locus-tag class description HEP85_RS00005 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HEP85_RS00090 ENOG4108JDX DNA polymerase iii, epsilon subunit HEP85_RS00115 ENOG4105CIR epoxide hydrolase HEP85_RS00145 ENOG4105I6B RNA polymerase HEP85_RS00155 ENOG4105E0X reductase HEP85_RS00200 ENOG4105K56 Transcriptional regulator HEP85_RS00315 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HEP85_RS00465 ENOG4108MP6 LysR family Transcriptional regulator HEP85_RS00490 ENOG4105C1J atp-dependent rna helicase HEP85_RS00500 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HEP85_RS00525 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HEP85_RS00535 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS00540 ENOG4105C0W non-ribosomal peptide synthetase HEP85_RS00550 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HEP85_RS00555 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS00570 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HEP85_RS00575 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HEP85_RS00640 ENOG4106A3M Cytochrome p-450 HEP85_RS00670 ENOG4107SQU synthase HEP85_RS00680 ENOG4105E63 Pfam:DUF178 HEP85_RS00685 ENOG4105DVY radical SAM domain protein HEP85_RS00700 ENOG4105EV6 Pfam:DUF178 HEP85_RS00720 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS00810 ENOG4108JA1 polyketide synthase HEP85_RS00850 ENOG4108JA1 polyketide synthase HEP85_RS00865 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HEP85_RS00960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP85_RS00970 ENOG4107P5I polyketide synthase HEP85_RS01005 ENOG4105D5P Methylmalonyl-coA mutase HEP85_RS01045 ENOG4105BZP glycoside hydrolase 15-related HEP85_RS01060 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS01065 ENOG4105C9B Cysteine desulfurase HEP85_RS01085 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HEP85_RS01100 ENOG4105EZE Cupin 4 family protein HEP85_RS01235 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HEP85_RS01255 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEP85_RS01285 ENOG4108IQE Amp-dependent synthetase and ligase HEP85_RS01300 ENOG4105CPC Aldo Keto reductase HEP85_RS01310 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP85_RS01320 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEP85_RS01340 ENOG4105CHR reductase HEP85_RS01345 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP85_RS01375 ENOG4105NX3 Membrane HEP85_RS01420 ENOG4105D8K carboxyl transferase HEP85_RS01475 ENOG41064MX Tetr family transcriptional regulator HEP85_RS01490 ENOG4105CHR reductase HEP85_RS01505 ENOG4107R13 MMPL domain protein HEP85_RS01515 ENOG4105CIR epoxide hydrolase HEP85_RS01525 ENOG4105NPE arsR family transcriptional regulator HEP85_RS01530 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HEP85_RS01540 ENOG4105ENX hydrolase HEP85_RS01550 ENOG4105D74 hydrolase HEP85_RS01600 ENOG4105C54 Major Facilitator superfamily HEP85_RS01620 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS01665 ENOG4105CHR reductase HEP85_RS01710 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP85_RS01735 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP85_RS01755 ENOG4105ECQ AraC Family Transcriptional Regulator HEP85_RS01770 ENOG4106A3M Cytochrome p-450 HEP85_RS01775 ENOG4105DQE DNA ligase HEP85_RS01830 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP85_RS01885 ENOG4105CHR reductase HEP85_RS01890 ENOG4105FP9 thiamine pyrophosphate HEP85_RS01895 ENOG4105DMF Dehydrogenase HEP85_RS01915 ENOG4105EXC Acyl-transferase HEP85_RS01925 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP85_RS01965 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HEP85_RS01980 ENOG4108IND Tetr family transcriptional regulator HEP85_RS01990 ENOG4105DC8 reductase HEP85_RS02030 ENOG4108XFH Transcriptional regulator HEP85_RS02065 ENOG4105I6B RNA polymerase HEP85_RS02070 ENOG4105EV9 Alpha Beta Hydrolase HEP85_RS02075 ENOG4105GRZ Ycii-related protein HEP85_RS02090 ENOG4107R6F Alpha Beta Hydrolase Fold protein HEP85_RS02165 ENOG41061H0 Monooxygenase HEP85_RS02180 ENOG4107SCK Monooxygenase HEP85_RS02190 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HEP85_RS02210 ENOG4105EMU Dehydrogenase HEP85_RS02215 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HEP85_RS02220 ENOG4106KNT transcriptional regulator HEP85_RS02230 ENOG4107RJ1 sodium solute HEP85_RS02255 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP85_RS02260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP85_RS02265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS02280 ENOG4105DKQ ROK family HEP85_RS02290 ENOG4105DTQ mandelate racemase muconate lactonizing HEP85_RS02295 ENOG4105KME endoribonuclease L-psp HEP85_RS02325 ENOG4105CHR reductase HEP85_RS02350 ENOG4105C3J Cysteine desulfurase HEP85_RS02360 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP85_RS02365 ENOG4105QAX Iron-sulfur HEP85_RS02375 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HEP85_RS02390 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HEP85_RS02425 ENOG4105DRS transport system, permease HEP85_RS02440 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS02450 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP85_RS02455 ENOG4108KPJ rna polymerase sigma factor HEP85_RS02475 ENOG4105CPC Aldo Keto reductase HEP85_RS02485 ENOG4108Z6Z Transcriptional regulator HEP85_RS02495 ENOG4105BZ1 (ABC) transporter HEP85_RS02535 ENOG4105ESN nucleotide-binding protein HEP85_RS02555 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS02565 ENOG4105D56 permease protein HEP85_RS02570 ENOG4105DRS transport system, permease HEP85_RS02590 ENOG4105F0V Cell wall hydrolase HEP85_RS02595 ENOG4105DGI Alkaline phosphatase HEP85_RS02605 ENOG4105EA8 2-Nitropropane dioxygenase HEP85_RS02635 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HEP85_RS02685 ENOG41082AN stage II sporulation protein HEP85_RS02690 ENOG4105C7K acetolactate synthase HEP85_RS02695 ENOG4105CBC glutamate synthase HEP85_RS02715 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP85_RS02745 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP85_RS02750 ENOG4108Z40 Transcriptional regulator HEP85_RS02755 ENOG4107RTG Major Facilitator superfamily HEP85_RS02760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP85_RS02775 ENOG4105M4P Tetr family transcriptional regulator HEP85_RS02780 ENOG4108Z40 Transcriptional regulator HEP85_RS02785 ENOG4105EMN RNA polymerase sigma factor HEP85_RS02820 ENOG4105K4I Scp-like extracellular HEP85_RS02830 ENOG4105EMU Dehydrogenase HEP85_RS02835 ENOG4107RSM transcriptional regulator HEP85_RS02870 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS02890 ENOG4105CWX Alpha-1,2-mannosidase HEP85_RS02905 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS02945 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HEP85_RS02970 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEP85_RS02980 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP85_RS03075 ENOG4105CG3 alpha amylase, catalytic region HEP85_RS03080 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP85_RS03100 ENOG4105CF7 AraC family transcriptional regulator HEP85_RS03130 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP85_RS03150 ENOG4106UDK Cellulose-binding, family II HEP85_RS03155 ENOG4105EGE secreted protein HEP85_RS03180 ENOG4105BZU Histidine kinase HEP85_RS03185 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS03220 ENOG4107QN1 sodium solute HEP85_RS03255 ENOG4105BZU Histidine kinase HEP85_RS03260 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS03265 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEP85_RS03285 ENOG4105YA8 Transcriptional regulator HEP85_RS03315 ENOG4105EW6 flavin reductase domain protein, FMN-binding HEP85_RS03395 ENOG4108KGH TRANSCRIPTIONal HEP85_RS03400 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEP85_RS03430 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HEP85_RS03440 ENOG41080V3 Major Facilitator superfamily HEP85_RS03445 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEP85_RS03470 ENOG4105VEQ Cold shock protein HEP85_RS03500 ENOG4105CDH Citrulline--aspartate ligase HEP85_RS03525 ENOG4108JSS Haloalkane dehalogenase HEP85_RS03535 ENOG4108Z0Z intracellular protease Pfpi family HEP85_RS03540 ENOG4105CPC Aldo Keto reductase HEP85_RS03555 ENOG4105F52 Transcriptional regulator HEP85_RS03560 ENOG4105EQ0 Major Facilitator superfamily HEP85_RS03570 ENOG4105C26 Dehydrogenase HEP85_RS03620 ENOG4105DNP FAD linked oxidase domain protein HEP85_RS03640 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HEP85_RS03645 ENOG4105CG3 alpha amylase, catalytic region HEP85_RS03650 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HEP85_RS03685 ENOG4105E8G Major facilitator Superfamily HEP85_RS03710 ENOG4107VIJ nudix hydrolase HEP85_RS03725 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS03740 ENOG4105EGE secreted protein HEP85_RS03755 ENOG4105EX0 alpha-galactosidase HEP85_RS03775 ENOG4105E2R ROK family HEP85_RS03805 ENOG4108YYH Nadph-dependent fmn reductase HEP85_RS03840 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP85_RS03860 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HEP85_RS03880 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS03910 ENOG4105CIR epoxide hydrolase HEP85_RS03915 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP85_RS03920 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP85_RS03925 ENOG4105WBV Transcriptional regulator HEP85_RS03950 ENOG4105BZU Histidine kinase HEP85_RS04015 ENOG4105E7U AraC family transcriptional regulator HEP85_RS04025 ENOG4105CPC Aldo Keto reductase HEP85_RS04035 ENOG4108TM9 integral membrane protein HEP85_RS04045 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP85_RS04050 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HEP85_RS04055 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP85_RS04065 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HEP85_RS04070 ENOG4107S5I aldo keto reductase HEP85_RS04080 ENOG4105C26 Dehydrogenase HEP85_RS04090 ENOG4105CHP RNA polymerase HEP85_RS04095 ENOG4105GRZ Ycii-related protein HEP85_RS04105 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HEP85_RS04120 ENOG4105FBW Monooxygenase HEP85_RS04145 ENOG4105CGD Nad-dependent epimerase dehydratase HEP85_RS04150 ENOG4105CVP deoxyribo-dipyrimidine photolyase HEP85_RS04170 ENOG4105K6V RNA polymerase HEP85_RS04185 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEP85_RS04190 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEP85_RS04260 ENOG4105E4C Lytic transglycosylase catalytic HEP85_RS04280 ENOG4105DKQ ROK family HEP85_RS04315 ENOG4105C5X domain protein HEP85_RS04340 ENOG4105CAQ asparagine synthetase HEP85_RS04345 ENOG4105CBC glutamate synthase HEP85_RS04425 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HEP85_RS04435 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HEP85_RS04440 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HEP85_RS04485 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS04530 ENOG4105X7H acyl-CoA dehydrogenase HEP85_RS04560 ENOG4105D9U N-acetyltransferase HEP85_RS04575 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS04585 ENOG4105CMT Dihydroxyacetone kinase HEP85_RS04590 ENOG4108UTZ Dihydroxyacetone kinase HEP85_RS04605 ENOG4105CYP glycoside hydrolase, family HEP85_RS04620 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP85_RS04625 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP85_RS04640 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP85_RS04670 ENOG4105I82 acetyl xylan esterase HEP85_RS04695 ENOG4105EYF MMPL domain protein HEP85_RS04700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS04710 ENOG4105CIS alcohol dehydrogenase HEP85_RS04725 ENOG4105CG3 alpha amylase, catalytic region HEP85_RS04730 ENOG4105CHP RNA polymerase HEP85_RS04740 ENOG4105GRZ Ycii-related protein HEP85_RS04770 ENOG4105CSV Glutaminase HEP85_RS04775 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP85_RS04785 ENOG4105KJJ Uncharacterized ACR, COG1993 HEP85_RS04790 ENOG41083YR Protein CrcB homolog HEP85_RS04905 ENOG4105F1N DNA alkylation repair HEP85_RS04955 ENOG4105EMU Dehydrogenase HEP85_RS04965 ENOG4108JJA ABC, transporter HEP85_RS04985 ENOG4107RN3 metallophosphoesterase HEP85_RS05000 ENOG4108UW8 fha domain-containing protein HEP85_RS05050 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP85_RS05055 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HEP85_RS05060 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP85_RS05070 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP85_RS05095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP85_RS05105 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HEP85_RS05115 ENOG4105CMT Dihydroxyacetone kinase HEP85_RS05165 ENOG4108IUW ABC transporter HEP85_RS05185 ENOG4108JPW Aminotransferase HEP85_RS05200 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HEP85_RS05260 ENOG4105EW6 flavin reductase domain protein, FMN-binding HEP85_RS05285 ENOG4105CH2 amidohydrolase HEP85_RS05300 ENOG4108KYE ABC-2 type transporter HEP85_RS05430 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS05445 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP85_RS05495 ENOG4107RRZ synthase HEP85_RS05510 ENOG4105QVC MOSC domain-containing protein HEP85_RS05520 ENOG4106F1P AAA ATPase, central domain protein HEP85_RS05530 ENOG4105MVE transcriptional regulator HEP85_RS05560 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP85_RS05595 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HEP85_RS05600 ENOG4105D2N Aldolase HEP85_RS05605 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP85_RS05610 ENOG4105E98 transcriptional regulator DeoR family HEP85_RS05615 ENOG4105CWX Alpha-1,2-mannosidase HEP85_RS05620 ENOG4108IJ8 ABC transporter HEP85_RS05625 ENOG4105E90 ABC transporter HEP85_RS05645 ENOG4105GWZ Roadblock lc7 family protein HEP85_RS05660 ENOG4105C84 Histidine ammonia-lyase HEP85_RS05670 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP85_RS05680 ENOG4107P5I polyketide synthase HEP85_RS05735 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS05755 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HEP85_RS05760 ENOG4107PP3 Acetylornithine deacetylase HEP85_RS05765 ENOG4105I1F Resistance protein HEP85_RS05785 ENOG4105EX0 alpha-galactosidase HEP85_RS05795 ENOG41060NJ transcriptional regulator HEP85_RS05810 ENOG4105C10 Electron transfer flavoprotein HEP85_RS05835 ENOG4105PSQ Acyl-transferase HEP85_RS05865 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEP85_RS05935 ENOG4105C2W permease HEP85_RS05940 ENOG4105YVS arsR family transcriptional regulator HEP85_RS05945 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP85_RS05965 ENOG4105EMU Dehydrogenase HEP85_RS05985 ENOG4108KPJ rna polymerase sigma factor HEP85_RS05995 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP85_RS06010 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP85_RS06035 ENOG4105CRK lysyL-tRNA synthetase HEP85_RS06050 ENOG41082SX arsR family transcriptional regulator HEP85_RS06080 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HEP85_RS06090 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HEP85_RS06140 ENOG4107QRI Phosphoketolase HEP85_RS06145 ENOG4105CSR polyphosphate kinase 2 HEP85_RS06160 ENOG4107SHJ sulfite reductase subunit b HEP85_RS06180 ENOG4105C7W Xanthine dehydrogenase HEP85_RS06185 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HEP85_RS06225 ENOG4108RQS Two component transcriptional regulator (Winged helix family HEP85_RS06270 ENOG4107ZED Uncharacterised protein family UPF0047 HEP85_RS06275 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP85_RS06280 ENOG4105E2Y ABC, transporter HEP85_RS06290 ENOG4105FBW Monooxygenase HEP85_RS06295 ENOG4105H3G oxidoreductase HEP85_RS06305 ENOG4105BZ1 (ABC) transporter HEP85_RS06325 ENOG4105BZ1 (ABC) transporter HEP85_RS06330 ENOG4105BZ1 (ABC) transporter HEP85_RS06355 ENOG4105C29 acyl-CoA thioesterase HEP85_RS06365 ENOG4105GWZ Roadblock lc7 family protein HEP85_RS06385 ENOG4105GWZ Roadblock lc7 family protein HEP85_RS06395 ENOG4105BZU Histidine kinase HEP85_RS06455 ENOG4105C93 Xylose Isomerase HEP85_RS06460 ENOG4105CMG Carbohydrate kinase HEP85_RS06465 ENOG4105DKQ ROK family HEP85_RS06470 ENOG4105C85 amino acid HEP85_RS06475 ENOG4107SCA Formamidase (EC 3.5.1.49) HEP85_RS06480 ENOG4107RR1 TRANSCRIPTIONal HEP85_RS06485 ENOG4105C26 Dehydrogenase HEP85_RS06530 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HEP85_RS06550 ENOG4105EBR Carboxylesterase HEP85_RS06555 ENOG4108K8U Glycerol operon regulatory protein HEP85_RS06560 ENOG4105WZ4 isomerase HEP85_RS06580 ENOG4105BZU Histidine kinase HEP85_RS06585 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS06605 ENOG4108ZJ4 polysaccharide deacetylase HEP85_RS06615 ENOG4108RQS Two component transcriptional regulator (Winged helix family HEP85_RS06685 ENOG4105CBP Major Facilitator HEP85_RS06715 ENOG4105MC2 DSBA oxidoreductase HEP85_RS06770 ENOG41086KC Transcriptional regulator HEP85_RS06790 ENOG4105D2B acyl-CoA dehydrogenase HEP85_RS06795 ENOG4105D2B acyl-CoA dehydrogenase HEP85_RS06800 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEP85_RS06815 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HEP85_RS06840 ENOG41065KQ synthase HEP85_RS06845 ENOG4106A3M Cytochrome p-450 HEP85_RS06855 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS06865 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP85_RS06875 ENOG4105F1K Glutamine amidotransferase HEP85_RS06880 ENOG4105CTQ phosphohexokinase HEP85_RS06895 ENOG4108HRK Histidine kinase HEP85_RS06910 ENOG4108NEV two component transcriptional regulator, LytTR family HEP85_RS06920 ENOG4105CIK Amidinotransferase HEP85_RS06925 ENOG4105C8Y Acetylornithine aminotransferase HEP85_RS06930 ENOG4105F6E Acyl-transferase HEP85_RS06945 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HEP85_RS06955 ENOG4105CQM Urea amidohydrolase subunit alpha HEP85_RS06960 ENOG4105KI2 Urea amidohydrolase subunit beta HEP85_RS06965 ENOG4108YZ9 Urea amidohydrolase subunit gamma HEP85_RS06995 ENOG4105DDW LysR family Transcriptional regulator HEP85_RS07020 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HEP85_RS07025 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP85_RS07030 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HEP85_RS07035 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS07055 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP85_RS07065 ENOG4108R6G acetyltransferase HEP85_RS07085 ENOG4105C83 adenylosuccinate lyase HEP85_RS07090 ENOG4108VCA G U mismatch-specific DNA glycosylase HEP85_RS07105 ENOG4105BZU Histidine kinase HEP85_RS07110 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS07115 ENOG4105DKQ ROK family HEP85_RS07120 ENOG4105FDP GntR family transcriptional regulator HEP85_RS07125 ENOG4108KPJ rna polymerase sigma factor HEP85_RS07130 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HEP85_RS07190 ENOG4107RH8 nuclease SbcCD subunit D HEP85_RS07195 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HEP85_RS07225 ENOG4105K4P CoA-binding domain protein HEP85_RS07255 ENOG4108UW5 maltose o-acetyltransferase HEP85_RS07260 ENOG4108Z0R Transferase HEP85_RS07270 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HEP85_RS07295 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEP85_RS07305 ENOG4105CHU acetyl-coa acetyltransferase HEP85_RS07330 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HEP85_RS07350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP85_RS07360 ENOG4105DEN Luciferase family HEP85_RS07370 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HEP85_RS07375 ENOG4105EP9 oxidoreductase HEP85_RS07390 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HEP85_RS07395 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HEP85_RS07405 ENOG4106YT9 Enoyl-CoA hydratase HEP85_RS07410 ENOG4105CHR reductase HEP85_RS07455 ENOG4108YIQ Alpha beta hydrolase HEP85_RS07480 ENOG4108Q5Y Membrane HEP85_RS07510 ENOG4105NTW Transcriptional regulator HEP85_RS07515 ENOG4107TIF Phenazine biosynthesis protein, PhzF family HEP85_RS07545 ENOG4105DR5 peptidase HEP85_RS07550 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HEP85_RS07560 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEP85_RS07580 ENOG4108UW8 fha domain-containing protein HEP85_RS07630 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HEP85_RS07640 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP85_RS07660 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP85_RS07665 ENOG4105BZU Histidine kinase HEP85_RS07670 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP85_RS07675 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP85_RS07695 ENOG4105GWZ Roadblock lc7 family protein HEP85_RS07715 ENOG4105VQD rieske 2fe-2S domain-containing protein HEP85_RS07720 ENOG41069M3 Transcriptional regulator HEP85_RS07735 ENOG4105F76 Sarcosine oxidase HEP85_RS07740 ENOG4105DVW rieske (2Fe-2S) HEP85_RS07790 ENOG4105E7W lamb ycsf family protein HEP85_RS07810 ENOG4108MJN Glycosyl Transferase HEP85_RS07825 ENOG4105JXB ankyrin repeat-containing protein HEP85_RS07855 ENOG4105DEU major facilitator superfamily HEP85_RS07860 ENOG4105Q70 HEP85_RS07870 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HEP85_RS07880 ENOG4105EW9 transcriptional regulator AsnC family HEP85_RS07900 ENOG4107Z3H Transcriptional regulator, TetR family HEP85_RS07945 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HEP85_RS07950 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HEP85_RS07955 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HEP85_RS07980 ENOG4106UW1 Major Facilitator superfamily HEP85_RS07995 ENOG4105C2W permease HEP85_RS08055 ENOG4105CUB amino acid HEP85_RS08075 ENOG4105DKT Transcriptional regulator HEP85_RS08080 ENOG4105DJV ribulose-phosphate 3-epimerase HEP85_RS08105 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HEP85_RS08120 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HEP85_RS08130 ENOG4105SKN orotidine 5''-phosphate decarboxylase HEP85_RS08135 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HEP85_RS08140 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HEP85_RS08145 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HEP85_RS08155 ENOG4105CD3 dihydroorotase HEP85_RS08160 ENOG4105CXT aspartate transcarbamylase HEP85_RS08165 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HEP85_RS08175 ENOG410803B Involved in the transcription termination process (By similarity) HEP85_RS08180 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HEP85_RS08185 ENOG4105DC7 peptidase M24 HEP85_RS08195 ENOG4105D49 3-dehydroquinate synthase HEP85_RS08200 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HEP85_RS08205 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HEP85_RS08215 ENOG4105HHA aminodeoxychorismate lyase HEP85_RS08220 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HEP85_RS08225 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HEP85_RS08245 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HEP85_RS08265 ENOG4105CUT histidyl-tRNA synthetase HEP85_RS08275 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HEP85_RS08280 ENOG4105C99 atpase involved in dna repair HEP85_RS08285 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEP85_RS08290 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HEP85_RS08295 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEP85_RS08300 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEP85_RS08310 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEP85_RS08315 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HEP85_RS08320 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HEP85_RS08325 ENOG4105CDY transcriptional regulatory protein HEP85_RS08330 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HEP85_RS08335 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HEP85_RS08345 ENOG4105E2K Glycosyl transferase (Group 1 HEP85_RS08350 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HEP85_RS08375 ENOG4105EYW Ion transport protein HEP85_RS08380 ENOG4105C22 threonyL-tRNA synthetase HEP85_RS08395 ENOG4108JDX DNA polymerase iii, epsilon subunit HEP85_RS08420 ENOG4105KF0 sporulation and cell division protein, SsgA HEP85_RS08450 ENOG4105F0I Aminotransferase HEP85_RS08455 ENOG4105CRQ synthase (Component I) HEP85_RS08515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HEP85_RS08535 ENOG4105D01 (LipO)protein HEP85_RS08540 ENOG4108UMI ABC transporter, permease HEP85_RS08545 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEP85_RS08580 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS08585 ENOG4105C57 major facilitator superfamily HEP85_RS08590 ENOG4105RJZ Transcriptional regulator HEP85_RS08600 ENOG4105CH7 arginosuccinase HEP85_RS08605 ENOG4105CDH Citrulline--aspartate ligase HEP85_RS08635 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HEP85_RS08640 ENOG4105C8Y Acetylornithine aminotransferase HEP85_RS08645 ENOG4105CAS nag kinase HEP85_RS08650 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HEP85_RS08655 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HEP85_RS08695 ENOG4105T38 integral membrane protein HEP85_RS08705 ENOG4105F32 YngK protein HEP85_RS08745 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HEP85_RS08750 ENOG4105BZU Histidine kinase HEP85_RS08755 ENOG4108RWN rrna methyltransferase HEP85_RS08760 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HEP85_RS08765 ENOG41084BS 50S ribosomal protein L35 HEP85_RS08770 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HEP85_RS08830 ENOG4105C26 Dehydrogenase HEP85_RS08835 ENOG4105C5F glutamine synthetase HEP85_RS08865 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HEP85_RS08875 ENOG4108HQS Glycine betaine HEP85_RS08880 ENOG4108IJ7 Glycine betaine HEP85_RS08885 ENOG4105HFS 5'-3' exonuclease HEP85_RS08895 ENOG4105D3G Pseudouridine synthase HEP85_RS08925 ENOG4105MKU Transcriptional regulator HEP85_RS08960 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEP85_RS08965 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEP85_RS08995 ENOG4108V1T peptidylprolyl cis-trans isomerase HEP85_RS09000 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HEP85_RS09010 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS09015 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HEP85_RS09020 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HEP85_RS09030 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HEP85_RS09035 ENOG4105E5F proteasome HEP85_RS09040 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HEP85_RS09075 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS09080 ENOG4108J59 Extracellular solute-binding protein, family 5 HEP85_RS09090 ENOG4107URF beta-phospho-glucomutase HEP85_RS09095 ENOG4105C3R Methionine synthase HEP85_RS09100 ENOG4108K8U Glycerol operon regulatory protein HEP85_RS09105 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP85_RS09110 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP85_RS09115 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEP85_RS09120 ENOG4105JXH GntR family transcriptional regulator HEP85_RS09140 ENOG4105C8N cysteinyl-tRNA synthetase HEP85_RS09160 ENOG4105D7N magnesium and cobalt transport protein CorA HEP85_RS09170 ENOG4105DYW oxidoreductase HEP85_RS09175 ENOG4105CPC Aldo Keto reductase HEP85_RS09205 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEP85_RS09220 ENOG4105CD8 aminopeptidase N HEP85_RS09225 ENOG4105K5B UPF0225 protein HEP85_RS09230 ENOG4105C6F GntR Family Transcriptional Regulator HEP85_RS09235 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEP85_RS09240 ENOG4105C6Z Gluconate HEP85_RS09245 ENOG4105CHR reductase HEP85_RS09275 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein HEP85_RS09285 ENOG4105PTV Nudix Hydrolase HEP85_RS09290 ENOG4105VG5 Membrane HEP85_RS09315 ENOG4108IG5 Transcriptional regulator HEP85_RS09320 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS09330 ENOG4105EHZ conserved protein UCP016719 HEP85_RS09355 ENOG4108Z4X TRANSCRIPTIONal HEP85_RS09375 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS09385 ENOG4108ZHR arsR family transcriptional regulator HEP85_RS09420 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP85_RS09425 ENOG4108SGK Tetr family transcriptional regulator HEP85_RS09435 ENOG4105F1J Homogentisate 1,2-dioxygenase HEP85_RS09455 ENOG4105RNG membrane HEP85_RS09460 ENOG4105K6V RNA polymerase HEP85_RS09485 ENOG4105D9P serine threonine protein kinase HEP85_RS09490 ENOG4108TCJ secreted hydrolase HEP85_RS09505 ENOG4106WTF Glycosyl transferase, family 2 HEP85_RS09510 ENOG4105K64 Glycosyl transferase, family 2 HEP85_RS09515 ENOG4107BJW polysaccharide deacetylase HEP85_RS09535 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HEP85_RS09570 ENOG4108Z2K Cupin 2, conserved barrel domain protein HEP85_RS09580 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP85_RS09590 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEP85_RS09610 ENOG4106NMR serine protease HEP85_RS09645 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HEP85_RS09655 ENOG4105C57 major facilitator superfamily HEP85_RS09665 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP85_RS09700 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HEP85_RS09710 ENOG4105CAT Cytidine monophosphate kinase HEP85_RS09750 ENOG410756H nucleotidyltransferase HEP85_RS09755 ENOG41065RQ ADP-ribosylation crystallin J1 HEP85_RS09770 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HEP85_RS09790 ENOG4105DCF alanine dehydrogenase HEP85_RS09800 ENOG4108YZ4 nudix hydrolase HEP85_RS09805 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HEP85_RS09810 ENOG4105BZP glycoside hydrolase 15-related HEP85_RS09835 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HEP85_RS09855 ENOG4105E0A ABC, transporter HEP85_RS09860 ENOG4105TVJ transport system, permease HEP85_RS09865 ENOG4105DQ5 transport system permease protein HEP85_RS09905 ENOG4108VX5 3-methyladenine DNA glycosylase HEP85_RS09915 ENOG4108V1U phospholipid-binding protein HEP85_RS09935 ENOG4105DKW ABC transporter HEP85_RS09955 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS09960 ENOG4105ENE Histidine kinase HEP85_RS09970 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HEP85_RS09980 ENOG4105IDI abc transporter atp-binding protein HEP85_RS09990 ENOG4105EAC phosphoserine phosphatase HEP85_RS10010 ENOG4107YCY Transcriptional regulator HEP85_RS10025 ENOG4105CHR reductase HEP85_RS10040 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HEP85_RS10060 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP85_RS10065 ENOG4107QN1 sodium solute HEP85_RS10090 ENOG4105E2A Dehydrogenase HEP85_RS10135 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP85_RS10150 ENOG4105BZP glycoside hydrolase 15-related HEP85_RS10155 ENOG4105CHR reductase HEP85_RS10185 ENOG4105VBF alkaline shock protein HEP85_RS10195 ENOG4106YT9 Enoyl-CoA hydratase HEP85_RS10205 ENOG4105C5H ABC transporter HEP85_RS10235 ENOG4107W7X Aldolase HEP85_RS10255 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HEP85_RS10260 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEP85_RS10265 ENOG4105CTK cobaltochelatase, cobn subunit HEP85_RS10275 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HEP85_RS10280 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEP85_RS10295 ENOG4105CIA precorrin-4 C(11)-methyltransferase HEP85_RS10305 ENOG4105E4R Precorrin-3B C17-methyltransferase HEP85_RS10310 ENOG41081F0 Precorrin-8x methylmutase HEP85_RS10315 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HEP85_RS10340 ENOG4105DRP amino acid AbC transporter HEP85_RS10345 ENOG4105CT1 (ABC) transporter HEP85_RS10365 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HEP85_RS10370 ENOG4108JPW Aminotransferase HEP85_RS10375 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HEP85_RS10380 ENOG4105EV8 ectoine hydroxylase HEP85_RS10410 ENOG4107HP6 Transcriptional regulator HEP85_RS10420 ENOG4105CJN penicillin-binding protein HEP85_RS10425 ENOG4105C7N Xanthine uracil vitamin C permease HEP85_RS10465 ENOG4107T3P ABC, transporter HEP85_RS10470 ENOG4105E4I Glycoside hydrolase family 28 HEP85_RS10500 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP85_RS10505 ENOG4105DRR Transcriptional regulator, GntR family HEP85_RS10530 ENOG4105E9Z Nad-dependent epimerase dehydratase HEP85_RS10535 ENOG4105E98 transcriptional regulator DeoR family HEP85_RS10555 ENOG4105CPQ Dehydrogenase HEP85_RS10565 ENOG4105XEA Tetr family transcriptional regulator HEP85_RS10620 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP85_RS10630 ENOG4105NAF rna polymerase sigma factor HEP85_RS10660 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HEP85_RS10665 ENOG4108RFG Tetr family transcriptional regulator HEP85_RS10670 ENOG410814C multidrug resistance protein HEP85_RS10685 ENOG4108UNV SUF system FeS assembly protein, NifU family HEP85_RS10690 ENOG4105C9B Cysteine desulfurase HEP85_RS10695 ENOG4105C3K feS assembly ATPase SufC HEP85_RS10705 ENOG4105JRK feS assembly protein SufD HEP85_RS10720 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HEP85_RS10725 ENOG4105CJ1 ABC, transporter HEP85_RS10735 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HEP85_RS10755 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HEP85_RS10765 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEP85_RS10785 ENOG4107QP8 phosphohexose isomerase HEP85_RS10805 ENOG4105CP7 Triose-phosphate isomerase HEP85_RS10810 ENOG4105BZA Phosphoglycerate kinase HEP85_RS10815 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEP85_RS10825 ENOG4105CIE May be required for sporulation (By similarity) HEP85_RS10830 ENOG4105CHW UPF0052 protein HEP85_RS10835 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HEP85_RS10840 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HEP85_RS10865 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEP85_RS10875 ENOG4107VMB Beta-lactamase domain protein HEP85_RS10880 ENOG4107R0W ABC transporter HEP85_RS10885 ENOG4105E5Q amino acid AbC transporter HEP85_RS10895 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HEP85_RS10900 ENOG4105CSH Transporter HEP85_RS10925 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HEP85_RS10930 ENOG4105BZU Histidine kinase HEP85_RS10935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEP85_RS10940 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEP85_RS10955 ENOG4105E2A Dehydrogenase HEP85_RS10965 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HEP85_RS10975 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS10980 ENOG4105D7N magnesium and cobalt transport protein CorA HEP85_RS11075 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HEP85_RS11135 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HEP85_RS11160 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS11205 ENOG4105KA0 thioesterase Superfamily protein HEP85_RS11215 ENOG4105C32 Amino acid ABC transporter (Permease) HEP85_RS11220 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HEP85_RS11225 ENOG4105C0Z ABC transporter HEP85_RS11230 ENOG4108IV0 ABC, transporter HEP85_RS11260 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HEP85_RS11280 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HEP85_RS11310 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HEP85_RS11320 ENOG41060WC Enoyl-CoA hydratase HEP85_RS11335 ENOG4105EA8 2-Nitropropane dioxygenase HEP85_RS11340 ENOG4105F2C Acetyl-CoA acetyltransferase HEP85_RS11345 ENOG4108RZE Tetr family transcriptional regulator HEP85_RS11355 ENOG4105D2B acyl-CoA dehydrogenase HEP85_RS11390 ENOG4105CBC glutamate synthase HEP85_RS11425 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP85_RS11430 ENOG4105CI0 Citrate lyase HEP85_RS11445 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HEP85_RS11450 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HEP85_RS11460 ENOG4105DK0 Indole-3-glycerol phosphate synthase HEP85_RS11485 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HEP85_RS11495 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HEP85_RS11500 ENOG4108176 endoribonuclease L-psp HEP85_RS11505 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HEP85_RS11510 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HEP85_RS11520 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HEP85_RS11525 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP85_RS11530 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HEP85_RS11550 ENOG4108Z66 YbaK ebsC protein HEP85_RS11580 ENOG4105C0B DNA polymerase III (alpha subunit) HEP85_RS11630 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HEP85_RS11645 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HEP85_RS11650 ENOG4107VQS DivIVA family HEP85_RS11660 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HEP85_RS11665 ENOG4105DFA alanine racemase domain protein HEP85_RS11670 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HEP85_RS11675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HEP85_RS11685 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HEP85_RS11695 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HEP85_RS11700 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HEP85_RS11710 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HEP85_RS11715 ENOG4105CJN penicillin-binding protein HEP85_RS11725 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HEP85_RS11735 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HEP85_RS11755 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEP85_RS11765 ENOG4105IDI abc transporter atp-binding protein HEP85_RS11775 ENOG4107Z3H Transcriptional regulator, TetR family HEP85_RS11785 ENOG4105EWK phytoene HEP85_RS11825 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HEP85_RS11835 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HEP85_RS11845 ENOG4108UQY Iron-storage protein HEP85_RS11855 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HEP85_RS11870 ENOG4105CTQ phosphohexokinase HEP85_RS11905 ENOG4105DKQ ROK family HEP85_RS11990 ENOG4108I0Q anthranilate phosphoribosyltransferase HEP85_RS11995 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP85_RS12000 ENOG4107EUI c reductase, iron-sulfur HEP85_RS12005 ENOG4107UDY cytochrome C HEP85_RS12010 ENOG4105CCU oxidase (Subunit III) HEP85_RS12020 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HEP85_RS12025 ENOG4105MCD Part of cytochrome c oxidase, its function is HEP85_RS12030 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP85_RS12035 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HEP85_RS12045 ENOG4107T4Z adenosine kinase HEP85_RS12065 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HEP85_RS12075 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS12100 ENOG4105DXX methyltransferase HEP85_RS12120 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HEP85_RS12125 ENOG4105CRK lysyL-tRNA synthetase HEP85_RS12140 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HEP85_RS12145 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HEP85_RS12165 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEP85_RS12185 ENOG4105C0H protease HEP85_RS12190 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) HEP85_RS12210 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEP85_RS12215 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HEP85_RS12235 ENOG4105C5F glutamine synthetase HEP85_RS12240 ENOG4105D0M Protease HtpX homolog HEP85_RS12270 ENOG4108222 arsenate reductase HEP85_RS12275 ENOG4106SPC secreted protein HEP85_RS12285 ENOG4107R5B glutamine synthetase HEP85_RS12290 ENOG4107NHD transcriptional regulator HEP85_RS12330 ENOG41060BG Tetr family transcriptional regulator HEP85_RS12355 ENOG4105CG3 alpha amylase, catalytic region HEP85_RS12360 ENOG4105EG2 ABC transporter, permease HEP85_RS12365 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HEP85_RS12375 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS12385 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HEP85_RS12395 ENOG4105FBN Acid phosphatase HEP85_RS12420 ENOG4105C57 major facilitator superfamily HEP85_RS12445 ENOG4105D74 hydrolase HEP85_RS12455 ENOG4105C5F glutamine synthetase HEP85_RS12460 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP85_RS12465 ENOG41081JD Transcriptional regulator HEP85_RS12490 ENOG4105F27 Major Facilitator HEP85_RS12505 ENOG4105C57 major facilitator superfamily HEP85_RS12510 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HEP85_RS12530 ENOG4107XZ0 Peptidase M50 HEP85_RS12545 ENOG4108478 ec 3.2.1.18 HEP85_RS12585 ENOG410650H (LipO)protein HEP85_RS12600 ENOG4106A0S HEP85_RS12605 ENOG4105C8T Leucyl-tRNA synthetase HEP85_RS12615 ENOG4105CIK Amidinotransferase HEP85_RS12625 ENOG4107S1E Beta-lactamase HEP85_RS12630 ENOG4105C2C drug resistance transporter, Bcr CflA HEP85_RS12655 ENOG4105C19 ABC transporter HEP85_RS12675 ENOG4105GCF PGAM HEP85_RS12690 ENOG4105CHR reductase HEP85_RS12695 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP85_RS12725 ENOG4105E4C Lytic transglycosylase catalytic HEP85_RS12755 ENOG4105E7U AraC family transcriptional regulator HEP85_RS12770 ENOG4108UHU Aldolase HEP85_RS12785 ENOG4105EGD dinuclear metal center protein, YbgI family HEP85_RS12795 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HEP85_RS12810 ENOG4108M15 ABC transporter HEP85_RS12820 ENOG4105BZU Histidine kinase HEP85_RS12840 ENOG4105CHU acetyl-coa acetyltransferase HEP85_RS12865 ENOG4105DYW oxidoreductase HEP85_RS12885 ENOG4107QVI Methyltransferase, type 11 HEP85_RS12895 ENOG4108SGK Tetr family transcriptional regulator HEP85_RS12950 ENOG4105XPP Protein of unknown function (DUF1275) HEP85_RS12960 ENOG4105F2C Acetyl-CoA acetyltransferase HEP85_RS12965 ENOG4106A3M Cytochrome p-450 HEP85_RS12975 ENOG4105CSH Transporter HEP85_RS13060 ENOG4105E8R UPF0173 metal-dependent hydrolase HEP85_RS13070 ENOG4105D3W isochorismatase HEP85_RS13125 ENOG4106A3M Cytochrome p-450 HEP85_RS13215 ENOG4105UA4 acetyltransferase HEP85_RS13265 ENOG4105BZ4 penicillin-binding protein HEP85_RS13325 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEP85_RS13330 ENOG4105EYW Ion transport protein HEP85_RS13355 ENOG4105CPC Aldo Keto reductase HEP85_RS13360 ENOG4105VUF Transcriptional regulator HEP85_RS13390 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP85_RS13395 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEP85_RS13415 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEP85_RS13420 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP85_RS13425 ENOG4108R86 Transcriptional regulator HEP85_RS13440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP85_RS13450 ENOG4105NGS secreted protein HEP85_RS13470 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP85_RS13475 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEP85_RS13505 ENOG4105DFW ABC transporter HEP85_RS13520 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEP85_RS13560 ENOG4105J4Q Transcriptional regulator HEP85_RS13585 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS13595 ENOG4105DFF Rod shape-determining protein mreb HEP85_RS13645 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS13650 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HEP85_RS13660 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HEP85_RS13670 ENOG4107GZ4 SanA protein HEP85_RS13715 ENOG4108IND Tetr family transcriptional regulator HEP85_RS13720 ENOG4105CHR reductase HEP85_RS13725 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP85_RS13730 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEP85_RS13735 ENOG4105E2R ROK family HEP85_RS13795 ENOG4105CPC Aldo Keto reductase HEP85_RS13805 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HEP85_RS13810 ENOG4105DSE periplasmic solute binding protein HEP85_RS13815 ENOG4105FDK ABC transporter HEP85_RS13835 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HEP85_RS13855 ENOG4105JXH GntR family transcriptional regulator HEP85_RS13860 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP85_RS13870 ENOG4105C3U ABC transporter HEP85_RS13885 ENOG4108478 ec 3.2.1.18 HEP85_RS13895 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP85_RS13905 ENOG4105D4Y metalloprotease HEP85_RS13950 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HEP85_RS13960 ENOG4105MSB protein, conserved in bacteria HEP85_RS13970 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HEP85_RS13995 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HEP85_RS14000 ENOG4107YU2 histidine triad (hIT) protein HEP85_RS14020 ENOG4107QWG 2-Nitropropane dioxygenase HEP85_RS14025 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HEP85_RS14030 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HEP85_RS14070 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HEP85_RS14080 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HEP85_RS14085 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HEP85_RS14105 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HEP85_RS14115 ENOG4105KQC Competence protein HEP85_RS14120 ENOG4105EPR degv family HEP85_RS14130 ENOG4105C8T Leucyl-tRNA synthetase HEP85_RS14140 ENOG4107QIZ NADH dehydrogenase HEP85_RS14175 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP85_RS14190 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HEP85_RS14220 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HEP85_RS14260 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HEP85_RS14265 ENOG4105K46 50S ribosomal protein l27 HEP85_RS14270 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HEP85_RS14275 ENOG4105J5G Transferase hexapeptide repeat containing protein HEP85_RS14285 ENOG4108IJ1 Dehydrogenase HEP85_RS14300 ENOG4105EP9 oxidoreductase HEP85_RS14305 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HEP85_RS14335 ENOG41082YX Transcriptional regulator, arsr family HEP85_RS14340 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP85_RS14370 ENOG4105CIR epoxide hydrolase HEP85_RS14410 ENOG4105CNI cell division protein FtsW HEP85_RS14415 ENOG4105CJN penicillin-binding protein HEP85_RS14430 ENOG4105DFF Rod shape-determining protein mreb HEP85_RS14435 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HEP85_RS14445 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HEP85_RS14450 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HEP85_RS14460 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HEP85_RS14465 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HEP85_RS14475 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HEP85_RS14500 ENOG4108TGC Acyltransferase HEP85_RS14530 ENOG4105C85 amino acid HEP85_RS14535 ENOG4107TPY serine threonine protein kinase HEP85_RS14550 ENOG4105C85 amino acid HEP85_RS14555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEP85_RS14560 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP85_RS14570 ENOG4105MC2 DSBA oxidoreductase HEP85_RS14600 ENOG4108UYE Lactoylglutathione lyase HEP85_RS14610 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP85_RS14700 ENOG4105CIG ABC transporter HEP85_RS14720 ENOG4105D8X mechanosensitive ion channel HEP85_RS14760 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HEP85_RS14770 ENOG4105F8D glycoside hydrolase family 4 HEP85_RS14785 ENOG4105CT1 (ABC) transporter HEP85_RS14815 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HEP85_RS14820 ENOG4108Z18 K06886 hemoglobin HEP85_RS14840 ENOG4105D3W isochorismatase HEP85_RS14860 ENOG4105DU0 nucleoside hydrolase HEP85_RS14980 ENOG4105VHU single-stranded DNA-binding protein HEP85_RS15010 ENOG4108JQ1 Dehydrogenase HEP85_RS15080 ENOG4105D3Q Sugar transferase HEP85_RS15090 ENOG4105CJR Integral membrane protein (MviN HEP85_RS15120 ENOG4105S2J secreted protein HEP85_RS15180 ENOG4105C26 Dehydrogenase HEP85_RS15185 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEP85_RS15190 ENOG4105DH8 myo-inositol catabolism HEP85_RS15200 ENOG4105EDK PfkB domain protein HEP85_RS15205 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HEP85_RS15245 ENOG4105C7H Helicase, RecD TraA family HEP85_RS15255 ENOG4105C2J ABC transporter HEP85_RS15260 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP85_RS15265 ENOG4108RVA ribokinase HEP85_RS15270 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HEP85_RS15295 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS15300 ENOG4105HSS phospholipase C HEP85_RS15305 ENOG410645S MarR family Transcriptional regulator HEP85_RS15315 ENOG4105E8G Major facilitator Superfamily HEP85_RS15320 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HEP85_RS15325 ENOG4108594 Permease of the drug metabolite transporter HEP85_RS15335 ENOG4105D17 glycoside hydrolase, family 3 domain protein HEP85_RS15370 ENOG4108K8S endonuclease I HEP85_RS15375 ENOG4105C7K acetolactate synthase HEP85_RS15385 ENOG4105CK7 Sodium proline symporter HEP85_RS15395 ENOG4108XFF HEP85_RS15405 ENOG4105C29 acyl-CoA thioesterase HEP85_RS15420 ENOG4107QX3 carboxylase HEP85_RS15430 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HEP85_RS15435 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS15455 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HEP85_RS15465 ENOG4105DUU IucA IucC family protein HEP85_RS15470 ENOG4105E2D ec 3.2.1.52 HEP85_RS15490 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP85_RS15515 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HEP85_RS15530 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS15555 ENOG4108NNZ chitinase HEP85_RS15560 ENOG4105GR3 Histidine kinase HEP85_RS15590 ENOG4105CVJ phosphoglycerate mutase HEP85_RS15640 ENOG4105BZU Histidine kinase HEP85_RS15645 ENOG4105DEN Luciferase family HEP85_RS15660 ENOG4105C5I Dehydrogenase HEP85_RS15665 ENOG4105DV0 amidase (EC 3.5.1.4 HEP85_RS15705 ENOG4105DFM M18 family aminopeptidase HEP85_RS15710 ENOG4105J5T Amp-dependent synthetase and ligase HEP85_RS15720 ENOG4108M1A Chitin-binding protein HEP85_RS15750 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HEP85_RS15795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP85_RS15805 ENOG4105MWK D-amino acid dehydrogenase, small subunit HEP85_RS15810 ENOG4105FDP GntR family transcriptional regulator HEP85_RS15825 ENOG4105D9R oxidoreductase HEP85_RS15830 ENOG41090KN UPF0303 protein HEP85_RS15840 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HEP85_RS15850 ENOG4108U4N (sortase) family HEP85_RS15965 ENOG4105D2S major facilitator superfamily HEP85_RS15970 ENOG4106BRA Membrane HEP85_RS16000 ENOG4105BZ4 penicillin-binding protein HEP85_RS16040 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HEP85_RS16050 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HEP85_RS16070 ENOG4108RQ5 Beta-lactamase domain-containing protein HEP85_RS16095 ENOG4105C85 amino acid HEP85_RS16105 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HEP85_RS16115 ENOG4108RWI nicotinamidase HEP85_RS16145 ENOG4105KF0 sporulation and cell division protein, SsgA HEP85_RS16150 ENOG4105CQB FAD linked oxidase domain protein HEP85_RS16160 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HEP85_RS16170 ENOG4105E90 ABC transporter HEP85_RS16175 ENOG4108IJ8 ABC transporter HEP85_RS16180 ENOG4105E90 ABC transporter HEP85_RS16200 ENOG41063PX domain protein HEP85_RS16215 ENOG41086VY Fic/DOC family HEP85_RS16265 ENOG4105E2D ec 3.2.1.52 HEP85_RS16290 ENOG4108UJU UPF0301 protein HEP85_RS16295 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HEP85_RS16300 ENOG4108426 dNA-binding protein HEP85_RS16310 ENOG4105EEM helicase HEP85_RS16340 ENOG4105DQQ Major facilitator superfamily MFS_1 HEP85_RS16365 ENOG4105CN8 Transcriptional regulator HEP85_RS16390 ENOG4105CJQ hydrolase, family 31 HEP85_RS16395 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS16415 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HEP85_RS16420 ENOG4105CN1 protease HEP85_RS16430 ENOG4105CAK Cell division ATP-binding protein ftsE HEP85_RS16445 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HEP85_RS16455 ENOG4108UGD Serine Threonine protein kinase HEP85_RS16475 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HEP85_RS16480 ENOG4107SJB teichoic acid biosynthesis HEP85_RS16485 ENOG4107SJB teichoic acid biosynthesis HEP85_RS16500 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP85_RS16505 ENOG4105K56 Transcriptional regulator HEP85_RS16545 ENOG4108JGH Tetr family transcriptional regulator HEP85_RS16555 ENOG4105EY8 ABC transporter HEP85_RS16560 ENOG4105CG5 Glycosyl transferase (Group 1 HEP85_RS16575 ENOG4105C7I Dehydrogenase HEP85_RS16600 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP85_RS16610 ENOG4105T0Z Conserved Protein HEP85_RS16615 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS16620 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HEP85_RS16630 ENOG4105G3P Lipoprotein lpqB HEP85_RS16640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS16645 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HEP85_RS16665 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HEP85_RS16705 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HEP85_RS16715 ENOG4105EIP mannose-6-phosphate isomerase HEP85_RS16725 ENOG4105W49 UPF0434 protein HEP85_RS16730 ENOG4107QKV phosphomannomutase HEP85_RS16735 ENOG4105DAA L-lactate HEP85_RS16760 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP85_RS16775 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HEP85_RS16785 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HEP85_RS16800 ENOG4108KGH TRANSCRIPTIONal HEP85_RS16805 ENOG4107TB5 TRANSCRIPTIONal HEP85_RS16820 ENOG4108KGH TRANSCRIPTIONal HEP85_RS16830 ENOG4105PAD Hydrolase HEP85_RS16850 ENOG4105C6Y Udp-glucose 6-dehydrogenase HEP85_RS16905 ENOG41065SU Two-component system sensor kinase HEP85_RS16910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS16915 ENOG4105DUX Transporter HEP85_RS16945 ENOG41082AN stage II sporulation protein HEP85_RS16950 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS16960 ENOG4105CI2 imidazolone-5-propionate hydrolase HEP85_RS16975 ENOG4105CGP Urocanate hydratase HEP85_RS17015 ENOG4105C84 Histidine ammonia-lyase HEP85_RS17020 ENOG4108IJ8 ABC transporter HEP85_RS17025 ENOG4105E90 ABC transporter HEP85_RS17030 ENOG4105E90 ABC transporter HEP85_RS17040 ENOG41060NJ transcriptional regulator HEP85_RS17070 ENOG4105CHU acetyl-coa acetyltransferase HEP85_RS17105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP85_RS17110 ENOG4107RBB ABC transporter, permease HEP85_RS17115 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEP85_RS17140 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HEP85_RS17155 ENOG4106A3M Cytochrome p-450 HEP85_RS17230 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP85_RS17235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP85_RS17240 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP85_RS17250 ENOG4107QN1 sodium solute HEP85_RS17280 ENOG4105BZU Histidine kinase HEP85_RS17295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEP85_RS17300 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HEP85_RS17305 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HEP85_RS17315 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HEP85_RS17325 ENOG41067SE Tetr family transcriptional regulator HEP85_RS17345 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HEP85_RS17350 ENOG4108ZT1 Transcriptional regulator HEP85_RS17365 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HEP85_RS17410 ENOG4105C5H ABC transporter HEP85_RS17425 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HEP85_RS17435 ENOG4105F8V Hydrolase, tatD family HEP85_RS17475 ENOG4105GFG DUF218 domain HEP85_RS17600 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP85_RS17605 ENOG4108JJB ABC transporter HEP85_RS17615 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEP85_RS17645 ENOG4108R85 Short chain dehydrogenase HEP85_RS17650 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HEP85_RS17655 ENOG4105F95 Monooxygenase HEP85_RS17665 ENOG4105CGK Exodeoxyribonuclease III HEP85_RS17685 ENOG4105D9U N-acetyltransferase HEP85_RS17690 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP85_RS17695 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEP85_RS17705 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEP85_RS17710 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HEP85_RS17725 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP85_RS17735 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HEP85_RS17745 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HEP85_RS17780 ENOG4105DM4 PTS System HEP85_RS17785 ENOG4105DE4 1-phosphofructokinase HEP85_RS17790 ENOG410804X Transcriptional regulator HEP85_RS17810 ENOG4108Z7F N-acetyltransferase HEP85_RS17850 ENOG4105C57 major facilitator superfamily HEP85_RS17890 ENOG4105FDP GntR family transcriptional regulator HEP85_RS17905 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS17960 ENOG4108V06 Glutathione peroxidase HEP85_RS17975 ENOG4105DZ1 carboxypeptidase HEP85_RS18030 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP85_RS18045 ENOG4105EMU Dehydrogenase HEP85_RS18050 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HEP85_RS18090 ENOG4105F0K SARP family transcriptional regulator HEP85_RS18100 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS18135 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HEP85_RS18170 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEP85_RS18195 ENOG4105H3G oxidoreductase HEP85_RS18205 ENOG4105CGU Enoyl-CoA hydratase HEP85_RS18220 ENOG4105D2S major facilitator superfamily HEP85_RS18235 ENOG4105CC9 acyl-Coa dehydrogenase HEP85_RS18255 ENOG4105D2B acyl-CoA dehydrogenase HEP85_RS18260 ENOG4105CC9 acyl-Coa dehydrogenase HEP85_RS18270 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS18275 ENOG4107EG8 signal transduction protein with EFhand domain HEP85_RS18280 ENOG41082AN stage II sporulation protein HEP85_RS18285 ENOG4105K6V RNA polymerase HEP85_RS18335 ENOG4108XEP Alpha Beta Hydrolase Fold protein HEP85_RS18345 ENOG4108SU4 UPF0309 protein HEP85_RS18365 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEP85_RS18380 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS18420 ENOG4105CQB FAD linked oxidase domain protein HEP85_RS18455 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HEP85_RS18470 ENOG4105CPC Aldo Keto reductase HEP85_RS18485 ENOG4105XMC MarR family Transcriptional regulator HEP85_RS18495 ENOG4105C7N Xanthine uracil vitamin C permease HEP85_RS18505 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEP85_RS18530 ENOG4108N0W Major Facilitator superfamily HEP85_RS18540 ENOG4108UIH futalosine nucleosidase HEP85_RS18545 ENOG4105E63 Pfam:DUF178 HEP85_RS18550 ENOG4105VEQ Cold shock protein HEP85_RS18575 ENOG4105CFI type iii restriction protein res subunit HEP85_RS18595 ENOG4105EEM helicase HEP85_RS18600 ENOG4106N3A copper homeostasis protein cutc HEP85_RS18615 ENOG4105KNA -acetyltransferase HEP85_RS18630 ENOG4105QEK Transcriptional regulator HEP85_RS18635 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HEP85_RS18655 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HEP85_RS18675 ENOG4105C3Q Glycosyl transferase, family 2 HEP85_RS18705 ENOG4105CE4 GlcNAc 6-P deacetylase HEP85_RS18720 ENOG4105BZU Histidine kinase HEP85_RS18740 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HEP85_RS18885 ENOG4105C2N RNA methyltransferase TrmH family group 3 HEP85_RS18890 ENOG4105C8N cysteinyl-tRNA synthetase HEP85_RS18895 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HEP85_RS18900 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HEP85_RS18905 ENOG4108VJ1 Transcriptional regulator (CarD family HEP85_RS18925 ENOG4105BZU Histidine kinase HEP85_RS18950 ENOG4105CHR reductase HEP85_RS19025 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEP85_RS19030 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP85_RS19035 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEP85_RS19060 ENOG4108YZJ Pfam:DUF2596 HEP85_RS19065 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HEP85_RS19135 ENOG4107XGZ Hydrolase HEP85_RS19160 ENOG4105HHS UPF0256 protein HEP85_RS19175 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HEP85_RS19180 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HEP85_RS19190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS19195 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HEP85_RS19225 ENOG4105PKJ carbohydrate binding HEP85_RS19230 ENOG4105KHC sulfurtransferase HEP85_RS19255 ENOG4107NHD transcriptional regulator HEP85_RS19260 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS19265 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP85_RS19270 ENOG4105C0H protease HEP85_RS19295 ENOG4105BZ1 (ABC) transporter HEP85_RS19315 ENOG4105CGH 5'-nucleotidase HEP85_RS19320 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP85_RS19335 ENOG4105CJ1 ABC, transporter HEP85_RS19355 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HEP85_RS19360 ENOG4105CZV ABC transporter HEP85_RS19405 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEP85_RS19410 ENOG4105CJ3 phosphate transporter HEP85_RS19420 ENOG4105VPX protein, conserved in bacteria HEP85_RS19440 ENOG4105DNP FAD linked oxidase domain protein HEP85_RS19445 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP85_RS19450 ENOG4105E4C Lytic transglycosylase catalytic HEP85_RS19570 ENOG4105D5U fad dependent oxidoreductase HEP85_RS19575 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HEP85_RS19585 ENOG4105CPC Aldo Keto reductase HEP85_RS19615 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HEP85_RS19665 ENOG4105CQ7 ATP-dependent helicase HEP85_RS19685 ENOG4108TAC HEP85_RS19700 ENOG4105CXB phosphoribosylaminoimidazole synthetase HEP85_RS19720 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HEP85_RS19725 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HEP85_RS19730 ENOG410839H phosphoribosylformylglycinamidine synthase HEP85_RS19790 ENOG4105C12 Phosphoribosylglycinamide synthetase HEP85_RS19820 ENOG4107T65 Integrase HEP85_RS19825 ENOG4106CY5 excisionase HEP85_RS19840 ENOG4107RHI Cytosine-specific methyltransferase HEP85_RS19955 ENOG4107FW0 short-chain dehydrogenase reductase HEP85_RS19970 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HEP85_RS20025 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HEP85_RS20040 ENOG4108Z6B deaminase HEP85_RS20055 ENOG4107T65 Integrase HEP85_RS20060 ENOG4106CY5 excisionase HEP85_RS20065 ENOG4107ZVI PhiRv2 prophage protein HEP85_RS20130 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HEP85_RS20135 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS20140 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS20155 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEP85_RS20160 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP85_RS20165 ENOG4108YYC ycei family HEP85_RS20170 ENOG410905P Pyridoxamine 5-phosphate HEP85_RS20180 ENOG4105EDW glycosyl transferase, family 39 HEP85_RS20190 ENOG4105BZU Histidine kinase HEP85_RS20195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS20230 ENOG4105I6B RNA polymerase HEP85_RS20270 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS20275 ENOG4105NAF rna polymerase sigma factor HEP85_RS20300 ENOG4105X7H acyl-CoA dehydrogenase HEP85_RS20340 ENOG4108UYE Lactoylglutathione lyase HEP85_RS20360 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEP85_RS20380 ENOG4107T6F Xaa-Pro aminopeptidase HEP85_RS20425 ENOG4105DBE peroxidase HEP85_RS20435 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HEP85_RS20440 ENOG410667J hydrolase HEP85_RS20470 ENOG4105DA5 (ABC) transporter HEP85_RS20490 ENOG4107SWG transcriptional regulator MERR family HEP85_RS20495 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HEP85_RS20610 ENOG410667J hydrolase HEP85_RS20625 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEP85_RS20630 ENOG4105C4M (Ubiquinol oxidase) subunit I HEP85_RS20635 ENOG4105CIH Imidazole acetol-phosphate transaminase HEP85_RS20640 ENOG4107P2S Transcriptional regulator HEP85_RS20660 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HEP85_RS20685 ENOG4106048 Cupin 2, conserved barrel domain protein HEP85_RS20690 ENOG41082T9 Membrane HEP85_RS20695 ENOG4105KJF protein tyrosine phosphatase HEP85_RS20700 ENOG4105C28 cystathionine HEP85_RS20735 ENOG4105F27 Major Facilitator HEP85_RS20740 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HEP85_RS20755 ENOG4105CDU Replicative dna helicase HEP85_RS20765 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HEP85_RS20770 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEP85_RS20775 ENOG4107YH6 single-stranded DNA-binding protein HEP85_RS20780 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HEP85_RS20815 ENOG4105CZA synthase HEP85_RS20830 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HEP85_RS20860 ENOG4105C3M thioredoxin reductase HEP85_RS20865 ENOG4105K63 Thioredoxin HEP85_RS20880 ENOG4107QJE Chromosome Partitioning Protein HEP85_RS20885 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HEP85_RS20895 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HEP85_RS20900 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HEP85_RS20905 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HEP85_RS20915 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HEP85_RS20920 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEP85_RS20925 ENOG4108J5G 6-phosphogluconate dehydrogenase HEP85_RS20930 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HEP85_RS20935 ENOG4105K7N UPF0232 protein HEP85_RS20940 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP85_RS20945 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP85_RS20980 ENOG4108UGD Serine Threonine protein kinase HEP85_RS21010 ENOG4105ZJT Cell division protein CrgA HEP85_RS21020 ENOG4108U4N (sortase) family HEP85_RS21040 ENOG4108RN7 integral membrane protein HEP85_RS21065 ENOG4105HZM Fha domain containing protein HEP85_RS21095 ENOG41064MX Tetr family transcriptional regulator HEP85_RS21100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS21115 ENOG4108JIK carboxylase HEP85_RS21130 ENOG4105CZS beta-ketoacyl synthase HEP85_RS21175 ENOG4105D8K carboxyl transferase HEP85_RS21215 ENOG4105KVH Transcriptional regulator HEP85_RS21220 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP85_RS21240 ENOG4105DNP FAD linked oxidase domain protein HEP85_RS21260 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HEP85_RS21265 ENOG4105KVH Transcriptional regulator HEP85_RS21290 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP85_RS21295 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HEP85_RS21300 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HEP85_RS21305 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HEP85_RS21310 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HEP85_RS21335 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP85_RS21340 ENOG4108IG5 Transcriptional regulator HEP85_RS21360 ENOG4107QSN dihydrolipoamide acetyltransferase HEP85_RS21435 ENOG4105CPP Dehydrogenase, E1 component HEP85_RS21440 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HEP85_RS21510 ENOG4105ECQ AraC Family Transcriptional Regulator HEP85_RS21530 ENOG4105DFM M18 family aminopeptidase HEP85_RS21535 ENOG4105CSU acyl-Coa dehydrogenase HEP85_RS21545 ENOG4105EUB pirin domain protein HEP85_RS21560 ENOG4105C9M aspartyl-trna synthetase HEP85_RS21580 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HEP85_RS21590 ENOG4108KXM LysR family Transcriptional regulator HEP85_RS21595 ENOG4105S7M extracellular small neutral protease HEP85_RS21600 ENOG4105EM2 membrane HEP85_RS21655 ENOG4105CH2 amidohydrolase HEP85_RS21670 ENOG4105EUZ Beta-lactamase domain protein HEP85_RS21680 ENOG4105BZ4 penicillin-binding protein HEP85_RS21705 ENOG4108MUZ hydrolase HEP85_RS21715 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP85_RS21730 ENOG4105VEQ Cold shock protein HEP85_RS21760 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HEP85_RS21810 ENOG4105K6V RNA polymerase HEP85_RS21855 ENOG4108762 serine threonine protein kinase HEP85_RS21890 ENOG4105DHP deoxycytidine triphosphate deaminase HEP85_RS21925 ENOG4105DF6 Fe-S oxidoreductase HEP85_RS21935 ENOG4105CFG Acts as a chaperone (By similarity) HEP85_RS21940 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP85_RS21945 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HEP85_RS21950 ENOG4105KNI merR family transcriptional Regulator HEP85_RS21955 ENOG4105DFW ABC transporter HEP85_RS21990 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP85_RS22020 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HEP85_RS22035 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HEP85_RS22040 ENOG4107RCW fructose-bisphosphate aldolase HEP85_RS22060 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HEP85_RS22085 ENOG4108ZGX Histidine kinase HEP85_RS22090 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS22095 ENOG4105BZU Histidine kinase HEP85_RS22100 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS22110 ENOG4105DIM ABC transporter HEP85_RS22115 ENOG4105CIG ABC transporter HEP85_RS22130 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HEP85_RS22150 ENOG4105CGH 5'-nucleotidase HEP85_RS22170 ENOG4105CKK Glycosyl transferase, family 2 HEP85_RS22175 ENOG4108WYP Transcriptional regulator HEP85_RS22180 ENOG4108JPW Aminotransferase HEP85_RS22205 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HEP85_RS22210 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HEP85_RS22220 ENOG4105CFH Aspartokinase HEP85_RS22230 ENOG4105NAF rna polymerase sigma factor HEP85_RS22320 ENOG4105DDV Transcriptional regulator (LacI family HEP85_RS22345 ENOG4105BZ4 penicillin-binding protein HEP85_RS22385 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HEP85_RS22405 ENOG4105P8F nudix hydrolase HEP85_RS22420 ENOG4105D74 hydrolase HEP85_RS22430 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEP85_RS22435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP85_RS22440 ENOG4105CHH sulfate transporter HEP85_RS22500 ENOG4108I5C dEAD DEAH box helicase HEP85_RS22505 ENOG4105WN5 stage II sporulation protein HEP85_RS22510 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HEP85_RS22515 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HEP85_RS22535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEP85_RS22545 ENOG4105C6E dna polymerase iii HEP85_RS22595 ENOG4105C2M dna polymerase I HEP85_RS22635 ENOG4105C26 Dehydrogenase HEP85_RS22645 ENOG4105CVK Glutamate decarboxylase HEP85_RS22655 ENOG4107TXC Transcriptional regulator HEP85_RS22670 ENOG4105F0N pyrophosphate phospho-hydrolase HEP85_RS22685 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HEP85_RS22690 ENOG4108UGV hypoxanthine phosphoribosyltransferase HEP85_RS22700 ENOG4105EUJ GTP cyclohydrolase i HEP85_RS22730 ENOG4105CRK lysyL-tRNA synthetase HEP85_RS22755 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS22770 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS22790 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HEP85_RS22795 ENOG4108IYU L-aspartate oxidase HEP85_RS22805 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HEP85_RS22850 ENOG4105DR5 peptidase HEP85_RS22855 ENOG4108IG5 Transcriptional regulator HEP85_RS22865 ENOG4108FKE two-component system sensor kinase HEP85_RS22870 ENOG4108PYU two-component system response regulator HEP85_RS22875 ENOG41075QH Lipoprotein CseA HEP85_RS22880 ENOG4105NAF rna polymerase sigma factor HEP85_RS22895 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HEP85_RS22910 ENOG4108JWX HEP85_RS22915 ENOG4107R33 ppx gppa phosphatase HEP85_RS22920 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HEP85_RS22925 ENOG4105XEA Tetr family transcriptional regulator HEP85_RS22930 ENOG4105C01 Dihydroxy-acid dehydratase HEP85_RS22945 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HEP85_RS22965 ENOG4105CJ1 ABC, transporter HEP85_RS22975 ENOG4105II7 pyrroline-5-carboxylate reductase HEP85_RS22980 ENOG4105C31 Tryptophanyl-tRNA synthetase HEP85_RS23015 ENOG4105DGU Histone deacetylase HEP85_RS23020 ENOG4108XFF HEP85_RS23065 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HEP85_RS23070 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HEP85_RS23075 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HEP85_RS23080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HEP85_RS23085 ENOG4105D52 delta-aminolevulinic acid dehydratase HEP85_RS23120 ENOG4105DK7 lysyl-tRNA synthetase HEP85_RS23140 ENOG4105E0Y RtcB Protein HEP85_RS23170 ENOG4108UZX fmn reductase HEP85_RS23180 ENOG41062D9 Histidine kinase HEP85_RS23195 ENOG4105C0X amino acid HEP85_RS23215 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP85_RS23220 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP85_RS23225 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HEP85_RS23235 ENOG4105C0X amino acid HEP85_RS23240 ENOG4105D7N magnesium and cobalt transport protein CorA HEP85_RS23250 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HEP85_RS23255 ENOG4108RH7 phosphoglycerate mutase HEP85_RS23270 ENOG4107QIV Cytochrome c biogenesis protein HEP85_RS23275 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HEP85_RS23280 ENOG4105CRE cytochrome C HEP85_RS23315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS23325 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEP85_RS23335 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEP85_RS23355 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HEP85_RS23375 ENOG4105DVY radical SAM domain protein HEP85_RS23390 ENOG4108R86 Transcriptional regulator HEP85_RS23405 ENOG4105VEQ Cold shock protein HEP85_RS23410 ENOG4105EV6 Pfam:DUF178 HEP85_RS23425 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HEP85_RS23440 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS23450 ENOG4105KNA -acetyltransferase HEP85_RS23460 ENOG41068JE domain protein HEP85_RS23470 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23475 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEP85_RS23480 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23490 ENOG4107QIZ NADH dehydrogenase HEP85_RS23495 ENOG4108IEH NADH dehydrogenase subunit g HEP85_RS23500 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HEP85_RS23505 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23510 ENOG4105DF2 NADH dehydrogenase subunit j HEP85_RS23515 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23520 ENOG4105D65 subunit l HEP85_RS23530 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23540 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP85_RS23555 ENOG4105CAY ferredoxin--nadp reductase HEP85_RS23560 ENOG410667J hydrolase HEP85_RS23580 ENOG4105CJ1 ABC, transporter HEP85_RS23615 ENOG4105ECR NmrA family HEP85_RS23620 ENOG4105KVH Transcriptional regulator HEP85_RS23625 ENOG4105DQU oxidoreductase, subunit beta HEP85_RS23630 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HEP85_RS23650 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEP85_RS23655 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23665 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HEP85_RS23670 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23675 ENOG4107YX3 NADH dehydrogenase subunit j HEP85_RS23680 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23685 ENOG4105D65 subunit l HEP85_RS23690 ENOG4105C8S subunit m HEP85_RS23695 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEP85_RS23700 ENOG4105D0M Protease HtpX homolog HEP85_RS23720 ENOG4105Y3U Transglycosylase-associated protein HEP85_RS23725 ENOG4108VPT UPF0234 protein HEP85_RS23760 ENOG4105WDJ 50S ribosomal protein L33 HEP85_RS23765 ENOG410900P UPF0336 protein HEP85_RS23785 ENOG4107R4N Cell wall formation (By similarity) HEP85_RS23790 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HEP85_RS23795 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP85_RS23815 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HEP85_RS23820 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HEP85_RS23825 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HEP85_RS23835 ENOG4105QCJ Lipoprotein HEP85_RS23840 ENOG4108VZM 50s ribosomal protein L10 HEP85_RS23845 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HEP85_RS23850 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP85_RS23855 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP85_RS23890 ENOG4105EYW Ion transport protein HEP85_RS23895 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HEP85_RS23900 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HEP85_RS23905 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HEP85_RS23910 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HEP85_RS23915 ENOG4106A3M Cytochrome p-450 HEP85_RS23950 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HEP85_RS23955 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HEP85_RS23960 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HEP85_RS23965 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HEP85_RS23970 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HEP85_RS23975 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HEP85_RS23980 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HEP85_RS23985 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HEP85_RS23990 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HEP85_RS23995 ENOG41082SA 50s ribosomal protein l29 HEP85_RS24000 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HEP85_RS24005 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HEP85_RS24010 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HEP85_RS24015 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HEP85_RS24020 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HEP85_RS24030 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HEP85_RS24035 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HEP85_RS24040 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HEP85_RS24045 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HEP85_RS24050 ENOG410849U 50S ribosomal protein L30 HEP85_RS24055 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HEP85_RS24065 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HEP85_RS24075 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEP85_RS24080 ENOG41067V7 50S ribosomal protein L36 HEP85_RS24085 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HEP85_RS24090 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HEP85_RS24095 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEP85_RS24100 ENOG4108ZT0 50S ribosomal protein l17 HEP85_RS24105 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HEP85_RS24115 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HEP85_RS24120 ENOG4108UJD 30S ribosomal protein S9 HEP85_RS24125 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HEP85_RS24135 ENOG4105CS9 pantothenic acid kinase HEP85_RS24140 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEP85_RS24165 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HEP85_RS24170 ENOG4108097 ATP-binding protein HEP85_RS24195 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HEP85_RS24205 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEP85_RS24215 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP85_RS24220 ENOG4105XN3 extracellular solute-binding protein family 1 HEP85_RS24225 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS24230 ENOG4107TB5 TRANSCRIPTIONal HEP85_RS24245 ENOG4105CHP RNA polymerase HEP85_RS24265 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HEP85_RS24270 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HEP85_RS24275 ENOG4105EMU Dehydrogenase HEP85_RS24285 ENOG4105DND Transcriptional regulator HEP85_RS24290 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP85_RS24300 ENOG4108MMM RNA Polymerase HEP85_RS24310 ENOG4107QVP Dehydrogenase HEP85_RS24315 ENOG4107QQG Dehydrogenase HEP85_RS24320 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEP85_RS24340 ENOG4107TPY serine threonine protein kinase HEP85_RS24345 ENOG4108UGD Serine Threonine protein kinase HEP85_RS24350 ENOG4107TPY serine threonine protein kinase HEP85_RS24355 ENOG4105C26 Dehydrogenase HEP85_RS24380 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HEP85_RS24425 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS24435 ENOG4105K4H Nlp p60 protein HEP85_RS24460 ENOG4105DR5 peptidase HEP85_RS24485 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP85_RS24495 ENOG4105DEG Vwa containing coxe family protein HEP85_RS24505 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEP85_RS24535 ENOG4105DC1 bifunctional purine biosynthesis protein purh HEP85_RS24565 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HEP85_RS24600 ENOG4108IJ7 Glycine betaine HEP85_RS24605 ENOG4108HQS Glycine betaine HEP85_RS24615 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP85_RS24635 ENOG4106032 Glutathionylspermidine synthase HEP85_RS24640 ENOG4105C8Y Acetylornithine aminotransferase HEP85_RS24645 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP85_RS24660 ENOG4105EMN RNA polymerase sigma factor HEP85_RS24665 ENOG4105C31 Tryptophanyl-tRNA synthetase HEP85_RS24695 ENOG4107H3J ribonuclease HEP85_RS24710 ENOG4107RN3 metallophosphoesterase HEP85_RS24720 ENOG4105BZU Histidine kinase HEP85_RS24725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS24730 ENOG4105EYF MMPL domain protein HEP85_RS24740 ENOG4105U5Y Transcriptional regulator HEP85_RS24775 ENOG4108J01 L-aspartate oxidase HEP85_RS24795 ENOG4105E2D ec 3.2.1.52 HEP85_RS24825 ENOG4108MMM RNA Polymerase HEP85_RS24845 ENOG4108MMM RNA Polymerase HEP85_RS24870 ENOG4108NIW Leucine export protein LeuE HEP85_RS24900 ENOG4105K64 Glycosyl transferase, family 2 HEP85_RS24915 ENOG4105D2T synthase HEP85_RS24970 ENOG4107RM1 amidohydrolase HEP85_RS24975 ENOG4105DIH basic membrane HEP85_RS24985 ENOG4105DIH basic membrane HEP85_RS24990 ENOG4108JQ9 ABC transporter HEP85_RS25030 ENOG4105D94 Major Facilitator Superfamily HEP85_RS25035 ENOG4107RSM transcriptional regulator HEP85_RS25045 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP85_RS25070 ENOG41065SU Two-component system sensor kinase HEP85_RS25075 ENOG4108KXV response regulator HEP85_RS25080 ENOG4105NAF rna polymerase sigma factor HEP85_RS25095 ENOG4105C26 Dehydrogenase HEP85_RS25100 ENOG4105C26 Dehydrogenase HEP85_RS25105 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HEP85_RS25120 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HEP85_RS25145 ENOG4108JIK carboxylase HEP85_RS25155 ENOG4107WR6 Maf-like protein HEP85_RS25170 ENOG4105D8K carboxyl transferase HEP85_RS25180 ENOG4108QER Adenylate cyclase HEP85_RS25185 ENOG4105E39 Enoyl-CoA hydratase HEP85_RS25195 ENOG4105C84 Histidine ammonia-lyase HEP85_RS25200 ENOG4105VEQ Cold shock protein HEP85_RS25235 ENOG4105C19 ABC transporter HEP85_RS25255 ENOG4105DQ4 alcohol dehydrogenase HEP85_RS25280 ENOG4105G6Z alkaline phosphatase HEP85_RS25355 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HEP85_RS25375 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEP85_RS25380 ENOG4105C7B Threonine dehydratase HEP85_RS25395 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEP85_RS25405 ENOG4105T1M mycothiol conjugate amidase mca HEP85_RS25425 ENOG4105C7Z Conserved Protein HEP85_RS25460 ENOG4105C57 major facilitator superfamily HEP85_RS25470 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HEP85_RS25495 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP85_RS25510 ENOG4105CHM Aminotransferase HEP85_RS25535 ENOG4108FUF Transcriptional regulator, IclR family HEP85_RS25540 ENOG4105KME endoribonuclease L-psp HEP85_RS25545 ENOG4105C6Z Gluconate HEP85_RS25640 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS25660 ENOG4107QKZ Ompa motb domain protein HEP85_RS25665 ENOG4105NAE bifunctional deaminase-reductase domain protein HEP85_RS25710 ENOG4105CPC Aldo Keto reductase HEP85_RS25715 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HEP85_RS25720 ENOG4108IAB Phoh family HEP85_RS25725 ENOG4106770 Is able to cleave peptidoglycan (By similarity) HEP85_RS25735 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEP85_RS25740 ENOG4105D3R alkyl hydroperoxide reductase HEP85_RS25755 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP85_RS25775 ENOG4108JQC penicillin-binding protein 1A HEP85_RS25780 ENOG4105CH6 catalase HEP85_RS25795 ENOG4105C9Q fumarate hydratase class II HEP85_RS25815 ENOG4107GFK fumarate HEP85_RS25825 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP85_RS25840 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP85_RS25845 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEP85_RS25850 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEP85_RS25855 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HEP85_RS25870 ENOG4105C3G gtp-binding protein HEP85_RS25875 ENOG41084HI prevent-host-death family HEP85_RS25880 ENOG4105KRQ Addiction module toxin, Txe YoeB family HEP85_RS25885 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HEP85_RS25940 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEP85_RS25960 ENOG4105CI3 gtp-binding protein typa HEP85_RS25965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS25980 ENOG4105C3U ABC transporter HEP85_RS25985 ENOG4108JQ7 (ABC) transporter HEP85_RS25990 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEP85_RS26040 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP85_RS26045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS26055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP85_RS26060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS26065 ENOG4105C3U ABC transporter HEP85_RS26070 ENOG4108JQ7 (ABC) transporter HEP85_RS26090 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP85_RS26110 ENOG4108M15 ABC transporter HEP85_RS26120 ENOG4105BZU Histidine kinase HEP85_RS26125 ENOG4108S01 response regulator HEP85_RS26140 ENOG4108Z4U Ferredoxin HEP85_RS26160 ENOG4107R4C succinyl-diaminopimelate desuccinylase HEP85_RS26165 ENOG4108URH decarboxylase HEP85_RS26180 ENOG4108R3E Dna-3-methyladenine glycosylase i HEP85_RS26185 ENOG4105CGU Enoyl-CoA hydratase HEP85_RS26200 ENOG4105DU6 RNA polymerase HEP85_RS26215 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEP85_RS26240 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HEP85_RS26250 ENOG4105D7N magnesium and cobalt transport protein CorA HEP85_RS26260 ENOG4105DXB Major Facilitator superfamily HEP85_RS26275 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HEP85_RS26335 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP85_RS26340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS26405 ENOG4105C4R Atp-dependent dna helicase HEP85_RS26410 ENOG4107QSE Dipeptidase HEP85_RS26435 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP85_RS26505 ENOG41063PX domain protein HEP85_RS26515 ENOG4105DJZ UPF0182 protein HEP85_RS26550 ENOG4107TK4 histidinol-phosphate phosphatase HEP85_RS26570 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HEP85_RS26580 ENOG4108RAV Conserved protein HEP85_RS26590 ENOG4105EMN RNA polymerase sigma factor HEP85_RS26595 ENOG4105WMN AntiSigma factor HEP85_RS26615 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP85_RS26625 ENOG41068W2 Cytochrome p-450 HEP85_RS26650 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP85_RS26655 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP85_RS26675 ENOG4105FDP GntR family transcriptional regulator HEP85_RS26695 ENOG4105D17 glycoside hydrolase, family 3 domain protein HEP85_RS26700 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HEP85_RS26715 ENOG4105CBD Diacylglycerol kinase HEP85_RS26745 ENOG4105K6H D-cysteine desulfhydrase HEP85_RS26760 ENOG4105ESN nucleotide-binding protein HEP85_RS26770 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP85_RS26840 ENOG4108VEQ Superoxide dismutase HEP85_RS26855 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEP85_RS26860 ENOG4105CDA abc transporter atp-binding protein HEP85_RS26865 ENOG4105E5Q amino acid AbC transporter HEP85_RS26870 ENOG4105EAB amino acid AbC transporter HEP85_RS26875 ENOG4105C6K Malic enzyme HEP85_RS26880 ENOG4105CB2 alcohol dehydrogenase HEP85_RS26920 ENOG4105EB3 Histidine kinase HEP85_RS26925 ENOG4108PYU two-component system response regulator HEP85_RS26940 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HEP85_RS26980 ENOG4107R16 Multicopper oxidase HEP85_RS26995 ENOG4108IG5 Transcriptional regulator HEP85_RS27020 ENOG4105CJN penicillin-binding protein HEP85_RS27025 ENOG4107QHZ cell cycle protein HEP85_RS27050 ENOG4105IU0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEP85_RS27060 ENOG4105FDF Could be involved in DNA repair (By similarity) HEP85_RS27065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEP85_RS27070 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS27085 ENOG4105E2A Dehydrogenase HEP85_RS27165 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HEP85_RS27170 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HEP85_RS27200 ENOG4105CVR type I restriction-modification system HEP85_RS27205 ENOG4105FDP GntR family transcriptional regulator HEP85_RS27250 ENOG4105CNU cell division protein FtsK HEP85_RS27270 ENOG4107RHI Cytosine-specific methyltransferase HEP85_RS27310 ENOG4105C75 arginyL-tRNA synthetase HEP85_RS27315 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HEP85_RS27320 ENOG4105D6E homoserine dehydrogenase HEP85_RS27325 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HEP85_RS27330 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HEP85_RS27340 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP85_RS27345 ENOG4108RCF TRANSCRIPTIONal HEP85_RS27350 ENOG4105VFB Binds the 23S rRNA (By similarity) HEP85_RS27355 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HEP85_RS27360 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP85_RS27370 ENOG4107ZF2 Phosphatase HEP85_RS27375 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP85_RS27380 ENOG4105ESV Glycosyl transferase, family 4 HEP85_RS27385 ENOG4105Z3P ATP synthase HEP85_RS27395 ENOG4105ZA1 atp synthase HEP85_RS27400 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HEP85_RS27405 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HEP85_RS27410 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HEP85_RS27415 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HEP85_RS27420 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HEP85_RS27425 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HEP85_RS27445 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP85_RS27460 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HEP85_RS27505 ENOG4105CJ1 ABC, transporter HEP85_RS27525 ENOG4105CHU acetyl-coa acetyltransferase HEP85_RS27540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS27545 ENOG41062D9 Histidine kinase HEP85_RS27585 ENOG4105WX6 Membrane HEP85_RS27625 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEP85_RS27630 ENOG4105C6K Malic enzyme HEP85_RS27635 ENOG4105CTQ phosphohexokinase HEP85_RS27660 ENOG4108MRH transcriptional regulatory protein HEP85_RS27670 ENOG4105CK2 sodium dicarboxylate symporter HEP85_RS27695 ENOG4105C3M thioredoxin reductase HEP85_RS27730 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEP85_RS27765 ENOG4105BZ1 (ABC) transporter HEP85_RS27770 ENOG4105BZ1 (ABC) transporter HEP85_RS27775 ENOG4105BZ1 (ABC) transporter HEP85_RS27790 ENOG4105BZU Histidine kinase HEP85_RS27795 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS27805 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HEP85_RS27810 ENOG41069FZ L,D-transpeptidase catalytic domain HEP85_RS27845 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HEP85_RS27880 ENOG4105EJQ L-serine dehydratase HEP85_RS27885 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEP85_RS27890 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HEP85_RS27895 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HEP85_RS27915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS27920 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP85_RS27925 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP85_RS27930 ENOG4105C3U ABC transporter HEP85_RS27935 ENOG4108JQ7 (ABC) transporter HEP85_RS27945 ENOG4105EN6 Membrane HEP85_RS27985 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HEP85_RS27995 ENOG4108URH decarboxylase HEP85_RS28000 ENOG4105EMU Dehydrogenase HEP85_RS28010 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP85_RS28015 ENOG4105BZU Histidine kinase HEP85_RS28020 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HEP85_RS28025 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HEP85_RS28035 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HEP85_RS28040 ENOG4105D9U N-acetyltransferase HEP85_RS28055 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS28070 ENOG4108FN7 Aldo keto reductase HEP85_RS28085 ENOG4105BZU Histidine kinase HEP85_RS28095 ENOG4108ZP8 Acetolactate synthase small subunit HEP85_RS28100 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HEP85_RS28115 ENOG4105C57 major facilitator superfamily HEP85_RS28135 ENOG4105C26 Dehydrogenase HEP85_RS28150 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HEP85_RS28155 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEP85_RS28180 ENOG4105CQM Urea amidohydrolase subunit alpha HEP85_RS28185 ENOG4105DWY Agmatine deiminase HEP85_RS28195 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP85_RS28225 ENOG4105D8K carboxyl transferase HEP85_RS28245 ENOG4105GWZ Roadblock lc7 family protein HEP85_RS28265 ENOG4105GWZ Roadblock lc7 family protein HEP85_RS28280 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HEP85_RS28285 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HEP85_RS28345 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEP85_RS28350 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEP85_RS28360 ENOG4105K70 DNA-binding protein HEP85_RS28380 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP85_RS28385 ENOG4105CPF Cell wall formation (By similarity) HEP85_RS28405 ENOG4105VB9 50S ribosomal protein l28 HEP85_RS28420 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HEP85_RS28425 ENOG4105CB5 ATP-dependent DNA helicase recG HEP85_RS28430 ENOG4106H78 methyltransferase HEP85_RS28435 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HEP85_RS28450 ENOG41084BZ 50S ribosomal protein L32 HEP85_RS28455 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HEP85_RS28460 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HEP85_RS28465 ENOG4105KVH Transcriptional regulator HEP85_RS28485 ENOG4105K4I Scp-like extracellular HEP85_RS28490 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HEP85_RS28555 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEP85_RS28565 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HEP85_RS28575 ENOG4105K5M 30s ribosomal protein S16 HEP85_RS28580 ENOG41082KU UPF0109 protein HEP85_RS28585 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HEP85_RS28590 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HEP85_RS28595 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HEP85_RS28605 ENOG4107QYR Signal peptidase i HEP85_RS28615 ENOG4107QYR Signal peptidase i HEP85_RS28620 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HEP85_RS28630 ENOG41080R2 UPF0102 protein HEP85_RS28645 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS28660 ENOG4105CE9 30S ribosomal protein S2 HEP85_RS28665 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HEP85_RS28670 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HEP85_RS28675 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HEP85_RS28695 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HEP85_RS28705 ENOG4105ECW sulfate abc transporter HEP85_RS28710 ENOG4108UCS ABC, transporter HEP85_RS28735 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HEP85_RS28740 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEP85_RS28750 ENOG4105C26 Dehydrogenase HEP85_RS28810 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEP85_RS28815 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEP85_RS28840 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEP85_RS28845 ENOG4105F38 ABC transporter, permease HEP85_RS28850 ENOG4105D38 putrescine abc transporter HEP85_RS28885 ENOG4105G9B Transcriptional regulator HEP85_RS28885 ENOG4105G9B Transcriptional regulator HEP85_RS28930 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HEP85_RS28935 ENOG4105DZP Membrane-associated zinc metalloprotease HEP85_RS28940 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HEP85_RS28955 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HEP85_RS28960 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HEP85_RS28975 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HEP85_RS29000 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HEP85_RS29005 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HEP85_RS29025 ENOG4108JQ7 (ABC) transporter HEP85_RS29035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS29040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP85_RS29070 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin HEP85_RS29125 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HEP85_RS29130 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HEP85_RS29135 ENOG4105C1V Peptidase, M16 HEP85_RS29140 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HEP85_RS29165 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEP85_RS29170 ENOG4105CN5 Metallo-Beta-Lactamase HEP85_RS29190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HEP85_RS29210 ENOG4105BZU Histidine kinase HEP85_RS29215 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HEP85_RS29220 ENOG4107QZI cell division protein FtsK HEP85_RS29230 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HEP85_RS29240 ENOG4105CEV competence damage-inducible protein HEP85_RS29245 ENOG4105WBV Transcriptional regulator HEP85_RS29250 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HEP85_RS29255 ENOG4105CHR reductase HEP85_RS29260 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HEP85_RS29270 ENOG4106AXJ AraC family transcriptional regulator HEP85_RS29305 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HEP85_RS29315 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HEP85_RS29325 ENOG4107SCK Monooxygenase HEP85_RS29330 ENOG4105DRP amino acid AbC transporter HEP85_RS29335 ENOG4108Q1T ABC transporter HEP85_RS29340 ENOG4107UBR Extracellular solute-binding protein family 3 HEP85_RS29345 ENOG4105CDA abc transporter atp-binding protein HEP85_RS29350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS29360 ENOG4105H1G trap transporter solute receptor taxi family HEP85_RS29380 ENOG4105BZU Histidine kinase HEP85_RS29385 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS29405 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS29410 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HEP85_RS29430 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HEP85_RS29440 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HEP85_RS29445 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEP85_RS29455 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HEP85_RS29495 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HEP85_RS29500 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HEP85_RS29505 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEP85_RS29540 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HEP85_RS29555 ENOG4105C9U ATP-dependent DNA helicase RecQ HEP85_RS29570 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEP85_RS29580 ENOG4105C6F GntR Family Transcriptional Regulator HEP85_RS29585 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS29600 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP85_RS29615 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS29625 ENOG4107QN1 sodium solute HEP85_RS29630 ENOG4108MRH transcriptional regulatory protein HEP85_RS29640 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HEP85_RS29650 ENOG4108MRH transcriptional regulatory protein HEP85_RS29665 ENOG4105BZN citrate synthase HEP85_RS29670 ENOG4105BZN citrate synthase HEP85_RS29690 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP85_RS29705 ENOG4105DR5 peptidase HEP85_RS29710 ENOG4105DRR Transcriptional regulator, GntR family HEP85_RS29715 ENOG410849S phosphocarrier protein (HPr) HEP85_RS29740 ENOG4107W53 thymidine kinase HEP85_RS29775 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HEP85_RS29790 ENOG4105F44 Two component transcriptional regulator, winged helix family HEP85_RS29795 ENOG4106F60 Histidine kinase HEP85_RS29820 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HEP85_RS29835 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HEP85_RS29870 ENOG4107VEG TrkA-N domain protein HEP85_RS29875 ENOG4105C0X amino acid HEP85_RS29880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HEP85_RS29915 ENOG4105F4R Transcriptional regulator mode HEP85_RS29945 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP85_RS29955 ENOG4107S1Q Phosphatase HEP85_RS29970 ENOG4105CEU Arginine dihydrolase HEP85_RS29975 ENOG4105DBV ornithine carbamoyltransferase HEP85_RS29980 ENOG4105CUB amino acid HEP85_RS29990 ENOG4105CGU Enoyl-CoA hydratase HEP85_RS30030 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HEP85_RS30045 ENOG4105CHR reductase HEP85_RS30060 ENOG4107QM5 aconitate hydratase HEP85_RS30065 ENOG4105CWX Alpha-1,2-mannosidase HEP85_RS30090 ENOG4105E2R ROK family HEP85_RS30095 ENOG4105DFW ABC transporter HEP85_RS30100 ENOG4105C2J ABC transporter HEP85_RS30105 ENOG4108HWW ABC transporter HEP85_RS30110 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HEP85_RS30115 ENOG4105CUB amino acid HEP85_RS30135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP85_RS30140 ENOG4105CHU acetyl-coa acetyltransferase HEP85_RS30145 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HEP85_RS30160 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HEP85_RS30175 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HEP85_RS30185 ENOG4105C1Q protoporphyrinogen oxidase HEP85_RS30190 ENOG4107JTW chlorite dismutase HEP85_RS30210 ENOG4105E18 UPF0276 protein HEP85_RS30255 ENOG4105EMU Dehydrogenase HEP85_RS30260 ENOG4105CSR polyphosphate kinase 2 HEP85_RS30290 ENOG4105DFU Cell wall formation (By similarity) HEP85_RS30295 ENOG4105E0X reductase HEP85_RS30430 ENOG4105ZSU inhibitor HEP85_RS30500 ENOG4107WA4 MmpL domain-containing protein HEP85_RS30515 ENOG4107S5I aldo keto reductase HEP85_RS30530 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP85_RS30540 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP85_RS30545 ENOG4108IY8 ABC, transporter HEP85_RS30575 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HEP85_RS30620 ENOG4105E7U AraC family transcriptional regulator HEP85_RS30655 ENOG4108VQT Alpha beta hydrolase fold protein HEP85_RS30680 ENOG4105QE3 oxidoreductase HEP85_RS30705 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HEP85_RS30745 ENOG4105C7K acetolactate synthase HEP85_RS30765 ENOG4105DRR Transcriptional regulator, GntR family HEP85_RS30795 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HEP85_RS30800 ENOG4105C7N Xanthine uracil vitamin C permease HEP85_RS30820 ENOG4108ZJ4 polysaccharide deacetylase HEP85_RS30835 ENOG4108YIQ Alpha beta hydrolase HEP85_RS30870 ENOG4105PGM cation diffusion facilitator family transporter HEP85_RS30885 ENOG41082SX arsR family transcriptional regulator HEP85_RS30905 ENOG4106CD9 glycosyl transferase group 1 HEP85_RS30910 ENOG4108QV3 biosynthesis protein HEP85_RS30925 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HEP85_RS30930 ENOG4107STW synthase HEP85_RS30945 ENOG4105C0K Gdp-mannose 4,6-dehydratase HEP85_RS30950 ENOG4105C30 Nad-dependent epimerase dehydratase HEP85_RS30955 ENOG4105D3Q Sugar transferase HEP85_RS30960 ENOG4108KGH TRANSCRIPTIONal HEP85_RS31000 ENOG4105NAE bifunctional deaminase-reductase domain protein HEP85_RS31005 ENOG4105D7N magnesium and cobalt transport protein CorA HEP85_RS31015 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HEP85_RS31030 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP85_RS31035 ENOG4105CEY Amp-dependent synthetase and ligase HEP85_RS31045 ENOG41060W2 glyoxylate carboligase HEP85_RS31060 ENOG4105CH6 catalase HEP85_RS31065 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HEP85_RS31070 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HEP85_RS31090 ENOG4105VT2 5-hydroxyisourate hydrolase HEP85_RS31100 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP85_RS31120 ENOG4105KVH Transcriptional regulator HEP85_RS31130 ENOG4108ZM9 phosphoglycerate mutase HEP85_RS31150 ENOG4105CHM Aminotransferase HEP85_RS31185 ENOG4106YT9 Enoyl-CoA hydratase HEP85_RS31190 ENOG4106A3M Cytochrome p-450 HEP85_RS31205 ENOG4107R9S Malate synthase HEP85_RS31210 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HEP85_RS31220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEP85_RS31225 ENOG4107HP6 Transcriptional regulator HEP85_RS31240 ENOG4105D7N magnesium and cobalt transport protein CorA HEP85_RS31260 ENOG4105CPC Aldo Keto reductase HEP85_RS31275 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEP85_RS31295 ENOG4105CNN ABC, transporter HEP85_RS31300 ENOG4105C2J ABC transporter HEP85_RS31305 ENOG4105DKQ ROK family HEP85_RS31325 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS31340 ENOG4107QNJ CoA-transferase subunit B HEP85_RS31350 ENOG4107RQ0 Maleylacetate reductase HEP85_RS31375 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HEP85_RS31380 ENOG4105E8R UPF0173 metal-dependent hydrolase HEP85_RS31395 ENOG4105CDA abc transporter atp-binding protein HEP85_RS31405 ENOG4105EAD ABC transporter HEP85_RS31410 ENOG4105DRP amino acid AbC transporter HEP85_RS31425 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HEP85_RS31455 ENOG4105C8Y Acetylornithine aminotransferase HEP85_RS31470 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HEP85_RS31480 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HEP85_RS31490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS31500 ENOG4105BZU Histidine kinase HEP85_RS31535 ENOG4105HSS phospholipase C HEP85_RS31545 ENOG4108UVJ appr-1-p processing domain protein HEP85_RS31570 ENOG4105CHR reductase HEP85_RS31575 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS31580 ENOG4105NN7 muconolactone delta-isomerase HEP85_RS31590 ENOG41060BG Tetr family transcriptional regulator HEP85_RS31625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS31630 ENOG4105BZU Histidine kinase HEP85_RS31670 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEP85_RS31675 ENOG4105DQR SNARE associated Golgi HEP85_RS31710 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HEP85_RS31750 ENOG4105BZW Glycerate kinase HEP85_RS31760 ENOG4108IV0 ABC, transporter HEP85_RS31770 ENOG4105C32 Amino acid ABC transporter (Permease) HEP85_RS31775 ENOG4105C32 Amino acid ABC transporter (Permease) HEP85_RS31790 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HEP85_RS31795 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS31805 ENOG4105CI0 Citrate lyase HEP85_RS31825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP85_RS31835 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HEP85_RS31845 ENOG4106JDR secreted HEP85_RS31865 ENOG4108Q50 Histidine kinase HEP85_RS31905 ENOG4108ME1 Peptidase M55 D-aminopeptidase HEP85_RS31920 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HEP85_RS31945 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS31955 ENOG4105C5H ABC transporter HEP85_RS32025 ENOG4105CFG Acts as a chaperone (By similarity) HEP85_RS32045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEP85_RS32050 ENOG4107MII Sugar-specific transcriptional regulator TrmB HEP85_RS32070 ENOG410842T Pterin carbinolamine dehydratase HEP85_RS32075 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS32090 ENOG4105D29 Helix-turn-helix type 11 domain protein HEP85_RS32115 ENOG4105CV8 reductase HEP85_RS32130 ENOG4105DUM transcriptional regulator, lysR family HEP85_RS32135 ENOG4105DHU Bile acid HEP85_RS32145 ENOG4105D3W isochorismatase HEP85_RS32150 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HEP85_RS32155 ENOG4107QHI -hydrogenase HEP85_RS32165 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HEP85_RS32170 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEP85_RS32175 ENOG4107S5I aldo keto reductase HEP85_RS32205 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEP85_RS32230 ENOG4105CNN ABC, transporter HEP85_RS32235 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP85_RS32305 ENOG4105FCD Major Facilitator HEP85_RS32325 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEP85_RS32335 ENOG4105C26 Dehydrogenase HEP85_RS32380 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEP85_RS32425 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEP85_RS32430 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEP85_RS32465 ENOG4105BZP glycoside hydrolase 15-related HEP85_RS32485 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HEP85_RS32520 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP85_RS32525 ENOG4105CHR reductase HEP85_RS32535 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB HEP85_RS32575 ENOG4108YYC ycei family HEP85_RS32585 ENOG4105DRP amino acid AbC transporter HEP85_RS32590 ENOG4105CDA abc transporter atp-binding protein HEP85_RS32615 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS32650 ENOG4107QJN gtp cyclohydrolase ii HEP85_RS32655 ENOG4105F84 Ornithine cyclodeaminase HEP85_RS32680 ENOG410905P Pyridoxamine 5-phosphate HEP85_RS32695 ENOG4108ZM9 phosphoglycerate mutase HEP85_RS32705 ENOG4107QP8 phosphohexose isomerase HEP85_RS32720 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEP85_RS32750 ENOG41088CQ domain protein HEP85_RS32760 ENOG4105F8D glycoside hydrolase family 4 HEP85_RS32765 ENOG4106UDK Cellulose-binding, family II HEP85_RS32825 ENOG4105MWK D-amino acid dehydrogenase, small subunit HEP85_RS32835 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HEP85_RS32845 ENOG4105CTU Proline racemase HEP85_RS32865 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP85_RS32870 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HEP85_RS32875 ENOG4105CG3 alpha amylase, catalytic region HEP85_RS32890 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HEP85_RS32895 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEP85_RS32920 ENOG4106YT9 Enoyl-CoA hydratase HEP85_RS32930 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HEP85_RS32935 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS32950 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS32960 ENOG4106YT9 Enoyl-CoA hydratase HEP85_RS32970 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HEP85_RS33000 ENOG4105VEQ Cold shock protein HEP85_RS33065 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HEP85_RS33070 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HEP85_RS33100 ENOG4108R5T secreted protein HEP85_RS33110 ENOG4105DQE DNA ligase HEP85_RS33115 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS33125 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HEP85_RS33175 ENOG4106V2I dimethylaminohydrolase HEP85_RS33180 ENOG4105C5H ABC transporter HEP85_RS33190 ENOG4105KF0 sporulation and cell division protein, SsgA HEP85_RS33200 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HEP85_RS33210 ENOG4105EG6 Saccharopine dehydrogenase HEP85_RS33215 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HEP85_RS33220 ENOG4105C1G acyl-Coa dehydrogenase HEP85_RS33225 ENOG4105CHU acetyl-coa acetyltransferase HEP85_RS33230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEP85_RS33275 ENOG4105C5H ABC transporter HEP85_RS33285 ENOG4105BZM domain protein HEP85_RS33305 ENOG4105E39 Enoyl-CoA hydratase HEP85_RS33315 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HEP85_RS33345 ENOG4108MDK Dehydrogenase HEP85_RS33365 ENOG4105EY8 ABC transporter HEP85_RS33370 ENOG4105FBD synthase HEP85_RS33380 ENOG4107S11 squalene-associated FAD-dependent desaturase HEP85_RS33390 ENOG4105EWU Squalene--hopene cyclase HEP85_RS33405 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HEP85_RS33430 ENOG4105M2Z protein tyrosine serine phosphatase HEP85_RS33440 ENOG41090WU lipolytic protein G-D-S-L family HEP85_RS33450 ENOG4105D82 Glutamate dehydrogenase HEP85_RS33485 ENOG4105CK5 oxidoreductase HEP85_RS33490 ENOG4105CPQ Dehydrogenase HEP85_RS33495 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HEP85_RS33500 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS33565 ENOG4105C0F tryptophanase EC 4.1.99.1 HEP85_RS33580 ENOG4105QEK Transcriptional regulator HEP85_RS33585 ENOG4108SU4 UPF0309 protein HEP85_RS33655 ENOG4105DWF phosphomethylpyrimidine kinase HEP85_RS33665 ENOG4105EW9 transcriptional regulator AsnC family HEP85_RS33685 ENOG4108YZG isomerase HEP85_RS33715 ENOG41079R3 acyl carrier protein HEP85_RS33725 ENOG4105KTE polyketide synthesis cyclase HEP85_RS33740 ENOG4105E9K Isocitrate dehydrogenase HEP85_RS33745 ENOG4105D64 Mechanosensitive ion channel HEP85_RS33750 ENOG41060WC Enoyl-CoA hydratase HEP85_RS33760 ENOG4105BZ1 (ABC) transporter HEP85_RS33765 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HEP85_RS33770 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEP85_RS33790 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HEP85_RS33795 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HEP85_RS33805 ENOG4105C57 major facilitator superfamily HEP85_RS33810 ENOG4105CIG ABC transporter HEP85_RS33825 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HEP85_RS33845 ENOG4105CPQ Dehydrogenase HEP85_RS33855 ENOG4105BZP glycoside hydrolase 15-related HEP85_RS33865 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HEP85_RS33880 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEP85_RS33905 ENOG4107QPH glycogen) synthase HEP85_RS33910 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HEP85_RS33925 ENOG4105CHR reductase HEP85_RS33935 ENOG4108M4U conserved membrane protein HEP85_RS34010 ENOG41073TP transcriptional regulator HEP85_RS34020 ENOG4105C2J ABC transporter HEP85_RS34025 ENOG4105CNN ABC, transporter HEP85_RS34030 ENOG4105DIA mandelate racemase muconate lactonizing HEP85_RS34100 ENOG4108ZJ4 polysaccharide deacetylase HEP85_RS34135 ENOG4105BZU Histidine kinase HEP85_RS34140 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS34150 ENOG4105CHR reductase HEP85_RS34155 ENOG4105C5Q Transcriptional regulator HEP85_RS34170 ENOG4105E33 succinate dehydrogenase HEP85_RS34180 ENOG4108Z20 Acyl-transferase HEP85_RS34195 ENOG4105DEN Luciferase family HEP85_RS34205 ENOG4105CPC Aldo Keto reductase HEP85_RS34230 ENOG4105DU6 RNA polymerase HEP85_RS34240 ENOG4105WKW Pfam:DUF1458 HEP85_RS34265 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid HEP85_RS34280 ENOG41067HS methyltransferase HEP85_RS34285 ENOG4108V75 Glutamine amidotransferase HEP85_RS34290 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HEP85_RS34295 ENOG4105D1K glutamate--cysteine ligase HEP85_RS34310 ENOG4105DZ6 Band 7 protein HEP85_RS34325 ENOG41060NJ transcriptional regulator HEP85_RS34340 ENOG41080RH Thioredoxin HEP85_RS34350 ENOG4105C5H ABC transporter HEP85_RS34355 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HEP85_RS34390 ENOG4105EUB pirin domain protein HEP85_RS34435 ENOG4105D3W isochorismatase HEP85_RS34440 ENOG41080V3 Major Facilitator superfamily HEP85_RS34450 ENOG4107SET aldo keto reductase HEP85_RS34460 ENOG4105C9Q fumarate hydratase class II HEP85_RS34470 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS34535 ENOG410841Q phosphoesterase PA-phosphatase related protein HEP85_RS34565 ENOG4108W5M transcriptional regulator HEP85_RS34575 ENOG4105FDP GntR family transcriptional regulator HEP85_RS34675 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HEP85_RS34700 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HEP85_RS34705 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HEP85_RS34725 ENOG4105EX0 alpha-galactosidase HEP85_RS34735 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HEP85_RS34755 ENOG4105JXH GntR family transcriptional regulator HEP85_RS34760 ENOG4105CXK mandelate racemase muconate lactonizing HEP85_RS34770 ENOG4108UHU Aldolase HEP85_RS34795 ENOG4105F27 Major Facilitator HEP85_RS34810 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS34835 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS34985 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP85_RS34995 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS35000 ENOG4105BZU Histidine kinase HEP85_RS35030 ENOG4106UDK Cellulose-binding, family II HEP85_RS35065 ENOG4108Q50 Histidine kinase HEP85_RS35100 ENOG4105DPX Hydrogenase, large subunit HEP85_RS35125 ENOG4108USZ hydrogenase HEP85_RS35150 ENOG4105CQS hydrogenase expression formation protein HypD HEP85_RS35170 ENOG4105E90 ABC transporter HEP85_RS35175 ENOG4105E90 ABC transporter HEP85_RS35185 ENOG4108IJ8 ABC transporter HEP85_RS35190 ENOG41080R8 Conserved Protein HEP85_RS35195 ENOG4107QR9 Iron-sulfur cluster binding protein HEP85_RS35200 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HEP85_RS35205 ENOG4105DET Rhamnulokinase HEP85_RS35220 ENOG4105C2J ABC transporter HEP85_RS35230 ENOG4105F5R ABC transporter HEP85_RS35250 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS35260 ENOG4108KPJ rna polymerase sigma factor HEP85_RS35270 ENOG4105DDN Pentapeptide repeat-containing protein HEP85_RS35275 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HEP85_RS35280 ENOG4108R86 Transcriptional regulator HEP85_RS35290 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HEP85_RS35315 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HEP85_RS35370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HEP85_RS35375 ENOG4105E0A ABC, transporter HEP85_RS35385 ENOG4105DQ5 transport system permease protein HEP85_RS35390 ENOG4108MES Periplasmic binding protein HEP85_RS35395 ENOG4108URH decarboxylase HEP85_RS35410 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP85_RS35435 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HEP85_RS35490 ENOG41065SU Two-component system sensor kinase HEP85_RS35495 ENOG4108KXV response regulator HEP85_RS35515 ENOG4105CHM Aminotransferase HEP85_RS35520 ENOG4105E39 Enoyl-CoA hydratase HEP85_RS35530 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HEP85_RS35545 ENOG4105E2R ROK family HEP85_RS35555 ENOG4105DCG PHP domain protein HEP85_RS35600 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEP85_RS35620 ENOG4105ECQ AraC Family Transcriptional Regulator HEP85_RS35625 ENOG4105EQ0 Major Facilitator superfamily HEP85_RS35630 ENOG4105CPQ Dehydrogenase HEP85_RS35650 ENOG4108KPJ rna polymerase sigma factor HEP85_RS35685 ENOG4105D7V transposase HEP85_RS35700 ENOG4105CUB amino acid HEP85_RS35745 ENOG4106YKD Cytochrome p-450 HEP85_RS35775 ENOG4105F8D glycoside hydrolase family 4 HEP85_RS35785 ENOG4105DRS transport system, permease HEP85_RS35805 ENOG4105EBM Alpha Beta Hydrolase Fold protein HEP85_RS35840 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP85_RS35865 ENOG4108JQ1 Dehydrogenase HEP85_RS35870 ENOG4105DMF Dehydrogenase HEP85_RS35900 ENOG4106C4P Strong inhibitor of bacterial serine proteases such as subtilisin (By similarity) HEP85_RS35925 ENOG4108JJ7 ABC transporter HEP85_RS35930 ENOG4108JJA ABC, transporter HEP85_RS35970 ENOG4105XRQ Xanthine dehydrogenase accessory factor HEP85_RS35985 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEP85_RS35990 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP85_RS36000 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEP85_RS36050 ENOG4105EMU Dehydrogenase HEP85_RS36080 ENOG4108QDA dioxygenase HEP85_RS36085 ENOG41073TP transcriptional regulator HEP85_RS36090 ENOG4107S2Z UPF0761 membrane protein HEP85_RS36095 ENOG4105BZU Histidine kinase HEP85_RS36115 ENOG4105E2R ROK family HEP85_RS36160 ENOG4108E16 pectate lyase HEP85_RS36170 ENOG41067SE Tetr family transcriptional regulator HEP85_RS36180 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEP85_RS36205 ENOG4105CPC Aldo Keto reductase HEP85_RS36300 ENOG4107SET aldo keto reductase HEP85_RS36305 ENOG4108R5S membrane HEP85_RS36315 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HEP85_RS36335 ENOG4107TPY serine threonine protein kinase HEP85_RS36365 ENOG4108FUF Transcriptional regulator, IclR family HEP85_RS36375 ENOG4105CHR reductase HEP85_RS36385 ENOG4105CSH Transporter HEP85_RS36450 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEP85_RS36480 ENOG4105C9B Cysteine desulfurase HEP85_RS36495 ENOG4105CJ1 ABC, transporter HEP85_RS36500 ENOG4105BZU Histidine kinase HEP85_RS36505 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS36510 ENOG4105IDI abc transporter atp-binding protein HEP85_RS36520 ENOG4105C4C beta-galactosidase HEP85_RS36640 ENOG4107SVN transposase HEP85_RS36665 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEP85_RS36815 ENOG4107SVN transposase HEP85_RS36840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP85_RS36850 ENOG4107VHA regulatoR HEP85_RS36855 ENOG4107RSM transcriptional regulator HEP85_RS36865 ENOG4105CV8 reductase HEP85_RS36885 ENOG41073TP transcriptional regulator HEP85_RS36945 ENOG4105E2A Dehydrogenase HEP85_RS37000 ENOG4108KPJ rna polymerase sigma factor HEP85_RS37030 ENOG4108ZHJ Organic hydroperoxide resistance protein HEP85_RS37080 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HEP85_RS37100 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEP85_RS37170 ENOG4107SM8 Adenylate Guanylate cyclase HEP85_RS37185 ENOG4107SVN transposase HEP85_RS37210 ENOG4107EJG GntR family transcriptional regulator HEP85_RS37220 ENOG4108JYK Dehydrogenase HEP85_RS37240 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEP85_RS37280 ENOG4105CNQ glycine cleavage T protein, aminomethyl transferase HEP85_RS37290 ENOG4108R85 Short chain dehydrogenase HEP85_RS37325 ENOG4105YVS arsR family transcriptional regulator HEP85_RS37355 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HEP85_RS37410 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS37425 ENOG4107R6F Alpha Beta Hydrolase Fold protein HEP85_RS37470 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP85_RS37485 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HEP85_RS37530 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS37535 ENOG4105VEQ Cold shock protein HEP85_RS37605 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEP85_RS37610 ENOG4107QN2 dihydrolipoyl dehydrogenase HEP85_RS37630 ENOG4108YYC ycei family HEP85_RS37650 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS37655 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HEP85_RS37660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP85_RS37665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS37670 ENOG4105C3U ABC transporter HEP85_RS37680 ENOG4108HKT sucrose-6-phosphate hydrolase HEP85_RS37700 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HEP85_RS37775 ENOG4105BZU Histidine kinase HEP85_RS37880 ENOG4105EMU Dehydrogenase HEP85_RS37885 ENOG4105CPC Aldo Keto reductase HEP85_RS37890 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HEP85_RS37950 ENOG4105CD5 CoA-binding domain protein HEP85_RS37975 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEP85_RS37995 ENOG4105E2A Dehydrogenase HEP85_RS38075 ENOG4105F5W AtP-binding protein HEP85_RS38080 ENOG4106IJN integrase catalytic domain-containing protein HEP85_RS38170 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator HEP85_RS38175 ENOG4105CNN ABC, transporter HEP85_RS38180 ENOG4105C2J ABC transporter HEP85_RS38185 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS38210 ENOG41085W3 Transposase HEP85_RS38220 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HEP85_RS38330 ENOG4105DBE peroxidase HEP85_RS38340 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP85_RS38365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEP85_RS38370 ENOG4105BZU Histidine kinase HEP85_RS38680 ENOG41082YX Transcriptional regulator, arsr family HEP85_RS38690 ENOG4105H3G oxidoreductase HEP85_RS38710 ENOG4108UXE Protein tyrosine phosphatase HEP85_RS38715 ENOG4105C3M thioredoxin reductase HEP85_RS38740 ENOG4105VEQ Cold shock protein HEP85_RS38780 ENOG4105EBM Alpha Beta Hydrolase Fold protein HEP85_RS38785 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEP85_RS38795 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEP85_RS39065 ENOG4105CFQ glutamine synthetase HEP85_RS39260 ENOG4107TK4 histidinol-phosphate phosphatase HEP85_RS39280 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP85_RS39285 ENOG4105EMU Dehydrogenase HEP85_RS39415 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HEP85_RS39420 ENOG4105D9P serine threonine protein kinase HEP85_RS39425 ENOG4105D9P serine threonine protein kinase HEP85_RS39540 ENOG4105NAF rna polymerase sigma factor HEP85_RS39560 ENOG4108JGH Tetr family transcriptional regulator HEP85_RS39595 ENOG4108HMN Caspase domain HEP85_RS39600 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HEP85_RS39615 ENOG4105C0D helicase HEP85_RS39620 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein HEP85_RS39685 ENOG4105D5G Transposase HEP85_RS39700 ENOG41066UM arsR family transcriptional regulator HEP85_RS39765 ENOG410836F Transposase HEP85_RS39820 ENOG4107SM8 Adenylate Guanylate cyclase HEP85_RS39825 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS39855 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HEP85_RS39870 ENOG4105CH7 arginosuccinase HEP85_RS39890 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEP85_RS39895 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HEP85_RS39920 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HEP85_RS39995 ENOG4106NZI LysR family Transcriptional regulator HEP85_RS40125 ENOG4105CIS alcohol dehydrogenase HEP85_RS40165 ENOG4105MSB protein, conserved in bacteria HEP85_RS40190 ENOG4108RCM Nitroreductase HEP85_RS40240 ENOG4108YYQ gCN5-related N-acetyltransferase HEP85_RS40255 ENOG4105C0B DNA polymerase III (alpha subunit) HEP85_RS40380 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HEP85_RS40460 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HEP85_RS40540 ENOG4105F7P transcriptional regulator AsnC family HEP85_RS40550 ENOG4105KA0 thioesterase Superfamily protein HEP85_RS40585 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HEP85_RS40620 ENOG4105F5W AtP-binding protein HEP85_RS40655 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HEP85_RS40720 ENOG4105VBF alkaline shock protein HEP85_RS40725 ENOG4105EMN RNA polymerase sigma factor HEP85_RS40780 ENOG4108XNA Gas vesicle HEP85_RS40805 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEP85_RS40830 ENOG4105EMU Dehydrogenase HEP85_RS40840 ENOG4107UVD Beta-phosphoglucomutase family hydrolase HEP85_RS40870 ENOG41068WN HEP85_RS40875 ENOG4107QM2 Aldo Keto reductase HEP85_RS40880 ENOG4108FN7 Aldo keto reductase HEP85_RS40885 ENOG4105G2Y Transcriptional regulator HEP85_RS40890 ENOG4105ECY inositol monophosphatase HEP85_RS40960 ENOG4105CN5 Metallo-Beta-Lactamase HEP85_RS40985 ENOG4105DFW ABC transporter HEP85_RS40990 ENOG4105C2J ABC transporter HEP85_RS40995 ENOG4108HWW ABC transporter HEP85_RS41025 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HEP85_RS41085 ENOG4105DFH Transport of potassium into the cell (By similarity) HEP85_RS41125 ENOG4105E2R ROK family HEP85_RS41130 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS41170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP85_RS41180 ENOG4105E2R ROK family HEP85_RS41190 ENOG4106N3A copper homeostasis protein cutc HEP85_RS41210 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HEP85_RS41225 ENOG4107SM8 Adenylate Guanylate cyclase HEP85_RS41295 ENOG4106A3M Cytochrome p-450 HEP85_RS41330 ENOG4105CWX Alpha-1,2-mannosidase HEP85_RS41385 ENOG4108IG5 Transcriptional regulator HEP85_RS41425 ENOG4105VMP Transcriptional regulator HEP85_RS41460 ENOG4105JAB phenazine biosynthesis protein, phzf family HEP85_RS41475 ENOG4106R7G Glycoside hydrolase family 5 HEP85_RS41480 ENOG41065HY 1,4-beta-cellobiosidase HEP85_RS41500 ENOG4107TYA transient receptor potential locus HEP85_RS41505 ENOG4105CPQ Dehydrogenase HEP85_RS41510 ENOG4105WEM extracellular solute-binding protein HEP85_RS41520 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HEP85_RS41525 ENOG4105E2R ROK family HEP85_RS41580 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HEP85_RS41600 ENOG4106T9R serine protease HEP85_RS41625 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HEP85_RS41640 ENOG4105DEF Extracellular solute-binding protein, family 5 HEP85_RS41650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS41675 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HEP85_RS41680 ENOG41067RQ csbd family HEP85_RS41685 ENOG4105EBR Carboxylesterase HEP85_RS41690 ENOG4105CHR reductase HEP85_RS41730 ENOG4105DZ6 Band 7 protein HEP85_RS41840 ENOG4107SM8 Adenylate Guanylate cyclase HEP85_RS41885 ENOG4105C57 major facilitator superfamily HEP85_RS41905 ENOG4105NRA 50s ribosomal protein l31 type b HEP85_RS41920 ENOG4108QBF Transcriptional regulator HEP85_RS41930 ENOG4105JSC dimethylmenaquinone methyltransferase HEP85_RS41945 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEP85_RS41960 ENOG4105EQX glucarate dehydratase HEP85_RS41965 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HEP85_RS41970 ENOG4107HP6 Transcriptional regulator HEP85_RS41985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEP85_RS42000 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HEP85_RS42005 ENOG4105CFG Acts as a chaperone (By similarity) HEP85_RS42015 ENOG4107RTD sua5 ycio yrdc ywlc family protein HEP85_RS42040 ENOG4105EWK phytoene HEP85_RS42045 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEP85_RS42055 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HEP85_RS42060 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEP85_RS42065 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HEP85_RS42105 ENOG4105WN5 stage II sporulation protein HEP85_RS42170 ENOG4108IAJ Nad-dependent epimerase dehydratase HEP85_RS42220 ENOG4105CSR polyphosphate kinase 2 HEP85_RS42240 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HEP85_RS42260 ENOG4106A3M Cytochrome p-450 HEP85_RS42315 ENOG4108V1U phospholipid-binding protein HEP85_RS42355 ENOG4105EMU Dehydrogenase HEP85_RS42360 ENOG4105E1F short-chain dehydrogenase reductase HEP85_RS42440 ENOG4108PSK reductase HEP85_RS42480 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEP85_RS42500 ENOG4108W6C Dehydrogenase HEP85_RS42525 ENOG4108YIQ Alpha beta hydrolase HEP85_RS42550 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HEP85_RS42555 ENOG4108XHQ (2Fe-2S)-binding domain protein HEP85_RS42560 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HEP85_RS42595 ENOG4108M8W Monooxygenase HEP85_RS42630 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HEP85_RS42635 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HEP85_RS42675 ENOG41082AN stage II sporulation protein HEP85_RS42680 ENOG41082AN stage II sporulation protein HEP85_RS42700 ENOG4105BZU Histidine kinase HEP85_RS42765 ENOG4105E1F short-chain dehydrogenase reductase HEP85_RS42785 ENOG4105ETS cytosine purines uracil thiamine allantoin HEP85_RS42795 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HEP85_RS42820 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HEP85_RS42825 ENOG41090R7 Ferric uptake HEP85_RS42845 ENOG4108K8U Glycerol operon regulatory protein HEP85_RS42850 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEP85_RS42865 ENOG4105ENX hydrolase HEP85_RS42885 ENOG4107R33 ppx gppa phosphatase HEP85_RS42895 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HEP85_RS42925 ENOG4108JQ7 (ABC) transporter HEP85_RS42930 ENOG4105C3U ABC transporter HEP85_RS42935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEP85_RS42940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEP85_RS42970 ENOG4105E2A Dehydrogenase HEP85_RS42995 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS43000 ENOG4105EGE secreted protein HEP85_RS43035 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HEP85_RS43070 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEP85_RS43085 ENOG4105CSA Coproporphyrinogen iii oxidase HEP85_RS43150 ENOG4108UZX fmn reductase HEP85_RS43155 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HEP85_RS43160 ENOG4107YFT Nadph-dependent fmn reductase HEP85_RS43165 ENOG4105ME7 Membrane HEP85_RS43170 ENOG4105EZR dyp-type peroxidase family protein HEP85_RS43190 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEP85_RS43230 ENOG4105E39 Enoyl-CoA hydratase HEP85_RS43245 ENOG4107R9S Malate synthase HEP85_RS43275 ENOG4105DYW oxidoreductase HEP85_RS43295 ENOG4105WH1 Two component transcriptional regulator luxr family HEP85_RS43300 ENOG4105ENE Histidine kinase HEP85_RS43310 ENOG4105EKT )-iron permease HEP85_RS43325 ENOG4105C57 major facilitator superfamily HEP85_RS43330 ENOG4108TCS Glutamyl endopeptidase HEP85_RS43335 ENOG4107258 Transcriptional regulator HEP85_RS43350 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HEP85_RS43395 ENOG4105NPE arsR family transcriptional regulator HEP85_RS43405 ENOG4108NNZ chitinase HEP85_RS43435 ENOG4105CWX Alpha-1,2-mannosidase HEP85_RS43500 ENOG4105ETE Transcriptional regulator (LacI family HEP85_RS43505 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEP85_RS43510 ENOG4105C2J ABC transporter HEP85_RS43515 ENOG4105CNN ABC, transporter HEP85_RS43520 ENOG4105CNN ABC, transporter HEP85_RS43580 ENOG4105C28 cystathionine HEP85_RS43585 ENOG4105EW9 transcriptional regulator AsnC family HEP85_RS43590 ENOG4105JAB phenazine biosynthesis protein, phzf family HEP85_RS43600 ENOG4107RA9 decarboxylase HEP85_RS43630 ENOG4107U9T Pfam:Ribonuclease_BN HEP85_RS43640 ENOG4105BZU Histidine kinase HEP85_RS43650 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HEP85_RS43655 ENOG4105CIR epoxide hydrolase