locus-tag	class	description
HEP84_RS00045	COG0572	uridine kinase
HEP84_RS00050	COG0572	uridine kinase
HEP84_RS00110	COG4941	Belongs to the sigma-70 factor family
HEP84_RS00140	COG4977	sequence-specific DNA binding
HEP84_RS00220	COG1278	Cold shock
HEP84_RS00240	COG2319	Wd-40 repeat
HEP84_RS00240	COG4249	Peptidase C14 caspase catalytic subunit p20
HEP84_RS00355	COG3385	transposase activity
HEP84_RS00370	COG2318	DinB family
HEP84_RS00435	COG2197	response regulator
HEP84_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS00525	COG2084	Dehydrogenase
HEP84_RS00540	COG2267	carboxylic ester hydrolase activity
HEP84_RS00545	COG0114	fumarate hydratase activity
HEP84_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS00570	COG3385	transposase activity
HEP84_RS00595	COG4221	oxidoreductase activity
HEP84_RS00615	COG0567	Dehydrogenase, E1 component
HEP84_RS00615	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP84_RS00615	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP84_RS00615	COG0567	Dehydrogenase, E1 component
HEP84_RS00660	COG1090	epimerase
HEP84_RS00665	COG1595	DNA-templated transcription, initiation
HEP84_RS00695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS00705	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS00785	COG1660	Displays ATPase and GTPase activities
HEP84_RS00815	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEP84_RS00850	COG0596	Alpha beta hydrolase
HEP84_RS00855	COG0406	alpha-ribazole phosphatase activity
HEP84_RS00860	COG1309	transcriptional regulator
HEP84_RS00865	COG1902	pentaerythritol trinitrate reductase activity
HEP84_RS00865	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP84_RS00885	COG3344	reverse transcriptase
HEP84_RS00980	COG0069	glutamate synthase activity
HEP84_RS00990	COG0596	Alpha beta hydrolase
HEP84_RS01000	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP84_RS01015	COG1131	(ABC) transporter
HEP84_RS01020	COG4585	Histidine kinase
HEP84_RS01025	COG2197	response regulator
HEP84_RS01060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP84_RS01070	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HEP84_RS01145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP84_RS01185	COG0154	amidase activity
HEP84_RS01205	COG0402	S-adenosylhomocysteine deaminase activity
HEP84_RS01255	COG0384	phenazine biosynthesis protein PhzF
HEP84_RS01305	COG3876	Protein conserved in bacteria
HEP84_RS01320	COG1175	transmembrane transport
HEP84_RS01335	COG0300	oxidoreductase activity
HEP84_RS01345	COG4977	sequence-specific DNA binding
HEP84_RS01360	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEP84_RS01375	COG1309	transcriptional regulator
HEP84_RS01380	COG1902	pentaerythritol trinitrate reductase activity
HEP84_RS01390	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS01405	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS01410	COG1309	transcriptional regulator
HEP84_RS01415	COG0667	Aldo Keto reductase
HEP84_RS01420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HEP84_RS01455	COG4948	Mandelate Racemase Muconate Lactonizing
HEP84_RS01475	COG0395	ABC-type sugar transport system, permease component
HEP84_RS01480	COG1175	transmembrane transport
HEP84_RS01495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP84_RS01510	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS01580	COG0366	Alpha amylase catalytic
HEP84_RS01605	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS01635	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS01650	COG0789	Transcriptional regulator
HEP84_RS01665	COG2376	Dihydroxyacetone kinase
HEP84_RS01675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP84_RS01700	COG1376	ErfK ybiS ycfS ynhG family protein
HEP84_RS01715	COG0667	Aldo Keto reductase
HEP84_RS01730	COG1233	COG1233 Phytoene dehydrogenase and related
HEP84_RS01755	COG1609	Transcriptional regulator
HEP84_RS01775	COG0395	ABC-type sugar transport system, permease component
HEP84_RS01870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP84_RS01890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP84_RS01895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP84_RS01975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP84_RS01980	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEP84_RS02005	COG0589	response to stress
HEP84_RS02025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP84_RS02030	COG0330	HflC and HflK could
HEP84_RS02045	COG0259	pyridoxamine-phosphate oxidase activity
HEP84_RS02055	COG2226	methyltransferase
HEP84_RS02060	COG0505	Belongs to the CarA family
HEP84_RS02090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HEP84_RS02100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP84_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS02125	COG2188	Transcriptional regulator
HEP84_RS02135	COG1175	transmembrane transport
HEP84_RS02140	COG0395	ABC-type sugar transport system, permease component
HEP84_RS02245	COG1609	Transcriptional regulator
HEP84_RS02255	COG2814	Major facilitator Superfamily
HEP84_RS02260	COG0673	inositol 2-dehydrogenase activity
HEP84_RS02265	COG1082	Xylose isomerase domain protein TIM barrel
HEP84_RS02275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP84_RS02285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP84_RS02315	COG3469	chitinase activity
HEP84_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS02390	COG1764	response to oxidative stress
HEP84_RS02470	COG0604	alcohol dehydrogenase
HEP84_RS02470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS02470	COG3321	synthase
HEP84_RS02470	COG4221	oxidoreductase activity
HEP84_RS02505	COG3250	beta-galactosidase activity
HEP84_RS02570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP84_RS02600	COG2197	response regulator
HEP84_RS02605	COG1609	Transcriptional regulator
HEP84_RS02630	COG1082	Xylose isomerase domain protein TIM barrel
HEP84_RS02645	COG3718	enzyme involved in inositol metabolism
HEP84_RS02650	COG3962	Belongs to the TPP enzyme family
HEP84_RS02665	COG1082	Xylose isomerase domain protein TIM barrel
HEP84_RS02695	COG2226	methyltransferase
HEP84_RS02700	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP84_RS02735	COG4213	ABC transporter substrate-binding protein
HEP84_RS02745	COG4213	ABC transporter substrate-binding protein
HEP84_RS02755	COG4214	carbohydrate transport
HEP84_RS02765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP84_RS02770	COG1414	Transcriptional regulator
HEP84_RS02790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS02800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP84_RS02805	COG0640	Transcriptional regulator
HEP84_RS02810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP84_RS02815	COG0248	Ppx GppA phosphatase
HEP84_RS02850	COG0395	ABC-type sugar transport system, permease component
HEP84_RS02880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP84_RS02885	COG1120	ATPase activity
HEP84_RS02935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP84_RS02940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP84_RS02990	COG1191	sigma factor activity
HEP84_RS02995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP84_RS03035	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP84_RS03035	COG1672	PFAM Archaeal ATPase
HEP84_RS03080	COG1609	Transcriptional regulator
HEP84_RS03085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP84_RS03090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP84_RS03090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP84_RS03090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP84_RS03090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP84_RS03095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HEP84_RS03105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEP84_RS03115	COG1064	alcohol dehydrogenase
HEP84_RS03145	COG0009	L-threonylcarbamoyladenylate synthase
HEP84_RS03155	COG0443	Heat shock 70 kDa protein
HEP84_RS03160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP84_RS03175	COG0542	response to heat
HEP84_RS03190	COG1414	Transcriptional regulator
HEP84_RS03195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP84_RS03200	COG2610	gluconate transmembrane transporter activity
HEP84_RS03205	COG4948	Mandelate Racemase Muconate Lactonizing
HEP84_RS03220	COG1136	(ABC) transporter
HEP84_RS03225	COG4585	Histidine kinase
HEP84_RS03230	COG2197	response regulator
HEP84_RS03235	COG1309	transcriptional regulator
HEP84_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS03250	COG1595	DNA-templated transcription, initiation
HEP84_RS03260	COG2362	D-Aminopeptidase
HEP84_RS03285	COG2814	Major facilitator Superfamily
HEP84_RS03300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP84_RS03305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP84_RS03310	COG2186	Transcriptional regulator
HEP84_RS03330	COG5006	permease, DMT superfamily
HEP84_RS03345	COG0477	Major facilitator Superfamily
HEP84_RS03435	COG0464	growth
HEP84_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS03585	COG0604	alcohol dehydrogenase
HEP84_RS03585	COG3321	synthase
HEP84_RS03590	COG1489	DNA binding
HEP84_RS03630	COG1082	Xylose isomerase domain protein TIM barrel
HEP84_RS03670	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HEP84_RS03690	COG0675	Transposase, IS605 OrfB family
HEP84_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS03820	COG1309	transcriptional regulator
HEP84_RS03855	COG1881	PFAM PEBP family protein
HEP84_RS03870	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS03875	COG2186	Transcriptional regulator
HEP84_RS03880	COG1024	Enoyl-CoA hydratase
HEP84_RS03890	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS03905	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS03915	COG1024	Enoyl-CoA hydratase
HEP84_RS03920	COG0183	Belongs to the thiolase family
HEP84_RS03925	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS03945	COG1024	Enoyl-CoA hydratase
HEP84_RS03950	COG1024	Enoyl-CoA hydratase
HEP84_RS03990	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS03995	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS04010	COG2272	Belongs to the type-B carboxylesterase lipase family
HEP84_RS04015	COG1024	Enoyl-CoA hydratase
HEP84_RS04030	COG0183	Belongs to the thiolase family
HEP84_RS04035	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS04055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS04060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS04065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS04065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS04070	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS04090	COG1024	Enoyl-CoA hydratase
HEP84_RS04100	COG1309	transcriptional regulator
HEP84_RS04140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP84_RS04145	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS04160	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS04170	COG4638	Rieske (2fe-2S)
HEP84_RS04190	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS04200	COG3321	synthase
HEP84_RS04200	COG0604	alcohol dehydrogenase
HEP84_RS04210	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS04250	COG0745	RESPONSE REGULATOR receiver
HEP84_RS04260	COG1309	transcriptional regulator
HEP84_RS04265	COG4585	Histidine kinase
HEP84_RS04270	COG2197	response regulator
HEP84_RS04280	COG2814	Major facilitator Superfamily
HEP84_RS04360	COG0366	Alpha amylase catalytic
HEP84_RS04370	COG3281	Trehalose synthase
HEP84_RS04375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP84_RS04385	COG0842	Transport permease protein
HEP84_RS04405	COG0477	Major facilitator Superfamily
HEP84_RS04430	COG0494	nUDIX hydrolase
HEP84_RS04440	COG1609	Transcriptional regulator
HEP84_RS04470	COG3345	alpha-galactosidase
HEP84_RS04475	COG0395	ABC-type sugar transport system, permease component
HEP84_RS04480	COG1175	transmembrane transport
HEP84_RS04490	COG1940	carbohydrate kinase activity
HEP84_RS04490	COG1846	Transcriptional regulator
HEP84_RS04545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS04655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP84_RS04665	COG1132	(ABC) transporter
HEP84_RS04685	COG0577	efflux transmembrane transporter activity
HEP84_RS04685	COG1136	(ABC) transporter
HEP84_RS04690	COG4585	Histidine kinase
HEP84_RS04695	COG2197	response regulator
HEP84_RS04720	COG3424	synthase
HEP84_RS04725	COG1024	Enoyl-CoA hydratase
HEP84_RS04730	COG1024	Enoyl-CoA hydratase
HEP84_RS04745	COG2197	response regulator
HEP84_RS04760	COG4585	Histidine kinase
HEP84_RS04770	COG1349	DNA-binding transcription factor activity
HEP84_RS04775	COG2223	nitrite transmembrane transporter activity
HEP84_RS04805	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS04805	COG1454	alcohol dehydrogenase
HEP84_RS04810	COG1017	nitric oxide dioxygenase activity
HEP84_RS04810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP84_RS04820	COG4716	Myosin-crossreactive antigen
HEP84_RS04840	COG0517	IMP dehydrogenase activity
HEP84_RS04840	COG0516	GMP reductase activity
HEP84_RS04895	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HEP84_RS05005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP84_RS05030	COG3344	reverse transcriptase
HEP84_RS05080	COG1073	alpha beta
HEP84_RS05105	COG0395	ABC-type sugar transport system, permease component
HEP84_RS05110	COG1063	alcohol dehydrogenase
HEP84_RS05120	COG3344	reverse transcriptase
HEP84_RS05145	COG0431	NADPH-dependent FMN reductase
HEP84_RS05200	COG0675	Transposase, IS605 OrfB family
HEP84_RS05335	COG0745	RESPONSE REGULATOR receiver
HEP84_RS05395	COG4977	sequence-specific DNA binding
HEP84_RS05465	COG4221	oxidoreductase activity
HEP84_RS05470	COG0583	DNA-binding transcription factor activity
HEP84_RS05525	COG1473	amidohydrolase
HEP84_RS05530	COG2860	membrane
HEP84_RS05560	COG2409	Drug exporters of the RND superfamily
HEP84_RS05570	COG4221	oxidoreductase activity
HEP84_RS05575	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS05625	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP84_RS05650	COG1335	isochorismatase
HEP84_RS05695	COG0582	viral genome integration into host DNA
HEP84_RS05760	COG5285	phytanoyl-CoA dioxygenase
HEP84_RS05775	COG0667	Aldo Keto reductase
HEP84_RS05780	COG0789	Transcriptional regulator
HEP84_RS05815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HEP84_RS05820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP84_RS05850	COG3415	Transposase
HEP84_RS05895	COG1595	DNA-templated transcription, initiation
HEP84_RS05900	COG0477	Major facilitator Superfamily
HEP84_RS05925	COG3547	Transposase (IS116 IS110 IS902 family)
HEP84_RS05975	COG2353	YceI-like domain
HEP84_RS06025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP84_RS06110	COG0604	alcohol dehydrogenase
HEP84_RS06195	COG0596	Alpha beta hydrolase
HEP84_RS06200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP84_RS06200	COG1017	nitric oxide dioxygenase activity
HEP84_RS06285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP84_RS06355	COG4585	Histidine kinase
HEP84_RS06360	COG2197	response regulator
HEP84_RS06365	COG3328	transposase activity
HEP84_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS06545	COG2226	methyltransferase
HEP84_RS06575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS06590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS06590	COG0604	alcohol dehydrogenase
HEP84_RS06590	COG3321	synthase
HEP84_RS06590	COG4221	oxidoreductase activity
HEP84_RS06620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP84_RS06625	COG2315	Protein conserved in bacteria
HEP84_RS06690	COG0483	inositol monophosphate 1-phosphatase activity
HEP84_RS06695	COG0583	DNA-binding transcription factor activity
HEP84_RS06765	COG1733	regulation of RNA biosynthetic process
HEP84_RS06785	COG3537	Alpha-1,2-mannosidase
HEP84_RS06795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS06815	COG0596	Alpha beta hydrolase
HEP84_RS06820	COG0740	serine-type endopeptidase activity
HEP84_RS06825	COG0740	serine-type endopeptidase activity
HEP84_RS06835	COG2318	DinB family
HEP84_RS06850	COG0784	Response regulator, receiver
HEP84_RS06855	COG4251	negative regulation of phosphorylation
HEP84_RS06920	COG0842	Transport permease protein
HEP84_RS06920	COG1716	ATPase activity
HEP84_RS06920	COG1131	(ABC) transporter
HEP84_RS06940	COG2207	Transcriptional regulator
HEP84_RS06950	COG0667	Aldo Keto reductase
HEP84_RS06955	COG0583	DNA-binding transcription factor activity
HEP84_RS06970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP84_RS06975	COG0346	lactoylglutathione lyase activity
HEP84_RS06985	COG0671	phosphoesterase, PA-phosphatase related
HEP84_RS06995	COG0412	Dienelactone hydrolase
HEP84_RS07000	COG0667	Aldo Keto reductase
HEP84_RS07010	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS07050	COG4941	Belongs to the sigma-70 factor family
HEP84_RS07065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS07075	COG0431	NADPH-dependent FMN reductase
HEP84_RS07100	COG0702	epimerase
HEP84_RS07200	COG0531	amino acid
HEP84_RS07205	COG1940	carbohydrate kinase activity
HEP84_RS07210	COG3250	beta-galactosidase activity
HEP84_RS07230	COG3345	alpha-galactosidase
HEP84_RS07235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP84_RS07255	COG0667	Aldo Keto reductase
HEP84_RS07285	COG0367	asparagine synthase
HEP84_RS07290	COG0069	glutamate synthase activity
HEP84_RS07295	COG2235	arginine
HEP84_RS07310	COG0673	inositol 2-dehydrogenase activity
HEP84_RS07315	COG3511	phospholipase C
HEP84_RS07350	COG1404	Belongs to the peptidase S8 family
HEP84_RS07365	COG1672	PFAM Archaeal ATPase
HEP84_RS07365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP84_RS07405	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS07410	COG2366	antibiotic biosynthetic process
HEP84_RS07425	COG2070	2-Nitropropane dioxygenase
HEP84_RS07435	COG0515	serine threonine protein kinase
HEP84_RS07460	COG0006	proline dipeptidase activity
HEP84_RS07465	COG4934	collagen metabolic process
HEP84_RS07470	COG1309	transcriptional regulator
HEP84_RS07495	COG2130	NADP-dependent
HEP84_RS07500	COG0583	DNA-binding transcription factor activity
HEP84_RS07525	COG1733	regulation of RNA biosynthetic process
HEP84_RS07555	COG1335	isochorismatase
HEP84_RS07575	COG0277	FAD linked oxidase domain protein
HEP84_RS07585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS07595	COG0402	S-adenosylhomocysteine deaminase activity
HEP84_RS07600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP84_RS07605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP84_RS07635	COG1653	transport
HEP84_RS07640	COG1175	transmembrane transport
HEP84_RS07645	COG0395	ABC-type sugar transport system, permease component
HEP84_RS07650	COG1609	Transcriptional regulator
HEP84_RS07665	COG0402	S-adenosylhomocysteine deaminase activity
HEP84_RS07670	COG2233	PERMEase
HEP84_RS07710	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP84_RS07725	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP84_RS07765	COG0702	epimerase
HEP84_RS07770	COG1063	alcohol dehydrogenase
HEP84_RS07780	COG2226	methyltransferase
HEP84_RS07790	COG1309	transcriptional regulator
HEP84_RS07805	COG2197	response regulator
HEP84_RS07820	COG4221	oxidoreductase activity
HEP84_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS07895	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS07930	COG1609	Transcriptional regulator
HEP84_RS07950	COG2188	Transcriptional regulator
HEP84_RS07960	COG3962	Belongs to the TPP enzyme family
HEP84_RS07965	COG3718	enzyme involved in inositol metabolism
HEP84_RS07975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS08015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP84_RS08020	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS08030	COG1063	alcohol dehydrogenase
HEP84_RS08040	COG1335	isochorismatase
HEP84_RS08055	COG2072	flavoprotein involved in K transport
HEP84_RS08070	COG3547	Transposase (IS116 IS110 IS902 family)
HEP84_RS08085	COG1802	Transcriptional regulator
HEP84_RS08100	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP84_RS08105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP84_RS08110	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEP84_RS08120	COG0531	amino acid
HEP84_RS08160	COG0583	DNA-binding transcription factor activity
HEP84_RS08200	COG0726	polysaccharide deacetylase
HEP84_RS08245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEP84_RS08260	COG0587	DNA-directed DNA polymerase activity
HEP84_RS08290	COG2208	phosphoserine phosphatase activity
HEP84_RS08290	COG2770	Histidine kinase
HEP84_RS08330	COG0604	alcohol dehydrogenase
HEP84_RS08400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP84_RS08415	COG3290	protein histidine kinase activity
HEP84_RS08475	COG3467	pyridoxamine 5'-phosphate
HEP84_RS08495	COG0640	Transcriptional regulator
HEP84_RS08525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP84_RS08545	COG2267	carboxylic ester hydrolase activity
HEP84_RS08565	COG4221	oxidoreductase activity
HEP84_RS08570	COG1335	isochorismatase
HEP84_RS08610	COG2376	Dihydroxyacetone kinase
HEP84_RS08615	COG1461	Dihydroxyacetone kinase
HEP84_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS08640	COG5297	Belongs to the glycosyl hydrolase family 6
HEP84_RS08640	COG4733	cellulase activity
HEP84_RS08660	COG1902	pentaerythritol trinitrate reductase activity
HEP84_RS08660	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP84_RS08665	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP84_RS08685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP84_RS08710	COG3458	cephalosporin-C deacetylase activity
HEP84_RS08725	COG2188	Transcriptional regulator
HEP84_RS08735	COG2226	methyltransferase
HEP84_RS08740	COG0366	Alpha amylase catalytic
HEP84_RS08745	COG2267	carboxylic ester hydrolase activity
HEP84_RS08755	COG0300	oxidoreductase activity
HEP84_RS08800	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP84_RS08825	COG3795	YCII-related domain
HEP84_RS08835	COG0346	lactoylglutathione lyase activity
HEP84_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS08855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEP84_RS08870	COG2066	Belongs to the glutaminase family
HEP84_RS08885	COG1113	amino acid transport
HEP84_RS08895	COG1968	undecaprenyl-diphosphatase activity
HEP84_RS08900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP84_RS08905	COG1993	acr, cog1993
HEP84_RS08910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEP84_RS08935	COG0395	ABC-type sugar transport system, permease component
HEP84_RS08955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEP84_RS08985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP84_RS09020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HEP84_RS09025	COG1215	transferase activity, transferring glycosyl groups
HEP84_RS09040	COG3217	Mosc domain protein beta barrel domain protein
HEP84_RS09040	COG0633	Ferredoxin
HEP84_RS09060	COG1349	DNA-binding transcription factor activity
HEP84_RS09085	COG0577	efflux transmembrane transporter activity
HEP84_RS09090	COG1136	(ABC) transporter
HEP84_RS09125	COG2813	Specifically methylates the guanine in position
HEP84_RS09150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP84_RS09155	COG1349	DNA-binding transcription factor activity
HEP84_RS09160	COG3537	Alpha-1,2-mannosidase
HEP84_RS09170	COG1174	glycine betaine transport
HEP84_RS09190	COG2018	Roadblock/LC7 domain
HEP84_RS09210	COG2267	carboxylic ester hydrolase activity
HEP84_RS09220	COG3320	Male sterility
HEP84_RS09220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP84_RS09240	COG0596	Alpha beta hydrolase
HEP84_RS09245	COG4565	transcriptional regulatory protein
HEP84_RS09250	COG3290	protein histidine kinase activity
HEP84_RS09260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS09295	COG1271	oxidase subunit
HEP84_RS09305	COG3265	gluconokinase activity
HEP84_RS09350	COG3387	PFAM Glycoside hydrolase 15-related
HEP84_RS09365	COG2223	nitrite transmembrane transporter activity
HEP84_RS09390	COG2197	response regulator
HEP84_RS09395	COG4585	Histidine kinase
HEP84_RS09410	COG0445	tRNA wobble uridine modification
HEP84_RS09415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP84_RS09420	COG1660	Displays ATPase and GTPase activities
HEP84_RS09440	COG0395	ABC-type sugar transport system, permease component
HEP84_RS09455	COG3345	alpha-galactosidase
HEP84_RS09485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEP84_RS09510	COG0204	Acyl-transferase
HEP84_RS09535	COG0584	glycerophosphoryl diester phosphodiesterase
HEP84_RS09580	COG0671	phosphoesterase, PA-phosphatase related
HEP84_RS09595	COG1309	transcriptional regulator
HEP84_RS09615	COG2233	PERMEase
HEP84_RS09620	COG0640	Transcriptional regulator
HEP84_RS09625	COG1902	pentaerythritol trinitrate reductase activity
HEP84_RS09640	COG2197	response regulator
HEP84_RS09645	COG4585	Histidine kinase
HEP84_RS09650	COG3963	phosphatidate phosphatase activity
HEP84_RS09670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP84_RS09670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP84_RS09720	COG0714	Associated with various cellular activities
HEP84_RS09755	COG0596	Alpha beta hydrolase
HEP84_RS09760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEP84_RS09760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEP84_RS09765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP84_RS09770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP84_RS09780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP84_RS09795	COG2706	6-phosphogluconolactonase activity
HEP84_RS09800	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HEP84_RS09830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP84_RS09840	COG2080	2 iron, 2 sulfur cluster binding
HEP84_RS09855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP84_RS09865	COG2770	Histidine kinase
HEP84_RS09865	COG2208	phosphoserine phosphatase activity
HEP84_RS09885	COG0745	RESPONSE REGULATOR receiver
HEP84_RS09985	COG0667	Aldo Keto reductase
HEP84_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS10020	COG0513	Belongs to the DEAD box helicase family
HEP84_RS10045	COG0432	Pfam Uncharacterised protein family UPF0047
HEP84_RS10050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS10055	COG1116	anion transmembrane transporter activity
HEP84_RS10065	COG2072	flavoprotein involved in K transport
HEP84_RS10075	COG1132	(ABC) transporter
HEP84_RS10085	COG1301	dicarboxylic acid transport
HEP84_RS10105	COG1132	(ABC) transporter
HEP84_RS10115	COG0254	rRNA binding
HEP84_RS10130	COG1946	Acyl-CoA thioesterase
HEP84_RS10145	COG2018	Roadblock/LC7 domain
HEP84_RS10185	COG2267	carboxylic ester hydrolase activity
HEP84_RS10210	COG3239	Fatty acid desaturase
HEP84_RS10215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEP84_RS10235	COG2115	Belongs to the xylose isomerase family
HEP84_RS10245	COG1846	Transcriptional regulator
HEP84_RS10245	COG1940	carbohydrate kinase activity
HEP84_RS10250	COG1113	amino acid transport
HEP84_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS10280	COG1309	transcriptional regulator
HEP84_RS10325	COG2182	Extracellular solute-binding protein
HEP84_RS10355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP84_RS10360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP84_RS10375	COG4176	ABC-type proline glycine betaine transport system permease component
HEP84_RS10380	COG4175	Glycine betaine
HEP84_RS10380	COG0517	IMP dehydrogenase activity
HEP84_RS10385	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS10400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HEP84_RS10410	COG4638	Rieske (2fe-2S)
HEP84_RS10415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP84_RS10420	COG2146	nitrite reductase [NAD(P)H] activity
HEP84_RS10425	COG1760	l-serine dehydratase
HEP84_RS10485	COG0515	serine threonine protein kinase
HEP84_RS10510	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS10515	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS10530	COG0492	ferredoxin-NADP+ reductase activity
HEP84_RS10535	COG1793	dna ligase
HEP84_RS10545	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS10560	COG3424	synthase
HEP84_RS10565	COG2124	cytochrome p450
HEP84_RS10575	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS10585	COG0242	peptide deformylase activity
HEP84_RS10595	COG3442	glutamine amidotransferase
HEP84_RS10600	COG0205	6-phosphofructokinase activity
HEP84_RS10615	COG0515	serine threonine protein kinase
HEP84_RS10615	COG2815	serine threonine protein kinase
HEP84_RS10625	COG3275	phosphorelay sensor kinase activity
HEP84_RS10630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP84_RS10640	COG3279	Response regulator of the LytR AlgR family
HEP84_RS10650	COG1834	amidinotransferase
HEP84_RS10655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP84_RS10665	COG1733	regulation of RNA biosynthetic process
HEP84_RS10680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HEP84_RS10705	COG0829	nickel cation binding
HEP84_RS10710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP84_RS10725	COG0832	Belongs to the urease beta subunit family
HEP84_RS10730	COG0831	urea catabolic process
HEP84_RS10740	COG0740	serine-type endopeptidase activity
HEP84_RS10785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HEP84_RS10790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP84_RS10795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEP84_RS10810	COG2226	methyltransferase
HEP84_RS10840	COG0456	acetyltransferase
HEP84_RS10900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEP84_RS10905	COG3663	DNA glycosylase
HEP84_RS10930	COG1940	carbohydrate kinase activity
HEP84_RS10935	COG2188	Transcriptional regulator
HEP84_RS10940	COG1595	DNA-templated transcription, initiation
HEP84_RS10955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP84_RS10970	COG0626	cystathionine gamma-synthase activity
HEP84_RS10990	COG0583	DNA-binding transcription factor activity
HEP84_RS11000	COG1522	sequence-specific DNA binding
HEP84_RS11010	COG0420	3'-5' exonuclease activity
HEP84_RS11015	COG1739	Uncharacterized protein family UPF0029
HEP84_RS11035	COG2197	response regulator
HEP84_RS11045	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS11065	COG1832	CoA-binding protein
HEP84_RS11100	COG2326	polyphosphate kinase activity
HEP84_RS11105	COG0640	Transcriptional regulator
HEP84_RS11130	COG0110	maltose O-acetyltransferase activity
HEP84_RS11165	COG1609	Transcriptional regulator
HEP84_RS11210	COG3835	regulator
HEP84_RS11215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP84_RS11215	COG2010	Cytochrome c
HEP84_RS11220	COG2080	2 iron, 2 sulfur cluster binding
HEP84_RS11225	COG3608	succinylglutamate desuccinylase aspartoacylase
HEP84_RS11225	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEP84_RS11330	COG0667	Aldo Keto reductase
HEP84_RS11410	COG1231	oxidoreductase activity
HEP84_RS11510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP84_RS11525	COG0183	Belongs to the thiolase family
HEP84_RS11550	COG1968	undecaprenyl-diphosphatase activity
HEP84_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS11585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS11595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEP84_RS11605	COG2318	DinB family
HEP84_RS11615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HEP84_RS11620	COG0747	negative chemotaxis
HEP84_RS11665	COG0697	spore germination
HEP84_RS11700	COG1695	Transcriptional regulator
HEP84_RS11740	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP84_RS11740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HEP84_RS11750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP84_RS11770	COG1716	ATPase activity
HEP84_RS11790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP84_RS11820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP84_RS11835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP84_RS11840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP84_RS11850	COG2816	NAD+ diphosphatase activity
HEP84_RS11855	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HEP84_RS11865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP84_RS11875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP84_RS11880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP84_RS11900	COG2018	Roadblock/LC7 domain
HEP84_RS11950	COG2814	Major facilitator Superfamily
HEP84_RS11955	COG4336	lyase activity
HEP84_RS11960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HEP84_RS11970	COG1984	allophanate hydrolase subunit 2
HEP84_RS11980	COG0438	transferase activity, transferring glycosyl groups
HEP84_RS11985	COG0438	transferase activity, transferring glycosyl groups
HEP84_RS12025	COG2270	Major facilitator Superfamily
HEP84_RS12040	COG0463	Glycosyl transferase, family 2
HEP84_RS12075	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS12085	COG1309	transcriptional regulator
HEP84_RS12130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HEP84_RS12135	COG0140	phosphoribosyl-ATP diphosphatase activity
HEP84_RS12140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HEP84_RS12145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP84_RS12145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP84_RS12150	COG3201	nicotinamide mononucleotide transporter
HEP84_RS12160	COG1846	Transcriptional regulator
HEP84_RS12160	COG1940	carbohydrate kinase activity
HEP84_RS12165	COG2223	nitrite transmembrane transporter activity
HEP84_RS12180	COG2233	PERMEase
HEP84_RS12205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP84_RS12230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP84_RS12235	COG3842	ATPase activity
HEP84_RS12245	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP84_RS12255	COG2188	Transcriptional regulator
HEP84_RS12285	COG2390	Transcriptional regulator
HEP84_RS12290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEP84_RS12300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP84_RS12315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HEP84_RS12330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP84_RS12345	COG0194	GDP metabolic process
HEP84_RS12355	COG0284	orotidine-5'-phosphate decarboxylase activity
HEP84_RS12360	COG0167	dihydroorotate dehydrogenase activity
HEP84_RS12365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HEP84_RS12370	COG0505	Belongs to the CarA family
HEP84_RS12380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP84_RS12385	COG0540	Belongs to the ATCase OTCase family
HEP84_RS12390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HEP84_RS12400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEP84_RS12405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HEP84_RS12420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HEP84_RS12425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEP84_RS12430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HEP84_RS12435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HEP84_RS12440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEP84_RS12445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HEP84_RS12450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HEP84_RS12470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HEP84_RS12485	COG1131	(ABC) transporter
HEP84_RS12495	COG4585	Histidine kinase
HEP84_RS12500	COG2197	response regulator
HEP84_RS12505	COG0124	histidyl-tRNA synthetase
HEP84_RS12515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEP84_RS12520	COG1196	nuclear chromosome segregation
HEP84_RS12525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP84_RS12530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HEP84_RS12535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP84_RS12540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEP84_RS12550	COG2255	four-way junction helicase activity
HEP84_RS12555	COG0632	four-way junction helicase activity
HEP84_RS12560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HEP84_RS12565	COG0217	transcriptional regulatory protein
HEP84_RS12570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HEP84_RS12575	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HEP84_RS12590	COG0438	transferase activity, transferring glycosyl groups
HEP84_RS12600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEP84_RS12620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEP84_RS12625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEP84_RS12640	COG5002	protein histidine kinase activity
HEP84_RS12640	COG2176	DNA-directed DNA polymerase activity
HEP84_RS12670	COG0395	ABC-type sugar transport system, permease component
HEP84_RS12675	COG1175	transmembrane transport
HEP84_RS12810	COG1464	Belongs to the NlpA lipoprotein family
HEP84_RS12815	COG2011	ABC-type metal ion transport system permease component
HEP84_RS12820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP84_RS12860	COG0204	Acyl-transferase
HEP84_RS12860	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS12865	COG0477	Major facilitator Superfamily
HEP84_RS12880	COG0165	Argininosuccinate lyase
HEP84_RS12885	COG0137	argininosuccinate synthase activity
HEP84_RS12905	COG2205	protein histidine kinase activity
HEP84_RS12910	COG0745	RESPONSE REGULATOR receiver
HEP84_RS12915	COG0543	2 iron, 2 sulfur cluster binding
HEP84_RS12940	COG1438	arginine binding
HEP84_RS12945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP84_RS12950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEP84_RS12955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HEP84_RS12960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEP84_RS12980	COG0778	Nitroreductase
HEP84_RS12985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP84_RS12995	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP84_RS13065	COG0789	Transcriptional regulator
HEP84_RS13115	COG0697	spore germination
HEP84_RS13125	COG1649	PFAM Uncharacterised BCR, COG1649
HEP84_RS13160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HEP84_RS13165	COG5002	protein histidine kinase activity
HEP84_RS13170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP84_RS13175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HEP84_RS13180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HEP84_RS13185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HEP84_RS13235	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS13240	COG0174	glutamine synthetase
HEP84_RS13250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEP84_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS13275	COG0431	NADPH-dependent FMN reductase
HEP84_RS13305	COG4176	ABC-type proline glycine betaine transport system permease component
HEP84_RS13310	COG0517	IMP dehydrogenase activity
HEP84_RS13310	COG4175	Glycine betaine
HEP84_RS13315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP84_RS13345	COG0564	pseudouridine synthase activity
HEP84_RS13375	COG1309	transcriptional regulator
HEP84_RS13415	COG0805	protein transport
HEP84_RS13420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP84_RS13450	COG0545	Peptidyl-prolyl cis-trans isomerase
HEP84_RS13455	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP84_RS13465	COG1609	Transcriptional regulator
HEP84_RS13470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP84_RS13475	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HEP84_RS13490	COG4122	O-methyltransferase activity
HEP84_RS13495	COG1222	aaa ATPase
HEP84_RS13520	COG1994	Peptidase M50
HEP84_RS13520	COG0517	IMP dehydrogenase activity
HEP84_RS13530	COG2197	response regulator
HEP84_RS13540	COG4166	transmembrane transport
HEP84_RS13550	COG0646	methionine synthase
HEP84_RS13550	COG1410	methionine synthase
HEP84_RS13555	COG1414	Transcriptional regulator
HEP84_RS13560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEP84_RS13565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP84_RS13570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP84_RS13575	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HEP84_RS13585	COG1129	ABC transporter
HEP84_RS13595	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HEP84_RS13600	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HEP84_RS13605	COG0235	Class ii aldolase
HEP84_RS13610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP84_RS13610	COG0235	Class ii aldolase
HEP84_RS13635	COG0813	purine-nucleoside phosphorylase activity
HEP84_RS13640	COG0402	S-adenosylhomocysteine deaminase activity
HEP84_RS13645	COG2186	Transcriptional regulator
HEP84_RS13670	COG0215	cysteine-tRNA ligase activity
HEP84_RS13690	COG0598	Magnesium transport protein CorA
HEP84_RS13700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS13705	COG0667	Aldo Keto reductase
HEP84_RS13710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP84_RS13735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP84_RS13750	COG0308	aminopeptidase N
HEP84_RS13755	COG3012	SEC-C Motif Domain Protein
HEP84_RS13760	COG2186	Transcriptional regulator
HEP84_RS13765	COG3265	gluconokinase activity
HEP84_RS13775	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS13780	COG1063	alcohol dehydrogenase
HEP84_RS13805	COG3573	Dehydrogenase
HEP84_RS13815	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP84_RS13820	COG2149	membrane
HEP84_RS13850	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS13860	COG3876	Protein conserved in bacteria
HEP84_RS13880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP84_RS13880	COG0072	phenylalanine-tRNA ligase activity
HEP84_RS13885	COG0789	Transcriptional regulator
HEP84_RS13905	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS13915	COG0640	Transcriptional regulator
HEP84_RS13920	COG0697	spore germination
HEP84_RS13945	COG2851	Citrate transporter
HEP84_RS13950	COG0243	molybdopterin cofactor binding
HEP84_RS13955	COG1309	transcriptional regulator
HEP84_RS13965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HEP84_RS13970	COG2188	Transcriptional regulator
HEP84_RS14010	COG1595	DNA-templated transcription, initiation
HEP84_RS14035	COG2755	lipolytic protein G-D-S-L family
HEP84_RS14060	COG0726	polysaccharide deacetylase
HEP84_RS14060	COG1649	PFAM Uncharacterised BCR, COG1649
HEP84_RS14085	COG1725	Transcriptional regulator
HEP84_RS14125	COG0662	Cupin 2, conserved barrel domain protein
HEP84_RS14125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEP84_RS14130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HEP84_RS14135	COG0587	DNA-directed DNA polymerase activity
HEP84_RS14145	COG0330	HflC and HflK could
HEP84_RS14170	COG1126	abc transporter atp-binding protein
HEP84_RS14180	COG0765	amino acid transport
HEP84_RS14205	COG1799	cell septum assembly
HEP84_RS14210	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS14215	COG0477	Major facilitator Superfamily
HEP84_RS14225	COG0671	phosphoesterase, PA-phosphatase related
HEP84_RS14235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP84_RS14295	COG1160	GTP binding
HEP84_RS14305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HEP84_RS14340	COG3541	Predicted nucleotidyltransferase
HEP84_RS14355	COG1187	pseudouridine synthase activity
HEP84_RS14360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HEP84_RS14380	COG0686	Belongs to the AlaDH PNT family
HEP84_RS14390	COG0494	nUDIX hydrolase
HEP84_RS14395	COG0504	CTP synthase activity
HEP84_RS14400	COG3387	PFAM Glycoside hydrolase 15-related
HEP84_RS14420	COG0497	DNA recombination
HEP84_RS14425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HEP84_RS14445	COG1120	ATPase activity
HEP84_RS14450	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP84_RS14455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP84_RS14460	COG0647	UMP catabolic process
HEP84_RS14490	COG2094	Belongs to the DNA glycosylase MPG family
HEP84_RS14500	COG1881	PFAM PEBP family protein
HEP84_RS14520	COG1119	ATPase activity
HEP84_RS14535	COG2197	response regulator
HEP84_RS14545	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS14550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEP84_RS14560	COG0842	Transport permease protein
HEP84_RS14560	COG1131	(ABC) transporter
HEP84_RS14560	COG1716	ATPase activity
HEP84_RS14570	COG0560	Phosphoserine phosphatase
HEP84_RS14570	COG3830	Belongs to the UPF0237 family
HEP84_RS14575	COG0588	phosphoglycerate mutase activity
HEP84_RS14590	COG2186	Transcriptional regulator
HEP84_RS14600	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEP84_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS14620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HEP84_RS14640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP84_RS14645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP84_RS14665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP84_RS14715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP84_RS14730	COG3387	PFAM Glycoside hydrolase 15-related
HEP84_RS14780	COG0488	(ABC) transporter
HEP84_RS14810	COG0235	Class ii aldolase
HEP84_RS14830	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HEP84_RS14835	COG1492	cobalamin metabolic process
HEP84_RS14850	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HEP84_RS14855	COG1797	cobyrinic acid a,c-diamide synthase activity
HEP84_RS14890	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HEP84_RS14910	COG1126	abc transporter atp-binding protein
HEP84_RS14915	COG0765	amino acid transport
HEP84_RS14920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP84_RS14925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HEP84_RS14930	COG0456	acetyltransferase
HEP84_RS14935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEP84_RS14940	COG1917	Cupin 2, conserved barrel domain protein
HEP84_RS14945	COG5285	phytanoyl-CoA dioxygenase
HEP84_RS14975	COG1414	Transcriptional regulator
HEP84_RS14985	COG0768	penicillin binding
HEP84_RS14990	COG2252	PERMEase
HEP84_RS14995	COG1595	DNA-templated transcription, initiation
HEP84_RS15010	COG4733	cellulase activity
HEP84_RS15055	COG4677	pectinesterase activity
HEP84_RS15060	COG3866	Pectate lyase
HEP84_RS15065	COG2755	lipolytic protein G-D-S-L family
HEP84_RS15070	COG1653	transport
HEP84_RS15090	COG0395	ABC-type sugar transport system, permease component
HEP84_RS15105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP84_RS15110	COG1802	Transcriptional regulator
HEP84_RS15130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP84_RS15135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP84_RS15140	COG1349	DNA-binding transcription factor activity
HEP84_RS15155	COG0395	ABC-type sugar transport system, permease component
HEP84_RS15160	COG1063	alcohol dehydrogenase
HEP84_RS15170	COG1309	transcriptional regulator
HEP84_RS15185	COG1802	Transcriptional regulator
HEP84_RS15225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP84_RS15240	COG1819	glycosyl
HEP84_RS15245	COG3973	AAA domain
HEP84_RS15250	COG1063	alcohol dehydrogenase
HEP84_RS15255	COG2171	N-acyltransferase activity
HEP84_RS15260	COG3226	Transcriptional regulator
HEP84_RS15265	COG2076	Multidrug Resistance protein
HEP84_RS15285	COG0822	iron-sulfur transferase activity
HEP84_RS15290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP84_RS15295	COG0396	ATPase activity
HEP84_RS15305	COG0719	Fe-S assembly protein
HEP84_RS15320	COG2746	aminoglycoside 3-N-acetyltransferase activity
HEP84_RS15325	COG1131	(ABC) transporter
HEP84_RS15350	COG0109	protoheme IX farnesyltransferase activity
HEP84_RS15360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP84_RS15375	COG0363	glucosamine-6-phosphate deaminase activity
HEP84_RS15380	COG0395	ABC-type sugar transport system, permease component
HEP84_RS15385	COG1175	transmembrane transport
HEP84_RS15395	COG0366	Alpha amylase catalytic
HEP84_RS15400	COG1653	transport
HEP84_RS15405	COG1695	Transcriptional regulator
HEP84_RS15410	COG1136	(ABC) transporter
HEP84_RS15425	COG0166	Belongs to the GPI family
HEP84_RS15440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEP84_RS15445	COG0149	triose-phosphate isomerase activity
HEP84_RS15450	COG0126	phosphoglycerate kinase activity
HEP84_RS15455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP84_RS15465	COG1481	regulation of sporulation
HEP84_RS15470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP84_RS15475	COG1660	Displays ATPase and GTPase activities
HEP84_RS15480	COG0322	excinuclease ABC activity
HEP84_RS15495	COG1609	Transcriptional regulator
HEP84_RS15505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP84_RS15520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP84_RS15525	COG0765	amino acid transport
HEP84_RS15535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEP84_RS15540	COG0477	Major facilitator Superfamily
HEP84_RS15545	COG0387	Pfam Sodium calcium exchanger
HEP84_RS15565	COG0556	nucleotide-excision repair
HEP84_RS15575	COG0584	glycerophosphoryl diester phosphodiesterase
HEP84_RS15580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP84_RS15600	COG2313	pseudouridylate synthase activity
HEP84_RS15610	COG2226	methyltransferase
HEP84_RS15615	COG0598	Magnesium transport protein CorA
HEP84_RS15645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS15650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP84_RS15690	COG2124	cytochrome p450
HEP84_RS15695	COG0402	S-adenosylhomocysteine deaminase activity
HEP84_RS15730	COG1953	Uracil, thiamine, allantoin
HEP84_RS15740	COG1802	Transcriptional regulator
HEP84_RS15745	COG2267	carboxylic ester hydrolase activity
HEP84_RS15785	COG0237	dephospho-CoA kinase activity
HEP84_RS15805	COG2226	methyltransferase
HEP84_RS15850	COG2050	protein possibly involved in aromatic compounds catabolism
HEP84_RS15910	COG0737	Belongs to the 5'-nucleotidase family
HEP84_RS15930	COG0745	RESPONSE REGULATOR receiver
HEP84_RS15935	COG1605	Chorismate mutase
HEP84_RS15935	COG0287	Prephenate dehydrogenase
HEP84_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS15975	COG1024	Enoyl-CoA hydratase
HEP84_RS15995	COG0183	Belongs to the thiolase family
HEP84_RS16000	COG1309	transcriptional regulator
HEP84_RS16010	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS16015	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS16020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP84_RS16030	COG2304	oxidoreductase activity
HEP84_RS16045	COG1136	(ABC) transporter
HEP84_RS16045	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEP84_RS16060	COG0577	efflux transmembrane transporter activity
HEP84_RS16060	COG1136	(ABC) transporter
HEP84_RS16070	COG0067	glutamate synthase
HEP84_RS16070	COG0070	glutamate synthase
HEP84_RS16070	COG0069	glutamate synthase activity
HEP84_RS16100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS16105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP84_RS16110	COG2301	Belongs to the HpcH HpaI aldolase family
HEP84_RS16125	COG0159	tryptophan synthase activity
HEP84_RS16130	COG0133	tryptophan synthase activity
HEP84_RS16140	COG0134	indole-3-glycerol-phosphate synthase activity
HEP84_RS16165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HEP84_RS16185	COG0107	imidazoleglycerol-phosphate synthase activity
HEP84_RS16190	COG0251	oxidation-reduction process
HEP84_RS16195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HEP84_RS16200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HEP84_RS16210	COG0131	Imidazoleglycerol-phosphate dehydratase
HEP84_RS16215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP84_RS16220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEP84_RS16240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEP84_RS16260	COG1432	Conserved Protein
HEP84_RS16270	COG0587	DNA-directed DNA polymerase activity
HEP84_RS16315	COG2153	protein acetylation
HEP84_RS16325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HEP84_RS16340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HEP84_RS16345	COG3599	regulation of cell shape
HEP84_RS16355	COG1799	cell septum assembly
HEP84_RS16370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEP84_RS16380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HEP84_RS16390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEP84_RS16395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP84_RS16405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEP84_RS16420	COG0275	rRNA processing
HEP84_RS16430	COG0714	Associated with various cellular activities
HEP84_RS16450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP84_RS16470	COG1309	transcriptional regulator
HEP84_RS16510	COG2022	thiamine diphosphate biosynthetic process
HEP84_RS16510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP84_RS16520	COG2022	thiamine diphosphate biosynthetic process
HEP84_RS16525	COG2815	serine threonine protein kinase
HEP84_RS16525	COG0515	serine threonine protein kinase
HEP84_RS16530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HEP84_RS16535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEP84_RS16540	COG2193	ferroxidase activity
HEP84_RS16545	COG0243	molybdopterin cofactor binding
HEP84_RS16550	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP84_RS16570	COG0205	6-phosphofructokinase activity
HEP84_RS16580	COG4585	Histidine kinase
HEP84_RS16605	COG1940	carbohydrate kinase activity
HEP84_RS16650	COG0534	Mate efflux family protein
HEP84_RS16670	COG1388	LysM domain
HEP84_RS16670	COG3103	Sh3 type 3 domain protein
HEP84_RS16670	COG0791	NLP P60 protein
HEP84_RS16695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP84_RS16700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEP84_RS16705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP84_RS16710	COG0723	plastoquinol--plastocyanin reductase activity
HEP84_RS16715	COG2010	Cytochrome c
HEP84_RS16720	COG1845	cytochrome c oxidase, subunit III
HEP84_RS16730	COG1376	ErfK ybiS ycfS ynhG family protein
HEP84_RS16740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP84_RS16745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEP84_RS16755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS16775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HEP84_RS16780	COG2197	response regulator
HEP84_RS16810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP84_RS16830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HEP84_RS16835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP84_RS16835	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP84_RS16850	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HEP84_RS16855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEP84_RS16860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP84_RS16865	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP84_RS16880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP84_RS16910	COG1090	epimerase
HEP84_RS16925	COG0321	lipoyl(octanoyl) transferase activity
HEP84_RS16930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEP84_RS16950	COG0174	glutamine synthetase
HEP84_RS16960	COG0501	Belongs to the peptidase M48B family
HEP84_RS17015	COG0745	RESPONSE REGULATOR receiver
HEP84_RS17030	COG2197	response regulator
HEP84_RS17065	COG1309	transcriptional regulator
HEP84_RS17100	COG1175	transmembrane transport
HEP84_RS17105	COG3833	ABC-type maltose transport systems, permease component
HEP84_RS17110	COG0366	Alpha amylase catalytic
HEP84_RS17115	COG1609	Transcriptional regulator
HEP84_RS17130	COG0583	DNA-binding transcription factor activity
HEP84_RS17135	COG0697	spore germination
HEP84_RS17140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP84_RS17145	COG3511	phospholipase C
HEP84_RS17200	COG0174	glutamine synthetase
HEP84_RS17205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP84_RS17205	COG1017	nitric oxide dioxygenase activity
HEP84_RS17210	COG1959	2 iron, 2 sulfur cluster binding
HEP84_RS17230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HEP84_RS17230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEP84_RS17235	COG2814	Major facilitator Superfamily
HEP84_RS17250	COG0477	Major facilitator Superfamily
HEP84_RS17255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HEP84_RS17275	COG1994	Peptidase M50
HEP84_RS17325	COG2822	iron ion transport
HEP84_RS17330	COG2837	iron assimilation
HEP84_RS17335	COG0672	)-iron permease
HEP84_RS17345	COG0495	leucyl-tRNA aminoacylation
HEP84_RS17355	COG1834	amidinotransferase
HEP84_RS17365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP84_RS17370	COG2814	Major facilitator Superfamily
HEP84_RS17395	COG1136	(ABC) transporter
HEP84_RS17405	COG2259	Doxx family
HEP84_RS17420	COG0406	alpha-ribazole phosphatase activity
HEP84_RS17425	COG1609	Transcriptional regulator
HEP84_RS17430	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS17435	COG0673	inositol 2-dehydrogenase activity
HEP84_RS17470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEP84_RS17505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEP84_RS17555	COG3022	response to hydroperoxide
HEP84_RS17560	COG0800	Aldolase
HEP84_RS17585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HEP84_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS17610	COG2030	dehydratase
HEP84_RS17615	COG1131	(ABC) transporter
HEP84_RS17635	COG2197	response regulator
HEP84_RS17655	COG0183	Belongs to the thiolase family
HEP84_RS17660	COG0477	Major facilitator Superfamily
HEP84_RS17680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS17710	COG1309	transcriptional regulator
HEP84_RS17790	COG3619	membrane
HEP84_RS17815	COG0183	Belongs to the thiolase family
HEP84_RS17820	COG2124	cytochrome p450
HEP84_RS17840	COG4122	O-methyltransferase activity
HEP84_RS17930	COG1335	isochorismatase
HEP84_RS17935	COG0477	Major facilitator Superfamily
HEP84_RS17985	COG5640	endopeptidase activity
HEP84_RS18030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP84_RS18045	COG1358	cellular component organization or biogenesis
HEP84_RS18090	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEP84_RS18095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP84_RS18100	COG0477	Major facilitator Superfamily
HEP84_RS18105	COG1309	transcriptional regulator
HEP84_RS18120	COG0667	Aldo Keto reductase
HEP84_RS18125	COG0789	Transcriptional regulator
HEP84_RS18140	COG1741	Belongs to the pirin family
HEP84_RS18155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP84_RS18160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP84_RS18165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP84_RS18195	COG1309	transcriptional regulator
HEP84_RS18210	COG2084	Dehydrogenase
HEP84_RS18240	COG1764	response to oxidative stress
HEP84_RS18245	COG2130	NADP-dependent
HEP84_RS18260	COG4948	Mandelate Racemase Muconate Lactonizing
HEP84_RS18285	COG4214	carbohydrate transport
HEP84_RS18295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP84_RS18330	COG1764	response to oxidative stress
HEP84_RS18360	COG0596	Alpha beta hydrolase
HEP84_RS18380	COG2318	DinB family
HEP84_RS18410	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP84_RS18415	COG0395	ABC-type sugar transport system, permease component
HEP84_RS18420	COG1175	transmembrane transport
HEP84_RS18430	COG3386	PFAM SMP-30 Gluconolaconase
HEP84_RS18435	COG1414	Transcriptional regulator
HEP84_RS18465	COG4981	capsule polysaccharide biosynthetic process
HEP84_RS18535	COG0825	malonyl-CoA metabolic process
HEP84_RS18535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HEP84_RS18545	COG1077	Cell shape determining protein MreB Mrl
HEP84_RS18590	COG0559	Belongs to the binding-protein-dependent transport system permease family
HEP84_RS18610	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS18645	COG1070	Carbohydrate kinase
HEP84_RS18660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP84_RS18665	COG0358	DNA primase activity
HEP84_RS18675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HEP84_RS18685	COG3547	Transposase (IS116 IS110 IS902 family)
HEP84_RS18690	COG2949	membrane
HEP84_RS18740	COG2197	response regulator
HEP84_RS18755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEP84_RS18755	COG2146	nitrite reductase [NAD(P)H] activity
HEP84_RS18765	COG1309	transcriptional regulator
HEP84_RS18770	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS18795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP84_RS18795	COG0574	Belongs to the PEP-utilizing enzyme family
HEP84_RS18800	COG1940	carbohydrate kinase activity
HEP84_RS18800	COG1846	Transcriptional regulator
HEP84_RS18830	COG0477	Major facilitator Superfamily
HEP84_RS18835	COG1595	DNA-templated transcription, initiation
HEP84_RS18870	COG0667	Aldo Keto reductase
HEP84_RS18880	COG1309	transcriptional regulator
HEP84_RS18885	COG0300	oxidoreductase activity
HEP84_RS18890	COG1595	DNA-templated transcription, initiation
HEP84_RS18920	COG0423	glycine-tRNA ligase activity
HEP84_RS18925	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEP84_RS18930	COG1121	(ABC) transporter
HEP84_RS18935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEP84_RS18945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP84_RS18950	COG1381	Involved in DNA repair and RecF pathway recombination
HEP84_RS18980	COG0515	serine threonine protein kinase
HEP84_RS18980	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP84_RS18985	COG2197	response regulator
HEP84_RS18990	COG4585	Histidine kinase
HEP84_RS18995	COG1131	(ABC) transporter
HEP84_RS19010	COG2186	Transcriptional regulator
HEP84_RS19015	COG0747	negative chemotaxis
HEP84_RS19025	COG0444	Belongs to the ABC transporter superfamily
HEP84_RS19030	COG4608	Belongs to the ABC transporter superfamily
HEP84_RS19035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP84_RS19050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP84_RS19070	COG2723	6-phospho-beta-galactosidase activity
HEP84_RS19115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEP84_RS19135	COG2315	Protein conserved in bacteria
HEP84_RS19145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEP84_RS19170	COG1470	cell adhesion involved in biofilm formation
HEP84_RS19170	COG0366	Alpha amylase catalytic
HEP84_RS19195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP84_RS19200	COG1234	tRNA 3'-trailer cleavage
HEP84_RS19205	COG0537	adenosine 5'-monophosphoramidase activity
HEP84_RS19210	COG4946	Tricorn protease homolog
HEP84_RS19210	COG0793	Belongs to the peptidase S41A family
HEP84_RS19235	COG0484	heat shock protein binding
HEP84_RS19240	COG1420	regulation of RNA biosynthetic process
HEP84_RS19280	COG0481	GTPase activity
HEP84_RS19290	COG0268	Binds directly to 16S ribosomal RNA
HEP84_RS19315	COG1555	photosystem II stabilization
HEP84_RS19320	COG1307	EDD domain protein, DegV family
HEP84_RS19330	COG0495	leucyl-tRNA aminoacylation
HEP84_RS19365	COG0477	Major facilitator Superfamily
HEP84_RS19380	COG0588	phosphoglycerate mutase activity
HEP84_RS19385	COG0799	negative regulation of ribosome biogenesis
HEP84_RS19395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HEP84_RS19410	COG0501	Belongs to the peptidase M48B family
HEP84_RS19425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HEP84_RS19435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEP84_RS19465	COG3540	Alkaline phosphatase
HEP84_RS19470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP84_RS19475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HEP84_RS19480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEP84_RS19515	COG0076	glutamate decarboxylase activity
HEP84_RS19525	COG1309	transcriptional regulator
HEP84_RS19530	COG4221	oxidoreductase activity
HEP84_RS19555	COG0772	Belongs to the SEDS family
HEP84_RS19575	COG1077	Cell shape determining protein MreB Mrl
HEP84_RS19580	COG0105	UTP biosynthetic process
HEP84_RS19590	COG0285	dihydrofolate synthase activity
HEP84_RS19595	COG0525	valine-tRNA ligase activity
HEP84_RS19620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HEP84_RS19625	COG0740	serine-type endopeptidase activity
HEP84_RS19630	COG0740	serine-type endopeptidase activity
HEP84_RS19635	COG0544	peptidyl-prolyl cis-trans isomerase activity
HEP84_RS19655	COG3594	Acyltransferase
HEP84_RS19670	COG4552	Acetyltransferase involved in intracellular survival and related
HEP84_RS19685	COG1113	amino acid transport
HEP84_RS19700	COG1268	BioY protein
HEP84_RS19705	COG1940	carbohydrate kinase activity
HEP84_RS19715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS19720	COG1116	anion transmembrane transporter activity
HEP84_RS19725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS19740	COG1113	amino acid transport
HEP84_RS19750	COG0588	phosphoglycerate mutase activity
HEP84_RS19760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP84_RS19845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEP84_RS19875	COG0697	spore germination
HEP84_RS19890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP84_RS19915	COG1595	DNA-templated transcription, initiation
HEP84_RS19925	COG1131	(ABC) transporter
HEP84_RS19945	COG0668	transmembrane transport
HEP84_RS19965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP84_RS19975	COG0765	amino acid transport
HEP84_RS19985	COG3835	regulator
HEP84_RS20000	COG1175	transmembrane transport
HEP84_RS20005	COG0395	ABC-type sugar transport system, permease component
HEP84_RS20010	COG1486	melibiose metabolic process
HEP84_RS20025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP84_RS20055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP84_RS20060	COG2346	COG2346, Truncated hemoglobins
HEP84_RS20105	COG0577	efflux transmembrane transporter activity
HEP84_RS20110	COG1136	(ABC) transporter
HEP84_RS20110	COG0577	efflux transmembrane transporter activity
HEP84_RS20155	COG0629	single-stranded DNA binding
HEP84_RS20265	COG3962	Belongs to the TPP enzyme family
HEP84_RS20270	COG3718	enzyme involved in inositol metabolism
HEP84_RS20280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS20305	COG2409	Drug exporters of the RND superfamily
HEP84_RS20335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEP84_RS20350	COG1129	ABC transporter
HEP84_RS20360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS20365	COG1869	D-ribose catabolic process
HEP84_RS20385	COG0673	inositol 2-dehydrogenase activity
HEP84_RS20390	COG1609	Transcriptional regulator
HEP84_RS20400	COG0456	acetyltransferase
HEP84_RS20400	COG1846	Transcriptional regulator
HEP84_RS20420	COG0181	hydroxymethylbilane synthase activity
HEP84_RS20425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEP84_RS20430	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP84_RS20500	COG2356	endonuclease I
HEP84_RS20505	COG0028	Belongs to the TPP enzyme family
HEP84_RS20515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP84_RS20535	COG1136	(ABC) transporter
HEP84_RS20550	COG1946	Acyl-CoA thioesterase
HEP84_RS20565	COG1309	transcriptional regulator
HEP84_RS20570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP84_RS20585	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS20615	COG0076	glutamate decarboxylase activity
HEP84_RS20620	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HEP84_RS20655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP84_RS20665	COG0589	response to stress
HEP84_RS20675	COG4977	sequence-specific DNA binding
HEP84_RS20680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEP84_RS20715	COG0395	ABC-type sugar transport system, permease component
HEP84_RS20730	COG3979	chitinase
HEP84_RS20765	COG0406	alpha-ribazole phosphatase activity
HEP84_RS20815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS20830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP84_RS20845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP84_RS20850	COG0765	amino acid transport
HEP84_RS20855	COG0765	amino acid transport
HEP84_RS20860	COG1126	abc transporter atp-binding protein
HEP84_RS20875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS20890	COG1362	aminopeptidase activity
HEP84_RS20910	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS20920	COG3397	chitin binding
HEP84_RS20960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HEP84_RS21015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP84_RS21020	COG2188	Transcriptional regulator
HEP84_RS21035	COG0673	inositol 2-dehydrogenase activity
HEP84_RS21040	COG4702	Belongs to the UPF0303 family
HEP84_RS21050	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
HEP84_RS21050	COG0706	membrane insertase activity
HEP84_RS21070	COG3764	Sortase (surface protein transpeptidase)
HEP84_RS21080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEP84_RS21125	COG3250	beta-galactosidase activity
HEP84_RS21140	COG1846	Transcriptional regulator
HEP84_RS21170	COG2733	membrane
HEP84_RS21185	COG1131	(ABC) transporter
HEP84_RS21200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP84_RS21240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEP84_RS21250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HEP84_RS21255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEP84_RS21260	COG1263	PTS System
HEP84_RS21265	COG1263	PTS System
HEP84_RS21295	COG1113	amino acid transport
HEP84_RS21310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HEP84_RS21320	COG1335	isochorismatase
HEP84_RS21355	COG0277	FAD linked oxidase domain protein
HEP84_RS21365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HEP84_RS21385	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEP84_RS21390	COG4948	Mandelate Racemase Muconate Lactonizing
HEP84_RS21410	COG0531	amino acid
HEP84_RS21460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP84_RS21465	COG0395	ABC-type sugar transport system, permease component
HEP84_RS21470	COG1175	transmembrane transport
HEP84_RS21475	COG1653	transport
HEP84_RS21485	COG1678	Uncharacterized ACR, COG1678
HEP84_RS21490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP84_RS21495	COG0776	regulation of translation
HEP84_RS21505	COG3973	AAA domain
HEP84_RS21535	COG2223	nitrite transmembrane transporter activity
HEP84_RS21555	COG0583	DNA-binding transcription factor activity
HEP84_RS21570	COG1175	transmembrane transport
HEP84_RS21575	COG0395	ABC-type sugar transport system, permease component
HEP84_RS21580	COG1501	Belongs to the glycosyl hydrolase 31 family
HEP84_RS21585	COG1609	Transcriptional regulator
HEP84_RS21590	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP84_RS21615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HEP84_RS21620	COG0793	Belongs to the peptidase S41A family
HEP84_RS21630	COG2884	Cell division ATP-binding protein ftsE
HEP84_RS21645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEP84_RS21650	COG0515	serine threonine protein kinase
HEP84_RS21655	COG0515	serine threonine protein kinase
HEP84_RS21685	COG0395	ABC-type sugar transport system, permease component
HEP84_RS21690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP84_RS21690	COG0463	Glycosyl transferase, family 2
HEP84_RS21695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP84_RS21700	COG1216	Glycosyl transferase, family 2
HEP84_RS21715	COG1764	response to oxidative stress
HEP84_RS21720	COG1846	Transcriptional regulator
HEP84_RS21760	COG2197	response regulator
HEP84_RS21780	COG1134	teichoic acid transport
HEP84_RS21785	COG0438	transferase activity, transferring glycosyl groups
HEP84_RS21790	COG0463	Glycosyl transferase, family 2
HEP84_RS21790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HEP84_RS21800	COG2902	Dehydrogenase
HEP84_RS21825	COG0653	protein targeting
HEP84_RS21835	COG3214	Protein conserved in bacteria
HEP84_RS21840	COG2197	response regulator
HEP84_RS21845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEP84_RS21855	COG0823	Involved in the tonB-independent uptake of proteins
HEP84_RS21860	COG5002	protein histidine kinase activity
HEP84_RS21860	COG5000	phosphorelay sensor kinase activity
HEP84_RS21865	COG0745	RESPONSE REGULATOR receiver
HEP84_RS21870	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HEP84_RS21890	COG0714	Associated with various cellular activities
HEP84_RS21930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HEP84_RS21940	COG1482	cell wall glycoprotein biosynthetic process
HEP84_RS21950	COG2835	tetraacyldisaccharide 4'-kinase activity
HEP84_RS21955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP84_RS21960	COG1620	l-lactate permease
HEP84_RS21995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HEP84_RS22000	COG0778	Nitroreductase
HEP84_RS22000	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HEP84_RS22025	COG1316	TRANSCRIPTIONal
HEP84_RS22030	COG1316	TRANSCRIPTIONal
HEP84_RS22045	COG1316	TRANSCRIPTIONal
HEP84_RS22050	COG1316	TRANSCRIPTIONal
HEP84_RS22060	COG1011	Hydrolase
HEP84_RS22070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP84_RS22095	COG1902	pentaerythritol trinitrate reductase activity
HEP84_RS22120	COG2205	protein histidine kinase activity
HEP84_RS22125	COG0745	RESPONSE REGULATOR receiver
HEP84_RS22130	COG3104	oligopeptide transport
HEP84_RS22170	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP84_RS22175	COG1191	sigma factor activity
HEP84_RS22185	COG1228	amidohydrolase
HEP84_RS22195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP84_RS22200	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HEP84_RS22245	COG2986	histidine ammonia-lyase
HEP84_RS22255	COG1174	glycine betaine transport
HEP84_RS22260	COG1174	glycine betaine transport
HEP84_RS22270	COG1609	Transcriptional regulator
HEP84_RS22300	COG2755	lipolytic protein G-D-S-L family
HEP84_RS22305	COG0183	Belongs to the thiolase family
HEP84_RS22340	COG1136	(ABC) transporter
HEP84_RS22340	COG0577	efflux transmembrane transporter activity
HEP84_RS22345	COG0577	efflux transmembrane transporter activity
HEP84_RS22350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEP84_RS22355	COG1252	NADH dehydrogenase
HEP84_RS22375	COG0148	phosphopyruvate hydratase activity
HEP84_RS22390	COG2124	cytochrome p450
HEP84_RS22495	COG1309	transcriptional regulator
HEP84_RS22510	COG0577	efflux transmembrane transporter activity
HEP84_RS22510	COG1136	(ABC) transporter
HEP84_RS22515	COG1136	(ABC) transporter
HEP84_RS22520	COG2814	Major facilitator Superfamily
HEP84_RS22530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP84_RS22560	COG4585	Histidine kinase
HEP84_RS22575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HEP84_RS22580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP84_RS22585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HEP84_RS22590	COG0193	aminoacyl-tRNA hydrolase activity
HEP84_RS22600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HEP84_RS22610	COG1309	transcriptional regulator
HEP84_RS22620	COG4106	trans-aconitate 2-methyltransferase activity
HEP84_RS22630	COG2197	response regulator
HEP84_RS22640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HEP84_RS22670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP84_RS22690	COG0488	(ABC) transporter
HEP84_RS22700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HEP84_RS22705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HEP84_RS22715	COG0084	hydrolase, TatD family'
HEP84_RS22755	COG0768	penicillin binding
HEP84_RS22765	COG0442	prolyl-tRNA aminoacylation
HEP84_RS22795	COG0310	cobalt ion transport
HEP84_RS22805	COG1122	ATPase activity
HEP84_RS22810	COG1846	Transcriptional regulator
HEP84_RS22815	COG1764	response to oxidative stress
HEP84_RS22830	COG2409	Drug exporters of the RND superfamily
HEP84_RS22840	COG0793	Belongs to the peptidase S41A family
HEP84_RS22840	COG4946	Tricorn protease homolog
HEP84_RS22850	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS22855	COG2267	carboxylic ester hydrolase activity
HEP84_RS22860	COG2072	flavoprotein involved in K transport
HEP84_RS22870	COG0708	Exodeoxyribonuclease III
HEP84_RS22890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP84_RS22895	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEP84_RS22895	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP84_RS22900	COG0315	cyclic pyranopterin monophosphate synthase activity
HEP84_RS22910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEP84_RS22915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEP84_RS22925	COG3263	regulation of cellular component size
HEP84_RS22940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEP84_RS22950	COG1970	mechanosensitive ion channel activity
HEP84_RS22970	COG1376	ErfK ybiS ycfS ynhG family protein
HEP84_RS22985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP84_RS22985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEP84_RS22985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP84_RS22995	COG1349	DNA-binding transcription factor activity
HEP84_RS23030	COG0477	Major facilitator Superfamily
HEP84_RS23050	COG1247	-acetyltransferase
HEP84_RS23055	COG3384	dioxygenase
HEP84_RS23060	COG1846	Transcriptional regulator
HEP84_RS23080	COG1414	Transcriptional regulator
HEP84_RS23085	COG0477	Major facilitator Superfamily
HEP84_RS23145	COG1113	amino acid transport
HEP84_RS23245	COG1609	Transcriptional regulator
HEP84_RS23270	COG0028	Belongs to the TPP enzyme family
HEP84_RS23290	COG0726	polysaccharide deacetylase
HEP84_RS23310	COG1131	(ABC) transporter
HEP84_RS23315	COG1725	Transcriptional regulator
HEP84_RS23355	COG0277	FAD linked oxidase domain protein
HEP84_RS23370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP84_RS23405	COG0386	Belongs to the glutathione peroxidase family
HEP84_RS23420	COG1686	Belongs to the peptidase S11 family
HEP84_RS23475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP84_RS23490	COG4221	oxidoreductase activity
HEP84_RS23495	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS23500	COG2267	carboxylic ester hydrolase activity
HEP84_RS23520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEP84_RS23580	COG1024	Enoyl-CoA hydratase
HEP84_RS23585	COG0515	serine threonine protein kinase
HEP84_RS23585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP84_RS23595	COG1309	transcriptional regulator
HEP84_RS23605	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS23640	COG0259	pyridoxamine-phosphate oxidase activity
HEP84_RS23645	COG0583	DNA-binding transcription factor activity
HEP84_RS23695	COG1024	Enoyl-CoA hydratase
HEP84_RS23700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP84_RS23725	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS23730	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS23745	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS23750	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS23760	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS23775	COG1595	DNA-templated transcription, initiation
HEP84_RS23825	COG2267	carboxylic ester hydrolase activity
HEP84_RS23835	COG4821	SIS domain
HEP84_RS23855	COG0259	pyridoxamine-phosphate oxidase activity
HEP84_RS23865	COG1024	Enoyl-CoA hydratase
HEP84_RS23870	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS23885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP84_RS23915	COG1132	(ABC) transporter
HEP84_RS23920	COG0247	lactate metabolic process
HEP84_RS23920	COG0277	FAD linked oxidase domain protein
HEP84_RS23945	COG2124	cytochrome p450
HEP84_RS23955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEP84_RS23960	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP84_RS23985	COG0667	Aldo Keto reductase
HEP84_RS24000	COG1846	Transcriptional regulator
HEP84_RS24010	COG2252	PERMEase
HEP84_RS24020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP84_RS24035	COG3547	Transposase (IS116 IS110 IS902 family)
HEP84_RS24060	COG2814	Major facilitator Superfamily
HEP84_RS24070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEP84_RS24075	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP84_RS24080	COG1278	Cold shock
HEP84_RS24105	COG1061	Type III restriction enzyme res subunit
HEP84_RS24120	COG3973	AAA domain
HEP84_RS24125	COG3142	Participates in the control of copper homeostasis
HEP84_RS24155	COG1737	Transcriptional regulator
HEP84_RS24160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEP84_RS24165	COG1263	PTS System
HEP84_RS24165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEP84_RS24225	COG0459	protein refolding
HEP84_RS24245	COG0463	Glycosyl transferase, family 2
HEP84_RS24310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP84_RS24335	COG0308	aminopeptidase N
HEP84_RS24360	COG0456	acetyltransferase
HEP84_RS24365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP84_RS24365	COG0723	plastoquinol--plastocyanin reductase activity
HEP84_RS24425	COG3842	ATPase activity
HEP84_RS24445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEP84_RS24450	COG0215	cysteine-tRNA ligase activity
HEP84_RS24455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HEP84_RS24460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HEP84_RS24465	COG1329	Transcriptional regulator
HEP84_RS24485	COG5002	protein histidine kinase activity
HEP84_RS24555	COG0277	FAD linked oxidase domain protein
HEP84_RS24570	COG0588	phosphoglycerate mutase activity
HEP84_RS24605	COG0438	transferase activity, transferring glycosyl groups
HEP84_RS24650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP84_RS24675	COG1063	alcohol dehydrogenase
HEP84_RS24705	COG2188	Transcriptional regulator
HEP84_RS24715	COG2188	Transcriptional regulator
HEP84_RS24725	COG4552	Acetyltransferase involved in intracellular survival and related
HEP84_RS24740	COG1490	D-aminoacyl-tRNA deacylase activity
HEP84_RS24745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP84_RS24755	COG3485	protocatechuate 3,4-dioxygenase
HEP84_RS24790	COG2897	thiosulfate sulfurtransferase activity
HEP84_RS24815	COG0745	RESPONSE REGULATOR receiver
HEP84_RS24820	COG1609	Transcriptional regulator
HEP84_RS24855	COG0745	RESPONSE REGULATOR receiver
HEP84_RS24860	COG1132	(ABC) transporter
HEP84_RS24875	COG0737	Belongs to the 5'-nucleotidase family
HEP84_RS24880	COG0456	acetyltransferase
HEP84_RS24895	COG1131	(ABC) transporter
HEP84_RS24910	COG1725	Transcriptional regulator
HEP84_RS24915	COG1131	(ABC) transporter
HEP84_RS24930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HEP84_RS24960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEP84_RS24965	COG0306	phosphate transporter
HEP84_RS24975	COG1937	Protein conserved in bacteria
HEP84_RS24995	COG0277	FAD linked oxidase domain protein
HEP84_RS25000	COG0671	phosphoesterase, PA-phosphatase related
HEP84_RS25005	COG1196	nuclear chromosome segregation
HEP84_RS25005	COG0741	lytic transglycosylase activity
HEP84_RS25005	COG0739	heme binding
HEP84_RS25110	COG1252	NADH dehydrogenase
HEP84_RS25120	COG1470	cell adhesion involved in biofilm formation
HEP84_RS25120	COG0366	Alpha amylase catalytic
HEP84_RS25140	COG0579	oxidoreductase
HEP84_RS25145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HEP84_RS25155	COG0667	Aldo Keto reductase
HEP84_RS25180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP84_RS25180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEP84_RS25190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP84_RS25210	COG0513	Belongs to the DEAD box helicase family
HEP84_RS25250	COG1643	Atp-dependent helicase
HEP84_RS25285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HEP84_RS25310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP84_RS25315	COG0047	phosphoribosylformylglycinamidine synthase activity
HEP84_RS25320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEP84_RS25355	COG2197	response regulator
HEP84_RS25365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HEP84_RS25380	COG0151	Belongs to the GarS family
HEP84_RS25465	COG0433	COG0433 Predicted ATPase
HEP84_RS25480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HEP84_RS25515	COG1191	sigma factor activity
HEP84_RS25520	COG1191	sigma factor activity
HEP84_RS25540	COG0477	Major facilitator Superfamily
HEP84_RS25550	COG3467	pyridoxamine 5'-phosphate
HEP84_RS25560	COG0477	Major facilitator Superfamily
HEP84_RS25565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP84_RS25575	COG2205	protein histidine kinase activity
HEP84_RS25580	COG0745	RESPONSE REGULATOR receiver
HEP84_RS25590	COG2329	Antibiotic biosynthesis monooxygenase
HEP84_RS25605	COG1846	Transcriptional regulator
HEP84_RS25890	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS25895	COG1595	DNA-templated transcription, initiation
HEP84_RS25920	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS25970	COG0494	nUDIX hydrolase
HEP84_RS25995	COG2188	Transcriptional regulator
HEP84_RS26055	COG0653	protein targeting
HEP84_RS26075	COG0006	proline dipeptidase activity
HEP84_RS26115	COG4585	Histidine kinase
HEP84_RS26150	COG2837	iron assimilation
HEP84_RS26160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HEP84_RS26165	COG0561	phosphatase activity
HEP84_RS26195	COG1131	(ABC) transporter
HEP84_RS26210	COG0789	Transcriptional regulator
HEP84_RS26215	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HEP84_RS26225	COG0561	phosphatase activity
HEP84_RS26240	COG1294	oxidase, subunit
HEP84_RS26245	COG1271	oxidase subunit
HEP84_RS26250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP84_RS26255	COG1609	Transcriptional regulator
HEP84_RS26275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HEP84_RS26300	COG0662	Cupin 2, conserved barrel domain protein
HEP84_RS26305	COG1950	PFAM Membrane protein of
HEP84_RS26310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP84_RS26315	COG0626	cystathionine gamma-synthase activity
HEP84_RS26350	COG2814	Major facilitator Superfamily
HEP84_RS26370	COG0305	Participates in initiation and elongation during chromosome replication
HEP84_RS26380	COG0359	binds to the 23S rRNA
HEP84_RS26385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP84_RS26390	COG0629	single-stranded DNA binding
HEP84_RS26395	COG0360	Binds together with S18 to 16S ribosomal RNA
HEP84_RS26430	COG1260	myo-inositol-1-phosphate synthase
HEP84_RS26445	COG0617	tRNA 3'-terminal CCA addition
HEP84_RS26465	COG1595	DNA-templated transcription, initiation
HEP84_RS26475	COG0492	ferredoxin-NADP+ reductase activity
HEP84_RS26480	COG3118	belongs to the thioredoxin family
HEP84_RS26495	COG1192	Involved in chromosome partitioning
HEP84_RS26500	COG0357	Ribosomal RNA small subunit methyltransferase G
HEP84_RS26510	COG0706	membrane insertase activity
HEP84_RS26515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HEP84_RS26520	COG0594	ribonuclease P activity
HEP84_RS26525	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEP84_RS26535	COG0592	DNA-directed DNA polymerase activity
HEP84_RS26540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP84_RS26545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HEP84_RS26550	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HEP84_RS26555	COG0187	DNA topoisomerase II activity
HEP84_RS26560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP84_RS26590	COG0515	serine threonine protein kinase
HEP84_RS26615	COG0705	Rhomboid family
HEP84_RS26630	COG3764	Sortase (surface protein transpeptidase)
HEP84_RS26650	COG3764	Sortase (surface protein transpeptidase)
HEP84_RS26660	COG0515	serine threonine protein kinase
HEP84_RS26665	COG0768	penicillin binding
HEP84_RS26680	COG1716	ATPase activity
HEP84_RS26715	COG0745	RESPONSE REGULATOR receiver
HEP84_RS26725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP84_RS26730	COG4770	biotin carboxylase activity
HEP84_RS26745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEP84_RS26765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP84_RS26790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP84_RS26820	COG0475	glutathione-regulated potassium exporter activity
HEP84_RS26830	COG1733	regulation of RNA biosynthetic process
HEP84_RS26835	COG0477	Major facilitator Superfamily
HEP84_RS26855	COG0277	FAD linked oxidase domain protein
HEP84_RS26875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HEP84_RS26880	COG1733	regulation of RNA biosynthetic process
HEP84_RS26925	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS26930	COG1309	transcriptional regulator
HEP84_RS26935	COG1522	sequence-specific DNA binding
HEP84_RS26955	COG0746	molybdenum cofactor guanylyltransferase activity
HEP84_RS26980	COG3321	synthase
HEP84_RS26980	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS26980	COG0604	alcohol dehydrogenase
HEP84_RS26995	COG0515	serine threonine protein kinase
HEP84_RS27000	COG0515	serine threonine protein kinase
HEP84_RS27025	COG0022	dehydrogenase e1 component
HEP84_RS27030	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP84_RS27040	COG1802	Transcriptional regulator
HEP84_RS27090	COG1362	aminopeptidase activity
HEP84_RS27095	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS27105	COG1741	Belongs to the pirin family
HEP84_RS27120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEP84_RS27150	COG3866	Pectate lyase
HEP84_RS27160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEP84_RS27175	COG0583	DNA-binding transcription factor activity
HEP84_RS27185	COG1289	transmembrane transporter activity
HEP84_RS27195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP84_RS27200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP84_RS27235	COG0745	RESPONSE REGULATOR receiver
HEP84_RS27260	COG1473	amidohydrolase
HEP84_RS27280	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HEP84_RS27290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP84_RS27320	COG0222	ribosome binding
HEP84_RS27330	COG1278	Cold shock
HEP84_RS27370	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEP84_RS27420	COG2815	serine threonine protein kinase
HEP84_RS27420	COG0515	serine threonine protein kinase
HEP84_RS27455	COG0561	phosphatase activity
HEP84_RS27495	COG0745	RESPONSE REGULATOR receiver
HEP84_RS27500	COG5002	protein histidine kinase activity
HEP84_RS27505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEP84_RS27545	COG0640	Transcriptional regulator
HEP84_RS27550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP84_RS27565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP84_RS27655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP84_RS27665	COG2326	polyphosphate kinase activity
HEP84_RS27670	COG3387	PFAM Glycoside hydrolase 15-related
HEP84_RS27675	COG0477	Major facilitator Superfamily
HEP84_RS27680	COG0596	Alpha beta hydrolase
HEP84_RS27680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP84_RS27725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEP84_RS27780	COG2205	protein histidine kinase activity
HEP84_RS27785	COG0745	RESPONSE REGULATOR receiver
HEP84_RS27845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP84_RS27875	COG0717	Belongs to the dCTP deaminase family
HEP84_RS27930	COG0247	lactate metabolic process
HEP84_RS27930	COG2181	nitrate reductase activity
HEP84_RS27935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP84_RS27940	COG0443	Heat shock 70 kDa protein
HEP84_RS27945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP84_RS27950	COG0484	heat shock protein binding
HEP84_RS27955	COG0789	Transcriptional regulator
HEP84_RS27970	COG4213	ABC transporter substrate-binding protein
HEP84_RS27995	COG1305	Transglutaminase-like
HEP84_RS28035	COG0542	response to heat
HEP84_RS28065	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HEP84_RS28080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HEP84_RS28085	COG0191	fructose-bisphosphate aldolase activity
HEP84_RS28105	COG3844	kynureninase activity
HEP84_RS28135	COG2197	response regulator
HEP84_RS28140	COG4585	Histidine kinase
HEP84_RS28145	COG2197	response regulator
HEP84_RS28155	COG3559	Exporter of polyketide antibiotics
HEP84_RS28160	COG1131	(ABC) transporter
HEP84_RS28175	COG4303	Ethanolamine ammonia lyase large subunit
HEP84_RS28190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HEP84_RS28200	COG1278	Cold shock
HEP84_RS28205	COG0737	Belongs to the 5'-nucleotidase family
HEP84_RS28215	COG1802	Transcriptional regulator
HEP84_RS28225	COG0693	protein deglycase activity
HEP84_RS28250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEP84_RS28255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HEP84_RS28290	COG5000	phosphorelay sensor kinase activity
HEP84_RS28290	COG5002	protein histidine kinase activity
HEP84_RS28370	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP84_RS28370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP84_RS28375	COG3903	Transcriptional regulator
HEP84_RS28375	COG3629	intracellular signal transduction
HEP84_RS28380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS28385	COG3251	PFAM MbtH domain protein
HEP84_RS28390	COG2175	clavaminate synthase activity
HEP84_RS28395	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS28400	COG5285	phytanoyl-CoA dioxygenase
HEP84_RS28460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HEP84_RS28465	COG0330	HflC and HflK could
HEP84_RS28530	COG1408	metallophosphoesterase
HEP84_RS28550	COG0003	Pfam Anion-transporting ATPase
HEP84_RS28575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP84_RS28605	COG0596	Alpha beta hydrolase
HEP84_RS28615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HEP84_RS28620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP84_RS28625	COG0659	secondary active sulfate transmembrane transporter activity
HEP84_RS28685	COG1111	helicase
HEP84_RS28685	COG1205	dead DEAH box helicase
HEP84_RS28690	COG1366	Belongs to the anti-sigma-factor antagonist family
HEP84_RS28695	COG2172	sigma factor antagonist activity
HEP84_RS28700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HEP84_RS28725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEP84_RS28725	COG1754	DNA topoisomerase type I activity
HEP84_RS28730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HEP84_RS28735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HEP84_RS28780	COG3629	intracellular signal transduction
HEP84_RS28780	COG3903	Transcriptional regulator
HEP84_RS28785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP84_RS28785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HEP84_RS28810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEP84_RS28815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEP84_RS28820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP84_RS28825	COG0254	rRNA binding
HEP84_RS28835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP84_RS28855	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS28860	COG2318	DinB family
HEP84_RS28870	COG0076	glutamate decarboxylase activity
HEP84_RS28880	COG0789	Transcriptional regulator
HEP84_RS28885	COG0393	Putative heavy-metal-binding
HEP84_RS28890	COG0586	Pfam SNARE associated Golgi protein
HEP84_RS28900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEP84_RS28905	COG2027	D-alanyl-D-alanine carboxypeptidase
HEP84_RS28915	COG0037	tRNA processing
HEP84_RS28930	COG0302	gtp cyclohydrolase
HEP84_RS28945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEP84_RS28960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HEP84_RS28960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HEP84_RS28985	COG0649	NAD binding
HEP84_RS29000	COG2197	response regulator
HEP84_RS29005	COG1660	Displays ATPase and GTPase activities
HEP84_RS29030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HEP84_RS29035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEP84_RS29045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HEP84_RS29065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEP84_RS29100	COG0739	heme binding
HEP84_RS29115	COG2205	protein histidine kinase activity
HEP84_RS29125	COG0745	RESPONSE REGULATOR receiver
HEP84_RS29135	COG1595	DNA-templated transcription, initiation
HEP84_RS29150	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HEP84_RS29170	COG0248	Ppx GppA phosphatase
HEP84_RS29175	COG1082	Xylose isomerase domain protein TIM barrel
HEP84_RS29180	COG1309	transcriptional regulator
HEP84_RS29185	COG0129	dihydroxy-acid dehydratase activity
HEP84_RS29190	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEP84_RS29190	COG0515	serine threonine protein kinase
HEP84_RS29195	COG4991	sh3 domain protein
HEP84_RS29215	COG0842	Transport permease protein
HEP84_RS29215	COG1129	ABC transporter
HEP84_RS29225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEP84_RS29230	COG0180	Tryptophanyl-tRNA synthetase
HEP84_RS29265	COG0123	including yeast histone deacetylase and acetoin utilization protein
HEP84_RS29315	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HEP84_RS29320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HEP84_RS29325	COG0181	hydroxymethylbilane synthase activity
HEP84_RS29330	COG1648	precorrin-2 dehydrogenase activity
HEP84_RS29330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HEP84_RS29335	COG0113	porphobilinogen synthase activity
HEP84_RS29355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP84_RS29370	COG0018	arginyl-trna synthetase
HEP84_RS29375	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HEP84_RS29395	COG1690	Belongs to the RtcB family
HEP84_RS29415	COG1742	UPF0060 membrane protein
HEP84_RS29425	COG1846	Transcriptional regulator
HEP84_RS29435	COG0477	Major facilitator Superfamily
HEP84_RS29445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS29475	COG0531	amino acid
HEP84_RS29480	COG2197	response regulator
HEP84_RS29490	COG1136	(ABC) transporter
HEP84_RS29495	COG1136	(ABC) transporter
HEP84_RS29495	COG0577	efflux transmembrane transporter activity
HEP84_RS29515	COG0501	Belongs to the peptidase M48B family
HEP84_RS29525	COG1968	undecaprenyl-diphosphatase activity
HEP84_RS29550	COG0531	amino acid
HEP84_RS29560	COG0598	Magnesium transport protein CorA
HEP84_RS29565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP84_RS29570	COG0489	protein tyrosine kinase activity
HEP84_RS29590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEP84_RS29610	COG1064	alcohol dehydrogenase
HEP84_RS29625	COG0367	asparagine synthase
HEP84_RS29630	COG0438	transferase activity, transferring glycosyl groups
HEP84_RS29635	COG2226	methyltransferase
HEP84_RS29640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEP84_RS29645	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HEP84_RS29650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEP84_RS29660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP84_RS29665	COG0406	alpha-ribazole phosphatase activity
HEP84_RS29685	COG1333	cytochrome c biogenesis protein
HEP84_RS29690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HEP84_RS29735	COG3321	synthase
HEP84_RS29735	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS29735	COG0604	alcohol dehydrogenase
HEP84_RS29740	COG0640	Transcriptional regulator
HEP84_RS29760	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEP84_RS29765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HEP84_RS29770	COG0163	prenyltransferase activity
HEP84_RS29780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP84_RS29810	COG0183	Belongs to the thiolase family
HEP84_RS29825	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HEP84_RS29840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HEP84_RS29870	COG2226	methyltransferase
HEP84_RS29900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP84_RS29905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP84_RS29910	COG0649	NAD binding
HEP84_RS29920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP84_RS29925	COG1034	ATP synthesis coupled electron transport
HEP84_RS29930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP84_RS29935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP84_RS29945	COG0713	ATP synthesis coupled electron transport
HEP84_RS29950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP84_RS29960	COG1007	ATP synthesis coupled electron transport
HEP84_RS29970	COG0514	ATP-dependent DNA helicase (RecQ)
HEP84_RS29990	COG2188	Transcriptional regulator
HEP84_RS30005	COG0492	ferredoxin-NADP+ reductase activity
HEP84_RS30015	COG5280	Phage tail tape measure protein TP901
HEP84_RS30015	COG3953	SLT domain
HEP84_RS30050	COG1131	(ABC) transporter
HEP84_RS30090	COG0702	epimerase
HEP84_RS30095	COG1733	regulation of RNA biosynthetic process
HEP84_RS30100	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEP84_RS30105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEP84_RS30105	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEP84_RS30125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP84_RS30130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP84_RS30135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEP84_RS30140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HEP84_RS30155	COG0713	ATP synthesis coupled electron transport
HEP84_RS30160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEP84_RS30170	COG1007	ATP synthesis coupled electron transport
HEP84_RS30175	COG0501	Belongs to the peptidase M48B family
HEP84_RS30180	COG3304	Inner membrane component domain
HEP84_RS30200	COG2261	transglycosylase associated protein
HEP84_RS30205	COG1666	GTP binding
HEP84_RS30240	COG0702	epimerase
HEP84_RS30260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP84_RS30265	COG2030	dehydratase
HEP84_RS30280	COG0477	Major facilitator Superfamily
HEP84_RS30285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEP84_RS30290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP84_RS30305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP84_RS30310	COG0436	Aminotransferase
HEP84_RS30330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HEP84_RS30335	COG0081	regulation of translation
HEP84_RS30350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HEP84_RS30355	COG0222	ribosome binding
HEP84_RS30365	COG0085	RNA polymerase activity
HEP84_RS30370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HEP84_RS30400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP84_RS30405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HEP84_RS30410	COG0049	tRNA binding
HEP84_RS30415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HEP84_RS30420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HEP84_RS30435	COG2124	cytochrome p450
HEP84_RS30460	COG1404	Belongs to the peptidase S8 family
HEP84_RS30500	COG0051	transcription antitermination factor activity, RNA binding
HEP84_RS30505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HEP84_RS30510	COG0088	Forms part of the polypeptide exit tunnel
HEP84_RS30515	COG0089	rRNA binding
HEP84_RS30520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP84_RS30525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEP84_RS30530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HEP84_RS30535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HEP84_RS30540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEP84_RS30545	COG0255	Belongs to the universal ribosomal protein uL29 family
HEP84_RS30550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HEP84_RS30555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HEP84_RS30560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HEP84_RS30565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP84_RS30570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEP84_RS30580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HEP84_RS30585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HEP84_RS30590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HEP84_RS30595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEP84_RS30600	COG1841	ribosomal large subunit assembly
HEP84_RS30605	COG0200	Binds to the 23S rRNA
HEP84_RS30615	COG0563	adenylate kinase activity
HEP84_RS30625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HEP84_RS30630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEP84_RS30635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEP84_RS30640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEP84_RS30645	COG0202	RNA polymerase activity
HEP84_RS30650	COG0203	ribosomal protein L17
HEP84_RS30655	COG0101	tRNA pseudouridine synthase activity
HEP84_RS30665	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HEP84_RS30665	COG4124	Belongs to the glycosyl hydrolase 26 family
HEP84_RS30680	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP84_RS30685	COG0463	Glycosyl transferase, family 2
HEP84_RS30695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HEP84_RS30700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HEP84_RS30705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP84_RS30715	COG1072	(Pantothenic acid kinase))
HEP84_RS30720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP84_RS30770	COG0736	holo-[acyl-carrier-protein] synthase activity
HEP84_RS30785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HEP84_RS30795	COG0802	atpase or kinase
HEP84_RS30820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HEP84_RS30840	COG1175	transmembrane transport
HEP84_RS30845	COG0395	ABC-type sugar transport system, permease component
HEP84_RS30850	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP84_RS30855	COG1609	Transcriptional regulator
HEP84_RS30890	COG4941	Belongs to the sigma-70 factor family
HEP84_RS30900	COG0726	polysaccharide deacetylase
HEP84_RS30905	COG0726	polysaccharide deacetylase
HEP84_RS30910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HEP84_RS30915	COG0459	protein refolding
HEP84_RS30925	COG4221	oxidoreductase activity
HEP84_RS30935	COG0583	DNA-binding transcription factor activity
HEP84_RS30950	COG1595	DNA-templated transcription, initiation
HEP84_RS30960	COG0516	GMP reductase activity
HEP84_RS30975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEP84_RS30995	COG0515	serine threonine protein kinase
HEP84_RS31000	COG2815	serine threonine protein kinase
HEP84_RS31000	COG0515	serine threonine protein kinase
HEP84_RS31005	COG0515	serine threonine protein kinase
HEP84_RS31020	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS31090	COG2197	response regulator
HEP84_RS31125	COG0739	heme binding
HEP84_RS31135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS31135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS31155	COG0714	Associated with various cellular activities
HEP84_RS31165	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP84_RS31180	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP84_RS31210	COG0138	bifunctional purine biosynthesis protein purh
HEP84_RS31230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP84_RS31250	COG0039	L-malate dehydrogenase activity
HEP84_RS31270	COG1846	Transcriptional regulator
HEP84_RS31270	COG0456	acetyltransferase
HEP84_RS31275	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS31285	COG0517	IMP dehydrogenase activity
HEP84_RS31285	COG4175	Glycine betaine
HEP84_RS31305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS31310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS31320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS31330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP84_RS31340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP84_RS31345	COG0512	Glutamine amidotransferase of anthranilate synthase
HEP84_RS31345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEP84_RS31350	COG3224	Antibiotic biosynthesis monooxygenase
HEP84_RS31375	COG0754	glutathionylspermidine amidase activity
HEP84_RS31380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HEP84_RS31385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP84_RS31395	COG0180	Tryptophanyl-tRNA synthetase
HEP84_RS31430	COG1295	ribonuclease BN
HEP84_RS31445	COG1408	metallophosphoesterase
HEP84_RS31450	COG4166	transmembrane transport
HEP84_RS31470	COG0745	RESPONSE REGULATOR receiver
HEP84_RS31475	COG2409	Drug exporters of the RND superfamily
HEP84_RS31530	COG1053	succinate dehydrogenase
HEP84_RS31540	COG2009	succinate dehydrogenase
HEP84_RS31550	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HEP84_RS31590	COG1595	DNA-templated transcription, initiation
HEP84_RS31600	COG1595	DNA-templated transcription, initiation
HEP84_RS31615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS31615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS31635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP84_RS31645	COG1216	Glycosyl transferase, family 2
HEP84_RS31660	COG2089	acid synthase
HEP84_RS31680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HEP84_RS31685	COG4195	phage-related replication protein
HEP84_RS31735	COG1473	amidohydrolase
HEP84_RS31735	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HEP84_RS31740	COG1744	ABC transporter substrate-binding protein PnrA-like
HEP84_RS31745	COG1744	ABC transporter substrate-binding protein PnrA-like
HEP84_RS31795	COG0592	DNA-directed DNA polymerase activity
HEP84_RS31800	COG2814	Major facilitator Superfamily
HEP84_RS31805	COG0583	DNA-binding transcription factor activity
HEP84_RS31815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP84_RS31840	COG2205	protein histidine kinase activity
HEP84_RS31845	COG0745	RESPONSE REGULATOR receiver
HEP84_RS31850	COG1595	DNA-templated transcription, initiation
HEP84_RS31865	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS31870	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS31875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HEP84_RS31890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEP84_RS31920	COG4770	biotin carboxylase activity
HEP84_RS31930	COG0424	maF-like protein
HEP84_RS31945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP84_RS31955	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP84_RS31965	COG1024	Enoyl-CoA hydratase
HEP84_RS31975	COG2986	histidine ammonia-lyase
HEP84_RS31980	COG1278	Cold shock
HEP84_RS32015	COG1136	(ABC) transporter
HEP84_RS32020	COG1404	Belongs to the peptidase S8 family
HEP84_RS32035	COG1064	alcohol dehydrogenase
HEP84_RS32040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP84_RS32045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEP84_RS32055	COG2132	Multicopper oxidase
HEP84_RS32090	COG0640	Transcriptional regulator
HEP84_RS32095	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS32160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP84_RS32185	COG2255	four-way junction helicase activity
HEP84_RS32190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEP84_RS32230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEP84_RS32235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP84_RS32245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP84_RS32275	COG1331	Highly conserved protein containing a thioredoxin domain
HEP84_RS32305	COG1309	transcriptional regulator
HEP84_RS32310	COG0477	Major facilitator Superfamily
HEP84_RS32320	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HEP84_RS32400	COG0436	Aminotransferase
HEP84_RS32415	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HEP84_RS32430	COG1414	Transcriptional regulator
HEP84_RS32435	COG0251	oxidation-reduction process
HEP84_RS32440	COG2610	gluconate transmembrane transporter activity
HEP84_RS32500	COG4257	antibiotic catabolic process
HEP84_RS32535	COG2894	cell division
HEP84_RS32565	COG2197	response regulator
HEP84_RS32585	COG2885	chlorophyll binding
HEP84_RS32590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP84_RS32620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HEP84_RS32625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HEP84_RS32640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS32645	COG0450	alkyl hydroperoxide reductase
HEP84_RS32660	COG1136	(ABC) transporter
HEP84_RS32675	COG4499	WXG100 protein secretion system (Wss), protein YukC
HEP84_RS32675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEP84_RS32695	COG0114	fumarate hydratase activity
HEP84_RS32710	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP84_RS32710	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEP84_RS32735	COG0778	Nitroreductase
HEP84_RS32740	COG1722	exodeoxyribonuclease VII activity
HEP84_RS32745	COG1570	exodeoxyribonuclease VII activity
HEP84_RS32750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HEP84_RS32765	COG0012	GTP binding
HEP84_RS32775	COG1674	ftsk spoiiie
HEP84_RS32900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEP84_RS32905	COG1053	succinate dehydrogenase
HEP84_RS32940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP84_RS32945	COG0444	Belongs to the ABC transporter superfamily
HEP84_RS32950	COG4608	Belongs to the ABC transporter superfamily
HEP84_RS32955	COG0346	lactoylglutathione lyase activity
HEP84_RS32960	COG4166	transmembrane transport
HEP84_RS32965	COG0601	transmembrane transport
HEP84_RS32970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP84_RS32975	COG0444	Belongs to the ABC transporter superfamily
HEP84_RS32980	COG4608	Belongs to the ABC transporter superfamily
HEP84_RS32995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP84_RS33015	COG1131	(ABC) transporter
HEP84_RS33025	COG4585	Histidine kinase
HEP84_RS33030	COG2197	response regulator
HEP84_RS33065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP84_RS33075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEP84_RS33085	COG0519	Catalyzes the synthesis of GMP from XMP
HEP84_RS33090	COG1024	Enoyl-CoA hydratase
HEP84_RS33105	COG1595	DNA-templated transcription, initiation
HEP84_RS33115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP84_RS33120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP84_RS33145	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HEP84_RS33155	COG0598	Magnesium transport protein CorA
HEP84_RS33165	COG2814	Major facilitator Superfamily
HEP84_RS33180	COG2095	MarC family integral membrane protein
HEP84_RS33190	COG1432	Conserved Protein
HEP84_RS33195	COG0596	Alpha beta hydrolase
HEP84_RS33240	COG0747	negative chemotaxis
HEP84_RS33250	COG0601	transmembrane transport
HEP84_RS33310	COG0210	DNA helicase
HEP84_RS33315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP84_RS33355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP84_RS33410	COG3480	Lon protease (S16) C-terminal proteolytic domain
HEP84_RS33420	COG1615	UPF0182 protein
HEP84_RS33445	COG0753	catalase activity
HEP84_RS33450	COG0517	IMP dehydrogenase activity
HEP84_RS33450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HEP84_RS33455	COG0483	inositol monophosphate 1-phosphatase activity
HEP84_RS33475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HEP84_RS33485	COG2135	peptidase activity
HEP84_RS33495	COG1595	DNA-templated transcription, initiation
HEP84_RS33500	COG5662	AntiSigma factor
HEP84_RS33520	COG0242	peptide deformylase activity
HEP84_RS33530	COG2124	cytochrome p450
HEP84_RS33550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP84_RS33575	COG2188	Transcriptional regulator
HEP84_RS33580	COG2182	Extracellular solute-binding protein
HEP84_RS33585	COG1175	transmembrane transport
HEP84_RS33590	COG0395	ABC-type sugar transport system, permease component
HEP84_RS33595	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP84_RS33600	COG0363	glucosamine-6-phosphate deaminase activity
HEP84_RS33605	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP84_RS33605	COG1672	PFAM Archaeal ATPase
HEP84_RS33610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HEP84_RS33625	COG1597	lipid kinase activity
HEP84_RS33670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP84_RS33720	COG0604	alcohol dehydrogenase
HEP84_RS33720	COG3321	synthase
HEP84_RS33720	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS33730	COG0681	Belongs to the peptidase S26 family
HEP84_RS33740	COG4106	trans-aconitate 2-methyltransferase activity
HEP84_RS33745	COG1126	abc transporter atp-binding protein
HEP84_RS33760	COG0281	malic enzyme
HEP84_RS33765	COG0604	alcohol dehydrogenase
HEP84_RS33800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP84_RS33800	COG0567	Dehydrogenase, E1 component
HEP84_RS33805	COG2205	protein histidine kinase activity
HEP84_RS33810	COG0745	RESPONSE REGULATOR receiver
HEP84_RS33815	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP84_RS33840	COG3119	arylsulfatase activity
HEP84_RS33845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEP84_RS33930	COG0701	Predicted permease
HEP84_RS33935	COG0768	penicillin binding
HEP84_RS33940	COG0772	Belongs to the SEDS family
HEP84_RS33970	COG1793	dna ligase
HEP84_RS33970	COG3285	dna ligase
HEP84_RS33975	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEP84_RS33985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEP84_RS34130	COG2188	Transcriptional regulator
HEP84_RS34195	COG0018	arginyl-trna synthetase
HEP84_RS34200	COG0019	diaminopimelate decarboxylase activity
HEP84_RS34205	COG0460	homoserine dehydrogenase
HEP84_RS34210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEP84_RS34215	COG0083	homoserine kinase activity
HEP84_RS34230	COG1316	TRANSCRIPTIONal
HEP84_RS34235	COG0254	rRNA binding
HEP84_RS34240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HEP84_RS34245	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP84_RS34255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HEP84_RS34260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP84_RS34265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEP84_RS34280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP84_RS34285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEP84_RS34290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HEP84_RS34295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HEP84_RS34300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HEP84_RS34305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEP84_RS34310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEP84_RS34325	COG2197	response regulator
HEP84_RS34330	COG4585	Histidine kinase
HEP84_RS34360	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS34375	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HEP84_RS34420	COG1131	(ABC) transporter
HEP84_RS34440	COG0183	Belongs to the thiolase family
HEP84_RS34475	COG2814	Major facilitator Superfamily
HEP84_RS34520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS34520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS34560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HEP84_RS34565	COG0857	belongs to the CobB CobQ family
HEP84_RS34565	COG0280	phosphate acetyltransferase
HEP84_RS34570	COG0205	6-phosphofructokinase activity
HEP84_RS34580	COG0395	ABC-type sugar transport system, permease component
HEP84_RS34585	COG1175	transmembrane transport
HEP84_RS34605	COG4565	transcriptional regulatory protein
HEP84_RS34610	COG3290	protein histidine kinase activity
HEP84_RS34620	COG1301	dicarboxylic acid transport
HEP84_RS34630	COG0477	Major facilitator Superfamily
HEP84_RS34640	COG0667	Aldo Keto reductase
HEP84_RS34650	COG1522	sequence-specific DNA binding
HEP84_RS34670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HEP84_RS34675	COG3281	Trehalose synthase
HEP84_RS34685	COG0366	Alpha amylase catalytic
HEP84_RS34695	COG0058	SHG alpha-glucan phosphorylase activity
HEP84_RS34715	COG1132	(ABC) transporter
HEP84_RS34720	COG1132	(ABC) transporter
HEP84_RS34725	COG1132	(ABC) transporter
HEP84_RS34730	COG1132	(ABC) transporter
HEP84_RS34735	COG1131	(ABC) transporter
HEP84_RS34745	COG4585	Histidine kinase
HEP84_RS34750	COG2197	response regulator
HEP84_RS34760	COG1376	ErfK ybiS ycfS ynhG family protein
HEP84_RS34765	COG1376	ErfK ybiS ycfS ynhG family protein
HEP84_RS34815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEP84_RS34845	COG1760	l-serine dehydratase
HEP84_RS34850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEP84_RS34855	COG0509	glycine decarboxylation via glycine cleavage system
HEP84_RS34860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEP84_RS34895	COG0444	Belongs to the ABC transporter superfamily
HEP84_RS34900	COG4608	Belongs to the ABC transporter superfamily
HEP84_RS34915	COG2860	membrane
HEP84_RS34935	COG2378	regulation of single-species biofilm formation
HEP84_RS34975	COG0482	sulfurtransferase activity
HEP84_RS34985	COG1611	Belongs to the LOG family
HEP84_RS34990	COG4221	oxidoreductase activity
HEP84_RS35000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HEP84_RS35010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP84_RS35015	COG0154	amidase activity
HEP84_RS35025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HEP84_RS35030	COG2409	Drug exporters of the RND superfamily
HEP84_RS35035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP84_RS35055	COG2133	pyrroloquinoline quinone binding
HEP84_RS35060	COG0667	Aldo Keto reductase
HEP84_RS35085	COG0440	acetolactate synthase activity
HEP84_RS35090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HEP84_RS35100	COG1672	PFAM Archaeal ATPase
HEP84_RS35100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HEP84_RS35105	COG0477	Major facilitator Superfamily
HEP84_RS35115	COG3214	Protein conserved in bacteria
HEP84_RS35125	COG0506	proline dehydrogenase activity
HEP84_RS35130	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS35145	COG1082	Xylose isomerase domain protein TIM barrel
HEP84_RS35155	COG0477	Major facilitator Superfamily
HEP84_RS35165	COG0473	3-isopropylmalate dehydrogenase activity
HEP84_RS35170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEP84_RS35190	COG0832	Belongs to the urease beta subunit family
HEP84_RS35190	COG0831	urea catabolic process
HEP84_RS35195	COG0804	urea catabolic process
HEP84_RS35200	COG2957	Belongs to the agmatine deiminase family
HEP84_RS35215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HEP84_RS35245	COG2197	response regulator
HEP84_RS35255	COG1131	(ABC) transporter
HEP84_RS35290	COG4585	Histidine kinase
HEP84_RS35295	COG2197	response regulator
HEP84_RS35300	COG2353	YceI-like domain
HEP84_RS35305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HEP84_RS35325	COG2018	Roadblock/LC7 domain
HEP84_RS35345	COG2018	Roadblock/LC7 domain
HEP84_RS35360	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP84_RS35365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HEP84_RS35410	COG1414	Transcriptional regulator
HEP84_RS35415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HEP84_RS35420	COG0066	3-isopropylmalate dehydratase activity
HEP84_RS35430	COG0776	regulation of translation
HEP84_RS35440	COG1920	GTP binding
HEP84_RS35450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HEP84_RS35455	COG1181	Belongs to the D-alanine--D-alanine ligase family
HEP84_RS35480	COG3629	intracellular signal transduction
HEP84_RS35480	COG3903	Transcriptional regulator
HEP84_RS35485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEP84_RS35490	COG1461	Dihydroxyacetone kinase
HEP84_RS35500	COG0326	Molecular chaperone. Has ATPase activity
HEP84_RS35505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEP84_RS35510	COG0742	ribosomal rna small subunit methyltransferase
HEP84_RS35515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEP84_RS35530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HEP84_RS35535	COG0571	ribonuclease III activity
HEP84_RS35540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP84_RS35545	COG1733	regulation of RNA biosynthetic process
HEP84_RS35555	COG2340	Cysteine-rich secretory protein family
HEP84_RS35560	COG1254	Belongs to the acylphosphatase family
HEP84_RS35575	COG0477	Major facilitator Superfamily
HEP84_RS35615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HEP84_RS35625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HEP84_RS35635	COG0442	prolyl-tRNA aminoacylation
HEP84_RS35645	COG0228	four-way junction DNA binding
HEP84_RS35650	COG1837	Belongs to the UPF0109 family
HEP84_RS35655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HEP84_RS35660	COG0336	Belongs to the RNA methyltransferase TrmD family
HEP84_RS35665	COG0335	large ribosomal subunit rRNA binding
HEP84_RS35675	COG0681	Belongs to the peptidase S26 family
HEP84_RS35685	COG0681	Belongs to the peptidase S26 family
HEP84_RS35690	COG1051	belongs to the nudix hydrolase family
HEP84_RS35700	COG0792	nuclease activity
HEP84_RS35720	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HEP84_RS35745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS35750	COG0500	methyltransferase
HEP84_RS35835	COG0791	NLP P60 protein
HEP84_RS35835	COG3883	PFAM NLP P60 protein
HEP84_RS35940	COG1074	ATP-dependent DNA helicase activity
HEP84_RS36055	COG1191	sigma factor activity
HEP84_RS36070	COG0052	Belongs to the universal ribosomal protein uS2 family
HEP84_RS36075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEP84_RS36080	COG0528	UMP kinase activity
HEP84_RS36085	COG0233	cytoplasmic translational termination
HEP84_RS36090	COG0575	Belongs to the CDS family
HEP84_RS36110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEP84_RS36120	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEP84_RS36160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEP84_RS36170	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS36240	COG1522	sequence-specific DNA binding
HEP84_RS36245	COG0477	Major facilitator Superfamily
HEP84_RS36250	COG2226	methyltransferase
HEP84_RS36270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HEP84_RS36285	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS36295	COG3842	ATPase activity
HEP84_RS36300	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP84_RS36305	COG1177	transmembrane transport
HEP84_RS36310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEP84_RS36340	COG2508	Transcriptional regulator
HEP84_RS36340	COG2508	Transcriptional regulator
HEP84_RS36345	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS36355	COG1472	Belongs to the glycosyl hydrolase 3 family
HEP84_RS36360	COG1653	transport
HEP84_RS36365	COG4209	transmembrane transport
HEP84_RS36370	COG0395	ABC-type sugar transport system, permease component
HEP84_RS36410	COG5297	Belongs to the glycosyl hydrolase family 6
HEP84_RS36425	COG0653	protein targeting
HEP84_RS36435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEP84_RS36440	COG0750	zinc metalloprotease
HEP84_RS36445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP84_RS36460	COG0442	prolyl-tRNA aminoacylation
HEP84_RS36505	COG0779	Required for maturation of 30S ribosomal subunits
HEP84_RS36530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HEP84_RS36535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HEP84_RS36560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEP84_RS36565	COG0601	transmembrane transport
HEP84_RS36570	COG0747	negative chemotaxis
HEP84_RS36600	COG1404	Belongs to the peptidase S8 family
HEP84_RS36675	COG1674	ftsk spoiiie
HEP84_RS36690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEP84_RS36695	COG1185	polyribonucleotide nucleotidyltransferase activity
HEP84_RS36700	COG0612	Peptidase, M16
HEP84_RS36705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HEP84_RS36725	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HEP84_RS36730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP84_RS36735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HEP84_RS36765	COG2770	Histidine kinase
HEP84_RS36765	COG2208	phosphoserine phosphatase activity
HEP84_RS36785	COG1674	ftsk spoiiie
HEP84_RS36795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP84_RS36805	COG1058	Belongs to the CinA family
HEP84_RS36805	COG1546	Belongs to the CinA family
HEP84_RS36810	COG1396	sequence-specific DNA binding
HEP84_RS36815	COG0783	Belongs to the Dps family
HEP84_RS36820	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS36825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP84_RS36830	COG1201	RNA secondary structure unwinding
HEP84_RS36860	COG0628	permease
HEP84_RS36870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HEP84_RS36905	COG0765	amino acid transport
HEP84_RS36910	COG0765	amino acid transport
HEP84_RS36915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEP84_RS36920	COG1126	abc transporter atp-binding protein
HEP84_RS36925	COG0745	RESPONSE REGULATOR receiver
HEP84_RS36930	COG2205	protein histidine kinase activity
HEP84_RS36960	COG2197	response regulator
HEP84_RS36995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HEP84_RS37015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEP84_RS37025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HEP84_RS37030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEP84_RS37040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEP84_RS37090	COG1136	(ABC) transporter
HEP84_RS37090	COG0577	efflux transmembrane transporter activity
HEP84_RS37095	COG4585	Histidine kinase
HEP84_RS37100	COG2197	response regulator
HEP84_RS37125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS37130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS37175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS37210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEP84_RS37215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HEP84_RS37220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEP84_RS37255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HEP84_RS37290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEP84_RS37295	COG1802	Transcriptional regulator
HEP84_RS37300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP84_RS37315	COG0187	DNA topoisomerase II activity
HEP84_RS37330	COG2197	response regulator
HEP84_RS37340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEP84_RS37345	COG4565	transcriptional regulatory protein
HEP84_RS37355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS37365	COG4565	transcriptional regulatory protein
HEP84_RS37370	COG3290	protein histidine kinase activity
HEP84_RS37385	COG0372	Belongs to the citrate synthase family
HEP84_RS37405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HEP84_RS37410	COG0612	Peptidase, M16
HEP84_RS37425	COG1802	Transcriptional regulator
HEP84_RS37430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEP84_RS37450	COG1435	thymidine kinase activity
HEP84_RS37500	COG0745	RESPONSE REGULATOR receiver
HEP84_RS37505	COG2205	protein histidine kinase activity
HEP84_RS37530	COG0756	dUTP diphosphatase activity
HEP84_RS37545	COG1136	(ABC) transporter
HEP84_RS37575	COG0569	domain protein
HEP84_RS37580	COG0531	amino acid
HEP84_RS37585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HEP84_RS37600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEP84_RS37605	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HEP84_RS37615	COG1215	transferase activity, transferring glycosyl groups
HEP84_RS37625	COG4310	Domain of unknown function (DUF2172)
HEP84_RS37640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HEP84_RS37650	COG0438	transferase activity, transferring glycosyl groups
HEP84_RS37675	COG0367	asparagine synthase
HEP84_RS37695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HEP84_RS37725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP84_RS37735	COG0640	Transcriptional regulator
HEP84_RS37765	COG2409	Drug exporters of the RND superfamily
HEP84_RS37780	COG0243	molybdopterin cofactor binding
HEP84_RS37785	COG1799	cell septum assembly
HEP84_RS37805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS37815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HEP84_RS37830	COG2235	arginine
HEP84_RS37835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP84_RS37840	COG0531	amino acid
HEP84_RS37850	COG1024	Enoyl-CoA hydratase
HEP84_RS37900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HEP84_RS37915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HEP84_RS37925	COG1404	Belongs to the peptidase S8 family
HEP84_RS37940	COG2205	protein histidine kinase activity
HEP84_RS37950	COG3537	Alpha-1,2-mannosidase
HEP84_RS37960	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS37970	COG1653	transport
HEP84_RS37975	COG1175	transmembrane transport
HEP84_RS37980	COG0395	ABC-type sugar transport system, permease component
HEP84_RS37985	COG1940	carbohydrate kinase activity
HEP84_RS37990	COG4213	ABC transporter substrate-binding protein
HEP84_RS38000	COG4214	carbohydrate transport
HEP84_RS38005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP84_RS38010	COG0531	amino acid
HEP84_RS38040	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS38040	COG1024	Enoyl-CoA hydratase
HEP84_RS38045	COG0183	Belongs to the thiolase family
HEP84_RS38050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEP84_RS38065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HEP84_RS38080	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP84_RS38115	COG3220	belongs to the UPF0276 family
HEP84_RS38160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HEP84_RS38200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEP84_RS38205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HEP84_RS38230	COG4999	Histidine kinase
HEP84_RS38230	COG3850	Histidine kinase
HEP84_RS38230	COG3437	response regulator, receiver
HEP84_RS38230	COG2205	protein histidine kinase activity
HEP84_RS38265	COG0154	amidase activity
HEP84_RS38280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HEP84_RS38305	COG0642	Histidine kinase
HEP84_RS38325	COG2197	response regulator
HEP84_RS38330	COG4585	Histidine kinase
HEP84_RS38400	COG1404	Belongs to the peptidase S8 family
HEP84_RS38430	COG0504	CTP synthase activity
HEP84_RS38440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEP84_RS38455	COG3173	Aminoglycoside phosphotransferase
HEP84_RS38565	COG0667	Aldo Keto reductase
HEP84_RS38585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HEP84_RS38600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS38605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HEP84_RS38630	COG0529	Catalyzes the synthesis of activated sulfate
HEP84_RS38635	COG0175	sulfate reduction
HEP84_RS38665	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS38680	COG1917	Cupin 2, conserved barrel domain protein
HEP84_RS38680	COG4977	sequence-specific DNA binding
HEP84_RS38720	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP84_RS38730	COG1175	transmembrane transport
HEP84_RS38750	COG1940	carbohydrate kinase activity
HEP84_RS38765	COG1175	transmembrane transport
HEP84_RS38770	COG0395	ABC-type sugar transport system, permease component
HEP84_RS38800	COG1609	Transcriptional regulator
HEP84_RS38840	COG2040	homocysteine
HEP84_RS38995	COG3619	membrane
HEP84_RS39000	COG1335	isochorismatase
HEP84_RS39030	COG1131	(ABC) transporter
HEP84_RS39035	COG2814	Major facilitator Superfamily
HEP84_RS39045	COG0395	ABC-type sugar transport system, permease component
HEP84_RS39050	COG1175	transmembrane transport
HEP84_RS39065	COG0277	FAD linked oxidase domain protein
HEP84_RS39160	COG1162	GTPase activity
HEP84_RS39170	COG3340	Belongs to the peptidase S51 family
HEP84_RS39210	COG0028	Belongs to the TPP enzyme family
HEP84_RS39230	COG1802	Transcriptional regulator
HEP84_RS39260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP84_RS39265	COG2252	PERMEase
HEP84_RS39295	COG0726	polysaccharide deacetylase
HEP84_RS39300	COG0673	inositol 2-dehydrogenase activity
HEP84_RS39310	COG1175	transmembrane transport
HEP84_RS39315	COG0395	ABC-type sugar transport system, permease component
HEP84_RS39330	COG2814	Major facilitator Superfamily
HEP84_RS39335	COG1132	(ABC) transporter
HEP84_RS39345	COG2945	thiolester hydrolase activity
HEP84_RS39345	COG0596	Alpha beta hydrolase
HEP84_RS39350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP84_RS39370	COG1477	protein flavinylation
HEP84_RS39385	COG0745	RESPONSE REGULATOR receiver
HEP84_RS39390	COG2205	protein histidine kinase activity
HEP84_RS39410	COG3903	Transcriptional regulator
HEP84_RS39410	COG3629	intracellular signal transduction
HEP84_RS39435	COG0235	Class ii aldolase
HEP84_RS39440	COG2160	L-arabinose isomerase activity
HEP84_RS39470	COG3345	alpha-galactosidase
HEP84_RS39520	COG2508	Transcriptional regulator
HEP84_RS39525	COG4302	ethanolamine ammonia-lyase activity
HEP84_RS39535	COG2124	cytochrome p450
HEP84_RS39545	COG2986	histidine ammonia-lyase
HEP84_RS39550	COG0477	Major facilitator Superfamily
HEP84_RS39560	COG1968	undecaprenyl-diphosphatase activity
HEP84_RS39580	COG0745	RESPONSE REGULATOR receiver
HEP84_RS39620	COG4974	Belongs to the 'phage' integrase family
HEP84_RS39625	COG0598	Magnesium transport protein CorA
HEP84_RS39640	COG0583	DNA-binding transcription factor activity
HEP84_RS39655	COG4133	protoheme IX ABC transporter activity
HEP84_RS39660	COG2197	response regulator
HEP84_RS39665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP84_RS39670	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS39680	COG3960	tartronate-semialdehyde synthase activity
HEP84_RS39690	COG0753	catalase activity
HEP84_RS39695	COG2084	Dehydrogenase
HEP84_RS39700	COG3622	Belongs to the hyi family
HEP84_RS39720	COG2351	hydroxyisourate hydrolase activity
HEP84_RS39735	COG2233	PERMEase
HEP84_RS39750	COG1733	regulation of RNA biosynthetic process
HEP84_RS39765	COG0406	alpha-ribazole phosphatase activity
HEP84_RS39770	COG0436	Aminotransferase
HEP84_RS39785	COG2304	oxidoreductase activity
HEP84_RS39790	COG4264	IucA IucC family
HEP84_RS39800	COG0515	serine threonine protein kinase
HEP84_RS39815	COG1309	transcriptional regulator
HEP84_RS39825	COG1597	lipid kinase activity
HEP84_RS39885	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEP84_RS39935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HEP84_RS39935	COG2124	cytochrome p450
HEP84_RS39965	COG2197	response regulator
HEP84_RS39980	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEP84_RS40045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP84_RS40100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEP84_RS40115	COG1414	Transcriptional regulator
HEP84_RS40120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP84_RS40125	COG4266	Belongs to the allantoicase family
HEP84_RS40130	COG0598	Magnesium transport protein CorA
HEP84_RS40145	COG0667	Aldo Keto reductase
HEP84_RS40150	COG2197	response regulator
HEP84_RS40160	COG0673	inositol 2-dehydrogenase activity
HEP84_RS40165	COG2188	Transcriptional regulator
HEP84_RS40190	COG1940	carbohydrate kinase activity
HEP84_RS40200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HEP84_RS40240	COG0667	Aldo Keto reductase
HEP84_RS40260	COG3903	Transcriptional regulator
HEP84_RS40260	COG3629	intracellular signal transduction
HEP84_RS40290	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS40300	COG2197	response regulator
HEP84_RS40300	COG3903	Transcriptional regulator
HEP84_RS40305	COG3629	intracellular signal transduction
HEP84_RS40305	COG3903	Transcriptional regulator
HEP84_RS40315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS40320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEP84_RS40335	COG1126	abc transporter atp-binding protein
HEP84_RS40345	COG0765	amino acid transport
HEP84_RS40350	COG0765	amino acid transport
HEP84_RS40365	COG0405	Gamma-glutamyltransferase
HEP84_RS40405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HEP84_RS40415	COG1953	Uracil, thiamine, allantoin
HEP84_RS40425	COG2226	methyltransferase
HEP84_RS40435	COG3851	Histidine kinase
HEP84_RS40440	COG2197	response regulator
HEP84_RS40495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HEP84_RS40535	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEP84_RS40560	COG0483	inositol monophosphate 1-phosphatase activity
HEP84_RS40575	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEP84_RS40600	COG0745	RESPONSE REGULATOR receiver
HEP84_RS40605	COG2205	protein histidine kinase activity
HEP84_RS40625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP84_RS40665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HEP84_RS40675	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS40680	COG0583	DNA-binding transcription factor activity
HEP84_RS40690	COG0477	Major facilitator Superfamily
HEP84_RS40705	COG1309	transcriptional regulator
HEP84_RS40745	COG2205	protein histidine kinase activity
HEP84_RS40755	COG0671	phosphoesterase, PA-phosphatase related
HEP84_RS40785	COG0640	Transcriptional regulator
HEP84_RS40805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP84_RS40810	COG1192	Involved in chromosome partitioning
HEP84_RS40845	COG1929	Belongs to the glycerate kinase type-1 family
HEP84_RS40855	COG0688	phosphatidylethanolamine metabolic process
HEP84_RS40860	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS40870	COG2301	Belongs to the HpcH HpaI aldolase family
HEP84_RS40875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS40875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEP84_RS40880	COG0604	alcohol dehydrogenase
HEP84_RS40890	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS40900	COG0456	acetyltransferase
HEP84_RS40900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP84_RS40910	COG0596	Alpha beta hydrolase
HEP84_RS40935	COG2226	methyltransferase
HEP84_RS40975	COG2362	D-Aminopeptidase
HEP84_RS40980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEP84_RS40990	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEP84_RS41015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEP84_RS41025	COG2226	methyltransferase
HEP84_RS41035	COG0488	(ABC) transporter
HEP84_RS41125	COG0443	Heat shock 70 kDa protein
HEP84_RS41150	COG2154	pterin-4-alpha-carbinolamine dehydratase
HEP84_RS41160	COG0675	Transposase, IS605 OrfB family
HEP84_RS41165	COG2226	methyltransferase
HEP84_RS41180	COG2378	regulation of single-species biofilm formation
HEP84_RS41190	COG0778	Nitroreductase
HEP84_RS41200	COG4733	cellulase activity
HEP84_RS41200	COG5297	Belongs to the glycosyl hydrolase family 6
HEP84_RS41210	COG5297	Belongs to the glycosyl hydrolase family 6
HEP84_RS41230	COG4249	Peptidase C14 caspase catalytic subunit p20
HEP84_RS41230	COG2319	Wd-40 repeat
HEP84_RS41245	COG0656	L-ascorbic acid biosynthetic process
HEP84_RS41270	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEP84_RS41280	COG3469	chitinase activity
HEP84_RS41285	COG3250	beta-galactosidase activity
HEP84_RS41335	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HEP84_RS41375	COG1846	Transcriptional regulator
HEP84_RS41380	COG1335	isochorismatase
HEP84_RS41385	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS41390	COG0583	DNA-binding transcription factor activity
HEP84_RS41395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HEP84_RS41410	COG3383	formate dehydrogenase (NAD+) activity
HEP84_RS41415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEP84_RS41455	COG1940	carbohydrate kinase activity
HEP84_RS41460	COG1129	ABC transporter
HEP84_RS41465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP84_RS41470	COG1879	ABC-type sugar transport system periplasmic component
HEP84_RS41475	COG0673	inositol 2-dehydrogenase activity
HEP84_RS41485	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP84_RS41540	COG2223	nitrite transmembrane transporter activity
HEP84_RS41550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP84_RS41560	COG0045	succinate-CoA ligase (ADP-forming) activity
HEP84_RS41570	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS41620	COG0069	glutamate synthase activity
HEP84_RS41675	COG3012	SEC-C Motif Domain Protein
HEP84_RS41725	COG4221	oxidoreductase activity
HEP84_RS41740	COG0402	S-adenosylhomocysteine deaminase activity
HEP84_RS41775	COG0494	nUDIX hydrolase
HEP84_RS41780	COG0154	amidase activity
HEP84_RS41840	COG1063	alcohol dehydrogenase
HEP84_RS41855	COG1063	alcohol dehydrogenase
HEP84_RS41865	COG0655	NAD(P)H dehydrogenase (quinone) activity
HEP84_RS41895	COG2080	2 iron, 2 sulfur cluster binding
HEP84_RS41900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEP84_RS41905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEP84_RS41915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HEP84_RS41930	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS41960	COG2264	protein methyltransferase activity
HEP84_RS41965	COG0494	nUDIX hydrolase
HEP84_RS41975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP84_RS41995	COG1051	belongs to the nudix hydrolase family
HEP84_RS42000	COG1324	tolerance protein
HEP84_RS42015	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HEP84_RS42075	COG4221	oxidoreductase activity
HEP84_RS42090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP84_RS42095	COG0254	rRNA binding
HEP84_RS42105	COG4585	Histidine kinase
HEP84_RS42110	COG2197	response regulator
HEP84_RS42120	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS42170	COG0542	response to heat
HEP84_RS42185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP84_RS42205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP84_RS42215	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HEP84_RS42230	COG1063	alcohol dehydrogenase
HEP84_RS42240	COG0745	RESPONSE REGULATOR receiver
HEP84_RS42250	COG0477	Major facilitator Superfamily
HEP84_RS42255	COG2124	cytochrome p450
HEP84_RS42275	COG0477	Major facilitator Superfamily
HEP84_RS42310	COG2353	YceI-like domain
HEP84_RS42320	COG0765	amino acid transport
HEP84_RS42340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS42345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS42350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS42355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS42365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP84_RS42400	COG3629	intracellular signal transduction
HEP84_RS42400	COG3903	Transcriptional regulator
HEP84_RS42415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEP84_RS42420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP84_RS42440	COG0297	glycogen (starch) synthase activity
HEP84_RS42455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HEP84_RS42485	COG0477	Major facilitator Superfamily
HEP84_RS42495	COG3467	pyridoxamine 5'-phosphate
HEP84_RS42505	COG0477	Major facilitator Superfamily
HEP84_RS42535	COG0588	phosphoglycerate mutase activity
HEP84_RS42540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP84_RS42545	COG0166	Belongs to the GPI family
HEP84_RS42560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEP84_RS42575	COG2382	esterase
HEP84_RS42575	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP84_RS42575	COG3693	PFAM glycoside hydrolase, family 10
HEP84_RS42595	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS42620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEP84_RS42625	COG3250	beta-galactosidase activity
HEP84_RS42630	COG0395	ABC-type sugar transport system, permease component
HEP84_RS42635	COG1175	transmembrane transport
HEP84_RS42645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS42650	COG1349	DNA-binding transcription factor activity
HEP84_RS42655	COG1486	melibiose metabolic process
HEP84_RS42675	COG0675	Transposase, IS605 OrfB family
HEP84_RS42685	COG3469	chitinase activity
HEP84_RS42750	COG3842	ATPase activity
HEP84_RS42755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEP84_RS42760	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEP84_RS42765	COG1177	transmembrane transport
HEP84_RS42840	COG1335	isochorismatase
HEP84_RS42845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP84_RS42850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEP84_RS42855	COG0805	protein transport
HEP84_RS42860	COG0477	Major facilitator Superfamily
HEP84_RS42955	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS42985	COG1802	Transcriptional regulator
HEP84_RS42990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEP84_RS43020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HEP84_RS43045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEP84_RS43090	COG0492	ferredoxin-NADP+ reductase activity
HEP84_RS43120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEP84_RS43125	COG3938	Belongs to the proline racemase family
HEP84_RS43145	COG1175	transmembrane transport
HEP84_RS43150	COG0395	ABC-type sugar transport system, permease component
HEP84_RS43155	COG0366	Alpha amylase catalytic
HEP84_RS43175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS43180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS43255	COG3511	phospholipase C
HEP84_RS43285	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HEP84_RS43290	COG0477	Major facilitator Superfamily
HEP84_RS43300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HEP84_RS43310	COG3485	protocatechuate 3,4-dioxygenase
HEP84_RS43315	COG3485	protocatechuate 3,4-dioxygenase
HEP84_RS43320	COG0183	Belongs to the thiolase family
HEP84_RS43335	COG1846	Transcriptional regulator
HEP84_RS43345	COG0714	Associated with various cellular activities
HEP84_RS43360	COG1793	dna ligase
HEP84_RS43410	COG3344	reverse transcriptase
HEP84_RS43490	COG1834	amidinotransferase
HEP84_RS43495	COG0488	(ABC) transporter
HEP84_RS43535	COG3268	Saccharopine dehydrogenase
HEP84_RS43540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HEP84_RS43545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS43550	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS43555	COG0183	Belongs to the thiolase family
HEP84_RS43560	COG1024	Enoyl-CoA hydratase
HEP84_RS43560	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS43565	COG0789	Transcriptional regulator
HEP84_RS43570	COG1113	amino acid transport
HEP84_RS43590	COG2936	dipeptidyl-peptidase activity
HEP84_RS43605	COG0488	(ABC) transporter
HEP84_RS43615	COG2183	response to ionizing radiation
HEP84_RS43625	COG4977	sequence-specific DNA binding
HEP84_RS43635	COG1024	Enoyl-CoA hydratase
HEP84_RS43650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEP84_RS43700	COG1134	teichoic acid transport
HEP84_RS43705	COG1562	ergosterol biosynthetic process
HEP84_RS43725	COG1657	PFAM Prenyltransferase squalene oxidase
HEP84_RS43740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HEP84_RS43745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEP84_RS43765	COG2365	Tyrosine phosphatase family
HEP84_RS43780	COG2226	methyltransferase
HEP84_RS43835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS43900	COG1063	alcohol dehydrogenase
HEP84_RS43905	COG0156	8-amino-7-oxononanoate synthase activity
HEP84_RS43910	COG0583	DNA-binding transcription factor activity
HEP84_RS43945	COG3958	Transketolase
HEP84_RS43950	COG3959	Transketolase, thiamine diphosphate binding domain
HEP84_RS43965	COG1132	(ABC) transporter
HEP84_RS43995	COG3033	Beta-eliminating lyase
HEP84_RS44015	COG1937	Protein conserved in bacteria
HEP84_RS44030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEP84_RS44035	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP84_RS44055	COG3239	Fatty acid desaturase
HEP84_RS44060	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HEP84_RS44165	COG1454	alcohol dehydrogenase
HEP84_RS44170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HEP84_RS44175	COG0351	phosphomethylpyrimidine kinase
HEP84_RS44180	COG0702	epimerase
HEP84_RS44255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP84_RS44290	COG0668	transmembrane transport
HEP84_RS44295	COG1024	Enoyl-CoA hydratase
HEP84_RS44310	COG2409	Drug exporters of the RND superfamily
HEP84_RS44315	COG1309	transcriptional regulator
HEP84_RS44335	COG0473	3-isopropylmalate dehydrogenase activity
HEP84_RS44345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP84_RS44375	COG3483	tryptophan 2,3-dioxygenase activity
HEP84_RS44390	COG0475	glutathione-regulated potassium exporter activity
HEP84_RS44395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HEP84_RS44410	COG2264	protein methyltransferase activity
HEP84_RS44440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP84_RS44455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEP84_RS44460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HEP84_RS44465	COG0697	spore germination
HEP84_RS44470	COG1509	lysine 2,3-aminomutase activity
HEP84_RS44480	COG0579	oxidoreductase
HEP84_RS44495	COG2197	response regulator
HEP84_RS44550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEP84_RS44565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HEP84_RS44585	COG0297	glycogen (starch) synthase activity
HEP84_RS44590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HEP84_RS44615	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS44625	COG0701	Predicted permease
HEP84_RS44660	COG1609	Transcriptional regulator
HEP84_RS44670	COG1175	transmembrane transport
HEP84_RS44675	COG0395	ABC-type sugar transport system, permease component
HEP84_RS44695	COG2186	Transcriptional regulator
HEP84_RS44705	COG1129	ABC transporter
HEP84_RS44710	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP84_RS44715	COG4948	Mandelate Racemase Muconate Lactonizing
HEP84_RS44720	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS44755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEP84_RS44790	COG0726	polysaccharide deacetylase
HEP84_RS44845	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS44860	COG1053	succinate dehydrogenase
HEP84_RS44865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEP84_RS44885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS44900	COG0667	Aldo Keto reductase
HEP84_RS44905	COG1376	ErfK ybiS ycfS ynhG family protein
HEP84_RS44960	COG1595	DNA-templated transcription, initiation
HEP84_RS45000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HEP84_RS45005	COG0121	glutamine amidotransferase
HEP84_RS45010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP84_RS45015	COG3572	ergothioneine biosynthetic process
HEP84_RS45035	COG2268	Band 7 protein
HEP84_RS45050	COG1609	Transcriptional regulator
HEP84_RS45065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEP84_RS45075	COG0242	peptide deformylase activity
HEP84_RS45140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HEP84_RS45145	COG0363	glucosamine-6-phosphate deaminase activity
HEP84_RS45180	COG2890	protein-(glutamine-N5) methyltransferase activity
HEP84_RS45300	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS45305	COG3962	Belongs to the TPP enzyme family
HEP84_RS45335	COG0673	inositol 2-dehydrogenase activity
HEP84_RS45340	COG0673	inositol 2-dehydrogenase activity
HEP84_RS45360	COG1609	Transcriptional regulator
HEP84_RS45365	COG3537	Alpha-1,2-mannosidase
HEP84_RS45380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP84_RS45415	COG1122	ATPase activity
HEP84_RS45420	COG1122	ATPase activity
HEP84_RS45455	COG0561	phosphatase activity
HEP84_RS45530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP84_RS45535	COG2151	metal-sulfur cluster biosynthetic enzyme
HEP84_RS45540	COG3396	Phenylacetate-CoA oxygenase
HEP84_RS45545	COG3460	Phenylacetate-CoA oxygenase
HEP84_RS45550	COG3396	Phenylacetate-CoA oxygenase
HEP84_RS45555	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEP84_RS45575	COG2050	protein possibly involved in aromatic compounds catabolism
HEP84_RS45590	COG0531	amino acid
HEP84_RS45665	COG3507	Belongs to the glycosyl hydrolase 43 family
HEP84_RS45680	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEP84_RS45710	COG0375	protein maturation
HEP84_RS45715	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP84_RS45720	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEP84_RS45725	COG0298	carbon dioxide binding
HEP84_RS45730	COG0409	Hydrogenase expression formation protein
HEP84_RS45735	COG0309	Hydrogenase expression formation protein (HypE)
HEP84_RS45765	COG1141	Ferredoxin
HEP84_RS45800	COG1174	glycine betaine transport
HEP84_RS45805	COG1174	glycine betaine transport
HEP84_RS45840	COG1556	Lactate utilization protein
HEP84_RS45845	COG1139	Iron-sulfur cluster binding protein
HEP84_RS45850	COG0247	lactate metabolic process
HEP84_RS45855	COG1070	Carbohydrate kinase
HEP84_RS45860	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS45860	COG3347	Dehydrogenase
HEP84_RS45870	COG1129	ABC transporter
HEP84_RS45885	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP84_RS45905	COG1609	Transcriptional regulator
HEP84_RS45915	COG1595	DNA-templated transcription, initiation
HEP84_RS45920	COG1357	PFAM Pentapeptide repeats (8 copies)
HEP84_RS45930	COG1309	transcriptional regulator
HEP84_RS45940	COG2706	6-phosphogluconolactonase activity
HEP84_RS45965	COG3321	synthase
HEP84_RS45965	COG0604	alcohol dehydrogenase
HEP84_RS45965	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS45990	COG2723	6-phospho-beta-galactosidase activity
HEP84_RS45995	COG0395	ABC-type sugar transport system, permease component
HEP84_RS46000	COG1175	transmembrane transport
HEP84_RS46005	COG2182	Extracellular solute-binding protein
HEP84_RS46030	COG2267	carboxylic ester hydrolase activity
HEP84_RS46040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HEP84_RS46040	COG1796	DNA polymerase
HEP84_RS46080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEP84_RS46115	COG0515	serine threonine protein kinase
HEP84_RS46145	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS46145	COG0604	alcohol dehydrogenase
HEP84_RS46145	COG3321	synthase
HEP84_RS46155	COG1063	alcohol dehydrogenase
HEP84_RS46180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HEP84_RS46200	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS46240	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS46265	COG0531	amino acid
HEP84_RS46305	COG2124	cytochrome p450
HEP84_RS46345	COG0596	Alpha beta hydrolase
HEP84_RS46380	COG3250	beta-galactosidase activity
HEP84_RS46385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HEP84_RS46420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEP84_RS46450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS46465	COG4209	transmembrane transport
HEP84_RS46470	COG0395	ABC-type sugar transport system, permease component
HEP84_RS46495	COG0671	phosphoesterase, PA-phosphatase related
HEP84_RS46510	COG3832	glyoxalase III activity
HEP84_RS46555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEP84_RS46555	COG2755	lipolytic protein G-D-S-L family
HEP84_RS46570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEP84_RS46630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEP84_RS46645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HEP84_RS46670	COG1132	(ABC) transporter
HEP84_RS46745	COG1940	carbohydrate kinase activity
HEP84_RS46745	COG1846	Transcriptional regulator
HEP84_RS46835	COG4948	Mandelate Racemase Muconate Lactonizing
HEP84_RS46850	COG0583	DNA-binding transcription factor activity
HEP84_RS46870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HEP84_RS46930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HEP84_RS46945	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS47000	COG0443	Heat shock 70 kDa protein
HEP84_RS47005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP84_RS47035	COG0831	urea catabolic process
HEP84_RS47035	COG0832	Belongs to the urease beta subunit family
HEP84_RS47040	COG0804	urea catabolic process
HEP84_RS47050	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEP84_RS47055	COG0829	nickel cation binding
HEP84_RS47105	COG3385	transposase activity
HEP84_RS47220	COG3385	transposase activity
HEP84_RS47240	COG4977	sequence-specific DNA binding
HEP84_RS47245	COG0483	inositol monophosphate 1-phosphatase activity
HEP84_RS47265	COG0583	DNA-binding transcription factor activity
HEP84_RS47280	COG2197	response regulator
HEP84_RS47290	COG2272	Belongs to the type-B carboxylesterase lipase family
HEP84_RS47310	COG3285	dna ligase
HEP84_RS47310	COG1793	dna ligase
HEP84_RS47345	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS47415	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HEP84_RS47420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HEP84_RS47425	COG1984	allophanate hydrolase subunit 2
HEP84_RS47430	COG0477	Major facilitator Superfamily
HEP84_RS47435	COG4221	oxidoreductase activity
HEP84_RS47445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEP84_RS47455	COG1802	Transcriptional regulator
HEP84_RS47485	COG1522	sequence-specific DNA binding
HEP84_RS47545	COG0583	DNA-binding transcription factor activity
HEP84_RS47560	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS47590	COG3896	Chloramphenicol phosphotransferase-like protein
HEP84_RS47600	COG0509	glycine decarboxylation via glycine cleavage system
HEP84_RS47710	COG1278	Cold shock
HEP84_RS47740	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HEP84_RS47745	COG0714	Associated with various cellular activities
HEP84_RS47775	COG0596	Alpha beta hydrolase
HEP84_RS47790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEP84_RS47805	COG1940	carbohydrate kinase activity
HEP84_RS47815	COG1175	transmembrane transport
HEP84_RS47820	COG0395	ABC-type sugar transport system, permease component
HEP84_RS47855	COG3385	transposase activity
HEP84_RS47895	COG2340	Cysteine-rich secretory protein family
HEP84_RS47945	COG3469	chitinase activity
HEP84_RS47955	COG3548	integral membrane protein
HEP84_RS47965	COG0667	Aldo Keto reductase
HEP84_RS47975	COG3537	Alpha-1,2-mannosidase
HEP84_RS47995	COG1228	amidohydrolase
HEP84_RS48000	COG0515	serine threonine protein kinase
HEP84_RS48010	COG3250	beta-galactosidase activity
HEP84_RS48035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEP84_RS48045	COG1937	Protein conserved in bacteria
HEP84_RS48080	COG2378	regulation of single-species biofilm formation
HEP84_RS48085	COG4552	Acetyltransferase involved in intracellular survival and related
HEP84_RS48115	COG1175	transmembrane transport
HEP84_RS48120	COG0395	ABC-type sugar transport system, permease component
HEP84_RS48140	COG3345	alpha-galactosidase
HEP84_RS48150	COG0667	Aldo Keto reductase
HEP84_RS48155	COG1335	isochorismatase
HEP84_RS48175	COG3852	Histidine kinase
HEP84_RS48210	COG3290	protein histidine kinase activity
HEP84_RS48220	COG2814	Major facilitator Superfamily
HEP84_RS48225	COG0640	Transcriptional regulator
HEP84_RS48245	COG1716	ATPase activity
HEP84_RS48245	COG1131	(ABC) transporter
HEP84_RS48245	COG0842	Transport permease protein
HEP84_RS48280	COG1196	nuclear chromosome segregation
HEP84_RS48280	COG0741	lytic transglycosylase activity
HEP84_RS48280	COG0739	heme binding
HEP84_RS48300	COG0583	DNA-binding transcription factor activity
HEP84_RS48305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEP84_RS48330	COG2197	response regulator
HEP84_RS48350	COG0395	ABC-type sugar transport system, permease component
HEP84_RS48360	COG1609	Transcriptional regulator
HEP84_RS48365	COG1335	isochorismatase
HEP84_RS48395	COG1595	DNA-templated transcription, initiation
HEP84_RS48430	COG5002	protein histidine kinase activity
HEP84_RS48450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEP84_RS48470	COG2318	DinB family
HEP84_RS48480	COG2318	DinB family
HEP84_RS48525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEP84_RS48525	COG1017	nitric oxide dioxygenase activity
HEP84_RS48555	COG1595	DNA-templated transcription, initiation
HEP84_RS48595	COG2197	response regulator
HEP84_RS48620	COG4191	Histidine kinase
HEP84_RS48630	COG2239	Acts as a magnesium transporter
HEP84_RS48670	COG2326	polyphosphate kinase activity
HEP84_RS48675	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HEP84_RS48680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEP84_RS48705	COG0517	IMP dehydrogenase activity
HEP84_RS48705	COG0516	GMP reductase activity
HEP84_RS48725	COG0517	IMP dehydrogenase activity
HEP84_RS48725	COG0516	GMP reductase activity
HEP84_RS48740	COG0574	Belongs to the PEP-utilizing enzyme family
HEP84_RS48740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEP84_RS48790	COG1063	alcohol dehydrogenase
HEP84_RS48805	COG0531	amino acid
HEP84_RS48810	COG2235	arginine
HEP84_RS48815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEP84_RS48820	COG0549	Belongs to the carbamate kinase family
HEP84_RS48830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEP84_RS48865	COG1309	transcriptional regulator
HEP84_RS48870	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS48885	COG1278	Cold shock
HEP84_RS48890	COG0513	Belongs to the DEAD box helicase family
HEP84_RS48990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HEP84_RS49015	COG2366	antibiotic biosynthetic process
HEP84_RS49070	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HEP84_RS49095	COG0789	Transcriptional regulator
HEP84_RS49155	COG1132	(ABC) transporter
HEP84_RS49195	COG2130	NADP-dependent
HEP84_RS49200	COG0789	Transcriptional regulator
HEP84_RS49205	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS49210	COG1414	Transcriptional regulator
HEP84_RS49225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEP84_RS49270	COG1335	isochorismatase
HEP84_RS49320	COG0583	DNA-binding transcription factor activity
HEP84_RS49355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEP84_RS49365	COG2837	iron assimilation
HEP84_RS49390	COG2207	Transcriptional regulator
HEP84_RS49425	COG0640	Transcriptional regulator
HEP84_RS49505	COG1309	transcriptional regulator
HEP84_RS49525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEP84_RS49530	COG1129	ABC transporter
HEP84_RS49535	COG2208	phosphoserine phosphatase activity
HEP84_RS49555	COG0306	phosphate transporter
HEP84_RS49560	COG3629	intracellular signal transduction
HEP84_RS49560	COG3903	Transcriptional regulator
HEP84_RS49575	COG1408	metallophosphoesterase
HEP84_RS49590	COG3629	intracellular signal transduction
HEP84_RS49590	COG3903	Transcriptional regulator
HEP84_RS49670	COG0596	Alpha beta hydrolase
HEP84_RS49685	COG1132	(ABC) transporter
HEP84_RS49690	COG1132	(ABC) transporter
HEP84_RS49700	COG1271	oxidase subunit
HEP84_RS49730	COG0577	efflux transmembrane transporter activity
HEP84_RS49730	COG1136	(ABC) transporter
HEP84_RS49775	COG1175	transmembrane transport
HEP84_RS49795	COG2814	Major facilitator Superfamily
HEP84_RS49800	COG3619	membrane
HEP84_RS49805	COG2259	Doxx family
HEP84_RS49810	COG1335	isochorismatase
HEP84_RS49835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEP84_RS49840	COG0783	Belongs to the Dps family
HEP84_RS49895	COG1136	(ABC) transporter
HEP84_RS49940	COG0587	DNA-directed DNA polymerase activity
HEP84_RS49950	COG0300	oxidoreductase activity
HEP84_RS49965	COG1309	transcriptional regulator
HEP84_RS50110	COG2175	clavaminate synthase activity
HEP84_RS50115	COG2814	Major facilitator Superfamily
HEP84_RS50125	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS50150	COG0515	serine threonine protein kinase
HEP84_RS50155	COG0202	RNA polymerase activity
HEP84_RS50175	COG1309	transcriptional regulator
HEP84_RS50255	COG0542	response to heat
HEP84_RS50265	COG0484	heat shock protein binding
HEP84_RS50270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP84_RS50335	COG4608	Belongs to the ABC transporter superfamily
HEP84_RS50340	COG0444	Belongs to the ABC transporter superfamily
HEP84_RS50350	COG0601	transmembrane transport
HEP84_RS50355	COG0747	negative chemotaxis
HEP84_RS50365	COG0667	Aldo Keto reductase
HEP84_RS50485	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HEP84_RS50500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEP84_RS50510	COG1621	beta-fructofuranosidase activity
HEP84_RS50520	COG1653	transport
HEP84_RS50525	COG1175	transmembrane transport
HEP84_RS50530	COG0395	ABC-type sugar transport system, permease component
HEP84_RS50545	COG2267	carboxylic ester hydrolase activity
HEP84_RS50560	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS50575	COG1511	domain protein
HEP84_RS50580	COG0321	lipoyl(octanoyl) transferase activity
HEP84_RS50605	COG2409	Drug exporters of the RND superfamily
HEP84_RS50615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP84_RS50635	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS50665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEP84_RS50670	COG0596	Alpha beta hydrolase
HEP84_RS50705	COG4221	oxidoreductase activity
HEP84_RS50730	COG0675	Transposase, IS605 OrfB family
HEP84_RS50830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HEP84_RS50835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HEP84_RS50840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEP84_RS50845	COG0254	rRNA binding
HEP84_RS50855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP84_RS50865	COG0701	Predicted permease
HEP84_RS50925	COG2508	Transcriptional regulator
HEP84_RS50930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HEP84_RS50960	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS50985	COG0076	glutamate decarboxylase activity
HEP84_RS51010	COG0477	Major facilitator Superfamily
HEP84_RS51090	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS51140	COG1522	sequence-specific DNA binding
HEP84_RS51210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS51220	COG4221	oxidoreductase activity
HEP84_RS51245	COG1595	DNA-templated transcription, initiation
HEP84_RS51280	COG2267	carboxylic ester hydrolase activity
HEP84_RS51315	COG0531	amino acid
HEP84_RS51320	COG4221	oxidoreductase activity
HEP84_RS51325	COG4941	Belongs to the sigma-70 factor family
HEP84_RS51330	COG3795	YCII-related domain
HEP84_RS51380	COG2175	clavaminate synthase activity
HEP84_RS51390	COG3246	L-lysine catabolic process to acetate
HEP84_RS51405	COG0318	PFAM AMP-dependent synthetase and ligase
HEP84_RS51420	COG2124	cytochrome p450
HEP84_RS51430	COG4585	Histidine kinase
HEP84_RS51435	COG2197	response regulator
HEP84_RS51490	COG2197	response regulator
HEP84_RS51495	COG4585	Histidine kinase
HEP84_RS51530	COG0277	FAD linked oxidase domain protein
HEP84_RS51535	COG1024	Enoyl-CoA hydratase
HEP84_RS51585	COG2267	carboxylic ester hydrolase activity
HEP84_RS51595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEP84_RS51615	COG2130	NADP-dependent
HEP84_RS51620	COG0789	Transcriptional regulator
HEP84_RS51655	COG2197	response regulator
HEP84_RS51670	COG1902	pentaerythritol trinitrate reductase activity
HEP84_RS51670	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEP84_RS51675	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS51680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEP84_RS51695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEP84_RS51750	COG0745	RESPONSE REGULATOR receiver
HEP84_RS51825	COG1309	transcriptional regulator
HEP84_RS51875	COG1720	tRNA m6t6A37 methyltransferase activity
HEP84_RS51915	COG1595	DNA-templated transcription, initiation
HEP84_RS51950	COG1733	regulation of RNA biosynthetic process
HEP84_RS52030	COG4977	sequence-specific DNA binding
HEP84_RS52035	COG2409	Drug exporters of the RND superfamily
HEP84_RS52045	COG2072	flavoprotein involved in K transport
HEP84_RS52050	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS52050	COG3347	Dehydrogenase
HEP84_RS52055	COG1012	belongs to the aldehyde dehydrogenase family
HEP84_RS52095	COG0300	oxidoreductase activity
HEP84_RS52105	COG0778	Nitroreductase
HEP84_RS52110	COG0667	Aldo Keto reductase
HEP84_RS52120	COG3851	Histidine kinase
HEP84_RS52125	COG2197	response regulator
HEP84_RS52215	COG0590	tRNA wobble adenosine to inosine editing
HEP84_RS52215	COG0037	tRNA processing
HEP84_RS52240	COG0659	secondary active sulfate transmembrane transporter activity
HEP84_RS52250	COG2824	Alkylphosphonate utilization operon protein PhnA
HEP84_RS52285	COG3547	Transposase (IS116 IS110 IS902 family)
HEP84_RS52320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HEP84_RS52355	COG1846	Transcriptional regulator
HEP84_RS52375	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HEP84_RS52375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEP84_RS52395	COG0531	amino acid
HEP84_RS52415	COG0539	negative regulation of cytoplasmic translation
HEP84_RS52440	COG0539	negative regulation of cytoplasmic translation
HEP84_RS52445	COG3285	dna ligase
HEP84_RS52445	COG1793	dna ligase
HEP84_RS52540	COG2318	DinB family
HEP84_RS52565	COG3335	DDE superfamily endonuclease
HEP84_RS52585	COG1595	DNA-templated transcription, initiation
HEP84_RS52610	COG2226	methyltransferase
HEP84_RS52665	COG0667	Aldo Keto reductase
HEP84_RS52865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEP84_RS52870	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS52875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP84_RS52890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEP84_RS52915	COG0667	Aldo Keto reductase
HEP84_RS52965	COG0477	Major facilitator Superfamily
HEP84_RS52970	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HEP84_RS53060	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS53070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEP84_RS53080	COG1309	transcriptional regulator
HEP84_RS53085	COG0702	epimerase
HEP84_RS53095	COG2850	peptidyl-arginine hydroxylation
HEP84_RS53115	COG2746	aminoglycoside 3-N-acetyltransferase activity
HEP84_RS53140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEP84_RS53200	COG3387	PFAM Glycoside hydrolase 15-related
HEP84_RS53240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEP84_RS53245	COG1595	DNA-templated transcription, initiation
HEP84_RS53375	COG2801	Transposase and inactivated derivatives
HEP84_RS53495	COG2226	methyltransferase
HEP84_RS53530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEP84_RS53540	COG0640	Transcriptional regulator
HEP84_RS53585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEP84_RS53680	COG0572	uridine kinase
HEP84_RS53690	COG4221	oxidoreductase activity
HEP84_RS53705	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS53740	COG3344	reverse transcriptase
HEP84_RS53760	COG3344	reverse transcriptase
HEP84_RS53775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HEP84_RS53815	COG1960	acyl-CoA dehydrogenase activity
HEP84_RS53820	COG1454	alcohol dehydrogenase
HEP84_RS53845	COG0583	DNA-binding transcription factor activity
HEP84_RS53850	COG0183	Belongs to the thiolase family
HEP84_RS53860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HEP84_RS53885	COG0006	proline dipeptidase activity
HEP84_RS53890	COG2084	Dehydrogenase
HEP84_RS53900	COG2188	Transcriptional regulator
HEP84_RS53910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HEP84_RS53915	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEP84_RS53925	COG1609	Transcriptional regulator
HEP84_RS53950	COG1131	(ABC) transporter
HEP84_RS53975	COG1335	isochorismatase
HEP84_RS53980	COG3619	membrane
HEP84_RS54020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEP84_RS54030	COG1116	anion transmembrane transporter activity
HEP84_RS54040	COG2353	YceI-like domain
HEP84_RS54045	COG1028	Short-chain dehydrogenase reductase Sdr
HEP84_RS54145	COG2319	Wd-40 repeat
HEP84_RS54145	COG4249	Peptidase C14 caspase catalytic subunit p20
HEP84_RS54370	COG1469	GTP cyclohydrolase I activity
HEP84_RS54375	COG0720	synthase
HEP84_RS54380	COG0602	queuosine metabolic process
HEP84_RS54385	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HEP84_RS54450	COG0514	ATP-dependent DNA helicase (RecQ)
HEP84_RS54495	COG2801	Transposase and inactivated derivatives
HEP84_RS54500	COG2826	transposase and inactivated derivatives, IS30 family
HEP84_RS54530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HEP84_RS54550	COG0174	glutamine synthetase
HEP84_RS54675	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HEP84_RS54795	COG0515	serine threonine protein kinase
HEP84_RS54795	COG2815	serine threonine protein kinase
HEP84_RS54800	COG0515	serine threonine protein kinase
HEP84_RS54850	COG0297	glycogen (starch) synthase activity
HEP84_RS54855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEP84_RS54875	COG0202	RNA polymerase activity
HEP84_RS54895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEP84_RS54930	COG2226	methyltransferase