aldolase
C6376_RS42685	COG1028	Short-chain dehydrogenase reductase Sdr
C6376_RS42690	COG1063	alcohol dehydrogenase
C6376_RS42705	COG4948	Mandelate Racemase Muconate Lactonizing
C6376_RS42710	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6376_RS42715	COG1129	ABC transporter
C6376_RS42735	COG3547	Transposase (IS116 IS110 IS902 family)
C6376_RS42745	COG3408	Glycogen debranching enzyme
C6376_RS42745	COG3119	arylsulfatase activity
C6376_RS42750	COG4977	sequence-specific DNA binding
C6376_RS42785	COG2197	response regulator
C6376_RS42790	COG4585	Histidine kinase
C6376_RS42830	COG0142	geranyltranstransferase activity
C6376_RS42855	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C6376_RS42870	COG2318	DinB family
C6376_RS42910	COG1278	Cold shock
C6376_RS42930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6376_RS42950	COG1846	Transcriptional regulator
C6376_RS42975	COG3547	Transposase (IS116 IS110 IS902 family)
C6376_RS43010	COG0477	Major facilitator Superfamily
C6376_RS43035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6376_RS43035	COG0574	Belongs to the PEP-utilizing enzyme family
C6376_RS43075	COG2318	DinB family
C6376_RS43090	COG3629	intracellular signal transduction
C6376_RS43090	COG3903	Transcriptional regulator
C6376_RS43115	COG0739	heme binding
C6376_RS43120	COG2197	response regulator
C6376_RS43125	COG4585	Histidine kinase
C6376_RS43140	COG2226	methyltransferase
C6376_RS43155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6376_RS43185	COG0741	lytic transglycosylase activity
C6376_RS43185	COG0791	NLP P60 protein
C6376_RS43210	COG3655	Transcriptional regulator
C6376_RS43220	COG0667	Aldo Keto reductase
C6376_RS43305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6376_RS43320	COG0697	spore germination
C6376_RS43340	COG0076	glutamate decarboxylase activity
C6376_RS43365	COG2267	carboxylic ester hydrolase activity
C6376_RS43390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6376_RS43440	COG5520	Belongs to the glycosyl hydrolase 30 family
C6376_RS43450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6376_RS43465	COG4213	ABC transporter substrate-binding protein
C6376_RS43500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6376_RS43515	COG0671	phosphoesterase, PA-phosphatase related
C6376_RS43525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6376_RS43550	COG2226	methyltransferase
C6376_RS43555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6376_RS43565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6376_RS43585	COG1376	ErfK ybiS ycfS ynhG family protein