locus-tag	class	description
GPZ77_RS00040	COG3328	transposase activity
GPZ77_RS00095	COG3328	transposase activity
GPZ77_RS00110	COG1309	transcriptional regulator
GPZ77_RS00155	COG3293	Transposase
GPZ77_RS00160	COG0598	Magnesium transport protein CorA
GPZ77_RS00175	COG3507	Belongs to the glycosyl hydrolase 43 family
GPZ77_RS00180	COG4677	pectinesterase activity
GPZ77_RS00190	COG0504	CTP synthase activity
GPZ77_RS00200	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS00245	COG3409	Peptidoglycan-binding domain 1 protein
GPZ77_RS00360	COG0309	Hydrogenase expression formation protein (HypE)
GPZ77_RS00365	COG0409	Hydrogenase expression formation protein
GPZ77_RS00370	COG0298	carbon dioxide binding
GPZ77_RS00380	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GPZ77_RS00385	COG0375	protein maturation
GPZ77_RS00585	COG0789	Transcriptional regulator
GPZ77_RS00780	COG3401	FG-GAP repeat protein
GPZ77_RS00820	COG1335	isochorismatase
GPZ77_RS00840	COG0778	Nitroreductase
GPZ77_RS00855	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPZ77_RS00860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPZ77_RS00895	COG0671	phosphoesterase, PA-phosphatase related
GPZ77_RS00900	COG1295	ribonuclease BN
GPZ77_RS00940	COG1902	pentaerythritol trinitrate reductase activity
GPZ77_RS00965	COG1595	DNA-templated transcription, initiation
GPZ77_RS00980	COG0778	Nitroreductase
GPZ77_RS00985	COG1846	Transcriptional regulator
GPZ77_RS01020	COG0477	Major facilitator Superfamily
GPZ77_RS01050	COG1104	cysteine desulfurase activity
GPZ77_RS01065	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS01075	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS01090	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS01095	COG0156	8-amino-7-oxononanoate synthase activity
GPZ77_RS01115	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPZ77_RS01150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPZ77_RS01230	COG2267	carboxylic ester hydrolase activity
GPZ77_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS01290	COG2205	protein histidine kinase activity
GPZ77_RS01295	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS01305	COG0531	amino acid
GPZ77_RS01315	COG0515	serine threonine protein kinase
GPZ77_RS01325	COG1136	(ABC) transporter
GPZ77_RS01325	COG0577	efflux transmembrane transporter activity
GPZ77_RS01330	COG4585	Histidine kinase
GPZ77_RS01335	COG2197	response regulator
GPZ77_RS01395	COG2815	serine threonine protein kinase
GPZ77_RS01395	COG0515	serine threonine protein kinase
GPZ77_RS01405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPZ77_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS01480	COG0789	Transcriptional regulator
GPZ77_RS01520	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS01525	COG1175	transmembrane transport
GPZ77_RS01535	COG0366	Alpha amylase catalytic
GPZ77_RS01540	COG1653	transport
GPZ77_RS01550	COG1136	(ABC) transporter
GPZ77_RS01560	COG1525	nuclease
GPZ77_RS01570	COG4941	Belongs to the sigma-70 factor family
GPZ77_RS01575	COG3795	YCII-related domain
GPZ77_RS01585	COG3209	COG3209 Rhs family protein
GPZ77_RS01585	COG4104	PAAR repeat-containing protein
GPZ77_RS01595	COG0346	lactoylglutathione lyase activity
GPZ77_RS01760	COG0697	spore germination
GPZ77_RS01765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPZ77_RS01800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPZ77_RS01810	COG4977	sequence-specific DNA binding
GPZ77_RS01830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPZ77_RS01840	COG3655	Transcriptional regulator
GPZ77_RS01845	COG1278	Cold shock
GPZ77_RS01855	COG0656	L-ascorbic acid biosynthetic process
GPZ77_RS01865	COG1309	transcriptional regulator
GPZ77_RS01885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPZ77_RS01915	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS01955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPZ77_RS01960	COG1024	Enoyl-CoA hydratase
GPZ77_RS01965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPZ77_RS01975	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS01985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPZ77_RS01990	COG3842	ATPase activity
GPZ77_RS01995	COG1178	ABC-type Fe3 transport system permease component
GPZ77_RS02000	COG1840	ABC-type Fe3 transport system, periplasmic component
GPZ77_RS02010	COG0723	plastoquinol--plastocyanin reductase activity
GPZ77_RS02010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPZ77_RS02025	COG0006	proline dipeptidase activity
GPZ77_RS02035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPZ77_RS02035	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPZ77_RS02050	COG3938	Belongs to the proline racemase family
GPZ77_RS02055	COG1802	Transcriptional regulator
GPZ77_RS02070	COG3953	SLT domain
GPZ77_RS02070	COG5412	phage tail tape measure protein
GPZ77_RS02085	COG1556	Lactate utilization protein
GPZ77_RS02090	COG1139	Iron-sulfur cluster binding protein
GPZ77_RS02100	COG1070	Carbohydrate kinase
GPZ77_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS02105	COG3347	Dehydrogenase
GPZ77_RS02110	COG4952	isomerase
GPZ77_RS02145	COG2304	oxidoreductase activity
GPZ77_RS02160	COG0789	Transcriptional regulator
GPZ77_RS02170	COG2814	Major facilitator Superfamily
GPZ77_RS02185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPZ77_RS02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ77_RS02205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPZ77_RS02235	COG2318	DinB family
GPZ77_RS02255	COG3152	Membrane
GPZ77_RS02260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPZ77_RS02340	COG1024	Enoyl-CoA hydratase
GPZ77_RS02350	COG2267	carboxylic ester hydrolase activity
GPZ77_RS02355	COG1357	PFAM Pentapeptide repeats (8 copies)
GPZ77_RS02375	COG1834	amidinotransferase
GPZ77_RS02390	COG2124	cytochrome p450
GPZ77_RS02405	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS02415	COG0387	Pfam Sodium calcium exchanger
GPZ77_RS02425	COG2070	2-Nitropropane dioxygenase
GPZ77_RS02430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GPZ77_RS02435	COG0583	DNA-binding transcription factor activity
GPZ77_RS02445	COG1063	alcohol dehydrogenase
GPZ77_RS02460	COG0515	serine threonine protein kinase
GPZ77_RS02505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPZ77_RS02520	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS02535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPZ77_RS02560	COG2072	flavoprotein involved in K transport
GPZ77_RS02585	COG1024	Enoyl-CoA hydratase
GPZ77_RS02600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPZ77_RS02600	COG2124	cytochrome p450
GPZ77_RS02635	COG2770	Histidine kinase
GPZ77_RS02635	COG2208	phosphoserine phosphatase activity
GPZ77_RS02720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPZ77_RS02720	COG1796	DNA polymerase
GPZ77_RS02745	COG0842	Transport permease protein
GPZ77_RS02745	COG1131	(ABC) transporter
GPZ77_RS02745	COG1716	ATPase activity
GPZ77_RS02775	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS02780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GPZ77_RS02785	COG1802	Transcriptional regulator
GPZ77_RS02810	COG0517	IMP dehydrogenase activity
GPZ77_RS02810	COG0516	GMP reductase activity
GPZ77_RS02850	COG1695	Transcriptional regulator
GPZ77_RS02855	COG2208	phosphoserine phosphatase activity
GPZ77_RS02870	COG2072	flavoprotein involved in K transport
GPZ77_RS02880	COG2124	cytochrome p450
GPZ77_RS02905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GPZ77_RS02930	COG1703	isobutyryl-CoA mutase activity
GPZ77_RS02930	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GPZ77_RS02930	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GPZ77_RS02940	COG2308	Evidence 4 Homologs of previously reported genes of
GPZ77_RS02940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GPZ77_RS02945	COG0367	asparagine synthase
GPZ77_RS02970	COG2376	Dihydroxyacetone kinase
GPZ77_RS02975	COG1461	Dihydroxyacetone kinase
GPZ77_RS02985	COG0310	cobalt ion transport
GPZ77_RS02990	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GPZ77_RS03000	COG1122	ATPase activity
GPZ77_RS03005	COG1902	pentaerythritol trinitrate reductase activity
GPZ77_RS03005	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPZ77_RS03020	COG0523	cobalamin synthesis protein
GPZ77_RS03025	COG2217	Heavy metal translocating P-type atpase
GPZ77_RS03030	COG0640	Transcriptional regulator
GPZ77_RS03045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS03060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPZ77_RS03110	COG1686	Belongs to the peptidase S11 family
GPZ77_RS03115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPZ77_RS03130	COG0784	Response regulator, receiver
GPZ77_RS03130	COG2205	protein histidine kinase activity
GPZ77_RS03140	COG1191	sigma factor activity
GPZ77_RS03150	COG1366	Belongs to the anti-sigma-factor antagonist family
GPZ77_RS03205	COG2838	Isocitrate dehydrogenase
GPZ77_RS03225	COG1175	transmembrane transport
GPZ77_RS03230	COG3833	ABC-type maltose transport systems, permease component
GPZ77_RS03250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPZ77_RS03255	COG1349	DNA-binding transcription factor activity
GPZ77_RS03260	COG3511	phospholipase C
GPZ77_RS03275	COG0513	Belongs to the DEAD box helicase family
GPZ77_RS03280	COG1278	Cold shock
GPZ77_RS03295	COG1595	DNA-templated transcription, initiation
GPZ77_RS03385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GPZ77_RS03450	COG2409	Drug exporters of the RND superfamily
GPZ77_RS03470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPZ77_RS03480	COG2205	protein histidine kinase activity
GPZ77_RS03480	COG0784	Response regulator, receiver
GPZ77_RS03480	COG5002	protein histidine kinase activity
GPZ77_RS03485	COG1191	sigma factor activity
GPZ77_RS03535	COG1191	sigma factor activity
GPZ77_RS03555	COG2770	Histidine kinase
GPZ77_RS03555	COG2208	phosphoserine phosphatase activity
GPZ77_RS03565	COG2172	sigma factor antagonist activity
GPZ77_RS03570	COG1366	Belongs to the anti-sigma-factor antagonist family
GPZ77_RS03575	COG1366	Belongs to the anti-sigma-factor antagonist family
GPZ77_RS03610	COG1191	sigma factor activity
GPZ77_RS03680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPZ77_RS03690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPZ77_RS03730	COG0515	serine threonine protein kinase
GPZ77_RS03730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPZ77_RS03745	COG2755	lipolytic protein G-D-S-L family
GPZ77_RS03760	COG3401	FG-GAP repeat protein
GPZ77_RS03805	COG2814	Major facilitator Superfamily
GPZ77_RS03820	COG2226	methyltransferase
GPZ77_RS03835	COG2084	Dehydrogenase
GPZ77_RS03840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPZ77_RS03845	COG1733	regulation of RNA biosynthetic process
GPZ77_RS03870	COG1595	DNA-templated transcription, initiation
GPZ77_RS03875	COG0346	lactoylglutathione lyase activity
GPZ77_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS03910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPZ77_RS03915	COG0463	Glycosyl transferase, family 2
GPZ77_RS03940	COG0464	growth
GPZ77_RS03950	COG1349	DNA-binding transcription factor activity
GPZ77_RS03985	COG1940	carbohydrate kinase activity
GPZ77_RS04015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPZ77_RS04025	COG1660	Displays ATPase and GTPase activities
GPZ77_RS04035	COG1940	carbohydrate kinase activity
GPZ77_RS04055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GPZ77_RS04115	COG0584	glycerophosphoryl diester phosphodiesterase
GPZ77_RS04135	COG0671	phosphoesterase, PA-phosphatase related
GPZ77_RS04140	COG1309	transcriptional regulator
GPZ77_RS04160	COG0640	Transcriptional regulator
GPZ77_RS04165	COG1902	pentaerythritol trinitrate reductase activity
GPZ77_RS04190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPZ77_RS04195	COG2192	nodulation
GPZ77_RS04205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPZ77_RS04210	COG0859	PFAM glycosyl transferase family 9
GPZ77_RS04220	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS04225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPZ77_RS04230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPZ77_RS04230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPZ77_RS04245	COG4221	oxidoreductase activity
GPZ77_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS04265	COG0028	Belongs to the TPP enzyme family
GPZ77_RS04300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPZ77_RS04305	COG2971	BadF BadG BcrA BcrD
GPZ77_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS04355	COG2890	protein-(glutamine-N5) methyltransferase activity
GPZ77_RS04365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPZ77_RS04365	COG0723	plastoquinol--plastocyanin reductase activity
GPZ77_RS04370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GPZ77_RS04425	COG1609	Transcriptional regulator
GPZ77_RS04435	COG1175	transmembrane transport
GPZ77_RS04460	COG0640	Transcriptional regulator
GPZ77_RS04475	COG3629	intracellular signal transduction
GPZ77_RS04490	COG4214	carbohydrate transport
GPZ77_RS04500	COG4213	ABC transporter substrate-binding protein
GPZ77_RS04560	COG1595	DNA-templated transcription, initiation
GPZ77_RS04565	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GPZ77_RS04625	COG0432	Pfam Uncharacterised protein family UPF0047
GPZ77_RS04640	COG1132	(ABC) transporter
GPZ77_RS04655	COG0673	inositol 2-dehydrogenase activity
GPZ77_RS04665	COG1132	(ABC) transporter
GPZ77_RS04670	COG1132	(ABC) transporter
GPZ77_RS04690	COG1946	Acyl-CoA thioesterase
GPZ77_RS04695	COG0386	Belongs to the glutathione peroxidase family
GPZ77_RS04700	COG2890	protein-(glutamine-N5) methyltransferase activity
GPZ77_RS04715	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS04725	COG0242	peptide deformylase activity
GPZ77_RS04735	COG3442	glutamine amidotransferase
GPZ77_RS04740	COG0205	6-phosphofructokinase activity
GPZ77_RS04760	COG1470	cell adhesion involved in biofilm formation
GPZ77_RS04765	COG0204	Acyl-transferase
GPZ77_RS04770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPZ77_RS04780	COG0829	nickel cation binding
GPZ77_RS04785	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GPZ77_RS04795	COG0804	urea catabolic process
GPZ77_RS04800	COG0832	Belongs to the urease beta subunit family
GPZ77_RS04805	COG0831	urea catabolic process
GPZ77_RS04815	COG0740	serine-type endopeptidase activity
GPZ77_RS04830	COG1280	lysine exporter protein (LysE YggA)
GPZ77_RS04835	COG0583	DNA-binding transcription factor activity
GPZ77_RS04850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPZ77_RS04855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPZ77_RS04860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPZ77_RS04870	COG2226	methyltransferase
GPZ77_RS04880	COG0456	acetyltransferase
GPZ77_RS04900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPZ77_RS04930	COG2188	Transcriptional regulator
GPZ77_RS04935	COG1595	DNA-templated transcription, initiation
GPZ77_RS04950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS04960	COG0626	cystathionine gamma-synthase activity
GPZ77_RS04965	COG1522	sequence-specific DNA binding
GPZ77_RS04975	COG1522	sequence-specific DNA binding
GPZ77_RS04980	COG0419	ATPase involved in DNA repair
GPZ77_RS04985	COG0420	3'-5' exonuclease activity
GPZ77_RS04990	COG1739	Uncharacterized protein family UPF0029
GPZ77_RS04995	COG1832	CoA-binding protein
GPZ77_RS05010	COG0110	maltose O-acetyltransferase activity
GPZ77_RS05015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPZ77_RS05045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPZ77_RS05060	COG0183	Belongs to the thiolase family
GPZ77_RS05065	COG1733	regulation of RNA biosynthetic process
GPZ77_RS05070	COG1968	undecaprenyl-diphosphatase activity
GPZ77_RS05080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPZ77_RS05090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPZ77_RS05120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPZ77_RS05130	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS05170	COG0697	spore germination
GPZ77_RS05245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPZ77_RS05245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPZ77_RS05275	COG1716	ATPase activity
GPZ77_RS05295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GPZ77_RS05325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPZ77_RS05340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS05345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPZ77_RS05360	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GPZ77_RS05370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPZ77_RS05385	COG2018	Roadblock/LC7 domain
GPZ77_RS05430	COG4336	lyase activity
GPZ77_RS05435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPZ77_RS05440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPZ77_RS05445	COG1984	allophanate hydrolase subunit 2
GPZ77_RS05480	COG2364	Membrane
GPZ77_RS05490	COG2270	Major facilitator Superfamily
GPZ77_RS05500	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPZ77_RS05505	COG1216	Glycosyl transferase, family 2
GPZ77_RS05530	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS05545	COG3940	Belongs to the glycosyl hydrolase 43 family
GPZ77_RS05550	COG3940	Belongs to the glycosyl hydrolase 43 family
GPZ77_RS05555	COG0667	Aldo Keto reductase
GPZ77_RS05570	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPZ77_RS05575	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPZ77_RS05585	COG1879	ABC-type sugar transport system periplasmic component
GPZ77_RS05590	COG1609	Transcriptional regulator
GPZ77_RS05610	COG2160	L-arabinose isomerase activity
GPZ77_RS05625	COG1129	ABC transporter
GPZ77_RS05630	COG4214	carbohydrate transport
GPZ77_RS05670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPZ77_RS05675	COG0140	phosphoribosyl-ATP diphosphatase activity
GPZ77_RS05680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPZ77_RS05685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPZ77_RS05685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPZ77_RS05690	COG3201	nicotinamide mononucleotide transporter
GPZ77_RS05710	COG1940	carbohydrate kinase activity
GPZ77_RS05715	COG0738	Major facilitator superfamily
GPZ77_RS05720	COG2233	PERMEase
GPZ77_RS05735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPZ77_RS05745	COG0531	amino acid
GPZ77_RS05765	COG2390	Transcriptional regulator
GPZ77_RS05770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPZ77_RS05785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPZ77_RS05800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPZ77_RS05815	COG0194	GDP metabolic process
GPZ77_RS05825	COG0284	orotidine-5'-phosphate decarboxylase activity
GPZ77_RS05830	COG0167	dihydroorotate dehydrogenase activity
GPZ77_RS05835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPZ77_RS05840	COG0505	Belongs to the CarA family
GPZ77_RS05850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GPZ77_RS05855	COG0540	Belongs to the ATCase OTCase family
GPZ77_RS05860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GPZ77_RS05870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPZ77_RS05875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPZ77_RS05880	COG0006	proline dipeptidase activity
GPZ77_RS05890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPZ77_RS05895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPZ77_RS05900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPZ77_RS05905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPZ77_RS05915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPZ77_RS05920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPZ77_RS05925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPZ77_RS05945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPZ77_RS05965	COG0124	histidyl-tRNA synthetase
GPZ77_RS05980	COG1196	nuclear chromosome segregation
GPZ77_RS05985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPZ77_RS05990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPZ77_RS05995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPZ77_RS06000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPZ77_RS06010	COG2255	four-way junction helicase activity
GPZ77_RS06015	COG0632	four-way junction helicase activity
GPZ77_RS06020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPZ77_RS06025	COG0217	transcriptional regulatory protein
GPZ77_RS06030	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GPZ77_RS06035	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GPZ77_RS06045	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS06095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPZ77_RS06110	COG5002	protein histidine kinase activity
GPZ77_RS06110	COG2176	DNA-directed DNA polymerase activity
GPZ77_RS06160	COG0456	acetyltransferase
GPZ77_RS06160	COG0454	-acetyltransferase
GPZ77_RS06170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPZ77_RS06225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPZ77_RS06225	COG1648	precorrin-2 dehydrogenase activity
GPZ77_RS06230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPZ77_RS06245	COG1464	Belongs to the NlpA lipoprotein family
GPZ77_RS06250	COG2011	ABC-type metal ion transport system permease component
GPZ77_RS06255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPZ77_RS06280	COG0584	glycerophosphoryl diester phosphodiesterase
GPZ77_RS06285	COG0204	Acyl-transferase
GPZ77_RS06285	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS06290	COG0477	Major facilitator Superfamily
GPZ77_RS06305	COG0165	Argininosuccinate lyase
GPZ77_RS06310	COG0137	argininosuccinate synthase activity
GPZ77_RS06325	COG1438	arginine binding
GPZ77_RS06330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPZ77_RS06335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPZ77_RS06340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GPZ77_RS06345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPZ77_RS06370	COG2813	Specifically methylates the guanine in position
GPZ77_RS06385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS06390	COG0697	spore germination
GPZ77_RS06410	COG1051	belongs to the nudix hydrolase family
GPZ77_RS06425	COG0072	phenylalanine-tRNA ligase activity
GPZ77_RS06425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPZ77_RS06430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPZ77_RS06435	COG5002	protein histidine kinase activity
GPZ77_RS06440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPZ77_RS06445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPZ77_RS06450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPZ77_RS06455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GPZ77_RS06500	COG0583	DNA-binding transcription factor activity
GPZ77_RS06530	COG0531	amino acid
GPZ77_RS06535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPZ77_RS06560	COG4175	Glycine betaine
GPZ77_RS06560	COG0517	IMP dehydrogenase activity
GPZ77_RS06565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPZ77_RS06595	COG2124	cytochrome p450
GPZ77_RS06610	COG0805	protein transport
GPZ77_RS06615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPZ77_RS06650	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GPZ77_RS06665	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GPZ77_RS06670	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GPZ77_RS06685	COG4122	O-methyltransferase activity
GPZ77_RS06690	COG1222	aaa ATPase
GPZ77_RS06710	COG0517	IMP dehydrogenase activity
GPZ77_RS06710	COG1994	Peptidase M50
GPZ77_RS06720	COG2197	response regulator
GPZ77_RS06730	COG0747	negative chemotaxis
GPZ77_RS06740	COG1410	methionine synthase
GPZ77_RS06740	COG0646	methionine synthase
GPZ77_RS06745	COG1414	Transcriptional regulator
GPZ77_RS06750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPZ77_RS06755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPZ77_RS06760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPZ77_RS06785	COG0215	cysteine-tRNA ligase activity
GPZ77_RS06805	COG0598	Magnesium transport protein CorA
GPZ77_RS06815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS06820	COG0667	Aldo Keto reductase
GPZ77_RS06850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPZ77_RS06860	COG0564	pseudouridine synthase activity
GPZ77_RS06875	COG1113	amino acid transport
GPZ77_RS06880	COG2186	Transcriptional regulator
GPZ77_RS06885	COG3265	gluconokinase activity
GPZ77_RS06900	COG3573	Dehydrogenase
GPZ77_RS06915	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GPZ77_RS06920	COG2149	membrane
GPZ77_RS06945	COG4948	Mandelate Racemase Muconate Lactonizing
GPZ77_RS06955	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS06965	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS06970	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS06975	COG3876	Protein conserved in bacteria
GPZ77_RS07005	COG0789	Transcriptional regulator
GPZ77_RS07020	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS07030	COG0640	Transcriptional regulator
GPZ77_RS07065	COG2851	Citrate transporter
GPZ77_RS07070	COG0243	molybdopterin cofactor binding
GPZ77_RS07075	COG1309	transcriptional regulator
GPZ77_RS07095	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPZ77_RS07125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GPZ77_RS07140	COG2755	lipolytic protein G-D-S-L family
GPZ77_RS07150	COG1725	Transcriptional regulator
GPZ77_RS07190	COG4565	transcriptional regulatory protein
GPZ77_RS07210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPZ77_RS07215	COG0587	DNA-directed DNA polymerase activity
GPZ77_RS07260	COG1799	cell septum assembly
GPZ77_RS07265	COG0477	Major facilitator Superfamily
GPZ77_RS07270	COG0671	phosphoesterase, PA-phosphatase related
GPZ77_RS07285	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS07310	COG0410	ABC transporter
GPZ77_RS07330	COG1160	GTP binding
GPZ77_RS07340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPZ77_RS07370	COG3541	Predicted nucleotidyltransferase
GPZ77_RS07395	COG1187	pseudouridine synthase activity
GPZ77_RS07400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GPZ77_RS07405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GPZ77_RS07420	COG0686	Belongs to the AlaDH PNT family
GPZ77_RS07430	COG0494	nUDIX hydrolase
GPZ77_RS07435	COG0504	CTP synthase activity
GPZ77_RS07440	COG3387	PFAM Glycoside hydrolase 15-related
GPZ77_RS07455	COG0531	amino acid
GPZ77_RS07465	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS07475	COG0497	DNA recombination
GPZ77_RS07480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPZ77_RS07500	COG1120	ATPase activity
GPZ77_RS07505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS07510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS07545	COG2094	Belongs to the DNA glycosylase MPG family
GPZ77_RS07555	COG1881	PFAM PEBP family protein
GPZ77_RS07580	COG1119	ATPase activity
GPZ77_RS07595	COG2197	response regulator
GPZ77_RS07600	COG4585	Histidine kinase
GPZ77_RS07610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPZ77_RS07620	COG1716	ATPase activity
GPZ77_RS07620	COG1131	(ABC) transporter
GPZ77_RS07620	COG0842	Transport permease protein
GPZ77_RS07625	COG0560	Phosphoserine phosphatase
GPZ77_RS07625	COG3830	Belongs to the UPF0237 family
GPZ77_RS07645	COG2186	Transcriptional regulator
GPZ77_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS07675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPZ77_RS07695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPZ77_RS07700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPZ77_RS07715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GPZ77_RS07745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPZ77_RS07760	COG3387	PFAM Glycoside hydrolase 15-related
GPZ77_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS07800	COG1024	Enoyl-CoA hydratase
GPZ77_RS07810	COG0488	(ABC) transporter
GPZ77_RS07845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GPZ77_RS07850	COG1492	cobalamin metabolic process
GPZ77_RS07865	COG1797	cobyrinic acid a,c-diamide synthase activity
GPZ77_RS07920	COG1104	cysteine desulfurase activity
GPZ77_RS07940	COG5285	phytanoyl-CoA dioxygenase
GPZ77_RS07945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPZ77_RS07960	COG2207	Transcriptional regulator
GPZ77_RS07975	COG1414	Transcriptional regulator
GPZ77_RS07990	COG4585	Histidine kinase
GPZ77_RS07995	COG2197	response regulator
GPZ77_RS08000	COG0768	penicillin binding
GPZ77_RS08025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPZ77_RS08080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPZ77_RS08090	COG2171	N-acyltransferase activity
GPZ77_RS08095	COG3226	Transcriptional regulator
GPZ77_RS08100	COG2076	Multidrug Resistance protein
GPZ77_RS08115	COG2151	metal-sulfur cluster biosynthetic enzyme
GPZ77_RS08120	COG0822	iron-sulfur transferase activity
GPZ77_RS08125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPZ77_RS08130	COG0396	ATPase activity
GPZ77_RS08140	COG0719	Fe-S assembly protein
GPZ77_RS08155	COG1131	(ABC) transporter
GPZ77_RS08180	COG0109	protoheme IX farnesyltransferase activity
GPZ77_RS08190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPZ77_RS08205	COG0363	glucosamine-6-phosphate deaminase activity
GPZ77_RS08225	COG0166	Belongs to the GPI family
GPZ77_RS08240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPZ77_RS08245	COG0149	triose-phosphate isomerase activity
GPZ77_RS08250	COG0126	phosphoglycerate kinase activity
GPZ77_RS08255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPZ77_RS08265	COG1481	regulation of sporulation
GPZ77_RS08275	COG1660	Displays ATPase and GTPase activities
GPZ77_RS08280	COG0322	excinuclease ABC activity
GPZ77_RS08310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPZ77_RS08320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPZ77_RS08325	COG0477	Major facilitator Superfamily
GPZ77_RS08330	COG0861	Integral membrane protein TerC family
GPZ77_RS08345	COG0556	nucleotide-excision repair
GPZ77_RS08355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPZ77_RS08395	COG2313	pseudouridylate synthase activity
GPZ77_RS08400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPZ77_RS08410	COG1733	regulation of RNA biosynthetic process
GPZ77_RS08415	COG0436	Aminotransferase
GPZ77_RS08440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPZ77_RS08465	COG2226	methyltransferase
GPZ77_RS08480	COG0237	dephospho-CoA kinase activity
GPZ77_RS08500	COG2226	methyltransferase
GPZ77_RS08500	COG0596	Alpha beta hydrolase
GPZ77_RS08500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPZ77_RS08505	COG1643	Atp-dependent helicase
GPZ77_RS08540	COG2050	protein possibly involved in aromatic compounds catabolism
GPZ77_RS08555	COG0559	Belongs to the binding-protein-dependent transport system permease family
GPZ77_RS08565	COG0411	ABC transporter
GPZ77_RS08570	COG0410	ABC transporter
GPZ77_RS08595	COG2968	Membrane
GPZ77_RS08600	COG0737	Belongs to the 5'-nucleotidase family
GPZ77_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS08670	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS08675	COG1024	Enoyl-CoA hydratase
GPZ77_RS08715	COG0483	inositol monophosphate 1-phosphatase activity
GPZ77_RS08725	COG1278	Cold shock
GPZ77_RS08730	COG0183	Belongs to the thiolase family
GPZ77_RS08735	COG1309	transcriptional regulator
GPZ77_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS08745	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS08750	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS08755	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS08785	COG0067	glutamate synthase
GPZ77_RS08785	COG0070	glutamate synthase
GPZ77_RS08785	COG0069	glutamate synthase activity
GPZ77_RS08820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPZ77_RS08825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GPZ77_RS08830	COG2301	Belongs to the HpcH HpaI aldolase family
GPZ77_RS08835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPZ77_RS08845	COG0159	tryptophan synthase activity
GPZ77_RS08850	COG0133	tryptophan synthase activity
GPZ77_RS08860	COG0134	indole-3-glycerol-phosphate synthase activity
GPZ77_RS08885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPZ77_RS08905	COG0107	imidazoleglycerol-phosphate synthase activity
GPZ77_RS08910	COG0251	oxidation-reduction process
GPZ77_RS08915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPZ77_RS08920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPZ77_RS08925	COG0131	Imidazoleglycerol-phosphate dehydratase
GPZ77_RS08930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPZ77_RS08935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPZ77_RS08950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPZ77_RS08975	COG1432	Conserved Protein
GPZ77_RS08980	COG0587	DNA-directed DNA polymerase activity
GPZ77_RS09035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPZ77_RS09040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPZ77_RS09045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPZ77_RS09060	COG1799	cell septum assembly
GPZ77_RS09065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPZ77_RS09085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPZ77_RS09095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPZ77_RS09100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPZ77_RS09110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPZ77_RS09115	COG0768	penicillin binding
GPZ77_RS09125	COG0275	rRNA processing
GPZ77_RS09135	COG0714	Associated with various cellular activities
GPZ77_RS09155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPZ77_RS09165	COG1121	(ABC) transporter
GPZ77_RS09170	COG1511	domain protein
GPZ77_RS09185	COG1233	COG1233 Phytoene dehydrogenase and related
GPZ77_RS09200	COG0352	thiamine-phosphate diphosphorylase activity
GPZ77_RS09220	COG2022	thiamine diphosphate biosynthetic process
GPZ77_RS09220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPZ77_RS09225	COG2104	thiamine diphosphate biosynthetic process
GPZ77_RS09230	COG2022	thiamine diphosphate biosynthetic process
GPZ77_RS09235	COG0515	serine threonine protein kinase
GPZ77_RS09235	COG2815	serine threonine protein kinase
GPZ77_RS09240	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPZ77_RS09250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GPZ77_RS09255	COG2193	ferroxidase activity
GPZ77_RS09260	COG0243	molybdopterin cofactor binding
GPZ77_RS09265	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GPZ77_RS09285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPZ77_RS09290	COG0205	6-phosphofructokinase activity
GPZ77_RS09300	COG4585	Histidine kinase
GPZ77_RS09325	COG1940	carbohydrate kinase activity
GPZ77_RS09355	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS09365	COG0534	Mate efflux family protein
GPZ77_RS09380	COG0791	NLP P60 protein
GPZ77_RS09400	COG0705	Rhomboid family
GPZ77_RS09415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPZ77_RS09420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPZ77_RS09425	COG0723	plastoquinol--plastocyanin reductase activity
GPZ77_RS09430	COG2010	Cytochrome c
GPZ77_RS09435	COG1845	cytochrome c oxidase, subunit III
GPZ77_RS09455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPZ77_RS09460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPZ77_RS09490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPZ77_RS09500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPZ77_RS09505	COG2197	response regulator
GPZ77_RS09510	COG4585	Histidine kinase
GPZ77_RS09530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPZ77_RS09535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPZ77_RS09550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPZ77_RS09555	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GPZ77_RS09555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPZ77_RS09570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPZ77_RS09580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPZ77_RS09585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPZ77_RS09590	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPZ77_RS09600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPZ77_RS09615	COG4977	sequence-specific DNA binding
GPZ77_RS09620	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS09665	COG0321	lipoyl(octanoyl) transferase activity
GPZ77_RS09670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPZ77_RS09710	COG1846	Transcriptional regulator
GPZ77_RS09720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS09750	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS09780	COG2365	Tyrosine phosphatase family
GPZ77_RS09835	COG0366	Alpha amylase catalytic
GPZ77_RS09840	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS09845	COG1175	transmembrane transport
GPZ77_RS09850	COG2182	Extracellular solute-binding protein
GPZ77_RS09860	COG1609	Transcriptional regulator
GPZ77_RS09875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPZ77_RS09900	COG0174	glutamine synthetase
GPZ77_RS09925	COG2267	carboxylic ester hydrolase activity
GPZ77_RS09935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPZ77_RS09935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPZ77_RS09940	COG2814	Major facilitator Superfamily
GPZ77_RS09950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPZ77_RS09970	COG1994	Peptidase M50
GPZ77_RS10035	COG1834	amidinotransferase
GPZ77_RS10045	COG2814	Major facilitator Superfamily
GPZ77_RS10095	COG3022	response to hydroperoxide
GPZ77_RS10100	COG0800	Aldolase
GPZ77_RS10110	COG0406	alpha-ribazole phosphatase activity
GPZ77_RS10110	COG0328	RNA-DNA hybrid ribonuclease activity
GPZ77_RS10120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPZ77_RS10125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPZ77_RS10160	COG2197	response regulator
GPZ77_RS10170	COG0183	Belongs to the thiolase family
GPZ77_RS10175	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS10215	COG0860	N-Acetylmuramoyl-L-alanine amidase
GPZ77_RS10225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS10235	COG3866	Pectate lyase
GPZ77_RS10265	COG1309	transcriptional regulator
GPZ77_RS10315	COG3845	ABC transporter
GPZ77_RS10330	COG1309	transcriptional regulator
GPZ77_RS10335	COG0655	NAD(P)H dehydrogenase (quinone) activity
GPZ77_RS10345	COG0183	Belongs to the thiolase family
GPZ77_RS10350	COG2124	cytochrome p450
GPZ77_RS10435	COG1234	tRNA 3'-trailer cleavage
GPZ77_RS10460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPZ77_RS10495	COG1358	cellular component organization or biogenesis
GPZ77_RS10540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPZ77_RS10545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPZ77_RS10555	COG0477	Major facilitator Superfamily
GPZ77_RS10560	COG1309	transcriptional regulator
GPZ77_RS10575	COG4585	Histidine kinase
GPZ77_RS10580	COG2197	response regulator
GPZ77_RS10595	COG0667	Aldo Keto reductase
GPZ77_RS10600	COG0789	Transcriptional regulator
GPZ77_RS10615	COG2205	protein histidine kinase activity
GPZ77_RS10620	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS10625	COG0728	peptidoglycan biosynthetic process
GPZ77_RS10655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPZ77_RS10660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPZ77_RS10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPZ77_RS10720	COG1764	response to oxidative stress
GPZ77_RS10760	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS10765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPZ77_RS10765	COG0825	malonyl-CoA metabolic process
GPZ77_RS10780	COG1846	Transcriptional regulator
GPZ77_RS10785	COG1764	response to oxidative stress
GPZ77_RS10810	COG1070	Carbohydrate kinase
GPZ77_RS10835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPZ77_RS10840	COG0358	DNA primase activity
GPZ77_RS10850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPZ77_RS10865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPZ77_RS10870	COG2949	membrane
GPZ77_RS10875	COG0243	molybdopterin cofactor binding
GPZ77_RS10935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPZ77_RS10940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPZ77_RS10940	COG2146	nitrite reductase [NAD(P)H] activity
GPZ77_RS10945	COG2146	nitrite reductase [NAD(P)H] activity
GPZ77_RS10945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPZ77_RS10950	COG1309	transcriptional regulator
GPZ77_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS10990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPZ77_RS10990	COG0574	Belongs to the PEP-utilizing enzyme family
GPZ77_RS11000	COG0477	Major facilitator Superfamily
GPZ77_RS11010	COG0477	Major facilitator Superfamily
GPZ77_RS11020	COG0667	Aldo Keto reductase
GPZ77_RS11030	COG0423	glycine-tRNA ligase activity
GPZ77_RS11035	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPZ77_RS11035	COG3443	Belongs to the bacterial solute-binding protein 9 family
GPZ77_RS11040	COG1121	(ABC) transporter
GPZ77_RS11045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPZ77_RS11060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPZ77_RS11065	COG1381	Involved in DNA repair and RecF pathway recombination
GPZ77_RS11085	COG2197	response regulator
GPZ77_RS11090	COG0277	FAD linked oxidase domain protein
GPZ77_RS11100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPZ77_RS11115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPZ77_RS11155	COG2315	Protein conserved in bacteria
GPZ77_RS11165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPZ77_RS11185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPZ77_RS11190	COG1234	tRNA 3'-trailer cleavage
GPZ77_RS11195	COG0537	adenosine 5'-monophosphoramidase activity
GPZ77_RS11210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPZ77_RS11230	COG0484	heat shock protein binding
GPZ77_RS11235	COG1420	regulation of RNA biosynthetic process
GPZ77_RS11260	COG0481	GTPase activity
GPZ77_RS11265	COG0268	Binds directly to 16S ribosomal RNA
GPZ77_RS11280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPZ77_RS11285	COG0658	competence protein
GPZ77_RS11285	COG2333	competence protein COMEC
GPZ77_RS11295	COG1307	EDD domain protein, DegV family
GPZ77_RS11305	COG0495	leucyl-tRNA aminoacylation
GPZ77_RS11315	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GPZ77_RS11350	COG0588	phosphoglycerate mutase activity
GPZ77_RS11355	COG0799	negative regulation of ribosome biogenesis
GPZ77_RS11365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPZ77_RS11370	COG0501	Belongs to the peptidase M48B family
GPZ77_RS11385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPZ77_RS11395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPZ77_RS11410	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS11415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GPZ77_RS11420	COG1215	transferase activity, transferring glycosyl groups
GPZ77_RS11425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPZ77_RS11430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPZ77_RS11435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPZ77_RS11440	COG1530	ribonuclease E activity
GPZ77_RS11465	COG0772	Belongs to the SEDS family
GPZ77_RS11470	COG0768	penicillin binding
GPZ77_RS11485	COG1077	Cell shape determining protein MreB Mrl
GPZ77_RS11490	COG0105	UTP biosynthetic process
GPZ77_RS11500	COG0285	dihydrofolate synthase activity
GPZ77_RS11505	COG0525	valine-tRNA ligase activity
GPZ77_RS11515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPZ77_RS11520	COG0740	serine-type endopeptidase activity
GPZ77_RS11525	COG0740	serine-type endopeptidase activity
GPZ77_RS11530	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPZ77_RS11555	COG4552	Acetyltransferase involved in intracellular survival and related
GPZ77_RS11570	COG1113	amino acid transport
GPZ77_RS11585	COG1113	amino acid transport
GPZ77_RS11590	COG1113	amino acid transport
GPZ77_RS11595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GPZ77_RS11600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GPZ77_RS11635	COG0346	lactoylglutathione lyase activity
GPZ77_RS11665	COG4266	Belongs to the allantoicase family
GPZ77_RS11680	COG0697	spore germination
GPZ77_RS11685	COG1846	Transcriptional regulator
GPZ77_RS11705	COG3291	Pkd domain containing protein
GPZ77_RS11705	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GPZ77_RS11715	COG0668	transmembrane transport
GPZ77_RS11730	COG1175	transmembrane transport
GPZ77_RS11735	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS11740	COG1486	melibiose metabolic process
GPZ77_RS11755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ77_RS11785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPZ77_RS11790	COG2346	COG2346, Truncated hemoglobins
GPZ77_RS11805	COG1136	(ABC) transporter
GPZ77_RS11805	COG0577	efflux transmembrane transporter activity
GPZ77_RS11860	COG3585	molybdate ion transport
GPZ77_RS11885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPZ77_RS11890	COG1993	acr, cog1993
GPZ77_RS11895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPZ77_RS11905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS11920	COG2130	NADP-dependent
GPZ77_RS11945	COG2223	nitrite transmembrane transporter activity
GPZ77_RS11950	COG0243	molybdopterin cofactor binding
GPZ77_RS11955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPZ77_RS11960	COG2146	nitrite reductase [NAD(P)H] activity
GPZ77_RS11960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPZ77_RS11980	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS11990	COG2132	Multicopper oxidase
GPZ77_RS12005	COG0367	asparagine synthase
GPZ77_RS12020	COG0655	NAD(P)H dehydrogenase (quinone) activity
GPZ77_RS12100	COG3962	Belongs to the TPP enzyme family
GPZ77_RS12105	COG3718	enzyme involved in inositol metabolism
GPZ77_RS12135	COG2409	Drug exporters of the RND superfamily
GPZ77_RS12160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPZ77_RS12180	COG0673	inositol 2-dehydrogenase activity
GPZ77_RS12185	COG1609	Transcriptional regulator
GPZ77_RS12200	COG1472	Belongs to the glycosyl hydrolase 3 family
GPZ77_RS12230	COG0028	Belongs to the TPP enzyme family
GPZ77_RS12240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPZ77_RS12285	COG1946	Acyl-CoA thioesterase
GPZ77_RS12305	COG1309	transcriptional regulator
GPZ77_RS12310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPZ77_RS12325	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS12355	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GPZ77_RS12380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPZ77_RS12390	COG0589	response to stress
GPZ77_RS12400	COG4977	sequence-specific DNA binding
GPZ77_RS12405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPZ77_RS12435	COG3469	chitinase activity
GPZ77_RS12445	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS12535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS12540	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPZ77_RS12545	COG0765	amino acid transport
GPZ77_RS12550	COG0765	amino acid transport
GPZ77_RS12555	COG1126	abc transporter atp-binding protein
GPZ77_RS12570	COG2197	response regulator
GPZ77_RS12580	COG0659	secondary active sulfate transmembrane transporter activity
GPZ77_RS12585	COG0288	reversible hydration of carbon dioxide
GPZ77_RS12590	COG3397	chitin binding
GPZ77_RS12630	COG1940	carbohydrate kinase activity
GPZ77_RS12635	COG0673	inositol 2-dehydrogenase activity
GPZ77_RS12640	COG4702	Belongs to the UPF0303 family
GPZ77_RS12650	COG0706	membrane insertase activity
GPZ77_RS12655	COG3764	Sortase (surface protein transpeptidase)
GPZ77_RS12685	COG2733	membrane
GPZ77_RS12690	COG4555	ABC transporter
GPZ77_RS12710	COG2076	Multidrug Resistance protein
GPZ77_RS12740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPZ77_RS12750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPZ77_RS12755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPZ77_RS12755	COG1263	PTS System
GPZ77_RS12760	COG1263	PTS System
GPZ77_RS12760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPZ77_RS12765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPZ77_RS12765	COG1263	PTS System
GPZ77_RS12770	COG1234	tRNA 3'-trailer cleavage
GPZ77_RS12790	COG1120	ATPase activity
GPZ77_RS12795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS12815	COG1113	amino acid transport
GPZ77_RS12825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPZ77_RS12835	COG1335	isochorismatase
GPZ77_RS12845	COG3291	Pkd domain containing protein
GPZ77_RS12845	COG4412	M6 family metalloprotease domain protein
GPZ77_RS12870	COG0277	FAD linked oxidase domain protein
GPZ77_RS12880	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GPZ77_RS12925	COG3654	unkown
GPZ77_RS12970	COG1404	Belongs to the peptidase S8 family
GPZ77_RS12990	COG1404	Belongs to the peptidase S8 family
GPZ77_RS13005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GPZ77_RS13020	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GPZ77_RS13025	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS13045	COG1678	Uncharacterized ACR, COG1678
GPZ77_RS13050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPZ77_RS13055	COG0776	regulation of translation
GPZ77_RS13065	COG3973	AAA domain
GPZ77_RS13100	COG0583	DNA-binding transcription factor activity
GPZ77_RS13115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPZ77_RS13120	COG3409	Peptidoglycan-binding domain 1 protein
GPZ77_RS13120	COG0793	Belongs to the peptidase S41A family
GPZ77_RS13130	COG2884	Cell division ATP-binding protein ftsE
GPZ77_RS13145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GPZ77_RS13150	COG0515	serine threonine protein kinase
GPZ77_RS13155	COG0515	serine threonine protein kinase
GPZ77_RS13180	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS13190	COG2902	Dehydrogenase
GPZ77_RS13220	COG0653	protein targeting
GPZ77_RS13230	COG3214	Protein conserved in bacteria
GPZ77_RS13235	COG2197	response regulator
GPZ77_RS13240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPZ77_RS13250	COG0823	Involved in the tonB-independent uptake of proteins
GPZ77_RS13255	COG5002	protein histidine kinase activity
GPZ77_RS13255	COG5000	phosphorelay sensor kinase activity
GPZ77_RS13260	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS13280	COG0714	Associated with various cellular activities
GPZ77_RS13320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GPZ77_RS13345	COG2835	tetraacyldisaccharide 4'-kinase activity
GPZ77_RS13350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPZ77_RS13395	COG0778	Nitroreductase
GPZ77_RS13395	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GPZ77_RS13435	COG1316	TRANSCRIPTIONal
GPZ77_RS13445	COG1316	TRANSCRIPTIONal
GPZ77_RS13455	COG1216	Glycosyl transferase, family 2
GPZ77_RS13460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GPZ77_RS13465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GPZ77_RS13480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPZ77_RS13495	COG2205	protein histidine kinase activity
GPZ77_RS13500	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS13505	COG3104	oligopeptide transport
GPZ77_RS13535	COG1366	Belongs to the anti-sigma-factor antagonist family
GPZ77_RS13540	COG1191	sigma factor activity
GPZ77_RS13550	COG1794	racemase activity, acting on amino acids and derivatives
GPZ77_RS13560	COG1228	amidohydrolase
GPZ77_RS13575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPZ77_RS13615	COG1737	Transcriptional regulator
GPZ77_RS13635	COG0183	Belongs to the thiolase family
GPZ77_RS13660	COG0789	Transcriptional regulator
GPZ77_RS13680	COG1136	(ABC) transporter
GPZ77_RS13680	COG0577	efflux transmembrane transporter activity
GPZ77_RS13695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPZ77_RS13720	COG0148	phosphopyruvate hydratase activity
GPZ77_RS13735	COG2124	cytochrome p450
GPZ77_RS13755	COG0463	Glycosyl transferase, family 2
GPZ77_RS13900	COG1136	(ABC) transporter
GPZ77_RS13900	COG0577	efflux transmembrane transporter activity
GPZ77_RS13905	COG1136	(ABC) transporter
GPZ77_RS13910	COG0477	Major facilitator Superfamily
GPZ77_RS13945	COG4585	Histidine kinase
GPZ77_RS13960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPZ77_RS13965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPZ77_RS13975	COG0583	DNA-binding transcription factor activity
GPZ77_RS13985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPZ77_RS13990	COG0193	aminoacyl-tRNA hydrolase activity
GPZ77_RS14005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPZ77_RS14015	COG1309	transcriptional regulator
GPZ77_RS14025	COG4106	trans-aconitate 2-methyltransferase activity
GPZ77_RS14030	COG1846	Transcriptional regulator
GPZ77_RS14035	COG2197	response regulator
GPZ77_RS14040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPZ77_RS14075	COG0488	(ABC) transporter
GPZ77_RS14085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPZ77_RS14090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPZ77_RS14095	COG3583	domain protein
GPZ77_RS14095	COG3584	3D domain protein
GPZ77_RS14100	COG0084	hydrolase, TatD family'
GPZ77_RS14150	COG0442	prolyl-tRNA aminoacylation
GPZ77_RS14170	COG1122	ATPase activity
GPZ77_RS14180	COG0310	cobalt ion transport
GPZ77_RS14190	COG2409	Drug exporters of the RND superfamily
GPZ77_RS14200	COG4946	Tricorn protease homolog
GPZ77_RS14200	COG0793	Belongs to the peptidase S41A family
GPZ77_RS14210	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS14215	COG2267	carboxylic ester hydrolase activity
GPZ77_RS14220	COG2072	flavoprotein involved in K transport
GPZ77_RS14230	COG0708	Exodeoxyribonuclease III
GPZ77_RS14260	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPZ77_RS14265	COG0315	cyclic pyranopterin monophosphate synthase activity
GPZ77_RS14275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GPZ77_RS14280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPZ77_RS14310	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPZ77_RS14320	COG1970	mechanosensitive ion channel activity
GPZ77_RS14340	COG3191	aminopeptidase activity
GPZ77_RS14355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPZ77_RS14355	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPZ77_RS14355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPZ77_RS14365	COG1349	DNA-binding transcription factor activity
GPZ77_RS14370	COG0477	Major facilitator Superfamily
GPZ77_RS14385	COG1247	-acetyltransferase
GPZ77_RS14390	COG3384	dioxygenase
GPZ77_RS14395	COG1846	Transcriptional regulator
GPZ77_RS14435	COG0277	FAD linked oxidase domain protein
GPZ77_RS14460	COG1733	regulation of RNA biosynthetic process
GPZ77_RS14470	COG0475	glutathione-regulated potassium exporter activity
GPZ77_RS14500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPZ77_RS14510	COG2814	Major facilitator Superfamily
GPZ77_RS14525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPZ77_RS14545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPZ77_RS14560	COG4770	biotin carboxylase activity
GPZ77_RS14575	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS14600	COG4977	sequence-specific DNA binding
GPZ77_RS14600	COG1917	Cupin 2, conserved barrel domain protein
GPZ77_RS14650	COG1686	Belongs to the peptidase S11 family
GPZ77_RS14675	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS14690	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GPZ77_RS14780	COG5002	protein histidine kinase activity
GPZ77_RS14785	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS14795	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS14810	COG1024	Enoyl-CoA hydratase
GPZ77_RS14830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPZ77_RS14830	COG0515	serine threonine protein kinase
GPZ77_RS14840	COG1309	transcriptional regulator
GPZ77_RS14850	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS14870	COG0259	pyridoxamine-phosphate oxidase activity
GPZ77_RS14890	COG1309	transcriptional regulator
GPZ77_RS14935	COG1301	dicarboxylic acid transport
GPZ77_RS14950	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GPZ77_RS14960	COG0163	prenyltransferase activity
GPZ77_RS14965	COG0109	protoheme IX farnesyltransferase activity
GPZ77_RS14970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPZ77_RS15020	COG1333	cytochrome c biogenesis protein
GPZ77_RS15025	COG0785	Cytochrome C biogenesis protein
GPZ77_RS15030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPZ77_RS15040	COG0406	alpha-ribazole phosphatase activity
GPZ77_RS15045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPZ77_RS15055	COG0789	Transcriptional regulator
GPZ77_RS15100	COG1846	Transcriptional regulator
GPZ77_RS15120	COG1742	UPF0060 membrane protein
GPZ77_RS15130	COG1690	Belongs to the RtcB family
GPZ77_RS15155	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GPZ77_RS15160	COG0018	arginyl-trna synthetase
GPZ77_RS15180	COG0113	porphobilinogen synthase activity
GPZ77_RS15185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPZ77_RS15185	COG1648	precorrin-2 dehydrogenase activity
GPZ77_RS15190	COG0181	hydroxymethylbilane synthase activity
GPZ77_RS15195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPZ77_RS15200	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GPZ77_RS15210	COG0560	Phosphoserine phosphatase
GPZ77_RS15250	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPZ77_RS15255	COG2223	nitrite transmembrane transporter activity
GPZ77_RS15260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPZ77_RS15280	COG0180	Tryptophanyl-tRNA synthetase
GPZ77_RS15285	COG1335	isochorismatase
GPZ77_RS15290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPZ77_RS15300	COG1129	ABC transporter
GPZ77_RS15300	COG0842	Transport permease protein
GPZ77_RS15315	COG0515	serine threonine protein kinase
GPZ77_RS15315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPZ77_RS15320	COG0129	dihydroxy-acid dehydratase activity
GPZ77_RS15330	COG1082	Xylose isomerase domain protein TIM barrel
GPZ77_RS15335	COG0248	Ppx GppA phosphatase
GPZ77_RS15355	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GPZ77_RS15365	COG0671	phosphoesterase, PA-phosphatase related
GPZ77_RS15375	COG1595	DNA-templated transcription, initiation
GPZ77_RS15385	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS15390	COG2205	protein histidine kinase activity
GPZ77_RS15405	COG0739	heme binding
GPZ77_RS15425	COG0542	response to heat
GPZ77_RS15440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPZ77_RS15455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GPZ77_RS15465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPZ77_RS15470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPZ77_RS15490	COG0640	Transcriptional regulator
GPZ77_RS15495	COG2197	response regulator
GPZ77_RS15510	COG0649	NAD binding
GPZ77_RS15525	COG1732	Glycine betaine
GPZ77_RS15530	COG1174	glycine betaine transport
GPZ77_RS15535	COG1174	glycine betaine transport
GPZ77_RS15550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPZ77_RS15550	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GPZ77_RS15565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPZ77_RS15585	COG0302	gtp cyclohydrolase
GPZ77_RS15600	COG0037	tRNA processing
GPZ77_RS15615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPZ77_RS15625	COG0586	Pfam SNARE associated Golgi protein
GPZ77_RS15630	COG0393	Putative heavy-metal-binding
GPZ77_RS15640	COG0076	glutamate decarboxylase activity
GPZ77_RS15660	COG2318	DinB family
GPZ77_RS15665	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS15685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPZ77_RS15695	COG0254	rRNA binding
GPZ77_RS15700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPZ77_RS15705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPZ77_RS15710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPZ77_RS15730	COG1136	(ABC) transporter
GPZ77_RS15745	COG2197	response regulator
GPZ77_RS15750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPZ77_RS15750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPZ77_RS15795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPZ77_RS15800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPZ77_RS15800	COG1754	DNA topoisomerase type I activity
GPZ77_RS15820	COG2890	protein-(glutamine-N5) methyltransferase activity
GPZ77_RS15830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GPZ77_RS15840	COG1366	Belongs to the anti-sigma-factor antagonist family
GPZ77_RS15845	COG1111	helicase
GPZ77_RS15845	COG1205	dead DEAH box helicase
GPZ77_RS15905	COG0288	reversible hydration of carbon dioxide
GPZ77_RS15910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPZ77_RS15915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPZ77_RS15925	COG2267	carboxylic ester hydrolase activity
GPZ77_RS15960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPZ77_RS15985	COG0003	Pfam Anion-transporting ATPase
GPZ77_RS16000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPZ77_RS16010	COG1408	metallophosphoesterase
GPZ77_RS16020	COG0659	secondary active sulfate transmembrane transporter activity
GPZ77_RS16035	COG2815	serine threonine protein kinase
GPZ77_RS16035	COG0515	serine threonine protein kinase
GPZ77_RS16060	COG1595	DNA-templated transcription, initiation
GPZ77_RS16080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPZ77_RS16085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPZ77_RS16100	COG1802	Transcriptional regulator
GPZ77_RS16105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPZ77_RS16110	COG0693	protein deglycase activity
GPZ77_RS16145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPZ77_RS16170	COG0583	DNA-binding transcription factor activity
GPZ77_RS16175	COG0300	oxidoreductase activity
GPZ77_RS16180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPZ77_RS16190	COG2124	cytochrome p450
GPZ77_RS16195	COG2197	response regulator
GPZ77_RS16200	COG4585	Histidine kinase
GPZ77_RS16215	COG3844	kynureninase activity
GPZ77_RS16235	COG0477	Major facilitator Superfamily
GPZ77_RS16240	COG0191	fructose-bisphosphate aldolase activity
GPZ77_RS16245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPZ77_RS16260	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GPZ77_RS16295	COG0542	response to heat
GPZ77_RS16320	COG0789	Transcriptional regulator
GPZ77_RS16325	COG0484	heat shock protein binding
GPZ77_RS16330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPZ77_RS16335	COG0443	Heat shock 70 kDa protein
GPZ77_RS16345	COG0247	lactate metabolic process
GPZ77_RS16345	COG2181	nitrate reductase activity
GPZ77_RS16360	COG0717	Belongs to the dCTP deaminase family
GPZ77_RS16395	COG2311	Membrane
GPZ77_RS16415	COG3693	PFAM glycoside hydrolase, family 10
GPZ77_RS16465	COG1231	oxidoreductase activity
GPZ77_RS16480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPZ77_RS16485	COG1957	nucleoside hydrolase
GPZ77_RS16490	COG0488	(ABC) transporter
GPZ77_RS16530	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GPZ77_RS16555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS16595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS16600	COG2267	carboxylic ester hydrolase activity
GPZ77_RS16625	COG1289	transmembrane transporter activity
GPZ77_RS16655	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS16660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPZ77_RS16695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPZ77_RS16715	COG1741	Belongs to the pirin family
GPZ77_RS16740	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS16745	COG1362	aminopeptidase activity
GPZ77_RS16770	COG0626	cystathionine gamma-synthase activity
GPZ77_RS16775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS16790	COG2271	Major facilitator Superfamily
GPZ77_RS16800	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPZ77_RS16805	COG0022	dehydrogenase e1 component
GPZ77_RS16825	COG0515	serine threonine protein kinase
GPZ77_RS16830	COG0515	serine threonine protein kinase
GPZ77_RS16840	COG1136	(ABC) transporter
GPZ77_RS16840	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPZ77_RS16860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPZ77_RS16865	COG0303	'Molybdopterin
GPZ77_RS16870	COG0746	molybdenum cofactor guanylyltransferase activity
GPZ77_RS16890	COG1522	sequence-specific DNA binding
GPZ77_RS16900	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPZ77_RS16925	COG3396	Phenylacetate-CoA oxygenase
GPZ77_RS16930	COG3460	Phenylacetate-CoA oxygenase
GPZ77_RS16935	COG3396	Phenylacetate-CoA oxygenase
GPZ77_RS16940	COG2151	metal-sulfur cluster biosynthetic enzyme
GPZ77_RS16945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPZ77_RS16950	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS16955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPZ77_RS16980	COG2197	response regulator
GPZ77_RS16985	COG4585	Histidine kinase
GPZ77_RS16995	COG1716	ATPase activity
GPZ77_RS17000	COG1716	ATPase activity
GPZ77_RS17015	COG0768	penicillin binding
GPZ77_RS17020	COG0515	serine threonine protein kinase
GPZ77_RS17025	COG3764	Sortase (surface protein transpeptidase)
GPZ77_RS17040	COG3764	Sortase (surface protein transpeptidase)
GPZ77_RS17055	COG0705	Rhomboid family
GPZ77_RS17080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPZ77_RS17185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GPZ77_RS17210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPZ77_RS17230	COG2197	response regulator
GPZ77_RS17250	COG0515	serine threonine protein kinase
GPZ77_RS17275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPZ77_RS17290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPZ77_RS17295	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GPZ77_RS17300	COG0592	DNA-directed DNA polymerase activity
GPZ77_RS17320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPZ77_RS17325	COG0706	membrane insertase activity
GPZ77_RS17335	COG0357	Ribosomal RNA small subunit methyltransferase G
GPZ77_RS17340	COG1192	Involved in chromosome partitioning
GPZ77_RS17355	COG3118	belongs to the thioredoxin family
GPZ77_RS17360	COG0492	ferredoxin-NADP+ reductase activity
GPZ77_RS17370	COG1595	DNA-templated transcription, initiation
GPZ77_RS17390	COG0617	tRNA 3'-terminal CCA addition
GPZ77_RS17410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPZ77_RS17435	COG0360	Binds together with S18 to 16S ribosomal RNA
GPZ77_RS17440	COG0629	single-stranded DNA binding
GPZ77_RS17445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPZ77_RS17450	COG0359	binds to the 23S rRNA
GPZ77_RS17460	COG0305	Participates in initiation and elongation during chromosome replication
GPZ77_RS17500	COG0494	nUDIX hydrolase
GPZ77_RS17510	COG0626	cystathionine gamma-synthase activity
GPZ77_RS17515	COG1950	PFAM Membrane protein of
GPZ77_RS17520	COG0662	Cupin 2, conserved barrel domain protein
GPZ77_RS17545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPZ77_RS17555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPZ77_RS17560	COG1609	Transcriptional regulator
GPZ77_RS17565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPZ77_RS17575	COG1271	oxidase subunit
GPZ77_RS17580	COG1294	oxidase, subunit
GPZ77_RS17585	COG4988	ABC transporter
GPZ77_RS17595	COG0561	phosphatase activity
GPZ77_RS17605	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GPZ77_RS17610	COG0789	Transcriptional regulator
GPZ77_RS17625	COG1131	(ABC) transporter
GPZ77_RS17650	COG2186	Transcriptional regulator
GPZ77_RS17670	COG0561	phosphatase activity
GPZ77_RS17675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPZ77_RS17685	COG2837	iron assimilation
GPZ77_RS17700	COG1999	signal sequence binding
GPZ77_RS17720	COG0006	proline dipeptidase activity
GPZ77_RS17740	COG0653	protein targeting
GPZ77_RS17840	COG2188	Transcriptional regulator
GPZ77_RS17845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPZ77_RS17865	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS17875	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS17895	COG1595	DNA-templated transcription, initiation
GPZ77_RS17905	COG0784	Response regulator, receiver
GPZ77_RS17955	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS17960	COG2205	protein histidine kinase activity
GPZ77_RS17970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPZ77_RS17975	COG0477	Major facilitator Superfamily
GPZ77_RS17985	COG2353	YceI-like domain
GPZ77_RS17995	COG1846	Transcriptional regulator
GPZ77_RS18015	COG1191	sigma factor activity
GPZ77_RS18020	COG1191	sigma factor activity
GPZ77_RS18050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPZ77_RS18065	COG0433	COG0433 Predicted ATPase
GPZ77_RS18080	COG2267	carboxylic ester hydrolase activity
GPZ77_RS18090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPZ77_RS18105	COG0655	NAD(P)H dehydrogenase (quinone) activity
GPZ77_RS18130	COG4941	Belongs to the sigma-70 factor family
GPZ77_RS18145	COG0667	Aldo Keto reductase
GPZ77_RS18155	COG1136	(ABC) transporter
GPZ77_RS18195	COG0151	Belongs to the GarS family
GPZ77_RS18210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPZ77_RS18220	COG2197	response regulator
GPZ77_RS18225	COG3851	Histidine kinase
GPZ77_RS18255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPZ77_RS18260	COG0047	phosphoribosylformylglycinamidine synthase activity
GPZ77_RS18265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPZ77_RS18285	COG3119	arylsulfatase activity
GPZ77_RS18295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPZ77_RS18305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPZ77_RS18330	COG1643	Atp-dependent helicase
GPZ77_RS18340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPZ77_RS18340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPZ77_RS18345	COG0785	Cytochrome C biogenesis protein
GPZ77_RS18375	COG0513	Belongs to the DEAD box helicase family
GPZ77_RS18390	COG1595	DNA-templated transcription, initiation
GPZ77_RS18405	COG0789	Transcriptional regulator
GPZ77_RS18420	COG0667	Aldo Keto reductase
GPZ77_RS18430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPZ77_RS18435	COG0579	oxidoreductase
GPZ77_RS18455	COG1470	cell adhesion involved in biofilm formation
GPZ77_RS18455	COG0366	Alpha amylase catalytic
GPZ77_RS18465	COG1252	NADH dehydrogenase
GPZ77_RS18480	COG1846	Transcriptional regulator
GPZ77_RS18500	COG2197	response regulator
GPZ77_RS18505	COG4585	Histidine kinase
GPZ77_RS18515	COG1131	(ABC) transporter
GPZ77_RS18560	COG1309	transcriptional regulator
GPZ77_RS18575	COG0671	phosphoesterase, PA-phosphatase related
GPZ77_RS18590	COG1937	Protein conserved in bacteria
GPZ77_RS18600	COG0306	phosphate transporter
GPZ77_RS18605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPZ77_RS18620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPZ77_RS18640	COG0531	amino acid
GPZ77_RS18645	COG2264	protein methyltransferase activity
GPZ77_RS18675	COG1725	Transcriptional regulator
GPZ77_RS18680	COG0456	acetyltransferase
GPZ77_RS18685	COG0737	Belongs to the 5'-nucleotidase family
GPZ77_RS18690	COG0823	Involved in the tonB-independent uptake of proteins
GPZ77_RS18705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPZ77_RS18710	COG1609	Transcriptional regulator
GPZ77_RS18715	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS18775	COG3485	protocatechuate 3,4-dioxygenase
GPZ77_RS18785	COG0354	folic acid binding
GPZ77_RS18790	COG1490	D-aminoacyl-tRNA deacylase activity
GPZ77_RS18800	COG4552	Acetyltransferase involved in intracellular survival and related
GPZ77_RS18825	COG3973	AAA domain
GPZ77_RS18830	COG0583	DNA-binding transcription factor activity
GPZ77_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS18875	COG1309	transcriptional regulator
GPZ77_RS18910	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS18930	COG0588	phosphoglycerate mutase activity
GPZ77_RS18945	COG5002	protein histidine kinase activity
GPZ77_RS18965	COG1329	Transcriptional regulator
GPZ77_RS18970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPZ77_RS18975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPZ77_RS18980	COG0215	cysteine-tRNA ligase activity
GPZ77_RS18995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPZ77_RS19005	COG3842	ATPase activity
GPZ77_RS19060	COG2197	response regulator
GPZ77_RS19085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GPZ77_RS19145	COG0463	Glycosyl transferase, family 2
GPZ77_RS19205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPZ77_RS19210	COG1737	Transcriptional regulator
GPZ77_RS19300	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS19315	COG3973	AAA domain
GPZ77_RS19320	COG1061	Type III restriction enzyme res subunit
GPZ77_RS19340	COG1120	ATPase activity
GPZ77_RS19345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS19350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS19365	COG1278	Cold shock
GPZ77_RS19370	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GPZ77_RS19375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPZ77_RS19385	COG2814	Major facilitator Superfamily
GPZ77_RS19400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GPZ77_RS19410	COG2252	PERMEase
GPZ77_RS19445	COG0667	Aldo Keto reductase
GPZ77_RS19500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPZ77_RS19505	COG0277	FAD linked oxidase domain protein
GPZ77_RS19515	COG0583	DNA-binding transcription factor activity
GPZ77_RS19540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPZ77_RS19555	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS19580	COG0259	pyridoxamine-phosphate oxidase activity
GPZ77_RS19595	COG4555	ABC transporter
GPZ77_RS19620	COG4821	SIS domain
GPZ77_RS19630	COG2945	thiolester hydrolase activity
GPZ77_RS19630	COG0596	Alpha beta hydrolase
GPZ77_RS19675	COG3973	AAA domain
GPZ77_RS19685	COG0535	radical SAM domain protein
GPZ77_RS19705	COG4555	ABC transporter
GPZ77_RS19750	COG1366	Belongs to the anti-sigma-factor antagonist family
GPZ77_RS19760	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS19770	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS19775	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS19790	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS19820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPZ77_RS19830	COG1024	Enoyl-CoA hydratase
GPZ77_RS19835	COG1042	CoA-binding domain protein
GPZ77_RS19835	COG0045	succinate-CoA ligase (ADP-forming) activity
GPZ77_RS19835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPZ77_RS19840	COG0823	Involved in the tonB-independent uptake of proteins
GPZ77_RS19845	COG2072	flavoprotein involved in K transport
GPZ77_RS19860	COG0515	serine threonine protein kinase
GPZ77_RS19860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPZ77_RS19865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPZ77_RS19915	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GPZ77_RS19930	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GPZ77_RS19940	COG2226	methyltransferase
GPZ77_RS19955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPZ77_RS19970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPZ77_RS19975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPZ77_RS19980	COG0649	NAD binding
GPZ77_RS19990	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GPZ77_RS19995	COG1034	ATP synthesis coupled electron transport
GPZ77_RS20000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GPZ77_RS20005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPZ77_RS20010	COG0839	Belongs to the complex I subunit 6 family
GPZ77_RS20015	COG0713	ATP synthesis coupled electron transport
GPZ77_RS20020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPZ77_RS20030	COG1007	ATP synthesis coupled electron transport
GPZ77_RS20040	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPZ77_RS20090	COG1733	regulation of RNA biosynthetic process
GPZ77_RS20115	COG0702	epimerase
GPZ77_RS20120	COG1733	regulation of RNA biosynthetic process
GPZ77_RS20130	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPZ77_RS20130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPZ77_RS20145	COG4585	Histidine kinase
GPZ77_RS20150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPZ77_RS20155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPZ77_RS20160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPZ77_RS20165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GPZ77_RS20170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPZ77_RS20175	COG0839	Belongs to the complex I subunit 6 family
GPZ77_RS20180	COG0713	ATP synthesis coupled electron transport
GPZ77_RS20195	COG1007	ATP synthesis coupled electron transport
GPZ77_RS20200	COG0501	Belongs to the peptidase M48B family
GPZ77_RS20205	COG3304	Inner membrane component domain
GPZ77_RS20215	COG2261	transglycosylase associated protein
GPZ77_RS20225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPZ77_RS20230	COG1666	GTP binding
GPZ77_RS20325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPZ77_RS20330	COG2186	Transcriptional regulator
GPZ77_RS20340	COG0702	epimerase
GPZ77_RS20360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPZ77_RS20365	COG2030	dehydratase
GPZ77_RS20380	COG0477	Major facilitator Superfamily
GPZ77_RS20385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPZ77_RS20405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPZ77_RS20410	COG0436	Aminotransferase
GPZ77_RS20420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPZ77_RS20430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPZ77_RS20435	COG0081	regulation of translation
GPZ77_RS20440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPZ77_RS20445	COG0222	ribosome binding
GPZ77_RS20450	COG0085	RNA polymerase activity
GPZ77_RS20455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPZ77_RS20575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPZ77_RS20585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPZ77_RS20590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPZ77_RS20650	COG0051	transcription antitermination factor activity, RNA binding
GPZ77_RS20655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPZ77_RS20660	COG0088	Forms part of the polypeptide exit tunnel
GPZ77_RS20665	COG0089	rRNA binding
GPZ77_RS20670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPZ77_RS20675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPZ77_RS20680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPZ77_RS20685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPZ77_RS20690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPZ77_RS20695	COG0255	Belongs to the universal ribosomal protein uL29 family
GPZ77_RS20700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPZ77_RS20705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPZ77_RS20710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPZ77_RS20715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPZ77_RS20720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPZ77_RS20730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPZ77_RS20735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPZ77_RS20740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPZ77_RS20745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPZ77_RS20750	COG1841	ribosomal large subunit assembly
GPZ77_RS20755	COG0200	Binds to the 23S rRNA
GPZ77_RS20765	COG0563	adenylate kinase activity
GPZ77_RS20775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPZ77_RS20780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPZ77_RS20785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPZ77_RS20790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPZ77_RS20795	COG0202	RNA polymerase activity
GPZ77_RS20800	COG0203	ribosomal protein L17
GPZ77_RS20805	COG0101	tRNA pseudouridine synthase activity
GPZ77_RS20815	COG0488	(ABC) transporter
GPZ77_RS20825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPZ77_RS20830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPZ77_RS20840	COG1072	(Pantothenic acid kinase))
GPZ77_RS20850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPZ77_RS20855	COG0736	holo-[acyl-carrier-protein] synthase activity
GPZ77_RS20875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPZ77_RS20885	COG0802	atpase or kinase
GPZ77_RS20905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPZ77_RS20915	COG0726	polysaccharide deacetylase
GPZ77_RS20925	COG4941	Belongs to the sigma-70 factor family
GPZ77_RS20950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPZ77_RS20965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPZ77_RS20975	COG1175	transmembrane transport
GPZ77_RS20995	COG4221	oxidoreductase activity
GPZ77_RS21005	COG0583	DNA-binding transcription factor activity
GPZ77_RS21020	COG1595	DNA-templated transcription, initiation
GPZ77_RS21030	COG0516	GMP reductase activity
GPZ77_RS21040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPZ77_RS21055	COG0515	serine threonine protein kinase
GPZ77_RS21060	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS21075	COG0519	Catalyzes the synthesis of GMP from XMP
GPZ77_RS21075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPZ77_RS21110	COG2197	response regulator
GPZ77_RS21135	COG0739	heme binding
GPZ77_RS21145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GPZ77_RS21165	COG0714	Associated with various cellular activities
GPZ77_RS21175	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GPZ77_RS21180	COG0045	succinate-CoA ligase (ADP-forming) activity
GPZ77_RS21210	COG0138	bifunctional purine biosynthesis protein purh
GPZ77_RS21215	COG0577	efflux transmembrane transporter activity
GPZ77_RS21220	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPZ77_RS21220	COG1136	(ABC) transporter
GPZ77_RS21250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPZ77_RS21260	COG0039	L-malate dehydrogenase activity
GPZ77_RS21265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPZ77_RS21270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPZ77_RS21280	COG0754	glutathionylspermidine amidase activity
GPZ77_RS21285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPZ77_RS21290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPZ77_RS21300	COG0180	Tryptophanyl-tRNA synthetase
GPZ77_RS21320	COG0671	phosphoesterase, PA-phosphatase related
GPZ77_RS21330	COG1295	ribonuclease BN
GPZ77_RS21345	COG1408	metallophosphoesterase
GPZ77_RS21350	COG0747	negative chemotaxis
GPZ77_RS21390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPZ77_RS21395	COG1053	succinate dehydrogenase
GPZ77_RS21405	COG2009	succinate dehydrogenase
GPZ77_RS21415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GPZ77_RS21455	COG1595	DNA-templated transcription, initiation
GPZ77_RS21470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GPZ77_RS21470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GPZ77_RS21480	COG0789	Transcriptional regulator
GPZ77_RS21490	COG1216	Glycosyl transferase, family 2
GPZ77_RS21500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPZ77_RS21505	COG2089	acid synthase
GPZ77_RS21515	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GPZ77_RS21515	COG1473	amidohydrolase
GPZ77_RS21550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPZ77_RS21570	COG2814	Major facilitator Superfamily
GPZ77_RS21575	COG0583	DNA-binding transcription factor activity
GPZ77_RS21610	COG2205	protein histidine kinase activity
GPZ77_RS21615	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS21620	COG1595	DNA-templated transcription, initiation
GPZ77_RS21635	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS21640	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS21660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPZ77_RS21690	COG4770	biotin carboxylase activity
GPZ77_RS21700	COG0424	maF-like protein
GPZ77_RS21720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPZ77_RS21735	COG1024	Enoyl-CoA hydratase
GPZ77_RS21745	COG2986	histidine ammonia-lyase
GPZ77_RS21770	COG1064	alcohol dehydrogenase
GPZ77_RS21780	COG0488	(ABC) transporter
GPZ77_RS21785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPZ77_RS21810	COG1595	DNA-templated transcription, initiation
GPZ77_RS21820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GPZ77_RS21835	COG0515	serine threonine protein kinase
GPZ77_RS21835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPZ77_RS21840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPZ77_RS21840	COG0515	serine threonine protein kinase
GPZ77_RS21845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPZ77_RS21855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GPZ77_RS21875	COG1331	Highly conserved protein containing a thioredoxin domain
GPZ77_RS21880	COG1316	TRANSCRIPTIONal
GPZ77_RS21905	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS21930	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS21960	COG2304	oxidoreductase activity
GPZ77_RS21995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GPZ77_RS22020	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GPZ77_RS22035	COG1414	Transcriptional regulator
GPZ77_RS22040	COG0251	oxidation-reduction process
GPZ77_RS22055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPZ77_RS22055	COG0515	serine threonine protein kinase
GPZ77_RS22085	COG2894	cell division
GPZ77_RS22115	COG3920	Histidine kinase
GPZ77_RS22120	COG2197	response regulator
GPZ77_RS22155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GPZ77_RS22170	COG1733	regulation of RNA biosynthetic process
GPZ77_RS22175	COG0667	Aldo Keto reductase
GPZ77_RS22180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPZ77_RS22185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPZ77_RS22205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPZ77_RS22210	COG0450	alkyl hydroperoxide reductase
GPZ77_RS22225	COG1136	(ABC) transporter
GPZ77_RS22235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPZ77_RS22250	COG0114	fumarate hydratase activity
GPZ77_RS22270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GPZ77_RS22270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GPZ77_RS22295	COG0778	Nitroreductase
GPZ77_RS22300	COG1722	exodeoxyribonuclease VII activity
GPZ77_RS22305	COG1570	exodeoxyribonuclease VII activity
GPZ77_RS22315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPZ77_RS22330	COG0012	GTP binding
GPZ77_RS22365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPZ77_RS22375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPZ77_RS22380	COG1024	Enoyl-CoA hydratase
GPZ77_RS22410	COG2197	response regulator
GPZ77_RS22430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPZ77_RS22435	COG0189	ligase activity
GPZ77_RS22460	COG3959	Transketolase, thiamine diphosphate binding domain
GPZ77_RS22465	COG3958	Transketolase
GPZ77_RS22475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPZ77_RS22480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPZ77_RS22485	COG0529	Catalyzes the synthesis of activated sulfate
GPZ77_RS22525	COG3629	intracellular signal transduction
GPZ77_RS22525	COG3903	Transcriptional regulator
GPZ77_RS22540	COG3866	Pectate lyase
GPZ77_RS22545	COG1185	polyribonucleotide nucleotidyltransferase activity
GPZ77_RS22565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPZ77_RS22610	COG1842	Phage shock protein A
GPZ77_RS22630	COG1053	succinate dehydrogenase
GPZ77_RS22655	COG0747	negative chemotaxis
GPZ77_RS22660	COG0601	transmembrane transport
GPZ77_RS22665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPZ77_RS22670	COG0444	Belongs to the ABC transporter superfamily
GPZ77_RS22675	COG4608	Belongs to the ABC transporter superfamily
GPZ77_RS22685	COG0601	transmembrane transport
GPZ77_RS22690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPZ77_RS22695	COG0444	Belongs to the ABC transporter superfamily
GPZ77_RS22700	COG4608	Belongs to the ABC transporter superfamily
GPZ77_RS22720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GPZ77_RS22790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPZ77_RS22795	COG1611	Belongs to the LOG family
GPZ77_RS22800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPZ77_RS22810	COG0519	Catalyzes the synthesis of GMP from XMP
GPZ77_RS22815	COG1024	Enoyl-CoA hydratase
GPZ77_RS22830	COG1595	DNA-templated transcription, initiation
GPZ77_RS22845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPZ77_RS22880	COG0598	Magnesium transport protein CorA
GPZ77_RS22900	COG2095	MarC family integral membrane protein
GPZ77_RS22910	COG1432	Conserved Protein
GPZ77_RS22915	COG0596	Alpha beta hydrolase
GPZ77_RS22920	COG0513	Belongs to the DEAD box helicase family
GPZ77_RS22950	COG0596	Alpha beta hydrolase
GPZ77_RS23020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPZ77_RS23030	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GPZ77_RS23065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPZ77_RS23120	COG3480	Lon protease (S16) C-terminal proteolytic domain
GPZ77_RS23155	COG0753	catalase activity
GPZ77_RS23165	COG0483	inositol monophosphate 1-phosphatase activity
GPZ77_RS23175	COG2076	Multidrug Resistance protein
GPZ77_RS23185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPZ77_RS23195	COG2135	peptidase activity
GPZ77_RS23205	COG1595	DNA-templated transcription, initiation
GPZ77_RS23210	COG5662	AntiSigma factor
GPZ77_RS23230	COG0242	peptide deformylase activity
GPZ77_RS23235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPZ77_RS23255	COG1966	Carbon starvation protein
GPZ77_RS23260	COG2188	Transcriptional regulator
GPZ77_RS23280	COG1472	Belongs to the glycosyl hydrolase 3 family
GPZ77_RS23285	COG0363	glucosamine-6-phosphate deaminase activity
GPZ77_RS23290	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS23310	COG1597	lipid kinase activity
GPZ77_RS23340	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GPZ77_RS23350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPZ77_RS23410	COG4106	trans-aconitate 2-methyltransferase activity
GPZ77_RS23415	COG1126	abc transporter atp-binding protein
GPZ77_RS23420	COG0765	amino acid transport
GPZ77_RS23425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ77_RS23435	COG0604	alcohol dehydrogenase
GPZ77_RS23440	COG1874	Beta-galactosidase
GPZ77_RS23465	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPZ77_RS23465	COG0567	Dehydrogenase, E1 component
GPZ77_RS23475	COG2205	protein histidine kinase activity
GPZ77_RS23480	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS23510	COG1595	DNA-templated transcription, initiation
GPZ77_RS23520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPZ77_RS23530	COG1846	Transcriptional regulator
GPZ77_RS23540	COG5002	protein histidine kinase activity
GPZ77_RS23600	COG0768	penicillin binding
GPZ77_RS23620	COG1793	dna ligase
GPZ77_RS23625	COG3285	dna ligase
GPZ77_RS23625	COG1793	dna ligase
GPZ77_RS23630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GPZ77_RS23645	COG1309	transcriptional regulator
GPZ77_RS23650	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS23655	COG2076	Multidrug Resistance protein
GPZ77_RS23670	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS23680	COG1465	3-dehydroquinate synthase
GPZ77_RS23685	COG1830	Aldolase
GPZ77_RS23745	COG0720	synthase
GPZ77_RS23750	COG0602	queuosine metabolic process
GPZ77_RS23755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPZ77_RS23780	COG3328	transposase activity
GPZ77_RS23795	COG0514	ATP-dependent DNA helicase (RecQ)
GPZ77_RS23865	COG0018	arginyl-trna synthetase
GPZ77_RS23870	COG0019	diaminopimelate decarboxylase activity
GPZ77_RS23875	COG0460	homoserine dehydrogenase
GPZ77_RS23880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPZ77_RS23885	COG0083	homoserine kinase activity
GPZ77_RS23895	COG1316	TRANSCRIPTIONal
GPZ77_RS23900	COG0254	rRNA binding
GPZ77_RS23905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPZ77_RS23910	COG2890	protein-(glutamine-N5) methyltransferase activity
GPZ77_RS23920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPZ77_RS23925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPZ77_RS23945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPZ77_RS23950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPZ77_RS23955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPZ77_RS23960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPZ77_RS23965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPZ77_RS23970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPZ77_RS23975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPZ77_RS23990	COG2197	response regulator
GPZ77_RS23995	COG3850	Histidine kinase
GPZ77_RS24015	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPZ77_RS24030	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GPZ77_RS24085	COG0183	Belongs to the thiolase family
GPZ77_RS24190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPZ77_RS24195	COG0280	phosphate acetyltransferase
GPZ77_RS24195	COG0857	belongs to the CobB CobQ family
GPZ77_RS24200	COG0205	6-phosphofructokinase activity
GPZ77_RS24220	COG4565	transcriptional regulatory protein
GPZ77_RS24225	COG3290	protein histidine kinase activity
GPZ77_RS24230	COG1301	dicarboxylic acid transport
GPZ77_RS24250	COG1522	sequence-specific DNA binding
GPZ77_RS24270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPZ77_RS24285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPZ77_RS24295	COG0366	Alpha amylase catalytic
GPZ77_RS24300	COG0366	Alpha amylase catalytic
GPZ77_RS24345	COG2197	response regulator
GPZ77_RS24365	COG1132	(ABC) transporter
GPZ77_RS24370	COG1132	(ABC) transporter
GPZ77_RS24375	COG1131	(ABC) transporter
GPZ77_RS24385	COG4585	Histidine kinase
GPZ77_RS24390	COG2197	response regulator
GPZ77_RS24445	COG1760	l-serine dehydratase
GPZ77_RS24450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPZ77_RS24455	COG0509	glycine decarboxylation via glycine cleavage system
GPZ77_RS24460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPZ77_RS24480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPZ77_RS24495	COG0444	Belongs to the ABC transporter superfamily
GPZ77_RS24500	COG4608	Belongs to the ABC transporter superfamily
GPZ77_RS24505	COG2860	membrane
GPZ77_RS24555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPZ77_RS24560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPZ77_RS24565	COG1834	amidinotransferase
GPZ77_RS24580	COG0475	glutathione-regulated potassium exporter activity
GPZ77_RS24585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPZ77_RS24605	COG4977	sequence-specific DNA binding
GPZ77_RS24610	COG0531	amino acid
GPZ77_RS24645	COG0482	sulfurtransferase activity
GPZ77_RS24655	COG4221	oxidoreductase activity
GPZ77_RS24665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPZ77_RS24675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GPZ77_RS24680	COG0154	amidase activity
GPZ77_RS24690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GPZ77_RS24725	COG2409	Drug exporters of the RND superfamily
GPZ77_RS24730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPZ77_RS24745	COG2197	response regulator
GPZ77_RS24755	COG2133	pyrroloquinoline quinone binding
GPZ77_RS24760	COG0667	Aldo Keto reductase
GPZ77_RS24770	COG3300	MHYT domain
GPZ77_RS24770	COG5001	Diguanylate cyclase
GPZ77_RS24780	COG0440	acetolactate synthase activity
GPZ77_RS24785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPZ77_RS24790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPZ77_RS24800	COG3903	Transcriptional regulator
GPZ77_RS24800	COG3629	intracellular signal transduction
GPZ77_RS24810	COG0506	proline dehydrogenase activity
GPZ77_RS24815	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS24835	COG0583	DNA-binding transcription factor activity
GPZ77_RS24845	COG0473	3-isopropylmalate dehydrogenase activity
GPZ77_RS24850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPZ77_RS24860	COG0831	urea catabolic process
GPZ77_RS24860	COG0832	Belongs to the urease beta subunit family
GPZ77_RS24865	COG0804	urea catabolic process
GPZ77_RS24870	COG2957	Belongs to the agmatine deiminase family
GPZ77_RS24885	COG0477	Major facilitator Superfamily
GPZ77_RS24900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPZ77_RS24910	COG0592	DNA-directed DNA polymerase activity
GPZ77_RS24940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPZ77_RS24960	COG2018	Roadblock/LC7 domain
GPZ77_RS24980	COG2018	Roadblock/LC7 domain
GPZ77_RS24985	COG5002	protein histidine kinase activity
GPZ77_RS24995	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPZ77_RS25000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPZ77_RS25035	COG1414	Transcriptional regulator
GPZ77_RS25040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPZ77_RS25045	COG0066	3-isopropylmalate dehydratase activity
GPZ77_RS25055	COG0776	regulation of translation
GPZ77_RS25075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPZ77_RS25080	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPZ77_RS25100	COG0351	phosphomethylpyrimidine kinase
GPZ77_RS25105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPZ77_RS25110	COG1461	Dihydroxyacetone kinase
GPZ77_RS25115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPZ77_RS25120	COG0742	ribosomal rna small subunit methyltransferase
GPZ77_RS25125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPZ77_RS25140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPZ77_RS25145	COG0571	ribonuclease III activity
GPZ77_RS25150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPZ77_RS25155	COG1733	regulation of RNA biosynthetic process
GPZ77_RS25160	COG0655	NAD(P)H dehydrogenase (quinone) activity
GPZ77_RS25165	COG2340	Cysteine-rich secretory protein family
GPZ77_RS25170	COG1254	Belongs to the acylphosphatase family
GPZ77_RS25180	COG1196	nuclear chromosome segregation
GPZ77_RS25185	COG0477	Major facilitator Superfamily
GPZ77_RS25195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPZ77_RS25225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPZ77_RS25235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPZ77_RS25250	COG0228	four-way junction DNA binding
GPZ77_RS25255	COG1837	Belongs to the UPF0109 family
GPZ77_RS25260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPZ77_RS25265	COG0336	Belongs to the RNA methyltransferase TrmD family
GPZ77_RS25270	COG0335	large ribosomal subunit rRNA binding
GPZ77_RS25290	COG0681	Belongs to the peptidase S26 family
GPZ77_RS25295	COG1051	belongs to the nudix hydrolase family
GPZ77_RS25305	COG0792	nuclease activity
GPZ77_RS25310	COG0606	chelatase, subunit chli
GPZ77_RS25320	COG1191	sigma factor activity
GPZ77_RS25335	COG0052	Belongs to the universal ribosomal protein uS2 family
GPZ77_RS25340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPZ77_RS25345	COG0528	UMP kinase activity
GPZ77_RS25350	COG0233	cytoplasmic translational termination
GPZ77_RS25380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPZ77_RS25395	COG3842	ATPase activity
GPZ77_RS25415	COG4181	ATPase activity
GPZ77_RS25420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPZ77_RS25430	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS25445	COG2197	response regulator
GPZ77_RS25470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPZ77_RS25495	COG3842	ATPase activity
GPZ77_RS25500	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPZ77_RS25505	COG1177	transmembrane transport
GPZ77_RS25510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPZ77_RS25545	COG0697	spore germination
GPZ77_RS25550	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS25565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPZ77_RS25570	COG0750	zinc metalloprotease
GPZ77_RS25575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPZ77_RS25590	COG0442	prolyl-tRNA aminoacylation
GPZ77_RS25615	COG0779	Required for maturation of 30S ribosomal subunits
GPZ77_RS25630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPZ77_RS25640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPZ77_RS25645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPZ77_RS25660	COG2124	cytochrome p450
GPZ77_RS25665	COG3424	synthase
GPZ77_RS25675	COG4608	Belongs to the ABC transporter superfamily
GPZ77_RS25680	COG0444	Belongs to the ABC transporter superfamily
GPZ77_RS25685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPZ77_RS25690	COG0601	transmembrane transport
GPZ77_RS25700	COG0455	bacterial-type flagellum organization
GPZ77_RS25715	COG3266	domain, Protein
GPZ77_RS25720	COG1404	Belongs to the peptidase S8 family
GPZ77_RS25740	COG1674	ftsk spoiiie
GPZ77_RS25750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPZ77_RS25755	COG1185	polyribonucleotide nucleotidyltransferase activity
GPZ77_RS25760	COG0612	Peptidase, M16
GPZ77_RS25765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPZ77_RS25785	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GPZ77_RS25790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPZ77_RS25795	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GPZ77_RS25820	COG2208	phosphoserine phosphatase activity
GPZ77_RS25820	COG2770	Histidine kinase
GPZ77_RS25830	COG2205	protein histidine kinase activity
GPZ77_RS25830	COG3850	Histidine kinase
GPZ77_RS25830	COG3437	response regulator, receiver
GPZ77_RS25830	COG4999	Histidine kinase
GPZ77_RS25840	COG1674	ftsk spoiiie
GPZ77_RS25850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPZ77_RS25860	COG1058	Belongs to the CinA family
GPZ77_RS25860	COG1546	Belongs to the CinA family
GPZ77_RS25865	COG1396	sequence-specific DNA binding
GPZ77_RS25880	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS25885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPZ77_RS25890	COG1201	RNA secondary structure unwinding
GPZ77_RS25895	COG2207	Transcriptional regulator
GPZ77_RS25895	COG1917	Cupin 2, conserved barrel domain protein
GPZ77_RS25920	COG0628	permease
GPZ77_RS25935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPZ77_RS25945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPZ77_RS25960	COG0765	amino acid transport
GPZ77_RS25965	COG0765	amino acid transport
GPZ77_RS25970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ77_RS25975	COG1126	abc transporter atp-binding protein
GPZ77_RS25980	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS26000	COG3395	kinase activity
GPZ77_RS26015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPZ77_RS26035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPZ77_RS26045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPZ77_RS26050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPZ77_RS26060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPZ77_RS26105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPZ77_RS26110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPZ77_RS26165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPZ77_RS26200	COG3842	ATPase activity
GPZ77_RS26205	COG1802	Transcriptional regulator
GPZ77_RS26210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPZ77_RS26225	COG0187	DNA topoisomerase II activity
GPZ77_RS26235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPZ77_RS26245	COG3290	protein histidine kinase activity
GPZ77_RS26255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPZ77_RS26260	COG0612	Peptidase, M16
GPZ77_RS26270	COG0739	heme binding
GPZ77_RS26275	COG1802	Transcriptional regulator
GPZ77_RS26280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPZ77_RS26300	COG1435	thymidine kinase activity
GPZ77_RS26355	COG0745	RESPONSE REGULATOR receiver
GPZ77_RS26360	COG2205	protein histidine kinase activity
GPZ77_RS26385	COG0756	dUTP diphosphatase activity
GPZ77_RS26395	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPZ77_RS26395	COG1136	(ABC) transporter
GPZ77_RS26425	COG0569	domain protein
GPZ77_RS26430	COG0531	amino acid
GPZ77_RS26435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPZ77_RS26500	COG3940	Belongs to the glycosyl hydrolase 43 family
GPZ77_RS26515	COG1278	Cold shock
GPZ77_RS26520	COG0513	Belongs to the DEAD box helicase family
GPZ77_RS26530	COG1278	Cold shock
GPZ77_RS26555	COG0252	asparaginase activity
GPZ77_RS26565	COG1799	cell septum assembly
GPZ77_RS26590	COG2040	homocysteine
GPZ77_RS26600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPZ77_RS26660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPZ77_RS26685	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS26725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPZ77_RS26740	COG1653	transport
GPZ77_RS26745	COG1175	transmembrane transport
GPZ77_RS26755	COG1940	carbohydrate kinase activity
GPZ77_RS26760	COG4213	ABC transporter substrate-binding protein
GPZ77_RS26770	COG4214	carbohydrate transport
GPZ77_RS26775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPZ77_RS26780	COG0531	amino acid
GPZ77_RS26790	COG1733	regulation of RNA biosynthetic process
GPZ77_RS26795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPZ77_RS26810	COG1316	TRANSCRIPTIONal
GPZ77_RS26815	COG1024	Enoyl-CoA hydratase
GPZ77_RS26815	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPZ77_RS26820	COG0183	Belongs to the thiolase family
GPZ77_RS26830	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPZ77_RS26845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPZ77_RS26855	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPZ77_RS26905	COG1116	anion transmembrane transporter activity
GPZ77_RS26920	COG4106	trans-aconitate 2-methyltransferase activity
GPZ77_RS26935	COG0789	Transcriptional regulator
GPZ77_RS26945	COG2326	polyphosphate kinase activity
GPZ77_RS26975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPZ77_RS26980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPZ77_RS27085	COG0346	lactoylglutathione lyase activity
GPZ77_RS27095	COG4195	phage-related replication protein
GPZ77_RS27115	COG1716	ATPase activity
GPZ77_RS27120	COG2409	Drug exporters of the RND superfamily
GPZ77_RS27210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GPZ77_RS27220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPZ77_RS27225	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GPZ77_RS27250	COG0175	sulfate reduction
GPZ77_RS27270	COG1609	Transcriptional regulator
GPZ77_RS27290	COG1621	beta-fructofuranosidase activity
GPZ77_RS27305	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS27330	COG1162	GTPase activity
GPZ77_RS27370	COG0028	Belongs to the TPP enzyme family
GPZ77_RS27390	COG1802	Transcriptional regulator
GPZ77_RS27415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS27420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS27425	COG1120	ATPase activity
GPZ77_RS27450	COG1132	(ABC) transporter
GPZ77_RS27455	COG1132	(ABC) transporter
GPZ77_RS27475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GPZ77_RS27480	COG2252	PERMEase
GPZ77_RS27490	COG4552	Acetyltransferase involved in intracellular survival and related
GPZ77_RS27505	COG1309	transcriptional regulator
GPZ77_RS27510	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS27530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GPZ77_RS27575	COG0513	Belongs to the DEAD box helicase family
GPZ77_RS27580	COG1278	Cold shock
GPZ77_RS27585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GPZ77_RS27610	COG1404	Belongs to the peptidase S8 family
GPZ77_RS27650	COG1595	DNA-templated transcription, initiation
GPZ77_RS27655	COG0598	Magnesium transport protein CorA
GPZ77_RS27665	COG2197	response regulator
GPZ77_RS27670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPZ77_RS27675	COG0318	PFAM AMP-dependent synthetase and ligase
GPZ77_RS27695	COG3960	tartronate-semialdehyde synthase activity
GPZ77_RS27720	COG3209	COG3209 Rhs family protein
GPZ77_RS27725	COG0753	catalase activity
GPZ77_RS27730	COG2084	Dehydrogenase
GPZ77_RS27735	COG3622	Belongs to the hyi family
GPZ77_RS27755	COG2351	hydroxyisourate hydrolase activity
GPZ77_RS27765	COG2233	PERMEase
GPZ77_RS27775	COG2233	PERMEase
GPZ77_RS27805	COG2755	lipolytic protein G-D-S-L family
GPZ77_RS27815	COG0746	molybdenum cofactor guanylyltransferase activity
GPZ77_RS27825	COG2197	response regulator
GPZ77_RS27830	COG4585	Histidine kinase
GPZ77_RS27845	COG1414	Transcriptional regulator
GPZ77_RS27850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GPZ77_RS27855	COG4266	Belongs to the allantoicase family
GPZ77_RS27860	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS27890	COG2197	response regulator
GPZ77_RS27905	COG0673	inositol 2-dehydrogenase activity
GPZ77_RS27940	COG1335	isochorismatase
GPZ77_RS27945	COG2259	Doxx family
GPZ77_RS27950	COG0783	Belongs to the Dps family
GPZ77_RS27975	COG1653	transport
GPZ77_RS27980	COG1175	transmembrane transport
GPZ77_RS27985	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS27990	COG2197	response regulator
GPZ77_RS27995	COG2267	carboxylic ester hydrolase activity
GPZ77_RS28000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS28005	COG0431	NADPH-dependent FMN reductase
GPZ77_RS28015	COG2508	Transcriptional regulator
GPZ77_RS28060	COG1280	lysine exporter protein (LysE YggA)
GPZ77_RS28085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPZ77_RS28095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPZ77_RS28100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPZ77_RS28115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPZ77_RS28120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GPZ77_RS28130	COG0584	glycerophosphoryl diester phosphodiesterase
GPZ77_RS28150	COG1376	ErfK ybiS ycfS ynhG family protein
GPZ77_RS28170	COG0405	Gamma-glutamyltransferase
GPZ77_RS28195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPZ77_RS28200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPZ77_RS28205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GPZ77_RS28210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS28215	COG1953	Uracil, thiamine, allantoin
GPZ77_RS28230	COG0483	inositol monophosphate 1-phosphatase activity
GPZ77_RS28270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPZ77_RS28275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPZ77_RS28295	COG1929	Belongs to the glycerate kinase type-1 family
GPZ77_RS28305	COG0410	ABC transporter
GPZ77_RS28315	COG0559	Belongs to the binding-protein-dependent transport system permease family
GPZ77_RS28320	COG0559	Belongs to the binding-protein-dependent transport system permease family
GPZ77_RS28345	COG0688	phosphatidylethanolamine metabolic process
GPZ77_RS28350	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS28380	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPZ77_RS28415	COG2362	D-Aminopeptidase
GPZ77_RS28420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPZ77_RS28425	COG0823	Involved in the tonB-independent uptake of proteins
GPZ77_RS28425	COG1506	peptidase
GPZ77_RS28425	COG4946	Tricorn protease homolog
GPZ77_RS28450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPZ77_RS28460	COG0477	Major facilitator Superfamily
GPZ77_RS28480	COG2226	methyltransferase
GPZ77_RS28485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPZ77_RS28540	COG0531	amino acid
GPZ77_RS28570	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPZ77_RS28575	COG2226	methyltransferase
GPZ77_RS28600	COG4977	sequence-specific DNA binding
GPZ77_RS28605	COG0604	alcohol dehydrogenase
GPZ77_RS28605	COG3321	synthase
GPZ77_RS28605	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS28610	COG0656	L-ascorbic acid biosynthetic process
GPZ77_RS28630	COG1335	isochorismatase
GPZ77_RS28640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPZ77_RS28650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPZ77_RS28695	COG2172	sigma factor antagonist activity
GPZ77_RS28720	COG1486	melibiose metabolic process
GPZ77_RS28735	COG3012	SEC-C Motif Domain Protein
GPZ77_RS28750	COG1793	dna ligase
GPZ77_RS28775	COG0488	(ABC) transporter
GPZ77_RS28795	COG1515	deoxyribonuclease V activity
GPZ77_RS28820	COG3268	Saccharopine dehydrogenase
GPZ77_RS28825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GPZ77_RS28835	COG0183	Belongs to the thiolase family
GPZ77_RS28840	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPZ77_RS28840	COG1024	Enoyl-CoA hydratase
GPZ77_RS28845	COG0789	Transcriptional regulator
GPZ77_RS28860	COG2814	Major facilitator Superfamily
GPZ77_RS28895	COG3568	Endonuclease Exonuclease Phosphatase
GPZ77_RS28900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPZ77_RS28915	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS28940	COG2936	dipeptidyl-peptidase activity
GPZ77_RS28950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPZ77_RS28965	COG0488	(ABC) transporter
GPZ77_RS28985	COG2183	response to ionizing radiation
GPZ77_RS28995	COG4977	sequence-specific DNA binding
GPZ77_RS29020	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GPZ77_RS29065	COG1388	LysM domain
GPZ77_RS29065	COG1134	teichoic acid transport
GPZ77_RS29075	COG1562	ergosterol biosynthetic process
GPZ77_RS29095	COG1657	PFAM Prenyltransferase squalene oxidase
GPZ77_RS29130	COG2755	lipolytic protein G-D-S-L family
GPZ77_RS29140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPZ77_RS29215	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS29220	COG3958	Transketolase
GPZ77_RS29225	COG3959	Transketolase, thiamine diphosphate binding domain
GPZ77_RS29250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPZ77_RS29280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPZ77_RS29335	COG1864	DNA RNA non-specific endonuclease
GPZ77_RS29335	COG3591	Belongs to the peptidase S1B family
GPZ77_RS29350	COG1404	Belongs to the peptidase S8 family
GPZ77_RS29395	COG3189	MarR family transcriptional regulator
GPZ77_RS29400	COG2124	cytochrome p450
GPZ77_RS29425	COG0545	Peptidyl-prolyl cis-trans isomerase
GPZ77_RS29475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPZ77_RS29480	COG1733	regulation of RNA biosynthetic process
GPZ77_RS29500	COG0297	glycogen (starch) synthase activity
GPZ77_RS29505	COG0489	protein tyrosine kinase activity
GPZ77_RS29520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPZ77_RS29540	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPZ77_RS29545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPZ77_RS29550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPZ77_RS29585	COG2226	methyltransferase
GPZ77_RS29590	COG2124	cytochrome p450
GPZ77_RS29595	COG2124	cytochrome p450
GPZ77_RS29615	COG1819	glycosyl
GPZ77_RS29635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPZ77_RS29655	COG0542	response to heat
GPZ77_RS29680	COG2318	DinB family
GPZ77_RS29785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GPZ77_RS29850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPZ77_RS29855	COG3279	Response regulator of the LytR AlgR family
GPZ77_RS29865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPZ77_RS29870	COG3275	phosphorelay sensor kinase activity
GPZ77_RS29900	COG0726	polysaccharide deacetylase
GPZ77_RS29945	COG0583	DNA-binding transcription factor activity
GPZ77_RS29955	COG1053	succinate dehydrogenase
GPZ77_RS29960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPZ77_RS29970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS30000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GPZ77_RS30005	COG0121	glutamine amidotransferase
GPZ77_RS30010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPZ77_RS30015	COG3572	ergothioneine biosynthetic process
GPZ77_RS30030	COG2268	Band 7 protein
GPZ77_RS30050	COG1609	Transcriptional regulator
GPZ77_RS30060	COG0183	Belongs to the thiolase family
GPZ77_RS30065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPZ77_RS30070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPZ77_RS30140	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GPZ77_RS30145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPZ77_RS30150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPZ77_RS30165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS30170	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPZ77_RS30175	COG1120	ATPase activity
GPZ77_RS30190	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPZ77_RS30200	COG1169	isochorismate synthase
GPZ77_RS30215	COG3940	Belongs to the glycosyl hydrolase 43 family
GPZ77_RS30240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPZ77_RS30240	COG1796	DNA polymerase
GPZ77_RS30250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPZ77_RS30255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPZ77_RS30265	COG1505	serine-type exopeptidase activity
GPZ77_RS30325	COG1414	Transcriptional regulator
GPZ77_RS30330	COG3467	pyridoxamine 5'-phosphate
GPZ77_RS30340	COG1414	Transcriptional regulator
GPZ77_RS30350	COG4608	Belongs to the ABC transporter superfamily
GPZ77_RS30365	COG0747	negative chemotaxis
GPZ77_RS30370	COG1126	abc transporter atp-binding protein
GPZ77_RS30375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPZ77_RS30380	COG0765	amino acid transport
GPZ77_RS30385	COG0765	amino acid transport
GPZ77_RS30390	COG2409	Drug exporters of the RND superfamily
GPZ77_RS30395	COG1846	Transcriptional regulator
GPZ77_RS30400	COG0702	epimerase
GPZ77_RS30430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPZ77_RS30445	COG1573	uracil-dna glycosylase
GPZ77_RS30450	COG2124	cytochrome p450
GPZ77_RS30495	COG0492	ferredoxin-NADP+ reductase activity
GPZ77_RS30510	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS30515	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS30530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPZ77_RS30535	COG0444	Belongs to the ABC transporter superfamily
GPZ77_RS30560	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPZ77_RS30645	COG2234	aminopeptidase activity
GPZ77_RS30670	COG0009	L-threonylcarbamoyladenylate synthase
GPZ77_RS30705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPZ77_RS30730	COG2226	methyltransferase
GPZ77_RS30750	COG2318	DinB family
GPZ77_RS30765	COG0142	geranyltranstransferase activity
GPZ77_RS30780	COG2267	carboxylic ester hydrolase activity
GPZ77_RS30800	COG2124	cytochrome p450
GPZ77_RS30805	COG2124	cytochrome p450
GPZ77_RS30825	COG1959	2 iron, 2 sulfur cluster binding
GPZ77_RS30885	COG2340	Cysteine-rich secretory protein family
GPZ77_RS30905	COG2356	endonuclease I
GPZ77_RS30915	COG3866	Pectate lyase
GPZ77_RS30925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPZ77_RS30935	COG2508	Transcriptional regulator
GPZ77_RS30945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GPZ77_RS30955	COG1595	DNA-templated transcription, initiation
GPZ77_RS30995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPZ77_RS31070	COG1012	belongs to the aldehyde dehydrogenase family
GPZ77_RS31080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPZ77_RS31095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPZ77_RS31100	COG3239	Fatty acid desaturase
GPZ77_RS31160	COG2018	Roadblock/LC7 domain
GPZ77_RS31170	COG1793	dna ligase
GPZ77_RS31185	COG0726	polysaccharide deacetylase
GPZ77_RS31265	COG1960	acyl-CoA dehydrogenase activity
GPZ77_RS31295	COG0477	Major facilitator Superfamily
GPZ77_RS31320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPZ77_RS31325	COG1278	Cold shock
GPZ77_RS31340	COG0542	response to heat
GPZ77_RS31370	COG2197	response regulator
GPZ77_RS31375	COG1051	belongs to the nudix hydrolase family
GPZ77_RS31395	COG0254	rRNA binding
GPZ77_RS31415	COG2318	DinB family
GPZ77_RS31455	COG1609	Transcriptional regulator
GPZ77_RS31460	COG5297	Belongs to the glycosyl hydrolase family 6
GPZ77_RS31470	COG5297	Belongs to the glycosyl hydrolase family 6
GPZ77_RS31470	COG4733	cellulase activity
GPZ77_RS31485	COG1175	transmembrane transport
GPZ77_RS31490	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS31525	COG1414	Transcriptional regulator
GPZ77_RS31530	COG3386	PFAM SMP-30 Gluconolaconase
GPZ77_RS31540	COG1595	DNA-templated transcription, initiation
GPZ77_RS31550	COG4677	pectinesterase activity
GPZ77_RS31555	COG3866	Pectate lyase
GPZ77_RS31560	COG2755	lipolytic protein G-D-S-L family
GPZ77_RS31600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPZ77_RS31605	COG1802	Transcriptional regulator
GPZ77_RS31615	COG1070	Carbohydrate kinase
GPZ77_RS31635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPZ77_RS31650	COG0598	Magnesium transport protein CorA
GPZ77_RS31715	COG0395	ABC-type sugar transport system, permease component
GPZ77_RS31765	COG1695	Transcriptional regulator
GPZ77_RS31780	COG3866	Pectate lyase
GPZ77_RS31835	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPZ77_RS31865	COG4989	oxidoreductase activity
GPZ77_RS31895	COG1191	sigma factor activity
GPZ77_RS31920	COG1295	ribonuclease BN
GPZ77_RS31920	COG1959	2 iron, 2 sulfur cluster binding
GPZ77_RS31945	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GPZ77_RS31950	COG1472	Belongs to the glycosyl hydrolase 3 family
GPZ77_RS31965	COG0328	RNA-DNA hybrid ribonuclease activity
GPZ77_RS32030	COG2814	Major facilitator Superfamily
GPZ77_RS32100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GPZ77_RS32105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GPZ77_RS32110	COG2080	2 iron, 2 sulfur cluster binding
GPZ77_RS32150	COG1295	ribonuclease BN
GPZ77_RS32210	COG0137	argininosuccinate synthase activity
GPZ77_RS32285	COG0798	PFAM Bile acid sodium symporter
GPZ77_RS32290	COG0640	Transcriptional regulator
GPZ77_RS32305	COG2326	polyphosphate kinase activity
GPZ77_RS32330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS32380	COG2318	DinB family
GPZ77_RS32385	COG0789	Transcriptional regulator
GPZ77_RS32395	COG1595	DNA-templated transcription, initiation
GPZ77_RS32415	COG0326	Molecular chaperone. Has ATPase activity
GPZ77_RS32480	COG0596	Alpha beta hydrolase
GPZ77_RS32485	COG2770	Histidine kinase
GPZ77_RS32485	COG2208	phosphoserine phosphatase activity
GPZ77_RS32510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GPZ77_RS32530	COG2188	Transcriptional regulator
GPZ77_RS32535	COG2188	Transcriptional regulator
GPZ77_RS32570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GPZ77_RS32605	COG0583	DNA-binding transcription factor activity
GPZ77_RS32650	COG0789	Transcriptional regulator
GPZ77_RS32660	COG0596	Alpha beta hydrolase
GPZ77_RS32685	COG1501	Belongs to the glycosyl hydrolase 31 family
GPZ77_RS32710	COG4209	transmembrane transport
GPZ77_RS32735	COG1609	Transcriptional regulator
GPZ77_RS32745	COG3507	Belongs to the glycosyl hydrolase 43 family
GPZ77_RS32770	COG2205	protein histidine kinase activity
GPZ77_RS32785	COG2186	Transcriptional regulator
GPZ77_RS32795	COG4948	Mandelate Racemase Muconate Lactonizing
GPZ77_RS32800	COG1028	Short-chain dehydrogenase reductase Sdr
GPZ77_RS32820	COG3458	cephalosporin-C deacetylase activity
GPZ77_RS32835	COG3693	PFAM glycoside hydrolase, family 10
GPZ77_RS32855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPZ77_RS32925	COG0515	serine threonine protein kinase
GPZ77_RS32940	COG1132	(ABC) transporter
GPZ77_RS32945	COG2197	response regulator
GPZ77_RS33015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPZ77_RS33020	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPZ77_RS33025	COG1316	TRANSCRIPTIONal
GPZ77_RS33035	COG0489	protein tyrosine kinase activity
GPZ77_RS33040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPZ77_RS33045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPZ77_RS33065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPZ77_RS33080	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS33085	COG0438	transferase activity, transferring glycosyl groups
GPZ77_RS33410	COG1131	(ABC) transporter
GPZ77_RS33550	COG1175	transmembrane transport
GPZ77_RS33555	COG3833	ABC-type maltose transport systems, permease component
GPZ77_RS33560	COG2723	6-phospho-beta-galactosidase activity
GPZ77_RS33610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPZ77_RS33615	COG0431	NADPH-dependent FMN reductase
GPZ77_RS33620	COG0477	Major facilitator Superfamily
GPZ77_RS33850	COG1366	Belongs to the anti-sigma-factor antagonist family
GPZ77_RS33900	COG3226	Transcriptional regulator
GPZ77_RS33905	COG0596	Alpha beta hydrolase
GPZ77_RS33910	COG2770	Histidine kinase
GPZ77_RS33910	COG2208	phosphoserine phosphatase activity
GPZ77_RS34125	COG4325	translation initiation factor activity
GPZ77_RS34175	COG0477	Major facilitator Superfamily
GPZ77_RS34260	COG0629	single-stranded DNA binding
GPZ77_RS34345	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GPZ77_RS34650	COG5280	Phage tail tape measure protein TP901
GPZ77_RS34650	COG3953	SLT domain