locus-tag	class	description
FNV58_RS00155	COG1475	DNA binding
FNV58_RS00170	COG1278	Cold shock
FNV58_RS00215	COG4974	Belongs to the 'phage' integrase family
FNV58_RS00260	COG1131	(ABC) transporter
FNV58_RS00410	COG2188	Transcriptional regulator
FNV58_RS00430	COG0546	phosphoglycolate phosphatase activity
FNV58_RS00455	COG0305	Participates in initiation and elongation during chromosome replication
FNV58_RS00480	COG1857	crispr-associated protein
FNV58_RS00635	COG4195	phage-related replication protein
FNV58_RS00690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV58_RS00690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV58_RS00750	COG0587	DNA-directed DNA polymerase activity
FNV58_RS00765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FNV58_RS01270	COG0717	Belongs to the dCTP deaminase family
FNV58_RS01420	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FNV58_RS01505	COG1278	Cold shock
FNV58_RS01590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV58_RS01605	COG2197	response regulator
FNV58_RS01650	COG0596	Alpha beta hydrolase
FNV58_RS01705	COG0596	Alpha beta hydrolase
FNV58_RS01765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FNV58_RS01975	COG1959	2 iron, 2 sulfur cluster binding
FNV58_RS02020	COG0477	Major facilitator Superfamily
FNV58_RS02130	COG2124	cytochrome p450
FNV58_RS02185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FNV58_RS02200	COG1733	regulation of RNA biosynthetic process
FNV58_RS02205	COG0604	alcohol dehydrogenase
FNV58_RS02220	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV58_RS02320	COG0659	secondary active sulfate transmembrane transporter activity
FNV58_RS02330	COG2824	Alkylphosphonate utilization operon protein PhnA
FNV58_RS02370	COG1136	(ABC) transporter
FNV58_RS02410	COG0456	acetyltransferase
FNV58_RS02430	COG0702	epimerase
FNV58_RS02490	COG2267	carboxylic ester hydrolase activity
FNV58_RS02495	COG2197	response regulator
FNV58_RS02545	COG2130	NADP-dependent
FNV58_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS02635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FNV58_RS02665	COG0671	phosphoesterase, PA-phosphatase related
FNV58_RS02680	COG2814	Major facilitator Superfamily
FNV58_RS02700	COG0726	polysaccharide deacetylase
FNV58_RS02720	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV58_RS02725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV58_RS02765	COG2267	carboxylic ester hydrolase activity
FNV58_RS02830	COG4585	Histidine kinase
FNV58_RS02835	COG2197	response regulator
FNV58_RS02855	COG1278	Cold shock
FNV58_RS02870	COG0596	Alpha beta hydrolase
FNV58_RS02875	COG2045	Belongs to the ComB family
FNV58_RS02915	COG3293	Transposase
FNV58_RS03065	COG3629	intracellular signal transduction
FNV58_RS03065	COG3903	Transcriptional regulator
FNV58_RS03085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV58_RS03110	COG0583	DNA-binding transcription factor activity
FNV58_RS03120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV58_RS03150	COG0640	Transcriptional regulator
FNV58_RS03180	COG1609	Transcriptional regulator
FNV58_RS03185	COG2723	6-phospho-beta-galactosidase activity
FNV58_RS03200	COG3250	beta-galactosidase activity
FNV58_RS03205	COG3250	beta-galactosidase activity
FNV58_RS03220	COG3507	Belongs to the glycosyl hydrolase 43 family
FNV58_RS03230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV58_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS03270	COG3250	beta-galactosidase activity
FNV58_RS03305	COG3290	protein histidine kinase activity
FNV58_RS03330	COG1131	(ABC) transporter
FNV58_RS03340	COG1595	DNA-templated transcription, initiation
FNV58_RS03425	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FNV58_RS03435	COG1309	transcriptional regulator
FNV58_RS03510	COG0745	RESPONSE REGULATOR receiver
FNV58_RS03515	COG2205	protein histidine kinase activity
FNV58_RS03545	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV58_RS03570	COG4585	Histidine kinase
FNV58_RS03575	COG2197	response regulator
FNV58_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS03585	COG0567	Dehydrogenase, E1 component
FNV58_RS03585	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV58_RS03605	COG1090	epimerase
FNV58_RS03610	COG1595	DNA-templated transcription, initiation
FNV58_RS03630	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV58_RS03640	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS03670	COG0778	Nitroreductase
FNV58_RS03675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV58_RS03680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS03710	COG1063	alcohol dehydrogenase
FNV58_RS03715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FNV58_RS03715	COG2124	cytochrome p450
FNV58_RS03755	COG1309	transcriptional regulator
FNV58_RS03770	COG1660	Displays ATPase and GTPase activities
FNV58_RS03785	COG0596	Alpha beta hydrolase
FNV58_RS03970	COG2890	protein-(glutamine-N5) methyltransferase activity
FNV58_RS03990	COG0069	glutamate synthase activity
FNV58_RS03995	COG0028	Belongs to the TPP enzyme family
FNV58_RS04000	COG0596	Alpha beta hydrolase
FNV58_RS04010	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV58_RS04020	COG1024	Enoyl-CoA hydratase
FNV58_RS04055	COG1120	ATPase activity
FNV58_RS04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV58_RS04070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS04075	COG3433	isochorismatase activity
FNV58_RS04075	COG1535	isochorismatase
FNV58_RS04095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS04150	COG2226	methyltransferase
FNV58_RS04190	COG1522	sequence-specific DNA binding
FNV58_RS04205	COG0667	Aldo Keto reductase
FNV58_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS04260	COG3537	Alpha-1,2-mannosidase
FNV58_RS04265	COG0667	Aldo Keto reductase
FNV58_RS04270	COG1309	transcriptional regulator
FNV58_RS04275	COG3619	membrane
FNV58_RS04280	COG0583	DNA-binding transcription factor activity
FNV58_RS04285	COG3876	Protein conserved in bacteria
FNV58_RS04300	COG1175	transmembrane transport
FNV58_RS04305	COG0395	ABC-type sugar transport system, permease component
FNV58_RS04320	COG1902	pentaerythritol trinitrate reductase activity
FNV58_RS04340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS04355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV58_RS04365	COG1073	alpha beta
FNV58_RS04370	COG1024	Enoyl-CoA hydratase
FNV58_RS04380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FNV58_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS04425	COG1309	transcriptional regulator
FNV58_RS04430	COG0655	NAD(P)H dehydrogenase (quinone) activity
FNV58_RS04440	COG1733	regulation of RNA biosynthetic process
FNV58_RS04455	COG1309	transcriptional regulator
FNV58_RS04475	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS04480	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS04490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS04500	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS04510	COG1024	Enoyl-CoA hydratase
FNV58_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS04520	COG1309	transcriptional regulator
FNV58_RS04525	COG0667	Aldo Keto reductase
FNV58_RS04530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FNV58_RS04555	COG0800	Aldolase
FNV58_RS04565	COG4948	Mandelate Racemase Muconate Lactonizing
FNV58_RS04585	COG0395	ABC-type sugar transport system, permease component
FNV58_RS04590	COG1175	transmembrane transport
FNV58_RS04600	COG3345	alpha-galactosidase
FNV58_RS04605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV58_RS04635	COG1309	transcriptional regulator
FNV58_RS04665	COG0366	Alpha amylase catalytic
FNV58_RS04675	COG2207	Transcriptional regulator
FNV58_RS04680	COG2223	nitrite transmembrane transporter activity
FNV58_RS04710	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS04740	COG1609	Transcriptional regulator
FNV58_RS04755	COG0395	ABC-type sugar transport system, permease component
FNV58_RS04810	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FNV58_RS04830	COG0488	(ABC) transporter
FNV58_RS04835	COG0488	(ABC) transporter
FNV58_RS04890	COG1764	response to oxidative stress
FNV58_RS04930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV58_RS04960	COG0477	Major facilitator Superfamily
FNV58_RS05000	COG3345	alpha-galactosidase
FNV58_RS05020	COG2186	Transcriptional regulator
FNV58_RS05030	COG1175	transmembrane transport
FNV58_RS05035	COG0395	ABC-type sugar transport system, permease component
FNV58_RS05050	COG3618	amidohydrolase
FNV58_RS05055	COG1063	alcohol dehydrogenase
FNV58_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05065	COG0800	Aldolase
FNV58_RS05080	COG0179	Fumarylacetoacetate (FAA) hydrolase
FNV58_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05100	COG0247	lactate metabolic process
FNV58_RS05110	COG3693	PFAM glycoside hydrolase, family 10
FNV58_RS05140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS05150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS05155	COG0800	Aldolase
FNV58_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05165	COG1063	alcohol dehydrogenase
FNV58_RS05175	COG3618	amidohydrolase
FNV58_RS05180	COG4948	Mandelate Racemase Muconate Lactonizing
FNV58_RS05185	COG1172	Belongs to the binding-protein-dependent transport system permease family
FNV58_RS05190	COG1129	ABC transporter
FNV58_RS05205	COG2755	lipolytic protein G-D-S-L family
FNV58_RS05220	COG3507	Belongs to the glycosyl hydrolase 43 family
FNV58_RS05240	COG0395	ABC-type sugar transport system, permease component
FNV58_RS05245	COG4209	transmembrane transport
FNV58_RS05270	COG1501	Belongs to the glycosyl hydrolase 31 family
FNV58_RS05305	COG0519	Catalyzes the synthesis of GMP from XMP
FNV58_RS05305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FNV58_RS05320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV58_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05345	COG2188	Transcriptional regulator
FNV58_RS05355	COG1175	transmembrane transport
FNV58_RS05360	COG0395	ABC-type sugar transport system, permease component
FNV58_RS05430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV58_RS05440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FNV58_RS05480	COG3469	chitinase activity
FNV58_RS05495	COG3629	intracellular signal transduction
FNV58_RS05495	COG3903	Transcriptional regulator
FNV58_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05550	COG1764	response to oxidative stress
FNV58_RS05615	COG2770	Histidine kinase
FNV58_RS05615	COG2208	phosphoserine phosphatase activity
FNV58_RS05635	COG0583	DNA-binding transcription factor activity
FNV58_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS05675	COG0702	epimerase
FNV58_RS05685	COG2271	Major facilitator Superfamily
FNV58_RS05690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV58_RS05690	COG2755	lipolytic protein G-D-S-L family
FNV58_RS05695	COG3250	beta-galactosidase activity
FNV58_RS05730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FNV58_RS05775	COG2197	response regulator
FNV58_RS05790	COG1082	Xylose isomerase domain protein TIM barrel
FNV58_RS05800	COG1082	Xylose isomerase domain protein TIM barrel
FNV58_RS05820	COG2226	methyltransferase
FNV58_RS05825	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV58_RS05855	COG4213	ABC transporter substrate-binding protein
FNV58_RS05865	COG4213	ABC transporter substrate-binding protein
FNV58_RS05875	COG4214	carbohydrate transport
FNV58_RS05885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV58_RS05890	COG1414	Transcriptional regulator
FNV58_RS05915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FNV58_RS05920	COG0640	Transcriptional regulator
FNV58_RS05925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV58_RS05930	COG0248	Ppx GppA phosphatase
FNV58_RS05940	COG1609	Transcriptional regulator
FNV58_RS05960	COG0395	ABC-type sugar transport system, permease component
FNV58_RS05975	COG0477	Major facilitator Superfamily
FNV58_RS05985	COG2124	cytochrome p450
FNV58_RS06060	COG1191	sigma factor activity
FNV58_RS06065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FNV58_RS06150	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FNV58_RS06160	COG1064	alcohol dehydrogenase
FNV58_RS06190	COG0009	L-threonylcarbamoyladenylate synthase
FNV58_RS06200	COG0443	Heat shock 70 kDa protein
FNV58_RS06205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FNV58_RS06220	COG0542	response to heat
FNV58_RS06235	COG1414	Transcriptional regulator
FNV58_RS06240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV58_RS06245	COG2610	gluconate transmembrane transporter activity
FNV58_RS06250	COG4948	Mandelate Racemase Muconate Lactonizing
FNV58_RS06265	COG1136	(ABC) transporter
FNV58_RS06270	COG4585	Histidine kinase
FNV58_RS06275	COG2197	response regulator
FNV58_RS06280	COG1309	transcriptional regulator
FNV58_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS06295	COG1595	DNA-templated transcription, initiation
FNV58_RS06305	COG2362	D-Aminopeptidase
FNV58_RS06335	COG2814	Major facilitator Superfamily
FNV58_RS06350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FNV58_RS06355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV58_RS06360	COG2186	Transcriptional regulator
FNV58_RS06380	COG5006	permease, DMT superfamily
FNV58_RS06395	COG0477	Major facilitator Superfamily
FNV58_RS06450	COG0464	growth
FNV58_RS06555	COG1940	carbohydrate kinase activity
FNV58_RS06555	COG1846	Transcriptional regulator
FNV58_RS06635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV58_RS06655	COG4585	Histidine kinase
FNV58_RS06660	COG2197	response regulator
FNV58_RS06705	COG1881	PFAM PEBP family protein
FNV58_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS06725	COG2186	Transcriptional regulator
FNV58_RS06730	COG1024	Enoyl-CoA hydratase
FNV58_RS06735	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS06740	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS06745	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS06755	COG1024	Enoyl-CoA hydratase
FNV58_RS06760	COG0183	Belongs to the thiolase family
FNV58_RS06765	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS06785	COG1024	Enoyl-CoA hydratase
FNV58_RS06790	COG1024	Enoyl-CoA hydratase
FNV58_RS06840	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS06850	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS06855	COG2272	Belongs to the type-B carboxylesterase lipase family
FNV58_RS06860	COG1024	Enoyl-CoA hydratase
FNV58_RS06875	COG0183	Belongs to the thiolase family
FNV58_RS06880	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS06900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS06905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS06910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS06910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS06915	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS06925	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS06935	COG1024	Enoyl-CoA hydratase
FNV58_RS06945	COG1309	transcriptional regulator
FNV58_RS06985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS06990	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS07015	COG4638	Rieske (2fe-2S)
FNV58_RS07025	COG1228	amidohydrolase
FNV58_RS07035	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS07045	COG3321	synthase
FNV58_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS07045	COG0604	alcohol dehydrogenase
FNV58_RS07055	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS07090	COG0745	RESPONSE REGULATOR receiver
FNV58_RS07095	COG1846	Transcriptional regulator
FNV58_RS07100	COG1309	transcriptional regulator
FNV58_RS07105	COG4585	Histidine kinase
FNV58_RS07110	COG2197	response regulator
FNV58_RS07130	COG2814	Major facilitator Superfamily
FNV58_RS07180	COG0277	FAD linked oxidase domain protein
FNV58_RS07195	COG0366	Alpha amylase catalytic
FNV58_RS07205	COG3281	Trehalose synthase
FNV58_RS07210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FNV58_RS07240	COG0577	efflux transmembrane transporter activity
FNV58_RS07240	COG1136	(ABC) transporter
FNV58_RS07340	COG0477	Major facilitator Superfamily
FNV58_RS07365	COG0494	nUDIX hydrolase
FNV58_RS07395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FNV58_RS07450	COG0791	NLP P60 protein
FNV58_RS07450	COG3883	PFAM NLP P60 protein
FNV58_RS07495	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FNV58_RS07530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FNV58_RS07570	COG0539	negative regulation of cytoplasmic translation
FNV58_RS07585	COG4974	Belongs to the 'phage' integrase family
FNV58_RS07630	COG0531	amino acid
FNV58_RS07640	COG1181	Belongs to the D-alanine--D-alanine ligase family
FNV58_RS07660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FNV58_RS07730	COG3189	MarR family transcriptional regulator
FNV58_RS07795	COG0396	ATPase activity
FNV58_RS07850	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS07850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS07850	COG3321	synthase
FNV58_RS07850	COG4221	oxidoreductase activity
FNV58_RS07855	COG2175	clavaminate synthase activity
FNV58_RS07970	COG3903	Transcriptional regulator
FNV58_RS07970	COG3629	intracellular signal transduction
FNV58_RS08055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV58_RS08055	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV58_RS08270	COG2226	methyltransferase
FNV58_RS08410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV58_RS08415	COG1793	dna ligase
FNV58_RS08450	COG2826	transposase and inactivated derivatives, IS30 family
FNV58_RS08460	COG3903	Transcriptional regulator
FNV58_RS08460	COG3629	intracellular signal transduction
FNV58_RS08530	COG1278	Cold shock
FNV58_RS08580	COG1484	DNA-dependent DNA replication
FNV58_RS08585	COG4584	PFAM Integrase catalytic
FNV58_RS08645	COG3345	alpha-galactosidase
FNV58_RS08650	COG0395	ABC-type sugar transport system, permease component
FNV58_RS08655	COG1175	transmembrane transport
FNV58_RS08665	COG1940	carbohydrate kinase activity
FNV58_RS08665	COG1846	Transcriptional regulator
FNV58_RS08680	COG0574	Belongs to the PEP-utilizing enzyme family
FNV58_RS08680	COG3848	Pyruvate phosphate dikinase
FNV58_RS08740	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV58_RS08745	COG1793	dna ligase
FNV58_RS08755	COG0539	negative regulation of cytoplasmic translation
FNV58_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS08805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FNV58_RS08850	COG2267	carboxylic ester hydrolase activity
FNV58_RS08945	COG2226	methyltransferase
FNV58_RS09030	COG0702	epimerase
FNV58_RS09120	COG3547	Transposase (IS116 IS110 IS902 family)
FNV58_RS09295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FNV58_RS09325	COG1793	dna ligase
FNV58_RS09335	COG2826	transposase and inactivated derivatives, IS30 family
FNV58_RS09415	COG2801	Transposase and inactivated derivatives
FNV58_RS09465	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FNV58_RS09525	COG3387	PFAM Glycoside hydrolase 15-related
FNV58_RS09550	COG0492	ferredoxin-NADP+ reductase activity
FNV58_RS09570	COG2409	Drug exporters of the RND superfamily
FNV58_RS09575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV58_RS09585	COG2197	response regulator
FNV58_RS09625	COG3655	Transcriptional regulator
FNV58_RS09690	COG1335	isochorismatase
FNV58_RS09700	COG3328	transposase activity
FNV58_RS09775	COG0832	Belongs to the urease beta subunit family
FNV58_RS09775	COG0831	urea catabolic process
FNV58_RS09780	COG0804	urea catabolic process
FNV58_RS09785	COG0830	nickel cation binding
FNV58_RS09790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FNV58_RS09795	COG0829	nickel cation binding
FNV58_RS09805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FNV58_RS09825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV58_RS09875	COG1215	transferase activity, transferring glycosyl groups
FNV58_RS09890	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS09895	COG0789	Transcriptional regulator
FNV58_RS09900	COG4221	oxidoreductase activity
FNV58_RS09920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FNV58_RS09970	COG1618	nucleotide phosphatase activity, acting on free nucleotides
FNV58_RS10065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS10105	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FNV58_RS10155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FNV58_RS10260	COG2304	oxidoreductase activity
FNV58_RS10295	COG0328	RNA-DNA hybrid ribonuclease activity
FNV58_RS10350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV58_RS10360	COG0747	negative chemotaxis
FNV58_RS10390	COG3835	regulator
FNV58_RS10395	COG2010	Cytochrome c
FNV58_RS10395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV58_RS10400	COG2080	2 iron, 2 sulfur cluster binding
FNV58_RS10425	COG0009	L-threonylcarbamoyladenylate synthase
FNV58_RS10515	COG0596	Alpha beta hydrolase
FNV58_RS10520	COG0740	serine-type endopeptidase activity
FNV58_RS10525	COG0740	serine-type endopeptidase activity
FNV58_RS10535	COG2318	DinB family
FNV58_RS10550	COG0784	Response regulator, receiver
FNV58_RS10555	COG4251	negative regulation of phosphorylation
FNV58_RS10615	COG1716	ATPase activity
FNV58_RS10615	COG1131	(ABC) transporter
FNV58_RS10615	COG0842	Transport permease protein
FNV58_RS10635	COG2207	Transcriptional regulator
FNV58_RS10645	COG0667	Aldo Keto reductase
FNV58_RS10650	COG0583	DNA-binding transcription factor activity
FNV58_RS10665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV58_RS10670	COG0346	lactoylglutathione lyase activity
FNV58_RS10675	COG0671	phosphoesterase, PA-phosphatase related
FNV58_RS10685	COG0412	Dienelactone hydrolase
FNV58_RS10690	COG0667	Aldo Keto reductase
FNV58_RS10700	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS10705	COG4941	Belongs to the sigma-70 factor family
FNV58_RS10720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS10730	COG0431	NADPH-dependent FMN reductase
FNV58_RS10750	COG0702	epimerase
FNV58_RS10835	COG0531	amino acid
FNV58_RS10840	COG1940	carbohydrate kinase activity
FNV58_RS10845	COG3250	beta-galactosidase activity
FNV58_RS10865	COG3345	alpha-galactosidase
FNV58_RS10870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS10890	COG0667	Aldo Keto reductase
FNV58_RS10920	COG0367	asparagine synthase
FNV58_RS10925	COG0069	glutamate synthase activity
FNV58_RS10930	COG2235	arginine
FNV58_RS10945	COG0673	inositol 2-dehydrogenase activity
FNV58_RS10950	COG3511	phospholipase C
FNV58_RS10985	COG1404	Belongs to the peptidase S8 family
FNV58_RS11000	COG1672	PFAM Archaeal ATPase
FNV58_RS11000	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV58_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS11045	COG2366	antibiotic biosynthetic process
FNV58_RS11055	COG2070	2-Nitropropane dioxygenase
FNV58_RS11065	COG0515	serine threonine protein kinase
FNV58_RS11075	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS11100	COG4172	Belongs to the ABC transporter superfamily
FNV58_RS11105	COG4171	peptide transport system, permease
FNV58_RS11115	COG0747	negative chemotaxis
FNV58_RS11130	COG0019	diaminopimelate decarboxylase activity
FNV58_RS11135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FNV58_RS11140	COG0534	Mate efflux family protein
FNV58_RS11145	COG1609	Transcriptional regulator
FNV58_RS11160	COG2188	Transcriptional regulator
FNV58_RS11170	COG3962	Belongs to the TPP enzyme family
FNV58_RS11175	COG3718	enzyme involved in inositol metabolism
FNV58_RS11185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS11215	COG0028	Belongs to the TPP enzyme family
FNV58_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS11225	COG2072	flavoprotein involved in K transport
FNV58_RS11230	COG4638	Rieske (2fe-2S)
FNV58_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS11240	COG3386	PFAM SMP-30 Gluconolaconase
FNV58_RS11245	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS11250	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS11260	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS11265	COG0604	alcohol dehydrogenase
FNV58_RS11275	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS11280	COG0427	acetyl-CoA hydrolase
FNV58_RS11310	COG2186	Transcriptional regulator
FNV58_RS11315	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS11325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS11330	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS11355	COG3321	synthase
FNV58_RS11355	COG4221	oxidoreductase activity
FNV58_RS11355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS11355	COG0604	alcohol dehydrogenase
FNV58_RS11390	COG1309	transcriptional regulator
FNV58_RS11400	COG1335	isochorismatase
FNV58_RS11475	COG2072	flavoprotein involved in K transport
FNV58_RS11500	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FNV58_RS11505	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FNV58_RS11510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FNV58_RS11520	COG0531	amino acid
FNV58_RS11570	COG0604	alcohol dehydrogenase
FNV58_RS11570	COG3321	synthase
FNV58_RS11580	COG1073	alpha beta
FNV58_RS11625	COG0363	glucosamine-6-phosphate deaminase activity
FNV58_RS11630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FNV58_RS11650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FNV58_RS11655	COG2376	Dihydroxyacetone kinase
FNV58_RS11660	COG1461	Dihydroxyacetone kinase
FNV58_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS11705	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV58_RS11705	COG1902	pentaerythritol trinitrate reductase activity
FNV58_RS11710	COG2890	protein-(glutamine-N5) methyltransferase activity
FNV58_RS11725	COG3321	synthase
FNV58_RS11725	COG0604	alcohol dehydrogenase
FNV58_RS11730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FNV58_RS11755	COG3458	cephalosporin-C deacetylase activity
FNV58_RS11765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV58_RS11770	COG2188	Transcriptional regulator
FNV58_RS11780	COG2226	methyltransferase
FNV58_RS11785	COG0366	Alpha amylase catalytic
FNV58_RS11790	COG2267	carboxylic ester hydrolase activity
FNV58_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS11805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FNV58_RS11845	COG0179	Fumarylacetoacetate (FAA) hydrolase
FNV58_RS11860	COG4941	Belongs to the sigma-70 factor family
FNV58_RS11870	COG3795	YCII-related domain
FNV58_RS11880	COG0346	lactoylglutathione lyase activity
FNV58_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS11895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FNV58_RS11900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FNV58_RS11905	COG1686	Belongs to the peptidase S11 family
FNV58_RS11910	COG5650	phosphatidylinositol metabolic process
FNV58_RS11920	COG2066	Belongs to the glutaminase family
FNV58_RS11935	COG1113	amino acid transport
FNV58_RS11945	COG1968	undecaprenyl-diphosphatase activity
FNV58_RS11950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FNV58_RS11955	COG1993	acr, cog1993
FNV58_RS11960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FNV58_RS11985	COG1175	transmembrane transport
FNV58_RS11990	COG0395	ABC-type sugar transport system, permease component
FNV58_RS12015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FNV58_RS12030	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS12040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV58_RS12080	COG1215	transferase activity, transferring glycosyl groups
FNV58_RS12095	COG0633	Ferredoxin
FNV58_RS12095	COG3217	Mosc domain protein beta barrel domain protein
FNV58_RS12115	COG1349	DNA-binding transcription factor activity
FNV58_RS12140	COG0577	efflux transmembrane transporter activity
FNV58_RS12145	COG1136	(ABC) transporter
FNV58_RS12170	COG1940	carbohydrate kinase activity
FNV58_RS12180	COG2813	Specifically methylates the guanine in position
FNV58_RS12205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV58_RS12210	COG1349	DNA-binding transcription factor activity
FNV58_RS12215	COG3537	Alpha-1,2-mannosidase
FNV58_RS12225	COG1174	glycine betaine transport
FNV58_RS12245	COG2018	Roadblock/LC7 domain
FNV58_RS12275	COG3320	Male sterility
FNV58_RS12275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS12280	COG0604	alcohol dehydrogenase
FNV58_RS12280	COG3321	synthase
FNV58_RS12285	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS12295	COG0596	Alpha beta hydrolase
FNV58_RS12300	COG4565	transcriptional regulatory protein
FNV58_RS12305	COG3290	protein histidine kinase activity
FNV58_RS12315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS12350	COG1271	oxidase subunit
FNV58_RS12405	COG3387	PFAM Glycoside hydrolase 15-related
FNV58_RS12425	COG2223	nitrite transmembrane transporter activity
FNV58_RS12450	COG2197	response regulator
FNV58_RS12455	COG4585	Histidine kinase
FNV58_RS12470	COG0445	tRNA wobble uridine modification
FNV58_RS12480	COG1660	Displays ATPase and GTPase activities
FNV58_RS12510	COG0395	ABC-type sugar transport system, permease component
FNV58_RS12525	COG3345	alpha-galactosidase
FNV58_RS12555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FNV58_RS12580	COG0204	Acyl-transferase
FNV58_RS12610	COG0584	glycerophosphoryl diester phosphodiesterase
FNV58_RS12670	COG1309	transcriptional regulator
FNV58_RS12695	COG0640	Transcriptional regulator
FNV58_RS12700	COG1902	pentaerythritol trinitrate reductase activity
FNV58_RS12715	COG2197	response regulator
FNV58_RS12720	COG4585	Histidine kinase
FNV58_RS12725	COG3963	phosphatidate phosphatase activity
FNV58_RS12750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV58_RS12750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV58_RS12790	COG0714	Associated with various cellular activities
FNV58_RS12795	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FNV58_RS12825	COG0596	Alpha beta hydrolase
FNV58_RS12830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FNV58_RS12830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FNV58_RS12835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FNV58_RS12845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FNV58_RS12860	COG2706	6-phosphogluconolactonase activity
FNV58_RS12865	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
FNV58_RS12900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV58_RS12905	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FNV58_RS12910	COG2080	2 iron, 2 sulfur cluster binding
FNV58_RS12920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FNV58_RS12935	COG2770	Histidine kinase
FNV58_RS12935	COG2208	phosphoserine phosphatase activity
FNV58_RS12955	COG0745	RESPONSE REGULATOR receiver
FNV58_RS12990	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS13055	COG1733	regulation of RNA biosynthetic process
FNV58_RS13080	COG0667	Aldo Keto reductase
FNV58_RS13085	COG4221	oxidoreductase activity
FNV58_RS13105	COG0513	Belongs to the DEAD box helicase family
FNV58_RS13115	COG0432	Pfam Uncharacterised protein family UPF0047
FNV58_RS13120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS13125	COG1116	anion transmembrane transporter activity
FNV58_RS13135	COG2072	flavoprotein involved in K transport
FNV58_RS13145	COG1132	(ABC) transporter
FNV58_RS13155	COG1301	dicarboxylic acid transport
FNV58_RS13175	COG1132	(ABC) transporter
FNV58_RS13185	COG0254	rRNA binding
FNV58_RS13200	COG1946	Acyl-CoA thioesterase
FNV58_RS13210	COG2018	Roadblock/LC7 domain
FNV58_RS13275	COG3239	Fatty acid desaturase
FNV58_RS13280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FNV58_RS13300	COG2115	Belongs to the xylose isomerase family
FNV58_RS13310	COG1846	Transcriptional regulator
FNV58_RS13310	COG1940	carbohydrate kinase activity
FNV58_RS13315	COG1113	amino acid transport
FNV58_RS13335	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS13375	COG0515	serine threonine protein kinase
FNV58_RS13400	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS13405	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS13420	COG0492	ferredoxin-NADP+ reductase activity
FNV58_RS13425	COG1793	dna ligase
FNV58_RS13435	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS13450	COG3424	synthase
FNV58_RS13455	COG2124	cytochrome p450
FNV58_RS13465	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS13475	COG0242	peptide deformylase activity
FNV58_RS13485	COG3442	glutamine amidotransferase
FNV58_RS13490	COG0205	6-phosphofructokinase activity
FNV58_RS13505	COG2815	serine threonine protein kinase
FNV58_RS13505	COG0515	serine threonine protein kinase
FNV58_RS13510	COG3275	phosphorelay sensor kinase activity
FNV58_RS13515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV58_RS13525	COG3279	Response regulator of the LytR AlgR family
FNV58_RS13535	COG1834	amidinotransferase
FNV58_RS13540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FNV58_RS13550	COG1510	regulation of RNA biosynthetic process
FNV58_RS13585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FNV58_RS13610	COG0829	nickel cation binding
FNV58_RS13615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FNV58_RS13625	COG0804	urea catabolic process
FNV58_RS13630	COG0832	Belongs to the urease beta subunit family
FNV58_RS13635	COG0831	urea catabolic process
FNV58_RS13645	COG0740	serine-type endopeptidase activity
FNV58_RS13685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FNV58_RS13690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FNV58_RS13695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FNV58_RS13705	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FNV58_RS13710	COG2226	methyltransferase
FNV58_RS13785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FNV58_RS13795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FNV58_RS13800	COG3663	DNA glycosylase
FNV58_RS13820	COG4585	Histidine kinase
FNV58_RS13825	COG2197	response regulator
FNV58_RS13830	COG1940	carbohydrate kinase activity
FNV58_RS13835	COG2188	Transcriptional regulator
FNV58_RS13840	COG1595	DNA-templated transcription, initiation
FNV58_RS13855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS13870	COG0626	cystathionine gamma-synthase activity
FNV58_RS13890	COG0583	DNA-binding transcription factor activity
FNV58_RS13900	COG1522	sequence-specific DNA binding
FNV58_RS13905	COG0419	ATPase involved in DNA repair
FNV58_RS13910	COG0420	3'-5' exonuclease activity
FNV58_RS13915	COG1739	Uncharacterized protein family UPF0029
FNV58_RS13935	COG2197	response regulator
FNV58_RS13945	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS13960	COG1832	CoA-binding protein
FNV58_RS13970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV58_RS13975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FNV58_RS14000	COG2326	polyphosphate kinase activity
FNV58_RS14030	COG0110	maltose O-acetyltransferase activity
FNV58_RS14050	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV58_RS14065	COG1609	Transcriptional regulator
FNV58_RS14105	COG0076	glutamate decarboxylase activity
FNV58_RS14130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FNV58_RS14145	COG0183	Belongs to the thiolase family
FNV58_RS14170	COG1968	undecaprenyl-diphosphatase activity
FNV58_RS14195	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS14215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS14225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FNV58_RS14235	COG2318	DinB family
FNV58_RS14250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FNV58_RS14255	COG0747	negative chemotaxis
FNV58_RS14290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FNV58_RS14300	COG1760	l-serine dehydratase
FNV58_RS14305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV58_RS14310	COG0509	glycine decarboxylation via glycine cleavage system
FNV58_RS14350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FNV58_RS14370	COG0517	IMP dehydrogenase activity
FNV58_RS14370	COG4175	Glycine betaine
FNV58_RS14375	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS14395	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FNV58_RS14405	COG4638	Rieske (2fe-2S)
FNV58_RS14410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FNV58_RS14420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS14460	COG0697	spore germination
FNV58_RS14535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FNV58_RS14535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FNV58_RS14545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FNV58_RS14565	COG1716	ATPase activity
FNV58_RS14585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FNV58_RS14620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FNV58_RS14635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS14640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV58_RS14650	COG2816	NAD+ diphosphatase activity
FNV58_RS14655	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FNV58_RS14665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV58_RS14670	COG3706	GGDEF domain
FNV58_RS14675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV58_RS14680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV58_RS14700	COG2018	Roadblock/LC7 domain
FNV58_RS14750	COG2814	Major facilitator Superfamily
FNV58_RS14755	COG4336	lyase activity
FNV58_RS14760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FNV58_RS14765	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FNV58_RS14770	COG1984	allophanate hydrolase subunit 2
FNV58_RS14775	COG2755	lipolytic protein G-D-S-L family
FNV58_RS14780	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS14785	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS14810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS14825	COG2270	Major facilitator Superfamily
FNV58_RS14840	COG0463	Glycosyl transferase, family 2
FNV58_RS14875	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS14885	COG1309	transcriptional regulator
FNV58_RS14930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FNV58_RS14935	COG0140	phosphoribosyl-ATP diphosphatase activity
FNV58_RS14940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FNV58_RS14945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV58_RS14945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV58_RS14950	COG3201	nicotinamide mononucleotide transporter
FNV58_RS14960	COG1940	carbohydrate kinase activity
FNV58_RS14960	COG1846	Transcriptional regulator
FNV58_RS14965	COG2223	nitrite transmembrane transporter activity
FNV58_RS14980	COG2233	PERMEase
FNV58_RS15005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FNV58_RS15025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FNV58_RS15030	COG3842	ATPase activity
FNV58_RS15040	COG1176	ABC-type spermidine putrescine transport system, permease component I
FNV58_RS15050	COG2188	Transcriptional regulator
FNV58_RS15060	COG0531	amino acid
FNV58_RS15080	COG2390	Transcriptional regulator
FNV58_RS15085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FNV58_RS15095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FNV58_RS15115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FNV58_RS15130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FNV58_RS15145	COG0194	GDP metabolic process
FNV58_RS15155	COG0284	orotidine-5'-phosphate decarboxylase activity
FNV58_RS15160	COG0167	dihydroorotate dehydrogenase activity
FNV58_RS15165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FNV58_RS15170	COG0505	Belongs to the CarA family
FNV58_RS15180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FNV58_RS15185	COG0540	Belongs to the ATCase OTCase family
FNV58_RS15190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FNV58_RS15200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FNV58_RS15205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FNV58_RS15210	COG0006	proline dipeptidase activity
FNV58_RS15220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FNV58_RS15225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FNV58_RS15230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FNV58_RS15235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FNV58_RS15240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FNV58_RS15250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FNV58_RS15255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FNV58_RS15275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FNV58_RS15290	COG1131	(ABC) transporter
FNV58_RS15300	COG4585	Histidine kinase
FNV58_RS15305	COG2197	response regulator
FNV58_RS15310	COG0124	histidyl-tRNA synthetase
FNV58_RS15320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FNV58_RS15325	COG1196	nuclear chromosome segregation
FNV58_RS15330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FNV58_RS15340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FNV58_RS15345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FNV58_RS15350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FNV58_RS15360	COG2255	four-way junction helicase activity
FNV58_RS15365	COG0632	four-way junction helicase activity
FNV58_RS15370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FNV58_RS15375	COG0217	transcriptional regulatory protein
FNV58_RS15380	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FNV58_RS15385	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FNV58_RS15405	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS15415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FNV58_RS15435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FNV58_RS15440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FNV58_RS15455	COG5002	protein histidine kinase activity
FNV58_RS15455	COG2176	DNA-directed DNA polymerase activity
FNV58_RS15485	COG0395	ABC-type sugar transport system, permease component
FNV58_RS15490	COG1175	transmembrane transport
FNV58_RS15540	COG0512	Glutamine amidotransferase of anthranilate synthase
FNV58_RS15540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FNV58_RS15600	COG1648	precorrin-2 dehydrogenase activity
FNV58_RS15600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FNV58_RS15605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FNV58_RS15620	COG1464	Belongs to the NlpA lipoprotein family
FNV58_RS15625	COG2011	ABC-type metal ion transport system permease component
FNV58_RS15630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FNV58_RS15665	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS15665	COG0204	Acyl-transferase
FNV58_RS15670	COG0477	Major facilitator Superfamily
FNV58_RS15685	COG0165	Argininosuccinate lyase
FNV58_RS15690	COG0137	argininosuccinate synthase activity
FNV58_RS15710	COG2205	protein histidine kinase activity
FNV58_RS15715	COG0745	RESPONSE REGULATOR receiver
FNV58_RS15745	COG1438	arginine binding
FNV58_RS15750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FNV58_RS15755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FNV58_RS15760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FNV58_RS15765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FNV58_RS15785	COG0789	Transcriptional regulator
FNV58_RS15820	COG0697	spore germination
FNV58_RS15830	COG1649	PFAM Uncharacterised BCR, COG1649
FNV58_RS15860	COG0072	phenylalanine-tRNA ligase activity
FNV58_RS15860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNV58_RS15865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FNV58_RS15870	COG5002	protein histidine kinase activity
FNV58_RS15875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FNV58_RS15880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FNV58_RS15885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FNV58_RS15890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FNV58_RS15945	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS15950	COG0174	glutamine synthetase
FNV58_RS15960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FNV58_RS16000	COG4176	ABC-type proline glycine betaine transport system permease component
FNV58_RS16005	COG0517	IMP dehydrogenase activity
FNV58_RS16005	COG4175	Glycine betaine
FNV58_RS16010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV58_RS16040	COG0564	pseudouridine synthase activity
FNV58_RS16070	COG1309	transcriptional regulator
FNV58_RS16110	COG0805	protein transport
FNV58_RS16115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV58_RS16145	COG0545	Peptidyl-prolyl cis-trans isomerase
FNV58_RS16150	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FNV58_RS16160	COG1609	Transcriptional regulator
FNV58_RS16165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FNV58_RS16170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FNV58_RS16185	COG4122	O-methyltransferase activity
FNV58_RS16190	COG1222	aaa ATPase
FNV58_RS16215	COG1994	Peptidase M50
FNV58_RS16215	COG0517	IMP dehydrogenase activity
FNV58_RS16225	COG2197	response regulator
FNV58_RS16235	COG4166	transmembrane transport
FNV58_RS16245	COG0646	methionine synthase
FNV58_RS16245	COG1410	methionine synthase
FNV58_RS16250	COG1414	Transcriptional regulator
FNV58_RS16255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV58_RS16260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV58_RS16265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FNV58_RS16270	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
FNV58_RS16280	COG1129	ABC transporter
FNV58_RS16290	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FNV58_RS16295	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FNV58_RS16300	COG0235	Class ii aldolase
FNV58_RS16305	COG0235	Class ii aldolase
FNV58_RS16305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FNV58_RS16310	COG2186	Transcriptional regulator
FNV58_RS16335	COG0215	cysteine-tRNA ligase activity
FNV58_RS16355	COG0598	Magnesium transport protein CorA
FNV58_RS16365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS16370	COG0667	Aldo Keto reductase
FNV58_RS16400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV58_RS16415	COG0308	aminopeptidase N
FNV58_RS16420	COG3012	SEC-C Motif Domain Protein
FNV58_RS16425	COG2186	Transcriptional regulator
FNV58_RS16430	COG3265	gluconokinase activity
FNV58_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS16445	COG1063	alcohol dehydrogenase
FNV58_RS16470	COG3573	Dehydrogenase
FNV58_RS16480	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FNV58_RS16485	COG2149	membrane
FNV58_RS16515	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS16525	COG3876	Protein conserved in bacteria
FNV58_RS16545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNV58_RS16545	COG0072	phenylalanine-tRNA ligase activity
FNV58_RS16550	COG0789	Transcriptional regulator
FNV58_RS16570	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS16580	COG0640	Transcriptional regulator
FNV58_RS16585	COG0697	spore germination
FNV58_RS16610	COG2851	Citrate transporter
FNV58_RS16615	COG0243	molybdopterin cofactor binding
FNV58_RS16620	COG1309	transcriptional regulator
FNV58_RS16630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FNV58_RS16635	COG2188	Transcriptional regulator
FNV58_RS16670	COG1595	DNA-templated transcription, initiation
FNV58_RS16690	COG0515	serine threonine protein kinase
FNV58_RS16690	COG2815	serine threonine protein kinase
FNV58_RS16695	COG2755	lipolytic protein G-D-S-L family
FNV58_RS16715	COG1649	PFAM Uncharacterised BCR, COG1649
FNV58_RS16715	COG0726	polysaccharide deacetylase
FNV58_RS16740	COG1725	Transcriptional regulator
FNV58_RS16780	COG0662	Cupin 2, conserved barrel domain protein
FNV58_RS16780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FNV58_RS16785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FNV58_RS16790	COG0587	DNA-directed DNA polymerase activity
FNV58_RS16800	COG0330	HflC and HflK could
FNV58_RS16815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS16820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS16825	COG1126	abc transporter atp-binding protein
FNV58_RS16835	COG0765	amino acid transport
FNV58_RS16840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV58_RS16850	COG1799	cell septum assembly
FNV58_RS16855	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS16860	COG0477	Major facilitator Superfamily
FNV58_RS16870	COG0671	phosphoesterase, PA-phosphatase related
FNV58_RS16880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FNV58_RS16910	COG1129	ABC transporter
FNV58_RS16940	COG1160	GTP binding
FNV58_RS16950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FNV58_RS16990	COG3541	Predicted nucleotidyltransferase
FNV58_RS17005	COG1187	pseudouridine synthase activity
FNV58_RS17010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FNV58_RS17015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FNV58_RS17030	COG0686	Belongs to the AlaDH PNT family
FNV58_RS17040	COG0494	nUDIX hydrolase
FNV58_RS17045	COG0504	CTP synthase activity
FNV58_RS17050	COG3387	PFAM Glycoside hydrolase 15-related
FNV58_RS17075	COG0497	DNA recombination
FNV58_RS17080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FNV58_RS17100	COG1120	ATPase activity
FNV58_RS17105	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV58_RS17110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV58_RS17115	COG0647	UMP catabolic process
FNV58_RS17155	COG2094	Belongs to the DNA glycosylase MPG family
FNV58_RS17165	COG1881	PFAM PEBP family protein
FNV58_RS17185	COG1119	ATPase activity
FNV58_RS17210	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS17215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FNV58_RS17225	COG1716	ATPase activity
FNV58_RS17225	COG0842	Transport permease protein
FNV58_RS17225	COG1131	(ABC) transporter
FNV58_RS17235	COG3830	Belongs to the UPF0237 family
FNV58_RS17235	COG0560	Phosphoserine phosphatase
FNV58_RS17240	COG0588	phosphoglycerate mutase activity
FNV58_RS17255	COG2186	Transcriptional regulator
FNV58_RS17265	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FNV58_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS17285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FNV58_RS17305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FNV58_RS17310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV58_RS17330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS17380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FNV58_RS17395	COG3387	PFAM Glycoside hydrolase 15-related
FNV58_RS17445	COG0488	(ABC) transporter
FNV58_RS17475	COG0235	Class ii aldolase
FNV58_RS17495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FNV58_RS17500	COG1492	cobalamin metabolic process
FNV58_RS17515	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FNV58_RS17520	COG1797	cobyrinic acid a,c-diamide synthase activity
FNV58_RS17585	COG0765	amino acid transport
FNV58_RS17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV58_RS17595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FNV58_RS17600	COG0456	acetyltransferase
FNV58_RS17605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FNV58_RS17610	COG1917	Cupin 2, conserved barrel domain protein
FNV58_RS17615	COG5285	phytanoyl-CoA dioxygenase
FNV58_RS17620	COG3844	kynureninase activity
FNV58_RS17645	COG1414	Transcriptional regulator
FNV58_RS17655	COG0768	penicillin binding
FNV58_RS17660	COG2252	PERMEase
FNV58_RS17665	COG1595	DNA-templated transcription, initiation
FNV58_RS17680	COG4733	cellulase activity
FNV58_RS17720	COG4677	pectinesterase activity
FNV58_RS17725	COG3866	Pectate lyase
FNV58_RS17730	COG2755	lipolytic protein G-D-S-L family
FNV58_RS17735	COG1653	transport
FNV58_RS17755	COG0395	ABC-type sugar transport system, permease component
FNV58_RS17770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV58_RS17775	COG1802	Transcriptional regulator
FNV58_RS17800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV58_RS17805	COG1349	DNA-binding transcription factor activity
FNV58_RS17820	COG0395	ABC-type sugar transport system, permease component
FNV58_RS17825	COG1063	alcohol dehydrogenase
FNV58_RS17835	COG1309	transcriptional regulator
FNV58_RS17850	COG1802	Transcriptional regulator
FNV58_RS17890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV58_RS17905	COG3973	AAA domain
FNV58_RS17920	COG2171	N-acyltransferase activity
FNV58_RS17925	COG3226	Transcriptional regulator
FNV58_RS17930	COG2076	Multidrug Resistance protein
FNV58_RS17945	COG2151	metal-sulfur cluster biosynthetic enzyme
FNV58_RS17950	COG0822	iron-sulfur transferase activity
FNV58_RS17955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FNV58_RS17960	COG0396	ATPase activity
FNV58_RS17970	COG0719	Fe-S assembly protein
FNV58_RS17985	COG2746	aminoglycoside 3-N-acetyltransferase activity
FNV58_RS17990	COG1131	(ABC) transporter
FNV58_RS18015	COG0109	protoheme IX farnesyltransferase activity
FNV58_RS18030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FNV58_RS18045	COG0363	glucosamine-6-phosphate deaminase activity
FNV58_RS18050	COG0395	ABC-type sugar transport system, permease component
FNV58_RS18055	COG1175	transmembrane transport
FNV58_RS18065	COG0366	Alpha amylase catalytic
FNV58_RS18070	COG1653	transport
FNV58_RS18075	COG1695	Transcriptional regulator
FNV58_RS18080	COG1136	(ABC) transporter
FNV58_RS18095	COG0166	Belongs to the GPI family
FNV58_RS18110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FNV58_RS18115	COG0149	triose-phosphate isomerase activity
FNV58_RS18120	COG0126	phosphoglycerate kinase activity
FNV58_RS18125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FNV58_RS18135	COG1481	regulation of sporulation
FNV58_RS18140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FNV58_RS18145	COG1660	Displays ATPase and GTPase activities
FNV58_RS18150	COG0322	excinuclease ABC activity
FNV58_RS18165	COG1609	Transcriptional regulator
FNV58_RS18175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FNV58_RS18190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV58_RS18195	COG0765	amino acid transport
FNV58_RS18205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FNV58_RS18210	COG0477	Major facilitator Superfamily
FNV58_RS18215	COG0387	Pfam Sodium calcium exchanger
FNV58_RS18235	COG0556	nucleotide-excision repair
FNV58_RS18245	COG0584	glycerophosphoryl diester phosphodiesterase
FNV58_RS18250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FNV58_RS18270	COG2313	pseudouridylate synthase activity
FNV58_RS18280	COG2226	methyltransferase
FNV58_RS18285	COG0598	Magnesium transport protein CorA
FNV58_RS18315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS18320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS18360	COG0402	S-adenosylhomocysteine deaminase activity
FNV58_RS18385	COG1201	RNA secondary structure unwinding
FNV58_RS18435	COG2856	Zn peptidase
FNV58_RS18500	COG1953	Uracil, thiamine, allantoin
FNV58_RS18505	COG1802	Transcriptional regulator
FNV58_RS18510	COG2267	carboxylic ester hydrolase activity
FNV58_RS18520	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FNV58_RS18550	COG0237	dephospho-CoA kinase activity
FNV58_RS18570	COG2226	methyltransferase
FNV58_RS18575	COG1643	Atp-dependent helicase
FNV58_RS18615	COG2050	protein possibly involved in aromatic compounds catabolism
FNV58_RS18675	COG0737	Belongs to the 5'-nucleotidase family
FNV58_RS18695	COG4566	intracellular signal transduction
FNV58_RS18700	COG0287	Prephenate dehydrogenase
FNV58_RS18700	COG1605	Chorismate mutase
FNV58_RS18735	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS18745	COG1024	Enoyl-CoA hydratase
FNV58_RS18770	COG0183	Belongs to the thiolase family
FNV58_RS18775	COG1309	transcriptional regulator
FNV58_RS18785	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS18790	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS18795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV58_RS18805	COG2304	oxidoreductase activity
FNV58_RS18820	COG4591	ABC-type transport system involved in lipoprotein release permease component
FNV58_RS18820	COG1136	(ABC) transporter
FNV58_RS18835	COG0577	efflux transmembrane transporter activity
FNV58_RS18835	COG1136	(ABC) transporter
FNV58_RS18845	COG0069	glutamate synthase activity
FNV58_RS18845	COG0070	glutamate synthase
FNV58_RS18845	COG0067	glutamate synthase
FNV58_RS18875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS18880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS18885	COG2301	Belongs to the HpcH HpaI aldolase family
FNV58_RS18890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FNV58_RS18900	COG0159	tryptophan synthase activity
FNV58_RS18905	COG0133	tryptophan synthase activity
FNV58_RS18915	COG0134	indole-3-glycerol-phosphate synthase activity
FNV58_RS18940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FNV58_RS18960	COG0107	imidazoleglycerol-phosphate synthase activity
FNV58_RS18965	COG0251	oxidation-reduction process
FNV58_RS18970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FNV58_RS18975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FNV58_RS18980	COG0131	Imidazoleglycerol-phosphate dehydratase
FNV58_RS18985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV58_RS18990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FNV58_RS19010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FNV58_RS19030	COG1432	Conserved Protein
FNV58_RS19035	COG0587	DNA-directed DNA polymerase activity
FNV58_RS19095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FNV58_RS19110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FNV58_RS19115	COG3599	regulation of cell shape
FNV58_RS19125	COG1799	cell septum assembly
FNV58_RS19135	COG1496	oxidoreductase activity
FNV58_RS19140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FNV58_RS19155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FNV58_RS19165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FNV58_RS19170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNV58_RS19180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FNV58_RS19185	COG0768	penicillin binding
FNV58_RS19195	COG0275	rRNA processing
FNV58_RS19205	COG0714	Associated with various cellular activities
FNV58_RS19225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FNV58_RS19235	COG1126	abc transporter atp-binding protein
FNV58_RS19245	COG1309	transcriptional regulator
FNV58_RS19270	COG0352	thiamine-phosphate diphosphorylase activity
FNV58_RS19290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV58_RS19290	COG2022	thiamine diphosphate biosynthetic process
FNV58_RS19300	COG2022	thiamine diphosphate biosynthetic process
FNV58_RS19305	COG0515	serine threonine protein kinase
FNV58_RS19305	COG2815	serine threonine protein kinase
FNV58_RS19310	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FNV58_RS19315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FNV58_RS19320	COG2193	ferroxidase activity
FNV58_RS19325	COG0243	molybdopterin cofactor binding
FNV58_RS19330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FNV58_RS19350	COG0205	6-phosphofructokinase activity
FNV58_RS19360	COG4585	Histidine kinase
FNV58_RS19385	COG1940	carbohydrate kinase activity
FNV58_RS19395	COG0003	Pfam Anion-transporting ATPase
FNV58_RS19435	COG0534	Mate efflux family protein
FNV58_RS19455	COG1388	LysM domain
FNV58_RS19455	COG3103	Sh3 type 3 domain protein
FNV58_RS19455	COG0791	NLP P60 protein
FNV58_RS19480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FNV58_RS19485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FNV58_RS19490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV58_RS19495	COG0723	plastoquinol--plastocyanin reductase activity
FNV58_RS19500	COG2010	Cytochrome c
FNV58_RS19505	COG1845	cytochrome c oxidase, subunit III
FNV58_RS19515	COG1376	ErfK ybiS ycfS ynhG family protein
FNV58_RS19525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FNV58_RS19530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FNV58_RS19540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS19565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FNV58_RS19570	COG2197	response regulator
FNV58_RS19595	COG2226	methyltransferase
FNV58_RS19600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FNV58_RS19620	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FNV58_RS19625	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV58_RS19625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV58_RS19640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FNV58_RS19645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FNV58_RS19650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FNV58_RS19655	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV58_RS19670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FNV58_RS19700	COG0454	-acetyltransferase
FNV58_RS19720	COG0321	lipoyl(octanoyl) transferase activity
FNV58_RS19725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FNV58_RS19745	COG0174	glutamine synthetase
FNV58_RS19755	COG0501	Belongs to the peptidase M48B family
FNV58_RS19805	COG0745	RESPONSE REGULATOR receiver
FNV58_RS19820	COG2197	response regulator
FNV58_RS19850	COG1309	transcriptional regulator
FNV58_RS19885	COG1175	transmembrane transport
FNV58_RS19890	COG3833	ABC-type maltose transport systems, permease component
FNV58_RS19895	COG0366	Alpha amylase catalytic
FNV58_RS19900	COG1609	Transcriptional regulator
FNV58_RS19910	COG0583	DNA-binding transcription factor activity
FNV58_RS19915	COG0697	spore germination
FNV58_RS19920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FNV58_RS19925	COG3511	phospholipase C
FNV58_RS19965	COG0174	glutamine synthetase
FNV58_RS19970	COG1017	nitric oxide dioxygenase activity
FNV58_RS19970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FNV58_RS19975	COG1959	2 iron, 2 sulfur cluster binding
FNV58_RS19995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FNV58_RS19995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FNV58_RS20000	COG2814	Major facilitator Superfamily
FNV58_RS20015	COG0477	Major facilitator Superfamily
FNV58_RS20020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FNV58_RS20040	COG1994	Peptidase M50
FNV58_RS20100	COG2822	iron ion transport
FNV58_RS20105	COG2837	iron assimilation
FNV58_RS20110	COG0672	)-iron permease
FNV58_RS20120	COG0495	leucyl-tRNA aminoacylation
FNV58_RS20130	COG1834	amidinotransferase
FNV58_RS20140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV58_RS20145	COG2814	Major facilitator Superfamily
FNV58_RS20160	COG1686	Belongs to the peptidase S11 family
FNV58_RS20170	COG1136	(ABC) transporter
FNV58_RS20175	COG0667	Aldo Keto reductase
FNV58_RS20185	COG2259	Doxx family
FNV58_RS20200	COG0406	alpha-ribazole phosphatase activity
FNV58_RS20210	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS20215	COG0673	inositol 2-dehydrogenase activity
FNV58_RS20225	COG0583	DNA-binding transcription factor activity
FNV58_RS20250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FNV58_RS20280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FNV58_RS20355	COG3022	response to hydroperoxide
FNV58_RS20360	COG0800	Aldolase
FNV58_RS20385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FNV58_RS20400	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS20410	COG2030	dehydratase
FNV58_RS20415	COG1131	(ABC) transporter
FNV58_RS20425	COG4585	Histidine kinase
FNV58_RS20435	COG2197	response regulator
FNV58_RS20455	COG0183	Belongs to the thiolase family
FNV58_RS20460	COG0477	Major facilitator Superfamily
FNV58_RS20480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS20515	COG1309	transcriptional regulator
FNV58_RS20575	COG3845	ABC transporter
FNV58_RS20595	COG3619	membrane
FNV58_RS20620	COG0183	Belongs to the thiolase family
FNV58_RS20625	COG2124	cytochrome p450
FNV58_RS20645	COG4122	O-methyltransferase activity
FNV58_RS20725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FNV58_RS20730	COG1335	isochorismatase
FNV58_RS20735	COG0477	Major facilitator Superfamily
FNV58_RS20755	COG1733	regulation of RNA biosynthetic process
FNV58_RS20860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV58_RS20875	COG1358	cellular component organization or biogenesis
FNV58_RS20925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FNV58_RS20930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV58_RS20935	COG0477	Major facilitator Superfamily
FNV58_RS20940	COG1309	transcriptional regulator
FNV58_RS20955	COG0667	Aldo Keto reductase
FNV58_RS20960	COG0789	Transcriptional regulator
FNV58_RS20975	COG1741	Belongs to the pirin family
FNV58_RS20990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV58_RS20995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS21000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS21030	COG1309	transcriptional regulator
FNV58_RS21045	COG2084	Dehydrogenase
FNV58_RS21080	COG1764	response to oxidative stress
FNV58_RS21085	COG2130	NADP-dependent
FNV58_RS21100	COG4948	Mandelate Racemase Muconate Lactonizing
FNV58_RS21115	COG4213	ABC transporter substrate-binding protein
FNV58_RS21125	COG4214	carbohydrate transport
FNV58_RS21135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV58_RS21170	COG1764	response to oxidative stress
FNV58_RS21200	COG0596	Alpha beta hydrolase
FNV58_RS21220	COG2318	DinB family
FNV58_RS21245	COG3507	Belongs to the glycosyl hydrolase 43 family
FNV58_RS21250	COG0395	ABC-type sugar transport system, permease component
FNV58_RS21255	COG1175	transmembrane transport
FNV58_RS21265	COG3386	PFAM SMP-30 Gluconolaconase
FNV58_RS21270	COG1414	Transcriptional regulator
FNV58_RS21295	COG4981	capsule polysaccharide biosynthetic process
FNV58_RS21370	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS21375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FNV58_RS21375	COG0825	malonyl-CoA metabolic process
FNV58_RS21380	COG1404	Belongs to the peptidase S8 family
FNV58_RS21385	COG1077	Cell shape determining protein MreB Mrl
FNV58_RS21430	COG0559	Belongs to the binding-protein-dependent transport system permease family
FNV58_RS21450	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS21485	COG1070	Carbohydrate kinase
FNV58_RS21500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FNV58_RS21505	COG0358	DNA primase activity
FNV58_RS21515	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FNV58_RS21525	COG2949	membrane
FNV58_RS21590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FNV58_RS21590	COG2146	nitrite reductase [NAD(P)H] activity
FNV58_RS21600	COG1309	transcriptional regulator
FNV58_RS21605	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS21620	COG1136	(ABC) transporter
FNV58_RS21640	COG0574	Belongs to the PEP-utilizing enzyme family
FNV58_RS21640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FNV58_RS21645	COG1940	carbohydrate kinase activity
FNV58_RS21645	COG1846	Transcriptional regulator
FNV58_RS21680	COG0477	Major facilitator Superfamily
FNV58_RS21710	COG0667	Aldo Keto reductase
FNV58_RS21720	COG1309	transcriptional regulator
FNV58_RS21725	COG0300	oxidoreductase activity
FNV58_RS21730	COG0423	glycine-tRNA ligase activity
FNV58_RS21735	COG0803	Belongs to the bacterial solute-binding protein 9 family
FNV58_RS21740	COG1121	(ABC) transporter
FNV58_RS21745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FNV58_RS21755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FNV58_RS21760	COG1381	Involved in DNA repair and RecF pathway recombination
FNV58_RS21770	COG0515	serine threonine protein kinase
FNV58_RS21770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV58_RS21810	COG0456	acetyltransferase
FNV58_RS21815	COG2197	response regulator
FNV58_RS21820	COG4585	Histidine kinase
FNV58_RS21825	COG1131	(ABC) transporter
FNV58_RS21840	COG2186	Transcriptional regulator
FNV58_RS21845	COG0747	negative chemotaxis
FNV58_RS21855	COG0444	Belongs to the ABC transporter superfamily
FNV58_RS21860	COG4608	Belongs to the ABC transporter superfamily
FNV58_RS21865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV58_RS21880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FNV58_RS21900	COG2723	6-phospho-beta-galactosidase activity
FNV58_RS21945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FNV58_RS21965	COG2315	Protein conserved in bacteria
FNV58_RS21975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FNV58_RS21995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV58_RS22000	COG1234	tRNA 3'-trailer cleavage
FNV58_RS22005	COG0537	adenosine 5'-monophosphoramidase activity
FNV58_RS22010	COG4946	Tricorn protease homolog
FNV58_RS22010	COG0793	Belongs to the peptidase S41A family
FNV58_RS22035	COG0484	heat shock protein binding
FNV58_RS22040	COG1420	regulation of RNA biosynthetic process
FNV58_RS22080	COG0481	GTPase activity
FNV58_RS22085	COG0268	Binds directly to 16S ribosomal RNA
FNV58_RS22145	COG1555	photosystem II stabilization
FNV58_RS22145	COG1596	polysaccharide export
FNV58_RS22150	COG1307	EDD domain protein, DegV family
FNV58_RS22160	COG0495	leucyl-tRNA aminoacylation
FNV58_RS22200	COG0477	Major facilitator Superfamily
FNV58_RS22215	COG0588	phosphoglycerate mutase activity
FNV58_RS22220	COG0799	negative regulation of ribosome biogenesis
FNV58_RS22230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FNV58_RS22235	COG0501	Belongs to the peptidase M48B family
FNV58_RS22250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FNV58_RS22260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FNV58_RS22270	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS22275	COG0463	Glycosyl transferase, family 2
FNV58_RS22275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV58_RS22280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV58_RS22280	COG0463	Glycosyl transferase, family 2
FNV58_RS22295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FNV58_RS22300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FNV58_RS22305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FNV58_RS22310	COG1530	ribonuclease E activity
FNV58_RS22340	COG1309	transcriptional regulator
FNV58_RS22345	COG0300	oxidoreductase activity
FNV58_RS22360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV58_RS22370	COG0640	Transcriptional regulator
FNV58_RS22375	COG2226	methyltransferase
FNV58_RS22385	COG0477	Major facilitator Superfamily
FNV58_RS22420	COG0772	Belongs to the SEDS family
FNV58_RS22425	COG0768	penicillin binding
FNV58_RS22440	COG1077	Cell shape determining protein MreB Mrl
FNV58_RS22445	COG0105	UTP biosynthetic process
FNV58_RS22455	COG0285	dihydrofolate synthase activity
FNV58_RS22460	COG0525	valine-tRNA ligase activity
FNV58_RS22470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FNV58_RS22475	COG0740	serine-type endopeptidase activity
FNV58_RS22480	COG0740	serine-type endopeptidase activity
FNV58_RS22485	COG0544	peptidyl-prolyl cis-trans isomerase activity
FNV58_RS22510	COG3594	Acyltransferase
FNV58_RS22525	COG4552	Acetyltransferase involved in intracellular survival and related
FNV58_RS22540	COG1113	amino acid transport
FNV58_RS22545	COG0515	serine threonine protein kinase
FNV58_RS22555	COG1268	BioY protein
FNV58_RS22560	COG1940	carbohydrate kinase activity
FNV58_RS22570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS22575	COG1116	anion transmembrane transporter activity
FNV58_RS22580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS22590	COG1113	amino acid transport
FNV58_RS22595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FNV58_RS22600	COG0588	phosphoglycerate mutase activity
FNV58_RS22610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FNV58_RS22690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FNV58_RS22725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS22750	COG2826	transposase and inactivated derivatives, IS30 family
FNV58_RS22755	COG1122	ATPase activity
FNV58_RS22780	COG0668	transmembrane transport
FNV58_RS22815	COG1175	transmembrane transport
FNV58_RS22820	COG0395	ABC-type sugar transport system, permease component
FNV58_RS22825	COG1486	melibiose metabolic process
FNV58_RS22840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV58_RS22870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FNV58_RS22875	COG2346	COG2346, Truncated hemoglobins
FNV58_RS22920	COG0489	protein tyrosine kinase activity
FNV58_RS22940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FNV58_RS22965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FNV58_RS22995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV58_RS23005	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FNV58_RS23055	COG0629	single-stranded DNA binding
FNV58_RS23160	COG3962	Belongs to the TPP enzyme family
FNV58_RS23165	COG3718	enzyme involved in inositol metabolism
FNV58_RS23175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS23200	COG2409	Drug exporters of the RND superfamily
FNV58_RS23230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FNV58_RS23250	COG1129	ABC transporter
FNV58_RS23260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS23265	COG1869	D-ribose catabolic process
FNV58_RS23285	COG0673	inositol 2-dehydrogenase activity
FNV58_RS23290	COG1609	Transcriptional regulator
FNV58_RS23295	COG1846	Transcriptional regulator
FNV58_RS23295	COG0456	acetyltransferase
FNV58_RS23305	COG0181	hydroxymethylbilane synthase activity
FNV58_RS23310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FNV58_RS23315	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV58_RS23355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV58_RS23360	COG2356	endonuclease I
FNV58_RS23365	COG0028	Belongs to the TPP enzyme family
FNV58_RS23375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV58_RS23395	COG1946	Acyl-CoA thioesterase
FNV58_RS23405	COG1309	transcriptional regulator
FNV58_RS23410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV58_RS23425	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS23460	COG0076	glutamate decarboxylase activity
FNV58_RS23465	COG3486	L-lysine 6-monooxygenase (NADPH) activity
FNV58_RS23500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV58_RS23510	COG0589	response to stress
FNV58_RS23525	COG4977	sequence-specific DNA binding
FNV58_RS23530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FNV58_RS23565	COG0395	ABC-type sugar transport system, permease component
FNV58_RS23580	COG3979	chitinase
FNV58_RS23590	COG0745	RESPONSE REGULATOR receiver
FNV58_RS23615	COG0406	alpha-ribazole phosphatase activity
FNV58_RS23665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS23700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV58_RS23705	COG0765	amino acid transport
FNV58_RS23710	COG0765	amino acid transport
FNV58_RS23715	COG1126	abc transporter atp-binding protein
FNV58_RS23730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS23745	COG1362	aminopeptidase activity
FNV58_RS23765	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS23775	COG3397	chitin binding
FNV58_RS23850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV58_RS23855	COG2188	Transcriptional regulator
FNV58_RS23870	COG0673	inositol 2-dehydrogenase activity
FNV58_RS23875	COG4702	Belongs to the UPF0303 family
FNV58_RS23885	COG0706	membrane insertase activity
FNV58_RS23885	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
FNV58_RS23905	COG3764	Sortase (surface protein transpeptidase)
FNV58_RS23915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FNV58_RS23975	COG3250	beta-galactosidase activity
FNV58_RS23990	COG1846	Transcriptional regulator
FNV58_RS24020	COG2733	membrane
FNV58_RS24035	COG1131	(ABC) transporter
FNV58_RS24050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV58_RS24085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FNV58_RS24095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FNV58_RS24100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNV58_RS24105	COG1263	PTS System
FNV58_RS24110	COG1263	PTS System
FNV58_RS24125	COG3631	Ketosteroid isomerase-related protein
FNV58_RS24170	COG1113	amino acid transport
FNV58_RS24185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FNV58_RS24195	COG1335	isochorismatase
FNV58_RS24230	COG0277	FAD linked oxidase domain protein
FNV58_RS24240	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FNV58_RS24250	COG1174	glycine betaine transport
FNV58_RS24270	COG3480	Lon protease (S16) C-terminal proteolytic domain
FNV58_RS24275	COG4948	Mandelate Racemase Muconate Lactonizing
FNV58_RS24285	COG0049	tRNA binding
FNV58_RS24295	COG0596	Alpha beta hydrolase
FNV58_RS24295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV58_RS24305	COG0531	amino acid
FNV58_RS24355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FNV58_RS24360	COG0395	ABC-type sugar transport system, permease component
FNV58_RS24365	COG1175	transmembrane transport
FNV58_RS24370	COG1653	transport
FNV58_RS24380	COG1678	Uncharacterized ACR, COG1678
FNV58_RS24385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FNV58_RS24390	COG0776	regulation of translation
FNV58_RS24400	COG3973	AAA domain
FNV58_RS24430	COG2223	nitrite transmembrane transporter activity
FNV58_RS24450	COG0583	DNA-binding transcription factor activity
FNV58_RS24465	COG1175	transmembrane transport
FNV58_RS24470	COG0395	ABC-type sugar transport system, permease component
FNV58_RS24475	COG1501	Belongs to the glycosyl hydrolase 31 family
FNV58_RS24480	COG1609	Transcriptional regulator
FNV58_RS24505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FNV58_RS24510	COG0793	Belongs to the peptidase S41A family
FNV58_RS24520	COG2884	Cell division ATP-binding protein ftsE
FNV58_RS24535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FNV58_RS24540	COG0515	serine threonine protein kinase
FNV58_RS24545	COG0515	serine threonine protein kinase
FNV58_RS24565	COG1175	transmembrane transport
FNV58_RS24570	COG0395	ABC-type sugar transport system, permease component
FNV58_RS24575	COG0463	Glycosyl transferase, family 2
FNV58_RS24575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV58_RS24580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV58_RS24600	COG1764	response to oxidative stress
FNV58_RS24605	COG1846	Transcriptional regulator
FNV58_RS24620	COG1216	Glycosyl transferase, family 2
FNV58_RS24645	COG2197	response regulator
FNV58_RS24670	COG1134	teichoic acid transport
FNV58_RS24675	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS24680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FNV58_RS24680	COG0463	Glycosyl transferase, family 2
FNV58_RS24690	COG2902	Dehydrogenase
FNV58_RS24715	COG0653	protein targeting
FNV58_RS24725	COG3214	Protein conserved in bacteria
FNV58_RS24730	COG2197	response regulator
FNV58_RS24735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FNV58_RS24745	COG0823	Involved in the tonB-independent uptake of proteins
FNV58_RS24750	COG5002	protein histidine kinase activity
FNV58_RS24750	COG5000	phosphorelay sensor kinase activity
FNV58_RS24755	COG0745	RESPONSE REGULATOR receiver
FNV58_RS24760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FNV58_RS24780	COG0714	Associated with various cellular activities
FNV58_RS24825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FNV58_RS24835	COG1482	cell wall glycoprotein biosynthetic process
FNV58_RS24845	COG2835	tetraacyldisaccharide 4'-kinase activity
FNV58_RS24850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNV58_RS24895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FNV58_RS24900	COG0778	Nitroreductase
FNV58_RS24900	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FNV58_RS24910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FNV58_RS24930	COG1316	TRANSCRIPTIONal
FNV58_RS24950	COG1316	TRANSCRIPTIONal
FNV58_RS24960	COG1011	Hydrolase
FNV58_RS24975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FNV58_RS25020	COG2205	protein histidine kinase activity
FNV58_RS25025	COG0745	RESPONSE REGULATOR receiver
FNV58_RS25030	COG3104	oligopeptide transport
FNV58_RS25085	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV58_RS25090	COG1191	sigma factor activity
FNV58_RS25100	COG1228	amidohydrolase
FNV58_RS25110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV58_RS25115	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FNV58_RS25160	COG2986	histidine ammonia-lyase
FNV58_RS25170	COG1174	glycine betaine transport
FNV58_RS25175	COG1174	glycine betaine transport
FNV58_RS25185	COG1609	Transcriptional regulator
FNV58_RS25200	COG0288	reversible hydration of carbon dioxide
FNV58_RS25215	COG2755	lipolytic protein G-D-S-L family
FNV58_RS25220	COG0183	Belongs to the thiolase family
FNV58_RS25265	COG0577	efflux transmembrane transporter activity
FNV58_RS25265	COG1136	(ABC) transporter
FNV58_RS25270	COG0577	efflux transmembrane transporter activity
FNV58_RS25275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FNV58_RS25280	COG1252	NADH dehydrogenase
FNV58_RS25300	COG0148	phosphopyruvate hydratase activity
FNV58_RS25310	COG1652	LysM domain
FNV58_RS25315	COG2124	cytochrome p450
FNV58_RS25435	COG1309	transcriptional regulator
FNV58_RS25450	COG0577	efflux transmembrane transporter activity
FNV58_RS25455	COG1136	(ABC) transporter
FNV58_RS25460	COG0477	Major facilitator Superfamily
FNV58_RS25470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV58_RS25500	COG4585	Histidine kinase
FNV58_RS25515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FNV58_RS25520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FNV58_RS25525	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FNV58_RS25530	COG0193	aminoacyl-tRNA hydrolase activity
FNV58_RS25540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FNV58_RS25550	COG1309	transcriptional regulator
FNV58_RS25560	COG4106	trans-aconitate 2-methyltransferase activity
FNV58_RS25570	COG2197	response regulator
FNV58_RS25580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FNV58_RS25625	COG0488	(ABC) transporter
FNV58_RS25635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FNV58_RS25640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FNV58_RS25650	COG0084	hydrolase, TatD family'
FNV58_RS25680	COG3224	Antibiotic biosynthesis monooxygenase
FNV58_RS25685	COG0590	tRNA wobble adenosine to inosine editing
FNV58_RS25690	COG0768	penicillin binding
FNV58_RS25715	COG0310	cobalt ion transport
FNV58_RS25725	COG1122	ATPase activity
FNV58_RS25730	COG1846	Transcriptional regulator
FNV58_RS25735	COG1764	response to oxidative stress
FNV58_RS25760	COG0667	Aldo Keto reductase
FNV58_RS25770	COG2409	Drug exporters of the RND superfamily
FNV58_RS25780	COG4946	Tricorn protease homolog
FNV58_RS25780	COG0793	Belongs to the peptidase S41A family
FNV58_RS25790	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS25795	COG2267	carboxylic ester hydrolase activity
FNV58_RS25800	COG2072	flavoprotein involved in K transport
FNV58_RS25810	COG0708	Exodeoxyribonuclease III
FNV58_RS25830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV58_RS25835	COG0521	Mo-molybdopterin cofactor biosynthetic process
FNV58_RS25835	COG0315	cyclic pyranopterin monophosphate synthase activity
FNV58_RS25840	COG0315	cyclic pyranopterin monophosphate synthase activity
FNV58_RS25850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FNV58_RS25855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FNV58_RS25865	COG3263	regulation of cellular component size
FNV58_RS25885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FNV58_RS25895	COG1970	mechanosensitive ion channel activity
FNV58_RS25915	COG1376	ErfK ybiS ycfS ynhG family protein
FNV58_RS25930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNV58_RS25930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNV58_RS25930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNV58_RS25940	COG1349	DNA-binding transcription factor activity
FNV58_RS25950	COG0477	Major facilitator Superfamily
FNV58_RS25970	COG1247	-acetyltransferase
FNV58_RS25975	COG3384	dioxygenase
FNV58_RS25980	COG1846	Transcriptional regulator
FNV58_RS26005	COG1414	Transcriptional regulator
FNV58_RS26010	COG0477	Major facilitator Superfamily
FNV58_RS26065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV58_RS26085	COG2197	response regulator
FNV58_RS26090	COG4585	Histidine kinase
FNV58_RS26145	COG2843	Capsule synthesis protein
FNV58_RS26150	COG2197	response regulator
FNV58_RS26180	COG2197	response regulator
FNV58_RS26185	COG4585	Histidine kinase
FNV58_RS26210	COG0277	FAD linked oxidase domain protein
FNV58_RS26220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV58_RS26230	COG2188	Transcriptional regulator
FNV58_RS26255	COG0386	Belongs to the glutathione peroxidase family
FNV58_RS26270	COG1686	Belongs to the peptidase S11 family
FNV58_RS26325	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FNV58_RS26345	COG1733	regulation of RNA biosynthetic process
FNV58_RS26355	COG4221	oxidoreductase activity
FNV58_RS26360	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS26365	COG2267	carboxylic ester hydrolase activity
FNV58_RS26395	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FNV58_RS26420	COG3903	Transcriptional regulator
FNV58_RS26420	COG3629	intracellular signal transduction
FNV58_RS26435	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS26450	COG1024	Enoyl-CoA hydratase
FNV58_RS26455	COG0515	serine threonine protein kinase
FNV58_RS26455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV58_RS26475	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS26485	COG2226	methyltransferase
FNV58_RS26490	COG0259	pyridoxamine-phosphate oxidase activity
FNV58_RS26540	COG1024	Enoyl-CoA hydratase
FNV58_RS26545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV58_RS26565	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS26570	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS26590	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS26595	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS26605	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS26620	COG1595	DNA-templated transcription, initiation
FNV58_RS26670	COG2267	carboxylic ester hydrolase activity
FNV58_RS26680	COG4821	SIS domain
FNV58_RS26705	COG0259	pyridoxamine-phosphate oxidase activity
FNV58_RS26715	COG1024	Enoyl-CoA hydratase
FNV58_RS26720	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS26735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV58_RS26770	COG1132	(ABC) transporter
FNV58_RS26775	COG0247	lactate metabolic process
FNV58_RS26775	COG0277	FAD linked oxidase domain protein
FNV58_RS26800	COG2124	cytochrome p450
FNV58_RS26810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FNV58_RS26830	COG0789	Transcriptional regulator
FNV58_RS26840	COG0667	Aldo Keto reductase
FNV58_RS26855	COG1846	Transcriptional regulator
FNV58_RS26865	COG2252	PERMEase
FNV58_RS26875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FNV58_RS26905	COG2814	Major facilitator Superfamily
FNV58_RS26915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FNV58_RS26920	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FNV58_RS26925	COG1278	Cold shock
FNV58_RS26950	COG1061	Type III restriction enzyme res subunit
FNV58_RS26965	COG3973	AAA domain
FNV58_RS26970	COG3142	Participates in the control of copper homeostasis
FNV58_RS27005	COG1737	Transcriptional regulator
FNV58_RS27010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FNV58_RS27015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNV58_RS27015	COG1263	PTS System
FNV58_RS27055	COG2084	Dehydrogenase
FNV58_RS27070	COG0459	protein refolding
FNV58_RS27090	COG0463	Glycosyl transferase, family 2
FNV58_RS27145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV58_RS27185	COG0308	aminopeptidase N
FNV58_RS27215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV58_RS27215	COG0723	plastoquinol--plastocyanin reductase activity
FNV58_RS27265	COG3842	ATPase activity
FNV58_RS27285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FNV58_RS27290	COG0215	cysteine-tRNA ligase activity
FNV58_RS27295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FNV58_RS27300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FNV58_RS27305	COG1329	Transcriptional regulator
FNV58_RS27325	COG5002	protein histidine kinase activity
FNV58_RS27360	COG0222	ribosome binding
FNV58_RS27365	COG0588	phosphoglycerate mutase activity
FNV58_RS27395	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS27430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS27435	COG1090	epimerase
FNV58_RS27440	COG1595	DNA-templated transcription, initiation
FNV58_RS27450	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS27460	COG1309	transcriptional regulator
FNV58_RS27465	COG1063	alcohol dehydrogenase
FNV58_RS27490	COG2188	Transcriptional regulator
FNV58_RS27500	COG2188	Transcriptional regulator
FNV58_RS27510	COG4552	Acetyltransferase involved in intracellular survival and related
FNV58_RS27525	COG1490	D-aminoacyl-tRNA deacylase activity
FNV58_RS27530	COG0354	folic acid binding
FNV58_RS27540	COG3485	protocatechuate 3,4-dioxygenase
FNV58_RS27580	COG2897	thiosulfate sulfurtransferase activity
FNV58_RS27610	COG0745	RESPONSE REGULATOR receiver
FNV58_RS27615	COG1609	Transcriptional regulator
FNV58_RS27650	COG0745	RESPONSE REGULATOR receiver
FNV58_RS27655	COG1132	(ABC) transporter
FNV58_RS27660	COG0737	Belongs to the 5'-nucleotidase family
FNV58_RS27665	COG0456	acetyltransferase
FNV58_RS27680	COG1131	(ABC) transporter
FNV58_RS27695	COG1725	Transcriptional regulator
FNV58_RS27700	COG1131	(ABC) transporter
FNV58_RS27715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FNV58_RS27725	COG0494	nUDIX hydrolase
FNV58_RS27725	COG0406	alpha-ribazole phosphatase activity
FNV58_RS27745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNV58_RS27750	COG0306	phosphate transporter
FNV58_RS27760	COG1937	Protein conserved in bacteria
FNV58_RS27775	COG0277	FAD linked oxidase domain protein
FNV58_RS27780	COG0671	phosphoesterase, PA-phosphatase related
FNV58_RS27785	COG1196	nuclear chromosome segregation
FNV58_RS27785	COG0741	lytic transglycosylase activity
FNV58_RS27785	COG0739	heme binding
FNV58_RS27895	COG1252	NADH dehydrogenase
FNV58_RS27905	COG1470	cell adhesion involved in biofilm formation
FNV58_RS27905	COG0366	Alpha amylase catalytic
FNV58_RS27925	COG0579	oxidoreductase
FNV58_RS27930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FNV58_RS27940	COG0667	Aldo Keto reductase
FNV58_RS27965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FNV58_RS27965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FNV58_RS27975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV58_RS27995	COG0513	Belongs to the DEAD box helicase family
FNV58_RS28035	COG1643	Atp-dependent helicase
FNV58_RS28070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FNV58_RS28090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FNV58_RS28095	COG0047	phosphoribosylformylglycinamidine synthase activity
FNV58_RS28100	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FNV58_RS28130	COG3850	Histidine kinase
FNV58_RS28135	COG2197	response regulator
FNV58_RS28145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FNV58_RS28160	COG0151	Belongs to the GarS family
FNV58_RS28245	COG0433	COG0433 Predicted ATPase
FNV58_RS28260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FNV58_RS28295	COG1191	sigma factor activity
FNV58_RS28300	COG1191	sigma factor activity
FNV58_RS28330	COG3467	pyridoxamine 5'-phosphate
FNV58_RS28340	COG0477	Major facilitator Superfamily
FNV58_RS28345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV58_RS28355	COG2205	protein histidine kinase activity
FNV58_RS28360	COG0745	RESPONSE REGULATOR receiver
FNV58_RS28370	COG2329	Antibiotic biosynthesis monooxygenase
FNV58_RS28385	COG1846	Transcriptional regulator
FNV58_RS28430	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS28435	COG1595	DNA-templated transcription, initiation
FNV58_RS28450	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS28460	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS28490	COG2318	DinB family
FNV58_RS28520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FNV58_RS28540	COG0653	protein targeting
FNV58_RS28560	COG0006	proline dipeptidase activity
FNV58_RS28575	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FNV58_RS28595	COG2409	Drug exporters of the RND superfamily
FNV58_RS28600	COG4585	Histidine kinase
FNV58_RS28635	COG2837	iron assimilation
FNV58_RS28645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FNV58_RS28650	COG0561	phosphatase activity
FNV58_RS28680	COG1131	(ABC) transporter
FNV58_RS28690	COG0789	Transcriptional regulator
FNV58_RS28695	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FNV58_RS28705	COG0561	phosphatase activity
FNV58_RS28715	COG4988	ABC transporter
FNV58_RS28720	COG1294	oxidase, subunit
FNV58_RS28725	COG1271	oxidase subunit
FNV58_RS28730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV58_RS28735	COG1609	Transcriptional regulator
FNV58_RS28755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FNV58_RS28780	COG0662	Cupin 2, conserved barrel domain protein
FNV58_RS28785	COG1950	PFAM Membrane protein of
FNV58_RS28790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV58_RS28795	COG0626	cystathionine gamma-synthase activity
FNV58_RS28830	COG2814	Major facilitator Superfamily
FNV58_RS28850	COG0305	Participates in initiation and elongation during chromosome replication
FNV58_RS28865	COG0359	binds to the 23S rRNA
FNV58_RS28870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FNV58_RS28875	COG0629	single-stranded DNA binding
FNV58_RS28880	COG0360	Binds together with S18 to 16S ribosomal RNA
FNV58_RS28905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FNV58_RS28930	COG0617	tRNA 3'-terminal CCA addition
FNV58_RS28950	COG1595	DNA-templated transcription, initiation
FNV58_RS28960	COG0492	ferredoxin-NADP+ reductase activity
FNV58_RS28965	COG3118	belongs to the thioredoxin family
FNV58_RS28980	COG1192	Involved in chromosome partitioning
FNV58_RS28985	COG0357	Ribosomal RNA small subunit methyltransferase G
FNV58_RS28995	COG0706	membrane insertase activity
FNV58_RS29000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FNV58_RS29005	COG0594	ribonuclease P activity
FNV58_RS29010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FNV58_RS29015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FNV58_RS29025	COG0592	DNA-directed DNA polymerase activity
FNV58_RS29030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FNV58_RS29035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FNV58_RS29040	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FNV58_RS29045	COG0187	DNA topoisomerase II activity
FNV58_RS29050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FNV58_RS29085	COG0515	serine threonine protein kinase
FNV58_RS29110	COG0705	Rhomboid family
FNV58_RS29125	COG3764	Sortase (surface protein transpeptidase)
FNV58_RS29140	COG3764	Sortase (surface protein transpeptidase)
FNV58_RS29145	COG3764	Sortase (surface protein transpeptidase)
FNV58_RS29150	COG0515	serine threonine protein kinase
FNV58_RS29160	COG0768	penicillin binding
FNV58_RS29175	COG1716	ATPase activity
FNV58_RS29180	COG1716	ATPase activity
FNV58_RS29205	COG0745	RESPONSE REGULATOR receiver
FNV58_RS29220	COG4770	biotin carboxylase activity
FNV58_RS29235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS29280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV58_RS29310	COG0475	glutathione-regulated potassium exporter activity
FNV58_RS29320	COG1733	regulation of RNA biosynthetic process
FNV58_RS29325	COG0477	Major facilitator Superfamily
FNV58_RS29345	COG0277	FAD linked oxidase domain protein
FNV58_RS29360	COG0702	epimerase
FNV58_RS29365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FNV58_RS29370	COG1733	regulation of RNA biosynthetic process
FNV58_RS29415	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV58_RS29420	COG1309	transcriptional regulator
FNV58_RS29425	COG1522	sequence-specific DNA binding
FNV58_RS29445	COG0746	molybdenum cofactor guanylyltransferase activity
FNV58_RS29460	COG3321	synthase
FNV58_RS29460	COG0604	alcohol dehydrogenase
FNV58_RS29460	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS29475	COG0515	serine threonine protein kinase
FNV58_RS29480	COG0515	serine threonine protein kinase
FNV58_RS29505	COG0022	dehydrogenase e1 component
FNV58_RS29510	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV58_RS29565	COG1362	aminopeptidase activity
FNV58_RS29570	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS29580	COG1741	Belongs to the pirin family
FNV58_RS29595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FNV58_RS29625	COG3866	Pectate lyase
FNV58_RS29635	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNV58_RS29655	COG1289	transmembrane transporter activity
FNV58_RS29665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV58_RS29670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS29700	COG2205	protein histidine kinase activity
FNV58_RS29705	COG0745	RESPONSE REGULATOR receiver
FNV58_RS29720	COG1653	transport
FNV58_RS29740	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FNV58_RS29750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV58_RS29790	COG1278	Cold shock
FNV58_RS29825	COG0725	ABC transporter, periplasmic molybdate-binding protein
FNV58_RS29875	COG2815	serine threonine protein kinase
FNV58_RS29875	COG0515	serine threonine protein kinase
FNV58_RS29890	COG1595	DNA-templated transcription, initiation
FNV58_RS29900	COG0561	phosphatase activity
FNV58_RS29950	COG0745	RESPONSE REGULATOR receiver
FNV58_RS29955	COG5002	protein histidine kinase activity
FNV58_RS29965	COG2409	Drug exporters of the RND superfamily
FNV58_RS29970	COG4585	Histidine kinase
FNV58_RS29975	COG2197	response regulator
FNV58_RS29995	COG0640	Transcriptional regulator
FNV58_RS30000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FNV58_RS30010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FNV58_RS30015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV58_RS30085	COG2326	polyphosphate kinase activity
FNV58_RS30090	COG3387	PFAM Glycoside hydrolase 15-related
FNV58_RS30095	COG0477	Major facilitator Superfamily
FNV58_RS30165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FNV58_RS30185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV58_RS30185	COG0515	serine threonine protein kinase
FNV58_RS30210	COG1733	regulation of RNA biosynthetic process
FNV58_RS30240	COG2205	protein histidine kinase activity
FNV58_RS30245	COG0745	RESPONSE REGULATOR receiver
FNV58_RS30315	COG0717	Belongs to the dCTP deaminase family
FNV58_RS30340	COG0247	lactate metabolic process
FNV58_RS30340	COG2181	nitrate reductase activity
FNV58_RS30345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNV58_RS30350	COG0443	Heat shock 70 kDa protein
FNV58_RS30355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FNV58_RS30360	COG0484	heat shock protein binding
FNV58_RS30365	COG0789	Transcriptional regulator
FNV58_RS30375	COG4213	ABC transporter substrate-binding protein
FNV58_RS30400	COG1305	Transglutaminase-like
FNV58_RS30445	COG0542	response to heat
FNV58_RS30480	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FNV58_RS30495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FNV58_RS30500	COG0191	fructose-bisphosphate aldolase activity
FNV58_RS30520	COG3844	kynureninase activity
FNV58_RS30545	COG4585	Histidine kinase
FNV58_RS30550	COG2197	response regulator
FNV58_RS30555	COG4585	Histidine kinase
FNV58_RS30560	COG2197	response regulator
FNV58_RS30575	COG3559	Exporter of polyketide antibiotics
FNV58_RS30580	COG1131	(ABC) transporter
FNV58_RS30595	COG4303	Ethanolamine ammonia lyase large subunit
FNV58_RS30610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FNV58_RS30615	COG0737	Belongs to the 5'-nucleotidase family
FNV58_RS30625	COG1802	Transcriptional regulator
FNV58_RS30630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FNV58_RS30635	COG0693	protein deglycase activity
FNV58_RS30665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FNV58_RS30670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FNV58_RS30705	COG5000	phosphorelay sensor kinase activity
FNV58_RS30705	COG5002	protein histidine kinase activity
FNV58_RS30785	COG0515	serine threonine protein kinase
FNV58_RS30830	COG4152	abc transporter atp-binding protein
FNV58_RS30890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FNV58_RS30905	COG1132	(ABC) transporter
FNV58_RS30930	COG1408	metallophosphoesterase
FNV58_RS30955	COG0003	Pfam Anion-transporting ATPase
FNV58_RS30980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS31010	COG0596	Alpha beta hydrolase
FNV58_RS31020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FNV58_RS31025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV58_RS31030	COG0659	secondary active sulfate transmembrane transporter activity
FNV58_RS31090	COG1205	dead DEAH box helicase
FNV58_RS31090	COG1111	helicase
FNV58_RS31095	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV58_RS31100	COG2172	sigma factor antagonist activity
FNV58_RS31105	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FNV58_RS31120	COG0515	serine threonine protein kinase
FNV58_RS31120	COG2815	serine threonine protein kinase
FNV58_RS31130	COG1754	DNA topoisomerase type I activity
FNV58_RS31130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FNV58_RS31135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FNV58_RS31140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FNV58_RS31270	COG1136	(ABC) transporter
FNV58_RS31280	COG2197	response regulator
FNV58_RS31350	COG3629	intracellular signal transduction
FNV58_RS31350	COG3903	Transcriptional regulator
FNV58_RS31355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV58_RS31355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNV58_RS31380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FNV58_RS31385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FNV58_RS31390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNV58_RS31395	COG0254	rRNA binding
FNV58_RS31405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FNV58_RS31425	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS31445	COG0076	glutamate decarboxylase activity
FNV58_RS31455	COG0789	Transcriptional regulator
FNV58_RS31460	COG0393	Putative heavy-metal-binding
FNV58_RS31475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FNV58_RS31480	COG2027	D-alanyl-D-alanine carboxypeptidase
FNV58_RS31490	COG0037	tRNA processing
FNV58_RS31505	COG0302	gtp cyclohydrolase
FNV58_RS31520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FNV58_RS31535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNV58_RS31535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FNV58_RS31560	COG0649	NAD binding
FNV58_RS31580	COG2197	response regulator
FNV58_RS31585	COG1660	Displays ATPase and GTPase activities
FNV58_RS31610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FNV58_RS31615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FNV58_RS31625	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FNV58_RS31645	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FNV58_RS31675	COG0739	heme binding
FNV58_RS31695	COG2205	protein histidine kinase activity
FNV58_RS31700	COG0745	RESPONSE REGULATOR receiver
FNV58_RS31710	COG1595	DNA-templated transcription, initiation
FNV58_RS31725	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FNV58_RS31745	COG0248	Ppx GppA phosphatase
FNV58_RS31750	COG1082	Xylose isomerase domain protein TIM barrel
FNV58_RS31755	COG1309	transcriptional regulator
FNV58_RS31760	COG0129	dihydroxy-acid dehydratase activity
FNV58_RS31765	COG0515	serine threonine protein kinase
FNV58_RS31765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FNV58_RS31775	COG4991	sh3 domain protein
FNV58_RS31785	COG2226	methyltransferase
FNV58_RS31795	COG1129	ABC transporter
FNV58_RS31795	COG0842	Transport permease protein
FNV58_RS31805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FNV58_RS31810	COG0180	Tryptophanyl-tRNA synthetase
FNV58_RS31850	COG0123	including yeast histone deacetylase and acetoin utilization protein
FNV58_RS31900	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FNV58_RS31905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FNV58_RS31910	COG0181	hydroxymethylbilane synthase activity
FNV58_RS31915	COG1648	precorrin-2 dehydrogenase activity
FNV58_RS31915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FNV58_RS31920	COG0113	porphobilinogen synthase activity
FNV58_RS31950	COG0018	arginyl-trna synthetase
FNV58_RS31955	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FNV58_RS31975	COG1690	Belongs to the RtcB family
FNV58_RS31995	COG1742	UPF0060 membrane protein
FNV58_RS32005	COG1846	Transcriptional regulator
FNV58_RS32010	COG1733	regulation of RNA biosynthetic process
FNV58_RS32025	COG0583	DNA-binding transcription factor activity
FNV58_RS32040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS32070	COG0531	amino acid
FNV58_RS32080	COG1136	(ABC) transporter
FNV58_RS32090	COG2197	response regulator
FNV58_RS32105	COG0501	Belongs to the peptidase M48B family
FNV58_RS32115	COG1968	undecaprenyl-diphosphatase activity
FNV58_RS32140	COG0531	amino acid
FNV58_RS32160	COG0598	Magnesium transport protein CorA
FNV58_RS32165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV58_RS32180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FNV58_RS32185	COG0406	alpha-ribazole phosphatase activity
FNV58_RS32205	COG1333	cytochrome c biogenesis protein
FNV58_RS32210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FNV58_RS32255	COG2226	methyltransferase
FNV58_RS32260	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS32260	COG0604	alcohol dehydrogenase
FNV58_RS32260	COG3321	synthase
FNV58_RS32265	COG0640	Transcriptional regulator
FNV58_RS32285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FNV58_RS32290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FNV58_RS32295	COG0163	prenyltransferase activity
FNV58_RS32305	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FNV58_RS32320	COG1309	transcriptional regulator
FNV58_RS32335	COG0183	Belongs to the thiolase family
FNV58_RS32345	COG1278	Cold shock
FNV58_RS32350	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FNV58_RS32365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FNV58_RS32395	COG2226	methyltransferase
FNV58_RS32425	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV58_RS32430	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV58_RS32435	COG0649	NAD binding
FNV58_RS32445	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FNV58_RS32450	COG1034	ATP synthesis coupled electron transport
FNV58_RS32455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FNV58_RS32460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV58_RS32470	COG0713	ATP synthesis coupled electron transport
FNV58_RS32475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FNV58_RS32485	COG1007	ATP synthesis coupled electron transport
FNV58_RS32490	COG0514	ATP-dependent DNA helicase (RecQ)
FNV58_RS32495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FNV58_RS32500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FNV58_RS32505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS32520	COG2188	Transcriptional regulator
FNV58_RS32540	COG0492	ferredoxin-NADP+ reductase activity
FNV58_RS32550	COG5280	Phage tail tape measure protein TP901
FNV58_RS32550	COG3953	SLT domain
FNV58_RS32565	COG0142	geranyltranstransferase activity
FNV58_RS32580	COG1131	(ABC) transporter
FNV58_RS32590	COG0655	NAD(P)H dehydrogenase (quinone) activity
FNV58_RS32615	COG0702	epimerase
FNV58_RS32620	COG1733	regulation of RNA biosynthetic process
FNV58_RS32625	COG1013	pyruvate-flavodoxin oxidoreductase activity
FNV58_RS32630	COG0674	pyruvate-flavodoxin oxidoreductase activity
FNV58_RS32630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FNV58_RS32650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV58_RS32655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV58_RS32660	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV58_RS32665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FNV58_RS32670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FNV58_RS32675	COG0839	Belongs to the complex I subunit 6 family
FNV58_RS32680	COG0713	ATP synthesis coupled electron transport
FNV58_RS32695	COG1007	ATP synthesis coupled electron transport
FNV58_RS32700	COG0501	Belongs to the peptidase M48B family
FNV58_RS32705	COG3304	Inner membrane component domain
FNV58_RS32725	COG2261	transglycosylase associated protein
FNV58_RS32730	COG1666	GTP binding
FNV58_RS32810	COG2188	Transcriptional regulator
FNV58_RS32835	COG0702	epimerase
FNV58_RS32840	COG0402	S-adenosylhomocysteine deaminase activity
FNV58_RS32855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNV58_RS32860	COG2030	dehydratase
FNV58_RS32875	COG0477	Major facilitator Superfamily
FNV58_RS32880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FNV58_RS32885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV58_RS32900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV58_RS32905	COG0436	Aminotransferase
FNV58_RS32925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FNV58_RS32930	COG0081	regulation of translation
FNV58_RS32945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FNV58_RS32950	COG0222	ribosome binding
FNV58_RS32960	COG0085	RNA polymerase activity
FNV58_RS32965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FNV58_RS32995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV58_RS33000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FNV58_RS33005	COG0049	tRNA binding
FNV58_RS33010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FNV58_RS33015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FNV58_RS33030	COG2124	cytochrome p450
FNV58_RS33050	COG1404	Belongs to the peptidase S8 family
FNV58_RS33085	COG0051	transcription antitermination factor activity, RNA binding
FNV58_RS33090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FNV58_RS33095	COG0088	Forms part of the polypeptide exit tunnel
FNV58_RS33100	COG0089	rRNA binding
FNV58_RS33105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FNV58_RS33110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FNV58_RS33115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FNV58_RS33120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FNV58_RS33125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FNV58_RS33130	COG0255	Belongs to the universal ribosomal protein uL29 family
FNV58_RS33135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FNV58_RS33140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FNV58_RS33145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FNV58_RS33150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FNV58_RS33155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FNV58_RS33165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FNV58_RS33170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FNV58_RS33175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FNV58_RS33180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FNV58_RS33185	COG1841	ribosomal large subunit assembly
FNV58_RS33190	COG0200	Binds to the 23S rRNA
FNV58_RS33200	COG0563	adenylate kinase activity
FNV58_RS33210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FNV58_RS33215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FNV58_RS33220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FNV58_RS33225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FNV58_RS33230	COG0202	RNA polymerase activity
FNV58_RS33235	COG0203	ribosomal protein L17
FNV58_RS33240	COG0101	tRNA pseudouridine synthase activity
FNV58_RS33250	COG1215	transferase activity, transferring glycosyl groups
FNV58_RS33255	COG4124	Belongs to the glycosyl hydrolase 26 family
FNV58_RS33255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FNV58_RS33270	COG0463	Glycosyl transferase, family 2
FNV58_RS33280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FNV58_RS33285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FNV58_RS33290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNV58_RS33295	COG1072	(Pantothenic acid kinase))
FNV58_RS33300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV58_RS33345	COG0736	holo-[acyl-carrier-protein] synthase activity
FNV58_RS33360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FNV58_RS33370	COG0802	atpase or kinase
FNV58_RS33390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FNV58_RS33400	COG1609	Transcriptional regulator
FNV58_RS33410	COG1175	transmembrane transport
FNV58_RS33415	COG0395	ABC-type sugar transport system, permease component
FNV58_RS33420	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV58_RS33425	COG1609	Transcriptional regulator
FNV58_RS33450	COG4941	Belongs to the sigma-70 factor family
FNV58_RS33460	COG0726	polysaccharide deacetylase
FNV58_RS33465	COG0726	polysaccharide deacetylase
FNV58_RS33470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FNV58_RS33475	COG0459	protein refolding
FNV58_RS33485	COG4221	oxidoreductase activity
FNV58_RS33495	COG0583	DNA-binding transcription factor activity
FNV58_RS33510	COG1595	DNA-templated transcription, initiation
FNV58_RS33520	COG0516	GMP reductase activity
FNV58_RS33535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FNV58_RS33555	COG0515	serine threonine protein kinase
FNV58_RS33560	COG2815	serine threonine protein kinase
FNV58_RS33560	COG0515	serine threonine protein kinase
FNV58_RS33565	COG0515	serine threonine protein kinase
FNV58_RS33570	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS33595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FNV58_RS33595	COG0519	Catalyzes the synthesis of GMP from XMP
FNV58_RS33640	COG2197	response regulator
FNV58_RS33675	COG0739	heme binding
FNV58_RS33685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS33685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS33700	COG0714	Associated with various cellular activities
FNV58_RS33705	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FNV58_RS33710	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FNV58_RS33725	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV58_RS33760	COG0138	bifunctional purine biosynthesis protein purh
FNV58_RS33780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FNV58_RS33805	COG0039	L-malate dehydrogenase activity
FNV58_RS33825	COG0456	acetyltransferase
FNV58_RS33825	COG1846	Transcriptional regulator
FNV58_RS33830	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS33840	COG0517	IMP dehydrogenase activity
FNV58_RS33840	COG4175	Glycine betaine
FNV58_RS33845	COG4176	ABC-type proline glycine betaine transport system permease component
FNV58_RS33860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS33865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS33875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS33885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS33895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV58_RS33900	COG0512	Glutamine amidotransferase of anthranilate synthase
FNV58_RS33900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FNV58_RS33905	COG3224	Antibiotic biosynthesis monooxygenase
FNV58_RS33925	COG0754	glutathionylspermidine amidase activity
FNV58_RS33930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FNV58_RS33935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV58_RS33945	COG0180	Tryptophanyl-tRNA synthetase
FNV58_RS33980	COG1295	ribonuclease BN
FNV58_RS33985	COG1686	Belongs to the peptidase S11 family
FNV58_RS33995	COG1408	metallophosphoesterase
FNV58_RS34015	COG2205	protein histidine kinase activity
FNV58_RS34020	COG0745	RESPONSE REGULATOR receiver
FNV58_RS34025	COG2409	Drug exporters of the RND superfamily
FNV58_RS34070	COG1053	succinate dehydrogenase
FNV58_RS34080	COG2009	succinate dehydrogenase
FNV58_RS34090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FNV58_RS34125	COG1595	DNA-templated transcription, initiation
FNV58_RS34130	COG1595	DNA-templated transcription, initiation
FNV58_RS34145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS34145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS34160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV58_RS34170	COG1216	Glycosyl transferase, family 2
FNV58_RS34185	COG2089	acid synthase
FNV58_RS34200	COG0573	inorganic phosphate transmembrane transporter activity
FNV58_RS34235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNV58_RS34240	COG4195	phage-related replication protein
FNV58_RS34295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FNV58_RS34295	COG1473	amidohydrolase
FNV58_RS34300	COG1744	ABC transporter substrate-binding protein PnrA-like
FNV58_RS34305	COG1744	ABC transporter substrate-binding protein PnrA-like
FNV58_RS34310	COG3845	ABC transporter
FNV58_RS34315	COG4603	Belongs to the binding-protein-dependent transport system permease family
FNV58_RS34320	COG1079	Belongs to the binding-protein-dependent transport system permease family
FNV58_RS34350	COG0592	DNA-directed DNA polymerase activity
FNV58_RS34355	COG2814	Major facilitator Superfamily
FNV58_RS34360	COG0583	DNA-binding transcription factor activity
FNV58_RS34370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV58_RS34395	COG2205	protein histidine kinase activity
FNV58_RS34400	COG0745	RESPONSE REGULATOR receiver
FNV58_RS34405	COG1595	DNA-templated transcription, initiation
FNV58_RS34420	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS34425	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS34485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNV58_RS34500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNV58_RS34530	COG4770	biotin carboxylase activity
FNV58_RS34540	COG0424	maF-like protein
FNV58_RS34555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV58_RS34565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV58_RS34575	COG1024	Enoyl-CoA hydratase
FNV58_RS34585	COG2986	histidine ammonia-lyase
FNV58_RS34590	COG1278	Cold shock
FNV58_RS34625	COG1136	(ABC) transporter
FNV58_RS34635	COG1404	Belongs to the peptidase S8 family
FNV58_RS34650	COG1064	alcohol dehydrogenase
FNV58_RS34655	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV58_RS34660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNV58_RS34670	COG2132	Multicopper oxidase
FNV58_RS34710	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FNV58_RS34720	COG3173	Aminoglycoside phosphotransferase
FNV58_RS34745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV58_RS34770	COG2255	four-way junction helicase activity
FNV58_RS34775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FNV58_RS34820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FNV58_RS34830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV58_RS34855	COG1331	Highly conserved protein containing a thioredoxin domain
FNV58_RS34885	COG1309	transcriptional regulator
FNV58_RS34890	COG0477	Major facilitator Superfamily
FNV58_RS34900	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FNV58_RS35000	COG0436	Aminotransferase
FNV58_RS35015	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FNV58_RS35030	COG1414	Transcriptional regulator
FNV58_RS35035	COG0251	oxidation-reduction process
FNV58_RS35040	COG2610	gluconate transmembrane transporter activity
FNV58_RS35100	COG2894	cell division
FNV58_RS35130	COG2197	response regulator
FNV58_RS35150	COG2885	chlorophyll binding
FNV58_RS35155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV58_RS35185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FNV58_RS35195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FNV58_RS35210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS35215	COG0450	alkyl hydroperoxide reductase
FNV58_RS35230	COG1136	(ABC) transporter
FNV58_RS35250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNV58_RS35280	COG0114	fumarate hydratase activity
FNV58_RS35300	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FNV58_RS35300	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FNV58_RS35325	COG0778	Nitroreductase
FNV58_RS35330	COG1722	exodeoxyribonuclease VII activity
FNV58_RS35335	COG1570	exodeoxyribonuclease VII activity
FNV58_RS35340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FNV58_RS35355	COG0012	GTP binding
FNV58_RS35445	COG1053	succinate dehydrogenase
FNV58_RS35465	COG1217	gtp-binding protein TYPA
FNV58_RS35480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV58_RS35485	COG0444	Belongs to the ABC transporter superfamily
FNV58_RS35490	COG4608	Belongs to the ABC transporter superfamily
FNV58_RS35495	COG0346	lactoylglutathione lyase activity
FNV58_RS35505	COG0601	transmembrane transport
FNV58_RS35510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV58_RS35515	COG0444	Belongs to the ABC transporter superfamily
FNV58_RS35520	COG4608	Belongs to the ABC transporter superfamily
FNV58_RS35535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV58_RS35555	COG1131	(ABC) transporter
FNV58_RS35565	COG4585	Histidine kinase
FNV58_RS35570	COG2197	response regulator
FNV58_RS35605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV58_RS35615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FNV58_RS35625	COG0519	Catalyzes the synthesis of GMP from XMP
FNV58_RS35630	COG1024	Enoyl-CoA hydratase
FNV58_RS35645	COG1595	DNA-templated transcription, initiation
FNV58_RS35655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FNV58_RS35660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV58_RS35685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FNV58_RS35695	COG0598	Magnesium transport protein CorA
FNV58_RS35705	COG2814	Major facilitator Superfamily
FNV58_RS35720	COG2095	MarC family integral membrane protein
FNV58_RS35730	COG1432	Conserved Protein
FNV58_RS35735	COG0596	Alpha beta hydrolase
FNV58_RS35780	COG0747	negative chemotaxis
FNV58_RS35785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV58_RS35790	COG0601	transmembrane transport
FNV58_RS35850	COG0210	DNA helicase
FNV58_RS35855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV58_RS35895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FNV58_RS35950	COG3480	Lon protease (S16) C-terminal proteolytic domain
FNV58_RS35960	COG1615	UPF0182 protein
FNV58_RS35985	COG0753	catalase activity
FNV58_RS35990	COG0517	IMP dehydrogenase activity
FNV58_RS35990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FNV58_RS35995	COG0483	inositol monophosphate 1-phosphatase activity
FNV58_RS36015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FNV58_RS36025	COG2135	peptidase activity
FNV58_RS36035	COG1595	DNA-templated transcription, initiation
FNV58_RS36040	COG5662	AntiSigma factor
FNV58_RS36045	COG2199	diguanylate cyclase activity
FNV58_RS36045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FNV58_RS36060	COG0242	peptide deformylase activity
FNV58_RS36070	COG2124	cytochrome p450
FNV58_RS36090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FNV58_RS36115	COG2188	Transcriptional regulator
FNV58_RS36120	COG2182	Extracellular solute-binding protein
FNV58_RS36125	COG1175	transmembrane transport
FNV58_RS36130	COG0395	ABC-type sugar transport system, permease component
FNV58_RS36135	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV58_RS36140	COG0363	glucosamine-6-phosphate deaminase activity
FNV58_RS36145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNV58_RS36160	COG1597	lipid kinase activity
FNV58_RS36205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV58_RS36210	COG0142	geranyltranstransferase activity
FNV58_RS36280	COG4106	trans-aconitate 2-methyltransferase activity
FNV58_RS36285	COG1126	abc transporter atp-binding protein
FNV58_RS36305	COG0281	malic enzyme
FNV58_RS36310	COG0604	alcohol dehydrogenase
FNV58_RS36345	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV58_RS36345	COG0567	Dehydrogenase, E1 component
FNV58_RS36350	COG2205	protein histidine kinase activity
FNV58_RS36355	COG0745	RESPONSE REGULATOR receiver
FNV58_RS36385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FNV58_RS36470	COG0701	Predicted permease
FNV58_RS36475	COG0768	penicillin binding
FNV58_RS36480	COG0772	Belongs to the SEDS family
FNV58_RS36490	COG2205	protein histidine kinase activity
FNV58_RS36515	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FNV58_RS36525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FNV58_RS36630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FNV58_RS36765	COG0018	arginyl-trna synthetase
FNV58_RS36770	COG0019	diaminopimelate decarboxylase activity
FNV58_RS36775	COG0460	homoserine dehydrogenase
FNV58_RS36780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FNV58_RS36785	COG0083	homoserine kinase activity
FNV58_RS36800	COG1316	TRANSCRIPTIONal
FNV58_RS36805	COG0254	rRNA binding
FNV58_RS36810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FNV58_RS36815	COG2890	protein-(glutamine-N5) methyltransferase activity
FNV58_RS36825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV58_RS36835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV58_RS36840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNV58_RS36855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FNV58_RS36860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FNV58_RS36865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FNV58_RS36870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FNV58_RS36875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FNV58_RS36880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FNV58_RS36885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FNV58_RS36900	COG2197	response regulator
FNV58_RS36925	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV58_RS36945	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FNV58_RS36990	COG1131	(ABC) transporter
FNV58_RS37010	COG0183	Belongs to the thiolase family
FNV58_RS37045	COG2814	Major facilitator Superfamily
FNV58_RS37090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS37090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS37130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FNV58_RS37135	COG0857	belongs to the CobB CobQ family
FNV58_RS37135	COG0280	phosphate acetyltransferase
FNV58_RS37140	COG0205	6-phosphofructokinase activity
FNV58_RS37155	COG0395	ABC-type sugar transport system, permease component
FNV58_RS37160	COG1175	transmembrane transport
FNV58_RS37185	COG4565	transcriptional regulatory protein
FNV58_RS37190	COG3290	protein histidine kinase activity
FNV58_RS37195	COG1301	dicarboxylic acid transport
FNV58_RS37205	COG0477	Major facilitator Superfamily
FNV58_RS37220	COG1522	sequence-specific DNA binding
FNV58_RS37240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FNV58_RS37245	COG3281	Trehalose synthase
FNV58_RS37255	COG0366	Alpha amylase catalytic
FNV58_RS37265	COG0058	SHG alpha-glucan phosphorylase activity
FNV58_RS37285	COG1132	(ABC) transporter
FNV58_RS37290	COG1132	(ABC) transporter
FNV58_RS37295	COG1132	(ABC) transporter
FNV58_RS37300	COG1132	(ABC) transporter
FNV58_RS37305	COG1131	(ABC) transporter
FNV58_RS37315	COG4585	Histidine kinase
FNV58_RS37320	COG2197	response regulator
FNV58_RS37330	COG1376	ErfK ybiS ycfS ynhG family protein
FNV58_RS37335	COG1376	ErfK ybiS ycfS ynhG family protein
FNV58_RS37385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FNV58_RS37410	COG0475	glutathione-regulated potassium exporter activity
FNV58_RS37415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS37430	COG3903	Transcriptional regulator
FNV58_RS37430	COG3629	intracellular signal transduction
FNV58_RS37435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FNV58_RS37460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS37485	COG2267	carboxylic ester hydrolase activity
FNV58_RS37490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS37495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS37500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS37505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS37515	COG4122	O-methyltransferase activity
FNV58_RS37520	COG1233	COG1233 Phytoene dehydrogenase and related
FNV58_RS37550	COG3251	PFAM MbtH domain protein
FNV58_RS37555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS37555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS37565	COG0277	FAD linked oxidase domain protein
FNV58_RS37580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FNV58_RS37585	COG1760	l-serine dehydratase
FNV58_RS37590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNV58_RS37595	COG0509	glycine decarboxylation via glycine cleavage system
FNV58_RS37600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FNV58_RS37620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV58_RS37635	COG0444	Belongs to the ABC transporter superfamily
FNV58_RS37640	COG4608	Belongs to the ABC transporter superfamily
FNV58_RS37655	COG2860	membrane
FNV58_RS37675	COG2378	regulation of single-species biofilm formation
FNV58_RS37715	COG0482	sulfurtransferase activity
FNV58_RS37725	COG1611	Belongs to the LOG family
FNV58_RS37730	COG4221	oxidoreductase activity
FNV58_RS37740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FNV58_RS37750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FNV58_RS37755	COG0154	amidase activity
FNV58_RS37765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FNV58_RS37770	COG2409	Drug exporters of the RND superfamily
FNV58_RS37775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV58_RS37790	COG2197	response regulator
FNV58_RS37800	COG2133	pyrroloquinoline quinone binding
FNV58_RS37805	COG0667	Aldo Keto reductase
FNV58_RS37815	COG5001	Diguanylate cyclase
FNV58_RS37825	COG0440	acetolactate synthase activity
FNV58_RS37830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FNV58_RS37840	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV58_RS37840	COG1672	PFAM Archaeal ATPase
FNV58_RS37845	COG0477	Major facilitator Superfamily
FNV58_RS37865	COG3214	Protein conserved in bacteria
FNV58_RS37875	COG0506	proline dehydrogenase activity
FNV58_RS37880	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS37895	COG1082	Xylose isomerase domain protein TIM barrel
FNV58_RS37905	COG0477	Major facilitator Superfamily
FNV58_RS37920	COG0473	3-isopropylmalate dehydrogenase activity
FNV58_RS37925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FNV58_RS37945	COG0831	urea catabolic process
FNV58_RS37945	COG0832	Belongs to the urease beta subunit family
FNV58_RS37950	COG0804	urea catabolic process
FNV58_RS37955	COG2957	Belongs to the agmatine deiminase family
FNV58_RS37965	COG0477	Major facilitator Superfamily
FNV58_RS37970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FNV58_RS38000	COG2197	response regulator
FNV58_RS38010	COG1131	(ABC) transporter
FNV58_RS38045	COG4585	Histidine kinase
FNV58_RS38055	COG2353	YceI-like domain
FNV58_RS38060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV58_RS38080	COG2018	Roadblock/LC7 domain
FNV58_RS38100	COG2018	Roadblock/LC7 domain
FNV58_RS38105	COG5002	protein histidine kinase activity
FNV58_RS38115	COG0179	Fumarylacetoacetate (FAA) hydrolase
FNV58_RS38120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FNV58_RS38170	COG1414	Transcriptional regulator
FNV58_RS38175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FNV58_RS38180	COG0066	3-isopropylmalate dehydratase activity
FNV58_RS38190	COG0776	regulation of translation
FNV58_RS38200	COG1920	GTP binding
FNV58_RS38210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FNV58_RS38215	COG1181	Belongs to the D-alanine--D-alanine ligase family
FNV58_RS38240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FNV58_RS38245	COG1461	Dihydroxyacetone kinase
FNV58_RS38255	COG0326	Molecular chaperone. Has ATPase activity
FNV58_RS38265	COG0742	ribosomal rna small subunit methyltransferase
FNV58_RS38270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FNV58_RS38285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FNV58_RS38290	COG0571	ribonuclease III activity
FNV58_RS38295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FNV58_RS38300	COG1733	regulation of RNA biosynthetic process
FNV58_RS38315	COG0515	serine threonine protein kinase
FNV58_RS38315	COG2815	serine threonine protein kinase
FNV58_RS38335	COG2340	Cysteine-rich secretory protein family
FNV58_RS38340	COG1254	Belongs to the acylphosphatase family
FNV58_RS38355	COG0477	Major facilitator Superfamily
FNV58_RS38395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FNV58_RS38405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FNV58_RS38415	COG0442	prolyl-tRNA aminoacylation
FNV58_RS38425	COG0228	four-way junction DNA binding
FNV58_RS38430	COG1837	Belongs to the UPF0109 family
FNV58_RS38435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FNV58_RS38440	COG0336	Belongs to the RNA methyltransferase TrmD family
FNV58_RS38445	COG0335	large ribosomal subunit rRNA binding
FNV58_RS38455	COG0681	Belongs to the peptidase S26 family
FNV58_RS38470	COG1051	belongs to the nudix hydrolase family
FNV58_RS38480	COG0792	nuclease activity
FNV58_RS38495	COG1191	sigma factor activity
FNV58_RS38510	COG0052	Belongs to the universal ribosomal protein uS2 family
FNV58_RS38515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FNV58_RS38520	COG0528	UMP kinase activity
FNV58_RS38525	COG0233	cytoplasmic translational termination
FNV58_RS38530	COG0575	Belongs to the CDS family
FNV58_RS38545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FNV58_RS38575	COG1674	ftsk spoiiie
FNV58_RS38575	COG0531	amino acid
FNV58_RS38610	COG2188	Transcriptional regulator
FNV58_RS38615	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FNV58_RS38665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FNV58_RS38675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FNV58_RS38680	COG3842	ATPase activity
FNV58_RS38710	COG1136	(ABC) transporter
FNV58_RS38715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FNV58_RS38725	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS38765	COG0477	Major facilitator Superfamily
FNV58_RS38790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV58_RS38815	COG3842	ATPase activity
FNV58_RS38820	COG1176	ABC-type spermidine putrescine transport system, permease component I
FNV58_RS38825	COG1177	transmembrane transport
FNV58_RS38830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV58_RS38860	COG2508	Transcriptional regulator
FNV58_RS38860	COG2508	Transcriptional regulator
FNV58_RS38865	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS38870	COG1472	Belongs to the glycosyl hydrolase 3 family
FNV58_RS38875	COG1653	transport
FNV58_RS38880	COG4209	transmembrane transport
FNV58_RS38885	COG0395	ABC-type sugar transport system, permease component
FNV58_RS38925	COG5297	Belongs to the glycosyl hydrolase family 6
FNV58_RS38940	COG0653	protein targeting
FNV58_RS38950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FNV58_RS38955	COG0750	zinc metalloprotease
FNV58_RS38960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FNV58_RS38975	COG0442	prolyl-tRNA aminoacylation
FNV58_RS38995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FNV58_RS39020	COG0779	Required for maturation of 30S ribosomal subunits
FNV58_RS39035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FNV58_RS39045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FNV58_RS39050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FNV58_RS39075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNV58_RS39080	COG0601	transmembrane transport
FNV58_RS39090	COG0455	bacterial-type flagellum organization
FNV58_RS39110	COG1404	Belongs to the peptidase S8 family
FNV58_RS39185	COG1674	ftsk spoiiie
FNV58_RS39200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FNV58_RS39205	COG1185	polyribonucleotide nucleotidyltransferase activity
FNV58_RS39210	COG0612	Peptidase, M16
FNV58_RS39215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FNV58_RS39235	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FNV58_RS39240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV58_RS39245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FNV58_RS39280	COG2208	phosphoserine phosphatase activity
FNV58_RS39280	COG2770	Histidine kinase
FNV58_RS39300	COG1674	ftsk spoiiie
FNV58_RS39310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FNV58_RS39320	COG1058	Belongs to the CinA family
FNV58_RS39320	COG1546	Belongs to the CinA family
FNV58_RS39325	COG1396	sequence-specific DNA binding
FNV58_RS39330	COG0783	Belongs to the Dps family
FNV58_RS39340	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS39345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FNV58_RS39350	COG1201	RNA secondary structure unwinding
FNV58_RS39380	COG0628	permease
FNV58_RS39390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FNV58_RS39410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FNV58_RS39420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS39425	COG0765	amino acid transport
FNV58_RS39430	COG0765	amino acid transport
FNV58_RS39435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV58_RS39440	COG1126	abc transporter atp-binding protein
FNV58_RS39445	COG0745	RESPONSE REGULATOR receiver
FNV58_RS39450	COG2205	protein histidine kinase activity
FNV58_RS39480	COG2197	response regulator
FNV58_RS39510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FNV58_RS39520	COG3547	Transposase (IS116 IS110 IS902 family)
FNV58_RS39535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FNV58_RS39545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FNV58_RS39550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FNV58_RS39560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FNV58_RS39600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FNV58_RS39605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FNV58_RS39610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FNV58_RS39625	COG0588	phosphoglycerate mutase activity
FNV58_RS39645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FNV58_RS39685	COG1802	Transcriptional regulator
FNV58_RS39690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FNV58_RS39705	COG0187	DNA topoisomerase II activity
FNV58_RS39720	COG2197	response regulator
FNV58_RS39730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FNV58_RS39735	COG4565	transcriptional regulatory protein
FNV58_RS39745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS39755	COG4565	transcriptional regulatory protein
FNV58_RS39760	COG3290	protein histidine kinase activity
FNV58_RS39775	COG0372	Belongs to the citrate synthase family
FNV58_RS39795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FNV58_RS39800	COG0612	Peptidase, M16
FNV58_RS39815	COG1802	Transcriptional regulator
FNV58_RS39820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNV58_RS39830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV58_RS39830	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV58_RS39830	COG1042	CoA-binding domain protein
FNV58_RS39845	COG1435	thymidine kinase activity
FNV58_RS39880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FNV58_RS39890	COG0745	RESPONSE REGULATOR receiver
FNV58_RS39895	COG2205	protein histidine kinase activity
FNV58_RS39920	COG0756	dUTP diphosphatase activity
FNV58_RS39935	COG1136	(ABC) transporter
FNV58_RS39965	COG0569	domain protein
FNV58_RS39970	COG0531	amino acid
FNV58_RS39975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FNV58_RS40035	COG4585	Histidine kinase
FNV58_RS40040	COG2409	Drug exporters of the RND superfamily
FNV58_RS40055	COG0243	molybdopterin cofactor binding
FNV58_RS40060	COG1799	cell septum assembly
FNV58_RS40090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FNV58_RS40105	COG2235	arginine
FNV58_RS40110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FNV58_RS40115	COG0531	amino acid
FNV58_RS40125	COG1024	Enoyl-CoA hydratase
FNV58_RS40170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FNV58_RS40190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FNV58_RS40200	COG1404	Belongs to the peptidase S8 family
FNV58_RS40210	COG0745	RESPONSE REGULATOR receiver
FNV58_RS40215	COG2205	protein histidine kinase activity
FNV58_RS40230	COG3537	Alpha-1,2-mannosidase
FNV58_RS40240	COG1653	transport
FNV58_RS40245	COG1175	transmembrane transport
FNV58_RS40250	COG0395	ABC-type sugar transport system, permease component
FNV58_RS40255	COG1940	carbohydrate kinase activity
FNV58_RS40260	COG4213	ABC transporter substrate-binding protein
FNV58_RS40270	COG4214	carbohydrate transport
FNV58_RS40275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FNV58_RS40280	COG0531	amino acid
FNV58_RS40315	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV58_RS40315	COG1024	Enoyl-CoA hydratase
FNV58_RS40320	COG0183	Belongs to the thiolase family
FNV58_RS40330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FNV58_RS40345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FNV58_RS40360	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV58_RS40370	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FNV58_RS40375	COG3253	May function as heme-dependent peroxidase
FNV58_RS40395	COG3220	belongs to the UPF0276 family
FNV58_RS40430	COG2326	polyphosphate kinase activity
FNV58_RS40435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FNV58_RS40475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FNV58_RS40480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNV58_RS40490	COG0515	serine threonine protein kinase
FNV58_RS40525	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
FNV58_RS40570	COG3850	Histidine kinase
FNV58_RS40570	COG3437	response regulator, receiver
FNV58_RS40570	COG2205	protein histidine kinase activity
FNV58_RS40570	COG4999	Histidine kinase
FNV58_RS40595	COG0154	amidase activity
FNV58_RS40610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV58_RS40635	COG0642	Histidine kinase
FNV58_RS40730	COG0504	CTP synthase activity
FNV58_RS40745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FNV58_RS40870	COG0667	Aldo Keto reductase
FNV58_RS40890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FNV58_RS40905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS40910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FNV58_RS40935	COG0529	Catalyzes the synthesis of activated sulfate
FNV58_RS40940	COG0175	sulfate reduction
FNV58_RS40970	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS40985	COG1917	Cupin 2, conserved barrel domain protein
FNV58_RS40985	COG4977	sequence-specific DNA binding
FNV58_RS41015	COG1609	Transcriptional regulator
FNV58_RS41045	COG0154	amidase activity
FNV58_RS41055	COG2040	homocysteine
FNV58_RS41110	COG2340	Cysteine-rich secretory protein family
FNV58_RS41115	COG0596	Alpha beta hydrolase
FNV58_RS41120	COG1309	transcriptional regulator
FNV58_RS41195	COG1131	(ABC) transporter
FNV58_RS41215	COG1175	transmembrane transport
FNV58_RS41230	COG0277	FAD linked oxidase domain protein
FNV58_RS41305	COG1162	GTPase activity
FNV58_RS41345	COG0028	Belongs to the TPP enzyme family
FNV58_RS41365	COG1802	Transcriptional regulator
FNV58_RS41395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV58_RS41400	COG2252	PERMEase
FNV58_RS41430	COG0726	polysaccharide deacetylase
FNV58_RS41435	COG0673	inositol 2-dehydrogenase activity
FNV58_RS41445	COG1132	(ABC) transporter
FNV58_RS41455	COG0596	Alpha beta hydrolase
FNV58_RS41460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS41480	COG1477	protein flavinylation
FNV58_RS41495	COG0745	RESPONSE REGULATOR receiver
FNV58_RS41500	COG2205	protein histidine kinase activity
FNV58_RS41520	COG3903	Transcriptional regulator
FNV58_RS41520	COG3629	intracellular signal transduction
FNV58_RS41530	COG3903	Transcriptional regulator
FNV58_RS41530	COG3629	intracellular signal transduction
FNV58_RS41545	COG4977	sequence-specific DNA binding
FNV58_RS41580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FNV58_RS41595	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FNV58_RS41600	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FNV58_RS41675	COG0673	inositol 2-dehydrogenase activity
FNV58_RS41680	COG0667	Aldo Keto reductase
FNV58_RS41730	COG2267	carboxylic ester hydrolase activity
FNV58_RS41750	COG0598	Magnesium transport protein CorA
FNV58_RS41765	COG0583	DNA-binding transcription factor activity
FNV58_RS41785	COG2197	response regulator
FNV58_RS41790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FNV58_RS41795	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS41805	COG3960	tartronate-semialdehyde synthase activity
FNV58_RS41815	COG0753	catalase activity
FNV58_RS41820	COG2084	Dehydrogenase
FNV58_RS41825	COG3622	Belongs to the hyi family
FNV58_RS41845	COG2351	hydroxyisourate hydrolase activity
FNV58_RS41860	COG2233	PERMEase
FNV58_RS41875	COG1733	regulation of RNA biosynthetic process
FNV58_RS41890	COG0406	alpha-ribazole phosphatase activity
FNV58_RS41895	COG0436	Aminotransferase
FNV58_RS41915	COG2304	oxidoreductase activity
FNV58_RS41920	COG4264	IucA IucC family
FNV58_RS41930	COG2815	serine threonine protein kinase
FNV58_RS41930	COG0515	serine threonine protein kinase
FNV58_RS41950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FNV58_RS41955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FNV58_RS41965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS41980	COG1414	Transcriptional regulator
FNV58_RS41985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FNV58_RS41990	COG4266	Belongs to the allantoicase family
FNV58_RS41995	COG0598	Magnesium transport protein CorA
FNV58_RS42010	COG0667	Aldo Keto reductase
FNV58_RS42015	COG2197	response regulator
FNV58_RS42025	COG0673	inositol 2-dehydrogenase activity
FNV58_RS42030	COG2188	Transcriptional regulator
FNV58_RS42055	COG1940	carbohydrate kinase activity
FNV58_RS42065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FNV58_RS42130	COG0640	Transcriptional regulator
FNV58_RS42215	COG0396	ATPase activity
FNV58_RS42230	COG0443	Heat shock 70 kDa protein
FNV58_RS42235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FNV58_RS42240	COG0484	heat shock protein binding
FNV58_RS42250	COG0542	response to heat
FNV58_RS42265	COG3634	alkyl hydroperoxide reductase activity
FNV58_RS42290	COG2826	transposase and inactivated derivatives, IS30 family
FNV58_RS42525	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FNV58_RS42545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FNV58_RS42555	COG1621	beta-fructofuranosidase activity
FNV58_RS42560	COG1609	Transcriptional regulator
FNV58_RS42565	COG1653	transport
FNV58_RS42570	COG1175	transmembrane transport
FNV58_RS42575	COG0395	ABC-type sugar transport system, permease component
FNV58_RS42580	COG1621	beta-fructofuranosidase activity
FNV58_RS42590	COG2267	carboxylic ester hydrolase activity
FNV58_RS42605	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS42620	COG1511	domain protein
FNV58_RS42630	COG0321	lipoyl(octanoyl) transferase activity
FNV58_RS42655	COG2409	Drug exporters of the RND superfamily
FNV58_RS42665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV58_RS42685	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS42730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS42770	COG4221	oxidoreductase activity
FNV58_RS42830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS42835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FNV58_RS42850	COG1126	abc transporter atp-binding protein
FNV58_RS42860	COG0765	amino acid transport
FNV58_RS42865	COG0765	amino acid transport
FNV58_RS42880	COG0405	Gamma-glutamyltransferase
FNV58_RS42920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FNV58_RS42930	COG1953	Uracil, thiamine, allantoin
FNV58_RS42940	COG2226	methyltransferase
FNV58_RS42950	COG3851	Histidine kinase
FNV58_RS42955	COG2197	response regulator
FNV58_RS42970	COG0483	inositol monophosphate 1-phosphatase activity
FNV58_RS42985	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FNV58_RS42995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FNV58_RS43000	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FNV58_RS43010	COG1215	transferase activity, transferring glycosyl groups
FNV58_RS43020	COG4310	Domain of unknown function (DUF2172)
FNV58_RS43035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FNV58_RS43045	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS43070	COG0367	asparagine synthase
FNV58_RS43090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FNV58_RS43110	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS43115	COG0583	DNA-binding transcription factor activity
FNV58_RS43125	COG0477	Major facilitator Superfamily
FNV58_RS43140	COG1309	transcriptional regulator
FNV58_RS43195	COG1136	(ABC) transporter
FNV58_RS43205	COG2205	protein histidine kinase activity
FNV58_RS43210	COG2205	protein histidine kinase activity
FNV58_RS43220	COG0671	phosphoesterase, PA-phosphatase related
FNV58_RS43240	COG0640	Transcriptional regulator
FNV58_RS43260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FNV58_RS43310	COG2130	NADP-dependent
FNV58_RS43315	COG0789	Transcriptional regulator
FNV58_RS43320	COG1192	Involved in chromosome partitioning
FNV58_RS43350	COG1929	Belongs to the glycerate kinase type-1 family
FNV58_RS43360	COG0688	phosphatidylethanolamine metabolic process
FNV58_RS43365	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS43375	COG2301	Belongs to the HpcH HpaI aldolase family
FNV58_RS43380	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS43380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FNV58_RS43385	COG0604	alcohol dehydrogenase
FNV58_RS43395	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV58_RS43405	COG0456	acetyltransferase
FNV58_RS43405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV58_RS43415	COG0596	Alpha beta hydrolase
FNV58_RS43435	COG2208	phosphoserine phosphatase activity
FNV58_RS43435	COG2172	sigma factor antagonist activity
FNV58_RS43435	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV58_RS43440	COG2226	methyltransferase
FNV58_RS43480	COG2362	D-Aminopeptidase
FNV58_RS43485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNV58_RS43495	COG1619	proteins homologs of microcin C7 resistance protein MccF
FNV58_RS43525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FNV58_RS43530	COG2226	methyltransferase
FNV58_RS43540	COG0488	(ABC) transporter
FNV58_RS43550	COG0693	protein deglycase activity
FNV58_RS43630	COG0443	Heat shock 70 kDa protein
FNV58_RS43645	COG2154	pterin-4-alpha-carbinolamine dehydratase
FNV58_RS43650	COG2226	methyltransferase
FNV58_RS43665	COG2378	regulation of single-species biofilm formation
FNV58_RS43670	COG3401	FG-GAP repeat protein
FNV58_RS43680	COG5297	Belongs to the glycosyl hydrolase family 6
FNV58_RS43680	COG4733	cellulase activity
FNV58_RS43685	COG5297	Belongs to the glycosyl hydrolase family 6
FNV58_RS43690	COG5297	Belongs to the glycosyl hydrolase family 6
FNV58_RS43710	COG4249	Peptidase C14 caspase catalytic subunit p20
FNV58_RS43710	COG2319	Wd-40 repeat
FNV58_RS43715	COG4221	oxidoreductase activity
FNV58_RS43725	COG0656	L-ascorbic acid biosynthetic process
FNV58_RS43750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FNV58_RS43760	COG3469	chitinase activity
FNV58_RS43765	COG3250	beta-galactosidase activity
FNV58_RS43775	COG0477	Major facilitator Superfamily
FNV58_RS43810	COG1846	Transcriptional regulator
FNV58_RS43815	COG1335	isochorismatase
FNV58_RS43825	COG0583	DNA-binding transcription factor activity
FNV58_RS43830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FNV58_RS43845	COG3383	formate dehydrogenase (NAD+) activity
FNV58_RS43850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FNV58_RS43860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV58_RS43895	COG1940	carbohydrate kinase activity
FNV58_RS43900	COG1129	ABC transporter
FNV58_RS43905	COG1172	Belongs to the binding-protein-dependent transport system permease family
FNV58_RS43910	COG1879	ABC-type sugar transport system periplasmic component
FNV58_RS43915	COG0673	inositol 2-dehydrogenase activity
FNV58_RS43925	COG3507	Belongs to the glycosyl hydrolase 43 family
FNV58_RS43955	COG0084	hydrolase, TatD family'
FNV58_RS43980	COG2223	nitrite transmembrane transporter activity
FNV58_RS43990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS44000	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV58_RS44010	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS44070	COG0789	Transcriptional regulator
FNV58_RS44110	COG0402	S-adenosylhomocysteine deaminase activity
FNV58_RS44140	COG2226	methyltransferase
FNV58_RS44160	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FNV58_RS44170	COG4221	oxidoreductase activity
FNV58_RS44210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNV58_RS44215	COG0254	rRNA binding
FNV58_RS44230	COG4585	Histidine kinase
FNV58_RS44235	COG2197	response regulator
FNV58_RS44270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS44275	COG2072	flavoprotein involved in K transport
FNV58_RS44295	COG0022	dehydrogenase e1 component
FNV58_RS44300	COG1309	transcriptional regulator
FNV58_RS44305	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS44310	COG1063	alcohol dehydrogenase
FNV58_RS44325	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS44330	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS44335	COG0745	RESPONSE REGULATOR receiver
FNV58_RS44390	COG0542	response to heat
FNV58_RS44420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS44430	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
FNV58_RS44445	COG1063	alcohol dehydrogenase
FNV58_RS44455	COG0745	RESPONSE REGULATOR receiver
FNV58_RS44465	COG0477	Major facilitator Superfamily
FNV58_RS44470	COG2124	cytochrome p450
FNV58_RS44490	COG0477	Major facilitator Superfamily
FNV58_RS44530	COG2353	YceI-like domain
FNV58_RS44540	COG0765	amino acid transport
FNV58_RS44545	COG1126	abc transporter atp-binding protein
FNV58_RS44550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNV58_RS44560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS44565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS44570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS44575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS44590	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV58_RS44590	COG0596	Alpha beta hydrolase
FNV58_RS44600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FNV58_RS44625	COG0438	transferase activity, transferring glycosyl groups
FNV58_RS44645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FNV58_RS44675	COG0477	Major facilitator Superfamily
FNV58_RS44685	COG3467	pyridoxamine 5'-phosphate
FNV58_RS44700	COG0477	Major facilitator Superfamily
FNV58_RS44710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FNV58_RS44715	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FNV58_RS44715	COG1082	Xylose isomerase domain protein TIM barrel
FNV58_RS44730	COG0588	phosphoglycerate mutase activity
FNV58_RS44740	COG0166	Belongs to the GPI family
FNV58_RS44755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FNV58_RS44790	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS44815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FNV58_RS44820	COG3250	beta-galactosidase activity
FNV58_RS44825	COG0395	ABC-type sugar transport system, permease component
FNV58_RS44830	COG1175	transmembrane transport
FNV58_RS44840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS44845	COG1349	DNA-binding transcription factor activity
FNV58_RS44850	COG1486	melibiose metabolic process
FNV58_RS44860	COG3469	chitinase activity
FNV58_RS44870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FNV58_RS44925	COG3842	ATPase activity
FNV58_RS44930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FNV58_RS44935	COG1176	ABC-type spermidine putrescine transport system, permease component I
FNV58_RS44940	COG1177	transmembrane transport
FNV58_RS44960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNV58_RS44965	COG3938	Belongs to the proline racemase family
FNV58_RS45000	COG1175	transmembrane transport
FNV58_RS45005	COG0395	ABC-type sugar transport system, permease component
FNV58_RS45010	COG0366	Alpha amylase catalytic
FNV58_RS45020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS45025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS45130	COG3511	phospholipase C
FNV58_RS45205	COG0494	nUDIX hydrolase
FNV58_RS45285	COG3328	transposase activity
FNV58_RS45295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FNV58_RS45300	COG0477	Major facilitator Superfamily
FNV58_RS45315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS45325	COG3485	protocatechuate 3,4-dioxygenase
FNV58_RS45330	COG3485	protocatechuate 3,4-dioxygenase
FNV58_RS45335	COG0183	Belongs to the thiolase family
FNV58_RS45350	COG1846	Transcriptional regulator
FNV58_RS45360	COG0714	Associated with various cellular activities
FNV58_RS45375	COG1793	dna ligase
FNV58_RS45455	COG1834	amidinotransferase
FNV58_RS45460	COG0488	(ABC) transporter
FNV58_RS45470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FNV58_RS45490	COG1515	deoxyribonuclease V activity
FNV58_RS45495	COG3268	Saccharopine dehydrogenase
FNV58_RS45500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS45505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS45515	COG0183	Belongs to the thiolase family
FNV58_RS45520	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV58_RS45520	COG1024	Enoyl-CoA hydratase
FNV58_RS45525	COG0789	Transcriptional regulator
FNV58_RS45530	COG1113	amino acid transport
FNV58_RS45540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FNV58_RS45550	COG2936	dipeptidyl-peptidase activity
FNV58_RS45565	COG0488	(ABC) transporter
FNV58_RS45575	COG2183	response to ionizing radiation
FNV58_RS45585	COG4977	sequence-specific DNA binding
FNV58_RS45595	COG1024	Enoyl-CoA hydratase
FNV58_RS45610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FNV58_RS45615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FNV58_RS45615	COG4106	trans-aconitate 2-methyltransferase activity
FNV58_RS45660	COG1134	teichoic acid transport
FNV58_RS45665	COG1562	ergosterol biosynthetic process
FNV58_RS45675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FNV58_RS45685	COG1657	PFAM Prenyltransferase squalene oxidase
FNV58_RS45700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FNV58_RS45705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FNV58_RS45725	COG2365	Tyrosine phosphatase family
FNV58_RS45740	COG3401	FG-GAP repeat protein
FNV58_RS45750	COG2755	lipolytic protein G-D-S-L family
FNV58_RS45765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FNV58_RS45810	COG1063	alcohol dehydrogenase
FNV58_RS45815	COG0156	8-amino-7-oxononanoate synthase activity
FNV58_RS45820	COG0583	DNA-binding transcription factor activity
FNV58_RS45855	COG3958	Transketolase
FNV58_RS45860	COG3959	Transketolase, thiamine diphosphate binding domain
FNV58_RS45885	COG1132	(ABC) transporter
FNV58_RS45915	COG3033	Beta-eliminating lyase
FNV58_RS45935	COG1937	Protein conserved in bacteria
FNV58_RS45955	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FNV58_RS45975	COG3239	Fatty acid desaturase
FNV58_RS45985	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FNV58_RS46090	COG1454	alcohol dehydrogenase
FNV58_RS46100	COG0351	phosphomethylpyrimidine kinase
FNV58_RS46105	COG0702	epimerase
FNV58_RS46155	COG1595	DNA-templated transcription, initiation
FNV58_RS46165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV58_RS46180	COG1053	succinate dehydrogenase
FNV58_RS46185	COG1764	response to oxidative stress
FNV58_RS46190	COG1595	DNA-templated transcription, initiation
FNV58_RS46250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS46275	COG2838	Isocitrate dehydrogenase
FNV58_RS46280	COG0668	transmembrane transport
FNV58_RS46285	COG1024	Enoyl-CoA hydratase
FNV58_RS46300	COG2409	Drug exporters of the RND superfamily
FNV58_RS46305	COG1309	transcriptional regulator
FNV58_RS46310	COG0473	3-isopropylmalate dehydrogenase activity
FNV58_RS46320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS46335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FNV58_RS46350	COG3483	tryptophan 2,3-dioxygenase activity
FNV58_RS46365	COG0475	glutathione-regulated potassium exporter activity
FNV58_RS46370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FNV58_RS46385	COG2264	protein methyltransferase activity
FNV58_RS46415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FNV58_RS46430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNV58_RS46435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FNV58_RS46440	COG0697	spore germination
FNV58_RS46445	COG1509	lysine 2,3-aminomutase activity
FNV58_RS46455	COG0579	oxidoreductase
FNV58_RS46505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FNV58_RS46525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FNV58_RS46545	COG0297	glycogen (starch) synthase activity
FNV58_RS46550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FNV58_RS46570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV58_RS46575	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS46585	COG0701	Predicted permease
FNV58_RS46625	COG1175	transmembrane transport
FNV58_RS46630	COG0395	ABC-type sugar transport system, permease component
FNV58_RS46650	COG2186	Transcriptional regulator
FNV58_RS46655	COG1879	ABC-type sugar transport system periplasmic component
FNV58_RS46660	COG1129	ABC transporter
FNV58_RS46665	COG1172	Belongs to the binding-protein-dependent transport system permease family
FNV58_RS46670	COG4948	Mandelate Racemase Muconate Lactonizing
FNV58_RS46675	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS46710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FNV58_RS46745	COG0726	polysaccharide deacetylase
FNV58_RS46795	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS46810	COG1053	succinate dehydrogenase
FNV58_RS46815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FNV58_RS46835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS46850	COG0667	Aldo Keto reductase
FNV58_RS46885	COG1595	DNA-templated transcription, initiation
FNV58_RS46925	COG2814	Major facilitator Superfamily
FNV58_RS46930	COG0583	DNA-binding transcription factor activity
FNV58_RS46935	COG0583	DNA-binding transcription factor activity
FNV58_RS46950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV58_RS46955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FNV58_RS46960	COG2080	2 iron, 2 sulfur cluster binding
FNV58_RS46975	COG0667	Aldo Keto reductase
FNV58_RS47005	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FNV58_RS47010	COG0121	glutamine amidotransferase
FNV58_RS47015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FNV58_RS47020	COG3572	ergothioneine biosynthetic process
FNV58_RS47040	COG2268	Band 7 protein
FNV58_RS47055	COG1609	Transcriptional regulator
FNV58_RS47070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FNV58_RS47080	COG0242	peptide deformylase activity
FNV58_RS47160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV58_RS47175	COG1408	metallophosphoesterase
FNV58_RS47180	COG2226	methyltransferase
FNV58_RS47230	COG2378	regulation of single-species biofilm formation
FNV58_RS47255	COG1609	Transcriptional regulator
FNV58_RS47270	COG0395	ABC-type sugar transport system, permease component
FNV58_RS47305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FNV58_RS47325	COG1309	transcriptional regulator
FNV58_RS47330	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS47365	COG0163	prenyltransferase activity
FNV58_RS47400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FNV58_RS47420	COG2318	DinB family
FNV58_RS47440	COG1733	regulation of RNA biosynthetic process
FNV58_RS47450	COG2366	antibiotic biosynthetic process
FNV58_RS47455	COG1073	alpha beta
FNV58_RS47505	COG0583	DNA-binding transcription factor activity
FNV58_RS47510	COG2130	NADP-dependent
FNV58_RS47535	COG2072	flavoprotein involved in K transport
FNV58_RS47540	COG0667	Aldo Keto reductase
FNV58_RS47545	COG1902	pentaerythritol trinitrate reductase activity
FNV58_RS47565	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS47580	COG0183	Belongs to the thiolase family
FNV58_RS47600	COG3485	protocatechuate 3,4-dioxygenase
FNV58_RS47610	COG2909	trisaccharide binding
FNV58_RS47635	COG0778	Nitroreductase
FNV58_RS47690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FNV58_RS47710	COG3537	Alpha-1,2-mannosidase
FNV58_RS47725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS47745	COG0477	Major facilitator Superfamily
FNV58_RS47765	COG0006	proline dipeptidase activity
FNV58_RS47770	COG3291	Pkd domain containing protein
FNV58_RS47780	COG0673	inositol 2-dehydrogenase activity
FNV58_RS47795	COG1609	Transcriptional regulator
FNV58_RS47800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FNV58_RS47835	COG1122	ATPase activity
FNV58_RS47840	COG1122	ATPase activity
FNV58_RS47845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FNV58_RS47870	COG0561	phosphatase activity
FNV58_RS47945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FNV58_RS47950	COG2151	metal-sulfur cluster biosynthetic enzyme
FNV58_RS47955	COG3396	Phenylacetate-CoA oxygenase
FNV58_RS47960	COG3460	Phenylacetate-CoA oxygenase
FNV58_RS47965	COG3396	Phenylacetate-CoA oxygenase
FNV58_RS47970	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNV58_RS47990	COG2050	protein possibly involved in aromatic compounds catabolism
FNV58_RS48005	COG0531	amino acid
FNV58_RS48075	COG2226	methyltransferase
FNV58_RS48100	COG1024	Enoyl-CoA hydratase
FNV58_RS48100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FNV58_RS48110	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FNV58_RS48140	COG0375	protein maturation
FNV58_RS48145	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FNV58_RS48150	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FNV58_RS48155	COG0298	carbon dioxide binding
FNV58_RS48160	COG0409	Hydrogenase expression formation protein
FNV58_RS48165	COG0309	Hydrogenase expression formation protein (HypE)
FNV58_RS48195	COG1141	Ferredoxin
FNV58_RS48225	COG1136	(ABC) transporter
FNV58_RS48230	COG1174	glycine betaine transport
FNV58_RS48235	COG1174	glycine betaine transport
FNV58_RS48255	COG0517	IMP dehydrogenase activity
FNV58_RS48255	COG1125	glycine betaine transport
FNV58_RS48260	COG1556	Lactate utilization protein
FNV58_RS48265	COG1139	Iron-sulfur cluster binding protein
FNV58_RS48270	COG0247	lactate metabolic process
FNV58_RS48275	COG1070	Carbohydrate kinase
FNV58_RS48280	COG3347	Dehydrogenase
FNV58_RS48280	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS48290	COG1129	ABC transporter
FNV58_RS48325	COG1609	Transcriptional regulator
FNV58_RS48335	COG1595	DNA-templated transcription, initiation
FNV58_RS48340	COG1357	PFAM Pentapeptide repeats (8 copies)
FNV58_RS48350	COG1309	transcriptional regulator
FNV58_RS48360	COG2706	6-phosphogluconolactonase activity
FNV58_RS48385	COG3321	synthase
FNV58_RS48385	COG0604	alcohol dehydrogenase
FNV58_RS48385	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS48410	COG2723	6-phospho-beta-galactosidase activity
FNV58_RS48415	COG0395	ABC-type sugar transport system, permease component
FNV58_RS48420	COG1175	transmembrane transport
FNV58_RS48425	COG2182	Extracellular solute-binding protein
FNV58_RS48450	COG2267	carboxylic ester hydrolase activity
FNV58_RS48460	COG1796	DNA polymerase
FNV58_RS48460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FNV58_RS48510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNV58_RS48535	COG0515	serine threonine protein kinase
FNV58_RS48585	COG0640	Transcriptional regulator
FNV58_RS48595	COG0772	Belongs to the SEDS family
FNV58_RS48630	COG1316	TRANSCRIPTIONal
FNV58_RS48640	COG1278	Cold shock
FNV58_RS48675	COG0515	serine threonine protein kinase
FNV58_RS48685	COG1132	(ABC) transporter
FNV58_RS48690	COG1132	(ABC) transporter
FNV58_RS48695	COG2197	response regulator
FNV58_RS48700	COG0531	amino acid
FNV58_RS48810	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FNV58_RS48810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS48835	COG1609	Transcriptional regulator
FNV58_RS48860	COG1621	beta-fructofuranosidase activity
FNV58_RS48940	COG1366	Belongs to the anti-sigma-factor antagonist family
FNV58_RS48940	COG2172	sigma factor antagonist activity
FNV58_RS48940	COG2208	phosphoserine phosphatase activity
FNV58_RS48955	COG0789	Transcriptional regulator
FNV58_RS48970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FNV58_RS49065	COG2318	DinB family
FNV58_RS49095	COG0745	RESPONSE REGULATOR receiver
FNV58_RS49155	COG2132	Multicopper oxidase
FNV58_RS49165	COG2226	methyltransferase
FNV58_RS49180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FNV58_RS49200	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS49240	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS49250	COG0531	amino acid
FNV58_RS49290	COG2124	cytochrome p450
FNV58_RS49330	COG0596	Alpha beta hydrolase
FNV58_RS49335	COG1672	PFAM Archaeal ATPase
FNV58_RS49335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FNV58_RS49365	COG3250	beta-galactosidase activity
FNV58_RS49370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FNV58_RS49395	COG0640	Transcriptional regulator
FNV58_RS49430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FNV58_RS49445	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FNV58_RS49460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS49475	COG4209	transmembrane transport
FNV58_RS49480	COG0395	ABC-type sugar transport system, permease component
FNV58_RS49490	COG1609	Transcriptional regulator
FNV58_RS49505	COG0671	phosphoesterase, PA-phosphatase related
FNV58_RS49520	COG3832	glyoxalase III activity
FNV58_RS49565	COG2755	lipolytic protein G-D-S-L family
FNV58_RS49565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV58_RS49580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FNV58_RS49630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FNV58_RS49645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FNV58_RS49660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FNV58_RS49685	COG1132	(ABC) transporter
FNV58_RS49730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS49765	COG1846	Transcriptional regulator
FNV58_RS49765	COG1940	carbohydrate kinase activity
FNV58_RS49785	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FNV58_RS49810	COG1595	DNA-templated transcription, initiation
FNV58_RS49855	COG4948	Mandelate Racemase Muconate Lactonizing
FNV58_RS49865	COG0583	DNA-binding transcription factor activity
FNV58_RS49915	COG1404	Belongs to the peptidase S8 family
FNV58_RS49935	COG2318	DinB family
FNV58_RS49970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV58_RS49975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FNV58_RS49985	COG2409	Drug exporters of the RND superfamily
FNV58_RS50015	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS50020	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS50080	COG1802	Transcriptional regulator
FNV58_RS50140	COG0384	phenazine biosynthesis protein PhzF
FNV58_RS50150	COG0583	DNA-binding transcription factor activity
FNV58_RS50175	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS50225	COG1278	Cold shock
FNV58_RS50250	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FNV58_RS50255	COG0714	Associated with various cellular activities
FNV58_RS50285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FNV58_RS50295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV58_RS50305	COG0596	Alpha beta hydrolase
FNV58_RS50320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FNV58_RS50335	COG1940	carbohydrate kinase activity
FNV58_RS50345	COG1175	transmembrane transport
FNV58_RS50350	COG0395	ABC-type sugar transport system, permease component
FNV58_RS50375	COG2340	Cysteine-rich secretory protein family
FNV58_RS50420	COG3469	chitinase activity
FNV58_RS50430	COG3548	integral membrane protein
FNV58_RS50440	COG0667	Aldo Keto reductase
FNV58_RS50455	COG3537	Alpha-1,2-mannosidase
FNV58_RS50480	COG1129	ABC transporter
FNV58_RS50500	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS50505	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS50510	COG1024	Enoyl-CoA hydratase
FNV58_RS50520	COG0183	Belongs to the thiolase family
FNV58_RS50525	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS50535	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS50540	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS50545	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS50550	COG1024	Enoyl-CoA hydratase
FNV58_RS50580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS50595	COG1228	amidohydrolase
FNV58_RS50600	COG0515	serine threonine protein kinase
FNV58_RS50610	COG3250	beta-galactosidase activity
FNV58_RS50645	COG0730	response to heat
FNV58_RS50650	COG1937	Protein conserved in bacteria
FNV58_RS50690	COG1175	transmembrane transport
FNV58_RS50715	COG3345	alpha-galactosidase
FNV58_RS50725	COG0667	Aldo Keto reductase
FNV58_RS50730	COG1335	isochorismatase
FNV58_RS50750	COG3852	Histidine kinase
FNV58_RS50755	COG0492	ferredoxin-NADP+ reductase activity
FNV58_RS50785	COG3290	protein histidine kinase activity
FNV58_RS50795	COG2814	Major facilitator Superfamily
FNV58_RS50820	COG1716	ATPase activity
FNV58_RS50820	COG1131	(ABC) transporter
FNV58_RS50820	COG0842	Transport permease protein
FNV58_RS50855	COG0739	heme binding
FNV58_RS50875	COG0583	DNA-binding transcription factor activity
FNV58_RS50880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FNV58_RS50900	COG2197	response regulator
FNV58_RS50920	COG0395	ABC-type sugar transport system, permease component
FNV58_RS50935	COG1335	isochorismatase
FNV58_RS50950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FNV58_RS50970	COG5002	protein histidine kinase activity
FNV58_RS50980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FNV58_RS50985	COG1053	succinate dehydrogenase
FNV58_RS50995	COG2318	DinB family
FNV58_RS51005	COG2318	DinB family
FNV58_RS51050	COG0596	Alpha beta hydrolase
FNV58_RS51055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FNV58_RS51055	COG1017	nitric oxide dioxygenase activity
FNV58_RS51080	COG1595	DNA-templated transcription, initiation
FNV58_RS51100	COG0745	RESPONSE REGULATOR receiver
FNV58_RS51130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FNV58_RS51140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FNV58_RS51140	COG2080	2 iron, 2 sulfur cluster binding
FNV58_RS51165	COG2197	response regulator
FNV58_RS51190	COG4191	Histidine kinase
FNV58_RS51200	COG0517	IMP dehydrogenase activity
FNV58_RS51200	COG0516	GMP reductase activity
FNV58_RS51250	COG0589	response to stress
FNV58_RS51255	COG2326	polyphosphate kinase activity
FNV58_RS51260	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FNV58_RS51265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FNV58_RS51285	COG1042	CoA-binding domain protein
FNV58_RS51285	COG0045	succinate-CoA ligase (ADP-forming) activity
FNV58_RS51285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FNV58_RS51310	COG0516	GMP reductase activity
FNV58_RS51310	COG0517	IMP dehydrogenase activity
FNV58_RS51325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FNV58_RS51325	COG0574	Belongs to the PEP-utilizing enzyme family
FNV58_RS51365	COG0516	GMP reductase activity
FNV58_RS51365	COG0517	IMP dehydrogenase activity
FNV58_RS51385	COG2239	Acts as a magnesium transporter
FNV58_RS51445	COG1063	alcohol dehydrogenase
FNV58_RS51460	COG0531	amino acid
FNV58_RS51465	COG2235	arginine
FNV58_RS51470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FNV58_RS51475	COG0549	Belongs to the carbamate kinase family
FNV58_RS51485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FNV58_RS51515	COG1309	transcriptional regulator
FNV58_RS51520	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS51535	COG1278	Cold shock
FNV58_RS51540	COG0513	Belongs to the DEAD box helicase family
FNV58_RS51590	COG2274	protein secretion by the type I secretion system
FNV58_RS51635	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FNV58_RS51640	COG2226	methyltransferase
FNV58_RS51645	COG5640	endopeptidase activity
FNV58_RS51660	COG0789	Transcriptional regulator
FNV58_RS51690	COG1132	(ABC) transporter
FNV58_RS51700	COG2318	DinB family
FNV58_RS51720	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS51725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FNV58_RS51730	COG1414	Transcriptional regulator
FNV58_RS51745	COG4106	trans-aconitate 2-methyltransferase activity
FNV58_RS51775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS51780	COG1335	isochorismatase
FNV58_RS51810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNV58_RS51875	COG2208	phosphoserine phosphatase activity
FNV58_RS51890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV58_RS51925	COG0583	DNA-binding transcription factor activity
FNV58_RS51930	COG0243	molybdopterin cofactor binding
FNV58_RS51965	COG2837	iron assimilation
FNV58_RS51975	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS51980	COG0657	acetylesterase activity
FNV58_RS51990	COG2207	Transcriptional regulator
FNV58_RS52000	COG0745	RESPONSE REGULATOR receiver
FNV58_RS52005	COG2205	protein histidine kinase activity
FNV58_RS52105	COG1309	transcriptional regulator
FNV58_RS52120	COG1309	transcriptional regulator
FNV58_RS52125	COG1064	alcohol dehydrogenase
FNV58_RS52140	COG1172	Belongs to the binding-protein-dependent transport system permease family
FNV58_RS52145	COG1129	ABC transporter
FNV58_RS52155	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS52210	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS52215	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS52245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FNV58_RS52260	COG1522	sequence-specific DNA binding
FNV58_RS52310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS52335	COG1595	DNA-templated transcription, initiation
FNV58_RS52365	COG2267	carboxylic ester hydrolase activity
FNV58_RS52380	COG0531	amino acid
FNV58_RS52390	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS52395	COG4221	oxidoreductase activity
FNV58_RS52420	COG4941	Belongs to the sigma-70 factor family
FNV58_RS52425	COG3795	YCII-related domain
FNV58_RS52470	COG1309	transcriptional regulator
FNV58_RS52475	COG0667	Aldo Keto reductase
FNV58_RS52505	COG2124	cytochrome p450
FNV58_RS52530	COG4585	Histidine kinase
FNV58_RS52535	COG2197	response regulator
FNV58_RS52565	COG2197	response regulator
FNV58_RS52570	COG4585	Histidine kinase
FNV58_RS52575	COG4552	Acetyltransferase involved in intracellular survival and related
FNV58_RS52615	COG0596	Alpha beta hydrolase
FNV58_RS52635	COG2197	response regulator
FNV58_RS52650	COG1902	pentaerythritol trinitrate reductase activity
FNV58_RS52650	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV58_RS52655	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS52660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNV58_RS52670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FNV58_RS52685	COG0583	DNA-binding transcription factor activity
FNV58_RS52690	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS52710	COG0745	RESPONSE REGULATOR receiver
FNV58_RS52810	COG1309	transcriptional regulator
FNV58_RS52820	COG1309	transcriptional regulator
FNV58_RS52860	COG3173	Aminoglycoside phosphotransferase
FNV58_RS52885	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS52915	COG3321	synthase
FNV58_RS52915	COG0604	alcohol dehydrogenase
FNV58_RS52965	COG0326	Molecular chaperone. Has ATPase activity
FNV58_RS52975	COG2409	Drug exporters of the RND superfamily
FNV58_RS52990	COG2072	flavoprotein involved in K transport
FNV58_RS53000	COG1012	belongs to the aldehyde dehydrogenase family
FNV58_RS53075	COG4977	sequence-specific DNA binding
FNV58_RS53095	COG1024	Enoyl-CoA hydratase
FNV58_RS53140	COG0446	pyridine nucleotide-disulphide oxidoreductase
FNV58_RS53140	COG1902	pentaerythritol trinitrate reductase activity
FNV58_RS53155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FNV58_RS53160	COG4221	oxidoreductase activity
FNV58_RS53170	COG0477	Major facilitator Superfamily
FNV58_RS53185	COG0477	Major facilitator Superfamily
FNV58_RS53190	COG0477	Major facilitator Superfamily
FNV58_RS53210	COG1609	Transcriptional regulator
FNV58_RS53235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNV58_RS53240	COG0667	Aldo Keto reductase
FNV58_RS53275	COG0300	oxidoreductase activity
FNV58_RS53285	COG1309	transcriptional regulator
FNV58_RS53310	COG1802	Transcriptional regulator
FNV58_RS53315	COG2205	protein histidine kinase activity
FNV58_RS53320	COG0745	RESPONSE REGULATOR receiver
FNV58_RS53325	COG2409	Drug exporters of the RND superfamily
FNV58_RS53410	COG2261	transglycosylase associated protein
FNV58_RS53415	COG0640	Transcriptional regulator
FNV58_RS53425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV58_RS53440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FNV58_RS53495	COG0179	Fumarylacetoacetate (FAA) hydrolase
FNV58_RS53510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FNV58_RS53535	COG0202	RNA polymerase activity
FNV58_RS53550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNV58_RS53600	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FNV58_RS53635	COG4977	sequence-specific DNA binding
FNV58_RS53650	COG0477	Major facilitator Superfamily
FNV58_RS53690	COG4585	Histidine kinase
FNV58_RS53695	COG2197	response regulator
FNV58_RS53705	COG2272	Belongs to the type-B carboxylesterase lipase family
FNV58_RS53750	COG2208	phosphoserine phosphatase activity
FNV58_RS53750	COG2770	Histidine kinase
FNV58_RS53895	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FNV58_RS53940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNV58_RS53940	COG3321	synthase
FNV58_RS53940	COG4221	oxidoreductase activity
FNV58_RS53940	COG0604	alcohol dehydrogenase
FNV58_RS53965	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS54035	COG4585	Histidine kinase
FNV58_RS54060	COG2135	peptidase activity
FNV58_RS54225	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FNV58_RS54270	COG3118	belongs to the thioredoxin family
FNV58_RS54320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNV58_RS54325	COG0483	inositol monophosphate 1-phosphatase activity
FNV58_RS54330	COG0583	DNA-binding transcription factor activity
FNV58_RS54355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FNV58_RS54380	COG0563	adenylate kinase activity
FNV58_RS54420	COG2159	amidohydrolase
FNV58_RS54445	COG2226	methyltransferase
FNV58_RS54450	COG3328	transposase activity
FNV58_RS54490	COG2197	response regulator
FNV58_RS54585	COG4584	PFAM Integrase catalytic
FNV58_RS54590	COG1484	DNA-dependent DNA replication
FNV58_RS54705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FNV58_RS54725	COG4221	oxidoreductase activity
FNV58_RS54725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS54725	COG3321	synthase
FNV58_RS54725	COG0300	oxidoreductase activity
FNV58_RS54745	COG0318	PFAM AMP-dependent synthetase and ligase
FNV58_RS54750	COG2197	response regulator
FNV58_RS54775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FNV58_RS54780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNV58_RS54785	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS54790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FNV58_RS54795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS54800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FNV58_RS54805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS54810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNV58_RS54815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNV58_RS54825	COG0667	Aldo Keto reductase
FNV58_RS54840	COG1022	Amp-dependent synthetase and ligase
FNV58_RS54865	COG0477	Major facilitator Superfamily
FNV58_RS54870	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FNV58_RS54960	COG1335	isochorismatase
FNV58_RS54965	COG3619	membrane
FNV58_RS55005	COG3547	Transposase (IS116 IS110 IS902 family)
FNV58_RS55050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FNV58_RS55070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FNV58_RS55130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNV58_RS55135	COG3387	PFAM Glycoside hydrolase 15-related
FNV58_RS55140	COG3547	Transposase (IS116 IS110 IS902 family)
FNV58_RS55145	COG2197	response regulator
FNV58_RS55150	COG4585	Histidine kinase
FNV58_RS55180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FNV58_RS55185	COG1595	DNA-templated transcription, initiation
FNV58_RS55250	COG0248	Ppx GppA phosphatase
FNV58_RS55360	COG3321	synthase
FNV58_RS55360	COG0604	alcohol dehydrogenase
FNV58_RS55365	COG0657	acetylesterase activity
FNV58_RS55435	COG4977	sequence-specific DNA binding
FNV58_RS55500	COG2207	Transcriptional regulator
FNV58_RS55520	COG2801	Transposase and inactivated derivatives
FNV58_RS55525	COG2826	transposase and inactivated derivatives, IS30 family
FNV58_RS55620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FNV58_RS55665	COG1960	acyl-CoA dehydrogenase activity
FNV58_RS55670	COG1454	alcohol dehydrogenase
FNV58_RS55685	COG0583	DNA-binding transcription factor activity
FNV58_RS55690	COG0183	Belongs to the thiolase family
FNV58_RS55700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FNV58_RS55715	COG0006	proline dipeptidase activity
FNV58_RS55720	COG2084	Dehydrogenase
FNV58_RS55735	COG1609	Transcriptional regulator
FNV58_RS55740	COG2188	Transcriptional regulator
FNV58_RS55750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FNV58_RS55755	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNV58_RS55780	COG1609	Transcriptional regulator
FNV58_RS55805	COG1131	(ABC) transporter
FNV58_RS55830	COG1335	isochorismatase
FNV58_RS55835	COG3619	membrane
FNV58_RS55870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FNV58_RS55880	COG1116	anion transmembrane transporter activity
FNV58_RS55890	COG2353	YceI-like domain
FNV58_RS55895	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS55990	COG3328	transposase activity
FNV58_RS55995	COG3328	transposase activity
FNV58_RS56005	COG0069	glutamate synthase activity
FNV58_RS56070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNV58_RS56075	COG1028	Short-chain dehydrogenase reductase Sdr
FNV58_RS56095	COG0477	Major facilitator Superfamily
FNV58_RS56105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FNV58_RS56110	COG1024	Enoyl-CoA hydratase