locus-tag	class	description
LZ559_RS00035	COG0477	Major facilitator Superfamily
LZ559_RS00045	COG3693	PFAM glycoside hydrolase, family 10
LZ559_RS00045	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ559_RS00045	COG2382	esterase
LZ559_RS00080	COG0069	glutamate synthase activity
LZ559_RS00120	COG2197	response regulator
LZ559_RS00125	COG2188	Transcriptional regulator
LZ559_RS00145	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LZ559_RS00150	COG0626	cystathionine gamma-synthase activity
LZ559_RS00155	COG3457	Alanine racemase
LZ559_RS00160	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LZ559_RS00190	COG0300	oxidoreductase activity
LZ559_RS00210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LZ559_RS00240	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LZ559_RS00260	COG0142	geranyltranstransferase activity
LZ559_RS00280	COG2208	phosphoserine phosphatase activity
LZ559_RS00280	COG2770	Histidine kinase
LZ559_RS00325	COG2267	carboxylic ester hydrolase activity
LZ559_RS00340	COG3795	YCII-related domain
LZ559_RS00345	COG4941	Belongs to the sigma-70 factor family
LZ559_RS00360	COG5297	Belongs to the glycosyl hydrolase family 6
LZ559_RS00375	COG0477	Major facilitator Superfamily
LZ559_RS00395	COG0477	Major facilitator Superfamily
LZ559_RS00405	COG1846	Transcriptional regulator
LZ559_RS00410	COG1764	response to oxidative stress
LZ559_RS00460	COG1309	transcriptional regulator
LZ559_RS00465	COG0277	FAD linked oxidase domain protein
LZ559_RS00475	COG1064	alcohol dehydrogenase
LZ559_RS00485	COG2226	methyltransferase
LZ559_RS00495	COG0702	epimerase
LZ559_RS00525	COG0583	DNA-binding transcription factor activity
LZ559_RS00540	COG0642	Histidine kinase
LZ559_RS00555	COG2318	DinB family
LZ559_RS00565	COG0366	Alpha amylase catalytic
LZ559_RS00570	COG0395	ABC-type sugar transport system, permease component
LZ559_RS00575	COG1175	transmembrane transport
LZ559_RS00580	COG1653	transport
LZ559_RS00620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ559_RS00625	COG0596	Alpha beta hydrolase
LZ559_RS00640	COG1349	DNA-binding transcription factor activity
LZ559_RS00645	COG1105	Belongs to the carbohydrate kinase PfkB family
LZ559_RS00655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LZ559_RS00710	COG2318	DinB family
LZ559_RS00740	COG0254	rRNA binding
LZ559_RS00745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LZ559_RS00775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS00785	COG0300	oxidoreductase activity
LZ559_RS00800	COG1309	transcriptional regulator
LZ559_RS00830	COG1024	Enoyl-CoA hydratase
LZ559_RS00850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS00855	COG0765	amino acid transport
LZ559_RS00875	COG2366	antibiotic biosynthetic process
LZ559_RS00885	COG2070	2-Nitropropane dioxygenase
LZ559_RS00905	COG0515	serine threonine protein kinase
LZ559_RS00925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LZ559_RS00930	COG0517	IMP dehydrogenase activity
LZ559_RS00930	COG0516	GMP reductase activity
LZ559_RS00945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LZ559_RS00950	COG0589	response to stress
LZ559_RS00955	COG4109	DRTGG domain
LZ559_RS00975	COG1063	alcohol dehydrogenase
LZ559_RS00980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LZ559_RS00985	COG0517	IMP dehydrogenase activity
LZ559_RS00995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LZ559_RS01005	COG0574	Belongs to the PEP-utilizing enzyme family
LZ559_RS01005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LZ559_RS01035	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS01040	COG2813	Specifically methylates the guanine in position
LZ559_RS01055	COG2356	endonuclease I
LZ559_RS01060	COG2066	Belongs to the glutaminase family
LZ559_RS01060	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LZ559_RS01080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZ559_RS01085	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LZ559_RS01090	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS01100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LZ559_RS01105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LZ559_RS01110	COG2080	2 iron, 2 sulfur cluster binding
LZ559_RS01165	COG2365	Tyrosine phosphatase family
LZ559_RS01190	COG1120	ATPase activity
LZ559_RS01195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LZ559_RS01205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS01215	COG0477	Major facilitator Superfamily
LZ559_RS01220	COG2382	esterase
LZ559_RS01225	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS01235	COG1169	isochorismate synthase
LZ559_RS01240	COG1021	2,3-dihydroxybenzoate-AMP ligase
LZ559_RS01245	COG1535	isochorismatase
LZ559_RS01245	COG3433	isochorismatase activity
LZ559_RS01250	COG1535	isochorismatase
LZ559_RS01250	COG3433	isochorismatase activity
LZ559_RS01290	COG1470	cell adhesion involved in biofilm formation
LZ559_RS01305	COG0148	phosphopyruvate hydratase activity
LZ559_RS01315	COG2382	esterase
LZ559_RS01320	COG1132	(ABC) transporter
LZ559_RS01330	COG1132	(ABC) transporter
LZ559_RS01335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LZ559_RS01340	COG1120	ATPase activity
LZ559_RS01345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS01350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS01355	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LZ559_RS01370	COG5002	protein histidine kinase activity
LZ559_RS01375	COG0745	RESPONSE REGULATOR receiver
LZ559_RS01415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZ559_RS01420	COG0587	DNA-directed DNA polymerase activity
LZ559_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS01495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS01525	COG0596	Alpha beta hydrolase
LZ559_RS01540	COG2376	Dihydroxyacetone kinase
LZ559_RS01545	COG1461	Dihydroxyacetone kinase
LZ559_RS01560	COG0488	(ABC) transporter
LZ559_RS01590	COG1191	sigma factor activity
LZ559_RS01595	COG1309	transcriptional regulator
LZ559_RS01600	COG3246	L-lysine catabolic process to acetate
LZ559_RS01605	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ559_RS01620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZ559_RS01625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LZ559_RS01655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ559_RS01700	COG1295	ribonuclease BN
LZ559_RS01700	COG1959	2 iron, 2 sulfur cluster binding
LZ559_RS01735	COG2837	iron assimilation
LZ559_RS01740	COG1120	ATPase activity
LZ559_RS01745	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS01750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS01785	COG1609	Transcriptional regulator
LZ559_RS01790	COG1172	Belongs to the binding-protein-dependent transport system permease family
LZ559_RS01800	COG1129	ABC transporter
LZ559_RS01805	COG1879	ABC-type sugar transport system periplasmic component
LZ559_RS01835	COG0842	Transport permease protein
LZ559_RS01835	COG1131	(ABC) transporter
LZ559_RS01835	COG1716	ATPase activity
LZ559_RS01845	COG0515	serine threonine protein kinase
LZ559_RS01845	COG2815	serine threonine protein kinase
LZ559_RS01885	COG0328	RNA-DNA hybrid ribonuclease activity
LZ559_RS01890	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS01895	COG1132	(ABC) transporter
LZ559_RS01905	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LZ559_RS02005	COG0395	ABC-type sugar transport system, permease component
LZ559_RS02070	COG1215	transferase activity, transferring glycosyl groups
LZ559_RS02090	COG0464	growth
LZ559_RS02100	COG1349	DNA-binding transcription factor activity
LZ559_RS02115	COG0702	epimerase
LZ559_RS02145	COG1940	carbohydrate kinase activity
LZ559_RS02150	COG2223	nitrite transmembrane transporter activity
LZ559_RS02180	COG0445	tRNA wobble uridine modification
LZ559_RS02195	COG1660	Displays ATPase and GTPase activities
LZ559_RS02215	COG1940	carbohydrate kinase activity
LZ559_RS02245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LZ559_RS02290	COG0584	glycerophosphoryl diester phosphodiesterase
LZ559_RS02315	COG0671	phosphoesterase, PA-phosphatase related
LZ559_RS02365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LZ559_RS02380	COG2706	6-phosphogluconolactonase activity
LZ559_RS02400	COG2815	serine threonine protein kinase
LZ559_RS02400	COG0515	serine threonine protein kinase
LZ559_RS02405	COG0667	Aldo Keto reductase
LZ559_RS02440	COG1253	flavin adenine dinucleotide binding
LZ559_RS02475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LZ559_RS02480	COG0531	amino acid
LZ559_RS02490	COG0174	glutamine synthetase
LZ559_RS02495	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS02530	COG4981	capsule polysaccharide biosynthetic process
LZ559_RS02550	COG2835	tetraacyldisaccharide 4'-kinase activity
LZ559_RS02560	COG1802	Transcriptional regulator
LZ559_RS02565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LZ559_RS02570	COG0402	S-adenosylhomocysteine deaminase activity
LZ559_RS02585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ559_RS02585	COG0515	serine threonine protein kinase
LZ559_RS02610	COG0542	response to heat
LZ559_RS02670	COG1191	sigma factor activity
LZ559_RS02690	COG2890	protein-(glutamine-N5) methyltransferase activity
LZ559_RS02715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LZ559_RS02720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LZ559_RS02725	COG2080	2 iron, 2 sulfur cluster binding
LZ559_RS02745	COG2986	histidine ammonia-lyase
LZ559_RS02750	COG1125	glycine betaine transport
LZ559_RS02750	COG0517	IMP dehydrogenase activity
LZ559_RS02755	COG1174	glycine betaine transport
LZ559_RS02770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LZ559_RS02790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LZ559_RS02805	COG4592	Periplasmic binding protein
LZ559_RS02850	COG4214	carbohydrate transport
LZ559_RS02855	COG1129	ABC transporter
LZ559_RS02865	COG1609	Transcriptional regulator
LZ559_RS02875	COG2160	L-arabinose isomerase activity
LZ559_RS02885	COG1891	lyase activity
LZ559_RS02900	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LZ559_RS02925	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LZ559_RS02940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LZ559_RS02945	COG0385	Bile acid
LZ559_RS02965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LZ559_RS02985	COG1309	transcriptional regulator
LZ559_RS03045	COG2197	response regulator
LZ559_RS03065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LZ559_RS03075	COG0798	PFAM Bile acid sodium symporter
LZ559_RS03085	COG1247	-acetyltransferase
LZ559_RS03090	COG0640	Transcriptional regulator
LZ559_RS03125	COG1335	isochorismatase
LZ559_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS03190	COG0142	geranyltranstransferase activity
LZ559_RS03210	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LZ559_RS03230	COG1191	sigma factor activity
LZ559_RS03260	COG1126	abc transporter atp-binding protein
LZ559_RS03325	COG1131	(ABC) transporter
LZ559_RS03365	COG1959	2 iron, 2 sulfur cluster binding
LZ559_RS03385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LZ559_RS03400	COG1309	transcriptional regulator
LZ559_RS03405	COG0596	Alpha beta hydrolase
LZ559_RS03425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LZ559_RS03430	COG1116	anion transmembrane transporter activity
LZ559_RS03440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS03450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LZ559_RS03460	COG1132	(ABC) transporter
LZ559_RS03465	COG1846	Transcriptional regulator
LZ559_RS03470	COG0277	FAD linked oxidase domain protein
LZ559_RS03480	COG1132	(ABC) transporter
LZ559_RS03485	COG1132	(ABC) transporter
LZ559_RS03500	COG1252	NADH dehydrogenase
LZ559_RS03505	COG1793	dna ligase
LZ559_RS03520	COG1946	Acyl-CoA thioesterase
LZ559_RS03550	COG0386	Belongs to the glutathione peroxidase family
LZ559_RS03555	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS03565	COG0242	peptide deformylase activity
LZ559_RS03575	COG3442	glutamine amidotransferase
LZ559_RS03580	COG0205	6-phosphofructokinase activity
LZ559_RS03595	COG0204	Acyl-transferase
LZ559_RS03610	COG0829	nickel cation binding
LZ559_RS03615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LZ559_RS03625	COG0804	urea catabolic process
LZ559_RS03630	COG0832	Belongs to the urease beta subunit family
LZ559_RS03635	COG0831	urea catabolic process
LZ559_RS03640	COG1309	transcriptional regulator
LZ559_RS03655	COG0740	serine-type endopeptidase activity
LZ559_RS03670	COG1280	lysine exporter protein (LysE YggA)
LZ559_RS03675	COG0583	DNA-binding transcription factor activity
LZ559_RS03695	COG0156	8-amino-7-oxononanoate synthase activity
LZ559_RS03700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LZ559_RS03705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LZ559_RS03710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LZ559_RS03715	COG2226	methyltransferase
LZ559_RS03745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LZ559_RS03755	COG1940	carbohydrate kinase activity
LZ559_RS03760	COG2188	Transcriptional regulator
LZ559_RS03765	COG1595	DNA-templated transcription, initiation
LZ559_RS03805	COG0626	cystathionine gamma-synthase activity
LZ559_RS03830	COG1522	sequence-specific DNA binding
LZ559_RS03835	COG0419	ATPase involved in DNA repair
LZ559_RS03840	COG0420	3'-5' exonuclease activity
LZ559_RS03845	COG1739	Uncharacterized protein family UPF0029
LZ559_RS03850	COG1832	CoA-binding protein
LZ559_RS03855	COG2746	aminoglycoside 3-N-acetyltransferase activity
LZ559_RS03895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LZ559_RS03915	COG1968	undecaprenyl-diphosphatase activity
LZ559_RS03930	COG0243	molybdopterin cofactor binding
LZ559_RS03935	COG2226	methyltransferase
LZ559_RS03940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LZ559_RS03980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LZ559_RS03990	COG2318	DinB family
LZ559_RS04005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LZ559_RS04080	COG0583	DNA-binding transcription factor activity
LZ559_RS04085	COG0697	spore germination
LZ559_RS04125	COG1695	Transcriptional regulator
LZ559_RS04220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LZ559_RS04220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LZ559_RS04230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZ559_RS04250	COG1716	ATPase activity
LZ559_RS04270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LZ559_RS04300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LZ559_RS04310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LZ559_RS04325	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LZ559_RS04345	COG2732	(Barnase) inhibitor
LZ559_RS04360	COG2018	Roadblock/LC7 domain
LZ559_RS04425	COG2364	Membrane
LZ559_RS04435	COG2270	Major facilitator Superfamily
LZ559_RS04450	COG1216	Glycosyl transferase, family 2
LZ559_RS04470	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS04485	COG2318	DinB family
LZ559_RS04535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LZ559_RS04540	COG0140	phosphoribosyl-ATP diphosphatase activity
LZ559_RS04545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LZ559_RS04550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LZ559_RS04550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LZ559_RS04555	COG3201	nicotinamide mononucleotide transporter
LZ559_RS04575	COG0702	epimerase
LZ559_RS04580	COG1940	carbohydrate kinase activity
LZ559_RS04585	COG0738	Major facilitator superfamily
LZ559_RS04590	COG2233	PERMEase
LZ559_RS04625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZ559_RS04635	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS04650	COG2390	Transcriptional regulator
LZ559_RS04655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LZ559_RS04665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LZ559_RS04675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LZ559_RS04680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LZ559_RS04690	COG1758	RNA polymerase activity
LZ559_RS04705	COG0284	orotidine-5'-phosphate decarboxylase activity
LZ559_RS04710	COG0167	dihydroorotate dehydrogenase activity
LZ559_RS04715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LZ559_RS04720	COG0505	Belongs to the CarA family
LZ559_RS04730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LZ559_RS04735	COG0540	Belongs to the ATCase OTCase family
LZ559_RS04740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LZ559_RS04750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LZ559_RS04755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LZ559_RS04760	COG0006	proline dipeptidase activity
LZ559_RS04770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LZ559_RS04775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LZ559_RS04780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LZ559_RS04785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LZ559_RS04795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LZ559_RS04800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LZ559_RS04820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LZ559_RS04840	COG0124	histidyl-tRNA synthetase
LZ559_RS04855	COG1196	nuclear chromosome segregation
LZ559_RS04860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZ559_RS04865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LZ559_RS04870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LZ559_RS04875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LZ559_RS04885	COG2255	four-way junction helicase activity
LZ559_RS04890	COG0632	four-way junction helicase activity
LZ559_RS04900	COG0217	transcriptional regulatory protein
LZ559_RS04905	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LZ559_RS04910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LZ559_RS04920	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS04925	COG1560	Kdo2-lipid A biosynthetic process
LZ559_RS04930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LZ559_RS04955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LZ559_RS04970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZ559_RS05020	COG0456	acetyltransferase
LZ559_RS05020	COG0454	-acetyltransferase
LZ559_RS05030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LZ559_RS05085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LZ559_RS05085	COG1648	precorrin-2 dehydrogenase activity
LZ559_RS05090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LZ559_RS05105	COG1464	Belongs to the NlpA lipoprotein family
LZ559_RS05110	COG2011	ABC-type metal ion transport system permease component
LZ559_RS05150	COG0477	Major facilitator Superfamily
LZ559_RS05160	COG3973	AAA domain
LZ559_RS05170	COG0165	Argininosuccinate lyase
LZ559_RS05175	COG0137	argininosuccinate synthase activity
LZ559_RS05190	COG1438	arginine binding
LZ559_RS05195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZ559_RS05200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LZ559_RS05205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LZ559_RS05210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LZ559_RS05265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ559_RS05280	COG0697	spore germination
LZ559_RS05290	COG1649	PFAM Uncharacterised BCR, COG1649
LZ559_RS05305	COG0494	nUDIX hydrolase
LZ559_RS05315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ559_RS05315	COG0072	phenylalanine-tRNA ligase activity
LZ559_RS05320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LZ559_RS05325	COG5002	protein histidine kinase activity
LZ559_RS05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LZ559_RS05335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LZ559_RS05340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LZ559_RS05345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LZ559_RS05355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LZ559_RS05410	COG4175	Glycine betaine
LZ559_RS05410	COG0517	IMP dehydrogenase activity
LZ559_RS05415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LZ559_RS05460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LZ559_RS05465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LZ559_RS05500	COG0805	protein transport
LZ559_RS05505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LZ559_RS05525	COG2378	regulation of single-species biofilm formation
LZ559_RS05535	COG0545	Peptidyl-prolyl cis-trans isomerase
LZ559_RS05540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LZ559_RS05550	COG1609	Transcriptional regulator
LZ559_RS05555	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LZ559_RS05560	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LZ559_RS05575	COG4122	O-methyltransferase activity
LZ559_RS05580	COG1222	aaa ATPase
LZ559_RS05600	COG0517	IMP dehydrogenase activity
LZ559_RS05600	COG1994	Peptidase M50
LZ559_RS05610	COG2197	response regulator
LZ559_RS05615	COG4166	transmembrane transport
LZ559_RS05620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LZ559_RS05625	COG0646	methionine synthase
LZ559_RS05625	COG1410	methionine synthase
LZ559_RS05630	COG1414	Transcriptional regulator
LZ559_RS05635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LZ559_RS05640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LZ559_RS05645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LZ559_RS05650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS05665	COG0215	cysteine-tRNA ligase activity
LZ559_RS05685	COG0598	Magnesium transport protein CorA
LZ559_RS05695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS05700	COG0667	Aldo Keto reductase
LZ559_RS05730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LZ559_RS05740	COG0564	pseudouridine synthase activity
LZ559_RS05755	COG2186	Transcriptional regulator
LZ559_RS05760	COG3265	gluconokinase activity
LZ559_RS05785	COG3573	Dehydrogenase
LZ559_RS05790	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LZ559_RS05795	COG2149	membrane
LZ559_RS05810	COG4948	Mandelate Racemase Muconate Lactonizing
LZ559_RS05820	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS05825	COG4935	Belongs to the peptidase S8 family
LZ559_RS05825	COG2234	aminopeptidase activity
LZ559_RS05835	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS05845	COG3876	Protein conserved in bacteria
LZ559_RS05860	COG0789	Transcriptional regulator
LZ559_RS05880	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS05915	COG2318	DinB family
LZ559_RS05925	COG2851	Citrate transporter
LZ559_RS05930	COG0243	molybdopterin cofactor binding
LZ559_RS05935	COG1309	transcriptional regulator
LZ559_RS05940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LZ559_RS05945	COG2188	Transcriptional regulator
LZ559_RS05955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LZ559_RS05965	COG2755	lipolytic protein G-D-S-L family
LZ559_RS05975	COG1725	Transcriptional regulator
LZ559_RS05990	COG0346	lactoylglutathione lyase activity
LZ559_RS06010	COG4565	transcriptional regulatory protein
LZ559_RS06050	COG1674	ftsk spoiiie
LZ559_RS06135	COG0641	radical SAM
LZ559_RS06165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS06170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS06175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS06180	COG1126	abc transporter atp-binding protein
LZ559_RS06195	COG0765	amino acid transport
LZ559_RS06200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS06210	COG1799	cell septum assembly
LZ559_RS06215	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS06220	COG0477	Major facilitator Superfamily
LZ559_RS06225	COG0671	phosphoesterase, PA-phosphatase related
LZ559_RS06245	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS06260	COG1160	GTP binding
LZ559_RS06270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LZ559_RS06330	COG1187	pseudouridine synthase activity
LZ559_RS06335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LZ559_RS06340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LZ559_RS06355	COG0686	Belongs to the AlaDH PNT family
LZ559_RS06365	COG0494	nUDIX hydrolase
LZ559_RS06370	COG0504	CTP synthase activity
LZ559_RS06375	COG3387	PFAM Glycoside hydrolase 15-related
LZ559_RS06385	COG0789	Transcriptional regulator
LZ559_RS06400	COG0497	DNA recombination
LZ559_RS06405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LZ559_RS06430	COG0647	UMP catabolic process
LZ559_RS06465	COG2094	Belongs to the DNA glycosylase MPG family
LZ559_RS06475	COG1881	PFAM PEBP family protein
LZ559_RS06500	COG1119	ATPase activity
LZ559_RS06515	COG2197	response regulator
LZ559_RS06530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LZ559_RS06540	COG1716	ATPase activity
LZ559_RS06540	COG1131	(ABC) transporter
LZ559_RS06540	COG0842	Transport permease protein
LZ559_RS06545	COG3830	Belongs to the UPF0237 family
LZ559_RS06545	COG0560	Phosphoserine phosphatase
LZ559_RS06565	COG2186	Transcriptional regulator
LZ559_RS06575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LZ559_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS06595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LZ559_RS06600	COG2261	transglycosylase associated protein
LZ559_RS06615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LZ559_RS06620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ559_RS06655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZ559_RS06655	COG1199	ATP-dependent helicase activity
LZ559_RS06670	COG3387	PFAM Glycoside hydrolase 15-related
LZ559_RS06720	COG0488	(ABC) transporter
LZ559_RS06745	COG0235	Class ii aldolase
LZ559_RS06760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LZ559_RS06765	COG1492	cobalamin metabolic process
LZ559_RS06780	COG1797	cobyrinic acid a,c-diamide synthase activity
LZ559_RS06805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LZ559_RS06835	COG1902	pentaerythritol trinitrate reductase activity
LZ559_RS06840	COG1846	Transcriptional regulator
LZ559_RS06870	COG1414	Transcriptional regulator
LZ559_RS06885	COG4585	Histidine kinase
LZ559_RS06890	COG2197	response regulator
LZ559_RS06895	COG0768	penicillin binding
LZ559_RS06905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS06915	COG0431	NADPH-dependent FMN reductase
LZ559_RS06930	COG0583	DNA-binding transcription factor activity
LZ559_RS06945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LZ559_RS06950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ559_RS06980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LZ559_RS06990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LZ559_RS06995	COG2171	N-acyltransferase activity
LZ559_RS07010	COG3226	Transcriptional regulator
LZ559_RS07030	COG2151	metal-sulfur cluster biosynthetic enzyme
LZ559_RS07035	COG0822	iron-sulfur transferase activity
LZ559_RS07040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LZ559_RS07045	COG0396	ATPase activity
LZ559_RS07055	COG0719	Fe-S assembly protein
LZ559_RS07095	COG0109	protoheme IX farnesyltransferase activity
LZ559_RS07105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LZ559_RS07120	COG0363	glucosamine-6-phosphate deaminase activity
LZ559_RS07150	COG0166	Belongs to the GPI family
LZ559_RS07160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LZ559_RS07165	COG0149	triose-phosphate isomerase activity
LZ559_RS07170	COG0126	phosphoglycerate kinase activity
LZ559_RS07175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LZ559_RS07180	COG1481	regulation of sporulation
LZ559_RS07185	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LZ559_RS07190	COG1660	Displays ATPase and GTPase activities
LZ559_RS07195	COG0322	excinuclease ABC activity
LZ559_RS07220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LZ559_RS07250	COG0556	nucleotide-excision repair
LZ559_RS07260	COG0584	glycerophosphoryl diester phosphodiesterase
LZ559_RS07265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LZ559_RS07270	COG2814	Major facilitator Superfamily
LZ559_RS07280	COG2313	pseudouridylate synthase activity
LZ559_RS07300	COG0436	Aminotransferase
LZ559_RS07320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LZ559_RS07330	COG2226	methyltransferase
LZ559_RS07345	COG0237	dephospho-CoA kinase activity
LZ559_RS07365	COG2226	methyltransferase
LZ559_RS07370	COG1643	Atp-dependent helicase
LZ559_RS07405	COG2050	protein possibly involved in aromatic compounds catabolism
LZ559_RS07460	COG0737	Belongs to the 5'-nucleotidase family
LZ559_RS07495	COG0287	Prephenate dehydrogenase
LZ559_RS07495	COG1605	Chorismate mutase
LZ559_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS07540	COG1024	Enoyl-CoA hydratase
LZ559_RS07565	COG1278	Cold shock
LZ559_RS07570	COG0183	Belongs to the thiolase family
LZ559_RS07575	COG1309	transcriptional regulator
LZ559_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS07585	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS07590	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS07620	COG0067	glutamate synthase
LZ559_RS07620	COG0069	glutamate synthase activity
LZ559_RS07620	COG0070	glutamate synthase
LZ559_RS07650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ559_RS07655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LZ559_RS07665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LZ559_RS07675	COG0159	tryptophan synthase activity
LZ559_RS07680	COG0133	tryptophan synthase activity
LZ559_RS07690	COG0134	indole-3-glycerol-phosphate synthase activity
LZ559_RS07710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LZ559_RS07715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LZ559_RS07735	COG2508	Transcriptional regulator
LZ559_RS07750	COG0107	imidazoleglycerol-phosphate synthase activity
LZ559_RS07755	COG0251	oxidation-reduction process
LZ559_RS07760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LZ559_RS07765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LZ559_RS07775	COG0131	Imidazoleglycerol-phosphate dehydratase
LZ559_RS07780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LZ559_RS07785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LZ559_RS07825	COG1432	Conserved Protein
LZ559_RS07835	COG0587	DNA-directed DNA polymerase activity
LZ559_RS07870	COG2153	protein acetylation
LZ559_RS07880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LZ559_RS07890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LZ559_RS07895	COG3599	regulation of cell shape
LZ559_RS07905	COG1799	cell septum assembly
LZ559_RS07910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LZ559_RS07930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LZ559_RS07940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LZ559_RS07945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LZ559_RS07955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LZ559_RS07960	COG0768	penicillin binding
LZ559_RS07970	COG0275	rRNA processing
LZ559_RS07980	COG0714	Associated with various cellular activities
LZ559_RS08000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LZ559_RS08010	COG1136	(ABC) transporter
LZ559_RS08045	COG0352	thiamine-phosphate diphosphorylase activity
LZ559_RS08065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZ559_RS08065	COG2022	thiamine diphosphate biosynthetic process
LZ559_RS08075	COG2022	thiamine diphosphate biosynthetic process
LZ559_RS08080	COG2815	serine threonine protein kinase
LZ559_RS08080	COG0515	serine threonine protein kinase
LZ559_RS08085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LZ559_RS08090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LZ559_RS08095	COG2193	ferroxidase activity
LZ559_RS08105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LZ559_RS08115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LZ559_RS08120	COG2197	response regulator
LZ559_RS08150	COG1940	carbohydrate kinase activity
LZ559_RS08160	COG0003	Pfam Anion-transporting ATPase
LZ559_RS08225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LZ559_RS08230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LZ559_RS08235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LZ559_RS08240	COG0723	plastoquinol--plastocyanin reductase activity
LZ559_RS08245	COG2010	Cytochrome c
LZ559_RS08250	COG1845	cytochrome c oxidase, subunit III
LZ559_RS08260	COG1376	ErfK ybiS ycfS ynhG family protein
LZ559_RS08270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LZ559_RS08275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LZ559_RS08285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ559_RS08305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LZ559_RS08315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ559_RS08320	COG2197	response regulator
LZ559_RS08325	COG4585	Histidine kinase
LZ559_RS08350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZ559_RS08365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LZ559_RS08380	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LZ559_RS08385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LZ559_RS08390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZ559_RS08395	COG0508	dehydrogenase complex catalyzes the overall conversion of
LZ559_RS08405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LZ559_RS08425	COG1090	epimerase
LZ559_RS08440	COG0321	lipoyl(octanoyl) transferase activity
LZ559_RS08445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LZ559_RS08495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ559_RS08500	COG3896	Chloramphenicol phosphotransferase-like protein
LZ559_RS08505	COG2362	D-Aminopeptidase
LZ559_RS08525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ559_RS08530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ559_RS08555	COG0745	RESPONSE REGULATOR receiver
LZ559_RS08560	COG2409	Drug exporters of the RND superfamily
LZ559_RS08565	COG4585	Histidine kinase
LZ559_RS08570	COG2197	response regulator
LZ559_RS08640	COG0366	Alpha amylase catalytic
LZ559_RS08645	COG0395	ABC-type sugar transport system, permease component
LZ559_RS08650	COG1175	transmembrane transport
LZ559_RS08660	COG1609	Transcriptional regulator
LZ559_RS08670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LZ559_RS08680	COG2890	protein-(glutamine-N5) methyltransferase activity
LZ559_RS08685	COG2814	Major facilitator Superfamily
LZ559_RS08725	COG0174	glutamine synthetase
LZ559_RS08750	COG2132	Multicopper oxidase
LZ559_RS08755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZ559_RS08755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LZ559_RS08760	COG2814	Major facilitator Superfamily
LZ559_RS08775	COG0477	Major facilitator Superfamily
LZ559_RS08780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LZ559_RS08800	COG1994	Peptidase M50
LZ559_RS08865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS08870	COG1120	ATPase activity
LZ559_RS08890	COG1834	amidinotransferase
LZ559_RS08905	COG2814	Major facilitator Superfamily
LZ559_RS08915	COG3540	Alkaline phosphatase
LZ559_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS08930	COG0384	phenazine biosynthesis protein PhzF
LZ559_RS08965	COG2273	Hydrolase Family 16
LZ559_RS08995	COG3022	response to hydroperoxide
LZ559_RS09000	COG0800	Aldolase
LZ559_RS09020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LZ559_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS09040	COG2030	dehydratase
LZ559_RS09050	COG0183	Belongs to the thiolase family
LZ559_RS09055	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS09060	COG2814	Major facilitator Superfamily
LZ559_RS09070	COG0860	N-Acetylmuramoyl-L-alanine amidase
LZ559_RS09080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS09115	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS09120	COG1309	transcriptional regulator
LZ559_RS09190	COG3209	COG3209 Rhs family protein
LZ559_RS09235	COG3845	ABC transporter
LZ559_RS09245	COG0183	Belongs to the thiolase family
LZ559_RS09250	COG2124	cytochrome p450
LZ559_RS09400	COG1358	cellular component organization or biogenesis
LZ559_RS09445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LZ559_RS09455	COG0477	Major facilitator Superfamily
LZ559_RS09460	COG1309	transcriptional regulator
LZ559_RS09475	COG4585	Histidine kinase
LZ559_RS09480	COG2197	response regulator
LZ559_RS09495	COG0667	Aldo Keto reductase
LZ559_RS09500	COG0789	Transcriptional regulator
LZ559_RS09510	COG2205	protein histidine kinase activity
LZ559_RS09515	COG0745	RESPONSE REGULATOR receiver
LZ559_RS09525	COG1929	Belongs to the glycerate kinase type-1 family
LZ559_RS09560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ559_RS09635	COG1674	ftsk spoiiie
LZ559_RS09640	COG1404	Belongs to the peptidase S8 family
LZ559_RS09660	COG1741	Belongs to the pirin family
LZ559_RS09675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ559_RS09680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ559_RS09685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ559_RS09705	COG1280	lysine exporter protein (LysE YggA)
LZ559_RS09715	COG1764	response to oxidative stress
LZ559_RS09720	COG2130	NADP-dependent
LZ559_RS09750	COG1522	sequence-specific DNA binding
LZ559_RS09770	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS09775	COG0825	malonyl-CoA metabolic process
LZ559_RS09775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LZ559_RS09780	COG1309	transcriptional regulator
LZ559_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS09790	COG0477	Major facilitator Superfamily
LZ559_RS09815	COG2197	response regulator
LZ559_RS09820	COG0475	glutathione-regulated potassium exporter activity
LZ559_RS09825	COG0367	asparagine synthase
LZ559_RS09840	COG1132	(ABC) transporter
LZ559_RS09845	COG2375	cellular response to nickel ion
LZ559_RS09845	COG1132	(ABC) transporter
LZ559_RS09855	COG3433	isochorismatase activity
LZ559_RS09855	COG2226	methyltransferase
LZ559_RS09855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS09860	COG2226	methyltransferase
LZ559_RS09860	COG3433	isochorismatase activity
LZ559_RS09860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS09870	COG3483	tryptophan 2,3-dioxygenase activity
LZ559_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS09890	COG0436	Aminotransferase
LZ559_RS09910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS09925	COG0657	acetylesterase activity
LZ559_RS09935	COG2124	cytochrome p450
LZ559_RS09950	COG0142	geranyltranstransferase activity
LZ559_RS09980	COG3425	synthase
LZ559_RS10010	COG2070	2-Nitropropane dioxygenase
LZ559_RS10015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZ559_RS10035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LZ559_RS10050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS10060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ559_RS10065	COG0154	amidase activity
LZ559_RS10085	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS10110	COG2175	clavaminate synthase activity
LZ559_RS10120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS10145	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LZ559_RS10185	COG1070	Carbohydrate kinase
LZ559_RS10200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LZ559_RS10205	COG0358	DNA primase activity
LZ559_RS10215	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LZ559_RS10225	COG2949	membrane
LZ559_RS10270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LZ559_RS10270	COG2146	nitrite reductase [NAD(P)H] activity
LZ559_RS10275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LZ559_RS10275	COG2146	nitrite reductase [NAD(P)H] activity
LZ559_RS10295	COG0574	Belongs to the PEP-utilizing enzyme family
LZ559_RS10295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LZ559_RS10330	COG0477	Major facilitator Superfamily
LZ559_RS10350	COG2066	Belongs to the glutaminase family
LZ559_RS10365	COG0574	Belongs to the PEP-utilizing enzyme family
LZ559_RS10365	COG3848	Pyruvate phosphate dikinase
LZ559_RS10455	COG4221	oxidoreductase activity
LZ559_RS10480	COG0423	glycine-tRNA ligase activity
LZ559_RS10490	COG1121	(ABC) transporter
LZ559_RS10495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LZ559_RS10505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LZ559_RS10510	COG1381	Involved in DNA repair and RecF pathway recombination
LZ559_RS10520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LZ559_RS10535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LZ559_RS10550	COG2315	Protein conserved in bacteria
LZ559_RS10560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LZ559_RS10570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ559_RS10580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LZ559_RS10585	COG1234	tRNA 3'-trailer cleavage
LZ559_RS10590	COG0537	adenosine 5'-monophosphoramidase activity
LZ559_RS10605	COG0484	heat shock protein binding
LZ559_RS10610	COG1420	regulation of RNA biosynthetic process
LZ559_RS10650	COG1022	Amp-dependent synthetase and ligase
LZ559_RS10655	COG0481	GTPase activity
LZ559_RS10660	COG0268	Binds directly to 16S ribosomal RNA
LZ559_RS10675	COG2353	YceI-like domain
LZ559_RS10685	COG1234	tRNA 3'-trailer cleavage
LZ559_RS10690	COG1555	photosystem II stabilization
LZ559_RS10695	COG1307	EDD domain protein, DegV family
LZ559_RS10705	COG0495	leucyl-tRNA aminoacylation
LZ559_RS10715	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LZ559_RS10735	COG0588	phosphoglycerate mutase activity
LZ559_RS10740	COG0799	negative regulation of ribosome biogenesis
LZ559_RS10750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LZ559_RS10765	COG0501	Belongs to the peptidase M48B family
LZ559_RS10780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LZ559_RS10790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LZ559_RS10795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LZ559_RS10815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LZ559_RS10820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LZ559_RS10825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LZ559_RS10850	COG0673	inositol 2-dehydrogenase activity
LZ559_RS10855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LZ559_RS10860	COG1530	ribonuclease E activity
LZ559_RS10885	COG0772	Belongs to the SEDS family
LZ559_RS10890	COG0768	penicillin binding
LZ559_RS10905	COG1077	Cell shape determining protein MreB Mrl
LZ559_RS10910	COG0105	UTP biosynthetic process
LZ559_RS10920	COG0285	dihydrofolate synthase activity
LZ559_RS10925	COG0525	valine-tRNA ligase activity
LZ559_RS10935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LZ559_RS10940	COG0740	serine-type endopeptidase activity
LZ559_RS10945	COG0740	serine-type endopeptidase activity
LZ559_RS10950	COG0544	peptidyl-prolyl cis-trans isomerase activity
LZ559_RS10970	COG3594	Acyltransferase
LZ559_RS10980	COG0475	glutathione-regulated potassium exporter activity
LZ559_RS11000	COG1113	amino acid transport
LZ559_RS11010	COG1268	BioY protein
LZ559_RS11015	COG1113	amino acid transport
LZ559_RS11020	COG1113	amino acid transport
LZ559_RS11025	COG0584	glycerophosphoryl diester phosphodiesterase
LZ559_RS11030	COG0783	Belongs to the Dps family
LZ559_RS11040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LZ559_RS11045	COG0640	Transcriptional regulator
LZ559_RS11060	COG0110	maltose O-acetyltransferase activity
LZ559_RS11110	COG2252	PERMEase
LZ559_RS11125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LZ559_RS11150	COG2337	Toxic component of a toxin-antitoxin (TA) module
LZ559_RS11175	COG4266	Belongs to the allantoicase family
LZ559_RS11200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ559_RS11200	COG3291	Pkd domain containing protein
LZ559_RS11210	COG0668	transmembrane transport
LZ559_RS11215	COG1940	carbohydrate kinase activity
LZ559_RS11225	COG1175	transmembrane transport
LZ559_RS11230	COG0395	ABC-type sugar transport system, permease component
LZ559_RS11235	COG1486	melibiose metabolic process
LZ559_RS11250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS11280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LZ559_RS11285	COG2346	COG2346, Truncated hemoglobins
LZ559_RS11300	COG0577	efflux transmembrane transporter activity
LZ559_RS11300	COG1136	(ABC) transporter
LZ559_RS11325	COG0629	single-stranded DNA binding
LZ559_RS11355	COG2197	response regulator
LZ559_RS11360	COG4585	Histidine kinase
LZ559_RS11395	COG1131	(ABC) transporter
LZ559_RS11420	COG4585	Histidine kinase
LZ559_RS11435	COG3962	Belongs to the TPP enzyme family
LZ559_RS11440	COG3718	enzyme involved in inositol metabolism
LZ559_RS11450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ559_RS11460	COG2318	DinB family
LZ559_RS11475	COG2409	Drug exporters of the RND superfamily
LZ559_RS11500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LZ559_RS11510	COG0477	Major facilitator Superfamily
LZ559_RS11520	COG0596	Alpha beta hydrolase
LZ559_RS11560	COG2318	DinB family
LZ559_RS11575	COG0673	inositol 2-dehydrogenase activity
LZ559_RS11580	COG1609	Transcriptional regulator
LZ559_RS11605	COG0515	serine threonine protein kinase
LZ559_RS11645	COG1404	Belongs to the peptidase S8 family
LZ559_RS11660	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ559_RS11690	COG0028	Belongs to the TPP enzyme family
LZ559_RS11700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ559_RS11775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LZ559_RS11795	COG1946	Acyl-CoA thioesterase
LZ559_RS11830	COG1309	transcriptional regulator
LZ559_RS11835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LZ559_RS11850	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS11860	COG1733	regulation of RNA biosynthetic process
LZ559_RS11870	COG2375	cellular response to nickel ion
LZ559_RS11875	COG0076	glutamate decarboxylase activity
LZ559_RS11880	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LZ559_RS11905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZ559_RS11910	COG0589	response to stress
LZ559_RS11915	COG4977	sequence-specific DNA binding
LZ559_RS11940	COG0395	ABC-type sugar transport system, permease component
LZ559_RS11955	COG2985	domain, Protein
LZ559_RS12045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS12060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS12065	COG0765	amino acid transport
LZ559_RS12070	COG0765	amino acid transport
LZ559_RS12075	COG1126	abc transporter atp-binding protein
LZ559_RS12090	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS12095	COG3397	chitin binding
LZ559_RS12190	COG2188	Transcriptional regulator
LZ559_RS12200	COG1940	carbohydrate kinase activity
LZ559_RS12205	COG0673	inositol 2-dehydrogenase activity
LZ559_RS12210	COG4702	Belongs to the UPF0303 family
LZ559_RS12220	COG0706	membrane insertase activity
LZ559_RS12220	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
LZ559_RS12230	COG3764	Sortase (surface protein transpeptidase)
LZ559_RS12265	COG3655	Transcriptional regulator
LZ559_RS12300	COG3135	benzoate transporter
LZ559_RS12305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ559_RS12320	COG2175	clavaminate synthase activity
LZ559_RS12335	COG2733	membrane
LZ559_RS12365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LZ559_RS12390	COG0477	Major facilitator Superfamily
LZ559_RS12410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LZ559_RS12420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LZ559_RS12425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LZ559_RS12430	COG1263	PTS System
LZ559_RS12435	COG1263	PTS System
LZ559_RS12470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS12485	COG1113	amino acid transport
LZ559_RS12495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LZ559_RS12505	COG1335	isochorismatase
LZ559_RS12515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS12545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LZ559_RS12550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LZ559_RS12560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LZ559_RS12575	COG2192	nodulation
LZ559_RS12580	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LZ559_RS12590	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LZ559_RS12630	COG0277	FAD linked oxidase domain protein
LZ559_RS12640	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LZ559_RS12650	COG1174	glycine betaine transport
LZ559_RS12660	COG1174	glycine betaine transport
LZ559_RS12665	COG1732	Glycine betaine
LZ559_RS12685	COG3480	Lon protease (S16) C-terminal proteolytic domain
LZ559_RS12700	COG3654	unkown
LZ559_RS12710	COG2814	Major facilitator Superfamily
LZ559_RS12770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ559_RS12775	COG0395	ABC-type sugar transport system, permease component
LZ559_RS12795	COG1678	Uncharacterized ACR, COG1678
LZ559_RS12800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LZ559_RS12815	COG0776	regulation of translation
LZ559_RS12825	COG3973	AAA domain
LZ559_RS12825	COG3973	AAA domain
LZ559_RS12860	COG2223	nitrite transmembrane transporter activity
LZ559_RS12880	COG0583	DNA-binding transcription factor activity
LZ559_RS12895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LZ559_RS12900	COG0793	Belongs to the peptidase S41A family
LZ559_RS12905	COG2177	Part of the ABC transporter FtsEX involved in
LZ559_RS12910	COG2884	Cell division ATP-binding protein ftsE
LZ559_RS12925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LZ559_RS12930	COG0515	serine threonine protein kinase
LZ559_RS12935	COG0515	serine threonine protein kinase
LZ559_RS12945	COG1653	transport
LZ559_RS12950	COG1175	transmembrane transport
LZ559_RS12955	COG0395	ABC-type sugar transport system, permease component
LZ559_RS12960	COG1216	Glycosyl transferase, family 2
LZ559_RS12960	COG1442	glycosyl transferase family 8
LZ559_RS12965	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS12970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LZ559_RS12975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LZ559_RS12990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LZ559_RS12995	COG1216	Glycosyl transferase, family 2
LZ559_RS13005	COG1309	transcriptional regulator
LZ559_RS13015	COG1134	teichoic acid transport
LZ559_RS13020	COG2902	Dehydrogenase
LZ559_RS13045	COG0653	protein targeting
LZ559_RS13060	COG2197	response regulator
LZ559_RS13065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LZ559_RS13075	COG0823	Involved in the tonB-independent uptake of proteins
LZ559_RS13080	COG5002	protein histidine kinase activity
LZ559_RS13080	COG5000	phosphorelay sensor kinase activity
LZ559_RS13085	COG0745	RESPONSE REGULATOR receiver
LZ559_RS13090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LZ559_RS13110	COG0714	Associated with various cellular activities
LZ559_RS13150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LZ559_RS13170	COG2835	tetraacyldisaccharide 4'-kinase activity
LZ559_RS13175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LZ559_RS13210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LZ559_RS13215	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LZ559_RS13215	COG0778	Nitroreductase
LZ559_RS13225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LZ559_RS13240	COG1316	TRANSCRIPTIONal
LZ559_RS13245	COG1316	TRANSCRIPTIONal
LZ559_RS13260	COG1316	TRANSCRIPTIONal
LZ559_RS13270	COG1316	TRANSCRIPTIONal
LZ559_RS13335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LZ559_RS13370	COG2205	protein histidine kinase activity
LZ559_RS13375	COG0745	RESPONSE REGULATOR receiver
LZ559_RS13380	COG3104	oligopeptide transport
LZ559_RS13410	COG1366	Belongs to the anti-sigma-factor antagonist family
LZ559_RS13415	COG1191	sigma factor activity
LZ559_RS13420	COG1228	amidohydrolase
LZ559_RS13435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LZ559_RS13440	COG0531	amino acid
LZ559_RS13480	COG2755	lipolytic protein G-D-S-L family
LZ559_RS13485	COG0183	Belongs to the thiolase family
LZ559_RS13510	COG1136	(ABC) transporter
LZ559_RS13510	COG0577	efflux transmembrane transporter activity
LZ559_RS13515	COG1136	(ABC) transporter
LZ559_RS13515	COG0577	efflux transmembrane transporter activity
LZ559_RS13520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LZ559_RS13525	COG1252	NADH dehydrogenase
LZ559_RS13545	COG0148	phosphopyruvate hydratase activity
LZ559_RS13555	COG1652	LysM domain
LZ559_RS13575	COG0515	serine threonine protein kinase
LZ559_RS13575	COG2815	serine threonine protein kinase
LZ559_RS13645	COG0577	efflux transmembrane transporter activity
LZ559_RS13650	COG1136	(ABC) transporter
LZ559_RS13655	COG2814	Major facilitator Superfamily
LZ559_RS13670	COG0640	Transcriptional regulator
LZ559_RS13675	COG0346	lactoylglutathione lyase activity
LZ559_RS13715	COG2124	cytochrome p450
LZ559_RS13720	COG2124	cytochrome p450
LZ559_RS13750	COG4585	Histidine kinase
LZ559_RS13760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LZ559_RS13765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LZ559_RS13770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LZ559_RS13775	COG0193	aminoacyl-tRNA hydrolase activity
LZ559_RS13785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LZ559_RS13810	COG4106	trans-aconitate 2-methyltransferase activity
LZ559_RS13815	COG1846	Transcriptional regulator
LZ559_RS13820	COG2197	response regulator
LZ559_RS13830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LZ559_RS13845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ559_RS13875	COG0488	(ABC) transporter
LZ559_RS13885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LZ559_RS13890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LZ559_RS13900	COG0084	hydrolase, TatD family'
LZ559_RS13930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ559_RS13990	COG0442	prolyl-tRNA aminoacylation
LZ559_RS14000	COG1115	amino acid carrier protein
LZ559_RS14035	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LZ559_RS14040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ559_RS14065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ559_RS14070	COG1122	ATPase activity
LZ559_RS14080	COG0310	cobalt ion transport
LZ559_RS14100	COG2409	Drug exporters of the RND superfamily
LZ559_RS14110	COG4946	Tricorn protease homolog
LZ559_RS14110	COG0793	Belongs to the peptidase S41A family
LZ559_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS14135	COG2072	flavoprotein involved in K transport
LZ559_RS14145	COG0708	Exodeoxyribonuclease III
LZ559_RS14175	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LZ559_RS14190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ559_RS14195	COG0521	Mo-molybdopterin cofactor biosynthetic process
LZ559_RS14200	COG0315	cyclic pyranopterin monophosphate synthase activity
LZ559_RS14210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LZ559_RS14215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LZ559_RS14240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LZ559_RS14250	COG1970	mechanosensitive ion channel activity
LZ559_RS14270	COG0437	4 iron, 4 sulfur cluster binding
LZ559_RS14275	COG0243	molybdopterin cofactor binding
LZ559_RS14295	COG0477	Major facilitator Superfamily
LZ559_RS14310	COG3384	dioxygenase
LZ559_RS14315	COG1846	Transcriptional regulator
LZ559_RS14335	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS14355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ559_RS14355	COG3320	Male sterility
LZ559_RS14360	COG0604	alcohol dehydrogenase
LZ559_RS14360	COG3321	synthase
LZ559_RS14365	COG3321	synthase
LZ559_RS14365	COG0604	alcohol dehydrogenase
LZ559_RS14375	COG2197	response regulator
LZ559_RS14400	COG1309	transcriptional regulator
LZ559_RS14430	COG1686	Belongs to the peptidase S11 family
LZ559_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS14495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LZ559_RS14515	COG0667	Aldo Keto reductase
LZ559_RS14520	COG2226	methyltransferase
LZ559_RS14535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LZ559_RS14545	COG0477	Major facilitator Superfamily
LZ559_RS14570	COG0768	penicillin binding
LZ559_RS14640	COG4677	pectinesterase activity
LZ559_RS14645	COG3866	Pectate lyase
LZ559_RS14650	COG2755	lipolytic protein G-D-S-L family
LZ559_RS14655	COG1653	transport
LZ559_RS14675	COG0395	ABC-type sugar transport system, permease component
LZ559_RS14690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LZ559_RS14695	COG1802	Transcriptional regulator
LZ559_RS14700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ559_RS14710	COG0667	Aldo Keto reductase
LZ559_RS14755	COG3940	Belongs to the glycosyl hydrolase 43 family
LZ559_RS14765	COG1309	transcriptional regulator
LZ559_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS14800	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS14810	COG3647	Membrane
LZ559_RS14815	COG1309	transcriptional regulator
LZ559_RS14840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LZ559_RS14855	COG0163	prenyltransferase activity
LZ559_RS14865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LZ559_RS14870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LZ559_RS14880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LZ559_RS14885	COG1333	cytochrome c biogenesis protein
LZ559_RS14890	COG0785	Cytochrome C biogenesis protein
LZ559_RS14910	COG0406	alpha-ribazole phosphatase activity
LZ559_RS14915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LZ559_RS14945	COG1116	anion transmembrane transporter activity
LZ559_RS14960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LZ559_RS14970	COG1690	Belongs to the RtcB family
LZ559_RS14990	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LZ559_RS14995	COG0018	arginyl-trna synthetase
LZ559_RS15005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZ559_RS15010	COG0789	Transcriptional regulator
LZ559_RS15040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LZ559_RS15045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LZ559_RS15085	COG0113	porphobilinogen synthase activity
LZ559_RS15090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LZ559_RS15090	COG1648	precorrin-2 dehydrogenase activity
LZ559_RS15095	COG0181	hydroxymethylbilane synthase activity
LZ559_RS15100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LZ559_RS15105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LZ559_RS15160	COG2223	nitrite transmembrane transporter activity
LZ559_RS15165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LZ559_RS15185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LZ559_RS15195	COG0842	Transport permease protein
LZ559_RS15195	COG1129	ABC transporter
LZ559_RS15205	COG4991	sh3 domain protein
LZ559_RS15210	COG0515	serine threonine protein kinase
LZ559_RS15210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ559_RS15215	COG0129	dihydroxy-acid dehydratase activity
LZ559_RS15225	COG1082	Xylose isomerase domain protein TIM barrel
LZ559_RS15230	COG0248	Ppx GppA phosphatase
LZ559_RS15250	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LZ559_RS15260	COG1194	a g-specific adenine glycosylase
LZ559_RS15265	COG1595	DNA-templated transcription, initiation
LZ559_RS15275	COG0745	RESPONSE REGULATOR receiver
LZ559_RS15280	COG2205	protein histidine kinase activity
LZ559_RS15285	COG0739	heme binding
LZ559_RS15315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LZ559_RS15335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LZ559_RS15350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LZ559_RS15355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LZ559_RS15380	COG2197	response regulator
LZ559_RS15395	COG0649	NAD binding
LZ559_RS15410	COG1174	glycine betaine transport
LZ559_RS15415	COG1174	glycine betaine transport
LZ559_RS15420	COG1125	glycine betaine transport
LZ559_RS15420	COG0517	IMP dehydrogenase activity
LZ559_RS15430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LZ559_RS15430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LZ559_RS15445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LZ559_RS15450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LZ559_RS15460	COG0302	gtp cyclohydrolase
LZ559_RS15475	COG0037	tRNA processing
LZ559_RS15485	COG2027	D-alanyl-D-alanine carboxypeptidase
LZ559_RS15490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LZ559_RS15500	COG0586	Pfam SNARE associated Golgi protein
LZ559_RS15505	COG0393	Putative heavy-metal-binding
LZ559_RS15515	COG0655	NAD(P)H dehydrogenase (quinone) activity
LZ559_RS15520	COG0076	glutamate decarboxylase activity
LZ559_RS15550	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS15595	COG1595	DNA-templated transcription, initiation
LZ559_RS15630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LZ559_RS15655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LZ559_RS15690	COG4585	Histidine kinase
LZ559_RS15695	COG2197	response regulator
LZ559_RS15715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LZ559_RS15790	COG2770	Histidine kinase
LZ559_RS15790	COG2208	phosphoserine phosphatase activity
LZ559_RS15840	COG3842	ATPase activity
LZ559_RS15850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LZ559_RS15865	COG0215	cysteine-tRNA ligase activity
LZ559_RS15870	COG3467	pyridoxamine 5'-phosphate
LZ559_RS15875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LZ559_RS15880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LZ559_RS15885	COG1329	Transcriptional regulator
LZ559_RS15900	COG5002	protein histidine kinase activity
LZ559_RS15915	COG0588	phosphoglycerate mutase activity
LZ559_RS15970	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS16005	COG0789	Transcriptional regulator
LZ559_RS16045	COG4552	Acetyltransferase involved in intracellular survival and related
LZ559_RS16060	COG1490	D-aminoacyl-tRNA deacylase activity
LZ559_RS16070	COG0735	belongs to the Fur family
LZ559_RS16075	COG3485	protocatechuate 3,4-dioxygenase
LZ559_RS16110	COG2897	thiosulfate sulfurtransferase activity
LZ559_RS16135	COG0745	RESPONSE REGULATOR receiver
LZ559_RS16140	COG1609	Transcriptional regulator
LZ559_RS16145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZ559_RS16180	COG0739	heme binding
LZ559_RS16245	COG0737	Belongs to the 5'-nucleotidase family
LZ559_RS16250	COG0456	acetyltransferase
LZ559_RS16260	COG1725	Transcriptional regulator
LZ559_RS16285	COG0406	alpha-ribazole phosphatase activity
LZ559_RS16285	COG0494	nUDIX hydrolase
LZ559_RS16290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LZ559_RS16310	COG0306	phosphate transporter
LZ559_RS16320	COG1937	Protein conserved in bacteria
LZ559_RS16340	COG0671	phosphoesterase, PA-phosphatase related
LZ559_RS16345	COG0741	lytic transglycosylase activity
LZ559_RS16345	COG1196	nuclear chromosome segregation
LZ559_RS16345	COG0739	heme binding
LZ559_RS16415	COG1131	(ABC) transporter
LZ559_RS16425	COG4585	Histidine kinase
LZ559_RS16430	COG2197	response regulator
LZ559_RS16450	COG1846	Transcriptional regulator
LZ559_RS16465	COG1252	NADH dehydrogenase
LZ559_RS16490	COG0579	oxidoreductase
LZ559_RS16495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LZ559_RS16505	COG0667	Aldo Keto reductase
LZ559_RS16510	COG0739	heme binding
LZ559_RS16510	COG0741	lytic transglycosylase activity
LZ559_RS16510	COG1196	nuclear chromosome segregation
LZ559_RS16520	COG0789	Transcriptional regulator
LZ559_RS16530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LZ559_RS16535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LZ559_RS16590	COG0513	Belongs to the DEAD box helicase family
LZ559_RS16600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LZ559_RS16605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LZ559_RS16635	COG0785	Cytochrome C biogenesis protein
LZ559_RS16640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LZ559_RS16640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LZ559_RS16650	COG1643	Atp-dependent helicase
LZ559_RS16675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LZ559_RS16685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LZ559_RS16705	COG1196	nuclear chromosome segregation
LZ559_RS16705	COG0739	heme binding
LZ559_RS16705	COG0741	lytic transglycosylase activity
LZ559_RS16715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LZ559_RS16720	COG0047	phosphoribosylformylglycinamidine synthase activity
LZ559_RS16725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LZ559_RS16760	COG2197	response regulator
LZ559_RS16770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LZ559_RS16785	COG0151	Belongs to the GarS family
LZ559_RS16870	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LZ559_RS16895	COG0490	domain, Protein
LZ559_RS16900	COG0475	glutathione-regulated potassium exporter activity
LZ559_RS16905	COG0181	hydroxymethylbilane synthase activity
LZ559_RS16930	COG2255	four-way junction helicase activity
LZ559_RS16940	COG0180	Tryptophanyl-tRNA synthetase
LZ559_RS16945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS16960	COG1672	PFAM Archaeal ATPase
LZ559_RS16960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LZ559_RS16980	COG0431	NADPH-dependent FMN reductase
LZ559_RS17010	COG2304	oxidoreductase activity
LZ559_RS17015	COG2205	protein histidine kinase activity
LZ559_RS17020	COG0745	RESPONSE REGULATOR receiver
LZ559_RS17025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ559_RS17035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LZ559_RS17050	COG1741	Belongs to the pirin family
LZ559_RS17060	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS17065	COG1362	aminopeptidase activity
LZ559_RS17085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZ559_RS17095	COG2271	Major facilitator Superfamily
LZ559_RS17125	COG0508	dehydrogenase complex catalyzes the overall conversion of
LZ559_RS17130	COG0022	dehydrogenase e1 component
LZ559_RS17155	COG0515	serine threonine protein kinase
LZ559_RS17160	COG0515	serine threonine protein kinase
LZ559_RS17175	COG4591	ABC-type transport system involved in lipoprotein release permease component
LZ559_RS17175	COG1136	(ABC) transporter
LZ559_RS17225	COG1522	sequence-specific DNA binding
LZ559_RS17230	COG1309	transcriptional regulator
LZ559_RS17255	COG3396	Phenylacetate-CoA oxygenase
LZ559_RS17260	COG3460	Phenylacetate-CoA oxygenase
LZ559_RS17265	COG3396	Phenylacetate-CoA oxygenase
LZ559_RS17270	COG2151	metal-sulfur cluster biosynthetic enzyme
LZ559_RS17275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LZ559_RS17300	COG1733	regulation of RNA biosynthetic process
LZ559_RS17305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LZ559_RS17320	COG1716	ATPase activity
LZ559_RS17325	COG1716	ATPase activity
LZ559_RS17340	COG0768	penicillin binding
LZ559_RS17345	COG0515	serine threonine protein kinase
LZ559_RS17350	COG3764	Sortase (surface protein transpeptidase)
LZ559_RS17355	COG3764	Sortase (surface protein transpeptidase)
LZ559_RS17370	COG3764	Sortase (surface protein transpeptidase)
LZ559_RS17385	COG0705	Rhomboid family
LZ559_RS17415	COG0515	serine threonine protein kinase
LZ559_RS17455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LZ559_RS17465	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LZ559_RS17470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LZ559_RS17475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LZ559_RS17480	COG0592	DNA-directed DNA polymerase activity
LZ559_RS17490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LZ559_RS17495	COG0594	ribonuclease P activity
LZ559_RS17500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LZ559_RS17505	COG0706	membrane insertase activity
LZ559_RS17515	COG0357	Ribosomal RNA small subunit methyltransferase G
LZ559_RS17520	COG1192	Involved in chromosome partitioning
LZ559_RS17535	COG3118	belongs to the thioredoxin family
LZ559_RS17540	COG0492	ferredoxin-NADP+ reductase activity
LZ559_RS17550	COG1595	DNA-templated transcription, initiation
LZ559_RS17555	COG0515	serine threonine protein kinase
LZ559_RS17555	COG2815	serine threonine protein kinase
LZ559_RS17570	COG0617	tRNA 3'-terminal CCA addition
LZ559_RS17595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LZ559_RS17620	COG0360	Binds together with S18 to 16S ribosomal RNA
LZ559_RS17625	COG0629	single-stranded DNA binding
LZ559_RS17630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LZ559_RS17635	COG0359	binds to the 23S rRNA
LZ559_RS17645	COG0305	Participates in initiation and elongation during chromosome replication
LZ559_RS17655	COG2945	thiolester hydrolase activity
LZ559_RS17655	COG0596	Alpha beta hydrolase
LZ559_RS17675	COG2814	Major facilitator Superfamily
LZ559_RS17695	COG0626	cystathionine gamma-synthase activity
LZ559_RS17700	COG1950	PFAM Membrane protein of
LZ559_RS17705	COG0662	Cupin 2, conserved barrel domain protein
LZ559_RS17730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LZ559_RS17735	COG3152	Membrane
LZ559_RS17745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LZ559_RS17750	COG1609	Transcriptional regulator
LZ559_RS17755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LZ559_RS17760	COG1271	oxidase subunit
LZ559_RS17765	COG1294	oxidase, subunit
LZ559_RS17770	COG4988	ABC transporter
LZ559_RS17780	COG0561	phosphatase activity
LZ559_RS17790	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LZ559_RS17795	COG0789	Transcriptional regulator
LZ559_RS17810	COG1131	(ABC) transporter
LZ559_RS17835	COG0561	phosphatase activity
LZ559_RS17840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LZ559_RS17845	COG0077	Prephenate dehydratase
LZ559_RS17850	COG2837	iron assimilation
LZ559_RS17855	COG2372	response to copper ion
LZ559_RS17865	COG1999	signal sequence binding
LZ559_RS17885	COG0006	proline dipeptidase activity
LZ559_RS17905	COG0653	protein targeting
LZ559_RS17920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZ559_RS18055	COG3693	PFAM glycoside hydrolase, family 10
LZ559_RS18070	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS18095	COG1595	DNA-templated transcription, initiation
LZ559_RS18100	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS18210	COG1252	NADH dehydrogenase
LZ559_RS18215	COG1595	DNA-templated transcription, initiation
LZ559_RS18235	COG0745	RESPONSE REGULATOR receiver
LZ559_RS18240	COG2205	protein histidine kinase activity
LZ559_RS18245	COG1215	transferase activity, transferring glycosyl groups
LZ559_RS18250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LZ559_RS18265	COG0477	Major facilitator Superfamily
LZ559_RS18280	COG3467	pyridoxamine 5'-phosphate
LZ559_RS18285	COG2353	YceI-like domain
LZ559_RS18310	COG1191	sigma factor activity
LZ559_RS18315	COG1191	sigma factor activity
LZ559_RS18360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LZ559_RS18390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LZ559_RS18415	COG4941	Belongs to the sigma-70 factor family
LZ559_RS18445	COG2268	Band 7 protein
LZ559_RS18505	COG1278	Cold shock
LZ559_RS18510	COG0513	Belongs to the DEAD box helicase family
LZ559_RS18520	COG3594	Acyltransferase
LZ559_RS18525	COG2409	Drug exporters of the RND superfamily
LZ559_RS18535	COG0475	glutathione-regulated potassium exporter activity
LZ559_RS18545	COG0531	amino acid
LZ559_RS18570	COG3585	molybdate ion transport
LZ559_RS18595	COG2124	cytochrome p450
LZ559_RS18620	COG1609	Transcriptional regulator
LZ559_RS18635	COG0745	RESPONSE REGULATOR receiver
LZ559_RS18640	COG2205	protein histidine kinase activity
LZ559_RS18775	COG0277	FAD linked oxidase domain protein
LZ559_RS18885	COG0717	Belongs to the dCTP deaminase family
LZ559_RS18905	COG2181	nitrate reductase activity
LZ559_RS18905	COG0247	lactate metabolic process
LZ559_RS18910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LZ559_RS18915	COG0443	Heat shock 70 kDa protein
LZ559_RS18920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LZ559_RS18925	COG0484	heat shock protein binding
LZ559_RS18930	COG0789	Transcriptional regulator
LZ559_RS18950	COG2197	response regulator
LZ559_RS18960	COG1132	(ABC) transporter
LZ559_RS18970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LZ559_RS18990	COG2226	methyltransferase
LZ559_RS18995	COG0612	Peptidase, M16
LZ559_RS19045	COG0542	response to heat
LZ559_RS19070	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LZ559_RS19085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LZ559_RS19090	COG0191	fructose-bisphosphate aldolase activity
LZ559_RS19095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LZ559_RS19100	COG0477	Major facilitator Superfamily
LZ559_RS19115	COG3844	kynureninase activity
LZ559_RS19125	COG0702	epimerase
LZ559_RS19130	COG4585	Histidine kinase
LZ559_RS19135	COG2197	response regulator
LZ559_RS19160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LZ559_RS19175	COG0592	DNA-directed DNA polymerase activity
LZ559_RS19285	COG3226	Transcriptional regulator
LZ559_RS19290	COG0738	Major facilitator superfamily
LZ559_RS19295	COG0515	serine threonine protein kinase
LZ559_RS19295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ559_RS19305	COG0693	protein deglycase activity
LZ559_RS19310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LZ559_RS19315	COG1802	Transcriptional regulator
LZ559_RS19330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LZ559_RS19335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LZ559_RS19360	COG1595	DNA-templated transcription, initiation
LZ559_RS19385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LZ559_RS19395	COG2755	lipolytic protein G-D-S-L family
LZ559_RS19425	COG2226	methyltransferase
LZ559_RS19440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZ559_RS19440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LZ559_RS19455	COG1937	Protein conserved in bacteria
LZ559_RS19485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LZ559_RS19570	COG1408	metallophosphoesterase
LZ559_RS19575	COG1610	YqeY-like protein
LZ559_RS19580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LZ559_RS19590	COG0003	Pfam Anion-transporting ATPase
LZ559_RS19615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZ559_RS19645	COG2267	carboxylic ester hydrolase activity
LZ559_RS19655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LZ559_RS19660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LZ559_RS19720	COG1205	dead DEAH box helicase
LZ559_RS19720	COG1111	helicase
LZ559_RS19725	COG1366	Belongs to the anti-sigma-factor antagonist family
LZ559_RS19730	COG2172	sigma factor antagonist activity
LZ559_RS19735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LZ559_RS19745	COG2890	protein-(glutamine-N5) methyltransferase activity
LZ559_RS19755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LZ559_RS19755	COG1754	DNA topoisomerase type I activity
LZ559_RS19760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LZ559_RS19765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LZ559_RS19785	COG1278	Cold shock
LZ559_RS19790	COG0513	Belongs to the DEAD box helicase family
LZ559_RS19835	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LZ559_RS19850	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LZ559_RS19855	COG0463	Glycosyl transferase, family 2
LZ559_RS19905	COG1132	(ABC) transporter
LZ559_RS19910	COG1595	DNA-templated transcription, initiation
LZ559_RS19940	COG0604	alcohol dehydrogenase
LZ559_RS19940	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS19940	COG3321	synthase
LZ559_RS19990	COG3293	Transposase
LZ559_RS20025	COG0395	ABC-type sugar transport system, permease component
LZ559_RS20030	COG1175	transmembrane transport
LZ559_RS20055	COG4251	negative regulation of phosphorylation
LZ559_RS20080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LZ559_RS20080	COG1263	PTS System
LZ559_RS20085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LZ559_RS20090	COG1737	Transcriptional regulator
LZ559_RS20125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LZ559_RS20135	COG1984	allophanate hydrolase subunit 2
LZ559_RS20145	COG3142	Participates in the control of copper homeostasis
LZ559_RS20150	COG3973	AAA domain
LZ559_RS20160	COG1061	Type III restriction enzyme res subunit
LZ559_RS20215	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LZ559_RS20220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LZ559_RS20230	COG2814	Major facilitator Superfamily
LZ559_RS20255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LZ559_RS20265	COG2252	PERMEase
LZ559_RS20295	COG0667	Aldo Keto reductase
LZ559_RS20310	COG0671	phosphoesterase, PA-phosphatase related
LZ559_RS20340	COG2267	carboxylic ester hydrolase activity
LZ559_RS20350	COG0515	serine threonine protein kinase
LZ559_RS20355	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS20360	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS20465	COG1132	(ABC) transporter
LZ559_RS20470	COG1132	(ABC) transporter
LZ559_RS20495	COG2197	response regulator
LZ559_RS20510	COG1309	transcriptional regulator
LZ559_RS20570	COG1335	isochorismatase
LZ559_RS20575	COG2226	methyltransferase
LZ559_RS20590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LZ559_RS20620	COG2205	protein histidine kinase activity
LZ559_RS20625	COG0277	FAD linked oxidase domain protein
LZ559_RS20625	COG0247	lactate metabolic process
LZ559_RS20640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LZ559_RS20660	COG0583	DNA-binding transcription factor activity
LZ559_RS20695	COG0300	oxidoreductase activity
LZ559_RS20695	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS20695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS20695	COG3321	synthase
LZ559_RS20700	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LZ559_RS20705	COG2207	Transcriptional regulator
LZ559_RS20715	COG0583	DNA-binding transcription factor activity
LZ559_RS20720	COG5006	permease, DMT superfamily
LZ559_RS20725	COG1051	belongs to the nudix hydrolase family
LZ559_RS20730	COG2318	DinB family
LZ559_RS20745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LZ559_RS20760	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS20765	COG1024	Enoyl-CoA hydratase
LZ559_RS20800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LZ559_RS20830	COG0259	pyridoxamine-phosphate oxidase activity
LZ559_RS20840	COG1136	(ABC) transporter
LZ559_RS20840	COG0577	efflux transmembrane transporter activity
LZ559_RS20845	COG1136	(ABC) transporter
LZ559_RS20845	COG0577	efflux transmembrane transporter activity
LZ559_RS20860	COG0745	RESPONSE REGULATOR receiver
LZ559_RS20865	COG2205	protein histidine kinase activity
LZ559_RS20870	COG4821	SIS domain
LZ559_RS20880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZ559_RS20890	COG1131	(ABC) transporter
LZ559_RS20935	COG1366	Belongs to the anti-sigma-factor antagonist family
LZ559_RS20945	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS20955	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS20960	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS20980	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS21020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LZ559_RS21025	COG1024	Enoyl-CoA hydratase
LZ559_RS21060	COG2072	flavoprotein involved in K transport
LZ559_RS21080	COG0501	Belongs to the peptidase M48B family
LZ559_RS21085	COG0259	pyridoxamine-phosphate oxidase activity
LZ559_RS21105	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS21115	COG1309	transcriptional regulator
LZ559_RS21190	COG1278	Cold shock
LZ559_RS21195	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LZ559_RS21205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LZ559_RS21230	COG2175	clavaminate synthase activity
LZ559_RS21235	COG2226	methyltransferase
LZ559_RS21280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ559_RS21285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ559_RS21290	COG0649	NAD binding
LZ559_RS21300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LZ559_RS21305	COG1034	ATP synthesis coupled electron transport
LZ559_RS21310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LZ559_RS21315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ559_RS21320	COG0839	Belongs to the complex I subunit 6 family
LZ559_RS21325	COG0713	ATP synthesis coupled electron transport
LZ559_RS21330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LZ559_RS21340	COG1007	ATP synthesis coupled electron transport
LZ559_RS21355	COG0596	Alpha beta hydrolase
LZ559_RS21365	COG2197	response regulator
LZ559_RS21390	COG0179	Fumarylacetoacetate (FAA) hydrolase
LZ559_RS21400	COG3104	oligopeptide transport
LZ559_RS21405	COG0142	geranyltranstransferase activity
LZ559_RS21435	COG0515	serine threonine protein kinase
LZ559_RS21435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ559_RS21440	COG1917	Cupin 2, conserved barrel domain protein
LZ559_RS21460	COG0561	phosphatase activity
LZ559_RS21475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LZ559_RS21480	COG0583	DNA-binding transcription factor activity
LZ559_RS21500	COG1064	alcohol dehydrogenase
LZ559_RS21540	COG0702	epimerase
LZ559_RS21545	COG1733	regulation of RNA biosynthetic process
LZ559_RS21550	COG1013	pyruvate-flavodoxin oxidoreductase activity
LZ559_RS21555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LZ559_RS21555	COG0674	pyruvate-flavodoxin oxidoreductase activity
LZ559_RS21575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ559_RS21580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ559_RS21585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ559_RS21590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LZ559_RS21595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ559_RS21600	COG0839	Belongs to the complex I subunit 6 family
LZ559_RS21605	COG0713	ATP synthesis coupled electron transport
LZ559_RS21610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LZ559_RS21620	COG1007	ATP synthesis coupled electron transport
LZ559_RS21630	COG0501	Belongs to the peptidase M48B family
LZ559_RS21635	COG3304	Inner membrane component domain
LZ559_RS21650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LZ559_RS21655	COG1666	GTP binding
LZ559_RS21665	COG0702	epimerase
LZ559_RS21685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LZ559_RS21690	COG2030	dehydratase
LZ559_RS21700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LZ559_RS21715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LZ559_RS21720	COG0436	Aminotransferase
LZ559_RS21740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LZ559_RS21745	COG0081	regulation of translation
LZ559_RS21755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LZ559_RS21760	COG0222	ribosome binding
LZ559_RS21765	COG0085	RNA polymerase activity
LZ559_RS21770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LZ559_RS21775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LZ559_RS21780	COG0049	tRNA binding
LZ559_RS21785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LZ559_RS21790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LZ559_RS21810	COG0051	transcription antitermination factor activity, RNA binding
LZ559_RS21815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LZ559_RS21820	COG0088	Forms part of the polypeptide exit tunnel
LZ559_RS21825	COG0089	rRNA binding
LZ559_RS21830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LZ559_RS21835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LZ559_RS21840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LZ559_RS21845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LZ559_RS21850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LZ559_RS21855	COG0255	Belongs to the universal ribosomal protein uL29 family
LZ559_RS21860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LZ559_RS21865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LZ559_RS21870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LZ559_RS21875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LZ559_RS21880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LZ559_RS21885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LZ559_RS21890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LZ559_RS21895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LZ559_RS21900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LZ559_RS21910	COG0200	Binds to the 23S rRNA
LZ559_RS21920	COG0563	adenylate kinase activity
LZ559_RS21930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LZ559_RS21935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LZ559_RS21940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LZ559_RS21945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LZ559_RS21950	COG0202	RNA polymerase activity
LZ559_RS21955	COG0203	ribosomal protein L17
LZ559_RS21960	COG0101	tRNA pseudouridine synthase activity
LZ559_RS21970	COG0488	(ABC) transporter
LZ559_RS21975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LZ559_RS21980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LZ559_RS21985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LZ559_RS21990	COG2770	Histidine kinase
LZ559_RS21990	COG2208	phosphoserine phosphatase activity
LZ559_RS22000	COG1072	(Pantothenic acid kinase))
LZ559_RS22050	COG1309	transcriptional regulator
LZ559_RS22065	COG0596	Alpha beta hydrolase
LZ559_RS22070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS22075	COG3795	YCII-related domain
LZ559_RS22080	COG4941	Belongs to the sigma-70 factor family
LZ559_RS22090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZ559_RS22095	COG0736	holo-[acyl-carrier-protein] synthase activity
LZ559_RS22100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LZ559_RS22100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LZ559_RS22105	COG3189	MarR family transcriptional regulator
LZ559_RS22110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LZ559_RS22120	COG0802	atpase or kinase
LZ559_RS22145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LZ559_RS22165	COG0726	polysaccharide deacetylase
LZ559_RS22175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LZ559_RS22190	COG0395	ABC-type sugar transport system, permease component
LZ559_RS22195	COG1175	transmembrane transport
LZ559_RS22205	COG1609	Transcriptional regulator
LZ559_RS22230	COG0583	DNA-binding transcription factor activity
LZ559_RS22245	COG1595	DNA-templated transcription, initiation
LZ559_RS22255	COG0516	GMP reductase activity
LZ559_RS22285	COG0515	serine threonine protein kinase
LZ559_RS22290	COG0515	serine threonine protein kinase
LZ559_RS22290	COG2815	serine threonine protein kinase
LZ559_RS22295	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS22315	COG0519	Catalyzes the synthesis of GMP from XMP
LZ559_RS22315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LZ559_RS22355	COG2197	response regulator
LZ559_RS22360	COG0791	NLP P60 protein
LZ559_RS22380	COG0739	heme binding
LZ559_RS22390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LZ559_RS22410	COG0714	Associated with various cellular activities
LZ559_RS22420	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LZ559_RS22435	COG0045	succinate-CoA ligase (ADP-forming) activity
LZ559_RS22465	COG0138	bifunctional purine biosynthesis protein purh
LZ559_RS22480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LZ559_RS22495	COG0039	L-malate dehydrogenase activity
LZ559_RS22500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ559_RS22505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ559_RS22515	COG0754	glutathionylspermidine amidase activity
LZ559_RS22520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZ559_RS22525	COG0180	Tryptophanyl-tRNA synthetase
LZ559_RS22545	COG1295	ribonuclease BN
LZ559_RS22550	COG1686	Belongs to the peptidase S11 family
LZ559_RS22560	COG1408	metallophosphoesterase
LZ559_RS22595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LZ559_RS22610	COG2009	succinate dehydrogenase
LZ559_RS22665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LZ559_RS22670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LZ559_RS22675	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LZ559_RS22680	COG1595	DNA-templated transcription, initiation
LZ559_RS22705	COG1216	Glycosyl transferase, family 2
LZ559_RS22735	COG1216	Glycosyl transferase, family 2
LZ559_RS22745	COG1083	cytidylyl-transferase
LZ559_RS22750	COG2089	acid synthase
LZ559_RS22760	COG1473	amidohydrolase
LZ559_RS22760	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LZ559_RS22765	COG1744	ABC transporter substrate-binding protein PnrA-like
LZ559_RS22770	COG3845	ABC transporter
LZ559_RS22775	COG4603	Belongs to the binding-protein-dependent transport system permease family
LZ559_RS22780	COG1079	Belongs to the binding-protein-dependent transport system permease family
LZ559_RS22800	COG1404	Belongs to the peptidase S8 family
LZ559_RS22820	COG2814	Major facilitator Superfamily
LZ559_RS22825	COG0583	DNA-binding transcription factor activity
LZ559_RS22840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LZ559_RS22865	COG2205	protein histidine kinase activity
LZ559_RS22870	COG0745	RESPONSE REGULATOR receiver
LZ559_RS22875	COG1595	DNA-templated transcription, initiation
LZ559_RS22900	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS22905	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS22920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LZ559_RS22950	COG4770	biotin carboxylase activity
LZ559_RS22960	COG0424	maF-like protein
LZ559_RS22970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LZ559_RS22985	COG1024	Enoyl-CoA hydratase
LZ559_RS23010	COG1376	ErfK ybiS ycfS ynhG family protein
LZ559_RS23030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LZ559_RS23035	COG1396	sequence-specific DNA binding
LZ559_RS23050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ559_RS23090	COG0745	RESPONSE REGULATOR receiver
LZ559_RS23095	COG4999	Histidine kinase
LZ559_RS23095	COG3850	Histidine kinase
LZ559_RS23095	COG3437	response regulator, receiver
LZ559_RS23095	COG2205	protein histidine kinase activity
LZ559_RS23105	COG2172	sigma factor antagonist activity
LZ559_RS23110	COG1366	Belongs to the anti-sigma-factor antagonist family
LZ559_RS23115	COG1366	Belongs to the anti-sigma-factor antagonist family
LZ559_RS23120	COG2255	four-way junction helicase activity
LZ559_RS23125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LZ559_RS23140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZ559_RS23150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LZ559_RS23170	COG1331	Highly conserved protein containing a thioredoxin domain
LZ559_RS23180	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LZ559_RS23195	COG0436	Aminotransferase
LZ559_RS23215	COG1733	regulation of RNA biosynthetic process
LZ559_RS23235	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LZ559_RS23250	COG1414	Transcriptional regulator
LZ559_RS23255	COG0251	oxidation-reduction process
LZ559_RS23260	COG2610	gluconate transmembrane transporter activity
LZ559_RS23295	COG2894	cell division
LZ559_RS23330	COG2197	response regulator
LZ559_RS23350	COG2885	chlorophyll binding
LZ559_RS23410	COG0667	Aldo Keto reductase
LZ559_RS23415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LZ559_RS23420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LZ559_RS23435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ559_RS23440	COG0450	alkyl hydroperoxide reductase
LZ559_RS23455	COG1136	(ABC) transporter
LZ559_RS23490	COG0114	fumarate hydratase activity
LZ559_RS23500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS23515	COG1362	aminopeptidase activity
LZ559_RS23540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LZ559_RS23540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LZ559_RS23565	COG0778	Nitroreductase
LZ559_RS23570	COG1722	exodeoxyribonuclease VII activity
LZ559_RS23575	COG1570	exodeoxyribonuclease VII activity
LZ559_RS23585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LZ559_RS23600	COG0012	GTP binding
LZ559_RS23680	COG1842	Phage shock protein A
LZ559_RS23690	COG0463	Glycosyl transferase, family 2
LZ559_RS23740	COG1309	transcriptional regulator
LZ559_RS23760	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS23795	COG2770	Histidine kinase
LZ559_RS23795	COG2208	phosphoserine phosphatase activity
LZ559_RS23810	COG0702	epimerase
LZ559_RS23815	COG3631	Ketosteroid isomerase-related protein
LZ559_RS23875	COG0395	ABC-type sugar transport system, permease component
LZ559_RS23880	COG1175	transmembrane transport
LZ559_RS23900	COG1609	Transcriptional regulator
LZ559_RS23910	COG1217	gtp-binding protein TYPA
LZ559_RS23915	COG4166	transmembrane transport
LZ559_RS23920	COG0601	transmembrane transport
LZ559_RS23925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LZ559_RS23935	COG4608	Belongs to the ABC transporter superfamily
LZ559_RS23940	COG4166	transmembrane transport
LZ559_RS23945	COG0601	transmembrane transport
LZ559_RS23950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LZ559_RS23955	COG0444	Belongs to the ABC transporter superfamily
LZ559_RS23960	COG4608	Belongs to the ABC transporter superfamily
LZ559_RS23980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LZ559_RS24005	COG0110	maltose O-acetyltransferase activity
LZ559_RS24020	COG0515	serine threonine protein kinase
LZ559_RS24030	COG1132	(ABC) transporter
LZ559_RS24035	COG1132	(ABC) transporter
LZ559_RS24040	COG2197	response regulator
LZ559_RS24045	COG2912	Transglutaminase-like superfamily
LZ559_RS24075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LZ559_RS24080	COG1611	Belongs to the LOG family
LZ559_RS24085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LZ559_RS24095	COG0519	Catalyzes the synthesis of GMP from XMP
LZ559_RS24100	COG1024	Enoyl-CoA hydratase
LZ559_RS24115	COG1595	DNA-templated transcription, initiation
LZ559_RS24125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZ559_RS24130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LZ559_RS24165	COG0598	Magnesium transport protein CorA
LZ559_RS24175	COG2814	Major facilitator Superfamily
LZ559_RS24185	COG0613	PHP domain protein
LZ559_RS24190	COG2095	MarC family integral membrane protein
LZ559_RS24200	COG1432	Conserved Protein
LZ559_RS24210	COG0513	Belongs to the DEAD box helicase family
LZ559_RS24305	COG0210	DNA helicase
LZ559_RS24350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZ559_RS24400	COG3480	Lon protease (S16) C-terminal proteolytic domain
LZ559_RS24410	COG1615	UPF0182 protein
LZ559_RS24435	COG0753	catalase activity
LZ559_RS24445	COG0483	inositol monophosphate 1-phosphatase activity
LZ559_RS24455	COG2076	Multidrug Resistance protein
LZ559_RS24460	COG1162	GTPase activity
LZ559_RS24465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LZ559_RS24475	COG2135	peptidase activity
LZ559_RS24485	COG1595	DNA-templated transcription, initiation
LZ559_RS24490	COG5662	AntiSigma factor
LZ559_RS24510	COG0242	peptide deformylase activity
LZ559_RS24535	COG1131	(ABC) transporter
LZ559_RS24565	COG1966	Carbon starvation protein
LZ559_RS24580	COG1216	Glycosyl transferase, family 2
LZ559_RS24580	COG1442	glycosyl transferase family 8
LZ559_RS24590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZ559_RS24595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ559_RS24600	COG0109	protoheme IX farnesyltransferase activity
LZ559_RS24605	COG1215	transferase activity, transferring glycosyl groups
LZ559_RS24625	COG0667	Aldo Keto reductase
LZ559_RS24635	COG2182	Extracellular solute-binding protein
LZ559_RS24640	COG1175	transmembrane transport
LZ559_RS24645	COG0395	ABC-type sugar transport system, permease component
LZ559_RS24650	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ559_RS24655	COG0363	glucosamine-6-phosphate deaminase activity
LZ559_RS24660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZ559_RS24675	COG1597	lipid kinase activity
LZ559_RS24690	COG2172	sigma factor antagonist activity
LZ559_RS24705	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LZ559_RS24710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LZ559_RS24710	COG1017	nitric oxide dioxygenase activity
LZ559_RS24715	COG1959	2 iron, 2 sulfur cluster binding
LZ559_RS24720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LZ559_RS24725	COG0142	geranyltranstransferase activity
LZ559_RS24795	COG4977	sequence-specific DNA binding
LZ559_RS24805	COG0789	Transcriptional regulator
LZ559_RS24810	COG0659	secondary active sulfate transmembrane transporter activity
LZ559_RS24835	COG4106	trans-aconitate 2-methyltransferase activity
LZ559_RS24840	COG1126	abc transporter atp-binding protein
LZ559_RS24845	COG0765	amino acid transport
LZ559_RS24850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS24855	COG0281	malic enzyme
LZ559_RS24860	COG0604	alcohol dehydrogenase
LZ559_RS24880	COG0542	response to heat
LZ559_RS24905	COG0508	dehydrogenase complex catalyzes the overall conversion of
LZ559_RS24905	COG0567	Dehydrogenase, E1 component
LZ559_RS24910	COG2205	protein histidine kinase activity
LZ559_RS24915	COG0745	RESPONSE REGULATOR receiver
LZ559_RS24925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LZ559_RS24930	COG0726	polysaccharide deacetylase
LZ559_RS24945	COG5002	protein histidine kinase activity
LZ559_RS24985	COG1309	transcriptional regulator
LZ559_RS25005	COG0154	amidase activity
LZ559_RS25010	COG0768	penicillin binding
LZ559_RS25025	COG2205	protein histidine kinase activity
LZ559_RS25045	COG3285	dna ligase
LZ559_RS25045	COG1793	dna ligase
LZ559_RS25050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LZ559_RS25065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LZ559_RS25080	COG0454	-acetyltransferase
LZ559_RS25085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LZ559_RS25120	COG0662	Cupin 2, conserved barrel domain protein
LZ559_RS25125	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS25135	COG2313	pseudouridylate synthase activity
LZ559_RS25140	COG0546	phosphoglycolate phosphatase activity
LZ559_RS25165	COG0018	arginyl-trna synthetase
LZ559_RS25170	COG0019	diaminopimelate decarboxylase activity
LZ559_RS25175	COG0460	homoserine dehydrogenase
LZ559_RS25180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LZ559_RS25185	COG0083	homoserine kinase activity
LZ559_RS25200	COG1316	TRANSCRIPTIONal
LZ559_RS25205	COG0254	rRNA binding
LZ559_RS25210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LZ559_RS25215	COG2890	protein-(glutamine-N5) methyltransferase activity
LZ559_RS25225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LZ559_RS25230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LZ559_RS25250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LZ559_RS25255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LZ559_RS25260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LZ559_RS25265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LZ559_RS25270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LZ559_RS25275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LZ559_RS25280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LZ559_RS25295	COG2197	response regulator
LZ559_RS25300	COG4585	Histidine kinase
LZ559_RS25325	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ559_RS25340	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LZ559_RS25375	COG1131	(ABC) transporter
LZ559_RS25395	COG0183	Belongs to the thiolase family
LZ559_RS25410	COG0745	RESPONSE REGULATOR receiver
LZ559_RS25415	COG5000	phosphorelay sensor kinase activity
LZ559_RS25415	COG5002	protein histidine kinase activity
LZ559_RS25485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LZ559_RS25485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LZ559_RS25490	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LZ559_RS25525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LZ559_RS25530	COG0857	belongs to the CobB CobQ family
LZ559_RS25530	COG0280	phosphate acetyltransferase
LZ559_RS25535	COG0205	6-phosphofructokinase activity
LZ559_RS25545	COG4565	transcriptional regulatory protein
LZ559_RS25550	COG3290	protein histidine kinase activity
LZ559_RS25555	COG1301	dicarboxylic acid transport
LZ559_RS25570	COG3118	belongs to the thioredoxin family
LZ559_RS25570	COG0492	ferredoxin-NADP+ reductase activity
LZ559_RS25580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LZ559_RS25585	COG3281	Trehalose synthase
LZ559_RS25590	COG0366	Alpha amylase catalytic
LZ559_RS25595	COG0366	Alpha amylase catalytic
LZ559_RS25600	COG0058	SHG alpha-glucan phosphorylase activity
LZ559_RS25635	COG1597	lipid kinase activity
LZ559_RS25640	COG1132	(ABC) transporter
LZ559_RS25645	COG1132	(ABC) transporter
LZ559_RS25650	COG1131	(ABC) transporter
LZ559_RS25665	COG2197	response regulator
LZ559_RS25800	COG1506	peptidase
LZ559_RS25800	COG0823	Involved in the tonB-independent uptake of proteins
LZ559_RS25810	COG0464	growth
LZ559_RS25815	COG2235	arginine
LZ559_RS25850	COG4566	intracellular signal transduction
LZ559_RS25870	COG1760	l-serine dehydratase
LZ559_RS25875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LZ559_RS25880	COG0509	glycine decarboxylation via glycine cleavage system
LZ559_RS25885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LZ559_RS25905	COG0747	negative chemotaxis
LZ559_RS25910	COG0601	transmembrane transport
LZ559_RS25915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LZ559_RS25925	COG4608	Belongs to the ABC transporter superfamily
LZ559_RS25930	COG2860	membrane
LZ559_RS25945	COG0477	Major facilitator Superfamily
LZ559_RS25990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LZ559_RS25995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ559_RS26015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ559_RS26060	COG1271	oxidase subunit
LZ559_RS26065	COG0583	DNA-binding transcription factor activity
LZ559_RS26075	COG0604	alcohol dehydrogenase
LZ559_RS26085	COG0667	Aldo Keto reductase
LZ559_RS26105	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS26125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS26180	COG0477	Major facilitator Superfamily
LZ559_RS26225	COG0482	sulfurtransferase activity
LZ559_RS26245	COG4221	oxidoreductase activity
LZ559_RS26255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LZ559_RS26265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LZ559_RS26270	COG0154	amidase activity
LZ559_RS26280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LZ559_RS26285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LZ559_RS26295	COG2409	Drug exporters of the RND superfamily
LZ559_RS26315	COG2197	response regulator
LZ559_RS26325	COG2133	pyrroloquinoline quinone binding
LZ559_RS26330	COG0667	Aldo Keto reductase
LZ559_RS26340	COG3300	MHYT domain
LZ559_RS26340	COG5001	Diguanylate cyclase
LZ559_RS26350	COG0440	acetolactate synthase activity
LZ559_RS26355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LZ559_RS26360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZ559_RS26380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LZ559_RS26385	COG2508	Transcriptional regulator
LZ559_RS26390	COG0506	proline dehydrogenase activity
LZ559_RS26395	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS26410	COG0473	3-isopropylmalate dehydrogenase activity
LZ559_RS26415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LZ559_RS26420	COG2957	Belongs to the agmatine deiminase family
LZ559_RS26430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LZ559_RS26435	COG1609	Transcriptional regulator
LZ559_RS26445	COG4608	Belongs to the ABC transporter superfamily
LZ559_RS26450	COG0601	transmembrane transport
LZ559_RS26455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LZ559_RS26460	COG0444	Belongs to the ABC transporter superfamily
LZ559_RS26470	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ559_RS26485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LZ559_RS26495	COG1309	transcriptional regulator
LZ559_RS26505	COG3708	Transcriptional regulator
LZ559_RS26505	COG2207	Transcriptional regulator
LZ559_RS26530	COG0492	ferredoxin-NADP+ reductase activity
LZ559_RS26570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS26575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS26580	COG1120	ATPase activity
LZ559_RS26585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LZ559_RS26610	COG0366	Alpha amylase catalytic
LZ559_RS26610	COG1470	cell adhesion involved in biofilm formation
LZ559_RS26615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LZ559_RS26635	COG2018	Roadblock/LC7 domain
LZ559_RS26655	COG2018	Roadblock/LC7 domain
LZ559_RS26660	COG5002	protein histidine kinase activity
LZ559_RS26670	COG0179	Fumarylacetoacetate (FAA) hydrolase
LZ559_RS26675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LZ559_RS26715	COG1414	Transcriptional regulator
LZ559_RS26720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LZ559_RS26725	COG0066	3-isopropylmalate dehydratase activity
LZ559_RS26735	COG0776	regulation of translation
LZ559_RS26745	COG1920	GTP binding
LZ559_RS26755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LZ559_RS26760	COG1181	Belongs to the D-alanine--D-alanine ligase family
LZ559_RS26780	COG0351	phosphomethylpyrimidine kinase
LZ559_RS26785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LZ559_RS26790	COG1461	Dihydroxyacetone kinase
LZ559_RS26795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LZ559_RS26800	COG0742	ribosomal rna small subunit methyltransferase
LZ559_RS26805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LZ559_RS26820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LZ559_RS26825	COG0571	ribonuclease III activity
LZ559_RS26830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LZ559_RS26835	COG1733	regulation of RNA biosynthetic process
LZ559_RS26850	COG0546	phosphoglycolate phosphatase activity
LZ559_RS26885	COG2340	Cysteine-rich secretory protein family
LZ559_RS26890	COG1254	Belongs to the acylphosphatase family
LZ559_RS26900	COG1196	nuclear chromosome segregation
LZ559_RS26905	COG0477	Major facilitator Superfamily
LZ559_RS26940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LZ559_RS26960	COG0228	four-way junction DNA binding
LZ559_RS26965	COG1837	Belongs to the UPF0109 family
LZ559_RS26970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LZ559_RS26975	COG0336	Belongs to the RNA methyltransferase TrmD family
LZ559_RS26980	COG0335	large ribosomal subunit rRNA binding
LZ559_RS26990	COG0681	Belongs to the peptidase S26 family
LZ559_RS26995	COG0681	Belongs to the peptidase S26 family
LZ559_RS27015	COG0792	nuclease activity
LZ559_RS27030	COG1191	sigma factor activity
LZ559_RS27045	COG0052	Belongs to the universal ribosomal protein uS2 family
LZ559_RS27050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LZ559_RS27055	COG0528	UMP kinase activity
LZ559_RS27060	COG0233	cytoplasmic translational termination
LZ559_RS27065	COG0575	Belongs to the CDS family
LZ559_RS27140	COG2226	methyltransferase
LZ559_RS27145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LZ559_RS27160	COG3842	ATPase activity
LZ559_RS27165	COG2197	response regulator
LZ559_RS27170	COG4585	Histidine kinase
LZ559_RS27180	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS27195	COG4181	ATPase activity
LZ559_RS27200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LZ559_RS27210	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS27230	COG2197	response regulator
LZ559_RS27235	COG4585	Histidine kinase
LZ559_RS27250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LZ559_RS27270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LZ559_RS27275	COG3842	ATPase activity
LZ559_RS27280	COG1176	ABC-type spermidine putrescine transport system, permease component I
LZ559_RS27285	COG1177	transmembrane transport
LZ559_RS27290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZ559_RS27320	COG2508	Transcriptional regulator
LZ559_RS27325	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS27335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LZ559_RS27340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LZ559_RS27345	COG0750	zinc metalloprotease
LZ559_RS27350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LZ559_RS27365	COG0442	prolyl-tRNA aminoacylation
LZ559_RS27385	COG0779	Required for maturation of 30S ribosomal subunits
LZ559_RS27400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LZ559_RS27410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LZ559_RS27415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LZ559_RS27450	COG4608	Belongs to the ABC transporter superfamily
LZ559_RS27460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LZ559_RS27465	COG0601	transmembrane transport
LZ559_RS27470	COG0747	negative chemotaxis
LZ559_RS27475	COG0455	bacterial-type flagellum organization
LZ559_RS27495	COG3266	domain, Protein
LZ559_RS27500	COG1404	Belongs to the peptidase S8 family
LZ559_RS27515	COG1404	Belongs to the peptidase S8 family
LZ559_RS27525	COG4842	Belongs to the WXG100 family
LZ559_RS27530	COG1674	ftsk spoiiie
LZ559_RS27540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LZ559_RS27545	COG1185	polyribonucleotide nucleotidyltransferase activity
LZ559_RS27550	COG0612	Peptidase, M16
LZ559_RS27555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LZ559_RS27575	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LZ559_RS27580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LZ559_RS27585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LZ559_RS27610	COG2770	Histidine kinase
LZ559_RS27610	COG2208	phosphoserine phosphatase activity
LZ559_RS27615	COG4999	Histidine kinase
LZ559_RS27615	COG3850	Histidine kinase
LZ559_RS27615	COG2205	protein histidine kinase activity
LZ559_RS27615	COG3437	response regulator, receiver
LZ559_RS27625	COG1674	ftsk spoiiie
LZ559_RS27635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LZ559_RS27645	COG1058	Belongs to the CinA family
LZ559_RS27645	COG1546	Belongs to the CinA family
LZ559_RS27650	COG1396	sequence-specific DNA binding
LZ559_RS27655	COG0783	Belongs to the Dps family
LZ559_RS27670	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS27675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LZ559_RS27680	COG1201	RNA secondary structure unwinding
LZ559_RS27685	COG1917	Cupin 2, conserved barrel domain protein
LZ559_RS27685	COG2207	Transcriptional regulator
LZ559_RS27725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LZ559_RS27750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ559_RS27755	COG0765	amino acid transport
LZ559_RS27760	COG0765	amino acid transport
LZ559_RS27765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS27770	COG1126	abc transporter atp-binding protein
LZ559_RS27775	COG0745	RESPONSE REGULATOR receiver
LZ559_RS27780	COG2205	protein histidine kinase activity
LZ559_RS27790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LZ559_RS27805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LZ559_RS27815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LZ559_RS27820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZ559_RS27830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LZ559_RS27870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LZ559_RS27875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LZ559_RS27880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LZ559_RS27915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LZ559_RS27950	COG1802	Transcriptional regulator
LZ559_RS27955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LZ559_RS27980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ559_RS27985	COG4565	transcriptional regulatory protein
LZ559_RS27990	COG3290	protein histidine kinase activity
LZ559_RS28000	COG0372	Belongs to the citrate synthase family
LZ559_RS28005	COG0372	Belongs to the citrate synthase family
LZ559_RS28015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LZ559_RS28020	COG0612	Peptidase, M16
LZ559_RS28035	COG1802	Transcriptional regulator
LZ559_RS28040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LZ559_RS28045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ559_RS28045	COG0045	succinate-CoA ligase (ADP-forming) activity
LZ559_RS28045	COG1042	CoA-binding domain protein
LZ559_RS28060	COG1435	thymidine kinase activity
LZ559_RS28100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LZ559_RS28115	COG0745	RESPONSE REGULATOR receiver
LZ559_RS28120	COG2205	protein histidine kinase activity
LZ559_RS28145	COG0756	dUTP diphosphatase activity
LZ559_RS28155	COG4591	ABC-type transport system involved in lipoprotein release permease component
LZ559_RS28155	COG1136	(ABC) transporter
LZ559_RS28185	COG0569	domain protein
LZ559_RS28190	COG0531	amino acid
LZ559_RS28195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LZ559_RS28360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS28385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS28410	COG1120	ATPase activity
LZ559_RS28415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LZ559_RS28425	COG0803	Belongs to the bacterial solute-binding protein 9 family
LZ559_RS28455	COG2843	Capsule synthesis protein
LZ559_RS28485	COG0477	Major facilitator Superfamily
LZ559_RS28495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZ559_RS28505	COG0446	pyridine nucleotide-disulphide oxidoreductase
LZ559_RS28515	COG3938	Belongs to the proline racemase family
LZ559_RS28520	COG1802	Transcriptional regulator
LZ559_RS28525	COG3291	Pkd domain containing protein
LZ559_RS28535	COG1280	lysine exporter protein (LysE YggA)
LZ559_RS28540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ559_RS28545	COG3046	protein related to deoxyribodipyrimidine photolyase
LZ559_RS28570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS28575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS28580	COG3467	pyridoxamine 5'-phosphate
LZ559_RS28590	COG0586	Pfam SNARE associated Golgi protein
LZ559_RS28595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZ559_RS28600	COG1349	DNA-binding transcription factor activity
LZ559_RS28605	COG1799	cell septum assembly
LZ559_RS28625	COG2040	homocysteine
LZ559_RS28635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LZ559_RS28645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LZ559_RS28650	COG0531	amino acid
LZ559_RS28660	COG1024	Enoyl-CoA hydratase
LZ559_RS28710	COG2111	Na H antiporter
LZ559_RS28710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LZ559_RS28715	COG1006	Multisubunit Na H antiporter MnhC subunit
LZ559_RS28720	COG0651	ATP synthesis coupled electron transport
LZ559_RS28735	COG1320	monovalent cation:proton antiporter activity
LZ559_RS28755	COG0297	glycogen (starch) synthase activity
LZ559_RS28760	COG0489	protein tyrosine kinase activity
LZ559_RS28800	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LZ559_RS28805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ559_RS28810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LZ559_RS28820	COG1366	Belongs to the anti-sigma-factor antagonist family
LZ559_RS28820	COG2172	sigma factor antagonist activity
LZ559_RS28820	COG2208	phosphoserine phosphatase activity
LZ559_RS28840	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS28870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ559_RS28915	COG2319	Wd-40 repeat
LZ559_RS28945	COG1175	transmembrane transport
LZ559_RS28950	COG0395	ABC-type sugar transport system, permease component
LZ559_RS28970	COG1482	cell wall glycoprotein biosynthetic process
LZ559_RS28980	COG4124	Belongs to the glycosyl hydrolase 26 family
LZ559_RS28985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LZ559_RS28990	COG3548	integral membrane protein
LZ559_RS29015	COG1742	UPF0060 membrane protein
LZ559_RS29030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LZ559_RS29040	COG0588	phosphoglycerate mutase activity
LZ559_RS29050	COG1653	transport
LZ559_RS29055	COG1175	transmembrane transport
LZ559_RS29060	COG0395	ABC-type sugar transport system, permease component
LZ559_RS29065	COG1940	carbohydrate kinase activity
LZ559_RS29070	COG4213	ABC transporter substrate-binding protein
LZ559_RS29080	COG4214	carbohydrate transport
LZ559_RS29085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LZ559_RS29090	COG0531	amino acid
LZ559_RS29105	COG1316	TRANSCRIPTIONal
LZ559_RS29110	COG1024	Enoyl-CoA hydratase
LZ559_RS29110	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ559_RS29115	COG0183	Belongs to the thiolase family
LZ559_RS29120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LZ559_RS29140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LZ559_RS29145	COG0446	pyridine nucleotide-disulphide oxidoreductase
LZ559_RS29155	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LZ559_RS29160	COG3253	May function as heme-dependent peroxidase
LZ559_RS29175	COG3220	belongs to the UPF0276 family
LZ559_RS29230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LZ559_RS29235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ559_RS29275	COG1653	transport
LZ559_RS29355	COG2267	carboxylic ester hydrolase activity
LZ559_RS29365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ559_RS29365	COG0515	serine threonine protein kinase
LZ559_RS29380	COG1063	alcohol dehydrogenase
LZ559_RS29385	COG0156	8-amino-7-oxononanoate synthase activity
LZ559_RS29390	COG0583	DNA-binding transcription factor activity
LZ559_RS29400	COG0477	Major facilitator Superfamily
LZ559_RS29410	COG0346	lactoylglutathione lyase activity
LZ559_RS29430	COG2723	6-phospho-beta-galactosidase activity
LZ559_RS29495	COG1175	transmembrane transport
LZ559_RS29515	COG1404	Belongs to the peptidase S8 family
LZ559_RS29535	COG1132	(ABC) transporter
LZ559_RS29540	COG1132	(ABC) transporter
LZ559_RS29545	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LZ559_RS29550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS29555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS29560	COG1120	ATPase activity
LZ559_RS29570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LZ559_RS29575	COG2226	methyltransferase
LZ559_RS29585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LZ559_RS29590	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LZ559_RS29610	COG0529	Catalyzes the synthesis of activated sulfate
LZ559_RS29615	COG0175	sulfate reduction
LZ559_RS29640	COG1191	sigma factor activity
LZ559_RS29655	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS29675	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ559_RS29680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LZ559_RS29685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LZ559_RS29690	COG0583	DNA-binding transcription factor activity
LZ559_RS29695	COG0183	Belongs to the thiolase family
LZ559_RS29700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ559_RS29745	COG1162	GTPase activity
LZ559_RS29775	COG0028	Belongs to the TPP enzyme family
LZ559_RS29805	COG1802	Transcriptional regulator
LZ559_RS29830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LZ559_RS29835	COG2252	PERMEase
LZ559_RS29840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LZ559_RS29840	COG3608	succinylglutamate desuccinylase aspartoacylase
LZ559_RS29845	COG1404	Belongs to the peptidase S8 family
LZ559_RS29870	COG1309	transcriptional regulator
LZ559_RS29890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ559_RS29920	COG0435	Glutathione S-transferase
LZ559_RS29935	COG2197	response regulator
LZ559_RS29940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LZ559_RS29945	COG0318	PFAM AMP-dependent synthetase and ligase
LZ559_RS29965	COG3960	tartronate-semialdehyde synthase activity
LZ559_RS29985	COG0753	catalase activity
LZ559_RS29990	COG2084	Dehydrogenase
LZ559_RS29995	COG3622	Belongs to the hyi family
LZ559_RS30000	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LZ559_RS30005	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ559_RS30010	COG0395	ABC-type sugar transport system, permease component
LZ559_RS30015	COG1175	transmembrane transport
LZ559_RS30025	COG2188	Transcriptional regulator
LZ559_RS30030	COG2706	6-phosphogluconolactonase activity
LZ559_RS30050	COG2351	hydroxyisourate hydrolase activity
LZ559_RS30060	COG2233	PERMEase
LZ559_RS30070	COG2233	PERMEase
LZ559_RS30095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LZ559_RS30100	COG0746	molybdenum cofactor guanylyltransferase activity
LZ559_RS30110	COG2197	response regulator
LZ559_RS30130	COG1414	Transcriptional regulator
LZ559_RS30135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LZ559_RS30140	COG4266	Belongs to the allantoicase family
LZ559_RS30145	COG0656	L-ascorbic acid biosynthetic process
LZ559_RS30150	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS30175	COG2197	response regulator
LZ559_RS30190	COG0673	inositol 2-dehydrogenase activity
LZ559_RS30195	COG2188	Transcriptional regulator
LZ559_RS30200	COG1879	ABC-type sugar transport system periplasmic component
LZ559_RS30210	COG1129	ABC transporter
LZ559_RS30215	COG1940	carbohydrate kinase activity
LZ559_RS30225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ559_RS30230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LZ559_RS30245	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS30255	COG1126	abc transporter atp-binding protein
LZ559_RS30260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ559_RS30265	COG0765	amino acid transport
LZ559_RS30270	COG0765	amino acid transport
LZ559_RS30295	COG0405	Gamma-glutamyltransferase
LZ559_RS30330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZ559_RS30335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LZ559_RS30345	COG1953	Uracil, thiamine, allantoin
LZ559_RS30365	COG1191	sigma factor activity
LZ559_RS30375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LZ559_RS30385	COG2205	protein histidine kinase activity
LZ559_RS30390	COG2838	Isocitrate dehydrogenase
LZ559_RS30410	COG0095	Lipoate-protein ligase
LZ559_RS30430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LZ559_RS30480	COG2233	PERMEase
LZ559_RS30510	COG0483	inositol monophosphate 1-phosphatase activity
LZ559_RS30530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LZ559_RS30565	COG2072	flavoprotein involved in K transport
LZ559_RS30570	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS30585	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS30620	COG1929	Belongs to the glycerate kinase type-1 family
LZ559_RS30640	COG0559	Belongs to the binding-protein-dependent transport system permease family
LZ559_RS30670	COG0688	phosphatidylethanolamine metabolic process
LZ559_RS30675	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS30685	COG2301	Belongs to the HpcH HpaI aldolase family
LZ559_RS30690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LZ559_RS30690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LZ559_RS30695	COG0604	alcohol dehydrogenase
LZ559_RS30710	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ559_RS30725	COG0596	Alpha beta hydrolase
LZ559_RS30750	COG0583	DNA-binding transcription factor activity
LZ559_RS30755	COG0667	Aldo Keto reductase
LZ559_RS30775	COG2362	D-Aminopeptidase
LZ559_RS30780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LZ559_RS30790	COG1619	proteins homologs of microcin C7 resistance protein MccF
LZ559_RS30810	COG0457	Tetratricopeptide repeat
LZ559_RS30865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LZ559_RS30880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LZ559_RS30880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LZ559_RS30890	COG2154	pterin-4-alpha-carbinolamine dehydratase
LZ559_RS30900	COG0702	epimerase
LZ559_RS30910	COG4106	trans-aconitate 2-methyltransferase activity
LZ559_RS30920	COG0656	L-ascorbic acid biosynthetic process
LZ559_RS30945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LZ559_RS30950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ559_RS30960	COG1129	ABC transporter
LZ559_RS30965	COG1172	Belongs to the binding-protein-dependent transport system permease family
LZ559_RS30970	COG1879	ABC-type sugar transport system periplasmic component
LZ559_RS30975	COG0673	inositol 2-dehydrogenase activity
LZ559_RS30995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LZ559_RS31050	COG1129	ABC transporter
LZ559_RS31060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ559_RS31065	COG1869	D-ribose catabolic process
LZ559_RS31075	COG2205	protein histidine kinase activity
LZ559_RS31080	COG0745	RESPONSE REGULATOR receiver
LZ559_RS31095	COG1376	ErfK ybiS ycfS ynhG family protein
LZ559_RS31105	COG0714	Associated with various cellular activities
LZ559_RS31120	COG3629	intracellular signal transduction
LZ559_RS31120	COG3903	Transcriptional regulator
LZ559_RS31130	COG3568	Endonuclease Exonuclease Phosphatase
LZ559_RS31145	COG5002	protein histidine kinase activity
LZ559_RS31170	COG2255	four-way junction helicase activity
LZ559_RS31200	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS31210	COG0517	IMP dehydrogenase activity
LZ559_RS31210	COG4175	Glycine betaine
LZ559_RS31215	COG4176	ABC-type proline glycine betaine transport system permease component
LZ559_RS31240	COG2985	domain, Protein
LZ559_RS31240	COG0569	domain protein
LZ559_RS31270	COG1940	carbohydrate kinase activity
LZ559_RS31295	COG1846	Transcriptional regulator
LZ559_RS31320	COG2124	cytochrome p450
LZ559_RS31325	COG1486	melibiose metabolic process
LZ559_RS31355	COG3012	SEC-C Motif Domain Protein
LZ559_RS31385	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS31430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LZ559_RS31455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LZ559_RS31495	COG2326	polyphosphate kinase activity
LZ559_RS31500	COG1793	dna ligase
LZ559_RS31555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LZ559_RS31560	COG0488	(ABC) transporter
LZ559_RS31590	COG1515	deoxyribonuclease V activity
LZ559_RS31605	COG3268	Saccharopine dehydrogenase
LZ559_RS31610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LZ559_RS31615	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS31620	COG0183	Belongs to the thiolase family
LZ559_RS31625	COG1024	Enoyl-CoA hydratase
LZ559_RS31625	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ559_RS31630	COG0789	Transcriptional regulator
LZ559_RS31655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LZ559_RS31675	COG0488	(ABC) transporter
LZ559_RS31695	COG4977	sequence-specific DNA binding
LZ559_RS31705	COG1024	Enoyl-CoA hydratase
LZ559_RS31720	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LZ559_RS31750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LZ559_RS31770	COG1388	LysM domain
LZ559_RS31770	COG1134	teichoic acid transport
LZ559_RS31775	COG1562	ergosterol biosynthetic process
LZ559_RS31785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LZ559_RS31795	COG1657	PFAM Prenyltransferase squalene oxidase
LZ559_RS31885	COG3467	pyridoxamine 5'-phosphate
LZ559_RS31895	COG0789	Transcriptional regulator
LZ559_RS31950	COG1609	Transcriptional regulator
LZ559_RS31955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LZ559_RS31965	COG1116	anion transmembrane transporter activity
LZ559_RS31980	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ559_RS31990	COG3958	Transketolase
LZ559_RS32020	COG3511	phospholipase C
LZ559_RS32030	COG2197	response regulator
LZ559_RS32035	COG3851	Histidine kinase
LZ559_RS32045	COG2186	Transcriptional regulator
LZ559_RS32050	COG0247	lactate metabolic process
LZ559_RS32055	COG1139	Iron-sulfur cluster binding protein
LZ559_RS32060	COG1556	Lactate utilization protein
LZ559_RS32090	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS32100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LZ559_RS32110	COG1953	Uracil, thiamine, allantoin
LZ559_RS32125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LZ559_RS32160	COG0446	pyridine nucleotide-disulphide oxidoreductase
LZ559_RS32160	COG1902	pentaerythritol trinitrate reductase activity
LZ559_RS32175	COG2409	Drug exporters of the RND superfamily
LZ559_RS32180	COG1846	Transcriptional regulator
LZ559_RS32225	COG1233	COG1233 Phytoene dehydrogenase and related
LZ559_RS32230	COG2130	NADP-dependent
LZ559_RS32240	COG4948	Mandelate Racemase Muconate Lactonizing
LZ559_RS32245	COG0395	ABC-type sugar transport system, permease component
LZ559_RS32250	COG1175	transmembrane transport
LZ559_RS32260	COG2188	Transcriptional regulator
LZ559_RS32300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZ559_RS32310	COG1733	regulation of RNA biosynthetic process
LZ559_RS32335	COG4221	oxidoreductase activity
LZ559_RS32340	COG2226	methyltransferase
LZ559_RS32370	COG0604	alcohol dehydrogenase
LZ559_RS32370	COG3321	synthase
LZ559_RS32410	COG0515	serine threonine protein kinase
LZ559_RS32410	COG2815	serine threonine protein kinase
LZ559_RS32415	COG0515	serine threonine protein kinase
LZ559_RS32420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LZ559_RS32500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LZ559_RS32500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LZ559_RS32535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LZ559_RS32545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LZ559_RS32550	COG0019	diaminopimelate decarboxylase activity
LZ559_RS32560	COG2837	iron assimilation
LZ559_RS32565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LZ559_RS32585	COG1119	ATPase activity
LZ559_RS32620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LZ559_RS32630	COG0395	ABC-type sugar transport system, permease component
LZ559_RS32635	COG1175	transmembrane transport
LZ559_RS32645	COG1940	carbohydrate kinase activity
LZ559_RS32705	COG0784	Response regulator, receiver
LZ559_RS32710	COG4251	negative regulation of phosphorylation
LZ559_RS32715	COG2201	protein-glutamate methylesterase activity
LZ559_RS32720	COG1191	sigma factor activity
LZ559_RS32770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LZ559_RS32790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ559_RS32795	COG3275	phosphorelay sensor kinase activity
LZ559_RS32865	COG0583	DNA-binding transcription factor activity
LZ559_RS32875	COG1053	succinate dehydrogenase
LZ559_RS32880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LZ559_RS32890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS32900	COG3360	Dodecin
LZ559_RS32905	COG2182	Extracellular solute-binding protein
LZ559_RS32920	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LZ559_RS32925	COG0121	glutamine amidotransferase
LZ559_RS32930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ559_RS32950	COG1609	Transcriptional regulator
LZ559_RS32960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ559_RS32965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZ559_RS32970	COG0539	negative regulation of cytoplasmic translation
LZ559_RS32975	COG0297	glycogen (starch) synthase activity
LZ559_RS32980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LZ559_RS32985	COG0477	Major facilitator Superfamily
LZ559_RS33010	COG0714	Associated with various cellular activities
LZ559_RS33015	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LZ559_RS33040	COG1357	PFAM Pentapeptide repeats (8 copies)
LZ559_RS33050	COG2045	Belongs to the ComB family
LZ559_RS33075	COG1834	amidinotransferase
LZ559_RS33085	COG1228	amidohydrolase
LZ559_RS33110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LZ559_RS33135	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS33165	COG0587	DNA-directed DNA polymerase activity
LZ559_RS33170	COG0640	Transcriptional regulator
LZ559_RS33185	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LZ559_RS33210	COG1024	Enoyl-CoA hydratase
LZ559_RS33215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ559_RS33245	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS33250	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS33255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ559_RS33260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ559_RS33270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ559_RS33280	COG1131	(ABC) transporter
LZ559_RS33285	COG1024	Enoyl-CoA hydratase
LZ559_RS33300	COG0657	acetylesterase activity
LZ559_RS33325	COG1233	COG1233 Phytoene dehydrogenase and related
LZ559_RS33355	COG1609	Transcriptional regulator
LZ559_RS33370	COG1172	Belongs to the binding-protein-dependent transport system permease family
LZ559_RS33375	COG1129	ABC transporter
LZ559_RS33380	COG4952	isomerase
LZ559_RS33385	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS33385	COG3347	Dehydrogenase
LZ559_RS33390	COG1070	Carbohydrate kinase
LZ559_RS33395	COG3250	beta-galactosidase activity
LZ559_RS33410	COG1120	ATPase activity
LZ559_RS33420	COG0477	Major facilitator Superfamily
LZ559_RS33425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LZ559_RS33435	COG0254	rRNA binding
LZ559_RS33440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LZ559_RS33445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LZ559_RS33450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LZ559_RS33465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS33470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS33475	COG1120	ATPase activity
LZ559_RS33505	COG1132	(ABC) transporter
LZ559_RS33530	COG2304	oxidoreductase activity
LZ559_RS33550	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS33555	COG0726	polysaccharide deacetylase
LZ559_RS33575	COG0438	transferase activity, transferring glycosyl groups
LZ559_RS33615	COG0656	L-ascorbic acid biosynthetic process
LZ559_RS33625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LZ559_RS33645	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS33650	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS33655	COG2188	Transcriptional regulator
LZ559_RS33670	COG1175	transmembrane transport
LZ559_RS33675	COG0395	ABC-type sugar transport system, permease component
LZ559_RS33685	COG0601	transmembrane transport
LZ559_RS33690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LZ559_RS33695	COG0444	Belongs to the ABC transporter superfamily
LZ559_RS33780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LZ559_RS33780	COG1796	DNA polymerase
LZ559_RS33820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LZ559_RS33885	COG1278	Cold shock
LZ559_RS33900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LZ559_RS33905	COG0693	protein deglycase activity
LZ559_RS33915	COG2375	cellular response to nickel ion
LZ559_RS33925	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LZ559_RS33945	COG1063	alcohol dehydrogenase
LZ559_RS33980	COG0789	Transcriptional regulator
LZ559_RS33985	COG1960	acyl-CoA dehydrogenase activity
LZ559_RS33995	COG1408	metallophosphoesterase
LZ559_RS34010	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LZ559_RS34010	COG1672	PFAM Archaeal ATPase
LZ559_RS34035	COG1794	racemase activity, acting on amino acids and derivatives
LZ559_RS34055	COG0326	Molecular chaperone. Has ATPase activity
LZ559_RS34110	COG1012	belongs to the aldehyde dehydrogenase family
LZ559_RS34130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LZ559_RS34135	COG3239	Fatty acid desaturase
LZ559_RS34165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LZ559_RS34170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LZ559_RS34175	COG0640	Transcriptional regulator
LZ559_RS34190	COG2018	Roadblock/LC7 domain
LZ559_RS34220	COG1024	Enoyl-CoA hydratase
LZ559_RS34240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZ559_RS34245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LZ559_RS34260	COG2340	Cysteine-rich secretory protein family
LZ559_RS34295	COG0583	DNA-binding transcription factor activity
LZ559_RS34315	COG0488	(ABC) transporter
LZ559_RS34335	COG0009	L-threonylcarbamoyladenylate synthase
LZ559_RS34390	COG2318	DinB family
LZ559_RS34420	COG0395	ABC-type sugar transport system, permease component
LZ559_RS34425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LZ559_RS34430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LZ559_RS34440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZ559_RS34445	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS34455	COG0714	Associated with various cellular activities
LZ559_RS34460	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LZ559_RS34500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ559_RS34505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LZ559_RS34520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LZ559_RS34565	COG0586	Pfam SNARE associated Golgi protein
LZ559_RS34580	COG2226	methyltransferase
LZ559_RS34595	COG1874	Beta-galactosidase
LZ559_RS34600	COG1609	Transcriptional regulator
LZ559_RS34605	COG0395	ABC-type sugar transport system, permease component
LZ559_RS34610	COG1175	transmembrane transport
LZ559_RS34615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LZ559_RS34630	COG1595	DNA-templated transcription, initiation
LZ559_RS34645	COG4214	carbohydrate transport
LZ559_RS34655	COG4213	ABC transporter substrate-binding protein
LZ559_RS34665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZ559_RS34680	COG1070	Carbohydrate kinase
LZ559_RS34700	COG1404	Belongs to the peptidase S8 family
LZ559_RS34740	COG0028	Belongs to the TPP enzyme family
LZ559_RS34745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ559_RS34755	COG2267	carboxylic ester hydrolase activity
LZ559_RS34785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ559_RS34795	COG2066	Belongs to the glutaminase family
LZ559_RS34865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LZ559_RS34920	COG0596	Alpha beta hydrolase
LZ559_RS35005	COG1028	Short-chain dehydrogenase reductase Sdr
LZ559_RS35015	COG1397	ADP-ribosylglycohydrolase
LZ559_RS35055	COG3547	Transposase (IS116 IS110 IS902 family)
LZ559_RS35085	COG0515	serine threonine protein kinase
LZ559_RS35085	COG2815	serine threonine protein kinase
LZ559_RS35160	COG2382	esterase
LZ559_RS35160	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ559_RS35160	COG3693	PFAM glycoside hydrolase, family 10
LZ559_RS35170	COG0477	Major facilitator Superfamily
LZ559_RS35270	COG3209	COG3209 Rhs family protein