locus-tag	class	description
HA039_RS00045	COG0604	alcohol dehydrogenase
HA039_RS00045	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS00045	COG3321	synthase
HA039_RS00075	COG0667	Aldo Keto reductase
HA039_RS00095	COG2271	Major facilitator Superfamily
HA039_RS00100	COG1051	belongs to the nudix hydrolase family
HA039_RS00125	COG0395	ABC-type sugar transport system, permease component
HA039_RS00135	COG1653	transport
HA039_RS00150	COG0596	Alpha beta hydrolase
HA039_RS00155	COG2208	phosphoserine phosphatase activity
HA039_RS00155	COG2770	Histidine kinase
HA039_RS00165	COG1846	Transcriptional regulator
HA039_RS00170	COG1764	response to oxidative stress
HA039_RS00175	COG3467	pyridoxamine 5'-phosphate
HA039_RS00190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA039_RS00200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HA039_RS00210	COG0596	Alpha beta hydrolase
HA039_RS00250	COG0656	L-ascorbic acid biosynthetic process
HA039_RS00270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS00275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS00305	COG2837	iron assimilation
HA039_RS00350	COG0542	response to heat
HA039_RS00355	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HA039_RS00360	COG0596	Alpha beta hydrolase
HA039_RS00395	COG0308	aminopeptidase N
HA039_RS00400	COG0328	RNA-DNA hybrid ribonuclease activity
HA039_RS00420	COG1309	transcriptional regulator
HA039_RS00425	COG3540	Alkaline phosphatase
HA039_RS00455	COG2188	Transcriptional regulator
HA039_RS00500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HA039_RS00530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HA039_RS00560	COG3345	alpha-galactosidase
HA039_RS00565	COG0395	ABC-type sugar transport system, permease component
HA039_RS00570	COG1175	transmembrane transport
HA039_RS00580	COG1940	carbohydrate kinase activity
HA039_RS00580	COG1846	Transcriptional regulator
HA039_RS00590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HA039_RS00595	COG0543	2 iron, 2 sulfur cluster binding
HA039_RS00595	COG0633	Ferredoxin
HA039_RS00605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HA039_RS00625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HA039_RS00640	COG0513	Belongs to the DEAD box helicase family
HA039_RS00645	COG1278	Cold shock
HA039_RS00665	COG2226	methyltransferase
HA039_RS00670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HA039_RS00705	COG2340	Cysteine-rich secretory protein family
HA039_RS00720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA039_RS00720	COG1321	iron dependent repressor
HA039_RS00725	COG1121	(ABC) transporter
HA039_RS00730	COG0803	Belongs to the bacterial solute-binding protein 9 family
HA039_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS00750	COG3507	Belongs to the glycosyl hydrolase 43 family
HA039_RS00775	COG0656	L-ascorbic acid biosynthetic process
HA039_RS00795	COG0395	ABC-type sugar transport system, permease component
HA039_RS00800	COG1175	transmembrane transport
HA039_RS00815	COG0739	heme binding
HA039_RS00855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HA039_RS00885	COG0596	Alpha beta hydrolase
HA039_RS00895	COG1309	transcriptional regulator
HA039_RS00900	COG0076	glutamate decarboxylase activity
HA039_RS00915	COG3251	PFAM MbtH domain protein
HA039_RS00950	COG4608	Belongs to the ABC transporter superfamily
HA039_RS00955	COG0444	Belongs to the ABC transporter superfamily
HA039_RS00960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA039_RS00965	COG0601	transmembrane transport
HA039_RS00970	COG0747	negative chemotaxis
HA039_RS00980	COG1959	2 iron, 2 sulfur cluster binding
HA039_RS00990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HA039_RS01005	COG0825	malonyl-CoA metabolic process
HA039_RS01005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HA039_RS01010	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS01015	COG4335	DNA alkylation repair
HA039_RS01020	COG0656	L-ascorbic acid biosynthetic process
HA039_RS01025	COG2814	Major facilitator Superfamily
HA039_RS01030	COG0254	rRNA binding
HA039_RS01035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HA039_RS01040	COG0406	alpha-ribazole phosphatase activity
HA039_RS01055	COG1846	Transcriptional regulator
HA039_RS01065	COG1278	Cold shock
HA039_RS01070	COG0667	Aldo Keto reductase
HA039_RS01090	COG0523	cobalamin synthesis protein
HA039_RS01095	COG2890	protein-(glutamine-N5) methyltransferase activity
HA039_RS01100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA039_RS01105	COG1121	(ABC) transporter
HA039_RS01115	COG0803	Belongs to the bacterial solute-binding protein 9 family
HA039_RS01150	COG0135	phosphoribosylanthranilate isomerase activity
HA039_RS01155	COG1960	acyl-CoA dehydrogenase activity
HA039_RS01160	COG0662	Cupin 2, conserved barrel domain protein
HA039_RS01165	COG0159	tryptophan synthase activity
HA039_RS01180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA039_RS01185	COG2030	dehydratase
HA039_RS01190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS01195	COG0156	8-amino-7-oxononanoate synthase activity
HA039_RS01210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HA039_RS01225	COG2072	flavoprotein involved in K transport
HA039_RS01265	COG0702	epimerase
HA039_RS01305	COG2124	cytochrome p450
HA039_RS01310	COG3424	synthase
HA039_RS01320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HA039_RS01335	COG0583	DNA-binding transcription factor activity
HA039_RS01345	COG0456	acetyltransferase
HA039_RS01350	COG0667	Aldo Keto reductase
HA039_RS01355	COG0789	Transcriptional regulator
HA039_RS01365	COG2124	cytochrome p450
HA039_RS01375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HA039_RS01390	COG1132	(ABC) transporter
HA039_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS01405	COG1522	sequence-specific DNA binding
HA039_RS01420	COG2304	oxidoreductase activity
HA039_RS01430	COG1295	ribonuclease BN
HA039_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS01460	COG2018	Roadblock/LC7 domain
HA039_RS01495	COG3239	Fatty acid desaturase
HA039_RS01500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HA039_RS01515	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS01530	COG1960	acyl-CoA dehydrogenase activity
HA039_RS01535	COG1960	acyl-CoA dehydrogenase activity
HA039_RS01565	COG3458	cephalosporin-C deacetylase activity
HA039_RS01590	COG1053	succinate dehydrogenase
HA039_RS01600	COG0596	Alpha beta hydrolase
HA039_RS01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS01630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS01635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS01665	COG0515	serine threonine protein kinase
HA039_RS01665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HA039_RS01685	COG1595	DNA-templated transcription, initiation
HA039_RS01690	COG1309	transcriptional regulator
HA039_RS01715	COG3469	chitinase activity
HA039_RS01720	COG2188	Transcriptional regulator
HA039_RS01765	COG2746	aminoglycoside 3-N-acetyltransferase activity
HA039_RS01770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS01810	COG2084	Dehydrogenase
HA039_RS01840	COG3903	Transcriptional regulator
HA039_RS01840	COG3629	intracellular signal transduction
HA039_RS01855	COG1070	Carbohydrate kinase
HA039_RS01860	COG3347	Dehydrogenase
HA039_RS01860	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS01890	COG1335	isochorismatase
HA039_RS01895	COG2318	DinB family
HA039_RS01930	COG0477	Major facilitator Superfamily
HA039_RS01950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HA039_RS01965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HA039_RS01980	COG0784	Response regulator, receiver
HA039_RS02000	COG1609	Transcriptional regulator
HA039_RS02035	COG2197	response regulator
HA039_RS02105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HA039_RS02110	COG1301	dicarboxylic acid transport
HA039_RS02125	COG0300	oxidoreductase activity
HA039_RS02130	COG2814	Major facilitator Superfamily
HA039_RS02145	COG0583	DNA-binding transcription factor activity
HA039_RS02205	COG1960	acyl-CoA dehydrogenase activity
HA039_RS02225	COG0667	Aldo Keto reductase
HA039_RS02230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HA039_RS02235	COG0655	NAD(P)H dehydrogenase (quinone) activity
HA039_RS02240	COG1733	regulation of RNA biosynthetic process
HA039_RS02250	COG0583	DNA-binding transcription factor activity
HA039_RS02265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HA039_RS02270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS02340	COG1793	dna ligase
HA039_RS02340	COG3285	dna ligase
HA039_RS02345	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HA039_RS02380	COG0047	phosphoribosylformylglycinamidine synthase activity
HA039_RS02395	COG0477	Major facilitator Superfamily
HA039_RS02425	COG1126	abc transporter atp-binding protein
HA039_RS02445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HA039_RS02450	COG0531	amino acid
HA039_RS02490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HA039_RS02490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HA039_RS02505	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HA039_RS02550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA039_RS02555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA039_RS02585	COG3629	intracellular signal transduction
HA039_RS02585	COG3903	Transcriptional regulator
HA039_RS02595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HA039_RS02620	COG0017	Asparaginyl-tRNA synthetase
HA039_RS02625	COG0069	glutamate synthase activity
HA039_RS02635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA039_RS02645	COG3629	intracellular signal transduction
HA039_RS02645	COG3903	Transcriptional regulator
HA039_RS02655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HA039_RS02680	COG0440	acetolactate synthase activity
HA039_RS02685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HA039_RS02715	COG1309	transcriptional regulator
HA039_RS02735	COG3485	protocatechuate 3,4-dioxygenase
HA039_RS02745	COG1063	alcohol dehydrogenase
HA039_RS02765	COG1309	transcriptional regulator
HA039_RS02780	COG3903	Transcriptional regulator
HA039_RS02780	COG3629	intracellular signal transduction
HA039_RS02790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA039_RS02795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HA039_RS02805	COG1609	Transcriptional regulator
HA039_RS02825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HA039_RS02850	COG3572	ergothioneine biosynthetic process
HA039_RS02855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HA039_RS02860	COG0121	glutamine amidotransferase
HA039_RS02865	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HA039_RS02880	COG2182	Extracellular solute-binding protein
HA039_RS02885	COG4585	Histidine kinase
HA039_RS02895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA039_RS02905	COG2376	Dihydroxyacetone kinase
HA039_RS02910	COG3360	Dodecin
HA039_RS02920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS02935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HA039_RS02940	COG1053	succinate dehydrogenase
HA039_RS02990	COG0726	polysaccharide deacetylase
HA039_RS03015	COG3275	phosphorelay sensor kinase activity
HA039_RS03020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HA039_RS03040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HA039_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS03120	COG3321	synthase
HA039_RS03120	COG0604	alcohol dehydrogenase
HA039_RS03125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HA039_RS03130	COG0297	glycogen (starch) synthase activity
HA039_RS03165	COG1175	transmembrane transport
HA039_RS03170	COG0395	ABC-type sugar transport system, permease component
HA039_RS03185	COG1063	alcohol dehydrogenase
HA039_RS03205	COG1349	DNA-binding transcription factor activity
HA039_RS03210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HA039_RS03280	COG3540	Alkaline phosphatase
HA039_RS03290	COG0583	DNA-binding transcription factor activity
HA039_RS03295	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS03300	COG0028	Belongs to the TPP enzyme family
HA039_RS03305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HA039_RS03325	COG2971	BadF BadG BcrA BcrD
HA039_RS03335	COG0673	inositol 2-dehydrogenase activity
HA039_RS03350	COG2188	Transcriptional regulator
HA039_RS03355	COG0673	inositol 2-dehydrogenase activity
HA039_RS03380	COG4608	Belongs to the ABC transporter superfamily
HA039_RS03390	COG0601	transmembrane transport
HA039_RS03400	COG2188	Transcriptional regulator
HA039_RS03410	COG0628	permease
HA039_RS03435	COG2124	cytochrome p450
HA039_RS03450	COG3795	YCII-related domain
HA039_RS03455	COG4941	Belongs to the sigma-70 factor family
HA039_RS03470	COG1280	lysine exporter protein (LysE YggA)
HA039_RS03510	COG1295	ribonuclease BN
HA039_RS03540	COG4977	sequence-specific DNA binding
HA039_RS03555	COG2267	carboxylic ester hydrolase activity
HA039_RS03560	COG1960	acyl-CoA dehydrogenase activity
HA039_RS03565	COG0667	Aldo Keto reductase
HA039_RS03570	COG2770	Histidine kinase
HA039_RS03570	COG2208	phosphoserine phosphatase activity
HA039_RS03605	COG1215	transferase activity, transferring glycosyl groups
HA039_RS03610	COG1957	nucleoside hydrolase
HA039_RS03635	COG0583	DNA-binding transcription factor activity
HA039_RS03660	COG2207	Transcriptional regulator
HA039_RS03660	COG3708	Transcriptional regulator
HA039_RS03685	COG4106	trans-aconitate 2-methyltransferase activity
HA039_RS03700	COG1556	Lactate utilization protein
HA039_RS03705	COG1139	Iron-sulfur cluster binding protein
HA039_RS03710	COG0247	lactate metabolic process
HA039_RS03760	COG0784	Response regulator, receiver
HA039_RS03765	COG4251	negative regulation of phosphorylation
HA039_RS03780	COG2267	carboxylic ester hydrolase activity
HA039_RS03795	COG1968	undecaprenyl-diphosphatase activity
HA039_RS03800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA039_RS03815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HA039_RS03850	COG3629	intracellular signal transduction
HA039_RS03850	COG3903	Transcriptional regulator
HA039_RS03860	COG0513	Belongs to the DEAD box helicase family
HA039_RS03875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HA039_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS03970	COG4221	oxidoreductase activity
HA039_RS03995	COG2409	Drug exporters of the RND superfamily
HA039_RS04000	COG4585	Histidine kinase
HA039_RS04005	COG2197	response regulator
HA039_RS04010	COG1408	metallophosphoesterase
HA039_RS04015	COG1595	DNA-templated transcription, initiation
HA039_RS04030	COG2207	Transcriptional regulator
HA039_RS04035	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HA039_RS04085	COG3959	Transketolase, thiamine diphosphate binding domain
HA039_RS04090	COG3958	Transketolase
HA039_RS04105	COG0667	Aldo Keto reductase
HA039_RS04110	COG3507	Belongs to the glycosyl hydrolase 43 family
HA039_RS04115	COG1082	Xylose isomerase domain protein TIM barrel
HA039_RS04125	COG1396	sequence-specific DNA binding
HA039_RS04130	COG1116	anion transmembrane transporter activity
HA039_RS04140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HA039_RS04150	COG0604	alcohol dehydrogenase
HA039_RS04155	COG1476	TRANSCRIPTIONal
HA039_RS04190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HA039_RS04195	COG1349	DNA-binding transcription factor activity
HA039_RS04205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA039_RS04235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HA039_RS04245	COG2755	lipolytic protein G-D-S-L family
HA039_RS04255	COG2365	Tyrosine phosphatase family
HA039_RS04290	COG1657	PFAM Prenyltransferase squalene oxidase
HA039_RS04300	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HA039_RS04310	COG1562	ergosterol biosynthetic process
HA039_RS04315	COG1134	teichoic acid transport
HA039_RS04335	COG0371	Dehydrogenase
HA039_RS04360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HA039_RS04370	COG1024	Enoyl-CoA hydratase
HA039_RS04390	COG2183	response to ionizing radiation
HA039_RS04400	COG0789	Transcriptional regulator
HA039_RS04410	COG0488	(ABC) transporter
HA039_RS04425	COG2936	dipeptidyl-peptidase activity
HA039_RS04450	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA039_RS04450	COG1024	Enoyl-CoA hydratase
HA039_RS04455	COG0183	Belongs to the thiolase family
HA039_RS04460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HA039_RS04470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HA039_RS04490	COG1515	deoxyribonuclease V activity
HA039_RS04555	COG1793	dna ligase
HA039_RS04580	COG3012	SEC-C Motif Domain Protein
HA039_RS04600	COG1802	Transcriptional regulator
HA039_RS04605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HA039_RS04620	COG1414	Transcriptional regulator
HA039_RS04625	COG4948	Mandelate Racemase Muconate Lactonizing
HA039_RS04650	COG4214	carbohydrate transport
HA039_RS04655	COG1486	melibiose metabolic process
HA039_RS04695	COG0800	Aldolase
HA039_RS04705	COG4948	Mandelate Racemase Muconate Lactonizing
HA039_RS04710	COG2186	Transcriptional regulator
HA039_RS04725	COG0395	ABC-type sugar transport system, permease component
HA039_RS04730	COG1175	transmembrane transport
HA039_RS04740	COG3345	alpha-galactosidase
HA039_RS04745	COG1940	carbohydrate kinase activity
HA039_RS04770	COG0640	Transcriptional regulator
HA039_RS04775	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS04785	COG0156	8-amino-7-oxononanoate synthase activity
HA039_RS04790	COG1063	alcohol dehydrogenase
HA039_RS04845	COG1686	Belongs to the peptidase S11 family
HA039_RS04850	COG1357	PFAM Pentapeptide repeats (8 copies)
HA039_RS04895	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS04905	COG0045	succinate-CoA ligase (ADP-forming) activity
HA039_RS04915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HA039_RS04925	COG2223	nitrite transmembrane transporter activity
HA039_RS04960	COG1082	Xylose isomerase domain protein TIM barrel
HA039_RS04985	COG0673	inositol 2-dehydrogenase activity
HA039_RS04995	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA039_RS05000	COG1129	ABC transporter
HA039_RS05005	COG1940	carbohydrate kinase activity
HA039_RS05010	COG0667	Aldo Keto reductase
HA039_RS05015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HA039_RS05035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HA039_RS05050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HA039_RS05055	COG3383	formate dehydrogenase (NAD+) activity
HA039_RS05070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HA039_RS05085	COG0583	DNA-binding transcription factor activity
HA039_RS05095	COG0656	L-ascorbic acid biosynthetic process
HA039_RS05110	COG2154	pterin-4-alpha-carbinolamine dehydratase
HA039_RS05125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HA039_RS05150	COG1191	sigma factor activity
HA039_RS05175	COG0395	ABC-type sugar transport system, permease component
HA039_RS05180	COG1175	transmembrane transport
HA039_RS05185	COG1653	transport
HA039_RS05210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HA039_RS05215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HA039_RS05265	COG2226	methyltransferase
HA039_RS05275	COG0457	Tetratricopeptide repeat
HA039_RS05300	COG1619	proteins homologs of microcin C7 resistance protein MccF
HA039_RS05305	COG1506	peptidase
HA039_RS05305	COG0823	Involved in the tonB-independent uptake of proteins
HA039_RS05305	COG4946	Tricorn protease homolog
HA039_RS05310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA039_RS05315	COG2362	D-Aminopeptidase
HA039_RS05330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA039_RS05340	COG1461	Dihydroxyacetone kinase
HA039_RS05345	COG2376	Dihydroxyacetone kinase
HA039_RS05385	COG4585	Histidine kinase
HA039_RS05390	COG2197	response regulator
HA039_RS05415	COG0604	alcohol dehydrogenase
HA039_RS05420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HA039_RS05420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HA039_RS05425	COG2301	Belongs to the HpcH HpaI aldolase family
HA039_RS05435	COG1960	acyl-CoA dehydrogenase activity
HA039_RS05440	COG0688	phosphatidylethanolamine metabolic process
HA039_RS05465	COG0559	Belongs to the binding-protein-dependent transport system permease family
HA039_RS05500	COG1929	Belongs to the glycerate kinase type-1 family
HA039_RS05510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HA039_RS05520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HA039_RS05530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HA039_RS05545	COG0483	inositol monophosphate 1-phosphatase activity
HA039_RS05560	COG0431	NADPH-dependent FMN reductase
HA039_RS05570	COG2267	carboxylic ester hydrolase activity
HA039_RS05580	COG1953	Uracil, thiamine, allantoin
HA039_RS05585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS05590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HA039_RS05595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HA039_RS05615	COG0405	Gamma-glutamyltransferase
HA039_RS05620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HA039_RS05650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HA039_RS05715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS05720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS05725	COG1960	acyl-CoA dehydrogenase activity
HA039_RS05745	COG0604	alcohol dehydrogenase
HA039_RS05745	COG3321	synthase
HA039_RS05755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HA039_RS05760	COG0596	Alpha beta hydrolase
HA039_RS05790	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HA039_RS05810	COG0765	amino acid transport
HA039_RS05815	COG0765	amino acid transport
HA039_RS05820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA039_RS05835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HA039_RS05840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HA039_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS05875	COG2197	response regulator
HA039_RS05885	COG0300	oxidoreductase activity
HA039_RS05910	COG0789	Transcriptional regulator
HA039_RS05915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HA039_RS05920	COG0477	Major facilitator Superfamily
HA039_RS05960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA039_RS06000	COG0477	Major facilitator Superfamily
HA039_RS06025	COG1309	transcriptional regulator
HA039_RS06035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HA039_RS06055	COG0395	ABC-type sugar transport system, permease component
HA039_RS06060	COG4209	transmembrane transport
HA039_RS06065	COG1940	carbohydrate kinase activity
HA039_RS06120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS06130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HA039_RS06140	COG0477	Major facilitator Superfamily
HA039_RS06150	COG2226	methyltransferase
HA039_RS06165	COG0477	Major facilitator Superfamily
HA039_RS06175	COG1940	carbohydrate kinase activity
HA039_RS06180	COG1129	ABC transporter
HA039_RS06195	COG2188	Transcriptional regulator
HA039_RS06200	COG0673	inositol 2-dehydrogenase activity
HA039_RS06210	COG2197	response regulator
HA039_RS06220	COG4266	Belongs to the allantoicase family
HA039_RS06225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HA039_RS06230	COG1414	Transcriptional regulator
HA039_RS06255	COG1733	regulation of RNA biosynthetic process
HA039_RS06275	COG3537	Alpha-1,2-mannosidase
HA039_RS06280	COG1595	DNA-templated transcription, initiation
HA039_RS06295	COG2351	hydroxyisourate hydrolase activity
HA039_RS06325	COG3622	Belongs to the hyi family
HA039_RS06330	COG2084	Dehydrogenase
HA039_RS06335	COG3960	tartronate-semialdehyde synthase activity
HA039_RS06345	COG0702	epimerase
HA039_RS06355	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS06360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HA039_RS06365	COG2197	response regulator
HA039_RS06390	COG2706	6-phosphogluconolactonase activity
HA039_RS06395	COG5297	Belongs to the glycosyl hydrolase family 6
HA039_RS06395	COG2273	Hydrolase Family 16
HA039_RS06400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HA039_RS06405	COG2252	PERMEase
HA039_RS06410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HA039_RS06435	COG1132	(ABC) transporter
HA039_RS06440	COG1132	(ABC) transporter
HA039_RS06470	COG2124	cytochrome p450
HA039_RS06480	COG1802	Transcriptional regulator
HA039_RS06500	COG0028	Belongs to the TPP enzyme family
HA039_RS06525	COG1162	GTPase activity
HA039_RS06535	COG3511	phospholipase C
HA039_RS06540	COG0366	Alpha amylase catalytic
HA039_RS06555	COG0655	NAD(P)H dehydrogenase (quinone) activity
HA039_RS06565	COG5002	protein histidine kinase activity
HA039_RS06570	COG0745	RESPONSE REGULATOR receiver
HA039_RS06590	COG1960	acyl-CoA dehydrogenase activity
HA039_RS06615	COG0175	sulfate reduction
HA039_RS06620	COG0529	Catalyzes the synthesis of activated sulfate
HA039_RS06640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HA039_RS06645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HA039_RS06655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HA039_RS06660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HA039_RS06690	COG1175	transmembrane transport
HA039_RS06740	COG2124	cytochrome p450
HA039_RS06745	COG1716	ATPase activity
HA039_RS06765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HA039_RS06780	COG0346	lactoylglutathione lyase activity
HA039_RS06795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HA039_RS06800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HA039_RS06855	COG3220	belongs to the UPF0276 family
HA039_RS06940	COG1674	ftsk spoiiie
HA039_RS06945	COG1404	Belongs to the peptidase S8 family
HA039_RS06975	COG0446	pyridine nucleotide-disulphide oxidoreductase
HA039_RS06980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HA039_RS07000	COG0183	Belongs to the thiolase family
HA039_RS07005	COG1024	Enoyl-CoA hydratase
HA039_RS07005	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA039_RS07025	COG0531	amino acid
HA039_RS07030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HA039_RS07035	COG4214	carbohydrate transport
HA039_RS07045	COG4213	ABC transporter substrate-binding protein
HA039_RS07050	COG1940	carbohydrate kinase activity
HA039_RS07055	COG0395	ABC-type sugar transport system, permease component
HA039_RS07060	COG1175	transmembrane transport
HA039_RS07065	COG1653	transport
HA039_RS07080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HA039_RS07105	COG0574	Belongs to the PEP-utilizing enzyme family
HA039_RS07105	COG3848	Pyruvate phosphate dikinase
HA039_RS07115	COG1070	Carbohydrate kinase
HA039_RS07120	COG1349	DNA-binding transcription factor activity
HA039_RS07145	COG0395	ABC-type sugar transport system, permease component
HA039_RS07160	COG3250	beta-galactosidase activity
HA039_RS07170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HA039_RS07195	COG1111	helicase
HA039_RS07195	COG1205	dead DEAH box helicase
HA039_RS07205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HA039_RS07305	COG0501	Belongs to the peptidase M48B family
HA039_RS07325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HA039_RS07330	COG2235	arginine
HA039_RS07335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HA039_RS07345	COG2040	homocysteine
HA039_RS07370	COG1799	cell septum assembly
HA039_RS07390	COG1175	transmembrane transport
HA039_RS07395	COG0395	ABC-type sugar transport system, permease component
HA039_RS07405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HA039_RS07480	COG1472	Belongs to the glycosyl hydrolase 3 family
HA039_RS07490	COG1309	transcriptional regulator
HA039_RS07540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HA039_RS07585	COG0024	Methionine aminopeptidase
HA039_RS07595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HA039_RS07605	COG0596	Alpha beta hydrolase
HA039_RS07610	COG1309	transcriptional regulator
HA039_RS07625	COG0300	oxidoreductase activity
HA039_RS07655	COG0583	DNA-binding transcription factor activity
HA039_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS07675	COG0110	maltose O-acetyltransferase activity
HA039_RS07695	COG1819	glycosyl
HA039_RS07725	COG0693	protein deglycase activity
HA039_RS07735	COG4989	oxidoreductase activity
HA039_RS07745	COG1175	transmembrane transport
HA039_RS07750	COG0395	ABC-type sugar transport system, permease component
HA039_RS07755	COG1653	transport
HA039_RS07765	COG5434	Belongs to the glycosyl hydrolase 28 family
HA039_RS07785	COG0667	Aldo Keto reductase
HA039_RS07795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA039_RS07800	COG1131	(ABC) transporter
HA039_RS07820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HA039_RS07825	COG0531	amino acid
HA039_RS07830	COG0569	domain protein
HA039_RS07860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HA039_RS07865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HA039_RS07870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HA039_RS07885	COG0756	dUTP diphosphatase activity
HA039_RS07905	COG2205	protein histidine kinase activity
HA039_RS07910	COG0745	RESPONSE REGULATOR receiver
HA039_RS07955	COG1435	thymidine kinase activity
HA039_RS07975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA039_RS07980	COG1802	Transcriptional regulator
HA039_RS07990	COG0612	Peptidase, M16
HA039_RS07995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HA039_RS08015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA039_RS08035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA039_RS08045	COG0366	Alpha amylase catalytic
HA039_RS08050	COG0395	ABC-type sugar transport system, permease component
HA039_RS08055	COG1175	transmembrane transport
HA039_RS08065	COG1131	(ABC) transporter
HA039_RS08090	COG3290	protein histidine kinase activity
HA039_RS08095	COG4565	transcriptional regulatory protein
HA039_RS08100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HA039_RS08110	COG2197	response regulator
HA039_RS08115	COG4585	Histidine kinase
HA039_RS08125	COG0187	DNA topoisomerase II activity
HA039_RS08140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HA039_RS08145	COG1802	Transcriptional regulator
HA039_RS08170	COG0514	ATP-dependent DNA helicase (RecQ)
HA039_RS08185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HA039_RS08210	COG0588	phosphoglycerate mutase activity
HA039_RS08235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HA039_RS08275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HA039_RS08285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HA039_RS08290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HA039_RS08300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HA039_RS08305	COG2267	carboxylic ester hydrolase activity
HA039_RS08310	COG2378	regulation of single-species biofilm formation
HA039_RS08325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HA039_RS08335	COG2205	protein histidine kinase activity
HA039_RS08340	COG0745	RESPONSE REGULATOR receiver
HA039_RS08345	COG1126	abc transporter atp-binding protein
HA039_RS08350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA039_RS08355	COG0765	amino acid transport
HA039_RS08360	COG0765	amino acid transport
HA039_RS08395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HA039_RS08420	COG2365	Tyrosine phosphatase family
HA039_RS08425	COG2814	Major facilitator Superfamily
HA039_RS08430	COG1742	UPF0060 membrane protein
HA039_RS08460	COG1201	RNA secondary structure unwinding
HA039_RS08470	COG0783	Belongs to the Dps family
HA039_RS08475	COG1396	sequence-specific DNA binding
HA039_RS08480	COG1058	Belongs to the CinA family
HA039_RS08480	COG1546	Belongs to the CinA family
HA039_RS08490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HA039_RS08500	COG1674	ftsk spoiiie
HA039_RS08510	COG2205	protein histidine kinase activity
HA039_RS08510	COG3437	response regulator, receiver
HA039_RS08510	COG4999	Histidine kinase
HA039_RS08510	COG3850	Histidine kinase
HA039_RS08515	COG2770	Histidine kinase
HA039_RS08515	COG2208	phosphoserine phosphatase activity
HA039_RS08545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HA039_RS08550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HA039_RS08555	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HA039_RS08575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HA039_RS08580	COG0612	Peptidase, M16
HA039_RS08585	COG1185	polyribonucleotide nucleotidyltransferase activity
HA039_RS08590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HA039_RS08600	COG1674	ftsk spoiiie
HA039_RS08635	COG1404	Belongs to the peptidase S8 family
HA039_RS08650	COG1404	Belongs to the peptidase S8 family
HA039_RS08675	COG0455	bacterial-type flagellum organization
HA039_RS08680	COG0747	negative chemotaxis
HA039_RS08685	COG0601	transmembrane transport
HA039_RS08690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA039_RS08700	COG4608	Belongs to the ABC transporter superfamily
HA039_RS08710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HA039_RS08715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HA039_RS08725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HA039_RS08740	COG0779	Required for maturation of 30S ribosomal subunits
HA039_RS08760	COG0442	prolyl-tRNA aminoacylation
HA039_RS08775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HA039_RS08780	COG0750	zinc metalloprotease
HA039_RS08785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HA039_RS08810	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS08815	COG2508	Transcriptional regulator
HA039_RS08815	COG2508	Transcriptional regulator
HA039_RS08845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA039_RS08850	COG1177	transmembrane transport
HA039_RS08855	COG1176	ABC-type spermidine putrescine transport system, permease component I
HA039_RS08860	COG3842	ATPase activity
HA039_RS08865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HA039_RS08885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HA039_RS08900	COG4585	Histidine kinase
HA039_RS08905	COG2197	response regulator
HA039_RS08915	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS08925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HA039_RS08930	COG1136	(ABC) transporter
HA039_RS08940	COG2382	esterase
HA039_RS08945	COG3842	ATPase activity
HA039_RS08950	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HA039_RS08960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HA039_RS08965	COG0575	Belongs to the CDS family
HA039_RS08970	COG0233	cytoplasmic translational termination
HA039_RS08975	COG0528	UMP kinase activity
HA039_RS08980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HA039_RS08985	COG0052	Belongs to the universal ribosomal protein uS2 family
HA039_RS08990	COG1388	LysM domain
HA039_RS08990	COG4942	peptidase
HA039_RS09000	COG1191	sigma factor activity
HA039_RS09015	COG0792	nuclease activity
HA039_RS09025	COG0494	nUDIX hydrolase
HA039_RS09030	COG0681	Belongs to the peptidase S26 family
HA039_RS09035	COG0681	Belongs to the peptidase S26 family
HA039_RS09050	COG0335	large ribosomal subunit rRNA binding
HA039_RS09055	COG0336	Belongs to the RNA methyltransferase TrmD family
HA039_RS09060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HA039_RS09065	COG1837	Belongs to the UPF0109 family
HA039_RS09070	COG0228	four-way junction DNA binding
HA039_RS09080	COG4106	trans-aconitate 2-methyltransferase activity
HA039_RS09090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HA039_RS09125	COG0477	Major facilitator Superfamily
HA039_RS09140	COG1254	Belongs to the acylphosphatase family
HA039_RS09145	COG2340	Cysteine-rich secretory protein family
HA039_RS09150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HA039_RS09155	COG0571	ribonuclease III activity
HA039_RS09160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HA039_RS09175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HA039_RS09180	COG0742	ribosomal rna small subunit methyltransferase
HA039_RS09185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HA039_RS09190	COG1461	Dihydroxyacetone kinase
HA039_RS09195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HA039_RS09200	COG0351	phosphomethylpyrimidine kinase
HA039_RS09220	COG1181	Belongs to the D-alanine--D-alanine ligase family
HA039_RS09225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HA039_RS09235	COG1920	GTP binding
HA039_RS09240	COG0776	regulation of translation
HA039_RS09250	COG0066	3-isopropylmalate dehydratase activity
HA039_RS09255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HA039_RS09260	COG1414	Transcriptional regulator
HA039_RS09290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HA039_RS09295	COG0179	Fumarylacetoacetate (FAA) hydrolase
HA039_RS09305	COG5002	protein histidine kinase activity
HA039_RS09310	COG2018	Roadblock/LC7 domain
HA039_RS09330	COG2018	Roadblock/LC7 domain
HA039_RS09350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HA039_RS09355	COG5492	domain, Protein
HA039_RS09375	COG1472	Belongs to the glycosyl hydrolase 3 family
HA039_RS09390	COG1609	Transcriptional regulator
HA039_RS09400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HA039_RS09405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HA039_RS09410	COG0473	3-isopropylmalate dehydrogenase activity
HA039_RS09420	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS09425	COG0506	proline dehydrogenase activity
HA039_RS09440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HA039_RS09445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HA039_RS09450	COG0440	acetolactate synthase activity
HA039_RS09470	COG0667	Aldo Keto reductase
HA039_RS09475	COG2133	pyrroloquinoline quinone binding
HA039_RS09490	COG1672	PFAM Archaeal ATPase
HA039_RS09490	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HA039_RS09510	COG2409	Drug exporters of the RND superfamily
HA039_RS09515	COG1309	transcriptional regulator
HA039_RS09525	COG3979	chitinase
HA039_RS09530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HA039_RS09535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HA039_RS09545	COG0154	amidase activity
HA039_RS09550	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HA039_RS09560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HA039_RS09595	COG0482	sulfurtransferase activity
HA039_RS09615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HA039_RS09625	COG2860	membrane
HA039_RS09630	COG4608	Belongs to the ABC transporter superfamily
HA039_RS09635	COG0444	Belongs to the ABC transporter superfamily
HA039_RS09645	COG4166	transmembrane transport
HA039_RS09670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HA039_RS09675	COG0509	glycine decarboxylation via glycine cleavage system
HA039_RS09680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HA039_RS09685	COG1760	l-serine dehydratase
HA039_RS09695	COG2124	cytochrome p450
HA039_RS09710	COG2197	response regulator
HA039_RS09725	COG1473	amidohydrolase
HA039_RS09740	COG0477	Major facilitator Superfamily
HA039_RS09765	COG1960	acyl-CoA dehydrogenase activity
HA039_RS09795	COG1376	ErfK ybiS ycfS ynhG family protein
HA039_RS09830	COG1376	ErfK ybiS ycfS ynhG family protein
HA039_RS09840	COG2197	response regulator
HA039_RS09845	COG4585	Histidine kinase
HA039_RS09855	COG1131	(ABC) transporter
HA039_RS09860	COG1132	(ABC) transporter
HA039_RS09865	COG1132	(ABC) transporter
HA039_RS09910	COG0058	SHG alpha-glucan phosphorylase activity
HA039_RS09915	COG0366	Alpha amylase catalytic
HA039_RS09920	COG0366	Alpha amylase catalytic
HA039_RS09930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HA039_RS09945	COG3118	belongs to the thioredoxin family
HA039_RS09950	COG0789	Transcriptional regulator
HA039_RS09960	COG0667	Aldo Keto reductase
HA039_RS09965	COG4106	trans-aconitate 2-methyltransferase activity
HA039_RS10010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HA039_RS10025	COG1301	dicarboxylic acid transport
HA039_RS10030	COG3290	protein histidine kinase activity
HA039_RS10035	COG4565	transcriptional regulatory protein
HA039_RS10040	COG1674	ftsk spoiiie
HA039_RS10050	COG0205	6-phosphofructokinase activity
HA039_RS10055	COG0280	phosphate acetyltransferase
HA039_RS10055	COG0857	belongs to the CobB CobQ family
HA039_RS10060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HA039_RS10110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HA039_RS10110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HA039_RS10150	COG0577	efflux transmembrane transporter activity
HA039_RS10150	COG1136	(ABC) transporter
HA039_RS10155	COG1136	(ABC) transporter
HA039_RS10250	COG2205	protein histidine kinase activity
HA039_RS10255	COG0745	RESPONSE REGULATOR receiver
HA039_RS10275	COG0183	Belongs to the thiolase family
HA039_RS10330	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HA039_RS10355	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA039_RS10370	COG4585	Histidine kinase
HA039_RS10375	COG2197	response regulator
HA039_RS10390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HA039_RS10395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HA039_RS10400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HA039_RS10405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HA039_RS10410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HA039_RS10415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HA039_RS10420	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HA039_RS10440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HA039_RS10445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HA039_RS10455	COG2890	protein-(glutamine-N5) methyltransferase activity
HA039_RS10460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HA039_RS10465	COG0254	rRNA binding
HA039_RS10480	COG0083	homoserine kinase activity
HA039_RS10485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HA039_RS10490	COG0460	homoserine dehydrogenase
HA039_RS10495	COG0019	diaminopimelate decarboxylase activity
HA039_RS10500	COG0018	arginyl-trna synthetase
HA039_RS10505	COG0745	RESPONSE REGULATOR receiver
HA039_RS10520	COG2197	response regulator
HA039_RS10525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HA039_RS10530	COG1793	dna ligase
HA039_RS10530	COG3285	dna ligase
HA039_RS10555	COG1733	regulation of RNA biosynthetic process
HA039_RS10560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HA039_RS10590	COG0791	NLP P60 protein
HA039_RS10590	COG3883	PFAM NLP P60 protein
HA039_RS10650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HA039_RS10665	COG0745	RESPONSE REGULATOR receiver
HA039_RS10670	COG2205	protein histidine kinase activity
HA039_RS10675	COG0508	dehydrogenase complex catalyzes the overall conversion of
HA039_RS10675	COG0567	Dehydrogenase, E1 component
HA039_RS10695	COG0604	alcohol dehydrogenase
HA039_RS10700	COG0281	malic enzyme
HA039_RS10715	COG1126	abc transporter atp-binding protein
HA039_RS10780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HA039_RS10790	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HA039_RS10820	COG1597	lipid kinase activity
HA039_RS10835	COG0363	glucosamine-6-phosphate deaminase activity
HA039_RS10840	COG1472	Belongs to the glycosyl hydrolase 3 family
HA039_RS10845	COG0395	ABC-type sugar transport system, permease component
HA039_RS10850	COG1175	transmembrane transport
HA039_RS10855	COG2182	Extracellular solute-binding protein
HA039_RS10860	COG2188	Transcriptional regulator
HA039_RS10880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HA039_RS10900	COG0242	peptide deformylase activity
HA039_RS10915	COG2199	diguanylate cyclase activity
HA039_RS10915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HA039_RS10920	COG5662	AntiSigma factor
HA039_RS10925	COG1595	DNA-templated transcription, initiation
HA039_RS10935	COG2135	peptidase activity
HA039_RS10945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HA039_RS10950	COG1162	GTPase activity
HA039_RS10955	COG2076	Multidrug Resistance protein
HA039_RS10965	COG0483	inositol monophosphate 1-phosphatase activity
HA039_RS10975	COG0753	catalase activity
HA039_RS11000	COG1615	UPF0182 protein
HA039_RS11010	COG3480	Lon protease (S16) C-terminal proteolytic domain
HA039_RS11060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HA039_RS11095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA039_RS11170	COG0601	transmembrane transport
HA039_RS11175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA039_RS11190	COG0596	Alpha beta hydrolase
HA039_RS11230	COG1432	Conserved Protein
HA039_RS11240	COG2095	MarC family integral membrane protein
HA039_RS11260	COG0598	Magnesium transport protein CorA
HA039_RS11295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HA039_RS11300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HA039_RS11310	COG1595	DNA-templated transcription, initiation
HA039_RS11325	COG1024	Enoyl-CoA hydratase
HA039_RS11330	COG0519	Catalyzes the synthesis of GMP from XMP
HA039_RS11340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HA039_RS11345	COG1611	Belongs to the LOG family
HA039_RS11350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA039_RS11405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HA039_RS11420	COG1131	(ABC) transporter
HA039_RS11430	COG4585	Histidine kinase
HA039_RS11435	COG2197	response regulator
HA039_RS11440	COG4608	Belongs to the ABC transporter superfamily
HA039_RS11450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA039_RS11455	COG0601	transmembrane transport
HA039_RS11460	COG4166	transmembrane transport
HA039_RS11470	COG4166	transmembrane transport
HA039_RS11475	COG0601	transmembrane transport
HA039_RS11480	COG0444	Belongs to the ABC transporter superfamily
HA039_RS11485	COG4608	Belongs to the ABC transporter superfamily
HA039_RS11490	COG4608	Belongs to the ABC transporter superfamily
HA039_RS11495	COG0444	Belongs to the ABC transporter superfamily
HA039_RS11500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA039_RS11530	COG1335	isochorismatase
HA039_RS11610	COG0012	GTP binding
HA039_RS11625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HA039_RS11630	COG0531	amino acid
HA039_RS11635	COG1570	exodeoxyribonuclease VII activity
HA039_RS11640	COG1722	exodeoxyribonuclease VII activity
HA039_RS11665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HA039_RS11665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HA039_RS11670	COG0114	fumarate hydratase activity
HA039_RS11690	COG4499	WXG100 protein secretion system (Wss), protein YukC
HA039_RS11690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HA039_RS11695	COG0450	alkyl hydroperoxide reductase
HA039_RS11700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA039_RS11720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HA039_RS11725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HA039_RS11730	COG0667	Aldo Keto reductase
HA039_RS11755	COG2885	chlorophyll binding
HA039_RS11770	COG2197	response regulator
HA039_RS11805	COG2894	cell division
HA039_RS11830	COG2610	gluconate transmembrane transporter activity
HA039_RS11835	COG0251	oxidation-reduction process
HA039_RS11840	COG1414	Transcriptional regulator
HA039_RS11855	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HA039_RS11935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA039_RS11945	COG1802	Transcriptional regulator
HA039_RS11955	COG2409	Drug exporters of the RND superfamily
HA039_RS11970	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HA039_RS11980	COG1309	transcriptional regulator
HA039_RS11985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HA039_RS11985	COG2010	Cytochrome c
HA039_RS11990	COG2080	2 iron, 2 sulfur cluster binding
HA039_RS12000	COG0367	asparagine synthase
HA039_RS12030	COG0463	Glycosyl transferase, family 2
HA039_RS12045	COG1331	Highly conserved protein containing a thioredoxin domain
HA039_RS12090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HA039_RS12100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HA039_RS12115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HA039_RS12120	COG2255	four-way junction helicase activity
HA039_RS12145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HA039_RS12165	COG0488	(ABC) transporter
HA039_RS12180	COG1136	(ABC) transporter
HA039_RS12190	COG1376	ErfK ybiS ycfS ynhG family protein
HA039_RS12205	COG2986	histidine ammonia-lyase
HA039_RS12215	COG1024	Enoyl-CoA hydratase
HA039_RS12225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HA039_RS12235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HA039_RS12245	COG0424	maF-like protein
HA039_RS12255	COG4770	biotin carboxylase activity
HA039_RS12260	COG1349	DNA-binding transcription factor activity
HA039_RS12280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HA039_RS12305	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS12310	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS12330	COG1595	DNA-templated transcription, initiation
HA039_RS12335	COG0745	RESPONSE REGULATOR receiver
HA039_RS12340	COG2205	protein histidine kinase activity
HA039_RS12365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HA039_RS12375	COG0583	DNA-binding transcription factor activity
HA039_RS12380	COG2814	Major facilitator Superfamily
HA039_RS12430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HA039_RS12430	COG1473	amidohydrolase
HA039_RS12440	COG2089	acid synthase
HA039_RS12455	COG1216	Glycosyl transferase, family 2
HA039_RS12480	COG1595	DNA-templated transcription, initiation
HA039_RS12510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HA039_RS12515	COG2814	Major facilitator Superfamily
HA039_RS12515	COG0477	Major facilitator Superfamily
HA039_RS12520	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HA039_RS12540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HA039_RS12555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HA039_RS12565	COG2009	succinate dehydrogenase
HA039_RS12575	COG1053	succinate dehydrogenase
HA039_RS12610	COG1309	transcriptional regulator
HA039_RS12620	COG1408	metallophosphoesterase
HA039_RS12645	COG0671	phosphoesterase, PA-phosphatase related
HA039_RS12670	COG0180	Tryptophanyl-tRNA synthetase
HA039_RS12680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HA039_RS12685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HA039_RS12690	COG0754	glutathionylspermidine amidase activity
HA039_RS12705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA039_RS12710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA039_RS12730	COG2814	Major facilitator Superfamily
HA039_RS12735	COG2304	oxidoreductase activity
HA039_RS12740	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS12745	COG0039	L-malate dehydrogenase activity
HA039_RS12755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HA039_RS12760	COG1714	RDD family
HA039_RS12765	COG0138	bifunctional purine biosynthesis protein purh
HA039_RS12795	COG0045	succinate-CoA ligase (ADP-forming) activity
HA039_RS12800	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HA039_RS12805	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HA039_RS12810	COG0714	Associated with various cellular activities
HA039_RS12830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HA039_RS12840	COG0739	heme binding
HA039_RS12875	COG2197	response regulator
HA039_RS12915	COG0519	Catalyzes the synthesis of GMP from XMP
HA039_RS12915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HA039_RS12935	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS12945	COG0515	serine threonine protein kinase
HA039_RS12960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HA039_RS12975	COG0516	GMP reductase activity
HA039_RS12985	COG1595	DNA-templated transcription, initiation
HA039_RS13000	COG0583	DNA-binding transcription factor activity
HA039_RS13010	COG2132	Multicopper oxidase
HA039_RS13015	COG4221	oxidoreductase activity
HA039_RS13045	COG0459	protein refolding
HA039_RS13055	COG0726	polysaccharide deacetylase
HA039_RS13070	COG2318	DinB family
HA039_RS13085	COG0477	Major facilitator Superfamily
HA039_RS13105	COG3409	Peptidoglycan-binding domain 1 protein
HA039_RS13110	COG4941	Belongs to the sigma-70 factor family
HA039_RS13120	COG1234	tRNA 3'-trailer cleavage
HA039_RS13155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HA039_RS13185	COG0802	atpase or kinase
HA039_RS13195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HA039_RS13205	COG0736	holo-[acyl-carrier-protein] synthase activity
HA039_RS13210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HA039_RS13230	COG1072	(Pantothenic acid kinase))
HA039_RS13235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HA039_RS13240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HA039_RS13245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HA039_RS13250	COG0488	(ABC) transporter
HA039_RS13270	COG0101	tRNA pseudouridine synthase activity
HA039_RS13275	COG0203	ribosomal protein L17
HA039_RS13280	COG0202	RNA polymerase activity
HA039_RS13285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HA039_RS13290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HA039_RS13295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HA039_RS13300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HA039_RS13310	COG0563	adenylate kinase activity
HA039_RS13320	COG0200	Binds to the 23S rRNA
HA039_RS13325	COG1841	ribosomal large subunit assembly
HA039_RS13330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HA039_RS13335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HA039_RS13340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HA039_RS13345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HA039_RS13355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HA039_RS13360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HA039_RS13365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HA039_RS13370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HA039_RS13375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HA039_RS13380	COG0255	Belongs to the universal ribosomal protein uL29 family
HA039_RS13385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HA039_RS13390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HA039_RS13395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HA039_RS13400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HA039_RS13405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HA039_RS13410	COG0089	rRNA binding
HA039_RS13415	COG0088	Forms part of the polypeptide exit tunnel
HA039_RS13420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HA039_RS13425	COG0051	transcription antitermination factor activity, RNA binding
HA039_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS13485	COG2409	Drug exporters of the RND superfamily
HA039_RS13500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HA039_RS13505	COG0049	tRNA binding
HA039_RS13510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HA039_RS13515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HA039_RS13520	COG0085	RNA polymerase activity
HA039_RS13525	COG0222	ribosome binding
HA039_RS13530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HA039_RS13535	COG0081	regulation of translation
HA039_RS13540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HA039_RS13550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HA039_RS13560	COG0436	Aminotransferase
HA039_RS13565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HA039_RS13570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HA039_RS13575	COG0477	Major facilitator Superfamily
HA039_RS13590	COG2030	dehydratase
HA039_RS13595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HA039_RS13610	COG0402	S-adenosylhomocysteine deaminase activity
HA039_RS13615	COG0702	epimerase
HA039_RS13630	COG1666	GTP binding
HA039_RS13650	COG3304	Inner membrane component domain
HA039_RS13655	COG0501	Belongs to the peptidase M48B family
HA039_RS13660	COG1007	ATP synthesis coupled electron transport
HA039_RS13670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HA039_RS13675	COG0713	ATP synthesis coupled electron transport
HA039_RS13690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HA039_RS13700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA039_RS13705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA039_RS13725	COG0674	pyruvate-flavodoxin oxidoreductase activity
HA039_RS13725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HA039_RS13730	COG1013	pyruvate-flavodoxin oxidoreductase activity
HA039_RS13735	COG1733	regulation of RNA biosynthetic process
HA039_RS13740	COG0702	epimerase
HA039_RS13755	COG1733	regulation of RNA biosynthetic process
HA039_RS13760	COG5434	Belongs to the glycosyl hydrolase 28 family
HA039_RS13765	COG4935	Belongs to the peptidase S8 family
HA039_RS13765	COG2234	aminopeptidase activity
HA039_RS13795	COG0179	Fumarylacetoacetate (FAA) hydrolase
HA039_RS13840	COG1007	ATP synthesis coupled electron transport
HA039_RS13850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HA039_RS13855	COG0713	ATP synthesis coupled electron transport
HA039_RS13860	COG0839	Belongs to the complex I subunit 6 family
HA039_RS13865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA039_RS13870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HA039_RS13875	COG1034	ATP synthesis coupled electron transport
HA039_RS13880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HA039_RS13890	COG0649	NAD binding
HA039_RS13895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA039_RS13900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA039_RS13920	COG0583	DNA-binding transcription factor activity
HA039_RS13940	COG2226	methyltransferase
HA039_RS13950	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HA039_RS13960	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HA039_RS13980	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HA039_RS13985	COG1064	alcohol dehydrogenase
HA039_RS13995	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS14015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA039_RS14020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS14025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS14045	COG3851	Histidine kinase
HA039_RS14050	COG2197	response regulator
HA039_RS14060	COG0163	prenyltransferase activity
HA039_RS14070	COG0109	protoheme IX farnesyltransferase activity
HA039_RS14075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HA039_RS14090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HA039_RS14095	COG1333	cytochrome c biogenesis protein
HA039_RS14100	COG0785	Cytochrome C biogenesis protein
HA039_RS14115	COG0406	alpha-ribazole phosphatase activity
HA039_RS14120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HA039_RS14135	COG1216	Glycosyl transferase, family 2
HA039_RS14180	COG1785	Belongs to the alkaline phosphatase family
HA039_RS14250	COG1690	Belongs to the RtcB family
HA039_RS14270	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HA039_RS14275	COG0018	arginyl-trna synthetase
HA039_RS14320	COG0113	porphobilinogen synthase activity
HA039_RS14325	COG1648	precorrin-2 dehydrogenase activity
HA039_RS14325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HA039_RS14330	COG0181	hydroxymethylbilane synthase activity
HA039_RS14335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HA039_RS14340	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HA039_RS14390	COG0123	including yeast histone deacetylase and acetoin utilization protein
HA039_RS14395	COG0738	Major facilitator superfamily
HA039_RS14400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA039_RS14420	COG0180	Tryptophanyl-tRNA synthetase
HA039_RS14425	COG1335	isochorismatase
HA039_RS14430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HA039_RS14445	COG1129	ABC transporter
HA039_RS14445	COG0842	Transport permease protein
HA039_RS14455	COG1252	NADH dehydrogenase
HA039_RS14480	COG0129	dihydroxy-acid dehydratase activity
HA039_RS14490	COG1082	Xylose isomerase domain protein TIM barrel
HA039_RS14495	COG0248	Ppx GppA phosphatase
HA039_RS14515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA039_RS14520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HA039_RS14550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HA039_RS14560	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HA039_RS14570	COG1194	a g-specific adenine glycosylase
HA039_RS14575	COG1595	DNA-templated transcription, initiation
HA039_RS14585	COG0745	RESPONSE REGULATOR receiver
HA039_RS14590	COG2205	protein histidine kinase activity
HA039_RS14610	COG0739	heme binding
HA039_RS14630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HA039_RS14650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HA039_RS14660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HA039_RS14665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HA039_RS14680	COG2197	response regulator
HA039_RS14695	COG0649	NAD binding
HA039_RS14705	COG1732	Glycine betaine
HA039_RS14710	COG1174	glycine betaine transport
HA039_RS14715	COG1174	glycine betaine transport
HA039_RS14725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HA039_RS14735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HA039_RS14740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HA039_RS14750	COG0302	gtp cyclohydrolase
HA039_RS14765	COG0037	tRNA processing
HA039_RS14775	COG2027	D-alanyl-D-alanine carboxypeptidase
HA039_RS14780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HA039_RS14790	COG0586	Pfam SNARE associated Golgi protein
HA039_RS14800	COG0076	glutamate decarboxylase activity
HA039_RS14820	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS14840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HA039_RS14850	COG0254	rRNA binding
HA039_RS14855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HA039_RS14860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HA039_RS14865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HA039_RS14875	COG0110	maltose O-acetyltransferase activity
HA039_RS14885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HA039_RS14885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HA039_RS14915	COG1472	Belongs to the glycosyl hydrolase 3 family
HA039_RS14930	COG0019	diaminopimelate decarboxylase activity
HA039_RS14955	COG1335	isochorismatase
HA039_RS14985	COG1401	restriction endodeoxyribonuclease activity
HA039_RS15010	COG0596	Alpha beta hydrolase
HA039_RS15015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HA039_RS15030	COG1754	DNA topoisomerase type I activity
HA039_RS15030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HA039_RS15040	COG2890	protein-(glutamine-N5) methyltransferase activity
HA039_RS15055	COG1366	Belongs to the anti-sigma-factor antagonist family
HA039_RS15120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HA039_RS15125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HA039_RS15135	COG2267	carboxylic ester hydrolase activity
HA039_RS15165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA039_RS15175	COG0251	oxidation-reduction process
HA039_RS15190	COG0003	Pfam Anion-transporting ATPase
HA039_RS15205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HA039_RS15215	COG1408	metallophosphoesterase
HA039_RS15280	COG0464	growth
HA039_RS15300	COG1674	ftsk spoiiie
HA039_RS15325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HA039_RS15335	COG1132	(ABC) transporter
HA039_RS15360	COG1595	DNA-templated transcription, initiation
HA039_RS15395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HA039_RS15400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HA039_RS15415	COG0463	Glycosyl transferase, family 2
HA039_RS15420	COG1802	Transcriptional regulator
HA039_RS15430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HA039_RS15450	COG3153	acetyltransferase
HA039_RS15475	COG0789	Transcriptional regulator
HA039_RS15480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HA039_RS15530	COG2807	transmembrane transport
HA039_RS15570	COG1414	Transcriptional regulator
HA039_RS15580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HA039_RS15615	COG2197	response regulator
HA039_RS15620	COG4585	Histidine kinase
HA039_RS15630	COG3844	kynureninase activity
HA039_RS15635	COG3483	tryptophan 2,3-dioxygenase activity
HA039_RS15660	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HA039_RS15665	COG0191	fructose-bisphosphate aldolase activity
HA039_RS15670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HA039_RS15685	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HA039_RS15715	COG0542	response to heat
HA039_RS15740	COG0789	Transcriptional regulator
HA039_RS15745	COG0484	heat shock protein binding
HA039_RS15750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HA039_RS15755	COG0443	Heat shock 70 kDa protein
HA039_RS15760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HA039_RS15765	COG2181	nitrate reductase activity
HA039_RS15765	COG0247	lactate metabolic process
HA039_RS15775	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HA039_RS15780	COG0717	Belongs to the dCTP deaminase family
HA039_RS15810	COG3345	alpha-galactosidase
HA039_RS15815	COG4977	sequence-specific DNA binding
HA039_RS15850	COG5183	chlorophyll binding
HA039_RS15850	COG2133	pyrroloquinoline quinone binding
HA039_RS15870	COG0187	DNA topoisomerase II activity
HA039_RS15945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HA039_RS15985	COG2226	methyltransferase
HA039_RS16035	COG3046	protein related to deoxyribodipyrimidine photolyase
HA039_RS16060	COG0714	Associated with various cellular activities
HA039_RS16085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HA039_RS16105	COG2197	response regulator
HA039_RS16130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HA039_RS16135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS16140	COG1120	ATPase activity
HA039_RS16165	COG4608	Belongs to the ABC transporter superfamily
HA039_RS16180	COG0601	transmembrane transport
HA039_RS16185	COG4166	transmembrane transport
HA039_RS16205	COG0583	DNA-binding transcription factor activity
HA039_RS16215	COG2318	DinB family
HA039_RS16275	COG0297	glycogen (starch) synthase activity
HA039_RS16290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HA039_RS16290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HA039_RS16295	COG1402	creatininase
HA039_RS16300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HA039_RS16305	COG1136	(ABC) transporter
HA039_RS16355	COG2268	Band 7 protein
HA039_RS16375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HA039_RS16510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS16575	COG1289	transmembrane transporter activity
HA039_RS16610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HA039_RS16620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HA039_RS16635	COG1741	Belongs to the pirin family
HA039_RS16645	COG1960	acyl-CoA dehydrogenase activity
HA039_RS16650	COG1362	aminopeptidase activity
HA039_RS16700	COG0508	dehydrogenase complex catalyzes the overall conversion of
HA039_RS16705	COG0022	dehydrogenase e1 component
HA039_RS16730	COG0515	serine threonine protein kinase
HA039_RS16735	COG0515	serine threonine protein kinase
HA039_RS16750	COG4591	ABC-type transport system involved in lipoprotein release permease component
HA039_RS16750	COG1136	(ABC) transporter
HA039_RS16770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HA039_RS16800	COG1522	sequence-specific DNA binding
HA039_RS16805	COG1309	transcriptional regulator
HA039_RS16810	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA039_RS16835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HA039_RS16850	COG1733	regulation of RNA biosynthetic process
HA039_RS16855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HA039_RS16870	COG1716	ATPase activity
HA039_RS16875	COG1716	ATPase activity
HA039_RS16890	COG0768	penicillin binding
HA039_RS16895	COG0515	serine threonine protein kinase
HA039_RS16900	COG3764	Sortase (surface protein transpeptidase)
HA039_RS16905	COG3764	Sortase (surface protein transpeptidase)
HA039_RS16930	COG0705	Rhomboid family
HA039_RS16955	COG0165	Argininosuccinate lyase
HA039_RS16965	COG1181	Belongs to the D-alanine--D-alanine ligase family
HA039_RS17000	COG0515	serine threonine protein kinase
HA039_RS17035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HA039_RS17045	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HA039_RS17050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HA039_RS17055	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HA039_RS17060	COG0592	DNA-directed DNA polymerase activity
HA039_RS17070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HA039_RS17080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HA039_RS17085	COG0706	membrane insertase activity
HA039_RS17095	COG0357	Ribosomal RNA small subunit methyltransferase G
HA039_RS17100	COG1192	Involved in chromosome partitioning
HA039_RS17115	COG3118	belongs to the thioredoxin family
HA039_RS17120	COG0492	ferredoxin-NADP+ reductase activity
HA039_RS17130	COG1595	DNA-templated transcription, initiation
HA039_RS17135	COG2815	serine threonine protein kinase
HA039_RS17135	COG0515	serine threonine protein kinase
HA039_RS17150	COG0617	tRNA 3'-terminal CCA addition
HA039_RS17170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HA039_RS17185	COG2348	transferase activity, transferring amino-acyl groups
HA039_RS17195	COG0360	Binds together with S18 to 16S ribosomal RNA
HA039_RS17200	COG0629	single-stranded DNA binding
HA039_RS17205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HA039_RS17210	COG0359	binds to the 23S rRNA
HA039_RS17220	COG0305	Participates in initiation and elongation during chromosome replication
HA039_RS17280	COG0626	cystathionine gamma-synthase activity
HA039_RS17285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HA039_RS17290	COG1950	PFAM Membrane protein of
HA039_RS17295	COG0662	Cupin 2, conserved barrel domain protein
HA039_RS17320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HA039_RS17335	COG1609	Transcriptional regulator
HA039_RS17340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HA039_RS17345	COG1271	oxidase subunit
HA039_RS17350	COG1294	oxidase, subunit
HA039_RS17355	COG4988	ABC transporter
HA039_RS17365	COG0561	phosphatase activity
HA039_RS17370	COG0326	Molecular chaperone. Has ATPase activity
HA039_RS17390	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HA039_RS17445	COG0561	phosphatase activity
HA039_RS17450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HA039_RS17460	COG2837	iron assimilation
HA039_RS17465	COG2372	response to copper ion
HA039_RS17470	COG2847	Copper chaperone PCu(A)C
HA039_RS17495	COG0006	proline dipeptidase activity
HA039_RS17515	COG0653	protein targeting
HA039_RS17555	COG0148	phosphopyruvate hydratase activity
HA039_RS17590	COG1595	DNA-templated transcription, initiation
HA039_RS17595	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS17600	COG0784	Response regulator, receiver
HA039_RS17640	COG2318	DinB family
HA039_RS17655	COG0745	RESPONSE REGULATOR receiver
HA039_RS17665	COG3467	pyridoxamine 5'-phosphate
HA039_RS17670	COG2353	YceI-like domain
HA039_RS17690	COG1191	sigma factor activity
HA039_RS17695	COG1191	sigma factor activity
HA039_RS17730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HA039_RS17775	COG0431	NADPH-dependent FMN reductase
HA039_RS17785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS17830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HA039_RS17835	COG1454	alcohol dehydrogenase
HA039_RS17870	COG0515	serine threonine protein kinase
HA039_RS17875	COG0438	transferase activity, transferring glycosyl groups
HA039_RS17875	COG1216	Glycosyl transferase, family 2
HA039_RS17890	COG0668	transmembrane transport
HA039_RS17910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HA039_RS17915	COG0270	DNA (cytosine-5-)-methyltransferase activity
HA039_RS17925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HA039_RS17955	COG1233	COG1233 Phytoene dehydrogenase and related
HA039_RS18025	COG0151	Belongs to the GarS family
HA039_RS18045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HA039_RS18055	COG2197	response regulator
HA039_RS18090	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HA039_RS18095	COG0047	phosphoribosylformylglycinamidine synthase activity
HA039_RS18100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HA039_RS18135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HA039_RS18165	COG1643	Atp-dependent helicase
HA039_RS18195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HA039_RS18200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HA039_RS18210	COG0513	Belongs to the DEAD box helicase family
HA039_RS18240	COG0189	ligase activity
HA039_RS18280	COG0667	Aldo Keto reductase
HA039_RS18290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HA039_RS18295	COG0579	oxidoreductase
HA039_RS18320	COG1252	NADH dehydrogenase
HA039_RS18335	COG1846	Transcriptional regulator
HA039_RS18410	COG0739	heme binding
HA039_RS18410	COG0741	lytic transglycosylase activity
HA039_RS18410	COG1196	nuclear chromosome segregation
HA039_RS18415	COG0671	phosphoesterase, PA-phosphatase related
HA039_RS18430	COG0277	FAD linked oxidase domain protein
HA039_RS18450	COG1937	Protein conserved in bacteria
HA039_RS18460	COG0306	phosphate transporter
HA039_RS18495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HA039_RS18515	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS18525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HA039_RS18550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HA039_RS18555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA039_RS18560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS18565	COG3629	intracellular signal transduction
HA039_RS18605	COG0456	acetyltransferase
HA039_RS18610	COG0737	Belongs to the 5'-nucleotidase family
HA039_RS18620	COG2205	protein histidine kinase activity
HA039_RS18630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HA039_RS18635	COG1609	Transcriptional regulator
HA039_RS18640	COG0745	RESPONSE REGULATOR receiver
HA039_RS18665	COG2897	thiosulfate sulfurtransferase activity
HA039_RS18710	COG3485	protocatechuate 3,4-dioxygenase
HA039_RS18715	COG0735	belongs to the Fur family
HA039_RS18720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HA039_RS18725	COG1490	D-aminoacyl-tRNA deacylase activity
HA039_RS18740	COG4552	Acetyltransferase involved in intracellular survival and related
HA039_RS18785	COG2124	cytochrome p450
HA039_RS18805	COG1595	DNA-templated transcription, initiation
HA039_RS18810	COG2814	Major facilitator Superfamily
HA039_RS18815	COG0789	Transcriptional regulator
HA039_RS18820	COG0789	Transcriptional regulator
HA039_RS18830	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS18835	COG3973	AAA domain
HA039_RS18840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HA039_RS18865	COG1595	DNA-templated transcription, initiation
HA039_RS18900	COG0438	transferase activity, transferring glycosyl groups
HA039_RS18945	COG0667	Aldo Keto reductase
HA039_RS18950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS18970	COG0588	phosphoglycerate mutase activity
HA039_RS19040	COG5002	protein histidine kinase activity
HA039_RS19060	COG1329	Transcriptional regulator
HA039_RS19065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HA039_RS19070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HA039_RS19080	COG0215	cysteine-tRNA ligase activity
HA039_RS19085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HA039_RS19110	COG3842	ATPase activity
HA039_RS19175	COG4257	antibiotic catabolic process
HA039_RS19210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HA039_RS19210	COG1017	nitric oxide dioxygenase activity
HA039_RS19225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA039_RS19290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HA039_RS19340	COG1877	trehalose-phosphatase activity
HA039_RS19340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA039_RS19355	COG0463	Glycosyl transferase, family 2
HA039_RS19365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HA039_RS19375	COG0459	protein refolding
HA039_RS19395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HA039_RS19400	COG1737	Transcriptional regulator
HA039_RS19455	COG3973	AAA domain
HA039_RS19470	COG1061	Type III restriction enzyme res subunit
HA039_RS19490	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HA039_RS19505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS19510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS19525	COG1278	Cold shock
HA039_RS19530	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HA039_RS19535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HA039_RS19545	COG2814	Major facilitator Superfamily
HA039_RS19600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HA039_RS19635	COG0667	Aldo Keto reductase
HA039_RS19640	COG2267	carboxylic ester hydrolase activity
HA039_RS19700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HA039_RS19710	COG0277	FAD linked oxidase domain protein
HA039_RS19710	COG0247	lactate metabolic process
HA039_RS19715	COG0583	DNA-binding transcription factor activity
HA039_RS19745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HA039_RS19760	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS19780	COG0259	pyridoxamine-phosphate oxidase activity
HA039_RS19800	COG4821	SIS domain
HA039_RS19810	COG2945	thiolester hydrolase activity
HA039_RS19810	COG0596	Alpha beta hydrolase
HA039_RS19850	COG0702	epimerase
HA039_RS19880	COG1366	Belongs to the anti-sigma-factor antagonist family
HA039_RS19910	COG2072	flavoprotein involved in K transport
HA039_RS19925	COG0259	pyridoxamine-phosphate oxidase activity
HA039_RS19930	COG1309	transcriptional regulator
HA039_RS19940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HA039_RS19940	COG0515	serine threonine protein kinase
HA039_RS19945	COG1595	DNA-templated transcription, initiation
HA039_RS19950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA039_RS20010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HA039_RS20050	COG1686	Belongs to the peptidase S11 family
HA039_RS20120	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS20140	COG1846	Transcriptional regulator
HA039_RS20145	COG3384	dioxygenase
HA039_RS20165	COG0477	Major facilitator Superfamily
HA039_RS20170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HA039_RS20190	COG1970	mechanosensitive ion channel activity
HA039_RS20200	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HA039_RS20215	COG3263	regulation of cellular component size
HA039_RS20225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HA039_RS20230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HA039_RS20240	COG0315	cyclic pyranopterin monophosphate synthase activity
HA039_RS20245	COG0521	Mo-molybdopterin cofactor biosynthetic process
HA039_RS20325	COG0438	transferase activity, transferring glycosyl groups
HA039_RS20330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HA039_RS20350	COG0297	glycogen (starch) synthase activity
HA039_RS20395	COG1316	TRANSCRIPTIONal
HA039_RS20480	COG2072	flavoprotein involved in K transport
HA039_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS20500	COG4946	Tricorn protease homolog
HA039_RS20500	COG0793	Belongs to the peptidase S41A family
HA039_RS20510	COG2409	Drug exporters of the RND superfamily
HA039_RS20515	COG3629	intracellular signal transduction
HA039_RS20515	COG3903	Transcriptional regulator
HA039_RS20520	COG2423	ornithine cyclodeaminase activity
HA039_RS20530	COG0512	Glutamine amidotransferase of anthranilate synthase
HA039_RS20535	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HA039_RS20545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HA039_RS20550	COG0475	glutathione-regulated potassium exporter activity
HA039_RS20565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HA039_RS20570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA039_RS20585	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS20620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HA039_RS20690	COG0577	efflux transmembrane transporter activity
HA039_RS20690	COG1136	(ABC) transporter
HA039_RS20695	COG1136	(ABC) transporter
HA039_RS20695	COG0577	efflux transmembrane transporter activity
HA039_RS20700	COG2175	clavaminate synthase activity
HA039_RS20725	COG0310	cobalt ion transport
HA039_RS20735	COG1122	ATPase activity
HA039_RS20825	COG0084	hydrolase, TatD family'
HA039_RS20840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HA039_RS20850	COG3550	peptidyl-serine autophosphorylation
HA039_RS20855	COG0488	(ABC) transporter
HA039_RS20895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HA039_RS20905	COG2197	response regulator
HA039_RS20915	COG4106	trans-aconitate 2-methyltransferase activity
HA039_RS20925	COG1309	transcriptional regulator
HA039_RS20935	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HA039_RS20945	COG0193	aminoacyl-tRNA hydrolase activity
HA039_RS20950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HA039_RS20955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HA039_RS20960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HA039_RS20975	COG3851	Histidine kinase
HA039_RS21005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HA039_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS21025	COG0477	Major facilitator Superfamily
HA039_RS21030	COG1136	(ABC) transporter
HA039_RS21035	COG0577	efflux transmembrane transporter activity
HA039_RS21125	COG0515	serine threonine protein kinase
HA039_RS21125	COG2815	serine threonine protein kinase
HA039_RS21145	COG2124	cytochrome p450
HA039_RS21150	COG1652	LysM domain
HA039_RS21160	COG0148	phosphopyruvate hydratase activity
HA039_RS21185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HA039_RS21190	COG0577	efflux transmembrane transporter activity
HA039_RS21190	COG1136	(ABC) transporter
HA039_RS21195	COG1136	(ABC) transporter
HA039_RS21220	COG0183	Belongs to the thiolase family
HA039_RS21225	COG2755	lipolytic protein G-D-S-L family
HA039_RS21305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HA039_RS21320	COG1228	amidohydrolase
HA039_RS21365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HA039_RS21370	COG1191	sigma factor activity
HA039_RS21385	COG0745	RESPONSE REGULATOR receiver
HA039_RS21390	COG2205	protein histidine kinase activity
HA039_RS21415	COG5002	protein histidine kinase activity
HA039_RS21420	COG0745	RESPONSE REGULATOR receiver
HA039_RS21430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HA039_RS21440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HA039_RS21460	COG1316	TRANSCRIPTIONal
HA039_RS21465	COG1607	acyl-coa hydrolase
HA039_RS21475	COG1316	TRANSCRIPTIONal
HA039_RS21480	COG1316	TRANSCRIPTIONal
HA039_RS21485	COG1316	TRANSCRIPTIONal
HA039_RS21540	COG0778	Nitroreductase
HA039_RS21540	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HA039_RS21545	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HA039_RS21595	COG1620	l-lactate permease
HA039_RS21600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HA039_RS21605	COG2835	tetraacyldisaccharide 4'-kinase activity
HA039_RS21615	COG1482	cell wall glycoprotein biosynthetic process
HA039_RS21625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HA039_RS21665	COG0714	Associated with various cellular activities
HA039_RS21685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HA039_RS21690	COG0745	RESPONSE REGULATOR receiver
HA039_RS21695	COG5000	phosphorelay sensor kinase activity
HA039_RS21695	COG5002	protein histidine kinase activity
HA039_RS21700	COG0823	Involved in the tonB-independent uptake of proteins
HA039_RS21710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HA039_RS21715	COG2197	response regulator
HA039_RS21720	COG3214	Protein conserved in bacteria
HA039_RS21730	COG0653	protein targeting
HA039_RS21750	COG2902	Dehydrogenase
HA039_RS21775	COG1216	Glycosyl transferase, family 2
HA039_RS21780	COG0395	ABC-type sugar transport system, permease component
HA039_RS21795	COG1674	ftsk spoiiie
HA039_RS21800	COG0515	serine threonine protein kinase
HA039_RS21805	COG0515	serine threonine protein kinase
HA039_RS21810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HA039_RS21825	COG2884	Cell division ATP-binding protein ftsE
HA039_RS21835	COG0793	Belongs to the peptidase S41A family
HA039_RS21840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HA039_RS21855	COG0583	DNA-binding transcription factor activity
HA039_RS21910	COG3973	AAA domain
HA039_RS21920	COG0776	regulation of translation
HA039_RS21925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HA039_RS21930	COG1678	Uncharacterized ACR, COG1678
HA039_RS21945	COG1175	transmembrane transport
HA039_RS21950	COG0395	ABC-type sugar transport system, permease component
HA039_RS21955	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HA039_RS21970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HA039_RS22045	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HA039_RS22055	COG0277	FAD linked oxidase domain protein
HA039_RS22090	COG1335	isochorismatase
HA039_RS22105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HA039_RS22115	COG1113	amino acid transport
HA039_RS22130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS22135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HA039_RS22155	COG1234	tRNA 3'-trailer cleavage
HA039_RS22160	COG1263	PTS System
HA039_RS22165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA039_RS22170	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HA039_RS22180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HA039_RS22220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HA039_RS22225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HA039_RS22240	COG4555	ABC transporter
HA039_RS22255	COG2733	membrane
HA039_RS22285	COG1074	ATP-dependent DNA helicase activity
HA039_RS22345	COG0706	membrane insertase activity
HA039_RS22355	COG4702	Belongs to the UPF0303 family
HA039_RS22360	COG0673	inositol 2-dehydrogenase activity
HA039_RS22410	COG3397	chitin binding
HA039_RS22420	COG0577	efflux transmembrane transporter activity
HA039_RS22420	COG1136	(ABC) transporter
HA039_RS22440	COG2755	lipolytic protein G-D-S-L family
HA039_RS22450	COG0154	amidase activity
HA039_RS22465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS22610	COG0406	alpha-ribazole phosphatase activity
HA039_RS22655	COG0745	RESPONSE REGULATOR receiver
HA039_RS22705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HA039_RS22710	COG4977	sequence-specific DNA binding
HA039_RS22720	COG0589	response to stress
HA039_RS22730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HA039_RS22750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HA039_RS22765	COG1960	acyl-CoA dehydrogenase activity
HA039_RS22780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HA039_RS22785	COG1309	transcriptional regulator
HA039_RS22795	COG1946	Acyl-CoA thioesterase
HA039_RS22805	COG0431	NADPH-dependent FMN reductase
HA039_RS22815	COG3960	tartronate-semialdehyde synthase activity
HA039_RS22865	COG0673	inositol 2-dehydrogenase activity
HA039_RS22880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HA039_RS22905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA039_RS22915	COG3718	enzyme involved in inositol metabolism
HA039_RS22920	COG3962	Belongs to the TPP enzyme family
HA039_RS22935	COG1733	regulation of RNA biosynthetic process
HA039_RS22945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HA039_RS23005	COG0494	nUDIX hydrolase
HA039_RS23025	COG0454	-acetyltransferase
HA039_RS23075	COG0693	protein deglycase activity
HA039_RS23095	COG0629	single-stranded DNA binding
HA039_RS23130	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HA039_RS23160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA039_RS23175	COG1486	melibiose metabolic process
HA039_RS23180	COG0395	ABC-type sugar transport system, permease component
HA039_RS23185	COG1175	transmembrane transport
HA039_RS23195	COG1846	Transcriptional regulator
HA039_RS23195	COG1940	carbohydrate kinase activity
HA039_RS23200	COG0668	transmembrane transport
HA039_RS23230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HA039_RS23290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HA039_RS23295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HA039_RS23315	COG4552	Acetyltransferase involved in intracellular survival and related
HA039_RS23330	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS23335	COG0475	glutathione-regulated potassium exporter activity
HA039_RS23340	COG1136	(ABC) transporter
HA039_RS23340	COG0577	efflux transmembrane transporter activity
HA039_RS23365	COG0544	peptidyl-prolyl cis-trans isomerase activity
HA039_RS23370	COG0740	serine-type endopeptidase activity
HA039_RS23375	COG0740	serine-type endopeptidase activity
HA039_RS23380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HA039_RS23390	COG0525	valine-tRNA ligase activity
HA039_RS23395	COG0285	dihydrofolate synthase activity
HA039_RS23405	COG0105	UTP biosynthetic process
HA039_RS23410	COG1077	Cell shape determining protein MreB Mrl
HA039_RS23425	COG0768	penicillin binding
HA039_RS23430	COG0772	Belongs to the SEDS family
HA039_RS23465	COG2226	methyltransferase
HA039_RS23485	COG1530	ribonuclease E activity
HA039_RS23490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HA039_RS23495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HA039_RS23500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HA039_RS23550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HA039_RS23560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HA039_RS23575	COG0501	Belongs to the peptidase M48B family
HA039_RS23590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HA039_RS23600	COG0799	negative regulation of ribosome biogenesis
HA039_RS23605	COG0588	phosphoglycerate mutase activity
HA039_RS23620	COG0477	Major facilitator Superfamily
HA039_RS23640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HA039_RS23650	COG0495	leucyl-tRNA aminoacylation
HA039_RS23660	COG1307	EDD domain protein, DegV family
HA039_RS23665	COG1555	photosystem II stabilization
HA039_RS23670	COG1234	tRNA 3'-trailer cleavage
HA039_RS23675	COG2353	YceI-like domain
HA039_RS23690	COG0268	Binds directly to 16S ribosomal RNA
HA039_RS23695	COG0481	GTPase activity
HA039_RS23735	COG1420	regulation of RNA biosynthetic process
HA039_RS23740	COG0484	heat shock protein binding
HA039_RS23755	COG0537	adenosine 5'-monophosphoramidase activity
HA039_RS23760	COG1234	tRNA 3'-trailer cleavage
HA039_RS23765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HA039_RS23765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HA039_RS23775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HA039_RS23785	COG2315	Protein conserved in bacteria
HA039_RS23795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HA039_RS23815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HA039_RS23825	COG1381	Involved in DNA repair and RecF pathway recombination
HA039_RS23830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HA039_RS23840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA039_RS23845	COG1121	(ABC) transporter
HA039_RS23850	COG3443	Belongs to the bacterial solute-binding protein 9 family
HA039_RS23850	COG0803	Belongs to the bacterial solute-binding protein 9 family
HA039_RS23855	COG0423	glycine-tRNA ligase activity
HA039_RS23870	COG0667	Aldo Keto reductase
HA039_RS23890	COG0477	Major facilitator Superfamily
HA039_RS23960	COG2188	Transcriptional regulator
HA039_RS23980	COG3842	ATPase activity
HA039_RS23985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA039_RS23990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HA039_RS23990	COG0574	Belongs to the PEP-utilizing enzyme family
HA039_RS24050	COG2949	membrane
HA039_RS24060	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HA039_RS24065	COG0714	Associated with various cellular activities
HA039_RS24090	COG3629	intracellular signal transduction
HA039_RS24090	COG3903	Transcriptional regulator
HA039_RS24095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HA039_RS24105	COG0358	DNA primase activity
HA039_RS24125	COG1070	Carbohydrate kinase
HA039_RS24150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS24165	COG0515	serine threonine protein kinase
HA039_RS24220	COG2130	NADP-dependent
HA039_RS24225	COG1764	response to oxidative stress
HA039_RS24245	COG1309	transcriptional regulator
HA039_RS24270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HA039_RS24275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA039_RS24280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA039_RS24285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HA039_RS24300	COG1741	Belongs to the pirin family
HA039_RS24315	COG0789	Transcriptional regulator
HA039_RS24320	COG0667	Aldo Keto reductase
HA039_RS24335	COG1309	transcriptional regulator
HA039_RS24340	COG0477	Major facilitator Superfamily
HA039_RS24350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HA039_RS24400	COG1358	cellular component organization or biogenesis
HA039_RS24445	COG1595	DNA-templated transcription, initiation
HA039_RS24450	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HA039_RS24450	COG3608	succinylglutamate desuccinylase aspartoacylase
HA039_RS24535	COG0438	transferase activity, transferring glycosyl groups
HA039_RS24575	COG2814	Major facilitator Superfamily
HA039_RS24585	COG2197	response regulator
HA039_RS24590	COG4585	Histidine kinase
HA039_RS24600	COG1131	(ABC) transporter
HA039_RS24615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HA039_RS24620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HA039_RS24635	COG0800	Aldolase
HA039_RS24640	COG3022	response to hydroperoxide
HA039_RS24680	COG1119	ATPase activity
HA039_RS24690	COG1716	ATPase activity
HA039_RS24710	COG0384	phenazine biosynthesis protein PhzF
HA039_RS24720	COG3540	Alkaline phosphatase
HA039_RS24730	COG2814	Major facilitator Superfamily
HA039_RS24765	COG0672	)-iron permease
HA039_RS24770	COG2837	iron assimilation
HA039_RS24785	COG5398	heme oxygenase
HA039_RS24820	COG1994	Peptidase M50
HA039_RS24840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HA039_RS24845	COG0477	Major facilitator Superfamily
HA039_RS24860	COG2814	Major facilitator Superfamily
HA039_RS24865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HA039_RS24865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HA039_RS24890	COG1846	Transcriptional regulator
HA039_RS24895	COG0174	glutamine synthetase
HA039_RS24915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HA039_RS24925	COG1609	Transcriptional regulator
HA039_RS24930	COG2182	Extracellular solute-binding protein
HA039_RS24935	COG1175	transmembrane transport
HA039_RS24940	COG0395	ABC-type sugar transport system, permease component
HA039_RS24945	COG0366	Alpha amylase catalytic
HA039_RS24985	COG2197	response regulator
HA039_RS25015	COG0745	RESPONSE REGULATOR receiver
HA039_RS25050	COG1595	DNA-templated transcription, initiation
HA039_RS25105	COG2815	serine threonine protein kinase
HA039_RS25105	COG0515	serine threonine protein kinase
HA039_RS25150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HA039_RS25155	COG0321	lipoyl(octanoyl) transferase activity
HA039_RS25185	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS25195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HA039_RS25205	COG0508	dehydrogenase complex catalyzes the overall conversion of
HA039_RS25210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA039_RS25215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HA039_RS25220	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HA039_RS25230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HA039_RS25245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HA039_RS25255	COG2226	methyltransferase
HA039_RS25280	COG2197	response regulator
HA039_RS25285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA039_RS25290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HA039_RS25310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA039_RS25320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HA039_RS25325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HA039_RS25335	COG1376	ErfK ybiS ycfS ynhG family protein
HA039_RS25345	COG1845	cytochrome c oxidase, subunit III
HA039_RS25350	COG2010	Cytochrome c
HA039_RS25355	COG0723	plastoquinol--plastocyanin reductase activity
HA039_RS25360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HA039_RS25365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HA039_RS25370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HA039_RS25395	COG0791	NLP P60 protein
HA039_RS25395	COG0741	lytic transglycosylase activity
HA039_RS25415	COG0438	transferase activity, transferring glycosyl groups
HA039_RS25435	COG0003	Pfam Anion-transporting ATPase
HA039_RS25445	COG1940	carbohydrate kinase activity
HA039_RS25470	COG4585	Histidine kinase
HA039_RS25475	COG2197	response regulator
HA039_RS25485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HA039_RS25495	COG2193	ferroxidase activity
HA039_RS25500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HA039_RS25505	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HA039_RS25510	COG0515	serine threonine protein kinase
HA039_RS25510	COG2815	serine threonine protein kinase
HA039_RS25515	COG2022	thiamine diphosphate biosynthetic process
HA039_RS25525	COG2022	thiamine diphosphate biosynthetic process
HA039_RS25525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA039_RS25535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HA039_RS25545	COG0352	thiamine-phosphate diphosphorylase activity
HA039_RS25560	COG1233	COG1233 Phytoene dehydrogenase and related
HA039_RS25570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HA039_RS25590	COG0714	Associated with various cellular activities
HA039_RS25600	COG0275	rRNA processing
HA039_RS25615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HA039_RS25625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HA039_RS25630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HA039_RS25640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HA039_RS25645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HA039_RS25665	COG1799	cell septum assembly
HA039_RS25675	COG3599	regulation of cell shape
HA039_RS25680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HA039_RS25695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HA039_RS25735	COG0587	DNA-directed DNA polymerase activity
HA039_RS25745	COG1432	Conserved Protein
HA039_RS25765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HA039_RS25785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HA039_RS25790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HA039_RS25795	COG0131	Imidazoleglycerol-phosphate dehydratase
HA039_RS25805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HA039_RS25810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HA039_RS25815	COG0251	oxidation-reduction process
HA039_RS25820	COG0107	imidazoleglycerol-phosphate synthase activity
HA039_RS25840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HA039_RS25845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HA039_RS25865	COG0134	indole-3-glycerol-phosphate synthase activity
HA039_RS25875	COG0133	tryptophan synthase activity
HA039_RS25880	COG0159	tryptophan synthase activity
HA039_RS25890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HA039_RS25900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HA039_RS25905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA039_RS25935	COG0070	glutamate synthase
HA039_RS25935	COG0067	glutamate synthase
HA039_RS25935	COG0069	glutamate synthase activity
HA039_RS25960	COG1278	Cold shock
HA039_RS25965	COG0513	Belongs to the DEAD box helicase family
HA039_RS25980	COG1733	regulation of RNA biosynthetic process
HA039_RS26005	COG1605	Chorismate mutase
HA039_RS26005	COG0287	Prephenate dehydrogenase
HA039_RS26025	COG0737	Belongs to the 5'-nucleotidase family
HA039_RS26085	COG2050	protein possibly involved in aromatic compounds catabolism
HA039_RS26105	COG1643	Atp-dependent helicase
HA039_RS26110	COG2226	methyltransferase
HA039_RS26135	COG1404	Belongs to the peptidase S8 family
HA039_RS26140	COG0237	dephospho-CoA kinase activity
HA039_RS26170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HA039_RS26180	COG2124	cytochrome p450
HA039_RS26195	COG0436	Aminotransferase
HA039_RS26225	COG2313	pseudouridylate synthase activity
HA039_RS26230	COG1063	alcohol dehydrogenase
HA039_RS26235	COG0584	glycerophosphoryl diester phosphodiesterase
HA039_RS26245	COG0556	nucleotide-excision repair
HA039_RS26285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA039_RS26310	COG0322	excinuclease ABC activity
HA039_RS26315	COG1660	Displays ATPase and GTPase activities
HA039_RS26320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HA039_RS26325	COG1481	regulation of sporulation
HA039_RS26335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HA039_RS26340	COG0126	phosphoglycerate kinase activity
HA039_RS26345	COG0149	triose-phosphate isomerase activity
HA039_RS26350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HA039_RS26365	COG0166	Belongs to the GPI family
HA039_RS26380	COG0363	glucosamine-6-phosphate deaminase activity
HA039_RS26395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HA039_RS26405	COG0109	protoheme IX farnesyltransferase activity
HA039_RS26445	COG0719	Fe-S assembly protein
HA039_RS26455	COG0396	ATPase activity
HA039_RS26460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HA039_RS26465	COG0822	iron-sulfur transferase activity
HA039_RS26470	COG2151	metal-sulfur cluster biosynthetic enzyme
HA039_RS26475	COG2076	Multidrug Resistance protein
HA039_RS26480	COG3226	Transcriptional regulator
HA039_RS26490	COG2171	N-acyltransferase activity
HA039_RS26495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HA039_RS26515	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS26540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HA039_RS26545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HA039_RS26560	COG2252	PERMEase
HA039_RS26575	COG0768	penicillin binding
HA039_RS26580	COG1414	Transcriptional regulator
HA039_RS26630	COG1902	pentaerythritol trinitrate reductase activity
HA039_RS26675	COG1797	cobyrinic acid a,c-diamide synthase activity
HA039_RS26690	COG1492	cobalamin metabolic process
HA039_RS26710	COG0235	Class ii aldolase
HA039_RS26735	COG0488	(ABC) transporter
HA039_RS26745	COG1024	Enoyl-CoA hydratase
HA039_RS26800	COG2124	cytochrome p450
HA039_RS26810	COG3387	PFAM Glycoside hydrolase 15-related
HA039_RS26820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HA039_RS26830	COG1063	alcohol dehydrogenase
HA039_RS26845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HA039_RS26850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HA039_RS26865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HA039_RS26880	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS26885	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HA039_RS26895	COG2186	Transcriptional regulator
HA039_RS26900	COG2807	transmembrane transport
HA039_RS26915	COG0560	Phosphoserine phosphatase
HA039_RS26915	COG3830	Belongs to the UPF0237 family
HA039_RS26920	COG1131	(ABC) transporter
HA039_RS26920	COG0842	Transport permease protein
HA039_RS26920	COG1716	ATPase activity
HA039_RS26930	COG4585	Histidine kinase
HA039_RS26935	COG2197	response regulator
HA039_RS26955	COG1119	ATPase activity
HA039_RS26980	COG1881	PFAM PEBP family protein
HA039_RS26990	COG2094	Belongs to the DNA glycosylase MPG family
HA039_RS27020	COG0647	UMP catabolic process
HA039_RS27055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HA039_RS27060	COG0497	DNA recombination
HA039_RS27075	COG2226	methyltransferase
HA039_RS27080	COG3387	PFAM Glycoside hydrolase 15-related
HA039_RS27085	COG0504	CTP synthase activity
HA039_RS27090	COG0494	nUDIX hydrolase
HA039_RS27100	COG0686	Belongs to the AlaDH PNT family
HA039_RS27115	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HA039_RS27120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HA039_RS27125	COG1187	pseudouridine synthase activity
HA039_RS27150	COG3541	Predicted nucleotidyltransferase
HA039_RS27165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HA039_RS27175	COG1160	GTP binding
HA039_RS27190	COG0438	transferase activity, transferring glycosyl groups
HA039_RS27210	COG0671	phosphoesterase, PA-phosphatase related
HA039_RS27215	COG0477	Major facilitator Superfamily
HA039_RS27220	COG1960	acyl-CoA dehydrogenase activity
HA039_RS27225	COG1799	cell septum assembly
HA039_RS27240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS27275	COG0641	radical SAM
HA039_RS27295	COG2755	lipolytic protein G-D-S-L family
HA039_RS27310	COG0596	Alpha beta hydrolase
HA039_RS27325	COG0587	DNA-directed DNA polymerase activity
HA039_RS27330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HA039_RS27345	COG0644	oxidoreductase
HA039_RS27360	COG0300	oxidoreductase activity
HA039_RS27360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA039_RS27360	COG4221	oxidoreductase activity
HA039_RS27360	COG3321	synthase
HA039_RS27370	COG4335	DNA alkylation repair
HA039_RS27375	COG0156	8-amino-7-oxononanoate synthase activity
HA039_RS27390	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HA039_RS27395	COG0477	Major facilitator Superfamily
HA039_RS27405	COG2201	protein-glutamate methylesterase activity
HA039_RS27425	COG0346	lactoylglutathione lyase activity
HA039_RS27435	COG1725	Transcriptional regulator
HA039_RS27450	COG1216	Glycosyl transferase, family 2
HA039_RS27460	COG2755	lipolytic protein G-D-S-L family
HA039_RS27490	COG2188	Transcriptional regulator
HA039_RS27495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HA039_RS27500	COG1309	transcriptional regulator
HA039_RS27505	COG0243	molybdopterin cofactor binding
HA039_RS27505	COG0243	molybdopterin cofactor binding
HA039_RS27510	COG3842	ATPase activity
HA039_RS27535	COG1960	acyl-CoA dehydrogenase activity
HA039_RS27575	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS27580	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS27595	COG1960	acyl-CoA dehydrogenase activity
HA039_RS27605	COG4948	Mandelate Racemase Muconate Lactonizing
HA039_RS27620	COG2149	membrane
HA039_RS27625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HA039_RS27630	COG3573	Dehydrogenase
HA039_RS27650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HA039_RS27660	COG3265	gluconokinase activity
HA039_RS27675	COG0564	pseudouridine synthase activity
HA039_RS27730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA039_RS27760	COG0667	Aldo Keto reductase
HA039_RS27765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS27775	COG0598	Magnesium transport protein CorA
HA039_RS27795	COG0215	cysteine-tRNA ligase activity
HA039_RS27810	COG4948	Mandelate Racemase Muconate Lactonizing
HA039_RS27815	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS27825	COG1129	ABC transporter
HA039_RS27830	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA039_RS27835	COG2186	Transcriptional regulator
HA039_RS27840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HA039_RS27845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HA039_RS27850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HA039_RS27855	COG1414	Transcriptional regulator
HA039_RS27860	COG1410	methionine synthase
HA039_RS27860	COG0646	methionine synthase
HA039_RS27870	COG4166	transmembrane transport
HA039_RS27880	COG2197	response regulator
HA039_RS27890	COG0517	IMP dehydrogenase activity
HA039_RS27890	COG1994	Peptidase M50
HA039_RS27915	COG1222	aaa ATPase
HA039_RS27920	COG4122	O-methyltransferase activity
HA039_RS27935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HA039_RS27940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HA039_RS27955	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HA039_RS27990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HA039_RS27995	COG0805	protein transport
HA039_RS28020	COG3665	Urea carboxylase-associated protein
HA039_RS28030	COG1309	transcriptional regulator
HA039_RS28065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HA039_RS28085	COG1595	DNA-templated transcription, initiation
HA039_RS28095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HA039_RS28100	COG4175	Glycine betaine
HA039_RS28100	COG3448	diguanylate cyclase activity
HA039_RS28135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HA039_RS28140	COG0531	amino acid
HA039_RS28150	COG0174	glutamine synthetase
HA039_RS28155	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS28205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HA039_RS28210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HA039_RS28215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HA039_RS28220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HA039_RS28225	COG5002	protein histidine kinase activity
HA039_RS28230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HA039_RS28235	COG0072	phenylalanine-tRNA ligase activity
HA039_RS28235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HA039_RS28250	COG1051	belongs to the nudix hydrolase family
HA039_RS28260	COG1649	PFAM Uncharacterised BCR, COG1649
HA039_RS28275	COG0154	amidase activity
HA039_RS28280	COG0154	amidase activity
HA039_RS28310	COG0697	spore germination
HA039_RS28315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA039_RS28325	COG0514	ATP-dependent DNA helicase (RecQ)
HA039_RS28330	COG3708	Transcriptional regulator
HA039_RS28330	COG2207	Transcriptional regulator
HA039_RS28335	COG2045	Belongs to the ComB family
HA039_RS28340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HA039_RS28345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HA039_RS28355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HA039_RS28360	COG1438	arginine binding
HA039_RS28365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA039_RS28370	COG1397	ADP-ribosylglycohydrolase
HA039_RS28375	COG2188	Transcriptional regulator
HA039_RS28390	COG0137	argininosuccinate synthase activity
HA039_RS28395	COG0165	Argininosuccinate lyase
HA039_RS28410	COG0477	Major facilitator Superfamily
HA039_RS28415	COG0318	PFAM AMP-dependent synthetase and ligase
HA039_RS28415	COG0204	Acyl-transferase
HA039_RS28450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HA039_RS28455	COG2011	ABC-type metal ion transport system permease component
HA039_RS28460	COG1464	Belongs to the NlpA lipoprotein family
HA039_RS28475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HA039_RS28480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HA039_RS28480	COG1648	precorrin-2 dehydrogenase activity
HA039_RS28535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HA039_RS28545	COG0456	acetyltransferase
HA039_RS28595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HA039_RS28610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HA039_RS28615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HA039_RS28630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HA039_RS28635	COG1560	Kdo2-lipid A biosynthetic process
HA039_RS28640	COG0438	transferase activity, transferring glycosyl groups
HA039_RS28650	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HA039_RS28655	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HA039_RS28660	COG0217	transcriptional regulatory protein
HA039_RS28665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HA039_RS28670	COG0632	four-way junction helicase activity
HA039_RS28675	COG2255	four-way junction helicase activity
HA039_RS28685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HA039_RS28690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HA039_RS28695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HA039_RS28700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HA039_RS28705	COG1196	nuclear chromosome segregation
HA039_RS28720	COG0124	histidyl-tRNA synthetase
HA039_RS28740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HA039_RS28755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HA039_RS28760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HA039_RS28765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HA039_RS28770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HA039_RS28775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HA039_RS28780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HA039_RS28785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HA039_RS28790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HA039_RS28800	COG0006	proline dipeptidase activity
HA039_RS28805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HA039_RS28810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HA039_RS28820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HA039_RS28825	COG0540	Belongs to the ATCase OTCase family
HA039_RS28830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HA039_RS28840	COG0505	Belongs to the CarA family
HA039_RS28845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HA039_RS28850	COG0167	dihydroorotate dehydrogenase activity
HA039_RS28855	COG0284	orotidine-5'-phosphate decarboxylase activity
HA039_RS28870	COG1758	RNA polymerase activity
HA039_RS28880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HA039_RS28915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HA039_RS28925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HA039_RS28930	COG2390	Transcriptional regulator
HA039_RS28940	COG1191	sigma factor activity
HA039_RS28950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HA039_RS28970	COG0738	Major facilitator superfamily
HA039_RS28975	COG1846	Transcriptional regulator
HA039_RS28975	COG1940	carbohydrate kinase activity
HA039_RS28990	COG3201	nicotinamide mononucleotide transporter
HA039_RS28995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HA039_RS28995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HA039_RS29000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HA039_RS29005	COG0140	phosphoribosyl-ATP diphosphatase activity
HA039_RS29010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HA039_RS29055	COG1960	acyl-CoA dehydrogenase activity
HA039_RS29075	COG0463	Glycosyl transferase, family 2
HA039_RS29090	COG2270	Major facilitator Superfamily
HA039_RS29130	COG0438	transferase activity, transferring glycosyl groups
HA039_RS29145	COG1984	allophanate hydrolase subunit 2
HA039_RS29150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HA039_RS29155	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HA039_RS29160	COG2814	Major facilitator Superfamily
HA039_RS29195	COG2018	Roadblock/LC7 domain
HA039_RS29210	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HA039_RS29225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HA039_RS29235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HA039_RS29240	COG2190	(PTS) system
HA039_RS29265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HA039_RS29285	COG1716	ATPase activity
HA039_RS29305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HA039_RS29315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HA039_RS29315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HA039_RS29360	COG1695	Transcriptional regulator
HA039_RS29390	COG0697	spore germination
HA039_RS29410	COG1309	transcriptional regulator
HA039_RS29440	COG2172	sigma factor antagonist activity
HA039_RS29445	COG1366	Belongs to the anti-sigma-factor antagonist family
HA039_RS29450	COG1366	Belongs to the anti-sigma-factor antagonist family
HA039_RS29465	COG1120	ATPase activity
HA039_RS29470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS29490	COG1136	(ABC) transporter
HA039_RS29545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HA039_RS29560	COG2318	DinB family
HA039_RS29570	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HA039_RS29580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HA039_RS29605	COG1968	undecaprenyl-diphosphatase activity
HA039_RS29625	COG1024	Enoyl-CoA hydratase
HA039_RS29635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HA039_RS29675	COG2124	cytochrome p450
HA039_RS29715	COG1832	CoA-binding protein
HA039_RS29720	COG1739	Uncharacterized protein family UPF0029
HA039_RS29735	COG0420	3'-5' exonuclease activity
HA039_RS29740	COG0419	ATPase involved in DNA repair
HA039_RS29745	COG1522	sequence-specific DNA binding
HA039_RS29760	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS29775	COG2226	methyltransferase
HA039_RS29780	COG0640	Transcriptional regulator
HA039_RS29785	COG0798	PFAM Bile acid sodium symporter
HA039_RS29790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HA039_RS29815	COG2223	nitrite transmembrane transporter activity
HA039_RS29825	COG1595	DNA-templated transcription, initiation
HA039_RS29830	COG2188	Transcriptional regulator
HA039_RS29835	COG1940	carbohydrate kinase activity
HA039_RS29840	COG2197	response regulator
HA039_RS29845	COG4585	Histidine kinase
HA039_RS29870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HA039_RS29890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HA039_RS29895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HA039_RS29900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HA039_RS29935	COG0477	Major facilitator Superfamily
HA039_RS29970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HA039_RS29975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HA039_RS29980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HA039_RS29995	COG0791	NLP P60 protein
HA039_RS30005	COG0740	serine-type endopeptidase activity
HA039_RS30015	COG0831	urea catabolic process
HA039_RS30020	COG0832	Belongs to the urease beta subunit family
HA039_RS30025	COG0804	urea catabolic process
HA039_RS30035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HA039_RS30040	COG0829	nickel cation binding
HA039_RS30070	COG3254	rhamnose metabolic process
HA039_RS30075	COG2186	Transcriptional regulator
HA039_RS30085	COG4948	Mandelate Racemase Muconate Lactonizing
HA039_RS30095	COG1175	transmembrane transport
HA039_RS30100	COG0395	ABC-type sugar transport system, permease component
HA039_RS30105	COG0583	DNA-binding transcription factor activity
HA039_RS30110	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS30125	COG0681	Belongs to the peptidase S26 family
HA039_RS30135	COG2409	Drug exporters of the RND superfamily
HA039_RS30140	COG4585	Histidine kinase
HA039_RS30155	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HA039_RS30165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HA039_RS30170	COG1120	ATPase activity
HA039_RS30175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS30180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA039_RS30195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HA039_RS30200	COG1132	(ABC) transporter
HA039_RS30215	COG2268	Band 7 protein
HA039_RS30220	COG0640	Transcriptional regulator
HA039_RS30240	COG0205	6-phosphofructokinase activity
HA039_RS30245	COG3442	glutamine amidotransferase
HA039_RS30255	COG0242	peptide deformylase activity
HA039_RS30265	COG1960	acyl-CoA dehydrogenase activity
HA039_RS30270	COG0386	Belongs to the glutathione peroxidase family
HA039_RS30280	COG1946	Acyl-CoA thioesterase
HA039_RS30305	COG1132	(ABC) transporter
HA039_RS30310	COG1132	(ABC) transporter
HA039_RS30330	COG2072	flavoprotein involved in K transport
HA039_RS30335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS30345	COG1116	anion transmembrane transporter activity
HA039_RS30350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HA039_RS30355	COG0432	Pfam Uncharacterised protein family UPF0047
HA039_RS30370	COG4221	oxidoreductase activity
HA039_RS30385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HA039_RS30395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HA039_RS30400	COG2409	Drug exporters of the RND superfamily
HA039_RS30405	COG4221	oxidoreductase activity
HA039_RS30435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HA039_RS30440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HA039_RS30495	COG3963	phosphatidate phosphatase activity
HA039_RS30500	COG4585	Histidine kinase
HA039_RS30505	COG2197	response regulator
HA039_RS30515	COG0586	Pfam SNARE associated Golgi protein
HA039_RS30535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HA039_RS30595	COG1733	regulation of RNA biosynthetic process
HA039_RS30600	COG1024	Enoyl-CoA hydratase
HA039_RS30600	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA039_RS30610	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS30615	COG1733	regulation of RNA biosynthetic process
HA039_RS30650	COG2208	phosphoserine phosphatase activity
HA039_RS30650	COG2770	Histidine kinase
HA039_RS30655	COG1366	Belongs to the anti-sigma-factor antagonist family
HA039_RS30665	COG1408	metallophosphoesterase
HA039_RS30675	COG1309	transcriptional regulator
HA039_RS30685	COG0300	oxidoreductase activity
HA039_RS30700	COG0667	Aldo Keto reductase
HA039_RS30710	COG0604	alcohol dehydrogenase
HA039_RS30725	COG1902	pentaerythritol trinitrate reductase activity
HA039_RS30730	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS30735	COG0477	Major facilitator Superfamily
HA039_RS30740	COG3629	intracellular signal transduction
HA039_RS30740	COG3903	Transcriptional regulator
HA039_RS30760	COG0583	DNA-binding transcription factor activity
HA039_RS30765	COG1609	Transcriptional regulator
HA039_RS30785	COG1175	transmembrane transport
HA039_RS30790	COG0395	ABC-type sugar transport system, permease component
HA039_RS30795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA039_RS30815	COG4221	oxidoreductase activity
HA039_RS30830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA039_RS30835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HA039_RS30870	COG2197	response regulator
HA039_RS30880	COG1832	CoA-binding protein
HA039_RS30915	COG0009	L-threonylcarbamoyladenylate synthase
HA039_RS30920	COG0577	efflux transmembrane transporter activity
HA039_RS30920	COG1136	(ABC) transporter
HA039_RS30925	COG0577	efflux transmembrane transporter activity
HA039_RS30925	COG1136	(ABC) transporter
HA039_RS30945	COG2814	Major facilitator Superfamily
HA039_RS30960	COG3511	phospholipase C
HA039_RS31000	COG1819	glycosyl
HA039_RS31025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA039_RS31095	COG2319	Wd-40 repeat
HA039_RS31095	COG4249	Peptidase C14 caspase catalytic subunit p20
HA039_RS31110	COG5635	Nacht domain
HA039_RS31110	COG2319	Wd-40 repeat
HA039_RS31175	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HA039_RS31185	COG1309	transcriptional regulator
HA039_RS31190	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS31200	COG0667	Aldo Keto reductase
HA039_RS31205	COG0346	lactoylglutathione lyase activity
HA039_RS31210	COG2838	Isocitrate dehydrogenase
HA039_RS31220	COG0546	phosphoglycolate phosphatase activity
HA039_RS31225	COG2706	6-phosphogluconolactonase activity
HA039_RS31240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HA039_RS31245	COG1902	pentaerythritol trinitrate reductase activity
HA039_RS31250	COG0640	Transcriptional regulator
HA039_RS31280	COG0671	phosphoesterase, PA-phosphatase related
HA039_RS31300	COG1940	carbohydrate kinase activity
HA039_RS31310	COG0673	inositol 2-dehydrogenase activity
HA039_RS31320	COG4948	Mandelate Racemase Muconate Lactonizing
HA039_RS31325	COG1414	Transcriptional regulator
HA039_RS31335	COG1175	transmembrane transport
HA039_RS31340	COG0395	ABC-type sugar transport system, permease component
HA039_RS31345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HA039_RS31370	COG0584	glycerophosphoryl diester phosphodiesterase
HA039_RS31400	COG0204	Acyl-transferase
HA039_RS31425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HA039_RS31435	COG0515	serine threonine protein kinase
HA039_RS31435	COG2815	serine threonine protein kinase
HA039_RS31460	COG1660	Displays ATPase and GTPase activities
HA039_RS31470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA039_RS31475	COG0445	tRNA wobble uridine modification
HA039_RS31495	COG4585	Histidine kinase
HA039_RS31500	COG2197	response regulator
HA039_RS31515	COG2223	nitrite transmembrane transporter activity
HA039_RS31520	COG1940	carbohydrate kinase activity
HA039_RS31560	COG1349	DNA-binding transcription factor activity
HA039_RS31570	COG0464	growth
HA039_RS31585	COG4251	negative regulation of phosphorylation
HA039_RS31595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HA039_RS31620	COG2267	carboxylic ester hydrolase activity
HA039_RS31630	COG0463	Glycosyl transferase, family 2
HA039_RS31635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HA039_RS31670	COG0640	Transcriptional regulator
HA039_RS31695	COG0596	Alpha beta hydrolase
HA039_RS31710	COG0667	Aldo Keto reductase
HA039_RS31720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HA039_RS31730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HA039_RS31745	COG1404	Belongs to the peptidase S8 family
HA039_RS31750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HA039_RS31755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HA039_RS31780	COG0181	hydroxymethylbilane synthase activity
HA039_RS31825	COG1316	TRANSCRIPTIONal
HA039_RS31850	COG0745	RESPONSE REGULATOR receiver
HA039_RS31870	COG0598	Magnesium transport protein CorA
HA039_RS31930	COG4221	oxidoreductase activity
HA039_RS31945	COG0412	Dienelactone hydrolase
HA039_RS31985	COG0477	Major facilitator Superfamily
HA039_RS32000	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS32005	COG1129	ABC transporter
HA039_RS32010	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA039_RS32015	COG1609	Transcriptional regulator
HA039_RS32025	COG4941	Belongs to the sigma-70 factor family
HA039_RS32090	COG0475	glutathione-regulated potassium exporter activity
HA039_RS32100	COG0702	epimerase
HA039_RS32110	COG1461	Dihydroxyacetone kinase
HA039_RS32115	COG2376	Dihydroxyacetone kinase
HA039_RS32150	COG2890	protein-(glutamine-N5) methyltransferase activity
HA039_RS32175	COG2208	phosphoserine phosphatase activity
HA039_RS32175	COG2770	Histidine kinase
HA039_RS32190	COG1191	sigma factor activity
HA039_RS32225	COG3903	Transcriptional regulator
HA039_RS32225	COG3629	intracellular signal transduction
HA039_RS32245	COG1051	belongs to the nudix hydrolase family
HA039_RS32250	COG2409	Drug exporters of the RND superfamily
HA039_RS32255	COG0456	acetyltransferase
HA039_RS32260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA039_RS32265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS32290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS32295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS32300	COG4214	carbohydrate transport
HA039_RS32310	COG4213	ABC transporter substrate-binding protein
HA039_RS32325	COG0477	Major facilitator Superfamily
HA039_RS32350	COG1802	Transcriptional regulator
HA039_RS32365	COG0436	Aminotransferase
HA039_RS32380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HA039_RS32390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS32395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA039_RS32420	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HA039_RS32435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HA039_RS32445	COG0546	phosphoglycolate phosphatase activity
HA039_RS32470	COG0243	molybdopterin cofactor binding
HA039_RS32470	COG3383	formate dehydrogenase (NAD+) activity
HA039_RS32475	COG0437	4 iron, 4 sulfur cluster binding
HA039_RS32515	COG1007	ATP synthesis coupled electron transport
HA039_RS32525	COG2326	polyphosphate kinase activity
HA039_RS32560	COG4948	Mandelate Racemase Muconate Lactonizing
HA039_RS32580	COG2813	Specifically methylates the guanine in position
HA039_RS32600	COG3585	molybdate ion transport
HA039_RS32615	COG0583	DNA-binding transcription factor activity
HA039_RS32630	COG1793	dna ligase
HA039_RS32635	COG0515	serine threonine protein kinase
HA039_RS32645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HA039_RS32650	COG0387	Pfam Sodium calcium exchanger
HA039_RS32660	COG2267	carboxylic ester hydrolase activity
HA039_RS32715	COG0596	Alpha beta hydrolase
HA039_RS32720	COG0583	DNA-binding transcription factor activity
HA039_RS32760	COG2356	endonuclease I
HA039_RS32770	COG3469	chitinase activity
HA039_RS32815	COG1674	ftsk spoiiie
HA039_RS32840	COG3629	intracellular signal transduction
HA039_RS32840	COG3903	Transcriptional regulator
HA039_RS32860	COG0515	serine threonine protein kinase
HA039_RS32860	COG2815	serine threonine protein kinase
HA039_RS32885	COG0277	FAD linked oxidase domain protein
HA039_RS32910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA039_RS32915	COG0765	amino acid transport
HA039_RS32970	COG3387	PFAM Glycoside hydrolase 15-related
HA039_RS32985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HA039_RS32985	COG2755	lipolytic protein G-D-S-L family
HA039_RS33015	COG0242	peptide deformylase activity
HA039_RS33020	COG2234	aminopeptidase activity
HA039_RS33065	COG0667	Aldo Keto reductase
HA039_RS33105	COG0586	Pfam SNARE associated Golgi protein
HA039_RS33130	COG1252	NADH dehydrogenase
HA039_RS33135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HA039_RS33145	COG3619	membrane
HA039_RS33185	COG0488	(ABC) transporter
HA039_RS33245	COG1175	transmembrane transport
HA039_RS33250	COG3833	ABC-type maltose transport systems, permease component
HA039_RS33255	COG1472	Belongs to the glycosyl hydrolase 3 family
HA039_RS33265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HA039_RS33280	COG3896	Chloramphenicol phosphotransferase-like protein
HA039_RS33305	COG0183	Belongs to the thiolase family
HA039_RS33310	COG3396	Phenylacetate-CoA oxygenase
HA039_RS33315	COG3460	Phenylacetate-CoA oxygenase
HA039_RS33320	COG3396	Phenylacetate-CoA oxygenase
HA039_RS33325	COG2151	metal-sulfur cluster biosynthetic enzyme
HA039_RS33330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HA039_RS33345	COG1012	belongs to the aldehyde dehydrogenase family
HA039_RS33355	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HA039_RS33360	COG1309	transcriptional regulator
HA039_RS33365	COG2409	Drug exporters of the RND superfamily
HA039_RS33370	COG0667	Aldo Keto reductase
HA039_RS33395	COG1028	Short-chain dehydrogenase reductase Sdr
HA039_RS33405	COG2814	Major facilitator Superfamily
HA039_RS33430	COG2197	response regulator
HA039_RS33435	COG4585	Histidine kinase
HA039_RS33475	COG4249	Peptidase C14 caspase catalytic subunit p20
HA039_RS33475	COG2319	Wd-40 repeat