locus-tag	class	description
F750_RS00070	COG0419	ATPase involved in DNA repair
F750_RS00075	COG0420	3'-5' exonuclease activity
F750_RS00125	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F750_RS00135	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS00140	COG1309	transcriptional regulator
F750_RS00165	COG1695	Transcriptional regulator
F750_RS00170	COG2217	Heavy metal translocating P-type atpase
F750_RS00240	COG3293	Transposase
F750_RS00255	COG1733	regulation of RNA biosynthetic process
F750_RS00275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F750_RS00280	COG2239	Acts as a magnesium transporter
F750_RS00285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F750_RS00290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F750_RS00295	COG0508	dehydrogenase complex catalyzes the overall conversion of
F750_RS00295	COG0022	dehydrogenase e1 component
F750_RS00300	COG0508	dehydrogenase complex catalyzes the overall conversion of
F750_RS00315	COG3383	formate dehydrogenase (NAD+) activity
F750_RS00320	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F750_RS00345	COG0574	Belongs to the PEP-utilizing enzyme family
F750_RS00345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F750_RS00450	COG2267	carboxylic ester hydrolase activity
F750_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS00590	COG1366	Belongs to the anti-sigma-factor antagonist family
F750_RS00595	COG0300	oxidoreductase activity
F750_RS00610	COG1136	(ABC) transporter
F750_RS00610	COG0577	efflux transmembrane transporter activity
F750_RS00615	COG1136	(ABC) transporter
F750_RS00630	COG0745	RESPONSE REGULATOR receiver
F750_RS00635	COG5002	protein histidine kinase activity
F750_RS00640	COG0726	polysaccharide deacetylase
F750_RS00655	COG1175	transmembrane transport
F750_RS00665	COG1472	Belongs to the glycosyl hydrolase 3 family
F750_RS00675	COG0129	dihydroxy-acid dehydratase activity
F750_RS00680	COG2186	Transcriptional regulator
F750_RS00810	COG4608	Belongs to the ABC transporter superfamily
F750_RS00815	COG0444	Belongs to the ABC transporter superfamily
F750_RS00820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS00825	COG0601	transmembrane transport
F750_RS00840	COG0456	acetyltransferase
F750_RS00860	COG2318	DinB family
F750_RS00910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F750_RS00910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F750_RS00915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F750_RS00965	COG0367	asparagine synthase
F750_RS00970	COG2814	Major facilitator Superfamily
F750_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS01015	COG0477	Major facilitator Superfamily
F750_RS01080	COG2080	2 iron, 2 sulfur cluster binding
F750_RS01085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F750_RS01090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F750_RS01160	COG0745	RESPONSE REGULATOR receiver
F750_RS01165	COG2205	protein histidine kinase activity
F750_RS01195	COG2267	carboxylic ester hydrolase activity
F750_RS01210	COG1309	transcriptional regulator
F750_RS01235	COG3293	Transposase
F750_RS01310	COG2124	cytochrome p450
F750_RS01315	COG1024	Enoyl-CoA hydratase
F750_RS01320	COG2175	clavaminate synthase activity
F750_RS01325	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS01325	COG0300	oxidoreductase activity
F750_RS01325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS01325	COG3321	synthase
F750_RS01355	COG1309	transcriptional regulator
F750_RS01370	COG3693	PFAM glycoside hydrolase, family 10
F750_RS01385	COG1278	Cold shock
F750_RS01405	COG3629	intracellular signal transduction
F750_RS01405	COG3903	Transcriptional regulator
F750_RS01425	COG1045	serine acetyltransferase
F750_RS01450	COG0367	asparagine synthase
F750_RS01460	COG1960	acyl-CoA dehydrogenase activity
F750_RS01480	COG0640	Transcriptional regulator
F750_RS01485	COG0798	PFAM Bile acid sodium symporter
F750_RS01490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F750_RS01515	COG0673	inositol 2-dehydrogenase activity
F750_RS01545	COG2226	methyltransferase
F750_RS01555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F750_RS01570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F750_RS01570	COG2010	Cytochrome c
F750_RS01580	COG0148	phosphopyruvate hydratase activity
F750_RS01590	COG0477	Major facilitator Superfamily
F750_RS01595	COG0586	Pfam SNARE associated Golgi protein
F750_RS01620	COG3940	Belongs to the glycosyl hydrolase 43 family
F750_RS01710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F750_RS01715	COG1120	ATPase activity
F750_RS01750	COG1191	sigma factor activity
F750_RS01765	COG2261	transglycosylase associated protein
F750_RS01785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F750_RS01820	COG3511	phospholipase C
F750_RS01845	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F750_RS01860	COG1891	lyase activity
F750_RS01875	COG0300	oxidoreductase activity
F750_RS01880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F750_RS01890	COG4106	trans-aconitate 2-methyltransferase activity
F750_RS01910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F750_RS01915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F750_RS01920	COG1113	amino acid transport
F750_RS01965	COG2259	Doxx family
F750_RS01980	COG4977	sequence-specific DNA binding
F750_RS02000	COG0346	lactoylglutathione lyase activity
F750_RS02010	COG4941	Belongs to the sigma-70 factor family
F750_RS02015	COG3795	YCII-related domain
F750_RS02025	COG2814	Major facilitator Superfamily
F750_RS02035	COG1278	Cold shock
F750_RS02045	COG0584	glycerophosphoryl diester phosphodiesterase
F750_RS02145	COG1349	DNA-binding transcription factor activity
F750_RS02150	COG1105	Belongs to the carbohydrate kinase PfkB family
F750_RS02160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F750_RS02195	COG5297	Belongs to the glycosyl hydrolase family 6
F750_RS02195	COG4733	cellulase activity
F750_RS02200	COG5297	Belongs to the glycosyl hydrolase family 6
F750_RS02215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F750_RS02275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F750_RS02280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F750_RS02305	COG0596	Alpha beta hydrolase
F750_RS02325	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS02330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F750_RS02355	COG2815	serine threonine protein kinase
F750_RS02355	COG0515	serine threonine protein kinase
F750_RS02365	COG2813	Specifically methylates the guanine in position
F750_RS02375	COG2356	endonuclease I
F750_RS02380	COG2066	Belongs to the glutaminase family
F750_RS02380	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
F750_RS02395	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F750_RS02410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F750_RS02415	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F750_RS02420	COG2080	2 iron, 2 sulfur cluster binding
F750_RS02430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS02475	COG2365	Tyrosine phosphatase family
F750_RS02485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F750_RS02505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F750_RS02515	COG0297	glycogen (starch) synthase activity
F750_RS02515	COG0438	transferase activity, transferring glycosyl groups
F750_RS02560	COG2304	oxidoreductase activity
F750_RS02605	COG0745	RESPONSE REGULATOR receiver
F750_RS02610	COG5002	protein histidine kinase activity
F750_RS02620	COG2376	Dihydroxyacetone kinase
F750_RS02625	COG1461	Dihydroxyacetone kinase
F750_RS02645	COG0488	(ABC) transporter
F750_RS02660	COG1191	sigma factor activity
F750_RS02670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F750_RS02725	COG1120	ATPase activity
F750_RS02730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS02750	COG0254	rRNA binding
F750_RS02765	COG1959	2 iron, 2 sulfur cluster binding
F750_RS02765	COG1295	ribonuclease BN
F750_RS02775	COG0366	Alpha amylase catalytic
F750_RS02780	COG0395	ABC-type sugar transport system, permease component
F750_RS02785	COG1175	transmembrane transport
F750_RS02795	COG5297	Belongs to the glycosyl hydrolase family 6
F750_RS02795	COG4733	cellulase activity
F750_RS02805	COG3250	beta-galactosidase activity
F750_RS02815	COG1653	transport
F750_RS02820	COG0395	ABC-type sugar transport system, permease component
F750_RS02830	COG1609	Transcriptional regulator
F750_RS02835	COG1874	Beta-galactosidase
F750_RS02835	COG0366	Alpha amylase catalytic
F750_RS02845	COG1609	Transcriptional regulator
F750_RS02850	COG1172	Belongs to the binding-protein-dependent transport system permease family
F750_RS02860	COG1129	ABC transporter
F750_RS02865	COG1879	ABC-type sugar transport system periplasmic component
F750_RS02885	COG1609	Transcriptional regulator
F750_RS02905	COG3537	Alpha-1,2-mannosidase
F750_RS02910	COG1505	serine-type exopeptidase activity
F750_RS02920	COG3401	FG-GAP repeat protein
F750_RS02945	COG0328	RNA-DNA hybrid ribonuclease activity
F750_RS02950	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS02980	COG1063	alcohol dehydrogenase
F750_RS03000	COG1349	DNA-binding transcription factor activity
F750_RS03015	COG1073	alpha beta
F750_RS03015	COG2226	methyltransferase
F750_RS03020	COG3290	protein histidine kinase activity
F750_RS03025	COG2409	Drug exporters of the RND superfamily
F750_RS03040	COG1755	Isoprenylcysteine carboxyl methyltransferase
F750_RS03055	COG0395	ABC-type sugar transport system, permease component
F750_RS03060	COG1175	transmembrane transport
F750_RS03115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F750_RS03120	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F750_RS03125	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F750_RS03160	COG1132	(ABC) transporter
F750_RS03205	COG0714	Associated with various cellular activities
F750_RS03225	COG4585	Histidine kinase
F750_RS03230	COG2197	response regulator
F750_RS03255	COG3548	integral membrane protein
F750_RS03275	COG0235	Class ii aldolase
F750_RS03280	COG3395	kinase activity
F750_RS03295	COG1349	DNA-binding transcription factor activity
F750_RS03315	COG0494	nUDIX hydrolase
F750_RS03330	COG0488	(ABC) transporter
F750_RS03335	COG0385	Bile acid
F750_RS03355	COG0142	geranyltranstransferase activity
F750_RS03375	COG1175	transmembrane transport
F750_RS03380	COG0395	ABC-type sugar transport system, permease component
F750_RS03405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F750_RS03405	COG2205	protein histidine kinase activity
F750_RS03415	COG2172	sigma factor antagonist activity
F750_RS03420	COG1366	Belongs to the anti-sigma-factor antagonist family
F750_RS03425	COG1366	Belongs to the anti-sigma-factor antagonist family
F750_RS03445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F750_RS03485	COG1349	DNA-binding transcription factor activity
F750_RS03525	COG1940	carbohydrate kinase activity
F750_RS03560	COG0445	tRNA wobble uridine modification
F750_RS03570	COG0494	nUDIX hydrolase
F750_RS03590	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F750_RS03630	COG0584	glycerophosphoryl diester phosphodiesterase
F750_RS03650	COG0671	phosphoesterase, PA-phosphatase related
F750_RS03685	COG1902	pentaerythritol trinitrate reductase activity
F750_RS03695	COG1472	Belongs to the glycosyl hydrolase 3 family
F750_RS03705	COG1175	transmembrane transport
F750_RS03715	COG1609	Transcriptional regulator
F750_RS03720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F750_RS03745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F750_RS03760	COG2706	6-phosphogluconolactonase activity
F750_RS03775	COG1309	transcriptional regulator
F750_RS03780	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS03790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F750_RS03795	COG2815	serine threonine protein kinase
F750_RS03795	COG0515	serine threonine protein kinase
F750_RS03800	COG0667	Aldo Keto reductase
F750_RS03895	COG1349	DNA-binding transcription factor activity
F750_RS03915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F750_RS03920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F750_RS03930	COG0254	rRNA binding
F750_RS03940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F750_RS03950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F750_RS03950	COG1263	PTS System
F750_RS03955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F750_RS03970	COG2186	Transcriptional regulator
F750_RS03975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F750_RS03985	COG4948	Mandelate Racemase Muconate Lactonizing
F750_RS04000	COG0444	Belongs to the ABC transporter superfamily
F750_RS04005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS04010	COG0601	transmembrane transport
F750_RS04015	COG0747	negative chemotaxis
F750_RS04030	COG1917	Cupin 2, conserved barrel domain protein
F750_RS04040	COG0456	acetyltransferase
F750_RS04045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F750_RS04070	COG1309	transcriptional regulator
F750_RS04105	COG0739	heme binding
F750_RS04135	COG1408	metallophosphoesterase
F750_RS04140	COG1132	(ABC) transporter
F750_RS04150	COG0277	FAD linked oxidase domain protein
F750_RS04155	COG1132	(ABC) transporter
F750_RS04160	COG1132	(ABC) transporter
F750_RS04170	COG1793	dna ligase
F750_RS04185	COG1946	Acyl-CoA thioesterase
F750_RS04220	COG0386	Belongs to the glutathione peroxidase family
F750_RS04225	COG1960	acyl-CoA dehydrogenase activity
F750_RS04235	COG0242	peptide deformylase activity
F750_RS04245	COG3442	glutamine amidotransferase
F750_RS04250	COG0205	6-phosphofructokinase activity
F750_RS04280	COG0204	Acyl-transferase
F750_RS04295	COG0829	nickel cation binding
F750_RS04300	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F750_RS04310	COG0804	urea catabolic process
F750_RS04315	COG0832	Belongs to the urease beta subunit family
F750_RS04320	COG0831	urea catabolic process
F750_RS04325	COG1309	transcriptional regulator
F750_RS04340	COG0740	serine-type endopeptidase activity
F750_RS04360	COG0156	8-amino-7-oxononanoate synthase activity
F750_RS04365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F750_RS04370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F750_RS04375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F750_RS04425	COG1595	DNA-templated transcription, initiation
F750_RS04470	COG0517	IMP dehydrogenase activity
F750_RS04470	COG0516	GMP reductase activity
F750_RS04495	COG0589	response to stress
F750_RS04500	COG0516	GMP reductase activity
F750_RS04500	COG0517	IMP dehydrogenase activity
F750_RS04520	COG2239	Acts as a magnesium transporter
F750_RS04530	COG0702	epimerase
F750_RS04550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F750_RS04575	COG4585	Histidine kinase
F750_RS04580	COG2197	response regulator
F750_RS04585	COG1940	carbohydrate kinase activity
F750_RS04590	COG2188	Transcriptional regulator
F750_RS04595	COG1595	DNA-templated transcription, initiation
F750_RS04615	COG0626	cystathionine gamma-synthase activity
F750_RS04640	COG1522	sequence-specific DNA binding
F750_RS04645	COG0419	ATPase involved in DNA repair
F750_RS04650	COG0420	3'-5' exonuclease activity
F750_RS04655	COG1739	Uncharacterized protein family UPF0029
F750_RS04660	COG1832	CoA-binding protein
F750_RS04720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F750_RS04745	COG1968	undecaprenyl-diphosphatase activity
F750_RS04750	COG0243	molybdopterin cofactor binding
F750_RS04760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F750_RS04770	COG2318	DinB family
F750_RS04780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F750_RS04815	COG0640	Transcriptional regulator
F750_RS04830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F750_RS04845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F750_RS04855	COG2124	cytochrome p450
F750_RS04875	COG0697	spore germination
F750_RS04900	COG1695	Transcriptional regulator
F750_RS04930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F750_RS04930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F750_RS04940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F750_RS04960	COG1716	ATPase activity
F750_RS04980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F750_RS05010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F750_RS05020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F750_RS05035	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F750_RS05055	COG2018	Roadblock/LC7 domain
F750_RS05125	COG2364	Membrane
F750_RS05135	COG2270	Major facilitator Superfamily
F750_RS05145	COG3030	protein affecting phage T7 exclusion by the F plasmid
F750_RS05150	COG1216	Glycosyl transferase, family 2
F750_RS05170	COG1960	acyl-CoA dehydrogenase activity
F750_RS05210	COG0783	Belongs to the Dps family
F750_RS05245	COG4555	ABC transporter
F750_RS05320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F750_RS05325	COG0140	phosphoribosyl-ATP diphosphatase activity
F750_RS05330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F750_RS05335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F750_RS05335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F750_RS05340	COG3201	nicotinamide mononucleotide transporter
F750_RS05355	COG1940	carbohydrate kinase activity
F750_RS05355	COG1846	Transcriptional regulator
F750_RS05360	COG0738	Major facilitator superfamily
F750_RS05365	COG2233	PERMEase
F750_RS05375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F750_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS05400	COG2390	Transcriptional regulator
F750_RS05405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F750_RS05410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F750_RS05415	COG4521	taurine ABC transporter
F750_RS05425	COG2175	clavaminate synthase activity
F750_RS05435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F750_RS05450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F750_RS05460	COG1758	RNA polymerase activity
F750_RS05475	COG0284	orotidine-5'-phosphate decarboxylase activity
F750_RS05480	COG0167	dihydroorotate dehydrogenase activity
F750_RS05485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F750_RS05490	COG0505	Belongs to the CarA family
F750_RS05500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F750_RS05505	COG0540	Belongs to the ATCase OTCase family
F750_RS05510	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F750_RS05520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F750_RS05525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F750_RS05530	COG0006	proline dipeptidase activity
F750_RS05540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F750_RS05545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F750_RS05550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F750_RS05565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F750_RS05570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F750_RS05575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F750_RS05595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F750_RS05615	COG0124	histidyl-tRNA synthetase
F750_RS05630	COG1196	nuclear chromosome segregation
F750_RS05635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F750_RS05640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F750_RS05645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F750_RS05650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F750_RS05660	COG2255	four-way junction helicase activity
F750_RS05665	COG0632	four-way junction helicase activity
F750_RS05670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F750_RS05675	COG0217	transcriptional regulatory protein
F750_RS05680	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F750_RS05685	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F750_RS05695	COG0438	transferase activity, transferring glycosyl groups
F750_RS05700	COG1560	Kdo2-lipid A biosynthetic process
F750_RS05705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F750_RS05720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F750_RS05735	COG0667	Aldo Keto reductase
F750_RS05740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
F750_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS05760	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS05805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F750_RS05815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS05815	COG4221	oxidoreductase activity
F750_RS05815	COG0604	alcohol dehydrogenase
F750_RS05815	COG3321	synthase
F750_RS05825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F750_RS05830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F750_RS05845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F750_RS05870	COG0395	ABC-type sugar transport system, permease component
F750_RS05875	COG1175	transmembrane transport
F750_RS05905	COG1609	Transcriptional regulator
F750_RS05920	COG0456	acetyltransferase
F750_RS05920	COG0454	-acetyltransferase
F750_RS05930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F750_RS05990	COG4585	Histidine kinase
F750_RS05995	COG2197	response regulator
F750_RS06005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F750_RS06005	COG1648	precorrin-2 dehydrogenase activity
F750_RS06010	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F750_RS06025	COG1464	Belongs to the NlpA lipoprotein family
F750_RS06030	COG2011	ABC-type metal ion transport system permease component
F750_RS06070	COG0477	Major facilitator Superfamily
F750_RS06090	COG0165	Argininosuccinate lyase
F750_RS06100	COG1438	arginine binding
F750_RS06105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F750_RS06110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F750_RS06115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F750_RS06120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F750_RS06140	COG2197	response regulator
F750_RS06145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F750_RS06160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F750_RS06165	COG0697	spore germination
F750_RS06175	COG1649	PFAM Uncharacterised BCR, COG1649
F750_RS06185	COG1116	anion transmembrane transporter activity
F750_RS06190	COG0494	nUDIX hydrolase
F750_RS06200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F750_RS06200	COG0072	phenylalanine-tRNA ligase activity
F750_RS06205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F750_RS06210	COG5002	protein histidine kinase activity
F750_RS06215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F750_RS06220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F750_RS06225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F750_RS06230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F750_RS06270	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS06275	COG0174	glutamine synthetase
F750_RS06285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F750_RS06305	COG4176	ABC-type proline glycine betaine transport system permease component
F750_RS06310	COG4175	Glycine betaine
F750_RS06310	COG0517	IMP dehydrogenase activity
F750_RS06315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F750_RS06325	COG1595	DNA-templated transcription, initiation
F750_RS06350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F750_RS06355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F750_RS06395	COG0805	protein transport
F750_RS06400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F750_RS06420	COG2378	regulation of single-species biofilm formation
F750_RS06430	COG0545	Peptidyl-prolyl cis-trans isomerase
F750_RS06435	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F750_RS06445	COG1609	Transcriptional regulator
F750_RS06450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F750_RS06455	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F750_RS06465	COG4122	O-methyltransferase activity
F750_RS06470	COG1222	aaa ATPase
F750_RS06490	COG1994	Peptidase M50
F750_RS06490	COG0517	IMP dehydrogenase activity
F750_RS06500	COG2197	response regulator
F750_RS06505	COG4166	transmembrane transport
F750_RS06515	COG0646	methionine synthase
F750_RS06515	COG1410	methionine synthase
F750_RS06520	COG1414	Transcriptional regulator
F750_RS06525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F750_RS06530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F750_RS06535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F750_RS06540	COG2186	Transcriptional regulator
F750_RS06545	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS06550	COG4948	Mandelate Racemase Muconate Lactonizing
F750_RS06560	COG0215	cysteine-tRNA ligase activity
F750_RS06580	COG0598	Magnesium transport protein CorA
F750_RS06590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS06595	COG0667	Aldo Keto reductase
F750_RS06630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F750_RS06640	COG0564	pseudouridine synthase activity
F750_RS06655	COG2186	Transcriptional regulator
F750_RS06660	COG3265	gluconokinase activity
F750_RS06705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F750_RS06710	COG2149	membrane
F750_RS06730	COG1960	acyl-CoA dehydrogenase activity
F750_RS06735	COG4935	Belongs to the peptidase S8 family
F750_RS06735	COG2234	aminopeptidase activity
F750_RS06745	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS06755	COG3876	Protein conserved in bacteria
F750_RS06770	COG0789	Transcriptional regulator
F750_RS06790	COG1960	acyl-CoA dehydrogenase activity
F750_RS06800	COG0640	Transcriptional regulator
F750_RS06825	COG2851	Citrate transporter
F750_RS06835	COG1309	transcriptional regulator
F750_RS06840	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F750_RS06845	COG2188	Transcriptional regulator
F750_RS06860	COG0515	serine threonine protein kinase
F750_RS06865	COG2755	lipolytic protein G-D-S-L family
F750_RS06880	COG1725	Transcriptional regulator
F750_RS06895	COG2226	methyltransferase
F750_RS06915	COG4565	transcriptional regulatory protein
F750_RS06920	COG3540	Alkaline phosphatase
F750_RS06935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F750_RS06940	COG0587	DNA-directed DNA polymerase activity
F750_RS06975	COG0210	DNA helicase
F750_RS06980	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F750_RS06980	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F750_RS07000	COG1192	Involved in chromosome partitioning
F750_RS07020	COG0515	serine threonine protein kinase
F750_RS07020	COG2815	serine threonine protein kinase
F750_RS07080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F750_RS07090	COG0515	serine threonine protein kinase
F750_RS07120	COG0641	radical SAM
F750_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F750_RS07160	COG1126	abc transporter atp-binding protein
F750_RS07175	COG0765	amino acid transport
F750_RS07190	COG1799	cell septum assembly
F750_RS07195	COG1960	acyl-CoA dehydrogenase activity
F750_RS07200	COG0477	Major facilitator Superfamily
F750_RS07205	COG0671	phosphoesterase, PA-phosphatase related
F750_RS07215	COG0438	transferase activity, transferring glycosyl groups
F750_RS07230	COG1160	GTP binding
F750_RS07240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F750_RS07270	COG3541	Predicted nucleotidyltransferase
F750_RS07280	COG0494	nUDIX hydrolase
F750_RS07295	COG1187	pseudouridine synthase activity
F750_RS07300	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F750_RS07305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F750_RS07320	COG0686	Belongs to the AlaDH PNT family
F750_RS07330	COG0494	nUDIX hydrolase
F750_RS07335	COG0504	CTP synthase activity
F750_RS07340	COG3387	PFAM Glycoside hydrolase 15-related
F750_RS07350	COG0110	maltose O-acetyltransferase activity
F750_RS07365	COG0297	glycogen (starch) synthase activity
F750_RS07370	COG0497	DNA recombination
F750_RS07375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F750_RS07395	COG1120	ATPase activity
F750_RS07400	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS07405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS07410	COG0647	UMP catabolic process
F750_RS07445	COG2094	Belongs to the DNA glycosylase MPG family
F750_RS07455	COG1881	PFAM PEBP family protein
F750_RS07480	COG1119	ATPase activity
F750_RS07490	COG2197	response regulator
F750_RS07505	COG1131	(ABC) transporter
F750_RS07505	COG1716	ATPase activity
F750_RS07505	COG0842	Transport permease protein
F750_RS07510	COG0560	Phosphoserine phosphatase
F750_RS07510	COG3830	Belongs to the UPF0237 family
F750_RS07525	COG2807	transmembrane transport
F750_RS07530	COG2186	Transcriptional regulator
F750_RS07560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F750_RS07580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F750_RS07585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F750_RS07620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F750_RS07635	COG3387	PFAM Glycoside hydrolase 15-related
F750_RS07685	COG0488	(ABC) transporter
F750_RS07705	COG0235	Class ii aldolase
F750_RS07720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F750_RS07725	COG1492	cobalamin metabolic process
F750_RS07740	COG1797	cobyrinic acid a,c-diamide synthase activity
F750_RS07765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F750_RS07780	COG1917	Cupin 2, conserved barrel domain protein
F750_RS07810	COG1175	transmembrane transport
F750_RS07815	COG0395	ABC-type sugar transport system, permease component
F750_RS07830	COG1902	pentaerythritol trinitrate reductase activity
F750_RS07865	COG1414	Transcriptional regulator
F750_RS07870	COG0768	penicillin binding
F750_RS07875	COG2252	PERMEase
F750_RS07900	COG4677	pectinesterase activity
F750_RS07905	COG3866	Pectate lyase
F750_RS07910	COG2755	lipolytic protein G-D-S-L family
F750_RS07935	COG0395	ABC-type sugar transport system, permease component
F750_RS07955	COG1802	Transcriptional regulator
F750_RS07965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F750_RS07970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F750_RS08010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F750_RS08015	COG2171	N-acyltransferase activity
F750_RS08020	COG3226	Transcriptional regulator
F750_RS08025	COG2076	Multidrug Resistance protein
F750_RS08045	COG0822	iron-sulfur transferase activity
F750_RS08050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F750_RS08055	COG0396	ATPase activity
F750_RS08065	COG0719	Fe-S assembly protein
F750_RS08100	COG0109	protoheme IX farnesyltransferase activity
F750_RS08110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F750_RS08125	COG0363	glucosamine-6-phosphate deaminase activity
F750_RS08140	COG0166	Belongs to the GPI family
F750_RS08150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F750_RS08155	COG0149	triose-phosphate isomerase activity
F750_RS08160	COG0126	phosphoglycerate kinase activity
F750_RS08165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F750_RS08170	COG1481	regulation of sporulation
F750_RS08175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F750_RS08180	COG1660	Displays ATPase and GTPase activities
F750_RS08185	COG0322	excinuclease ABC activity
F750_RS08195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F750_RS08225	COG0556	nucleotide-excision repair
F750_RS08235	COG0584	glycerophosphoryl diester phosphodiesterase
F750_RS08240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F750_RS08265	COG0436	Aminotransferase
F750_RS08290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F750_RS08295	COG0330	HflC and HflK could
F750_RS08325	COG0237	dephospho-CoA kinase activity
F750_RS08340	COG2226	methyltransferase
F750_RS08345	COG1643	Atp-dependent helicase
F750_RS08355	COG1309	transcriptional regulator
F750_RS08380	COG2050	protein possibly involved in aromatic compounds catabolism
F750_RS08400	COG0411	ABC transporter
F750_RS08425	COG0737	Belongs to the 5'-nucleotidase family
F750_RS08445	COG1605	Chorismate mutase
F750_RS08445	COG0287	Prephenate dehydrogenase
F750_RS08470	COG1278	Cold shock
F750_RS08475	COG1309	transcriptional regulator
F750_RS08485	COG0705	Rhomboid family
F750_RS08490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F750_RS08500	COG0067	glutamate synthase
F750_RS08500	COG0070	glutamate synthase
F750_RS08500	COG0069	glutamate synthase activity
F750_RS08530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F750_RS08535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F750_RS08540	COG2301	Belongs to the HpcH HpaI aldolase family
F750_RS08545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F750_RS08555	COG0159	tryptophan synthase activity
F750_RS08560	COG0133	tryptophan synthase activity
F750_RS08565	COG0134	indole-3-glycerol-phosphate synthase activity
F750_RS08590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F750_RS08600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F750_RS08605	COG2508	Transcriptional regulator
F750_RS08625	COG2755	lipolytic protein G-D-S-L family
F750_RS08635	COG0107	imidazoleglycerol-phosphate synthase activity
F750_RS08640	COG0251	oxidation-reduction process
F750_RS08645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F750_RS08650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F750_RS08660	COG0131	Imidazoleglycerol-phosphate dehydratase
F750_RS08665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F750_RS08670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F750_RS08695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F750_RS08715	COG1432	Conserved Protein
F750_RS08720	COG0587	DNA-directed DNA polymerase activity
F750_RS08760	COG2153	protein acetylation
F750_RS08770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F750_RS08780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F750_RS08785	COG3599	regulation of cell shape
F750_RS08795	COG1799	cell septum assembly
F750_RS08800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F750_RS08815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F750_RS08820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F750_RS08830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F750_RS08835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F750_RS08845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F750_RS08850	COG0768	penicillin binding
F750_RS08860	COG0275	rRNA processing
F750_RS08870	COG0714	Associated with various cellular activities
F750_RS08890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F750_RS08900	COG1121	(ABC) transporter
F750_RS08905	COG1511	domain protein
F750_RS08920	COG1233	COG1233 Phytoene dehydrogenase and related
F750_RS08935	COG0352	thiamine-phosphate diphosphorylase activity
F750_RS08955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F750_RS08955	COG2022	thiamine diphosphate biosynthetic process
F750_RS08965	COG2022	thiamine diphosphate biosynthetic process
F750_RS08970	COG0515	serine threonine protein kinase
F750_RS08970	COG2815	serine threonine protein kinase
F750_RS08975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F750_RS08980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F750_RS08985	COG2193	ferroxidase activity
F750_RS08995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F750_RS09005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F750_RS09010	COG2197	response regulator
F750_RS09040	COG1940	carbohydrate kinase activity
F750_RS09050	COG0003	Pfam Anion-transporting ATPase
F750_RS09070	COG0438	transferase activity, transferring glycosyl groups
F750_RS09115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F750_RS09120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F750_RS09125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F750_RS09130	COG0723	plastoquinol--plastocyanin reductase activity
F750_RS09135	COG2010	Cytochrome c
F750_RS09140	COG1845	cytochrome c oxidase, subunit III
F750_RS09150	COG1376	ErfK ybiS ycfS ynhG family protein
F750_RS09160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F750_RS09165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F750_RS09175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F750_RS09195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F750_RS09200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F750_RS09205	COG2197	response regulator
F750_RS09210	COG4585	Histidine kinase
F750_RS09230	COG4106	trans-aconitate 2-methyltransferase activity
F750_RS09235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F750_RS09250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F750_RS09260	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F750_RS09265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F750_RS09270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F750_RS09285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F750_RS09320	COG0321	lipoyl(octanoyl) transferase activity
F750_RS09325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F750_RS09405	COG0745	RESPONSE REGULATOR receiver
F750_RS09415	COG2197	response regulator
F750_RS09485	COG0789	Transcriptional regulator
F750_RS09495	COG1595	DNA-templated transcription, initiation
F750_RS09510	COG0366	Alpha amylase catalytic
F750_RS09515	COG0395	ABC-type sugar transport system, permease component
F750_RS09530	COG1609	Transcriptional regulator
F750_RS09540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F750_RS09545	COG2890	protein-(glutamine-N5) methyltransferase activity
F750_RS09550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F750_RS09555	COG0738	Major facilitator superfamily
F750_RS09560	COG0174	glutamine synthetase
F750_RS09580	COG2132	Multicopper oxidase
F750_RS09585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F750_RS09585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F750_RS09590	COG1595	DNA-templated transcription, initiation
F750_RS09600	COG2814	Major facilitator Superfamily
F750_RS09615	COG1309	transcriptional regulator
F750_RS09620	COG0477	Major facilitator Superfamily
F750_RS09625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F750_RS09645	COG1994	Peptidase M50
F750_RS09705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F750_RS09710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS09715	COG1120	ATPase activity
F750_RS09725	COG2837	iron assimilation
F750_RS09730	COG0672	)-iron permease
F750_RS09750	COG1834	amidinotransferase
F750_RS09765	COG2814	Major facilitator Superfamily
F750_RS09775	COG3540	Alkaline phosphatase
F750_RS09800	COG0667	Aldo Keto reductase
F750_RS09805	COG1309	transcriptional regulator
F750_RS09835	COG2124	cytochrome p450
F750_RS09875	COG3022	response to hydroperoxide
F750_RS09880	COG0800	Aldolase
F750_RS09895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F750_RS09900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F750_RS09950	COG0438	transferase activity, transferring glycosyl groups
F750_RS09955	COG1309	transcriptional regulator
F750_RS09975	COG0559	Belongs to the binding-protein-dependent transport system permease family
F750_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS10010	COG1657	PFAM Prenyltransferase squalene oxidase
F750_RS10025	COG3845	ABC transporter
F750_RS10135	COG0494	nUDIX hydrolase
F750_RS10195	COG1358	cellular component organization or biogenesis
F750_RS10240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F750_RS10250	COG0477	Major facilitator Superfamily
F750_RS10255	COG1309	transcriptional regulator
F750_RS10270	COG4585	Histidine kinase
F750_RS10275	COG2197	response regulator
F750_RS10290	COG0667	Aldo Keto reductase
F750_RS10295	COG0789	Transcriptional regulator
F750_RS10340	COG1733	regulation of RNA biosynthetic process
F750_RS10345	COG1741	Belongs to the pirin family
F750_RS10360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F750_RS10365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F750_RS10370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F750_RS10410	COG4213	ABC transporter substrate-binding protein
F750_RS10420	COG4214	carbohydrate transport
F750_RS10435	COG1764	response to oxidative stress
F750_RS10445	COG2130	NADP-dependent
F750_RS10475	COG1522	sequence-specific DNA binding
F750_RS10485	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS10490	COG0825	malonyl-CoA metabolic process
F750_RS10490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F750_RS10500	COG3903	Transcriptional regulator
F750_RS10500	COG3629	intracellular signal transduction
F750_RS10510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS10550	COG1404	Belongs to the peptidase S8 family
F750_RS10595	COG1070	Carbohydrate kinase
F750_RS10610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F750_RS10615	COG0358	DNA primase activity
F750_RS10625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F750_RS10635	COG2949	membrane
F750_RS10640	COG0243	molybdopterin cofactor binding
F750_RS10655	COG0431	NADPH-dependent FMN reductase
F750_RS10685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F750_RS10690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F750_RS10690	COG2146	nitrite reductase [NAD(P)H] activity
F750_RS10695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F750_RS10695	COG2146	nitrite reductase [NAD(P)H] activity
F750_RS10720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F750_RS10720	COG0574	Belongs to the PEP-utilizing enzyme family
F750_RS10735	COG0477	Major facilitator Superfamily
F750_RS10750	COG0423	glycine-tRNA ligase activity
F750_RS10760	COG1121	(ABC) transporter
F750_RS10765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F750_RS10775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F750_RS10780	COG1381	Involved in DNA repair and RecF pathway recombination
F750_RS10790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F750_RS10805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F750_RS10815	COG2315	Protein conserved in bacteria
F750_RS10825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F750_RS10835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F750_RS10845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F750_RS10850	COG1234	tRNA 3'-trailer cleavage
F750_RS10855	COG0537	adenosine 5'-monophosphoramidase activity
F750_RS10870	COG0484	heat shock protein binding
F750_RS10875	COG1420	regulation of RNA biosynthetic process
F750_RS10910	COG0481	GTPase activity
F750_RS10915	COG0268	Binds directly to 16S ribosomal RNA
F750_RS10935	COG2162	N-hydroxyarylamine O-acetyltransferase activity
F750_RS10950	COG1555	photosystem II stabilization
F750_RS10955	COG1307	EDD domain protein, DegV family
F750_RS10965	COG0495	leucyl-tRNA aminoacylation
F750_RS10975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F750_RS10995	COG0588	phosphoglycerate mutase activity
F750_RS11000	COG0799	negative regulation of ribosome biogenesis
F750_RS11010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F750_RS11025	COG0501	Belongs to the peptidase M48B family
F750_RS11040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F750_RS11050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F750_RS11075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F750_RS11080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F750_RS11085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F750_RS11135	COG0673	inositol 2-dehydrogenase activity
F750_RS11140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F750_RS11165	COG0772	Belongs to the SEDS family
F750_RS11185	COG1077	Cell shape determining protein MreB Mrl
F750_RS11190	COG0105	UTP biosynthetic process
F750_RS11200	COG0285	dihydrofolate synthase activity
F750_RS11205	COG0525	valine-tRNA ligase activity
F750_RS11215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F750_RS11220	COG0740	serine-type endopeptidase activity
F750_RS11225	COG0740	serine-type endopeptidase activity
F750_RS11230	COG0544	peptidyl-prolyl cis-trans isomerase activity
F750_RS11255	COG3594	Acyltransferase
F750_RS11265	COG0475	glutathione-regulated potassium exporter activity
F750_RS11275	COG4552	Acetyltransferase involved in intracellular survival and related
F750_RS11290	COG1113	amino acid transport
F750_RS11305	COG1113	amino acid transport
F750_RS11310	COG1113	amino acid transport
F750_RS11320	COG0456	acetyltransferase
F750_RS11325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F750_RS11335	COG2211	Major facilitator Superfamily
F750_RS11345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F750_RS11380	COG4266	Belongs to the allantoicase family
F750_RS11405	COG3291	Pkd domain containing protein
F750_RS11405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F750_RS11415	COG0668	transmembrane transport
F750_RS11420	COG1846	Transcriptional regulator
F750_RS11420	COG1940	carbohydrate kinase activity
F750_RS11425	COG1653	transport
F750_RS11430	COG1175	transmembrane transport
F750_RS11435	COG0395	ABC-type sugar transport system, permease component
F750_RS11440	COG1486	melibiose metabolic process
F750_RS11490	COG2346	COG2346, Truncated hemoglobins
F750_RS11505	COG1136	(ABC) transporter
F750_RS11505	COG0577	efflux transmembrane transporter activity
F750_RS11530	COG0629	single-stranded DNA binding
F750_RS11550	COG0647	UMP catabolic process
F750_RS11565	COG1129	ABC transporter
F750_RS11575	COG1172	Belongs to the binding-protein-dependent transport system permease family
F750_RS11580	COG1879	ABC-type sugar transport system periplasmic component
F750_RS11585	COG3254	rhamnose metabolic process
F750_RS11620	COG3962	Belongs to the TPP enzyme family
F750_RS11625	COG3718	enzyme involved in inositol metabolism
F750_RS11635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F750_RS11650	COG2409	Drug exporters of the RND superfamily
F750_RS11675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F750_RS11685	COG0500	methyltransferase
F750_RS11705	COG1082	Xylose isomerase domain protein TIM barrel
F750_RS11705	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F750_RS11715	COG0673	inositol 2-dehydrogenase activity
F750_RS11720	COG1609	Transcriptional regulator
F750_RS11745	COG0515	serine threonine protein kinase
F750_RS11775	COG1404	Belongs to the peptidase S8 family
F750_RS11800	COG1472	Belongs to the glycosyl hydrolase 3 family
F750_RS11835	COG0028	Belongs to the TPP enzyme family
F750_RS11845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F750_RS11895	COG1175	transmembrane transport
F750_RS11900	COG0395	ABC-type sugar transport system, permease component
F750_RS11905	COG1609	Transcriptional regulator
F750_RS11910	COG1874	Beta-galactosidase
F750_RS11935	COG1946	Acyl-CoA thioesterase
F750_RS11960	COG1309	transcriptional regulator
F750_RS11965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F750_RS11980	COG1960	acyl-CoA dehydrogenase activity
F750_RS12000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F750_RS12020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F750_RS12025	COG0589	response to stress
F750_RS12030	COG4977	sequence-specific DNA binding
F750_RS12065	COG0395	ABC-type sugar transport system, permease component
F750_RS12090	COG0745	RESPONSE REGULATOR receiver
F750_RS12100	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F750_RS12165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS12180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F750_RS12185	COG0765	amino acid transport
F750_RS12190	COG0765	amino acid transport
F750_RS12195	COG1126	abc transporter atp-binding protein
F750_RS12210	COG3397	chitin binding
F750_RS12255	COG0673	inositol 2-dehydrogenase activity
F750_RS12260	COG4702	Belongs to the UPF0303 family
F750_RS12265	COG0179	Fumarylacetoacetate (FAA) hydrolase
F750_RS12270	COG0706	membrane insertase activity
F750_RS12270	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
F750_RS12310	COG0477	Major facilitator Superfamily
F750_RS12340	COG2362	D-Aminopeptidase
F750_RS12375	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F750_RS12395	COG2197	response regulator
F750_RS12400	COG4585	Histidine kinase
F750_RS12405	COG2409	Drug exporters of the RND superfamily
F750_RS12410	COG2207	Transcriptional regulator
F750_RS12410	COG3708	Transcriptional regulator
F750_RS12450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F750_RS12460	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS12465	COG1396	sequence-specific DNA binding
F750_RS12485	COG1349	DNA-binding transcription factor activity
F750_RS12490	COG0137	argininosuccinate synthase activity
F750_RS12500	COG2733	membrane
F750_RS12530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F750_RS12555	COG0477	Major facilitator Superfamily
F750_RS12570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F750_RS12580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F750_RS12585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F750_RS12590	COG1263	PTS System
F750_RS12595	COG1263	PTS System
F750_RS12600	COG1234	tRNA 3'-trailer cleavage
F750_RS12625	COG1113	amino acid transport
F750_RS12635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F750_RS12645	COG1335	isochorismatase
F750_RS12680	COG0277	FAD linked oxidase domain protein
F750_RS12690	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F750_RS12700	COG1174	glycine betaine transport
F750_RS12710	COG1174	glycine betaine transport
F750_RS12790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F750_RS12795	COG0395	ABC-type sugar transport system, permease component
F750_RS12815	COG1678	Uncharacterized ACR, COG1678
F750_RS12820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F750_RS12825	COG0776	regulation of translation
F750_RS12835	COG3973	AAA domain
F750_RS12835	COG3973	AAA domain
F750_RS12865	COG2223	nitrite transmembrane transporter activity
F750_RS12885	COG0583	DNA-binding transcription factor activity
F750_RS12895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F750_RS12900	COG0793	Belongs to the peptidase S41A family
F750_RS12905	COG2177	Part of the ABC transporter FtsEX involved in
F750_RS12910	COG2884	Cell division ATP-binding protein ftsE
F750_RS12925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F750_RS12930	COG0515	serine threonine protein kinase
F750_RS12935	COG0515	serine threonine protein kinase
F750_RS12940	COG1674	ftsk spoiiie
F750_RS12945	COG1653	transport
F750_RS12950	COG1175	transmembrane transport
F750_RS12955	COG0395	ABC-type sugar transport system, permease component
F750_RS12960	COG0463	Glycosyl transferase, family 2
F750_RS12960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F750_RS12965	COG0438	transferase activity, transferring glycosyl groups
F750_RS12970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F750_RS12975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F750_RS12985	COG2226	methyltransferase
F750_RS12985	COG1073	alpha beta
F750_RS12990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F750_RS12995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F750_RS13000	COG1309	transcriptional regulator
F750_RS13010	COG1134	teichoic acid transport
F750_RS13015	COG2902	Dehydrogenase
F750_RS13035	COG0653	protein targeting
F750_RS13050	COG2197	response regulator
F750_RS13055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F750_RS13065	COG0823	Involved in the tonB-independent uptake of proteins
F750_RS13070	COG5000	phosphorelay sensor kinase activity
F750_RS13070	COG5002	protein histidine kinase activity
F750_RS13075	COG0745	RESPONSE REGULATOR receiver
F750_RS13080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F750_RS13100	COG0714	Associated with various cellular activities
F750_RS13140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F750_RS13150	COG1482	cell wall glycoprotein biosynthetic process
F750_RS13160	COG2835	tetraacyldisaccharide 4'-kinase activity
F750_RS13170	COG1620	l-lactate permease
F750_RS13205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F750_RS13210	COG0778	Nitroreductase
F750_RS13210	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F750_RS13240	COG1316	TRANSCRIPTIONal
F750_RS13255	COG1316	TRANSCRIPTIONal
F750_RS13260	COG0477	Major facilitator Superfamily
F750_RS13265	COG1473	amidohydrolase
F750_RS13275	COG1607	acyl-coa hydrolase
F750_RS13280	COG1316	TRANSCRIPTIONal
F750_RS13310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F750_RS13335	COG2205	protein histidine kinase activity
F750_RS13340	COG0745	RESPONSE REGULATOR receiver
F750_RS13345	COG3104	oligopeptide transport
F750_RS13355	COG1366	Belongs to the anti-sigma-factor antagonist family
F750_RS13360	COG1191	sigma factor activity
F750_RS13370	COG1228	amidohydrolase
F750_RS13380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F750_RS13385	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F750_RS13440	COG2755	lipolytic protein G-D-S-L family
F750_RS13445	COG0183	Belongs to the thiolase family
F750_RS13490	COG4608	Belongs to the ABC transporter superfamily
F750_RS13495	COG0444	Belongs to the ABC transporter superfamily
F750_RS13505	COG0601	transmembrane transport
F750_RS13515	COG1609	Transcriptional regulator
F750_RS13520	COG1136	(ABC) transporter
F750_RS13525	COG0577	efflux transmembrane transporter activity
F750_RS13525	COG1136	(ABC) transporter
F750_RS13530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F750_RS13535	COG1252	NADH dehydrogenase
F750_RS13555	COG0148	phosphopyruvate hydratase activity
F750_RS13570	COG2124	cytochrome p450
F750_RS13585	COG2815	serine threonine protein kinase
F750_RS13585	COG0515	serine threonine protein kinase
F750_RS13625	COG0577	efflux transmembrane transporter activity
F750_RS13630	COG1136	(ABC) transporter
F750_RS13630	COG0577	efflux transmembrane transporter activity
F750_RS13635	COG0477	Major facilitator Superfamily
F750_RS13640	COG0596	Alpha beta hydrolase
F750_RS13650	COG1366	Belongs to the anti-sigma-factor antagonist family
F750_RS13680	COG4585	Histidine kinase
F750_RS13695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F750_RS13700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F750_RS13705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F750_RS13710	COG0193	aminoacyl-tRNA hydrolase activity
F750_RS13720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F750_RS13730	COG1309	transcriptional regulator
F750_RS13740	COG4106	trans-aconitate 2-methyltransferase activity
F750_RS13745	COG1846	Transcriptional regulator
F750_RS13750	COG2197	response regulator
F750_RS13760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F750_RS13775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F750_RS13805	COG0488	(ABC) transporter
F750_RS13820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F750_RS13825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F750_RS13835	COG0084	hydrolase, TatD family'
F750_RS13860	COG0442	prolyl-tRNA aminoacylation
F750_RS13880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F750_RS13880	COG0456	acetyltransferase
F750_RS13890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F750_RS13895	COG1122	ATPase activity
F750_RS13905	COG0310	cobalt ion transport
F750_RS13915	COG2409	Drug exporters of the RND superfamily
F750_RS13925	COG0793	Belongs to the peptidase S41A family
F750_RS13925	COG4946	Tricorn protease homolog
F750_RS13935	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS13945	COG2072	flavoprotein involved in K transport
F750_RS14005	COG0521	Mo-molybdopterin cofactor biosynthetic process
F750_RS14010	COG0315	cyclic pyranopterin monophosphate synthase activity
F750_RS14020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F750_RS14025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F750_RS14050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F750_RS14060	COG1970	mechanosensitive ion channel activity
F750_RS14080	COG0437	4 iron, 4 sulfur cluster binding
F750_RS14085	COG0243	molybdopterin cofactor binding
F750_RS14110	COG1247	-acetyltransferase
F750_RS14115	COG3384	dioxygenase
F750_RS14120	COG1846	Transcriptional regulator
F750_RS14175	COG2378	regulation of single-species biofilm formation
F750_RS14210	COG1686	Belongs to the peptidase S11 family
F750_RS14240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F750_RS14245	COG1902	pentaerythritol trinitrate reductase activity
F750_RS14250	COG0789	Transcriptional regulator
F750_RS14255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F750_RS14265	COG2186	Transcriptional regulator
F750_RS14275	COG2376	Dihydroxyacetone kinase
F750_RS14280	COG0698	ribose 5-phosphate isomerase
F750_RS14285	COG0149	triose-phosphate isomerase activity
F750_RS14290	COG1082	Xylose isomerase domain protein TIM barrel
F750_RS14295	COG2084	Dehydrogenase
F750_RS14305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F750_RS14320	COG0768	penicillin binding
F750_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS14350	COG1309	transcriptional regulator
F750_RS14360	COG1301	dicarboxylic acid transport
F750_RS14375	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F750_RS14385	COG0163	prenyltransferase activity
F750_RS14395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F750_RS14400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F750_RS14420	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS14425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F750_RS14430	COG1333	cytochrome c biogenesis protein
F750_RS14435	COG0785	Cytochrome C biogenesis protein
F750_RS14440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F750_RS14450	COG0406	alpha-ribazole phosphatase activity
F750_RS14455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F750_RS14490	COG2770	Histidine kinase
F750_RS14490	COG2208	phosphoserine phosphatase activity
F750_RS14495	COG0659	secondary active sulfate transmembrane transporter activity
F750_RS14530	COG1742	UPF0060 membrane protein
F750_RS14545	COG1690	Belongs to the RtcB family
F750_RS14565	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F750_RS14570	COG0018	arginyl-trna synthetase
F750_RS14580	COG1595	DNA-templated transcription, initiation
F750_RS14620	COG4585	Histidine kinase
F750_RS14625	COG2197	response regulator
F750_RS14650	COG0113	porphobilinogen synthase activity
F750_RS14660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F750_RS14660	COG1648	precorrin-2 dehydrogenase activity
F750_RS14665	COG0181	hydroxymethylbilane synthase activity
F750_RS14670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F750_RS14675	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F750_RS14720	COG0123	including yeast histone deacetylase and acetoin utilization protein
F750_RS14725	COG2223	nitrite transmembrane transporter activity
F750_RS14730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F750_RS14760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F750_RS14770	COG1129	ABC transporter
F750_RS14770	COG0842	Transport permease protein
F750_RS14790	COG0515	serine threonine protein kinase
F750_RS14790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F750_RS14795	COG0129	dihydroxy-acid dehydratase activity
F750_RS14810	COG1082	Xylose isomerase domain protein TIM barrel
F750_RS14815	COG0248	Ppx GppA phosphatase
F750_RS14835	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F750_RS14840	COG0667	Aldo Keto reductase
F750_RS14895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS14905	COG1194	a g-specific adenine glycosylase
F750_RS14910	COG1595	DNA-templated transcription, initiation
F750_RS14920	COG0745	RESPONSE REGULATOR receiver
F750_RS14925	COG2205	protein histidine kinase activity
F750_RS14930	COG0477	Major facilitator Superfamily
F750_RS14940	COG0739	heme binding
F750_RS14960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F750_RS14980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F750_RS14990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F750_RS14995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F750_RS15010	COG2197	response regulator
F750_RS15025	COG0649	NAD binding
F750_RS15040	COG1174	glycine betaine transport
F750_RS15045	COG1174	glycine betaine transport
F750_RS15050	COG1125	glycine betaine transport
F750_RS15050	COG0517	IMP dehydrogenase activity
F750_RS15065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F750_RS15085	COG0302	gtp cyclohydrolase
F750_RS15100	COG0037	tRNA processing
F750_RS15110	COG2027	D-alanyl-D-alanine carboxypeptidase
F750_RS15115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F750_RS15130	COG0393	Putative heavy-metal-binding
F750_RS15135	COG0655	NAD(P)H dehydrogenase (quinone) activity
F750_RS15140	COG0076	glutamate decarboxylase activity
F750_RS15160	COG2318	DinB family
F750_RS15165	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS15200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F750_RS15200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F750_RS15220	COG2897	thiosulfate sulfurtransferase activity
F750_RS15230	COG1335	isochorismatase
F750_RS15245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F750_RS15250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F750_RS15255	COG1754	DNA topoisomerase type I activity
F750_RS15255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F750_RS15265	COG2890	protein-(glutamine-N5) methyltransferase activity
F750_RS15275	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F750_RS15285	COG1366	Belongs to the anti-sigma-factor antagonist family
F750_RS15290	COG1205	dead DEAH box helicase
F750_RS15290	COG1111	helicase
F750_RS15345	COG0288	reversible hydration of carbon dioxide
F750_RS15350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F750_RS15355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F750_RS15365	COG2267	carboxylic ester hydrolase activity
F750_RS15390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F750_RS15410	COG0003	Pfam Anion-transporting ATPase
F750_RS15420	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F750_RS15425	COG1610	YqeY-like protein
F750_RS15430	COG1408	metallophosphoesterase
F750_RS15440	COG2828	Protein conserved in bacteria
F750_RS15455	COG1309	transcriptional regulator
F750_RS15465	COG0326	Molecular chaperone. Has ATPase activity
F750_RS15470	COG2755	lipolytic protein G-D-S-L family
F750_RS15500	COG1595	DNA-templated transcription, initiation
F750_RS15520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F750_RS15525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F750_RS15540	COG1802	Transcriptional regulator
F750_RS15550	COG0693	protein deglycase activity
F750_RS15565	COG0592	DNA-directed DNA polymerase activity
F750_RS15590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F750_RS15605	COG1131	(ABC) transporter
F750_RS15610	COG3559	Exporter of polyketide antibiotics
F750_RS15620	COG2124	cytochrome p450
F750_RS15625	COG2197	response regulator
F750_RS15630	COG4585	Histidine kinase
F750_RS15640	COG3844	kynureninase activity
F750_RS15645	COG3483	tryptophan 2,3-dioxygenase activity
F750_RS15655	COG0477	Major facilitator Superfamily
F750_RS15660	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F750_RS15665	COG0191	fructose-bisphosphate aldolase activity
F750_RS15670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F750_RS15685	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F750_RS15715	COG0542	response to heat
F750_RS15745	COG0789	Transcriptional regulator
F750_RS15750	COG0484	heat shock protein binding
F750_RS15755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F750_RS15760	COG0443	Heat shock 70 kDa protein
F750_RS15765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F750_RS15770	COG2181	nitrate reductase activity
F750_RS15770	COG0247	lactate metabolic process
F750_RS15780	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F750_RS15785	COG0717	Belongs to the dCTP deaminase family
F750_RS15805	COG3209	COG3209 Rhs family protein
F750_RS15830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F750_RS15860	COG0488	(ABC) transporter
F750_RS15875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F750_RS15900	COG1309	transcriptional regulator
F750_RS15920	COG3594	Acyltransferase
F750_RS15930	COG0513	Belongs to the DEAD box helicase family
F750_RS15935	COG1278	Cold shock
F750_RS15975	COG1585	Membrane protein implicated in regulation of membrane protease activity
F750_RS15980	COG2268	Band 7 protein
F750_RS15990	COG0490	domain, Protein
F750_RS15995	COG0475	glutathione-regulated potassium exporter activity
F750_RS16030	COG2255	four-way junction helicase activity
F750_RS16040	COG0180	Tryptophanyl-tRNA synthetase
F750_RS16045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS16070	COG0604	alcohol dehydrogenase
F750_RS16095	COG2205	protein histidine kinase activity
F750_RS16100	COG0745	RESPONSE REGULATOR receiver
F750_RS16105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F750_RS16120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F750_RS16130	COG0628	permease
F750_RS16135	COG1741	Belongs to the pirin family
F750_RS16145	COG1960	acyl-CoA dehydrogenase activity
F750_RS16150	COG1362	aminopeptidase activity
F750_RS16160	COG3629	intracellular signal transduction
F750_RS16160	COG3903	Transcriptional regulator
F750_RS16180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F750_RS16205	COG0508	dehydrogenase complex catalyzes the overall conversion of
F750_RS16210	COG0022	dehydrogenase e1 component
F750_RS16235	COG0515	serine threonine protein kinase
F750_RS16240	COG0515	serine threonine protein kinase
F750_RS16255	COG3321	synthase
F750_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS16255	COG0604	alcohol dehydrogenase
F750_RS16260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F750_RS16290	COG1522	sequence-specific DNA binding
F750_RS16295	COG1309	transcriptional regulator
F750_RS16320	COG3396	Phenylacetate-CoA oxygenase
F750_RS16325	COG3460	Phenylacetate-CoA oxygenase
F750_RS16330	COG3396	Phenylacetate-CoA oxygenase
F750_RS16335	COG2151	metal-sulfur cluster biosynthetic enzyme
F750_RS16340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F750_RS16345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F750_RS16370	COG1733	regulation of RNA biosynthetic process
F750_RS16375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F750_RS16385	COG1716	ATPase activity
F750_RS16390	COG1716	ATPase activity
F750_RS16405	COG0768	penicillin binding
F750_RS16410	COG0515	serine threonine protein kinase
F750_RS16415	COG3764	Sortase (surface protein transpeptidase)
F750_RS16420	COG3764	Sortase (surface protein transpeptidase)
F750_RS16445	COG0705	Rhomboid family
F750_RS16470	COG0515	serine threonine protein kinase
F750_RS16495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F750_RS16505	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F750_RS16510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F750_RS16515	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F750_RS16520	COG0592	DNA-directed DNA polymerase activity
F750_RS16530	COG0706	membrane insertase activity
F750_RS16545	COG1192	Involved in chromosome partitioning
F750_RS16560	COG3118	belongs to the thioredoxin family
F750_RS16565	COG0492	ferredoxin-NADP+ reductase activity
F750_RS16575	COG1595	DNA-templated transcription, initiation
F750_RS16580	COG2815	serine threonine protein kinase
F750_RS16580	COG0515	serine threonine protein kinase
F750_RS16595	COG0617	tRNA 3'-terminal CCA addition
F750_RS16615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F750_RS16640	COG0360	Binds together with S18 to 16S ribosomal RNA
F750_RS16645	COG0629	single-stranded DNA binding
F750_RS16650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F750_RS16655	COG0359	binds to the 23S rRNA
F750_RS16665	COG0305	Participates in initiation and elongation during chromosome replication
F750_RS16690	COG2814	Major facilitator Superfamily
F750_RS16705	COG0626	cystathionine gamma-synthase activity
F750_RS16710	COG1950	PFAM Membrane protein of
F750_RS16715	COG0662	Cupin 2, conserved barrel domain protein
F750_RS16740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F750_RS16750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F750_RS16755	COG1609	Transcriptional regulator
F750_RS16760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F750_RS16765	COG1271	oxidase subunit
F750_RS16770	COG1294	oxidase, subunit
F750_RS16775	COG4988	ABC transporter
F750_RS16785	COG0561	phosphatase activity
F750_RS16800	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F750_RS16810	COG1131	(ABC) transporter
F750_RS16840	COG0561	phosphatase activity
F750_RS16845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F750_RS16855	COG2837	iron assimilation
F750_RS16860	COG2372	response to copper ion
F750_RS16870	COG1999	signal sequence binding
F750_RS16890	COG0006	proline dipeptidase activity
F750_RS16905	COG0653	protein targeting
F750_RS16920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F750_RS17035	COG1595	DNA-templated transcription, initiation
F750_RS17040	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS17065	COG1252	NADH dehydrogenase
F750_RS17095	COG0745	RESPONSE REGULATOR receiver
F750_RS17100	COG2205	protein histidine kinase activity
F750_RS17105	COG1215	transferase activity, transferring glycosyl groups
F750_RS17110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F750_RS17115	COG0477	Major facilitator Superfamily
F750_RS17130	COG3467	pyridoxamine 5'-phosphate
F750_RS17135	COG2353	YceI-like domain
F750_RS17140	COG0477	Major facilitator Superfamily
F750_RS17155	COG1191	sigma factor activity
F750_RS17160	COG1191	sigma factor activity
F750_RS17170	COG0477	Major facilitator Superfamily
F750_RS17200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F750_RS17215	COG2234	aminopeptidase activity
F750_RS17225	COG3795	YCII-related domain
F750_RS17240	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F750_RS17265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F750_RS17330	COG0151	Belongs to the GarS family
F750_RS17345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F750_RS17375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F750_RS17380	COG0047	phosphoribosylformylglycinamidine synthase activity
F750_RS17385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F750_RS17415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F750_RS17425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F750_RS17445	COG1643	Atp-dependent helicase
F750_RS17450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F750_RS17450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F750_RS17485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F750_RS17490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F750_RS17500	COG0513	Belongs to the DEAD box helicase family
F750_RS17625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F750_RS17625	COG1372	Participates in initiation and elongation during chromosome replication
F750_RS17665	COG1653	transport
F750_RS17695	COG1196	nuclear chromosome segregation
F750_RS17695	COG0741	lytic transglycosylase activity
F750_RS17695	COG0739	heme binding
F750_RS17710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F750_RS17715	COG0579	oxidoreductase
F750_RS17740	COG1252	NADH dehydrogenase
F750_RS17755	COG1846	Transcriptional regulator
F750_RS17825	COG0667	Aldo Keto reductase
F750_RS17890	COG0741	lytic transglycosylase activity
F750_RS17890	COG1196	nuclear chromosome segregation
F750_RS17890	COG0739	heme binding
F750_RS17895	COG0671	phosphoesterase, PA-phosphatase related
F750_RS17915	COG1937	Protein conserved in bacteria
F750_RS17925	COG0306	phosphate transporter
F750_RS17930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F750_RS17950	COG0406	alpha-ribazole phosphatase activity
F750_RS17950	COG0494	nUDIX hydrolase
F750_RS17970	COG1116	anion transmembrane transporter activity
F750_RS17975	COG1725	Transcriptional regulator
F750_RS17980	COG0456	acetyltransferase
F750_RS17990	COG0737	Belongs to the 5'-nucleotidase family
F750_RS17995	COG0823	Involved in the tonB-independent uptake of proteins
F750_RS18015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F750_RS18020	COG1609	Transcriptional regulator
F750_RS18025	COG0745	RESPONSE REGULATOR receiver
F750_RS18050	COG2897	thiosulfate sulfurtransferase activity
F750_RS18090	COG3485	protocatechuate 3,4-dioxygenase
F750_RS18105	COG1490	D-aminoacyl-tRNA deacylase activity
F750_RS18120	COG4552	Acetyltransferase involved in intracellular survival and related
F750_RS18125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F750_RS18160	COG3467	pyridoxamine 5'-phosphate
F750_RS18170	COG2318	DinB family
F750_RS18205	COG0438	transferase activity, transferring glycosyl groups
F750_RS18225	COG0697	spore germination
F750_RS18230	COG1846	Transcriptional regulator
F750_RS18255	COG0588	phosphoglycerate mutase activity
F750_RS18270	COG5002	protein histidine kinase activity
F750_RS18285	COG1329	Transcriptional regulator
F750_RS18290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F750_RS18295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F750_RS18320	COG0215	cysteine-tRNA ligase activity
F750_RS18325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F750_RS18345	COG3842	ATPase activity
F750_RS18365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F750_RS18380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F750_RS18395	COG2197	response regulator
F750_RS18400	COG4585	Histidine kinase
F750_RS18420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F750_RS18430	COG3300	MHYT domain
F750_RS18430	COG5001	Diguanylate cyclase
F750_RS18465	COG1877	trehalose-phosphatase activity
F750_RS18465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F750_RS18470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F750_RS18475	COG0463	Glycosyl transferase, family 2
F750_RS18500	COG2318	DinB family
F750_RS18515	COG0604	alcohol dehydrogenase
F750_RS18515	COG3321	synthase
F750_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS18580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F750_RS18585	COG1737	Transcriptional regulator
F750_RS18630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F750_RS18635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F750_RS18640	COG1984	allophanate hydrolase subunit 2
F750_RS18655	COG2409	Drug exporters of the RND superfamily
F750_RS18660	COG0531	amino acid
F750_RS18665	COG3973	AAA domain
F750_RS18675	COG1061	Type III restriction enzyme res subunit
F750_RS18695	COG0110	maltose O-acetyltransferase activity
F750_RS18700	COG3226	Transcriptional regulator
F750_RS18705	COG1120	ATPase activity
F750_RS18710	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS18715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS18735	COG1278	Cold shock
F750_RS18740	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F750_RS18745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F750_RS18755	COG2814	Major facilitator Superfamily
F750_RS18780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F750_RS18790	COG2252	PERMEase
F750_RS18815	COG0667	Aldo Keto reductase
F750_RS18820	COG2267	carboxylic ester hydrolase activity
F750_RS18825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F750_RS18840	COG2197	response regulator
F750_RS18845	COG4585	Histidine kinase
F750_RS18875	COG0667	Aldo Keto reductase
F750_RS18910	COG1136	(ABC) transporter
F750_RS18940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F750_RS18970	COG0642	Histidine kinase
F750_RS18975	COG1316	TRANSCRIPTIONal
F750_RS18980	COG0247	lactate metabolic process
F750_RS18980	COG0277	FAD linked oxidase domain protein
F750_RS18985	COG0583	DNA-binding transcription factor activity
F750_RS18990	COG5006	permease, DMT superfamily
F750_RS18995	COG2318	DinB family
F750_RS19000	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
F750_RS19020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F750_RS19035	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS19040	COG1024	Enoyl-CoA hydratase
F750_RS19085	COG0259	pyridoxamine-phosphate oxidase activity
F750_RS19105	COG4821	SIS domain
F750_RS19125	COG1131	(ABC) transporter
F750_RS19200	COG2072	flavoprotein involved in K transport
F750_RS19210	COG0501	Belongs to the peptidase M48B family
F750_RS19215	COG0259	pyridoxamine-phosphate oxidase activity
F750_RS19220	COG1309	transcriptional regulator
F750_RS19230	COG0515	serine threonine protein kinase
F750_RS19230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F750_RS19260	COG1278	Cold shock
F750_RS19265	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F750_RS19275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F750_RS19290	COG2226	methyltransferase
F750_RS19310	COG0791	NLP P60 protein
F750_RS19310	COG1388	LysM domain
F750_RS19310	COG3103	Sh3 type 3 domain protein
F750_RS19320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F750_RS19325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F750_RS19330	COG0649	NAD binding
F750_RS19340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F750_RS19345	COG1034	ATP synthesis coupled electron transport
F750_RS19350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F750_RS19355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F750_RS19360	COG0839	Belongs to the complex I subunit 6 family
F750_RS19365	COG0713	ATP synthesis coupled electron transport
F750_RS19370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F750_RS19380	COG1007	ATP synthesis coupled electron transport
F750_RS19385	COG0514	ATP-dependent DNA helicase (RecQ)
F750_RS19400	COG0179	Fumarylacetoacetate (FAA) hydrolase
F750_RS19410	COG3104	oligopeptide transport
F750_RS19415	COG0142	geranyltranstransferase activity
F750_RS19435	COG1309	transcriptional regulator
F750_RS19440	COG0561	phosphatase activity
F750_RS19465	COG0702	epimerase
F750_RS19470	COG1733	regulation of RNA biosynthetic process
F750_RS19475	COG1013	pyruvate-flavodoxin oxidoreductase activity
F750_RS19480	COG0674	pyruvate-flavodoxin oxidoreductase activity
F750_RS19480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F750_RS19500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F750_RS19505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F750_RS19510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F750_RS19515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F750_RS19520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F750_RS19525	COG0839	Belongs to the complex I subunit 6 family
F750_RS19530	COG0713	ATP synthesis coupled electron transport
F750_RS19545	COG1007	ATP synthesis coupled electron transport
F750_RS19550	COG1970	mechanosensitive ion channel activity
F750_RS19555	COG0501	Belongs to the peptidase M48B family
F750_RS19560	COG3304	Inner membrane component domain
F750_RS19565	COG2261	transglycosylase associated protein
F750_RS19570	COG1666	GTP binding
F750_RS19595	COG2814	Major facilitator Superfamily
F750_RS19600	COG0702	epimerase
F750_RS19620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F750_RS19625	COG2030	dehydratase
F750_RS19635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F750_RS19640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F750_RS19645	COG0436	Aminotransferase
F750_RS19665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F750_RS19670	COG0081	regulation of translation
F750_RS19675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F750_RS19680	COG0222	ribosome binding
F750_RS19685	COG0085	RNA polymerase activity
F750_RS19690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F750_RS19695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F750_RS19700	COG0049	tRNA binding
F750_RS19705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F750_RS19710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F750_RS19720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F750_RS19740	COG0051	transcription antitermination factor activity, RNA binding
F750_RS19745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F750_RS19750	COG0088	Forms part of the polypeptide exit tunnel
F750_RS19755	COG0089	rRNA binding
F750_RS19760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F750_RS19765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F750_RS19770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F750_RS19775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F750_RS19780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F750_RS19785	COG0255	Belongs to the universal ribosomal protein uL29 family
F750_RS19790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F750_RS19795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F750_RS19800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F750_RS19805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F750_RS19810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F750_RS19815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F750_RS19820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F750_RS19825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F750_RS19830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F750_RS19835	COG1841	ribosomal large subunit assembly
F750_RS19840	COG0200	Binds to the 23S rRNA
F750_RS19850	COG0563	adenylate kinase activity
F750_RS19860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F750_RS19865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F750_RS19870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F750_RS19875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F750_RS19880	COG0202	RNA polymerase activity
F750_RS19885	COG0203	ribosomal protein L17
F750_RS19890	COG0101	tRNA pseudouridine synthase activity
F750_RS19905	COG0488	(ABC) transporter
F750_RS19910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F750_RS19915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F750_RS19920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F750_RS19935	COG1072	(Pantothenic acid kinase))
F750_RS19945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F750_RS19950	COG0736	holo-[acyl-carrier-protein] synthase activity
F750_RS19965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F750_RS19975	COG0802	atpase or kinase
F750_RS20000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F750_RS20015	COG4941	Belongs to the sigma-70 factor family
F750_RS20040	COG0726	polysaccharide deacetylase
F750_RS20045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F750_RS20055	COG4221	oxidoreductase activity
F750_RS20060	COG2258	MOSC domain
F750_RS20065	COG0583	DNA-binding transcription factor activity
F750_RS20080	COG1595	DNA-templated transcription, initiation
F750_RS20090	COG0516	GMP reductase activity
F750_RS20105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F750_RS20110	COG0515	serine threonine protein kinase
F750_RS20120	COG0515	serine threonine protein kinase
F750_RS20145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F750_RS20145	COG0519	Catalyzes the synthesis of GMP from XMP
F750_RS20180	COG2197	response regulator
F750_RS20220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS20220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS20235	COG0714	Associated with various cellular activities
F750_RS20240	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F750_RS20245	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F750_RS20250	COG0045	succinate-CoA ligase (ADP-forming) activity
F750_RS20280	COG0138	bifunctional purine biosynthesis protein purh
F750_RS20295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F750_RS20310	COG0039	L-malate dehydrogenase activity
F750_RS20315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F750_RS20320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F750_RS20330	COG0754	glutathionylspermidine amidase activity
F750_RS20335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F750_RS20340	COG0180	Tryptophanyl-tRNA synthetase
F750_RS20360	COG1295	ribonuclease BN
F750_RS20375	COG1408	metallophosphoesterase
F750_RS20385	COG1309	transcriptional regulator
F750_RS20395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F750_RS20410	COG2009	succinate dehydrogenase
F750_RS20435	COG1595	DNA-templated transcription, initiation
F750_RS20445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS20445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS20460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F750_RS20470	COG1216	Glycosyl transferase, family 2
F750_RS20485	COG2089	acid synthase
F750_RS20495	COG0515	serine threonine protein kinase
F750_RS20495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F750_RS20505	COG1473	amidohydrolase
F750_RS20505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F750_RS20510	COG1744	ABC transporter substrate-binding protein PnrA-like
F750_RS20515	COG3845	ABC transporter
F750_RS20520	COG4603	Belongs to the binding-protein-dependent transport system permease family
F750_RS20525	COG1079	Belongs to the binding-protein-dependent transport system permease family
F750_RS20565	COG2814	Major facilitator Superfamily
F750_RS20570	COG0583	DNA-binding transcription factor activity
F750_RS20580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F750_RS20605	COG2205	protein histidine kinase activity
F750_RS20610	COG0745	RESPONSE REGULATOR receiver
F750_RS20615	COG1595	DNA-templated transcription, initiation
F750_RS20630	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS20635	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS20650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F750_RS20685	COG4770	biotin carboxylase activity
F750_RS20695	COG0424	maF-like protein
F750_RS20705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F750_RS20720	COG1024	Enoyl-CoA hydratase
F750_RS20745	COG1376	ErfK ybiS ycfS ynhG family protein
F750_RS20755	COG1136	(ABC) transporter
F750_RS20760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F750_RS20770	COG2084	Dehydrogenase
F750_RS20775	COG1396	sequence-specific DNA binding
F750_RS20780	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F750_RS20785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F750_RS20810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F750_RS20825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F750_RS20835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F750_RS20845	COG2197	response regulator
F750_RS20870	COG2318	DinB family
F750_RS20905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F750_RS20915	COG1331	Highly conserved protein containing a thioredoxin domain
F750_RS20925	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F750_RS20950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
F750_RS20965	COG1414	Transcriptional regulator
F750_RS20970	COG0251	oxidation-reduction process
F750_RS20975	COG2610	gluconate transmembrane transporter activity
F750_RS21005	COG2894	cell division
F750_RS21040	COG2197	response regulator
F750_RS21060	COG2885	chlorophyll binding
F750_RS21115	COG3135	benzoate transporter
F750_RS21135	COG2226	methyltransferase
F750_RS21150	COG0667	Aldo Keto reductase
F750_RS21155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F750_RS21160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F750_RS21175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F750_RS21180	COG0450	alkyl hydroperoxide reductase
F750_RS21215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F750_RS21230	COG0114	fumarate hydratase activity
F750_RS21235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F750_RS21235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F750_RS21260	COG0778	Nitroreductase
F750_RS21265	COG1722	exodeoxyribonuclease VII activity
F750_RS21270	COG1570	exodeoxyribonuclease VII activity
F750_RS21275	COG0531	amino acid
F750_RS21280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F750_RS21295	COG0012	GTP binding
F750_RS21335	COG3409	Peptidoglycan-binding domain 1 protein
F750_RS21385	COG1842	Phage shock protein A
F750_RS21405	COG0395	ABC-type sugar transport system, permease component
F750_RS21410	COG1175	transmembrane transport
F750_RS21430	COG0477	Major facilitator Superfamily
F750_RS21435	COG1335	isochorismatase
F750_RS21445	COG1217	gtp-binding protein TYPA
F750_RS21460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS21465	COG0444	Belongs to the ABC transporter superfamily
F750_RS21470	COG4608	Belongs to the ABC transporter superfamily
F750_RS21475	COG4166	transmembrane transport
F750_RS21480	COG0601	transmembrane transport
F750_RS21485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS21495	COG4608	Belongs to the ABC transporter superfamily
F750_RS21515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F750_RS21540	COG2912	Transglutaminase-like superfamily
F750_RS21570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F750_RS21575	COG1611	Belongs to the LOG family
F750_RS21580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F750_RS21590	COG0519	Catalyzes the synthesis of GMP from XMP
F750_RS21595	COG1024	Enoyl-CoA hydratase
F750_RS21605	COG1595	DNA-templated transcription, initiation
F750_RS21615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F750_RS21620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F750_RS21655	COG0598	Magnesium transport protein CorA
F750_RS21665	COG2814	Major facilitator Superfamily
F750_RS21680	COG2095	MarC family integral membrane protein
F750_RS21690	COG1432	Conserved Protein
F750_RS21700	COG0513	Belongs to the DEAD box helicase family
F750_RS21740	COG0747	negative chemotaxis
F750_RS21745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS21750	COG0601	transmembrane transport
F750_RS21810	COG0210	DNA helicase
F750_RS21855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F750_RS21905	COG3480	Lon protease (S16) C-terminal proteolytic domain
F750_RS21915	COG1615	UPF0182 protein
F750_RS21940	COG0753	catalase activity
F750_RS21950	COG0483	inositol monophosphate 1-phosphatase activity
F750_RS21960	COG2076	Multidrug Resistance protein
F750_RS21965	COG1162	GTPase activity
F750_RS21970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F750_RS21980	COG2135	peptidase activity
F750_RS21990	COG1595	DNA-templated transcription, initiation
F750_RS21995	COG5662	AntiSigma factor
F750_RS22015	COG0242	peptide deformylase activity
F750_RS22060	COG2188	Transcriptional regulator
F750_RS22065	COG2182	Extracellular solute-binding protein
F750_RS22075	COG0395	ABC-type sugar transport system, permease component
F750_RS22080	COG1472	Belongs to the glycosyl hydrolase 3 family
F750_RS22085	COG0363	glucosamine-6-phosphate deaminase activity
F750_RS22100	COG1597	lipid kinase activity
F750_RS22115	COG2172	sigma factor antagonist activity
F750_RS22140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F750_RS22140	COG1017	nitric oxide dioxygenase activity
F750_RS22145	COG1959	2 iron, 2 sulfur cluster binding
F750_RS22150	COG0277	FAD linked oxidase domain protein
F750_RS22160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F750_RS22165	COG0142	geranyltranstransferase activity
F750_RS22180	COG5640	endopeptidase activity
F750_RS22220	COG4106	trans-aconitate 2-methyltransferase activity
F750_RS22225	COG1126	abc transporter atp-binding protein
F750_RS22230	COG0765	amino acid transport
F750_RS22235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F750_RS22240	COG0281	malic enzyme
F750_RS22245	COG0604	alcohol dehydrogenase
F750_RS22280	COG0508	dehydrogenase complex catalyzes the overall conversion of
F750_RS22280	COG0567	Dehydrogenase, E1 component
F750_RS22285	COG2205	protein histidine kinase activity
F750_RS22290	COG0745	RESPONSE REGULATOR receiver
F750_RS22300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F750_RS22305	COG0726	polysaccharide deacetylase
F750_RS22405	COG0768	penicillin binding
F750_RS22435	COG1793	dna ligase
F750_RS22435	COG3285	dna ligase
F750_RS22440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F750_RS22455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F750_RS22480	COG0018	arginyl-trna synthetase
F750_RS22485	COG0019	diaminopimelate decarboxylase activity
F750_RS22490	COG0460	homoserine dehydrogenase
F750_RS22495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F750_RS22500	COG0083	homoserine kinase activity
F750_RS22515	COG1316	TRANSCRIPTIONal
F750_RS22520	COG0254	rRNA binding
F750_RS22525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F750_RS22530	COG2890	protein-(glutamine-N5) methyltransferase activity
F750_RS22540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F750_RS22545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F750_RS22565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F750_RS22570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F750_RS22575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F750_RS22580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F750_RS22585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F750_RS22590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F750_RS22595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F750_RS22610	COG2197	response regulator
F750_RS22615	COG4585	Histidine kinase
F750_RS22630	COG1250	3-hydroxyacyl-CoA dehydrogenase
F750_RS22645	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F750_RS22700	COG0183	Belongs to the thiolase family
F750_RS22715	COG0745	RESPONSE REGULATOR receiver
F750_RS22720	COG2205	protein histidine kinase activity
F750_RS22780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS22780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS22825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F750_RS22830	COG0857	belongs to the CobB CobQ family
F750_RS22830	COG0280	phosphate acetyltransferase
F750_RS22835	COG0205	6-phosphofructokinase activity
F750_RS22845	COG4565	transcriptional regulatory protein
F750_RS22850	COG3290	protein histidine kinase activity
F750_RS22855	COG1301	dicarboxylic acid transport
F750_RS22875	COG3118	belongs to the thioredoxin family
F750_RS22880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F750_RS22890	COG0366	Alpha amylase catalytic
F750_RS22895	COG0366	Alpha amylase catalytic
F750_RS22900	COG0058	SHG alpha-glucan phosphorylase activity
F750_RS22915	COG1132	(ABC) transporter
F750_RS22920	COG1132	(ABC) transporter
F750_RS22980	COG1131	(ABC) transporter
F750_RS22995	COG1760	l-serine dehydratase
F750_RS23000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F750_RS23005	COG0509	glycine decarboxylation via glycine cleavage system
F750_RS23010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F750_RS23035	COG0747	negative chemotaxis
F750_RS23045	COG0444	Belongs to the ABC transporter superfamily
F750_RS23050	COG4608	Belongs to the ABC transporter superfamily
F750_RS23055	COG2860	membrane
F750_RS23065	COG2378	regulation of single-species biofilm formation
F750_RS23090	COG0515	serine threonine protein kinase
F750_RS23090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F750_RS23105	COG0482	sulfurtransferase activity
F750_RS23125	COG4221	oxidoreductase activity
F750_RS23135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F750_RS23145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F750_RS23150	COG0154	amidase activity
F750_RS23160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F750_RS23170	COG2409	Drug exporters of the RND superfamily
F750_RS23190	COG2197	response regulator
F750_RS23195	COG2133	pyrroloquinoline quinone binding
F750_RS23200	COG0667	Aldo Keto reductase
F750_RS23220	COG0440	acetolactate synthase activity
F750_RS23225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F750_RS23230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F750_RS23235	COG2508	Transcriptional regulator
F750_RS23240	COG0506	proline dehydrogenase activity
F750_RS23245	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS23255	COG1309	transcriptional regulator
F750_RS23260	COG0473	3-isopropylmalate dehydrogenase activity
F750_RS23265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F750_RS23275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F750_RS23285	COG1609	Transcriptional regulator
F750_RS23290	COG4166	transmembrane transport
F750_RS23300	COG0601	transmembrane transport
F750_RS23305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS23310	COG0444	Belongs to the ABC transporter superfamily
F750_RS23320	COG1472	Belongs to the glycosyl hydrolase 3 family
F750_RS23335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS23340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS23345	COG1120	ATPase activity
F750_RS23350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F750_RS23355	COG2326	polyphosphate kinase activity
F750_RS23385	COG1222	aaa ATPase
F750_RS23500	COG1228	amidohydrolase
F750_RS23510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F750_RS23530	COG2018	Roadblock/LC7 domain
F750_RS23550	COG2018	Roadblock/LC7 domain
F750_RS23555	COG5002	protein histidine kinase activity
F750_RS23565	COG0179	Fumarylacetoacetate (FAA) hydrolase
F750_RS23570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F750_RS23605	COG1414	Transcriptional regulator
F750_RS23610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F750_RS23615	COG0066	3-isopropylmalate dehydratase activity
F750_RS23625	COG0776	regulation of translation
F750_RS23635	COG1920	GTP binding
F750_RS23645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F750_RS23650	COG1181	Belongs to the D-alanine--D-alanine ligase family
F750_RS23670	COG0351	phosphomethylpyrimidine kinase
F750_RS23675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F750_RS23680	COG1461	Dihydroxyacetone kinase
F750_RS23685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F750_RS23690	COG0742	ribosomal rna small subunit methyltransferase
F750_RS23695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F750_RS23710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F750_RS23715	COG0571	ribonuclease III activity
F750_RS23720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F750_RS23725	COG1733	regulation of RNA biosynthetic process
F750_RS23735	COG2340	Cysteine-rich secretory protein family
F750_RS23740	COG1254	Belongs to the acylphosphatase family
F750_RS23750	COG1196	nuclear chromosome segregation
F750_RS23755	COG0477	Major facilitator Superfamily
F750_RS23760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F750_RS23790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F750_RS23810	COG0228	four-way junction DNA binding
F750_RS23815	COG1837	Belongs to the UPF0109 family
F750_RS23820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F750_RS23825	COG0336	Belongs to the RNA methyltransferase TrmD family
F750_RS23830	COG0335	large ribosomal subunit rRNA binding
F750_RS23835	COG0681	Belongs to the peptidase S26 family
F750_RS23840	COG0681	Belongs to the peptidase S26 family
F750_RS23845	COG0681	Belongs to the peptidase S26 family
F750_RS23850	COG0681	Belongs to the peptidase S26 family
F750_RS23855	COG1051	belongs to the nudix hydrolase family
F750_RS23865	COG0792	nuclease activity
F750_RS23880	COG1191	sigma factor activity
F750_RS23890	COG0052	Belongs to the universal ribosomal protein uS2 family
F750_RS23895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F750_RS23900	COG0528	UMP kinase activity
F750_RS23905	COG0233	cytoplasmic translational termination
F750_RS23925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F750_RS23940	COG3842	ATPase activity
F750_RS23960	COG4181	ATPase activity
F750_RS23965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F750_RS23975	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS23995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F750_RS24015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F750_RS24020	COG3842	ATPase activity
F750_RS24025	COG1176	ABC-type spermidine putrescine transport system, permease component I
F750_RS24030	COG1177	transmembrane transport
F750_RS24035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F750_RS24065	COG2508	Transcriptional regulator
F750_RS24070	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS24085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F750_RS24090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F750_RS24095	COG0750	zinc metalloprotease
F750_RS24100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F750_RS24115	COG0442	prolyl-tRNA aminoacylation
F750_RS24135	COG0779	Required for maturation of 30S ribosomal subunits
F750_RS24155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F750_RS24165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F750_RS24170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F750_RS24195	COG0444	Belongs to the ABC transporter superfamily
F750_RS24200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS24205	COG0601	transmembrane transport
F750_RS24210	COG0747	negative chemotaxis
F750_RS24215	COG0455	bacterial-type flagellum organization
F750_RS24235	COG3266	domain, Protein
F750_RS24240	COG1404	Belongs to the peptidase S8 family
F750_RS24270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F750_RS24275	COG1674	ftsk spoiiie
F750_RS24285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F750_RS24290	COG1185	polyribonucleotide nucleotidyltransferase activity
F750_RS24295	COG0612	Peptidase, M16
F750_RS24300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F750_RS24320	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F750_RS24325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F750_RS24330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F750_RS24360	COG2208	phosphoserine phosphatase activity
F750_RS24360	COG2770	Histidine kinase
F750_RS24365	COG4999	Histidine kinase
F750_RS24365	COG3850	Histidine kinase
F750_RS24365	COG3437	response regulator, receiver
F750_RS24365	COG2205	protein histidine kinase activity
F750_RS24375	COG1674	ftsk spoiiie
F750_RS24385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F750_RS24395	COG1058	Belongs to the CinA family
F750_RS24395	COG1546	Belongs to the CinA family
F750_RS24400	COG1396	sequence-specific DNA binding
F750_RS24405	COG0783	Belongs to the Dps family
F750_RS24425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F750_RS24430	COG1201	RNA secondary structure unwinding
F750_RS24465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F750_RS24495	COG0765	amino acid transport
F750_RS24500	COG0765	amino acid transport
F750_RS24505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F750_RS24510	COG1126	abc transporter atp-binding protein
F750_RS24520	COG2205	protein histidine kinase activity
F750_RS24525	COG2358	TRAP transporter, solute receptor (TAXI family
F750_RS24530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F750_RS24545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F750_RS24555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F750_RS24560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F750_RS24570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F750_RS24605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F750_RS24610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F750_RS24615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F750_RS24630	COG0588	phosphoglycerate mutase activity
F750_RS24645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F750_RS24675	COG1129	ABC transporter
F750_RS24680	COG2186	Transcriptional regulator
F750_RS24685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F750_RS24710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F750_RS24715	COG4565	transcriptional regulatory protein
F750_RS24720	COG3290	protein histidine kinase activity
F750_RS24735	COG0372	Belongs to the citrate synthase family
F750_RS24740	COG0372	Belongs to the citrate synthase family
F750_RS24750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F750_RS24755	COG0612	Peptidase, M16
F750_RS24770	COG1802	Transcriptional regulator
F750_RS24775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F750_RS24795	COG1435	thymidine kinase activity
F750_RS24830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F750_RS24840	COG0745	RESPONSE REGULATOR receiver
F750_RS24845	COG2205	protein histidine kinase activity
F750_RS24870	COG0756	dUTP diphosphatase activity
F750_RS24880	COG4591	ABC-type transport system involved in lipoprotein release permease component
F750_RS24880	COG1136	(ABC) transporter
F750_RS24910	COG0569	domain protein
F750_RS24915	COG0531	amino acid
F750_RS24920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F750_RS24935	COG1335	isochorismatase
F750_RS24940	COG0702	epimerase
F750_RS24945	COG3631	Ketosteroid isomerase-related protein
F750_RS24955	COG0596	Alpha beta hydrolase
F750_RS24980	COG1396	sequence-specific DNA binding
F750_RS24985	COG1309	transcriptional regulator
F750_RS24990	COG0604	alcohol dehydrogenase
F750_RS24995	COG0596	Alpha beta hydrolase
F750_RS25000	COG3629	intracellular signal transduction
F750_RS25005	COG0515	serine threonine protein kinase
F750_RS25025	COG2366	antibiotic biosynthetic process
F750_RS25045	COG3903	Transcriptional regulator
F750_RS25045	COG3629	intracellular signal transduction
F750_RS25070	COG1937	Protein conserved in bacteria
F750_RS25085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F750_RS25085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F750_RS25090	COG2207	Transcriptional regulator
F750_RS25100	COG1120	ATPase activity
F750_RS25125	COG3291	Pkd domain containing protein
F750_RS25125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F750_RS25145	COG0464	growth
F750_RS25150	COG1404	Belongs to the peptidase S8 family
F750_RS25155	COG1674	ftsk spoiiie
F750_RS25220	COG1309	transcriptional regulator
F750_RS25225	COG3046	protein related to deoxyribodipyrimidine photolyase
F750_RS25230	COG1533	DNA photolyase activity
F750_RS25255	COG1953	Uracil, thiamine, allantoin
F750_RS25265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F750_RS25275	COG0714	Associated with various cellular activities
F750_RS25290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F750_RS25305	COG1414	Transcriptional regulator
F750_RS25310	COG2610	gluconate transmembrane transporter activity
F750_RS25315	COG4948	Mandelate Racemase Muconate Lactonizing
F750_RS25325	COG0583	DNA-binding transcription factor activity
F750_RS25345	COG3585	molybdate ion transport
F750_RS25385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F750_RS25420	COG1799	cell septum assembly
F750_RS25445	COG2040	homocysteine
F750_RS25455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F750_RS25465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F750_RS25470	COG0531	amino acid
F750_RS25480	COG1024	Enoyl-CoA hydratase
F750_RS25500	COG1960	acyl-CoA dehydrogenase activity
F750_RS25515	COG2111	Na H antiporter
F750_RS25515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F750_RS25520	COG1006	Multisubunit Na H antiporter MnhC subunit
F750_RS25525	COG0651	ATP synthesis coupled electron transport
F750_RS25540	COG1320	monovalent cation:proton antiporter activity
F750_RS25555	COG0297	glycogen (starch) synthase activity
F750_RS25560	COG0489	protein tyrosine kinase activity
F750_RS25605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F750_RS25610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F750_RS25615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F750_RS25625	COG0753	catalase activity
F750_RS25660	COG3552	Protein containing von Willebrand factor type A (VWA) domain
F750_RS25665	COG0714	Associated with various cellular activities
F750_RS25695	COG3251	PFAM MbtH domain protein
F750_RS25725	COG1414	Transcriptional regulator
F750_RS25730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F750_RS25740	COG3833	ABC-type maltose transport systems, permease component
F750_RS25745	COG1653	transport
F750_RS25825	COG3209	COG3209 Rhs family protein
F750_RS25825	COG4104	PAAR repeat-containing protein
F750_RS25835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F750_RS25850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F750_RS25855	COG1940	carbohydrate kinase activity
F750_RS25870	COG0395	ABC-type sugar transport system, permease component
F750_RS25875	COG1175	transmembrane transport
F750_RS25890	COG1501	Belongs to the glycosyl hydrolase 31 family
F750_RS25895	COG0588	phosphoglycerate mutase activity
F750_RS25935	COG1653	transport
F750_RS25940	COG1175	transmembrane transport
F750_RS25945	COG0395	ABC-type sugar transport system, permease component
F750_RS25960	COG3409	Peptidoglycan-binding domain 1 protein
F750_RS25965	COG1940	carbohydrate kinase activity
F750_RS25970	COG4213	ABC transporter substrate-binding protein
F750_RS25980	COG4214	carbohydrate transport
F750_RS25985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F750_RS25990	COG0531	amino acid
F750_RS26000	COG1316	TRANSCRIPTIONal
F750_RS26015	COG1250	3-hydroxyacyl-CoA dehydrogenase
F750_RS26015	COG1024	Enoyl-CoA hydratase
F750_RS26020	COG0183	Belongs to the thiolase family
F750_RS26040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F750_RS26045	COG0446	pyridine nucleotide-disulphide oxidoreductase
F750_RS26055	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F750_RS26060	COG3253	May function as heme-dependent peroxidase
F750_RS26075	COG3220	belongs to the UPF0276 family
F750_RS26095	COG4152	abc transporter atp-binding protein
F750_RS26105	COG0726	polysaccharide deacetylase
F750_RS26135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F750_RS26140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F750_RS26145	COG2409	Drug exporters of the RND superfamily
F750_RS26150	COG1309	transcriptional regulator
F750_RS26155	COG0402	S-adenosylhomocysteine deaminase activity
F750_RS26160	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F750_RS26165	COG1802	Transcriptional regulator
F750_RS26180	COG0477	Major facilitator Superfamily
F750_RS26195	COG1063	alcohol dehydrogenase
F750_RS26200	COG0156	8-amino-7-oxononanoate synthase activity
F750_RS26205	COG0583	DNA-binding transcription factor activity
F750_RS26210	COG0346	lactoylglutathione lyase activity
F750_RS26215	COG1072	(Pantothenic acid kinase))
F750_RS26280	COG1175	transmembrane transport
F750_RS26340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F750_RS26355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F750_RS26360	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F750_RS26385	COG0529	Catalyzes the synthesis of activated sulfate
F750_RS26390	COG0175	sulfate reduction
F750_RS26400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F750_RS26410	COG3284	Transcriptional regulator
F750_RS26415	COG1960	acyl-CoA dehydrogenase activity
F750_RS26435	COG1250	3-hydroxyacyl-CoA dehydrogenase
F750_RS26440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F750_RS26445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F750_RS26450	COG0583	DNA-binding transcription factor activity
F750_RS26460	COG0477	Major facilitator Superfamily
F750_RS26475	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F750_RS26480	COG1940	carbohydrate kinase activity
F750_RS26485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F750_RS26490	COG2186	Transcriptional regulator
F750_RS26505	COG3458	cephalosporin-C deacetylase activity
F750_RS26515	COG4166	transmembrane transport
F750_RS26525	COG0444	Belongs to the ABC transporter superfamily
F750_RS26530	COG4608	Belongs to the ABC transporter superfamily
F750_RS26535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F750_RS26580	COG1162	GTPase activity
F750_RS26600	COG0028	Belongs to the TPP enzyme family
F750_RS26630	COG1802	Transcriptional regulator
F750_RS26640	COG3835	regulator
F750_RS26655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F750_RS26660	COG2252	PERMEase
F750_RS26695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F750_RS26720	COG0477	Major facilitator Superfamily
F750_RS26725	COG0435	Glutathione S-transferase
F750_RS26740	COG2197	response regulator
F750_RS26745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F750_RS26750	COG0318	PFAM AMP-dependent synthetase and ligase
F750_RS26765	COG3960	tartronate-semialdehyde synthase activity
F750_RS26775	COG0753	catalase activity
F750_RS26780	COG2084	Dehydrogenase
F750_RS26785	COG3622	Belongs to the hyi family
F750_RS26800	COG0395	ABC-type sugar transport system, permease component
F750_RS26805	COG1175	transmembrane transport
F750_RS26810	COG1653	transport
F750_RS26815	COG2188	Transcriptional regulator
F750_RS26835	COG2351	hydroxyisourate hydrolase activity
F750_RS26845	COG2233	PERMEase
F750_RS26855	COG2233	PERMEase
F750_RS26895	COG3864	Putative metallopeptidase domain
F750_RS26925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F750_RS26940	COG2197	response regulator
F750_RS26945	COG4585	Histidine kinase
F750_RS26955	COG1136	(ABC) transporter
F750_RS26960	COG1414	Transcriptional regulator
F750_RS26965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F750_RS26970	COG4266	Belongs to the allantoicase family
F750_RS26980	COG0656	L-ascorbic acid biosynthetic process
F750_RS27010	COG2197	response regulator
F750_RS27015	COG0673	inositol 2-dehydrogenase activity
F750_RS27020	COG2188	Transcriptional regulator
F750_RS27035	COG1129	ABC transporter
F750_RS27040	COG1940	carbohydrate kinase activity
F750_RS27055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F750_RS27060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F750_RS27085	COG1126	abc transporter atp-binding protein
F750_RS27090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F750_RS27095	COG0765	amino acid transport
F750_RS27100	COG0765	amino acid transport
F750_RS27110	COG2755	lipolytic protein G-D-S-L family
F750_RS27115	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS27120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS27120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS27130	COG2124	cytochrome p450
F750_RS27140	COG2267	carboxylic ester hydrolase activity
F750_RS27160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS27165	COG0019	diaminopimelate decarboxylase activity
F750_RS27180	COG0604	alcohol dehydrogenase
F750_RS27180	COG3321	synthase
F750_RS27185	COG0604	alcohol dehydrogenase
F750_RS27185	COG3321	synthase
F750_RS27205	COG3321	synthase
F750_RS27205	COG0604	alcohol dehydrogenase
F750_RS27210	COG3321	synthase
F750_RS27210	COG0604	alcohol dehydrogenase
F750_RS27215	COG0577	efflux transmembrane transporter activity
F750_RS27215	COG1136	(ABC) transporter
F750_RS27230	COG2197	response regulator
F750_RS27240	COG0405	Gamma-glutamyltransferase
F750_RS27290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F750_RS27295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F750_RS27335	COG1132	(ABC) transporter
F750_RS27340	COG1132	(ABC) transporter
F750_RS27360	COG2226	methyltransferase
F750_RS27370	COG3851	Histidine kinase
F750_RS27375	COG2197	response regulator
F750_RS27380	COG2838	Isocitrate dehydrogenase
F750_RS27385	COG0095	Lipoate-protein ligase
F750_RS27400	COG0483	inositol monophosphate 1-phosphatase activity
F750_RS27405	COG2860	membrane
F750_RS27415	COG0778	Nitroreductase
F750_RS27435	COG0431	NADPH-dependent FMN reductase
F750_RS27480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F750_RS27495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F750_RS27510	COG1929	Belongs to the glycerate kinase type-1 family
F750_RS27530	COG0559	Belongs to the binding-protein-dependent transport system permease family
F750_RS27565	COG0688	phosphatidylethanolamine metabolic process
F750_RS27570	COG1960	acyl-CoA dehydrogenase activity
F750_RS27580	COG2301	Belongs to the HpcH HpaI aldolase family
F750_RS27585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS27585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F750_RS27590	COG0604	alcohol dehydrogenase
F750_RS27610	COG1250	3-hydroxyacyl-CoA dehydrogenase
F750_RS27625	COG0596	Alpha beta hydrolase
F750_RS27665	COG0583	DNA-binding transcription factor activity
F750_RS27670	COG0667	Aldo Keto reductase
F750_RS27675	COG2362	D-Aminopeptidase
F750_RS27680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F750_RS27690	COG1619	proteins homologs of microcin C7 resistance protein MccF
F750_RS27705	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F750_RS27735	COG1414	Transcriptional regulator
F750_RS27760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F750_RS27790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F750_RS27795	COG1077	Cell shape determining protein MreB Mrl
F750_RS27805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F750_RS27805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F750_RS27810	COG3619	membrane
F750_RS27815	COG2154	pterin-4-alpha-carbinolamine dehydratase
F750_RS27820	COG0656	L-ascorbic acid biosynthetic process
F750_RS27860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F750_RS27865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F750_RS27880	COG1129	ABC transporter
F750_RS27885	COG1172	Belongs to the binding-protein-dependent transport system permease family
F750_RS27890	COG1879	ABC-type sugar transport system periplasmic component
F750_RS27915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F750_RS27965	COG1609	Transcriptional regulator
F750_RS27970	COG1129	ABC transporter
F750_RS27975	COG1879	ABC-type sugar transport system periplasmic component
F750_RS27980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F750_RS27985	COG1869	D-ribose catabolic process
F750_RS27995	COG0346	lactoylglutathione lyase activity
F750_RS28060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F750_RS28065	COG2353	YceI-like domain
F750_RS28070	COG0210	DNA helicase
F750_RS28075	COG0515	serine threonine protein kinase
F750_RS28090	COG3209	COG3209 Rhs family protein
F750_RS28225	COG3507	Belongs to the glycosyl hydrolase 43 family
F750_RS28230	COG3940	Belongs to the glycosyl hydrolase 43 family
F750_RS28235	COG0596	Alpha beta hydrolase
F750_RS28240	COG2208	phosphoserine phosphatase activity
F750_RS28240	COG2770	Histidine kinase
F750_RS28275	COG0395	ABC-type sugar transport system, permease component
F750_RS28280	COG4209	transmembrane transport
F750_RS28295	COG1501	Belongs to the glycosyl hydrolase 31 family
F750_RS28305	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS28315	COG0517	IMP dehydrogenase activity
F750_RS28315	COG4175	Glycine betaine
F750_RS28320	COG4176	ABC-type proline glycine betaine transport system permease component
F750_RS28335	COG1136	(ABC) transporter
F750_RS28365	COG1132	(ABC) transporter
F750_RS28370	COG2124	cytochrome p450
F750_RS28395	COG1940	carbohydrate kinase activity
F750_RS28465	COG1486	melibiose metabolic process
F750_RS28495	COG3012	SEC-C Motif Domain Protein
F750_RS28520	COG1960	acyl-CoA dehydrogenase activity
F750_RS28565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F750_RS28625	COG1793	dna ligase
F750_RS28670	COG0488	(ABC) transporter
F750_RS28685	COG1515	deoxyribonuclease V activity
F750_RS28690	COG3268	Saccharopine dehydrogenase
F750_RS28695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F750_RS28700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS28705	COG1960	acyl-CoA dehydrogenase activity
F750_RS28710	COG0183	Belongs to the thiolase family
F750_RS28715	COG1024	Enoyl-CoA hydratase
F750_RS28715	COG1250	3-hydroxyacyl-CoA dehydrogenase
F750_RS28720	COG0789	Transcriptional regulator
F750_RS28735	COG1960	acyl-CoA dehydrogenase activity
F750_RS28745	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS28765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F750_RS28775	COG0488	(ABC) transporter
F750_RS28780	COG2183	response to ionizing radiation
F750_RS28790	COG4977	sequence-specific DNA binding
F750_RS28800	COG1024	Enoyl-CoA hydratase
F750_RS28815	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F750_RS28840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F750_RS28860	COG1388	LysM domain
F750_RS28860	COG1134	teichoic acid transport
F750_RS28865	COG1562	ergosterol biosynthetic process
F750_RS28875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F750_RS28885	COG1657	PFAM Prenyltransferase squalene oxidase
F750_RS28910	COG2365	Tyrosine phosphatase family
F750_RS28920	COG2755	lipolytic protein G-D-S-L family
F750_RS28930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F750_RS28970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F750_RS28975	COG3467	pyridoxamine 5'-phosphate
F750_RS29055	COG0725	ABC transporter, periplasmic molybdate-binding protein
F750_RS29070	COG0072	phenylalanine-tRNA ligase activity
F750_RS29070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F750_RS29095	COG1132	(ABC) transporter
F750_RS29130	COG3958	Transketolase
F750_RS29135	COG3959	Transketolase, thiamine diphosphate binding domain
F750_RS29165	COG2197	response regulator
F750_RS29180	COG2186	Transcriptional regulator
F750_RS29185	COG0247	lactate metabolic process
F750_RS29190	COG1139	Iron-sulfur cluster binding protein
F750_RS29195	COG1556	Lactate utilization protein
F750_RS29210	COG0395	ABC-type sugar transport system, permease component
F750_RS29215	COG1175	transmembrane transport
F750_RS29225	COG1609	Transcriptional regulator
F750_RS29245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F750_RS29275	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F750_RS29275	COG1672	PFAM Archaeal ATPase
F750_RS29310	COG0768	penicillin binding
F750_RS29315	COG2175	clavaminate synthase activity
F750_RS29320	COG0010	Belongs to the arginase family
F750_RS29325	COG0367	asparagine synthase
F750_RS29340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F750_RS29360	COG0747	negative chemotaxis
F750_RS29365	COG0583	DNA-binding transcription factor activity
F750_RS29370	COG4221	oxidoreductase activity
F750_RS29390	COG0697	spore germination
F750_RS29420	COG1295	ribonuclease BN
F750_RS29425	COG0671	phosphoesterase, PA-phosphatase related
F750_RS29445	COG2814	Major facilitator Superfamily
F750_RS29445	COG0477	Major facilitator Superfamily
F750_RS29460	COG2159	amidohydrolase
F750_RS29465	COG2188	Transcriptional regulator
F750_RS29520	COG0446	pyridine nucleotide-disulphide oxidoreductase
F750_RS29520	COG1902	pentaerythritol trinitrate reductase activity
F750_RS29540	COG0702	epimerase
F750_RS29555	COG1846	Transcriptional regulator
F750_RS29560	COG2409	Drug exporters of the RND superfamily
F750_RS29590	COG1122	ATPase activity
F750_RS29595	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F750_RS29600	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
F750_RS29605	COG0310	cobalt ion transport
F750_RS29610	COG0589	response to stress
F750_RS29680	COG1115	amino acid carrier protein
F750_RS29705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS29730	COG0829	nickel cation binding
F750_RS29735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F750_RS29745	COG0804	urea catabolic process
F750_RS29750	COG0832	Belongs to the urease beta subunit family
F750_RS29750	COG0831	urea catabolic process
F750_RS29770	COG2175	clavaminate synthase activity
F750_RS29800	COG3293	Transposase
F750_RS29805	COG0784	Response regulator, receiver
F750_RS29810	COG4251	negative regulation of phosphorylation
F750_RS29820	COG0288	reversible hydration of carbon dioxide
F750_RS29865	COG3415	Transposase
F750_RS29865	COG2801	Transposase and inactivated derivatives
F750_RS29905	COG0494	nUDIX hydrolase
F750_RS29940	COG1051	belongs to the nudix hydrolase family
F750_RS29960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F750_RS29975	COG0302	gtp cyclohydrolase
F750_RS29980	COG0602	queuosine metabolic process
F750_RS30040	COG3387	PFAM Glycoside hydrolase 15-related
F750_RS30085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F750_RS30115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F750_RS30125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F750_RS30135	COG1012	belongs to the aldehyde dehydrogenase family
F750_RS30145	COG1309	transcriptional regulator
F750_RS30155	COG2072	flavoprotein involved in K transport
F750_RS30175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F750_RS30180	COG0019	diaminopimelate decarboxylase activity
F750_RS30195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F750_RS30215	COG1132	(ABC) transporter
F750_RS30225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F750_RS30235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F750_RS30265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F750_RS30270	COG1124	(ABC) transporter
F750_RS30275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F750_RS30315	COG0395	ABC-type sugar transport system, permease component
F750_RS30320	COG1175	transmembrane transport
F750_RS30355	COG0784	Response regulator, receiver
F750_RS30360	COG4251	negative regulation of phosphorylation
F750_RS30365	COG4566	intracellular signal transduction
F750_RS30370	COG1191	sigma factor activity
F750_RS30375	COG2814	Major facilitator Superfamily
F750_RS30420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F750_RS30435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F750_RS30440	COG3275	phosphorelay sensor kinase activity
F750_RS30470	COG0726	polysaccharide deacetylase
F750_RS30515	COG0583	DNA-binding transcription factor activity
F750_RS30525	COG1053	succinate dehydrogenase
F750_RS30530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F750_RS30550	COG3360	Dodecin
F750_RS30555	COG2182	Extracellular solute-binding protein
F750_RS30570	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F750_RS30575	COG0121	glutamine amidotransferase
F750_RS30580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F750_RS30585	COG3572	ergothioneine biosynthetic process
F750_RS30600	COG1609	Transcriptional regulator
F750_RS30610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F750_RS30615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F750_RS30635	COG0477	Major facilitator Superfamily
F750_RS30660	COG4948	Mandelate Racemase Muconate Lactonizing
F750_RS30670	COG1175	transmembrane transport
F750_RS30680	COG2188	Transcriptional regulator
F750_RS30690	COG1064	alcohol dehydrogenase
F750_RS30700	COG0784	Response regulator, receiver
F750_RS30705	COG4251	negative regulation of phosphorylation
F750_RS30720	COG3469	chitinase activity
F750_RS30725	COG0783	Belongs to the Dps family
F750_RS30730	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS30735	COG2391	methyltransferase activity
F750_RS30745	COG0142	geranyltranstransferase activity
F750_RS30760	COG5002	protein histidine kinase activity
F750_RS30780	COG3537	Alpha-1,2-mannosidase
F750_RS30790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F750_RS30810	COG1132	(ABC) transporter
F750_RS30815	COG3507	Belongs to the glycosyl hydrolase 43 family
F750_RS30830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F750_RS30835	COG0142	geranyltranstransferase activity
F750_RS30855	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F750_RS30890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F750_RS30895	COG0596	Alpha beta hydrolase
F750_RS30920	COG0697	spore germination
F750_RS30930	COG2045	Belongs to the ComB family
F750_RS30935	COG1335	isochorismatase
F750_RS30945	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS30950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F750_RS30960	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS30980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F750_RS31030	COG1120	ATPase activity
F750_RS31040	COG3486	L-lysine 6-monooxygenase (NADPH) activity
F750_RS31045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS31050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F750_RS31055	COG1120	ATPase activity
F750_RS31060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F750_RS31065	COG1132	(ABC) transporter
F750_RS31075	COG1132	(ABC) transporter
F750_RS31110	COG2382	esterase
F750_RS31115	COG1414	Transcriptional regulator
F750_RS31120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F750_RS31135	COG2223	nitrite transmembrane transporter activity
F750_RS31145	COG0640	Transcriptional regulator
F750_RS31150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS31165	COG0009	L-threonylcarbamoyladenylate synthase
F750_RS31205	COG3458	cephalosporin-C deacetylase activity
F750_RS31215	COG0656	L-ascorbic acid biosynthetic process
F750_RS31245	COG1960	acyl-CoA dehydrogenase activity
F750_RS31250	COG1960	acyl-CoA dehydrogenase activity
F750_RS31290	COG2890	protein-(glutamine-N5) methyltransferase activity
F750_RS31300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F750_RS31300	COG1796	DNA polymerase
F750_RS31380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F750_RS31440	COG2018	Roadblock/LC7 domain
F750_RS31465	COG1024	Enoyl-CoA hydratase
F750_RS31470	COG1070	Carbohydrate kinase
F750_RS31475	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS31475	COG3347	Dehydrogenase
F750_RS31480	COG4952	isomerase
F750_RS31485	COG0640	Transcriptional regulator
F750_RS31500	COG1357	PFAM Pentapeptide repeats (8 copies)
F750_RS31505	COG2755	lipolytic protein G-D-S-L family
F750_RS31515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F750_RS31525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F750_RS31545	COG2340	Cysteine-rich secretory protein family
F750_RS31555	COG0277	FAD linked oxidase domain protein
F750_RS31570	COG1846	Transcriptional regulator
F750_RS31575	COG1764	response to oxidative stress
F750_RS31610	COG0181	hydroxymethylbilane synthase activity
F750_RS31640	COG0739	heme binding
F750_RS31710	COG4124	Belongs to the glycosyl hydrolase 26 family
F750_RS31710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F750_RS31730	COG2304	oxidoreductase activity
F750_RS31735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F750_RS31805	COG0583	DNA-binding transcription factor activity
F750_RS31810	COG2814	Major facilitator Superfamily
F750_RS31820	COG1032	radical SAM domain protein
F750_RS31825	COG0367	asparagine synthase
F750_RS31860	COG3191	aminopeptidase activity
F750_RS31865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F750_RS31870	COG0010	Belongs to the arginase family
F750_RS31905	COG1233	COG1233 Phytoene dehydrogenase and related
F750_RS31910	COG2130	NADP-dependent
F750_RS31990	COG0189	ligase activity
F750_RS31995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F750_RS32000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F750_RS32005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F750_RS32010	COG3959	Transketolase, thiamine diphosphate binding domain
F750_RS32015	COG3958	Transketolase
F750_RS32030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS32045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F750_RS32050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS32075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS32095	COG2124	cytochrome p450
F750_RS32115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F750_RS32120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F750_RS32130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS32135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F750_RS32140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F750_RS32170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F750_RS32180	COG2197	response regulator
F750_RS32185	COG2423	ornithine cyclodeaminase activity
F750_RS32190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F750_RS32215	COG0395	ABC-type sugar transport system, permease component
F750_RS32225	COG1653	transport
F750_RS32230	COG1609	Transcriptional regulator
F750_RS32270	COG0432	Pfam Uncharacterised protein family UPF0047
F750_RS32275	COG2072	flavoprotein involved in K transport
F750_RS32375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F750_RS32400	COG0069	glutamate synthase activity
F750_RS32460	COG2124	cytochrome p450
F750_RS32545	COG1028	Short-chain dehydrogenase reductase Sdr
F750_RS32555	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
F750_RS32595	COG3293	Transposase
F750_RS32730	COG0420	3'-5' exonuclease activity
F750_RS32875	COG2217	Heavy metal translocating P-type atpase
F750_RS33095	COG2319	Wd-40 repeat
F750_RS33095	COG4249	Peptidase C14 caspase catalytic subunit p20
F750_RS33180	COG0596	Alpha beta hydrolase