locus-tag class description HEP84_RS00045 ENOG4105DBI uridine monophosphokinase HEP84_RS00050 ENOG4105DBI uridine monophosphokinase HEP84_RS00110 ENOG4105CHP RNA polymerase HEP84_RS00140 ENOG4105ECQ AraC Family Transcriptional Regulator HEP84_RS00220 ENOG4105VEQ Cold shock protein HEP84_RS00240 ENOG4108HMN Caspase domain HEP84_RS00355 ENOG4105VNT transposase (IS4 family) protein HEP84_RS00435 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS00505 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HEP84_RS00525 ENOG4106KE4 Dehydrogenase HEP84_RS00555 ENOG4108BAS reductase HEP84_RS00570 ENOG4105VNT transposase (IS4 family) protein HEP84_RS00595 ENOG4107GJV short-chain dehydrogenase reductase HEP84_RS00615 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEP84_RS00615 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEP84_RS00660 ENOG4105ECP epimerase HEP84_RS00665 ENOG4108KPJ rna polymerase sigma factor HEP84_RS00695 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HEP84_RS00705 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS00730 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP84_RS00760 ENOG4108MP6 LysR family Transcriptional regulator HEP84_RS00785 ENOG4105I1F Resistance protein HEP84_RS00815 ENOG4105RKW reductase (By HEP84_RS00850 ENOG4105EV9 Alpha Beta Hydrolase HEP84_RS00855 ENOG4105CVJ phosphoglycerate mutase HEP84_RS00860 ENOG4105EJ2 Transcriptional regulator HEP84_RS00865 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP84_RS00885 ENOG4105EKQ RNA-directed DNA polymerase HEP84_RS00980 ENOG4105CBC glutamate synthase HEP84_RS00990 ENOG4107R6F Alpha Beta Hydrolase Fold protein HEP84_RS01000 ENOG4105WN5 stage II sporulation protein HEP84_RS01015 ENOG4105CJ1 ABC, transporter HEP84_RS01020 ENOG4105BZU Histidine kinase HEP84_RS01025 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS01060 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HEP84_RS01070 ENOG4105Q33 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency HEP84_RS01185 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HEP84_RS01190 ENOG4105JAB phenazine biosynthesis protein, phzf family HEP84_RS01200 ENOG4105EW9 transcriptional regulator AsnC family HEP84_RS01205 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP84_RS01255 ENOG4105JAB phenazine biosynthesis protein, phzf family HEP84_RS01305 ENOG4105EHZ conserved protein UCP016719 HEP84_RS01335 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS01345 ENOG4105ECQ AraC Family Transcriptional Regulator HEP84_RS01360 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEP84_RS01375 ENOG41082JN Transcriptional regulator HEP84_RS01380 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP84_RS01390 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS01400 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS01405 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS01415 ENOG4107SET aldo keto reductase HEP84_RS01420 ENOG4105CY0 Metallo-Beta-Lactamase HEP84_RS01480 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP84_RS01495 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HEP84_RS01510 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HEP84_RS01530 ENOG4105CHR reductase HEP84_RS01580 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HEP84_RS01605 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HEP84_RS01635 ENOG4105C26 Dehydrogenase HEP84_RS01650 ENOG4105VUF Transcriptional regulator HEP84_RS01665 ENOG4105CMT Dihydroxyacetone kinase HEP84_RS01675 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HEP84_RS01700 ENOG4105FF0 ErfK YbiS YcfS YnhG HEP84_RS01715 ENOG4107S5I aldo keto reductase HEP84_RS01730 ENOG4107VFM Dehydrogenase HEP84_RS01755 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS01765 ENOG4105D7V transposase HEP84_RS01870 ENOG4107QN1 sodium solute HEP84_RS01890 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP84_RS01895 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP84_RS01975 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEP84_RS01980 ENOG4107QRI Phosphoketolase HEP84_RS02005 ENOG4108YV4 Universal stress protein HEP84_RS02025 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEP84_RS02030 ENOG4105EPW hflc protein HEP84_RS02045 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEP84_RS02055 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS02090 ENOG4105VU5 Resolvase domain-containing protein HEP84_RS02100 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HEP84_RS02115 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS02120 ENOG4108R85 Short chain dehydrogenase HEP84_RS02125 ENOG4105FDP GntR family transcriptional regulator HEP84_RS02145 ENOG4105E2D ec 3.2.1.52 HEP84_RS02150 ENOG4105D7V transposase HEP84_RS02245 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS02255 ENOG4107QNK )-transporter HEP84_RS02260 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP84_RS02265 ENOG4105F0H myo-inositol catabolism protein HEP84_RS02275 ENOG4105ESN nucleotide-binding protein HEP84_RS02285 ENOG4108PA7 Methyltransferase HEP84_RS02315 ENOG4106UDK Cellulose-binding, family II HEP84_RS02375 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP84_RS02380 ENOG4105CHR reductase HEP84_RS02390 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP84_RS02430 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS02570 ENOG4105ETS cytosine purines uracil thiamine allantoin HEP84_RS02590 ENOG4105E2A Dehydrogenase HEP84_RS02600 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS02605 ENOG4105DDV Transcriptional regulator (LacI family HEP84_RS02620 ENOG4105CNN ABC, transporter HEP84_RS02625 ENOG4105C2J ABC transporter HEP84_RS02630 ENOG4105F0H myo-inositol catabolism protein HEP84_RS02645 ENOG4105DH8 myo-inositol catabolism HEP84_RS02650 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP84_RS02655 ENOG4105C26 Dehydrogenase HEP84_RS02665 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HEP84_RS02700 ENOG4105JQZ Methyltransferase HEP84_RS02735 ENOG4105DFW ABC transporter HEP84_RS02745 ENOG4105DFW ABC transporter HEP84_RS02750 ENOG4105C2J ABC transporter HEP84_RS02755 ENOG4108HWW ABC transporter HEP84_RS02765 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP84_RS02770 ENOG4108K8U Glycerol operon regulatory protein HEP84_RS02790 ENOG4105C0W non-ribosomal peptide synthetase HEP84_RS02805 ENOG4107YCR Transcriptional regulator, ARSR family HEP84_RS02810 ENOG4108UXE Protein tyrosine phosphatase HEP84_RS02815 ENOG4107R33 ppx gppa phosphatase HEP84_RS02830 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS02880 ENOG4105EHG Permease protein HEP84_RS02885 ENOG4105E0A ABC, transporter HEP84_RS02935 ENOG4108IAJ Nad-dependent epimerase dehydratase HEP84_RS02965 ENOG4105D7V transposase HEP84_RS02990 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS02995 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HEP84_RS03035 ENOG4107SM8 Adenylate Guanylate cyclase HEP84_RS03080 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS03085 ENOG410800I Aminomethyltransferase HEP84_RS03090 ENOG4105C4K Nad synthetase HEP84_RS03090 ENOG4105C4K Nad synthetase HEP84_RS03095 ENOG4105DAE Methylenetetrahydrofolate reductase HEP84_RS03105 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEP84_RS03115 ENOG4105DQ4 alcohol dehydrogenase HEP84_RS03145 ENOG4107RTD sua5 ycio yrdc ywlc family protein HEP84_RS03155 ENOG4105CFG Acts as a chaperone (By similarity) HEP84_RS03160 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP84_RS03175 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP84_RS03190 ENOG4107HP6 Transcriptional regulator HEP84_RS03195 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HEP84_RS03200 ENOG4105C6Z Gluconate HEP84_RS03205 ENOG4105EQX glucarate dehydratase HEP84_RS03220 ENOG4105C19 ABC transporter HEP84_RS03225 ENOG4105BZU Histidine kinase HEP84_RS03230 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS03235 ENOG4105J7D transcriptional regulator HEP84_RS03240 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP84_RS03250 ENOG4108KPJ rna polymerase sigma factor HEP84_RS03260 ENOG4108ME1 Peptidase M55 D-aminopeptidase HEP84_RS03285 ENOG4105D2S major facilitator superfamily HEP84_RS03300 ENOG4105JSC dimethylmenaquinone methyltransferase HEP84_RS03310 ENOG4108QBF Transcriptional regulator HEP84_RS03325 ENOG4105EQ2 LysR family Transcriptional regulator HEP84_RS03330 ENOG4107AQZ Membrane HEP84_RS03345 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP84_RS03590 ENOG4105PW4 Sugar fermentation stimulation protein homolog HEP84_RS03630 ENOG4105CGS Alpha-glucosidase HEP84_RS03670 ENOG4105CR4 methylisocitrate lyase HEP84_RS03690 ENOG4105D7V transposase HEP84_RS03745 ENOG4105F2M alpha beta hydrolase fold-3 domain protein HEP84_RS03780 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEP84_RS03785 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEP84_RS03805 ENOG4105DMF Dehydrogenase HEP84_RS03815 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS03820 ENOG4108XG4 DNA-binding transcriptional regulator HEP84_RS03855 ENOG4108V1U phospholipid-binding protein HEP84_RS03870 ENOG4105CHR reductase HEP84_RS03875 ENOG4107YCY Transcriptional regulator HEP84_RS03880 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS03890 ENOG4105CC9 acyl-Coa dehydrogenase HEP84_RS03905 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS03915 ENOG4105CGU Enoyl-CoA hydratase HEP84_RS03920 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS03925 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS03930 ENOG4105CHR reductase HEP84_RS03945 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS03950 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS03965 ENOG4108IV0 ABC, transporter HEP84_RS03970 ENOG4105C0Z ABC transporter HEP84_RS03990 ENOG4105CC9 acyl-Coa dehydrogenase HEP84_RS03995 ENOG4105D2B acyl-CoA dehydrogenase HEP84_RS04010 ENOG4105EBR Carboxylesterase HEP84_RS04015 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS04030 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS04035 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04055 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP84_RS04070 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04080 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04090 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS04100 ENOG4108RZE Tetr family transcriptional regulator HEP84_RS04105 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP84_RS04140 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP84_RS04145 ENOG4105C26 Dehydrogenase HEP84_RS04160 ENOG4105CHR reductase HEP84_RS04170 ENOG4105DVW rieske (2Fe-2S) HEP84_RS04190 ENOG4105CC9 acyl-Coa dehydrogenase HEP84_RS04210 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS04240 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HEP84_RS04250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS04260 ENOG4108RZE Tetr family transcriptional regulator HEP84_RS04265 ENOG4105BZU Histidine kinase HEP84_RS04270 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS04280 ENOG4105EQ0 Major Facilitator superfamily HEP84_RS04360 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HEP84_RS04370 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HEP84_RS04375 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HEP84_RS04405 ENOG4105E8G Major facilitator Superfamily HEP84_RS04430 ENOG4107VIJ nudix hydrolase HEP84_RS04440 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS04450 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS04455 ENOG4105EGE secreted protein HEP84_RS04470 ENOG4105EX0 alpha-galactosidase HEP84_RS04480 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP84_RS04490 ENOG4105E2R ROK family HEP84_RS04545 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04575 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04580 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04585 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04590 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04595 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04610 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04615 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04620 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04625 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS04665 ENOG4105BZ1 (ABC) transporter HEP84_RS04690 ENOG4105BZU Histidine kinase HEP84_RS04695 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS04745 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS04760 ENOG4105ENE Histidine kinase HEP84_RS04770 ENOG4105E98 transcriptional regulator DeoR family HEP84_RS04775 ENOG4106UW1 Major Facilitator superfamily HEP84_RS04805 ENOG4105C0A alcohol dehydrogenase HEP84_RS04810 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP84_RS04840 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEP84_RS04895 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) HEP84_RS04970 ENOG4107SHJ sulfite reductase subunit b HEP84_RS05005 ENOG4108XXK NUDIX hydrolase HEP84_RS05030 ENOG4105EKQ RNA-directed DNA polymerase HEP84_RS05035 ENOG4105D7V transposase HEP84_RS05080 ENOG4105ENX hydrolase HEP84_RS05110 ENOG4105CPQ Dehydrogenase HEP84_RS05115 ENOG4105D7K pfkb domain protein HEP84_RS05120 ENOG4105EKQ RNA-directed DNA polymerase HEP84_RS05145 ENOG4108YYH Nadph-dependent fmn reductase HEP84_RS05200 ENOG4105D7V transposase HEP84_RS05335 ENOG4105ETX regulatoR HEP84_RS05355 ENOG41063TF transcriptional regulator (AraC HEP84_RS05365 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP84_RS05395 ENOG4105ECQ AraC Family Transcriptional Regulator HEP84_RS05465 ENOG4105EMU Dehydrogenase HEP84_RS05470 ENOG4106NZI LysR family Transcriptional regulator HEP84_RS05525 ENOG4105CH2 amidohydrolase HEP84_RS05530 ENOG4107ZT3 family UPF0126 HEP84_RS05560 ENOG4107R13 MMPL domain protein HEP84_RS05570 ENOG4105EMU Dehydrogenase HEP84_RS05575 ENOG4105C26 Dehydrogenase HEP84_RS05625 ENOG4105CPF Cell wall formation (By similarity) HEP84_RS05650 ENOG4108RWI nicotinamidase HEP84_RS05695 ENOG4105VTR Integrase HEP84_RS05725 ENOG4105CHR reductase HEP84_RS05760 ENOG4105EV8 ectoine hydroxylase HEP84_RS05775 ENOG4105CPC Aldo Keto reductase HEP84_RS05780 ENOG4105VUF Transcriptional regulator HEP84_RS05815 ENOG4108C33 Resolvase HEP84_RS05820 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEP84_RS05850 ENOG4105QBC HEP84_RS05885 ENOG4107SVN transposase HEP84_RS05895 ENOG4108KPJ rna polymerase sigma factor HEP84_RS05900 ENOG4105C57 major facilitator superfamily HEP84_RS05925 ENOG410836F Transposase HEP84_RS05975 ENOG4108YYC ycei family HEP84_RS05990 ENOG4105KF0 sporulation and cell division protein, SsgA HEP84_RS06195 ENOG4108JSS Haloalkane dehalogenase HEP84_RS06200 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP84_RS06285 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP84_RS06355 ENOG4105BZU Histidine kinase HEP84_RS06360 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS06365 ENOG4105D5G Transposase HEP84_RS06490 ENOG4108KEZ Dehydrogenase HEP84_RS06545 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HEP84_RS06575 ENOG4108M8W Monooxygenase HEP84_RS06625 ENOG4105MSB protein, conserved in bacteria HEP84_RS06690 ENOG4105ECY inositol monophosphatase HEP84_RS06695 ENOG4105G2Y Transcriptional regulator HEP84_RS06765 ENOG4105KVH Transcriptional regulator HEP84_RS06785 ENOG4105CWX Alpha-1,2-mannosidase HEP84_RS06795 ENOG4105DYW oxidoreductase HEP84_RS06815 ENOG4105CIR epoxide hydrolase HEP84_RS06820 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP84_RS06825 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP84_RS06855 ENOG4105BZU Histidine kinase HEP84_RS06920 ENOG4105IDI abc transporter atp-binding protein HEP84_RS06940 ENOG4105E7U AraC family transcriptional regulator HEP84_RS06950 ENOG4105CPC Aldo Keto reductase HEP84_RS06955 ENOG4108M0I Transcriptional regulator HEP84_RS06970 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP84_RS06975 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HEP84_RS06985 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP84_RS07000 ENOG4107S5I aldo keto reductase HEP84_RS07010 ENOG4105C26 Dehydrogenase HEP84_RS07030 ENOG4105C32 Amino acid ABC transporter (Permease) HEP84_RS07045 ENOG4108IV0 ABC, transporter HEP84_RS07050 ENOG4105CHP RNA polymerase HEP84_RS07065 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HEP84_RS07080 ENOG4105FBW Monooxygenase HEP84_RS07100 ENOG4105CGD Nad-dependent epimerase dehydratase HEP84_RS07105 ENOG4105CVP deoxyribo-dipyrimidine photolyase HEP84_RS07200 ENOG4107QTZ amino acid HEP84_RS07205 ENOG4105DKQ ROK family HEP84_RS07230 ENOG4105EX0 alpha-galactosidase HEP84_RS07235 ENOG4105C5X domain protein HEP84_RS07255 ENOG4105CPC Aldo Keto reductase HEP84_RS07285 ENOG4105CAQ asparagine synthetase HEP84_RS07290 ENOG4105CBC glutamate synthase HEP84_RS07295 ENOG4105CEU Arginine dihydrolase HEP84_RS07300 ENOG4105D5Q Arginine ornithine antiporter HEP84_RS07310 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP84_RS07365 ENOG4107SM8 Adenylate Guanylate cyclase HEP84_RS07405 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS07420 ENOG4105D7V transposase HEP84_RS07460 ENOG4107T6F Xaa-Pro aminopeptidase HEP84_RS07465 ENOG4105KXC Collagenase HEP84_RS07470 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HEP84_RS07495 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP84_RS07500 ENOG4108M0I Transcriptional regulator HEP84_RS07525 ENOG4105KVH Transcriptional regulator HEP84_RS07550 ENOG4107SCA Formamidase (EC 3.5.1.49) HEP84_RS07555 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HEP84_RS07575 ENOG4105CQB FAD linked oxidase domain protein HEP84_RS07585 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component HEP84_RS07595 ENOG4105DZC cytosine deaminase HEP84_RS07600 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HEP84_RS07605 ENOG4105MXW flavin reductase domain protein, FMN-binding HEP84_RS07650 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS07665 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP84_RS07690 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP84_RS07710 ENOG4105ERH Fumarylacetoacetate hydrolase HEP84_RS07725 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEP84_RS07765 ENOG4105ECR NmrA family HEP84_RS07770 ENOG4105CPQ Dehydrogenase HEP84_RS07780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS07790 ENOG4108IG5 Transcriptional regulator HEP84_RS07805 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS07820 ENOG4105EMU Dehydrogenase HEP84_RS07830 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP84_RS07835 ENOG4105CHR reductase HEP84_RS07895 ENOG4105X7H acyl-CoA dehydrogenase HEP84_RS07930 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS07935 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP84_RS07940 ENOG4105D7V transposase HEP84_RS07955 ENOG4105C26 Dehydrogenase HEP84_RS07960 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP84_RS07965 ENOG4105DH8 myo-inositol catabolism HEP84_RS07975 ENOG4105EDK PfkB domain protein HEP84_RS07985 ENOG4105CNN ABC, transporter HEP84_RS07990 ENOG4105C2J ABC transporter HEP84_RS08015 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP84_RS08020 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS08030 ENOG4105CPQ Dehydrogenase HEP84_RS08040 ENOG4105D3W isochorismatase HEP84_RS08055 ENOG4105CT3 Monooxygenase HEP84_RS08070 ENOG410836F Transposase HEP84_RS08085 ENOG4105DRR Transcriptional regulator, GntR family HEP84_RS08100 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HEP84_RS08105 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP84_RS08110 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP84_RS08120 ENOG4105C0X amino acid HEP84_RS08160 ENOG4108W5M transcriptional regulator HEP84_RS08245 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEP84_RS08260 ENOG4105C0B DNA polymerase III (alpha subunit) HEP84_RS08400 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP84_RS08415 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEP84_RS08475 ENOG410905P Pyridoxamine 5-phosphate HEP84_RS08495 ENOG41082YX Transcriptional regulator, arsr family HEP84_RS08510 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP84_RS08525 ENOG4108UXE Protein tyrosine phosphatase HEP84_RS08565 ENOG4105EMU Dehydrogenase HEP84_RS08570 ENOG4105CHJ isochorismatase hydrolase HEP84_RS08610 ENOG4105CMT Dihydroxyacetone kinase HEP84_RS08615 ENOG4108UTZ Dihydroxyacetone kinase HEP84_RS08630 ENOG4105CHR reductase HEP84_RS08640 ENOG4105CYP glycoside hydrolase, family HEP84_RS08660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP84_RS08665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP84_RS08710 ENOG4105I82 acetyl xylan esterase HEP84_RS08725 ENOG4105FDP GntR family transcriptional regulator HEP84_RS08735 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS08740 ENOG4105CG3 alpha amylase, catalytic region HEP84_RS08745 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP84_RS08800 ENOG4105ERH Fumarylacetoacetate hydrolase HEP84_RS08825 ENOG4105GRZ Ycii-related protein HEP84_RS08835 ENOG4108UYE Lactoylglutathione lyase HEP84_RS08840 ENOG4105CHR reductase HEP84_RS08870 ENOG4105CSV Glutaminase HEP84_RS08875 ENOG4108IJ0 Aspartate ammonia-lyase HEP84_RS08895 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP84_RS08905 ENOG4105KJJ Uncharacterized ACR, COG1993 HEP84_RS08910 ENOG41083YR Protein CrcB homolog HEP84_RS08940 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS08955 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HEP84_RS08985 ENOG4105EDW glycosyl transferase, family 39 HEP84_RS09020 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HEP84_RS09025 ENOG4107RRZ synthase HEP84_RS09040 ENOG4105QVC MOSC domain-containing protein HEP84_RS09060 ENOG4105MVE transcriptional regulator HEP84_RS09085 ENOG4107R34 abc transporter permease protein HEP84_RS09090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS09125 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HEP84_RS09145 ENOG4105D2N Aldolase HEP84_RS09150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP84_RS09155 ENOG4105E98 transcriptional regulator DeoR family HEP84_RS09160 ENOG4105CWX Alpha-1,2-mannosidase HEP84_RS09165 ENOG4108IJ8 ABC transporter HEP84_RS09170 ENOG4105E90 ABC transporter HEP84_RS09190 ENOG4105GWZ Roadblock lc7 family protein HEP84_RS09210 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP84_RS09220 ENOG4107P5I polyketide synthase HEP84_RS09240 ENOG4108VQT Alpha beta hydrolase fold protein HEP84_RS09245 ENOG4108MRH transcriptional regulatory protein HEP84_RS09250 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEP84_RS09255 ENOG4105D7T ABC transporter HEP84_RS09260 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HEP84_RS09290 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEP84_RS09295 ENOG4105C4M (Ubiquinol oxidase) subunit I HEP84_RS09305 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEP84_RS09350 ENOG4105BZP glycoside hydrolase 15-related HEP84_RS09365 ENOG4106UW1 Major Facilitator superfamily HEP84_RS09390 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS09395 ENOG4105BZU Histidine kinase HEP84_RS09410 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HEP84_RS09415 ENOG4107PP3 Acetylornithine deacetylase HEP84_RS09420 ENOG4105I1F Resistance protein HEP84_RS09455 ENOG4105EX0 alpha-galactosidase HEP84_RS09465 ENOG41060NJ transcriptional regulator HEP84_RS09485 ENOG4105C10 Electron transfer flavoprotein HEP84_RS09510 ENOG4105PSQ Acyl-transferase HEP84_RS09535 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEP84_RS09580 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP84_RS09615 ENOG4105C2W permease HEP84_RS09620 ENOG4105YVS arsR family transcriptional regulator HEP84_RS09625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP84_RS09640 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS09645 ENOG4105BZU Histidine kinase HEP84_RS09660 ENOG4105DBE peroxidase HEP84_RS09665 ENOG410650H (LipO)protein HEP84_RS09670 ENOG4105CRK lysyL-tRNA synthetase HEP84_RS09685 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP84_RS09720 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP84_RS09755 ENOG4105EBM Alpha Beta Hydrolase Fold protein HEP84_RS09760 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEP84_RS09765 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP84_RS09770 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HEP84_RS09780 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HEP84_RS09795 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HEP84_RS09830 ENOG4105C7W Xanthine dehydrogenase HEP84_RS09840 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HEP84_RS09855 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP84_RS09885 ENOG4108RQS Two component transcriptional regulator (Winged helix family HEP84_RS09940 ENOG4105V9V Short-chain dehydrogenase reductase Sdr HEP84_RS09985 ENOG4107S5I aldo keto reductase HEP84_RS09990 ENOG4105CHR reductase HEP84_RS10020 ENOG4105C1J atp-dependent rna helicase HEP84_RS10045 ENOG4107ZED Uncharacterised protein family UPF0047 HEP84_RS10050 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP84_RS10055 ENOG4105E2Y ABC, transporter HEP84_RS10065 ENOG4105H3G oxidoreductase HEP84_RS10075 ENOG4105BZ1 (ABC) transporter HEP84_RS10105 ENOG4105BZ1 (ABC) transporter HEP84_RS10130 ENOG4105C29 acyl-CoA thioesterase HEP84_RS10145 ENOG4105GWZ Roadblock lc7 family protein HEP84_RS10175 ENOG4105BZU Histidine kinase HEP84_RS10185 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HEP84_RS10215 ENOG4105C0D helicase HEP84_RS10235 ENOG4105C93 Xylose Isomerase HEP84_RS10245 ENOG4105E2R ROK family HEP84_RS10250 ENOG4105C85 amino acid HEP84_RS10255 ENOG4107SCA Formamidase (EC 3.5.1.49) HEP84_RS10270 ENOG4105C26 Dehydrogenase HEP84_RS10280 ENOG4105J7D transcriptional regulator HEP84_RS10325 ENOG4107FKK extracellular solute-binding protein family 1 HEP84_RS10330 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS10355 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP84_RS10360 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEP84_RS10375 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component HEP84_RS10380 ENOG4108IJ7 Glycine betaine HEP84_RS10400 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HEP84_RS10410 ENOG4105DVW rieske (2Fe-2S) HEP84_RS10415 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HEP84_RS10420 ENOG4105VQD rieske 2fe-2S domain-containing protein HEP84_RS10425 ENOG4105EJQ L-serine dehydratase HEP84_RS10485 ENOG4108UGD Serine Threonine protein kinase HEP84_RS10510 ENOG4105D2B acyl-CoA dehydrogenase HEP84_RS10515 ENOG4105D2B acyl-CoA dehydrogenase HEP84_RS10520 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP84_RS10530 ENOG4105C3M thioredoxin reductase HEP84_RS10535 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HEP84_RS10545 ENOG4105C26 Dehydrogenase HEP84_RS10560 ENOG41065KQ synthase HEP84_RS10565 ENOG4106A3M Cytochrome p-450 HEP84_RS10575 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS10585 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP84_RS10595 ENOG4105F1K Glutamine amidotransferase HEP84_RS10600 ENOG4105CTQ phosphohexokinase HEP84_RS10615 ENOG4105D9P serine threonine protein kinase HEP84_RS10625 ENOG4108HRK Histidine kinase HEP84_RS10640 ENOG4108NEV two component transcriptional regulator, LytTR family HEP84_RS10650 ENOG4105CIK Amidinotransferase HEP84_RS10655 ENOG4105C8Y Acetylornithine aminotransferase HEP84_RS10665 ENOG4105KVH Transcriptional regulator HEP84_RS10680 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HEP84_RS10710 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HEP84_RS10725 ENOG4105KI2 Urea amidohydrolase subunit beta HEP84_RS10730 ENOG4108YZ9 Urea amidohydrolase subunit gamma HEP84_RS10785 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HEP84_RS10790 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP84_RS10795 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HEP84_RS10835 ENOG4105FBW Monooxygenase HEP84_RS10840 ENOG4108R6G acetyltransferase HEP84_RS10900 ENOG4105C83 adenylosuccinate lyase HEP84_RS10905 ENOG4108VCA G U mismatch-specific DNA glycosylase HEP84_RS10930 ENOG4105DKQ ROK family HEP84_RS10935 ENOG4105FDP GntR family transcriptional regulator HEP84_RS10940 ENOG4108KPJ rna polymerase sigma factor HEP84_RS10945 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HEP84_RS10955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS10990 ENOG4107RSM transcriptional regulator HEP84_RS11010 ENOG4107RFY SbcCD D subunit HEP84_RS11015 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HEP84_RS11035 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS11045 ENOG4105X7H acyl-CoA dehydrogenase HEP84_RS11065 ENOG4105K4P CoA-binding domain protein HEP84_RS11100 ENOG4105CSR polyphosphate kinase 2 HEP84_RS11105 ENOG41082SX arsR family transcriptional regulator HEP84_RS11130 ENOG4108UW5 maltose o-acetyltransferase HEP84_RS11135 ENOG4108Z0R Transferase HEP84_RS11165 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS11210 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HEP84_RS11215 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HEP84_RS11220 ENOG4108XHQ (2Fe-2S)-binding domain protein HEP84_RS11225 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HEP84_RS11330 ENOG4105CPC Aldo Keto reductase HEP84_RS11510 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEP84_RS11525 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS11550 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP84_RS11570 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP84_RS11585 ENOG4105DEN Luciferase family HEP84_RS11595 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HEP84_RS11600 ENOG4105EP9 oxidoreductase HEP84_RS11615 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HEP84_RS11620 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HEP84_RS11625 ENOG4105CHR reductase HEP84_RS11665 ENOG4108Q5Y Membrane HEP84_RS11670 ENOG4105CSW GntR family transcriptional regulator HEP84_RS11700 ENOG4105NTW Transcriptional regulator HEP84_RS11710 ENOG4105JAB phenazine biosynthesis protein, phzf family HEP84_RS11740 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HEP84_RS11750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEP84_RS11770 ENOG4108UW8 fha domain-containing protein HEP84_RS11815 ENOG4105C5Y PTS System HEP84_RS11820 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HEP84_RS11835 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS11840 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP84_RS11850 ENOG4105E09 nadh pyrophosphatase HEP84_RS11855 ENOG4108UQS dipeptidase HEP84_RS11865 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP84_RS11870 ENOG4105BZU Histidine kinase HEP84_RS11875 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP84_RS11880 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP84_RS11900 ENOG4105GWZ Roadblock lc7 family protein HEP84_RS11955 ENOG4105CFM UPF0317 protein HEP84_RS11960 ENOG4105E7W lamb ycsf family protein HEP84_RS11970 ENOG4107R7A Allophanate hydrolase subunit 2 HEP84_RS11980 ENOG4108MJN Glycosyl Transferase HEP84_RS11995 ENOG4105JXB ankyrin repeat-containing protein HEP84_RS12025 ENOG4105DEU major facilitator superfamily HEP84_RS12030 ENOG4105Q70 HEP84_RS12040 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HEP84_RS12050 ENOG4105EW9 transcriptional regulator AsnC family HEP84_RS12075 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS12085 ENOG4107Z3H Transcriptional regulator, TetR family HEP84_RS12130 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HEP84_RS12135 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HEP84_RS12140 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HEP84_RS12145 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HEP84_RS12160 ENOG4105E2R ROK family HEP84_RS12165 ENOG4106UW1 Major Facilitator superfamily HEP84_RS12180 ENOG4105C2W permease HEP84_RS12230 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HEP84_RS12235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS12245 ENOG4105F38 ABC transporter, permease HEP84_RS12255 ENOG4108TZY GntR Family Transcriptional Regulator HEP84_RS12285 ENOG4105DKT Transcriptional regulator HEP84_RS12290 ENOG4105DJV ribulose-phosphate 3-epimerase HEP84_RS12300 ENOG4107QN2 dihydrolipoyl dehydrogenase HEP84_RS12315 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HEP84_RS12330 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HEP84_RS12345 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HEP84_RS12355 ENOG4105SKN orotidine 5''-phosphate decarboxylase HEP84_RS12360 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HEP84_RS12365 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HEP84_RS12370 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HEP84_RS12380 ENOG4105CD3 dihydroorotase HEP84_RS12385 ENOG4105CXT aspartate transcarbamylase HEP84_RS12390 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HEP84_RS12400 ENOG410803B Involved in the transcription termination process (By similarity) HEP84_RS12405 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HEP84_RS12420 ENOG4105D49 3-dehydroquinate synthase HEP84_RS12425 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HEP84_RS12430 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HEP84_RS12435 ENOG4105E2X shikimate dehydrogenase HEP84_RS12440 ENOG4105HHA aminodeoxychorismate lyase HEP84_RS12445 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HEP84_RS12450 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HEP84_RS12470 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HEP84_RS12485 ENOG4105CJ1 ABC, transporter HEP84_RS12495 ENOG4105BZU Histidine kinase HEP84_RS12500 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS12505 ENOG4105CUT histidyl-tRNA synthetase HEP84_RS12515 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HEP84_RS12520 ENOG4105C99 atpase involved in dna repair HEP84_RS12525 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEP84_RS12530 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HEP84_RS12535 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEP84_RS12540 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEP84_RS12550 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEP84_RS12555 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HEP84_RS12560 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HEP84_RS12565 ENOG4105CDY transcriptional regulatory protein HEP84_RS12570 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HEP84_RS12575 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HEP84_RS12590 ENOG4105E2K Glycosyl transferase (Group 1 HEP84_RS12625 ENOG4105C22 threonyL-tRNA synthetase HEP84_RS12640 ENOG4108IRC dna polymerase iii HEP84_RS12660 ENOG4105EKC HEP84_RS12670 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HEP84_RS12675 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP84_RS12695 ENOG4105KF0 sporulation and cell division protein, SsgA HEP84_RS12725 ENOG4105F0I Aminotransferase HEP84_RS12810 ENOG4105D01 (LipO)protein HEP84_RS12815 ENOG4108UMI ABC transporter, permease HEP84_RS12820 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS12860 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS12865 ENOG4105C57 major facilitator superfamily HEP84_RS12870 ENOG4105RJZ Transcriptional regulator HEP84_RS12880 ENOG4105CH7 arginosuccinase HEP84_RS12885 ENOG4105CDH Citrulline--aspartate ligase HEP84_RS12905 ENOG4105BZU Histidine kinase HEP84_RS12910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS12915 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HEP84_RS12940 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HEP84_RS12945 ENOG4105C8Y Acetylornithine aminotransferase HEP84_RS12950 ENOG4105CAS nag kinase HEP84_RS12955 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HEP84_RS12960 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HEP84_RS12980 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP84_RS12985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP84_RS12995 ENOG4105ERH Fumarylacetoacetate hydrolase HEP84_RS13065 ENOG4105VUF Transcriptional regulator HEP84_RS13115 ENOG4105T38 integral membrane protein HEP84_RS13125 ENOG4105F32 YngK protein HEP84_RS13160 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HEP84_RS13165 ENOG4105BZU Histidine kinase HEP84_RS13170 ENOG4108RWN rrna methyltransferase HEP84_RS13175 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HEP84_RS13180 ENOG41084BS 50S ribosomal protein L35 HEP84_RS13185 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HEP84_RS13235 ENOG4105C26 Dehydrogenase HEP84_RS13240 ENOG4105C5F glutamine synthetase HEP84_RS13250 ENOG4108Z86 Glutamine amidotransferase HEP84_RS13270 ENOG4105CHR reductase HEP84_RS13275 ENOG4108YYH Nadph-dependent fmn reductase HEP84_RS13305 ENOG4108HQS Glycine betaine HEP84_RS13310 ENOG4108IJ7 Glycine betaine HEP84_RS13315 ENOG4105HFS 5'-3' exonuclease HEP84_RS13345 ENOG4105D3G Pseudouridine synthase HEP84_RS13375 ENOG4105MKU Transcriptional regulator HEP84_RS13415 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEP84_RS13420 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP84_RS13450 ENOG4108V1T peptidylprolyl cis-trans isomerase HEP84_RS13455 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HEP84_RS13465 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS13470 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HEP84_RS13475 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HEP84_RS13485 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HEP84_RS13490 ENOG4105E5F proteasome HEP84_RS13495 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HEP84_RS13530 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS13540 ENOG4108J59 Extracellular solute-binding protein, family 5 HEP84_RS13545 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HEP84_RS13550 ENOG4105C3R Methionine synthase HEP84_RS13555 ENOG4108K8U Glycerol operon regulatory protein HEP84_RS13560 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP84_RS13565 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP84_RS13575 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HEP84_RS13585 ENOG4105C2J ABC transporter HEP84_RS13595 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HEP84_RS13600 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HEP84_RS13605 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HEP84_RS13610 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HEP84_RS13620 ENOG4108JQ9 ABC transporter HEP84_RS13635 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HEP84_RS13640 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP84_RS13645 ENOG4105JXH GntR family transcriptional regulator HEP84_RS13670 ENOG4105C8N cysteinyl-tRNA synthetase HEP84_RS13690 ENOG4105D7N magnesium and cobalt transport protein CorA HEP84_RS13700 ENOG4105DYW oxidoreductase HEP84_RS13705 ENOG4105CPC Aldo Keto reductase HEP84_RS13710 ENOG4107SID ATP-dependent exodnase (exonuclease v) HEP84_RS13735 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEP84_RS13750 ENOG4105CD8 aminopeptidase N HEP84_RS13755 ENOG4105K5B UPF0225 protein HEP84_RS13760 ENOG4105C6F GntR Family Transcriptional Regulator HEP84_RS13765 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEP84_RS13770 ENOG4105C6Z Gluconate HEP84_RS13775 ENOG4105CHR reductase HEP84_RS13780 ENOG4105CPQ Dehydrogenase HEP84_RS13805 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein HEP84_RS13815 ENOG4105PTV Nudix Hydrolase HEP84_RS13820 ENOG4105VG5 Membrane HEP84_RS13840 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS13845 ENOG4108IG5 Transcriptional regulator HEP84_RS13850 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS13860 ENOG4105EHZ conserved protein UCP016719 HEP84_RS13880 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HEP84_RS13885 ENOG4108Z4X TRANSCRIPTIONal HEP84_RS13905 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS13915 ENOG4108ZHR arsR family transcriptional regulator HEP84_RS13920 ENOG4107Y9U Membrane HEP84_RS13945 ENOG4105D4T Citrate transporter HEP84_RS13950 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP84_RS13955 ENOG4108SGK Tetr family transcriptional regulator HEP84_RS13965 ENOG4105F1J Homogentisate 1,2-dioxygenase HEP84_RS14010 ENOG4105K6V RNA polymerase HEP84_RS14035 ENOG4108TCJ secreted hydrolase HEP84_RS14060 ENOG4107BJW polysaccharide deacetylase HEP84_RS14085 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS14125 ENOG4108Z2K Cupin 2, conserved barrel domain protein HEP84_RS14130 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEP84_RS14135 ENOG4105C0B DNA polymerase III (alpha subunit) HEP84_RS14150 ENOG4106NMR serine protease HEP84_RS14170 ENOG4105CDA abc transporter atp-binding protein HEP84_RS14180 ENOG4108HW4 amino acid AbC transporter HEP84_RS14185 ENOG4105EAB amino acid AbC transporter HEP84_RS14205 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HEP84_RS14210 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS14215 ENOG4105C57 major facilitator superfamily HEP84_RS14225 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP84_RS14235 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP84_RS14270 ENOG4108IV0 ABC, transporter HEP84_RS14295 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HEP84_RS14305 ENOG4105CAT Cytidine monophosphate kinase HEP84_RS14340 ENOG410756H nucleotidyltransferase HEP84_RS14345 ENOG41065RQ ADP-ribosylation crystallin J1 HEP84_RS14355 ENOG4105FE9 pseudouridine synthase HEP84_RS14360 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HEP84_RS14380 ENOG4105DCF alanine dehydrogenase HEP84_RS14390 ENOG4108YZ4 nudix hydrolase HEP84_RS14395 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HEP84_RS14400 ENOG4105BZP glycoside hydrolase 15-related HEP84_RS14420 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HEP84_RS14425 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HEP84_RS14445 ENOG4105E0A ABC, transporter HEP84_RS14450 ENOG4105TVJ transport system, permease HEP84_RS14455 ENOG4105DQ5 transport system permease protein HEP84_RS14460 ENOG4105DSU hydrolase HEP84_RS14490 ENOG4108VX5 3-methyladenine DNA glycosylase HEP84_RS14500 ENOG4108V1U phospholipid-binding protein HEP84_RS14520 ENOG4105DKW ABC transporter HEP84_RS14535 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS14540 ENOG4105ENE Histidine kinase HEP84_RS14545 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HEP84_RS14550 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HEP84_RS14560 ENOG4105IDI abc transporter atp-binding protein HEP84_RS14570 ENOG4105EAC phosphoserine phosphatase HEP84_RS14590 ENOG4107YCY Transcriptional regulator HEP84_RS14600 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HEP84_RS14605 ENOG4105CHR reductase HEP84_RS14620 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HEP84_RS14640 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP84_RS14645 ENOG4107QN1 sodium solute HEP84_RS14665 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F HEP84_RS14715 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP84_RS14730 ENOG4105BZP glycoside hydrolase 15-related HEP84_RS14760 ENOG4105VBF alkaline shock protein HEP84_RS14780 ENOG4105C5H ABC transporter HEP84_RS14810 ENOG4107W7X Aldolase HEP84_RS14830 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HEP84_RS14835 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEP84_RS14840 ENOG4105CTK cobaltochelatase, cobn subunit HEP84_RS14850 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HEP84_RS14855 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEP84_RS14870 ENOG4105CIA precorrin-4 C(11)-methyltransferase HEP84_RS14880 ENOG4105E4R Precorrin-3B C17-methyltransferase HEP84_RS14885 ENOG41081F0 Precorrin-8x methylmutase HEP84_RS14910 ENOG4105CDA abc transporter atp-binding protein HEP84_RS14915 ENOG4105DRP amino acid AbC transporter HEP84_RS14920 ENOG4105CT1 (ABC) transporter HEP84_RS14925 ENOG4105C5R Aminotransferase HEP84_RS14930 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HEP84_RS14935 ENOG4108JPW Aminotransferase HEP84_RS14940 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HEP84_RS14945 ENOG4105EV8 ectoine hydroxylase HEP84_RS14975 ENOG4107HP6 Transcriptional regulator HEP84_RS14985 ENOG4105CJN penicillin-binding protein HEP84_RS14990 ENOG4105C7N Xanthine uracil vitamin C permease HEP84_RS14995 ENOG4105NAF rna polymerase sigma factor HEP84_RS15010 ENOG4108J21 pectate lyase HEP84_RS15060 ENOG4108J20 pectate lyase HEP84_RS15065 ENOG4107TDE lipolytic protein G-D-S-L family HEP84_RS15070 ENOG4107T3P ABC, transporter HEP84_RS15075 ENOG4105E4I Glycoside hydrolase family 28 HEP84_RS15105 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP84_RS15110 ENOG4105DRR Transcriptional regulator, GntR family HEP84_RS15135 ENOG4105E9Z Nad-dependent epimerase dehydratase HEP84_RS15140 ENOG4105E98 transcriptional regulator DeoR family HEP84_RS15160 ENOG4105CPQ Dehydrogenase HEP84_RS15170 ENOG4105XEA Tetr family transcriptional regulator HEP84_RS15185 ENOG4107XBN GntR Family Transcriptional Regulator HEP84_RS15225 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP84_RS15245 ENOG4105EEM helicase HEP84_RS15250 ENOG4105E2A Dehydrogenase HEP84_RS15255 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HEP84_RS15260 ENOG4108RFG Tetr family transcriptional regulator HEP84_RS15265 ENOG410814C multidrug resistance protein HEP84_RS15285 ENOG4108UNV SUF system FeS assembly protein, NifU family HEP84_RS15290 ENOG4105C9B Cysteine desulfurase HEP84_RS15295 ENOG4105C3K feS assembly ATPase SufC HEP84_RS15305 ENOG4105JRK feS assembly protein SufD HEP84_RS15320 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HEP84_RS15325 ENOG4105CJ1 ABC, transporter HEP84_RS15350 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HEP84_RS15360 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEP84_RS15375 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HEP84_RS15380 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HEP84_RS15385 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HEP84_RS15395 ENOG4105CG3 alpha amylase, catalytic region HEP84_RS15400 ENOG4107T3P ABC, transporter HEP84_RS15405 ENOG4105U3E Transcriptional regulator HEP84_RS15410 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS15425 ENOG4107QP8 phosphohexose isomerase HEP84_RS15445 ENOG4105CP7 Triose-phosphate isomerase HEP84_RS15450 ENOG4105BZA Phosphoglycerate kinase HEP84_RS15455 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEP84_RS15465 ENOG4105CIE May be required for sporulation (By similarity) HEP84_RS15470 ENOG4105CHW UPF0052 protein HEP84_RS15475 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HEP84_RS15480 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HEP84_RS15495 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS15505 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEP84_RS15520 ENOG4107R0W ABC transporter HEP84_RS15525 ENOG4105E5Q amino acid AbC transporter HEP84_RS15535 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HEP84_RS15540 ENOG4105CSH Transporter HEP84_RS15565 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HEP84_RS15570 ENOG4105BZU Histidine kinase HEP84_RS15575 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEP84_RS15580 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEP84_RS15600 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HEP84_RS15610 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS15615 ENOG4105D7N magnesium and cobalt transport protein CorA HEP84_RS15645 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS15650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS15690 ENOG4106A3M Cytochrome p-450 HEP84_RS15695 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP84_RS15730 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HEP84_RS15740 ENOG4105DRR Transcriptional regulator, GntR family HEP84_RS15785 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HEP84_RS15805 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS15850 ENOG4105KA0 thioesterase Superfamily protein HEP84_RS15860 ENOG4105C32 Amino acid ABC transporter (Permease) HEP84_RS15865 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HEP84_RS15870 ENOG4105C0Z ABC transporter HEP84_RS15875 ENOG4108IV0 ABC, transporter HEP84_RS15910 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HEP84_RS15930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS15935 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HEP84_RS15940 ENOG41063TF transcriptional regulator (AraC HEP84_RS15965 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HEP84_RS15975 ENOG41060WC Enoyl-CoA hydratase HEP84_RS15990 ENOG4105EA8 2-Nitropropane dioxygenase HEP84_RS15995 ENOG4105F2C Acetyl-CoA acetyltransferase HEP84_RS16000 ENOG4108RZE Tetr family transcriptional regulator HEP84_RS16010 ENOG4105D2B acyl-CoA dehydrogenase HEP84_RS16015 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS16020 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP84_RS16025 ENOG41090B9 response to stress HEP84_RS16030 ENOG4105MUA Resistance protein HEP84_RS16045 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS16060 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS16070 ENOG4105CBC glutamate synthase HEP84_RS16080 ENOG41065RQ ADP-ribosylation crystallin J1 HEP84_RS16100 ENOG4108RVA ribokinase HEP84_RS16105 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP84_RS16110 ENOG4105CI0 Citrate lyase HEP84_RS16125 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HEP84_RS16130 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HEP84_RS16140 ENOG4105DK0 Indole-3-glycerol phosphate synthase HEP84_RS16165 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HEP84_RS16185 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HEP84_RS16190 ENOG4108176 endoribonuclease L-psp HEP84_RS16195 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HEP84_RS16200 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HEP84_RS16210 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HEP84_RS16215 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP84_RS16220 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HEP84_RS16240 ENOG4108Z66 YbaK ebsC protein HEP84_RS16270 ENOG4105C0B DNA polymerase III (alpha subunit) HEP84_RS16315 ENOG41082BV acetyltransferase HEP84_RS16325 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HEP84_RS16340 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HEP84_RS16345 ENOG4107VQS DivIVA family HEP84_RS16355 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HEP84_RS16360 ENOG4105DFA alanine racemase domain protein HEP84_RS16370 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HEP84_RS16380 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HEP84_RS16390 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HEP84_RS16395 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HEP84_RS16405 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HEP84_RS16420 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HEP84_RS16430 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HEP84_RS16450 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEP84_RS16460 ENOG4105CDA abc transporter atp-binding protein HEP84_RS16470 ENOG4107Z3H Transcriptional regulator, TetR family HEP84_RS16480 ENOG4105EWK phytoene HEP84_RS16520 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HEP84_RS16530 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HEP84_RS16540 ENOG4108UQY Iron-storage protein HEP84_RS16550 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HEP84_RS16570 ENOG4105CTQ phosphohexokinase HEP84_RS16580 ENOG4105ENE Histidine kinase HEP84_RS16605 ENOG4105DKQ ROK family HEP84_RS16650 ENOG4105UQX Mate efflux family protein HEP84_RS16695 ENOG4105C9B Cysteine desulfurase HEP84_RS16700 ENOG4108I0Q anthranilate phosphoribosyltransferase HEP84_RS16705 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP84_RS16710 ENOG4107EUI c reductase, iron-sulfur HEP84_RS16715 ENOG4107UDY cytochrome C HEP84_RS16720 ENOG4105CCU oxidase (Subunit III) HEP84_RS16730 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HEP84_RS16735 ENOG4105MCD Part of cytochrome c oxidase, its function is HEP84_RS16740 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP84_RS16745 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HEP84_RS16755 ENOG4107T4Z adenosine kinase HEP84_RS16775 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HEP84_RS16780 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS16810 ENOG4105C0H protease HEP84_RS16830 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HEP84_RS16835 ENOG4105CRK lysyL-tRNA synthetase HEP84_RS16850 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HEP84_RS16855 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HEP84_RS16880 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEP84_RS16910 ENOG4105ECP epimerase HEP84_RS16925 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEP84_RS16930 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HEP84_RS16950 ENOG4105C5F glutamine synthetase HEP84_RS16960 ENOG4105D0M Protease HtpX homolog HEP84_RS17000 ENOG4108222 arsenate reductase HEP84_RS17005 ENOG4106SPC secreted protein HEP84_RS17010 ENOG4107R5B glutamine synthetase HEP84_RS17015 ENOG4107NHD transcriptional regulator HEP84_RS17030 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS17065 ENOG41060BG Tetr family transcriptional regulator HEP84_RS17105 ENOG4105EG2 ABC transporter, permease HEP84_RS17110 ENOG4105CG3 alpha amylase, catalytic region HEP84_RS17115 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS17130 ENOG4107RSM transcriptional regulator HEP84_RS17135 ENOG4105FDR Membrane HEP84_RS17140 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HEP84_RS17145 ENOG4105FBN Acid phosphatase HEP84_RS17200 ENOG4105C5F glutamine synthetase HEP84_RS17205 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP84_RS17210 ENOG41081JD Transcriptional regulator HEP84_RS17230 ENOG4105C4K Nad synthetase HEP84_RS17235 ENOG4105F27 Major Facilitator HEP84_RS17250 ENOG4105C57 major facilitator superfamily HEP84_RS17255 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HEP84_RS17275 ENOG4107XZ0 Peptidase M50 HEP84_RS17325 ENOG410650H (LipO)protein HEP84_RS17330 ENOG4105DBE peroxidase HEP84_RS17340 ENOG4106A0S HEP84_RS17345 ENOG4105C8T Leucyl-tRNA synthetase HEP84_RS17355 ENOG4105CIK Amidinotransferase HEP84_RS17365 ENOG4107S1E Beta-lactamase HEP84_RS17370 ENOG4105C2C drug resistance transporter, Bcr CflA HEP84_RS17380 ENOG4105CHR reductase HEP84_RS17395 ENOG4105C19 ABC transporter HEP84_RS17405 ENOG4108VGI doxx family HEP84_RS17420 ENOG4105GCF PGAM HEP84_RS17425 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS17430 ENOG4105CHR reductase HEP84_RS17470 ENOG4105CY3 ABC transporter, permease HEP84_RS17535 ENOG4105E7U AraC family transcriptional regulator HEP84_RS17555 ENOG4107XFJ UPF0246 protein HEP84_RS17560 ENOG4108UHU Aldolase HEP84_RS17565 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP84_RS17585 ENOG4105EGD dinuclear metal center protein, YbgI family HEP84_RS17600 ENOG4105CHR reductase HEP84_RS17615 ENOG4108M15 ABC transporter HEP84_RS17655 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS17680 ENOG4105DYW oxidoreductase HEP84_RS17700 ENOG4107QVI Methyltransferase, type 11 HEP84_RS17710 ENOG4108SGK Tetr family transcriptional regulator HEP84_RS17750 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HEP84_RS17790 ENOG4105XPP Protein of unknown function (DUF1275) HEP84_RS17815 ENOG4105F2C Acetyl-CoA acetyltransferase HEP84_RS17820 ENOG4106A3M Cytochrome p-450 HEP84_RS17835 ENOG4105CSH Transporter HEP84_RS17930 ENOG4105D3W isochorismatase HEP84_RS17935 ENOG41080V3 Major Facilitator superfamily HEP84_RS17985 ENOG4105S7M extracellular small neutral protease HEP84_RS18030 ENOG4105BZ4 penicillin-binding protein HEP84_RS18045 ENOG4105DAX Pfam:DUF2983 HEP84_RS18090 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEP84_RS18095 ENOG4105EYW Ion transport protein HEP84_RS18120 ENOG4105CPC Aldo Keto reductase HEP84_RS18125 ENOG4105VUF Transcriptional regulator HEP84_RS18155 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP84_RS18160 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP84_RS18180 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEP84_RS18190 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP84_RS18195 ENOG4108R86 Transcriptional regulator HEP84_RS18210 ENOG4106KE4 Dehydrogenase HEP84_RS18215 ENOG4105DUM transcriptional regulator, lysR family HEP84_RS18220 ENOG4105NGS secreted protein HEP84_RS18225 ENOG4105EXN Sulfate transport protein CysZ HEP84_RS18240 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP84_RS18245 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP84_RS18275 ENOG4105DFW ABC transporter HEP84_RS18285 ENOG4108HWW ABC transporter HEP84_RS18290 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEP84_RS18295 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP84_RS18330 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP84_RS18360 ENOG4108YIQ Alpha beta hydrolase HEP84_RS18410 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HEP84_RS18420 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP84_RS18430 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HEP84_RS18435 ENOG41069M3 Transcriptional regulator HEP84_RS18465 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HEP84_RS18535 ENOG4105D8K carboxyl transferase HEP84_RS18545 ENOG4105DFF Rod shape-determining protein mreb HEP84_RS18590 ENOG4105C32 Amino acid ABC transporter (Permease) HEP84_RS18600 ENOG4108IV0 ABC, transporter HEP84_RS18605 ENOG4105C0Z ABC transporter HEP84_RS18610 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS18660 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS18665 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HEP84_RS18675 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HEP84_RS18685 ENOG410836F Transposase HEP84_RS18690 ENOG4107GZ4 SanA protein HEP84_RS18740 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS18755 ENOG4107QZF nitrite reductase NADPH large subunit HEP84_RS18765 ENOG4108XFH Transcriptional regulator HEP84_RS18770 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP84_RS18775 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP84_RS18795 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEP84_RS18800 ENOG4105E2R ROK family HEP84_RS18835 ENOG4105NAF rna polymerase sigma factor HEP84_RS18870 ENOG4105CPC Aldo Keto reductase HEP84_RS18880 ENOG4108SGK Tetr family transcriptional regulator HEP84_RS18885 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS18890 ENOG4108KPJ rna polymerase sigma factor HEP84_RS18920 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HEP84_RS18925 ENOG4105DSE periplasmic solute binding protein HEP84_RS18930 ENOG4105FDK ABC transporter HEP84_RS18945 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HEP84_RS18950 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HEP84_RS18980 ENOG4108762 serine threonine protein kinase HEP84_RS18985 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS18990 ENOG4105BZU Histidine kinase HEP84_RS18995 ENOG4105CJ1 ABC, transporter HEP84_RS19010 ENOG4105JXH GntR family transcriptional regulator HEP84_RS19015 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP84_RS19025 ENOG4105C3U ABC transporter HEP84_RS19030 ENOG4108JQ7 (ABC) transporter HEP84_RS19035 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP84_RS19050 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP84_RS19060 ENOG4105D4Y metalloprotease HEP84_RS19115 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HEP84_RS19135 ENOG4105MSB protein, conserved in bacteria HEP84_RS19145 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HEP84_RS19170 ENOG4105ESP cell wall surface anchor family protein HEP84_RS19200 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HEP84_RS19205 ENOG4107YU2 histidine triad (hIT) protein HEP84_RS19210 ENOG4107RE3 peptidase, S41 HEP84_RS19230 ENOG4107QWG 2-Nitropropane dioxygenase HEP84_RS19235 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HEP84_RS19240 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HEP84_RS19265 ENOG4105BZU Histidine kinase HEP84_RS19270 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HEP84_RS19280 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HEP84_RS19290 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HEP84_RS19315 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HEP84_RS19320 ENOG4105EPR degv family HEP84_RS19330 ENOG4105C8T Leucyl-tRNA synthetase HEP84_RS19340 ENOG4107QIZ NADH dehydrogenase HEP84_RS19380 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP84_RS19395 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HEP84_RS19410 ENOG4105D0M Protease HtpX homolog HEP84_RS19425 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HEP84_RS19435 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HEP84_RS19465 ENOG4105DGI Alkaline phosphatase HEP84_RS19470 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HEP84_RS19475 ENOG4105K46 50S ribosomal protein l27 HEP84_RS19480 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HEP84_RS19515 ENOG4105CVK Glutamate decarboxylase HEP84_RS19530 ENOG4107GJV short-chain dehydrogenase reductase HEP84_RS19555 ENOG4105CNI cell division protein FtsW HEP84_RS19575 ENOG4105DFF Rod shape-determining protein mreb HEP84_RS19580 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HEP84_RS19590 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HEP84_RS19595 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HEP84_RS19620 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HEP84_RS19625 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP84_RS19630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP84_RS19635 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HEP84_RS19655 ENOG4108TGC Acyltransferase HEP84_RS19685 ENOG4105C85 amino acid HEP84_RS19705 ENOG4105E2R ROK family HEP84_RS19715 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP84_RS19720 ENOG4105E2Y ABC, transporter HEP84_RS19730 ENOG4107SVN transposase HEP84_RS19740 ENOG4105C85 amino acid HEP84_RS19750 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP84_RS19760 ENOG4105MC2 DSBA oxidoreductase HEP84_RS19775 ENOG4105BZU Histidine kinase HEP84_RS19800 ENOG4108UYE Lactoylglutathione lyase HEP84_RS19875 ENOG4108KTG Membrane protein, drug metabolite transporter HEP84_RS19890 ENOG4107SCK Monooxygenase HEP84_RS19925 ENOG4105CJ1 ABC, transporter HEP84_RS19945 ENOG4105D8X mechanosensitive ion channel HEP84_RS19965 ENOG4105MWK D-amino acid dehydrogenase, small subunit HEP84_RS19970 ENOG4105CDA abc transporter atp-binding protein HEP84_RS19975 ENOG4105EAD ABC transporter HEP84_RS19980 ENOG4105EAB amino acid AbC transporter HEP84_RS20000 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HEP84_RS20005 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HEP84_RS20010 ENOG4105F8D glycoside hydrolase family 4 HEP84_RS20025 ENOG4105CT1 (ABC) transporter HEP84_RS20055 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HEP84_RS20060 ENOG4108Z18 K06886 hemoglobin HEP84_RS20110 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS20155 ENOG4105VHU single-stranded DNA-binding protein HEP84_RS20220 ENOG4105S2J secreted protein HEP84_RS20260 ENOG4105C26 Dehydrogenase HEP84_RS20265 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP84_RS20270 ENOG4105DH8 myo-inositol catabolism HEP84_RS20280 ENOG4105EDK PfkB domain protein HEP84_RS20285 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HEP84_RS20305 ENOG4107R13 MMPL domain protein HEP84_RS20335 ENOG4105C7H Helicase, RecD TraA family HEP84_RS20350 ENOG4105C2J ABC transporter HEP84_RS20355 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP84_RS20360 ENOG4108RVA ribokinase HEP84_RS20365 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HEP84_RS20390 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS20395 ENOG4105HSS phospholipase C HEP84_RS20400 ENOG410645S MarR family Transcriptional regulator HEP84_RS20420 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HEP84_RS20425 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HEP84_RS20430 ENOG4105D17 glycoside hydrolase, family 3 domain protein HEP84_RS20500 ENOG4108K8S endonuclease I HEP84_RS20505 ENOG4105C7K acetolactate synthase HEP84_RS20515 ENOG4105CK7 Sodium proline symporter HEP84_RS20525 ENOG4108XFF HEP84_RS20535 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS20550 ENOG4105C29 acyl-CoA thioesterase HEP84_RS20570 ENOG4107QX3 carboxylase HEP84_RS20580 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HEP84_RS20585 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS20615 ENOG4105DY8 decarboxylase HEP84_RS20620 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HEP84_RS20630 ENOG4105DUU IucA IucC family protein HEP84_RS20635 ENOG4105E2D ec 3.2.1.52 HEP84_RS20655 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP84_RS20675 ENOG4105ECQ AraC Family Transcriptional Regulator HEP84_RS20680 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HEP84_RS20700 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS20715 ENOG4105DRS transport system, permease HEP84_RS20730 ENOG4108NNZ chitinase HEP84_RS20735 ENOG410804D Sensor Signal Transduction Histidine Kinase HEP84_RS20765 ENOG4105CVJ phosphoglycerate mutase HEP84_RS20810 ENOG4105BZU Histidine kinase HEP84_RS20815 ENOG4105DEN Luciferase family HEP84_RS20830 ENOG4105C5I Dehydrogenase HEP84_RS20835 ENOG4105DV0 amidase (EC 3.5.1.4 HEP84_RS20875 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS20890 ENOG4105DFM M18 family aminopeptidase HEP84_RS20910 ENOG4105J5T Amp-dependent synthetase and ligase HEP84_RS20920 ENOG4108M1A Chitin-binding protein HEP84_RS20960 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HEP84_RS20970 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HEP84_RS20995 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HEP84_RS21000 ENOG4108MP3 ABC transporter, permease HEP84_RS21005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS21015 ENOG4105MWK D-amino acid dehydrogenase, small subunit HEP84_RS21020 ENOG41080U6 GntR family transcriptional regulator HEP84_RS21035 ENOG4105D9R oxidoreductase HEP84_RS21040 ENOG41090KN UPF0303 protein HEP84_RS21050 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HEP84_RS21070 ENOG4108U4N (sortase) family HEP84_RS21080 ENOG4105CVA phosphate HEP84_RS21140 ENOG41067TZ transcriptional regulator, MarR family HEP84_RS21165 ENOG4107QNK )-transporter HEP84_RS21170 ENOG4106BRA Membrane HEP84_RS21185 ENOG4105CJ1 ABC, transporter HEP84_RS21200 ENOG4105BZ4 penicillin-binding protein HEP84_RS21240 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HEP84_RS21250 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HEP84_RS21295 ENOG4105C85 amino acid HEP84_RS21310 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HEP84_RS21320 ENOG4108RWI nicotinamidase HEP84_RS21350 ENOG4105KF0 sporulation and cell division protein, SsgA HEP84_RS21355 ENOG4105CQB FAD linked oxidase domain protein HEP84_RS21365 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HEP84_RS21385 ENOG41063PX domain protein HEP84_RS21390 ENOG4105DTQ mandelate racemase muconate lactonizing HEP84_RS21410 ENOG4105CUB amino acid HEP84_RS21425 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP84_RS21460 ENOG4105E2D ec 3.2.1.52 HEP84_RS21475 ENOG4107T3P ABC, transporter HEP84_RS21485 ENOG4108UJU UPF0301 protein HEP84_RS21490 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HEP84_RS21495 ENOG4108426 dNA-binding protein HEP84_RS21505 ENOG4105EEM helicase HEP84_RS21535 ENOG4105DQQ Major facilitator superfamily MFS_1 HEP84_RS21555 ENOG4105EMY transcriptional regulator HEP84_RS21580 ENOG4105CJQ hydrolase, family 31 HEP84_RS21615 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HEP84_RS21620 ENOG4105CN1 protease HEP84_RS21630 ENOG4105CAK Cell division ATP-binding protein ftsE HEP84_RS21645 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HEP84_RS21650 ENOG4108QVN serine threonine protein kinase HEP84_RS21655 ENOG4108UGD Serine Threonine protein kinase HEP84_RS21685 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HEP84_RS21690 ENOG4107SJB teichoic acid biosynthesis HEP84_RS21695 ENOG4107SJB teichoic acid biosynthesis HEP84_RS21700 ENOG4105K64 Glycosyl transferase, family 2 HEP84_RS21715 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP84_RS21720 ENOG4105K56 Transcriptional regulator HEP84_RS21760 ENOG4108S01 response regulator HEP84_RS21780 ENOG4105EY8 ABC transporter HEP84_RS21785 ENOG4105CG5 Glycosyl transferase (Group 1 HEP84_RS21790 ENOG4107SJB teichoic acid biosynthesis HEP84_RS21800 ENOG4105C7I Dehydrogenase HEP84_RS21825 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP84_RS21835 ENOG4105T0Z Conserved Protein HEP84_RS21840 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS21845 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HEP84_RS21855 ENOG4105G3P Lipoprotein lpqB HEP84_RS21860 ENOG4105BZU Histidine kinase HEP84_RS21865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS21870 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HEP84_RS21885 ENOG4108WQ6 secreted protein HEP84_RS21890 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HEP84_RS21930 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HEP84_RS21940 ENOG4105EIP mannose-6-phosphate isomerase HEP84_RS21950 ENOG4105W49 UPF0434 protein HEP84_RS21955 ENOG4107QKV phosphomannomutase HEP84_RS21960 ENOG4105DAA L-lactate HEP84_RS21980 ENOG4107RGC Glycosyl transferase, family 2 HEP84_RS21985 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP84_RS22000 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HEP84_RS22010 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HEP84_RS22030 ENOG4108KGH TRANSCRIPTIONal HEP84_RS22045 ENOG4108KGH TRANSCRIPTIONal HEP84_RS22050 ENOG4108KGH TRANSCRIPTIONal HEP84_RS22060 ENOG4105PAD Hydrolase HEP84_RS22070 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP84_RS22090 ENOG4108Z4X TRANSCRIPTIONal HEP84_RS22095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP84_RS22120 ENOG41065SU Two-component system sensor kinase HEP84_RS22125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS22130 ENOG4105DUX Transporter HEP84_RS22170 ENOG41082AN stage II sporulation protein HEP84_RS22175 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS22185 ENOG4105CI2 imidazolone-5-propionate hydrolase HEP84_RS22200 ENOG4105CGP Urocanate hydratase HEP84_RS22245 ENOG4105C84 Histidine ammonia-lyase HEP84_RS22250 ENOG4108IJ8 ABC transporter HEP84_RS22255 ENOG4105E90 ABC transporter HEP84_RS22260 ENOG4105E90 ABC transporter HEP84_RS22270 ENOG41060NJ transcriptional regulator HEP84_RS22305 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS22340 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS22345 ENOG4107RBB ABC transporter, permease HEP84_RS22350 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEP84_RS22355 ENOG4105CEP NADH dehydrogenase HEP84_RS22375 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HEP84_RS22390 ENOG4106A3M Cytochrome p-450 HEP84_RS22455 ENOG4105XYF acetyltransferase HEP84_RS22495 ENOG4105EJ2 Transcriptional regulator HEP84_RS22510 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS22515 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS22530 ENOG4107QN1 sodium solute HEP84_RS22560 ENOG4108ZGX Histidine kinase HEP84_RS22575 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HEP84_RS22580 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEP84_RS22585 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HEP84_RS22590 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HEP84_RS22600 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HEP84_RS22610 ENOG41067SE Tetr family transcriptional regulator HEP84_RS22620 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HEP84_RS22625 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEP84_RS22630 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS22640 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HEP84_RS22670 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEP84_RS22690 ENOG4105C5H ABC transporter HEP84_RS22700 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HEP84_RS22705 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HEP84_RS22715 ENOG4105F8V Hydrolase, tatD family HEP84_RS22755 ENOG4105CJN penicillin-binding protein HEP84_RS22765 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HEP84_RS22795 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEP84_RS22805 ENOG4108JJB ABC transporter HEP84_RS22810 ENOG4105K56 Transcriptional regulator HEP84_RS22815 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP84_RS22830 ENOG4105EYF MMPL domain protein HEP84_RS22850 ENOG4108R85 Short chain dehydrogenase HEP84_RS22855 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP84_RS22860 ENOG4105F95 Monooxygenase HEP84_RS22870 ENOG4105CGK Exodeoxyribonuclease III HEP84_RS22890 ENOG4108Z9I -acetyltransferase HEP84_RS22895 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP84_RS22900 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP84_RS22910 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEP84_RS22915 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HEP84_RS22925 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HEP84_RS22940 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HEP84_RS22950 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HEP84_RS22970 ENOG4105FF0 ErfK YbiS YcfS YnhG HEP84_RS22985 ENOG4105DM4 PTS System HEP84_RS22995 ENOG4105E98 transcriptional regulator DeoR family HEP84_RS23050 ENOG4108Z7F N-acetyltransferase HEP84_RS23055 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HEP84_RS23080 ENOG4107HP6 Transcriptional regulator HEP84_RS23085 ENOG4105C57 major facilitator superfamily HEP84_RS23145 ENOG4105C85 amino acid HEP84_RS23230 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator HEP84_RS23235 ENOG4105CNN ABC, transporter HEP84_RS23240 ENOG4105C2J ABC transporter HEP84_RS23245 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS23290 ENOG4108ZJ4 polysaccharide deacetylase HEP84_RS23310 ENOG4105CZV ABC transporter HEP84_RS23315 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS23355 ENOG4105DNP FAD linked oxidase domain protein HEP84_RS23405 ENOG4108V06 Glutathione peroxidase HEP84_RS23420 ENOG4105DZ1 carboxypeptidase HEP84_RS23475 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP84_RS23490 ENOG4105EMU Dehydrogenase HEP84_RS23495 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP84_RS23500 ENOG41088PD hydrolase HEP84_RS23545 ENOG4105F0K SARP family transcriptional regulator HEP84_RS23565 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS23585 ENOG4108762 serine threonine protein kinase HEP84_RS23595 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HEP84_RS23605 ENOG4105D2B acyl-CoA dehydrogenase HEP84_RS23640 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEP84_RS23645 ENOG4107RSM transcriptional regulator HEP84_RS23695 ENOG4105CGU Enoyl-CoA hydratase HEP84_RS23700 ENOG4105MXW flavin reductase domain protein, FMN-binding HEP84_RS23705 ENOG4105D2S major facilitator superfamily HEP84_RS23725 ENOG4105CC9 acyl-Coa dehydrogenase HEP84_RS23745 ENOG4105D2B acyl-CoA dehydrogenase HEP84_RS23750 ENOG4105CC9 acyl-Coa dehydrogenase HEP84_RS23760 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS23765 ENOG4107EG8 signal transduction protein with EFhand domain HEP84_RS23770 ENOG41082AN stage II sporulation protein HEP84_RS23775 ENOG4105K6V RNA polymerase HEP84_RS23825 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP84_RS23835 ENOG4108SU4 UPF0309 protein HEP84_RS23855 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEP84_RS23865 ENOG4105CGU Enoyl-CoA hydratase HEP84_RS23870 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS23885 ENOG4107QX3 carboxylase HEP84_RS23915 ENOG4105BZ1 (ABC) transporter HEP84_RS23920 ENOG4105CQB FAD linked oxidase domain protein HEP84_RS23945 ENOG4106A3M Cytochrome p-450 HEP84_RS23955 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HEP84_RS23960 ENOG4106R7G Glycoside hydrolase family 5 HEP84_RS23985 ENOG4105CPC Aldo Keto reductase HEP84_RS24000 ENOG4105XMC MarR family Transcriptional regulator HEP84_RS24010 ENOG4105C7N Xanthine uracil vitamin C permease HEP84_RS24020 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEP84_RS24035 ENOG410836F Transposase HEP84_RS24060 ENOG4108N0W Major Facilitator superfamily HEP84_RS24070 ENOG4108UIH futalosine nucleosidase HEP84_RS24075 ENOG4105E63 Pfam:DUF178 HEP84_RS24080 ENOG4105VEQ Cold shock protein HEP84_RS24105 ENOG4105CFI type iii restriction protein res subunit HEP84_RS24120 ENOG4105EEM helicase HEP84_RS24125 ENOG4106N3A copper homeostasis protein cutc HEP84_RS24140 ENOG4105KNA -acetyltransferase HEP84_RS24155 ENOG4105QEK Transcriptional regulator HEP84_RS24160 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HEP84_RS24165 ENOG4105C5Y PTS System HEP84_RS24215 ENOG4105EBR Carboxylesterase HEP84_RS24225 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HEP84_RS24245 ENOG4105C3Q Glycosyl transferase, family 2 HEP84_RS24270 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HEP84_RS24275 ENOG4105CE4 GlcNAc 6-P deacetylase HEP84_RS24335 ENOG4105CD8 aminopeptidase N HEP84_RS24360 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP84_RS24445 ENOG4105C2N RNA methyltransferase TrmH family group 3 HEP84_RS24450 ENOG4105C8N cysteinyl-tRNA synthetase HEP84_RS24455 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HEP84_RS24460 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HEP84_RS24465 ENOG4108VJ1 Transcriptional regulator (CarD family HEP84_RS24485 ENOG4105BZU Histidine kinase HEP84_RS24555 ENOG4105DNP FAD linked oxidase domain protein HEP84_RS24570 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP84_RS24595 ENOG4105QNJ serralysin (EC 3.4.24.40) HEP84_RS24605 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP84_RS24640 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP84_RS24675 ENOG4105CPQ Dehydrogenase HEP84_RS24725 ENOG4105HHS UPF0256 protein HEP84_RS24740 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HEP84_RS24745 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HEP84_RS24750 ENOG41090R7 Ferric uptake HEP84_RS24755 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HEP84_RS24785 ENOG4105PKJ carbohydrate binding HEP84_RS24790 ENOG4105KHC sulfurtransferase HEP84_RS24815 ENOG4107NHD transcriptional regulator HEP84_RS24820 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS24825 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP84_RS24830 ENOG4105C0H protease HEP84_RS24855 ENOG4105ETX regulatoR HEP84_RS24860 ENOG4105BZ1 (ABC) transporter HEP84_RS24875 ENOG4105CGH 5'-nucleotidase HEP84_RS24880 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP84_RS24895 ENOG4105CJ1 ABC, transporter HEP84_RS24910 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS24915 ENOG4105CZV ABC transporter HEP84_RS24930 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HEP84_RS24960 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS24965 ENOG4105CJ3 phosphate transporter HEP84_RS24975 ENOG4105VPX protein, conserved in bacteria HEP84_RS24995 ENOG4105DNP FAD linked oxidase domain protein HEP84_RS25000 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP84_RS25005 ENOG4105E4C Lytic transglycosylase catalytic HEP84_RS25120 ENOG4105ESP cell wall surface anchor family protein HEP84_RS25140 ENOG4105D5U fad dependent oxidoreductase HEP84_RS25145 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HEP84_RS25155 ENOG4105CPC Aldo Keto reductase HEP84_RS25190 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HEP84_RS25210 ENOG4105C1J atp-dependent rna helicase HEP84_RS25250 ENOG4105CQ7 ATP-dependent helicase HEP84_RS25270 ENOG4108TAC HEP84_RS25285 ENOG4105CXB phosphoribosylaminoimidazole synthetase HEP84_RS25310 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HEP84_RS25315 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HEP84_RS25320 ENOG410839H phosphoribosylformylglycinamidine synthase HEP84_RS25365 ENOG4105C8V SAICAR synthetase HEP84_RS25380 ENOG4105C12 Phosphoribosylglycinamide synthetase HEP84_RS25415 ENOG4105I6B RNA polymerase HEP84_RS25465 ENOG4105D7A ATP-binding protein HEP84_RS25480 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HEP84_RS25495 ENOG4108Z6B deaminase HEP84_RS25510 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HEP84_RS25515 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS25520 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS25535 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEP84_RS25540 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP84_RS25550 ENOG410905P Pyridoxamine 5-phosphate HEP84_RS25560 ENOG4105C57 major facilitator superfamily HEP84_RS25565 ENOG4105EDW glycosyl transferase, family 39 HEP84_RS25575 ENOG4105BZU Histidine kinase HEP84_RS25580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS25590 ENOG4105KAC Antibiotic biosynthesis monooxygenase HEP84_RS25890 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS25895 ENOG4105NAF rna polymerase sigma factor HEP84_RS25910 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS25920 ENOG4105X7H acyl-CoA dehydrogenase HEP84_RS26055 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP84_RS26075 ENOG4107T6F Xaa-Pro aminopeptidase HEP84_RS26115 ENOG4105BZU Histidine kinase HEP84_RS26150 ENOG4105DBE peroxidase HEP84_RS26155 ENOG4105CQC Prephenate dehydratase HEP84_RS26160 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HEP84_RS26165 ENOG410667J hydrolase HEP84_RS26195 ENOG4105DA5 (ABC) transporter HEP84_RS26210 ENOG4107SWG transcriptional regulator MERR family HEP84_RS26215 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HEP84_RS26225 ENOG410667J hydrolase HEP84_RS26240 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEP84_RS26245 ENOG4105C4M (Ubiquinol oxidase) subunit I HEP84_RS26250 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP84_RS26255 ENOG4107P2S Transcriptional regulator HEP84_RS26260 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HEP84_RS26275 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HEP84_RS26300 ENOG4106048 Cupin 2, conserved barrel domain protein HEP84_RS26305 ENOG41082T9 Membrane HEP84_RS26310 ENOG4105KJF protein tyrosine phosphatase HEP84_RS26315 ENOG4105C28 cystathionine HEP84_RS26350 ENOG4105F27 Major Facilitator HEP84_RS26370 ENOG4105CDU Replicative dna helicase HEP84_RS26380 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HEP84_RS26385 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEP84_RS26390 ENOG4107YH6 single-stranded DNA-binding protein HEP84_RS26395 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HEP84_RS26430 ENOG4105CZA synthase HEP84_RS26445 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HEP84_RS26475 ENOG4105C3M thioredoxin reductase HEP84_RS26480 ENOG4105K63 Thioredoxin HEP84_RS26495 ENOG4107QJE Chromosome Partitioning Protein HEP84_RS26500 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HEP84_RS26510 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HEP84_RS26515 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HEP84_RS26520 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HEP84_RS26535 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEP84_RS26540 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP84_RS26545 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HEP84_RS26550 ENOG4105K7N UPF0232 protein HEP84_RS26555 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP84_RS26560 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP84_RS26590 ENOG4108UGD Serine Threonine protein kinase HEP84_RS26620 ENOG4105ZJT Cell division protein CrgA HEP84_RS26630 ENOG4108U4N (sortase) family HEP84_RS26650 ENOG4108RN7 integral membrane protein HEP84_RS26665 ENOG4105CJN penicillin-binding protein HEP84_RS26680 ENOG4105HZM Fha domain containing protein HEP84_RS26710 ENOG41064MX Tetr family transcriptional regulator HEP84_RS26715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS26730 ENOG4108JIK carboxylase HEP84_RS26745 ENOG4105CZS beta-ketoacyl synthase HEP84_RS26765 ENOG4107SCK Monooxygenase HEP84_RS26790 ENOG4105D8K carboxyl transferase HEP84_RS26830 ENOG4105KVH Transcriptional regulator HEP84_RS26835 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP84_RS26855 ENOG4105DNP FAD linked oxidase domain protein HEP84_RS26875 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HEP84_RS26915 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HEP84_RS26925 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP84_RS26930 ENOG4108IG5 Transcriptional regulator HEP84_RS26950 ENOG4107QSN dihydrolipoamide acetyltransferase HEP84_RS26955 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HEP84_RS26995 ENOG4107QPV Serine Threonine protein kinase HEP84_RS27025 ENOG4105CPP Dehydrogenase, E1 component HEP84_RS27030 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HEP84_RS27040 ENOG4108WYP Transcriptional regulator HEP84_RS27070 ENOG4105ECQ AraC Family Transcriptional Regulator HEP84_RS27090 ENOG4105DFM M18 family aminopeptidase HEP84_RS27095 ENOG4105CSU acyl-Coa dehydrogenase HEP84_RS27105 ENOG4105EUB pirin domain protein HEP84_RS27120 ENOG4105C9M aspartyl-trna synthetase HEP84_RS27150 ENOG4108J20 pectate lyase HEP84_RS27160 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HEP84_RS27175 ENOG4108KXM LysR family Transcriptional regulator HEP84_RS27185 ENOG410613R integral membrane protein, YccS YhfK family HEP84_RS27195 ENOG4105F2Z 3-oxoadipate enol-lactonase HEP84_RS27200 ENOG4107SQD Transcriptional regulator, GntR family HEP84_RS27235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS27260 ENOG4105CH2 amidohydrolase HEP84_RS27280 ENOG4105EUZ Beta-lactamase domain protein HEP84_RS27290 ENOG4105BZ4 penicillin-binding protein HEP84_RS27320 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP84_RS27330 ENOG4105VEQ Cold shock protein HEP84_RS27370 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HEP84_RS27420 ENOG4105D9P serine threonine protein kinase HEP84_RS27455 ENOG4108HCJ Hydrolase HEP84_RS27495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS27500 ENOG4105BZU Histidine kinase HEP84_RS27505 ENOG4105CMR udp-glucose 4-epimerase HEP84_RS27545 ENOG41082SX arsR family transcriptional regulator HEP84_RS27550 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEP84_RS27565 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP84_RS27655 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HEP84_RS27665 ENOG4105CSR polyphosphate kinase 2 HEP84_RS27670 ENOG4105BZP glycoside hydrolase 15-related HEP84_RS27675 ENOG4105C57 major facilitator superfamily HEP84_RS27680 ENOG4107TTQ Alpha beta hydrolase fold HEP84_RS27725 ENOG4108JQC penicillin-binding protein 1A HEP84_RS27780 ENOG4106F60 Histidine kinase HEP84_RS27785 ENOG4105ETX regulatoR HEP84_RS27845 ENOG4105EYW Ion transport protein HEP84_RS27875 ENOG4105DHP deoxycytidine triphosphate deaminase HEP84_RS27930 ENOG4105DF6 Fe-S oxidoreductase HEP84_RS27940 ENOG4105CFG Acts as a chaperone (By similarity) HEP84_RS27945 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP84_RS27950 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HEP84_RS27955 ENOG4105KNI merR family transcriptional Regulator HEP84_RS27970 ENOG4105DFW ABC transporter HEP84_RS28035 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP84_RS28065 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HEP84_RS28080 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HEP84_RS28085 ENOG4107RCW fructose-bisphosphate aldolase HEP84_RS28105 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HEP84_RS28135 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS28140 ENOG4105BZU Histidine kinase HEP84_RS28145 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS28155 ENOG4105DIM ABC transporter HEP84_RS28160 ENOG4105CIG ABC transporter HEP84_RS28175 ENOG4105CPD ethanolamine ammonia-lyase HEP84_RS28180 ENOG4107FQ9 ethanolamine ammonia-lyase HEP84_RS28190 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HEP84_RS28200 ENOG4105VEQ Cold shock protein HEP84_RS28205 ENOG4105CGH 5'-nucleotidase HEP84_RS28215 ENOG4108WYP Transcriptional regulator HEP84_RS28220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP84_RS28225 ENOG4108V4B ThiJ pfpI HEP84_RS28250 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HEP84_RS28255 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HEP84_RS28290 ENOG4105BZU Histidine kinase HEP84_RS28300 ENOG4105CFH Aspartokinase HEP84_RS28370 ENOG4105CRK lysyL-tRNA synthetase HEP84_RS28380 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS28385 ENOG4105WQT MbtH domain protein HEP84_RS28390 ENOG4105E2B Taurine dioxygenase HEP84_RS28395 ENOG4105CHR reductase HEP84_RS28400 ENOG4105EV8 ectoine hydroxylase HEP84_RS28460 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEP84_RS28465 ENOG4105EPW hflc protein HEP84_RS28540 ENOG4105BZ4 penicillin-binding protein HEP84_RS28575 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HEP84_RS28590 ENOG4105P8F nudix hydrolase HEP84_RS28605 ENOG4105D74 hydrolase HEP84_RS28615 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEP84_RS28620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP84_RS28625 ENOG4105CHH sulfate transporter HEP84_RS28685 ENOG4108I5C dEAD DEAH box helicase HEP84_RS28690 ENOG4105WN5 stage II sporulation protein HEP84_RS28695 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HEP84_RS28700 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HEP84_RS28725 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEP84_RS28730 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HEP84_RS28735 ENOG4105C6E dna polymerase iii HEP84_RS28785 ENOG4105C2M dna polymerase I HEP84_RS28810 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HEP84_RS28815 ENOG4105KDC 50s ribosomal protein l28 HEP84_RS28820 ENOG4105W0E 50S ribosomal protein L33 HEP84_RS28825 ENOG4105NRA 50s ribosomal protein l31 type b HEP84_RS28835 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEP84_RS28855 ENOG4105C26 Dehydrogenase HEP84_RS28870 ENOG4105CVK Glutamate decarboxylase HEP84_RS28880 ENOG4107TXC Transcriptional regulator HEP84_RS28885 ENOG41082VC UPF0145 protein HEP84_RS28890 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HEP84_RS28900 ENOG4105F0N pyrophosphate phospho-hydrolase HEP84_RS28915 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HEP84_RS28920 ENOG4108UGV hypoxanthine phosphoribosyltransferase HEP84_RS28930 ENOG4105EUJ GTP cyclohydrolase i HEP84_RS28940 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HEP84_RS28960 ENOG4105CRK lysyL-tRNA synthetase HEP84_RS28985 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS29000 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS29005 ENOG4105I1F Resistance protein HEP84_RS29030 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HEP84_RS29035 ENOG4108IYU L-aspartate oxidase HEP84_RS29045 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HEP84_RS29100 ENOG4105DR5 peptidase HEP84_RS29105 ENOG4108IG5 Transcriptional regulator HEP84_RS29115 ENOG4108FKE two-component system sensor kinase HEP84_RS29125 ENOG4108PYU two-component system response regulator HEP84_RS29130 ENOG41075QH Lipoprotein CseA HEP84_RS29135 ENOG4105NAF rna polymerase sigma factor HEP84_RS29150 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HEP84_RS29165 ENOG4108JWX HEP84_RS29170 ENOG4107R33 ppx gppa phosphatase HEP84_RS29175 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HEP84_RS29180 ENOG4105XEA Tetr family transcriptional regulator HEP84_RS29185 ENOG4105C01 Dihydroxy-acid dehydratase HEP84_RS29190 ENOG4108762 serine threonine protein kinase HEP84_RS29195 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HEP84_RS29215 ENOG4105CJ1 ABC, transporter HEP84_RS29225 ENOG4105II7 pyrroline-5-carboxylate reductase HEP84_RS29230 ENOG4105C31 Tryptophanyl-tRNA synthetase HEP84_RS29265 ENOG4105DGU Histone deacetylase HEP84_RS29270 ENOG4108XFF HEP84_RS29315 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HEP84_RS29320 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HEP84_RS29325 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HEP84_RS29330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HEP84_RS29335 ENOG4105D52 delta-aminolevulinic acid dehydratase HEP84_RS29355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS29370 ENOG4105C75 arginyL-tRNA synthetase HEP84_RS29375 ENOG4105DK7 lysyl-tRNA synthetase HEP84_RS29395 ENOG4105E0Y RtcB Protein HEP84_RS29415 ENOG4105KK4 UPF0060 membrane protein HEP84_RS29445 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP84_RS29450 ENOG4108UZX fmn reductase HEP84_RS29475 ENOG4105C0X amino acid HEP84_RS29480 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS29490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS29495 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS29515 ENOG4105D0M Protease HtpX homolog HEP84_RS29525 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP84_RS29535 ENOG4108ZJ4 polysaccharide deacetylase HEP84_RS29550 ENOG4105C0X amino acid HEP84_RS29560 ENOG4105D7N magnesium and cobalt transport protein CorA HEP84_RS29565 ENOG4107ZF2 Phosphatase HEP84_RS29570 ENOG4108QV3 biosynthesis protein HEP84_RS29590 ENOG4105D3Q Sugar transferase HEP84_RS29610 ENOG4105DQ4 alcohol dehydrogenase HEP84_RS29625 ENOG4105CAQ asparagine synthetase HEP84_RS29630 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP84_RS29635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS29645 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HEP84_RS29650 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HEP84_RS29660 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HEP84_RS29665 ENOG4108RH7 phosphoglycerate mutase HEP84_RS29685 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HEP84_RS29690 ENOG4105CRE cytochrome C HEP84_RS29740 ENOG4105YVS arsR family transcriptional regulator HEP84_RS29760 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEP84_RS29765 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HEP84_RS29770 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEP84_RS29780 ENOG4105DVY radical SAM domain protein HEP84_RS29805 ENOG4105CHR reductase HEP84_RS29810 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS29820 ENOG4105VEQ Cold shock protein HEP84_RS29825 ENOG4105EV6 Pfam:DUF178 HEP84_RS29840 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP84_RS29870 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS29890 ENOG41068JE domain protein HEP84_RS29900 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS29905 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEP84_RS29910 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS29920 ENOG4107QIZ NADH dehydrogenase HEP84_RS29925 ENOG4108IEH NADH dehydrogenase subunit g HEP84_RS29930 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HEP84_RS29935 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS29940 ENOG4105DF2 NADH dehydrogenase subunit j HEP84_RS29945 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS29950 ENOG4105D65 subunit l HEP84_RS29960 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS29970 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP84_RS29990 ENOG4105FDP GntR family transcriptional regulator HEP84_RS30005 ENOG4105CAY ferredoxin--nadp reductase HEP84_RS30015 ENOG4108FKH Transglycosylase SLT domain HEP84_RS30050 ENOG4105CJ1 ABC, transporter HEP84_RS30090 ENOG4105ECR NmrA family HEP84_RS30095 ENOG4105KVH Transcriptional regulator HEP84_RS30100 ENOG4105DQU oxidoreductase, subunit beta HEP84_RS30105 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HEP84_RS30125 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEP84_RS30130 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS30135 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEP84_RS30140 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HEP84_RS30155 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS30160 ENOG4105D65 subunit l HEP84_RS30165 ENOG4105C8S subunit m HEP84_RS30170 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP84_RS30175 ENOG4105D0M Protease HtpX homolog HEP84_RS30180 ENOG410901E Membrane HEP84_RS30200 ENOG4105Y3U Transglycosylase-associated protein HEP84_RS30205 ENOG4108VPT UPF0234 protein HEP84_RS30225 ENOG4105D17 glycoside hydrolase, family 3 domain protein HEP84_RS30260 ENOG4105WDJ 50S ribosomal protein L33 HEP84_RS30265 ENOG410900P UPF0336 protein HEP84_RS30285 ENOG4107R4N Cell wall formation (By similarity) HEP84_RS30290 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HEP84_RS30305 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP84_RS30325 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HEP84_RS30330 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HEP84_RS30335 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HEP84_RS30345 ENOG4105QCJ Lipoprotein HEP84_RS30350 ENOG4108VZM 50s ribosomal protein L10 HEP84_RS30355 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP84_RS30365 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP84_RS30370 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP84_RS30400 ENOG4107V6Q Cyclic nucleotide-binding domain HEP84_RS30405 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HEP84_RS30410 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HEP84_RS30415 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HEP84_RS30420 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEP84_RS30435 ENOG4106A3M Cytochrome p-450 HEP84_RS30460 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP84_RS30500 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HEP84_RS30505 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HEP84_RS30510 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HEP84_RS30515 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HEP84_RS30520 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HEP84_RS30525 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HEP84_RS30530 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HEP84_RS30535 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HEP84_RS30540 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HEP84_RS30545 ENOG41082SA 50s ribosomal protein l29 HEP84_RS30550 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HEP84_RS30555 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HEP84_RS30560 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HEP84_RS30565 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HEP84_RS30570 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HEP84_RS30580 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HEP84_RS30585 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HEP84_RS30590 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HEP84_RS30595 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HEP84_RS30600 ENOG410849U 50S ribosomal protein L30 HEP84_RS30605 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HEP84_RS30615 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HEP84_RS30625 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEP84_RS30630 ENOG41067V7 50S ribosomal protein L36 HEP84_RS30635 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HEP84_RS30640 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HEP84_RS30645 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP84_RS30650 ENOG4108ZT0 50S ribosomal protein l17 HEP84_RS30655 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HEP84_RS30680 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP84_RS30685 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HEP84_RS30695 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HEP84_RS30700 ENOG4108UJD 30S ribosomal protein S9 HEP84_RS30705 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HEP84_RS30715 ENOG4105CS9 pantothenic acid kinase HEP84_RS30720 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP84_RS30785 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEP84_RS30790 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HEP84_RS30795 ENOG4108097 ATP-binding protein HEP84_RS30820 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HEP84_RS30855 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS30890 ENOG4105CHP RNA polymerase HEP84_RS30910 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HEP84_RS30915 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HEP84_RS30925 ENOG4105EMU Dehydrogenase HEP84_RS30935 ENOG4105DND Transcriptional regulator HEP84_RS30940 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP84_RS30950 ENOG4108MMM RNA Polymerase HEP84_RS30960 ENOG4107QVP Dehydrogenase HEP84_RS30970 ENOG4107QQG Dehydrogenase HEP84_RS30975 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEP84_RS30995 ENOG4107TPY serine threonine protein kinase HEP84_RS31000 ENOG4105D9P serine threonine protein kinase HEP84_RS31005 ENOG4107TPY serine threonine protein kinase HEP84_RS31020 ENOG4105C26 Dehydrogenase HEP84_RS31090 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS31125 ENOG4105DR5 peptidase HEP84_RS31155 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP84_RS31165 ENOG4105DEG Vwa containing coxe family protein HEP84_RS31180 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEP84_RS31210 ENOG4105DC1 bifunctional purine biosynthesis protein purh HEP84_RS31230 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEP84_RS31250 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HEP84_RS31270 ENOG410645S MarR family Transcriptional regulator HEP84_RS31285 ENOG4108IJ7 Glycine betaine HEP84_RS31290 ENOG4108HQS Glycine betaine HEP84_RS31305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS31310 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS31320 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS31330 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HEP84_RS31340 ENOG4108ES0 acetoacetyl-CoA synthetase HEP84_RS31350 ENOG4108ZFD Antibiotic biosynthesis monooxygenase HEP84_RS31375 ENOG4106032 Glutathionylspermidine synthase HEP84_RS31380 ENOG4105C8Y Acetylornithine aminotransferase HEP84_RS31385 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP84_RS31395 ENOG4105C31 Tryptophanyl-tRNA synthetase HEP84_RS31430 ENOG4107H3J ribonuclease HEP84_RS31445 ENOG4107RN3 metallophosphoesterase HEP84_RS31450 ENOG4108EVY peptide transport periplasmic protein HEP84_RS31470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS31475 ENOG4105EYF MMPL domain protein HEP84_RS31530 ENOG4108J01 L-aspartate oxidase HEP84_RS31550 ENOG4105E2D ec 3.2.1.52 HEP84_RS31590 ENOG4105GFR rna polymerase sigma factor HEP84_RS31600 ENOG4108MMM RNA Polymerase HEP84_RS31625 ENOG4108NIW Leucine export protein LeuE HEP84_RS31645 ENOG4105K64 Glycosyl transferase, family 2 HEP84_RS31655 ENOG4105F0R Cytidylyltransferase HEP84_RS31660 ENOG4105D2T synthase HEP84_RS31680 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS31685 ENOG4105K7W phage-related replication protein HEP84_RS31735 ENOG4107RM1 amidohydrolase HEP84_RS31740 ENOG4105DIH basic membrane HEP84_RS31745 ENOG4105DIH basic membrane HEP84_RS31750 ENOG4108JQ9 ABC transporter HEP84_RS31795 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEP84_RS31800 ENOG4105D94 Major Facilitator Superfamily HEP84_RS31805 ENOG4107RSM transcriptional regulator HEP84_RS31815 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP84_RS31840 ENOG41065SU Two-component system sensor kinase HEP84_RS31845 ENOG4108KXV response regulator HEP84_RS31850 ENOG4105NAF rna polymerase sigma factor HEP84_RS31865 ENOG4105C26 Dehydrogenase HEP84_RS31870 ENOG4105C26 Dehydrogenase HEP84_RS31875 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HEP84_RS31890 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HEP84_RS31920 ENOG4108JIK carboxylase HEP84_RS31930 ENOG4107WR6 Maf-like protein HEP84_RS31945 ENOG4105D8K carboxyl transferase HEP84_RS31955 ENOG4108QER Adenylate cyclase HEP84_RS31965 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS31970 ENOG4105KDM Diguanylate cyclase with gaf sensor HEP84_RS31975 ENOG4105C84 Histidine ammonia-lyase HEP84_RS31980 ENOG4105VEQ Cold shock protein HEP84_RS32015 ENOG4105C19 ABC transporter HEP84_RS32035 ENOG4105DQ4 alcohol dehydrogenase HEP84_RS32040 ENOG4105TVJ transport system, permease HEP84_RS32045 ENOG4105DQ5 transport system permease protein HEP84_RS32055 ENOG4107R16 Multicopper oxidase HEP84_RS32090 ENOG4105NPE arsR family transcriptional regulator HEP84_RS32095 ENOG4105CHR reductase HEP84_RS32160 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HEP84_RS32185 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEP84_RS32190 ENOG4105C7B Threonine dehydratase HEP84_RS32230 ENOG4105EW6 flavin reductase domain protein, FMN-binding HEP84_RS32235 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEP84_RS32245 ENOG4105T1M mycothiol conjugate amidase mca HEP84_RS32275 ENOG4105C7Z Conserved Protein HEP84_RS32310 ENOG4105C57 major facilitator superfamily HEP84_RS32320 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HEP84_RS32335 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEP84_RS32350 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HEP84_RS32400 ENOG4105CHM Aminotransferase HEP84_RS32430 ENOG4108FUF Transcriptional regulator, IclR family HEP84_RS32435 ENOG4105KME endoribonuclease L-psp HEP84_RS32440 ENOG4105C6Z Gluconate HEP84_RS32500 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid HEP84_RS32535 ENOG4107QMS site-determining protein HEP84_RS32565 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS32585 ENOG4107QKZ Ompa motb domain protein HEP84_RS32590 ENOG4105NAE bifunctional deaminase-reductase domain protein HEP84_RS32620 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HEP84_RS32625 ENOG4108IAB Phoh family HEP84_RS32640 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS32645 ENOG4105D3R alkyl hydroperoxide reductase HEP84_RS32660 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS32675 ENOG4105BZ4 penicillin-binding protein HEP84_RS32680 ENOG4105CH6 catalase HEP84_RS32695 ENOG4105C9Q fumarate hydratase class II HEP84_RS32710 ENOG4107GFK fumarate HEP84_RS32720 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP84_RS32735 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP84_RS32740 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEP84_RS32745 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEP84_RS32750 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HEP84_RS32765 ENOG4105C3G gtp-binding protein HEP84_RS32775 ENOG4105EC2 ftsk spoIIIe HEP84_RS32830 ENOG4105CHR reductase HEP84_RS32900 ENOG4105E33 succinate dehydrogenase HEP84_RS32905 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEP84_RS32925 ENOG4105CI3 gtp-binding protein typa HEP84_RS32940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP84_RS32950 ENOG4108JQ7 (ABC) transporter HEP84_RS32955 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HEP84_RS32960 ENOG4108J59 Extracellular solute-binding protein, family 5 HEP84_RS32965 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP84_RS32970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP84_RS32975 ENOG4105C3U ABC transporter HEP84_RS32980 ENOG4108JQ7 (ABC) transporter HEP84_RS32995 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP84_RS33015 ENOG4108M15 ABC transporter HEP84_RS33025 ENOG4108ZGX Histidine kinase HEP84_RS33030 ENOG4108S01 response regulator HEP84_RS33045 ENOG4108Z4U Ferredoxin HEP84_RS33065 ENOG4107R4C succinyl-diaminopimelate desuccinylase HEP84_RS33070 ENOG4108URH decarboxylase HEP84_RS33075 ENOG4105EEI dihydropteroate synthase HEP84_RS33085 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HEP84_RS33090 ENOG4105CGU Enoyl-CoA hydratase HEP84_RS33105 ENOG4105DU6 RNA polymerase HEP84_RS33115 ENOG4105C0H protease HEP84_RS33120 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEP84_RS33145 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HEP84_RS33155 ENOG4105D7N magnesium and cobalt transport protein CorA HEP84_RS33165 ENOG4105DXB Major Facilitator superfamily HEP84_RS33180 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HEP84_RS33195 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HEP84_RS33240 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP84_RS33245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP84_RS33310 ENOG4105C4R Atp-dependent dna helicase HEP84_RS33315 ENOG4107QSE Dipeptidase HEP84_RS33340 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP84_RS33410 ENOG41063PX domain protein HEP84_RS33420 ENOG4105DJZ UPF0182 protein HEP84_RS33450 ENOG4105C2X Arabinose 5-phosphate isomerase HEP84_RS33455 ENOG4107TK4 histidinol-phosphate phosphatase HEP84_RS33475 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HEP84_RS33485 ENOG4108RAV Conserved protein HEP84_RS33495 ENOG4105EMN RNA polymerase sigma factor HEP84_RS33500 ENOG4105WMN AntiSigma factor HEP84_RS33520 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP84_RS33530 ENOG41068W2 Cytochrome p-450 HEP84_RS33550 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP84_RS33555 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP84_RS33575 ENOG4105FDP GntR family transcriptional regulator HEP84_RS33595 ENOG4105D17 glycoside hydrolase, family 3 domain protein HEP84_RS33600 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HEP84_RS33605 ENOG4107SM8 Adenylate Guanylate cyclase HEP84_RS33610 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP84_RS33625 ENOG4105CBD Diacylglycerol kinase HEP84_RS33670 ENOG4105ESN nucleotide-binding protein HEP84_RS33725 ENOG4108VEQ Superoxide dismutase HEP84_RS33745 ENOG4105CDA abc transporter atp-binding protein HEP84_RS33760 ENOG4105C6K Malic enzyme HEP84_RS33765 ENOG4105CB2 alcohol dehydrogenase HEP84_RS33800 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEP84_RS33805 ENOG4105EB3 Histidine kinase HEP84_RS33810 ENOG4108PYU two-component system response regulator HEP84_RS33815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP84_RS33840 ENOG4105CBG Sulfatase HEP84_RS33845 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HEP84_RS33905 ENOG4108IG5 Transcriptional regulator HEP84_RS33930 ENOG4108PJD permease HEP84_RS33935 ENOG4105CJN penicillin-binding protein HEP84_RS33940 ENOG4107QHZ cell cycle protein HEP84_RS33970 ENOG4105DQE DNA ligase HEP84_RS33975 ENOG4105FDF Could be involved in DNA repair (By similarity) HEP84_RS33980 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEP84_RS34130 ENOG4105CZE histidine utilization repressor HEP84_RS34195 ENOG4105C75 arginyL-tRNA synthetase HEP84_RS34200 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HEP84_RS34205 ENOG4105D6E homoserine dehydrogenase HEP84_RS34210 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HEP84_RS34215 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HEP84_RS34225 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP84_RS34230 ENOG4108KGH TRANSCRIPTIONal HEP84_RS34235 ENOG4105VFB Binds the 23S rRNA (By similarity) HEP84_RS34240 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HEP84_RS34245 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP84_RS34255 ENOG4107ZF2 Phosphatase HEP84_RS34260 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP84_RS34265 ENOG4105ESV Glycosyl transferase, family 4 HEP84_RS34270 ENOG4105Z3P ATP synthase HEP84_RS34280 ENOG4105ZA1 atp synthase HEP84_RS34285 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HEP84_RS34290 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HEP84_RS34295 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HEP84_RS34300 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HEP84_RS34305 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HEP84_RS34310 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HEP84_RS34325 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS34330 ENOG4105BZU Histidine kinase HEP84_RS34335 ENOG4105IIP Membrane HEP84_RS34355 ENOG410630P Transcriptional regulator HEP84_RS34360 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP84_RS34375 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HEP84_RS34420 ENOG4105CJ1 ABC, transporter HEP84_RS34440 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS34475 ENOG4105VCH membrane HEP84_RS34515 ENOG4105WX6 Membrane HEP84_RS34560 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEP84_RS34565 ENOG4105C6K Malic enzyme HEP84_RS34570 ENOG4105CTQ phosphohexokinase HEP84_RS34605 ENOG4108MRH transcriptional regulatory protein HEP84_RS34615 ENOG4105D7V transposase HEP84_RS34620 ENOG4105CK2 sodium dicarboxylate symporter HEP84_RS34630 ENOG4105C57 major facilitator superfamily HEP84_RS34640 ENOG4107SET aldo keto reductase HEP84_RS34670 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HEP84_RS34675 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HEP84_RS34685 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HEP84_RS34690 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP84_RS34695 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEP84_RS34715 ENOG4105BZ1 (ABC) transporter HEP84_RS34720 ENOG4105BZ1 (ABC) transporter HEP84_RS34725 ENOG4105BZ1 (ABC) transporter HEP84_RS34730 ENOG4105BZ1 (ABC) transporter HEP84_RS34735 ENOG4105CJ1 ABC, transporter HEP84_RS34745 ENOG4105BZU Histidine kinase HEP84_RS34750 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS34760 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HEP84_RS34765 ENOG41069FZ L,D-transpeptidase catalytic domain HEP84_RS34815 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HEP84_RS34845 ENOG4105EJQ L-serine dehydratase HEP84_RS34850 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP84_RS34855 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HEP84_RS34860 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HEP84_RS34880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP84_RS34900 ENOG4108JQ7 (ABC) transporter HEP84_RS34915 ENOG4105EN6 Membrane HEP84_RS34935 ENOG4105D29 Helix-turn-helix type 11 domain protein HEP84_RS34975 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HEP84_RS34985 ENOG4108URH decarboxylase HEP84_RS34990 ENOG4105EMU Dehydrogenase HEP84_RS35000 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP84_RS35005 ENOG4105BZU Histidine kinase HEP84_RS35010 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HEP84_RS35015 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HEP84_RS35025 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HEP84_RS35030 ENOG4105EYF MMPL domain protein HEP84_RS35035 ENOG4105D9U N-acetyltransferase HEP84_RS35060 ENOG4105CPC Aldo Keto reductase HEP84_RS35085 ENOG4108ZP8 Acetolactate synthase small subunit HEP84_RS35090 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HEP84_RS35100 ENOG4107SM8 Adenylate Guanylate cyclase HEP84_RS35105 ENOG4105C57 major facilitator superfamily HEP84_RS35115 ENOG4105T0Z Conserved Protein HEP84_RS35130 ENOG4105C26 Dehydrogenase HEP84_RS35145 ENOG4105CGS Alpha-glucosidase HEP84_RS35155 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP84_RS35165 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HEP84_RS35170 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEP84_RS35195 ENOG4105CQM Urea amidohydrolase subunit alpha HEP84_RS35200 ENOG4105DWY Agmatine deiminase HEP84_RS35215 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP84_RS35225 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP84_RS35245 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS35255 ENOG4105CJ1 ABC, transporter HEP84_RS35290 ENOG4105BZU Histidine kinase HEP84_RS35295 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS35300 ENOG4108YYC ycei family HEP84_RS35305 ENOG4105D8K carboxyl transferase HEP84_RS35325 ENOG4105GWZ Roadblock lc7 family protein HEP84_RS35345 ENOG4105GWZ Roadblock lc7 family protein HEP84_RS35360 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HEP84_RS35365 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HEP84_RS35410 ENOG41069M3 Transcriptional regulator HEP84_RS35415 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEP84_RS35420 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEP84_RS35430 ENOG4105K70 DNA-binding protein HEP84_RS35450 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP84_RS35455 ENOG4105CPF Cell wall formation (By similarity) HEP84_RS35485 ENOG4105VB9 50S ribosomal protein l28 HEP84_RS35490 ENOG4105DP4 dak2 domain fusion protein ylov HEP84_RS35505 ENOG4105CB5 ATP-dependent DNA helicase recG HEP84_RS35510 ENOG4106H78 methyltransferase HEP84_RS35515 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HEP84_RS35530 ENOG41084BZ 50S ribosomal protein L32 HEP84_RS35535 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HEP84_RS35540 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HEP84_RS35545 ENOG4105KVH Transcriptional regulator HEP84_RS35555 ENOG4105K4I Scp-like extracellular HEP84_RS35560 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HEP84_RS35615 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HEP84_RS35625 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEP84_RS35635 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HEP84_RS35645 ENOG4105K5M 30s ribosomal protein S16 HEP84_RS35650 ENOG41082KU UPF0109 protein HEP84_RS35655 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HEP84_RS35660 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HEP84_RS35665 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HEP84_RS35675 ENOG4107QYR Signal peptidase i HEP84_RS35685 ENOG4107QYR Signal peptidase i HEP84_RS35690 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HEP84_RS35700 ENOG41080R2 UPF0102 protein HEP84_RS35720 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A HEP84_RS35745 ENOG4105D7K pfkb domain protein HEP84_RS35750 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HEP84_RS35835 ENOG4105ZXU NLP P60 protein HEP84_RS35940 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HEP84_RS36055 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS36070 ENOG4105CE9 30S ribosomal protein S2 HEP84_RS36075 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HEP84_RS36080 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HEP84_RS36085 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HEP84_RS36090 ENOG4105KNE Phosphatidate cytidylyltransferase HEP84_RS36110 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HEP84_RS36120 ENOG4108I5D sulfate abc transporter HEP84_RS36155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS36160 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP84_RS36170 ENOG4105C26 Dehydrogenase HEP84_RS36205 ENOG4105CPQ Dehydrogenase HEP84_RS36240 ENOG4105EW9 transcriptional regulator AsnC family HEP84_RS36250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS36270 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP84_RS36285 ENOG4105C26 Dehydrogenase HEP84_RS36295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS36300 ENOG4105F38 ABC transporter, permease HEP84_RS36305 ENOG4105D38 putrescine abc transporter HEP84_RS36310 ENOG4105CJP fad dependent oxidoreductase HEP84_RS36340 ENOG4105G9B Transcriptional regulator HEP84_RS36340 ENOG4105G9B Transcriptional regulator HEP84_RS36360 ENOG4105E0S extracellular solute-binding protein family 1 HEP84_RS36370 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HEP84_RS36405 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS36425 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP84_RS36435 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HEP84_RS36440 ENOG4105DZP Membrane-associated zinc metalloprotease HEP84_RS36445 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HEP84_RS36460 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HEP84_RS36490 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HEP84_RS36505 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HEP84_RS36530 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HEP84_RS36535 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HEP84_RS36555 ENOG4105C3U ABC transporter HEP84_RS36560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP84_RS36565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP84_RS36570 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HEP84_RS36600 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HEP84_RS36675 ENOG4105EC2 ftsk spoIIIe HEP84_RS36690 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HEP84_RS36695 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HEP84_RS36700 ENOG4105C1V Peptidase, M16 HEP84_RS36705 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HEP84_RS36730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP84_RS36735 ENOG4105CN5 Metallo-Beta-Lactamase HEP84_RS36775 ENOG4105BZU Histidine kinase HEP84_RS36780 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HEP84_RS36785 ENOG4107QZI cell division protein FtsK HEP84_RS36795 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HEP84_RS36805 ENOG4105CEV competence damage-inducible protein HEP84_RS36810 ENOG4105WBV Transcriptional regulator HEP84_RS36815 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HEP84_RS36820 ENOG4105CHR reductase HEP84_RS36825 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HEP84_RS36830 ENOG4107QRT dEAD DEAH box helicase HEP84_RS36860 ENOG4105DSF transport protein HEP84_RS36870 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HEP84_RS36905 ENOG4105DRP amino acid AbC transporter HEP84_RS36910 ENOG4108Q1T ABC transporter HEP84_RS36915 ENOG4107UBR Extracellular solute-binding protein family 3 HEP84_RS36920 ENOG4105CDA abc transporter atp-binding protein HEP84_RS36925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS36930 ENOG4105EB3 Histidine kinase HEP84_RS36955 ENOG4105BZU Histidine kinase HEP84_RS36960 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS36995 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HEP84_RS37015 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HEP84_RS37025 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HEP84_RS37030 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEP84_RS37040 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HEP84_RS37090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS37095 ENOG4105ENE Histidine kinase HEP84_RS37100 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS37105 ENOG4105F0K SARP family transcriptional regulator HEP84_RS37125 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS37130 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS37175 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS37210 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP84_RS37215 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HEP84_RS37220 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP84_RS37255 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HEP84_RS37270 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP84_RS37285 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEP84_RS37290 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS37295 ENOG4105DRR Transcriptional regulator, GntR family HEP84_RS37300 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS37305 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP84_RS37315 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP84_RS37330 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS37340 ENOG4107QN1 sodium solute HEP84_RS37345 ENOG4108V9W transcriptional regulatory protein HEP84_RS37355 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HEP84_RS37365 ENOG4108MRH transcriptional regulatory protein HEP84_RS37380 ENOG4105BZN citrate synthase HEP84_RS37385 ENOG4105BZN citrate synthase HEP84_RS37400 ENOG4107QRP cobalamin biosynthesis protein CobW HEP84_RS37405 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP84_RS37425 ENOG4105DRR Transcriptional regulator, GntR family HEP84_RS37430 ENOG410849S phosphocarrier protein (HPr) HEP84_RS37450 ENOG4107W53 thymidine kinase HEP84_RS37485 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HEP84_RS37500 ENOG4105F44 Two component transcriptional regulator, winged helix family HEP84_RS37505 ENOG4106F60 Histidine kinase HEP84_RS37530 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HEP84_RS37545 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS37575 ENOG4107VEG TrkA-N domain protein HEP84_RS37580 ENOG4105C0X amino acid HEP84_RS37585 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HEP84_RS37600 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HEP84_RS37605 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEP84_RS37615 ENOG4105K64 Glycosyl transferase, family 2 HEP84_RS37625 ENOG4105EQQ protein containing aminopeptidase domain HEP84_RS37640 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HEP84_RS37650 ENOG4105E2K Glycosyl transferase (Group 1 HEP84_RS37670 ENOG4107RRD Dehydrogenase HEP84_RS37675 ENOG4105CAQ asparagine synthetase HEP84_RS37695 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP84_RS37700 ENOG4105D3Q Sugar transferase HEP84_RS37725 ENOG4105NAE bifunctional deaminase-reductase domain protein HEP84_RS37735 ENOG4105MHT Transcriptional regulator, ARSR family HEP84_RS37765 ENOG4105EYF MMPL domain protein HEP84_RS37775 ENOG4105F4R Transcriptional regulator mode HEP84_RS37780 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP84_RS37805 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP84_RS37815 ENOG4107S1Q Phosphatase HEP84_RS37830 ENOG4105CEU Arginine dihydrolase HEP84_RS37835 ENOG4105DBV ornithine carbamoyltransferase HEP84_RS37840 ENOG4105CUB amino acid HEP84_RS37850 ENOG4105CGU Enoyl-CoA hydratase HEP84_RS37900 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HEP84_RS37915 ENOG4107QM5 aconitate hydratase HEP84_RS37925 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP84_RS37940 ENOG4105BZU Histidine kinase HEP84_RS37950 ENOG4105CWX Alpha-1,2-mannosidase HEP84_RS37960 ENOG4105CHR reductase HEP84_RS37985 ENOG4105E2R ROK family HEP84_RS37990 ENOG4105DFW ABC transporter HEP84_RS37995 ENOG4105C2J ABC transporter HEP84_RS38000 ENOG4108HWW ABC transporter HEP84_RS38005 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HEP84_RS38010 ENOG4105CUB amino acid HEP84_RS38040 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP84_RS38045 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS38050 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HEP84_RS38065 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HEP84_RS38080 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HEP84_RS38090 ENOG4105C1Q protoporphyrinogen oxidase HEP84_RS38095 ENOG4107JTW chlorite dismutase HEP84_RS38115 ENOG4105E18 UPF0276 protein HEP84_RS38160 ENOG4105C22 threonyL-tRNA synthetase HEP84_RS38175 ENOG4107B2H carbonic anhydrase HEP84_RS38200 ENOG4105DFU Cell wall formation (By similarity) HEP84_RS38205 ENOG4105E0X reductase HEP84_RS38230 ENOG4105BZU Histidine kinase HEP84_RS38265 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HEP84_RS38280 ENOG4105EDW glycosyl transferase, family 39 HEP84_RS38305 ENOG4105DHQ Histidine kinase HEP84_RS38325 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS38330 ENOG4108ZGX Histidine kinase HEP84_RS38400 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP84_RS38430 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HEP84_RS38435 ENOG4105DUM transcriptional regulator, lysR family HEP84_RS38440 ENOG4105C0H protease HEP84_RS38475 ENOG4105ZSU inhibitor HEP84_RS38565 ENOG4107S5I aldo keto reductase HEP84_RS38585 ENOG4105MC2 DSBA oxidoreductase HEP84_RS38600 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP84_RS38605 ENOG4108IY8 ABC, transporter HEP84_RS38635 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HEP84_RS38660 ENOG4107RR1 TRANSCRIPTIONal HEP84_RS38665 ENOG4105CSU acyl-Coa dehydrogenase HEP84_RS38680 ENOG4105E7U AraC family transcriptional regulator HEP84_RS38700 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HEP84_RS38720 ENOG4105DSG hydrolase family 43 HEP84_RS38740 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS38750 ENOG4105DKQ ROK family HEP84_RS38765 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP84_RS38770 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HEP84_RS38800 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS38825 ENOG4105EBR Carboxylesterase HEP84_RS38840 ENOG4108J5H Homocysteine s-methyltransferase HEP84_RS38995 ENOG4105XPP Protein of unknown function (DUF1275) HEP84_RS39000 ENOG4105CHJ isochorismatase hydrolase HEP84_RS39030 ENOG4105CJ1 ABC, transporter HEP84_RS39035 ENOG4105EQ0 Major Facilitator superfamily HEP84_RS39045 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HEP84_RS39065 ENOG4105QE3 oxidoreductase HEP84_RS39080 ENOG4105CYP glycoside hydrolase, family HEP84_RS39160 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HEP84_RS39170 ENOG4105EC3 peptidase S51, dipeptidase E HEP84_RS39210 ENOG4105C7K acetolactate synthase HEP84_RS39230 ENOG4105DRR Transcriptional regulator, GntR family HEP84_RS39260 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HEP84_RS39265 ENOG4105C7N Xanthine uracil vitamin C permease HEP84_RS39295 ENOG4108ZJ4 polysaccharide deacetylase HEP84_RS39300 ENOG4105DDC Oxidoreductase domain protein HEP84_RS39310 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP84_RS39315 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HEP84_RS39330 ENOG4105F27 Major Facilitator HEP84_RS39345 ENOG4108XEP Alpha Beta Hydrolase Fold protein HEP84_RS39350 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP84_RS39370 ENOG4105CJ2 (LipO)protein HEP84_RS39385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS39390 ENOG4105BZU Histidine kinase HEP84_RS39435 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HEP84_RS39440 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HEP84_RS39445 ENOG4107SVN transposase HEP84_RS39450 ENOG4105EF1 ribulokinase HEP84_RS39470 ENOG4105DME alpha-galactosidase HEP84_RS39520 ENOG4105G9B Transcriptional regulator HEP84_RS39525 ENOG4107FQ9 ethanolamine ammonia-lyase HEP84_RS39535 ENOG4105Q56 cytochrome P450 HEP84_RS39545 ENOG4105C84 Histidine ammonia-lyase HEP84_RS39550 ENOG4105C54 Major Facilitator superfamily HEP84_RS39560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP84_RS39580 ENOG4105ETX regulatoR HEP84_RS39620 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEP84_RS39625 ENOG4105D7N magnesium and cobalt transport protein CorA HEP84_RS39635 ENOG410829K Lysine exporter protein (Lyse ygga) HEP84_RS39640 ENOG4107RSM transcriptional regulator HEP84_RS39650 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP84_RS39655 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HEP84_RS39665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP84_RS39670 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS39680 ENOG41060W2 glyoxylate carboligase HEP84_RS39690 ENOG4105CH6 catalase HEP84_RS39695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP84_RS39700 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HEP84_RS39720 ENOG4105VT2 5-hydroxyisourate hydrolase HEP84_RS39730 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP84_RS39750 ENOG4105KVH Transcriptional regulator HEP84_RS39765 ENOG4108ZM9 phosphoglycerate mutase HEP84_RS39770 ENOG4105CHM Aminotransferase HEP84_RS39815 ENOG4108SGK Tetr family transcriptional regulator HEP84_RS39885 ENOG4105ERH Fumarylacetoacetate hydrolase HEP84_RS39935 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HEP84_RS39965 ENOG4108VB1 regulatoR HEP84_RS39980 ENOG4105D9G High-affinity HEP84_RS40045 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HEP84_RS40085 ENOG4107R9S Malate synthase HEP84_RS40100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP84_RS40115 ENOG4107HP6 Transcriptional regulator HEP84_RS40130 ENOG4105D7N magnesium and cobalt transport protein CorA HEP84_RS40145 ENOG4105CPC Aldo Keto reductase HEP84_RS40150 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS40160 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP84_RS40180 ENOG4105CNN ABC, transporter HEP84_RS40185 ENOG4105C2J ABC transporter HEP84_RS40190 ENOG4105DKQ ROK family HEP84_RS40200 ENOG4105C0D helicase HEP84_RS40240 ENOG4105CPC Aldo Keto reductase HEP84_RS40265 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HEP84_RS40290 ENOG4107RCI amp-dependent synthetase and ligase HEP84_RS40300 ENOG4105CQF Transcriptional regulator HEP84_RS40315 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HEP84_RS40320 ENOG4105E8R UPF0173 metal-dependent hydrolase HEP84_RS40335 ENOG4105CDA abc transporter atp-binding protein HEP84_RS40345 ENOG4105EAD ABC transporter HEP84_RS40350 ENOG4105DRP amino acid AbC transporter HEP84_RS40365 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HEP84_RS40390 ENOG4105C8Y Acetylornithine aminotransferase HEP84_RS40405 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HEP84_RS40415 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HEP84_RS40425 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEP84_RS40435 ENOG4105BZU Histidine kinase HEP84_RS40440 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS40450 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HEP84_RS40455 ENOG4108YYQ gCN5-related N-acetyltransferase HEP84_RS40495 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HEP84_RS40535 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP84_RS40560 ENOG4105ECY inositol monophosphatase HEP84_RS40575 ENOG4108UVJ appr-1-p processing domain protein HEP84_RS40600 ENOG4105ETX regulatoR HEP84_RS40605 ENOG4105EB3 Histidine kinase HEP84_RS40625 ENOG4107QIZ NADH dehydrogenase HEP84_RS40675 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEP84_RS40680 ENOG4106NZI LysR family Transcriptional regulator HEP84_RS40690 ENOG4105CBP Major Facilitator HEP84_RS40705 ENOG41060BG Tetr family transcriptional regulator HEP84_RS40745 ENOG4106F60 Histidine kinase HEP84_RS40755 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP84_RS40785 ENOG41066UM arsR family transcriptional regulator HEP84_RS40805 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HEP84_RS40810 ENOG4105C2U cobyrinic Acid a,c-diamide synthase HEP84_RS40845 ENOG4105BZW Glycerate kinase HEP84_RS40855 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HEP84_RS40860 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS40870 ENOG4105CI0 Citrate lyase HEP84_RS40890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP84_RS40900 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP84_RS40910 ENOG4106JDR secreted HEP84_RS40930 ENOG4108Q50 Histidine kinase HEP84_RS40975 ENOG4108ME1 Peptidase M55 D-aminopeptidase HEP84_RS40980 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEP84_RS40990 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HEP84_RS41015 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEP84_RS41025 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS41035 ENOG4105C5H ABC transporter HEP84_RS41125 ENOG4105CFG Acts as a chaperone (By similarity) HEP84_RS41150 ENOG410842T Pterin carbinolamine dehydratase HEP84_RS41160 ENOG4105D7V transposase HEP84_RS41165 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS41180 ENOG4105D29 Helix-turn-helix type 11 domain protein HEP84_RS41190 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HEP84_RS41200 ENOG4105CYP glycoside hydrolase, family HEP84_RS41210 ENOG41065HY 1,4-beta-cellobiosidase HEP84_RS41230 ENOG4108HMN Caspase domain HEP84_RS41245 ENOG4105CV8 reductase HEP84_RS41270 ENOG4105F5H Glycosyl Hydrolase Family 88 HEP84_RS41280 ENOG4106UDK Cellulose-binding, family II HEP84_RS41335 ENOG4105FDF Could be involved in DNA repair (By similarity) HEP84_RS41350 ENOG4105DUM transcriptional regulator, lysR family HEP84_RS41355 ENOG4105DHU Bile acid HEP84_RS41365 ENOG4108478 ec 3.2.1.18 HEP84_RS41375 ENOG4108VHT MarR family transcriptional regulator HEP84_RS41380 ENOG4105D3W isochorismatase HEP84_RS41385 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP84_RS41390 ENOG4106NZI LysR family Transcriptional regulator HEP84_RS41395 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HEP84_RS41410 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP84_RS41415 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEP84_RS41455 ENOG4105DKQ ROK family HEP84_RS41460 ENOG4105C2J ABC transporter HEP84_RS41465 ENOG4105CNN ABC, transporter HEP84_RS41470 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP84_RS41540 ENOG4105FCD Major Facilitator HEP84_RS41560 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEP84_RS41570 ENOG4105C26 Dehydrogenase HEP84_RS41620 ENOG4105CBC glutamate synthase HEP84_RS41675 ENOG4105K5B UPF0225 protein HEP84_RS41725 ENOG4105EMU Dehydrogenase HEP84_RS41740 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP84_RS41750 ENOG4108MIC Mg-protoporphyrin IX methyl transferase HEP84_RS41760 ENOG4105D7V transposase HEP84_RS41780 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HEP84_RS41840 ENOG4105CPQ Dehydrogenase HEP84_RS41855 ENOG4105CPQ Dehydrogenase HEP84_RS41865 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEP84_RS41895 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HEP84_RS41900 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HEP84_RS41905 ENOG4105C7W Xanthine dehydrogenase HEP84_RS41915 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP84_RS41930 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase HEP84_RS41960 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HEP84_RS41965 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HEP84_RS41975 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HEP84_RS41995 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HEP84_RS42000 ENOG4105VF7 tolerance protein HEP84_RS42015 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HEP84_RS42075 ENOG4107GJV short-chain dehydrogenase reductase HEP84_RS42095 ENOG4105NRA 50s ribosomal protein l31 type b HEP84_RS42105 ENOG4105BZU Histidine kinase HEP84_RS42110 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS42120 ENOG4107HY1 Dehydrogenase HEP84_RS42155 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP84_RS42160 ENOG4105CHR reductase HEP84_RS42170 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP84_RS42185 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP84_RS42200 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS42215 ENOG4108M9J MaoC like domain protein HEP84_RS42230 ENOG4105CPQ Dehydrogenase HEP84_RS42240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP84_RS42255 ENOG4106A3M Cytochrome p-450 HEP84_RS42310 ENOG4108YYC ycei family HEP84_RS42320 ENOG4105DRP amino acid AbC transporter HEP84_RS42325 ENOG4105CDA abc transporter atp-binding protein HEP84_RS42355 ENOG4105DEN Luciferase family HEP84_RS42365 ENOG4108NNI Beta-lactamase domain-containing protein HEP84_RS42415 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP84_RS42420 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEP84_RS42440 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP84_RS42455 ENOG4107QJN gtp cyclohydrolase ii HEP84_RS42495 ENOG410905P Pyridoxamine 5-phosphate HEP84_RS42505 ENOG4105CSH Transporter HEP84_RS42520 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HEP84_RS42535 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP84_RS42540 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP84_RS42545 ENOG4107QP8 phosphohexose isomerase HEP84_RS42560 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEP84_RS42595 ENOG4105CHR reductase HEP84_RS42620 ENOG41088CQ domain protein HEP84_RS42625 ENOG4105CNT hydrolase family 2 HEP84_RS42630 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HEP84_RS42645 ENOG4108MGF sugar kinase HEP84_RS42650 ENOG4105E98 transcriptional regulator DeoR family HEP84_RS42655 ENOG4105F8D glycoside hydrolase family 4 HEP84_RS42675 ENOG4105D7V transposase HEP84_RS42685 ENOG4106UDK Cellulose-binding, family II HEP84_RS42750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP84_RS42755 ENOG4107TYH extracellular solute-binding protein family 1 HEP84_RS42760 ENOG4105D81 ABC transporter, permease HEP84_RS42765 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HEP84_RS42780 ENOG4105EUB pirin domain protein HEP84_RS42840 ENOG4105CHJ isochorismatase hydrolase HEP84_RS42845 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEP84_RS42850 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP84_RS42855 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEP84_RS42915 ENOG4105KF0 sporulation and cell division protein, SsgA HEP84_RS42950 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS42955 ENOG4105D2B acyl-CoA dehydrogenase HEP84_RS42965 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP84_RS42985 ENOG4108PVQ transcriptional regulator HEP84_RS42990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP84_RS43020 ENOG4105VU5 Resolvase domain-containing protein HEP84_RS43045 ENOG41068WN HEP84_RS43085 ENOG4108UZX fmn reductase HEP84_RS43090 ENOG4105CAY ferredoxin--nadp reductase HEP84_RS43120 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP84_RS43125 ENOG4105CTU Proline racemase HEP84_RS43145 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP84_RS43150 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HEP84_RS43155 ENOG4105CG3 alpha amylase, catalytic region HEP84_RS43175 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP84_RS43180 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP84_RS43285 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HEP84_RS43290 ENOG4105CSH Transporter HEP84_RS43300 ENOG4105F2Z 3-oxoadipate enol-lactonase HEP84_RS43305 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HEP84_RS43320 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS43335 ENOG41067TZ transcriptional regulator, MarR family HEP84_RS43345 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HEP84_RS43405 ENOG4105D7V transposase HEP84_RS43410 ENOG4105EKQ RNA-directed DNA polymerase HEP84_RS43415 ENOG4105EKQ RNA-directed DNA polymerase HEP84_RS43430 ENOG4105DQE DNA ligase HEP84_RS43435 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS43450 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP84_RS43490 ENOG4106V2I dimethylaminohydrolase HEP84_RS43495 ENOG4105C5H ABC transporter HEP84_RS43510 ENOG4105KF0 sporulation and cell division protein, SsgA HEP84_RS43535 ENOG4105EG6 Saccharopine dehydrogenase HEP84_RS43540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP84_RS43545 ENOG4105DYW oxidoreductase HEP84_RS43550 ENOG4105C1G acyl-Coa dehydrogenase HEP84_RS43555 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS43560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP84_RS43605 ENOG4105C5H ABC transporter HEP84_RS43615 ENOG4105BZM domain protein HEP84_RS43635 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS43650 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HEP84_RS43680 ENOG4108MDK Dehydrogenase HEP84_RS43700 ENOG4105EY8 ABC transporter HEP84_RS43705 ENOG4105FBD synthase HEP84_RS43725 ENOG4105EWU Squalene--hopene cyclase HEP84_RS43740 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HEP84_RS43765 ENOG4105M2Z protein tyrosine serine phosphatase HEP84_RS43780 ENOG4108I0C methyltransferase HEP84_RS43825 ENOG4105C7K acetolactate synthase HEP84_RS43835 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS43845 ENOG4105BZU Histidine kinase HEP84_RS43900 ENOG4105CPQ Dehydrogenase HEP84_RS43905 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HEP84_RS43910 ENOG4106NZI LysR family Transcriptional regulator HEP84_RS43965 ENOG4105BZ1 (ABC) transporter HEP84_RS43995 ENOG4105C0F tryptophanase EC 4.1.99.1 HEP84_RS44015 ENOG4105XTG Pfam:DUF156 HEP84_RS44035 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HEP84_RS44060 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HEP84_RS44165 ENOG4107RQ0 Maleylacetate reductase HEP84_RS44170 ENOG4105ETS cytosine purines uracil thiamine allantoin HEP84_RS44175 ENOG4105DWF phosphomethylpyrimidine kinase HEP84_RS44180 ENOG4105ECR NmrA family HEP84_RS44255 ENOG41079R3 acyl carrier protein HEP84_RS44265 ENOG4105KTE polyketide synthesis cyclase HEP84_RS44280 ENOG4105E9K Isocitrate dehydrogenase HEP84_RS44290 ENOG4105D64 Mechanosensitive ion channel HEP84_RS44295 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS44310 ENOG4105EYF MMPL domain protein HEP84_RS44335 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HEP84_RS44345 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP84_RS44375 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HEP84_RS44395 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HEP84_RS44410 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HEP84_RS44435 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEP84_RS44440 ENOG4105C5I Dehydrogenase HEP84_RS44455 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP84_RS44460 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HEP84_RS44465 ENOG4105T38 integral membrane protein HEP84_RS44470 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HEP84_RS44480 ENOG4105D5U fad dependent oxidoreductase HEP84_RS44490 ENOG4108Z4U Ferredoxin HEP84_RS44495 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS44550 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HEP84_RS44565 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEP84_RS44585 ENOG4107QPH glycogen) synthase HEP84_RS44590 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HEP84_RS44610 ENOG4107S1E Beta-lactamase HEP84_RS44615 ENOG4108R85 Short chain dehydrogenase HEP84_RS44625 ENOG4108M4U conserved membrane protein HEP84_RS44660 ENOG41060NJ transcriptional regulator HEP84_RS44695 ENOG41073TP transcriptional regulator HEP84_RS44705 ENOG4105C2J ABC transporter HEP84_RS44710 ENOG4105CNN ABC, transporter HEP84_RS44715 ENOG4105DIA mandelate racemase muconate lactonizing HEP84_RS44720 ENOG4105CHR reductase HEP84_RS44785 ENOG4105CRK lysyL-tRNA synthetase HEP84_RS44790 ENOG4108ZJ4 polysaccharide deacetylase HEP84_RS44830 ENOG4105BZU Histidine kinase HEP84_RS44845 ENOG4108R85 Short chain dehydrogenase HEP84_RS44850 ENOG4105C5Q Transcriptional regulator HEP84_RS44865 ENOG4105E33 succinate dehydrogenase HEP84_RS44885 ENOG4105DEN Luciferase family HEP84_RS44900 ENOG4105CPC Aldo Keto reductase HEP84_RS44905 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HEP84_RS44960 ENOG4105DU6 RNA polymerase HEP84_RS45000 ENOG41067HS methyltransferase HEP84_RS45005 ENOG4108V75 Glutamine amidotransferase HEP84_RS45010 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HEP84_RS45015 ENOG4105D1K glutamate--cysteine ligase HEP84_RS45035 ENOG4105DZ6 Band 7 protein HEP84_RS45050 ENOG41060NJ transcriptional regulator HEP84_RS45065 ENOG41080RH Thioredoxin HEP84_RS45075 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP84_RS45120 ENOG4105EUB pirin domain protein HEP84_RS45140 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP84_RS45180 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP84_RS45190 ENOG4108XNA Gas vesicle HEP84_RS45195 ENOG4107ETC gas vesicle protein HEP84_RS45205 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) HEP84_RS45220 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HEP84_RS45265 ENOG4105VBF alkaline shock protein HEP84_RS45305 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP84_RS45325 ENOG4105F5R ABC transporter HEP84_RS45330 ENOG4105C2J ABC transporter HEP84_RS45335 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP84_RS45340 ENOG4105CK5 oxidoreductase HEP84_RS45360 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS45365 ENOG4105CWX Alpha-1,2-mannosidase HEP84_RS45380 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP84_RS45405 ENOG4105J0Q Transcriptional regulator HEP84_RS45415 ENOG4108JJB ABC transporter HEP84_RS45420 ENOG4108JJB ABC transporter HEP84_RS45455 ENOG410667J hydrolase HEP84_RS45530 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP84_RS45535 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HEP84_RS45540 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HEP84_RS45545 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HEP84_RS45550 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HEP84_RS45555 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP84_RS45565 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS45575 ENOG4108ZJI phenylacetic acid degradation protein HEP84_RS45585 ENOG4106T9R serine protease HEP84_RS45590 ENOG4107QTZ amino acid HEP84_RS45665 ENOG4105DSG hydrolase family 43 HEP84_RS45680 ENOG4105DPX Hydrogenase, large subunit HEP84_RS45710 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HEP84_RS45730 ENOG4105CQS hydrogenase expression formation protein HypD HEP84_RS45750 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HEP84_RS45765 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein HEP84_RS45800 ENOG4105E90 ABC transporter HEP84_RS45805 ENOG4105E90 ABC transporter HEP84_RS45815 ENOG4108TM9 integral membrane protein HEP84_RS45835 ENOG4108IJ8 ABC transporter HEP84_RS45840 ENOG41080R8 Conserved Protein HEP84_RS45845 ENOG4107QR9 Iron-sulfur cluster binding protein HEP84_RS45850 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HEP84_RS45855 ENOG4105DET Rhamnulokinase HEP84_RS45870 ENOG4105C2J ABC transporter HEP84_RS45885 ENOG4105F5R ABC transporter HEP84_RS45890 ENOG4105D4B ABC, transporter HEP84_RS45905 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS45915 ENOG4108KPJ rna polymerase sigma factor HEP84_RS45920 ENOG4105DDN Pentapeptide repeat-containing protein HEP84_RS45925 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HEP84_RS45930 ENOG4108R86 Transcriptional regulator HEP84_RS45940 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HEP84_RS45995 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HEP84_RS46040 ENOG4105DCG PHP domain protein HEP84_RS46080 ENOG4105NAE bifunctional deaminase-reductase domain protein HEP84_RS46115 ENOG4107TPY serine threonine protein kinase HEP84_RS46155 ENOG4105CPQ Dehydrogenase HEP84_RS46180 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEP84_RS46200 ENOG4105C26 Dehydrogenase HEP84_RS46215 ENOG4105ECQ AraC Family Transcriptional Regulator HEP84_RS46240 ENOG4107RCI amp-dependent synthetase and ligase HEP84_RS46265 ENOG4105CUB amino acid HEP84_RS46305 ENOG4106YKD Cytochrome p-450 HEP84_RS46345 ENOG4105EBM Alpha Beta Hydrolase Fold protein HEP84_RS46380 ENOG4105CNT hydrolase family 2 HEP84_RS46385 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP84_RS46420 ENOG4108JQ1 Dehydrogenase HEP84_RS46425 ENOG4105DMF Dehydrogenase HEP84_RS46450 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HEP84_RS46460 ENOG4106C4P Strong inhibitor of bacterial serine proteases such as subtilisin (By similarity) HEP84_RS46470 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HEP84_RS46495 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP84_RS46520 ENOG4108JJA ABC, transporter HEP84_RS46555 ENOG4105EXC Acyl-transferase HEP84_RS46570 ENOG4105XRQ Xanthine dehydrogenase accessory factor HEP84_RS46630 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP84_RS46645 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEP84_RS46715 ENOG4105CHR reductase HEP84_RS46745 ENOG4105E2R ROK family HEP84_RS46835 ENOG4105EQX glucarate dehydratase HEP84_RS46850 ENOG4107RSM transcriptional regulator HEP84_RS46865 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP84_RS46870 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP84_RS46880 ENOG4105WZ4 isomerase HEP84_RS46890 ENOG4105EBR Carboxylesterase HEP84_RS46930 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP84_RS46945 ENOG4105CHR reductase HEP84_RS46955 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HEP84_RS47000 ENOG4105CFG Acts as a chaperone (By similarity) HEP84_RS47005 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP84_RS47035 ENOG4108YZ9 Urea amidohydrolase subunit gamma HEP84_RS47050 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HEP84_RS47055 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HEP84_RS47105 ENOG4105VNT transposase (IS4 family) protein HEP84_RS47220 ENOG4105VNT transposase (IS4 family) protein HEP84_RS47245 ENOG4107TK4 histidinol-phosphate phosphatase HEP84_RS47255 ENOG4105C9B Cysteine desulfurase HEP84_RS47265 ENOG4105DDW LysR family Transcriptional regulator HEP84_RS47280 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS47290 ENOG4105EBR Carboxylesterase HEP84_RS47310 ENOG4105DQE DNA ligase HEP84_RS47345 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP84_RS47360 ENOG41068HZ 50S ribosomal protein L32 HEP84_RS47405 ENOG4105C5I Dehydrogenase HEP84_RS47415 ENOG4105E7W lamb ycsf family protein HEP84_RS47420 ENOG4105P4J Allophanate hydrolase, subunit 1 HEP84_RS47425 ENOG4107R7A Allophanate hydrolase subunit 2 HEP84_RS47430 ENOG4105CSH Transporter HEP84_RS47445 ENOG4105JSC dimethylmenaquinone methyltransferase HEP84_RS47455 ENOG4108PVQ transcriptional regulator HEP84_RS47485 ENOG4105F7P transcriptional regulator AsnC family HEP84_RS47525 ENOG4105C26 Dehydrogenase HEP84_RS47545 ENOG4107RSM transcriptional regulator HEP84_RS47560 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HEP84_RS47600 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HEP84_RS47700 ENOG4105VDT -acetyltransferase HEP84_RS47710 ENOG4105VEQ Cold shock protein HEP84_RS47740 ENOG4105DEG Vwa containing coxe family protein HEP84_RS47745 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP84_RS47760 ENOG4108JPW Aminotransferase HEP84_RS47765 ENOG4107B7Y DNA-binding transcriptional regulator FruR HEP84_RS47790 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEP84_RS47805 ENOG41066F8 ROK family HEP84_RS47815 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP84_RS47820 ENOG4105DRS transport system, permease HEP84_RS47855 ENOG4105VNT transposase (IS4 family) protein HEP84_RS47895 ENOG4105K4I Scp-like extracellular HEP84_RS47940 ENOG4105EGE secreted protein HEP84_RS47945 ENOG4106UDK Cellulose-binding, family II HEP84_RS47965 ENOG4107SET aldo keto reductase HEP84_RS47970 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP84_RS47975 ENOG4105CWX Alpha-1,2-mannosidase HEP84_RS47995 ENOG4105CI2 imidazolone-5-propionate hydrolase HEP84_RS48000 ENOG4107TPY serine threonine protein kinase HEP84_RS48035 ENOG41082J7 Rhodanese domain protein HEP84_RS48045 ENOG4105VPX protein, conserved in bacteria HEP84_RS48080 ENOG4105D29 Helix-turn-helix type 11 domain protein HEP84_RS48085 ENOG4105HHS UPF0256 protein HEP84_RS48115 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HEP84_RS48130 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS48140 ENOG4105EX0 alpha-galactosidase HEP84_RS48150 ENOG4107S5I aldo keto reductase HEP84_RS48155 ENOG4105CHJ isochorismatase hydrolase HEP84_RS48175 ENOG4105CUX Signal transduction histidine kinase HEP84_RS48180 ENOG4105C3M thioredoxin reductase HEP84_RS48210 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEP84_RS48220 ENOG4105F27 Major Facilitator HEP84_RS48225 ENOG41082YX Transcriptional regulator, arsr family HEP84_RS48245 ENOG4105IDI abc transporter atp-binding protein HEP84_RS48280 ENOG4105E4C Lytic transglycosylase catalytic HEP84_RS48300 ENOG4105DND Transcriptional regulator HEP84_RS48305 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEP84_RS48330 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS48340 ENOG4105C4C beta-galactosidase HEP84_RS48360 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS48365 ENOG4105D3W isochorismatase HEP84_RS48395 ENOG4105EMN RNA polymerase sigma factor HEP84_RS48430 ENOG4105BZU Histidine kinase HEP84_RS48450 ENOG4108U3T pfkb domain protein HEP84_RS48525 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP84_RS48555 ENOG4108KPJ rna polymerase sigma factor HEP84_RS48595 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS48620 ENOG4105BZU Histidine kinase HEP84_RS48630 ENOG4105CJW magnesium transporter HEP84_RS48670 ENOG4105CSR polyphosphate kinase 2 HEP84_RS48675 ENOG4107QRI Phosphoketolase HEP84_RS48680 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEP84_RS48705 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEP84_RS48725 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEP84_RS48740 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEP84_RS48775 ENOG41068KF Universal stress protein HEP84_RS48790 ENOG4105E2A Dehydrogenase HEP84_RS48805 ENOG4105D5Q Arginine ornithine antiporter HEP84_RS48810 ENOG4105CEU Arginine dihydrolase HEP84_RS48815 ENOG4105DBV ornithine carbamoyltransferase HEP84_RS48830 ENOG4105F1A Pyruvate formate-lyase HEP84_RS48850 ENOG4105D7V transposase HEP84_RS48870 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS48885 ENOG4105VEQ Cold shock protein HEP84_RS48890 ENOG4105C1J atp-dependent rna helicase HEP84_RS48940 ENOG4108JJA ABC, transporter HEP84_RS48980 ENOG4105D7V transposase HEP84_RS48990 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HEP84_RS49035 ENOG4105CIG ABC transporter HEP84_RS49070 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HEP84_RS49095 ENOG4108Z6Z Transcriptional regulator HEP84_RS49150 ENOG4108PBA serine threonine protein kinase HEP84_RS49155 ENOG4105BZ1 (ABC) transporter HEP84_RS49195 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP84_RS49200 ENOG4108Z6Z Transcriptional regulator HEP84_RS49210 ENOG4107HP6 Transcriptional regulator HEP84_RS49220 ENOG4105CYP glycoside hydrolase, family HEP84_RS49225 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEP84_RS49230 ENOG4105HSS phospholipase C HEP84_RS49270 ENOG4105CHJ isochorismatase hydrolase HEP84_RS49315 ENOG4105CHR reductase HEP84_RS49320 ENOG4105SKE transcriptional Regulator LysR family HEP84_RS49355 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEP84_RS49365 ENOG4105EZR dyp-type peroxidase family protein HEP84_RS49390 ENOG4105CF7 AraC family transcriptional regulator HEP84_RS49425 ENOG4105MHT Transcriptional regulator, ARSR family HEP84_RS49440 ENOG4108MP6 LysR family Transcriptional regulator HEP84_RS49525 ENOG4105CNN ABC, transporter HEP84_RS49530 ENOG4105C2J ABC transporter HEP84_RS49535 ENOG4108MJI response regulator HEP84_RS49555 ENOG4105CJ3 phosphate transporter HEP84_RS49575 ENOG4107RN3 metallophosphoesterase HEP84_RS49670 ENOG4108YIQ Alpha beta hydrolase HEP84_RS49690 ENOG4105BZ1 (ABC) transporter HEP84_RS49700 ENOG4105C4M (Ubiquinol oxidase) subunit I HEP84_RS49710 ENOG4108UZX fmn reductase HEP84_RS49715 ENOG4105KF0 sporulation and cell division protein, SsgA HEP84_RS49730 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP84_RS49775 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP84_RS49795 ENOG4107SFI Major Facilitator superfamily HEP84_RS49800 ENOG4105XPP Protein of unknown function (DUF1275) HEP84_RS49805 ENOG4108VGI doxx family HEP84_RS49810 ENOG4105CHJ isochorismatase hydrolase HEP84_RS49835 ENOG4107QN2 dihydrolipoyl dehydrogenase HEP84_RS49895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP84_RS49930 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HEP84_RS49940 ENOG4105C0B DNA polymerase III (alpha subunit) HEP84_RS49950 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS49965 ENOG4108IG5 Transcriptional regulator HEP84_RS50030 ENOG4105D5G Transposase HEP84_RS50080 ENOG4105CHR reductase HEP84_RS50085 ENOG4105CHR reductase HEP84_RS50115 ENOG4105DNH Major Facilitator HEP84_RS50125 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS50155 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP84_RS50175 ENOG4108IND Tetr family transcriptional regulator HEP84_RS50190 ENOG4105CHR reductase HEP84_RS50255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP84_RS50265 ENOG4105DVC DnaJ domain protein HEP84_RS50270 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP84_RS50330 ENOG4108HKT sucrose-6-phosphate hydrolase HEP84_RS50340 ENOG4105C3U ABC transporter HEP84_RS50350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP84_RS50355 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HEP84_RS50360 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS50365 ENOG4105CPC Aldo Keto reductase HEP84_RS50485 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HEP84_RS50500 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEP84_RS50510 ENOG4108HKT sucrose-6-phosphate hydrolase HEP84_RS50530 ENOG4105DRS transport system, permease HEP84_RS50545 ENOG4105D74 hydrolase HEP84_RS50560 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS50575 ENOG4105ECB domain protein HEP84_RS50580 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEP84_RS50605 ENOG4108I9W Membrane HEP84_RS50615 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP84_RS50635 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS50670 ENOG4105EBM Alpha Beta Hydrolase Fold protein HEP84_RS50705 ENOG4105EMU Dehydrogenase HEP84_RS50730 ENOG4105D7V transposase HEP84_RS50830 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HEP84_RS50835 ENOG4105KDC 50s ribosomal protein l28 HEP84_RS50845 ENOG4105NRA 50s ribosomal protein l31 type b HEP84_RS50855 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEP84_RS50865 ENOG4108PJD permease HEP84_RS50925 ENOG4105G9B Transcriptional regulator HEP84_RS50930 ENOG4105E6M Sulphatase-modifying factor protein HEP84_RS50935 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HEP84_RS50960 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS50980 ENOG4107UNS conserved inner membrane protein HEP84_RS50985 ENOG4105CVK Glutamate decarboxylase HEP84_RS51010 ENOG4105C57 major facilitator superfamily HEP84_RS51030 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS51035 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP84_RS51065 ENOG4107QN2 dihydrolipoyl dehydrogenase HEP84_RS51085 ENOG4105CHR reductase HEP84_RS51090 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP84_RS51140 ENOG4105F7P transcriptional regulator AsnC family HEP84_RS51185 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP84_RS51205 ENOG4105EUB pirin domain protein HEP84_RS51210 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS51220 ENOG4105EMU Dehydrogenase HEP84_RS51245 ENOG4105EMN RNA polymerase sigma factor HEP84_RS51280 ENOG4105D74 hydrolase HEP84_RS51315 ENOG4105E5D amino acid HEP84_RS51320 ENOG4105EMU Dehydrogenase HEP84_RS51325 ENOG4105CHP RNA polymerase HEP84_RS51330 ENOG4105GRZ Ycii-related protein HEP84_RS51380 ENOG4105E2B Taurine dioxygenase HEP84_RS51385 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP84_RS51390 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HEP84_RS51405 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS51420 ENOG4106A3M Cytochrome p-450 HEP84_RS51430 ENOG4105BZU Histidine kinase HEP84_RS51435 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS51490 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS51495 ENOG4105BZU Histidine kinase HEP84_RS51530 ENOG4105CQB FAD linked oxidase domain protein HEP84_RS51535 ENOG4105E39 Enoyl-CoA hydratase HEP84_RS51585 ENOG4108JNI Alpha beta hydrolase HEP84_RS51595 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEP84_RS51615 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP84_RS51620 ENOG4108Z6Z Transcriptional regulator HEP84_RS51655 ENOG4105WH1 Two component transcriptional regulator luxr family HEP84_RS51670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP84_RS51675 ENOG4105C26 Dehydrogenase HEP84_RS51680 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEP84_RS51695 ENOG4105DEN Luciferase family HEP84_RS51700 ENOG4108IG5 Transcriptional regulator HEP84_RS51730 ENOG4105V9V Short-chain dehydrogenase reductase Sdr HEP84_RS51750 ENOG4105ETX regulatoR HEP84_RS51825 ENOG4108JGH Tetr family transcriptional regulator HEP84_RS51865 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP84_RS51875 ENOG4108R96 Methyltransferase, YaeB family HEP84_RS51915 ENOG4108KPJ rna polymerase sigma factor HEP84_RS51950 ENOG4105KVH Transcriptional regulator HEP84_RS52030 ENOG4105ECQ AraC Family Transcriptional Regulator HEP84_RS52035 ENOG4105EYF MMPL domain protein HEP84_RS52045 ENOG4105H3G oxidoreductase HEP84_RS52055 ENOG4105C26 Dehydrogenase HEP84_RS52060 ENOG4108ZX5 transcriptional regulator HEP84_RS52095 ENOG4108W6C Dehydrogenase HEP84_RS52105 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP84_RS52110 ENOG4105CPC Aldo Keto reductase HEP84_RS52120 ENOG4105BZU Histidine kinase HEP84_RS52125 ENOG4108S01 response regulator HEP84_RS52215 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HEP84_RS52240 ENOG4105CHH sulfate transporter HEP84_RS52250 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HEP84_RS52285 ENOG41085W3 Transposase HEP84_RS52320 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP84_RS52395 ENOG4107QTZ amino acid HEP84_RS52415 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HEP84_RS52440 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HEP84_RS52445 ENOG4105DQE DNA ligase HEP84_RS52550 ENOG4107SVN transposase HEP84_RS52585 ENOG4105NAF rna polymerase sigma factor HEP84_RS52610 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS52665 ENOG4105CPC Aldo Keto reductase HEP84_RS52670 ENOG41067SE Tetr family transcriptional regulator HEP84_RS52865 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP84_RS52870 ENOG4105CHR reductase HEP84_RS52875 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HEP84_RS52880 ENOG4105D7V transposase HEP84_RS52890 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HEP84_RS52915 ENOG4105CPC Aldo Keto reductase HEP84_RS52925 ENOG4105D7V transposase HEP84_RS52960 ENOG4105D7V transposase HEP84_RS52970 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEP84_RS53005 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HEP84_RS53060 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEP84_RS53070 ENOG4105CEY Amp-dependent synthetase and ligase HEP84_RS53085 ENOG4105ECR NmrA family HEP84_RS53095 ENOG4105EZE Cupin 4 family protein HEP84_RS53115 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HEP84_RS53140 ENOG4105C9B Cysteine desulfurase HEP84_RS53200 ENOG4105BZP glycoside hydrolase 15-related HEP84_RS53240 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP84_RS53245 ENOG4108KPJ rna polymerase sigma factor HEP84_RS53320 ENOG4105FP9 thiamine pyrophosphate HEP84_RS53325 ENOG4105CHR reductase HEP84_RS53465 ENOG4108BUD transposase HEP84_RS53495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP84_RS53530 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HEP84_RS53540 ENOG41082BM Transcriptional regulator, arsr family HEP84_RS53585 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HEP84_RS53680 ENOG4105DBI uridine monophosphokinase HEP84_RS53690 ENOG4105EMU Dehydrogenase HEP84_RS53705 ENOG4105E1F short-chain dehydrogenase reductase HEP84_RS53740 ENOG4105EKQ RNA-directed DNA polymerase HEP84_RS53760 ENOG4105EKQ RNA-directed DNA polymerase HEP84_RS53815 ENOG4108KC1 acyl-Coa dehydrogenase HEP84_RS53820 ENOG4107RQ0 Maleylacetate reductase HEP84_RS53845 ENOG4107RSM transcriptional regulator HEP84_RS53850 ENOG4105CHU acetyl-coa acetyltransferase HEP84_RS53860 ENOG4107QNJ CoA-transferase subunit B HEP84_RS53885 ENOG4105H1N peptidase, M24 HEP84_RS53890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP84_RS53895 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS53910 ENOG4108JYK Dehydrogenase HEP84_RS53925 ENOG4105ETE Transcriptional regulator (LacI family HEP84_RS53945 ENOG4105C0Z ABC transporter HEP84_RS53950 ENOG4105CJ1 ABC, transporter HEP84_RS53960 ENOG4105C32 Amino acid ABC transporter (Permease) HEP84_RS53975 ENOG4105CHJ isochorismatase hydrolase HEP84_RS53980 ENOG4105XPP Protein of unknown function (DUF1275) HEP84_RS53985 ENOG4105D7V transposase HEP84_RS54020 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HEP84_RS54030 ENOG4105D7T ABC transporter HEP84_RS54040 ENOG4108YYC ycei family HEP84_RS54045 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HEP84_RS54070 ENOG4108BUD transposase HEP84_RS54085 ENOG4105KF0 sporulation and cell division protein, SsgA HEP84_RS54115 ENOG4108BUD transposase HEP84_RS54145 ENOG4108HMN Caspase domain HEP84_RS54275 ENOG4107SVN transposase HEP84_RS54370 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) HEP84_RS54375 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HEP84_RS54380 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HEP84_RS54385 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HEP84_RS54450 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP84_RS54495 ENOG4105DQ6 Transposase HEP84_RS54500 ENOG4105F9F transposase HEP84_RS54530 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HEP84_RS54550 ENOG4105CFQ glutamine synthetase HEP84_RS54560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEP84_RS54600 ENOG4105D5G Transposase HEP84_RS54675 ENOG4108EHY type IV secretion system HEP84_RS54795 ENOG4105D9P serine threonine protein kinase HEP84_RS54800 ENOG4107TPY serine threonine protein kinase HEP84_RS54850 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP84_RS54855 ENOG4107S1E Beta-lactamase HEP84_RS54875 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP84_RS54895 ENOG4105CMR udp-glucose 4-epimerase HEP84_RS54910 ENOG41067SE Tetr family transcriptional regulator