locus-tag class description HA039_RS00075 ENOG4105CPC Aldo Keto reductase HA039_RS00095 ENOG4105C54 Major Facilitator superfamily HA039_RS00100 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HA039_RS00125 ENOG4105DRS transport system, permease HA039_RS00135 ENOG4107YY3 extracellular solute-binding protein family 1 HA039_RS00140 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS00150 ENOG4107R6F Alpha Beta Hydrolase Fold protein HA039_RS00165 ENOG4105K56 Transcriptional regulator HA039_RS00170 ENOG4108ZHJ Organic hydroperoxide resistance protein HA039_RS00175 ENOG410905P Pyridoxamine 5-phosphate HA039_RS00190 ENOG41080HI glycine oxidase HA039_RS00195 ENOG4107JC6 Membrane HA039_RS00200 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HA039_RS00210 ENOG4106JDR secreted HA039_RS00250 ENOG4105CV8 reductase HA039_RS00270 ENOG4105TVJ transport system, permease HA039_RS00275 ENOG4105DQ5 transport system permease protein HA039_RS00305 ENOG4105EZR dyp-type peroxidase family protein HA039_RS00350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HA039_RS00355 ENOG4105CR4 methylisocitrate lyase HA039_RS00395 ENOG4105CD8 aminopeptidase N HA039_RS00400 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HA039_RS00420 ENOG4108JGH Tetr family transcriptional regulator HA039_RS00425 ENOG4105DGI Alkaline phosphatase HA039_RS00430 ENOG4105VBF alkaline shock protein HA039_RS00500 ENOG4107RCH Diaminopropionate ammonia-lyase HA039_RS00530 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HA039_RS00560 ENOG4105EX0 alpha-galactosidase HA039_RS00580 ENOG4105E2R ROK family HA039_RS00595 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HA039_RS00605 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HA039_RS00625 ENOG4108638 50S ribosomal protein L36 HA039_RS00640 ENOG4105C1J atp-dependent rna helicase HA039_RS00645 ENOG4105VEQ Cold shock protein HA039_RS00665 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HA039_RS00705 ENOG4105K4I Scp-like extracellular HA039_RS00720 ENOG4105CC5 ABC transporter HA039_RS00725 ENOG4105FDK ABC transporter HA039_RS00730 ENOG4105DSE periplasmic solute binding protein HA039_RS00735 ENOG4105CHR reductase HA039_RS00745 ENOG4107JC6 Membrane HA039_RS00775 ENOG4105CV8 reductase HA039_RS00795 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HA039_RS00810 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS00855 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HA039_RS00860 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HA039_RS00885 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HA039_RS00895 ENOG4105M4P Tetr family transcriptional regulator HA039_RS00900 ENOG4105DY8 decarboxylase HA039_RS00915 ENOG4105WQT MbtH domain protein HA039_RS00950 ENOG4108JQ7 (ABC) transporter HA039_RS00955 ENOG4105C3U ABC transporter HA039_RS00960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS00970 ENOG4105DEF Extracellular solute-binding protein, family 5 HA039_RS00980 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HA039_RS00990 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HA039_RS01005 ENOG4105D8K carboxyl transferase HA039_RS01010 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS01015 ENOG4105F1N DNA alkylation repair HA039_RS01020 ENOG4105CV8 reductase HA039_RS01025 ENOG4105F27 Major Facilitator HA039_RS01030 ENOG4105NRA 50s ribosomal protein l31 type b HA039_RS01040 ENOG4108ZM9 phosphoglycerate mutase HA039_RS01065 ENOG4105VEQ Cold shock protein HA039_RS01070 ENOG4105CPC Aldo Keto reductase HA039_RS01085 ENOG41068HZ 50S ribosomal protein L32 HA039_RS01090 ENOG4105CKI cobalamin synthesis protein HA039_RS01095 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HA039_RS01100 ENOG4105CC5 ABC transporter HA039_RS01105 ENOG4105DIK (ABC) transporter HA039_RS01115 ENOG4105DSE periplasmic solute binding protein HA039_RS01150 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HA039_RS01155 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS01160 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HA039_RS01165 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HA039_RS01185 ENOG410900P UPF0336 protein HA039_RS01195 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HA039_RS01205 ENOG4105CHR reductase HA039_RS01210 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HA039_RS01225 ENOG4105F95 Monooxygenase HA039_RS01265 ENOG4105ECR NmrA family HA039_RS01305 ENOG4106A3M Cytochrome p-450 HA039_RS01310 ENOG41065KQ synthase HA039_RS01315 ENOG41064MX Tetr family transcriptional regulator HA039_RS01320 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HA039_RS01335 ENOG4108W5M transcriptional regulator HA039_RS01345 ENOG4108ZBR Gcn5-related n-acetyltransferase HA039_RS01350 ENOG4105CPC Aldo Keto reductase HA039_RS01355 ENOG4105W1Y Transcriptional regulator HA039_RS01365 ENOG4105JZI cytochrome P450 HA039_RS01375 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HA039_RS01390 ENOG4105BZ1 (ABC) transporter HA039_RS01400 ENOG4105E1F short-chain dehydrogenase reductase HA039_RS01405 ENOG4105F7P transcriptional regulator AsnC family HA039_RS01430 ENOG4107U9T Pfam:Ribonuclease_BN HA039_RS01445 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HA039_RS01450 ENOG4105CYP glycoside hydrolase, family HA039_RS01460 ENOG4105GWZ Roadblock lc7 family protein HA039_RS01500 ENOG4105C0D helicase HA039_RS01510 ENOG4107SCA Formamidase (EC 3.5.1.49) HA039_RS01530 ENOG4105D2B acyl-CoA dehydrogenase HA039_RS01535 ENOG4105D2B acyl-CoA dehydrogenase HA039_RS01540 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HA039_RS01565 ENOG4105I82 acetyl xylan esterase HA039_RS01590 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HA039_RS01600 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HA039_RS01625 ENOG4105DEN Luciferase family HA039_RS01630 ENOG4105DEN Luciferase family HA039_RS01650 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HA039_RS01660 ENOG4106T9R serine protease HA039_RS01665 ENOG4108762 serine threonine protein kinase HA039_RS01685 ENOG4105DU6 RNA polymerase HA039_RS01690 ENOG4108X07 Tetr family transcriptional regulator HA039_RS01715 ENOG4106UDK Cellulose-binding, family II HA039_RS01735 ENOG4105ECY inositol monophosphatase HA039_RS01745 ENOG4105DQE DNA ligase HA039_RS01765 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HA039_RS01810 ENOG4106KE4 Dehydrogenase HA039_RS01850 ENOG41060NJ transcriptional regulator HA039_RS01855 ENOG4105DET Rhamnulokinase HA039_RS01890 ENOG4105CHJ isochorismatase hydrolase HA039_RS01925 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HA039_RS01930 ENOG41080V3 Major Facilitator superfamily HA039_RS01950 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HA039_RS01965 ENOG410880H cysteine synthase HA039_RS02000 ENOG4105CMD Transcriptional regulator, GntR family HA039_RS02030 ENOG4105BZU Histidine kinase HA039_RS02035 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS02050 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HA039_RS02105 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HA039_RS02110 ENOG4105CK2 sodium dicarboxylate symporter HA039_RS02130 ENOG4105EQ0 Major Facilitator superfamily HA039_RS02140 ENOG4105ENX hydrolase HA039_RS02145 ENOG4106NZI LysR family Transcriptional regulator HA039_RS02200 ENOG4105CHR reductase HA039_RS02205 ENOG4108KC1 acyl-Coa dehydrogenase HA039_RS02225 ENOG4105CPC Aldo Keto reductase HA039_RS02230 ENOG4105CY0 Metallo-Beta-Lactamase HA039_RS02235 ENOG4105CS1 NAD(P)H quinone oxidoreductase HA039_RS02240 ENOG4105KVH Transcriptional regulator HA039_RS02250 ENOG4106NZI LysR family Transcriptional regulator HA039_RS02265 ENOG4105CY0 Metallo-Beta-Lactamase HA039_RS02270 ENOG4105DEN Luciferase family HA039_RS02330 ENOG4105EUB pirin domain protein HA039_RS02340 ENOG4105DQE DNA ligase HA039_RS02345 ENOG4107QRI Phosphoketolase HA039_RS02380 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HA039_RS02395 ENOG4105C57 major facilitator superfamily HA039_RS02400 ENOG4105E5Q amino acid AbC transporter HA039_RS02420 ENOG4105E5Q amino acid AbC transporter HA039_RS02425 ENOG4105CDA abc transporter atp-binding protein HA039_RS02430 ENOG4105EAB amino acid AbC transporter HA039_RS02445 ENOG4105DWV Homoserine O-trans-acetylase HA039_RS02450 ENOG4105C0X amino acid HA039_RS02490 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HA039_RS02505 ENOG4105D9G High-affinity HA039_RS02550 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS02555 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS02595 ENOG4105DBV ornithine carbamoyltransferase HA039_RS02620 ENOG4105C5S asparaginyl-tRNA synthetase HA039_RS02625 ENOG4105CBC glutamate synthase HA039_RS02635 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS02655 ENOG410880H cysteine synthase HA039_RS02680 ENOG4108ZP8 Acetolactate synthase small subunit HA039_RS02685 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HA039_RS02700 ENOG4105DU1 integral membrane protein, terc HA039_RS02715 ENOG4108IG5 Transcriptional regulator HA039_RS02735 ENOG4108QMY dioxygenase HA039_RS02745 ENOG4105E2A Dehydrogenase HA039_RS02765 ENOG41082JN Transcriptional regulator HA039_RS02790 ENOG4107QN2 dihydrolipoyl dehydrogenase HA039_RS02795 ENOG41080RH Thioredoxin HA039_RS02805 ENOG41060NJ transcriptional regulator HA039_RS02825 ENOG4105C9B Cysteine desulfurase HA039_RS02850 ENOG4105D1K glutamate--cysteine ligase HA039_RS02855 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HA039_RS02860 ENOG4108V75 Glutamine amidotransferase HA039_RS02865 ENOG41067HS methyltransferase HA039_RS02885 ENOG4105BZU Histidine kinase HA039_RS02890 ENOG4105D2N Aldolase HA039_RS02895 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HA039_RS02905 ENOG4105CMT Dihydroxyacetone kinase HA039_RS02910 ENOG4105WKW Pfam:DUF1458 HA039_RS02920 ENOG4105DEN Luciferase family HA039_RS02935 ENOG4105E33 succinate dehydrogenase HA039_RS02950 ENOG4105C5Q Transcriptional regulator HA039_RS02955 ENOG4105BZU Histidine kinase HA039_RS02990 ENOG4108ZJ4 polysaccharide deacetylase HA039_RS03015 ENOG4108HRK Histidine kinase HA039_RS03030 ENOG4108NEV two component transcriptional regulator, LytTR family HA039_RS03090 ENOG4105HSS phospholipase C HA039_RS03095 ENOG4105DBE peroxidase HA039_RS03125 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HA039_RS03130 ENOG4107QPH glycogen) synthase HA039_RS03150 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS03170 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HA039_RS03180 ENOG4105D7K pfkb domain protein HA039_RS03185 ENOG4105CPQ Dehydrogenase HA039_RS03205 ENOG4105E98 transcriptional regulator DeoR family HA039_RS03210 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HA039_RS03280 ENOG4105DGI Alkaline phosphatase HA039_RS03290 ENOG4105DUM transcriptional regulator, lysR family HA039_RS03295 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS03300 ENOG4105CFN oxalyl-CoA decarboxylase HA039_RS03305 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HA039_RS03325 ENOG4105RD7 BadF BadG BcrA BcrD HA039_RS03335 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HA039_RS03355 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HA039_RS03375 ENOG4107QSI ABC, transporter HA039_RS03380 ENOG4108JQ7 (ABC) transporter HA039_RS03400 ENOG4105FDP GntR family transcriptional regulator HA039_RS03410 ENOG4105C02 permease HA039_RS03435 ENOG4106A3M Cytochrome p-450 HA039_RS03450 ENOG4105GRZ Ycii-related protein HA039_RS03455 ENOG4105CHP RNA polymerase HA039_RS03470 ENOG4105N14 lysine exporter protein LysE YggA HA039_RS03510 ENOG4107U9T Pfam:Ribonuclease_BN HA039_RS03530 ENOG4105X1P Steroid delta-isomerase HA039_RS03540 ENOG4105ECQ AraC Family Transcriptional Regulator HA039_RS03555 ENOG410832A alpha/beta hydrolase fold HA039_RS03560 ENOG4108KC1 acyl-Coa dehydrogenase HA039_RS03565 ENOG4108FN7 Aldo keto reductase HA039_RS03600 ENOG4108ZXC Two component transcriptional regulator, luxr family HA039_RS03610 ENOG4105DU0 nucleoside hydrolase HA039_RS03615 ENOG4108URH decarboxylase HA039_RS03635 ENOG4108KXM LysR family Transcriptional regulator HA039_RS03660 ENOG41086D8 Transcriptional regulator HA039_RS03685 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HA039_RS03700 ENOG41080R8 Conserved Protein HA039_RS03710 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HA039_RS03765 ENOG4105BZU Histidine kinase HA039_RS03795 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HA039_RS03800 ENOG4108428 Inherit from COG: -acetyltransferase HA039_RS03815 ENOG4105JSC dimethylmenaquinone methyltransferase HA039_RS03860 ENOG4105C1J atp-dependent rna helicase HA039_RS03885 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HA039_RS03910 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HA039_RS03950 ENOG4105CHR reductase HA039_RS03970 ENOG4105PDP Short chain dehydrogenase HA039_RS03995 ENOG4105EYF MMPL domain protein HA039_RS04000 ENOG4105BZU Histidine kinase HA039_RS04005 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS04010 ENOG4107RN3 metallophosphoesterase HA039_RS04015 ENOG4105EMN RNA polymerase sigma factor HA039_RS04030 ENOG4105CF7 AraC family transcriptional regulator HA039_RS04105 ENOG4108FN7 Aldo keto reductase HA039_RS04115 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HA039_RS04125 ENOG4108JCI Transcriptional regulator HA039_RS04130 ENOG4108IY8 ABC, transporter HA039_RS04140 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HA039_RS04145 ENOG41060NJ transcriptional regulator HA039_RS04155 ENOG4105VZ8 Transcriptional regulator HA039_RS04190 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HA039_RS04195 ENOG4105E98 transcriptional regulator DeoR family HA039_RS04205 ENOG4108U3T pfkb domain protein HA039_RS04235 ENOG4105D4P Coproporphyrinogen iii oxidase HA039_RS04245 ENOG41090WU lipolytic protein G-D-S-L family HA039_RS04255 ENOG4105M2Z protein tyrosine serine phosphatase HA039_RS04290 ENOG4105EWU Squalene--hopene cyclase HA039_RS04300 ENOG4107S11 squalene-associated FAD-dependent desaturase HA039_RS04310 ENOG4105FBD synthase HA039_RS04315 ENOG4105EY8 ABC transporter HA039_RS04335 ENOG4108MDK Dehydrogenase HA039_RS04360 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HA039_RS04370 ENOG41060WC Enoyl-CoA hydratase HA039_RS04380 ENOG4105ECQ AraC Family Transcriptional Regulator HA039_RS04390 ENOG4105BZM domain protein HA039_RS04395 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HA039_RS04400 ENOG4108Z6Z Transcriptional regulator HA039_RS04410 ENOG4105C5H ABC transporter HA039_RS04435 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS04450 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HA039_RS04455 ENOG4105CHU acetyl-coa acetyltransferase HA039_RS04460 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HA039_RS04470 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HA039_RS04490 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HA039_RS04515 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HA039_RS04550 ENOG4105DQE DNA ligase HA039_RS04580 ENOG4105K5B UPF0225 protein HA039_RS04600 ENOG4105DRR Transcriptional regulator, GntR family HA039_RS04605 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HA039_RS04620 ENOG4105J4Q Transcriptional regulator HA039_RS04625 ENOG4105CXK mandelate racemase muconate lactonizing HA039_RS04650 ENOG4108HWW ABC transporter HA039_RS04655 ENOG4105F8D glycoside hydrolase family 4 HA039_RS04695 ENOG4108UHU Aldolase HA039_RS04705 ENOG4105CXK mandelate racemase muconate lactonizing HA039_RS04710 ENOG4105JXH GntR family transcriptional regulator HA039_RS04730 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HA039_RS04740 ENOG4105EX0 alpha-galactosidase HA039_RS04745 ENOG4105DKQ ROK family HA039_RS04770 ENOG41066UM arsR family transcriptional regulator HA039_RS04775 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS04780 ENOG4105JQN Transcriptional regulator HA039_RS04785 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HA039_RS04790 ENOG4105CPQ Dehydrogenase HA039_RS04845 ENOG4105DZ1 carboxypeptidase HA039_RS04850 ENOG4105DDN Pentapeptide repeat-containing protein HA039_RS04895 ENOG4105C26 Dehydrogenase HA039_RS04905 ENOG4105CMV Succinyl-CoA synthetase subunit beta HA039_RS04925 ENOG4105FCD Major Facilitator HA039_RS04960 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HA039_RS04990 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HA039_RS04995 ENOG4105CNN ABC, transporter HA039_RS05000 ENOG4105C2J ABC transporter HA039_RS05005 ENOG4105DKQ ROK family HA039_RS05010 ENOG4107SET aldo keto reductase HA039_RS05015 ENOG4105NAE bifunctional deaminase-reductase domain protein HA039_RS05035 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HA039_RS05050 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HA039_RS05055 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HA039_RS05065 ENOG4107QHI -hydrogenase HA039_RS05070 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HA039_RS05080 ENOG4105DHU Bile acid HA039_RS05085 ENOG4106NZI LysR family Transcriptional regulator HA039_RS05095 ENOG4105CV8 reductase HA039_RS05110 ENOG4106GCT Dehydratase HA039_RS05125 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HA039_RS05150 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS05185 ENOG4105BZ7 extracellular solute-binding protein family 1 HA039_RS05210 ENOG4105CFC Transporter HA039_RS05265 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HA039_RS05275 ENOG4107HQ7 repeat protein HA039_RS05300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HA039_RS05305 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HA039_RS05310 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HA039_RS05315 ENOG4108ME1 Peptidase M55 D-aminopeptidase HA039_RS05320 ENOG41064MX Tetr family transcriptional regulator HA039_RS05330 ENOG4107URF beta-phospho-glucomutase HA039_RS05340 ENOG4108UTZ Dihydroxyacetone kinase HA039_RS05345 ENOG4105CMT Dihydroxyacetone kinase HA039_RS05385 ENOG4105BZU Histidine kinase HA039_RS05390 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS05425 ENOG4105CI0 Citrate lyase HA039_RS05435 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS05440 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HA039_RS05465 ENOG4105C32 Amino acid ABC transporter (Permease) HA039_RS05470 ENOG4105C32 Amino acid ABC transporter (Permease) HA039_RS05475 ENOG4105C0Z ABC transporter HA039_RS05480 ENOG4108IV0 ABC, transporter HA039_RS05500 ENOG4105BZW Glycerate kinase HA039_RS05510 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HA039_RS05515 ENOG4108MTT Glutamate-rich protein grpB HA039_RS05520 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HA039_RS05530 ENOG4108UVJ appr-1-p processing domain protein HA039_RS05545 ENOG4105ECY inositol monophosphatase HA039_RS05560 ENOG4108YYH Nadph-dependent fmn reductase HA039_RS05570 ENOG4108JNI Alpha beta hydrolase HA039_RS05580 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HA039_RS05590 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HA039_RS05595 ENOG4105C8Y Acetylornithine aminotransferase HA039_RS05615 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HA039_RS05620 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HA039_RS05650 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HA039_RS05725 ENOG4105CSU acyl-Coa dehydrogenase HA039_RS05745 ENOG4108JA1 polyketide synthase HA039_RS05755 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HA039_RS05760 ENOG4106JDR secreted HA039_RS05790 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HA039_RS05810 ENOG4105DRP amino acid AbC transporter HA039_RS05815 ENOG4105EAD ABC transporter HA039_RS05820 ENOG4107UBR Extracellular solute-binding protein family 3 HA039_RS05835 ENOG4105E8R UPF0173 metal-dependent hydrolase HA039_RS05840 ENOG4105F2Z 3-oxoadipate enol-lactonase HA039_RS05860 ENOG4105E1F short-chain dehydrogenase reductase HA039_RS05875 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS05885 ENOG4105E1F short-chain dehydrogenase reductase HA039_RS05910 ENOG4107TXC Transcriptional regulator HA039_RS05915 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HA039_RS05920 ENOG4105C57 major facilitator superfamily HA039_RS05950 ENOG4105E8G Major facilitator Superfamily HA039_RS05960 ENOG41068WN HA039_RS06000 ENOG4105C57 major facilitator superfamily HA039_RS06005 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HA039_RS06025 ENOG4108WUH Transcriptional regulator, TetR family HA039_RS06035 ENOG4105C5I Dehydrogenase HA039_RS06055 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HA039_RS06065 ENOG4105E2R ROK family HA039_RS06120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HA039_RS06140 ENOG4105C57 major facilitator superfamily HA039_RS06150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HA039_RS06165 ENOG4105C57 major facilitator superfamily HA039_RS06175 ENOG4105DKQ ROK family HA039_RS06180 ENOG4105C2J ABC transporter HA039_RS06185 ENOG4105CNN ABC, transporter HA039_RS06200 ENOG4105CK5 oxidoreductase HA039_RS06210 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS06220 ENOG4105DHG Allantoate amidinohydrolase HA039_RS06230 ENOG4107HP6 Transcriptional regulator HA039_RS06245 ENOG4107R9S Malate synthase HA039_RS06255 ENOG4105KVH Transcriptional regulator HA039_RS06275 ENOG4105CWX Alpha-1,2-mannosidase HA039_RS06280 ENOG4108KPJ rna polymerase sigma factor HA039_RS06285 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HA039_RS06325 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HA039_RS06330 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HA039_RS06335 ENOG41060W2 glyoxylate carboligase HA039_RS06345 ENOG4107S9F NmrA family HA039_RS06355 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS06360 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HA039_RS06390 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HA039_RS06400 ENOG4105XRQ Xanthine dehydrogenase accessory factor HA039_RS06405 ENOG4105C7N Xanthine uracil vitamin C permease HA039_RS06410 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HA039_RS06435 ENOG4105BZ1 (ABC) transporter HA039_RS06440 ENOG4105BZ1 (ABC) transporter HA039_RS06470 ENOG4106A3M Cytochrome p-450 HA039_RS06480 ENOG4105DRR Transcriptional regulator, GntR family HA039_RS06500 ENOG4105C7K acetolactate synthase HA039_RS06525 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HA039_RS06540 ENOG4105CG3 alpha amylase, catalytic region HA039_RS06555 ENOG4105CS1 NAD(P)H quinone oxidoreductase HA039_RS06565 ENOG4105BZU Histidine kinase HA039_RS06570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HA039_RS06590 ENOG4105CSU acyl-Coa dehydrogenase HA039_RS06595 ENOG4107RR1 TRANSCRIPTIONal HA039_RS06615 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HA039_RS06620 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) HA039_RS06640 ENOG4108IY8 ABC, transporter HA039_RS06645 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HA039_RS06655 ENOG4105MC2 DSBA oxidoreductase HA039_RS06660 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HA039_RS06690 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HA039_RS06740 ENOG4106A3M Cytochrome p-450 HA039_RS06745 ENOG4105Q36 FHA domain containing protein HA039_RS06765 ENOG4105K6T rare lipoprotein A HA039_RS06780 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HA039_RS06795 ENOG4105E0X reductase HA039_RS06800 ENOG4105DFU Cell wall formation (By similarity) HA039_RS06855 ENOG4105E18 UPF0276 protein HA039_RS06940 ENOG4105EC2 ftsk spoIIIe HA039_RS06950 ENOG4106F1P AAA ATPase, central domain protein HA039_RS06960 ENOG4107JTW chlorite dismutase HA039_RS06965 ENOG4105C1Q protoporphyrinogen oxidase HA039_RS06975 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HA039_RS06980 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HA039_RS07000 ENOG4105CHU acetyl-coa acetyltransferase HA039_RS07005 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HA039_RS07025 ENOG4105CUB amino acid HA039_RS07030 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HA039_RS07035 ENOG4108HWW ABC transporter HA039_RS07040 ENOG4105C2J ABC transporter HA039_RS07045 ENOG4105DFW ABC transporter HA039_RS07050 ENOG4105E2R ROK family HA039_RS07060 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HA039_RS07080 ENOG4107QM5 aconitate hydratase HA039_RS07105 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HA039_RS07115 ENOG4105CMG Carbohydrate kinase HA039_RS07120 ENOG4105E98 transcriptional regulator DeoR family HA039_RS07170 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HA039_RS07195 ENOG4108I5C dEAD DEAH box helicase HA039_RS07205 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HA039_RS07240 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS07265 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HA039_RS07305 ENOG4105D0M Protease HtpX homolog HA039_RS07325 ENOG4105DBV ornithine carbamoyltransferase HA039_RS07330 ENOG4105CEU Arginine dihydrolase HA039_RS07335 ENOG4107S1Q Phosphatase HA039_RS07345 ENOG4107QK5 Homocysteine s-methyltransferase HA039_RS07395 ENOG4105DRS transport system, permease HA039_RS07405 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HA039_RS07415 ENOG4105CJN penicillin-binding protein HA039_RS07480 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HA039_RS07490 ENOG41067SE Tetr family transcriptional regulator HA039_RS07540 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HA039_RS07575 ENOG4105C8U phosphate abc transporter HA039_RS07585 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HA039_RS07595 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HA039_RS07605 ENOG4108VQT Alpha beta hydrolase fold protein HA039_RS07625 ENOG4108IXY short-chain dehydrogenase reductase HA039_RS07655 ENOG4107RSM transcriptional regulator HA039_RS07660 ENOG4105CHR reductase HA039_RS07670 ENOG4105ERR inositol mono-phosphatase HA039_RS07675 ENOG4105EQK -acetyltransferase HA039_RS07695 ENOG4108K6T Protein of unknown function (DUF1205) HA039_RS07725 ENOG4107R7Y intracellular protease Pfpi family HA039_RS07735 ENOG4107QM2 Aldo Keto reductase HA039_RS07750 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HA039_RS07765 ENOG41084I7 Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures HA039_RS07785 ENOG4105CPC Aldo Keto reductase HA039_RS07795 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HA039_RS07800 ENOG4105CJ1 ABC, transporter HA039_RS07820 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HA039_RS07825 ENOG4105C0X amino acid HA039_RS07830 ENOG4107VEG TrkA-N domain protein HA039_RS07860 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HA039_RS07865 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HA039_RS07870 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HA039_RS07885 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HA039_RS07905 ENOG4106F60 Histidine kinase HA039_RS07910 ENOG4105F44 Two component transcriptional regulator, winged helix family HA039_RS07925 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HA039_RS07955 ENOG4107W53 thymidine kinase HA039_RS07970 ENOG4105CD5 CoA-binding domain protein HA039_RS07975 ENOG410849S phosphocarrier protein (HPr) HA039_RS07980 ENOG4105DRR Transcriptional regulator, GntR family HA039_RS07990 ENOG4107RAN Peptidase, M16 HA039_RS07995 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HA039_RS08015 ENOG4105C0W non-ribosomal peptide synthetase HA039_RS08035 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS08045 ENOG4105CG3 alpha amylase, catalytic region HA039_RS08050 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HA039_RS08055 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HA039_RS08065 ENOG4105CJ1 ABC, transporter HA039_RS08095 ENOG4108MRH transcriptional regulatory protein HA039_RS08100 ENOG4107QN1 sodium solute HA039_RS08110 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS08115 ENOG4105BZU Histidine kinase HA039_RS08125 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HA039_RS08140 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS08145 ENOG4105DRR Transcriptional regulator, GntR family HA039_RS08170 ENOG4105C9U ATP-dependent DNA helicase RecQ HA039_RS08185 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HA039_RS08210 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HA039_RS08230 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HA039_RS08235 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HA039_RS08240 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HA039_RS08275 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HA039_RS08285 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HA039_RS08290 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HA039_RS08300 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HA039_RS08305 ENOG4105D74 hydrolase HA039_RS08310 ENOG4105D29 Helix-turn-helix type 11 domain protein HA039_RS08325 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HA039_RS08335 ENOG4105EB3 Histidine kinase HA039_RS08340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HA039_RS08345 ENOG4105CDA abc transporter atp-binding protein HA039_RS08350 ENOG4107UBR Extracellular solute-binding protein family 3 HA039_RS08355 ENOG4108Q1T ABC transporter HA039_RS08360 ENOG4105DRP amino acid AbC transporter HA039_RS08395 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HA039_RS08420 ENOG4105M2Z protein tyrosine serine phosphatase HA039_RS08425 ENOG4105F27 Major Facilitator HA039_RS08430 ENOG4105KK4 UPF0060 membrane protein HA039_RS08460 ENOG4107QRT dEAD DEAH box helicase HA039_RS08470 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HA039_RS08475 ENOG4105WBV Transcriptional regulator HA039_RS08480 ENOG4105CEV competence damage-inducible protein HA039_RS08490 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HA039_RS08500 ENOG4107QZI cell division protein FtsK HA039_RS08505 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HA039_RS08510 ENOG4105BZU Histidine kinase HA039_RS08545 ENOG4105CN5 Metallo-Beta-Lactamase HA039_RS08550 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HA039_RS08575 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HA039_RS08580 ENOG4105C1V Peptidase, M16 HA039_RS08585 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HA039_RS08590 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HA039_RS08600 ENOG4105EC2 ftsk spoIIIe HA039_RS08635 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HA039_RS08680 ENOG4105DEF Extracellular solute-binding protein, family 5 HA039_RS08685 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HA039_RS08690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS08695 ENOG4105C3U ABC transporter HA039_RS08700 ENOG4108JQ7 (ABC) transporter HA039_RS08710 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HA039_RS08715 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HA039_RS08725 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HA039_RS08740 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HA039_RS08760 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HA039_RS08775 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HA039_RS08780 ENOG4105DZP Membrane-associated zinc metalloprotease HA039_RS08785 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HA039_RS08815 ENOG4105G9B Transcriptional regulator HA039_RS08815 ENOG4105G9B Transcriptional regulator HA039_RS08845 ENOG4105CJP fad dependent oxidoreductase HA039_RS08850 ENOG4105D38 putrescine abc transporter HA039_RS08855 ENOG4105F38 ABC transporter, permease HA039_RS08860 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HA039_RS08865 ENOG4107RUE extracellular solute-binding protein family 1 HA039_RS08885 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HA039_RS08900 ENOG4105BZU Histidine kinase HA039_RS08905 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS08915 ENOG4105C26 Dehydrogenase HA039_RS08925 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HA039_RS08930 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HA039_RS08940 ENOG4105E93 esterase HA039_RS08945 ENOG4108UCS ABC, transporter HA039_RS08950 ENOG4108I5D sulfate abc transporter HA039_RS08960 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HA039_RS08965 ENOG4105KNE Phosphatidate cytidylyltransferase HA039_RS08970 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HA039_RS08975 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HA039_RS08980 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HA039_RS08985 ENOG4105CE9 30S ribosomal protein S2 HA039_RS08990 ENOG4108K5P (LipO)protein HA039_RS09000 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS09015 ENOG41080R2 UPF0102 protein HA039_RS09025 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HA039_RS09030 ENOG4107QYR Signal peptidase i HA039_RS09035 ENOG4107QYR Signal peptidase i HA039_RS09050 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HA039_RS09055 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HA039_RS09060 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HA039_RS09065 ENOG41082KU UPF0109 protein HA039_RS09070 ENOG4105K5M 30s ribosomal protein S16 HA039_RS09080 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HA039_RS09090 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HA039_RS09140 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HA039_RS09145 ENOG4105K4I Scp-like extracellular HA039_RS09150 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HA039_RS09155 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HA039_RS09160 ENOG41084BZ 50S ribosomal protein L32 HA039_RS09175 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HA039_RS09180 ENOG4106H78 methyltransferase HA039_RS09185 ENOG4105CB5 ATP-dependent DNA helicase recG HA039_RS09190 ENOG4105DP4 dak2 domain fusion protein ylov HA039_RS09195 ENOG4105VB9 50S ribosomal protein l28 HA039_RS09200 ENOG4105DWF phosphomethylpyrimidine kinase HA039_RS09220 ENOG4105CPF Cell wall formation (By similarity) HA039_RS09225 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HA039_RS09240 ENOG4105K70 DNA-binding protein HA039_RS09250 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HA039_RS09255 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HA039_RS09260 ENOG41069M3 Transcriptional regulator HA039_RS09290 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HA039_RS09295 ENOG4105ERH Fumarylacetoacetate hydrolase HA039_RS09310 ENOG4105GWZ Roadblock lc7 family protein HA039_RS09330 ENOG4105GWZ Roadblock lc7 family protein HA039_RS09350 ENOG4105D8K carboxyl transferase HA039_RS09355 ENOG4106AM8 polysaccharide lyase family 8 HA039_RS09390 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS09400 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HA039_RS09405 ENOG4105CM2 brancheD-chain amino acid aminotransferase HA039_RS09410 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HA039_RS09415 ENOG4108TM9 integral membrane protein HA039_RS09420 ENOG4105C26 Dehydrogenase HA039_RS09425 ENOG41062BK proline dehydrogenase HA039_RS09440 ENOG4108JQ1 Dehydrogenase HA039_RS09445 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HA039_RS09450 ENOG4108ZP8 Acetolactate synthase small subunit HA039_RS09460 ENOG4105BZU Histidine kinase HA039_RS09470 ENOG4107SET aldo keto reductase HA039_RS09490 ENOG4107SM8 Adenylate Guanylate cyclase HA039_RS09510 ENOG4105EYF MMPL domain protein HA039_RS09525 ENOG4108NNZ chitinase HA039_RS09530 ENOG4107R5R arsenical pump membrane protein HA039_RS09535 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HA039_RS09545 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HA039_RS09550 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HA039_RS09555 ENOG4105BZU Histidine kinase HA039_RS09560 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HA039_RS09595 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HA039_RS09615 ENOG4106TYC homoserine o-acetyltransferase (EC 2.3.1.31) HA039_RS09625 ENOG4105EN6 Membrane HA039_RS09630 ENOG4108JQ7 (ABC) transporter HA039_RS09645 ENOG4108J59 Extracellular solute-binding protein, family 5 HA039_RS09670 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HA039_RS09675 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HA039_RS09680 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HA039_RS09685 ENOG4105EJQ L-serine dehydratase HA039_RS09695 ENOG4106A3M Cytochrome p-450 HA039_RS09710 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS09725 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HA039_RS09740 ENOG4105C57 major facilitator superfamily HA039_RS09765 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS09795 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HA039_RS09800 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HA039_RS09830 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HA039_RS09840 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS09845 ENOG4105BZU Histidine kinase HA039_RS09855 ENOG4105CJ1 ABC, transporter HA039_RS09860 ENOG4105BZ1 (ABC) transporter HA039_RS09865 ENOG4105BZ1 (ABC) transporter HA039_RS09910 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HA039_RS09915 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HA039_RS09920 ENOG4105CG3 alpha amylase, catalytic region HA039_RS09930 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HA039_RS09945 ENOG4105K63 Thioredoxin HA039_RS09950 ENOG4108Z6Z Transcriptional regulator HA039_RS09960 ENOG4105CPC Aldo Keto reductase HA039_RS09965 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HA039_RS10025 ENOG4105CK2 sodium dicarboxylate symporter HA039_RS10035 ENOG4108MRH transcriptional regulatory protein HA039_RS10040 ENOG4105EC2 ftsk spoIIIe HA039_RS10050 ENOG4105CTQ phosphohexokinase HA039_RS10055 ENOG4105C6K Malic enzyme HA039_RS10060 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HA039_RS10150 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS10155 ENOG4105C19 ABC transporter HA039_RS10175 ENOG4105WX6 Membrane HA039_RS10195 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HA039_RS10250 ENOG4106F60 Histidine kinase HA039_RS10255 ENOG4105ETX regulatoR HA039_RS10275 ENOG4105CHU acetyl-coa acetyltransferase HA039_RS10330 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HA039_RS10355 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HA039_RS10365 ENOG4105IIP Membrane HA039_RS10370 ENOG4105BZU Histidine kinase HA039_RS10375 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS10390 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HA039_RS10395 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HA039_RS10400 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HA039_RS10405 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HA039_RS10410 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HA039_RS10415 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HA039_RS10420 ENOG4105ZA1 atp synthase HA039_RS10430 ENOG4105Z3P ATP synthase HA039_RS10440 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HA039_RS10445 ENOG4107ZF2 Phosphatase HA039_RS10455 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HA039_RS10460 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HA039_RS10465 ENOG4105VFB Binds the 23S rRNA (By similarity) HA039_RS10480 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HA039_RS10485 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HA039_RS10490 ENOG4105D6E homoserine dehydrogenase HA039_RS10495 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HA039_RS10500 ENOG4105C75 arginyL-tRNA synthetase HA039_RS10505 ENOG4105ETX regulatoR HA039_RS10520 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS10525 ENOG4105FDF Could be involved in DNA repair (By similarity) HA039_RS10530 ENOG4105DQE DNA ligase HA039_RS10555 ENOG4105KVH Transcriptional regulator HA039_RS10560 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HA039_RS10590 ENOG4105ZXU NLP P60 protein HA039_RS10650 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HA039_RS10665 ENOG4108PYU two-component system response regulator HA039_RS10670 ENOG4105EB3 Histidine kinase HA039_RS10675 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HA039_RS10695 ENOG4105CB2 alcohol dehydrogenase HA039_RS10700 ENOG4105C6K Malic enzyme HA039_RS10715 ENOG4105CDA abc transporter atp-binding protein HA039_RS10735 ENOG4108VEQ Superoxide dismutase HA039_RS10780 ENOG4105ESN nucleotide-binding protein HA039_RS10790 ENOG4105K6H D-cysteine desulfhydrase HA039_RS10820 ENOG4105CBD Diacylglycerol kinase HA039_RS10835 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HA039_RS10840 ENOG4105D17 glycoside hydrolase, family 3 domain protein HA039_RS10860 ENOG4105FDP GntR family transcriptional regulator HA039_RS10875 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HA039_RS10880 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HA039_RS10900 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HA039_RS10915 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HA039_RS10920 ENOG4105WMN AntiSigma factor HA039_RS10925 ENOG4105EMN RNA polymerase sigma factor HA039_RS10935 ENOG4108RAV Conserved protein HA039_RS10945 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HA039_RS10950 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HA039_RS10955 ENOG4105KPY Small multidrug resistance protein HA039_RS10965 ENOG4107TK4 histidinol-phosphate phosphatase HA039_RS11000 ENOG4105DJZ UPF0182 protein HA039_RS11010 ENOG41063PX domain protein HA039_RS11070 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HA039_RS11095 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HA039_RS11175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS11190 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HA039_RS11240 ENOG41081FY multiple antibiotic resistance (MarC)-related HA039_RS11260 ENOG4105D7N magnesium and cobalt transport protein CorA HA039_RS11295 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HA039_RS11300 ENOG4105C0H protease HA039_RS11310 ENOG4105DU6 RNA polymerase HA039_RS11325 ENOG4105CGU Enoyl-CoA hydratase HA039_RS11330 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HA039_RS11340 ENOG4105EEI dihydropteroate synthase HA039_RS11345 ENOG4108URH decarboxylase HA039_RS11350 ENOG4107R4C succinyl-diaminopimelate desuccinylase HA039_RS11370 ENOG4108Z4U Ferredoxin HA039_RS11390 ENOG4108IG5 Transcriptional regulator HA039_RS11405 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HA039_RS11420 ENOG4108M15 ABC transporter HA039_RS11430 ENOG4105BZU Histidine kinase HA039_RS11440 ENOG4108JQ7 (ABC) transporter HA039_RS11445 ENOG4105C3U ABC transporter HA039_RS11450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS11455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HA039_RS11460 ENOG4108J59 Extracellular solute-binding protein, family 5 HA039_RS11465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS11470 ENOG4108J59 Extracellular solute-binding protein, family 5 HA039_RS11485 ENOG4108JQ7 (ABC) transporter HA039_RS11490 ENOG4108JQ7 (ABC) transporter HA039_RS11500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS11515 ENOG4105CI3 gtp-binding protein typa HA039_RS11530 ENOG4105D3W isochorismatase HA039_RS11610 ENOG4105C3G gtp-binding protein HA039_RS11625 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HA039_RS11630 ENOG4105CUB amino acid HA039_RS11635 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HA039_RS11640 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HA039_RS11665 ENOG4107GFK fumarate HA039_RS11670 ENOG4105C9Q fumarate hydratase class II HA039_RS11685 ENOG4105CH6 catalase HA039_RS11690 ENOG4105BZ4 penicillin-binding protein HA039_RS11695 ENOG4105D3R alkyl hydroperoxide reductase HA039_RS11700 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HA039_RS11720 ENOG4108IAB Phoh family HA039_RS11725 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HA039_RS11730 ENOG4105CPC Aldo Keto reductase HA039_RS11755 ENOG4107QKZ Ompa motb domain protein HA039_RS11770 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS11830 ENOG4105C6Z Gluconate HA039_RS11835 ENOG4105KME endoribonuclease L-psp HA039_RS11840 ENOG4108FUF Transcriptional regulator, IclR family HA039_RS11945 ENOG4108WYP Transcriptional regulator HA039_RS11955 ENOG4107R13 MMPL domain protein HA039_RS11970 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HA039_RS11985 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HA039_RS11990 ENOG4108XHQ (2Fe-2S)-binding domain protein HA039_RS12000 ENOG4105CAQ asparagine synthetase HA039_RS12045 ENOG4105C7Z Conserved Protein HA039_RS12090 ENOG4105T1M mycothiol conjugate amidase mca HA039_RS12100 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HA039_RS12115 ENOG4105C7B Threonine dehydratase HA039_RS12120 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HA039_RS12145 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HA039_RS12180 ENOG4105C19 ABC transporter HA039_RS12190 ENOG4105FF0 ErfK YbiS YcfS YnhG HA039_RS12205 ENOG4105C84 Histidine ammonia-lyase HA039_RS12210 ENOG4105KDM Diguanylate cyclase with gaf sensor HA039_RS12215 ENOG4105E39 Enoyl-CoA hydratase HA039_RS12225 ENOG4108QER Adenylate cyclase HA039_RS12235 ENOG4105D8K carboxyl transferase HA039_RS12245 ENOG4107WR6 Maf-like protein HA039_RS12255 ENOG4108JIK carboxylase HA039_RS12260 ENOG4105E98 transcriptional regulator DeoR family HA039_RS12280 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HA039_RS12305 ENOG4105C26 Dehydrogenase HA039_RS12310 ENOG4105C26 Dehydrogenase HA039_RS12330 ENOG4105NAF rna polymerase sigma factor HA039_RS12335 ENOG4108KXV response regulator HA039_RS12340 ENOG41065SU Two-component system sensor kinase HA039_RS12365 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HA039_RS12375 ENOG4107RSM transcriptional regulator HA039_RS12380 ENOG4105D94 Major Facilitator Superfamily HA039_RS12415 ENOG4105UIB (ABC) transporter HA039_RS12420 ENOG4108JQ9 ABC transporter HA039_RS12425 ENOG4105DIH basic membrane HA039_RS12430 ENOG4107RM1 amidohydrolase HA039_RS12440 ENOG4105D2T synthase HA039_RS12445 ENOG4105F0R Cytidylyltransferase HA039_RS12455 ENOG4105K64 Glycosyl transferase, family 2 HA039_RS12465 ENOG4108NIW Leucine export protein LeuE HA039_RS12480 ENOG4108MMM RNA Polymerase HA039_RS12500 ENOG4105DDQ anthranilate synthase HA039_RS12510 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HA039_RS12515 ENOG4106K7D Major facilitator family transporter HA039_RS12520 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HA039_RS12540 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HA039_RS12555 ENOG4105E2D ec 3.2.1.52 HA039_RS12575 ENOG4108J01 L-aspartate oxidase HA039_RS12610 ENOG4108RZE Tetr family transcriptional regulator HA039_RS12620 ENOG4107RN3 metallophosphoesterase HA039_RS12670 ENOG4105C31 Tryptophanyl-tRNA synthetase HA039_RS12680 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HA039_RS12685 ENOG4105C8Y Acetylornithine aminotransferase HA039_RS12690 ENOG4106032 Glutathionylspermidine synthase HA039_RS12705 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HA039_RS12710 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HA039_RS12735 ENOG4105MUA Resistance protein HA039_RS12745 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HA039_RS12755 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HA039_RS12760 ENOG4105W8D rdd domain containing protein HA039_RS12765 ENOG4105DC1 bifunctional purine biosynthesis protein purh HA039_RS12795 ENOG4105CMV Succinyl-CoA synthetase subunit beta HA039_RS12800 ENOG4105DEG Vwa containing coxe family protein HA039_RS12805 ENOG4105RD5 HA039_RS12810 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HA039_RS12840 ENOG4105DR5 peptidase HA039_RS12875 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS12915 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HA039_RS12935 ENOG4105C26 Dehydrogenase HA039_RS12945 ENOG4107TPY serine threonine protein kinase HA039_RS12960 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HA039_RS12965 ENOG4107QQG Dehydrogenase HA039_RS12975 ENOG4107QVP Dehydrogenase HA039_RS12985 ENOG4108MMM RNA Polymerase HA039_RS13000 ENOG4105DND Transcriptional regulator HA039_RS13010 ENOG4105E3B Multicopper oxidase HA039_RS13015 ENOG4105EMU Dehydrogenase HA039_RS13045 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HA039_RS13105 ENOG4105ESF Peptidoglycan binding domain protein HA039_RS13110 ENOG4105CHP RNA polymerase HA039_RS13120 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HA039_RS13155 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HA039_RS13185 ENOG4108097 ATP-binding protein HA039_RS13190 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HA039_RS13195 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HA039_RS13205 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HA039_RS13210 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HA039_RS13230 ENOG4105CS9 pantothenic acid kinase HA039_RS13235 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HA039_RS13240 ENOG4108UJD 30S ribosomal protein S9 HA039_RS13245 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HA039_RS13250 ENOG4105C5H ABC transporter HA039_RS13270 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HA039_RS13275 ENOG4108ZT0 50S ribosomal protein l17 HA039_RS13280 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HA039_RS13285 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HA039_RS13290 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HA039_RS13300 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HA039_RS13310 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HA039_RS13315 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HA039_RS13320 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HA039_RS13325 ENOG410849U 50S ribosomal protein L30 HA039_RS13330 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HA039_RS13335 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HA039_RS13340 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HA039_RS13345 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HA039_RS13355 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HA039_RS13360 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HA039_RS13365 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HA039_RS13370 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HA039_RS13375 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HA039_RS13380 ENOG41082SA 50s ribosomal protein l29 HA039_RS13385 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HA039_RS13390 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HA039_RS13395 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HA039_RS13400 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HA039_RS13405 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HA039_RS13410 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HA039_RS13415 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HA039_RS13420 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HA039_RS13425 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HA039_RS13485 ENOG4105EYF MMPL domain protein HA039_RS13500 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HA039_RS13505 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HA039_RS13510 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HA039_RS13515 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HA039_RS13520 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HA039_RS13530 ENOG4108VZM 50s ribosomal protein L10 HA039_RS13535 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HA039_RS13540 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HA039_RS13545 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HA039_RS13570 ENOG4107R4N Cell wall formation (By similarity) HA039_RS13590 ENOG410900P UPF0336 protein HA039_RS13595 ENOG4105WDJ 50S ribosomal protein L33 HA039_RS13610 ENOG4105DZC cytosine deaminase HA039_RS13630 ENOG4108VPT UPF0234 protein HA039_RS13635 ENOG4105CF1 Alkylated DNA repair protein HA039_RS13650 ENOG410901E Membrane HA039_RS13655 ENOG4105D0M Protease HtpX homolog HA039_RS13660 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13665 ENOG4105C8S subunit m HA039_RS13670 ENOG4105D65 subunit l HA039_RS13675 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13690 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HA039_RS13700 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13705 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HA039_RS13725 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HA039_RS13730 ENOG4105DQU oxidoreductase, subunit beta HA039_RS13735 ENOG4105KVH Transcriptional regulator HA039_RS13740 ENOG4105ECR NmrA family HA039_RS13755 ENOG4105KVH Transcriptional regulator HA039_RS13760 ENOG41084I7 Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures HA039_RS13765 ENOG4105IIU Aminopeptidase HA039_RS13770 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HA039_RS13795 ENOG4105ERH Fumarylacetoacetate hydrolase HA039_RS13830 ENOG4105E90 ABC transporter HA039_RS13835 ENOG4108IJ8 ABC transporter HA039_RS13840 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13850 ENOG4105D65 subunit l HA039_RS13855 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13860 ENOG41087XN oxidoreductase HA039_RS13865 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13870 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HA039_RS13875 ENOG4108IEH NADH dehydrogenase subunit g HA039_RS13880 ENOG4107QIZ NADH dehydrogenase HA039_RS13890 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13895 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HA039_RS13900 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS13920 ENOG4105EQ2 LysR family Transcriptional regulator HA039_RS13940 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HA039_RS13950 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HA039_RS13960 ENOG4105EV6 Pfam:DUF178 HA039_RS13965 ENOG4105VEQ Cold shock protein HA039_RS13980 ENOG4105DVY radical SAM domain protein HA039_RS13985 ENOG4105DQ4 alcohol dehydrogenase HA039_RS13995 ENOG4105CHR reductase HA039_RS14015 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HA039_RS14045 ENOG4105BZU Histidine kinase HA039_RS14050 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS14060 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HA039_RS14070 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HA039_RS14075 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HA039_RS14090 ENOG4105CRE cytochrome C HA039_RS14095 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HA039_RS14100 ENOG4107QIV Cytochrome c biogenesis protein HA039_RS14115 ENOG4108RH7 phosphoglycerate mutase HA039_RS14120 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HA039_RS14135 ENOG4105K64 Glycosyl transferase, family 2 HA039_RS14180 ENOG4105G6Z alkaline phosphatase HA039_RS14185 ENOG4105CTK cobaltochelatase, cobn subunit HA039_RS14195 ENOG41081F0 Precorrin-8x methylmutase HA039_RS14220 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HA039_RS14250 ENOG4105E0Y RtcB Protein HA039_RS14270 ENOG4105DK7 lysyl-tRNA synthetase HA039_RS14275 ENOG4105C75 arginyL-tRNA synthetase HA039_RS14320 ENOG4105D52 delta-aminolevulinic acid dehydratase HA039_RS14325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HA039_RS14330 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HA039_RS14335 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HA039_RS14340 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HA039_RS14390 ENOG4105DGU Histone deacetylase HA039_RS14400 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HA039_RS14420 ENOG4105C31 Tryptophanyl-tRNA synthetase HA039_RS14430 ENOG4105II7 pyrroline-5-carboxylate reductase HA039_RS14445 ENOG4105CJ1 ABC, transporter HA039_RS14480 ENOG4105C01 Dihydroxy-acid dehydratase HA039_RS14490 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HA039_RS14495 ENOG4107R33 ppx gppa phosphatase HA039_RS14500 ENOG4108JWX HA039_RS14510 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HA039_RS14515 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HA039_RS14520 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HA039_RS14550 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HA039_RS14560 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HA039_RS14570 ENOG4105CEN a g-specific adenine glycosylase HA039_RS14575 ENOG4105NAF rna polymerase sigma factor HA039_RS14580 ENOG41075QH Lipoprotein CseA HA039_RS14585 ENOG4108PYU two-component system response regulator HA039_RS14590 ENOG4108FKE two-component system sensor kinase HA039_RS14605 ENOG4108IG5 Transcriptional regulator HA039_RS14610 ENOG4105DR5 peptidase HA039_RS14650 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HA039_RS14660 ENOG4108IYU L-aspartate oxidase HA039_RS14665 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HA039_RS14680 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS14695 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS14705 ENOG4108HQR Glycine betaine HA039_RS14710 ENOG4105E90 ABC transporter HA039_RS14715 ENOG4105E90 ABC transporter HA039_RS14725 ENOG4105EEI dihydropteroate synthase HA039_RS14740 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HA039_RS14750 ENOG4105EUJ GTP cyclohydrolase i HA039_RS14760 ENOG4108UGV hypoxanthine phosphoribosyltransferase HA039_RS14765 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HA039_RS14780 ENOG4105F0N pyrophosphate phospho-hydrolase HA039_RS14790 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HA039_RS14800 ENOG4105CVK Glutamate decarboxylase HA039_RS14820 ENOG4105C26 Dehydrogenase HA039_RS14840 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HA039_RS14850 ENOG4105NRA 50s ribosomal protein l31 type b HA039_RS14855 ENOG4105W0E 50S ribosomal protein L33 HA039_RS14860 ENOG4105KDC 50s ribosomal protein l28 HA039_RS14865 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HA039_RS14875 ENOG4108UW5 maltose o-acetyltransferase HA039_RS14885 ENOG4105C2M dna polymerase I HA039_RS14905 ENOG4105K8R UPF0145 protein HA039_RS14915 ENOG4105D17 glycoside hydrolase, family 3 domain protein HA039_RS14930 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HA039_RS14955 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HA039_RS14985 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HA039_RS15010 ENOG4106JDR secreted HA039_RS15015 ENOG4105C6E dna polymerase iii HA039_RS15030 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HA039_RS15040 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HA039_RS15055 ENOG4105WN5 stage II sporulation protein HA039_RS15115 ENOG4107B2H carbonic anhydrase HA039_RS15120 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HA039_RS15125 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HA039_RS15135 ENOG4105D74 hydrolase HA039_RS15165 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HA039_RS15175 ENOG4105KME endoribonuclease L-psp HA039_RS15205 ENOG4105BZ4 penicillin-binding protein HA039_RS15280 ENOG4106F1P AAA ATPase, central domain protein HA039_RS15300 ENOG4105EC2 ftsk spoIIIe HA039_RS15325 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HA039_RS15335 ENOG4105BZ1 (ABC) transporter HA039_RS15360 ENOG4105NAF rna polymerase sigma factor HA039_RS15370 ENOG4105CFH Aspartokinase HA039_RS15395 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HA039_RS15400 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HA039_RS15415 ENOG4105CKK Glycosyl transferase, family 2 HA039_RS15420 ENOG4105DRR Transcriptional regulator, GntR family HA039_RS15430 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HA039_RS15450 ENOG4108YYD acetyltransferase HA039_RS15475 ENOG4105VUF Transcriptional regulator HA039_RS15480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HA039_RS15530 ENOG4105DJ2 Major Facilitator Superfamily HA039_RS15545 ENOG41082A2 Alpha beta hydrolase HA039_RS15570 ENOG41069M3 Transcriptional regulator HA039_RS15580 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HA039_RS15595 ENOG4108Z6Z Transcriptional regulator HA039_RS15615 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS15620 ENOG4105BZU Histidine kinase HA039_RS15630 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HA039_RS15635 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HA039_RS15660 ENOG4105C87 Aminotransferase class I and II HA039_RS15665 ENOG4107RCW fructose-bisphosphate aldolase HA039_RS15670 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HA039_RS15685 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HA039_RS15715 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HA039_RS15740 ENOG4105KNI merR family transcriptional Regulator HA039_RS15745 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HA039_RS15750 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HA039_RS15755 ENOG4105CFG Acts as a chaperone (By similarity) HA039_RS15765 ENOG4105DF6 Fe-S oxidoreductase HA039_RS15775 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HA039_RS15780 ENOG4105DHP deoxycytidine triphosphate deaminase HA039_RS15810 ENOG4105EX0 alpha-galactosidase HA039_RS15815 ENOG4105ECQ AraC Family Transcriptional Regulator HA039_RS15870 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HA039_RS15945 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HA039_RS15985 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HA039_RS16035 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HA039_RS16060 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HA039_RS16085 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HA039_RS16105 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS16130 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HA039_RS16135 ENOG4105EHG Permease protein HA039_RS16140 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HA039_RS16175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS16180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HA039_RS16185 ENOG4108J59 Extracellular solute-binding protein, family 5 HA039_RS16205 ENOG4106NZI LysR family Transcriptional regulator HA039_RS16275 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HA039_RS16290 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HA039_RS16295 ENOG4107W9I Creatinine amidohydrolase HA039_RS16300 ENOG4107QJN gtp cyclohydrolase ii HA039_RS16305 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS16355 ENOG4105DZ6 Band 7 protein HA039_RS16375 ENOG4108MES Periplasmic binding protein HA039_RS16510 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HA039_RS16515 ENOG4108UZX fmn reductase HA039_RS16575 ENOG4105EM2 membrane HA039_RS16610 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HA039_RS16620 ENOG4105C9M aspartyl-trna synthetase HA039_RS16635 ENOG4105EUB pirin domain protein HA039_RS16645 ENOG4105CSU acyl-Coa dehydrogenase HA039_RS16650 ENOG4105DFM M18 family aminopeptidase HA039_RS16700 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HA039_RS16705 ENOG4105CPP Dehydrogenase, E1 component HA039_RS16735 ENOG4107QPV Serine Threonine protein kinase HA039_RS16750 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HA039_RS16770 ENOG4107SVH Potassium channel protein HA039_RS16785 ENOG4107QSN dihydrolipoamide acetyltransferase HA039_RS16805 ENOG4108IG5 Transcriptional regulator HA039_RS16810 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HA039_RS16835 ENOG41085GJ domain protein HA039_RS16850 ENOG4105KVH Transcriptional regulator HA039_RS16855 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HA039_RS16870 ENOG4105TV9 FHA Domain-Containing protein HA039_RS16875 ENOG4105HZM Fha domain containing protein HA039_RS16890 ENOG4105CJN penicillin-binding protein HA039_RS16900 ENOG4108RN7 integral membrane protein HA039_RS16905 ENOG4108U4N (sortase) family HA039_RS16925 ENOG4105ZJT Cell division protein CrgA HA039_RS16955 ENOG4105CH7 arginosuccinase HA039_RS16965 ENOG4105CPF Cell wall formation (By similarity) HA039_RS16975 ENOG4105CH7 arginosuccinase HA039_RS16985 ENOG4108UAJ Transcriptional regulator HA039_RS17000 ENOG4108UGD Serine Threonine protein kinase HA039_RS17035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HA039_RS17045 ENOG4105K7N UPF0232 protein HA039_RS17050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HA039_RS17055 ENOG4108J5G 6-phosphogluconate dehydrogenase HA039_RS17060 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HA039_RS17070 ENOG41084CH 50S ribosomal protein l34 HA039_RS17080 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HA039_RS17085 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HA039_RS17095 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HA039_RS17100 ENOG4107QJE Chromosome Partitioning Protein HA039_RS17115 ENOG4105K63 Thioredoxin HA039_RS17120 ENOG4105C3M thioredoxin reductase HA039_RS17135 ENOG4105D9P serine threonine protein kinase HA039_RS17150 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HA039_RS17170 ENOG4105BZ4 penicillin-binding protein HA039_RS17185 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) HA039_RS17195 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HA039_RS17200 ENOG4107YH6 single-stranded DNA-binding protein HA039_RS17205 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HA039_RS17210 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HA039_RS17220 ENOG4105CDU Replicative dna helicase HA039_RS17280 ENOG4105C28 cystathionine HA039_RS17285 ENOG4105KJF protein tyrosine phosphatase HA039_RS17290 ENOG41082T9 Membrane HA039_RS17295 ENOG4106048 Cupin 2, conserved barrel domain protein HA039_RS17320 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HA039_RS17335 ENOG4107P2S Transcriptional regulator HA039_RS17340 ENOG4105CIH Imidazole acetol-phosphate transaminase HA039_RS17345 ENOG4105C4M (Ubiquinol oxidase) subunit I HA039_RS17350 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HA039_RS17355 ENOG4108JJ9 ABC, transporter HA039_RS17365 ENOG4105DQF Hydrolase HA039_RS17370 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HA039_RS17390 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HA039_RS17445 ENOG410667J hydrolase HA039_RS17450 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HA039_RS17455 ENOG4105CQC Prephenate dehydratase HA039_RS17460 ENOG4105DBE peroxidase HA039_RS17465 ENOG4105JDN Copper resistance protein HA039_RS17470 ENOG41080T7 secreted protein HA039_RS17495 ENOG4107T6F Xaa-Pro aminopeptidase HA039_RS17515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HA039_RS17590 ENOG4105NAF rna polymerase sigma factor HA039_RS17595 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS17600 ENOG4108UXN response regulator HA039_RS17655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HA039_RS17665 ENOG410905P Pyridoxamine 5-phosphate HA039_RS17670 ENOG4108YYC ycei family HA039_RS17690 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS17695 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS17700 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HA039_RS17715 ENOG4108Z6B deaminase HA039_RS17730 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HA039_RS17755 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HA039_RS17835 ENOG4105C0A alcohol dehydrogenase HA039_RS17870 ENOG4105CJA serine threonine protein kinase HA039_RS17890 ENOG4105D64 Mechanosensitive ion channel HA039_RS17910 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HA039_RS17915 ENOG4105NI8 Cytosine-specific methyltransferase HA039_RS17925 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HA039_RS17955 ENOG4105EWK phytoene HA039_RS18025 ENOG4105C12 Phosphoribosylglycinamide synthetase HA039_RS18045 ENOG4105C8V SAICAR synthetase HA039_RS18055 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS18090 ENOG410839H phosphoribosylformylglycinamidine synthase HA039_RS18095 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HA039_RS18100 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HA039_RS18135 ENOG4105CXB phosphoribosylaminoimidazole synthetase HA039_RS18150 ENOG4108TAC HA039_RS18165 ENOG4105CQ7 ATP-dependent helicase HA039_RS18200 ENOG41083TI Protein CrcB homolog HA039_RS18210 ENOG4105C1J atp-dependent rna helicase HA039_RS18240 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HA039_RS18280 ENOG4107SET aldo keto reductase HA039_RS18290 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HA039_RS18295 ENOG4105D5U fad dependent oxidoreductase HA039_RS18410 ENOG4105E4C Lytic transglycosylase catalytic HA039_RS18415 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HA039_RS18430 ENOG4105DNP FAD linked oxidase domain protein HA039_RS18450 ENOG4105VPX protein, conserved in bacteria HA039_RS18460 ENOG4105CJ3 phosphate transporter HA039_RS18465 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HA039_RS18495 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HA039_RS18525 ENOG4105C8Y Acetylornithine aminotransferase HA039_RS18550 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HA039_RS18555 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HA039_RS18605 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HA039_RS18610 ENOG4105CGH 5'-nucleotidase HA039_RS18620 ENOG41062D9 Histidine kinase HA039_RS18630 ENOG4105C0H protease HA039_RS18635 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS18640 ENOG4107NHD transcriptional regulator HA039_RS18665 ENOG4105KHC sulfurtransferase HA039_RS18670 ENOG4105PKJ carbohydrate binding HA039_RS18710 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HA039_RS18715 ENOG41090R7 Ferric uptake HA039_RS18720 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HA039_RS18725 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HA039_RS18740 ENOG4105HHS UPF0256 protein HA039_RS18785 ENOG410719E cytochrome p450 HA039_RS18805 ENOG4105NAF rna polymerase sigma factor HA039_RS18810 ENOG4105F27 Major Facilitator HA039_RS18815 ENOG4105KV4 Transcriptional regulator HA039_RS18820 ENOG4108Z6Z Transcriptional regulator HA039_RS18830 ENOG4105CHR reductase HA039_RS18835 ENOG4105EEM helicase HA039_RS18865 ENOG4105JVQ RNA Polymerase HA039_RS18900 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HA039_RS18905 ENOG4108YZJ Pfam:DUF2596 HA039_RS18945 ENOG4105CPC Aldo Keto reductase HA039_RS18950 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HA039_RS18970 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HA039_RS19040 ENOG4105BZU Histidine kinase HA039_RS19060 ENOG4108VJ1 Transcriptional regulator (CarD family HA039_RS19065 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HA039_RS19070 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HA039_RS19080 ENOG4105C8N cysteinyl-tRNA synthetase HA039_RS19085 ENOG4105C2N RNA methyltransferase TrmH family group 3 HA039_RS19130 ENOG4105CHR reductase HA039_RS19175 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid HA039_RS19210 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HA039_RS19225 ENOG4105CJP fad dependent oxidoreductase HA039_RS19290 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HA039_RS19300 ENOG4105BZU Histidine kinase HA039_RS19320 ENOG4105CE4 GlcNAc 6-P deacetylase HA039_RS19340 ENOG4105VNY Trehalose 6-phosphate phosphatase HA039_RS19355 ENOG4105C3Q Glycosyl transferase, family 2 HA039_RS19375 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HA039_RS19395 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HA039_RS19400 ENOG4106KNT transcriptional regulator HA039_RS19455 ENOG4105EEM helicase HA039_RS19470 ENOG4105CFI type iii restriction protein res subunit HA039_RS19490 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HA039_RS19495 ENOG4105ECQ AraC Family Transcriptional Regulator HA039_RS19505 ENOG4105TVJ transport system, permease HA039_RS19510 ENOG4105DQ5 transport system permease protein HA039_RS19525 ENOG4105VEQ Cold shock protein HA039_RS19530 ENOG4105E63 Pfam:DUF178 HA039_RS19535 ENOG4108UIH futalosine nucleosidase HA039_RS19545 ENOG4108N0W Major Facilitator superfamily HA039_RS19600 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HA039_RS19620 ENOG4105E8G Major facilitator Superfamily HA039_RS19635 ENOG4105CPC Aldo Keto reductase HA039_RS19700 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HA039_RS19710 ENOG4105CQB FAD linked oxidase domain protein HA039_RS19715 ENOG4106NZI LysR family Transcriptional regulator HA039_RS19745 ENOG4107QX3 carboxylase HA039_RS19760 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS19780 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HA039_RS19795 ENOG4107B2H carbonic anhydrase HA039_RS19800 ENOG4108SU4 UPF0309 protein HA039_RS19810 ENOG4108XEP Alpha Beta Hydrolase Fold protein HA039_RS19845 ENOG4108R6W Transcriptional regulator, ARAC family HA039_RS19850 ENOG4107S9F NmrA family HA039_RS19880 ENOG41082AN stage II sporulation protein HA039_RS19910 ENOG4105H3G oxidoreductase HA039_RS19925 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HA039_RS19930 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HA039_RS19940 ENOG4108762 serine threonine protein kinase HA039_RS19945 ENOG4108KPJ rna polymerase sigma factor HA039_RS19950 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HA039_RS19965 ENOG4105F0K SARP family transcriptional regulator HA039_RS20010 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HA039_RS20050 ENOG4105DZ1 carboxypeptidase HA039_RS20090 ENOG4105D5G Transposase HA039_RS20100 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HA039_RS20120 ENOG4107RCI amp-dependent synthetase and ligase HA039_RS20145 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HA039_RS20170 ENOG4105GFG DUF218 domain HA039_RS20190 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HA039_RS20200 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HA039_RS20215 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HA039_RS20225 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HA039_RS20230 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HA039_RS20240 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HA039_RS20245 ENOG4108RIR Molybdenum cofactor biosynthesis protein HA039_RS20325 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HA039_RS20330 ENOG4105D3Q Sugar transferase HA039_RS20340 ENOG4105CJR Integral membrane protein (MviN HA039_RS20350 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HA039_RS20375 ENOG4105S2J secreted protein HA039_RS20395 ENOG4108KGH TRANSCRIPTIONal HA039_RS20480 ENOG4105F95 Monooxygenase HA039_RS20490 ENOG4108R85 Short chain dehydrogenase HA039_RS20510 ENOG4105EYF MMPL domain protein HA039_RS20520 ENOG4105CIF Ornithine Cyclodeaminase HA039_RS20530 ENOG4105DDQ anthranilate synthase HA039_RS20535 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HA039_RS20545 ENOG4108I0Q anthranilate phosphoribosyltransferase HA039_RS20585 ENOG4105CHR reductase HA039_RS20620 ENOG4105DBV ornithine carbamoyltransferase HA039_RS20690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS20695 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS20715 ENOG4105F0K SARP family transcriptional regulator HA039_RS20725 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HA039_RS20735 ENOG4108JJB ABC transporter HA039_RS20825 ENOG4105F8V Hydrolase, tatD family HA039_RS20840 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HA039_RS20855 ENOG4105C5H ABC transporter HA039_RS20895 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HA039_RS20905 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS20910 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HA039_RS20915 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HA039_RS20925 ENOG4108RZE Tetr family transcriptional regulator HA039_RS20935 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HA039_RS20945 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HA039_RS20950 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HA039_RS20955 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HA039_RS20960 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HA039_RS20975 ENOG4105BZU Histidine kinase HA039_RS21005 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HA039_RS21010 ENOG4108KEZ Dehydrogenase HA039_RS21025 ENOG4105C0R drug resistance transporter emrb qaca subfamily HA039_RS21030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS21035 ENOG4107RBB ABC transporter, permease HA039_RS21055 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HA039_RS21125 ENOG4105D9P serine threonine protein kinase HA039_RS21145 ENOG4106A3M Cytochrome p-450 HA039_RS21150 ENOG4105MS9 Resuscitation-promoting factor HA039_RS21160 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HA039_RS21185 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HA039_RS21190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS21195 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS21220 ENOG4105CHU acetyl-coa acetyltransferase HA039_RS21305 ENOG4105CGP Urocanate hydratase HA039_RS21320 ENOG4105CI2 imidazolone-5-propionate hydrolase HA039_RS21360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HA039_RS21365 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HA039_RS21370 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS21385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HA039_RS21390 ENOG41065SU Two-component system sensor kinase HA039_RS21415 ENOG4105BZU Histidine kinase HA039_RS21420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HA039_RS21430 ENOG4105C6Y Udp-glucose 6-dehydrogenase HA039_RS21440 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HA039_RS21460 ENOG4108KGH TRANSCRIPTIONal HA039_RS21465 ENOG4108S4H thioesterase Superfamily protein HA039_RS21470 ENOG4108KGH TRANSCRIPTIONal HA039_RS21475 ENOG4108KGH TRANSCRIPTIONal HA039_RS21480 ENOG4107TB5 TRANSCRIPTIONal HA039_RS21500 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HA039_RS21540 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HA039_RS21560 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HA039_RS21565 ENOG4107RGC Glycosyl transferase, family 2 HA039_RS21595 ENOG4105DAA L-lactate HA039_RS21600 ENOG4107QKV phosphomannomutase HA039_RS21605 ENOG4105W49 UPF0434 protein HA039_RS21615 ENOG4105EIP mannose-6-phosphate isomerase HA039_RS21625 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HA039_RS21665 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HA039_RS21670 ENOG4108WQ6 secreted protein HA039_RS21685 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HA039_RS21690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HA039_RS21695 ENOG4105BZU Histidine kinase HA039_RS21700 ENOG4105G3P Lipoprotein lpqB HA039_RS21710 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HA039_RS21715 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS21720 ENOG4105T0Z Conserved Protein HA039_RS21730 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HA039_RS21750 ENOG4105C7I Dehydrogenase HA039_RS21775 ENOG4105K64 Glycosyl transferase, family 2 HA039_RS21780 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HA039_RS21795 ENOG4105EC2 ftsk spoIIIe HA039_RS21800 ENOG4108UGD Serine Threonine protein kinase HA039_RS21805 ENOG4108QVN serine threonine protein kinase HA039_RS21810 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HA039_RS21825 ENOG4105CAK Cell division ATP-binding protein ftsE HA039_RS21835 ENOG4105CN1 protease HA039_RS21840 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HA039_RS21855 ENOG4105EQ2 LysR family Transcriptional regulator HA039_RS21910 ENOG4105EEM helicase HA039_RS21920 ENOG4108426 dNA-binding protein HA039_RS21925 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HA039_RS21930 ENOG4108UJU UPF0301 protein HA039_RS21955 ENOG4105E2D ec 3.2.1.52 HA039_RS21970 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HA039_RS22005 ENOG4105C0R drug resistance transporter emrb qaca subfamily HA039_RS22045 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HA039_RS22055 ENOG4105CQB FAD linked oxidase domain protein HA039_RS22060 ENOG4105KF0 sporulation and cell division protein, SsgA HA039_RS22090 ENOG4108RWI nicotinamidase HA039_RS22105 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HA039_RS22115 ENOG4105C85 amino acid HA039_RS22130 ENOG4105EHG Permease protein HA039_RS22135 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HA039_RS22155 ENOG4108RQ5 Beta-lactamase domain-containing protein HA039_RS22170 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HA039_RS22180 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HA039_RS22220 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HA039_RS22225 ENOG4105BZ4 penicillin-binding protein HA039_RS22240 ENOG4108IUW ABC transporter HA039_RS22255 ENOG4106BRA Membrane HA039_RS22285 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HA039_RS22345 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HA039_RS22355 ENOG41090KN UPF0303 protein HA039_RS22360 ENOG4105D9R oxidoreductase HA039_RS22390 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HA039_RS22410 ENOG4108M1A Chitin-binding protein HA039_RS22420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS22440 ENOG4108TCJ secreted hydrolase HA039_RS22450 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HA039_RS22465 ENOG4105DEN Luciferase family HA039_RS22565 ENOG4105BZU Histidine kinase HA039_RS22610 ENOG4108ZM9 phosphoglycerate mutase HA039_RS22655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HA039_RS22660 ENOG410804D Sensor Signal Transduction Histidine Kinase HA039_RS22665 ENOG4107SMB hydrolase Family 5 HA039_RS22705 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HA039_RS22710 ENOG4105ECQ AraC Family Transcriptional Regulator HA039_RS22730 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HA039_RS22745 ENOG4105E2D ec 3.2.1.52 HA039_RS22750 ENOG4105GFG DUF218 domain HA039_RS22765 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS22770 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HA039_RS22780 ENOG4107QX3 carboxylase HA039_RS22790 ENOG4108XFF HA039_RS22795 ENOG4105C29 acyl-CoA thioesterase HA039_RS22805 ENOG4108YYH Nadph-dependent fmn reductase HA039_RS22815 ENOG41060W2 glyoxylate carboligase HA039_RS22880 ENOG4105C7H Helicase, RecD TraA family HA039_RS22905 ENOG4107UH8 sugar kinase HA039_RS22915 ENOG4105DH8 myo-inositol catabolism HA039_RS22920 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HA039_RS22925 ENOG4105C26 Dehydrogenase HA039_RS22935 ENOG4105KVH Transcriptional regulator HA039_RS22945 ENOG4105CR4 methylisocitrate lyase HA039_RS22955 ENOG4105DHU Bile acid HA039_RS22965 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HA039_RS23025 ENOG4108SZE gCN5-related N-acetyltransferase HA039_RS23075 ENOG4107R7Y intracellular protease Pfpi family HA039_RS23095 ENOG4105VHU single-stranded DNA-binding protein HA039_RS23130 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HA039_RS23160 ENOG4105CT1 (ABC) transporter HA039_RS23175 ENOG4105F8D glycoside hydrolase family 4 HA039_RS23180 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HA039_RS23195 ENOG4105E2R ROK family HA039_RS23200 ENOG4105D8X mechanosensitive ion channel HA039_RS23230 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HA039_RS23260 ENOG4105I6B RNA polymerase HA039_RS23270 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HA039_RS23290 ENOG4105MC2 DSBA oxidoreductase HA039_RS23295 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HA039_RS23330 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HA039_RS23335 ENOG4107S91 Sodium hydrogen exchanger HA039_RS23340 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS23365 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HA039_RS23370 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HA039_RS23375 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HA039_RS23380 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HA039_RS23390 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HA039_RS23395 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HA039_RS23405 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HA039_RS23410 ENOG4105DFF Rod shape-determining protein mreb HA039_RS23425 ENOG4105CJN penicillin-binding protein HA039_RS23430 ENOG4105CNI cell division protein FtsW HA039_RS23485 ENOG4105C03 ribonuclease HA039_RS23490 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HA039_RS23495 ENOG4105K46 50S ribosomal protein l27 HA039_RS23500 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HA039_RS23520 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HA039_RS23530 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HA039_RS23545 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HA039_RS23550 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HA039_RS23560 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HA039_RS23575 ENOG4105D0M Protease HtpX homolog HA039_RS23590 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HA039_RS23605 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HA039_RS23640 ENOG4107QIZ NADH dehydrogenase HA039_RS23650 ENOG4105C8T Leucyl-tRNA synthetase HA039_RS23660 ENOG4105EPR degv family HA039_RS23665 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HA039_RS23670 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HA039_RS23675 ENOG4108YYC ycei family HA039_RS23690 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HA039_RS23695 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HA039_RS23735 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HA039_RS23740 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HA039_RS23755 ENOG4107YU2 histidine triad (hIT) protein HA039_RS23760 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HA039_RS23765 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HA039_RS23775 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HA039_RS23785 ENOG4105MSB protein, conserved in bacteria HA039_RS23795 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HA039_RS23810 ENOG4105D4Y metalloprotease HA039_RS23815 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HA039_RS23825 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HA039_RS23830 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HA039_RS23840 ENOG4105FAV ABC, transporter HA039_RS23845 ENOG4105FDK ABC transporter HA039_RS23850 ENOG4105DSE periplasmic solute binding protein HA039_RS23855 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HA039_RS23870 ENOG4108FN7 Aldo keto reductase HA039_RS23980 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HA039_RS23985 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HA039_RS23990 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HA039_RS24050 ENOG4108UB4 uncharacterized protein ygjQ HA039_RS24060 ENOG4105DEG Vwa containing coxe family protein HA039_RS24065 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HA039_RS24095 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HA039_RS24105 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HA039_RS24150 ENOG4108M8W Monooxygenase HA039_RS24165 ENOG4108UGD Serine Threonine protein kinase HA039_RS24220 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HA039_RS24225 ENOG4108ZHJ Organic hydroperoxide resistance protein HA039_RS24235 ENOG4105EXN Sulfate transport protein CysZ HA039_RS24240 ENOG4105NGS secreted protein HA039_RS24245 ENOG4108R86 Transcriptional regulator HA039_RS24250 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HA039_RS24255 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HA039_RS24270 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HA039_RS24280 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HA039_RS24315 ENOG4105VUF Transcriptional regulator HA039_RS24320 ENOG4105CPC Aldo Keto reductase HA039_RS24350 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HA039_RS24400 ENOG4105DAX Pfam:DUF2983 HA039_RS24445 ENOG4108KPJ rna polymerase sigma factor HA039_RS24450 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HA039_RS24535 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HA039_RS24540 ENOG4107QVI Methyltransferase, type 11 HA039_RS24585 ENOG4108S01 response regulator HA039_RS24590 ENOG4105BZU Histidine kinase HA039_RS24600 ENOG4108M15 ABC transporter HA039_RS24615 ENOG4108MES Periplasmic binding protein HA039_RS24620 ENOG4105EGD dinuclear metal center protein, YbgI family HA039_RS24635 ENOG4108UHU Aldolase HA039_RS24640 ENOG4107XFJ UPF0246 protein HA039_RS24680 ENOG4105DKW ABC transporter HA039_RS24690 ENOG4105HZM Fha domain containing protein HA039_RS24710 ENOG4105JAB phenazine biosynthesis protein, phzf family HA039_RS24720 ENOG4105DGI Alkaline phosphatase HA039_RS24730 ENOG4105C2C drug resistance transporter, Bcr CflA HA039_RS24760 ENOG4106A0S HA039_RS24770 ENOG4105DBE peroxidase HA039_RS24785 ENOG4105EWN Heme oxygenase HA039_RS24820 ENOG4107XZ0 Peptidase M50 HA039_RS24840 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HA039_RS24845 ENOG4105C57 major facilitator superfamily HA039_RS24860 ENOG4105F27 Major Facilitator HA039_RS24865 ENOG4105C4K Nad synthetase HA039_RS24890 ENOG410834F Transcriptional regulator HA039_RS24895 ENOG4105C5F glutamine synthetase HA039_RS24915 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HA039_RS24925 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS24930 ENOG4107FKK extracellular solute-binding protein family 1 HA039_RS24935 ENOG4105D56 permease protein HA039_RS24945 ENOG4105CG3 alpha amylase, catalytic region HA039_RS24985 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS25015 ENOG4107NHD transcriptional regulator HA039_RS25020 ENOG4107R5B glutamine synthetase HA039_RS25040 ENOG4106SPC secreted protein HA039_RS25050 ENOG4105EMN RNA polymerase sigma factor HA039_RS25105 ENOG4105D9P serine threonine protein kinase HA039_RS25150 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HA039_RS25155 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HA039_RS25195 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HA039_RS25215 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HA039_RS25220 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HA039_RS25230 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HA039_RS25235 ENOG4108YZT Adenosylcobinamide kinase HA039_RS25245 ENOG4105C0H protease HA039_RS25255 ENOG4105DXX methyltransferase HA039_RS25280 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS25290 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HA039_RS25310 ENOG4107T4Z adenosine kinase HA039_RS25320 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HA039_RS25325 ENOG4105BZ9 Cytochrome C oxidase, subunit I HA039_RS25330 ENOG4105MCD Part of cytochrome c oxidase, its function is HA039_RS25335 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HA039_RS25345 ENOG4105CCU oxidase (Subunit III) HA039_RS25350 ENOG4107UDY cytochrome C HA039_RS25355 ENOG4107EUI c reductase, iron-sulfur HA039_RS25360 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HA039_RS25365 ENOG4108I0Q anthranilate phosphoribosyltransferase HA039_RS25370 ENOG4105C9B Cysteine desulfurase HA039_RS25395 ENOG4105K4H Nlp p60 protein HA039_RS25415 ENOG4105JNK Glycosyl transferase (Group 1 HA039_RS25435 ENOG4105D0U Arsenite-activated ATPase (ArsA) HA039_RS25445 ENOG4105DKQ ROK family HA039_RS25470 ENOG4105ENE Histidine kinase HA039_RS25475 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS25485 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HA039_RS25495 ENOG4108UQY Iron-storage protein HA039_RS25505 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HA039_RS25515 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HA039_RS25535 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HA039_RS25545 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HA039_RS25560 ENOG4105EWK phytoene HA039_RS25570 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HA039_RS25590 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HA039_RS25600 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HA039_RS25610 ENOG4105CJN penicillin-binding protein HA039_RS25615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HA039_RS25625 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HA039_RS25630 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HA039_RS25640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HA039_RS25650 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HA039_RS25655 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HA039_RS25660 ENOG4105DFA alanine racemase domain protein HA039_RS25665 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HA039_RS25675 ENOG4107VQS DivIVA family HA039_RS25680 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HA039_RS25695 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HA039_RS25735 ENOG4105C0B DNA polymerase III (alpha subunit) HA039_RS25765 ENOG4108Z66 YbaK ebsC protein HA039_RS25785 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HA039_RS25790 ENOG4105CIH Imidazole acetol-phosphate transaminase HA039_RS25795 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HA039_RS25805 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HA039_RS25810 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HA039_RS25815 ENOG4108176 endoribonuclease L-psp HA039_RS25820 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HA039_RS25840 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HA039_RS25845 ENOG4105CRQ synthase (Component I) HA039_RS25865 ENOG4105DK0 Indole-3-glycerol phosphate synthase HA039_RS25875 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HA039_RS25880 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HA039_RS25890 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HA039_RS25900 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HA039_RS25905 ENOG4108RVA ribokinase HA039_RS25925 ENOG41065RQ ADP-ribosylation crystallin J1 HA039_RS25935 ENOG4105CBC glutamate synthase HA039_RS25955 ENOG41090B9 response to stress HA039_RS25960 ENOG4105VEQ Cold shock protein HA039_RS25965 ENOG4105C1J atp-dependent rna helicase HA039_RS26005 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HA039_RS26025 ENOG4105CGH 5'-nucleotidase HA039_RS26055 ENOG4108IV0 ABC, transporter HA039_RS26060 ENOG4105C0Z ABC transporter HA039_RS26065 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HA039_RS26070 ENOG4105C32 Amino acid ABC transporter (Permease) HA039_RS26085 ENOG4105KA0 thioesterase Superfamily protein HA039_RS26105 ENOG4105CQ7 ATP-dependent helicase HA039_RS26110 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HA039_RS26135 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HA039_RS26140 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HA039_RS26165 ENOG4105EBR Carboxylesterase HA039_RS26170 ENOG4105C0D helicase HA039_RS26180 ENOG4106A3M Cytochrome p-450 HA039_RS26195 ENOG4105CHM Aminotransferase HA039_RS26220 ENOG4105D7K pfkb domain protein HA039_RS26225 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HA039_RS26230 ENOG4105E2A Dehydrogenase HA039_RS26235 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HA039_RS26240 ENOG4105BZU Histidine kinase HA039_RS26245 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HA039_RS26285 ENOG4105D7K pfkb domain protein HA039_RS26310 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HA039_RS26315 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HA039_RS26320 ENOG4105CHW UPF0052 protein HA039_RS26325 ENOG4105CIE May be required for sporulation (By similarity) HA039_RS26335 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HA039_RS26340 ENOG4105BZA Phosphoglycerate kinase HA039_RS26345 ENOG4105CP7 Triose-phosphate isomerase HA039_RS26365 ENOG4107QP8 phosphohexose isomerase HA039_RS26380 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HA039_RS26395 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HA039_RS26405 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HA039_RS26445 ENOG4105JRK feS assembly protein SufD HA039_RS26455 ENOG4105C3K feS assembly ATPase SufC HA039_RS26460 ENOG4105C9B Cysteine desulfurase HA039_RS26465 ENOG4108UNV SUF system FeS assembly protein, NifU family HA039_RS26470 ENOG4105VG1 fes assembly suf system protein HA039_RS26475 ENOG410814C multidrug resistance protein HA039_RS26480 ENOG4108RFG Tetr family transcriptional regulator HA039_RS26490 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HA039_RS26495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HA039_RS26515 ENOG4105CHR reductase HA039_RS26540 ENOG4105E9Z Nad-dependent epimerase dehydratase HA039_RS26560 ENOG4105C7N Xanthine uracil vitamin C permease HA039_RS26570 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HA039_RS26575 ENOG4105CJN penicillin-binding protein HA039_RS26580 ENOG4107258 Transcriptional regulator HA039_RS26630 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HA039_RS26635 ENOG4107STF Involved in phosphonate degradation (By similarity) HA039_RS26675 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HA039_RS26690 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HA039_RS26710 ENOG4107W7X Aldolase HA039_RS26735 ENOG4105C5H ABC transporter HA039_RS26745 ENOG4105E39 Enoyl-CoA hydratase HA039_RS26755 ENOG4105VBF alkaline shock protein HA039_RS26805 ENOG4105CHR reductase HA039_RS26810 ENOG4105BZP glycoside hydrolase 15-related HA039_RS26820 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HA039_RS26830 ENOG4105E2A Dehydrogenase HA039_RS26845 ENOG4107QN1 sodium solute HA039_RS26850 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HA039_RS26865 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HA039_RS26880 ENOG4105CHR reductase HA039_RS26885 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HA039_RS26895 ENOG41073TP transcriptional regulator HA039_RS26900 ENOG4105DJ2 Major Facilitator Superfamily HA039_RS26915 ENOG4105EAC phosphoserine phosphatase HA039_RS26920 ENOG4105IDI abc transporter atp-binding protein HA039_RS26930 ENOG4105ENE Histidine kinase HA039_RS26935 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS26955 ENOG4105DKW ABC transporter HA039_RS26980 ENOG4108V1U phospholipid-binding protein HA039_RS26990 ENOG4108VX5 3-methyladenine DNA glycosylase HA039_RS27020 ENOG4105DSU hydrolase HA039_RS27055 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HA039_RS27060 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HA039_RS27075 ENOG4108I0C methyltransferase HA039_RS27080 ENOG4105BZP glycoside hydrolase 15-related HA039_RS27085 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HA039_RS27090 ENOG4108YZ4 nudix hydrolase HA039_RS27100 ENOG4105DCF alanine dehydrogenase HA039_RS27115 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HA039_RS27120 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HA039_RS27125 ENOG4105FE9 pseudouridine synthase HA039_RS27150 ENOG410756H nucleotidyltransferase HA039_RS27165 ENOG4105CAT Cytidine monophosphate kinase HA039_RS27175 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HA039_RS27190 ENOG4108I69 Glycosyl transferases group 1 HA039_RS27210 ENOG410841Q phosphoesterase PA-phosphatase related protein HA039_RS27215 ENOG4105C57 major facilitator superfamily HA039_RS27220 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS27225 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HA039_RS27255 ENOG4106NMR serine protease HA039_RS27295 ENOG4108VQR secreted hydrolase HA039_RS27310 ENOG4108HGY Proline imino-peptidase HA039_RS27325 ENOG4105C0B DNA polymerase III (alpha subunit) HA039_RS27330 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HA039_RS27345 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HA039_RS27360 ENOG4107SQU synthase HA039_RS27370 ENOG4105F1N DNA alkylation repair HA039_RS27375 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HA039_RS27385 ENOG4105DGU Histone deacetylase HA039_RS27395 ENOG4105C57 major facilitator superfamily HA039_RS27405 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HA039_RS27425 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HA039_RS27435 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HA039_RS27450 ENOG4105K64 Glycosyl transferase, family 2 HA039_RS27460 ENOG4108TCJ secreted hydrolase HA039_RS27495 ENOG4105F1J Homogentisate 1,2-dioxygenase HA039_RS27500 ENOG4108SGK Tetr family transcriptional regulator HA039_RS27505 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HA039_RS27505 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HA039_RS27510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HA039_RS27535 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS27575 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HA039_RS27580 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS27585 ENOG4108IG5 Transcriptional regulator HA039_RS27595 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS27605 ENOG4105EQX glucarate dehydratase HA039_RS27620 ENOG4105VG5 Membrane HA039_RS27625 ENOG4105PTV Nudix Hydrolase HA039_RS27630 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein HA039_RS27650 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HA039_RS27660 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HA039_RS27675 ENOG4105D3G Pseudouridine synthase HA039_RS27730 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HA039_RS27760 ENOG4105CPC Aldo Keto reductase HA039_RS27765 ENOG4105DYW oxidoreductase HA039_RS27775 ENOG4105D7N magnesium and cobalt transport protein CorA HA039_RS27795 ENOG4105C8N cysteinyl-tRNA synthetase HA039_RS27810 ENOG4105DIA mandelate racemase muconate lactonizing HA039_RS27825 ENOG4105C2J ABC transporter HA039_RS27830 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HA039_RS27835 ENOG4105JXH GntR family transcriptional regulator HA039_RS27840 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HA039_RS27845 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HA039_RS27850 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HA039_RS27855 ENOG4108K8U Glycerol operon regulatory protein HA039_RS27860 ENOG4105C3R Methionine synthase HA039_RS27870 ENOG4108J59 Extracellular solute-binding protein, family 5 HA039_RS27880 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS27915 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HA039_RS27920 ENOG4105E5F proteasome HA039_RS27925 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HA039_RS27935 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HA039_RS27940 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HA039_RS27945 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS27955 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HA039_RS27990 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HA039_RS27995 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HA039_RS28020 ENOG4105EIG urea carboxylase-associated protein 1 HA039_RS28030 ENOG4105MKU Transcriptional regulator HA039_RS28035 ENOG41065RQ ADP-ribosylation crystallin J1 HA039_RS28065 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HA039_RS28075 ENOG4105CVP deoxyribo-dipyrimidine photolyase HA039_RS28080 ENOG4105RNG membrane HA039_RS28085 ENOG4105K6V RNA polymerase HA039_RS28095 ENOG4105HFS 5'-3' exonuclease HA039_RS28100 ENOG4108IJ7 Glycine betaine HA039_RS28135 ENOG4108Z86 Glutamine amidotransferase HA039_RS28140 ENOG4105CUB amino acid HA039_RS28150 ENOG4105C5F glutamine synthetase HA039_RS28155 ENOG4105C26 Dehydrogenase HA039_RS28205 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HA039_RS28210 ENOG41084BS 50S ribosomal protein L35 HA039_RS28215 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HA039_RS28220 ENOG4108RWN rrna methyltransferase HA039_RS28225 ENOG4105BZU Histidine kinase HA039_RS28230 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HA039_RS28235 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HA039_RS28250 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HA039_RS28260 ENOG4105F32 YngK protein HA039_RS28275 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HA039_RS28280 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HA039_RS28310 ENOG4105T38 integral membrane protein HA039_RS28315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HA039_RS28325 ENOG4105C9U ATP-dependent DNA helicase RecQ HA039_RS28330 ENOG41086D8 Transcriptional regulator HA039_RS28335 ENOG4108N5B 2-phosphosulfolactate phosphatase HA039_RS28340 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HA039_RS28345 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HA039_RS28355 ENOG4105C8Y Acetylornithine aminotransferase HA039_RS28360 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HA039_RS28365 ENOG4108RVA ribokinase HA039_RS28370 ENOG4108KD5 ADP-ribosylation crystallin J1 HA039_RS28375 ENOG4105FDP GntR family transcriptional regulator HA039_RS28390 ENOG4105CDH Citrulline--aspartate ligase HA039_RS28395 ENOG4105CH7 arginosuccinase HA039_RS28405 ENOG4105RJZ Transcriptional regulator HA039_RS28410 ENOG4105C57 major facilitator superfamily HA039_RS28415 ENOG4105CEY Amp-dependent synthetase and ligase HA039_RS28450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HA039_RS28455 ENOG4108UMI ABC transporter, permease HA039_RS28460 ENOG4105D01 (LipO)protein HA039_RS28475 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HA039_RS28480 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HA039_RS28535 ENOG4105CRQ synthase (Component I) HA039_RS28545 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HA039_RS28570 ENOG4105KF0 sporulation and cell division protein, SsgA HA039_RS28595 ENOG4108JDX DNA polymerase iii, epsilon subunit HA039_RS28610 ENOG4105C22 threonyL-tRNA synthetase HA039_RS28635 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HA039_RS28640 ENOG4105E2K Glycosyl transferase (Group 1 HA039_RS28650 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HA039_RS28655 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HA039_RS28660 ENOG4105CDY transcriptional regulatory protein HA039_RS28665 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HA039_RS28670 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HA039_RS28675 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HA039_RS28685 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HA039_RS28690 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HA039_RS28695 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HA039_RS28700 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HA039_RS28705 ENOG4105C99 atpase involved in dna repair HA039_RS28720 ENOG4105CUT histidyl-tRNA synthetase HA039_RS28740 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HA039_RS28755 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HA039_RS28760 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HA039_RS28765 ENOG4105HHA aminodeoxychorismate lyase HA039_RS28770 ENOG4105E2X shikimate dehydrogenase HA039_RS28775 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HA039_RS28780 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HA039_RS28785 ENOG4105D49 3-dehydroquinate synthase HA039_RS28790 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HA039_RS28800 ENOG4105DC7 peptidase M24 HA039_RS28805 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HA039_RS28810 ENOG410803B Involved in the transcription termination process (By similarity) HA039_RS28820 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HA039_RS28825 ENOG4105CXT aspartate transcarbamylase HA039_RS28830 ENOG4105CD3 dihydroorotase HA039_RS28840 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HA039_RS28845 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HA039_RS28850 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HA039_RS28855 ENOG4105SKN orotidine 5''-phosphate decarboxylase HA039_RS28870 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HA039_RS28880 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HA039_RS28915 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HA039_RS28925 ENOG4105DJV ribulose-phosphate 3-epimerase HA039_RS28930 ENOG4105DKT Transcriptional regulator HA039_RS28940 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS28975 ENOG4105E2R ROK family HA039_RS28995 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HA039_RS29000 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HA039_RS29005 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HA039_RS29010 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HA039_RS29055 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS29065 ENOG4105EW9 transcriptional regulator AsnC family HA039_RS29075 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HA039_RS29085 ENOG4105Q70 HA039_RS29090 ENOG4105DEU major facilitator superfamily HA039_RS29145 ENOG4107R7A Allophanate hydrolase subunit 2 HA039_RS29150 ENOG4105P4J Allophanate hydrolase, subunit 1 HA039_RS29155 ENOG4105E7W lamb ycsf family protein HA039_RS29195 ENOG4105GWZ Roadblock lc7 family protein HA039_RS29210 ENOG4108UQS dipeptidase HA039_RS29225 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HA039_RS29235 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HA039_RS29240 ENOG4105C5Y PTS System HA039_RS29285 ENOG4108UW8 fha domain-containing protein HA039_RS29305 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HA039_RS29315 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HA039_RS29345 ENOG4105JAB phenazine biosynthesis protein, phzf family HA039_RS29385 ENOG4105CSW GntR family transcriptional regulator HA039_RS29390 ENOG4108Q5Y Membrane HA039_RS29410 ENOG4108IG5 Transcriptional regulator HA039_RS29440 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HA039_RS29445 ENOG4105FUA antagonist HA039_RS29450 ENOG4107MMM Anti-sigma-factor antagonist HA039_RS29465 ENOG4105E0A ABC, transporter HA039_RS29470 ENOG4105EHG Permease protein HA039_RS29490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HA039_RS29535 ENOG4105CHR reductase HA039_RS29545 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HA039_RS29565 ENOG4105EP9 oxidoreductase HA039_RS29570 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HA039_RS29580 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HA039_RS29605 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HA039_RS29635 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HA039_RS29670 ENOG4108Z0R Transferase HA039_RS29675 ENOG4106A3M Cytochrome p-450 HA039_RS29715 ENOG4105K4P CoA-binding domain protein HA039_RS29720 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HA039_RS29740 ENOG4105EYH Exonuclease HA039_RS29760 ENOG4108PSK reductase HA039_RS29775 ENOG41089UC methyltransferase, type 11 HA039_RS29780 ENOG41082YX Transcriptional regulator, arsr family HA039_RS29815 ENOG4106UW1 Major Facilitator superfamily HA039_RS29825 ENOG4108KPJ rna polymerase sigma factor HA039_RS29830 ENOG4105FDP GntR family transcriptional regulator HA039_RS29835 ENOG4105DKQ ROK family HA039_RS29840 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS29845 ENOG4105BZU Histidine kinase HA039_RS29865 ENOG4108VCA G U mismatch-specific DNA glycosylase HA039_RS29870 ENOG4105C83 adenylosuccinate lyase HA039_RS29890 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HA039_RS29895 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HA039_RS29900 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HA039_RS29935 ENOG4105C57 major facilitator superfamily HA039_RS29950 ENOG41064MX Tetr family transcriptional regulator HA039_RS29970 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HA039_RS29975 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HA039_RS29980 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HA039_RS29995 ENOG4107SN7 NLP P60 protein HA039_RS30015 ENOG4108YZ9 Urea amidohydrolase subunit gamma HA039_RS30020 ENOG4105KI2 Urea amidohydrolase subunit beta HA039_RS30035 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HA039_RS30070 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HA039_RS30075 ENOG4105C6F GntR Family Transcriptional Regulator HA039_RS30085 ENOG4105CXK mandelate racemase muconate lactonizing HA039_RS30095 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HA039_RS30100 ENOG4105DRS transport system, permease HA039_RS30105 ENOG4105F04 LysR family Transcriptional regulator HA039_RS30110 ENOG4105CHR reductase HA039_RS30125 ENOG4108ZX0 Signal peptidase I HA039_RS30135 ENOG4105EYF MMPL domain protein HA039_RS30140 ENOG4105BZU Histidine kinase HA039_RS30165 ENOG4105CAS nag kinase HA039_RS30170 ENOG4105E0A ABC, transporter HA039_RS30175 ENOG4108IHU transport system permease protein HA039_RS30180 ENOG4105DQ5 transport system permease protein HA039_RS30195 ENOG4108HUF Transporter HA039_RS30200 ENOG4105BZ1 (ABC) transporter HA039_RS30215 ENOG4105DZ6 Band 7 protein HA039_RS30220 ENOG4105NPE arsR family transcriptional regulator HA039_RS30240 ENOG4105CTQ phosphohexokinase HA039_RS30245 ENOG4105F1K Glutamine amidotransferase HA039_RS30255 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HA039_RS30265 ENOG4105C1G acyl-Coa dehydrogenase HA039_RS30280 ENOG4105C29 acyl-CoA thioesterase HA039_RS30305 ENOG4105BZ1 (ABC) transporter HA039_RS30310 ENOG4105BZ1 (ABC) transporter HA039_RS30330 ENOG4105H3G oxidoreductase HA039_RS30335 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HA039_RS30345 ENOG4105E2Y ABC, transporter HA039_RS30350 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HA039_RS30355 ENOG4107ZED Uncharacterised protein family UPF0047 HA039_RS30370 ENOG4105EMU Dehydrogenase HA039_RS30385 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HA039_RS30395 ENOG4105CPN adenine deaminase HA039_RS30400 ENOG4107R13 MMPL domain protein HA039_RS30405 ENOG4105EMU Dehydrogenase HA039_RS30435 ENOG4105DWV Homoserine O-trans-acetylase HA039_RS30440 ENOG4107T8T UPF0173 metal-dependent hydrolase HA039_RS30460 ENOG4105F0K SARP family transcriptional regulator HA039_RS30500 ENOG4105BZU Histidine kinase HA039_RS30505 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS30515 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HA039_RS30535 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HA039_RS30585 ENOG410829K Lysine exporter protein (Lyse ygga) HA039_RS30600 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HA039_RS30610 ENOG4108PSK reductase HA039_RS30655 ENOG4105WN5 stage II sporulation protein HA039_RS30665 ENOG4107RN3 metallophosphoesterase HA039_RS30685 ENOG4108IXY short-chain dehydrogenase reductase HA039_RS30700 ENOG4107S5I aldo keto reductase HA039_RS30710 ENOG4105CIS alcohol dehydrogenase HA039_RS30725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HA039_RS30730 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HA039_RS30735 ENOG4105C57 major facilitator superfamily HA039_RS30760 ENOG4105DND Transcriptional regulator HA039_RS30765 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS30785 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HA039_RS30790 ENOG4105DRS transport system, permease HA039_RS30795 ENOG4108RVA ribokinase HA039_RS30815 ENOG4105EMU Dehydrogenase HA039_RS30830 ENOG4107QN2 dihydrolipoyl dehydrogenase HA039_RS30835 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HA039_RS30870 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS30880 ENOG4105K4P CoA-binding domain protein HA039_RS30915 ENOG4107RTD sua5 ycio yrdc ywlc family protein HA039_RS30920 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS30925 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HA039_RS30945 ENOG4105EQ0 Major Facilitator superfamily HA039_RS30960 ENOG4105FBN Acid phosphatase HA039_RS30980 ENOG4105CIG ABC transporter HA039_RS31025 ENOG4107QN2 dihydrolipoyl dehydrogenase HA039_RS31095 ENOG4108HMN Caspase domain HA039_RS31110 ENOG4105CNF WD-40 repeat protein HA039_RS31175 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HA039_RS31185 ENOG4108IND Tetr family transcriptional regulator HA039_RS31190 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HA039_RS31200 ENOG4105CPC Aldo Keto reductase HA039_RS31205 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HA039_RS31210 ENOG4105E9K Isocitrate dehydrogenase HA039_RS31220 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HA039_RS31225 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HA039_RS31240 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HA039_RS31245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HA039_RS31250 ENOG4105YVS arsR family transcriptional regulator HA039_RS31280 ENOG410841Q phosphoesterase PA-phosphatase related protein HA039_RS31310 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HA039_RS31320 ENOG4105CXK mandelate racemase muconate lactonizing HA039_RS31325 ENOG4107HP6 Transcriptional regulator HA039_RS31335 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HA039_RS31340 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HA039_RS31345 ENOG4105CMR udp-glucose 4-epimerase HA039_RS31355 ENOG4107F2M hemolysin-type calcium-binding region HA039_RS31370 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HA039_RS31400 ENOG4105PSQ Acyl-transferase HA039_RS31425 ENOG4105C10 Electron transfer flavoprotein HA039_RS31435 ENOG4108DT4 serine threonine protein kinase HA039_RS31440 ENOG41060NJ transcriptional regulator HA039_RS31460 ENOG4105I1F Resistance protein HA039_RS31470 ENOG4107PP3 Acetylornithine deacetylase HA039_RS31475 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HA039_RS31495 ENOG4105BZU Histidine kinase HA039_RS31500 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS31515 ENOG4106UW1 Major Facilitator superfamily HA039_RS31520 ENOG4105E2R ROK family HA039_RS31560 ENOG4105MVE transcriptional regulator HA039_RS31570 ENOG4106F1P AAA ATPase, central domain protein HA039_RS31585 ENOG4105BZU Histidine kinase HA039_RS31595 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HA039_RS31620 ENOG4108JNI Alpha beta hydrolase HA039_RS31630 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HA039_RS31635 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HA039_RS31670 ENOG41080HT Transcriptional regulator, arsr family HA039_RS31695 ENOG4105CPT Alpha beta hydrolase HA039_RS31710 ENOG4107S5I aldo keto reductase HA039_RS31720 ENOG4105BZ9 Cytochrome C oxidase, subunit I HA039_RS31730 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HA039_RS31750 ENOG4108JQ1 Dehydrogenase HA039_RS31755 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HA039_RS31780 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HA039_RS31825 ENOG4108KGH TRANSCRIPTIONal HA039_RS31850 ENOG4105ETX regulatoR HA039_RS31870 ENOG4105D7N magnesium and cobalt transport protein CorA HA039_RS31930 ENOG4105EMU Dehydrogenase HA039_RS31945 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HA039_RS32005 ENOG4105C2J ABC transporter HA039_RS32010 ENOG4105CNN ABC, transporter HA039_RS32015 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS32025 ENOG4105CHP RNA polymerase HA039_RS32050 ENOG4105EGE secreted protein HA039_RS32090 ENOG4107S91 Sodium hydrogen exchanger HA039_RS32100 ENOG4105CGD Nad-dependent epimerase dehydratase HA039_RS32110 ENOG4108UTZ Dihydroxyacetone kinase HA039_RS32115 ENOG4105CMT Dihydroxyacetone kinase HA039_RS32150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HA039_RS32190 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HA039_RS32245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HA039_RS32250 ENOG4105EYF MMPL domain protein HA039_RS32255 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HA039_RS32260 ENOG4105F76 Sarcosine oxidase HA039_RS32300 ENOG4108HWW ABC transporter HA039_RS32305 ENOG4105C2J ABC transporter HA039_RS32310 ENOG4105DFW ABC transporter HA039_RS32325 ENOG4105C57 major facilitator superfamily HA039_RS32350 ENOG4108WYP Transcriptional regulator HA039_RS32365 ENOG4105CHM Aminotransferase HA039_RS32380 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HA039_RS32435 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HA039_RS32445 ENOG4107XGZ Hydrolase HA039_RS32470 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HA039_RS32475 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HA039_RS32515 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HA039_RS32525 ENOG4105CSR polyphosphate kinase 2 HA039_RS32560 ENOG4105CXK mandelate racemase muconate lactonizing HA039_RS32580 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HA039_RS32600 ENOG4105X1Q TOBE domain protein HA039_RS32630 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HA039_RS32645 ENOG4107S1E Beta-lactamase HA039_RS32660 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) HA039_RS32695 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HA039_RS32705 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HA039_RS32715 ENOG4108YIQ Alpha beta hydrolase HA039_RS32720 ENOG4105DND Transcriptional regulator HA039_RS32760 ENOG4108K8S endonuclease I HA039_RS32770 ENOG4106UDK Cellulose-binding, family II HA039_RS32775 ENOG4105EGE secreted protein HA039_RS32815 ENOG4105EC2 ftsk spoIIIe HA039_RS32860 ENOG4105D9P serine threonine protein kinase HA039_RS32885 ENOG4105QE3 oxidoreductase HA039_RS32910 ENOG4107R0W ABC transporter HA039_RS32915 ENOG4105EAD ABC transporter HA039_RS32970 ENOG4105BZP glycoside hydrolase 15-related HA039_RS32985 ENOG4105EXC Acyl-transferase HA039_RS32990 ENOG4105C3M thioredoxin reductase HA039_RS33015 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HA039_RS33020 ENOG4107VAM peptidase, m28 HA039_RS33065 ENOG4107SET aldo keto reductase HA039_RS33080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HA039_RS33105 ENOG4107T5V SNARE associated Golgi HA039_RS33130 ENOG4105CEP NADH dehydrogenase HA039_RS33135 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HA039_RS33145 ENOG4105XPP Protein of unknown function (DUF1275) HA039_RS33205 ENOG4105XYF acetyltransferase HA039_RS33235 ENOG4105ETE Transcriptional regulator (LacI family HA039_RS33245 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HA039_RS33250 ENOG4105EG2 ABC transporter, permease HA039_RS33265 ENOG4105CD3 dihydroorotase HA039_RS33305 ENOG4105CHU acetyl-coa acetyltransferase HA039_RS33310 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HA039_RS33315 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HA039_RS33320 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HA039_RS33325 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HA039_RS33330 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HA039_RS33345 ENOG4105C26 Dehydrogenase HA039_RS33355 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HA039_RS33360 ENOG41067SE Tetr family transcriptional regulator HA039_RS33365 ENOG4105EYF MMPL domain protein HA039_RS33370 ENOG4105CPC Aldo Keto reductase HA039_RS33395 ENOG4105CHR reductase HA039_RS33405 ENOG4105F27 Major Facilitator HA039_RS33430 ENOG4105WH1 Two component transcriptional regulator luxr family HA039_RS33435 ENOG4105BZU Histidine kinase HA039_RS33475 ENOG4108HMN Caspase domain